title: Prevalence of antibodies to Chlamydia trachomatis in Japanese persons determined by microimmunofluorescence using reticulate bodies as single antigen.
abstract: The incidence of humoral antibodies to Chlamydia trachomatis was determined in 1005 Japanese individuals of various ages. Formalin-fixed purified reticulate bodies of C. trachomatis (L2(434) strain) were used as antigens in the microimmunofluorescence test. Of 137 pregnant women, 25 (18.2%) had antibody titers of 1:10 or larger. Of 120 cord blood specimens from newborns, 16 (13.3%) were positive. Among 565 infants and children a progressive, age-related increase in seropositivity was observed except in 6- to 8-year-olds: 9.2% for infants under 1 year old; 20.8 to 25.0% for 1-to 5-year-olds; 11.7 to 17.6% for 6- to 8-year-olds; and 26.1 to 32.3% for 9- to 15-year-olds. Among 183 adults the seropositivity rate was between 20.0 and 26.7%, and a progressive increase in seropositivity was not clearly observed. These data suggest that C. trachomatis infection occurs commonly in Japanese adults and children.
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging; D000907:Antibodies, Bacterial / Q000032:analysis*; D000942:Antigens, Bacterial / Q000276:immunology; D044466:Asian People; D002648:Child; D002675:Child, Preschool; D002692:Chlamydia trachomatis / Q000276:immunology*; D005260:Female; D005312:Fetal Blood / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007564:Japan; D011247:Pregnancy
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial