title: Correlation of DNA adenine methylase activity with spontaneous mutability in Escherichia coli K-12.
abstract: Using a multicopy plasmid in which the tac promoter has been placed in front of the dam gene of Escherichia coli K-12, we show that levels of DNA adenine methylase activity are correlated with the spontaneous mutation frequency.
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics* / Q000502:physiology; D004260:DNA Repair; D004269:DNA, Bacterial / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics*; D008780:Methyltransferases / Q000235:genetics* / Q000502:physiology; D009154:Mutation; D010957:Plasmids; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific)
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial; D008780:Methyltransferases; D015265:Site-Specific DNA-Methyltransferase (Adenine-Specific)