[Effect of thyroxine in the G0 stage of the cell cycle on the yield of chromosome aberrations in rat hepatocytes and human lymphocytes after X-irradiation].
A study was made of the mechanism of a modifying action of thyroxin (T4) on the chromosome integrity after the application thereof in vivo and in vitro following a single whole-body exposure to X-radiation with a dose of 2.19 Gy. It is concluded that T4 influences the quantity of cells with chromosome aberrations stimulating the recovery of the chromosome integrity: the stimulation can be brought about at the G0 stage of the cell cycle as a result of the direct effect of the hormone on a cell.
D000818:Animals; D002869:Chromosome Aberrations; D006801:Humans; D007399:Interphase / Q000528:radiation effects*; D008099:Liver / Q000166:cytology / Q000528:radiation effects*; D008214:Lymphocytes / Q000528:radiation effects*; D008297:Male; D008938:Mitosis; D051381:Rats; D013974:Thyroxine / Q000494:pharmacology*; D014916:Whole-Body Irradiation
D013974:Thyroxine
Vliianie tiroksina v stadii G0 kletochnogo tsikla na vykhod aberratsiĭ khromosom v gepatotsitakh krys i limfotsitakh cheloveka posle rentgenovskogo oblucheniia.