title: [Myocardial protection with cold blood potassium cardioplegia: experimental and clinical studies].
abstract: One hundred and eighty-one patients (101 men and 80 women) underwent 61 congenital and 120 acquired heart operations using cold blood potassium cardioplegia as the method of myocardial protection at Kagoshima University from August, 1978 to August, 1981. Hospital deaths occurred in 18 patients (9.8%), and 4 cases were late death (2.2%). Multivariate analysis revealed no significant relationship between type of heart disease and operative mortality or the occurrence of post-operative low output syndrome. To evaluate the superiority of cold blood cardioplegia for myocardial protection, we carried out 20 orthotopic heart transplants in dog; 16 transplanted grafts could maintain the circulation of recipient without cardiopulmonary bypass. Cardiac contractility following 90-minute ischemic time showed 97 to 100% of the control values without any inotropic drugs. These clinical and experimental findings suggest that cold blood potassium cardioplegia provides excellent myocardial protection during the ischemia of the heart.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D002303:Cardiac Output, Low / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D003080:Cold Temperature; D004285:Dogs; D005112:Extracorporeal Circulation; D005260:Female; D006324:Heart Arrest, Induced / Q000379:methods*; D006331:Heart Diseases / Q000601:surgery*; D016027:Heart Transplantation; D006439:Hemodynamics; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D011188:Potassium; D017680:Potassium Compounds
chemical_list: D017680:Potassium Compounds; C018369:potassium cardioplegic solution; D011188:Potassium