[The IgM enzyme immuno-screening test for congenital rubella].
A commercially available rubella-IgM-enzyme immunological assay (Enzygnost, Behringwerke) was used to test 20 000 samples for rubella-specific IgM antibodies. Examination of dry-blood samples on filter paper avoided any false-positive or doubtful readings. In five children congenital rubella infection was detected by definitely positive test results. In three first clinical examination was unremarkable, two had cardiac and other abnormalities. Two of the children were of mothers in whom positive results of serological screening for rubella had been misinterpreted as sufficient protection against rubella. These results favour the inclusion of IgM-specific tests in a screening programme. Because of possible late sequelae of the infection, symptom-poor children should be carefully examined and followed for several years.
D005260:Female; D006385:Hemagglutination Inhibition Tests; D006801:Humans; D007124:Immunoenzyme Techniques; D007075:Immunoglobulin M / Q000032:analysis; D007231:Infant, Newborn; D008297:Male; D011933:Reagent Kits, Diagnostic; D012409:Rubella / Q000151:congenital* / Q000175:diagnosis
D007075:Immunoglobulin M; D011933:Reagent Kits, Diagnostic
IgM-Enzym-Immuno-Screeningtest auf konnatale Röteln.