title: [Evaluation of the photon correlation method of measuring skin blood flow and its use in the diagnosis of microcirculation disorders in patients with diabetes mellitus].
abstract: A new photon-correlation method for measuring blood flow and traditional methods for blood flow measurements according to the clearance of 133Xe were studied and compared. The measurement data of the skin circulation by the photon-correlation method and according to the clearance of 133Xe are in linear relationship, the correlation ratio being equal to +0.93 (P less than 0.01). At the same time the photon-correlation method has some advantages. Particularly it is marked by non-invasiveness, high accuracy, good reproducibility of the data and short exposure time. Photon-correlation spectroscopy was used to perform clinical studies of the skin circulation in different anatomic areas of the skin in diabetes mellitus patients. Altogether 117 subjects aged 19-60 years were examined. There were 38 healthy subjects and 79 patients with diabetes mellitus. The skin circulation was measured from the finger tip and from the internal surface of the upper third of the forearm. In healthy subjects, the skin circulation appeared substantially higher in the finger tip than in the forearm. In diabetes mellitus patients, the circulation in the finger skin was also higher than in the skin of the forearm. As compared to healthy subjects, the patients manifested a significant lowering in the finger circulation and only the tendency towards its decrease in the forearm.
mesh_terms: D000328:Adult; D003920:Diabetes Mellitus / Q000503:physiopathology*; D005069:Evaluation Studies as Topic; D005385:Fingers / Q000098:blood supply; D005542:Forearm / Q000098:blood supply; D006801:Humans; D008833:Microcirculation; D008875:Middle Aged; D011827:Radiation; D011865:Radioisotope Dilution Technique; D012039:Regional Blood Flow; D012867:Skin / Q000098:blood supply*; D013057:Spectrum Analysis / Q000379:methods*; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes
vernacular_title: Otsenka foton-korreliatsionnogo metoda izmereniia kozhnogo krovotoka i ego ispol'zovaniia v diagnostike narushenii mikrotsirkuliatsii u bol'nykh sakharnym diabetom.