The main histocompatibility complex and ageing in mice and men.
Studies of the relationship between the main histocompatibility complex and survival into old age are reviewed. In mice there is some evidence that the H2 system is involved with longevity. Studies in very old humans may help to explain the survival of genes modulating different immune responsiveness.
D000375:Aging; D000818:Animals; D005260:Female; D006183:H-2 Antigens / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D007107:Immune System / Q000276:immunology; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice / Q000276:immunology*
D006183:H-2 Antigens; D006680:HLA Antigens; D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II