Aminophylline reversal of diazepam sedation.
A double-blind randomised study was performed to investigate whether aminophylline reversed the sedative effect of diazepam. Thirty-two patients undergoing genito-urinary surgery with spinal or topical anaesthesia were given diazepam to maintain a state of deep sedation. Postoperatively patients received either aminophylline (60-120 mg) or physiological saline intravenously. The aminophylline group showed a rapid reversal of sedation, which persisted throughout the observation period of 2 hours. No such effect was seen in the patients who received saline and the difference was still obvious after 2 hours. It is concluded that aminophylline is a potent antagonist to the sedative effect of diazepam.
D000328:Adult; D000368:Aged; D000628:Aminophylline / Q000494:pharmacology*; D000772:Anesthesia, Local; D000775:Anesthesia, Spinal; D002986:Clinical Trials as Topic; D003975:Diazepam / Q000037:antagonists & inhibitors*; D004311:Double-Blind Method; D006801:Humans; D006993:Hypnotics and Sedatives / Q000037:antagonists & inhibitors*; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011897:Random Allocation; D013997:Time Factors
D006993:Hypnotics and Sedatives; D000628:Aminophylline; D003975:Diazepam