title: Opposite effects of total lymphoid irradiation on T cell-dependent and T cell-independent antibody responses.
abstract: The effect of total lymphoid irradiation (TLI) on the primary antibody response to the dinitrophenylated heterologous protein, keyhole limpet hemocyanin (DNP-KLH), in complete Freund's adjuvant (CFA), and to the trinitrophenylated polysaccharide antigen, Brucella abortus (TNP-BA), was studied in BALB/c mice. The antibody response to both antigens was diminished in comparison with nonirradiated mice when antigens were injected within 3 days after TLI. When the mice were immunized 30 days after completion of TLI the antibody response to DNP-KLH in CFA was still diminished, but the antibody response to TNP-BA was enhanced 5- to 10-fold as compared with that of control animals. The opposite effect of TLI on the two antibody responses was also observed in a syngeneic primary adoptive transfer system.
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D000955:Antigens, T-Independent / Q000008:administration & dosage / Q000276:immunology; D002004:Brucella Vaccine / Q000276:immunology; D004136:Dinitrobenzenes / Q000276:immunology; D005260:Female; D006433:Hemocyanins; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007518:Isoantibodies / Q000096:biosynthesis*; D008221:Lymphoid Tissue / Q000528:radiation effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000276:immunology / Q000528:radiation effects*; D013997:Time Factors; D014301:Trinitrobenzenes / Q000276:immunology; D014916:Whole-Body Irradiation
chemical_list: D000941:Antigens; D000955:Antigens, T-Independent; D002004:Brucella Vaccine; D004136:Dinitrobenzenes; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007518:Isoantibodies; D014301:Trinitrobenzenes; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin