Suppression and enhancement of transformation of ferret peripheral blood mononuclear cells by mycobacteria.
The effect of heat killed Mycobacterium bovis on the phytohaemagglutinin (PHA) response of normal peripheral blood leucocytes from ferrets was dose dependent. Concentrations of 10(6) organisms ml-1 and below enhanced the response, whereas more than 10(6) organisms ml-1 suppressed it. This suppression correlated with cytotoxicity of M bovis for ferret peripheral blood leucocytes. Three environmental strains, M phlei, M smegmatis and M aurum were not cytotoxic and did not affect the PHA response but were found to be mitogenic at high concentrations.
D000818:Animals; D002335:Carnivora / Q000276:immunology*; D005289:Ferrets / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D009161:Mycobacterium / Q000276:immunology*; D009163:Mycobacterium bovis / Q000276:immunology*; D009170:Nontuberculous Mycobacteria / Q000276:immunology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013045:Species Specificity
D010835:Phytohemagglutinins