[Role of DNA damage in the inactivation of Saccharomyces cerevisiae yeasts by 313-nm ultraviolet light].
The relative contribution of respiration photoinhibition and DNA damage in the lethal effect induced by 313 nm ultraviolet light (UV) has been investigated in some strains of the yeast Saccharomyces cerevisiae. It has been shown that cells inactivation is essentially due to photo-induced damage to DNA. By photoreactivation experiments it has been found that dimers of the pyrimidine bases are the main lethal photoproducts induced in the DNA by 313 nm ultraviolet light.
D004271:DNA, Fungal / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D009154:Mutation; D010100:Oxygen / Q000378:metabolism; D011740:Pyrimidine Dimers / Q000528:radiation effects; D012441:Saccharomyces cerevisiae / Q000378:metabolism / Q000528:radiation effects*; D014466:Ultraviolet Rays
D004271:DNA, Fungal; D011740:Pyrimidine Dimers; D010100:Oxygen
Rol' povrezhdeniia DNK v inaktivatsii drozhzheĭ Saccharomyces cerevisiae ul'trafioletovym svetom 313 nm.