Clinical trial of hyposensitisation in hay fever: two methods of relating symptom scores to daily pollen counts.
Two methods of relating daily pollen counts to patients' symptom scores in clinical trials of hyposensitisation in hay fever are described. The problems involved in comparing results from different centres and years of a trial are discussed with particular reference to symptoms which are not pollen related. The Normalised Regression method is a powerful technique, but often the Pollen Interval method is preferable on the grounds of simplicity of communication and calculation.
D002986:Clinical Trials as Topic; D003258:Consumer Behavior; D003888:Desensitization, Immunologic / Q000379:methods*; D006801:Humans; D007158:Immunologic Techniques; D007167:Immunotherapy; D010349:Patient Compliance; D011058:Pollen / Q000032:analysis*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology*; D013997:Time Factors