Therapeutic activity of ceftazidime and eleven other beta-lactam antibiotics against experimental Haemophilus influenzae, type b meningitis.
Twelve beta-lactams (11 cephalosporins and aztreonam) were compared in an infant rat model of Haemophilus influenzae, type b meningitis. Ceftazidime was the most effective compound tested and showed greater activity than cefuroxime, latamoxef (moxalactam) and cefotaxime--all of which have been used successfully in clinical haemophilus meningitis in children.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001398:Aztreonam; D002442:Ceftazidime; D002511:Cephalosporins / Q000627:therapeutic use*; D006193:Haemophilus influenzae; D008583:Meningitis, Haemophilus / Q000188:drug therapy*; D051381:Rats
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002442:Ceftazidime; D001398:Aztreonam