Thymocyte activating factor(s) in human gingival fluids.
Human gingival fluid contains a low-molecular-weight factor (10,000 to 25,000) which enhances the proliferation of murine thymocytes in the presence of suboptimal doses of mitogen. Although the gingival fluid has no Interleukin 2 (T cell growth factor) activity, as indicated by its inability to induce proliferation of an IL 2 dependent lymphocytic cell line, it is directly mitogenic for dermal fibroblasts. These studies suggest that the thymocyte and fibroblast growth-promoting properties of human gingival fluid may have important functions in regulating inflammatory responses in the human periodontal tissues.
D000818:Animals; D002634:Chemotaxis, Leukocyte; D004847:Epithelial Cells; D005881:Gingiva / Q000166:cytology; D005883:Gingival Crevicular Fluid / Q000276:immunology* / Q000378:metabolism; D005891:Gingivitis / Q000276:immunology*; D006801:Humans; D007375:Interleukin-1 / Q000302:isolation & purification / Q000502:physiology*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D007375:Interleukin-1