title: [Selection, analysis and mapping of mutations in the gene for resistance to kanamycin in plasmid RP4].
abstract: We have tested possibilities of Escherichia coli strains dependent on drugs streptomycin and paromomycin for selection of spontaneous mutations in the RP4 kan gene specifying resistance to aminoglycosids--kanamycin, neomycin and paromycin. A set of kan gene mutations were obtained, classified ad mapped.
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D002874:Chromosome Mapping; D003227:Conjugation, Genetic / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics; D005798:Genes, Bacterial / Q000187:drug effects; D007612:Kanamycin / Q000037:antagonists & inhibitors*; D009154:Mutation; D010403:Penicillin Resistance; D010957:Plasmids / Q000187:drug effects; D012641:Selection, Genetic
chemical_list: D007612:Kanamycin; D000667:Ampicillin
vernacular_title: Selektivnyĭ otbor, analiz i kartirovanie mutatsiĭ v gene ustoĭchivosti k kanamitsinu plazmidy RP4.