In vivo injection of dipyridamole stimulates the synthesis of prostacyclin-like substances in human varicose veins.
The influence of dipyridamole, given by a bolus injection (30 mg i. v.) on the synthesis of prostacyclin-like substances (PGI2-LS) in human shank varicose veins was investigated. The pretreatment with dipyridamole enhances the second step in PGI2 biosynthesis (transformation of endoperoxide to PGI2) in these preparations.
D000328:Adult; D004176:Dipyridamole / Q000494:pharmacology*; D011464:Epoprostenol / Q000096:biosynthesis*; D006801:Humans; D066298:In Vitro Techniques; D008875:Middle Aged; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology; D044262:Prostaglandin H2; D011463:Prostaglandins H / Q000494:pharmacology; D014648:Varicose Veins / Q000378:metabolism*
D011450:Prostaglandin Endoperoxides, Synthetic; D011463:Prostaglandins H; D044262:Prostaglandin H2; D004176:Dipyridamole; D011464:Epoprostenol