Allogeneic bone marrow transplantation in a patient with acute myeloid leukemia secondary to Hodgkin's disease.
A patient with Hodgkin's disease entered complete clinical remission by combination radiochemotherapy. He developed dyshematopoiesis 1.5 years later and an overt acute nonlymphocytic leukemia 3 years after diagnosis. A complete remission was achieved following 2 courses of intensive polychemotherapy. Four months later, while still in remission, he underwent an allogeneic bone marrow transplantation (BMT) from an HLA-identical sister. Mild chronic graft versus host disease of the skin occurred 3 months after BMT, and now the patient has been in complete remission of leukemia for over 2 years. This appears to be a unique case of prolonged remission of a leukemia secondary to an intensively treated Hodgkin's disease.
D000208:Acute Disease; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy / Q000009:adverse effects; D006689:Hodgkin Disease / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007951:Leukemia, Myeloid / Q000209:etiology / Q000628:therapy*; D008297:Male; D011379:Prognosis; D012871:Skin Diseases / Q000209:etiology; D014184:Transplantation, Homologous / Q000009:adverse effects