[Capacity of triterpene glycosides from holothurians to stimulate antibacterial resistance in a model of experimental murine salmonellosis].
When injected intraperitoneally into mice in doses of 40.0-0.4 microgram, Cucumarioside, the preparation of triterpene glycosides obtained from sea cucumbers (Cusumaria japonica), enhanced the resistance of the animals to the subsequent challenge with Salmonella typhimurium. The study of the duration of the persistence of salmonellae in mice receiving the preparation in a dose of 0.001 microgram revealed a decrease in the contamination of their organs. The same dose of the preparation stimulated the phagocytic activity of peritoneal exudate cells with salmonellae showing decreased cytopathogenic action. This suggests that Cucumarioside enhances nonspecific protective factors, activates the macrophagal system and facilitates the development of complete phagocytosis.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004447:Echinodermata; D006027:Glycosides; D007113:Immunity, Innate / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010587:Phagocytosis / Q000187:drug effects; D012481:Salmonella Infections, Animal / Q000188:drug therapy* / Q000276:immunology / Q000382:microbiology; D012486:Salmonella typhimurium; D012616:Sea Cucumbers; D013268:Stimulation, Chemical; D013997:Time Factors; D014315:Triterpenes / Q000008:administration & dosage / Q000276:immunology*
D006027:Glycosides; D014315:Triterpenes; C033504:cucumarioside
Sposobnost' triterpenovykh glikozidov iz goloturiĭ stimulirovat' antibakterial'nuiu ustoĭchivost' na modeli éksperimental'nogo sal'monelleza mysheĭ.