title: Depressive effects of morphine and of an enkephalinase inhibitor on responses of ventro-basal thalamic neurones to noxious stimuli.
abstract: It has been shown that the responses of VB thalamic neurones to noxious mechanical and thermal stimuli are strongly depressed by low doses of Morphine (0,03; 0,1; 1 mg/kg i.v.) and to a lesser extent by ES 52 (a highly potent Thiorphan derivative) injected at higher doses (5; 10 mg/kg i.v). This last effect was less easily reversed by Naloxone than was the depressive effect of Morphine. Moreover, ES 52 can facilitate activity of some thalamic neurones induced by non-noxious mechanical stimuli.
mesh_terms: D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D000818:Animals; D009020:Morphine / Q000494:pharmacology*; D015260:Neprilysin; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D011480:Protease Inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D013788:Thalamus / Q000502:physiology*; D015244:Thiorphan / Q000031:analogs & derivatives*; D008625:Tiopronin / Q000031:analogs & derivatives / Q000494:pharmacology*
chemical_list: D000603:Amino Acids, Sulfur; D011480:Protease Inhibitors; D009020:Morphine; C040246:ES 52; D015244:Thiorphan; D008625:Tiopronin; D015260:Neprilysin