Suppression of follicular trapping of antigen-antibody complexes in mice treated with anti-IgM or anti-IgD antibodies from birth.
Mice were treated from birth with either goat anti-mouse IgM or with a monoclonal anti-IgD antibody. When they were 8 weeks old, cohorts of these mice were given 125I-labelled antigen, either by itself, or in an antigen-antibody complex. Anti-IgM-treated mice, which did not develop follicular structures in their spleens, failed to retain immune complexes on follicular dendritic cells in the characteristic pattern. Anti-IgD-treated mice, which had small follicles consisting of IgM+ IgD- B cells in their spleens, retained substantially smaller amounts of immune complexes than normal. These results support the concept that B lymphocytes transport antigen-antibody complexes to follicular dendritic cells. Furthermore, in the mouse it seems likely that this is mediated by both IgM+ IgD+ and IgM+ IgD- B cells.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D000938:Antigen-Presenting Cells / Q000166:cytology / Q000276:immunology*; D001345:Autoradiography; D001402:B-Lymphocytes / Q000276:immunology*; D001693:Biological Transport, Active; D007124:Immunoenzyme Techniques; D007072:Immunoglobulin D / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology*; D008212:Lymphocyte Depletion; D051379:Mice; D008809:Mice, Inbred C3H; D013154:Spleen / Q000166:cytology / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D000936:Antigen-Antibody Complex; D007072:Immunoglobulin D; D007075:Immunoglobulin M