Influence of prostaglandin E and reduction of renal arterial pressure on renin release by the dog kidney.
The influence of PGE1 infusion into the renal artery of dogs n renal hemodynamics and renin release (RR) was examined, with or without simultaneous reduction in renal arterial perfusion pressure. The degree of reduction in renal arterial pressure was such as to remain in the autoregulatory range. PGE1 is a known stimulator of RR. The objective of the experiment was to attempt to determine whether or not PGE1 and reduction of renal arterial pressure (baroreceptor mechanisms) operated by a similar receptor-effector mechanism, or by different mechanisms. Evidence is supplied that supports the former case (similar receptor-effector mechanism).
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D011458:Prostaglandins E / Q000494:pharmacology / Q000502:physiology*; D012077:Renal Artery / Q000187:drug effects / Q000502:physiology*; D012083:Renin / Q000378:metabolism*
D011458:Prostaglandins E; D012083:Renin