title: Immunoreactive arginine-vasopressin in Brattleboro rat ovary.
abstract: Homozygous (di/di) Brattleboro rats have normal hypothalamic levels of oxytocin and neurophysin I, but undetectable levels of neurophysin II and arginine-vasopressin (AVP). This defect has been presumed to be at the genomic or transcriptional level, as AVP messenger is reported to be drastically reduced, if not absent, from the hypothalamus of Brattleboro rats. Recent studies suggest de novo production of various neuropeptides in the mammalian gonad, including AVP. We report here the detection and localization of immunoreactive (ir) AVP in the luteal cells of adult homozygous Brattleboro rats, and the modulation of this ovarian ir-AVP by gonadotropins. These findings are thus consistent with a tissue-specific defect of AVP expression in the magnocellular neurones of the Brattleboro rat, and suggest that a comparable defect does not occur in the ovaries of such animals.
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D005455:Fluorescent Antibody Technique; D006720:Homozygote; D007031:Hypothalamus / Q000032:analysis; D010053:Ovary / Q000032:analysis*; D010902:Pituitary Gland / Q000032:analysis; D051381:Rats; D011910:Rats, Brattleboro / Q000502:physiology*; D011922:Rats, Mutant Strains / Q000502:physiology*; D013045:Species Specificity; D014018:Tissue Distribution
chemical_list: D001127:Arginine Vasopressin