Plasma exchanges in frequently recurrent hemolytic-uremic syndrome in a child.
22 plasma exchanges (PE) were carried out on a 9 year old boy with frequently recurrent hemolytic-uremic syndrome (HUS) and persistently low plasma factor which normally stimulates vascular prostacyclin (PGI2) release. The factor was partially restored after PE but declined within 2-4 weeks. No major recurrence of HUS occurred, but "minor" attacks recurred despite PE. It is likely that a genetic predisposition is responsible for the recurrences of HUS, but the ultimate relationship between recurrent HUS and persistent plasma deficiency for PGI2-release remains to be defined.
D011464:Epoprostenol / Q000097:blood; D006463:Hemolytic-Uremic Syndrome / Q000097:blood / Q000628:therapy*; D006801:Humans; D007223:Infant; D008297:Male; D010949:Plasma / Q000032:analysis; D010951:Plasma Exchange; D012008:Recurrence
D011464:Epoprostenol