Development of immune complex nephritis during treatment with the calcium channel-blocking agent nifedipine.
Following multiple myocardial infarctions, a patient was treated with the calcium channel-blocking agent nifedipine. Within three months he had proteinuria of up to 460 mg/24 hours. Renal biopsy showed an immune complex glomerulonephritis. The presence of microfibrils was associated with the capillary basement membrane and mesangial changes.
D000936:Antigen-Antibody Complex; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000139:chemically induced* / Q000276:immunology; D006801:Humans; D007668:Kidney / Q000473:pathology; D007678:Kidney Glomerulus / Q000276:immunology / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy; D009543:Nifedipine / Q000009:adverse effects* / Q000627:therapeutic use; D014700:Verapamil / Q000627:therapeutic use
D000936:Antigen-Antibody Complex; D014700:Verapamil; D009543:Nifedipine