Study on B-memory generation by Tnp-Ficoll: induction but not expression is observed among various inbred mouse strains.
The primary and secondary responses to Tnp-Ficoll, a class 2 thymus-independent antigen, were assessed in various inbred strains of mice. The eventual implication of H-2 or IgH linked genes was searched for. Contrasting with our previous reports using Tnp-LPS, a class 1 thymus-independent antigen, no homologous memory-type response to Tnp-Ficoll and consequently no genetic control was observed. However Tnp-specific B-memory lymphocytes were induced in most strains since a heterologous challenge with Tnp-LPS evoked a typical memory type response characterized by an increased number of antibody-secreting cells and/or significant amount of anti-Tnp antibodies of the IgG isotype. The lack of memory revelation by Tnp-Ficoll is discussed in terms of a possible humoral or cellular regulation and of B-memory cell generation and maturation.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D000955:Antigens, T-Independent / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D005362:Ficoll / Q000031:analogs & derivatives / Q000276:immunology / Q000494:pharmacology*; D006462:Hemolytic Plaque Technique; D007156:Immunologic Memory; D008070:Lipopolysaccharides / Q000276:immunology / Q000494:pharmacology; D008213:Lymphocyte Activation; D051379:Mice; D008805:Mice, Inbred A; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D009578:Nitrobenzenes / Q000494:pharmacology*; D011134:Polysaccharides / Q000494:pharmacology*; D014301:Trinitrobenzenes / Q000276:immunology / Q000494:pharmacology*
D000955:Antigens, T-Independent; D008070:Lipopolysaccharides; D009578:Nitrobenzenes; D011134:Polysaccharides; C020529:TNP-ficoll; D014301:Trinitrobenzenes; D005362:Ficoll