Uptake and utilization of deoxynucleoside 5'-monophosphates by Mycoplasma mycoides subsp. mycoides.
Mycoplasma mycoides subsp. mycoides has been shown to possess an unusual capacity for the uptake and utilization of exogenous deoxyribonucleoside 5'-monophosphates intact without prior dephosphorylation. In this study, it was found that once inside the cell, deoxyribonucleoside 5'-monophosphates were rapidly phosphorylated to the triphosphate level and incorporated into DNA. Catabolism of deoxyribonucleoside 5'-monophosphates was also observed. Competition studies indicated that a single uptake system with a higher affinity for deoxyribonucleotides mediates the uptake of nucleoside 5'-monophosphates.
D001692:Biological Transport / Q000187:drug effects; D003853:Deoxyribonucleosides / Q000494:pharmacology; D003854:Deoxyribonucleotides / Q000378:metabolism* / Q000494:pharmacology; D007700:Kinetics; D009176:Mycoplasma mycoides / Q000378:metabolism*; D010761:Phosphorus Radioisotopes; D012265:Ribonucleotides / Q000494:pharmacology; D013329:Structure-Activity Relationship
D003853:Deoxyribonucleosides; D003854:Deoxyribonucleotides; D010761:Phosphorus Radioisotopes; D012265:Ribonucleotides