title: [Comparative study of the immunogenicity of neurotoxin preparations and their separate fractions obtained from Shigella sonnei, phases I and II].
abstract: The immunogenicity of the preparations of phase I S. sonnei neurotoxin, determined by the keratoconjunctival test on guinea pigs, is linked mainly with the presence of a high-molecular component other than endotoxin in these preparations. The preparations of phase II S. sonnei neurotoxin do not contain the endotoxin and high-molecular antigens of S. sonnei, phase I, which protect guinea pigs from the development of experimental keratoconjunctivitis; these preparations are toxic for mice and possess low immunogenicity.
mesh_terms: D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D004731:Endotoxins / Q000276:immunology* / Q000302:isolation & purification; D006168:Guinea Pigs; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D007114:Immunization; D051379:Mice; D009498:Neurotoxins / Q000276:immunology* / Q000302:isolation & purification; D012764:Shigella sonnei / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity; D013997:Time Factors; D014774:Virulence
chemical_list: D004731:Endotoxins; D009498:Neurotoxins
vernacular_title: Sravnitel'noe issledovanie immunogennosti preparatov neĭrotoksinov i ikh otdel'nykh fraktsiĭ, poluchennykh iz Shigella sonnei I i II faz.