title: Injury to cultured endothelial cells from human umbilical vein by linoleic acid hydroperoxide.
abstract: The effect of linoleic acid hydroperoxide on cultured endothelial cells from human umbilical vein was examined morphologically. Incubation of the cells with a low concentration (0.5 nmol/ml) of linoleic acid hydroperoxide for 3 h caused a slight decrease in electron density of the mitochondrial matrix. Upon an increase of the concentration to 1.0 nmol/ml, the damage became more pronounced, and enlargement and dilatation of the rough-surfaced endoplasmic reticulum were observed. At higher concentrations (5 and 7.5 nmol/ml), dilatation of the rough-surfaced endoplasmic reticulum became further pronounced, and many vacuoles were observed in the cells.
mesh_terms: D002478:Cells, Cultured; D004727:Endothelium / Q000166:cytology / Q000187:drug effects; D005455:Fluorescent Antibody Technique; D006801:Humans; D007231:Infant, Newborn; D008041:Linoleic Acids / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000494:pharmacology*; D008854:Microscopy, Electron; D013997:Time Factors; D014471:Umbilical Veins / Q000166:cytology* / Q000187:drug effects
chemical_list: D008041:Linoleic Acids; D008054:Lipid Peroxides; C008285:linoleic acid hydroperoxide