Long-term study of cloprednol in asthmatic patients.
Cloprednol was used in 18 steroid-dependent patients with chronic reversible bronchial obstruction over a period of 2 years with respect to HPA-axis function and effect on their clinical status. Patients were treated with a single morning dose of 5-12.5 mg orally. 16 patients were maintained clinically satisfactorily with little change in their steroid status. It was concluded that cloprednol was a satisfactory oral steroid in this group of patients when given as a one-daily morning dose.
D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000311:Adrenal Glands / Q000502:physiology; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D011282:Pregnenediones / Q000627:therapeutic use*; D012129:Respiratory Function Tests; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D011282:Pregnenediones; C011731:cloprednol; D006854:Hydrocortisone