Early cellular reactions induced by dinitrochlorobenzene in sensitized human skin.
Serial biopsies during the first 24 hours after dinitrochlorobenzene (DNCB) challenge in fifteen sensitized patients have shown that DNCB associates with Langerhans cells within I hour of application, and has reached the dermis around the appendages by 6 hours.
D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D003877:Dermatitis, Contact / Q000276:immunology / Q000473:pathology*; D004137:Dinitrochlorobenzene; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007124:Immunoenzyme Techniques; D007801:Langerhans Cells / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009578:Nitrobenzenes; D010328:Patch Tests; D012867:Skin / Q000276:immunology / Q000473:pathology*; D013997:Time Factors
D000911:Antibodies, Monoclonal; D004137:Dinitrochlorobenzene; D009578:Nitrobenzenes