[Ornid but not atropine abolishes the insulin receptor reaction of fat and liver plasma membranes to fasting and hyperinsulinemia].
In rats, atropine and saline did not affect the response of insulin receptors increased by fasting but decreased it under condition of hyperinsulinemia in fat and hepatic plasma membranes Ornid abolished the response of the membrane insulin receptors both in fasting and hyperinsulinemia. The data obtained confirm the participation of the sympathetic system in the insulin receptors regulation.
D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001949:Bretylium Compounds / Q000494:pharmacology*; D001950:Bretylium Tosylate / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D005215:Fasting; D006946:Hyperinsulinism / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011972:Receptor, Insulin / Q000187:drug effects* / Q000378:metabolism; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology; D013565:Sympatholytics / Q000494:pharmacology*
D001949:Bretylium Compounds; D007328:Insulin; D013565:Sympatholytics; D001950:Bretylium Tosylate; D001285:Atropine; D011972:Receptor, Insulin
Ornid, no ne atropin, snimaet reaktsiiu insulinovykh retseptorov zhirovykh i pechenochnykh plazmaticheskikh membran na golodanie i giperinsulinemiiu.