[Pharmacokinetic studies on ceftazidime in the obstetrical and gynecological field].
Concentrations of ceftazidime ( CAZ ) were examined in the pelvic dead space exudate in 6 patients who received radical hysterectomy due to uterocervical cancer. Data analysis was performed by the simulation curves prepared from pharmacokinetics parameters using the three-compartment model. Following 1-hour intravenous drip infusion of 1 g of CAZ , the mean drug concentration in venous blood was 75.54 micrograms/ml at 1 hour after start of the infusion. The mean CAZ level in the pelvic dead space exudate was as high as 23.87 micrograms/ml at 2.09 hours after start of the infusion, and the AUC was 149.11 micrograms . hr/ml. The above results suggest that CAZ is a useful drug clinically with good penetration into the pelvic dead space.
D002442:Ceftazidime; D002511:Cephalosporins / Q000008:administration & dosage / Q000378:metabolism*; D005122:Exudates and Transudates / Q000378:metabolism; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007263:Infusions, Parenteral; D007700:Kinetics; D008954:Models, Biological; D010388:Pelvis; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000378:metabolism
D002511:Cephalosporins; D002442:Ceftazidime