title: Detection of antimicrofilarial ES antigen-antibody in immune complexes in Bancroftian filariasis by enzyme immunoassay.
abstract: An enzyme immunoassay using penicillinase conjugated to Wuchereria bancrofti microfilarial ES antigen has been developed to detect specific antibody in circulating immune complexes in Bancroftian filariasis. Immune complexes were prepared by 3% polyethylene glycol (PEG) precipitation. 44 sera belonging to different groups were tested. 16 of 19 clinical filarial and two of 16 endemic normal sera but none of the non-endemic normal sera showed the presence of antimicrofilarial ES antigen-antibody in immune complexes.
mesh_terms: D000936:Antigen-Antibody Complex / Q000276:immunology*; D005368:Filariasis / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D010405:Penicillinase; D014958:Wuchereria bancrofti
chemical_list: D000936:Antigen-Antibody Complex; D010405:Penicillinase