Effects of ethyl-CPIB (clofibrate) on tissue lipoprotein lipase and plasma post-heparin lipolytic activity in rats.
The role of LPL in reducing the serum triacylglycerol concentration was investigated in rats fed a high sucrose diet containing 0.25% (w/w) ethyl-CPIB. Compared with sucrose-fed controls, drug treatment resulted in a fall in adipose tissue LPL activity and a rise in enzyme activity in thigh and heart muscle. Serum post-heparin lipoprotein lipase activity after a high dose of heparin was lower in ethyl-CPIB-treated rats than controls, but after a low dose of heparin the values were similar. The amount of LPL activator was decreased by the drug. Thus, the low serum triacylglycerol concentration observed in the ethyl-CPIB-treated rats cannot be explained by changes in functional LPL activity. The plasma triacylglycerol-lowering effect of the drug could be explained by the observed decrease in triacylglyerol output by the liver.
D000273:Adipose Tissue / Q000201:enzymology; D000818:Animals; D002994:Clofibrate / Q000494:pharmacology*; D004040:Dietary Carbohydrates / Q000494:pharmacology; D006493:Heparin / Q000494:pharmacology; D007328:Insulin / Q000097:blood; D008066:Lipolysis / Q000187:drug effects*; D008071:Lipoprotein Lipase / Q000097:blood / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D013395:Sucrose / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood* / Q000378:metabolism
D004040:Dietary Carbohydrates; D007328:Insulin; D014280:Triglycerides; D013395:Sucrose; D006493:Heparin; D008071:Lipoprotein Lipase; D002994:Clofibrate