title: Sarcoidosis--the beginning: historical highlights of personalities and their accomplishments during the early years.
abstract: Sarcoidosis, an affliction of mankind named only as recently as this century, was first described by Hutchinson in 1878, and noted in a second patient, one Mrs. Mortimer, in 1898. In 1889, Besnier described lupus pernio.Boeck obtained skin biopsies in 1899. Kreibich described punched-out bone lesions in 1904. Darier and Roussy described subcutaneous nodules in 1906, and Heerfordt described uveoparotid fever in 1909. Schaumann synthesized the many diverse syndromes of sarcoidosis into a single disease in a prizewinning essay in 1914. Kveim biopsied the sarcoid skin test-site and established a diagnostic test in 1941.Lofgren described the bilateral hilar lymphadenopathy-erythema nodosum syndrome in 1946. In 1954, Israel and Sones helped establish sarcoidosis as an immunologic disorder. In 1963 Cummings compiled a bibliography on sarcoidosis, and in 1966 Siltzbach conducted his renowned international Kveim test trial.At Howard University, Harden ignited an interest in sarcoidosis. In 1944 Johnson and Jason contributed to a description of cardiac involvement, while Cowan studied ocular involvement in sarcoidosis.
mesh_terms: D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D012507:Sarcoidosis / Q000266:history*; D012871:Skin Diseases / Q000266:history*