2-DG-induced glucopenia does elicit feeding in rats with lesions of the zona incerta.
Rats with lesions of the rostral zona incerta (ZI) were maintained on either a palatable liquid diet or Purina Laboratory Chow and tested for their ability to respond to acute cellular glucoprivation. Food intake was measured at two-hour intervals during a six-hour feeding test following the administration of either 2-deoxy-D-glucose (2-DG) (200, 400 and 600 mg/kg) or insulin (4 U/rat). ZI-lesioned rats maintained on the liquid diet responded vigorously both to 2-DG and insulin-induced glucopenia. In contrast, ZI-lesioned animals consuming chow failed to augment feeding following 2-DG administration, although they did increase food intake as a function of insulin administration. These data suggest that dietary factors play an important role in the feeding responses of ZI-lesioned animals and must be considered when drawing conclusions about feeding behavior in brain-damaged animals.
D000818:Animals; D002241:Carbohydrates / Q000172:deficiency*; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D004027:Diencephalon / Q000502:physiology*; D004435:Eating / Q000187:drug effects*; D007328:Insulin / Q000494:pharmacology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002241:Carbohydrates; D003837:Deoxy Sugars; D007328:Insulin; D003847:Deoxyglucose