Testing of 2,4,5-T-amino acid conjugates for mutagenic activity in Salmonella typhimurium strains.
Since amino acid conjugates are plant metabolites of the herbicide 2,4,5-trichlorophenoxyacetic acid (2,4,5-T), 5 amino acid conjugates (aspartic acid, glutamic acid, leucine, methionine and tryptophan) of 2,4,5-T were tested for possible mutagenic activity utilizing 5 strains of Salmonella typhimurium (TA97, TA98, TA100, TA1535 and TA1538) with and without rat-liver microsomal and cytosolic enzymes. These compounds did not cause any significant increase in reversions when compared with controls in the presence or absence of the activating system. Further, linear regression analysis showed no significant (p less than 0.05) dose-response relationships. Thus, it was concluded that the tested amino acid conjugates of 2,4,5-T are not mutagens or promutagens in these assays.
D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D000596:Amino Acids / Q000633:toxicity*; D000818:Animals; D001711:Biotransformation; D003600:Cytosol / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects; D013045:Species Specificity; D013329:Structure-Activity Relationship
D000596:Amino Acids; D009153:Mutagens; D015085:2,4,5-Trichlorophenoxyacetic Acid