title: Effect of volume and rate of contrast medium injection on intravenous digital subtraction angiographic contrast medium curves.
abstract: The image quality of temporal (mask mode) intravenous digital subtraction angiography is directly dependent on the shape of arterial time-concentration curves produced by the intravenous injection of contrast medium. Curves that are narrow and tall minimize motion artifact (misregistration) and maximize contrast enhancement (pre- and postcontrast differences). To determine the effects of rate and volume of injection of contrast medium on intravenous digital subtraction angiographic curves, ioxaglate (Hexabrix), a monoacidic ionic dimer, was injected into large mongrel dogs. Quantitative measurements of opacification were made over time in the femoral arteries using a modified General Electric CT/T scanner. Peak opacification was directly proportional to the volume of contrast medium injected. Curve width was not affected by increasing volume of injection. At rates below a critical point, slower injection rates produced progressively shorter and wider arterial time-concentration curves. Above that critical point, increasing the rate of injection did not affect either curve width or curve peak.
mesh_terms: D000792:Angiography / Q000379:methods*; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage*; D004285:Dogs; D005263:Femoral Artery / Q000000981:diagnostic imaging; D006325:Heart Atria / Q000000981:diagnostic imaging; D007275:Injections, Intravenous / Q000379:methods; D007485:Ioxaglic Acid; D013382:Subtraction Technique; D014283:Triiodobenzoic Acids / Q000008:administration & dosage
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007485:Ioxaglic Acid