The role of DNA repair processes in the response of human tumors to fractionated radiotherapy.
The relationship of inherent radiosensitivity, sublethal and potentially lethal damage repair to radiation therapy is not yet fully explained. I will examine how these various repair processes might be relevant to radiotherapy, based on laboratory investigation of human tumor cells in vitro. Although radiocurability is a complex function, recovery processes manifested in the post-radiation period may be a determinant of radiocurability.
D001260:Ataxia Telangiectasia / Q000473:pathology; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D004247:DNA / Q000528:radiation effects; D004260:DNA Repair; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000528:radiation effects; D006801:Humans; D008545:Melanoma / Q000473:pathology; D009062:Mouth Neoplasms / Q000473:pathology; D009369:Neoplasms / Q000532:radiotherapy*; D011836:Radiation Tolerance; D014983:Xeroderma Pigmentosum / Q000473:pathology
D004247:DNA