Protective effect of low doses in mutagenesis with ethylene oxide in E. coli.
The influence of pre-exposure to low doses of ethylene oxide (EtO) on the frequency of leu+ revertants in the E. coli strain, WU36-10, and its excision-repair-deficient mutant, WU36-10-89, after treatment with high doses of EtO, was studied. Low doses had an adaptive effect in both strains with respect to high doses of EtO which was manifested by a decreased number of revertants and lower lethality.
D004260:DNA Repair / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004926:Escherichia coli / Q000235:genetics; D005027:Ethylene Oxide / Q000494:pharmacology*; D009154:Mutation / Q000187:drug effects*
D005027:Ethylene Oxide