title: Interaction of C1q with beta 2-microglobulin.
abstract: Beta 2-microglobulin aggregated with glutaric dialdehyde was efficiently bound to C1q in fluid and solid phase assay systems. Furthermore, affinity chromatography experiments suggested reactivity of monomeric beta 2-microglobulin with C1q. In spite of its C1q binding capacity, the aggregated beta 2-microglobulin did not activate the C1 complex in serum. This however, might have been due to the mode of aggregation.
mesh_terms: D001665:Binding Sites; D003166:Complement Activating Enzymes / Q000378:metabolism*; D003167:Complement Activation; D003172:Complement C1 / Q000378:metabolism; D015922:Complement C1q; D006801:Humans; D066298:In Vitro Techniques; D011487:Protein Conformation; D001613:beta 2-Microglobulin / Q000378:metabolism*
chemical_list: D003172:Complement C1; D001613:beta 2-Microglobulin; D015922:Complement C1q; D003166:Complement Activating Enzymes