title: Hyperresponsiveness to autacoids and autonomic drugs in lung parenchymal strips from sensitized guinea pigs.
abstract: The responsiveness of lung parenchymal strips isolated from actively sensitized guinea pigs to some selected autacoids (histamine, 5-hydroxytryptamine, bradykinin, and prostaglandins F2 alpha and l2) and autonomic drugs (acetylcholine, norepinephrine, methoxamine, and isoprenaline) was compared with that of strips from unsensitized animals. The concentration-response curves to the agonists, with the only exception of isoprenaline, in the sensitized group exhibited a left upward displacement (greater maximal effects and less effective concentration 50%) compared with those obtained in the unsensitized group. These results indicate the existence of a nonspecific increase in responsiveness of lung parenchymal strip isolated from sensitized animals.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001337:Autonomic Agents / Q000494:pharmacology*; D001920:Bradykinin / Q000494:pharmacology; D015237:Dinoprost; D011464:Epoprostenol / Q000494:pharmacology; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D007114:Immunization; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008168:Lung / Q000187:drug effects*; D008297:Male; D008729:Methoxamine / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology
chemical_list: D001337:Autonomic Agents; D011460:Prostaglandins F; D012701:Serotonin; D006632:Histamine; D015237:Dinoprost; D011464:Epoprostenol; D008729:Methoxamine; D007545:Isoproterenol; D000109:Acetylcholine; D001920:Bradykinin; D009638:Norepinephrine