title: Thermodynamics of hapten-antibody interactions.
abstract: Two schools of thought are currently prevalent regarding the thermodynamic mechanism(s) of hapten-antibody interaction(s). While one school is a proponent of the hapten-antibody reaction being driven predominantly by enthalpy, the second school rationalizes the mechanism as an enthalpy-entropy compensation, the magnitude of the latter being dependent on the temperature at which hapten-antibody interaction is carried out.
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D000937:Antigen-Antibody Reactions; D001391:Azo Compounds; D001666:Binding Sites, Antibody; D002417:Cattle; D006168:Guinea Pigs; D006241:Haptens / Q000032:analysis / Q000276:immunology*; D008954:Models, Biological; D009282:Naphthalenesulfonates / Q000032:analysis / Q000276:immunology; D011487:Protein Conformation; D011817:Rabbits; D013696:Temperature; D013816:Thermodynamics
chemical_list: D000906:Antibodies; D001391:Azo Compounds; D006241:Haptens; D009282:Naphthalenesulfonates; C013617:nitrazine yellow