Diagnostic significance of the human antibody response to a major cytoplasmic antigen of C. albicans.
In contrast to the ubiquitous presence of IgG antibodies to mannan or to crude antigen preparations of C. albicans (CA), antibodies to a purified cytoplasmic antigen (SSF) of CA were detected by ELISA only in patients with candidiasis. The differences of mean absorbancy values found in different groups of sera can allow the distinction of normal sensitized controls from patients with candidiasis and can also distinguish between patients with different degrees of C. albicans invasion.
D000908:Antibodies, Fungal / Q000096:biosynthesis*; D000946:Antigens, Fungal / Q000276:immunology*; D002176:Candida albicans / Q000276:immunology*; D002177:Candidiasis / Q000175:diagnosis* / Q000276:immunology; D003593:Cytoplasm / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans
D000908:Antibodies, Fungal; D000946:Antigens, Fungal