[Yeast resistance to polyene antibiotics. III. Phenotypic analysis of polyene-resistant sterol mutants of Saccharomyces cerevisiae yeasts].
The pleiotropic effects of nystatin resistant mutations have been studied. It has been shown that resistance to nystatin is often accompanied by temperature-sensitivity and, in some cases, by osmotic remedial sensitivity. The dependence of the expression of the mutations on temperature is demonstrated. A new type of conditional nystatin-dependent mutants is found. All nys2 mutants have a defected membrane and are stained on a methylene blue containing media. At the same time, the mutations under investigation do not affect the respiratory competence and the exoenzyme activity of acid phosphatases.
D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors*; D004352:Drug Resistance, Microbial; D005799:Genes, Dominant / Q000187:drug effects; D005808:Genes, Recessive / Q000187:drug effects; D009154:Mutation; D009761:Nystatin / Q000037:antagonists & inhibitors; D010641:Phenotype; D011090:Polyenes / Q000037:antagonists & inhibitors*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics; D013261:Sterols; D013696:Temperature; D015003:Yeasts / Q000187:drug effects* / Q000235:genetics
D000900:Anti-Bacterial Agents; D011090:Polyenes; D013261:Sterols; D009761:Nystatin
Rezistentnost' drozhzheĭ k polienovym antibiotikam. Soobshchenie III. Femotipicheskiĭ analiz polienrezistentnykh sterinovykh mutantov drozhzheĭ Saccharomyces cerevisiae.