Glial fibrillary acidic protein (GFAP) in rat brain tumors transplacentally induced by ethylnitrosourea (ENU).
The immunohistochemical distribution of glial fibrillary acidic protein (GFAP) in neoplastic lesions induced in the rat by ENU is reported. GFAP was present in hypertrophic reactive astrocytes, which were numerous in early neoplastic proliferations, in microtumors of the white matter, and in those collected at the periphery of large tumors. They were absent in cortical oligodendroglial foci and microtumors. No GFAP-positive cells were observed in hyperplasias of the white matter: astrocyte-like cells of large tumors were GFAP-negative. The significance of reactive astrocytes and the problem of the astrocytic component in transplacental ENU tumors are discussed.
D000818:Animals; D001253:Astrocytes / Q000187:drug effects / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D001932:Brain Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D005038:Ethylnitrosourea / Q000633:toxicity*; D005260:Female; D005904:Glial Fibrillary Acidic Protein; D007124:Immunoenzyme Techniques; D007381:Intermediate Filament Proteins / Q000378:metabolism*; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D009607:Nitrosourea Compounds / Q000633:toxicity*; D009837:Oligodendroglioma / Q000139:chemically induced* / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D011916:Rats, Inbred F344
D005904:Glial Fibrillary Acidic Protein; D007381:Intermediate Filament Proteins; D009607:Nitrosourea Compounds; D005038:Ethylnitrosourea