Inhibition of insulin hyperphagia by gamma aminobutyric acid antagonists in rats.
The effects of GABA antagonists, picrotoxin and bicuculline were studied on hyperphagia caused by insulin in free feeding rats. It was found that peripheral administration of GABA antagonists inhibited this hyperphagia. These agents were administered in the VMH and LH through stereotaxically implanted cannulae. It was found that the food intake was inhibited when injected into the VMH, but not in the LH. These findings suggest that LH plays a relatively passive role as compared to VMH, where GABA appears to be an important neurotransmitter.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D001786:Blood Glucose / Q000502:physiology; D004435:Eating / Q000187:drug effects*; D018756:GABA Antagonists; D007031:Hypothalamus / Q000502:physiology; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D001640:Bicuculline; D001786:Blood Glucose; D018756:GABA Antagonists; D007328:Insulin; D010852:Picrotoxin