Diurnal GIP, PP and insulin levels in morbid obesity before and after stapled gastric partitioning with gastro-gastrostomy.
The diurnal gastric inhibitory polypeptide (GIP), pancreatic polypeptide (PP) and insulin levels in eight morbidly obese subjects were studied before and four weeks and five months after a stapled gastric partitioning. The integrated release of all three peptides was significantly reduced postoperatively, although the profiles of the plasma GIP and PP curves were similar. On the other hand, the diurnal insulin pattern was changed from a pathological prolonged hyperinsulinemia starting shortly after breakfast and lasting till late in the evening, to a normal pattern with small, shortlived postprandial peaks.
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002940:Circadian Rhythm; D005260:Female; D005749:Gastric Inhibitory Polypeptide / Q000097:blood*; D005768:Gastrointestinal Hormones / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000097:blood* / Q000628:therapy; D010191:Pancreatic Polypeptide / Q000097:blood*; D013270:Stomach / Q000601:surgery*
D001786:Blood Glucose; D005768:Gastrointestinal Hormones; D007328:Insulin; D005749:Gastric Inhibitory Polypeptide; D010191:Pancreatic Polypeptide