title: [Changes in the physical load tolerance of stenocardia patients taking obzidan, korinfar and izoptin separately and together].
abstract: Changes in exercise tolerance under the impact of obsidan, corinfar, isoptin and their combinations were studied in 12 angina patients with the help of bicycle ergometry. The most marked increase in exercise tolerance following the use of a single drug was observed with obsidan (85.1 +/- 35.1%), although corinfar and isoptin also led to a significant elevation in the patients' working capacity (67.4 +/- 14.4% and 49.8 +/- 6.3%, respectively). Combination of isoptin and obsidan brought about no increase in tolerance as compared with obsidan alone whereas the combination of corinfar with obsidan showed the maximal antianginal effect.
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D004359:Drug Therapy, Combination; D005080:Exercise Test; D006801:Humans; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D010807:Physical Endurance / Q000187:drug effects*; D010919:Placebos; D011433:Propranolol / Q000627:therapeutic use*; D014700:Verapamil / Q000627:therapeutic use*
chemical_list: D002121:Calcium Channel Blockers; D010919:Placebos; D011433:Propranolol; D014700:Verapamil; D009543:Nifedipine
vernacular_title: Izmenenie tolerantnosti k fizicheskoĭ nagruzke u bol'nykh so stenocardieĭ pri razdel'nom i sochetannom primenenii obzidana, korinfara i izoptina.