Cutaneous nonpulmonary Mycobacterium chelonei infection. Successful treatment with sulfonamides in an immunosuppressed patient.
A 52-year-old man, who had received immunosuppressive therapy for four years after renal transplantation, had a deep-set skin infection in his thigh caused by Mycobacterium chelonei. In vitro studies indicated that the organism was resistant to antimycobacterial agents but potentially sensitive to high-dose sulfonamide therapy. Repeated surgical excisions failed to eradicate the infection, as documented by histopathologic examination. The combination of a reduced dose of immunosuppressive medication and the administration of high-dose sulfonamide therapy resulted in clinical recovery.
D004338:Drug Combinations / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects; D007676:Kidney Failure, Chronic / Q000601:surgery; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009164:Mycobacterium Infections / Q000188:drug therapy*; D012874:Skin Diseases, Infectious / Q000188:drug therapy*; D013411:Sulfadiazine / Q000627:therapeutic use*; D013416:Sulfamerazine / Q000627:therapeutic use*; D013418:Sulfamethazine / Q000627:therapeutic use*; D013848:Thigh; D000096926:Benzenesulfonamides
D004338:Drug Combinations; D007166:Immunosuppressive Agents; D013411:Sulfadiazine; D013416:Sulfamerazine; D013418:Sulfamethazine; C014873:trisulfapyrimidine; D000096926:Benzenesulfonamides