[Drug modification of mechanically evoked itching and the concomitant equivalents, erythema and wheals of the skin. Clinico-experimental studies].
In 20 volunteers with normal skin, itching and concomitant erythemas and wheals were produced by mechanical stimulation with a magnetic oscillation system. In a placebo-controlled, randomized double-blind study with twice cross-over, a calcium-vitamin-D-combination as single dose ampoules for peroral application was tested. A significant decrease (p less than 0,001) of the areas of erythema and wheal and itching in treated persons, compared with non-treated and placebo-treated volunteers serving for controls, is showing the antiallergic effectiveness of the tested preparation.
D000328:Adult; D001205:Ascorbic Acid; D002118:Calcium / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004338:Drug Combinations / Q000627:therapeutic use; D004872:Ergocalciferols / Q000627:therapeutic use*; D004890:Erythema / Q000188:drug therapy*; D005260:Female; D005942:Gluconates; D006801:Humans; D008297:Male; D008875:Middle Aged; D010812:Physical Stimulation; D011537:Pruritus / Q000188:drug therapy*; D014581:Urticaria / Q000188:drug therapy*
D004338:Drug Combinations; D004872:Ergocalciferols; D005942:Gluconates; C039981:frubiase; D001205:Ascorbic Acid; D002118:Calcium
Zur medikamentösen Beeinflussung von mechanisch ausgelöstem Juckreiz und der begleitenden Aquivalente Erytheme und Quaddeln der Haut. Klinisch-experimentelle Untersuchungen.