Human mammary and bronchial carcinomas. In vivo and in vitro secretion of substances immunologically cross-reactive with insulin.
In the blood of two patients suffering from mammary carcinoma and one from bronchial carcinoma, the levels of substances immunologically cross-reactive with insulin (SICRI) were high before surgery; after surgery normoinsulinemia was restored. Direct evidence of SICRI production by the cultured tumorous tissue is presented. Strong daily SICRI fluctuations were observed, and it is proposed that the fluctuations induce instantaneous hypoglycemias experienced by some tumorous patients.
D001786:Blood Glucose / Q000032:analysis; D001943:Breast Neoplasms / Q000378:metabolism* / Q000601:surgery; D001984:Bronchial Neoplasms / Q000378:metabolism* / Q000601:surgery; D002478:Cells, Cultured; D003429:Cross Reactions; D005260:Female; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000097:blood*; D008875:Middle Aged; D011863:Radioimmunoassay; D013997:Time Factors; D014044:Tolbutamide / Q000494:pharmacology
D001786:Blood Glucose; D007328:Insulin; D014044:Tolbutamide