[Effects of locally administered corticosteroids on mineral metabolism].
The author performed a prospective study to test the mineralocorticoid activity of high doses of topically applied corticosteroids. Eight patients were treated with prednisolone eye drops. Twelve patients received fluorhydrocortisone, 9 patients triamcinolone acetonide and 11 dexamethasone; subconjunctival or parabulbar injections were used in all cases. Only the patients treated with fluorhydrocortisone showed a mineralocorticoid effect, i.e., reduced sodium excretion and a high potassium waste in the urine together with a decrease in serum potassium. Fluorhydrocortisone must not be applied topically because the risk of hypokalemia involved is so great.
D000287:Administration, Topical; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002387:Cataract Extraction; D002986:Clinical Trials as Topic; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D005438:Fludrocortisone / Q000008:administration & dosage / Q000494:pharmacology; D005938:Glucocorticoids; D006801:Humans; D008297:Male; D008903:Minerals / Q000378:metabolism*; D009883:Ophthalmic Solutions; D011188:Potassium / Q000097:blood; D011239:Prednisolone; D011897:Random Allocation; D012964:Sodium / Q000097:blood; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000494:pharmacology; D014605:Uveitis / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D008903:Minerals; D009883:Ophthalmic Solutions; D003907:Dexamethasone; D012964:Sodium; D011239:Prednisolone; D014222:Triamcinolone Acetonide; D011188:Potassium; D005438:Fludrocortisone
Der Einfluss lokal applizierter Kortikosteroide auf den Mineralhaushalt.