title: Developmental changes in rat liver alcohol dehydrogenase.
abstract: Hepatic alcohol dehydrogenase activity and mass content change coordinately during development in male rats. Enzyme activity and mass content increase continuously after birth to 100 and 80% of maximal values within 6 weeks (2.6 +/- 0.4 mumole/min/g liver and 92 +/- 20 micrograms/g liver), respectively. When expressed per milligram of soluble proteins, both parameters peak at 3 weeks (0.052 +/- 0.002 mumole/min/mg protein and 2.0 +/- 0.4 micrograms/mg protein) and then decrease gradually to plateau levels. These decreases probably arise from a "surge" in soluble liver protein levels that occurs after weaning. Similar developmental patterns also occur in female rats. These findings are the first quantitative measurements of this enzyme in developing animals.
mesh_terms: D000375:Aging; D000426:Alcohol Dehydrogenase; D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000818:Animals; D005260:Female; D008099:Liver / Q000196:embryology / Q000201:enzymology / Q000254:growth & development*; D008297:Male; D011247:Pregnancy; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
chemical_list: D011506:Proteins; D000429:Alcohol Oxidoreductases; D000426:Alcohol Dehydrogenase