Effect of pectin on gastric emptying and gut hormone release in the dumping syndrome.
The effect of pectin on gastric emptying, gut hormone release, and symptoms was studied in four patients with dumping syndrome and in two healthy volunteers after ingestion of a hypertonic glucose meal with and without addition of pectin. The initial fraction emptied from the stomach was reduced in the patients, whose symptoms of dumping were abolished or alleviated by pectin. This change of the emptying seems to be caused by a prolonged stomach transit, probably due to the viscous nature of the pectin meal. Pectin had no effect on the gastric emptying of the volunteers. The motor activity of the stomach was not altered by pectin in either the patients or volunteers. In the patients insulin, enteroglucagon, neurotensin, and gastric inhibitory polypeptide rose to higher levels after the glucose meal than after the glucose-pectin meal. The individual differences in the hormone release were considered secondary to the altered gastric emptying produced by pectin.
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D004377:Dumping Syndrome / Q000503:physiopathology*; D005260:Female; D005746:Gastric Emptying; D005749:Gastric Inhibitory Polypeptide / Q000378:metabolism; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D004763:Glucagon-Like Peptides / Q000378:metabolism; D005950:Glucose Solution, Hypertonic / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D008875:Middle Aged; D009037:Motilin / Q000378:metabolism; D009496:Neurotensin / Q000378:metabolism; D010368:Pectins / Q000494:pharmacology*
D001786:Blood Glucose; D005768:Gastrointestinal Hormones; D005950:Glucose Solution, Hypertonic; D007328:Insulin; D009496:Neurotensin; D009037:Motilin; D005749:Gastric Inhibitory Polypeptide; D004763:Glucagon-Like Peptides; D010368:Pectins