title: Ultrastructural, immunohistological, and clinical findings in the pancreas in insulin-dependent diabetes mellitus (IDDM) of long duration.
abstract: Electron microscopical and immunohistological findings in small biopsies obtained at surgery from two subjects with longstanding type-I-diabetes [insulin-dependent diabetes mellitus (IDDM)] are described and demonstrated in relation to clinical data. The main findings are the first electron microscopical demonstration of A cells scattered as single cells in the exocrine pancreatic tissue and the detection of intermediate cells of the acinar-A cell type. Intermediate cells have never been reported before in the pancreas of diabetes in man.
mesh_terms: D000368:Aged; D002096:C-Peptide / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000473:pathology*; D005260:Female; D005934:Glucagon / Q000097:blood; D005951:Glucose Tolerance Test; D006801:Humans; D007515:Islets of Langerhans / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010179:Pancreas / Q000648:ultrastructure*
chemical_list: D002096:C-Peptide; D005934:Glucagon