title: Response of esthesioneuroblastoma to chemotherapy. Report of five cases and review of the literature.
abstract: Five patients with advanced stage or metastatic esthesioneuroblastoma treated with chemotherapy are reported, and another eight cases found in the literature are reviewed. In this collective experience with chemotherapy in this disease, the authors found that 8 of 13 patients (62%) had an objective response to chemotherapy. The agents which may be active in this disease and the role of chemotherapy, particularly adjuvant therapy for patients presenting with advanced disease, are discussed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002648:Child; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004341:Drug Evaluation; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000188:drug therapy*; D011241:Prednisone / Q000008:administration & dosage; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D008466:Mechlorethamine; D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone