Effect of different prostaglandin analogues on gastric acid secretion and mucosal blood flow in the dog: action on stimulated and resting mucosa.
The effect of PG-E2, 16-16-DMPGE2, PG-F2 alpha and PG-I2 was investigated on histamine stimulated and resting canine gastric mucosa. PG-F2 alpha had no effect on mucosal circulation or acid secretion. PG-E2 and 16-16-DMPGE2 showed an increasing effect on blood flow of the resting mucosa. PG-E2, 16-16-DMPGE2 and PG-I2 decreased of acid secretion; the effect seemed to be due to a direct action on the parietal cells.
D015064:16,16-Dimethylprostaglandin E2 / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D015237:Dinoprost; D015232:Dinoprostone; D004285:Dogs; D011464:Epoprostenol / Q000494:pharmacology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology*; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D011465:Prostaglandins, Synthetic / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D013268:Stimulation, Chemical
D011458:Prostaglandins E; D011460:Prostaglandins F; D011465:Prostaglandins, Synthetic; D006632:Histamine; D015237:Dinoprost; D011464:Epoprostenol; D015232:Dinoprostone; D015064:16,16-Dimethylprostaglandin E2