title: Recombinant alpha interferon in retreatment of two patients with pulmonary lymphoma. Dramatic responses with resolution of pulmonary complications.
abstract: Two patients with advanced lymphoma involving the lungs that was resistant to chemotherapy had an initial excellent response to interferon therapy. After two months of stable disease, alpha interferon A therapy was discontinued, with relapse of a few months later. Both patients had extensive pulmonary involvement with relapse of the lymphoma, and both showed a dramatic response to retreatment with alpha interferon A. Unusual interferon-related pulmonary complications were observed in one patient, and their management is detailed.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D002986:Clinical Trials as Topic; D004274:DNA, Recombinant; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects / Q000235:genetics / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000000981:diagnostic imaging / Q000628:therapy*; D008207:Lymphatic Metastasis; D008223:Lymphoma / Q000000981:diagnostic imaging / Q000628:therapy*; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D011859:Radiography; D012128:Respiratory Distress Syndrome / Q000209:etiology
chemical_list: D000305:Adrenal Cortex Hormones; D004274:DNA, Recombinant; D007370:Interferon Type I