title: Relationship among peripheral glucose uptake, oxygen consumption, and glucose turnover in postabsorptive man.
abstract: To assess the importance of glucose uptake by muscle in determining total glucose utilization in the basal state, forearm glucose uptake (FGU), reflecting mainly skeletal muscle metabolism, and glucose turnover using [3-3H]glucose were studied simultaneously in 17 postabsorptive normal men. Mean +/- SE glucose disappearance was 2.36 +/- 0.14 mg/kg X min, amounting to 170 +/- 9 mg/min, while FGU was 0.049 +/- 0.009 mg/100 ml forearm X min. When the latter was calculated in terms of skeletal muscle in the body as a whole, muscle glucose utilization was found to be 24.7 +/- 4.5 mg/min, comprising only 13.5 +/- 1.9% of the total glucose disappearance. Forearm oxygen consumption was 6.6 +/- 0.5 mumol/100 ml forearm X min, of which only 26 +/- 5% could be accounted for by concurrent glucose uptake. These results suggest that in the basal state, glucose uptake by skeletal muscle accounts for 1) only a small percentage of total glucose disappearance and 2) only a minor proportion of peripheral oxygen consumption, which may be more dependent on lipid oxidation.
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D005542:Forearm; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D008657:Metabolic Clearance Rate; D009132:Muscles / Q000378:metabolism*; D010084:Oxidation-Reduction; D010101:Oxygen Consumption; D011865:Radioisotope Dilution Technique
chemical_list: D001786:Blood Glucose; D007773:Lactates; D019344:Lactic Acid; D005947:Glucose