title: Suppression and enhancement of transformation of ferret peripheral blood mononuclear cells by mycobacteria.
abstract: The effect of heat killed Mycobacterium bovis on the phytohaemagglutinin (PHA) response of normal peripheral blood leucocytes from ferrets was dose dependent. Concentrations of 10(6) organisms ml-1 and below enhanced the response, whereas more than 10(6) organisms ml-1 suppressed it. This suppression correlated with cytotoxicity of M bovis for ferret peripheral blood leucocytes. Three environmental strains, M phlei, M smegmatis and M aurum were not cytotoxic and did not affect the PHA response but were found to be mitogenic at high concentrations.
mesh_terms: D000818:Animals; D002335:Carnivora / Q000276:immunology*; D005289:Ferrets / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D009161:Mycobacterium / Q000276:immunology*; D009163:Mycobacterium bovis / Q000276:immunology*; D009170:Nontuberculous Mycobacteria / Q000276:immunology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013045:Species Specificity
chemical_list: D010835:Phytohemagglutinins