Genotoxicity of the free-radical producers CCl4 and lipoperoxide in Aspergillus nidulans.
The false negative compounds, carbon tetrachloride and linoleic acid peroxide, induce somatic segregation in A. nidulans, but are negative or weak in inducing gene mutation in a haploid strain of the same organism. The other carcinogen tested, CHCl3, was negative in both tests. A model involving free-radical formation is proposed to explain the results. Finally, cysteamine, a free-radical scavenger, could partially counteract the genotoxicity of CCl4. The existence of carcinogens, predominantly capable of inducing chromosomal rearrangements through its action on structures other than DNA is stressed.
D001233:Aspergillus nidulans / Q000187:drug effects; D002251:Carbon Tetrachloride / Q000633:toxicity*; D005609:Free Radicals; D008041:Linoleic Acids; D008054:Lipid Peroxides / Q000633:toxicity*; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects*; D013329:Structure-Activity Relationship
D005609:Free Radicals; D008041:Linoleic Acids; D008054:Lipid Peroxides; D002251:Carbon Tetrachloride