title: The human hypothalamic LHRH precursor is the same size as that in rat and mouse hypothalamus.
abstract: The synthesis of the decapeptide luteinizing hormone releasing hormone (LHRH) in human, rat and mouse brain has been investigated by studying the in vitro translation products of Poly A+ mRNA extracts from the hypothalamus. The translation products of all three species contained a single 28000 MW polypeptide which immunoprecipitated with a specific anti-LHRH serum. This polypeptide was not present in the translation products of Poly A+ mRNA extracts from the hypothalamus of the hypogonadal mouse, a mutant strain totally deficient in LHRH. These results show that in the human, rat and normal mouse, LHRH is synthesized as a component of a precursor peptide with a molecular weight of 28000.
mesh_terms: D000368:Aged; D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000096:biosynthesis*; D006801:Humans; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D051379:Mice; D008970:Molecular Weight; D014176:Protein Biosynthesis; D011498:Protein Precursors / Q000302:isolation & purification*; D051381:Rats; D013045:Species Specificity
chemical_list: D011498:Protein Precursors; D007987:Gonadotropin-Releasing Hormone