[Inhibition of the insulin receptor activity of fat cell plasma membranes in rats with hyperadrenalinemia].
Insulin receptor interaction was examined in fatty plasma membranes of rats given adrenaline hydrochloride for 6 days in a dose producing a 10-20-fold increase in adrenaline excretion. A significant reduction in specific 125I-insulin binding was discovered in the presence of the lowered concentration of blood plasma immunoreactive insulin versus the control. Analysis made according to Skatchard, Meyts and Roth indicates that the reduced specific binding of 125I-insulin is accounted for by the decreased affinity and number of insulin binding sites and, to a less degree, by the increased negative cooperativity.
D000273:Adipose Tissue / Q000187:drug effects*; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000097:blood* / Q000494:pharmacology / Q000652:urine; D007328:Insulin / Q000097:blood*; D007330:Insulin Antibodies / Q000032:analysis; D008297:Male; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011972:Receptor, Insulin / Q000187:drug effects*; D013997:Time Factors
D007328:Insulin; D007330:Insulin Antibodies; D011972:Receptor, Insulin; D004837:Epinephrine
Ugnetenie aktivnosti insulinovykh retseptorov plazmaticheskikh membran zhirovykh kletok u krys pri giperadrenalinemii.