[Effect of pregnancy on carbohydrate and lipid metabolism of the mother--I. Kinetics of various parameters of carbohydrate and lipid metabolism and of various hormones as a function of the length of pregnancy].
Numerous factors influence fetal weight increase and growth. To permit a discussion of biochemical influences on fetal growth, maternal substrates and hormones which influence lipid and carbohydrate metabolism were measured and their relationships were analyzed. In 173 patients the following substrates were measured between the 8th and 40th week of pregnancy: glucose in whole blood and urine, glycerin, triglycerides, total cholesterol, free cholesterol and the hormones HGH, HPRL, HPL, IRI and estriol (E3). A group of nonpregnant and a group of recently delivered women served as controls. The glucose concentration in the whole blood of the mother diminished during pregnancy from 88.3 mg/100 ml to 77.4 mg/100 ml (2 alpha less than 0.05, r = 0.47, n = 77). It was still below the value for the non-pregnant controls post partum (63.6 mg/100 ml as compared to 92.3 mg/100 ml). Glucosuria increased during pregnancy, reaching a maximum in the second trimester. The glycerin concentration was unchanged during pregnancy. As with the post-partial group (0.53 mg/100 ml) the values were lower than those for the non-pregnant control group (1.14 mg/100 ml). The triglyceride concentration increased during pregnancy from 90.3 mg/100 ml to 179.7 mg/100 ml (2 alpha less than 0.00004, r = 0.6, n = 29). In the second and third trimesters (162.9 mg/100 ml, 179.7 mg/100 ml) and post partum (162.3 mg/100 ml) the values were higher than that for the non-pregnant controls (101.5 mg/100 ml). (ABSTRACT TRUNCATED AT 250 WORDS)
D000328:Adult; D050260:Carbohydrate Metabolism; D002784:Cholesterol / Q000378:metabolism; D005260:Female; D005951:Glucose Tolerance Test; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000097:blood; D007700:Kinetics; D008055:Lipids / Q000097:blood*; D011247:Pregnancy
D006728:Hormones; D007328:Insulin; D008055:Lipids; D002784:Cholesterol
Untersuchungen zum Einfluss der Schwangerschaft auf den Kohlenhydrat- und Fettstoffwechsel der Mutter--Teil I: Die Kinetik einzelner Parameter des Kohlenhydrat- und Fettstoffwechsels sowie verschiedener Hormone in Abhängigkeit vom Schwangerschaftsalter.