title: Topical zinc oxide treatment improves arterial and venous leg ulcers.
abstract: We performed a randomized, double-blind study of the efficacy of locally applied zinc oxide on the healing of leg ulcers. Thirty-seven geriatric patients, nineteen with arterial and eighteen with venous leg ulcers, were treated either with a gauze compress medicated with zinc oxide (400 micrograms ZnO/cm2) or with an identical compress without zinc oxide. The treatment was assessed from ulcer size measurements and the presence or absence of granulation and ulcer debridement over a period of 8 weeks. The zinc-treated patients (83% success rate) responded significantly better (P less than 0.05) than the placebo-treated patients (42% success rate). The results suggest that healing of leg ulcers is improved after the addition of zinc oxide to the local regimen.
mesh_terms: D000287:Administration, Topical; D000368:Aged; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy*; D008297:Male; D011897:Random Allocation; D015032:Zinc / Q000627:therapeutic use*; D015034:Zinc Oxide / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D015032:Zinc; D015034:Zinc Oxide