Mating and pregnancy can occur in genetically hypogonadal mice with preoptic area brain grafts.
Adult female hypogonadal mice, in whom hypogonadism is secondary to a genetic deficiency in hypothalamic gonadotropin-releasing hormone (GnRH), are infertile. Mating, pregnancy, and delivery of healthy litters were achieved after transplantation of normal fetal preoptic area tissue, a major site of GnRH-containing cell bodies, into the third ventricle of adult female hypogonadal mice. Immunocytochemistry revealed GnRH-containing neurons in the grafts and GnRH-containing processes extending to the lateral median eminence of the host brains.
D000818:Animals; D001923:Brain Chemistry; D002552:Cerebral Ventricles / Q000473:pathology; D003307:Copulation; D005260:Female; D007006:Hypogonadism / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D007247:Infertility, Female / Q000209:etiology / Q000628:therapy*; D008297:Male; D051379:Mice; D009474:Neurons / Q000032:analysis; D010060:Ovulation; D010906:Pituitary Hormone-Releasing Hormones / Q000032:analysis / Q000172:deficiency*; D011247:Pregnancy; D011301:Preoptic Area / Q000637:transplantation*; D012098:Reproduction
D010906:Pituitary Hormone-Releasing Hormones