Expression of H-Y antigen by female mice carrying Sxr.
The minor transplantation antigen H-Y can cause graft rejection and can stimulate the generation of H-2-restricted T cell responses. We have used both responses to type karyotypically abnormal mice for the presence of H-Y antigen, in order to investigate the role of H-Y in sex determination. The mice under scrutiny were Sxr5-carrying females derived by crossing females carrying the T(16;X)16H translocation with Sxr carrying males. These females were fully fertile and were H-Y positive. These results are consistent with the testis determining gene, Tdy, which may or may not be H-Y, having a threshold effect on testis differentiation during embryogenesis. They also show that the presence of H-Y in adult females does not impair reproduction.
D000818:Animals; D002999:Clone Cells / Q000276:immunology; D005260:Female; D005786:Gene Expression Regulation; D006084:Graft Rejection; D006183:H-2 Antigens / Q000235:genetics; D006182:H-Y Antigen / Q000032:analysis / Q000235:genetics* / Q000276:immunology; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains / Q000276:immunology; D012733:Sex Differentiation; D016038:Skin Transplantation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D006183:H-2 Antigens; D006182:H-Y Antigen