Identification and determination of the S-methyl metabolite of captopril in human plasma by selected-ion monitoring gas chromatography-mass spectrometry.
The S-methyl metabolite of captopril was identified and determined in human plasma by positive chemical ionization selected-ion monitoring gas chromatography-mass spectrometry. After oral administration of 100 mg of captopril to healthy subjects, the maximum plasma level was 60-114 ng/mL. These data for the S-methyl metabolite of captopril were correlated to total and unchanged captopril levels. Captopril--identification and determination of the S-methyl metabolite in human plasma, gas chromatography-selected-ion monitoring mass spectrometry Gas chromatography-selected-ion monitoring mass spectrometry--determination of the S-methyl metabolite of captopril in human plasma after oral administration.
D001711:Biotransformation; D002216:Captopril / Q000097:blood*; D004355:Drug Stability; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D008745:Methylation; D011392:Proline / Q000031:analogs & derivatives*
D011392:Proline; D002216:Captopril