[Effect of gamma radiation on the immunobiological and immunochemical properties of cholera exotoxin. III. The serological activity and immunochemical properties of irradiated unpurified toxin].
The immunochemical properties and serological activity of irradiated preparations of crude cholera exotoxin have been studied. This study has revealed that with the increase of the dose of ionizing radiation changes occur in the physico-chemical properties of the preparations of the toxin, which leads to an increase in the electrophoretic motility of the protein components of the toxin, to the aggregation and polymerization of individual fragments. The preparations of antigen exotoxins have been shown to retain their serological activity within the range of radiation doses under study (10-350 kGy).
D000942:Antigens, Bacterial / Q000032:analysis / Q000528:radiation effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004307:Dose-Response Relationship, Radiation; D004768:Enterotoxins / Q000276:immunology / Q000528:radiation effects*; D005098:Exotoxins / Q000276:immunology / Q000528:radiation effects*; D005720:Gamma Rays; D007120:Immunochemistry; D007158:Immunologic Techniques
D000942:Antigens, Bacterial; D004768:Enterotoxins; D005098:Exotoxins; C037420:stN protein, Vibrio cholerae
Vliianie gamma-izlucheniia na immunobiologicheskie i immunokhimicheskie svoĭstva kholernogo ékzotoksina. Soobshchenie III. Serologicheskaia aktivnost' i immunokhimicheskie svoĭstva obluchennogo neochischennogo toksina.