The PM distribution: a model for interpreting LD isoenzyme patterns.
We present a method for inferring from the lactate dehydrogenase (LD) isoenzyme pattern in serum or interstitial fluid the estimated distribution of a cellular parameter PM in the cell population from which LD was released. PM is defined as the fraction of M monomer (one of two gene products which may serve as subunits of the LD tetramer) available in a particular cell. The distribution of PM represents a more fundamental characterization of cellular biochemistry than the serum LD pattern. We apply the method to LD patterns from the literature and illustrate the advantage of this approach over simple inspection or piece-by-piece statistical analysis of LD patterns.
D000818:Animals; D001011:Aorta / Q000201:enzymology; D001161:Arteriosclerosis / Q000201:enzymology; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D005333:Fetus / Q000187:drug effects / Q000201:enzymology; D006084:Graft Rejection; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000378:metabolism*; D016040:Lung Transplantation; D008433:Mathematics; D051379:Mice; D008954:Models, Biological
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase