Development of GABAergic neurons in rat visual cortex as identified by glutamate decarboxylase-like immunoreactivity.
The development of glutamate decarboxylase (GAD)-like immunoreactivity was studied in albino rats. GAD-positive structures appeared and accumulated in a characteristic temporo-spatial sequence: from embryonic day 18 onwards in lamina (L) I and subplate; after birth in L I-II, L IV-V and deep L VI including white matter; after two weeks in superficial L I, L II to L III-IV border, L V and L VI-white matter. GAD-positive axon varicosities formed perisomatic 'baskets' on L V pyramids on postnatal day 8 and a few days later on those L II-III. During the third week GAD-positive structures attained adult densities and established different laminar patterns in the primary and secondary visual areas.
D000818:Animals; D001369:Axons / Q000201:enzymology; D002454:Cell Differentiation; D003712:Dendrites / Q000201:enzymology; D005260:Female; D005865:Gestational Age; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D007124:Immunoenzyme Techniques; D009474:Neurons / Q000166:cytology; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014793:Visual Cortex / Q000166:cytology*; D014795:Visual Pathways / Q000166:cytology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase