Effect of exogenous surfactant on total respiratory system compliance.
We measured total respiratory system compliance (Crs) before and after instilling 25 mg artificial surfactant in 1 ml saline down the endotracheal tube of preterm babies requiring resuscitation at birth, and compared results with data from 6 similar babies receiving saline only. Surfactant did not produce a significant improvement in Crs.
D002986:Clinical Trials as Topic; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008170:Lung Compliance / Q000187:drug effects*; D011663:Pulmonary Surfactants / Q000494:pharmacology / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000188:drug therapy*; D012137:Respiratory System / Q000187:drug effects; D012151:Resuscitation; D012965:Sodium Chloride / Q000494:pharmacology
D011663:Pulmonary Surfactants; D012965:Sodium Chloride