Testicular function after renal transplantation: comparison of Cyclosporin A with azathioprine and prednisone combination regimes.
Testicular function was assessed in 24 men after renal transplantation who were on either Cyclosporin A (CSA) (8 men) or a combination of azathioprine and prednisone (AZP) (16 men) as immunosuppressive therapy. The different regimes were not associated with any differences in clinical or hormonal (LH, FSH, prolactin, testosterone, estradiol) indices of testicular function although adrenal androgen (dehydroepiandrosterone sulphate) was suppressed in prednisone-treated men. Overall, however, poor graft function was associated with abnormal testicular function. Renal allograft function rather than immunosuppressive regime was the major determinant of gonadal function.
D000328:Adult; D000818:Animals; D001379:Azathioprine / Q000627:therapeutic use*; D003524:Cyclosporins / Q000627:therapeutic use*; D004338:Drug Combinations; D005298:Fertility / Q000187:drug effects; D006085:Graft Survival / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000502:physiology; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use*; D013737:Testis / Q000187:drug effects / Q000502:physiology*
D003524:Cyclosporins; D004338:Drug Combinations; D001379:Azathioprine; D011241:Prednisone