title: Lipids, lipoproteins, and endocrine profiles during pregnancy in the African green monkey (Cercopithecus aethiops).
abstract: In an attempt to establish relationships between the endocrine and lipid metabolism during pregnancy, the changes in total plasma cholesterol (TPC) and lipoprotein cholesterol that occur during pregnancy in the African green monkey were investigated longitudinally in ten females in relation to the changes in progesterone, estradiol, and fasting insulin concentrations. Respective means for TPC, high-density lipoprotein (HDL) cholesterol, and low-density lipoprotein (LDL) plus very low-density lipoprotein (VLDL) cholesterol were 343 +/- 35, 108 +/- 9, and 235 +/- 36 mg/dL prior to the estimated date of conception in ten females fed a high-fat, high-cholesterol diet. The concentration of these lipids fell to 225 +/- 31, 54 +/- 4, and 168 +/- 29 mg/dL for TPC (P less than 0.001), HDL cholesterol (P less than 0.001), and LDL + VLDL cholesterol (P less than 0.001), respectively, by midpregnancy (84 days). Progesterone concentrations increased during the first 60 days of pregnancy and were negatively correlated with HDL cholesterol concentrations (r = -0.57, P less than 0.02). After reaching their highest mean value, progesterone concentrations then plateaued at lower concentrations until parturition. The decrease in progesterone concentrations was associated with an initial rise in estradiol concentrations, which reached their highest concentrations in late pregnancy and were inversely correlated with HDL-cholesterol concentrations (r = -.32, P less than 0.01). Although glucose concentrations remained steady during gestation, insulin concentrations were elevated compared to postpartum concentrations (P less than 0.05) suggesting that insulin resistance occurred during the pregnancy in this nonhuman primate.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000818:Animals; D002521:Cercopithecus / Q000097:blood*; D002522:Chlorocebus aethiops / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D005865:Gestational Age; D006728:Hormones / Q000097:blood*; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D011247:Pregnancy; D011270:Pregnancy, Animal; D011374:Progesterone / Q000097:blood; D014280:Triglycerides / Q000097:blood
chemical_list: D006728:Hormones; D007328:Insulin; D008055:Lipids; D008074:Lipoproteins; D014280:Triglycerides; D011374:Progesterone; D004958:Estradiol; D002784:Cholesterol