Glycosylated haemoglobin: measurement and clinical use.
The discovery, biochemistry, laboratory determination, and clinical application of glycosylated haemoglobins are reviewed. Sources of error are discussed in detail. No single assay method is suitable for all purposes, and in the foreseeable future generally acceptable standards and reference ranges are unlikely to be agreed. Each laboratory must establish its own. Nevertheless, the development of glycosylated haemoglobin assays is an important advance. They offer the best available means of assessing diabetic control.
D001786:Blood Glucose / Q000378:metabolism; D001800:Blood Specimen Collection; D002648:Child; D002846:Chromatography, Affinity; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D003124:Colorimetry; D003920:Diabetes Mellitus / Q000097:blood*; D003951:Diagnostic Errors; D004586:Electrophoresis; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D007003:Hypoglycemia / Q000097:blood; D007525:Isoelectric Focusing; D007700:Kinetics; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood; D011863:Radioimmunoassay
D001786:Blood Glucose; D006442:Glycated Hemoglobin