Developmental biology of a neural cell adhesion molecule.
A membrane glycoprotein isolated from embryonic brain has been shown to be a ligand in the formation of cell-cell bonds. The molecule, called neural cell adhesion molecule (N-CAM), participates in several aspects of neural development, including the formation of plexiform layers, neurite fasciculation and nerve-muscle interactions. Experiments in vivo indicate that N-CAM-mediated adhesion is essential to the orderly assembly of the visual system.
D000818:Animals; D000954:Antigens, Surface / Q000302:isolation & purification / Q000502:physiology*; D001369:Axons / Q000502:physiology; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules; D004622:Embryo, Mammalian / Q000502:physiology; D004625:Embryo, Nonmammalian; D009132:Muscles / Q000196:embryology; D009420:Nervous System / Q000196:embryology; D009469:Neuromuscular Junction / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D012160:Retina / Q000196:embryology
D000954:Antigens, Surface; D015815:Cell Adhesion Molecules