The effect of miconazole on ergosterol-less mutant of Candida albicans.
The effect of miconazole in fungistatic concentration on an ergosterol-competent Candida albicans strain and its ergosterol-nonproducing mutant was investigated by scanning and transmission electron microscopy. The ergosterol-less mutant showed pronounced alterations by scanning electron microscopy. The increased sensitivity to miconazole of the ergosterol-less mutant was attributed to an altered plasma membrane composition and rigidity.
D002176:Candida albicans / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure; D004352:Drug Resistance, Microbial; D004875:Ergosterol / Q000096:biosynthesis*; D008825:Miconazole / Q000494:pharmacology*; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009154:Mutation; D009761:Nystatin / Q000494:pharmacology
D009761:Nystatin; D008825:Miconazole; D004875:Ergosterol