Betaxolol and timolol. A comparison of efficacy and side effects.
Betaxolol hydrochloride, 0.5%, and timolol maleate, 0.5%, were compared in a 26-week randomized, double-masked study involving 46 patients with primary open-angle glaucoma. The two drugs were comparable with regard to both intraocular pressure-lowering efficacy and side effects. Since betaxolol is a selective beta 1-adrenergic antagonist, it may be advantageous for patients in whom beta 2-blockade could be harmful.
D000368:Aged; D015784:Betaxolol; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011412:Propanolamines / Q000009:adverse effects / Q000627:therapeutic use*; D011446:Prospective Studies; D011674:Pulse / Q000187:drug effects; D013999:Timolol / Q000009:adverse effects / Q000627:therapeutic use*
D009883:Ophthalmic Solutions; D011412:Propanolamines; D013999:Timolol; D015784:Betaxolol