Sarin poisoning in guinea pigs compared to reactivation of acetylcholinesterase in vitro as a basis for therapy.
Contrary to the large number of publications dealing with treatment of organophosphate poisoning in a variety of animal species, there is no logic reason in the preference of one species, for this purpose. Guinea pigs were reported to respond better to treatment by oximes, than mice and rats. However, in the analysis of data on the effect of obidoxim and atropine or benactyzine on sarin poisoning it is demonstrated, that guinea pigs do not respond differently from mice and rats. Subcutaneous LD50's of sarin in mice ranged from 0.06 to 0.207 mg/kg, and those of guinea pigs from 0.04 to 0.112 mg/kg. The difference in the LD50's may be related to the different susceptibility of various animal species. The importance of "in vivo" dosage, mode of application, kinetics of antagonists, in correlation to the ability to reactivate "in vitro" is discussed.
D000110:Acetylcholinesterase; D000818:Animals; D002801:Cholinesterase Reactivators / Q000627:therapeutic use*; D005260:Female; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008297:Male; D009768:Obidoxime Chloride / Q000627:therapeutic use; D062025:Organophosphate Poisoning; D012524:Sarin / Q000008:administration & dosage / Q000506:poisoning*; D013045:Species Specificity
D002801:Cholinesterase Reactivators; D009768:Obidoxime Chloride; D012524:Sarin; D000110:Acetylcholinesterase