Glucagon antibodies alter Langerhans' islets.
The passive transfer of rabbit anti-glucagon antibodies into mice induces periinsular and intrainsular inflammation and hyperplasia of alpha cells. Active immunization of rabbits with heterologous glucagon induces alpha cell hyperplasia.
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D005934:Glucagon / Q000276:immunology*; D007114:Immunization; D007116:Immunization, Passive; D007515:Islets of Langerhans / Q000276:immunology* / Q000473:pathology; D051379:Mice; D011817:Rabbits
D000906:Antibodies; D005934:Glucagon