title: Hypertension following carotid endarterectomy: the role of cerebral renin production.
abstract: The cause of hypertension in the immediate postoperative period after carotid endarterectomy is unknown. In order to elucidate the etiology of hypertension following carotid endarterectomy, blood samples were drawn intraoperatively from internal jugular vein and external carotid artery prior to and subsequent to carotid endarterectomy in 20 patients. Renin measurement in these samples produced a ratio of internal jugular vein (cerebral) to external carotid artery (systemic). In pre-endarterectomy samples, this cerebral-to-systemic ratio was 1.0 +/- 0.17. However, in the six patients hypertensive postoperatively, this ratio was significantly (p less than 0.02) higher at 1.39 +/- 0.4 than in 14 patients not hypertensive, 0.99 +/- 0.28. Although this ratio in hypertensive patients reverted to 1.12 +/- 0.24 in the postoperative period, the present study suggests a relation between hypertension after carotid endarterectomy and renin production by the brain.
mesh_terms: D000368:Aged; D001921:Brain / Q000378:metabolism*; D002340:Carotid Artery Diseases / Q000601:surgery*; D004691:Endarterectomy / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000209:etiology; D012083:Renin / Q000097:blood / Q000378:metabolism*
chemical_list: D012083:Renin