Pneumococcal polysaccharide capsular antigens in chronic secretory otitis media.
In a series of 163 ears with chronic, mucoid effusion, free or immune complex bound pneumococcal capsular polysaccharide antigens were demonstrated with Omniserum and counterimmunoelectrophoresis (CIEP) in 37 ears (23%). In crushed adenoid tissue this figure was 39% (42/107). Using type- or group-specific sera pneumococcus type 6 was found to be most frequent (56%) followed by type 19 (17%). A similar trend was also seen in adenoid suspensions. The results suggest that development of secretory otitis media is much more linked with the pneumococcal serotypes than has been thought hitherto, and that type 6 occurs significantly more often bound in immune complexes than any other subtype.
D000234:Adenoids / Q000276:immunology / Q000473:pathology; D000936:Antigen-Antibody Complex / Q000276:immunology; D001431:Bacteriological Techniques; D002908:Chronic Disease; D006801:Humans; D010033:Otitis Media / Q000276:immunology*; D010034:Otitis Media with Effusion / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology*
D000936:Antigen-Antibody Complex; D011135:Polysaccharides, Bacterial