An assessment of neck node immunoreactivity in head and neck cancer.
Current conventional forms of cancer treatment represent non-specific modalities that destroy not only cancerous but also non-cancerous tissue in an effort to totally eradicate the neoplasm. It was unknown in head and neck cancer whether a more specific form of treatment, as it relates to neck nodal disease, was advisable. The purpose of this investigation was to study the cervical node immunoreactivity in head and neck cancer patients as a means of determining their immunologic capabilities and thus provide information about the merits of specific vs. non-specific cancer treatment. The results demonstrated that lymphocytes arising from cervical nodes caused alterations in the tumor growth. There appeared to be no particular difference in immunoreactivity of lymphocytes arising from nodes located in different areas of the neck. The regional immune system of neck nodes in the head and neck cancer patient appears to be capable of mounting an immune response irrespective of the patient's tumor status. Usual measures of systemic immunocompetence failed to identify any patients with advanced stage disease and showed little correlation with the regional immunoreactivity. The regional nodal immunoreactivity also did not correlate with the size or the numbers of metastatic neck nodes. The results demonstrate that cervical neck nodes are capable of mounting an immune response to head and neck cancer and are not mere passive filters that are periodically involved with tumor emboli. These results support the need for the development of reliable treatments which are directed at tumor tissue only.
D000818:Animals; D006258:Head and Neck Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D006801:Humans; D007121:Immunocompetence / Q000187:drug effects / Q000528:radiation effects; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000276:immunology*; D008207:Lymphatic Metastasis; D008208:Lymphatic System / Q000033:anatomy & histology / Q000276:immunology / Q000473:pathology; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology; D051379:Mice; D008819:Mice, Nude; D009333:Neck / Q000033:anatomy & histology; D011379:Prognosis; D011446:Prospective Studies; D014410:Tumor Stem Cell Assay