title: Significance of Chlamydia trachomatis in "abacterial" prostatitis.
abstract: Chlamydia (C.) trachomatis was isolated in McCoy cell cultures from urethral swabs after prostatic massage, of 43 out of 233 patients (18.5%) with symptoms of "abacterial" prostatitis, but also from 5 out of 65 control persons (7.7%). Numbers of granulocytes in sediments of cytocentrifuged urine voided after prostatic massage were normal (less than or equal to 2, magn. 400 X) in all 65 control persons, but were increased in 26 out of 43 patients with symptoms of "abacterial" prostatitis (greater than or equal to 4, magn. 400 X). Using an (H + L) chain specific anti-IgG FITC conjugate, microimmunofluorescence tests for detection of antibodies against C. trachomatis could be performed with the sera of all 65 control persons and with those of 37 out of the 43 patients. All control persons, even those five with positive C. trachomatis culture, were serologically negative (titer less than 1:8), while in 13 out of 15 C. trachomatis positive patients with a definitive diagnosis of "abacterial" prostatitis, humoral antibodies with titers of greater than or equal to 1:8, predominantly against serotypes I, J, E, and G, were detected. Serological results correlated well with granulocyte counts in urines after prostatic massage. Patients with symptoms of "abacterial" prostatitis with normal granulocyte counts (less than or equal to 2) and negative serology (titer less than 1:8) were considered suffering from "prostatodynia".
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis; D002692:Chlamydia trachomatis / Q000276:immunology / Q000302:isolation & purification*; D005455:Fluorescent Antibody Technique; D006098:Granulocytes / Q000166:cytology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011472:Prostatitis / Q000188:drug therapy / Q000276:immunology / Q000382:microbiology*; D013752:Tetracycline / Q000627:therapeutic use; D014521:Urethra / Q000382:microbiology; D014556:Urine / Q000166:cytology
chemical_list: D000907:Antibodies, Bacterial; D013752:Tetracycline