Contrast agent induced thrombophlebitis following leg phlebography: iopamidol versus meglumine iothalamate.
A comparison was made of the incidence of venous thrombophlebitis resulting from the use of a high-osmolality contrast medium (Conray 60%, meglumine iothalamate), and a low-osmolality contrast medium (Niopam 61%, iopamidol). In 20 patients Conray was injected into one leg and Niopam into the other. The incidence of thrombophlebitis was then determined using the iodine-125 fibrinogen uptake test in a prospective, randomised, double-blind study. There was significantly less thrombophlebitis with Niopam than with Conray and it is concluded that Niopam is a safer contrast medium for phlebography.
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003287:Contrast Media / Q000009:adverse effects*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007479:Iopamidol; D007482:Iothalamate Meglumine / Q000009:adverse effects*; D007483:Iothalamic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D010690:Phlebography / Q000009:adverse effects; D013924:Thrombophlebitis / Q000139:chemically induced*
D003287:Contrast Media; D007483:Iothalamic Acid; D007479:Iopamidol; D007482:Iothalamate Meglumine