Vertebral hyperemia associated with bone marrow insult and recovery.
A 15-year-old boy with rhabdoid sarcoma received chemotherapy, which was followed by bone marrow depression, massive nosebleeds and, finally, hematologic recovery. On both hepatobiliary and renal scintigraphy, prominent vertebral activity was present in early images. Correlation with his clinical course suggests that the findings reflect hyperemia due to marrow insult and recovery. Radionuclide imaging to detect hyperemia may be a useful probe for drug effects on hematopoietic bone marrow.
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001853:Bone Marrow / Q000187:drug effects*; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D004844:Epistaxis / Q000139:chemically induced; D006801:Humans; D006940:Hyperemia / Q000139:chemically induced / Q000000981:diagnostic imaging*; D007098:Imino Acids; D008297:Male; D004369:Pentetic Acid; D011877:Radionuclide Imaging; D012208:Rhabdomyosarcoma / Q000188:drug therapy*; D013131:Spine / Q000098:blood supply*; D013667:Technetium; D019785:Technetium Tc 99m Disofenin; D016284:Technetium Tc 99m Pentetate; D013899:Thoracic Neoplasms / Q000188:drug therapy*; D013921:Thrombocytopenia / Q000139:chemically induced; D014750:Vincristine / Q000008:administration & dosage
D007098:Imino Acids; D003609:Dactinomycin; D014750:Vincristine; D013667:Technetium; D004369:Pentetic Acid; D003520:Cyclophosphamide; D019785:Technetium Tc 99m Disofenin; D016284:Technetium Tc 99m Pentetate