Action of certain pharmacological associations on the level of cerebral biogenic amines and some metabolites in the curative treatment of hemorrhagic shock in rats.
Different associations of pharmacological agents were tested in the curative treatment of hemorrhagic shock, using as criteria the variations of cerebral biogenic amines (NE, DA, 5-HT) and some of their metabolites (DOPAC, HVA, 5-HIAA). These values were compared to those observed in controls two hours after the reinjection of effused blood. Prior work had led to the use of each component of these therapeutic associations and the reasons having suggested their association are summarized. The results show that the most active association for antagonizing the changes of the above amines and metabolites is that of tyrosine, 15% glucose, insulin and vitamin C. The results are discussed.
D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001679:Biogenic Amines / Q000378:metabolism*; D001784:Blood Gas Analysis; D001786:Blood Glucose / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects*; D005947:Glucose / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D008297:Male; D011724:Pyridazines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012771:Shock, Hemorrhagic / Q000188:drug therapy*
D001679:Biogenic Amines; D001786:Blood Glucose; D007328:Insulin; D011724:Pyridazines; C006149:minaprine; D005947:Glucose; D000241:Adenosine; D001205:Ascorbic Acid