[Elective detection of thymus epithelium and assessment of the degree of functional and pathological involution of the organ in mice].
With the help of antibodies-containing serum reacting with the thymus reticulum epithelial cells components by immunofluorescence method the thymus parenchimal tissue in mice with functional and pathological involution has been detected electively. In spite of large thymus changes in hairless mice with the mutation of gene hrrhy in 14-th chromosome of B10.R109/Y animals the basal cells antigen in epithelial reticulum has been preserved. It permits to estimate thymus involution level of this organ. Low lymphocyte content in the thymus of C57BL/6 mice is accompanied by total decamouflage of the epithelium. The functional thymus involution of pregnant mice is characterized by the luminescence of large number of epithelial cells, the restoration of organ after the delivery--by their few number. The elective detection of thymus epithelium many serve as additional test for the estimation of functional and pathological involution level.
D000505:Alopecia / Q000276:immunology / Q000503:physiopathology; D000818:Animals; D000906:Antibodies / Q000032:analysis; D000941:Antigens / Q000032:analysis; D004848:Epithelium / Q000276:immunology / Q000503:physiopathology; D005455:Fluorescent Antibody Technique; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D011817:Rabbits; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology / Q000503:physiopathology*
D000906:Antibodies; D000941:Antigens
Elektivnoe vyiavlenie épiteliia timusa i otsenka stepeni funktsional'noĭ i patologicheskoĭ involiutsii organa u mysheĭ.