[Antigenicity of trophoblast cells and their significance for placentation and tolerance of human allogenic ova ].
Due to the elucidation of transplantation phenomena of the human allogenic egg, as yet unknown, the antigenicity of each trophoblastic cells was estimated using a cell culture technique introducing the immunofluorescence method. It was studied by means of an immunological model like the fetomaternal incompatibility in the classic AB0-blood system. The in vitro cultured placenta cells (epithelials cells of the chorionic villi, the Langhanscells, the Hofbauercells and also their's daughter cells) were investigated concerning the presence of A- and B-bloodgroup antigens, whereas the direct and indirect immunofluorescence method was introduced. It was confirmed that the chorionic villi epithelial cells are always antigen-less ones. The Langhanscells possess the A- and B-transplantation antigens within their nuclei membranes only. But in Hofbauercells the presence of the antigens could be found within the cell membrane, within the nuclei membrane and also the cytoplasma of the daughter cells. The lack of transplantation antigens in the epithelial layer of the chorionic villi enable as well the placentation and further development of the human allogenic egg.
D000017:ABO Blood-Group System / Q000276:immunology; D000941:Antigens / Q000276:immunology*; D002478:Cells, Cultured; D010064:Embryo Implantation; D005260:Female; D005331:Fetomaternal Transfusion; D005455:Fluorescent Antibody Technique; D006801:Humans; D010063:Ovum / Q000276:immunology*; D010920:Placenta / Q000276:immunology*; D011247:Pregnancy; D014184:Transplantation, Homologous; D014327:Trophoblasts / Q000276:immunology*
D000017:ABO Blood-Group System; D000941:Antigens
Die Antigenität der Trophoblastzellen und ihre Bedeutung für Plazentation und Tolerierung menschlicher allogener Früchte.