Characterization of antineurofilament autoantibodies in Creutzfeldt-Jakob disease.
The antineurofilament antibodies found in the serum of a chimpanzee with experimental Creutzfeldt-Jakob disease reacted specifically with the 200,000-dalton polypeptide of the purified neurofilament triplet. They also reacted strongly with thoroughly characterized neurofilament swellings of proximal axons of spinal cord motoneurons from beta,beta' iminodipropionitrile (IDPN)-intoxicated rats.
D000818:Animals; D001323:Autoantibodies / Q000032:analysis*; D007562:Creutzfeldt-Jakob Syndrome / Q000276:immunology* / Q000473:pathology; D003599:Cytoskeleton / Q000276:immunology* / Q000473:pathology; D006801:Humans; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000473:pathology
D001323:Autoantibodies