Pharmacokinetics and toxicity testing.
The pharmacokinetic basis for the design of toxicity tests is discussed with reference to the absorption and clearance of drugs. The absorption and clearance of a wide range of drugs by laboratory animals and man has been examined and reviewed to provide a firm basis against which new drugs can be compared. Some pitfalls in either the empirical approach to toxicology or the incorrect interpretation of kinetic data are highlighted. An approach is outlined for the rational application of animal pharmacokinetic data in the assessment of the safety in man of a new therapeutic agent.
D000284:Administration, Oral; D000818:Animals; D001646:Bile / Q000378:metabolism; D001682:Biological Availability; D004285:Dogs; D004326:Drinking; D064420:Drug-Related Side Effects and Adverse Reactions; D004435:Eating; D005260:Female; D006207:Half-Life; D006400:Hematocrit; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007700:Kinetics; D007880:Legislation, Drug; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D013045:Species Specificity
D004364:Pharmaceutical Preparations