Use of LHRH agonists and antagonists in male contraception: a review.
Agonists and antagonists of LHRH have been shown to inhibit testicular function in animals and are considered to offer potential for nonsteroidal contraception. In men, they offer one of the few promising approaches to reversible suppression of spermatogenesis. They do, however, also depress testosterone synthesis, thus causing loss of libido, necessitating the administration of supplemental androgens.
D000818:Animals; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D004285:Dogs; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006801:Humans; D007985:Leydig Cells / Q000187:drug effects; D008253:Macaca mulatta; D008297:Male; D010903:Pituitary Gland, Anterior / Q000187:drug effects; D051381:Rats; D012671:Seminiferous Tubules / Q000187:drug effects; D013737:Testis / Q000187:drug effects*
D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D007987:Gonadotropin-Releasing Hormone