Organ-specific adhesion of metastatic tumor cells in vitro.
Binding of tumor cells to cryostat sections of host organs was studied. B16-F10 melanoma cells and reticulum cell sarcoma cells demonstrated an organ specificity in their binding in vitro that reflected the organ specificity of their metastatic distribution 25 days after intravenous injection. These results provide evidence for specific binding of tumor cells to the tissues that they selectively colonize in vivo.
D000268:Adhesiveness; D000818:Animals; D002460:Cell Line; D006801:Humans; D008099:Liver / Q000503:physiopathology; D008168:Lung / Q000503:physiopathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000503:physiopathology; D008545:Melanoma / Q000503:physiopathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis / Q000503:physiopathology; D009369:Neoplasms / Q000503:physiopathology*; D009374:Neoplasms, Experimental / Q000503:physiopathology; D009928:Organ Specificity