[Genetic control of the modification of the radiosensitivity of yeasts by oxygen and hypoxic sensitizers].
Diploid cells of the wild-type yeast Saccharomyces cerevisiae, mutants homozygous with respect to rad2 and rad54 loci as well as a double mutant with both these loci in homozygous state were used to demonstrate the previously observed (in other yeast strains) genetic determination of radiosensitivity modification of hypoxic cells by oxygen and electron-affinic compounds. It was shown that both oxygen effect and the effect of hypoxic sensitizers depended on the activity of repair systems. A possible mechanism of participation of postradiation recovery in modification of yeast cell radiosensitivity is discussed.
D000693:Anaerobiosis / Q000187:drug effects / Q000528:radiation effects; D004171:Diploidy; D004583:Electrons; D005838:Genotype; D009154:Mutation; D010100:Oxygen / Q000494:pharmacology*; D011836:Radiation Tolerance; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects
D011838:Radiation-Sensitizing Agents; D010100:Oxygen
Geneticheskiĭ kontrol' modifikatsiĭ radiochuvstvitel'nosti drozhzheĭ kislorodom i gipoksicheskimi sensibilizatorami.