[Lipoprotein lipase].
Functional LPL is located on the membrane of the endothelial cells which line the capillaries, in direct contact with circulating blood. By means of LPL, the tg contained in VLDL and plasma chylomicrons are hydrolysed. The fatty acids released by this hydrolysis can then be taken up, for oxidative use or for storage (such as adipocytes which store these fatty acids in the form of tg. A deficiency of LPL or of an LPL activator (such as apo CII) or the presence of in vivo inhibitors of LPL obviously results in a hypertriglyceridaemia. These cases are nevertheless relatively rare.
D000818:Animals; D001161:Arteriosclerosis / Q000201:enzymology; D055598:Chemical Phenomena; D002621:Chemistry; D002914:Chylomicrons / Q000378:metabolism; D006728:Hormones / Q000502:physiology; D006801:Humans; D008071:Lipoprotein Lipase / Q000096:biosynthesis / Q000378:metabolism* / Q000502:physiology; D008079:Lipoproteins, VLDL / Q000378:metabolism; D009747:Nutritional Physiological Phenomena; D009765:Obesity / Q000201:enzymology
D002914:Chylomicrons; D006728:Hormones; D008079:Lipoproteins, VLDL; D008071:Lipoprotein Lipase
La lipoprotéine lipase.