title: Pathogenesis of the joint disease of rheumatoid arthritis.
abstract: The articular inflammation and joint destruction that characterizes rheumatoid arthritis is the result of a complex interaction between cellular elements--that is, inflammatory cells, immunologically competent cells, synovial lining cells--and their soluble byproducts. An understanding of these events must serve as the basis for rational treatment of the disease in the absence of knowledge about the inciting agent.
mesh_terms: D001172:Arthritis, Rheumatoid / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D001402:B-Lymphocytes / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007074:Immunoglobulin G / Q000032:analysis; D007592:Joint Diseases / Q000209:etiology*; D013583:Synovial Membrane / Q000473:pathology / Q000648:ultrastructure; D013585:Synovitis / Q000209:etiology; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D007074:Immunoglobulin G