Endocrine changes with infusion of propionate in the dairy cow.
Sodium propionate (2.5 mmol/kg) was infused rapidly via a jugular vein into each of 13 multiparous Holstein cows at 7 wk postpartum for observation of clearance of propionate. Associated concentration changes of acetate and glucose in blood plasma and glucagon and insulin in blood serum were quantified. This dose elevated concentrations of propionate, which declined subsequently at an exponential rate (.108 min-1). Concentrations of glucagon and insulin were increased in the sampling immediately following infusion, yet subsequent decline of insulin concentrations acted to decrease the molar ratio of insulin:glucagon as propionate returned to preinfusion concentrations. Analysis of sample means disclosed a negative correlation -.82 between glucose and molar ratio of insulin:glucagon. These experimental observations suggest that a supraphysiological dose of propionate has an immediate effect on the pancreas to alter endocrine secretion in the lactating cow.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002417:Cattle / Q000378:metabolism*; D005260:Female; D005934:Glucagon / Q000097:blood*; D007263:Infusions, Parenteral / Q000662:veterinary; D007328:Insulin / Q000097:blood*; D007774:Lactation; D010179:Pancreas / Q000187:drug effects*; D011247:Pregnancy; D011422:Propionates / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*
D001786:Blood Glucose; D007328:Insulin; D011422:Propionates; D005934:Glucagon; C514135:sodium propionate; C029658:propionic acid