Evidence for the persistence of paramyxoviruses in human bone marrows.
Human bone marrow cells derived from multiple sclerosis (MS) and control patients were screened for a number of virus antigens by the fluorescent antibody technique using monoclonal antibodies. The results showed that antigens of the paramyxovirus, simian virus 5, were present in about 60% of MS and 25% of control bone marrows. About 25% of the MS and 50% of control bone marrows were found to contain nucleoprotein antigen of the human parainfluenza types 1 and 3. These experiments demonstrated that paramyxoviruses can persist in human tissues possibly in a defective or repressed state.
D000818:Animals; D000911:Antibodies, Monoclonal; D000956:Antigens, Viral / Q000032:analysis; D001853:Bone Marrow / Q000382:microbiology*; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D005455:Fluorescent Antibody Technique; D006801:Humans; D007668:Kidney; D009103:Multiple Sclerosis / Q000382:microbiology*; D010252:Paramyxoviridae / Q000302:isolation & purification*
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral