title: [Efficacy and tolerability of Negram Forte in the treatment and prevention of urinary infections in urologic surgery].
abstract: The authors sought to assess the efficacy and tolerance of a new oral form of nalidixic acid in the treatment of infections encountered in urological surgery. The study was based upon 30 cases. The urine was considered to be infected when more than 10(5)/ml organisms were present. Amongst 27 patients undergoing surgery, in 26 cases the operation was an endo-cavitary procedure involving the upper or lower urinary tract. The 3 non-surgical cases consisted of one patient with cystitis and two with prostatitis. In 6 patients, treatment was preventive, the urine being sterile before urological surgery. In the other 24, infection was present at the time that treatment was begun. E. coli present in 20 patients was the predominant organism in the series. Tolerance of treatment was perfect in 27 cases. In the 6 cases of preventive treatment, prescription of the drug prevented a postoperative infection. In the 24 patients receiving curative treatment, there were 7 failures (29%) and 3 late recurrences (12.5%). Failures were all the more frequent when the dose was lower. The authors equally felt that the prescription of 4 grams per day in one case was unsuitable. Organisms isolated when treatment was seen to have failed were all resistant to nalidixic acid. In the context of urological surgery, where there is often a cause of reinfection (catheters), the prescription of a high dose of the drug is an essential factor in decreasing the risk factor inherent in treatment.
mesh_terms: D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009268:Nalidixic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D011292:Premedication; D013997:Time Factors; D014551:Urinary Tract / Q000601:surgery; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000517:prevention & control
chemical_list: D009268:Nalidixic Acid
vernacular_title: Efficacité et tolérance du negram forte dans le traitement et la prévention des infections urinaires en chirurgie urologique.