title: Immunopathology of vitiligo vulgaris, Sutton's leukoderma and melanoma-associated vitiligo in relation to steroid effects. II. The IgG and C3 deposits in the skin.
abstract: Microsome, thyroid and DNA tests on patients with generalized vitiligo vulgaris, with or without Sutton's leukoderma, show a high positive rate without thyroid diseases. A small, but not negligible, amount of IgG and C3 deposits in the basement-membrane zone and keratinocytes, has been frequently seen in these diseases by immunohistology and immuno-electron microscopy. This evidence strongly suggests an autoimmune character for these diseases.
mesh_terms: D000328:Adult; D001327:Autoimmune Diseases / Q000473:pathology; D003176:Complement C3 / Q000032:analysis*; D005260:Female; D005446:Fluocinolone Acetonide / Q000031:analogs & derivatives*; D005447:Fluocinonide / Q000627:therapeutic use*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000032:analysis*; D008297:Male; D008545:Melanoma / Q000150:complications / Q000276:immunology; D008854:Microscopy, Electron; D010859:Pigmentation Disorders / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D014820:Vitiligo / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*
chemical_list: D003176:Complement C3; D007074:Immunoglobulin G; D005446:Fluocinolone Acetonide; D005447:Fluocinonide