Captopril-induced deterioration of graft function in patients with a transplant renal artery stenosis.
We evaluated nine captopril-treated patients with transplant renal artery stenosis. Captopril treatment always resulted in a dramatic decrease in renal function; in two patients complete anuria developed. Only in two patients with a stenosis in one out of two renal arteries was a satisfactory fall in blood pressure achieved. The mechanisms which may lead to these remarkable results will be discussed.
D058186:Acute Kidney Injury / Q000209:etiology; D000293:Adolescent; D000328:Adult; D002216:Captopril / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011392:Proline / Q000031:analogs & derivatives*; D012078:Renal Artery Obstruction / Q000188:drug therapy*
D011392:Proline; D002216:Captopril