REM sleep deprivation decreases the antinociceptive property of enkephalinase-inhibition, morphine and cold-water-swim.
Rats treated with phosphoramidon (an enkephalinase-inhibitor 250 micrograms, i.c.v.), morphine (20 micrograms i.c.v.) or subjected to cold-water-swim (CWS, animals forced to swim in water at 5 degrees C for 5 min) showed consistent analgesia. The antinociceptive effect of phosphoramidon, morphine and CWS was antagonised by REM sleep deprivation (REMSD). It is suggested that normal duration of REM sleep is of importance for the anti-nociceptive activity of endogenous and exogenous opiates.
D000698:Analgesia; D000818:Animals; D003080:Cold Temperature; D006020:Glycopeptides / Q000494:pharmacology; D008297:Male; D009020:Morphine; D015260:Neprilysin; D011480:Protease Inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D012892:Sleep Deprivation / Q000502:physiology*; D012895:Sleep, REM; D013550:Swimming
D006020:Glycopeptides; D011480:Protease Inhibitors; D009020:Morphine; D015260:Neprilysin; C008890:phosphoramidon