Standardization of anaesthesia for radiorenography with primates under laboratory conditions.
The influence of thiopentone intravenous infusion or halothane inhalation on the results of radiorenography was evaluated using, in six chacma baboons (Papio ursinus), 99mTc-diethyltriamine-pentaacetic acid (DTPA) as scanning agent. The renogram parameters, which depend on the condition of the cardiovascular system, differed significantly for the two anaesthetic agents. Since anaesthesia is necessary in baboon studies for the duration of renogram acquisition, it is imperative to standardize an experimental procedure which will leave the cardiovascular system relatively stable. From this investigation it seemed most appropriate to use as an anaesthetic a constant intravenous infusion of thiopentone.
D000769:Anesthesia, Inhalation / Q000592:standards / Q000662:veterinary*; D000771:Anesthesia, Intravenous / Q000592:standards / Q000662:veterinary*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006221:Halothane / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D010215:Papio / Q000502:physiology; D004369:Pentetic Acid; D011866:Radioisotope Renography / Q000592:standards / Q000662:veterinary*; D013667:Technetium; D016284:Technetium Tc 99m Pentetate; D013874:Thiopental / Q000494:pharmacology
D007649:Ketamine; D013667:Technetium; D004369:Pentetic Acid; D013874:Thiopental; D006221:Halothane; D016284:Technetium Tc 99m Pentetate