[Proteolytic degradation of nuclear matrix proteins in rat liver and Zajdela ascites hepatoma].
Long-term incubation of rat liver nuclei (particularly in 2M NaCl) led to a decrease in the yield of the nuclear matrix. However, the electrophoretic pattern of nuclear matrix proteins remained essentially unchanged. In Zajdela's ascites hepatoma, long-term incubation of the nuclei resulted in lamina proteolysis. The proteolysis was partly inhibited by phenylmethylsulfonyl fluoride in high concentrations.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D010450:Endopeptidases / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008114:Liver Neoplasms, Experimental / Q000201:enzymology*; D009363:Neoplasm Proteins / Q000378:metabolism*; D010664:Phenylmethylsulfonyl Fluoride / Q000494:pharmacology; D011480:Protease Inhibitors; D011506:Proteins / Q000378:metabolism*; D051381:Rats
D009363:Neoplasm Proteins; D011480:Protease Inhibitors; D011506:Proteins; D010664:Phenylmethylsulfonyl Fluoride; D010450:Endopeptidases
Proteoliticheskiĭ raspad belkov iadernogo matriksa pecheni i astsitnoĭ gepatomy Zaĭdelia krysy.