Effects of insulin in vitro on lipogenesis and fatty acid uptake in white adipose tissue of Zucker rats aged 10 days.
Adipose-tissue lipogenesis and fatty acid uptake in vitro were higher in obese than in lean Zucker rats aged 10 days. On average, insulin stimulated each of these two metabolic pathways to the same extent in both genotypes. However, in fa/fa pups, we observed that insulin stimulation decreased when adipose-tissue weight increased.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D005227:Fatty Acids / Q000378:metabolism*; D066298:In Vitro Techniques; D007328:Insulin / Q000494:pharmacology*; D008055:Lipids / Q000096:biosynthesis*; D009765:Obesity / Q000378:metabolism; D051381:Rats; D011924:Rats, Zucker
D005227:Fatty Acids; D007328:Insulin; D008055:Lipids