[Method of automated cytomorphological analysis for classifying leukocytes by their stage of destruction].
Destruction of human peripheral blood leukocytes by toxins has been studied with the aid of an automatic microimage analyzer the "Morphoquant". The most informative parameters which define destruction stages have been revealed: the area and number of fragments of nucleus images and their distance to the nucleus centre under different levels of the optical threshold. Software for morphological analysis of leukocytes has been developed in addition to their classification using four destruction stages. The results of computerized classification of blood smears will compare with those obtained by a working haemotologist (85% coincidence).
D001322:Autoanalysis / Q000295:instrumentation; D003584:Cytological Techniques / Q000295:instrumentation; D006801:Humans; D007962:Leukocytes / Q000145:classification* / Q000187:drug effects; D008905:Minicomputers; D014115:Toxemia / Q000097:blood; D014118:Toxins, Biological / Q000633:toxicity
D014118:Toxins, Biological
Metod avtomatizirovannogo tsitomorfologicheskogo analiza dlia klassifikatsii leĭkotsitov po stadiiam destruktsii.