Immune monitoring of pregnancy in renal transplanted patients.
Immune studies were performed in eight pregnancies occurring after renal transplantation (tx). In three cases a regular, long-term immune monitoring before, during, and after the pregnancy was possible. The results showed 1) no changes concerning OKT 3, 4, 8, and SMIg-defined T- and B-lymphocyte subsets in the mothers: 2) a higher level of spontaneous E- and normal E-rosette-defined T-subsets in the mothers rejecting their allografts; 3) a stronger response to mitogen and antigen stimulation and a stronger mixed lymphocyte culture (MLC) response towards the infants also in those rejecting their grafts; 4) the offspring of the transplanted mothers showed a weaker immune responder state compared with the offspring of six age-matched normal mothers.
D000911:Antibodies, Monoclonal / Q000276:immunology; D005260:Female; D006084:Graft Rejection; D006801:Humans; D016030:Kidney Transplantation; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D012397:Rosette Formation
D000911:Antibodies, Monoclonal