Immunohistochemical study of fibronectin in hemangioblastomas and hemangiopericytomas.
Eight hemangioblastomas and two hemangiopericytomas were studied using indirect immunoperoxidase stains for fibronectin (FN) and glial fibrillary acidic protein (GFAP) in formalin-fixed, paraffin-embedded surgical specimens. Stromal cells in hemangioblastomas were GFAP-negative and showed variable FN expression, while GFAP-positive cells were FN-negative, thus suggesting that the stromal cells are not derived from astrocytes. Hemangiopericytoma cells were poorly to intermediately FN-positive. The origin of stromal cells is discussed in the light of their fine structure and the immunohistochemical stains with other cell markers.
D001932:Brain Neoplasms / Q000378:metabolism*; D002528:Cerebellar Neoplasms / Q000378:metabolism; D003388:Cranial Fossa, Posterior; D005353:Fibronectins / Q000378:metabolism*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006393:Hemangiopericytoma / Q000378:metabolism*; D006394:Hemangiosarcoma / Q000378:metabolism*; D006801:Humans; D007124:Immunoenzyme Techniques; D008526:Medulla Oblongata; D013120:Spinal Cord Neoplasms / Q000378:metabolism*
D005353:Fibronectins; D005904:Glial Fibrillary Acidic Protein