A comparison of the effect of flurbiprofen, dexamethasone, and placebo on cyclocryotherapy-induced inflammation.
A double-blind study was performed to compare the effects of a placebo, a topical corticosteroid, and a topical non-steroidal prostaglandin inhibitor on the inflammation and the course of intraocular pressure that follows cyclocryotherapy. Flurbiprofen 0.03%, dexamethasone phosphate 0.1%, and a sterile vehicle placebo were used both pre and postoperatively. Less anterior chamber flare was seen in flurbiprofen-treated eyes than those receiving placebo, but only at four weeks after surgery. More erythema was seen in flurbiprofen-treated eyes than in those receiving dexamethasone. Significance was approached showing more anterior chamber cells in placebo-treated eyes than in steroid-treated eyes. Cyclocryotherapy produces inflammation which is difficult to control with topically administered medications.
D000328:Adult; D000368:Aged; D000867:Anterior Chamber / Q000187:drug effects; D002986:Clinical Trials as Topic; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005480:Flurbiprofen / Q000494:pharmacology / Q000627:therapeutic use*; D005901:Glaucoma / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007249:Inflammation / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000188:drug therapy; D011422:Propionates / Q000627:therapeutic use*
D011422:Propionates; D005480:Flurbiprofen; D003907:Dexamethasone