Neutral proteinases from human inflammatory cells. A critical review of their role in extracellular matrix degradation.
The cell biology and in vitro activity of neutral proteinases derived from inflammatory cells and the mechanisms by which these enzymes might injure connective tissue are outlined. Current work directed toward understanding local control of tissue degradation may lead to effective strategies for assessing and reducing connective tissue injury in human disease.
D000818:Animals; D003238:Connective Tissue / Q000378:metabolism / Q000473:pathology*; D005109:Extracellular Matrix / Q000378:metabolism / Q000473:pathology*; D005353:Fibronectins / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000201:enzymology* / Q000473:pathology; D008264:Macrophages / Q000201:enzymology / Q000378:metabolism; D051379:Mice; D009000:Monocytes / Q000201:enzymology / Q000378:metabolism; D009504:Neutrophils / Q000201:enzymology / Q000378:metabolism; D010196:Pancreatic Elastase / Q000502:physiology; D010447:Peptide Hydrolases / Q000502:physiology*; D011480:Protease Inhibitors / Q000097:blood / Q000378:metabolism
D005353:Fibronectins; D011480:Protease Inhibitors; D010447:Peptide Hydrolases; D010196:Pancreatic Elastase