[The role of vitamin K in the metabolism of connective tissue biopolymers (review)].
Metabolism of connective tissue biopolymers was studied under conditions of various content of vitamin K in the body. The data obtained suggest the existence of a new metabolic effect of vitamin K--its participation as an allosteric activator in regulation of glucosamine synthetase (EC 5.3.1.19). The anabolic effect of vitamin K on connective tissue is apparently related to an increase in the rate of biosynthesis of glucosamine-6-phosphate--general precursor of glycosaminoglycans, glycoproteins and hexosamine-containing glycolipids.
D000818:Animals; D001704:Biopolymers; D003094:Collagen / Q000378:metabolism; D003238:Connective Tissue / Q000378:metabolism*; D004549:Elastin / Q000378:metabolism; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism; D006595:Hexosamines / Q000378:metabolism; D010539:Permeability; D051381:Rats; D014812:Vitamin K / Q000378:metabolism*; D014813:Vitamin K Deficiency / Q000378:metabolism
D001704:Biopolymers; D006025:Glycosaminoglycans; D006595:Hexosamines; D014812:Vitamin K; D003094:Collagen; D004549:Elastin; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing)
Rol' vitamina K v obmene biopolimerov soedinitel'noĭ tkani (obzor).