2-Acetylpyridine thiosemicarbazones and Mycobacterium leprae.
Four 2-acetylpyridine thiosemicarbazones were tested in mice against Mycobacterium leprae by the kinetic method and found to be nearly inactive in a dosage of 0.05% in the diet. At the same dosage, thiacetazone, as a positive control, exhibited its expected activity.
D000818:Animals; D005260:Female; D007918:Leprosy / Q000188:drug therapy*; D051379:Mice; D008815:Mice, Inbred Strains; D009166:Mycobacterium leprae; D013882:Thiosemicarbazones / Q000008:administration & dosage*
D013882:Thiosemicarbazones; C033836:2-acetylpyridine thiosemicarbazone