Major histocompatibility antigens are not detectable on post-meiotic human testicular germ cells.
Neither HLA Class I nor Class II transplantation antigens were detected on human testicular germ cells by immunohistologic or immunoprecipitation techniques. This unusual characteristic of human germ-line cells could help to explain their immunologically privileged status in potentially hostile autologous and allogeneic host environments.
D000328:Adult; D000937:Antigen-Antibody Reactions; D000961:Antilymphocyte Serum; D003101:Collodion; D004591:Electrophoresis, Polyacrylamide Gel; D005455:Fluorescent Antibody Technique; D006680:HLA Antigens / Q000032:analysis* / Q000145:classification / Q000276:immunology; D006801:Humans; D008297:Male; D008540:Meiosis; D008875:Middle Aged; D011233:Precipitin Tests; D013094:Spermatozoa / Q000166:cytology* / Q000276:immunology; D013737:Testis / Q000166:cytology* / Q000276:immunology
D000961:Antilymphocyte Serum; D006680:HLA Antigens; D003101:Collodion