Effects of bepridil on the resting electrocardiogram.
We evaluated the effects of bepridil hydrochloride, a long-acting calcium antagonist, on the electrocardiogram of 13 men with exertional angina. The drug decreased sinus rate (P = 0.01), increased the QT (P less than 0.001) and QTc interval (P less than 0.001), and produced T-wave changes in each patient.
D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D015764:Bepridil; D002986:Clinical Trials as Topic; D003327:Coronary Disease / Q000188:drug therapy; D004311:Double-Blind Method; D004562:Electrocardiography; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D011759:Pyrrolidines / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D011759:Pyrrolidines; D015764:Bepridil