[Action of desoxyfructo-serotonin on Mycobacterium leprae. Results of inoculation of human biopsy specimens in the mouse after a year of treatment].
M. leprae, extracted from cutaneous biopsies of 4 out of 7 patients treated with DFS during one year at doses of 1000 to 1500 mg/day were injected in mouse foot pads. Bacterial multiplication was observed in each case. The purely bacteriostatic activity of DFS for M. leprae, previously observed in mice, is thus confirmed. The eventual place of DFS in the therapy of leprosy is discussed.
D000818:Animals; D001706:Biopsy; D006801:Humans; D007917:Leprostatic Agents / Q000627:therapeutic use*; D007918:Leprosy / Q000188:drug therapy* / Q000382:microbiology; D051379:Mice; D009166:Mycobacterium leprae / Q000187:drug effects* / Q000254:growth & development; D012701:Serotonin / Q000031:analogs & derivatives* / Q000627:therapeutic use
D007917:Leprostatic Agents; D012701:Serotonin; C018901:desoxyfructo-serotonin
Activité de la désoxyfructo-sérotonine sur Mycobacterium leprae. Résultats de l'inoculation de biopsies humaines à la souris après un an de traitement.