Induction of heart alterations by immunization with subcellular fractions from Crithidia fasciculata.
Immunization of mice with subcellular fractions of C. fasciculata led to myocarditis and electrocardiographic alterations similar to those induced by immunization with T. cruzi, the etiological agent of Chagas' disease, suggesting the presence of similar cardiotoxic antigens in both trypanosomatid flagellates.
D000818:Animals; D003421:Crithidia / Q000276:immunology*; D004562:Electrocardiography; D005455:Fluorescent Antibody Technique; D051379:Mice; D009205:Myocarditis / Q000209:etiology*; D009206:Myocardium / Q000473:pathology; D013347:Subcellular Fractions / Q000276:immunology