[Study of morphological types of nephrotic glomerulonephritis and the number of glucocorticoid receptors of lymphocytes for prognosis of the effectiveness of glucocorticoid therapy].
The study of the glucocortocoid receptors (GCR) level of blood lymphocytes in 31 patients with glomerulonephritis (GN) of the nephrotic type revealed the lack of a clear parallelism between the morphological type of GN and GCR level. A relatively low GCR level correlates with the resistance of nephrotic GN patients regardless of the GN morphological type. The patients with a relatively low GCR level did not respond to the glucocorticoid (GC) therapy even if they had morphological types of nephrotic GN considered to be "favourable" for this therapy (mesangio-proliferative and membranous GN). It is stated that the GC therapy for such patients is not justified.
D000293:Adolescent; D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D005921:Glomerulonephritis / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D007668:Kidney / Q000473:pathology*; D008214:Lymphocytes / Q000032:analysis*; D008297:Male; D009404:Nephrotic Syndrome / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D011239:Prednisolone / Q000627:therapeutic use*; D011379:Prognosis; D011965:Receptors, Glucocorticoid / Q000302:isolation & purification*; D011987:Receptors, Steroid / Q000302:isolation & purification*
D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D011239:Prednisolone
Izuchenie morfologicheskikh tipov nefroticheskogo glomerulonefrita i kolichestva gliukokortikoidnykh retseptorov limfotsitov krovi dlia prognozirovaniia effektivnosti gliukokortikoidnoĭ terapii.