title: Intracellular electrolytes and hormonal parameters during weight reduction.
abstract: The mechanisms of the blood pressure lowering effect of weight reduction have not yet been fully elucidated. In this study the intracellular electrolyte composition and hormonal parameters were monitored in 12 obese subjects during a 10-day diet with 800 kcal/day. A decrease in intracellular free Na+ (p less than 0.05) and Mg2+ (p less than 0.01) and in total intracellular K+ (p less than 0.05) was observed. Furthermore, plasma aldosterone and renin activity (p less than 0.05) increased, probably due to a moderate simultaneous salt restriction. There was also an increase in plasma PGI2 concentration (p less than 0.05). The observed decrease in intracellular free Na+ may be caused by salt restriction. The decrease in intracellular K+ and free Mg2+ may be induced by hormonal factors, e.g. an altered insulin secretion. Possible causes for the known hemodynamic effects of weight reduction are the diminution of intracellular Na+ and the increase in plasma PGI2.
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood*; D001794:Blood Pressure; D001835:Body Weight; D004038:Diet, Reducing; D004573:Electrolytes / Q000097:blood*; D011464:Epoprostenol / Q000097:blood; D005260:Female; D006728:Hormones / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D009765:Obesity / Q000097:blood*; D012083:Renin / Q000097:blood*; D013931:Thromboxanes / Q000097:blood
chemical_list: D004573:Electrolytes; D006728:Hormones; D007328:Insulin; D013931:Thromboxanes; D000450:Aldosterone; D011464:Epoprostenol; D012083:Renin