Corneal sensitivity after epikeratophakia.
Corneal sensitivity was tested in 60 eyes of 30 patients who underwent unilateral epikeratophakia for the correction of aphakia (20 patients) or keratoconus (10 patients). Postoperative recovery time ranged from 2 months to 21 months (mean: 10 months). Our results indicate a relative hypesthesia of the epikeratophakia lenticule when compared with the peripheral host cornea and contralateral control cornea. However, corneal sensitivity tested in 11 patients with more than 1 year follow-up was increased compared with the sensitivity of 19 patients whose postoperative recovery was less than 1 year. Histopathologic findings in two lenticules from a nonhuman primate demonstrated sparse epithelial axon terminals. Host corneal nerves appear to innervate the lenticules by intraepithelial extension and by penetration of the superficial keratectomy scar.
D000818:Animals; D001035:Aphakia / Q000601:surgery*; D003315:Cornea / Q000294:innervation*; D016039:Corneal Transplantation; D004848:Epithelium / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007640:Keratoconus / Q000601:surgery*; D007908:Lens, Crystalline / Q000294:innervation; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000473:pathology; D011184:Postoperative Period; D012677:Sensation / Q000502:physiology