[Treatment of patients with exercise-induced angina pectoris with korinfar and isoptin].
Forty-eight patients with stable angina of effort of II and III functional classes were investigated to compare the efficacy of the calcium antagonists corinfar and isoptin, using placebo and a simple cross-over design of the study. The two drugs were found to have a high antianginal effect expressed in a statistically significant reduction of the incidence of anginal attacks and an increased tolerance to load as compared to placebo. The degree of the antianginal action of corinfar in a daily dose of 40 mg and isoptin in a dose of 240 mg was approximately the same. In some patients the antianginal effect of corinfar and isoptin was associated with an elevation in the pulse-pressure index at the peak of the load, which may be accounted for by the direct coronarodilatory action of these drugs.
D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy* / Q000209:etiology; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D010919:Placebos; D011674:Pulse / Q000187:drug effects; D012107:Research Design; D014700:Verapamil / Q000627:therapeutic use*
D002121:Calcium Channel Blockers; D010919:Placebos; D014700:Verapamil
Lechenie bol'nykh so stenokardieĭ napriazheniia korinfarom i izoptinom.