Effect of bacterial endotoxin on body temperature, plasma zinc and plasma concentrations of the acute-phase protein serum amyloid p component in mice.
Bacterial endotoxin and lipid A evoked dose-dependent increases in body temperature and plasma SAP concentrations and dose-dependent falls in plasma zinc concentrations in mice. The respective sensitivities of the three variables to lipid A or to whole endotoxin had the relation SAP greater than Zinc much greater than body temperature; zinc and SAP responses were evoked by less than 1 ng lipid A/endotoxin. Pretreatment with indomethacin prevented only the temperature response to lipid A. Pretreatment with dexamethasone did not affect the temperature response but diminished the zinc response and enhanced the SAP response to lipid A.
D000682:Amyloid / Q000097:blood*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D003907:Dexamethasone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D007213:Indomethacin / Q000494:pharmacology; D008050:Lipid A / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012475:Salmonella; D000683:Serum Amyloid P-Component; D012762:Shigella dysenteriae; D015032:Zinc / Q000097:blood*
D000682:Amyloid; D004731:Endotoxins; D008050:Lipid A; D000683:Serum Amyloid P-Component; D003907:Dexamethasone; D015032:Zinc; D007213:Indomethacin