Immunofluorescence studies of renal basement membranes in dogs with spontaneous diabetes.
Renal tissue from 12 dogs with spontaneous diabetes and 16 control dogs were studied by light, immunofluorescence, and electron microscopies. Significant linear staining for immunoglobulin G and albumin were observed in the glomerular and tubular basement membranes of dogs with spontaneous diabetes--similar to that observed in human diabetes. On immunohistochemical grounds, it would appear that the dog with spontaneous diabetes is an appropriate model of diabetes in persons.
D000818:Animals; D001485:Basement Membrane / Q000473:pathology / Q000648:ultrastructure; D003920:Diabetes Mellitus / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005455:Fluorescent Antibody Technique; D007668:Kidney / Q000473:pathology* / Q000648:ultrastructure