title: Inhibition of glucose-induced insulin secretion by indomethacin and sodium salicylate in the fetal lamb.
abstract: The modulation of fetal insulin secretion by prostaglandins was studied with the aid of the prostaglandin synthesis inhibitors indomethacin and sodium salicylate in 10 chronically catheterized fetal lambs. Glucose-induced fetal insulin secretion was inhibited within 60 minutes by preinjection of either indomethacin or sodium salicylate in the fetal lambs. In the sodium salicylate experiments a significant (p less than 0.01) dose-related response (degree of insulin suppression) was noted between doses of 100 to 350 mg/kg of fetal weight. In a selected group of sodium salicylate injections prostaglandin levels were found to fall to 58% of control by 2 hours after injection. Five neonatal lambs exposed to a similar regimen were noted to have an exaggerated insulin response to glucose infusion when compared to fetal lambs. However, indomethacin or sodium salicylate pretreatment resulted in no suppression of glucose-induced insulin release. This finding may be of importance in explaining the observation of an increased incidence of fetal growth retardation after long-term exposure to salicylates in humans and in animal models.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005333:Fetus / Q000502:physiology*; D005947:Glucose / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology*; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D011247:Pregnancy; D011458:Prostaglandins E / Q000097:blood; D012459:Salicylates / Q000097:blood; D012756:Sheep; D012980:Sodium Salicylate / Q000494:pharmacology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D011458:Prostaglandins E; D012459:Salicylates; D005947:Glucose; D012980:Sodium Salicylate; D007213:Indomethacin