Regulation of human lymph contractility by prostaglandins and thromboxane.
Thromboxane A2 (TXA2), but not prostacyclin (PGI2), plays an important role in human lymph vessel contraction. Paradoxically, whereas substantial amounts of PGI2 are detectable in human lymphatics, TXA2 is undetectable and probably derives from surrounding tissues.
D000293:Adolescent; D000328:Adult; D000527:Alprostadil; D011464:Epoprostenol / Q000494:pharmacology; D005260:Female; D006801:Humans; D008208:Lymphatic System / Q000187:drug effects*; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D010646:Phentolamine / Q000494:pharmacology; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology; D044262:Prostaglandin H2; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D011463:Prostaglandins H / Q000494:pharmacology; D013928:Thromboxane A2 / Q000494:pharmacology*; D013931:Thromboxanes / Q000494:pharmacology*
D011450:Prostaglandin Endoperoxides, Synthetic; D011453:Prostaglandins; D011458:Prostaglandins E; D011463:Prostaglandins H; D013931:Thromboxanes; D044262:Prostaglandin H2; D013928:Thromboxane A2; D011464:Epoprostenol; D000527:Alprostadil; D008784:Methysergide; D010646:Phentolamine