title: The ethanol withdrawal syndrome: a consequence of lack of substrate for a cerebral Krebs-cycle.
abstract: The hypothesis is advanced that the ethanol withdrawal syndrome is a manifestation of dependence by a cerebral Krebs-cycle on substrates which are readily available during ethanol addiction but which are relatively unavailable during withdrawal.
mesh_terms: D020155:3-Hydroxybutyric Acid; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002087:Butyrates / Q000378:metabolism; D002952:Citric Acid Cycle; D000431:Ethanol / Q000009:adverse effects*; D006801:Humans; D006885:Hydroxybutyrates / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D051381:Rats; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000378:metabolism*
chemical_list: D002087:Butyrates; D006885:Hydroxybutyrates; D007773:Lactates; D000431:Ethanol; D020155:3-Hydroxybutyric Acid