title: Bifunctionality and polarized infidelity at the hisB locus of Aspergillus nidulans.
abstract: The histidine (hisB) locus of Aspergillus nidulans is unusual in two ways. Firstly, it is bifunctional; besides coding for imidazole glycerol phosphate (IGP) dehydrase, it is required for the production of ascospores (fertility). It appears, therefore, to be partly homologous to the hisB locus of Salmonella typhimurium, which codes for IGP dehydrase and histidinol phosphate phosphatase. Secondly, during meiosis it is often inaccurately transmitted to the progeny (infidelity). This phenomenon may be akin to the aberrant recombination events which cause Bar reversion in Drosophila, "selfing" in Salmonella and Neurospora, and gene fusions of the haemoglobin lepore type. A molecular model is proposed to account for the results.
mesh_terms: D000483:Alleles; D001233:Aspergillus nidulans / Q000235:genetics* / Q000528:radiation effects; D003433:Crosses, Genetic; D005800:Genes, Fungal; D005816:Genetic Complementation Test; D005838:Genotype; D006639:Histidine / Q000235:genetics*; D014466:Ultraviolet Rays
chemical_list: D006639:Histidine