Recurrent idiopathic fetal hydrops: results of prenatal therapy.
A case of nonimmune hydrops recurring within a sibship is reported. Progressive severe fetal ascites and hydramnios at 31 weeks' gestation led to fetal paracentesis for both therapeutic and diagnostic purposes. A successfully placed indwelling peritoneal-amniotic diversion shunt functioned well but became dislodged, and rapid recurrence of ascites and hydramnios required two subsequent drainage procedures. Neonatal death occurred from pulmonary failure after delivery at 34 weeks' gestation, as had happened in the similarly affected sibling. Amniotic and fetal peritoneal pressures, biochemical analysis, and bacteriologic studies of fluid samples are reviewed. Although this experience adds to the knowledge of fluid dynamics in fetal ascites and hydramnios, it does not clearly support or refute such therapy in the care of fetal hydrops from nonimmunologic causes. Management issues are discussed.
D000328:Adult; D000653:Amniotic Fluid / Q000032:analysis; D001202:Ascitic Fluid / Q000276:immunology / Q000382:microbiology; D002585:Cesarean Section; D004322:Drainage / Q000295:instrumentation / Q000379:methods; D004487:Edema / Q000209:etiology / Q000601:surgery*; D005260:Female; D005315:Fetal Diseases / Q000209:etiology / Q000601:surgery*; D006801:Humans; D007231:Infant, Newborn; D006831:Polyhydramnios / Q000628:therapy*; D011247:Pregnancy; D012008:Recurrence; D012131:Respiratory Insufficiency / Q000209:etiology; D012306:Risk