title: Investigations into the direct effects of insulin on hepatic ketogenesis, lipoprotein secretion and pyruvate dehydrogenase activity.
abstract: In the rat liver perfused with whole rat blood containing either decreased or increased concentrations of non-esterified fatty acids, insulin decreased production of acetoacetate and 3-hydroxybutyrate and stimulated secretion of very-low-density-lipoprotein triacylglycerol. In these same livers, pyruvate dehydrogenase activity was not altered by insulin addition, although it was diminished by non-esterified fatty acids.
mesh_terms: D000818:Animals; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007328:Insulin / Q000494:pharmacology*; D007657:Ketone Bodies / Q000096:biosynthesis*; D008074:Lipoproteins / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007657:Ketone Bodies; D008074:Lipoproteins; D011768:Pyruvate Dehydrogenase Complex