The mutagenicities of seven coumarin derivatives and a furan derivative (nimbolide) isolated from three medicinal plants.
Seven coumarin derivatives (imperatorin, heraclenin, xanthotoxin, marmesin, chelepin, oxypeucedanin, esculin) and a furan derivative (nimbolide) were screened on 6 Ames tester strains (TA92, TA94, TA97, TA98, TA100, TA102). The eight compounds are chemicals isolated from three Nigerian medicinal plants: Afraegle paniculata, Clausena anisata, and Azadirachta indica. Different preparations of the former are taken by Nigerians for gut disturbances, and a concoction of the latter called "Agbo" is taken as an antimalarial. Marmesin and imperatorin were mutagenic in all tester strains except TA94 and TA102. The mutagenicity potencies of marmesin and imperatorin were 20 and 0.2 respectively. Mutagenicity was highest in TA98 and TA100 in both compounds. Marmesin was optimally mutagenic at a dose of 1.04 micrograms, and imperatorin at 30.0 micrograms. Microsomal activation was not required for mutagenicity in both compounds.
D000818:Animals; D003374:Coumarins / Q000633:toxicity*; D005663:Furans / Q000633:toxicity*; D007928:Lethal Dose 50; D036701:Limonins; D009153:Mutagens; D009549:Nigeria; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects
D003374:Coumarins; D005663:Furans; D036701:Limonins; D009153:Mutagens; C042198:nimbolide