Immunofluorescence in cutaneous leishmaniasis.
A case of acute cutaneous leishmaniasis is reported in which skin biopsy of the lesion revealed deposits of IgM, fibrinogen and C3 in the blood vessel wall and granular deposits of IgG and C3 at the dermoepidermal junction. No immune complexes were detected in the healthy unaffected skin in the same patient and no circulating immune complexes were found in the blood. This case demonstrates tissue-bound immune complexes in cutaneous leishmaniasis.
D000208:Acute Disease; D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis*; D001706:Biopsy; D001808:Blood Vessels / Q000032:analysis; D003176:Complement C3 / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007896:Leishmaniasis / Q000276:immunology* / Q000473:pathology; D008297:Male; D008856:Microscopy, Fluorescence; D012867:Skin / Q000098:blood supply / Q000473:pathology
D000936:Antigen-Antibody Complex; D003176:Complement C3; D007136:Immunoglobulins