title: Effect of ibuprofen, naproxen sodium and paracetamol on intrauterine pressure and menstrual pain in dysmenorrhoea.
abstract: The effects of ibuprofen (400 mg), naproxen sodium (250 mg) and paracetamol (500 mg) on intrauterine pressure and menstrual pain was assessed in 12 women with dysmenorrhoea in a double-blind parallel study. Intrauterine pressure was recorded with a microtransducer catheter for 4 h and resting pressure, active pressure, frequency of pressure cycles and the area under the curve were analysed in 30-min periods. Ibuprofen, in a single oral dose of 400 mg, significantly reduced resting pressure, active pressure, the frequency of pressure cycles and the area under the curve and this was associated with a significant reduction in pain intensity. Neither paracetamol nor naproxen sodium effected significant changes in intrauterine pressure or pain score.
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use*; D000328:Adult; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004412:Dysmenorrhea / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use*; D009288:Naproxen / Q000627:therapeutic use*; D010146:Pain; D011312:Pressure; D014599:Uterus / Q000503:physiopathology
chemical_list: D000082:Acetaminophen; D009288:Naproxen; D007052:Ibuprofen