[Development of mammalian nervous tissue transplanted into the brain and anterior chamber of the eye: problems and prospects].
Some theoretical problems arising in connection with nervous tissue grafting in mammals are discussed. The survival of grafts in the brain and anterior eye chamber is provided by a complex of factors, including peculiarities of immunological reaction, blood-brain barrier and certain characteristics of embryonic nervous tissue. Organotypic development of ectopic grafts suggests a significant autonomy of inner genetic programmes in self-organization of brain structures. Development of the graft-host brain nervous connections is, to a great extent, determined by the factors of topographic closeness and the presence of free postsynaptic structures, without prominent specificity of the graft-brain relationships. Complex neurotrophic interactions, mainly provided by the glial cells, are also found between the graft and damaged host brain. A study of electric activity of the grafted neurons has shown a varying degree of dependence of the functional organization of the brain structures on the environmental afferent influences. The grafts can serve as a chronic endogenous source of neurotransmitters and neurohormones, and, possibly, restore interrupted structural connections, thus providing the compensation of some complex brain functions.
D000375:Aging; D000818:Animals; D000867:Anterior Chamber / Q000276:immunology / Q000502:physiology*; D001369:Axons / Q000648:ultrastructure; D001812:Blood-Brain Barrier; D001921:Brain / Q000276:immunology / Q000502:physiology*; D002415:Cats; D004594:Electrophysiology; D005865:Gestational Age; D006085:Graft Survival; D006168:Guinea Pigs; D006649:Histocompatibility Antigens / Q000276:immunology; D007395:Interneurons / Q000166:cytology; D051379:Mice; D008854:Microscopy, Electron; D009417:Nerve Tissue / Q000196:embryology / Q000276:immunology / Q000637:transplantation*; D009457:Neuroglia / Q000166:cytology; D009928:Organ Specificity; D011817:Rabbits; D051381:Rats; D014181:Transplantation Immunology
D006649:Histocompatibility Antigens
Razvitie nervnoĭ tkani mlekopitaiushchikh pri transplantatsii v mozg i peredniuiu kameru glaza: problemy i perspektivy.