title: The form and structure of supernumerary hindlimbs formed following skin grafting and nerve deviation in the newt Triturus cristatus.
abstract: The results of a series of skin grafting experiments performed on the hindlimb of the newt Triturus cristatus are described. In an attempt to limit the position of origin and the complexity of supernumerary limb outgrowths four experimental features were varied. These were 1) size of skin grafts; 2) their position of origin; 3) the position to which they were grafted; and 4) the presence or absence of nerves of two different sizes at the graft site. The degree of distal outgrowth and the pattern of the supernumerary structures in the anterior to posterior and dorsal to ventral axes were assessed. The results are discussed in terms of the control of pattern regulation in localized populations of limb blastema cells.
mesh_terms: D000818:Animals; D005260:Female; D006614:Hindlimb / Q000254:growth & development* / Q000294:innervation; D008297:Male; D009024:Morphogenesis; D012584:Sciatic Nerve / Q000502:physiology; D012867:Skin / Q000294:innervation; D016038:Skin Transplantation; D014319:Triturus / Q000502:physiology*