Defective bursa regeneration after irradiation of young thymectomized chickens.
The ability of the bursa of Fabricius to regenerate after gamma-irradiation and bone marrow reconstitution was examined in chickens thymectomized (TX) immediately after hatching. Irradiation (2 X 500 R) 3 weeks after hatching was followed by impaired bursa regeneration, as judged both by bursa/body weight ratios and by bursa follicle development 3-6 weeks later in TX as compared to control birds. Germinal center formation in the spleen was deficient, and immune responses to sheep erythrocytes (SRBC) and B. abortus (BA) were moderately reduced in the TX as compared to control birds irradiated at 3 weeks but not in TX birds irradiated at 5 weeks of age.
D000818:Animals; D016026:Bone Marrow Transplantation; D002060:Bursa of Fabricius / Q000473:pathology / Q000503:physiopathology* / Q000528:radiation effects; D002645:Chickens; D009929:Organ Size; D011828:Radiation Chimera; D012038:Regeneration / Q000528:radiation effects; D013934:Thymectomy; D013950:Thymus Gland / Q000276:immunology / Q000502:physiology