The influence of insulin hypoglycemia on central dopaminergic structures of the rat.
Daily administration of insulin, 2 U/kg/day for 9 days, leads to a marked increase in the activity of central dopaminergic structures, reflected by an increase in the apomorphine or amphetamine-induced stereotypy and a decrease in fluphenazine-induced catalepsy. These changes are accompanied by a depression of cerebral dopamine and noradrenaline levels and a depression of noradrenaline utilization in the brain.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D002375:Catalepsy / Q000139:chemically induced; D005476:Fluphenazine / Q000494:pharmacology; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000503:physiopathology*; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects; D019805:alpha-Methyltyrosine
D007328:Insulin; D008781:Methyltyrosines; D011954:Receptors, Dopamine; D019805:alpha-Methyltyrosine; D000661:Amphetamine; D001058:Apomorphine; D005476:Fluphenazine