In vitro antibacterial activity of the combination of clindamycin and ceftazidime.
A total of 49 anaerobic and 52 aerobic or facultative bacteria were tested for their susceptibilities to clindamycin and ceftazidime alone and in combination. Synergy was noted for 11 strains, whereas antagonism was not detected. The combination of clindamycin and ceftazidime may prove to be useful for the treatment of severe mixed infections caused by anaerobes and aerobes or facultative bacteria.
D001419:Bacteria / Q000187:drug effects*; D002442:Ceftazidime; D002511:Cephalosporins / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology*; D004338:Drug Combinations; D004357:Drug Synergism; D006089:Gram-Negative Anaerobic Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013210:Staphylococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects
D002511:Cephalosporins; D004338:Drug Combinations; D002981:Clindamycin; D002442:Ceftazidime