title: Diabetic retinopathy I. The course of retinopathy in insulin-treated diabetics. A one year epidemiological cohort study of diabetes mellitus. The Island of Falster, Denmark.
abstract: The course of diabetic retinopathy was investigated in 215 out of 227 insulin-treated diabetics in a one year epidemiological cohort study. Twelve diabetics, all with an onset age greater than or equal to 30 years, could not be re-examined due to deaths in 11 diabetics and deny in 1 diabetic. At the one year follow-up no change (P greater than 0.10) occurred in the prevalence of background retinopathy (50.0% vs 51.6%) or of proliferative retinopathy (16.3% vs 18.6%). The one year incidence of newly developed background retinopathy was 3.7% and of deteriorated retinopathy 10.7%. Newly developed proliferative retinopathy was found in 2.3% of the diabetics after one year. Deterioration of pre-existing background retinopathy developed most frequently among diabetics with a diabetes duration above 10 years. Deterioration of both background retinopathy and proliferative retinopathy showed a sudden onset in some diabetics. Partial sight and legal blindness caused by diabetic retinopathy developed in 3.7% of the diabetics, respectively.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003718:Denmark; D003922:Diabetes Mellitus, Type 1 / Q000150:complications* / Q000188:drug therapy; D003930:Diabetic Retinopathy / Q000453:epidemiology* / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D014792:Visual Acuity
chemical_list: D007328:Insulin