title: Loss of HLA-DR expression by human epidermal cells after growth in culture.
abstract: These studies present evidence that when human epidermal cells are grown in culture they lose both the ability to stimulate the proliferation of allogeneic T lymphocytes in vitro and their expression of HLA-DR antigens. Our results also show that epidermal cells incubated with anti-HLA-DR serum lose their ability to stimulate the proliferation to allogeneic T lymphocytes in a mixed skin cell-lymphocyte reaction.
mesh_terms: D015214:Antigens, Differentiation, Myelomonocytic; D000954:Antigens, Surface / Q000032:analysis; D002478:Cells, Cultured; D004817:Epidermis / Q000648:ultrastructure; D005455:Fluorescent Antibody Technique; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007700:Kinetics; D008854:Microscopy, Electron; D012867:Skin / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
chemical_list: D015214:Antigens, Differentiation, Myelomonocytic; D000954:Antigens, Surface; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; C041878:Mac-120 antigen, human