The proteolytic activity of human prostate-specific antigen.
Human prostate-specific antigen has been found to exhibit a mild activity of protease at neutral pH. This finding is based on two observations: a proteolytic activity was always associated with the antigen fractions during purification, and the proteolytic activity and the antigen were precipitated with specific antibody to the antigen. In comparison with physico-chemical and catalytic properties of known proteases, human prostate-specific antigen is a distinct neutral protease.
D000595:Amino Acid Sequence; D000818:Animals; D000941:Antigens / Q000378:metabolism*; D002417:Cattle; D006041:Goats; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D051379:Mice; D010447:Peptide Hydrolases / Q000378:metabolism*; D011467:Prostate / Q000276:immunology* / Q000378:metabolism; D013379:Substrate Specificity; D013552:Swine
D000941:Antigens; D010447:Peptide Hydrolases