Antimutagenic effects of germanium oxide on Trp-P-2-induced frameshift mutations in Salmonella typhimurium TA98 and TA1538.
A germanium compound, germanium oxide (GeO2) behaved as a potent antimutagen on frameshift-type reverse mutations induced by 3-amino-1-methyl-5H-pyrido[4,3-b]indole (Trp-P-2) in strains of Salmonella typhimurium TA98 and TA1538 with and without a plasmid pKM101, respectively. This metal antimutagen seems to work independently of the plasmid, a promotive factor in chemically induced mutagenesis through error-prone DNA repair.
D000818:Animals; D001711:Biotransformation; D002243:Carbolines / Q000633:toxicity*; D005857:Germanium / Q000494:pharmacology*; D007211:Indoles / Q000633:toxicity*; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects
D002243:Carbolines; D007211:Indoles; D009153:Mutagens; D005857:Germanium; C040516:germanium oxide; C019133:3-amino-1-methyl-5H-pyrido(4,3-b)indole