title: Adverse reactions to monoamine oxidase inhibitors. Part I. A comparative study.
abstract: The incidence of major side effects of phenelzine and tranylcypromine is compared with that of imipramine and placebo medication in depressed outpatients. Psychiatric notes in the charts of 198 patients were reviewed. Based on clinical experience and literature review, 14 side effects were selected for study because of serious medical risk or subjective discomfort great enough to require drug discontinuation. Significant differences in risk for major side effects, as well as distinctive side effect profiles for each drug, were found. More side effects occurred on phenelzine, but these tended not to lead to drug discontinuation more often than with tranylcypromine, nor were they accounted for by differences in age, sex, diagnosis, or duration of treatment.
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007099:Imipramine / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000009:adverse effects* / Q000627:therapeutic use; D010624:Phenelzine / Q000009:adverse effects; D011897:Random Allocation; D012737:Sex Factors; D014191:Tranylcypromine / Q000009:adverse effects
chemical_list: D008996:Monoamine Oxidase Inhibitors; D014191:Tranylcypromine; D010624:Phenelzine; D007099:Imipramine