An intravaginal contraceptive device for the delivery of an acrosin and hyaluronidase inhibitor.
A study was begun to develop a contraceptive delivery system that would free the user from precoital or daily administration and utilize a nonhormonal agent as the active ingredient. Testing of such a system in rabbits has led to the development of a device that will release a controlled level of an acrosin and hyaluronidase inhibitor into the vagina. This toroidal device is composed of a core of tetradecyl sodium sulfate (TDSS) incorporated in polyurethane surrounded by a rate-limiting membrane of polyurethane. Such devices had a sustained in vitro TDSS release rate of greater than or equal to 400 micrograms/day for over 30 days. These devices had a complete contraceptive effect in 15 rabbits bred weekly for 4 weeks. The contraceptive effect is due to release of the TDSS into the vagina and the subsequent binding of the TDSS to spermatozoa in the female reproductive tract. TDSS has a very low toxicity profile in the rat, dog, and rabbit.
D000176:Acrosin / Q000037:antagonists & inhibitors*; D000818:Animals; D003271:Contraceptive Agents, Female / Q000008:administration & dosage* / Q000633:toxicity; D004285:Dogs; D004343:Drug Implants; D005233:Fatty Alcohols / Q000008:administration & dosage*; D005260:Female; D006821:Hyaluronoglucosaminidase / Q000037:antagonists & inhibitors*; D008297:Male; D011480:Protease Inhibitors; D011817:Rabbits; D051381:Rats; D011916:Rats, Inbred F344; D012981:Sodium Tetradecyl Sulfate / Q000008:administration & dosage* / Q000633:toxicity; D014622:Vaginal Creams, Foams, and Jellies
D003271:Contraceptive Agents, Female; D004343:Drug Implants; D005233:Fatty Alcohols; D011480:Protease Inhibitors; D014622:Vaginal Creams, Foams, and Jellies; D006821:Hyaluronoglucosaminidase; D000176:Acrosin; D012981:Sodium Tetradecyl Sulfate