Premalignant and malignant skin lesions in renal transplant patients.
Among 129 renal transplant patients with 3-16 years of posttransplant observation time, and residents in a low ultraviolet radiation area, 25 (19.4%) had premalignant or malignant skin lesions, a 3-fold increase over a control population collected randomly. Thirteen (10.1%) had skin cancer, a 7-fold increase. Nine patients had multiple lesions; none had metastatic disease. Multiple regression analysis revealed age, outdoor occupation, and transplantation/immunosuppression to be equally significant risk factors for skin malignancy. Transplant patients should be educated and periodically examined for early detection of skin malignancies.
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000453:epidemiology* / Q000209:etiology; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000209:etiology; D013548:Sweden; D014180:Transplantation / Q000009:adverse effects*; D014466:Ultraviolet Rays / Q000009:adverse effects
D007166:Immunosuppressive Agents