Attempts at cultivation of Mycobacterium leprae in macrophages from susceptible animal hosts.
Macrophages from nude mice, nude rats, and armadillos were cultured in vitro and examined for their ability to support Mycobacterium leprae. No significant growth of this organism were observed after over 200 days of culture. No significant benefit was derived from modifying culture conditions or from variations in the source of macrophages or the source of M. leprae.
D000818:Animals; D001202:Ascitic Fluid / Q000382:microbiology; D001431:Bacteriological Techniques; D001853:Bone Marrow / Q000382:microbiology; D003470:Culture Media; D006801:Humans; D008264:Macrophages / Q000382:microbiology*; D051379:Mice; D008819:Mice, Nude; D009166:Mycobacterium leprae / Q000254:growth & development*; D051381:Rats
D003470:Culture Media