Rat liver regeneration after 90% partial hepatectomy.
In previous studies, 90% partial hepatectomy in the rat was invariably accompanied by 100% mortality within 40 hr. This paper describes a technique by which 90% of the liver mass can be removed with only 14% mortality, provided that rats have free access to glucose-containing drinking water. Measurements of total liver DNA, [3H]thymidine labeling index and mitotic index suggest rapid cell proliferation, commensurate with a powerful regenerative stimulus. In the presence of normoglycemia, peripheral insulin and glucagon concentrations were elevated to levels normally observed in the portal vein.
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D005260:Female; D005934:Glucagon / Q000378:metabolism; D005947:Glucose / Q000008:administration & dosage; D006498:Hepatectomy; D007328:Insulin / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008115:Liver Regeneration; D008940:Mitotic Index; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D007328:Insulin; D004247:DNA; D005934:Glucagon; D005947:Glucose