Effect of certain factors modifying the lipid-mobilizing activity in vitro in the serum of rats during hypothermia.
The serum of hypothermic animals shows in vitro the ability of mobilizing fatty acids from the adipose tissue. This ability is quantitatively comparable to the lipolytic activity of glucagon but is lower than that of adrenaline. Propranolol decreases the lipid-mobilizing activity in the serum of hypothermic animals in vitro. Similarly insulin added to the medium with the serum of hypothermic animals decreased the lipid-mobilizing activity.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D046508:Culture Techniques; D004837:Epinephrine / Q000494:pharmacology; D005227:Fatty Acids / Q000378:metabolism; D005934:Glucagon / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D010455:Peptides / Q000097:blood*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D005227:Fatty Acids; D007328:Insulin; D010455:Peptides; C008287:lipid mobilizing substance; D005934:Glucagon; D011433:Propranolol; D004837:Epinephrine