title: Double-blind comparisons of slow-release theophylline, ketotifen and placebo for prophylaxis of asthma in young children.
abstract: Clinical trials of slow-release theophylline and ketotifen as prophylaxis against asthma in 18 young children suggested that both drugs had some efficacy. The theophylline was more effective and produced reduction in salbutamol usage as well as an increase in peak expiratory flow rates. Transient nausea and vomiting was commoner during theophylline treatment but did not usually necessitate discontinuing therapy.
mesh_terms: D001249:Asthma / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007223:Infant; D007665:Ketotifen / Q000627:therapeutic use*; D008297:Male; D013806:Theophylline / Q000627:therapeutic use*
chemical_list: D003692:Delayed-Action Preparations; D013806:Theophylline; D007665:Ketotifen