[Sensitivity to insulin in type I diabetes. Preliminary report].
In vivo sensitivity to insulin was assessed by the euglycaemic insulin clamp technique in 5 type I diabetic subjects without residual insulin secretion and in 5 non-diabetic control subjects. Insulin was infused at increasing rates of 0.5, 1.0, 2.0 and 5.0 mU/kg/min in 4 periods of 2 hours. The diabetic subjects were resistant to insulin during the 1st and 2nd insulin infusion periods corresponding to the rates of 0.5 and 1.0 mU/kg/min, when compared to the non-diabetic subjects. However, glucose disposal rates were similar in the diabetic and control subjects at the 2 higher insulin infusion rates (2.0 and 5.0 mU/kg/min). Thus insulin resistance in type I diabetes is dependent on insulin concentration.
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007263:Infusions, Parenteral; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D007333:Insulin Resistance; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D007328:Insulin
Sensibilité à l'insuline dans le diabète de type I. Rapport préliminaire.