Depressive effects of morphine and of an enkephalinase inhibitor on responses of ventro-basal thalamic neurones to noxious stimuli.
It has been shown that the responses of VB thalamic neurones to noxious mechanical and thermal stimuli are strongly depressed by low doses of Morphine (0,03; 0,1; 1 mg/kg i.v.) and to a lesser extent by ES 52 (a highly potent Thiorphan derivative) injected at higher doses (5; 10 mg/kg i.v). This last effect was less easily reversed by Naloxone than was the depressive effect of Morphine. Moreover, ES 52 can facilitate activity of some thalamic neurones induced by non-noxious mechanical stimuli.
D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D000818:Animals; D009020:Morphine / Q000494:pharmacology*; D015260:Neprilysin; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009619:Nociceptors / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D011480:Protease Inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D013788:Thalamus / Q000502:physiology*; D015244:Thiorphan / Q000031:analogs & derivatives*; D008625:Tiopronin / Q000031:analogs & derivatives / Q000494:pharmacology*
D000603:Amino Acids, Sulfur; D011480:Protease Inhibitors; D009020:Morphine; C040246:ES 52; D015244:Thiorphan; D008625:Tiopronin; D015260:Neprilysin