Absence of mutagenicity of trioxane and dioxolane in Salmonella typhimurium.
The mutagenic activity of trioxane and dioxolane was investigated in 5 histidine-requiring strains of S. typhimurium: TA1535, TA1537, TA1538, TA98 and TA100 with and without activation by liver microsomes. They were not mutagenic under any of these conditions with any of the his- S. typhimurium tester strains (in the presence or absence of S9 mix from liver homogenate of rats induced with Aroclor 1254).
D000818:Animals; D001711:Biotransformation; D004148:Dioxolanes / Q000633:toxicity*; D004149:Dioxoles / Q000633:toxicity*; D006571:Heterocyclic Compounds / Q000633:toxicity*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects
D004148:Dioxolanes; D004149:Dioxoles; D006571:Heterocyclic Compounds; D009153:Mutagens; C011374:s-trioxane; C010962:formal glycol