Effect of salicylates on intestinal secretion in calves given (intestinal loops) Escherichia coli heat-stable enterotoxin.
The inhibitory effect of salicylates on intestinal secretion in 1- to 5-day-old calves given Escherichia coli heat-stable enterotoxin (ST)-induced intestinal fluid response was investigated. Purified ST was diluted in isotonic saline solution to obtain 1:10, 1:25, 1:50, 1:75, and 1:100 dilutions. Each dilution (1 ml) was inoculated into ligated loops in the distal part of the jejunum of each calf. Acetylsalicylic acid (aspirin) given orally (100 mg/kg) at 4 hours before ST was inoculated did not substantially alter the intestinal fluid response to ST. Sodium salicylate (IV) infusion, begun simultaneously when, or at 1 hour after, ST was inoculated, significantly (P less than 0.05) decreased fluid accumulation in those loops inoculated with ST dilutions of 1:25 or greater. The sodium and potassium concentrations of the accumulated fluid did not differ significantly between or within treatment groups. These results indicate that sodium salicylate infusion may be beneficial in treating enterotoxic colibacillosis in calves. Aspirin given orally at the dose used in the present study, would not have any beneficial effect.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy; D003967:Diarrhea / Q000188:drug therapy / Q000662:veterinary; D004768:Enterotoxins / Q000494:pharmacology*; D004926:Escherichia coli; D007419:Intestinal Secretions / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D009994:Osmolar Concentration; D012459:Salicylates / Q000494:pharmacology* / Q000627:therapeutic use; D020156:Salicylic Acid
D004768:Enterotoxins; D012459:Salicylates; D020156:Salicylic Acid; D001241:Aspirin