Immunologic injury to vascular endothelial cells: effects on release of prostacyclin.
Prostacyclin is released from cultured and ex vivo bovine vascular endothelium following sublethal immunologic injury by a heterologous antibody to endothelial cells developed in rabbits. This release was dependent on calcium and complement and was not enhanced by the presence of platelets. Prostacyclin release was diminished 1-2 hr after the injury, but recovered fully following reculture of the endothelial cells for 72 hr.
D000818:Animals; D000906:Antibodies / Q000502:physiology; D001011:Aorta; D001792:Blood Platelets / Q000502:physiology; D002417:Cattle; D002478:Cells, Cultured; D003165:Complement System Proteins / Q000502:physiology; D004727:Endothelium / Q000276:immunology / Q000378:metabolism / Q000473:pathology; D011464:Epoprostenol / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000276:immunology* / Q000293:injuries / Q000378:metabolism; D011460:Prostaglandins F / Q000378:metabolism; D011651:Pulmonary Artery; D011817:Rabbits
D000906:Antibodies; D011460:Prostaglandins F; D003165:Complement System Proteins; D011464:Epoprostenol; C100006:prostaglandin F1