title: [Early pancreatic lesions induced by N-nitroso-bis(2-hydroxypropyl) amine in the golden Syrian hamster].
abstract: Early lesions of the exocrine pancreas of the Syrian Golden Hamster induced by lifetime weekly oral or subcutaneous administration of N-nitroso-bis (2 hydroxy propyl) amine (250 mg/kg) were studied by light and electron microscopy and autoradiography. There were no pathological differences according to the way of administration. The histogenesis of induced pancreatic neoplasms may be summed up as follows: hyperplasia of ductular cells with new islet cell formation that lead to the development of peri or intra insular cystic ductules which become cystedenomas and carcinomas.
mesh_terms: D000818:Animals; D001345:Autoradiography; D006224:Cricetinae; D007515:Islets of Langerhans / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D009602:Nitrosamines / Q000633:toxicity*; D010179:Pancreas / Q000473:pathology; D010182:Pancreatic Diseases / Q000139:chemically induced*; D010190:Pancreatic Neoplasms / Q000139:chemically induced; D013997:Time Factors
chemical_list: D009602:Nitrosamines; C012457:diisopropanolnitrosamine
vernacular_title: Lésions pancréatiques précoces induites par le N-nitroso-bis (2 hydroxy propyl) amine chez le syrian golden hamster.