title: Lipid peroxides, prostacyclin, and thromboxane A2 in runners during acute exercise.
abstract: We studied the effect of physical activity on lipid peroxidation and on the production of antiaggregatory, vasodilatory prostacyclin (epoprostenol, PGI2) and its endogenous antagonist, thromboxane A2 (TxA2) in 10 well-trained long-distance runners before, during, and after maximal exercise on a cycle ergometer. Pre-exercise levels of lipid peroxides (2.0 +/- 0.4 mumol X l-1, means +/- SD), plasma immunoreactive 6-keto-prostaglandin F1 alpha (i 6-keto-PGF1 alpha, a metabolite of PGI2) (192.8 +/- 51.7 pmol X l), and serum immunoreactive thromboxane B2 (i TxB2, a metabolite of TxA2) (703.3 +/- 290.1 nmol X l) did not differ from those of 10 non-athletic controls. Plasma i 6-keto-PGF1 alpha was increased at the seventh minute of the exercise test, but not any more at the end of the exercise or 30 min later. Lipid peroxides or i TxB2 did not change. Our data suggest that the changes of the PGI2/TxA2-ratio induced by long-term or acute physical exercise are too small to explain the protective effect of physical fitness against coronary heart disease.
mesh_terms: D000293:Adolescent; D000328:Adult; D011464:Epoprostenol / Q000097:blood*; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D005082:Physical Exertion; D012420:Running; D013928:Thromboxane A2 / Q000097:blood*; D013931:Thromboxanes / Q000097:blood*
chemical_list: D008054:Lipid Peroxides; D013931:Thromboxanes; D013928:Thromboxane A2; D011464:Epoprostenol