Radioimmunodetection and radioimmunotherapy.
The development of monoclonal antibodies that recognize tumor-associated antigens has led to significantly greater practical possibilities for producing highly specific radiolabeled antibodies for diagnosis and therapy of human tumors. A number of problems remain before this technique will be ready for routine clinical application however. Achieving the high target to background ratio that are predicted on theoretical grounds is a major challenge in cancer investigation.
D000911:Antibodies, Monoclonal / Q000627:therapeutic use; D000915:Antibody Affinity; D000918:Antibody Specificity; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D007167:Immunotherapy; D007553:Isotope Labeling; D008545:Melanoma / Q000175:diagnosis / Q000628:therapy; D008970:Molecular Weight; D009369:Neoplasms / Q000175:diagnosis / Q000628:therapy*; D011786:Quality Control; D011863:Radioimmunoassay; D011868:Radioisotopes; D014057:Tomography, X-Ray Computed
D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D011868:Radioisotopes