Glucose, insulin and C-peptide kinetics during continuous ambulatory peritoneal dialysis.
The insulin and C-peptide kinetics due to glucose (50 g), given intraperitoneally or enterally has been compared in five non-diabetic patients on continuous ambulatory peritoneal dialysis (CAPD). The fasting C-peptide concentrations were three to ten times the normal values whereas the fasting plasma insulin concentrations were within normal limits. After intraperitoneal glucose administration a more marked hyperglycaemia (p less than 0.05) and a more long lasting hyperinsulinaemia (p less than 0.05) was found than after the enteral glucose load. The relative change in plasma C-peptide was slower and less pronounced in both experiments. C-peptide concentration in plasma did not differ significantly between the two experiments. Estimated total body clearance (Kt) for insulin was higher than for C-peptide (p less than 0.01), but dialysis clearance (Kd) for C-peptide was higher than for insulin in both experiments (p less than 0.01).
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood*; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D007328:Insulin / Q000097:blood*; D007700:Kinetics; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010531:Peritoneal Dialysis, Continuous Ambulatory
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D005947:Glucose