Effect of insulin on the transformation of BALB/3T3 cells by X-ray irradiation.
The effects of triiodothyronine (T3), hydrocortisone, and insulin on X-ray-induced transformation of BALB/3T3 A31-1-1 cloned cells were examined. Under the experimental conditions employed, the addition of 10(-7) M T3 or hydrocortisone to the serum-containing medium had little effect on the transformation. In contrast, the addition of insulin dramatically enhanced the transformation. The effect of insulin was concentration-dependent up to 10 micrograms/ml and was consistently observed with X-rays at various doses.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000473:pathology; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006854:Hydrocortisone / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D014284:Triiodothyronine / Q000494:pharmacology
D007328:Insulin; D014284:Triiodothyronine; D006854:Hydrocortisone