title: [Gallbladder contractility, cholelithiasis and autonomic neuropathy in diabetes mellitus].
abstract: Decrease in gall-bladder surface area, as obtained by ultrasound, was measured in 52 patients with insulin-dependent diabetes (27 with and 25 without autonomic neuropathy) 60 minutes after administration of the bile stimulant Biloptin. The post-stimulation area was 33 +/- 6% of initial value in patients with autonomic neuropathy, and 67 +/- 8% (P less than 0.0005) in those without autonomic neuropathy. Comparison with insulin-dependent chronic diabetics matched for sex, age and duration of illness, demonstrated that heart-rate variability in cholelithiasis was less than in the control subjects (P less than 0.05). It is concluded that autonomic neuropathy, measured by the occurrence of spontaneous vagotomy, in insulin-dependent diabetics is an important risk factor in the overall pathogenesis of cholelithiasis.
mesh_terms: D000328:Adult; D000368:Aged; D002769:Cholelithiasis / Q000209:etiology*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000503:physiopathology; D003929:Diabetic Neuropathies / Q000209:etiology*; D005260:Female; D005704:Gallbladder / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D007487:Ipodate / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D014463:Ultrasonography; D014628:Vagotomy
chemical_list: D014280:Triglycerides; D007487:Ipodate
vernacular_title: Gallenblasenkontraktilität, Cholelithiasis und autonome Neuropathie bei Diabetes mellitus.