Immunoscintigraphy in human squamous lung cancer using monoclonal antibodies.
We describe immunoscintigraphy using a radiolabelled anti-tumor monoclonal antibody 181-23 in 6 patients with squamous lung cancer. Double-label method using simultaneous injections of 131I MAB and 125I control immunoglobulin was performed to evaluate the specificity of MAB localization in the tumor. Immunohistological localization of MAB in resected specimen was obtained by immunoperoxidase technique. All our data are negative but correlated.
D000368:Aged; D000818:Animals; D000911:Antibodies, Monoclonal; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D007074:Immunoglobulin G / Q000032:analysis; D007457:Iodine Radioisotopes; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology; D051379:Mice; D008875:Middle Aged; D011877:Radionuclide Imaging
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D007457:Iodine Radioisotopes