[Bacterial lipopolysaccharides: comparative analysis of the cardiovascular effects of E. coli, S. sonnei and Y. enterocolitica in anesthetized rats].
Intravenous injection of S. sonnei LPS (640 mcg/kg) and of Y. enterocolitica LPS (1280 mcg/kg) elicited a decrease in mean arterial pressure and heart rate in urethane anaesthetized rats. The bradycardia reached a maximum when hypotension had already reverted, thus suggesting direct and independent effects on the vessels and on the heart.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003864:Depression, Chemical; D004926:Escherichia coli; D006339:Heart Rate / Q000187:drug effects; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012764:Shigella sonnei; D015008:Yersinia enterocolitica
D008070:Lipopolysaccharides
Lipopolisaccaridi batterici: analisi comparativa degli effetti cardiovascolari di E. coli, S. sonnei e Y. enterocolitica in ratti anestetizzati.