Pharmacokinetic approach for reconstruction of predetermined plasma insulin profiles by continuous subcutaneous insulin infusion in depancreatized dogs.
A preprogrammable insulin delivery system which can provide the flexibility of varying plasma insulin concentration in a physiological manner has been developed. This system involves a program of continuous subcutaneous infusion of insulin at variable rates to reproduce arbitrarily selected plasma insulin concentration-time profiles. The desired insulin infusion rate profile was calculated from the desired insulin pattern using pharmacokinetic parameters experimentally determined by measurement of immunoreactive plasma insulin following a subcutaneous bolus dose to depancreatized dogs.
D000042:Absorption; D000818:Animals; D001682:Biological Availability; D004285:Dogs; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage / Q000097:blood*; D007700:Kinetics; D010179:Pancreas / Q000502:physiology*; D010180:Pancreatectomy
D007328:Insulin