[Correlation of the mutagenic and carcinogenic activity of various aromatic amines].
Six aromatic amines were studied for their mutagenic activity using Salmonella typhimurium TA 100 and TA 98. 3,3'-dichlorobenzidine, ortho-tolidine, benzidine, 2-naphthylamine proved to be mutagenic, while aminotobias acid and 2,2',4,4'-tetraaminodiphenyl did not show mutagenic activity. Chronic experiments on mice and rats using these compounds revealed a close correlation between carcinogenicity and mutagenicity.
D015081:2-Naphthylamine / Q000633:toxicity*; D000814:Aniline Compounds / Q000633:toxicity*; D000818:Animals; D001560:Benzidines / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D009152:Mutagenicity Tests; D009153:Mutagens; D009281:Naphthalenes / Q000633:toxicity*; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics
D000814:Aniline Compounds; D001560:Benzidines; D009153:Mutagens; D009281:Naphthalenes; D015081:2-Naphthylamine
Korreliatsiia mutagennoĭ i kantserogennoĭ aktivnosti nekotorykh aromaticheskikh aminov.