Pathophysiology of renovascular hypertension.
Studies of the renin-angiotension system and the effects of pharmacologic blockade have enhanced our understanding of renovascular hypertension. A critical degree of arterial stenosis produces kidney ischemia sufficient to activate this hormonal system, whose actions include vasoconstriction and sodium retention. Accurate clinical evaluation may depend upon recognizing the differences in pathophysiology between "one-kidney" and "two-kidney" forms and the dynamic nature of this condition.
D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D001794:Blood Pressure; D006801:Humans; D006978:Hypertension, Renovascular / Q000378:metabolism / Q000503:physiopathology*; D007668:Kidney / Q000503:physiopathology*; D009318:Natriuresis; D051381:Rats; D012078:Renal Artery Obstruction / Q000378:metabolism / Q000503:physiopathology; D012079:Renal Circulation; D012083:Renin / Q000502:physiology; D012084:Renin-Angiotensin System; D012964:Sodium / Q000378:metabolism; D014661:Vasoconstriction
D000804:Angiotensin II; D012964:Sodium; D012083:Renin