title: Effect of bacterial lipopolysaccharide on serum high density lipoprotein cholesterol in rabbits.
abstract: The effect of bacterial lipopolysaccharide (LPS) on serum lipids was examined in rabbits. LPS was prepared from the smooth Salmonella typhimurium LT2 strain and given intravenously at a dose of 100 ng/kg b.wt. There were no significant changes in serum triglyceride or cholesterol levels in 1-3 days after the administration of LPS. There was, however, a decrease in serum high density lipoprotein (HDL) cholesterol, which was greatest after 2 days (P less than 0.001). Simultaneously, the HDL/total cholesterol ratio decreased (P less than 0.005).
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D011817:Rabbits; D012486:Salmonella typhimurium; D014280:Triglycerides / Q000097:blood
chemical_list: D008076:Cholesterol, HDL; D008070:Lipopolysaccharides; D008075:Lipoproteins, HDL; D014280:Triglycerides; D002784:Cholesterol