title: [The islands of Langerhans in rats (Rattus norvegicus, Forma alba) following administration of prednisolone - semi-quantitative light and electron microscopy study].
abstract: Light microscopic-histological and ultrastructural alterations of rat pancreatic islands and their A- and B-cells were studied after daily injections of prednisolone suspension in a high dosage. After 7 respectively 14 d we noted light microscopically an enlargement of islands, caused by an island cell hypertrophy and hyperplasia. Electron microscopically we found a remarkable degranulation and vacuolization of islands B-cells and a significant enlargement of A-cell granules. The observed alterations were discussed in respect to the prednisolone stress.
mesh_terms: D000818:Animals; D007515:Islets of Langerhans / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D011239:Prednisolone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains / Q000033:anatomy & histology*
chemical_list: D011239:Prednisolone
vernacular_title: Die Langerhansschen Inseln der Ratte (Rattus norvegicus, Forma alba) nach hohen Prednisolongaben--Eine semiquantitative licht- und elektronenmikroskopische Untersuchung.