The enzymatic synthesis of lipid A: molecular structure and biologic function of monosaccharide precursors.
Certain Escherichia coli mutants, deficient in phosphatidylglycerol, accumulate novel, glucosamine-derived phospholipids that appear to be very early precursors of lipid A. The simplest of these, lipid X, is a derivative of glucosamine-1-phosphate substituted with beta-hydroxymyristoyl moieties at positions 2 and 3. The discovery of lipid X makes it possible to predict a biosynthetic pathway and a unified structure for lipid A. In addition, the minimal molecular requirements for the mitogenic and endotoxic properties of lipopolysaccharides can be elucidated with compounds of this kind.
D000818:Animals; D004187:Disaccharides / Q000378:metabolism; D004731:Endotoxins / Q000633:toxicity; D004926:Escherichia coli / Q000378:metabolism; D008050:Lipid A / Q000096:biosynthesis* / Q000633:toxicity; D051379:Mice; D008934:Mitogens / Q000494:pharmacology; D009005:Monosaccharides / Q000378:metabolism; D009154:Mutation; D010715:Phosphatidylglycerols / Q000096:biosynthesis; D013329:Structure-Activity Relationship; D013400:Sugar Acids / Q000096:biosynthesis
D004187:Disaccharides; D004731:Endotoxins; D008050:Lipid A; D008934:Mitogens; D009005:Monosaccharides; D010715:Phosphatidylglycerols; D013400:Sugar Acids; C002532:2-keto-3-deoxyoctonate