T-cell subsets analyzed by monoclonal antibodies in patients with primary immunodeficiency diseases.
The proportion of T-cell subsets was normal in all patients with X-linked agammaglobulinemia except for an 8-month patient who showed a decrease in OKT8+ T-cell population. In two patients with hypogammaglobulinemia with IgM production, T-cell subsets were normal in distribution and the patients' B cells produced only IgM in culture with autologous T cells. A patient with common variable immunodeficiency showed no imbalance in distribution of T-cell subsets. Imbalance of regulatory T-cell subsets was found in a patient with DiGeorge syndrome and severe combined immunodeficiency.
D000293:Adolescent; D000361:Agammaglobulinemia / Q000235:genetics / Q000276:immunology; D000911:Antibodies, Monoclonal / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004062:DiGeorge Syndrome / Q000276:immunology; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007075:Immunoglobulin M / Q000096:biosynthesis; D007136:Immunoglobulins / Q000096:biosynthesis*; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D007223:Infant; D007958:Leukocyte Count; D008297:Male; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*; D014960:X Chromosome
D000911:Antibodies, Monoclonal; D007075:Immunoglobulin M; D007136:Immunoglobulins