Involvement of dietary nucleotides in T lymphocyte function.
The data described above show clearly that absence of a dietary source of preformed purine or pyrimidine bases suppress T lymphocyte function. The heart allograft model assesses the T lymphocyte response to allografts. The SRBC sensitization assay indicates the activity of T effector cells is involved in delayed hypersensitivity. The mitogen assays clearly indicate a dietary effect on in vitro T cell response. The effect of dietary nucleotides on immune function should be of great importance in a number of clinical situations. These include management of organ transplant patients, in recovery from malnutrition, in various chemotherapeutic regimens and in treatment of T cell derived leukemias.
D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D005260:Female; D016027:Heart Transplantation; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D009711:Nucleotides / Q000494:pharmacology*; D010835:Phytohemagglutinins; D012331:RNA, Fungal / Q000494:pharmacology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D014184:Transplantation, Homologous
D009711:Nucleotides; D010835:Phytohemagglutinins; D012331:RNA, Fungal