Reverse cellular distribution of calmodulin to S-100 protein in primate brain.
Both calmodulin and S-100 protein are Ca2+-binding proteins of the EF-hand family. Immunocytochemical study revealed that calmodulin existed mainly in the neurons, whereas S-100 protein was localized primarily in the glial cells of the cerebral and cerebellar cortices of man and monkey. The observed reverse cellular distribution of calmodulin to S-100 protein in primate brain suggests that calmodulin might be replaced in its role as a Ca2+-binding protein by S-100 protein in the glial cells.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism*; D002525:Cerebellar Cortex / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism; D005625:Frontal Lobe / Q000378:metabolism; D006801:Humans; D007124:Immunoenzyme Techniques; D008251:Macaca; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D011689:Purkinje Cells / Q000378:metabolism; D009418:S100 Proteins / Q000378:metabolism*
D002147:Calmodulin; D009418:S100 Proteins