H-2-linked genes which modify resistance of C57BL/10 mice to subcutaneous infection with Mycobacterium lepraemurium.
Strains of C57BL/10 mice with recombinants within the H-2 complex were used to map the genes which control the mononuclear cell response at the infection site and modify resistance to subcutaneous infection with Mycobacterium lepraemurium. Strains with b in the K-E beta regions of the H-2 complex mounted a more rapid cellular response in the infected footpad and were more resistant than mice with d or k in the K-E beta regions. Significant differences between strains with k in the K-E beta regions appeared to be controlled by a gene in the D region.
D000818:Animals; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics*; D007113:Immunity, Innate; D008285:Major Histocompatibility Complex; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics / Q000276:immunology*; D009164:Mycobacterium Infections / Q000235:genetics / Q000276:immunology* / Q000382:microbiology; D009167:Mycobacterium lepraemurium
D006183:H-2 Antigens