title: Human chromosomal mapping of genes for insulin-like growth factors I and II and epidermal growth factor.
abstract: Many of the actions previously attributed to pituitary-derived growth hormone are mediated by polypeptide growth factors. These include the insulin-like growth factors I and II (IGF-I and IGF-II), which are members of the insulin family of proteins. We report here the chromosomal mapping of the human genes for IGF-I and IGF-II. IGF-II maps to the short arm of chromosome 11, which also contains the gene for insulin and the proto-oncogene c-Ha-ras1 (ref. 9). IGF-I maps to chromosome 12, which is evolutionarily related to chromosome 11 and carries the gene for the proto-oncogene c-Ki-ras2 (refs 10,44). We have also localized the human gene for an unrelated polypeptide hormone, epidermal growth factor, to chromosome 4q, in the same region as another specialized growth factor, T-cell growth factor. We speculate that these map assignments reflect the existence of gene families involved in growth control.
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002905:Chromosomes, Human, 4-5; D003001:Cloning, Molecular; D006224:Cricetinae; D003412:Cricetulus; D004815:Epidermal Growth Factor / Q000235:genetics*; D005796:Genes; D006801:Humans; D006822:Hybrid Cells / Q000378:metabolism; D007328:Insulin / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D010455:Peptides / Q000235:genetics*; D000090063:Proto-Oncogene Mas; D013002:Somatomedins / Q000235:genetics*
chemical_list: D007328:Insulin; C000715470:MAS1 protein, human; D010455:Peptides; D000090063:Proto-Oncogene Mas; D013002:Somatomedins; D004815:Epidermal Growth Factor