title: Cimetidine for stress-ulcer prophylaxis.
abstract: Although cimetidine is more effective than a placebo for the prophylaxis of stress-induced ulcers, it has no advantage over titrated antacid dosing. Several comparative studies even suggest that combining cimetidine with antacid is no more effective than use of full-dose antacid. Therefore, we recommend prophylactic use of cimetidine only when very large dosages of antacid are required, in order to minimize acid-base disturbances.
mesh_terms: D000863:Antacids / Q000009:adverse effects / Q000627:therapeutic use; D002927:Cimetidine / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D010437:Peptic Ulcer / Q000503:physiopathology / Q000517:prevention & control*; D011897:Random Allocation; D013312:Stress, Physiological / Q000503:physiopathology
chemical_list: D000863:Antacids; D002927:Cimetidine