title: Bone marrow cell dose and kinetics of recovery following allogeneic marrow transplantation in man.
abstract: In 50 patients transplanted for acute or chronic leukemia we studied the correlation between the number of infused bone marrow cells/kg recipient body weight and the time needed for engraftment. Engraftment was arbitrarily defined as the first day of 1 X 10(9) leukocytes/l and of 20 X 10(9) reticulocytes/l after the posttransplantation nadir. There is a negative non-linear correlation between the duration of leukopenia following marrow transplantation and the amount of transfused nucleated cells (p = 0.01). Since the incidence of infectious or hemorrhagic complications depends directly on the duration of aplasia it is justifiable to give a maximal cell dose.
mesh_terms: D000208:Acute Disease; D016026:Bone Marrow Transplantation; D004306:Dose-Response Relationship, Immunologic; D006098:Granulocytes; D006801:Humans; D007700:Kinetics; D007938:Leukemia / Q000628:therapy; D007945:Leukemia, Lymphoid / Q000628:therapy; D007951:Leukemia, Myeloid / Q000628:therapy; D007958:Leukocyte Count; D012156:Reticulocytes