Acute effect of captopril on serum lipid peroxides level in hypertensive patients.
Captopril, an orally active angiotensin-converting enzyme inhibitor, was administered to 15 patients with essential hypertension. The serum lipid peroxides level, aldosterone concentration in plasma and blood pressure decreased rapidly after administration, while plasma renin activity was not significantly changed. It is suggested that inhibition of angiotensin-converting enzyme by captopril offers a possible therapeutic approach to the treatment of atherosclerosis complicated with hypertension.
D000328:Adult; D000450:Aldosterone / Q000097:blood; D002216:Captopril / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D008054:Lipid Peroxides / Q000097:blood*; D008297:Male; D011392:Proline / Q000031:analogs & derivatives*; D012084:Renin-Angiotensin System / Q000187:drug effects
D008054:Lipid Peroxides; D000450:Aldosterone; D011392:Proline; D002216:Captopril