Combined effects of fast-neutron irradiation and subcutaneously applied carbon tetrachloride or chloroform in C57Bl6 mice.
Male and female C57Bl6 mice received a single whole-body dose of irradiation with 170 rad or 330 rad of fast neutrons. Nine weeks later they were given a single subcutaneous injection of carbon tetrachloride or chloroform. Chloroform did not influence the occurrence of tumours, but carbon tetrachloride markedly increased the incidence of radiation-induced liver carcinomas.
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002725:Chloroform / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005214:Fast Neutrons / Q000009:adverse effects; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced / Q000209:etiology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D014916:Whole-Body Irradiation
D002725:Chloroform; D002251:Carbon Tetrachloride