Osteogenic sarcoma producing human chorionic gonadotrophin. Case report with immunohistochemical studies.
An osteogenic sarcoma occurring in a 22-year-old woman was found to be associated with production of a large amount of beta human chorionic gonadotrophin (B-hCG). Pregnancy was excluded on the basis of a normal ultrasonogram and a proliferative type endometrium obtained by curettage. A homogenate of the tumor was strongly positive for B-hCG while immunohistochemical staining of the tumor cells was strongly positive for B-hCG and negative for pregnancy associated glycoprotein. These results indicate ectopic production of hCG by the osteosarcoma.
D000328:Adult; D006063:Chorionic Gonadotropin / Q000032:analysis / Q000378:metabolism*; D005260:Female; D005266:Femoral Neoplasms / Q000378:metabolism* / Q000473:pathology; D006729:Hormones, Ectopic / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D012516:Osteosarcoma / Q000378:metabolism* / Q000473:pathology
D006063:Chorionic Gonadotropin; D006729:Hormones, Ectopic