[Treatment of Jessner-Kanof disease with thalidomide].
Five patients present a Jessner-Kanof's lymphocytic infiltration of the skin with 6-year duration for 4 of them. The skin lesions are numerous on the face and the back and characteristic of this disease. Histologic examination shows a lymphocytic infiltrate in the dermis without any modification of epidermis. Direct immunofluorescent study is negative in all cases. In 3 cases, response to chloroquine had been inconsistent or negative. The 5 cases have a excellent result with 100 mg/day of Thalidomide. In 4 cases the skin lesions reappear when treatment is stopped. With a continuous treatment of 25-50 mg/day for more than 2 years, 3 of 5 patients have normal skin. Thalidomide appears to be the best treatment of Jessner-Kanof's disease.
D000328:Adult; D002986:Clinical Trials as Topic; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008179:Lupus Erythematosus, Discoid / Q000175:diagnosis; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000175:diagnosis / Q000188:drug therapy*; D013792:Thalidomide / Q000627:therapeutic use*
D013792:Thalidomide
Traitement de la maladie de Jessner et Kanof par la thalidomide.