The effect of lentil lectin treatment on the survival of rat skin allografts in strain combinations with different genetic disparity.
The effect of lentil lectin on the survival of skin allografts was investigated in six rat strain combinations with different genetic disparities between the donors and recipients. LCA was administered i.p. (50 mg/kg) to the recipients daily, starting with the day of transplantation (day 0) until graft rejection, except that the doses on days 1, 3, 5, 7, and 9 were given i.v. (25 mg/kg). LCA treatment was more efficient in prolongation of skin graft survival time in congenic strain combinations differing in multiple non-RT1 antigens (RT1-compatible) than in those involving RT1 disparities.
D000818:Animals; D005260:Female; D014644:Genetic Variation; D006085:Graft Survival / Q000187:drug effects*; D006649:Histocompatibility Antigens / Q000235:genetics; D007108:Immune Tolerance / Q000187:drug effects; D007519:Isoantigens / Q000235:genetics; D037102:Lectins / Q000494:pharmacology*; D008297:Male; D037121:Plant Lectins; D051381:Rats; D011914:Rats, Inbred BN / Q000235:genetics / Q000276:immunology; D011917:Rats, Inbred Lew / Q000235:genetics / Q000276:immunology; D011919:Rats, Inbred Strains / Q000235:genetics* / Q000276:immunology; D012867:Skin / Q000187:drug effects; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D006649:Histocompatibility Antigens; D007519:Isoantigens; D037102:Lectins; D037121:Plant Lectins; C033619:lentil lectin