Oxygen toxicity and other ventilatory complications of treatment of infants with persistent pulmonary hypertension.
While current ventilator therapy has greatly improved the outlook for infants with persistent pulmonary hypertension, it brings with it substantial risk for serious lung injury from oxygen toxicity, barotrauma, and alveolar rupture. This article discusses the mechanisms by which these complications occur and methods by which they can be prevented.
D000818:Animals; D000831:Animals, Newborn; D001469:Barotrauma; D001997:Bronchopulmonary Dysplasia / Q000209:etiology; D002908:Chronic Disease; D006801:Humans; D007231:Infant, Newborn; D008171:Lung Diseases / Q000139:chemically induced / Q000473:pathology; D008478:Mediastinal Emphysema / Q000209:etiology; D010100:Oxygen / Q000633:toxicity*; D010547:Persistent Fetal Circulation Syndrome / Q000628:therapy*; D011026:Pneumopericardium / Q000209:etiology; D011027:Pneumoperitoneum / Q000209:etiology; D011650:Pulmonary Alveoli / Q000293:injuries / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000473:pathology; D012121:Respiration, Artificial / Q000009:adverse effects* / Q000379:methods; D012421:Rupture; D012756:Sheep
D010100:Oxygen