[Prevention of infected urinary stones by urease inhibitor. IV. Treatment of infection stones in rats by a new hydroxamic acid and cefalexin].
We investigated the combined effectiveness of a new urease inhibitor, N-( pivaroyl ) glycinohydroxamic acid, with Cefalexin in the treatment of infection stones in rats. Combination therapy with the hydroxamic acid and Cefalexin inhibited bladder stone formation, and dissolved the stone dose dependently, while separate therapy was not significantly effective against stone formation or bacterial growth. This compound may become a useful medicine for the treatment of infection stones.
D000818:Animals; D002506:Cephalexin / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D006877:Hydroxamic Acids / Q000627:therapeutic use*; D008297:Male; D011512:Proteus Infections / Q000150:complications / Q000188:drug therapy; D011513:Proteus mirabilis; D051381:Rats; D014510:Urease / Q000037:antagonists & inhibitors*; D001744:Urinary Bladder Calculi / Q000188:drug therapy* / Q000209:etiology / Q000517:prevention & control; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy*
D006877:Hydroxamic Acids; C032346:N-(pivaloyl)glycinohydroxamic acid; D014510:Urease; D002506:Cephalexin