title: Interaction between murine natural killer cells and trypanosomes of different species.
abstract: The involvement of natural killer (NK) cells in the immunological resistance of mice to murine-specific Trypanosoma musculi was evaluated. Murine NK cells were found to be unable to kill or inhibit T. musculi or to protect recipients from infection. In addition, the ability of spleen cells from normal mice and from mice on day 3 of T. musculi infection, at the time of maximum NK augmentation, to kill Trypanosoma cruzi and Trypanosoma lewisi was evaluated. Spleen cells from normal mice displayed significant killing of both T. cruzi and T. lewisi. Furthermore, augmented spleen cells from T. musculi-infected mice were considerably more effective than normal spleen cells in killing both T. cruzi and T. lewisi. The activity of NK cells toward YAC-1 tumor target cells was inhibited in a dose-dependent fashion by either live T. musculi or extracts of T. musculi, but not by extracts of rat-specific T. lewisi. The results suggest that well-adapted protozoan parasites may be nonsusceptible to the natural cell-mediated resistance mechanisms of their hosts. Their nonsusceptibility could result from the ability to elaborate substances that either inactivate NK cells or block NK cell interaction with complementary sites on the parasite surface.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D013045:Species Specificity; D014345:Trypanosoma / Q000276:immunology*; D014349:Trypanosoma cruzi / Q000276:immunology; D014350:Trypanosoma lewisi / Q000276:immunology; D014352:Trypanosomiasis / Q000276:immunology