Influence of a skin allograft on frequencies of CTL precursor in peripheral blood of the dog.
Alloantigen-specific cytotoxic T lymphocytes (CTL) and their precursors (CTL-P) have been determined in the peripheral blood of skin allografted dogs. CTL-P frequencies increased rapidly after transplantation and reached maximal values after complete rejection of the skin allograft. Differences in the time response kinetics of CTL-P frequencies between recipients were not correlated with the length of graft survival. The CTL-P frequencies declined after days 13-20 and appeared still to be elevated 30 days after rejection of the graft.
D000818:Animals; D004285:Dogs; D006084:Graft Rejection; D007700:Kinetics; D007958:Leukocyte Count; D008297:Male; D016038:Skin Transplantation; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology*; D013997:Time Factors; D014184:Transplantation, Homologous