title: Modulation of renal baroreceptor function by catecholamines and salt intake in the conscious dog.
abstract: We have examined the relationship between plasma renin activity and renal perfusion pressure by determining the stimulus-response curve of the renal baroreceptor in conscious, uninephrectomized dogs, and the modulation induced by catecholamines and varying salt intake. Renal perfusion pressure was controlled by step-wise inflation of a constricting cuff previously implanted around the renal artery. The stimulus-response curve of the renal baroreceptor may be divided into two ranges: a relatively flat portion close to normal pressure (100 mmHg), and a much steeper section below a "threshold" pressure of 75-80 mmHg. Epinephrine (I.V. or I.R.) produced a parallel shift of the curve to the right, i.e., a smaller drop in pressure was needed to reach "threshold." Changing the diet from normal salt intake (80 meq/day) to a low salt intake (10 meq/day) increased the gain of the stimulus-response curve. Thus, the same elevated PRA may be reached either by a shift of the curve to the right, or by increase in gain.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002395:Catecholamines / Q000494:pharmacology*; D004285:Dogs; D007668:Kidney / Q000294:innervation* / Q000502:physiology; D008297:Male; D011311:Pressoreceptors / Q000187:drug effects / Q000502:physiology*; D012083:Renin / Q000097:blood; D012965:Sodium Chloride / Q000494:pharmacology*
chemical_list: D002395:Catecholamines; D012965:Sodium Chloride; D012083:Renin