[The theory and practice of chemotherapy by arterial infusion--the importance of pharmacokinetic research].
Chemotherapy using arterial infusion was employed to introduce an anti-cancer drug directly into the arteries which nourish the tumor, thereby distributing a high concentration of the drug to the tumor, increasing the anti-tumor effect and reducing the amount of the drug in circulation throughout the body, thus mitigating its side effects. However, the uptake of the anti-cancer drug into the tumor and its distribution throughout the body are influenced by a large number of factors: the method or route of administering the anti-cancer drug; rate of infusion; local blood flow; permeability of the blood vessels; structure and affinity of the drug; the metabolism of the drug and the speed of its breakdown and elimination. As long as this kind of pharmacokinetics is involved, the principal merit of the arterial-infusion chemotherapy is that the first time the drug is circulated, a high concentration is distributed to the arteries which feed the tumor. However, there is a great deal as yet unknown about the peculiarities and variability of anti-cancer drugs and the internal organs.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000378:metabolism; D002199:Capillary Permeability; D003110:Colonic Neoplasms / Q000188:drug therapy; D004317:Doxorubicin / Q000008:administration & dosage / Q000378:metabolism; D006801:Humans; D007261:Infusions, Intra-Arterial; D007700:Kinetics; D008727:Methotrexate / Q000008:administration & dosage / Q000378:metabolism; D009369:Neoplasms / Q000098:blood supply / Q000188:drug therapy* / Q000378:metabolism; D013274:Stomach Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D004317:Doxorubicin; D008727:Methotrexate