title: Abrupt withdrawal of verapamil in ischaemic heart disease. The Danish Study Group on Verapamil in Myocardial Infarction.
abstract: In order to examine the potential hazards of abrupt withdrawal of verapamil 120 mg t.i.d. after six months treatment, a double blind placebo controlled study was designed as part of the Danish multicenter trial of verapamil in acute myocardial infarction. All patients had had a myocardial infarction six months before withdrawal. At the time of withdrawal, 30% of the verapamil and 28% of the placebo treated patients were experiencing angina pectoris. At follow-up after two to three weeks 15% of 212 patients in the verapamil treated group and 9% of 260 patients in the placebo treated group reported worsening or reappearance of angina pectoris (P less than 0.05). One patient in the placebo group developed a myocardial infarction, and one patient in the verapamil group had episodes of supraventricular tachycardia after withdrawal. A 'withdrawal syndrome' was not found.
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D013375:Substance Withdrawal Syndrome / Q000209:etiology; D014700:Verapamil / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D014700:Verapamil