Prostaglandins, related compounds, and the perinatal pulmonary circulation.
It is clear that prostaglandins and related compounds are important in the physiology and pathophysiology of the perinatal pulmonary circulation. This article focuses on what is known about prostaglandin-related compounds (PRC) in the pulmonary circulation of the developing and newly born mammal. Also included is a discussion of the effects of PRC on the ductus arteriosus and on the systemic circulation.
D000818:Animals; D000831:Animals, Newborn; D001095:Arachidonic Acids / Q000378:metabolism / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D011464:Epoprostenol / Q000494:pharmacology; D005260:Female; D005333:Fetus / Q000502:physiology*; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000494:pharmacology; D006976:Hypertension, Pulmonary / Q000503:physiopathology; D007231:Infant, Newborn; D008168:Lung / Q000098:blood supply; D010547:Persistent Fetal Circulation Syndrome / Q000503:physiopathology; D011247:Pregnancy; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D015230:Prostaglandin D2; D011453:Prostaglandins / Q000378:metabolism / Q000502:physiology*; D011457:Prostaglandins D / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D011652:Pulmonary Circulation / Q000187:drug effects; D013189:SRS-A / Q000494:pharmacology / Q000502:physiology; D012756:Sheep; D013931:Thromboxanes / Q000502:physiology; D014655:Vascular Resistance; D014661:Vasoconstriction
D001095:Arachidonic Acids; D006893:Hydroxyeicosatetraenoic Acids; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D011457:Prostaglandins D; D011458:Prostaglandins E; D011460:Prostaglandins F; D013189:SRS-A; D013931:Thromboxanes; D011464:Epoprostenol; D015230:Prostaglandin D2