[Features of vascular reactivity, sodium metabolism and its humoral regulation in healthy subjects with a family history of hypertension].
The examination of 140 normal individuals with a family history of essential hypertension (FHEH) showed a number of differences in their cardiovascular and renin-aldosterone responses as compared to 170 normal subjects of the control group. Two years later the results were analyzed once again with regard to blood pressure changes. It turned out that subjects with a FHEH and an unfavourable pattern of blood pressure changes over two years exhibited elevated response of cutaneous vessels to angiotensin and noradrenaline, a higher threshold of gustatory sensitivity to salt and an increased BP response to psychoemotional stress already during the first examination. It is concluded that the most informative markers of the prehypertension state among the genetically determined features characteristic of healthy individuals with a FHEH are changes in sodium metabolism and regulation which are responsible for the development of vascular hyperactivity.
D000328:Adult; D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II; D001794:Blood Pressure; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine; D012083:Renin / Q000097:blood; D012965:Sodium Chloride; D013315:Stress, Psychological / Q000503:physiopathology; D013652:Taste Threshold
D000804:Angiotensin II; D012965:Sodium Chloride; D000450:Aldosterone; D012083:Renin; D009638:Norepinephrine
Osobennosti sosudistoĭ reaktivnosti, obmena natriia i ego gormonal'noĭ reguliatsii u zdorovykh lits s nasledstvennoĭ otiagoshchennost'iu po gipertonicheskoĭ bolezni.