title: Early cellular reactions induced by dinitrochlorobenzene in sensitized human skin.
abstract: Serial biopsies during the first 24 hours after dinitrochlorobenzene (DNCB) challenge in fifteen sensitized patients have shown that DNCB associates with Langerhans cells within I hour of application, and has reached the dermis around the appendages by 6 hours.
mesh_terms: D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D003877:Dermatitis, Contact / Q000276:immunology / Q000473:pathology*; D004137:Dinitrochlorobenzene; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007124:Immunoenzyme Techniques; D007801:Langerhans Cells / Q000276:immunology / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009578:Nitrobenzenes; D010328:Patch Tests; D012867:Skin / Q000276:immunology / Q000473:pathology*; D013997:Time Factors
chemical_list: D000911:Antibodies, Monoclonal; D004137:Dinitrochlorobenzene; D009578:Nitrobenzenes