Immune reactions to Wuchereria bancrofti infections in Tanzania. I. Serum-mediated adherence of leucocytes to microfilariae in vitro, using serum from different groups of patients.
Studies on serum-mediated adherence of leucocytes to microfilariae of Wuchereria bancrofti in vitro were carried out in an area of Tanzania endemic for filarial infections. Patients were divided into age-matched groups according to parasitological and clinical conditions. No adherence was seen with serum from microfilariae-positive patients (with or without clinical disease). A slightly, but not statistically significantly, higher prevalence of adherence-positive sera was found among hydrocele patients (27%) and lymphangitis/elephantiasis patients (33%) than among endemic control patients (20%). These three positive groups exhibited a marked difference in age distribution of prevalence of positivity, with very high prevalences found among young hydrocele patients (48%) and old lymphangitis/elephantiasis patients (63%). The hydrocele fluid from hydrocele patients with adherence-positive serum also mediated adherence.
D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000276:immunology; D004604:Elephantiasis / Q000276:immunology; D005368:Filariasis / Q000276:immunology*; D006801:Humans; D007104:Immune Adherence Reaction; D007962:Leukocytes / Q000276:immunology*; D008205:Lymphangitis / Q000276:immunology; D008297:Male; D008842:Microfilariae / Q000276:immunology; D008875:Middle Aged; D006848:Testicular Hydrocele / Q000276:immunology; D014958:Wuchereria bancrofti / Q000276:immunology
D000906:Antibodies