Anti-hypoxic effect of piracetam and its interaction with prostacyclin.
The anti-hypoxic effect of piracetam was studied using the following experimental methods: hypobaric and anoxic hypoxia in mice, complete ischemia by decapitation in mice, incomplete ischemia by bilateral carotid occlusion in rats and hemic hypoxia in rats. Cinnarizine and vinpocetine were used as reference drugs. In hypobaric hypoxia, anoxic hypoxia, and complete ischemia by decapitation the interaction of piracetam with the effect of prostacyclin (PGI2) was investigated. Piracetam showed anti-hypoxic effect in all the methods used. Its effect was greater than that of cinnarizine and similar to that of vinpocetine. Piracetam potentiated the effect of PGI2 shifting the anti-hypoxic dose-response curve of PGI2 to the left.
D000818:Animals; D001274:Atmospheric Pressure; D002936:Cinnarizine / Q000627:therapeutic use; D004357:Drug Synergism; D011464:Epoprostenol / Q000627:therapeutic use*; D005260:Female; D000860:Hypoxia / Q000188:drug therapy*; D007511:Ischemia / Q000188:drug therapy; D051379:Mice; D008815:Mice, Inbred Strains; D010889:Piracetam / Q000627:therapeutic use*; D011760:Pyrrolidinones / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D014748:Vinca Alkaloids / Q000627:therapeutic use
D011760:Pyrrolidinones; D014748:Vinca Alkaloids; D002936:Cinnarizine; C013983:vinpocetine; D011464:Epoprostenol; D010889:Piracetam