Hyperoxia stimulates alveolar macrophages to produce and release a factor which increases neutrophil adherence.
Hyperoxia stimulates alveolar macrophages (AM) to make and release a factor which increases neutrophil adherence to nylon fiber. Production of the neutrophil adherence-stimulating factory by AM exposed to hyperoxia is maximal after AM have been exposed to hyperoxia for 72 h and requires protein synthesis by intact AM. The adherence factor is heat-labile and by column chromatography elutes in a molecular-weight range of approximately 8000-18,000 daltons. The lungs of animals exposed to hyperoxia and contribute to neutrophil-mediated lung injury from hyperoxia.
D000818:Animals; D002448:Cell Adhesion; D002630:Chemotactic Factors / Q000096:biosynthesis* / Q000502:physiology; D006358:Hot Temperature; D006801:Humans; D016209:Interleukin-8; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D008970:Molecular Weight; D009504:Neutrophils / Q000502:physiology; D010100:Oxygen / Q000494:pharmacology*; D014176:Protein Biosynthesis; D011650:Pulmonary Alveoli / Q000166:cytology; D011817:Rabbits
D002630:Chemotactic Factors; D016209:Interleukin-8; D010100:Oxygen