Renal and pancreatic transplantation in the treatment of diabetic renal failure.
Twenty-two diabetic patients with renal failure have entered an integrated dialysis and transplant programme in 30 months. Ten have subsequently undergone combined renal and segmental pancreatic transplantation, and have been followed for between one month and 25 months. Currently 80 per cent of the kidneys and 40 per cent of the pancreatic grafts are functioning. Four of the 22 patients have died from myocardial disease. Pancreatic transplantation at the time of renal grafting in diabetics does not significantly increase morbidity, and currently offers a 40 per cent chance of freedom from exogenous insulin. The successful treatment of diabetic renal failure is not compromised by the addition of this developmental procedure.
D000293:Adolescent; D000328:Adult; D003524:Cyclosporins / Q000627:therapeutic use; D003928:Diabetic Nephropathies / Q000628:therapy*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D016035:Pancreas Transplantation; D010531:Peritoneal Dialysis, Continuous Ambulatory
D003524:Cyclosporins