Effects of tendamistate on postprandial plasma glucose, free fatty acid and triglyceride levels.
A dose of 400 mg tendamistate or a placebo was given to 10 volunteers in order to investigate its effects on plasma glucose, free fatty acid and triglyceride levels after a porridge meal. Each subject participated in two phases, in each of which they ate porridge prepared from 100 g maize meal together with either placebo or tendamistate 400 mg. Serial blood specimens for plasma glucose determinations were taken up to 3 hours after the meal, and those for free fatty acid and triglyceride determinations up to 14 hours after the meal. Side-effects (flatulence and bulky stools) were not severe and were reported after both treatments. Tendamistate administration significantly attenuated postprandial glycaemia; it had no effect on postprandial triglyceride levels and was associated with a reduction in free fatty acid levels.
D001786:Blood Glucose / Q000032:analysis*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006801:Humans; D010455:Peptides / Q000494:pharmacology*; D013997:Time Factors; D014280:Triglycerides / Q000097:blood*; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D010455:Peptides; D014280:Triglycerides; D000516:alpha-Amylases; C030526:tendamistate