Renin-aldosterone axis in ethanol intoxication: effect of an ADH analogue (desaminocys1-D-arg8-vasopressin, DDAVP).
Plasma renin activity (PRA) is stimulated and renin-aldosterone nexus is broken in acute ethanol intoxication. Serial changes in renin-aldosterone axis were studied in five healthy males during moderate ethanol intoxication, while alcohol diuresis was prevented by 20 micrograms of an antidiuretic hormone analogue, desaminocys1-D-arg8-vasopressin (DDAVP), administered intranasally. The experiment was performed with the subject supine, and the amount of ethanol taken p.o., at a steady rate in 90 min, was 1.2 g/kg body weight, diluted with juice to 20 vol% solution. DDAVP prevented the stimulation of PRA, suggesting that dehydration due to alcohol diuresis is the main reason for this phenomenon during ethanol intoxication. However, there still was a dissociation between PRA and aldosterone, which may be caused by increased serum Na+/K+ ratio or an inhibitory action of ethanol on aldosterone secretion.
D000328:Adult; D000435:Alcoholic Intoxication / Q000097:blood* / Q000503:physiopathology; D000450:Aldosterone / Q000097:blood; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D011188:Potassium / Q000097:blood; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System / Q000187:drug effects*; D012964:Sodium / Q000097:blood
D001127:Arginine Vasopressin; D000450:Aldosterone; D012964:Sodium; D012083:Renin; D003894:Deamino Arginine Vasopressin; D011188:Potassium