[Morphofunctional characteristics of the initial phase of the development of experimental diabetes mellitus].
In experiments on albino rats it was found that the partial alloxan elimination of the pancreatic incretory elements followed by the normal diet and long-term adaptation of a healthy organism to excessive readily assimilating food carbohydrates are accompanied by a series of morphofunctional shifts, indicating the development of early diabetes mellitus stages, which are characterized by a recurrent increase in the glycemia level over 100 mg/100 ml, in the presence of sugar curves, changed according to a questionable type, hyperinsulinism and hyperlipemia arising. Some pancreatic islets are hypertrophied, whereas their beta-cell number decreases.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000209:etiology / Q000503:physiopathology*; D005951:Glucose Tolerance Test; D007515:Islets of Langerhans / Q000473:pathology; D008055:Lipids / Q000097:blood; D011236:Prediabetic State / Q000209:etiology / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001786:Blood Glucose; D008055:Lipids
Morfofunktsional'naia kharakteristika nachal'noĭ fazy razvitiia éksperimental'nogo sakharnogo diabeta.