[Does the hematopoietic stem cell exist?].
The hypothesis concerning the existence of a self-maintaining, i. e. "immortal" hemopoietic stem cell has no conclusive evidence. The data demonstrating the existence of hemopoietic cells with very high proliferative potentials, which are formed only during embryogenesis are discussed. Clonal expansion of these cells can support hemopoiesis during the entire life of the adult organism.
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002470:Cell Survival; D002478:Cells, Cultured; D002999:Clone Cells / Q000166:cytology / Q000201:enzymology; D003114:Colony-Forming Units Assay; D004303:Dosage Compensation, Genetic; D005260:Female; D005819:Genetic Markers; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000201:enzymology; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D051379:Mice; D008954:Models, Biological; D011770:Pyruvate Kinase / Q000235:genetics; D013154:Spleen / Q000166:cytology
D005819:Genetic Markers; D007527:Isoenzymes; D005954:Glucosephosphate Dehydrogenase; D011770:Pyruvate Kinase
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