Effect of single dose of omeprazole on the gastrointestinal peptide response to food.
The gastrointestinal peptide response to food was assessed in 6 healthy subjects following oral administration of 40 mg omeprazole. There was a small but statistically significant increase in basal plasma gastrin six hours after the dose of omeprazole, but the post-prandial plasma gastrin was not significantly increased. There was no significant effect on basal or post-prandial levels of somatostatin, insulin, pancreatic glucagon, enteroglucagon, gastric inhibitory polypeptide, pancreatic polypeptide, motilin, neurotensin, cholecystokinin, secretin, vasoactive intestinal peptide and gastrin-releasing peptide or blood glucose concentration.
D000328:Adult; D001562:Benzimidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005215:Fasting; D005260:Female; D005502:Food; D005749:Gastric Inhibitory Polypeptide / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D006801:Humans; D008297:Male; D009853:Omeprazole; D010191:Pancreatic Polypeptide / Q000378:metabolism; D010919:Placebos; D011897:Random Allocation
D001562:Benzimidazoles; D005755:Gastrins; D005768:Gastrointestinal Hormones; D010919:Placebos; D005749:Gastric Inhibitory Polypeptide; D010191:Pancreatic Polypeptide; D009853:Omeprazole