Stimulation of human peripheral lymphocytes with endotoxin and radiodetoxified endotoxin.
The effects of parent endotoxin and radiodetoxified endotoxin on human peripheral lymphocytes were compared in experiments in vitro. Radiodetoxified endotoxin is able to exceed the degree of the stimulation induced by parent endotoxin and its stimulatory effect. At the same time, no change was observed in the presence of autologous serum. Radiodetoxified endotoxin did not inhibit the phytohaemagglutinin-induced proliferative response.
D002478:Cells, Cultured; D004731:Endotoxins / Q000494:pharmacology* / Q000528:radiation effects; D004926:Escherichia coli / Q000528:radiation effects; D005720:Gamma Rays; D006801:Humans; D007700:Kinetics; D008070:Lipopolysaccharides / Q000494:pharmacology* / Q000528:radiation effects; D008213:Lymphocyte Activation / Q000187:drug effects*; D010835:Phytohemagglutinins / Q000494:pharmacology
D004731:Endotoxins; D008070:Lipopolysaccharides; D010835:Phytohemagglutinins