title: A comparison of three dosages of prostaglandin E2 pessaries for ripening the unfavourable cervix prior to induction of labor.
abstract: A study was planned to evaluate the effect of Prostaglandin E2 pessaries in three different dosages in ripening the unfavourable cervix prior to the induction of labor. A single dose of PGE2 as pessary in the three different dosages was administered into the posterior vaginal fornix to ripen an unfavourable cervix with a Bishop score less than or equal to 4 in 101 primigravid and 79 multigravid patients. The pessary containing 2 mgm was as effective as 3 mgm and 5 mgm PGE2 pessary in ripening the cervix, and the outcome of labor and fetal status were similar with the different dosages of PGE2. However, two multigravid patients who received 5 mg of PGEs pessary and one multigravid patient who received 3 mg of PGE2 pessary developed hypertonic uterine activity. None of the patients who received 2 mg PGE2 pessary developed any adverse effect on uterine activity.
mesh_terms: D000293:Adolescent; D000328:Adult; D001034:Apgar Score; D002584:Cervix Uteri / Q000187:drug effects*; D002986:Clinical Trials as Topic; D015232:Dinoprostone; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007751:Labor, Induced; D010298:Parity; D011247:Pregnancy; D011458:Prostaglandins E / Q000008:administration & dosage*; D014621:Vagina
chemical_list: D011458:Prostaglandins E; D015232:Dinoprostone