Effects of renal substitutive programs on amino acid patterns in chronic uremia.
Abnormalities in the amino acid patterns are a constant finding in chronic renal failure and can be regarded as one of the typical biochemical alterations of uremia. This paper evaluates the long-term effects of various artificial substitutive treatments and renal transplantation on plasma and tissue amino acid patterns in chronically uremic patients. Fifty-three patients were included in the study: 35 on artificial treatments (9 on hemodialysis, 9 on hemofiltration, 4 on hemoperfusion, 6 on continuous ambulatory peritoneal dialysis, and 7 on intermittent peritoneal dialysis) and 18 with well-functioning renal transplants. Complete plasma aminograms were performed in all patients before starting the treatment, and repeated every 3 months up to 1 year (artificial therapies) and 3 years (renal transplantation). The amino acid composition of the bone was also determined in 8 dialysis patients and 9 transplant patients. None of the artificial therapies was associated with normal plasma patterns either in the short- or in the long-term, whereas successful renal transplantation led to normalization of the plasma profile within 2 to 4 months in all patients. However, bone amino acid composition remained altered both in artificially treated and in transplanted patients.
D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000097:blood / Q000378:metabolism*; D001769:Blood; D001842:Bone and Bones / Q000378:metabolism*; D002606:Charcoal / Q000627:therapeutic use; D002908:Chronic Disease; D003131:Combined Modality Therapy; D004044:Dietary Proteins / Q000008:administration & dosage; D005260:Female; D006464:Hemoperfusion / Q000379:methods; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis / Q000379:methods; D013997:Time Factors; D014462:Ultrafiltration / Q000379:methods; D014511:Uremia / Q000628:therapy*
D000596:Amino Acids; D004044:Dietary Proteins; D002606:Charcoal