Methenamine mandelate with acidification: an effective urinary antiseptic in patients with neurogenic bladder.
We studied the effectiveness of methenamine mandelate in preventing urinary tract infection in patients with neurogenic bladder dysfunction who were in a program of intermittent catheterization and bladder retraining. Nine of 17 patients (53%) became infected while receiving the drug, whereas 19 of 22 patients (86%) in a placebo group became infected during the trial. The difference in infection rates was statistically significant (P less than 0.02) and resulted primarily from the absence of gram-positive cocci and Pseudomonas species in the drug group.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000643:Ammonium Chloride / Q000008:administration & dosage* / Q000627:therapeutic use; D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D005260:Female; D005557:Formaldehyde / Q000652:urine; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D008297:Male; D008333:Mandelic Acids / Q000008:administration & dosage* / Q000627:therapeutic use; D008709:Methenamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000517:prevention & control; D011897:Random Allocation; D013997:Time Factors; D001750:Urinary Bladder, Neurogenic / Q000150:complications*; D014546:Urinary Catheterization; D014552:Urinary Tract Infections / Q000517:prevention & control*
D000892:Anti-Infective Agents, Urinary; D008333:Mandelic Acids; D000643:Ammonium Chloride; D005557:Formaldehyde; C023055:methenamine mandelate; D008709:Methenamine