Gonadotropin-dependent renin in the rat testes.
Using specific anti-rat renal renin antibody, the presence of renin in the rat testis was demonstrated by biochemical determination of renin activity. There was no correlation between testicular and plasma renin activity, indicating independent control of testicular and plasma renin levels. Since specific immunohistochemical staining for renin had been observed exclusively in Leydig cells, the effects of hypophysectomy and gonadotropin treatment on the testicular renin were investigated. After hypophysectomy, renin level in the testis decreased significantly, whereas plasma renin was slightly increased. In contrast, testicular renin had remarkably increased through gonadotropin treatment. The results indicate the presence of gonadotropin-dependent renin in the Leydig cells, and suggest a role for it in regulating testicular functions.
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D007016:Hypophysectomy; D008297:Male; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood / Q000378:metabolism*; D013737:Testis / Q000187:drug effects / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D012083:Renin