Effect of the rat liver S9 fraction on the mutagenicity of azathioprine in the Salmonella/mammalian microsome assay.
Azathioprine is a direct acting mutagen in Salmonella typhimurium TA100 and TA1535. Addition of rat liver S9 fraction with or without co-factors, or glutathione, causes a decrease in the mutagenicity of azathioprine in TA100 and an increase in TA1535, indicating the effect of SH groups.
D001379:Azathioprine / Q000037:antagonists & inhibitors / Q000633:toxicity*; D005978:Glutathione / Q000494:pharmacology; D008862:Microsomes, Liver / Q000502:physiology*; D009152:Mutagenicity Tests; D012486:Salmonella typhimurium / Q000235:genetics
D005978:Glutathione; D001379:Azathioprine