Enolase distribution in human brain tumors, retinoblastomas and pituitary adenomas.
The cellular localization of alpha-, beta- and gamma-subunits of enolase isoenzyme was studied immunohistochemically in various human brain tumors, retinoblastomas and pituitary adenomas (total, 91 cases). The alpha-subunit was found in almost all brain tumors except in medulloblastoma cases. A case of medullomyoblastoma contained beta-subunit-positive myoblastic cells, which was also positive for human myoglobin. The gamma-subunit was frequently observed in medulloblastomas, retinoblastomas and pituitary adenomas. However, gamma-subunit was also present in some non-neuronal brain tumors such as astrocytomas and oligodendrogliomas. Enzyme immunoassay technique also confirmed the presence of gamma-subunit in a medulloblastoma and two retinoblastomas.
D000236:Adenoma / Q000201:enzymology*; D001932:Brain Neoplasms / Q000201:enzymology*; D002528:Cerebellar Neoplasms / Q000201:enzymology; D005134:Eye Neoplasms / Q000201:enzymology*; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007527:Isoenzymes / Q000378:metabolism*; D008527:Medulloblastoma / Q000201:enzymology; D010751:Phosphopyruvate Hydratase / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000201:enzymology*; D012175:Retinoblastoma / Q000201:enzymology*
D007527:Isoenzymes; D010751:Phosphopyruvate Hydratase