Effect of an irradiated Escherichia coli endotoxin reparation on the sensitivity to a lymphotropic cytostatic agent in germfree and conventional mice.
A 18 mg/kg dose of dianhydrodulcitol, a lymphotropic cytostatic agent produced the same death rate among germfree as a 12 mg/kg dose did in conventional mice. Pretreatment with the same dose of an irradiated immunomodulatory endotoxin preparation had increased the sensitivity to these dianhydrodulcitol doses in the same degree in germfree as in conventional mice. A study of the lymphoid organs and the intestinal wall indicate that both in germfree and conventional mice the dianhydrodulcitol sensitivity increasing effect of the endotoxin preparation was due to its stimulation of the lymphoid system. The higher resistance of germfree mice to dianhydrodulcitol is ascribed to their lack of a normal intestinal flora.
D000818:Animals; D003961:Dianhydrogalactitol / Q000494:pharmacology*; D004731:Endotoxins / Q000276:immunology / Q000528:radiation effects*; D004926:Escherichia coli / Q000276:immunology*; D005260:Female; D005856:Germ-Free Life / Q000187:drug effects; D007421:Intestine, Small / Q000187:drug effects / Q000276:immunology; D008208:Lymphatic System / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D009929:Organ Size; D010567:Pertussis Vaccine / Q000276:immunology; D013154:Spleen / Q000033:anatomy & histology / Q000502:physiology; D013402:Sugar Alcohols / Q000494:pharmacology*; D013950:Thymus Gland / Q000033:anatomy & histology / Q000502:physiology
D004731:Endotoxins; D010567:Pertussis Vaccine; D013402:Sugar Alcohols; D003961:Dianhydrogalactitol; C010797:tolerin