Serum level of complement factor D in systemic lupus erythematosus--an indicator of glomerular filtration rate.
Serum levels of complement factor D, a low molecular weight (LMW) protein, were high and inversely correlated with glomerular filtration rate (GFR) determined in 19 patients with lupus glomerulonephritis (LGN). Factor D was significantly closer correlated with S-creatinine than were two other LMW proteins, beta 2-microglobulin and gamma-trace in 22 LGN patients. Close correlations between each of the LMW proteins and S-creatinine were found in patients with a non-inflammatory disorder, polycystic kidney disease. Slightly increased beta 2-microglobulin concentrations were found in 15 of 20 systemic lupus erythematosus (SLE) patients without renal involvement, while factor D and gamma-trace showed normal values in most of these patients. The findings imply that serum concentrations of complement factor D in SLE are mainly determined by the GFR.
D000293:Adolescent; D000328:Adult; D002648:Child; D003166:Complement Activating Enzymes / Q000032:analysis*; D011416:Complement Factor D / Q000032:analysis*; D003404:Creatinine / Q000097:blood; D055316:Cystatin C; D015891:Cystatins; D005260:Female; D005919:Glomerular Filtration Rate; D005921:Glomerulonephritis / Q000097:blood*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D007690:Polycystic Kidney Diseases / Q000097:blood; D011506:Proteins / Q000032:analysis; D001613:beta 2-Microglobulin / Q000032:analysis
C525030:CST3 protein, human; D055316:Cystatin C; D015891:Cystatins; D011506:Proteins; D001613:beta 2-Microglobulin; D003404:Creatinine; D003166:Complement Activating Enzymes; C493488:CFD protein, human; D011416:Complement Factor D