[Antibacterial activity of lamoxactam in combination with penicillin, ampicillin and amoxicillin against clinical strains of Enterococci, group B Streptococci and Listeria].
The antibacterial activity of moxalactam-penicillin combinations was studied against clinical isolates of Enterococci (20 strains), group B Streptococci (10), Listeria (3) and Enterobacteriaceae (10), using a microtiter checkerboard (FIC index, FBC index). Combinations of moxalactam (MX) with penicillin G, ampicillin or amoxicillin were usually synergistic against Enterococci and Listeria but with high MX concentrations. Against group B Streptococci, penicillin-MX combinations were synergistic (40%) or additive (60%) with MX concentrations easily achievable in the CSF.
D000658:Amoxicillin / Q000494:pharmacology; D000667:Ampicillin / Q000494:pharmacology; D004359:Drug Therapy, Combination; D004755:Enterobacteriaceae / Q000187:drug effects*; D006801:Humans; D008087:Listeria / Q000187:drug effects*; D009070:Moxalactam / Q000494:pharmacology*; D010400:Penicillin G / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology*; D013292:Streptococcus agalactiae / Q000187:drug effects*
D010406:Penicillins; D000667:Ampicillin; D000658:Amoxicillin; D010400:Penicillin G; D009070:Moxalactam
Activité antibactérienne du lamoxactam en association avec pénicilline, ampicilline et amoxicilline vis-à-vis de souches cliniques d'Entérocoques, de Streptocoques du groupe B et de Listeria.