Prostaglandin E1 in severe lower limb ischaemia: a double-blind controlled trial.
Thirty patients with ischaemic ulceration or rest pain due to lower limb atherosclerosis were treated with intravenous prostaglandin E1 (PGE1) or placebo in a prospective double-blind controlled trial. There was no significant improvement of rest pain, nor was PGE1 effective in promoting ulcer healing. This study provides no support for the use of intravenous PGE1 in the treatment of end-stage lower limb atherosclerotic disease.
D000328:Adult; D000368:Aged; D000527:Alprostadil; D001161:Arteriosclerosis / Q000188:drug therapy; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007511:Ischemia / Q000188:drug therapy*; D007866:Leg / Q000098:blood supply*; D007871:Leg Ulcer / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D011458:Prostaglandins E / Q000627:therapeutic use*; D011897:Random Allocation
D011458:Prostaglandins E; D000527:Alprostadil