Colostomy irrigation with prostaglandin E2 and bisacodyl. A double-blind cross-over study.
The emptying of the colon and the side-effects after intraluminal application of prostaglandin E2 and of bisacodyl in 14 patients was studied by employing colostomy irrigation. The design was double-blind with cross-over, the irrigation was one litre of tap water to which was added in randomized sequence placebo, prostaglandin *2 (350, 700 and 1400 micrograms) or bisacodyl (1.25, 2.5 and 5 mg). Neither prostaglandin E2 nor bisacodyl had any significant effect.
D000328:Adult; D000368:Aged; D001726:Bisacodyl / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003106:Colon / Q000503:physiopathology; D003125:Colostomy; D003408:Cresols / Q000627:therapeutic use*; D015232:Dinoprostone; D004311:Double-Blind Method; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011458:Prostaglandins E / Q000627:therapeutic use*; D011897:Random Allocation; D007507:Therapeutic Irrigation
D003408:Cresols; D011458:Prostaglandins E; D001726:Bisacodyl; D015232:Dinoprostone