Inhibitory effect of syphilitic rabbit serum on DNA synthesis in rabbit cells in vitro.
A previously described toxic factor associated with Treponema pallidum (Nichols) and found in extracts of syphilitic rabbit testes has now also been detected in syphilitic rabbit serum. The toxic factor, which inhibits DNA synthesis in baby rabbit genital organ (BRGO) cells in vitro, is present in rabbit serum up to 30 days after infection with T pallidum.
D000818:Animals; D002478:Cells, Cultured; D003603:Cytotoxins / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis*; D005347:Fibroblasts / Q000378:metabolism; D006358:Hot Temperature; D011817:Rabbits; D013587:Syphilis / Q000276:immunology*; D013997:Time Factors; D014210:Treponema pallidum
D003603:Cytotoxins; D004247:DNA