Cholera toxin-binding T cells in the human peripheral blood at different ages.
The capacity of human T cells to bind cholera toxin was shown to decrease with age. In aged humans, the number of cells capable of binding high concentrations of cholera toxin was lower than that in young humans. The method presented in this paper may be useful as one of the indicators of aging of the immune system.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D002772:Cholera Toxin / Q000276:immunology / Q000378:metabolism*; D005260:Female; D005455:Fluorescent Antibody Technique; D005677:G(M1) Ganglioside / Q000378:metabolism; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D011948:Receptors, Antigen, T-Cell / Q000032:analysis* / Q000502:physiology; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic / Q000032:analysis* / Q000502:physiology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000378:metabolism
D011948:Receptors, Antigen, T-Cell; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; C023552:choleragen receptor; D005677:G(M1) Ganglioside; D002772:Cholera Toxin