Clinical comparison of thiothixene and thioridazine in schizophrenic adolescents.
Of 21 schizophrenic adolescents given thiothixene or thioridazine, many responded poorly or experienced sedation. Because sedation necessitates dose reductions, which limit therapeutic response, for schizophrenic adolescents high-potency neuroleptics may be preferable to the more sedating low-potency drugs.
D000293:Adolescent; D002648:Child; D002986:Clinical Trials as Topic; D004334:Drug Administration Schedule; D005260:Female; D006760:Hospitalization; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D012894:Sleep Stages; D013881:Thioridazine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D013888:Thiothixene / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D013888:Thiothixene; D013881:Thioridazine