[Isolated liver perfusion in advanced metastases of colorectal cancers].
A special cannulation system was developed in order to completely isolate the liver in an extracorporeal circuit. Isolated hyperthermic liver perfusion at 40 degrees C with an average dosage of 1000 mg 5-FU was performed in 32 patients with liver metastases (29 colorectal carcinomas, 2 carcinoids, 1 primary hepatoma). 12 patients who had an overall 45% tumor invasion of the entire liver-volume as measured in CT-scan were treated exclusively by isolated liver perfusion. In that group median survival was 8 months and death occurred in the presence of extrahepatic metastases. Better results are achieved with isolated liver perfusion followed by intraarterial short-time infusions (Mitomycin C/5-FU) via an Implantofix catheter. Median actual survival in this group is 12 months, the longest follow-up period is 23 months.
D010478:Chemotherapy, Cancer, Regional Perfusion / Q000295:instrumentation; D003110:Colonic Neoplasms / Q000188:drug therapy*; D005472:Fluorouracil / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012004:Rectal Neoplasms / Q000188:drug therapy*
D005472:Fluorouracil
Die isolierte Leberperfusion bei fortgeschrittenen Metastasen kolorektaler Karzinome.