Combined preoperative antibiotic therapy and intraoperative topical povidone-iodine. Reduction of wound sepsis following emergency appendectomy.
Single doses of clindamycin hydrochloride and gentamicin sulfate given preoperatively, combined with intraoperative topical application of povidone-iodine were given to patients with perforated or gangrenous appendicitis. The incidence of wound sepsis was reduced from 36% to 5%; severe infections were reduced from 25% to 0% when compared with a control untreated group of patients. When used alone, povidone-iodine had little effect in these patients. No toxic effects of the antibiotics or antiseptic were recorded nor were any resistant strains of pathogenic organisms grown from cultures.
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D001062:Appendectomy; D001064:Appendicitis / Q000601:surgery; D002981:Clindamycin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D004630:Emergencies; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D007430:Intraoperative Care; D008875:Middle Aged; D011205:Povidone / Q000031:analogs & derivatives*; D011206:Povidone-Iodine / Q000627:therapeutic use*; D011292:Premedication; D013530:Surgical Wound Infection / Q000517:prevention & control*
D005839:Gentamicins; D002981:Clindamycin; D011206:Povidone-Iodine; D011205:Povidone