Purpura fulminans following late-onset group B beta-hemolytic streptococcal sepsis.
A 16-day-old male infant initially was in septic shock. Following intensive resuscitation, thrombohemorrhagic lesions developed over his extremities, except for the limb with an arterial line maintained by a continuous heparin sodium infusion. Blood and CSF cultures yielded group B beta-hemolytic streptococci. Results of laboratory studies and clinical appearance supported the diagnosis of purpura fulminans (PF). Systemic heparinization was therefore started, and subsequently his condition improved. Because of the distinct difference in limb sparing, we concluded heparin has a beneficial effect on the evolution of PF.
D001132:Arm / Q000098:blood supply; D005734:Gangrene / Q000209:etiology; D006493:Heparin / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007261:Infusions, Intra-Arterial; D007866:Leg / Q000098:blood supply; D008297:Male; D009336:Necrosis / Q000209:etiology; D011693:Purpura / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D013290:Streptococcal Infections / Q000150:complications*; D013292:Streptococcus agalactiae; D013927:Thrombosis / Q000188:drug therapy / Q000209:etiology*
D006493:Heparin