The mononuclear phagocyte system of the mouse defined by immunohistochemical localization of antigen F4/80: macrophages of bone and associated connective tissue.
The macrophage-specific antigen F4/80 has been localized in adult mouse bone and connective tissue. F4/80 positive cells form the centre of haemopoietic islands, line the periosteal and subendosteal bone surfaces and are a major component of connective tissue and the synovial membrane (presumptive type A cells). F4/80 is absent from fibroblasts, chondrocytes, osteoblasts, osteocytes, osteoclasts and a subpopulation of synovial lining cells (presumptive type B cells).
D000818:Animals; D000941:Antigens / Q000032:analysis*; D001842:Bone and Bones / Q000276:immunology*; D003238:Connective Tissue / Q000276:immunology*; D007124:Immunoenzyme Techniques; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010010:Osteoclasts / Q000276:immunology; D013583:Synovial Membrane / Q000276:immunology
D000941:Antigens