Immunologic characterization of Reed-Sternberg cells and other cell components in lymph nodes with Hodgkin's disease.
Seven lymph nodes from patients with Hodgkin's disease were immunologically studied. Histologically these cases consisted of 3 lymphocyte predominance, 2 mixed cellularity, and 2 nodular sclerosis. Positive staining of mononuclear Hodgkin- and multinuclear Reed-Sternberg (RS) cells were obtained with anti-Ia like antigens and OKT9 (anti-transferrin receptor) monoclonal antibodies. No supportive data for discussing similarity of RS cells with ordinary histiocytes, B-lymphocytes or T-lymphocytes were obtained from the study of surface phenotype, although some analogy was present with histiocytes. Small lymphocytes around RS cells were helper/inducer T-lymphocytes, and the relationship between these T lymphocytes and RS cells was discussed.
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D002648:Child; D006644:Histiocytes / Q000276:immunology / Q000648:ultrastructure*; D006689:Hodgkin Disease / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology*; D008214:Lymphocytes / Q000276:immunology / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000648:ultrastructure
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface