Cold-reacting IgM antibody-induced renal allograft failure. Similarity to hyperacute rejection.
Hyperacute rejection of renal allografts is usually mediated by IgG antibody, but recent studies indicate that cold-reacting IgM alloantibodies are also associated with immediate malfunction of renal allografts. We report 2 cases of cold-reacting IgM-mediated allograft malfunction in which immediate posttransplant biopsies resembled hyperacute rejection. This reaction can probably be prevented by warming the kidney just before transplantation.
D000208:Acute Disease; D000328:Adult; D000373:Agglutinins / Q000276:immunology; D001706:Biopsy; D003080:Cold Temperature; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D007518:Isoantibodies / Q000276:immunology; D007668:Kidney / Q000276:immunology; D007678:Kidney Glomerulus / Q000473:pathology; D016030:Kidney Transplantation; D008297:Male
D000373:Agglutinins; D007075:Immunoglobulin M; D007518:Isoantibodies