Genetically engineered monoclonal antibody for E coli diarrhea in calves.
A genetically engineered monoclonal antibody, given PO to calves within 12 hours of birth, reduced the severity of diarrhea caused by enterotoxigenic K99 E coli. In challenge studies, dehydration and deaths were markedly reduced in treated calves vs untreated controls (29% vs 82%, 28% vs 82%). Use of the antibody in double-blind field trials on dairy calves in 9 herds in 5 states markedly reduced the severity of E coli diarrhea.
D000818:Animals; D000831:Animals, Newborn; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D000954:Antigens, Surface / Q000276:immunology; D001427:Bacterial Toxins; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D002986:Clinical Trials as Topic / Q000662:veterinary; D003967:Diarrhea / Q000517:prevention & control / Q000662:veterinary*; D004311:Double-Blind Method; D004926:Escherichia coli / Q000276:immunology*; D004927:Escherichia coli Infections / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D007116:Immunization, Passive / Q000662:veterinary*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D001427:Bacterial Toxins; C031429:K99 antigen