title: Evolutionary divergence of genes for ornithine and aspartate carbamoyl-transferases--complete sequence and mode of regulation of the Escherichia coli argF gene; comparison of argF with argI and pyrB.
abstract: The complete nucleotide sequence of argF is presented, together with that of an operator-constitutive mutant. ArgF is compared with the other gene coding for ornithine carbamoyltransferase (OTCase) in E. coli K-12, argI, and with pyrB, encoding the catalytic monomer of aspartate carbamoyltransferase (ATCase). ArgF and argI appear very closely related having emerged from a relatively recent ancestor gene. The relationship between OTCase and ATCase appears more distant. Nevertheless, the homology observed between the two proteins (mainly in the polar domain) suggests a common origin.
mesh_terms: D001120:Arginine / Q000235:genetics; D001221:Aspartate Carbamoyltransferase / Q000235:genetics*; D001483:Base Sequence; D005075:Biological Evolution; D003062:Codon; D004926:Escherichia coli / Q000235:genetics*; D005786:Gene Expression Regulation; D005796:Genes; D005798:Genes, Bacterial; D009154:Mutation; D009876:Operon; D009954:Ornithine Carbamoyltransferase / Q000235:genetics*; D011487:Protein Conformation
chemical_list: D003062:Codon; D001120:Arginine; D001221:Aspartate Carbamoyltransferase; D009954:Ornithine Carbamoyltransferase