Acute disseminated histiocytosis-X: in situ immunophenotyping with monoclonal antibodies.
The proliferating skin cells in a case of acute disseminated histiocytosis-X (Abt-Letterer-Siwe disease) confirmed by electron microscopy, were characterized by a panel of monoclonal antibodies using an immunoperoxidase technique. The "histiocytes" were found to stain with OKT-6 (anti-T6) and anti-HLA-DR antibodies. Unexpectedly, slight staining was also observed with Leu 3a (anti-T4) and OKM-1. A proliferative process of T4, T6, HLA-DR, OKM-1 positive Langerhans' cells has not yet been described and may be specific for histiocytosis-X.
D000911:Antibodies, Monoclonal; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000151:congenital / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007121:Immunocompetence; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D007801:Langerhans Cells / Q000276:immunology; D012867:Skin / Q000276:immunology* / Q000648:ultrastructure
D000911:Antibodies, Monoclonal