A comparative study of the bronchospasmolytic effect of tulobuterol and fenoterol in patients suffering from a reversible bronchial obstruction.
The bronchospasmolytic effect of a single oral dose of 2.5 mg tulobuterol was compared with that of 2.5 mg fenoterol in a double-blind study in patients with reversible bronchial obstruction. The effects of tulobuterol were more quickly observed and were, in general, more advantageous. However, only at 120 min after administration of the drugs the difference showed a statistical trend (p less than 0.1). Unwanted effects from both drugs were comparable.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D001986:Bronchial Spasm / Q000188:drug therapy* / Q000503:physiopathology; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D005280:Fenoterol / Q000009:adverse effects / Q000627:therapeutic use*; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D011674:Pulse / Q000187:drug effects; D013726:Terbutaline / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
D004983:Ethanolamines; D005280:Fenoterol; C010809:tulobuterol; D013726:Terbutaline