Potential novel methods for insulin administration: II. Self-regulating internal drug delivery systems.
Several glycosylated insulins were synthesized and their binding constants to a lectin, Concanavalin A (Con A), as compared to that of glucose, were assessed. When Con A-glycosylated insulins were placed in fluids containing different concentrations of glucose, competitive displacement of glycosylated insulin occurred to a degree dependent upon the ambient concentration of glucose. As these glycosylated insulins possess a biological activity (80% of that of standard soluble insulin) such results demonstrate the beginnings of a "chemical" artificial beta cell.
D000818:Animals; D001667:Binding, Competitive; D003208:Concanavalin A; D005947:Glucose; D007328:Insulin / Q000008:administration & dosage*; D007332:Insulin Infusion Systems; D051381:Rats
D007328:Insulin; D003208:Concanavalin A; D005947:Glucose