The mouse footpad test--sensitive to small proportions of drug-resistant bacilli in a sample of M. leprae.
In experiments at the Radda Barnen Research Laboratories of the SLR & TC Karigiri, the mouse footpad test was demonstrated to detect DDS-resistant M.leprae even if as few as 0.1% (1 in 1000) of the M. leprae tested were DDS-resistant. The mouse footpad test appears to be sensitive to minute proportions of drug-resistant bacilli in samples of M. leprae tested.
D000818:Animals; D003622:Dapsone / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D051379:Mice; D008808:Mice, Inbred CBA; D008826:Microbial Sensitivity Tests / Q000379:methods; D009166:Mycobacterium leprae / Q000187:drug effects*
D003622:Dapsone