[Protective activity of a cell-free Klebsiella vaccine in relation to different Klebsiella pneumoniae serovars].
The capacity of dried Klebsiella cell-free vaccine, obtained from strain No. 204 by the disintegration of microbial cells with hydroxylamine, for protecting mice from Klebsiella septic infection caused by the homologous serovar and 9 heterologous serovars of K. pneumoniae was studied. The newly developed preparation was found capable of stimulating immunity not only to the homologous K. pneumoniae serovar, but also to other K. pneumoniae heterologous serovars: K1, K9, K11, K16, K20, K61. The protective capacity of the preparation with respect to these serovars was not inferior to that of the vaccines prepared by the same method from the corresponding homologous strains. The capacity of the vaccine to protect mice from Klebsiella sepsis was manifested irrespective of the virulence of the strains used for challenge.
D000818:Animals; D001428:Bacterial Vaccines / Q000276:immunology / Q000627:therapeutic use*; D002458:Cell Fractionation; D004353:Drug Evaluation, Preclinical; D007110:Immunity, Active; D007710:Klebsiella Infections / Q000276:immunology / Q000517:prevention & control; D007711:Klebsiella pneumoniae / Q000145:classification / Q000276:immunology* / Q000472:pathogenicity; D007928:Lethal Dose 50; D051379:Mice; D012703:Serotyping; D014774:Virulence
D001428:Bacterial Vaccines
Protektivnaia aktivnost' beskletochnoĭ klebsielleznoĭ vaktsiny v otnoshenii razlichnykh serovarov Klebsiella pneumoniae.