[Recent advances in the biochemistry and characteristics of tumor viruses and the biochemistry of tumor development in man and animal].
The transformation of cells in animals into tumour cells is mainly evoked by tumour viruses: These are taken into the genome and evoke the formation of transforming proteins (tumour antigens), which partly acts as protein kinases and cause changes of the membrane proteins. Thus the regulation of the cell division is excluded. The DNA-molecules which are in their structure analogous or much equal to the desoxyribonucleic acids of the proviruses and the tumour viruses are normal constituents of the nucleus-DNA of the man and the animals and are called cellular oncogens in contrast to the viral oncogens. Under physiologic conditions the cellular oncogens are not or only at a very small extent used for the formation of proteins. Some tumour viruses cause a formation of tumours only by means of an activation of cellular oncogens, i.e. by efficacy as promotor sections. In man most tumours develop under the influence of carcinogens which lead to the development of repair processes on the DNA and to the new organisation of the arrangement of DNA-molecules. Here the cellular oncogens are activated, which evoke an increased synthesis of transforming proteins. Thus, on principle the development of tumours takes place in the same way in man and animal. In the most tumour forms of man oncogenic DNA-molecules are proved, which in their structure correspond to the viral oncogens of animals.
D000818:Animals; D004267:DNA Viruses / Q000378:metabolism / Q000648:ultrastructure; D004279:DNA, Viral / Q000235:genetics; D006801:Humans; D007938:Leukemia / Q000209:etiology; D009369:Neoplasms / Q000209:etiology*; D009784:Occupational Diseases / Q000209:etiology; D009858:Oncogenic Viruses / Q000378:metabolism*; D011200:Poultry; D011323:Primates; D012190:Retroviridae / Q000378:metabolism; D012509:Sarcoma / Q000209:etiology
D004279:DNA, Viral
Neuere Erkenntnisse zur Biochemie und zu den Eigenschaften von Tumorviren sowie zur Biochemie der Tumorentwicklung bei Mensch und Tier.