title: Laser treatment of keloids: a clinical trial and an in vitro study with Nd:YAG laser.
abstract: Biochemical studies utilizing keloid fibroblast cultures revealed that Nd:YAG laser selectively suppressed collagen production by these cells. Based on these in vitro observations, eight patients with keloids were treated with Nd:YAG laser in a nondestructive manner. Results, with a 3-year follow-up, indicated flattening and softening of the lesions. Thus, the results suggest that Nd:YAG laser is an effective treatment modality for keloids, and its mechanism may involve bioinhibition of fibroblast functions.
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D002986:Clinical Trials as Topic; D003094:Collagen / Q000096:biosynthesis; D005260:Female; D005347:Fibroblasts / Q000378:metabolism / Q000528:radiation effects; D005500:Follow-Up Studies; D006801:Humans; D007627:Keloid / Q000378:metabolism / Q000601:surgery*; D053685:Laser Therapy; D009354:Neodymium; D015019:Yttrium
chemical_list: D009354:Neodymium; D015019:Yttrium; D003094:Collagen