title: Experimental evaluation of the resistance of the skin grafted rectum to ileal contents.
abstract: There are three general approaches to prevent the development of cancer in patients with premalignant colorectal diseases. One method requires total colectomy and excision of the rectal mucous membrane. For 35 years, patients have had their rectal muscle tube covered by a variety of full-thickness ileal pullthrough operations. For 30 years, various types of pelvic ileal pouches have been tried in attempts to improve bowel function. This report attempts to evaluate another approach in experimental animals. The rectal submucosa was skin grafted and subsequently anastomosed to the ileum to assess its ability to stand up to that milieu. The results were promising with a maximum follow-up of 1 year. This may prove to be another option to ileoanastomy with or without a pouch.
mesh_terms: D001003:Anal Canal / Q000601:surgery; D000818:Animals; D003082:Colectomy; D004285:Dogs; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007081:Ileostomy / Q000379:methods; D007082:Ileum / Q000601:surgery; D007417:Intestinal Polyps / Q000601:surgery; D019736:Prostheses and Implants; D012004:Rectal Neoplasms / Q000517:prevention & control; D012007:Rectum / Q000601:surgery*; D016038:Skin Transplantation; D013536:Suture Techniques