Distribution of monkey esophagus antigens reactive with IgA-class antibodies in the sera of dermatitis herpetiformis patients.
Antibodies of IgA class reactive to the lining of the smooth muscle bundles, i.e., endomysium (EmA), are present in the sera of patients with dermatitis herpetiformis and coeliac disease. These antibodies can be detected on monkey esophagus, a substrate of choice for pemphigus and pemphigoid antibodies. The amount of antigen reactive with IgA-EmA is greatest in the lower portion of the esophagus and decreases towards the uppermost part.
D000818:Animals; D001323:Autoantibodies; D002446:Celiac Disease / Q000276:immunology; D002522:Chlorocebus aethiops; D003874:Dermatitis Herpetiformis / Q000276:immunology*; D004947:Esophagus / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D009130:Muscle, Smooth / Q000276:immunology; D010391:Pemphigoid, Bullous / Q000276:immunology; D010392:Pemphigus / Q000276:immunology
D001323:Autoantibodies; D007070:Immunoglobulin A