Mutagenicity of urine of various species fed N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide or 2-amino-4-(5-nitro-2-furyl)thiazole.
Rats, mice and hamsters, which are susceptible to the bladder carcinogenesis by N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide (FANFT), and guinea pigs, which are not, were fed a diet containing 0.188% FANFT or 0.188% 2-amino-4-(5-nitro-2-furyl)thiazole (ANFT) for 1 week and their urine was then examined for mutagenicity for S. typhimurium TA100. The mutagenicities of the urine of these species fed FANFT were approximately equal. Similarly, that of the urine of these species fed ANFT were also approximately equal. However, the urine from FANFT-fed animals was approximately 10 times as mutagenic as that from ANFT-fed animals. ANFT was detected only in the urine of rats, mice or hamsters fed FANFT. A positive correlation between the susceptibility toward bladder carcinogenesis by FANFT and urinary ANFT excretion was demonstrated, although the correlation between this susceptibility and urine mutagenicity was lacking.
D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000633:toxicity; D006224:Cricetinae; D005200:FANFT / Q000031:analogs & derivatives / Q000633:toxicity*; D005260:Female; D006168:Guinea Pigs; D008647:Mesocricetus; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D009581:Nitrofurans / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects; D013045:Species Specificity; D013844:Thiazoles / Q000633:toxicity*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced; D014556:Urine
D002273:Carcinogens; D009153:Mutagens; D009581:Nitrofurans; D013844:Thiazoles; C001252:nefurthiazole; C024885:ANFT; D005200:FANFT