Effect of metoprolol on 24-hour urinary excretion of adrenal steroids and kallikrein in patients with essential hypertension.
Treatment of fifteen patients with essential hypertension over four weeks using the beta 1-adrenoceptor blocking agent, metoprolol, resulted in a decrease in 24 h urinary excretion of kallikrein and aldosterone along with a decrease in plasma renin activity. There was no significant change in 24 h excretion rates of the free adrenal steroids deoxycorticosterone, 18-OH-deoxycorticosterone, corticosterone, cortisol or 18-OH-corticosterone during treatment, which were not significantly different from excretion rates of normal males, thus excluding inhibitory effects of adrenal steroids on urinary kallikrein activity. A positive correlation was found between plasma renin activity and urinary excretion of kallikrein during the control period and after 2 weeks on metoprolol, supporting the assumption of a preserved link between the renin-angiotensin-aldosterone system and the renal excretion of kallikrein in these patients. The decrease in kallikrein excretion during beta 1-adrenoceptor blockade in patients with essential hypertension may be explained by a reduction in sympathetic tone and by reduced activity of the renin-aldosterone system.
D015069:18-Hydroxycorticosterone / Q000652:urine; D015070:18-Hydroxydesoxycorticosterone / Q000652:urine; D000305:Adrenal Cortex Hormones / Q000652:urine*; D000328:Adult; D000450:Aldosterone / Q000652:urine; D003345:Corticosterone / Q000652:urine; D003900:Desoxycorticosterone / Q000652:urine; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D006973:Hypertension / Q000188:drug therapy* / Q000652:urine; D007610:Kallikreins / Q000652:urine*; D008790:Metoprolol / Q000627:therapeutic use*; D012083:Renin / Q000097:blood
D015070:18-Hydroxydesoxycorticosterone; D000305:Adrenal Cortex Hormones; D003900:Desoxycorticosterone; D000450:Aldosterone; D015069:18-Hydroxycorticosterone; D007610:Kallikreins; D012083:Renin; D008790:Metoprolol; D003345:Corticosterone; D006854:Hydrocortisone