title: Comparison of quinidine by fluorescence polarization immunoassay and high pressure liquid chromatography.
abstract: Analysis of quinidine was performed using fluorescence polarization immunoassay (Abbott TDXTM) with an ion-pairing adsorption high pressure liquid chromatography (HPLC) technique as the comparative method. Correlation of 110 clinical samples was excellent (r2 = 0.983). TDX calibration appeared stable for 14 days. There is minimal contribution to the concentration of quinidine due to the presence of metabolite. The TDX method is rapid, precise, and accurate.
mesh_terms: D000918:Antibody Specificity; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003429:Cross Reactions; D005455:Fluorescent Antibody Technique; D006801:Humans; D011802:Quinidine / Q000097:blood*
chemical_list: D011802:Quinidine