Differential response of plasma glucose, amino acids and nonesterified fatty acids to insulin in depressed patients.
Levels of plasma glucose, nonesterified fatty acids and total amino acids at various times after insulin administration were determined in patients with either major depressive disorder or dysthymic disorder and in normal control subjects. For the first 30 min following insulin administration, the rate of change in glucose levels was significantly less among the patients with major depressive disorder than among either the patients with dysthymic disorder or the normal control subjects. However, during the same time period, the rates of decline in nonesterified fatty acids and total amino acids were indistinguishable among the three subject groups. Therefore, the insulin resistance in terms of glucose levels that is observed in patients with major depressive disorder is not generalized to other substances affected by insulin.
D000328:Adult; D000596:Amino Acids / Q000097:blood*; D001714:Bipolar Disorder / Q000097:blood / Q000175:diagnosis; D001786:Blood Glucose / Q000378:metabolism*; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D006801:Humans; D007328:Insulin; D008297:Male; D008875:Middle Aged
D000596:Amino Acids; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin