title: [2 or 4 daily doses of cimetidine in the treatment of gastric ulcer?].
abstract: In a randomized multicentre study of 149 patients with gastric ulcer the effect of 1000 mg cimetidine daily applied in four separate doses was compared to that of 400 mg cimetidine twice a day. In both patient groups similar healing rates were observed. 80.3% and 74.0%, respectively, of the ulcers healed within 6 weeks, and 93.8% and 90.3%, respectively, within 10 weeks. Abdominal pain and antacid consumption decreased under both regimens to a similar degree. Drug safety was good. Lower cost and simplicity in the administration make the b. i. d. regimen of cimetidine preferable to the q. i. d. regimen in the acute treatment of gastric ulcer.
mesh_terms: D000428:Alcohol Drinking; D002927:Cimetidine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D012907:Smoking; D013276:Stomach Ulcer / Q000188:drug therapy*; D013997:Time Factors
chemical_list: D002927:Cimetidine
vernacular_title: Zwei oder vier Tagesdosen Cimetidin zur Behandlung des Ulcus ventriculi?