title: Glucose 6-phosphate effects on deoxyglucose, glucose and methylglucose transport in rat adipocytes. Evidence for intracellular regulation of sugar transport by glucose metabolites.
abstract: This study was undertaken to determine whether glucose 6-phosphate can modulate hexose transport in rat adipocytes. The data demonstrated that glucose 6-phosphate decreased hexose transport rates in adipocytes and in adipose plasma membrane vesicles. This effect was not via competitive inhibition. The data provide direct evidence that hexose transport can be inhibited noncompetitively by glucose 6-phosphate.
mesh_terms: D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003847:Deoxyglucose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D005958:Glucosephosphates / Q000494:pharmacology*; D007328:Insulin / Q000494:pharmacology; D007700:Kinetics; D008757:Methylglucosides / Q000378:metabolism; D051381:Rats
chemical_list: D005958:Glucosephosphates; D007328:Insulin; D008757:Methylglucosides; D003847:Deoxyglucose; D005947:Glucose