Presence of "rheumatoid neoantigen-like material" in urine of patients with RA, demonstrated by use of leukocyte adherence inhibition assay.
Peripheral blood leukocytes (PBL) from patients with rheumatoid arthritis (RA) when used in the leukocyte adherence inhibition (LAI) assay were capable of distinguishing antigenic differences between rheumatoid and osteoarthritic synovial membrane extracts. The positive LAI response of RA patients was negated by preincubating the cells with sera or urine proteins obtained from LAI nonreactive RA patients. This study suggests that LAI nonreactive RA subjects have in their serum a material cross reactive with rheumatoid synovium which we have called "rheumatoid neoantigen-like material" which is excreted in their urine, and is capable of being recognized by PBL of reactive, LAI positive RA patients.
D000941:Antigens / Q000652:urine*; D016918:Arthritis, Reactive / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001324:Autoantigens / Q000652:urine*; D006073:Gout / Q000276:immunology; D006801:Humans; D007158:Immunologic Techniques; D007957:Leukocyte Adherence Inhibition Test; D007962:Leukocytes / Q000276:immunology; D010003:Osteoarthritis / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000276:immunology; D013582:Synovial Fluid / Q000276:immunology; D013583:Synovial Membrane / Q000276:immunology
D000941:Antigens; D001324:Autoantigens