Actin and coordination of metabolic processes.
The current data on actin content in muscles and non-muscle cells were analyzed. It was demonstrated that actin is present in large amounts in all living cells. Study of actin interaction with different enzymes is of particular interest. A concept has been put forward, which is based on our experimental data and on the data obtained in other laboratories concerning the effects of F-actin on kinase phosphorylase, glyceraldehyde phosphate dehydrogenase and lactate dehydrogenase. According to this concept, actin is a protein which coordinates metabolic processes.
D000199:Actins / Q000502:physiology*; D000818:Animals; D003599:Cytoskeleton / Q000502:physiology; D003850:Deoxyribonuclease I / Q000037:antagonists & inhibitors; D004789:Enzyme Activation; D004798:Enzymes / Q000378:metabolism*; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006019:Glycolysis; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D046911:Macromolecular Substances; D008854:Microscopy, Electron; D009132:Muscles / Q000502:physiology; D009218:Myosins / Q000378:metabolism; D010764:Phosphorylase Kinase / Q000378:metabolism; D014018:Tissue Distribution
D000199:Actins; D004798:Enzymes; D046911:Macromolecular Substances; D006003:Glycogen; D007770:L-Lactate Dehydrogenase; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D010764:Phosphorylase Kinase; D003850:Deoxyribonuclease I; D009218:Myosins; D005634:Fructose-Bisphosphate Aldolase