Enhancement of R-plasmid-determined resistance to aminoglycoside antibiotics by R-plasmid nitrofurantoin resistance in Escherichia coli.
Transfer of an R-plasmid, which confers nitrofurantoin resistance (by decreasing host strain nitrofurantoin reductase activity) to Escherichia coli K12 conferring R-plasmid aminoglycoside antibiotics resistance, increased the aminoglycoside resistance level several fold. An F' (Lac+, leu+, thr+, pro+, Gal+ Mal+) plasmid decreased the nitrofuran resistance level, annuled the increased aminoglycoside resistance and restored nitrofuran reductase activity in the transconjugants.
D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology*; D009582:Nitrofurantoin / Q000494:pharmacology*; D009601:Nitroreductases; D010088:Oxidoreductases / Q000378:metabolism*; D011815:R Factors
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D009582:Nitrofurantoin; D010088:Oxidoreductases; C029492:aromatic NADH-dependent nitroreductase; D009601:Nitroreductases