Influence of indomethacin delivered from an intrauterine silastic device on basal levels and synthesizing capability of rat uterus for prostacyclin.
The intrauterine release of indomethacin (approximately 120 micrograms over 23 days) from a unilateral silastic device did not cause any significant reduction in basal levels of PGI2 (determined as 6-keto PGF1 alpha) in the tissue of the IUD horn. However, this tissue was found to have an increased potential for PGI2 synthesis when compared to that of the uterine horn with a plain device. The implications of these findings regarding a possible effect of indomethacin on the myometrium are discussed.
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000818:Animals; D011464:Epoprostenol / Q000096:biosynthesis*; D005260:Female; D007213:Indomethacin / Q000008:administration & dosage*; D007434:Intrauterine Devices; D051381:Rats; D011919:Rats, Inbred Strains; D012826:Silicone Elastomers; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D012826:Silicone Elastomers; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol; D007213:Indomethacin