title: [Histogenesis and morphology of the tissues of the rabbit ear chamber--current light and electron microscopy findings].
abstract: The freshly inserted rabbit ear chamber is filled with blood. During the first few days, a fibrin network develops that is deposited mainly on the cover slip and base plate. Fibroblasts from the surrounding tissue invade the chamber migrating on this fibrin scaffold. They change from a rod-like shape into completely flattened cells that produce the connective tissue fibers, and then become hardly recognizable. Centripetal blood vessel sprouting can be observed at the periphery after about 2 weeks. The initial overproduction of vessels is followed by a massive reduction and differentiation. The complete mature vascular system lying between two connective tissue sheets needs about 6--8 weeks to develop. Lymphatics occasionally arise in the same manner, and fat cells occur in individual chambers. The connective tissue is superficially coated with a layer of flattened cells. Aside from other cells (mainly mononuclears). Multinucleated giant cells are found on the cover slip and base plate of the chambers.
mesh_terms: D000818:Animals; D002196:Capillaries / Q000254:growth & development*; D003238:Connective Tissue / Q000098:blood supply / Q000648:ultrastructure*; D004431:Ear, External; D005337:Fibrin / Q000502:physiology*; D005347:Fibroblasts / Q000648:ultrastructure; D006652:Histological Techniques; D008853:Microscopy; D008855:Microscopy, Electron, Scanning; D009000:Monocytes / Q000648:ultrastructure; D011817:Rabbits
chemical_list: D005337:Fibrin
vernacular_title: Histogenese und Morphologie des Gewebes in der Kaninchen-Ohrkammer - neue licht- und elektronenmikroskopische Befunde.