title: A double-blind comparison of nefopam and placebo used as a premedication in children.
abstract: Forty-two children received either nefopam or a matched placebo as oral premedication in a double-blind trial. Nefopam performed no better than placebo as a premedication and as postoperative analgesic. Its use is not recommended in paediatric anaesthesia because of a significantly high incidence of vomiting on awakening.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D009340:Nefopam / Q000009:adverse effects; D010079:Oxazocines / Q000009:adverse effects; D011183:Postoperative Complications; D011229:Preanesthetic Medication / Q000009:adverse effects; D011897:Random Allocation; D014839:Vomiting / Q000139:chemically induced
chemical_list: D010079:Oxazocines; D009340:Nefopam