The structural basis of PPHN.
Discussed in this article are the three main anatomic types of persistent pulmonary hypertension of the newborn; (1) maladaptation of the pulmonary vascular bed; (2) excessive muscularization of the pulmonary vascular bed; and (3) underdevelopment of the pulmonary vascular bed.
D000653:Amniotic Fluid; D000818:Animals; D001158:Arteries / Q000473:pathology; D003937:Diagnosis, Differential; D006330:Heart Defects, Congenital / Q000175:diagnosis / Q000473:pathology; D006345:Heart Septal Defects, Ventricular / Q000175:diagnosis / Q000473:pathology; D006548:Hernia, Diaphragmatic / Q000175:diagnosis / Q000473:pathology; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D006976:Hypertension, Pulmonary / Q000473:pathology; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities; D008168:Lung / Q000002:abnormalities / Q000098:blood supply / Q000473:pathology; D008470:Meconium; D010547:Persistent Fetal Circulation Syndrome / Q000175:diagnosis / Q000473:pathology* / Q000503:physiopathology; D011015:Pneumonia, Aspiration / Q000175:diagnosis / Q000209:etiology / Q000473:pathology; D011379:Prognosis; D011650:Pulmonary Alveoli / Q000098:blood supply / Q000473:pathology; D011652:Pulmonary Circulation; D011817:Rabbits; D051381:Rats; D012756:Sheep; D014655:Vascular Resistance; D014661:Vasoconstriction