Aqueous humor cytology of pseudophakic bullous keratopathy.
The long-term effects of the interaction between an IOL and the immune system of the implanted patient are not yet clear. This study presents the results of aqueous humor (AH) cytological analysis of 51 patients undergoing intraocular surgery for cataract, and aphakic (ABK) or pseudophakic bullous keratopathy (PBK). Cataract AH was acellular (N = 8). The mean ABK AH cell count was 8.5 +/- 6.4 cells per high power field (hpf) of cytologically filtered specimens; mean PBK cell count was 30.2 +/- 13.0. If inflamed eyes are defined as those with more than one cell/hpf, a statistically significant greater number of PBK eyes than ABK eyes were inflamed (93% versus 44%, P less than 0.003 chi square). More than 99% of the nucleated cells were mononuclear histiocytes. One PBK patient had many multinucleated giant cells in the AH.
D001036:Aphakia, Postcataract / Q000473:pathology; D001082:Aqueous Humor / Q000473:pathology*; D002387:Cataract Extraction; D003316:Corneal Diseases / Q000473:pathology*; D005549:Foreign-Body Reaction / Q000473:pathology; D006801:Humans; D007910:Lenses, Intraocular / Q000009:adverse effects; D014605:Uveitis / Q000209:etiology