Counter inhibitor: a low molecular weight cytokine derived from human leukocyte dialysates reverses antigen dependent PMN and macrophage migration inhibition.
A low molecular weight component, termed counter inhibitor (CI), has been partially purified from human dialyzable leukocyte extracts. Addition of CI to either a direct leukocyte or macrophage migration inhibition system results in reversal of antigen-induced migration inhibition. CI activity requires the presence of antigen for expression, but does not require that the donor of the CI be immune to the antigen used in the migration inhibition assay. Reversal of migration inhibition by CI appears to be a consequence of its ability to prevent PMNs or macrophages from responding to lymphokines which induce migration inhibition.
D000941:Antigens / Q000276:immunology; D001688:Biological Products / Q000494:pharmacology*; D002464:Cell Migration Inhibition; D016207:Cytokines; D006801:Humans; D007700:Kinetics; D007961:Leukocyte Migration-Inhibitory Factors / Q000037:antagonists & inhibitors; D008263:Macrophage Migration-Inhibitory Factors / Q000037:antagonists & inhibitors; D008264:Macrophages / Q000276:immunology; D008970:Molecular Weight; D009504:Neutrophils / Q000276:immunology; D013299:Streptodornase and Streptokinase / Q000276:immunology; D014165:Transfer Factor / Q000276:immunology* / Q000502:physiology; D014373:Tuberculin / Q000276:immunology
D000941:Antigens; D001688:Biological Products; D016207:Cytokines; D007961:Leukocyte Migration-Inhibitory Factors; D008263:Macrophage Migration-Inhibitory Factors; D014165:Transfer Factor; D014373:Tuberculin; D013299:Streptodornase and Streptokinase