The effect of drugs on serum histidine levels in rheumatoid arthritis.
Groups of 15 patients with active rheumatoid arthritis were treated for 24 weeks with zinc sulphate, trien, captopril, clozic in two doses or a combination of D-penicillamine and hydroxychloroquine. Serum histidine levels were monitored along with measures of disease activity including C-reactive protein, plasma viscosity, articular index, grip strength and early morning stiffness. Zinc sulphate and trien were found to be ineffective while the other drugs all showed evidence of second-line action. Serum histidine was found to improve during successful therapy. The possible cause of low serum histidine and its response to therapy is discussed.
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy*; D002216:Captopril / Q000627:therapeutic use; D002994:Clofibrate / Q000031:analogs & derivatives / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D006639:Histidine / Q000097:blood*; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000627:therapeutic use; D013431:Sulfates / Q000627:therapeutic use; D014266:Trientine / Q000627:therapeutic use; D015032:Zinc / Q000627:therapeutic use; D019287:Zinc Sulfate
D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D013431:Sulfates; D006639:Histidine; D006886:Hydroxychloroquine; D019287:Zinc Sulfate; D002216:Captopril; D010396:Penicillamine; D002994:Clofibrate; D015032:Zinc; D014266:Trientine; C018431:clobuzarit