Familial amyloidosis. A histopathological study.
Four autopsy cases of familial amyloidosis were reported. The ages of the patients ranged from 37 to 51 years consisting of 3 males and 1 female. They all complained of neurological symptoms. Histologically, amyloid deposition in familial amyloidosis was different in site and grade from that of other types of amyloidosis, showing heavy deposition in nervous and endocrine system but no differences were found referring to deposition in other tissues. Electronmicroscopically, the peripheral nervous tissue was examined and amyloid fibrils were found to be deposited massively in interstices of nerve fiber.
D000328:Adult; D000682:Amyloid / Q000378:metabolism; D000686:Amyloidosis / Q000235:genetics* / Q000473:pathology; D001921:Brain / Q000473:pathology; D004064:Digestive System / Q000473:pathology; D004702:Endocrine Glands / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D009412:Nerve Fibers / Q000648:ultrastructure; D009420:Nervous System / Q000473:pathology; D010375:Pedigree; D013154:Spleen / Q000473:pathology
D000682:Amyloid