A new suppressor of mutations in the DNA repair-recombination genes of bacteriophage T4: sur.
A new mutation designated sur was isolated as a suppressor of a mutation in the uvsX gene of T4 phage. Unlike the other suppressors of mutations in genes involved in DNA repair and recombination, sur has a wide range, suppressing both DNA repair and replication defects in mutations in genes uvsX, uvsY, 46, 47, and 59. However, its suppressor functions may be confined to the uvsX-uvsY DNA repair pathway since sur did not suppress a mutation in the denV gene. The sur mutation results in an increased degradation of host DNA to an acid-soluble form, but this increase was blocked by a mutation in gene 46 (nuclease) indicating that the sur function is involved in an earlier step in the degradation of host DNA. This increased degradation of host DNA might be a reflection of a compensatory increase in an alternate DNA repair activity in the [sur] mutant.
D003433:Crosses, Genetic; D004260:DNA Repair; D004261:DNA Replication; D004926:Escherichia coli / Q000235:genetics* / Q000528:radiation effects; D005798:Genes, Bacterial; D005799:Genes, Dominant; D005814:Genes, Viral; D007700:Kinetics; D009154:Mutation; D011995:Recombination, Genetic; D013489:Suppression, Genetic; D013604:T-Phages / Q000235:genetics* / Q000528:radiation effects; D014466:Ultraviolet Rays