Dermatological aspects of the use of Cyclosporin A for prophylaxis of graft-versus-host disease.
Oral Cyclosporin A (CyA) was given for the prophylaxis of graft-versus-host disease (GVHD) to sixty-seven patients receiving a bone marrow transplant, and was found to be extremely effective in reducing the severity of acute GVHD. Side-effects of CyA included hypertrichosis, gum hypertrophy, and a rare but serious 'capillary leak' syndrome.
D000328:Adult; D016026:Bone Marrow Transplantation; D002199:Capillary Permeability / Q000187:drug effects; D002648:Child; D003524:Cyclosporins / Q000009:adverse effects / Q000627:therapeutic use*; D006086:Graft vs Host Disease / Q000517:prevention & control*; D006801:Humans; D006983:Hypertrichosis / Q000139:chemically induced; D007668:Kidney / Q000187:drug effects; D008297:Male; D011565:Psoriasis / Q000188:drug therapy; D012751:Sezary Syndrome / Q000188:drug therapy
D003524:Cyclosporins