Defective desaturation and elongation of n-6 and n-3 fatty acids in hypertensive patients.
Hypertensive patients had higher levels of linoleic acid (LA) in serum lipids than normal controls. Administration of large doses of LA failed to raise the percentage of its metabolite arachidonic acid (AA) in serum lipids. Similarly, intake of large amounts of alpha-linolenic acid (alpha-LNA) failed to increase the amount of eicosapentaenoic acid (EPA). The percentage of EPA in serum lipids could readily be increased by direct administration of comparably low doses in a mackerel diet. Hypertensive subjects seem to desaturate and elongate LA and alpha-LNA only very slowly.
D000818:Animals; D002788:Cholesterol Esters / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications; D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D005399:Fishes; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000150:complications; D019787:Linoleic Acid; D008041:Linoleic Acids; D008043:Linseed Oil; D008297:Male; D008460:Meat; D009821:Oils; D010938:Plant Oils; D012016:Reference Values; D000074242:Sunflower Oil; D014280:Triglycerides / Q000097:blood
D002788:Cholesterol Esters; D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D009821:Oils; D010938:Plant Oils; D000074242:Sunflower Oil; D014280:Triglycerides; D008043:Linseed Oil; D019787:Linoleic Acid