title: Transcriptional interference in avian retroviruses--implications for the promoter insertion model of leukaemogenesis.
abstract: The downstream (3') long terminal repeat (LTR) of an avian retroviral provirus is unable to act as an efficient promoter of transcription when a transcriptionally active upstream (5') LTR is present. This transcriptional interference may explain the observation that only deleted proviruses have been observed inserted adjacent to c-myc in avian leukosis virus induced lymphomas of chickens.
mesh_terms: D000818:Animals; D002472:Cell Transformation, Viral; D002645:Chickens; D005786:Gene Expression Regulation; D007328:Insulin / Q000235:genetics; D007942:Leukemia, Experimental / Q000235:genetics / Q000382:microbiology; D009154:Mutation; D009857:Oncogenes; D009876:Operon; D012091:Repetitive Sequences, Nucleic Acid; D012190:Retroviridae / Q000235:genetics*; D014158:Transcription, Genetic; D014759:Viral Envelope Proteins / Q000235:genetics
chemical_list: D007328:Insulin; D014759:Viral Envelope Proteins