Properties of murine anti-morphine antibodies.
Four lines of high affinity monoclonal antibodies directed against morphine have been isolated and affinity purified. Some of their properties, including cross-reactivities to a large set of selected opiate agonists and antagonists are described. Importantly, none of the immunoglobulins cross-react with D-Ala2-D-Leu5-enkephalin.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D002846:Chromatography, Affinity; D003429:Cross Reactions; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000276:immunology; D016308:Enkephalin, Leucine-2-Alanine; D005260:Female; D007074:Immunoglobulin G / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009020:Morphine / Q000276:immunology*; D009292:Narcotic Antagonists / Q000276:immunology
D000911:Antibodies, Monoclonal; D007074:Immunoglobulin G; D009292:Narcotic Antagonists; D004743:Enkephalin, Leucine; D016308:Enkephalin, Leucine-2-Alanine; D009020:Morphine