Antibiotic sensitivities of urinary pathogens, 1971-82.
All urinary pathogens from general practice and from hospital have been tested for sensitivity to a range of antimicrobial drugs for the last 12 years. During that period there have been marked changes. In general practice there has been a marked increase in the proportion of staphylococcal infections, from 5.1% to 14.8%, and a noticeable decrease in the proportion caused by Proteus mirabilis, from 9.2% to 4.1%. Similar, but smaller, changes have been seen in the proportions of hospital UTI caused by those organisms, while the proportion of hospital infections due to Klebsiella-Enterobacter spp. has fallen from 16.8% to 8.3%. These, and other, changes have been reflected in changing antibiotic sensitivity patterns. In particular, sensitivity of urinary pathogens to ampicillin/amoxycillin and to cephaloridine has continued to fall both in general practice and in hospital. In general practice UTI nalidixic acid-resistance is becoming more important as the proportion of Gram-positive urinary pathogens increases. There has been little change in sensitivity to trimethoprim or co-trimoxazole over the last 12 years.
D000658:Amoxicillin / Q000494:pharmacology; D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002509:Cephaloridine / Q000494:pharmacology; D004338:Drug Combinations / Q000494:pharmacology; D004927:Escherichia coli Infections / Q000382:microbiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D011513:Proteus mirabilis / Q000187:drug effects; D013420:Sulfamethoxazole / Q000494:pharmacology; D013997:Time Factors; D014295:Trimethoprim / Q000494:pharmacology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014552:Urinary Tract Infections / Q000382:microbiology*
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D000667:Ampicillin; D000658:Amoxicillin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole; D002509:Cephaloridine