Cyclosporin-associated central nervous system toxicity after allogeneic bone marrow transplantation.
Five of 64 recipients of HLA-identical sibling marrow allografts who were given cyclosporin (CSP) to minimize graft-versus-host disease posttransplant had a serious neurological illness thought to be due to CSP. Characteristic clinical features included a motor spinal cord syndrome, a cerebellar-like syndrome, and mental confusion. All five recovered when the CSP dose was reduced or the drug was stopped.
D058186:Acute Kidney Injury / Q000139:chemically induced; D000328:Adult; D001259:Ataxia / Q000139:chemically induced; D016026:Bone Marrow Transplantation; D002493:Central Nervous System Diseases / Q000139:chemically induced*; D003221:Confusion / Q000139:chemically induced; D003524:Cyclosporins / Q000627:therapeutic use / Q000633:toxicity*; D005260:Female; D006086:Graft vs Host Disease / Q000517:prevention & control; D006801:Humans; D007951:Leukemia, Myeloid / Q000628:therapy; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced; D008875:Middle Aged; D011712:Pyramidal Tracts / Q000187:drug effects; D014202:Tremor / Q000139:chemically induced
D003524:Cyclosporins