title: [Pancreatic function after pancreatoduodenectomy--correlation between the volume ratio of parenchyma and the number of Langerhans' islets].
abstract: Correlation between the volume ratio of the pancreatic parenchyma and the volume of hydroxyproline in the pancreatic tissue was studied in 9 mongrel dogs with pancreatic-duct ligation. The volume ratio of the pancreatic parenchyma and the number of Langerhans' islets were determined in 11 normal pancreas. And the relationship between the volume ratio of the pancreatic parenchyma in the 37 resected pancreas by pancreatoduodenectomy (PD) and the functions in the remaining pancreas after PD, was examined. The following results were obtained: The method to determine the volume ratio of the pancreatic parenchyma by using a Roller-planimeter proved to be a simple and convenient to find out the extent of pancreatic fibrosis. The volume ratio of the pancreatic parenchyma in normal pancreas was almost uniform over the whole pancreas. The number of Langerhans' islets in the tail of normal pancreas was about 1.5 times as many as that at the resection line by the scheduled PD. The volume ratio of the pancreatic parenchyma and the number of Langerhans' islets after PD were about half that in normal pancreas. Positive correlation was noted between the volume ratio of the pancreatic parenchyma and the post-operative pancreatic juice secreted at the time of PD. In the cases which the volume ratio of the pancreatic parenchyma was over 80%, the pancreatic juice secretion was over 200 ml/day. In many of the cases which the volume ratio of the pancreatic parenchyma was over 70%, the exocrine function in the remaining pancreas was good even three to four years after PD. Correlation was observed between the number of Langerhans' islets at PD and the post-operative glucose tolerance. In the cases which the number of Langerhans' islets was large, more favorable insulin secretory function was observed in the remaining pancreas.
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001650:Bile Duct Neoplasms / Q000601:surgery; D004285:Dogs; D004379:Duodenal Neoplasms / Q000601:surgery; D004386:Duodenum / Q000601:surgery*; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000032:analysis; D007515:Islets of Langerhans / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000032:analysis / Q000503:physiopathology*; D010180:Pancreatectomy; D010186:Pancreatic Function Tests; D010190:Pancreatic Neoplasms / Q000601:surgery; D011184:Postoperative Period
chemical_list: D006909:Hydroxyproline