[Effect of gluco- and mineralocorticoids on the structure and function of the insular apparatus of the pancreas in representatives of different classes of vertebrates].
By means of histological, historadioautographical and biochemical methods the effect produced by disturbances in hormonal balance of the adrenal cortex (corticosteroids) on the islet apparatus of the pancreas in the lamprey (Lampetra fluviatilis), the frog (Rana temporaria), the tortoise (Testudo horsfieldi), the pigeon (Columbia livia), the white rat (Rattus rattus) has been studied during autumn-winter period. Chronic injections of hydrocortisone and desoxycorticosterone-acetate are used to change the hormonal balance in the adrenal cortex. In Cyclostomata, Amphibia and Reptilia gluco- and mineralocorticoids produce similar effects by increasing glycemia level. In birds and Mammalia glucocorticoids increase glycemia level, and mineralocorticoids do not change it. An increased glucose level in the organism of the representatives of various Mammalian classes after an excess injection of glucocorticoids is accompanied with a mainfested degranulation, hypertrophy of the Golgi complex, vacuolization of aldehydefuchsin-positive B-cell. Glucocorticoides increase the level of 35S-methyonine incorporation into B-cells of Langerhans islet in the representatives of all the vertebral classes studied. Mineralocorticoids act similarly as glucocorticoids stimulating protein metabolism only in Amphibia and birds. The level of immunoreactive insulin (IRI) in response to glucocorticoids injection increases in Amphibia and Mammalia and remains unchanged in Cyclostomata, Reptilia and birds. IRI remains unchanged after injection of mineralocorticoids in all representatives of Vertebrata, besides Cyclostomata in which IRI decreases.
D000818:Animals; D010856:Columbidae; D003900:Desoxycorticosterone / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D007798:Lampreys; D008715:Methionine / Q000378:metabolism; D008854:Microscopy, Electron; D011896:Rana temporaria; D051381:Rats; D013045:Species Specificity; D014426:Turtles
D007328:Insulin; D003900:Desoxycorticosterone; D008715:Methionine; D006854:Hydrocortisone
Vliianie gliuko- i mineralokortikoidov na strukturu i funktsiiu ostrovkovogo apparata podzheludochnoĭ zhelezy u predstaviteleĭ raznykh klassov pozvonochnykh zhivotnykh.