Reactions in selected patients to 22 fragrance materials.
182 patients on the basis of 6 criteria were suspected of suffering from contact sensitization to cosmetics. 77 (42%) gave a positive reaction to one or more of a series of 22 fragrance and flavor raw materials. The hands were most often involved. Cinnamic alcohol, hydroxycitronellal, eugenol, coumarin, and abitol gave the most common positive reactions; less frequent were cinnamic aldehyde, dihydrocoumarin and dimethylcitraconate. Their relevance could not be traced. However, the first 4 substances were the most frequently identified in 79 suspected cosmetics sent in for analysis by the patients or their physicians. The stability of room-stored petrolatum-fragrance mixtures should be checked.
D003358:Cosmetics / Q000009:adverse effects*; D003876:Dermatitis, Atopic / Q000209:etiology; D003877:Dermatitis, Contact / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D010328:Patch Tests; D010476:Perfume / Q000009:adverse effects*
D003358:Cosmetics; D010476:Perfume