title: Chronic intracerebroventricular infusion of insulin causes selective increase of slow wave sleep in rats.
abstract: Sleep patterns were continuously recorded in rats receiving chronic intracerebroventricular (i.c.v.) infusions of insulin. The i.c.v. administration of insulin resulted in a selective increase (25%) of the daily duration of slow wave sleep (SWS), whereas the duration of paradoxical sleep (PS) remained unchanged. The neutralization of peripheral and/or central insulin by means of continuous intravenous or i.c.v. infusions of anti-insulin serum brought about a selective decrease of SWS, whereas PS remained unchanged. The present findings are discussed with regard to the present knowledge of the origin and the role of brain insulin.
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D007328:Insulin / Q000494:pharmacology* / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012894:Sleep Stages / Q000187:drug effects* / Q000502:physiology; D012895:Sleep, REM / Q000187:drug effects
chemical_list: D007328:Insulin