title: Cardiac dysrhythmias and heart rate changes at induction of anaesthesia: a comparison of two intravenous anticholinergics.
abstract: Glycopyrrolate, 0.2 mg, or atropine, 0.6 mg, was administered intravenously together with methohexitone for the induction of anaesthesia in unpremedicated patients. The use of atropine, compared with glycopyrrolate, was associated with a greater rise in heart rate, a greater number of patients whose heart rates doubled, and a higher incidence of dysrhythmias. Glycopyrrolate is recommended for use as an intravenous anticholinergic agent, particularly in patients with cardiovascular impairment.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D001285:Atropine / Q000008:administration & dosage / Q000009:adverse effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004562:Electrocardiography; D005260:Female; D006024:Glycopyrrolate / Q000008:administration & dosage / Q000009:adverse effects; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008723:Methohexital / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D010276:Parasympatholytics / Q000008:administration & dosage / Q000009:adverse effects*; D011897:Random Allocation
chemical_list: D010276:Parasympatholytics; D001285:Atropine; D008723:Methohexital; D006024:Glycopyrrolate