[Induction of T-cells--producers of macrophage migration inhibitory factors by mutant H-2 antigens in vivo].
C57BL/6 (H-2b) mice were immunized once intravenously by irradiated (1500 rad) spleen cells of mutant strains B6.C-H (z1)Y (H- 2bm1 ) and BB. M505Y (H- 2bm3 ), by the cells of allogeneic strain B10.D2 (H-2d) (in positive control) and syngeneic strain C57BL/6 (in negative control). It was demonstrated that MIF-producing T cells can react to mutant H-2 antigens and that this reaction is revealed on the 1st day after intravenous immunization in vivo. It is suggested that MIF-producing T cells can participate in the immunological surveillance of slight changes in the major histocompatibility complex antigens through mobilization of macrophage effector functions.
D000818:Animals; D006183:H-2 Antigens / Q000235:genetics* / Q000276:immunology; D008263:Macrophage Migration-Inhibitory Factors / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation; D013601:T-Lymphocytes / Q000276:immunology*
D006183:H-2 Antigens; D008263:Macrophage Migration-Inhibitory Factors
Induktsiia T-kletok--produtsentov faktora podavleniia migratsii makrofagov mutantnymi antigenami H-2 in vivo.