[Indefinite survival of pancreatic allografts under cyclosporin A treatment in rats].
Reports in the published literature suggest that cyclosporine A is less effective in the prevention of pancreatic graft rejection. Prolonged survival (97.9 days) of pancreatic allografts was obtained by the use of cyclosporine A in the rat, and indefinite survival was reported in 2 animals. Toxic accidents related to the compound were not observed. A complete histologic and metabolic study of pancreatic grafts showed that two types of response were possible according to whether the graft was rejected or tolerated. Cyclosporine A should be considered as a basic immunosuppressive agent for all types of allograft, including the pancreatic type.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003524:Cyclosporins / Q000008:administration & dosage / Q000494:pharmacology*; D006084:Graft Rejection / Q000187:drug effects; D006085:Graft Survival / Q000187:drug effects*; D008297:Male; D010179:Pancreas / Q000473:pathology; D016035:Pancreas Transplantation; D051381:Rats; D011914:Rats, Inbred BN; D013997:Time Factors
D001786:Blood Glucose; D003524:Cyclosporins
Survie indéfinie d'allogreffes pancréatiques sous cyclosporine A chez le rat.