title: The role of DNA repair processes in the response of human tumors to fractionated radiotherapy.
abstract: The relationship of inherent radiosensitivity, sublethal and potentially lethal damage repair to radiation therapy is not yet fully explained. I will examine how these various repair processes might be relevant to radiotherapy, based on laboratory investigation of human tumor cells in vitro. Although radiocurability is a complex function, recovery processes manifested in the post-radiation period may be a determinant of radiocurability.
mesh_terms: D001260:Ataxia Telangiectasia / Q000473:pathology; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D004247:DNA / Q000528:radiation effects; D004260:DNA Repair; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000528:radiation effects; D006801:Humans; D008545:Melanoma / Q000473:pathology; D009062:Mouth Neoplasms / Q000473:pathology; D009369:Neoplasms / Q000532:radiotherapy*; D011836:Radiation Tolerance; D014983:Xeroderma Pigmentosum / Q000473:pathology
chemical_list: D004247:DNA