title: The effect of inadvertent intraoperative perforation on survival and recurrence in colorectal cancer.
abstract: Inadvertent perforation of the bowel during curative resection for colorectal cancer has serious consequences. In 174 curative resections with spillage, five-year survival was 29 per cent. In 67 patients where the cancer itself was disrupted during dissection, five-year survival fell to 14 per cent in the colon and to 9.3 per cent in the rectum. Local recurrence developed in 65 per cent of spillage cases. In Dukes' C tumors that were perforated during surgery, local recurrence occurred in 87 per cent. As surgeons, our efforts must be directed toward preventing injury to the bowel during definitive resection of colorectal cancers. The instillation of tumoricidal solutions within the bowel lumen and the application of bowel ligatures prior to dissection may help toward preventing recurrence, should inadvertent perforation and spillage occur.
mesh_terms: D003110:Colonic Neoplasms / Q000401:mortality / Q000601:surgery*; D004210:Dissection; D006801:Humans; D007416:Intestinal Perforation / Q000209:etiology*; D007431:Intraoperative Complications; D009364:Neoplasm Recurrence, Local; D009518:New York; D012004:Rectal Neoplasms / Q000401:mortality / Q000601:surgery*; D013536:Suture Techniques