[Protective properties of Proteus ribosomal vaccine].
The results of the study of the protective properties of Proteus ribosomal vaccine prepared from P. vulgaris museum strain F-30 are presented. The vaccine showed protective effect even in a dose of 0.0001 microgram of protein per mouse; when used in immunization doses of 1 and 10 micrograms of protein per mouse, the vaccine completely protected the animals, ensuring their survival. Experiments aimed at the determination of the maximum protective effect of the vaccine were carried out. The ribosomal vaccine injected in a dose of 1 microgram of protein per mouse protected 50% of mice challenged with 10 LD50; in a dose of 10 micrograms of protein per mouse the vaccine protected 100% of the animals challenged with 3.7 and 10 LD50. Proteus ribosomal vaccine prepared from P. vulgaris museum strain was shown to render protective effect with respect to P. vulgaris and P. mirabilis clinical strains.
D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology* / Q000302:isolation & purification; D001431:Bacteriological Techniques; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D007114:Immunization; D051379:Mice; D011512:Proteus Infections / Q000517:prevention & control; D011513:Proteus mirabilis / Q000276:immunology; D011514:Proteus vulgaris / Q000276:immunology* / Q000302:isolation & purification; D012270:Ribosomes / Q000276:immunology*; D013997:Time Factors
D001428:Bacterial Vaccines
Protektivnye svoĭstva ribosomal'noĭ proteĭnoĭ vaktsiny.