Identification of low-frequency modes in protein molecules.
It is demonstrated that the observed low-frequency motions with wave numbers of 22 cm-1 and 25 cm-1 for insulin and lysozyme respectively originate from the accordion-like motions of the principal helices therein. The calculated results based on such a model are in good agreement with the observed values. During calculations the role of the internal microenvironment upon the low-frequency motion is naturally revealed, so as to elucidate as well why this kind of low-frequency motion is so sensitive to the conformations of proteins observed.
D007328:Insulin; D008958:Models, Molecular; D009038:Motion; D009113:Muramidase; D011487:Protein Conformation
D007328:Insulin; D009113:Muramidase