title: Preservation of anal function after total excision of the anal mucosa for Bowen's disease.
abstract: Six women with Bowen's disease of the anogenital area were treated by total excision of the anal mucosa, perianal skin and, in some cases, partial vulvectomy. Two patients had foci of microinvasive squamous carcinoma. Adequate tumor margins were determined by frozen sections. The resulting mucosal and cutaneous defects were grafted with medium split-thickness skin grafts applied to the anal canal and sutured circumferentially to the rectal mucosa. Grafts were held in place by a finger cot inserted in the anal canal and stuffed with cotton balls. Patients were constipated five or six days with codeine. The skin grafts healed per primam. One additional patient was similarly treated for a chronic herpetic ulceration of the anus and healed. Contrary to dire predictions, all patients were able to distinguish between gaseous and solid rectal contents and sphincter function was preserved. In one patient, Bowen's disease has recurred in the grafted perianal skin.
mesh_terms: D000328:Adult; D001003:Anal Canal / Q000503:physiopathology / Q000601:surgery*; D001913:Bowen's Disease / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D002278:Carcinoma in Situ / Q000601:surgery*; D002294:Carcinoma, Squamous Cell / Q000601:surgery*; D062109:Dermatologic Surgical Procedures; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000601:surgery*; D009378:Neoplasms, Multiple Primary / Q000601:surgery*; D012878:Skin Neoplasms / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D016038:Skin Transplantation; D014844:Vulva / Q000601:surgery; D014846:Vulvar Neoplasms / Q000601:surgery*