Shiga-like toxin-converting phages from Escherichia coli strains that cause hemorrhagic colitis or infantile diarrhea.
Escherichia coli K-12 acquired the ability to produce a high titer of Shiga-like toxin after lysogenization by either of two different bacteriophages isolated from a highly toxinogenic Escherichia coli O157:H7 strain that causes hemorrhagic colitis. One of these phages and another Shiga-like toxin-converting phage from an Escherichia coli O26 isolate associated with infantile diarrhea were closely related in terms of morphology, virion polypeptides, DNA restriction fragments, lysogenic immunity, and heat stability, although a difference in host range was noted. These phages are currently the best-characterized representatives from a broader family of Shiga-like toxin-converting phages.
D000818:Animals; D001427:Bacterial Toxins / Q000378:metabolism*; D001435:Bacteriophages / Q000378:metabolism*; D003093:Colitis, Ulcerative / Q000382:microbiology*; D004279:DNA, Viral / Q000378:metabolism; D003968:Diarrhea, Infantile / Q000382:microbiology*; D004926:Escherichia coli / Q000378:metabolism*; D006801:Humans; D011817:Rabbits; D022603:Shiga Toxins
D001427:Bacterial Toxins; D004279:DNA, Viral; D022603:Shiga Toxins