title: Systemic effects of biomaterials.
abstract: Evaluation of the host response to implanted biomaterials usually focuses on the implant site tissue response. This may lead to erroneous conclusions in the same way that examination of battles outside of their historic context does. A broader view discloses a variety of possible and actual systemic effects of carcinogenic, metabolic, immunological and bacteriological nature. Recognition of these effects in patients is hampered by a lack of epidemiological studies.
mesh_terms: D000818:Animals; D001424:Bacterial Infections / Q000382:microbiology; D001672:Biocompatible Materials / Q000009:adverse effects*; D002273:Carcinogens / Q000633:toxicity; D006801:Humans; D007109:Immunity / Q000187:drug effects; D008660:Metabolism / Q000187:drug effects; D008768:Methylmethacrylates / Q000633:toxicity; D009532:Nickel / Q000633:toxicity; D019736:Prostheses and Implants / Q000009:adverse effects
chemical_list: D001672:Biocompatible Materials; D002273:Carcinogens; D008768:Methylmethacrylates; D009532:Nickel