Rutoside and the X-ray induced damage in jejunal mucosa of mouse.
The effect of O-(beta-hydroxyethyl)-Rutoside on the radiation response of mouse small intestine was investigated. The post-irradiation mitotic regeneration in jejunal crypts, the survival of crypt stem cells and the post-irradiation mortality of animals were taken as criteria. Multiple treatment with rutoside (300 mg/kg/injection) combined with a whole-body-X-irradiation failed to show protective effect in all the cases studied. Some possibilities which may explain these results are presented.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006896:Hydroxyethylrutoside / Q000627:therapeutic use*; D007413:Intestinal Mucosa / Q000528:radiation effects; D007583:Jejunum / Q000528:radiation effects*; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D011832:Radiation Injuries / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D012431:Rutin / Q000031:analogs & derivatives*; D014916:Whole-Body Irradiation
D006896:Hydroxyethylrutoside; D011837:Radiation-Protective Agents; D012431:Rutin