[Eosinophilic spongiosis and ICS antibodies in a child with strophulus-like dermatosis].
Eosinophilic spongiosis associated with in vivo-bound antibodies to the epidermal intercellular space (ICS) were consistently observed in a recurrent strophulus-like eruption in an 11-year-old boy, thus suggesting pemphigus. The clinical course, however, ruled this diagnosis out since neither acantholysis nor the clinical picture of pemphigus developed in a period of 2.5 years. Since in vivo-bound ICS-antibodies have been described in several case reports of bullous impetigo we speculate that immune reactions to bacterial antigens may be involved in producing eruptions mimicking pemphigus vulgaris.
D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D003937:Diagnosis, Differential; D004802:Eosinophilia; D006801:Humans; D008297:Male; D010392:Pemphigus / Q000175:diagnosis; D012872:Skin Diseases, Vesiculobullous / Q000175:diagnosis / Q000276:immunology*
D001323:Autoantibodies
Eosinophile Spongiose und ICS-Antikörper bei einem Kind mit strophulusartiger Dermatose.