Studies on xylitol-induced insulin secretion in vitro.
A comparative study on the insulinotropic effect of xylitol and glucose was undertaken using isolated rat islets of Langerhans. Xylitol and glucose showed equal insulinotropic effects when compared at equivalent dose levels. Xylitol-induced insulin release was not inhibited by either mannoheptulose or 2-deoxy-D-glucose whereas glucose-induced insulin release was significantly inhibited. Glucagon, caffeine and cyclic-AMP enhanced the insulinotropic effect of glucose and leucine significantly, but insulin release in response to xylitol was not affected. Arginine did not potentiate the insulin releasing effect of xylitol though leucine showed an additive effect. These findings suggest that the mode of action of xylitol may be different from that of glucose.
D000818:Animals; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014993:Xylitol / Q000378:metabolism / Q000494:pharmacology*
D007328:Insulin; D005947:Glucose; D014993:Xylitol