Glucoprivic responsivity after insulin in hypodipsic and in water deficit rats.
Long Evans rats were made acutely hypodipsic through quinine adulteration of their water supply, and they ate normally in response to 2, 4, and 6 unit insulin injections. Other subjects were made chronically hypodipsic through adulteration; and while their glucoprivic feeding was lowered absolutely, it remained relatively elevated over their control session intake. These data indicate that subjects with reduced drinking abilities can respond to the insulin-induced glucoprivic challenge and that hydrational factors apparently do not serve as critical confounds in brain lesion investigations into the glucoprivic feeding response.
D000818:Animals; D004326:Drinking; D004435:Eating; D007328:Insulin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013894:Thirst / Q000502:physiology*; D014868:Water Deprivation / Q000502:physiology*
D007328:Insulin