[Effect of different saluretics on carbohydrate metabolism and blood pressure behavior in diabetics].
Authors checked values of the blood pressure as well as in 23 hypertensive diabetic patients during the antihypertensive therapy with hydrochlorothiazide (Spofa) and acetazolamide (Diluran Spofa) and compared it with values gained before the therapy was started. After a preceeding period patients received both remedies over a period of 9 weeks each, the sequence of the remedies being effected in two groups of twelve and eleven patients each. There were not found any differences in the glycaemia values during the follow up study. Blood pressure has been lowered after both diuretics but has even more diminished after the hydrochlorothiazide. We conclude that the use of small doses of thiazides in the treatment of high blood pressure can also recommended for diabetics, if by correct checking of the potassium values possible negative metabolic consequences can be avoided from the first.
D000086:Acetazolamide / Q000627:therapeutic use; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects*; D050260:Carbohydrate Metabolism; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000503:physiopathology; D004232:Diuretics / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006029:Glycosuria / Q000652:urine; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D004232:Diuretics; D006852:Hydrochlorothiazide; D000086:Acetazolamide
Die Wirkung verschiedener Saluretika auf den Kohlenhydratstoffwechsel und das Blutdruckverhalten bei Diabetikern.