[Action of diucifon-treated syngeneic splenic cells of mice on the magnitude of the immune response].
It was demonstrated previously that treatment of lymphocytes with the immunostimulant diucifon leads to the secretion of a substance having the biological activity of T cell growth factor. The present work demonstrates that injection into mice on the day of immunization of spleen syngeneic cells treated with diucifon increases the immune response 3-5-fold as compared to the action of untreated cells. Injection of spleen cells incubated without diucifon on day 3 after immunization significantly increases the immune response as compared with control. The cells treated with diucifon and injected at the same time reduce the immune response as compared with the action of spleen cells incubated without diucifon. The data obtained can be used during immunostimulant therapy.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D004338:Drug Combinations / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000187:drug effects* / Q000276:immunology / Q000637:transplantation; D013450:Sulfones / Q000276:immunology*; D013997:Time Factors; D014185:Transplantation, Isogeneic; D014498:Uracil / Q000031:analogs & derivatives* / Q000276:immunology
D000276:Adjuvants, Immunologic; D004338:Drug Combinations; D013450:Sulfones; C023367:diucifon; D014498:Uracil
Issledovanie deĭstviia singennykh kletok selezenki mysheĭ, obrabotannykh diutsifonom, na velichinu immunnogo otveta.