title: Collagen production and types in fibrous capsules around breast implants.
abstract: This study demonstrates that increased collagen production but not an altered ratio of type III:I collagen is associated with breast capsular contracture. From these findings and previous data, therefore, it appears that capsular contracture is associated with increased foreign-body response biochemically as well as histologically. Further studies are required to directly assess the reasons for contraction around some implants and not others; however, it appears that control of capsular contracture may be achieved by controlling biochemical as well as cellular events associated with contraction. Such studies remain to be done.
mesh_terms: D000328:Adult; D001940:Breast / Q000378:metabolism / Q000473:pathology* / Q000601:surgery; D002921:Cicatrix / Q000473:pathology; D003094:Collagen / Q000096:biosynthesis* / Q000145:classification; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005549:Foreign-Body Reaction / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D019736:Prostheses and Implants; D012867:Skin / Q000473:pathology
chemical_list: D003094:Collagen