Renal response of fowl to hypertonic saline infusion into the renal portal system.
The avian kidney has a dual blood supply: one arising from the renal arteries and the other from the renal portal system. In anesthetized pullets (Gallus gallus) two major shunt pathways bypassing the kidney were occluded to ensure the venous blood returning from the leg suffuses the peritubular sites before it enters the systemic circulation. Urine was collected from the ureteral orifices. When 5% NaCl (2.0 ml X kg-1 X h-1) was infused for 20 min into the renal portal system, urine flow and urinary NaCl concentrations and excretion rates increased immediately in the infused side. Infusion of 5% NaCl into the systemic circulation produced no natriuresis. Infusion of 10% NaCl (4.0 ml X kg-1 X h-1), into either the systemic or renal portal route, caused a prolonged antidiuresis. Plasma renin activity (PRA) decreased after portal infusion of 5% NaCl and after both portal and systemic infusion of 10% NaCl. These results suggest that 1) infusion of hypertonic saline into the renal portal system produces local renal effects and 2) increases in tubular or peritubular NaCl levels may suppress PRA.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002645:Chickens; D007444:Inulin / Q000378:metabolism; D007668:Kidney / Q000098:blood supply*; D011168:Portal System / Q000187:drug effects*; D012083:Renin / Q000097:blood; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D012965:Sodium Chloride / Q000494:pharmacology* / Q000652:urine
D012462:Saline Solution, Hypertonic; D012965:Sodium Chloride; D007444:Inulin; D012083:Renin