Preparation of procoligenoids from Escherichia coli heat-labile enterotoxins.
Heat-labile enterotoxins from Escherichia coli strains of porcine and human origin polymerize on heating to form high-molecular-weight aggregates, "procoligenoids," analogous to procholeragenoid derived from the cholera enterotoxin. This aggregation is accompanied by loss of biological activity (toxicity). Further heating results in the release of B-subunit oligomers, coligenoids, analogous to choleragenoid. Further studies are needed to determine whether, like procholeragenoid, the procoligenoids are superior antigens in stimulating gut immunity after parenteral administration.
D000818:Animals; D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D055598:Chemical Phenomena; D002621:Chemistry; D004768:Enterotoxins; D004926:Escherichia coli / Q000276:immunology*; D029968:Escherichia coli Proteins; D006358:Hot Temperature; D006801:Humans; D008970:Molecular Weight; D011108:Polymers; D013552:Swine / Q000382:microbiology; D014121:Toxoids
D000942:Antigens, Bacterial; D001427:Bacterial Toxins; D004768:Enterotoxins; D029968:Escherichia coli Proteins; D011108:Polymers; D014121:Toxoids; C042074:procoligenoids; C027538:heat-labile enterotoxin, E coli