Glucocorticoid receptors: from development to aging. A review.
Glucocorticoid responses are known to be altered during development and aging in many tissues. Therefore, in the past several years considerable attention has been given to determining if glucocorticoid receptors are altered with age. In this review, studies concerning glucocorticoid receptor ontogenic and age-dependent changes in number, affinity and physicochemical properties are summarized. In addition, possible mechanisms of age-related changes in the receptor are discussed along with future goals and approaches which may be of great importance in this area of research.
D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism; D002642:Chick Embryo; D003600:Cytosol / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism; D051379:Mice; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*
D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid