Treatment of non-specific vaginitis with a single dose of tinidazole.
In a double-blind, randomized trial twenty-six patients with non-specific vaginitis were treated with tinidazole/placebo (4 X 500 mg in one single dose). Thirteen patients received placebo, of which one was cured. Thirteen patients received tinidazole, of which six were cured. The nineteen non-responders received tinidazole (4 X 500 mg in one single dose), which resulted in the cure of eight patients (seven from the original placebo-group and one from the original tinidazole-group). Of the eleven patients not responding to tinidazole seven were successfully treated with metronidazole (250 mg, 4 times daily, for one week).
D000328:Adult; D002986:Clinical Trials as Topic; D004352:Drug Resistance, Microbial; D005260:Female; D005500:Follow-Up Studies; D006194:Gardnerella vaginalis / Q000187:drug effects; D006192:Haemophilus Infections / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D008875:Middle Aged; D009593:Nitroimidazoles / Q000008:administration & dosage*; D010919:Placebos; D012107:Research Design; D013997:Time Factors; D014011:Tinidazole / Q000008:administration & dosage*; D014627:Vaginitis / Q000188:drug therapy*
D009593:Nitroimidazoles; D010919:Placebos; D014011:Tinidazole; D008795:Metronidazole