Walking capacity of patients with intermittent claudication during chronic antihypertensive treatment with metoprolol and methyldopa.
In a placebo-controlled double-blind crossover trial, the effect of a 3-week course of treatment with metoprolol (100-200 mg daily) and methyldopa (500-1000 mg daily) on walking capacity on a treadmill with increasing work load was studied in 14 hypertensive patients with intermittent claudication. The walking capacity was not affected by the antihypertensive treatment.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005080:Exercise Test; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007383:Intermittent Claudication / Q000150:complications / Q000503:physiopathology*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D008750:Methyldopa / Q000494:pharmacology / Q000627:therapeutic use*; D008790:Metoprolol / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged
D008750:Methyldopa; D008790:Metoprolol