[Initial treatment of the early manifestations of diabetes mellitus type I with a mixture of insulins].
From 1977-1982 47 patients with newly diagnosed type I diabetes mellitus were treated in the department of Pediatrics, University of Ulm . 34 patients had no ketoacidosis. They were treated initially with 1 U/kg bodyweight/day of insulin as a mixture of 1/3 regular and 2/3 NPH. In the morning they received 2/3 and in the evening 1/3 of the total amount of insulin. 13 patients with ketoacidoses initially were treated for 12-36 h with regular insulin either subcutaneously or intravenously and later with the insulin mixture as outlined above. 37 patients received purified porcine and 10 patients biosynthetic human insulin (BHI). The non ketotic patients reached a good metabolic control (= mean blood glucose less than 150 mg/dl) on day 3.1 +/- 1.9 with porcine and on day 2.8 +/- 1.4 with human insulin (M +/- SD). Excellent metabolic control (= all blood glucose concentrations less than 150 mg/dl) was achieved with procine insulin on day 4.6 +/- 1.7 and with BHI on day 4.3 +/- 1.5. 2.6% of 1916 blood glucose determinations ranged less than 50 mg/dl, minimal value: 31 mg/dl. Severe symptomatic hypoglycemias were not observed. All ketoacidotic patients were treated with porcine insulin. They reached good metabolic control on day 6.0 +/- 2.3 and excellent metabolic control on day 7.9 +/- 3.5. It appears that newly diagnosed insulin-dependent-diabetic patients without ketoacidosis can be managed quickly and safely with a mixture of regular and NPH insulin from the very beginning of the disease.
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D004338:Drug Combinations; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000096:biosynthesis / Q000627:therapeutic use*; D013552:Swine
D004338:Drug Combinations; D007328:Insulin
Initialbehandlung der Erstmanifestation des Diabetes mellitus Typ I mit Mischinsulin.