The role of insulin, corticosterone and other factors in the acute recovery of muscle protein synthesis on refeeding food-deprived rats.
Measurements of changes in muscle protein synthesis, insulin and corticosterone in vivo in refed food-deprived rats, some after pretreatment with anti-insulin serum or corticosterone, indicate that the acute increase in protein synthesis (20-40 min) requires (a) insulin, (b) a fall in corticosterone, since corticosterone acts at least in part by blocking insulin action, and (c) at least one other independent anabolic factor.
D000818:Animals; D003345:Corticosterone / Q000097:blood* / Q000494:pharmacology; D005502:Food; D005508:Food Deprivation / Q000502:physiology*; D007328:Insulin / Q000097:blood* / Q000502:physiology; D007330:Insulin Antibodies; D008297:Male; D009124:Muscle Proteins / Q000096:biosynthesis*; D009132:Muscles / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D007330:Insulin Antibodies; D009124:Muscle Proteins; D003345:Corticosterone