A comparison of sustained-release terbutaline with ordinary salbutamol in bronchial asthma.
The effects of a sustained-release preparation of terbutaline, depot tablets, 7.5 mg 2 times/day were compared with ordinary salbutamol tablets 4 mg 3 times/day. The study, performed for 2 weeks, one week on each treatment, was double-blind, double-dummy, crossover with randomized allocation of the drugs. Twenty-five patients with chronic bronchial asthma completed the trial. The morning Peak-Flow was higher during the period on the depot tablets compared to that on the ordinary tablets (p less than 0.05). No differences were found in side effects.
D000328:Adult; D000368:Aged; D000420:Albuterol / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate; D011897:Random Allocation; D013726:Terbutaline / Q000008:administration & dosage / Q000627:therapeutic use*
D003692:Delayed-Action Preparations; D013726:Terbutaline; D000420:Albuterol