Major histocompatibility complex restriction and transplantation immunity. A possible solution to the allograft problem.
Studies of the survival of weakly histoincompatible skin grafts in which the Langerhans' cells (LC)5 have been replaced with major histocompatibility complex (MHC)-compatible or incompatible LC, as well as studies of the fate of cultured endocrine allografts in MHC-compatible and incompatible mice and rats, indicate that allografts are only recognized as foreign if they possess donor macrophages (or cells of this family), or if antigen presenting cells MHC-compatible with the graft can be provided by the host.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D002678:Chimera; D004702:Endocrine Glands / Q000637:transplantation; D005260:Female; D006085:Graft Survival; D006182:H-Y Antigen / Q000276:immunology; D016027:Heart Transplantation; D006649:Histocompatibility Antigens / Q000276:immunology; D007801:Langerhans Cells / Q000276:immunology; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D009924:Organ Culture Techniques; D051381:Rats; D012737:Sex Factors; D012867:Skin / Q000276:immunology; D016038:Skin Transplantation; D014181:Transplantation Immunology
D006182:H-Y Antigen; D006649:Histocompatibility Antigens