title: Prophylactic trimethoprim for prostatectomy.
abstract: The efficacy of prophylaxis for control of infection in prostatectomy was studied in 260 patients in a double-blind clinical trial using a single dose of 300 mg trimethoprim and a placebo. Results in 141 transurethral and 119 patients operated on abdominally were analyzed separately. Neither group showed significant heterogeneity of risk factors. Trimethoprim did not prevent bacteremia during operation. No significant difference in infection between trimethoprim and placebo groups was found in either group. After several studies the efficacy of antimicrobial prophylaxis in prostatectomy still remains to be proved; it may be too low to warrant such a prophylaxis in general.
mesh_terms: D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005069:Evaluation Studies as Topic; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication; D011468:Prostatectomy / Q000379:methods; D018805:Sepsis / Q000517:prevention & control*; D014295:Trimethoprim / Q000008:administration & dosage*
chemical_list: D014295:Trimethoprim