Acetaminophen-induced alterations in blood glucose and blood insulin levels in mice.
Three hours following administration of a toxic dose of the analgesic acetaminophen (500 mg/kg) to mice, blood glucose levels increased to 225 per cent. By six hours blood glucose levels decreased to approximately control values and by 24 hours glucose levels were 45 percent saline-treated control values. Immunoprecipitable blood insulin levels increased dramatically following acetaminophen treatment and were 300 per cent at 3 hours, 1100 per cent at 8 hours and 800 per cent at 24 hours. Saline treatment did not appreciably alter blood insulin levels. These observations indicate that acetaminophen may selectively alter pancreatic beta cells.
D000082:Acetaminophen / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D007328:Insulin / Q000097:blood*; D007515:Islets of Langerhans / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D000082:Acetaminophen