[Therapeutic efficacy of KS-R1, an ampicillin suppository, against experimental infections in mice].
In experimental infections induced with S. aureus, S. pneumoniae, E. coli, K. pneumoniae, P. mirabilis and H. influenzae in mice, the therapeutic efficacies of ampicillin (ABPC) after its rectal administration were compared with those obtained after its oral and subcutaneous administration, and the following results were obtained. Generally, in experimental intraperitoneal infections of mice, the effects of ABPC after rectal administration were inferior to those after subcutaneous administration and superior to those after oral administration. In experimentally induced intraperitoneal and urinary tract infection of E. coli KC-14, similar results were obtained. The plasma levels were reflected as the difference between various administration in the therapeutic efficacies observed with ABPC.
D000284:Administration, Oral; D000667:Ampicillin / Q000008:administration & dosage* / Q000097:blood; D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D004927:Escherichia coli Infections / Q000188:drug therapy; D005260:Female; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D010538:Peritonitis / Q000188:drug therapy; D013488:Suppositories; D014552:Urinary Tract Infections / Q000188:drug therapy
D013488:Suppositories; D000667:Ampicillin