Dopamine and depression: a review of recent evidence. II. Theoretical approaches.
This paper discusses 3 behavioural approaches to depression, 'learned helplessness', reward system dysfunction and reduced responsiveness to the environment, and the role of dopamine (DA) in their related animal models. The meso-limbic and nigrostriatal DA system appears to be related primarily to responsiveness to the environment. This conclusion is discussed in relation to the clinical symptomatology of depression.
D000818:Animals; D001143:Arousal / Q000502:physiology; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000378:metabolism; D003866:Depressive Disorder / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006380:Helplessness, Learned / Q000523:psychology; D006801:Humans; D009434:Neural Pathways / Q000378:metabolism; D011954:Receptors, Dopamine / Q000378:metabolism*; D012106:Research; D012201:Reward; D012931:Social Environment
D011954:Receptors, Dopamine; D004298:Dopamine