Does prostacyclin prevent cognitive deficits after open heart surgery?
Two groups of open heart surgery patients, one receiving prostacyclin and one placebo, were assessed one week pre-operatively and 3 months post-operatively, using a battery of clinical tests measuring a variety of cognitive functions. No significant differences between the groups were detected, apart from a visual retention deficit at 3 months in the prostacyclin group. The results cast doubt on previous findings suggesting that prostacyclin reduces cognitive deficits following open heart surgery.
D006348:Cardiac Surgical Procedures; D003072:Cognition Disorders / Q000517:prevention & control*; D011464:Epoprostenol / Q000627:therapeutic use*; D006801:Humans; D011183:Postoperative Complications / Q000517:prevention & control; D011581:Psychological Tests
D011464:Epoprostenol