Some mechanisms of disturbances and recovery of T-lymphocyte migratory properties in irradiated mice.
Migration of 51Cr-labelled T cells from irradiated mice into lymph nodes of syngeneic unirradiated recipients decreased in a dose-dependent fashion. Influx of labelled T cells between 4 and 24 hr after injection (secondary migration) is more radiosensitive than lymph-node migration of T cells in the first 4 hr (primary migration). Treatment of T cells from irradiated mice in vitro with Con A or with trypsin does not enhance radiation-induced alteration of their migratory properties, but irradiation enhances the effects of Con A and trypsin on T-cell migration. Recovery of primary migration of irradiated T cells is completed 3 months after irradiation; it is probably caused by T-cell renewal. The defect of T-cell secondary migration is more stable: it remains 6 months after irradiation in a dose of 4 Gy. Post-irradiation defects of the T-cell differentiation process as a cause of long-lasting alteration of T-cell secondary migration are discussed.
D000818:Animals; D002462:Cell Membrane / Q000528:radiation effects; D002465:Cell Movement / Q000528:radiation effects; D002478:Cells, Cultured; D002860:Chromium Radioisotopes; D008198:Lymph Nodes / Q000276:immunology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D013934:Thymectomy; D013997:Time Factors; D014916:Whole-Body Irradiation
D002860:Chromium Radioisotopes