title: Regulation of lymphocyte activation by PGE2 in multiple sclerosis.
abstract: The immunoregulatory action of prostaglandin E2 (PGE2) was examined in two independent lymphocyte activation assays of peripheral blood lymphocytes obtained from multiple sclerosis (MS) patients and normal controls. Phytohaemagglutinin (PHA)-mediated stimulation of lymphoblast transformation and leucocyte migration inhibition factor (LIF) release were both inhibited by PGE2 in a dose-dependent manner. Sixteen patients with MS were studied as a single clinical group and their PHA-stimulated lymphocytes shown to respond essentially normally to PGE2. Four patients in relapse exhibited diminished responsiveness in both assays, but only at a supraphysiological concentration of PGE2. Thus, unresponsiveness to immunoregulatory prostaglandins is unlikely to be a major contribution to the immunopathogenesis of MS.
mesh_terms: D000328:Adult; D015232:Dinoprostone; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007961:Leukocyte Migration-Inhibitory Factors / Q000378:metabolism*; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D008222:Lymphokines / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology*
chemical_list: D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines; D010835:Phytohemagglutinins; D011458:Prostaglandins E; D015232:Dinoprostone