Effect of decreased renal function on the pharmacokinetics of ceftazidime.
The pharmacokinetics of ceftazidime after a 1-g bolus dose were studied in 11 subjects, with creatinine clearances ranging from 113 to 6 ml/min. Concentrations of ceftazidime in serum were determined by microbiological assay. These data were fitted to a two-compartment open model, and pharmacokinetic parameters were calculated. Correlation of ceftazidime clearance with creatinine clearance was excellent (r = 0.99).
D000328:Adult; D000368:Aged; D002442:Ceftazidime; D002511:Cephalosporins / Q000097:blood / Q000378:metabolism*; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006207:Half-Life; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors
D002511:Cephalosporins; D002442:Ceftazidime; D003404:Creatinine