title: A possible role of intestinal mucin in the pathophysiology of intestinal strangulation obstruction. Consequences of tracing a clinical observation.
abstract: In intestinal strangulation obstruction, the pathophysiology is created by factors deriving from the host as well as from the intestinal flora. This article has focused upon the importance of one host-derived factor, i.e. intestinal mucin. Based upon a long series of in vitro and in vivo experiments utilizing germfree as well as conventional animals, it is concluded that intestinal mucin plays a major role in triggering a pathological plasma proteolysis, thereby interacting with microbial products (as endotoxin) in creating the whole variety of serious symptoms found in this situation.
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000502:physiology; D004195:Disease Models, Animal; D004731:Endotoxins / Q000378:metabolism; D004926:Escherichia coli / Q000472:pathogenicity; D005856:Germ-Free Life; D006023:Glycoproteins / Q000502:physiology; D007082:Ileum / Q000503:physiopathology; D007413:Intestinal Mucosa / Q000382:microbiology; D007415:Intestinal Obstruction / Q000503:physiopathology*; D007419:Intestinal Secretions / Q000502:physiology*; D051379:Mice; D009077:Mucins / Q000502:physiology*; D010587:Phagocytosis; D051381:Rats; D014774:Virulence
chemical_list: D001798:Blood Proteins; D004731:Endotoxins; D006023:Glycoproteins; D009077:Mucins