title: Suppression by thymidine-requiring mutants of Escherichia coli K-12.
abstract: Thymidine-requiring strains of Escherichia coli isolated by trimethoprim selection often simultaneously acquire the ability to suppress bacteriophage T4 nonsense mutations. Suppression is lost in Thy+ revertants and recombinants, but is sometimes retained in thyA plasmid-bearing transformants. Suppression is restricted in Strr derivatives of the Thy- mutants, indicating that suppression occurs at the level of translation.
mesh_terms: D000483:Alleles; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics* / Q000378:metabolism; D010957:Plasmids / Q000187:drug effects; D011995:Recombination, Genetic / Q000187:drug effects; D013489:Suppression, Genetic / Q000187:drug effects; D013936:Thymidine / Q000235:genetics* / Q000378:metabolism; D014161:Transduction, Genetic / Q000187:drug effects; D014295:Trimethoprim / Q000494:pharmacology
chemical_list: D014295:Trimethoprim; D013936:Thymidine