Neuraminidase production by Candida albicans.
A Candida albicans strain G42, isolated from a vaginal infection, was demonstrated to produce neuraminidase in culture filtrates with activity for N-acyl-neuraminic acid glycoprotein from bovine submaxillary gland, and human erythrocytes as substrates. Incubation of viable cells from G42 with human group O Rh(+) erythrocytes released N-acetyl-neuraminic acid in a time-dependent manner. Thirty-two clinical isolates of C albicans were studied for neuraminidase production. Enzyme activity was found in culture filtrates from five strains.It would appear important from these data to determine whether the production of neuraminidase by C albicans can be correlated with pathogenicity.
D000818:Animals; D002176:Candida albicans / Q000378:metabolism*; D002417:Cattle; D004912:Erythrocytes / Q000201:enzymology; D006386:Hemagglutination Tests; D006801:Humans; D009439:Neuraminidase / Q000096:biosynthesis*; D012794:Sialic Acids / Q000378:metabolism; D012795:Sialoglycoproteins / Q000378:metabolism
D012794:Sialic Acids; D012795:Sialoglycoproteins; D009439:Neuraminidase