[Recombinant haplotype H-2 in mice of the congenic resistant strain B10.D1(R108)/Y].
Recombinant H-2 haplotype of mouse strain B10.D1(R108)/Y (symbol R108) obtained in experiments with skin grafting in the course of developing the CR B10.D1/Y strain (strain DBA/LacY--the donor of H-2q) was studied. Strains with recombinant H-2 haplotypes a, h2, g1, i3, i5, i7, m, y1 were used. Alleles of different H-2 (K, I, D) regions were determined according to the presence or absence of genetic complementation in the F1 test with skin grafts. R108 recombinant was studied by serological methods with panel of anti-H-2 sera. Anti-H-2Kb (H-2.33) and anti-H-2Dq (H-2.30) monospecific antisera were used in microcytotoxicity test and in absorption experiments in vitro. It was concluded that crossing over between H-2b and H-2q chromosomes, which led to formation of recombinant H-2 haplotype of R108 mice, occurred at I region, between IA and IC subregions. The H-2 complex of R108 line has KbIAbIJ?IE?ICqSqDq alleles. bq1 symbol was proposed for the H-2 haplotype of B10.D1(R108)/Y strain.
D000483:Alleles; D000818:Animals; D003434:Crossing Over, Genetic; D003601:Cytotoxicity Tests, Immunologic; D005816:Genetic Complementation Test; D005838:Genotype; D006183:H-2 Antigens / Q000235:genetics*; D006238:Haploidy; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains / Q000235:genetics*; D011995:Recombination, Genetic; D016038:Skin Transplantation
D006183:H-2 Antigens
Izuchenie rekombinantnogo gaplotipa H-2 mysheĭ kongenno-rezistentnoĭ linii B10.D1(R108)/Y.