Sustentacular cells in the fetal human adrenal medulla are immunoreactive with antibodies to brain S-100 protein.
Adrenal glands of human fetuses were investigated by means of an immunohistochemical method with the use of an anti-S-100 serum. S-100-immunoreactivity was recognized in sustentacular cells located among the chromaffin cells. A characteristic circular arrangement of the immunostained cells was found in the central region of the adrenal glands. It surrounded aggregations of non-argyrophilic, small, round cells, which were identified as the remaining sympathoblasts (primitive sympathetic cells).
D000313:Adrenal Medulla / Q000166:cytology / Q000196:embryology / Q000276:immunology*; D000906:Antibodies / Q000276:immunology; D005260:Female; D005333:Fetus; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D011247:Pregnancy; D009418:S100 Proteins / Q000032:analysis*
D000906:Antibodies; D009418:S100 Proteins