Comparative study of the bronchospasmolytic effect of fenoterol (0.2 mg) salbutamol (0.4 mg) as powder inhalations in 20 patients with reversible bronchial obstruction.
In a double-blind crossover study, the effects of fenoterol powder inhaled from capsules (0.2 mg) and the powder inhaler with salbutamol capsules (0.4 mg) were compared. A single dose of each was administered on 2 subsequent days in random order. The effects on lung function test results were followed from 15 to 360 min after administration. Apart from the overall comparison, special attention was paid to the beginning and the end of the test periods. Statistically significant differences were found only in a few parameters and showed a trend for fenoterol to have a somewhat longer effect and for salbutamol to have a faster onset of effect. The differences between the effects of the two drugs were clinically not relevant. Blood pressure and heart rate were unaffected by either treatment.
D000281:Administration, Intranasal; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects*; D000420:Albuterol / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D005280:Fenoterol / Q000627:therapeutic use*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D011208:Powders
D004983:Ethanolamines; D011208:Powders; D005280:Fenoterol; D000420:Albuterol