Recognition of host-membrane antigens in the envelope of measles virions.
Trypsin- and acetone-treated virions from either of two strains of measles virus grown in Vero cells stimulated the production in guinea pigs of (i) virus-specific antibodies to polypeptide (P) of molecular weight 70,000 (70K) and to the portion of the HA spike embedded in the viral envelope, but not to M protein, and (ii) antibodies to two host cell membrane antigens which were identified as glycoproteins with molecular weights of 108K and 104K. These host cell antigens were present in increased amounts in infected cells and were intimately associated with the virus. Untreated measles virions grown in Vero cells also stimulated the production of antibody to the 108K glycoprotein. The host polypeptides were less antigenic in virus derived from HEp2 cells, which apparently contained less of these antigens.
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis* / Q000276:immunology; D002460:Cell Line; D002522:Chlorocebus aethiops; D006801:Humans; D007158:Immunologic Techniques; D008459:Measles virus / Q000032:analysis* / Q000502:physiology; D013045:Species Specificity; D014759:Viral Envelope Proteins / Q000032:analysis* / Q000276:immunology; D014771:Virion / Q000032:analysis
D000954:Antigens, Surface; D014759:Viral Envelope Proteins