UV irradiation alters deoxynucleoside triphosphate pools in Escherichia coli.
UV irradiation of exponentially growing Escherichia coli increased intracellular concentration of dATP and dTTP without significantly changing the concentrations of dGTP and dCTP. These selective increases in dATP and dTTP pools are seen in wild-type E. coli K12 and AB1157, as well as in recA and umuC strains, and are proportional to UV dose. The possible significance of these findings with respect to induction of the SOS response and nontargeted mutagenesis are discussed.
D003854:Deoxyribonucleotides / Q000378:metabolism / Q000528:radiation effects*; D004926:Escherichia coli / Q000254:growth & development / Q000378:metabolism / Q000528:radiation effects*; D007700:Kinetics; D014466:Ultraviolet Rays
D003854:Deoxyribonucleotides