[Effect of the inhibition of prostaglandin biosynthesis on the hematopoietic status of irradiated mice].
The administration to mice of preparations inhibiting prostaglandin synthesis was shown to reduce the post-irradiation cytopenia in the peripheral blood and to increase the total cellularity of the bone marrow and the yield of splenic endocolonies. When the exposed mice were injected with intact myelocaryocytes, at the background of the inhibited prostaglandin biosynthesis, the number of exogenous colonies increased.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D016026:Bone Marrow Transplantation; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects; D007962:Leukocytes / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011833:Radiation Injuries, Experimental / Q000209:etiology; D013997:Time Factors
D011448:Prostaglandin Antagonists
Vliianie ingibirovaniia biosinteza prostaglandinov na sostoianie gemopoéza obluchennykh mysheĭ.