Colicine production and colicine sensitivity typing of nephropathogenic serotypes of Escherichia coli.
Usefulness of colicine sensitivity typing and colicine production typing methods of E. coli strains from UTI was different. Colicine sensitivity typing appeared to be useless because of too high proportion of different types and low reproducibility of results. The advantage of the colicinogenotyping was the possibility of conducting more detailed analysis of strains belonging to one serotype as well as of differentiating a part of NT and Aut strains. Reduction of Abbott-Shannon's set to 6 indicator strains did not limit the practical value of the set for differentiation of E. coli strains. The great number of different colicinogenic types among strains belonging to serotype 06 pointed to nonhomogenecity of this serotype. The colicinogenic pattern 2 being more frequent in UTI was colicine V producer in 93,2%. Serotype 06 and 075 were colicine V producers in smaller percentages than other NPG and NT strains. In the light of our investigations it seems that correlation between the resistance of E. coli to colicines, colicine production and pathogenicity was doubtful.
D003087:Colicins / Q000096:biosynthesis* / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000145:classification* / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D014552:Urinary Tract Infections / Q000382:microbiology*
D003087:Colicins