Effects of antibiotics on adhesion of enterotoxigenic Escherichia coli strains.
Subinhibitory concentrations of 28 antibiotics were tested for their effects on MRHA patterns of four enterotoxigenic Escherichia coli strains possessing colonization factor antigens CFA/I, CFA/II or CFA/III. Only penicillin G, oleandomycin, doxycycline and minocycline inhibited the haemagglutination pattern of three Escherichia coli strains with CFA/I and CFA/II when added to the medium culture at concentrations ranging from 1/2 to 1/50 of the MIC. At the same concentrations they also decreased the adhesion index of the four strains to human intestinal cells. However, neither the specific agglutination of bacterial cells with CFA antisera nor the production of CFAs was affected.
D000268:Adhesiveness; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000942:Antigens, Bacterial / Q000276:immunology; D003470:Culture Media; D004848:Epithelium / Q000382:microbiology; D004926:Escherichia coli / Q000187:drug effects* / Q000276:immunology / Q000472:pathogenicity; D036781:Fimbriae Proteins; D006384:Hemagglutination / Q000187:drug effects*; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007413:Intestinal Mucosa / Q000382:microbiology
D000900:Anti-Bacterial Agents; D000942:Antigens, Bacterial; D003470:Culture Media; C022924:colonization factor antigens; D036781:Fimbriae Proteins