title: Immune function in patients with ovarian carcinoma treated with irradiation or with cytostatics.
abstract: The immunocompetence of 25 patients with ovarian cancer was followed up during and after radiation or chemotherapy, by using the number of lymphocytes, E-rosette-forming cells, and mitogen responses as parameters. In comparison with chemotherapy, the irradiation caused a profound and permanent immunosuppression. In patients treated with chemotherapy, the number of E-rosette-forming cells and the mitogen responses were fewer in the patients who developed recurrence or dissemination.
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation / Q000187:drug effects / Q000528:radiation effects; D008875:Middle Aged; D008934:Mitogens / Q000494:pharmacology; D009364:Neoplasm Recurrence, Local; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000532:radiotherapy; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D008934:Mitogens