title: Genital herpes simplex virus infections in adults.
abstract: With the decline in prevalence of childhood-acquired oral-labial herpes simplex type 1 infections in some populations and the increasing incidence of genital herpes infections in adults, clinicians are more likely to see patients with severe primary, first-episode genital herpes infections. Complications of these primary infections may include aseptic meningitis and urine retention secondary to sacral radiculopathy or autonomic dysfunction. Presented are the clinical course of first-episode and recurrent infections, complications, diagnostic laboratory methods, and results of controlled clinical trials evaluating the efficacy of topical, intravenous, and oral preparations of acyclovir.
mesh_terms: D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use; D000284:Administration, Oral; D000287:Administration, Topical; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D004279:DNA, Viral / Q000032:analysis; D004352:Drug Resistance, Microbial; D005260:Female; D006558:Herpes Genitalis / Q000150:complications / Q000188:drug therapy / Q000382:microbiology; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications; D007275:Injections, Intravenous; D008297:Male; D009422:Nervous System Diseases / Q000209:etiology; D011349:Proctitis / Q000382:microbiology; D011472:Prostatitis / Q000382:microbiology; D012008:Recurrence; D012737:Sex Factors; D012749:Sexually Transmitted Diseases / Q000382:microbiology; D014522:Urethral Diseases / Q000382:microbiology
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral; D000212:Acyclovir