[Treatment of intestinal atony following gynecologic operations. Study on the effectiveness and tolerance of ceruletide].
The efficacy and tolerability of Ceruletide and Neostigmin were compared in patients with postoperative intestinal atonia after extensive gynecological surgical operations. Patients treated with Ceruletide (n = 30, dosage of Ceruletide 2 ng/kg/min. i.v.) showed earlier defecation than the Neostigmin-group (n = 30, dosage of neostigmin 3 x 0,5 mg/die). The frequency of side effects was comparable in both groups, patients treated with Ceruletide suffered mainly from gastrointestinal symptoms (nausea) whereas patients treated with Neostigmin complained of disorders of circulation. Ceruletide is faster effective than Neostigmin, the tolerability of both drugs is equivalent.
D001794:Blood Pressure / Q000187:drug effects; D002108:Ceruletide / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D003248:Constipation / Q000188:drug therapy*; D003672:Defecation / Q000187:drug effects; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D005831:Genital Diseases, Female / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D009388:Neostigmine / Q000627:therapeutic use; D011183:Postoperative Complications / Q000188:drug therapy
D009388:Neostigmine; D002108:Ceruletide
Behandlung der Darmatonie nach gynäkologischen Operationen. Studie zur Wirksamkeit und Verträglichkeit von Ceruletid.