The fetal renin-angiotensin system in pregnancy-induced hypertension.
Maternal and fetal blood samples were obtained from 10 normotensive primigravidae and 10 primigravidae with pregnancies complicated by hypertension and proteinuria. Measurements were performed of plasma renin activity (PRA), plasma renin concentration (PRC) and plasma renin substrate (PRS). PRA and PRC were significantly higher in cord artery and cord vein blood than in maternal venous blood in normotensive women, and PRS was significantly lower. PRS levels were lower in maternal plasma of hypertensive women, and, although PRC and PRA were lower in the cord blood of infants born to hypertensive women, these differences did not achieve statistical significance.
D000808:Angiotensinogen / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood*; D012083:Renin / Q000097:blood; D012084:Renin-Angiotensin System
D000808:Angiotensinogen; D012083:Renin