Combined effects of chemotherapy and host antitumor response in a murine histocompatible lymphoma model.
Combined effects of 1,3-bis-(2-chloroethyl)-1-nitrosourea (BCNU) and host antitumor immune response were studied in mice inoculated intraperitoneally with histocompatible LSTRA leukemia cells carrying virus-induced transplantation antigens. Marked chemo-immune collaborative activity was found to occur when selected schedules of BCNU administration were employed. Moreover, synergist effects were also detected between chemotherapy and both specific and non-specific immunotherapy.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002176:Candida albicans / Q000276:immunology; D002330:Carmustine / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005657:Fungal Vaccines / Q000627:therapeutic use; D006649:Histocompatibility Antigens / Q000032:analysis*; D007167:Immunotherapy; D008223:Lymphoma / Q000188:drug therapy / Q000276:immunology* / Q000628:therapy; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation
D000970:Antineoplastic Agents; D005657:Fungal Vaccines; D006649:Histocompatibility Antigens; D002330:Carmustine