Homogeneous magnetic fields influence pancreatic islet function in vitro.
Pancreatic islets were isolated from newborn rats and exposed to homogeneous magnetic fields for 48 hours. Under these conditions insulin release, measured at low (5.6 mM) and high (16.7 mM) glucose concentrations, was significant and dose-dependent only at low glucose concentrations. High glucose and aminophylline (10 mM) inhibited insulin release. Thus, in the absence of stimulatory glucose concentrations, low-intensity magnetic fields (1 to 10 Gauss) significantly influence insulin discharge from rat islets in vitro.
D000818:Animals; D000831:Animals, Newborn; D002465:Cell Movement; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000166:cytology / Q000378:metabolism / Q000502:physiology*; D008280:Magnetics; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin