Modulation of presynaptic gamma aminobutyric acid release by prostaglandin E2: explanation for epileptogenic activity and dysfunction in autonomic cardiac neural discharge leading to arrhythmias?
Sudden unexplained death accounts for 5-17% of deaths in the epileptic population. It has no known etiology by definition but autonomic dysfunction has been mentioned as a possible progenitor. A review of the literature was begun to ascertain a possible mechanism by which epileptogenic activity and autonomic dysfunction may be induced in these patients. Prostaglandin E2 is implicated as a possible gamma aminobutyric acid neurotransmitter inhibiting agent responsible for epileptogenic activity and autonomic dysfunction leading to arrhythmias in epileptic patients who suddenly die from unexplainable causes.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D001341:Autonomic Nervous System / Q000187:drug effects / Q000503:physiopathology; D002415:Cats; D015232:Dinoprostone; D004827:Epilepsy / Q000139:chemically induced / Q000150:complications* / Q000503:physiopathology; D006321:Heart / Q000294:innervation; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D010433:Pentylenetetrazole / Q000633:toxicity; D011458:Prostaglandins E / Q000502:physiology*; D011817:Rabbits; D051381:Rats; D013226:Status Epilepticus / Q000150:complications; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D011458:Prostaglandins E; D005680:gamma-Aminobutyric Acid; D015232:Dinoprostone; D010433:Pentylenetetrazole