Defective regulation of the immune response to tetanus toxoid in Hashimoto's disease.
The humoral immune response to tetanus toxoid has been studied in patients with Hashimoto's disease. Although the magnitude of the response was similar to that observed in normal subjects, the Hashimoto patients demonstrated an inability to regulate their levels of tetanus toxoid antibody. This apparent defect in the control of antibody synthesis may be an important factor in both the initiation and perpetuation of autoimmune thyroid disease.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000096:biosynthesis* / Q000145:classification; D001323:Autoantibodies / Q000145:classification; D001327:Autoimmune Diseases / Q000276:immunology*; D003017:Clostridium tetani / Q000276:immunology; D005260:Female; D006801:Humans; D007114:Immunization; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000145:classification; D007700:Kinetics; D008875:Middle Aged; D013745:Tetanus Toxoid / Q000276:immunology*; D013961:Thyroid Gland / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000276:immunology*
D000907:Antibodies, Bacterial; D001323:Autoantibodies; D007074:Immunoglobulin G; D013745:Tetanus Toxoid