Age related detection of tissue amyloid P in the skin.
The presence of tissue amyloid P component in normal skin from fetuses and children was studied using direct, fluorescent, immunohistochemical techniques on frozen sections. Tissue amyloid P is not detected in fetuses or in children up to the age of 2 years but from the age of 4 years upwards it is readily detected and invariably present. Though the function of human amyloid P is unknown its role appears to be age or maturity related.
D000293:Adolescent; D000367:Age Factors; D000682:Amyloid / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005333:Fetus / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D000683:Serum Amyloid P-Component; D012867:Skin / Q000032:analysis* / Q000196:embryology
D000682:Amyloid; D000683:Serum Amyloid P-Component