title: Antioxidant-stabilized amphotericin B.
abstract: A review of several recent reports shows that many compounds possessing antioxidant or mild reducing properties can enhance the bioactivity of amphotericin B. Antioxidants apparently retard autoxidative inactivation of this primary antifungal antibiotic. Stabilization of amphotericin B in this manner might have practical applications. Some important possibilities are identified and discussed.
mesh_terms: D000666:Amphotericin B / Q000378:metabolism*; D000975:Antioxidants / Q000494:pharmacology*; D004355:Drug Stability; D010084:Oxidation-Reduction
chemical_list: D000975:Antioxidants; D000666:Amphotericin B