Antimicrobial effects of a macrophage-derived cytotoxin from the serum of BCG-primed rabbits (tumour necrosis serum).
Previous studies have shown that a macrophage-derived cytotoxin, found in high titre in the serum of BCG-primed rabbits, killed malarial parasites and certain tumour cells. In this study, the macrophage cytotoxin was tested for activity against microorganisms other than protozoa. No activity was seen against a range of gram-negative or gram-positive bacteria or against Candida albicans. It is concluded that the macrophage cytotoxin has limited anti-microbial activity, perhaps restricted to certain intra-cellular parasites.
D000818:Animals; D001500:BCG Vaccine / Q000378:metabolism*; D002176:Candida albicans / Q000187:drug effects*; D002460:Cell Line; D003603:Cytotoxins / Q000494:pharmacology*; D006023:Glycoproteins / Q000494:pharmacology*; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D006131:Growth Inhibitors / Q000494:pharmacology*; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D009369:Neoplasms / Q000097:blood; D011817:Rabbits; D014409:Tumor Necrosis Factor-alpha
D001500:BCG Vaccine; D003603:Cytotoxins; D006023:Glycoproteins; D006131:Growth Inhibitors; D014409:Tumor Necrosis Factor-alpha