[Biochemical basis for the spasmolytic effect of isoquinoline and phenothiazine derivatives].
Experiments with isolated ring-like strips of pig heart veins and arteries and those with rat small intestinal strips made in the presence of hyperpotassium contracture have demonstrated that spasmolytic activity of papaverine, nospa, nonachlazine, and ethmozine is a consequence of the reduced respiratory intensity and phosphorylation in smooth muscle mitochondria. No changes in the anaerobic glycolysis rate have been found after drug administrations.
D000818:Animals; D066298:In Vitro Techniques; D008931:Mitochondria, Muscle / Q000187:drug effects; D016293:Moricizine; D009130:Muscle, Smooth / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009628:Nonachlazine / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects; D010208:Papaverine / Q000031:analogs & derivatives / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology*; D010640:Phenothiazines / Q000494:pharmacology; D010766:Phosphorylation; D051381:Rats; D013552:Swine
D010276:Parasympatholytics; D010640:Phenothiazines; D016293:Moricizine; D009628:Nonachlazine; C005317:drotaverin; D010208:Papaverine
Biokhimicheskaia osnova spazmoliticheskogo éffekta proizvodnykh izokhinolina i fenotiazina.