Glucose in the dialyzate does not reduce the free amino acid loss during routine hemodialysis of non-fasting patients.
In order to clarify the effect of dialyzate glucose on free amino acid loss during routine 5 hr hemodialysis (HD), 10 stable non-fasting HD patients were dialyzed twice using dialyzates (Na 141, K 2.5, Ca 3.5, Cl 101, Mg 1.5, Acetate 36 mEql) with (500 mg/dl) or without glucose. Total free amino acid loss in the dialyzate and plasma free amino acids were measured using a liquid chromatograph amino acid analyzer. Total free amino acid losses into the dialyzate with and without glucose were 6598 +/- 482, and 6482 +/- 174 mg respectively. This is not statistically significant. The plasma concentration of free amino acid fell considerably during dialysis, but there was no significant difference between the two types of dialyzates used. We concluded that the addition of glucose to the dialyzate does not reduce the free amino acid loss during routine HD of non-fasting patients. This result does not accord with a previous report that adding glucose to the dialyzate decreases the loss of free and bound amino acid during dialysis.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis
D000596:Amino Acids; D001786:Blood Glucose; D007328:Insulin; D005947:Glucose