Autoantibodies to a 64-kilodalton islet cell protein precede the onset of spontaneous diabetes in the BB rat.
Spontaneous insulin-dependent diabetes mellitus (IDDM) in the BB rat is associated with the presence of antibodies to a 64-kilodalton rat islet cell protein. These protein antibodies appeared in young animals and remained for as long as 8 weeks before the clinical onset of IDDM. Antibodies to a 64-kilodalton human islet cell protein were found to be associated with human IDDM. Detection of the antibodies may therefore be used to predict an early immune reaction against pancreatic B cells.
D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D003921:Diabetes Mellitus, Experimental / Q000276:immunology*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains
D001323:Autoantibodies