Resistance to subcutaneous infection with Mycobacterium lepraemurium is controlled by more than one gene.
The resistance of C57BL (high) and BALB/c (low) mice, their F1 hybrids, and the offspring derived from backcrosses of the F1 to both parental strains was assessed at 20 weeks after subcutaneous infection with 10(7) Mycobacterium lepraemurium organisms. The numbers of bacilli recovered from the infected foot and draining lymph node indicated that resistance to subcutaneous infection is controlled by more than one non-H-2-linked gene of intermediate dominance. In general, female mice were more resistant than males.
D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D007113:Immunity, Innate; D008198:Lymph Nodes / Q000382:microbiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009164:Mycobacterium Infections / Q000235:genetics* / Q000382:microbiology; D009167:Mycobacterium lepraemurium; D012727:Sex Characteristics