Comparative studies with extracorporeal hypothermal kidney perfusion.
Various solutions of extra- and intracellular, or non-electrolyte type supplemented with papaverine or lidocaine were administered by gravity perfusion to 60 dog kidneys. Cooling in the kidneys perfused with the solutions containing papaverine lowered the temperature of kidneys in significantly shorter time than in those containing lidocaine. The histological examinations revealed good perfusion with solutions containing papaverine; even the rim of the cortical substance has been freed of blood. Identical results could not be achieved with lidocaine. These results are to be considered in the clinical work.
D000818:Animals; D004285:Dogs; D007036:Hypothermia, Induced / Q000379:methods*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D016030:Kidney Transplantation; D008012:Lidocaine / Q000494:pharmacology; D009392:Nephrectomy; D010208:Papaverine / Q000494:pharmacology; D010477:Perfusion / Q000379:methods*; D013997:Time Factors
D008012:Lidocaine; D010208:Papaverine