Localization of immunoreactive enkephalins in GABA synthesizing neurons of the rat neostriatum.
The localization of immunoreactive glutamic acid decarboxylase (GAD) and enkephalin-like immunoreactivity was examined in serial, 4-micron frozen sections of the caudate nucleus from rats pretreated with colchicine. Colocalization was found in numerous caudate neurons of medium size. Cell counts of corresponding labeled neurons in paired adjacent sections showed that GAD and enkephalin-like immunoreactivity coexist in about one half of the caudate cell populations containing each of these substances.
D000818:Animals; D002421:Caudate Nucleus / Q000378:metabolism* / Q000502:physiology; D004743:Enkephalin, Leucine / Q000378:metabolism; D004744:Enkephalin, Methionine / Q000378:metabolism; D004745:Enkephalins / Q000378:metabolism*; D005968:Glutamate Decarboxylase / Q000378:metabolism; D007124:Immunoenzyme Techniques; D009433:Neural Inhibition; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis*
D004745:Enkephalins; D005680:gamma-Aminobutyric Acid; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D005968:Glutamate Decarboxylase