Malakoplakia mimicking carcinoma metastatic to lung.
Malakoplakia is a rare inflammatory disorder which infrequently involves sites outside of the lower genitourinary or gastrointestinal tract. We report a case of malakoplakia in which the patient presented with a left renal mass and bilateral pulmonary nodules suggestive of metastatic renal carcinoma. Postmortem cultures of the lesions grew E. coli; macrophages at both sites contained gram-negative bacilli and numerous Michaelis-Gutmann bodies. X-ray spectroscopic analysis of the bodies showed wide variation in calcium, phosphorus, and iron content, suggesting that Michaelis-Gutmann bodies were formed in part by the deposition of amorphous salts.
D003937:Diagnosis, Differential; D004927:Escherichia coli Infections / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000473:pathology*; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000473:pathology*; D008171:Lung Diseases / Q000175:diagnosis / Q000473:pathology*; D008175:Lung Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000556:secondary*; D008287:Malacoplakia / Q000175:diagnosis / Q000382:microbiology / Q000473:pathology*; D008875:Middle Aged