Evaluation of radioprotectors by the Na+ influx study in RBC of lethally irradiated rats.
Sodium homeostasis in adult male albino Sprague Dawley rats has been examined 24 hours after exposure to 11 Gy whole-body gamma irradiation. Rate of influx of 22Na in red blood corpuscles (in vitro) of irradiated rats significantly increased and was modified by the administration of some radioprotective drugs prior to irradiation. Solcoseryl and AET (200 mg/kg) gave excellent protection and the combinations of 5-HTP with AET or MPG rendered better protection than when used alone.
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects / Q000528:radiation effects*; D004359:Drug Therapy, Combination; D004912:Erythrocytes / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D010042:Ouabain / Q000494:pharmacology; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000097:blood*; D014882:Water-Electrolyte Balance / Q000528:radiation effects; D014916:Whole-Body Irradiation
D011837:Radiation-Protective Agents; D010042:Ouabain; D012964:Sodium