Analysis of an inhibin preparation reveals apparent identity between a peptide with inhibin-like activity and a sperm-coating antigen.
The amino acid sequence of a large form of inhibin-like peptide in human seminal plasma was determined, and compared with structures reported for similar inhibin preparations and a seminal plasma globulin. The data confirm and correlate previous reports on this form of inhibin-like peptide. The structural comparisons further suggest that the peptide is closely similar to or possibly identical to a sperm-coating antigen reported to be synthesized from prostatic epithelium. This may correlate with non-gonadal origins of inhibin-like material and will help to elucidate the biological roles of inhibin(s).
D000595:Amino Acid Sequence; D000954:Antigens, Surface; D003488:Cyanogen Bromide; D003546:Cysteine Endopeptidases; D010450:Endopeptidases; D006801:Humans; D007265:Inhibins; D008297:Male; D010446:Peptide Fragments; D012661:Semen / Q000032:analysis*; D013094:Spermatozoa / Q000276:immunology*; D014357:Trypsin
D000954:Antigens, Surface; D010446:Peptide Fragments; D007265:Inhibins; D010450:Endopeptidases; D014357:Trypsin; D003546:Cysteine Endopeptidases; C019913:clostripain; C042769:Staphylococcus aureus glutamic protease; D003488:Cyanogen Bromide