Efficacy of aztreonam in treatment of experimental syphilis in rabbits.
The efficacy of aztreonam (SQ 26,776) in the therapy of active syphilis infection was evaluated in the rabbit model. Aztreonam was effective in treating active syphilis at a dose of 25 mg/kg given intramuscularly twice daily for 10 days; doses of 2.5 and 0.25 mg/kg were not effective.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001398:Aztreonam; D008297:Male; D010401:Penicillin G Benzathine / Q000494:pharmacology; D011817:Rabbits; D013587:Syphilis / Q000188:drug therapy* / Q000382:microbiology; D014210:Treponema pallidum
D000900:Anti-Bacterial Agents; D001398:Aztreonam; D010401:Penicillin G Benzathine