Increased IgG Fc and C3 rosette-forming capacity of granulocytes from patients with psoriasis.
In the present work the proportions of IgG Fc and C3 rosette-forming granulocytes were studied in patients with severe psoriasis. The percentages of erythrocyte-antibody and C3 rosette-forming granulocytes from psoriasis patients were significantly higher than those of healthy individuals. Sera from patients with psoriasis did not influence the rosette formation by granulocytes from healthy persons. The increased IgG Fc and C3 receptor activities of granulocytes in psoriasis may account for the hyperactivity of these cells enhancing the susceptibility of the polymorphonuclears for at least some naturally occurring stimuli.
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003176:Complement C3 / Q000276:immunology*; D005260:Female; D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D007141:Immunoglobulin Fc Fragments / Q000276:immunology*; D007128:Immunoglobulin Fragments / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000276:immunology; D012397:Rosette Formation
D003176:Complement C3; D007141:Immunoglobulin Fc Fragments; D007128:Immunoglobulin Fragments