Dietary protein: a trigger of insulin-dependent diabetes in the BB rat?
Animals from a colony of spontaneously diabetic insulin-dependent BB rats were fed from weaning with semi-synthetic diets in which natural proteins were replaced by l-amino acids with or without the addition of either milk or wheat proteins. The normal 50% incidence of diabetes in the colony was reduced to 15% in rats fed the basic semi-synthetic diet, while it was 35% and 52% when supplemented with gluten or milk, respectively. Thus, dietary factors might precipitate the expression of the disease.
D000367:Age Factors; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004044:Dietary Proteins / Q000378:metabolism*; D005260:Female; D007328:Insulin / Q000097:blood*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D001786:Blood Glucose; D004044:Dietary Proteins; D007328:Insulin