title: Saccharomyces cerevisiae produces a yeast substance that exhibits estrogenic activity in mammalian systems.
abstract: Partially purified lipid extracts of Saccharomyces cerevisiae contain a substance that displaces tritiated estradiol from rat uterine cytosol estrogen receptors. The yeast product induces estrogenic bioresponses in mammalian systems as measured by induction of progesterone receptors in cultured MCF-7 human breast cancer cells and by a uterotrophic response and progesterone receptor induction after administration to ovariectomized mice. The findings raise the possibility that bakers' yeast may be a source of environmental estrogens.
mesh_terms: D000818:Animals; D001681:Biological Assay; D001943:Breast Neoplasms / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D004967:Estrogens / Q000096:biosynthesis* / Q000494:pharmacology; D005260:Female; D006801:Humans; D051379:Mice; D011980:Receptors, Progesterone / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D014599:Uterus / Q000187:drug effects
chemical_list: D004967:Estrogens; D011980:Receptors, Progesterone; D004958:Estradiol