title: The effects of dietary gum tragacanth in man.
abstract: Following a 7-day control period, 5 male volunteers consumed 9.9 g gum tragacanth (GT) daily for 21 days. The GT was well tolerated and there were no adverse effects in any of the volunteers. The daily intake was very high in relation to the minor amounts of GT (estimated at 2 g per person per annum) likely to be ingested as a foodstuffs additive. The wide range of measurements made before and at the end of the test period show that the ingestion of GT had no significant effect on any of the following: plasma biochemistry; haematological indices; urinalysis parameters; glucose tolerance; serum cholesterol, triglycerides and phospholipids; breath hydrogen and methane concentrations. The intestinal transit time decreased and faecal fat concentration increased (P less than 0.01) for 4 subjects. The faecal wet and dry weights increased in all subjects (P less than 0.01). These changes may be of nutritional and physiological interest but do not reflect any adverse toxicological effects arising from the ingestion of large daily doses of GT.
mesh_terms: D000328:Adult; D001774:Blood Chemical Analysis; D001786:Blood Glucose / Q000032:analysis; D004032:Diet; D005243:Feces / Q000032:analysis; D005503:Food Additives / Q000633:toxicity*; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007328:Insulin / Q000097:blood; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D011134:Polysaccharides / Q000008:administration & dosage*; D014144:Tragacanth / Q000008:administration & dosage* / Q000633:toxicity
chemical_list: D001786:Blood Glucose; D005503:Food Additives; D007328:Insulin; D008055:Lipids; D011134:Polysaccharides; D014144:Tragacanth