Etiopathogenesis of otosclerosis: a hypothesis.
It is hypothesized that otosclerosis is an autoimmune disease in response to native type II collagens of cartilage rests associated with globular ossei in the endochondral layer of the otic capsule. To support this hypothesis animal experimental data and human antibody data are shown.
D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology*; D003094:Collagen / Q000276:immunology*; D004285:Dogs; D006801:Humans; D051379:Mice; D010040:Otosclerosis / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D051381:Rats
D001323:Autoantibodies; D003094:Collagen