Long-term survival after bone marrow transplantation: a 15-year follow-up report of a patient with Wiskott-Aldrich syndrome.
In 1968 a 2-year-old boy with Wiskott-Aldrich syndrome was extremely ill with eczema, a series of life-threatening infections, and repeated hemorrhages into his skin, lungs, brain, and other internal organs. He was given high-dose cyclophosphamide therapy for immunosuppression, followed by bone marrow cells from his histocompatible, healthy sister. In the 15 years since bone marrow transplantation, he has had full T cell, partial B cell, and no hematopoietic engraftment. He has weathered the usual infectious diseases of childhood, has had no serious infections, and despite persistent thrombocytopenia has not had serious bleeding episodes.
D001402:B-Lymphocytes; D001792:Blood Platelets / Q000648:ultrastructure; D001853:Bone Marrow / Q000276:immunology; D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007165:Immunosuppression Therapy; D007621:Karyotyping; D007958:Leukocyte Count; D008285:Major Histocompatibility Complex; D008297:Male; D010976:Platelet Count; D013601:T-Lymphocytes; D014923:Wiskott-Aldrich Syndrome / Q000276:immunology / Q000628:therapy*
D007136:Immunoglobulins