A comparison of oxytetracycline and trimethoprim in the treatment of Chlamydia trachomatis urethritis.
The effect of trimethoprim was compared with that of oxytetracycline in the treatment of uncomplicated urethritis and/or cervicitis. Twenty-six patients treated with oxytetracycline were all microbiologically cured. Of 19 patients treated with trimethoprim, ten (53%) still harboured the chlamydia after two weeks. The superiority of tetracycline was even more pronounced following the evaluation of dysuria and discharges. 85% of the patients treated with oxytetracycline and 6% of those treated with trimethoprim had neither dysuria nor discharge after the completion of treatment. The patients who failed to be cured by trimethoprim were all successfully treated with oxytetracycline.
D000328:Adult; D002690:Chlamydia Infections / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D010118:Oxytetracycline / Q000627:therapeutic use*; D011897:Random Allocation; D014295:Trimethoprim / Q000627:therapeutic use*; D014526:Urethritis / Q000188:drug therapy* / Q000209:etiology; D002575:Uterine Cervicitis / Q000188:drug therapy* / Q000209:etiology
D014295:Trimethoprim; D010118:Oxytetracycline