Adipose tissue lipoprotein-lipase activity in obesity.
The activity of lipoprotein-lipase in heparin-eluates of adipose tissue (AT-LPLA) of three body regions was measured in 22 obese and 18 nonobese females under basal conditions. AT-LPLA in the obese women both before and after 10 d of caloric restriction was also measured. Basal LPLA correlated well with plasma insulin values and reduced significantly after caloric restriction. Relative body weight, body fat, fasting and glucose-stimulated insulin levels, triglycerides, total cholesterol, but not high-density lipoprotein cholesterol, significantly decreased after caloric restriction. Variation of insulin levels after caloric restriction was the best explanatory variable correlating with AT-LPLA variations. These results are consistent with a primary role of insulin in regulating AT-LPLA.
D000273:Adipose Tissue / Q000201:enzymology*; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D004038:Diet, Reducing; D002149:Energy Intake; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008875:Middle Aged; D009765:Obesity / Q000178:diet therapy / Q000201:enzymology*; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D014280:Triglycerides; D008071:Lipoprotein Lipase