Selective effects of secretagogues on insulin secretion: a mathematical model.
A mathematical model of the secretion of insulin from pancreatic islets of Langerhans is proposed. Previously proposed mathematical models of insulin secretion have dealt solely with glucose-stimulated release, and not with the more complex patterns of secretion (such as "off-responses") in response to other secretagogues or combinations of secretagogues. We conclude that an off-response is consistent with a compartmental model; and the facilitating effect of a constant concentration of glucose on leucine-stimulated insulin secretion is consistent with a selective effect of glucose on a single compartment of the model.
D000818:Animals; D003201:Computers; D004357:Drug Synergism; D005947:Glucose / Q000494:pharmacology; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007930:Leucine / Q000494:pharmacology; D008433:Mathematics; D008954:Models, Biological; D010477:Perfusion; D051381:Rats; D013997:Time Factors
D007328:Insulin; D007930:Leucine; D005947:Glucose