Differential susceptibility of rodent malaria parasites to nonspecific immunity.
Nonspecific immunity to rodent malaria parasites can be produced by immunising mice with heterologous parasites or pretreating them with BCG, Corynebacterium parvum or Brucella abortus. Nonspecific immunity is easily produced against Plasmodium vinckei but not P. berghei. This is due to the difference between the cells occupied by the parasites, young red blood cells in the case of P. berghei and mature red blood cells in the case of P. vinckei.
D000496:Alloxan / Q000494:pharmacology; D000818:Animals; D004198:Disease Susceptibility; D004912:Erythrocytes / Q000469:parasitology; D005260:Female; D007113:Immunity, Innate; D008288:Malaria / Q000276:immunology*; D051379:Mice / Q000469:parasitology*; D010962:Plasmodium berghei / Q000276:immunology; D013045:Species Specificity
D000496:Alloxan