title: Extracellular virulence factors of fish Vibrio: relationships between toxic material, hemolysin, and proteolytic enzyme.
abstract: Biological activities of cell-free culture filtrate of 3 virulent strains of fish Vibrio were examined to determine the relationship to the pathogenesis of fish vibriosis. Among the 3 strains examined, V anguillarum strains NCMB6 and NCMB571 produced hemolysin and protease, whereas V ordalii strain N7802 did not. Culture filtrate of strain NCMB571 were lethal to rainbow trout and produced a cytotoxic effect on fish cell line. Results revealed that the extracellular products may be involved in the pathogenesis of fish vibriosis.
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000096:biosynthesis* / Q000633:toxicity; D002460:Cell Line; D004912:Erythrocytes / Q000276:immunology; D005393:Fish Diseases / Q000209:etiology*; D006054:Goldfish; D006460:Hemolysin Proteins / Q000096:biosynthesis*; D006461:Hemolysis; D010447:Peptide Hydrolases / Q000096:biosynthesis*; D012474:Salmon; D012487:Salmonidae; D014337:Trout; D014733:Vibrio / Q000378:metabolism / Q000472:pathogenicity*; D014735:Vibrio Infections / Q000209:etiology / Q000662:veterinary*; D014774:Virulence
chemical_list: D001427:Bacterial Toxins; D006460:Hemolysin Proteins; D010447:Peptide Hydrolases