The application of a microcomputer for enzyme immunoassay (Emit) determination of serum quinidine concentrations.
Quinidine is a commonly used drug for the treatment of cardiac arrhythmias. Avoidance of toxicity and monitoring of therapy can be readily accomplished by determining serum concentrations of quinidine by enzyme immunoassay (Emit) using a centrifugal analyzer and reducing the data with a desk-top microcomputer. For therapeutic and toxic drug ranges maximum within-run CV was under 6.0%, while between-run CV was under 10.0% in the therapeutic range and under 15.0% in the toxic range.
D006801:Humans; D007124:Immunoenzyme Techniques; D008838:Microcomputers; D008991:Monitoring, Physiologic / Q000379:methods; D011802:Quinidine / Q000097:blood* / Q000627:therapeutic use
D011802:Quinidine