Diabetic lipohypertrophy delays insulin absorption.
The effect of lipohypertrophy at injection sites on insulin absorption has been studied in 12 insulin-dependent diabetic patients. The clearance of 125I-insulin from sites with lipohypertrophy was significantly slower than from complementary nonhypertrophied sites (% clearance in 3 h, 43.8 +/- 3.5 +/- SEM) control; 35.3 +/- 3.9 lipohypertrophy, P less than 0.05). The degree of the effect was variable but sufficient in several patients to be of clinical importance. Injection-site lipohypertrophy is another factor that modifies the absorption of subcutaneously injected insulin.
D000273:Adipose Tissue / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D006984:Hypertrophy; D007328:Insulin / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism*; D008297:Male; D012869:Skin Absorption
D007328:Insulin