Immunoregulation of T-dependent responses by a cloned dendritic cell.
We have described a cloned dendritic cell, Clone Den-1, which is a potent accessory cell for some T-dependent immune responses. Clone Den-1 activates T cells in both autologous and allogeneic mixed lymphocyte reactions, but cannot present soluble antigen to T cells that co-recognize nominal antigen plus I-Ab gene products. In addition, Clone Den-1 or factors produced by it can reconstitute plaque-forming cell responses by accessory cell-depleted B plus T cells to the T-dependent antigen sheep red blood cells. The relationship of this clone to heterogeneous populations of dendritic cells and other accessory cells is discussed.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology; D002448:Cell Adhesion; D002460:Cell Line; D002999:Clone Cells / Q000276:immunology; D006462:Hemolytic Plaque Technique; D008211:Lymphocyte Cooperation; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010641:Phenotype; D012756:Sheep; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology*
D000954:Antigens, Surface