title: Comparison of gastrointestinal blood loss induced by cloximate in two formulations and by naproxen.
abstract: In a double-blind baseline controlled crossover trial gastrointestinal blood loss induced by cloximate in two different formulations (enteric-coated and non-enteric coated) was compared with naproxen. Gastrointestinal blood loss increased more in the naproxen group (0.41 ml/24 h) than in the group treated with non-enteric coated cloximate. The group treated with coated cloximate had a higher mean increase in gastrointestinal blood loss (0.36 ml/24 h) compared with placebo than those treated with non-coated cloximate.
mesh_terms: D000085:Acetates / Q000009:adverse effects*; D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D008297:Male; D009288:Naproxen / Q000009:adverse effects*; D011897:Random Allocation; D013608:Tablets, Enteric-Coated
chemical_list: D000085:Acetates; D013608:Tablets, Enteric-Coated; C039695:cloximate; D009288:Naproxen