Desmutagenic substance in water extract of grass-wrack pondweed (Potamogeton oxyphylus Miquel).
It was found that the water extract of grass-wrack pondweed (Potamogeton oxyphylus Miquel) had inhibitory activity for reverse mutations induced by benzo[a]pyrene, 2-aminoanthracene and 2-nitrofluorene with Salmonella typhimurium TA100 and TA98. The active substance was heat-resistant, and the molecular weight was above 300 000. The substance acted as a desmutagen rather than an antimutagen or inhibitor of metabolic activation.
D004305:Dose-Response Relationship, Drug; D006358:Hot Temperature; D008970:Molecular Weight; D009152:Mutagenicity Tests; D009153:Mutagens / Q000037:antagonists & inhibitors*; D009154:Mutation / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects
D009153:Mutagens; D010936:Plant Extracts