UM-SCP-1, a new human cell line derived from a prostatic squamous cell carcinoma.
A permanent cell line (UM-SCP-1) has been established from a primary squamous cell carcinoma of the prostate. UM-SCP-1 has been passaged 40 times and has been in culture for 22 months. The doubling time of this aneuploid cell line is approximately 36 hr. In nude mice, UM-SCP-1 produces rapidly growing tumors with distinct histological features of squamous cell carcinoma. UM-SCP-1 cells express pemphigus and pemphigoid antigens and bind antibodies to beta 2 microglobulin and HLA-A,B,C common antigen. Cells of this line are unreactive with anti-A and anti-B blood group typing sera, autologous serum, and monoclonal anti-HLA-DR antibodies.
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000503:physiopathology*; D002455:Cell Division; D002460:Cell Line; D006801:Humans; D007621:Karyotyping; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D011471:Prostatic Neoplasms / Q000473:pathology / Q000503:physiopathology*; D014183:Transplantation, Heterologous; D001613:beta 2-Microglobulin / Q000032:analysis
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D001613:beta 2-Microglobulin