[Interaction of atropine, toxogonin and fosfakol].
Protective action of atropine and toxogonin against phosphacol poisoning has been studied in experiments on white mice. The protective effect has been shown to depend on the magnitude of the doses combined. The most powerful is the combination that provides for the effect potentiation (30-200 mg/kg atropine, 5-70 mg/kg toxogonin). When toxogonin was applied in a dose of 100 mg/kg and higher, atropine addition lowered the ability to prevent phosphacol poisoning, with this effect being more powerful the higher the dose. Between the zones of potentiation and antagonism there is a zone within which the prophylactic actions of both drug doses are summed up.
D000818:Animals; D000931:Antidotes / Q000008:administration & dosage; D001285:Atropine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009768:Obidoxime Chloride / Q000008:administration & dosage*; D010091:Oximes / Q000008:administration & dosage*; D010261:Paraoxon / Q000506:poisoning*
D000931:Antidotes; D010091:Oximes; D009768:Obidoxime Chloride; D001285:Atropine; D010261:Paraoxon
Izuchenie vzaimodeĭstviia atropina, toksogonina i fosfakola.