title: Cardiovascular reactivity to methacholine in normotensives with genetic risk of hypertension.
abstract: Hemodynamic reactivity to methacholine (0,1 mg/kg bodyweight) was studied in 10 normotensives with genetic risk of hypertension (mean age: 25,4 +/- 2,6 years) in comparison with 8 controls (mean age: 25,0 +/- 2,3 yrs). Due to peripheral vasodilatation this substance led to an initial blood pressure fall which was the same in the investigated and in the control group. In the phase of counterregulation the secondary rise of blood pressure was higher in the group with family history of hypertension. As evidenced by correlation statistical analysis the increases of heart rate and cardiac output were responsible for the rise of systolic blood pressure. The hemodynamic response to methacholine in the group with genetic risk of hypertension has been attributed to a higher sympathetic reactivity.
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000235:genetics*; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000494:pharmacology*; D012306:Risk; D013315:Stress, Psychological / Q000150:complications; D013318:Stroke Volume / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects; D014655:Vascular Resistance
chemical_list: D008688:Methacholine Compounds; D016210:Methacholine Chloride