title: Mechanisms of elevated blood pressure in human essential hypertension.
abstract: This review of the mechanisms of elevation of blood pressure in human essential hypertension first focuses on individual mechanisms and their interrelations. The authors then try to identify those forms of essential hypertension in which the major determinants are known. When the most significant processes associated with elevated blood pressure in individual patients are understood, a rational approach to therapy can be undertaken even though the ultimate cause of the disorder is not understood.
mesh_terms: D000328:Adult; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004039:Diet, Sodium-Restricted; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000378:metabolism / Q000628:therapy; D007668:Kidney / Q000378:metabolism; D008297:Male; D051381:Rats; D012084:Renin-Angiotensin System; D012964:Sodium / Q000009:adverse effects* / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000378:metabolism
chemical_list: D012964:Sodium