Cardiac tumors of mice.
Of the 7 primary tumors of the mouse heart, accessed at the Registry of Experimental Cancers, 3 were mesenchymal cell sarcomas, 3 were hemangioendotheliomas, and 1 was a mesenchymoma. The mesenchymal cell sarcomas metastasized via the bloodstream to lungs, kidneys, and spleen. Five of the tumors arose in mice treated with ionizing radiation. Previously, only 3 primary cardiac tumors of mice have been reported. Tumors of the heart as part of multifocal neoplasms of a single histologic type were observed in 3 mice; 2 of these tumors were type B reticulum cell sarcomas, and 1 was a reticulum cell sarcoma not otherwise specified. Of the metastatic tumors of the heart, 12 were from alveologenic carcinoma, squamous cell carcinoma, or carcinosarcoma of the lung, 4 were from sarcoma of the subcutaneous soft tissue, and 1 each was from a subcutaneous transplant of a malignant schwannoma and from an alveologenic tumor of the lung.
D000818:Animals; D005260:Female; D006338:Heart Neoplasms / Q000473:pathology* / Q000556:secondary; D006390:Hemangioendothelioma / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology; D008297:Male; D008637:Mesenchymoma / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D012042:Registries; D012513:Sarcoma, Experimental / Q000473:pathology