[Effect of the amoxicillin-gentamicin combination in the presence of clavulanic acid on 8 strains of amoxicillin-resistant bacteria].
The in vitro inhibitory activity of a combination of amoxicillin and gentamicin was assayed by the microdilution technique in liquid medium on 8 amoxicillin-resistant strains, with the addition of clavulanic acid at a concentration of 4 micrograms/ml. A synergistic effect was demonstrated when clavulanic acid was added. The FIC index was particularly low for the 2 Staphylococcus aureus strains tested (0.19 and 0.25), and slightly higher for the 2 Escherichia coli (0.25 and 0.5) and 2 Proteus vulgaris (0.5 and 0.5) strains. Synergism was less apparent for the 2 Klebsiella pneumoniae strains tested (0.63 and 0.75). Without clavulanic acid, a synergistic effect was found on only three strains: one Staphylococcus aureus, one Klebsiella and one Proteus. However, the high levels of MICs at which these effects were observed preclude the clinical usefulness of the association. We conclude that the synergistic effect of the amoxicillin-gentamicin combination on susceptible strains is confirmed on amoxicillin-resistant strains when clavulanic acid is added.
D000658:Amoxicillin / Q000494:pharmacology*; D002969:Clavulanic Acids / Q000494:pharmacology*; D004338:Drug Combinations; D004926:Escherichia coli / Q000187:drug effects; D005839:Gentamicins / Q000494:pharmacology*; D007711:Klebsiella pneumoniae / Q000187:drug effects; D010403:Penicillin Resistance; D011514:Proteus vulgaris / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
D002969:Clavulanic Acids; D004338:Drug Combinations; D005839:Gentamicins; D000658:Amoxicillin
Effet de l'association amoxicilline-gentamicine en présence d'acide clavulanique sur huit souches bactériennes résistantes à l'amoxicilline.