title: [Fatty tissue insulin receptors in patients with an elevated level of contrainsulin hormones with and without concomitant diabetes mellitus].
abstract: An equally lowered insulin specific binding in the fatty cell plasmic membranes was found in patients with glucocorticoid, somatotropin and catecholamine hyperproduction during diabetes mellitus and/or its absence. This fall is due exclusively to a reduced amount of binding sites in patients with hypercorticism and acromegaly, accompanied or not by diabetes, and in persons with diabetes-aggravated pheochromocytoma. The above decrease is caused by a lowered binding site number and augmented negative cooperativity in patients suffering from pheochromocytoma without diabetes. The results obtained allow a conclusion that inhibited expression of insulin receptors in the presence of counter-insulin hormone hyperproduction promotes diabetes arising.
mesh_terms: D000172:Acromegaly / Q000378:metabolism; D000273:Adipose Tissue / Q000378:metabolism*; D000310:Adrenal Gland Neoplasms / Q000378:metabolism; D000308:Adrenocortical Hyperfunction / Q000378:metabolism; D000328:Adult; D002395:Catecholamines / Q000378:metabolism; D003920:Diabetes Mellitus / Q000378:metabolism*; D005260:Female; D005938:Glucocorticoids / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D007329:Insulin Antagonists / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000378:metabolism; D011485:Protein Binding; D011972:Receptor, Insulin / Q000378:metabolism*
chemical_list: D002395:Catecholamines; D005938:Glucocorticoids; D007328:Insulin; D007329:Insulin Antagonists; D013006:Growth Hormone; D011972:Receptor, Insulin
vernacular_title: Sostoianie insulinovykh retseptorov zhirovoĭ tkani u bol'nykh s povyshennym urovnem kontrinsulinovykh gormonov s soputstvuiushchim sakharnym diabetom i bez nego.