Immunodepression in Giardia muris and Spironucleus muris infections in mice.
Infections with the intestinal flagellates Giardia muris and Spironucleus muris are accompanied by a depression in the ability of mice to mount an immune response to a thymus-dependent antigen (sheep red blood cells) but not to a thymus-independent antigen (TNP-lipopolysaccharide). The number of splenic IgM plaque-forming cells and haemagglutination titres, of both IgM and IgG, to sheep red blood cells decreased between days 10 and 21, which correlated with the time of maximal trophozoite levels in the small intestine. The number of background IgM plaque-forming cells to sheep red blood cells or DNP was not significantly different from controls in either infection. No evidence for systemic macrophage activation was associated with these infections. In fact, adherent peritoneal exudate cells (PEC) from infected mice were slightly less cytostatic against target tumour cells than adherent PEC from normal mice, at a time when the parasites were being eliminated from the small intestine.
D000818:Animals; D056890:Eukaryota; D005260:Female; D005873:Giardiasis / Q000276:immunology*; D006384:Hemagglutination; D006462:Hemolytic Plaque Technique; D007108:Immune Tolerance; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D011528:Protozoan Infections / Q000276:immunology*
D008070:Lipopolysaccharides