Thiazide-induced potassium loss not prevented by beta blockade.
Potassium balance was followed in 12 subjects with hypertension during treatment either with timolol and hydrochlorothiazide or with timolol, hydrochlorothiazide, and amiloride. Subjects treated with the beta-blocker and thiazide developed potassium depletion, which was prevented by concomitant treatment with amiloride. Thiazide augments timolol-induced potassium loss and it is suggested that the renal handling of potassium is changed by other mechanisms. The decrement in potassium loss during concomitant amiloride treatment cannot be explained.
D000450:Aldosterone / Q000097:blood; D000584:Amiloride / Q000494:pharmacology; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects*; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008297:Male; D011188:Potassium / Q000378:metabolism*; D012083:Renin / Q000097:blood; D013999:Timolol / Q000494:pharmacology*
D006852:Hydrochlorothiazide; D000450:Aldosterone; D000584:Amiloride; D013999:Timolol; D012083:Renin; D011188:Potassium