title: Localization of free secretory component in pleomorphic adenomas of minor salivary gland origin.
abstract: Secretory component (a glycoprotein) is an antigenically distinct portion of the secretory immunoglobulin A, which has been identified in a number of normal and neoplastic epithelial cells. Localization of secretory component was determined in pleomorphic adenomas of minor salivary gland origin using the four-step peroxidase-antiperoxidase technique. Antiserum that detected only free secretory component (FSC) was used. Staining for secretory component was noted in the epithelium that lined duct-like spaces; but was absent in myoepithelial cells and mucous acini. These findings suggest a role for FSC in evaluating the histogenesis of various salivary gland neoplasms.
mesh_terms: D000236:Adenoma / Q000276:immunology*; D004848:Epithelium / Q000276:immunology; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007071:Immunoglobulin A, Secretory / Q000032:analysis*; D012468:Salivary Gland Neoplasms / Q000276:immunology*
chemical_list: D007071:Immunoglobulin A, Secretory