[Glucose tolerance and insulin secretion in relation to age in type-II diabetes--a contribution to the pathogenesis of type-II diabetes mellitus].
It is reported on investigations carried through between age at manifestation of a type II diabetes and stimulated insulin secretion. In a group of 130 recently manifested diabetics and non selected diabetics no differences between insulin secretion, stimulated by glucose (orally given) and glucagon could be found when we compared the resulted in dependence on the age. Patients were grouped in four classes of age: less than 50, 51 less than or equal to 60, 61 less than or equal to 70, greater than 70. Similar results of insulin secretion were to be seen as well in a group of diabetics, selected at random, when glucose-, tolbutamide- and glucagon stimulation of insulin secretion were evaluated as in patients first examined after longer diabetes duration (about 6,5 years, n = 51). The entire insulin secretion after all three stimuli was nearly identical with those of probands, who were examined immediately after the manifestation and 5 years later (n = 34). In diabetics both in investigations at the manifestation of the disease and after prolonged diabetes and in follow-up studies wee found no hints, that with progressing age and disease a reduction of insulin secretion in the type II develops. These findings contradict the assumption that a permanent hyperglycemic stimulus provokes a gradual loss of the B-cell function. With the manifestation of the disease already a change of the B-cell function seems to exist which remains constant in nearly the same degree. A possibly concomitant physiological process of aging evidently does not significantly influence the remaining function of the B-cells. The disturbed insulin secretion and the insulin resistance in type II diabetes seem to processes developing in parallel, which are being on the same pathogenetic principle.
D000368:Aged; D000375:Aging; D001786:Blood Glucose / Q000032:analysis*; D001835:Body Weight; D003924:Diabetes Mellitus, Type 2 / Q000209:etiology* / Q000503:physiopathology; D005934:Glucagon; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007330:Insulin Antibodies / Q000032:analysis; D000078790:Insulin Secretion; D008875:Middle Aged
D001786:Blood Glucose; D007328:Insulin; D007330:Insulin Antibodies; D005934:Glucagon
Glukosetoleranz und Insulinsekretion in Beziehung zum Lebensalter beimTyp-II-Diabetes--Beitrag zur Pathogenese des Typ-II-Diabetes mellitus.