[Activity of the DNA repair enzyme uracil-DNA-glycosylase in mammalian species differing in longevity and the level of liver cell ploidy].
The activity of uracil-DNA glycosylase (UDG) was studied for livers of 13 mammalian species belonging to four orders. DNA contents were also measured in isolated hepatocytes. The enzymatic activity was shown to increase with the increase in the mean ploidy of liver parenchymal cells. The activity of UDG was 20 times as high when the mean liver cell ploidy of different mammalian species doubled. A reverse dependence between the UDG activity and species life spans is also revealed.
D000818:Animals; D003411:Arvicolinae; D002335:Carnivora; D002417:Cattle; D045647:DNA Glycosylases; D004260:DNA Repair; D005589:Foxes; D006168:Guinea Pigs; D006736:Horses; D008099:Liver / Q000201:enzymology / Q000648:ultrastructure*; D008136:Longevity; D051379:Mice; D008907:Mink; D009699:N-Glycosyl Hydrolases / Q000032:analysis*; D011123:Polyploidy; D051381:Rats; D013045:Species Specificity; D013552:Swine; D051981:Uracil-DNA Glycosidase
D045647:DNA Glycosylases; D009699:N-Glycosyl Hydrolases; D051981:Uracil-DNA Glycosidase
Atkivnost' fermenta reparatsii DNK uratsil-DNK-glikozilazy u vidov mlekopitaiushchikh, razlichaiushchikhsia po prodolzhitel'nosti zhizni i urovniu ploidnosti kletok pecheni.