Magnesium selectively inhibits N-methyl-aspartic acid-induced hypermotility after intra-accumbens injection.
The excitatory amino acids, N-methyl-aspartic acid, kainic acid and quisqualic acid have been shown to produce a marked increase in locomotor activity after bilateral injection into the rat nucleus accumbens. The intra-accumbens injection of magnesium inhibited the hypermotility response produced by N-methyl-aspartic acid in a dose-dependent manner. However, magnesium had no significant inhibitory effect on the increase in motility produced by either kainic acid or quisqualic acid. In contrast to magnesium, calcium produced a weak inhibitory action on N-methyl-aspartic acid-induced hypermotility. These data suggest that in the nucleus accumbens, at least two receptor types (N-methyl-aspartic acid/magnesium-sensitive and non-N-methyl-aspartic acid/magnesium-insensitive receptors) are present which can mediate the stimulation of locomotor activity produced by excitatory amino acids.
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors; D002122:Calcium Chloride / Q000494:pharmacology; D007267:Injections; D007608:Kainic Acid / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D016202:N-Methylaspartate; D009714:Nucleus Accumbens; D010069:Oxadiazoles / Q000494:pharmacology; D016318:Quisqualic Acid; D051381:Rats; D011919:Rats, Inbred Strains
D010069:Oxadiazoles; D001224:Aspartic Acid; D016202:N-Methylaspartate; D016318:Quisqualic Acid; D008274:Magnesium; D002122:Calcium Chloride; D007608:Kainic Acid