Effect of butylated hydroxytoluene and butylated hydroxyanisole on the mutagenicity of 3,2'-dimethyl-4-aminobiphenyl.
This study was undertaken to investigate the possible antimutagenic effects of butylated hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) on 3,2'-dimethyl-4-aminobiphenyl (DMAB)-induced mutagenicity, using the Ames Salmonella/mammalian microsome system. The addition of 100-250 micrograms of BHT or 25-500 micrograms of BHA/plate was found to inhibit DMAB-induced mutagenicity in Salmonella strains TA 98 and TA 100. In TA 100, the mutagenicity was further inhibited with the addition of S9 prepared from the livers of rats fed a 0.6% BHT diet as compared to S9 from the animals fed a diet containing no BHT.
D000611:Aminobiphenyl Compounds; D000814:Aniline Compounds / Q000037:antagonists & inhibitors*; D000818:Animals; D002083:Butylated Hydroxyanisole / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000378:metabolism / Q000494:pharmacology*; D004159:Diphenylamine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors*; D008099:Liver / Q000378:metabolism; D008110:Liver Extracts / Q000494:pharmacology; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens; D051381:Rats; D011916:Rats, Inbred F344; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D000611:Aminobiphenyl Compounds; D000814:Aniline Compounds; D008110:Liver Extracts; D009153:Mutagens; C001042:2',3-dimethyl-4-aminobiphenyl; D002084:Butylated Hydroxytoluene; D002083:Butylated Hydroxyanisole; D004159:Diphenylamine