title: Aldehydic peptides inhibiting renin.
abstract: Aldehydic peptides in which the C terminal residue is leucinal or phenylalaninal were synthesized. These compounds exhibited potent inhibition of renin activity and appeared to be precursors of transition state analogues for renin-catalysed amide bond hydrolysis.
mesh_terms: D000447:Aldehydes / Q000494:pharmacology*; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D000092502:Renin Inhibitors
chemical_list: D000447:Aldehydes; D009842:Oligopeptides; D000092502:Renin Inhibitors