[A combination of methyldopa, hydrochlorothiazide and amiloride in the treatment of essential hypertension].
41 patients (35 males and 6 females) with moderate hypertension were treated with a combination of methyldopa/hydrochlorothiazide/amiloride (M/HCT/A). In a double blind study the blood-pressure-lowering effect of this combination was compared with the effect of M or HCT/A alone. After 8 weeks of treatment, the combination of M/HCT/A lowered the elevated blood pressure more efficiently than the two monotherapies . M counteracted the potassium-loosing effect of HCT/A, but did not prevent the elevation of serum urea, creatinine and uric acid which is observed under treatment with HCT/A.
D000328:Adult; D000368:Aged; D000584:Amiloride / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000097:blood; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008750:Methyldopa / Q000627:therapeutic use*; D008875:Middle Aged; D010919:Placebos; D011187:Posture; D011674:Pulse / Q000187:drug effects; D011719:Pyrazines / Q000627:therapeutic use*; D014508:Urea / Q000097:blood; D014527:Uric Acid / Q000097:blood
D004338:Drug Combinations; D010919:Placebos; D011719:Pyrazines; D006852:Hydrochlorothiazide; D014527:Uric Acid; D008750:Methyldopa; D000584:Amiloride; D014508:Urea; D003404:Creatinine
Eine Kombination von Methyldopa, Hydrochlorothiazid und Amilorid bei der Behandlung der essentiellen Hypertonie.