title: Early diagnosis of rejection. Correlation of enzymuria and histological findings after renal transplantation in the rat.
abstract: One hundred renal transplants were performed between different rat strain combinations. Posttransplant renal function was monitored using serum creatinine levels, creatinine clearance rates, and N-acetyl-beta-D-glucosaminidase (NAG) enzymuria. These biochemical measurements were compared with the morphological appearances of the transplanted kidney. Rises in NAG enzymuria proved to be useful diagnostic indicators of graft rejection with a false positive rate of only 6%. In 78% of the rejection episodes, the urinary NAG level rose 2 days before any elevation in serum creatinine concentration. There was a close correlation among increasing NAG enzymuria, decreasing renal function, and the structural events of rejection--indicating that the routine measurement of tubular enzymuria would be of value in the prediction and diagnosis of renal allograft rejection.
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine*; D000818:Animals; D003404:Creatinine / Q000097:blood; D005260:Female; D006084:Graft Rejection; D006596:Hexosaminidases / Q000652:urine*; D007668:Kidney / Q000276:immunology / Q000473:pathology; D016030:Kidney Transplantation; D008297:Male; D011183:Postoperative Complications / Q000175:diagnosis / Q000201:enzymology / Q000473:pathology; D051381:Rats; D011917:Rats, Inbred Lew; D013997:Time Factors
chemical_list: D003404:Creatinine; D006596:Hexosaminidases; D000118:Acetylglucosaminidase