[Specific 125I-insulin binding by hepatocyte plasma membranes and nuclear envelopes in experimental hyperinsulinemia, alloxan diabetes and starvation].
A comparative study has been carried out of the insulin-receptor interaction in rat liver plasma membrane and nuclear envelope under experimental hyperinsulinemia (14 days) and hypoinsulinemic states (3 days alloxan diabetes, 2 days fasting, and joint action of these factors). In all the cases, including additivity of the receptorotropic effects of diabetes and fasting, the changes in levels of specific binding of 125I-insulin and indices, reflecting receptor number, were unidirectional both in the plasma membrane and nuclear envelope. Some divergences were observed for indices reflecting the affinity changes of the receptors from different sources. It is suggested that in insulin-induced regulation of insulin receptor number the relationship between intracellular membrane receptors and receptors in the plasma membrane and nuclear envelope is the same.
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006946:Hyperinsulinism / Q000378:metabolism*; D007328:Insulin / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008099:Liver / Q000378:metabolism*; D008297:Male; D009685:Nuclear Envelope / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D011919:Rats, Inbred Strains; D011972:Receptor, Insulin / Q000378:metabolism; D013217:Starvation / Q000378:metabolism*; D013997:Time Factors
D007328:Insulin; D007457:Iodine Radioisotopes; D011972:Receptor, Insulin
Spetsificheskoe sviazyvanie 125I-insulina plazmaticheskimi membranami i obolochkami iader gepatotsitov pri éksperimental'noĭ giperinsulinemii, alloksanovom diabete i golodanii.