title: Stimulation of renin release from rat kidney cortical slices by vitamin E-deficiency.
abstract: Effect of vitamin E-deficiency on renin release was examined with rat kidney cortical slices. Male Wistar rats were fed either a control or a vitamin E-deficient diet for 4 weeks. When kidney cortical slices were incubated in a Krebs-Ringers' bicarbonate solution (pH 7.4) at 37 degrees C, the rate of renin release into the incubation medium in vitamin E-deficient group was significantly higher than that in the control group. However, dietary supplementation of alpha-tocopheryl acetate (TOCA) or N,N'-diphenyl-p-phenylenediamine (DPPD) to the vitamin E-deficient rats for 5 d suppressed the stimulation of renin release from kidney cortical slices by vitamin E-deficiency. On the other hand, the release of protein, acid phosphatase and alkaline phosphatase during incubation of kidney cortical slices was not affected by vitamin E-deficiency or supplementations of TOCA and DPPD. These findings indicate that vitamin E-deficiency specifically stimulates renin release from kidney cortical slices and this effect is attenuated by the dietary supplementation of TOCA or DPPD.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D007672:Kidney Cortex / Q000201:enzymology*; D008297:Male; D010655:Phenylenediamines / Q000627:therapeutic use; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000378:metabolism*; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives / Q000627:therapeutic use; D014811:Vitamin E Deficiency / Q000188:drug therapy / Q000201:enzymology*; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
chemical_list: D010655:Phenylenediamines; D011506:Proteins; D014810:Vitamin E; C004845:N,N'-diphenyl-4-phenylenediamine; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D012083:Renin; D024502:alpha-Tocopherol; D024505:Tocopherols