title: [Experimental analysis and planning using the Salmonella/microsomes test].
abstract: A possible statistical treatment of the results obtained in Salmonella typhimurium TA1950, TA1535, TA1537, TA1538, TA98 and TA100 using the Salmonella/microsomes test was investigated. An analysis of independent repeated experiments pointed to the divergence of the data obtained. Consequently, it has been recommended to carry out the statistical treatment of experimental data within the limits of dispersion analysis with the subsequent use of the Scheffe's method for multiple comparisons. To stabilize the dispersion of experimental data, it is suggested to express the number of revertant colonies as lnX. A minimal volume of the data sample needed for resolving experimental tasks has been calculated. In standard experiments aimed at revealing the mutagenic activity of the compounds used, three Petri dishes should be used in each variant of experiments.
mesh_terms: D008861:Microsomes / Q000187:drug effects*; D009152:Mutagenicity Tests / Q000379:methods*; D012107:Research Design; D012486:Salmonella typhimurium / Q000187:drug effects* / Q000235:genetics; D013223:Statistics as Topic
vernacular_title: Analiz i planirovanie éksperimentov s ispol'zovaniem testa Salmonella/mikrosomy.