Activation of macrophage complement receptors for phagocytosis.
Macrophage complement receptors, while innately incapable of promoting phagocytosis, can be activated to do so by a number of inflammatory stimuli and by several immunologic mechanisms. Studies with a complement receptor-activating lymphokine reveal that activation occurs as a result of mobilization of innately immobile receptors and suggest that receptor mobility is a prerequisite for phagocytosis. Since Fc receptors are susceptible to blockade by immune complexes at inflammatory sites, phagocytosis mediated by macrophage complement receptors may be of prime importance in vivo.
D000818:Animals; D006801:Humans; D007249:Inflammation / Q000276:immunology; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology*; D010587:Phagocytosis; D011951:Receptors, Complement / Q000276:immunology*; D011961:Receptors, Fc / Q000276:immunology
D011951:Receptors, Complement; D011961:Receptors, Fc