Adipose tissue and cholesterol metabolism.
Adipose tissue in man is a major site for cholesterol storage. In obesity over half of total body cholesterol may reside within this tissue; however, relatively little attention has been directed toward understanding the cholesterol metabolism and its relationship to whole body cholesterol homeostasis in this tissue. In this review the factors which influence cholesterol storage are discussed, with particular emphasis on the effects of diet and drug treatment in both animals and man. The uptake, synthesis, and mobilization of adipose tissue cholesterol appears to be mediated and/or regulated, as in other tissues, by the plasma lipoproteins, and these processes are examined with regard to both normal and pathologic states.
D000273:Adipose Tissue / Q000378:metabolism*; D000367:Age Factors; D000818:Animals; D001053:Apolipoproteins / Q000378:metabolism; D001835:Body Weight; D002318:Cardiovascular Diseases / Q000378:metabolism; D002784:Cholesterol / Q000096:biosynthesis / Q000378:metabolism*; D004041:Dietary Fats / Q000378:metabolism; D005224:Fats, Unsaturated / Q000378:metabolism; D006801:Humans; D006937:Hypercholesterolemia / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000494:pharmacology; D008074:Lipoproteins / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D002787:Sterol Esterase / Q000378:metabolism
D001053:Apolipoproteins; D004041:Dietary Fats; D005224:Fats, Unsaturated; D000960:Hypolipidemic Agents; D008074:Lipoproteins; D002784:Cholesterol; D002787:Sterol Esterase