Does secretin control insulin secretion?
The effect of secretin on insulin release has been studied in normal subjects after prestimulation with arginine. In order to make a comparison a pulse of glucose with arginine prestimulation was given. A pulse of 1 U/kg b.w. of secretin provokes a secretion of insulin that is weak and brief compared to that provoked by glucose; thus secretin fails to potentiate arginine-induced insulin secretion. Such a result does not support the hypothesis of secretin as the central hormone in the enteroinsular axis.
D000328:Adult; D001120:Arginine / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D011863:Radioimmunoassay; D012633:Secretin / Q000502:physiology*; D013997:Time Factors
D007328:Insulin; D012633:Secretin; D001120:Arginine; D005947:Glucose