title: Induction of labor using high-dose or low-dose prostaglandin vaginal pessaries.
abstract: Two hundred women were studied in a randomized controlled trial of induction of labor using high-dose (3 mg) or low-dose (0.5 mg) prostaglandin E2 vaginal pessaries. Induction using 3-mg pessaries was more successful, with a shorter overall induction-delivery interval and less requirement for analgesia, although uterine hyperstimulation occurred in two patients. In contrast, the low-dose regimen did not cause hypertonus and, though less successful in inducing labor, the total dose of prostaglandin E2 used was considerably less than in the 3-mg group. The cesarean section rate when the cervix was initially unfavorable was high in both groups (high dose 18.2%, low dose 16.7%). The response to prostaglandin E2 did not relate closely to the initial cervical state.
mesh_terms: D002585:Cesarean Section; D002986:Clinical Trials as Topic; D015232:Dinoprostone; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D010570:Pessaries; D011247:Pregnancy; D011458:Prostaglandins E / Q000008:administration & dosage*; D011897:Random Allocation; D014590:Uterine Contraction / Q000187:drug effects; D014621:Vagina
chemical_list: D011458:Prostaglandins E; D015232:Dinoprostone