[Effect of luliberin and chorionic gonadotropin on luteinizing hormone and testosterone levels in the blood of monkeys under acute stress].
The effect of immobilization stress on luteinizing hormone (LH) and testosterone (T) secretion following injections of luliberin (LH-RH) and human chorionic gonadotropin (HCG) was investigated in male hamadryas baboons. It was established that in control animals a single injection of HCG (4500 IU) led to a more prolonged and more demonstrable increase of plasma testosterone concentration than injection of a pharmacological dose (100 micrograms) of LH-RH. Preliminary stimulation of the testes with LH-RH did not prevent the stress-induced inhibition of testosterone despite the fact that LH secretion in intact and stress-exposed baboons did not differ significantly over 2.5 h after drug injection. At the same time stress did not inhibit the testicular response in baboons pretreated with HCG (4500 IU), although the level of T concentration in stress-exposed animals was lower than in control. The data obtained suggest that disturbed interaction between hypophyseal tropic hormone and the testes underlie the inhibitory effect of stress.
D000208:Acute Disease; D000818:Animals; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006728:Hormones / Q000008:administration & dosage; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D010215:Papio; D012149:Restraint, Physical; D013268:Stimulation, Chemical; D013315:Stress, Psychological / Q000097:blood*; D013739:Testosterone / Q000097:blood*
D006063:Chorionic Gonadotropin; D006728:Hormones; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone
Vliianie liuliberina i khorionicheskogo gonadotropina na uroven' liuteiniziruiushchego gormona i testosterona v krovi u obez'ian v usloviiakh ostrogo stressa.