Treatment of male sperm autoimmunity by in-vitro fertilization with washed spermatozoa.
Pregnancies have been achieved in two couples with prolonged infertility in whom no apparent abnormalities were found, except for the presence of seminal plasma autospermagglutinins in the male partners. Using a method previously advocated for artificial insemination by husband, the semen was collected directly into Tyrode's solution and immediately dispersed. After they were washed and resuspended in Tyrode's solution, the spermatozoa were used for the in-vitro fertilization of the wife's ova collected after induced ovulation. In a condition characterized by the difficulty of achieving sperm-ovum contact and interaction, this approach allows close monitoring of all stages of this process and appears to circumvent any expected difficulties.
D000937:Antigen-Antibody Reactions; D001327:Autoimmune Diseases / Q000628:therapy*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D007158:Immunologic Techniques; D007246:Infertility / Q000628:therapy*; D008297:Male; D013094:Spermatozoa / Q000276:immunology