title: Tyramine is a major mutagen precursor in soy sauce, being convertible to a mutagen by nitrite.
abstract: Tyramine was identified as a new mutagen precursor in Japanese soy sauce, becoming mutagenic after treatment with nitrite under acidic conditions. The mutagenic compound was identified as 4-(2-aminoethyl)-6-diazo-2,4- cyclohexadienone , and its specific mutagenic activity was 112 revertants/micrograms towards Salmonella typhimurium TA100 without S9 mix.
mesh_terms: D009152:Mutagenicity Tests; D009153:Mutagens / Q000032:analysis; D009573:Nitrites; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013025:Glycine max / Q000032:analysis / Q000633:toxicity; D014439:Tyramine / Q000032:analysis / Q000633:toxicity*
chemical_list: D009153:Mutagens; D009573:Nitrites; D014439:Tyramine