Induction of ovulation with pulsatile LH-RH in infertile women.
In five women who had demonstrated repeatedly ovulatory cycles with insufficient luteal phases ovulation was supported by continuous intermittent administration of LH-RH, 5 micrograms per 90 min, intravenously by means of a portable pump. All 18 induced cycles were ovulatory. The production of progesterone rose by 75% to 51 nM/l during the midluteal phase. The duration of the luteal phase increased with 49% to 14 days. One patient became pregnant, but aborted spontaneously 20 days postovulatory. The only major side effect seen was an occasional superficial thrombophlebitis.
D000328:Adult; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy* / Q000503:physiopathology; D007263:Infusions, Parenteral; D008183:Luteal Phase / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects*; D011374:Progesterone / Q000097:blood
D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone