title: Polymorphonuclear leukocyte chemotaxis by mixed anaerobic and aerobic bacteria.
abstract: The induction of chemotactic activity of polymorphonuclear leukocytes (PMNL) by anaerobic and aerobic bacteria alone or in combination was evaluated. Washed cells as well as the supernate of Proteus mirabilis were chemotactic for leukocytes. The supernate of cultures of two strains of Bacteroides fragilis contained small amounts of chemotactic factors. No chemotactic factors were released from the non-fragilis Bacteroides strains. The supernates of cultures of anaerobic bacteria were capable of inhibiting chemotaxis of leukocytes to the chemotactic factors of P. mirabilis. P. mirabilis and two strains of B. fragilis generated chemotactic factors in serum but none of the other Bacteroides spp. tested were able to induce serum chemotactic factors.
mesh_terms: D000328:Adult; D001439:Bacteroides / Q000502:physiology*; D001441:Bacteroides fragilis / Q000502:physiology; D002630:Chemotactic Factors / Q000097:blood*; D002634:Chemotaxis, Leukocyte; D006358:Hot Temperature; D006801:Humans; D066298:In Vitro Techniques; D016209:Interleukin-8; D009504:Neutrophils / Q000502:physiology*; D011513:Proteus mirabilis / Q000502:physiology*
chemical_list: D002630:Chemotactic Factors; D016209:Interleukin-8