Genome reorganization during cellular senescence.
It was previously suggested that aging of dividing cells depends on the reorganization of the cell genome during the division cycle and is determined by chance, intrinsic properties of the genome and environmental factors. A considerable amount of evidence has accumulated supporting the hypothesis. This is reviewed in terms of the reorganization taking place at the different orders of DNA structure.
D002455:Cell Division; D002470:Cell Survival / Q000528:radiation effects; D002875:Chromosomes / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D005796:Genes / Q000528:radiation effects; D006801:Humans; D013997:Time Factors
D004247:DNA