Insulin-like immunoreactivity in the rat brain during postnatal ontogenesis.
The regional distribution and the cellular localization of insulin-immunoreactive material in the rat brain has been studied during postnatal ontogenesis by use of radioimmunoassay and immunocytochemistry. It could be shown that there is a decrease in the amount of the peptide in the rat brain during postnatal maturation of the organ. This decline in insulin concentration is morphologically evident by a strong reduction of insulin positive nerve cells. Our findings support the hypothesis that insulin might play important roles as a nerve growth-promoting factor.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001923:Brain Chemistry; D002540:Cerebral Cortex / Q000378:metabolism; D007328:Insulin / Q000032:analysis* / Q000097:blood / Q000378:metabolism; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin