title: Reversal of pyrithiamine-induced growth inhibition of Saccharomyces cerevisiae by oxythiamine.
abstract: Oxythiamine reversed the growth inhibition of Saccharomyces cerevisiae caused by pyrithiamine, although oxythiamine alone inhibited yeast cell growth. This phenomenon was explained by thiamine production from these 2 thiamine antagonists which was demonstrated using cell suspensions and the crude extract of S. cerevisiae.
mesh_terms: D010119:Oxythiamine / Q000494:pharmacology*; D011726:Pyridinium Compounds / Q000494:pharmacology*; D011745:Pyrithiamine / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000254:growth & development*; D013831:Thiamine / Q000096:biosynthesis; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D011726:Pyridinium Compounds; D013844:Thiazoles; D010119:Oxythiamine; D011745:Pyrithiamine; D013831:Thiamine