title: Correlation between carcinoembryonic antigen in gastric cancer tissue and survival of patients with gastric cancer.
abstract: Gastric cancer specimens obtained from 162 patients who had undergone radical surgery with the routine postoperative administration of both mitomycin C and 5-fluorouracil were stained for carcinoembryonic antigen (CEA) by the unlabeled antibody enzyme technique. The CEA (-/+) group (92 cases) consisting of the negative and weakly positive staining cases had a significantly better survival rate over a period of 5 years than the CEA (++) group (70 cases) which comprised only strongly positive cases. The CEA (-/+) group with differentiated adenocarcinoma had the best prognosis and the 5-year survival rate was significantly higher than those of the other three groups. Among stage II and III carcinomas, the postoperative survival rate was significantly better in the CEA (-/+) group than in the CEA (++) group. Among the patients with lymph node metastasis, the postoperative survival rate was low, especially in the CEA (++) group. The present data suggest that staining for CEA in tissue sections of stomach carcinoma may be helpful in differentiating among tumors that appear similar by conventional histological methods, thus providing a new means for obtaining more precise prognostic information.
mesh_terms: D002272:Carcinoembryonic Antigen / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D011379:Prognosis; D013270:Stomach / Q000276:immunology; D013274:Stomach Neoplasms / Q000276:immunology* / Q000401:mortality / Q000473:pathology
chemical_list: D002272:Carcinoembryonic Antigen