Ketonuria does not exclude hyperinsulinemic hypoglycemia.
We examined the relationship between serum beta-hydroxybutyrate (BOHB) and plasma glucose concentrations and between serum free fatty acid (FFA) and glucose concentrations in 34 normal children who fasted for up to 24 hours. The BOHB concentration correlated inversely with the glucose concentration, as did the FFA concentration. We compared these results with those in six patients with hypoglycemia due to hyperinsulinism. In the hyperinsulinemic children, hypoglycemia was invariably associated with relative hypoketonemia (glucose concentration, less than 40 mg/dL; BOHB concentration, less than 2mM; greater than 2 SDs below the mean). The FFA concentrations were also unduly low (greater than 2 SDs). However, despite being significantly hypoketonemic when hypoglycemic, four of the six hyperinsulinemic patients had ketonuria. Since it does not exclude hyperinsulinism, ketonuria may be a potentially misleading finding in a hypoglycemic child.
D020155:3-Hydroxybutyric Acid; D000293:Adolescent; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D007003:Hypoglycemia / Q000378:metabolism*; D007223:Infant; D007328:Insulin / Q000097:blood*; D007657:Ketone Bodies / Q000097:blood / Q000652:urine*; D008297:Male
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D007328:Insulin; D007657:Ketone Bodies; D020155:3-Hydroxybutyric Acid