Ability of indomethacin to alter prostaglandin metabolite concentrations and to enhance the function of corpora lutea induced in postpartum suckled beef cows.
Fourteen anovulatory postpartum (38.0 +/- 1.9 d) beef cows that ovulated after an injection of 250 micrograms gonadotropin releasing hormone (GnRH) in saline were used to examine the influence of indomethacin on luteal function. Beginning the d after GnRH, 6 cows were given intrauterine infusions of indomethacin for 14 d and the other eight cows received vehicle. After GnRH treatment, concentrations of progesterone in serum were elevated longer (P less than .01) for indometacin-treated cows than for vehicle-treated cows. At the same time prostaglandin metabolite (PGFM) concentrations were lower (P less than .01) in indomethacin-treated cows than in vehicle-treated cows. In summary, indomethacin suppressed PGFM concentrations and enhanced function of corpora lutea induced in postpartum suckled beef cows.
D000818:Animals; D002417:Cattle / Q000502:physiology*; D003338:Corpus Luteum / Q000187:drug effects* / Q000502:physiology; D015237:Dinoprost / Q000031:analogs & derivatives*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D007774:Lactation; D010062:Ovulation Induction; D010906:Pituitary Hormone-Releasing Hormones / Q000494:pharmacology; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011460:Prostaglandins F / Q000097:blood*
D010906:Pituitary Hormone-Releasing Hormones; D011460:Prostaglandins F; C026527:13,14-dihydroprostaglandin F2alpha; D011374:Progesterone; D015237:Dinoprost; D007213:Indomethacin