Long-term clinical evaluation of suprofen and aspirin in patients with osteoarthritis.
The safety and efficacy of suprofen 200 mg q.i.d. and aspirin 650 mg q.i.d. in the treatment of chronic pain due to osteoarthritis were compared in a double-blind, randomized, parallel group study over a 12-week period. Suprofen was comparable to aspirin in the relief of pain and improvement in activity impairment. Results of ocular examination, laboratory data, and vital signs examinations indicated no clinically significant changes for suprofen. No serious side effects were reported by either group.
D001241:Aspirin / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000097:blood / Q000188:drug therapy*; D010666:Phenylpropionates / Q000627:therapeutic use*; D011897:Random Allocation; D013496:Suprofen / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
D010666:Phenylpropionates; D013496:Suprofen; D001241:Aspirin