Does casomorphin have a functional role?
Degradation of buffalo beta-casein by various physiological enzymes was studied. Digestion with gastric and pancreatic proteases plus leucine aminopeptidase did not release casomorphins but a putative precursor (procasomorphin) which was further digested by brush border peptidases into peptides differing from casomorphins.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002364:Caseins / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004723:Endorphins / Q000378:metabolism*; D005750:Gastric Juice / Q000201:enzymology; D007931:Leucyl Aminopeptidase / Q000378:metabolism; D008871:Microvilli / Q000201:enzymology; D010189:Pancreatic Juice / Q000201:enzymology; D010446:Peptide Fragments; D010447:Peptide Hydrolases / Q000378:metabolism; D011498:Protein Precursors / Q000378:metabolism; D011817:Rabbits
D000596:Amino Acids; D002364:Caseins; D004723:Endorphins; D010446:Peptide Fragments; D011498:Protein Precursors; C041128:beta-casomorphin 7; D010447:Peptide Hydrolases; D007931:Leucyl Aminopeptidase