title: Noninfected corneal ulceration.
abstract: The pathogenesis of noninfected corneal ulcers consistently relates to persistent or extensive epithelial defects, concomitant with stromal inflammatory cell infiltration and enzymatic degradation of collagen and ground substance. The therapeutic approaches to these disorders may be considered on three levels: (1) determination of etiology and institution of primary therapy; (2) promotion of epithelial healing; and (3) limitation of ulceration and support of repair. The latter two aspects feature pharmacological management and limited surgical modalities, particularly the use of tissue adhesive.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002387:Cataract Extraction / Q000009:adverse effects; D003228:Conjunctiva / Q000637:transplantation; D003315:Cornea / Q000601:surgery; D016039:Corneal Transplantation; D003320:Corneal Ulcer / Q000209:etiology / Q000601:surgery / Q000628:therapy*; D006801:Humans; D011183:Postoperative Complications; D014014:Tissue Adhesives / Q000008:administration & dosage
chemical_list: D000305:Adrenal Cortex Hormones; D000900:Anti-Bacterial Agents; D014014:Tissue Adhesives