title: Trazodone, a review of clinical literature and personal experience.
abstract: The authors summarize the international clinical research performed on trazodone, underlying some pharmacodynamic and therapeutic features of the activity of the drug, the originality of its pharmacodynamic profile and the possibility of using trazodone in a wide range of primary or secondary depression subtypes. Available data also suggest that trazodone is safer than traditional antidepressants even when taken in overdose, possibly due to its mild effects on cardiac or ventilatory function.
mesh_terms: D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy*; D004361:Drug Tolerance; D004562:Electrocardiography; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D010879:Piperazines / Q000627:therapeutic use*; D011941:Receptors, Adrenergic / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D014196:Trazodone / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D010879:Piperazines; D011941:Receptors, Adrenergic; D011985:Receptors, Serotonin; D014196:Trazodone