Treating gonococcal urethritis in men: oral amoxycillin potentiated by clavulanate compared with intramuscular procaine penicillin.
In a study of 121 men with uncomplicated gonococcal urethritis, 64 were treated orally with a single dose of 3 g amoxycillin and 250 mg of the specific beta-lactamase inhibitor, clavulanic acid, and 57 with a single intramuscular injection of 2.4 MU procaine penicillin. After seven days, six (9.4%) patients treated with amoxycillin and clavulanic acid were still culture positive for Neisseria gonorrhoeae, compared with 26.3% of those treated with procaine penicillin.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000658:Amoxicillin / Q000008:administration & dosage* / Q000627:therapeutic use; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004357:Drug Synergism; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D010402:Penicillin G Procaine / Q000008:administration & dosage* / Q000627:therapeutic use; D014526:Urethritis / Q000188:drug therapy*
D002969:Clavulanic Acids; D004338:Drug Combinations; D010402:Penicillin G Procaine; D019818:Clavulanic Acid; D000658:Amoxicillin