[Complement, granulocytes and pulmonary capillaries].
The activation, aggregation and adhesion of polymorphonuclear leukocytes on the endothelial wall of the pulmonary capillaries are responsible for lesions of variable severity on the alveolar-capillary membrane. The mechanism and the contribution of this leukocyte aggregation was studied to explain the respiratory abnormalities observed during the course of haemodialysis, leukapharesis and the end of extra-corporeal circulation. The activation of complement, by the formation of C5a is probably the initiator of this phenomenon. Based on these experimental models, the varied steps in the intra-capillary aggregation of leukocytes is envisaged as an explanation for the lesions in the acute respiratory distress syndrome, alveolitis caused by immune complexes and pulmonary toxicity caused by oxygen. Corticosteroids may inhibit leukocyte aggregation under certain conditions. These studies allow for a more precise pathophysiological approach for the use of steroids in their disorders.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology; D002196:Capillaries / Q000503:physiopathology; D002449:Cell Aggregation; D003167:Complement Activation / Q000187:drug effects; D003182:Complement C5 / Q000276:immunology; D015936:Complement C5a; D004546:Elapid Venoms / Q000494:pharmacology; D005112:Extracorporeal Circulation / Q000009:adverse effects; D006801:Humans; D066298:In Vitro Techniques; D007937:Leukapheresis / Q000009:adverse effects; D051379:Mice; D009504:Neutrophils / Q000201:enzymology / Q000502:physiology*; D011650:Pulmonary Alveoli / Q000098:blood supply*; D006435:Renal Dialysis / Q000009:adverse effects; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000503:physiopathology*; D065227:Transfusion Reaction
D000305:Adrenal Cortex Hormones; D000936:Antigen-Antibody Complex; D003182:Complement C5; D004546:Elapid Venoms; C016310:cobra venom factor; D015936:Complement C5a
Complément, granulocytes et capillaires pulmonaires.