[Biological effectiveness of ionizing radiations of various quality in Escherichia coli bacteria (a theoretical analysis). A cell inactivation model].
The dependence of the radiosensitivity of bacteria (the wild type, superresistant and rec-mutants) on linear energy transfer (LET) is considered. A nonformal model of inactivation of different bacterial mutants has been developed on the basis of the experimental data available. The concept of "metastable siles" (MS) is introduced. MS are peculliar DNA lesions arising from the occurrence of large nucleolytic gaps on both strands of DNA. Different mechanisms responsible for MS formation are considered. The kinetic equations of the model are solved and the parameters determined for both sensitive and resistant mutants.
D004260:DNA Repair / Q000528:radiation effects; D004269:DNA, Bacterial / Q000528:radiation effects; D004735:Energy Transfer / Q000528:radiation effects; D004926:Escherichia coli / Q000528:radiation effects*; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D009154:Mutation; D011836:Radiation Tolerance; D012062:Relative Biological Effectiveness
D004269:DNA, Bacterial
Biologicheskaia éffektivnost' ioniziruiushchikh izlucheniĭ raznogo kachestva u bakteriĭ Escherichia coli (teoreticheskiĭ analiz). Model' inaktivatsii kletok.