title: Distribution of T-cell subsets as defined by monoclonal antibodies in skin lesions of psoriasis vulgaris.
abstract: Cryostat tissue sections from skin lesions of 16 patients suffering from chronic stationary psoriasis vulgaris were assayed for the presence of distinct T-cell subpopulations with monoclonal antibodies. Using two pan-T surface markers (M-T 4-11 and Lyt 3) the total number of infiltrating T-cells was measured. This cell population was further dissected into Leu 3a (helper/inducer) and M-T 8-11 (cytotoxic/suppressor) positive subsets. Percentages of T-cell subpopulations were within the ranges found in healthy peripheral blood and were thus regarded as normal.
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D011565:Psoriasis / Q000473:pathology*; D012867:Skin / Q000473:pathology*; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal