[Comparison of serum and prostatic levels of tobramycin].
In 19 patients with various prostatic diseases, serum and prostatic tissue levels of tobramycin were determined by bioassay and enzyme immunoassay after 1, 3 or 4 intramuscular injections of 75 mg tobramycin. The last injection was given ninety minutes prior to prostatectomy. Mean serum and prostatic tissue levels were respectively 3.55 micrograms/ml and 1.70 micrograms/g by bioassay, and 3.55 micrograms/ml and 2.37 micrograms/g by enzyme immunoassay. There was no significant difference in prostatic tissue levels between patients who received 3 or 4 drug doses and those who received one dose. Prostatic tissue levels were not significantly different in adenoma and chronic prostatitis.
D001681:Biological Assay; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D011467:Prostate / Q000378:metabolism*; D011469:Prostatic Diseases / Q000378:metabolism*; D014031:Tobramycin / Q000097:blood / Q000378:metabolism*
D014031:Tobramycin
Comparaison des taux sériques et prostatiques de la tobramycine.