title: Esophageal cryptococcosis in a patient with the hyperimmunoglobulin E-recurrent infection (Job's) syndrome.
abstract: Patients with the hyperimmunoglobulin E-recurrent infection (Job's) syndrome, which is characterized by an elevated immunoglobulin E level, recurrent staphylococcal infections, and an abnormality of neutrophil chemotaxis, have been reported to have visceral Candida infections in addition to their more frequent pyogenic infections. We report a patient with Job's syndrome who presented with massive hematemesis secondary to esophageal cryptococcosis. A thorough evaluation for an occult neoplasm or extraesophageal cryptococcosis was negative. The patient received a 6-wk course of amphotericin B (970 mg) and 5-fluorocytosine with complete radiographic and endoscopic resolution of the lesion. He is doing well 18 mo after therapy. The patient was not anergic, and his response to T-cell mitogens, helper-to-suppressor T-cell ratio, total number of T cells, and immunoglobulin-producing capability were all normal. This case is unusual in that it is the first documentation of a cryptococcoma of the esophagus and underscores the importance of culturing abnormal specimens for unsuspected pathogens in unusual clinical circumstances.
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D003453:Cryptococcosis / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D003455:Cryptococcus neoformans / Q000302:isolation & purification; D004724:Endoscopy; D004935:Esophageal Diseases / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D007589:Job Syndrome / Q000150:complications*; D008297:Male; D010585:Phagocyte Bactericidal Dysfunction / Q000150:complications*
chemical_list: D000666:Amphotericin B; D005437:Flucytosine