The isolation and characterization of an insulin-releasing tetrapeptide from urines of patients with lipoatrophic diabetes.
The tetrapeptide pyroGlu-Glu-Asp-GlyOH and its gamma-amide have been isolated from the urines of lipodystrophic patients with insulin-resistant diabetes. Both peptides induce insulin release only at high blood glucose levels.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003923:Diabetes Mellitus, Lipoatrophic / Q000652:urine*; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D009842:Oligopeptides / Q000302:isolation & purification / Q000502:physiology / Q000652:urine*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D007328:Insulin; D009842:Oligopeptides; C041987:pyroglutamyl-glutamyl-asparaginyl-glycine; C041988:gamma-(pyroglutamyl-glutamyl-asparaginyl-glycine)amide; D011761:Pyrrolidonecarboxylic Acid