The effects of a chronic infusion of arginine vasopressin in salt-restricted, water-deprived man.
The effects of a 48 h infusion of arginine vasopressin (AVP) were measured in five separate studies on four normal salt-restricted physicians, in whom fluid retention was prevented. The infusion was associated with an increase in renal sodium excretion which continued during the 24 h after the infusion had been discontinued. During the infusion plasma renin activity (PRA), plasma aldosterone and noradrenaline, and packed cell volume (PCV) fell; glomerular filtration rate, assessed by endogenous creatinine clearance, increased. The findings are best explained by a vasopressin-induced increase in plasma volume, which in the absence of fluid retention is likely to have been due to a redistribution of body water.
D000328:Adult; D000450:Aldosterone / Q000097:blood; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001798:Blood Proteins / Q000378:metabolism; D001810:Blood Volume / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D004039:Diet, Sodium-Restricted; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000097:blood; D011188:Potassium / Q000378:metabolism; D012083:Renin / Q000097:blood; D012964:Sodium / Q000378:metabolism; D014868:Water Deprivation / Q000502:physiology*
D001798:Blood Proteins; D001127:Arginine Vasopressin; D000450:Aldosterone; D012964:Sodium; D003404:Creatinine; D012083:Renin; D011188:Potassium; D009638:Norepinephrine