Plasmodium falciparum takes up iron from transferrin.
Plasmodium falciparum, cultured in vitro, is inhibited by desferrioxamine, a specific iron chelating agent, despite the abundant haem iron which surrounds the parasite. In this report we show that the intraerythrocytic parasite obtains iron from transferrin. The parasite may therefore be freed of a requirement to catabolize haem to obtain iron thus minimizing haem toxicity.
D000818:Animals; D001059:Apoproteins; D004912:Erythrocytes / Q000469:parasitology; D006801:Humans; D007501:Iron / Q000378:metabolism*; D010963:Plasmodium falciparum / Q000378:metabolism*; D014168:Transferrin / Q000378:metabolism*
D001059:Apoproteins; D014168:Transferrin; C028284:apotransferrin; D007501:Iron