title: The thickness of the glomerular basement membrane in irradiated and unirradiated Wistar rats and C-57 BL mice of different age groups.
abstract: In both Wistar rats and C-57 BL mice, the thickness of the glomerular basement membrane increases progressively with age. This change, which can be measured in cohorts of manageable size, produces a measurement of biological age--if one accepts the assumption that it correlates with the viability of the organism that exhibit it. Whole-body exposure to x-rays has no observable influence on this age-related change.
mesh_terms: D000375:Aging; D000818:Animals; D001485:Basement Membrane / Q000502:physiology / Q000528:radiation effects / Q000648:ultrastructure; D007678:Kidney Glomerulus / Q000502:physiology* / Q000528:radiation effects / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D011919:Rats, Inbred Strains; D014916:Whole-Body Irradiation / Q000009:adverse effects