Transformation of fibre types in muscular dystrophies.
In the normal human skeletal muscle, slow and fast forms of troponin I are segregated in type I and type II cells, respectively. Muscle biopsies from different dystrophies showed a large number of intermediate cells that stained with antibodies to both fast and slow troponin I. Intermediate cells of variable size were scattered at random and did not show a motor unit distribution as generally seen in some neuromuscular disorders. The preponderance of a particular cell type depended on the type of dystrophy. Except for dystrophia myotonica, all cases showed presence of small cells that looked like regenerating cells.
D000328:Adult; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D009132:Muscles / Q000294:innervation / Q000378:metabolism / Q000473:pathology*; D009136:Muscular Dystrophies / Q000378:metabolism / Q000473:pathology*; D009223:Myotonic Dystrophy / Q000473:pathology; D009416:Nerve Regeneration; D014336:Troponin / Q000378:metabolism*; D019210:Troponin I
D014336:Troponin; D019210:Troponin I