Intra-articular radioactive yttrium and triamcinolone hexacetonide: an inconclusive trial. Arthritis and Rheumatism Council Multicentre Radiosynoviorthesis Trial Group.
A restricted sequential design multicentre controlled trial of yttrium-90 against triamcinolone intra-articularly was undertaken in patients with rheumatoid arthritis with knee involvement. The trial had to be discontinued because of dwindling recruitment over time. The reasons for this and other features contributing to an inconclusive outcome are noted. This experience lends little encouragement to the idea that yttrium-90 therapy is more or less advantageous than triamcinolone hexacetonide.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D006801:Humans; D007719:Knee Joint; D017640:Silicates; D014222:Triamcinolone Acetonide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D015019:Yttrium; D015021:Yttrium Radioisotopes / Q000627:therapeutic use*
D017640:Silicates; D015021:Yttrium Radioisotopes; C028301:yttrium silicate; D015019:Yttrium; D014222:Triamcinolone Acetonide; C005900:triamcinolone hexacetonide