Inhibition of growth of hair follicles by a lectin-like substance from rat skin.
A small molecular weight (5 000-10 000) substance has been isolated from rat skin by affinity chromatography on a column of acid-hydrolysed Sepharose. The substance agglutinates rabbit red blood cells, inhibits DNA synthesis in rat hair follicles, and causes the appearance of autophagic vacuoles in the epithelial cells of the lower follicle bulb.
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D006131:Growth Inhibitors / Q000302:isolation & purification*; D006197:Hair / Q000254:growth & development*; D037102:Lectins / Q000302:isolation & purification / Q000494:pharmacology*; D008970:Molecular Weight; D051381:Rats; D012867:Skin / Q000032:analysis*
D006131:Growth Inhibitors; D037102:Lectins; D004247:DNA