Comparison of acute and subacute effects of deflazacort and prednisone on glucose metabolism in man.
Corticosteroid treatment produces glucose intolerance with insulin resistance. Recent reports have indicated that deflazacort (DF) is significantly less diabetogenic than prednisone (PN). A euglycaemic hyperinsulinaemic (100 microU/ml) glucose clamp ( EHGC ) and 3H-glucose infusion for 240 min were performed in 6 healthy volunteers (HV) after administration of 15 mg PN or 18 mg DF, 12 h and 2 h before test. The glucose metabolic clearance rate (MCR) was significantly (p = 0.02) higher after DF (4.75 +/- 0.58 ml/min X kg) than after PN (3.31 +/- 0.27 ml/min X kg). Basal hepatic glucose production (HGP) was significantly (p = 0.003) lower after DF (3.58 +/- 0.33 mg/kg X min) than after PN (4.44 +/- 0.23 mg/kg X min). A similar pattern was obtained for glucose volume (GV) and glucose pool (GP). The kinetic parameters of insulin were not significantly different after the two drugs. After 7 day of PN 30 mg/day or DF 36 mg/day, EHGC and 3H-glucose infusion for 240 min were performed in 10 HV. Glucose MCR values were significantly (p = 0.03) higher after DF (5.03 +/- 0.91 ml/min X kg) than after PN (2.80 +/- 0.26 ml/min X kg). HGP values did not different significantly after the two drugs. GV (p = 0.001) and GP (p = 0.002) were significantly lower after DF than after PN. Insulin kinetics were not significantly different after the two drugs. It is concluded that on acute and 7-day administration to healthy subjects DF, in an anti-inflammatory dose equivalent to PN, shows significantly less influence on glucose metabolism.
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D004334:Drug Administration Schedule; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000097:blood; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D011241:Prednisone / Q000008:administration & dosage / Q000494:pharmacology*; D011282:Pregnenediones / Q000008:administration & dosage / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D001786:Blood Glucose; D007328:Insulin; D011282:Pregnenediones; D005947:Glucose; C021988:deflazacort; D011241:Prednisone