The mode of action of zaluzanin C, an inhibitor of translation in eukaryotes.
Zaluzanin C, a substance extracted from several species of the genus Zaluzania (Compositae), has been shown to inhibit protein synthesis in intact HeLa cells preferentially to DNA and RNA synthesis. "In vitro" protein synthesis was also blocked by zaluzanin C and the study of the effects of the drug on resolved model systems indicates that it inhibits enzymic translocation of peptidyl-tRNA specifically.
D000818:Animals; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D011132:Polyribosomes / Q000378:metabolism; D014176:Protein Biosynthesis / Q000187:drug effects*; D012346:RNA, Transfer, Amino Acyl / Q000378:metabolism; D011817:Rabbits; D012156:Reticulocytes / Q000378:metabolism; D012270:Ribosomes / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism; D012717:Sesquiterpenes / Q000494:pharmacology*; D045789:Sesquiterpenes, Guaiane
D012346:RNA, Transfer, Amino Acyl; D012717:Sesquiterpenes; D045789:Sesquiterpenes, Guaiane; C000621518:zaluzanin C