Insulin and glucagon infusion in the treatment of liver failure.
In an attempt to improve liver function and promote hepatic regeneration in a patient with severe liver injury, insulin alone or insulin and glucagon were administered by constant peripheral venous infusion during a 61-day period. The response, as assessed by a broad spectrum of hepato-cellular function tests, including synthetic, detoxification, bile metabolism, and microsomal enzyme function, and also histological evidence, indicated a beneficial effect. Continuous insulin and glucagon infusion merits further evaluation in the treatment of some forms of hepatic failure.
D000328:Adult; D000632:Aminopyrine; D001944:Breath Tests; D005260:Female; D005934:Glucagon / Q000627:therapeutic use*; D006501:Hepatic Encephalopathy / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D006801:Humans; D007263:Infusions, Parenteral; D007328:Insulin / Q000627:therapeutic use*; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications; D009336:Necrosis
D007328:Insulin; D000632:Aminopyrine; D005934:Glucagon