title: Cyclofenil treatment of scleroderma--a controlled study.
abstract: A double-blind cross-over study of cyclofenil and placebo treatments was conducted in 11 scleroderma patients. Each treatment period was for four months. A range of subjective and objective measurements failed to reveal any consistent or obvious response to cyclofenil. One patient died of his disease during active treatment. Four were withdrawn because of liver dysfunction which was attributed to cyclofenil. It remains to be seen whether treatment over longer periods will exert a clinically significant effect.
mesh_terms: D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003408:Cresols / Q000627:therapeutic use*; D003506:Cyclofenil / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D012595:Scleroderma, Systemic / Q000188:drug therapy*
chemical_list: D003408:Cresols; D010919:Placebos; D003506:Cyclofenil