Transitions in collagen types during endochondral ossification in human growth cartilage.
Immunohistochemical staining for Types I and II collagen in human growth cartilage showed that cartilage matrix consists of Type II collagen, whereas bone matrix contains Type I collagen. Endochondral ossification began with the deposition of Type I collagen by cells derived from bone marrow on the surface of the eroded cartilage. However, territorial matrix of the last hypertrophic chondrocytes contained both Types I and II collagen, thereby indicating that the degenerating chondrocytes initiate the synthesis of Type I collagen. This matrix, consisting of Types I and II collagen, is then replaced by newly formed osteoid.
D001846:Bone Development; D001857:Bone Matrix / Q000032:analysis*; D002356:Cartilage / Q000032:analysis*; D002675:Child, Preschool; D003094:Collagen / Q000032:analysis* / Q000096:biosynthesis; D005455:Fluorescent Antibody Technique; D006801:Humans; D010012:Osteogenesis
D003094:Collagen