title: Immunohistochemical evidence for preproenkephalin A synthesis in human retinoblastoma.
abstract: Human retinoblastoma contains clusters of cells immunoreactive for methionine-enkephalin and methionine-enkephalin-arginine-phenylalanine. Some tumour cells also exhibited methionine-enkephalin-arginine-glycine-leucine-like immunoreactivity. The results are in agreement with those obtained with similar testing of neuroblastoma cell cultures. It is concluded that some human retinoblastoma cells are capable of synthesizing preproenkephalin A or parts of this molecule.
mesh_terms: D002478:Cells, Cultured; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives / Q000276:immunology; D004745:Enkephalins / Q000096:biosynthesis*; D005134:Eye Neoplasms / Q000276:immunology / Q000378:metabolism*; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007223:Infant; D008856:Microscopy, Fluorescence; D011498:Protein Precursors / Q000096:biosynthesis*; D012175:Retinoblastoma / Q000276:immunology / Q000378:metabolism*
chemical_list: D004745:Enkephalins; D011498:Protein Precursors; D004744:Enkephalin, Methionine; C027511:enkephalin-Met, Arg(6)-Phe(7)-; C033453:enkephalin-Met, Arg(6)-Gly(7)-Leu(8)-; C033660:preproenkephalin