[Gastric secretion after major resection of the pancreas, with special reference to gut hormones and gastric acid secretion in Sandmeyer's diabetes].
The influences of major pancreas resection upon gastric acid secretion and gut hormones were studied in dogs with Heidenhain pouches. Immediately after resection of 90% or more of the entire pancreas, diabetes occurred with an abrupt decrease in insulin and glucagon secretion, and a marked increase in gastric acid output, though gastrin secretion decreased and secretin secretion increased, as after total pancreatectomy. Six weeks or more after resection of 70 to 90% of the entire pancreas, so-called Sandmeyer's diabetes occurred as a consequence of a decrease in insulin secretion and an increase in glucagon secretion from the remnant pancreas. Gastric acid output decreased markedly, and gastrin secretion also decreased. After resection of less than 70% of the entire pancreas, diabetes did not occur during 66 weeks of the longest observation period after surgery. Gastric acid output, secretion of gastrin and secretin did not change after surgery. These results suggest that gastric hypersecretion occurs after total pancreatectomy and resection of 90% or more of the entire pancreas, and it is related to pancreatic exocrine insufficiency and that gastric hyposecretion occurs after resection of 70 to 90% of the entire pancreas, and it may be related to hypersecretion of glucagon and somatostatin.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000209:etiology / Q000378:metabolism*; D004285:Dogs; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism*; D005934:Glucagon / Q000097:blood; D007328:Insulin / Q000097:blood; D010180:Pancreatectomy; D011184:Postoperative Period; D012633:Secretin / Q000378:metabolism*
D005755:Gastrins; D007328:Insulin; D012633:Secretin; D005934:Glucagon