Inhibition of gastric acid secretion elicited by D-glucose anomers in man.
Acid outputs from the stomach were measured after venous administration of D-glucose and its optical anomers in men with insulin hypoglycemia. A significant decrease in gastric acid output was noted after the administration of 277 mM alpha-D-glucose, 277 mM optically equilibrated D-glucose consisting of 36% alpha-anomer and 64% beta-anomer, or 277 mM beta-D-glucose. The effect of beta-D-glucose was most potent in the three forms of D-glucose. NaCl solution, however, produced no appreciable change in the acid outputs. Our findings suggested that, in humans, beta-D-glucose in the blood may play an important role in the activation of glucose-sensitive mechanisms controlling vagally mediated secretion of gastric acid.
D000328:Adult; D005744:Gastric Acid / Q000378:metabolism*; D005750:Gastric Juice / Q000187:drug effects*; D005947:Glucose / Q000494:pharmacology*; D006801:Humans; D007003:Hypoglycemia / Q000378:metabolism; D007328:Insulin; D008297:Male; D013237:Stereoisomerism
D007328:Insulin; D005947:Glucose