title: [Mutagenic effect of the food-coloring agents tartrazine and indigo carmine].
abstract: The authors studied the mutagenic action of the food dyes, tartrazine (both Soviet and imported) and indigocarmine in a microbial model and in warm-blooded animals (linear mice). Determined the toxicity and mutagenic action of the dyes on E. coli, strain K-12, carried out chromosomal analysis of the bone marrow, examined the dominant lethals in CBA X C57BL/6 mice. The recommended daily dose amounts to 400 mg/kg for tartrazine and to 50 mg/kg for indigocarmine with regard to the safety factor equal to 100. The data derived as a result of studying the mutagenic activity of tartrazine manufactured in the USSR and CSSR and indigocarmine paste in 3 experimental models allow the conclusion to be made that the doses of these dyes applied in food industry are fairly safe.
mesh_terms: D000821:Animal Feed / Q000633:toxicity; D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D001853:Bone Marrow / Q000648:ultrastructure; D002869:Chromosome Aberrations; D003470:Culture Media; D004926:Escherichia coli / Q000235:genetics; D005505:Food Coloring Agents / Q000633:toxicity*; D066298:In Vitro Techniques; D007203:Indigo Carmine / Q000633:toxicity*; D007211:Indoles / Q000633:toxicity*; D007621:Karyotyping; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D013645:Tartrazine / Q000633:toxicity*
chemical_list: D001391:Azo Compounds; D003470:Culture Media; D005505:Food Coloring Agents; D007211:Indoles; D009153:Mutagens; D007203:Indigo Carmine; D013645:Tartrazine
vernacular_title: Izuchenie mutagennogo deĭstviia pishchevykh krasiteleĭ tartrazina i indigokarmina.