[Regulation of lipid oxidation and structural state of the nuclear membrane after the irradiation of tumor-bearing animals].
Changes of antioxidative activity (AOA), lipid composition and microviscosity of different membrane regions in tumor cell nuclei and in the liver of tumor-host with Ehrlich ascite carcinoma (EAC) after irradiation were studied. On the basis of the obtained data the analysis of the control system of lipid oxidation in the membrane was carried out. This control system involves a relationship between AOA changes, lipid composition, their oxidative ability and the nuclear membrane structure. It was shown that after irradiation the control system in the nuclei of tumor cells had the same state as before irradiation and was different from the normal one. The control system in the nuclei of tumor-host liver after irradiation starts to work in a regime which is characteristic of irradiated cells. It was shown that the principle difference in the control system functioning in tumor and tumor-host nuclei disappeared after irradiation.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism* / Q000532:radiotherapy; D002467:Cell Nucleus / Q000378:metabolism* / Q000528:radiation effects / Q000648:ultrastructure; D002784:Cholesterol / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism* / Q000528:radiation effects; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000528:radiation effects / Q000648:ultrastructure; D008560:Membrane Fluidity / Q000528:radiation effects*; D008563:Membrane Lipids / Q000378:metabolism*; D051379:Mice; D010084:Oxidation-Reduction; D013113:Spin Labels; D014783:Viscosity; D014916:Whole-Body Irradiation
D008054:Lipid Peroxides; D008563:Membrane Lipids; D013113:Spin Labels; D002784:Cholesterol
Sistema reguliatsii okisleniia lipidov i strukturnogo sostoianiia iadernoĭ membrany posle deĭstviia oblucheniia na opukholenositeleĭ.