Creutzfeldt-Jakob disease: experimental transmission in the guinea pig.
An experimental disease could be serially propagated in the guinea pig by intracerebral inoculation of cerebrospinal fluid or brain suspensions from 8 patients with Creutzfeldt-Jakob disease (CJD). The disease, characterized by tremor, ataxia and convulsions, appeared after a long incubation period (370-420 days). Microscopic lesions and electron optic features were similar to those described in human CJD and in experimental CJD in the chimpanzee.
D000818:Animals; D001921:Brain / Q000473:pathology; D007562:Creutzfeldt-Jakob Syndrome / Q000134:cerebrospinal fluid / Q000473:pathology / Q000635:transmission*; D004195:Disease Models, Animal; D006168:Guinea Pigs; D006801:Humans; D013997:Time Factors