Metabolic activation and deactivation of mutagens by preparations of human lung parenchyma and bronchial tree.
69 S12 preparations of human lung (43 of peripheral lung parenchyma and 26 bronchial preparations) were assayed for their ability to activate procarcinogens to mutagenic metabolites in the Ames test or to lower the mutagenic response of direct-acting compounds. No sample activated polycyclic aromatic hydrocarbons, such as 3-methylcholanthrene, benzo[a]pyrene or its metabolites 3-hydroxy-B(a)P and B(a)P-trans-7,8-diol, and only borderline effects were observed with cigarette-smoke condensates. Conversely, some activating ability was detected in the case of 2-aminofluorene and of cyclophosphamide. The same samples produced a slight decrease of mutagenicity of epichlorohydrin and ICR-191 and a more pronounced loss of activity of sodium dichromate and 4-nitroquinoline N-oxide.
D001711:Biotransformation; D001980:Bronchi / Q000378:metabolism*; D003520:Cyclophosphamide / Q000378:metabolism / Q000633:toxicity; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008861:Microsomes / Q000378:metabolism*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism* / Q000633:toxicity; D009154:Mutation; D012486:Salmonella typhimurium / Q000187:drug effects; D012906:Smoke; D013329:Structure-Activity Relationship
D009153:Mutagens; D012906:Smoke; D003520:Cyclophosphamide