Metabolism of stilbene estrogens and steroidal estrogens in relation to carcinogenicity.
The oxidative metabolism of diethylstilbestrol (DES) and 17 alpha-ethynyl estradiol, as examples of stilbene- and steroid-type estrogens, is discussed with respect to the formation of reactive intermediates. For DES, a genotoxic potential is implied by metabolic studies and positive effects in short-term tests for genetic damage. A particularly important pathway for DES carcinogenicity appears to be peroxidase-mediated oxidation. Although data for steroidal estrogens are more ambiguous, the available evidence suggests that metabolic activation by peroxidatic oxidation may also be of importance for this class of estrogens.
D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000378:metabolism*; D006224:Cricetinae; D004054:Diethylstilbestrol / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D004967:Estrogens / Q000378:metabolism* / Q000633:toxicity; D004997:Ethinyl Estradiol / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D008297:Male; D008647:Mesocricetus; D009369:Neoplasms / Q000139:chemically induced*; D010084:Oxidation-Reduction
D002273:Carcinogens; D004967:Estrogens; D004997:Ethinyl Estradiol; D004054:Diethylstilbestrol