Threshold of airway response to inhaled methacholine in healthy men and women.
Threshold of airway response to inhaled methacholine was determined using maximum expiratory partial flow-volume curves in 21 men and 36 women with similar age distribution, all of them healthy nonsmokers. Mean threshold was on average 1.3 doubling dose lower in women than men. There were no sex differences in the increase of maximum expiratory flows after a full inspiration when the airways were constricted by methacholine.
D000293:Adolescent; D000328:Adult; D000336:Aerosols; D004056:Differential Threshold; D005260:Female; D006801:Humans; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000008:administration & dosage* / Q000494:pharmacology; D008875:Middle Aged; D012129:Respiratory Function Tests; D012137:Respiratory System / Q000187:drug effects*; D012737:Sex Factors; D014109:Total Lung Capacity; D014797:Vital Capacity
D000336:Aerosols; D008688:Methacholine Compounds; D016210:Methacholine Chloride