[Effect of insulin and hydrocortisone on various indices of energy metabolism in rats irradiated with 6.0 MeV fast neutrons].
Neutron irradiation (1 Gy, 0.5 + 0.5 Gy) causes hypersecretion of glucocorticoids. The administration of hydrocortisone imitates, in intact rats, and increases, in irradiated rats, the radiation inhibition of energy metabolism. The increase of radical oxidation in irradiated tissues is a probable cause of radiation hypercorticism; glucocorticoids are the inhibitors of radical oxidation. Insulin injections to irradiated rats normalize the main indices of energy metabolism.
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism; D005214:Fast Neutrons; D006854:Hydrocortisone / Q000494:pharmacology / Q000502:physiology*; D007328:Insulin / Q000494:pharmacology / Q000502:physiology*; D008054:Lipid Peroxides / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D010085:Oxidative Phosphorylation; D011833:Radiation Injuries, Experimental / Q000378:metabolism*; D051381:Rats
D000227:Adenine Nucleotides; D007328:Insulin; D008054:Lipid Peroxides; D006854:Hydrocortisone
Vliianie insulina i gidrokortizona na nekotorye pokazateli énergeticheskogo obmena u krys, obluchennykh bystrymi neĭtronami s énergieĭ 6,0 MéV.