title: Amino acid sequence of human factor D of the complement system. Similarity in sequence between factor D and proteases of non-plasma origin.
abstract: The amino acid sequence of human factor D is proposed from the analysis of the peptides produced by treatment of the factor D with cyanogen bromide, iodosobenzoic acid, trypsin and V-8 protease. Comparison of the proposed sequence with the sequences of other serine esterases indicated that factor D, although it is a plasma serine esterase, is more closely related to certain proteases not found in the plasma than to other plasma serine esterases of the complement system. For example, 36% and 32% identity in amino acid sequence was found on comparison of factor D with elastase and group-specific protease, respectively. Whereas only 27% and 18% identity was observed between factor D and the other complement serine esterases, Clr and factor B, respectively.
mesh_terms: D000595:Amino Acid Sequence; D002268:Carboxypeptidases; D003166:Complement Activating Enzymes / Q000302:isolation & purification*; D011416:Complement Factor D / Q000302:isolation & purification*; D003488:Cyanogen Bromide; D010450:Endopeptidases; D006801:Humans; D010446:Peptide Fragments; D010447:Peptide Hydrolases; D012697:Serine Endopeptidases; D014357:Trypsin
chemical_list: D010446:Peptide Fragments; D003166:Complement Activating Enzymes; D002268:Carboxypeptidases; D010450:Endopeptidases; D010447:Peptide Hydrolases; C022633:serine carboxypeptidase; D012697:Serine Endopeptidases; C028344:glutamyl endopeptidase; D014357:Trypsin; C493488:CFD protein, human; D011416:Complement Factor D; D003488:Cyanogen Bromide