Stimulation of renin release from rat renal cortical slices by cyclosporin A.
Cyclosporin A is known to produce increases in plasma and kidney renin in vivo. In this study, Cyclosporin A was shown to stimulate renin release in vitro in rat renal cortical slices. At the optimal concentration of 8 x 10(-6) M Cyclosporin A, renin release was stimulated by up to 43% during a 2 hr incubation at 37 degrees. This observation strengthens the hypothesis that the intra renal renin-angiotensin system may participate in the mechanism of Cyclosporin A nephrotoxicity.
D000818:Animals; D003524:Cyclosporins / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000378:metabolism*; D013997:Time Factors
D003524:Cyclosporins; D012083:Renin