Immunolocalization of collagen types, laminin and fibronectin in the normal human pancreas.
In order to define the connective matrix organization of the normal human pancreas collagen types I, III, pro-III and IV, laminin and fibronectin were labeled using specific, antihuman antibodies. Visualization was by indirect immunofluorescence. Collagen types I, III and pro-III were present within lobules: around acini, ducts and small vessels. Their immunofluorescence reaction was particularly obvious in septa and it also outlined interlobular vessels and ducts. The type III and pro-III fractions possessed a characteristic, branched appearance in many situations, when compared to the more linear type I reaction. Collagen type IV, laminin and fibronectin were closely applied to acini, ducts and vessels, but in contrast to the other collagen types were absent from septa.
D000906:Antibodies; D003094:Collagen / Q000276:immunology*; D003238:Connective Tissue / Q000276:immunology; D005353:Fibronectins / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007797:Laminin / Q000276:immunology*; D010179:Pancreas / Q000276:immunology*; D011347:Procollagen / Q000276:immunology
D000906:Antibodies; D005353:Fibronectins; D007797:Laminin; D011347:Procollagen; D003094:Collagen