Estradiol application to one striatum produces postural deviation to systemic apomorphine.
In order to test whether estrogen acts directly in the dorsal striatum to affect dopamine-mediated behavior, ovariectomized female Long-Evans rats were given a unilateral striatal application of estradiol, injected systemically with apomorphine (APO), and tested for lateralization of stereotypic behaviors. In the first experiment, estradiol, cholesterol, or an empty cannula was inserted and the rat given 0.7 mg/kg APO 1-4 hours later. Rats directed their stereotypic behaviors to the side ipsilateral to the insert of estradiol with dorsal striatal inserts, but not with inserts in ventral striatum or neocortex. Neither cholesterol nor the empty cannula inserts were effective in producing lateralization of the stereotypic behaviors. In the second experiment, intrastriatal inserts of 17 alpha-estradiol were ineffective in producing a lateralization of APO-induced stereotyped behavior. In the third experiment, several doses of APO (0.07, 0.75 and 3.0 mg/kg) were tested. At the highest dose no lateralization of APO-induced stereotypic behavior was observed. These results strongly suggest that estradiol acts directly in the dorsal striatum to antagonize APO and thus produce a lateralization of stereotypic behaviors (postural deviation).
D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D002369:Castration; D002404:Catheterization; D002784:Cholesterol / Q000008:administration & dosage / Q000494:pharmacology; D003342:Corpus Striatum / Q000502:physiology*; D004298:Dopamine / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D011187:Posture; D051381:Rats; D013238:Stereotaxic Techniques; D013239:Stereotyped Behavior / Q000187:drug effects*
D004958:Estradiol; D002784:Cholesterol; D001058:Apomorphine; D004298:Dopamine