Aquilide A, a new mutagenic compound isolated from bracken fern (Pteridium aquilinum (L.) Kuhn).
A mutagenic compound, designated aquilide A, was isolated and identified from bracken fern (Pteridium aquilinum (L.) Kuhn). Aquilide A was found to be responsible for greater than 50% of the mutagenic activity observed after incubation of the methanol extract at alkaline conditions. This compound was found to be a potent genotoxic compound in mammalian cells in vitro and therefore, may be responsible for at least part of the carcinogenic activity of bracken. The instability of aquilide A under conditions normally encountered during analytical chemical procedures may explain why so many efforts to elucidate the carcinogenic factor(s) present in bracken have been unsuccessful.
D000818:Animals; D001711:Biotransformation; D007189:Indans / Q000302:isolation & purification* / Q000378:metabolism / Q000633:toxicity; D007192:Indenes / Q000302:isolation & purification*; D009682:Magnetic Resonance Spectroscopy; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000302:isolation & purification*; D009154:Mutation; D010944:Plants / Q000032:analysis*; D012486:Salmonella typhimurium / Q000187:drug effects; D012717:Sesquiterpenes
D007189:Indans; D007192:Indenes; D009153:Mutagens; D012717:Sesquiterpenes; C043680:ptaquiloside