H-Y antibodies recognize the H-Y transplantation antigen.
The question is raised whether the H-Y transplantation antigen, as defined by skin graft rejection, is the same as the "male-specific" antigen that is identified by H-Y antibodies. We have addressed that question by injecting female mice of the inbred C57BL/6 strain with serologically defined H-Y antigen, and measuring the response of those female mice to skin grafts from intrastrain male mice. The results of our study indicate that the "two" male antigens are crossreactive or identical.
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D002645:Chickens; D005260:Female; D006084:Graft Rejection; D006182:H-Y Antigen / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D010053:Ovary / Q000276:immunology; D012727:Sex Characteristics; D016038:Skin Transplantation; D013737:Testis / Q000276:immunology; D014181:Transplantation Immunology
D000906:Antibodies; D006182:H-Y Antigen