A possible role of intestinal mucin in the pathophysiology of intestinal strangulation obstruction. Consequences of tracing a clinical observation.
In intestinal strangulation obstruction, the pathophysiology is created by factors deriving from the host as well as from the intestinal flora. This article has focused upon the importance of one host-derived factor, i.e. intestinal mucin. Based upon a long series of in vitro and in vivo experiments utilizing germfree as well as conventional animals, it is concluded that intestinal mucin plays a major role in triggering a pathological plasma proteolysis, thereby interacting with microbial products (as endotoxin) in creating the whole variety of serious symptoms found in this situation.
D000818:Animals; D001798:Blood Proteins / Q000502:physiology; D004195:Disease Models, Animal; D004731:Endotoxins / Q000378:metabolism; D004926:Escherichia coli / Q000472:pathogenicity; D005856:Germ-Free Life; D006023:Glycoproteins / Q000502:physiology; D007082:Ileum / Q000503:physiopathology; D007413:Intestinal Mucosa / Q000382:microbiology; D007415:Intestinal Obstruction / Q000503:physiopathology*; D007419:Intestinal Secretions / Q000502:physiology*; D051379:Mice; D009077:Mucins / Q000502:physiology*; D010587:Phagocytosis; D051381:Rats; D014774:Virulence
D001798:Blood Proteins; D004731:Endotoxins; D006023:Glycoproteins; D009077:Mucins