[Intragastric pH increase using antacids or secretin for stress ulcer prevention in surgical risk patients].
The efficacy of an antacid or synthetic secretion on elevations in intragastral pH above 4 was tested in a controlled prospective study. 21 surgical high risk patients received an antacid, and 17 secretin. Antacid prophylaxis resulted in a significantly higher intragastral pH than with secretin. This was especially true in patients with several risk factors. The percentage of secretin patients with a pH reduction below 4 was higher. An increase in dosage was necessary in 4 of the 17 patients receiving secretin and in none of those receiving antacids. One stress ulcer hemorrhage occurred during secretin infusion.
D000368:Aged; D000863:Antacids / Q000494:pharmacology / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005750:Gastric Juice / Q000032:analysis*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008875:Middle Aged; D010437:Peptic Ulcer / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies; D011897:Random Allocation; D012306:Risk; D012633:Secretin / Q000494:pharmacology / Q000627:therapeutic use*; D013312:Stress, Physiological; D013514:Surgical Procedures, Operative / Q000009:adverse effects*
D000863:Antacids; D012633:Secretin
Intragastrale pH-Anhebung mit Antacida oder Secretin als Stressulcus-Prophylaxe bei chirurgischen Risikopatienten.