Successful pregnancy with sickle cell disease and renal transplantation.
Renal transplantation has been very effective in the treatment of end-stage renal disease. Over 750 cases of successful pregnancies in these patients have been reported, and only 15 patients with sickle cell disease (homozygous hemoglobin S) have had renal allografts. The present study documents the first case of a successful pregnancy in a patient with sickle cell disease and renal transplantation. The combined complications increase the risks in view of the susceptibility of certain vital organs in pregnancy. Careful multidisciplinary management enhances successful outcome.
D000328:Adult; D000755:Anemia, Sickle Cell / Q000503:physiopathology / Q000628:therapy*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000503:physiopathology / Q000628:therapy*