The cytotoxic action in vitro of catalytically sulphurated unsaturated fatty acids on Ehrlich's ascites cancer and normal peritoneal exudate (leucocytes).
Diethanolamine salts of the catalytically sulphurated oleic acid (X-303/1) and of the catalytically sulphurated fatty acids isolated from linseed oil (X-303/2) were found to exhibit a strong cytotoxic in vitro activity against Ehrlich ascites cancer cells with minimal cytotoxic effect on normal cells (leukocytes) of the peritoneal exudate in rabbits.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D055598:Chemical Phenomena; D002621:Chemistry; D005122:Exudates and Transudates / Q000166:cytology; D005231:Fatty Acids, Unsaturated / Q000138:chemical synthesis / Q000494:pharmacology*; D007962:Leukocytes / Q000187:drug effects; D008043:Linseed Oil / Q000494:pharmacology; D051379:Mice; D019301:Oleic Acid; D009829:Oleic Acids / Q000494:pharmacology
D005231:Fatty Acids, Unsaturated; D009829:Oleic Acids; D019301:Oleic Acid; D008043:Linseed Oil