title: The genetics of hormonal influences on male sexual behavior of mice and rats.
abstract: This review focuses on the intersection of genes and hormones as they relate to the development of male sexual behavior. Three major hypotheses are discussed: (1) Some differences in adult male sexual behavior are due to gene differences that influence brain differentiation. Genes that influence brain differentiation may do so by affecting the elaboration of testosterone (i.e., H-Y antigen) or the sensitivity to testosterone (i.e., Tfm mutation and autosomal variations) during neonatal and/or prenatal life. (2) Some differences in male sexual behavior are due to gene differences that influence adult levels of testosterone or sensitivity to testosterone and its metabolites. (3) There is a gene(s) on the Y chromosome that influences the development of sexual behavior that is associated with the arousal mechanism. A possible hormonal mechanism of this Y chromosomal gene(s) is discussed.
mesh_terms: D013734:Androgen-Insensitivity Syndrome / Q000235:genetics / Q000503:physiopathology; D000818:Animals; D001921:Brain / Q000254:growth & development*; D003307:Copulation / Q000502:physiology; D004542:Ejaculation; D005260:Female; D006182:H-Y Antigen / Q000032:analysis; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics; D011187:Posture; D051381:Rats; D012727:Sex Characteristics; D012726:Sexual Behavior, Animal / Q000502:physiology*; D013045:Species Specificity; D013739:Testosterone / Q000235:genetics* / Q000502:physiology; D014960:X Chromosome; D014998:Y Chromosome
chemical_list: D006182:H-Y Antigen; D013739:Testosterone