title: Cytotoxic chemotherapeutic agents under development with a possible future role in prostate cancer.
abstract: New cytotoxic chemotherapeutic compounds under development or in early clinical trial which might be considered for clinical evaluation in prostatic carcinoma are discussed. The following classes of agents are considered: lipid-soluble antifolates, anthracyclines, nitrosoureas, and platinum analogues. A group of miscellaneous compounds is also discussed.
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002945:Cisplatin / Q000627:therapeutic use; D004341:Drug Evaluation; D005493:Folic Acid Antagonists / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009279:Naphthacenes / Q000627:therapeutic use; D009607:Nitrosourea Compounds / Q000627:therapeutic use; D009944:Organoplatinum Compounds / Q000627:therapeutic use; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D012995:Solubility
chemical_list: D000903:Antibiotics, Antineoplastic; D000970:Antineoplastic Agents; D005493:Folic Acid Antagonists; D009279:Naphthacenes; D009607:Nitrosourea Compounds; D009944:Organoplatinum Compounds; D002945:Cisplatin