[Effects of L-arginine on glucagon and insulin secretion in patients with acute kidney failure].
In 20 patients with acute renal failure and 11 normal persons the behaviour of the glucagon and insulin secretion was examined after administration of L-arginine. Under standard conditions the glucagon level was significantly higher in the acute renal insufficiency than in the normals. Increased glucagon levels could be stated in the anuric/oliguric as well as in the polyuric phase. After administration of L-arginine in the acute renal failure a significantly higher increase of the glucagon level, but a significantly lower increase of the insulin concentration could be observed than in healthy persons. On account of these findings apart from the endocrinological changes stated also other factors seem to be involved in the pathogenesis of the carbohydrate intolerance in acute renal insufficiency.
D058186:Acute Kidney Injury / Q000503:physiopathology*; D000328:Adult; D001120:Arginine; D005260:Female; D005934:Glucagon / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged
D007328:Insulin; D005934:Glucagon; D001120:Arginine
Der Einfluss von L-Arginin auf die Glukagon- und Insulinsekretion bei Kranken mit akutem Nierenversagen.