title: Future research directions in persistent pulmonary hypertension of the newborn.
abstract: Therapy of infants with PPHN is largely supportive because the etiology and the course of the disease are variable. The authors show that continued research on the regulation of perinatal circulation and the changes that occur with ventilation will lead to more specific therapy of infants with PPHN.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D004452:Echocardiography; D004727:Endothelium / Q000473:pathology; D006801:Humans; D006976:Hypertension, Pulmonary / Q000503:physiopathology; D007231:Infant, Newborn; D008168:Lung / Q000473:pathology; D010547:Persistent Fetal Circulation Syndrome / Q000473:pathology / Q000503:physiopathology / Q000628:therapy; D011453:Prostaglandins / Q000502:physiology; D011652:Pulmonary Circulation; D051381:Rats; D012106:Research; D012121:Respiration, Artificial; D013189:SRS-A / Q000502:physiology; D012756:Sheep; D014655:Vascular Resistance; D014661:Vasoconstriction
chemical_list: D011453:Prostaglandins; D013189:SRS-A