title: Dysfibrinogenemia. A current perspective.
abstract: At least 24 single amino acid substitution dysfibrinogens are currently known. Emerging evidence supports conclusions reached from studies on normal fibrinogen, which relate to the importance of release of A peptides to formation of a physiologically adequate fibrin clot; the existence of "D-D" or (b-b) polymerization sites; and the importance of the gamma chain carboxy terminal segment in fibrin assembly.
mesh_terms: D000347:Afibrinogenemia / Q000151:congenital / Q000503:physiopathology*; D000595:Amino Acid Sequence; D001777:Blood Coagulation; D005333:Fetus; D005337:Fibrin / Q000096:biosynthesis / Q000502:physiology; D005340:Fibrinogen / Q000235:genetics / Q000502:physiology; D014644:Genetic Variation; D006801:Humans; D013997:Time Factors
chemical_list: D005337:Fibrin; D005340:Fibrinogen