Prevention of gastric mucosal lesions in rats by tri-potassium di-citrato bismuthate.
Tri-potassium di-citrato bismuthate given intragastrically to rats 60 min before administration of necrotizing agents such as 85% ethanol, 0.2 N sodium hydroxide or acidified indomethacin, reduced the formation of mucosal lesions dose-dependently. Prostaglandin I2 (PGI2)-like material, determined by bioassay, was higher in the gastric mucosa of animals treated with bismuth subcitrate complex than in control animals.
D000818:Animals; D000897:Anti-Ulcer Agents; D001729:Bismuth / Q000494:pharmacology*; D011464:Epoprostenol / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009942:Organometallic Compounds; D051381:Rats; D011919:Rats, Inbred Strains; D012972:Sodium Hydroxide / Q000494:pharmacology; D013276:Stomach Ulcer / Q000139:chemically induced
D000897:Anti-Ulcer Agents; D009942:Organometallic Compounds; D000431:Ethanol; D012972:Sodium Hydroxide; D011464:Epoprostenol; C002791:bismuth tripotassium dicitrate; D001729:Bismuth; D007213:Indomethacin