[Effect of fractionation on the immunosuppressive effect of total lymphatic irradiation (TLI)].
The influence of single dose and fractionation on the immunosuppressive effect of a total lymphoid irradiation (TLI) was investigated by experimentation on animals and compared to literature. Lewis rats were irradiated with a constant temporal dose distribution. The weekly dose of 7,0 Gy was fractionated into 1 X 7,0 Gy, 2 X 3,5 Gy and 7 X 1,0 Gy, with rising total doses. The survival time of cutaneous allografts served as parameter for the immunosuppression; the toxicity of the treatment was related to the immunosuppressive effect. Immunosuppression as well as toxicity showed differences depending on fractionation. For both criteria, the fractionation of 2 X 3,5 Gy per week had better results. The validity of the Ellis formula for the immunosuppression induced by total lymphoid irradiation was restricted.
D000818:Animals; D001835:Body Weight; D006085:Graft Survival; D007108:Immune Tolerance / Q000528:radiation effects; D008208:Lymphatic System / Q000528:radiation effects*; D011878:Radiotherapy / Q000379:methods*; D051381:Rats; D011917:Rats, Inbred Lew; D016038:Skin Transplantation
Einfluss der Fraktionierung auf den immunsuppressiven Effekt einer total lymphatischen Bestrahlung (TLI).