Superoxide dismutase acts as an enhancing factor for quercetin mutagenesis in rat-liver cytosol by preventing its decomposition.
The mutagenicity of quercetin towards Salmonella typhimurium TA98 was enhanced by rat-liver cytosol. The enhancing factors in the cytosol were separated into 4 fractions by gel filtration, and one of them was identified as superoxide dismutase (SOD). It is suggested that SOD increases the mutagenicity of quercetin by protecting it from degradation.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001711:Biotransformation; D003600:Cytosol / Q000378:metabolism; D004229:Dithiothreitol / Q000494:pharmacology; D004357:Drug Synergism; D005419:Flavonoids / Q000633:toxicity*; D008099:Liver / Q000378:metabolism; D009154:Mutation / Q000187:drug effects*; D010100:Oxygen / Q000378:metabolism; D011794:Quercetin / Q000633:toxicity*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects; D013482:Superoxide Dismutase / Q000378:metabolism
D005419:Flavonoids; D011794:Quercetin; D013482:Superoxide Dismutase; D001205:Ascorbic Acid; D010100:Oxygen; D004229:Dithiothreitol