A developmentally regulated disappearance of slow myosin in fast-type muscles of the mouse.
Histochemistry and immunocytochemistry using an antibody to adult rat slow-type myosin demonstrated that about 10% of the fibers in the mouse extensor digitorum longus and semimembranosus muscles contain slow myosin during the first month after birth. In adult animals, these muscles have only 0-08% slow myosin-containing fibers. These results demonstrate a developmentally linked disappearance of an adult-type myosin, and show that the adult phenotype of muscle fibers is not necessarily determined before birth as previously suggested.
D000818:Animals; D000906:Antibodies / Q000276:immunology; D005455:Fluorescent Antibody Technique; D051379:Mice; D008815:Mice, Inbred Strains; D024510:Muscle Development; D009137:Muscular Dystrophy, Animal / Q000473:pathology; D009218:Myosins / Q000032:analysis* / Q000276:immunology; D010641:Phenotype
D000906:Antibodies; D009218:Myosins