Emphysema induced by intravenously administered endotoxin in an alpha 1-antitrypsin-deficient rat model.
The effect of repeated intravenous injections of Escherichia coli endotoxin on lung structure and lung parenchymal elastin proportions was studied in rats rendered deficient in alpha 1-antitrypsin by administration of galactosamine. Within 24 h after endotoxin administration, polymorphonuclear leukocyte sequestration was demonstrable by microscopy and differential cell counts of pulmonary lavage fluid. Measurement of the proportions of elastin in lung parenchyma at 24 h revealed values in the normal range; 10 wk after repeated galactosamine and endotoxin administration, there was a reduction in the proportions of lung parenchymal elastin. At 10 wk, these animals showed a significant increase in the mean linear intercept and pulmonary compliance. Animals treated with endotoxin alone developed some but not all of the changes seen in the animals deficient in alpha 1-antitrypsin.
D000818:Animals; D004549:Elastin / Q000032:analysis; D004731:Endotoxins / Q000008:administration & dosage*; D004926:Escherichia coli; D005260:Female; D005688:Galactosamine / Q000494:pharmacology; D007275:Injections, Intravenous; D008168:Lung / Q000032:analysis / Q000473:pathology; D008170:Lung Compliance / Q000187:drug effects; D011656:Pulmonary Emphysema / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D019896:alpha 1-Antitrypsin Deficiency
D004731:Endotoxins; D005688:Galactosamine; D004549:Elastin