Naproxen sodium vs. a combination of aspirin, phenacetin, caffeine and codeine phosphate for pain after major gynecologic surgery. A multicenter comparison.
In this multicenter study a nonnarcotic analgesic available for moderate pain, naproxen sodium, 550 mg, was compared to a combination that is used extensively for moderate to severe pain, aspirin, phenacetin, caffeine and codeine phosphate (APC/C) (60 mg of codeine phosphate). Women with pain after major gynecologic surgery reported a similar pattern in pain reduction with the two medications except for a relatively sharper increase in pain intensity between four and six hours after administration of APC/C. A smaller number of patient complaints suggested that naproxen sodium was better tolerated than APC/C.
D001241:Aspirin / Q000627:therapeutic use*; D002110:Caffeine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003061:Codeine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery*; D006801:Humans; D007044:Hysterectomy; D007247:Infertility, Female / Q000601:surgery; D009288:Naproxen / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000188:drug therapy*; D010615:Phenacetin / Q000627:therapeutic use*
D004338:Drug Combinations; D002110:Caffeine; D009288:Naproxen; D010615:Phenacetin; D001241:Aspirin; D003061:Codeine