Homozygosity of HLA-B27 antigen in the recipient and susceptibility to the corneal allograft reaction.
Our series consists of six penetrating grafts to recipients who were carriers of homozygous HLA-B27 antigen. The donor cornea had only a single or, in one case, no HLA-B27 antigen and thus all presented with at least one incompatible HLA-B antigen to the recipient. Five of six grafts failed, four due to an allograft reaction; in one case corneal oedema of unknown aetiology developed 10 months postoperatively. These results give further support to the hypothesis that the recipients bearing HLA-B27 antigen form an 'at risk' group.
D000328:Adult; D000368:Aged; D003315:Cornea / Q000473:pathology; D016039:Corneal Transplantation; D005260:Female; D006084:Graft Rejection; D006680:HLA Antigens / Q000235:genetics*; D015796:HLA-B27 Antigen; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D014184:Transplantation, Homologous
D006680:HLA Antigens; D015796:HLA-B27 Antigen