Activation of aromatic amines to mutagens by various animal species including man.
2-Acetylaminofluorene, 2-aminofluorene, 4-aminobiphenyl, 2-naphthylamine, 2-aminoanthracene and benzidine were assayed for mutagenicity in the Ames test in the presence of hepatic microsomal preparations derived from mouse, hamster, rat, pig and man. Prior to each mutagenicity assay all activation systems were fully characterized with respect to mono-oxygenase and mixed-function amine oxidase activities. All compounds were metabolically activated to mutagens by all activation systems, but with markedly different efficiencies, hamster being the only species which readily activated all amines. The hamster also exhibited the highest ethoxyresorufin O-deethylase and dimethylaniline N-oxidase activities.
D015073:2-Acetylaminofluorene / Q000378:metabolism / Q000633:toxicity; D000588:Amines / Q000378:metabolism / Q000633:toxicity*; D000611:Aminobiphenyl Compounds / Q000378:metabolism / Q000633:toxicity; D000818:Animals; D000873:Anthracenes / Q000378:metabolism / Q000633:toxicity; D001560:Benzidines / Q000378:metabolism / Q000633:toxicity; D001711:Biotransformation; D006224:Cricetinae; D005449:Fluorenes / Q000378:metabolism / Q000633:toxicity; D006801:Humans; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism*; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects; D013045:Species Specificity; D013329:Structure-Activity Relationship; D013552:Swine
D000588:Amines; D000611:Aminobiphenyl Compounds; D000873:Anthracenes; D001560:Benzidines; D005449:Fluorenes; D009153:Mutagens; C006757:4-biphenylamine; C029876:benzidine; C012177:2-aminofluorene; C006593:2-anthramine; D015073:2-Acetylaminofluorene