Chloramphenicol acetyltransferase should not provide methanogens with resistance to chloramphenicol.
Growth of the four methanogens investigated was inhibited by chloramphenicol-3-acetate; therefore, introduction of chloramphenicol acetyltransferase-encoding genes should not confer chloramphenicol resistance on these methanogens. Reduction of the aryl nitro group of chloramphenicol produced a compound which did not inhibit the growth of these methanogens.
D000123:Acetyltransferases / Q000235:genetics*; D002701:Chloramphenicol / Q000031:analogs & derivatives / Q000633:toxicity*; D015500:Chloramphenicol O-Acetyltransferase; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects; D019605:Euryarchaeota / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D000432:Methanol / Q000378:metabolism; D013045:Species Specificity
C026822:chloramphenicol 3-acetate; D002701:Chloramphenicol; D000123:Acetyltransferases; D015500:Chloramphenicol O-Acetyltransferase; D000432:Methanol