The distribution of dermal tumorigens in coal liquids: relationship of tumorigenicity and microbial mutagenicity.
Polycyclic aromatic hydrocarbons and/or their pyrolle derivatives were found to be the primary contributors to the skin tumorigenicity of the neutral fractions of two coal oils. Mutagenicity of the neutral fraction in Salmonella test strains was found to be due primarily to polycyclic aromatics containing polar substituents. Thus, the chemical classes responsible for skin tumorigenicity differ from those responsible for mutagenicity.
D000818:Animals; D003031:Coal / Q000032:analysis*; D005648:Fuel Oils / Q000032:analysis / Q000633:toxicity*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009152:Mutagenicity Tests; D009153:Mutagens; D010578:Petroleum / Q000633:toxicity*; D011083:Polycyclic Compounds / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000235:genetics; D012878:Skin Neoplasms / Q000139:chemically induced*
D003031:Coal; D005648:Fuel Oils; D009153:Mutagens; D010578:Petroleum; D011083:Polycyclic Compounds