Modulation of chemical carcinogenesis by xenobiotics.
Xenobiotics enhance and inhibit chemical carcinogenesis by a variety of mechanisms through effects at different steps in the overall process, including modification of carcinogen availability, biotransformation, reactive interactions, expression of cellular alteration, and neoplastic development. Importantly, the same agent can be both an enhancer or an inhibitor depending upon the circumstance of its interaction with the carcinogen.
D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000378:metabolism / Q000633:toxicity*; D003043:Cocarcinogenesis; D004247:DNA / Q000378:metabolism; D004347:Drug Interactions; D005609:Free Radicals; D005786:Gene Expression Regulation; D006801:Humans; D009369:Neoplasms / Q000139:chemically induced* / Q000503:physiopathology; D051381:Rats
D002273:Carcinogens; D005609:Free Radicals; D004247:DNA