Myocardial protection: a comparison of cold blood and cold crystalloid cardioplegia.
Two hundred seven consecutive patients were randomized into four groups based on left ventricular end-diastolic pressure and subsequently into groups receiving crystalloid cardioplegia or blood cardioplegia. Hemodynamic data and enzymatic evidence of myocardial ischemia were examined postoperatively. We found slight but significant improvement in the blood cardioplegia group regarding left ventricular stroke work index. Similarly, the levels of creatine kinase and serum glutamic oxaloacetic transaminase were slightly but significantly better with blood cardioplegia. We believe that the technique of blood cardioplegia offers a slight but statistically significant advantage.
D000368:Aged; D001219:Aspartate Aminotransferases / Q000097:blood; D001769:Blood; D002302:Cardiac Output / Q000187:drug effects; D002986:Clinical Trials as Topic; D003080:Cold Temperature; D001026:Coronary Artery Bypass; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006324:Heart Arrest, Induced / Q000379:methods*; D006439:Hemodynamics; D006801:Humans; D007527:Isoenzymes / Q000097:blood; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000201:enzymology; D011188:Potassium / Q000627:therapeutic use; D017680:Potassium Compounds; D011897:Random Allocation; D013318:Stroke Volume / Q000187:drug effects; D013997:Time Factors
D007527:Isoenzymes; D017680:Potassium Compounds; C018369:potassium cardioplegic solution; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase; D011188:Potassium