Human oncogenes.
The information published on human oncogenes up to the fall of 1983 is reviewed. Retroviral oncogenes, proto-oncogenes, and cellular transforming genes are compared. Transforming genes derived from the ras gene family are described in detail. The different mechanisms of activation of proto-oncogenes are summarized. Finally, the concerted or sequential action of cellular transforming genes in the multi-step process of carcinogenesis is discussed.
D000818:Animals; D002273:Carcinogens; D002415:Cats; D002427:Cebidae; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D002645:Chickens; D005784:Gene Amplification; D005814:Genes, Viral; D006801:Humans; D051379:Mice; D009154:Mutation; D009369:Neoplasms / Q000235:genetics* / Q000382:microbiology; D009857:Oncogenes; D051381:Rats; D012190:Retroviridae / Q000235:genetics* / Q000254:growth & development; D014178:Translocation, Genetic; D014412:Tumor Virus Infections / Q000235:genetics* / Q000382:microbiology; D014421:Turkey; D014775:Virus Activation
D002273:Carcinogens