title: [Mutagenic and DNA-damaging effect of potassium bichromate in Escherichia coli cells].
abstract: Mutagenic effects and DNA degradation in Escherichia coli cells treated with potassium bichromate were studied in this work. It is estimated that events taking place in cells treated with the mutagen are controlled by recB recC and sbcB gene products. The method for sedimentation analysis has revealed DNA degradation. The use of the impulse label of 3H-thymidine made it possible to detect DNA breaks in the daughter strands. This effect of potassium bichromate on DNA degradation is, possibly, connected with mutagenic repair.
mesh_terms: D002840:Chromates / Q000633:toxicity*; D004260:DNA Repair / Q000187:drug effects*; D004269:DNA, Bacterial / Q000032:analysis / Q000235:genetics*; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000235:genetics*; D005798:Genes, Bacterial / Q000187:drug effects; D009153:Mutagens; D009154:Mutation; D009691:Nucleic Acid Denaturation / Q000187:drug effects; D011192:Potassium Dichromate / Q000633:toxicity*; D012293:Rifampin / Q000494:pharmacology
chemical_list: D002840:Chromates; D004269:DNA, Bacterial; D009153:Mutagens; D011192:Potassium Dichromate; D012293:Rifampin
vernacular_title: Mutagennoe i DNK-povrezhdaiushchee deĭstvie bikhromata kaliia v kletkakh Escherichia coli.