title: Osteoporosis. Experimental and clinical studies.
abstract: Combined experimental and clinical research illustrates not only the multiplicity of questions for research on osteoporosis but also the difficulty of penetrating such a complicated clinical problem as treatment and prevention of osteoporosis. Without thorough knowledge of the pathomechanisms responsible for the development of the condition and a rational working hypothesis, any attempt to develop a new approach seems unlikely to succeed.
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000818:Animals; D001862:Bone Resorption / Q000517:prevention & control; D002118:Calcium / Q000172:deficiency / Q000378:metabolism; D002136:Calcium, Dietary / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D005260:Female; D006706:Homeostasis; D006801:Humans; D006887:Hydroxycholecalciferols / Q000008:administration & dosage; D007103:Immobilization; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D010280:Parathyroid Glands / Q000503:physiopathology; D010865:Pilot Projects; D051381:Rats; D014807:Vitamin D / Q000378:metabolism
chemical_list: D002136:Calcium, Dietary; D006887:Hydroxycholecalciferols; D014807:Vitamin D; D002118:Calcium; C008088:alfacalcidol