[Comparative study of the effectiveness of korinfar, izoptin and obzidan in patients with variant stenocardia combined with effort stenocardia].
Twelve patients with variant angina combined with angina of effort were examined. Repeated exercise tests prior to the administration of antianginal drugs revealed the spontaneous variability of the patients' tolerance to the exercise and of the pulse-pressure index at the exercise peak which may serve as an indirect sign of the angiospastic factor involvement in clinical manifestations of angina of effort. The treatment of such patients with corinfar and isoptin was associated with the elimination and significant reduction of spontaneous attacks of angina attended by a considerable increase in the exercise tolerance and in the pulse-pressure index at the exercise peak. The treatment with obsidan in these cases was less effective: the incidence of spontaneous anginal attacks changed insignificantly, the tolerance to exercise increased with the reduction of the maximum value of the pulse-pressure index.
D000328:Adult; D000787:Angina Pectoris / Q000175:diagnosis / Q000188:drug therapy*; D000788:Angina Pectoris, Variant / Q000175:diagnosis / Q000188:drug therapy*; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003329:Coronary Vasospasm / Q000175:diagnosis; D004311:Double-Blind Method; D004562:Electrocardiography; D005080:Exercise Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use*; D014700:Verapamil / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D011433:Propranolol; D014700:Verapamil; D009543:Nifedipine
Sravnitel'noe izuchenie éffektivnosti korinfara, izoptina i obzidana u bol'nykh s variantnoĭ stenokardieĭ, sochetaiushcheĭsia so stenokardieĭ napriazheniia.