Study on the anti-hypoxic effect of cinnarizine and its interaction with prostacyclin.
The anti-hypoxic effect of cinnarizine was studied using the following experimental methods: hypobaric and anoxic hypoxia in mice, complete ischemia by decapitation in mice and hemic hypoxia in rats. Papaverine, xanthinol nicotinate and naftidrofuryl were used as reference drugs. In hypobaric and anoxic hypoxia the interaction of cinnarizine with the effect of prostacyclin (PGI2) was investigated. Cinnarizine showed an anti-hypoxic effect in all the methods used. It was more effective in hypobaric and anoxic hypoxia, in incomplete ischemia by decapitation, and less effective in hemic hypoxia. Cinnarizine potentiated the effect of PGI2 shifting the anti-hypoxic dose-response curve of PGI2 to the left. Suggestions as to the possible mechanism of anti-hypoxic action of cinnarizine are made.
D000818:Animals; D001274:Atmospheric Pressure; D001921:Brain / Q000098:blood supply; D002936:Cinnarizine / Q000627:therapeutic use*; D004347:Drug Interactions; D011464:Epoprostenol / Q000627:therapeutic use*; D000860:Hypoxia / Q000188:drug therapy* / Q000503:physiopathology; D007511:Ischemia / Q000503:physiopathology; D008297:Male; D051379:Mice; D009257:Nafronyl / Q000494:pharmacology; D010100:Oxygen / Q000097:blood; D010208:Papaverine / Q000494:pharmacology; D010879:Piperazines / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D014971:Xanthinol Niacinate / Q000494:pharmacology
D010879:Piperazines; D002936:Cinnarizine; D009257:Nafronyl; D014971:Xanthinol Niacinate; D010208:Papaverine; D011464:Epoprostenol; D010100:Oxygen