[Comparative study of the effects of carminomycin 13-cyclohexylidenehydrazone and carminomycin on several immunologic responses of the body].
The effect of carminomycin and 13-cyclohexylidenhydrazone of carminomycin (13-CHC) on some immunological reactions was studied comparatively on mice. It was shown that 13-CHC administered intravenously or orally had an immunodepressive effect on the synthesis of the antibodies to the sheep red blood cells. By the character of the immunodepressive effect on the humoral and transplantation immunity 13-CHC was close to carminomycin. It had an inhibitory effect on the transplantation immunity, prevented the mice from death in the "graft-versus-host" system and increased the life-span of the cutaneous flaps.
D000818:Animals; D002360:Carubicin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D003630:Daunorubicin / Q000031:analogs & derivatives*; D006084:Graft Rejection / Q000187:drug effects; D006087:Graft vs Host Reaction / Q000187:drug effects; D006388:Hemagglutinins / Q000096:biosynthesis*; D007166:Immunosuppressive Agents; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D016038:Skin Transplantation; D014181:Transplantation Immunology / Q000187:drug effects*
D006388:Hemagglutinins; D007166:Immunosuppressive Agents; C041780:carminomycin 13-cyclohexylidenehydrazone; D002360:Carubicin; D003630:Daunorubicin
Sravnitel'noe izuchenie vliianiia 13-tsiklogeksilidengidrazona karminomitsina i karminomitsina na nekotorye immunologicheskie reaktsii organizma.