[Changes in HDL subfractions in patients with type I diabetes mellitus before and after metabolic control].
In order to further investigate the behaviour of high density lipoproteins in diabetes mellitus, we studied HDL subclasses, HDL2 and HDL3, in 10 patients with newly detected, untreated insulin-deficient diabetes before starting insulin treatment and after getting a good metabolic control. We used the extractive method of Abell to determine HDL-cholesterol after LDL and VLDL precipitation with polyanions and HDL3-cholesterol after HDL2 precipitation with dextransulphate 15,000 m.w. After insulin therapy, we observed a significant increase in HDL-cholesterol and a decrease in serum triglycerides. Only HDL2-cholesterol, but not HDL3-cholesterol, raised; moreover, we found a significant inverse relationship between HDL-cholesterol (and also HDL2-cholesterol) and triglycerides. So, we think that an increase of lipoprotein lipase activity, owing to insulin treatment, could account for our results.
D000293:Adolescent; D000328:Adult; D002648:Child; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D003927:Diet, Diabetic; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008075:Lipoproteins, HDL / Q000097:blood*; D053439:Lipoproteins, HDL2; D053440:Lipoproteins, HDL3; D008297:Male; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D007328:Insulin; D008075:Lipoproteins, HDL; D053439:Lipoproteins, HDL2; D053440:Lipoproteins, HDL3; D014280:Triglycerides; D002784:Cholesterol
Modificazioni delle subfrazioni delle HDL nei pazienti con diabete mellito di tipo I prima e dopo compenso metabolico.