title: Bone structure, composition, and mineralization.
abstract: Bone structure and function are dependent on complex interactions between cells, matrix, cell-derived factors, and systemic factors. The deposition of mineral in bone, which enables the skeleton to function properly, is described as a four-step process of matrix modification, crystal nucleation, crystal growth, and remodeling. Insight into the function of bone components in the mineralization process is provided by in vitro studies and analysis of abnormal calcifications.
mesh_terms: D000818:Animals; D001846:Bone Development; D001857:Bone Matrix / Q000378:metabolism; D019485:Bone Morphogenetic Proteins; D001862:Bone Resorption; D001842:Bone and Bones / Q000033:anatomy & histology* / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D006133:Growth Substances / Q000378:metabolism; D006801:Humans; D006882:Hydroxyapatites / Q000378:metabolism; D008854:Microscopy, Electron; D008903:Minerals / Q000378:metabolism*; D010006:Osteoblasts / Q000648:ultrastructure; D015675:Osteocalcin; D010010:Osteoclasts / Q000648:ultrastructure; D010011:Osteocytes / Q000648:ultrastructure; D010012:Osteogenesis; D010750:Phosphoproteins / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011510:Proteolipids / Q000378:metabolism
chemical_list: D019485:Bone Morphogenetic Proteins; D002135:Calcium-Binding Proteins; D006133:Growth Substances; D006882:Hydroxyapatites; D008903:Minerals; D010750:Phosphoproteins; D011506:Proteins; D011510:Proteolipids; D015675:Osteocalcin; D003094:Collagen