title: Immunofluorescence studies of renal basement membranes in dogs with spontaneous diabetes.
abstract: Renal tissue from 12 dogs with spontaneous diabetes and 16 control dogs were studied by light, immunofluorescence, and electron microscopies. Significant linear staining for immunoglobulin G and albumin were observed in the glomerular and tubular basement membranes of dogs with spontaneous diabetes--similar to that observed in human diabetes. On immunohistochemical grounds, it would appear that the dog with spontaneous diabetes is an appropriate model of diabetes in persons.
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000473:pathology / Q000648:ultrastructure; D003920:Diabetes Mellitus / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005455:Fluorescent Antibody Technique; D007668:Kidney / Q000473:pathology* / Q000648:ultrastructure