[A double-blind study of the effect of L-dopa in psychotic patients with tardive dyskinesia].
Appropriate manipulation of dopaminergic systems, that probably contribute to tardive dyskinesia, may bring about a reduction in its intensity. In this study various, increasing doses of L-dopa, which is converted to dopamine in the CNS, was administered over the relatively long period of time of one month, in double-blind conditions, to psychiatric patients with stabilized psychotic symptoms, with tardive dyskinesia. With the one gram daily dose group, there was a reduction of the intensity of the involuntary movements, when compared to that of the patients who received placebo.
D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010919:Placebos; D011618:Psychotic Disorders / Q000188:drug therapy / Q000503:physiopathology*
D010919:Placebos; D007980:Levodopa
Estudo duplo-cego sobre a ação de L-dopa em pacientes psicóticos com discinesia tardia.