title: Sham feeding is inhibited by dietary-induced obesity in rats.
abstract: A group of six female, albino rats were maintained on a cafeteria diet of cookies, milk, and elevated-fat (shortening), rat-chow mixture and rat chow while a similar group received only rat chow ad lib for 17 weeks. When the groups differed significantly in mean body weight (obese-387.5 g, controls-287.2 g; p less than 0.001), gastric fistulas were implanted in each animal. After recovery, the rats were adapted to a liquid diet and assessed for sham feeding. Control-fed, normal-body-weight subjects showed substantial sham feeding when ingesting the Vivonex with the fistulas open compared to fistula-closed intake; meal frequency, meal size (apart from the initial meal) and total food intake were significantly increased while the satiety ratios following each meal were significantly decreased. Obese animals showed no significant increased feeding and satiety ratios were unreliably altered; while normal-body-weight controls increased 4-hr food intakes by 93% and halved their mean satiety ratios the obese animals showed an 8% increase in 4-hr food intake and only a 22% decrease in mean satiety ratios. We offer the hypothesis that, when animals are induced to become obese by palatable and varied diets which are then terminated, the anorexia produced is independent of gastrointestinal interactions inasmuch as that anorexia extends to sham feeding.
mesh_terms: D000818:Animals; D000855:Anorexia / Q000209:etiology; D001835:Body Weight; D004032:Diet; D004435:Eating; D005247:Feeding Behavior; D005260:Female; D005747:Gastric Fistula; D007328:Insulin / Q000097:blood; D009765:Obesity; D051381:Rats; D011919:Rats, Inbred Strains; D012527:Satiation
chemical_list: D007328:Insulin