Drug metabolism in spontaneously diabetic guinea pigs.
Both sexes of spontaneously diabetic guinea pigs exhibit hyperinsulinemia (greater than 4-fold normal). This diabetic state is associated with the inhibition of hepatic drug metabolism in males but not females.
D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005260:Female; D006168:Guinea Pigs; D007328:Insulin / Q000097:blood; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D012737:Sex Factors
D000814:Aniline Compounds; D007328:Insulin; D004364:Pharmaceutical Preparations; D000632:Aminopyrine; C023650:aniline