Different prednisolone pharmacokinetics in Cushingoid and non-Cushingoid kidney transplant patients.
Prednisolone pharmacokinetics have been compared in 16 Cushingoid and 46 non-Cushingoid long term kidney transplant recipients. The Cushingoid patients had a significantly (p less than 0.05) higher peak concentration, a longer elimination half-time, a greater area under the time-concentration curve of total and free prednisolone, and a lower total body clearance of prednisolone. It is suggested that prednisolone pharmacodynamics may be influenced by pharmacokinetic differences, and that differences in renal function may be an important contributing factor.
D000328:Adult; D003480:Cushing Syndrome / Q000097:blood* / Q000209:etiology; D005260:Female; D006801:Humans; D016030:Kidney Transplantation; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000009:adverse effects / Q000097:blood*
D011239:Prednisolone