[Changes in the homeostatic balance of prostacyclin-thromboxane generating systems during experimental social stress].
Chronic emotional stress leads to the reduction in prostacycline content in the vascular wall and to the elevation of the malonic aldehyde level in the platelets, with a simultaneous increase of the spontaneous platelet aggregation index. Antistressor and antiaggregation action of the adaptation to high mountains occurs at later times (day 30) in both normal and stress-exposed rats despite the fact that stress-exposed rats yield to normal ones as regards the magnitude of prostacycline activation in the vascular wall. This is accounted for by initial (before adaptation) stress-induced disturbance of the balance between prostacycline and thromboxan.
D000064:Acclimatization; D000531:Altitude; D000818:Animals; D001011:Aorta / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism*; D011464:Epoprostenol / Q000096:biosynthesis*; D006706:Homeostasis; D006801:Humans; D051381:Rats; D012934:Social Isolation; D013315:Stress, Psychological / Q000378:metabolism*; D013931:Thromboxanes / Q000097:blood*
D013931:Thromboxanes; D011464:Epoprostenol
Izmenenie gomeostaticheskogo balansa prostatsiklin-tromboksangeneriruiushchikh sistem pri zoosotsial'nom stresse.