title: Ascending brain-stem noradrenergic pathways modulate the renin response to haemorrhage.
abstract: Ventral noradrenergic projections (VNAB) from lateral tegmental (A1, A2) and dorsal noradrenergic projections (DNAB) from the coeruleal (A6) as well as A1 cell groups in the brain-stem of the rat were lesioned by intracerebral injection of 6-hydroxydopamine. A marked increase in plasma renin activity and adrenaline concentrations followed haemorrhage (0.5 ml/100 g body weight) in the sham-operated rats. VNAB-lesioned rats showed a similar response to the sham-operated controls, but in DNAB-lesioned animals the rise of plasma renin was markedly attenuated.
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D001933:Brain Stem / Q000502:physiology*; D004837:Epinephrine / Q000097:blood; D006470:Hemorrhage / Q000097:blood / Q000503:physiopathology*; D008125:Locus Coeruleus / Q000502:physiology; D008297:Male; D008526:Medulla Oblongata / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D009638:Norepinephrine / Q000097:blood / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood / Q000378:metabolism*
chemical_list: D012083:Renin; D009638:Norepinephrine; D004837:Epinephrine