title: Inhibition of non-specific leukocyte esterase activity. Absence of monocyte esterase activity due to phosphoric and thiophosphoric acid ester intoxication.
abstract: In vitro evaluation of the effect of five insecticidal phosphoric and 11 thiophosphoric acid esters on different, non-specific human leukocytes esterases indicated that most of the organic phosphor compounds studied inhibited the activity of neutral alpha-naphthylacetate esterase, alpha-naphthylbutyryl esterase, and naphthol AS acetate esterase, i.e. the monocyte esterases. The extent of inhibition was dose dependent; the inhibiting dose being identical for the various non-specific esterases. Reactivation with Obidoxim was not successful. Monocyte esterase activity in a human survivor of E 605 intoxication was detectable only after serum acetylcholinesterase had returned to normal levels. The organic phosphor compound studied, however, inhibited neither acid alpha-naphthylacetate esterase nor naphthol AS-D chloroacetate esterase activity.
mesh_terms: D000293:Adolescent; D004793:Enzyme Reactivators / Q000494:pharmacology; D004950:Esterases / Q000037:antagonists & inhibitors*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007306:Insecticides / Q000506:poisoning*; D007962:Leukocytes / Q000187:drug effects / Q000201:enzymology*; D009000:Monocytes / Q000187:drug effects / Q000201:enzymology*; D009768:Obidoxime Chloride / Q000494:pharmacology / Q000627:therapeutic use; D010278:Parathion / Q000506:poisoning; D013997:Time Factors
chemical_list: D004793:Enzyme Reactivators; D007306:Insecticides; D009768:Obidoxime Chloride; D010278:Parathion; D004950:Esterases