title: Comparison of ceftazidime, cefuroxime and methicillin in the treatment of Staphylococcus aureus endocarditis in rabbits.
abstract: Ceftazidime, cefuroxime and methicillin proved equally effective in the therapy of experimental Staphylococcus aureus endocarditis in rabbits with a dosing regimen of 40 mg/kg intramuscularly at 8-hourly intervals for three days. Treated animals all demonstrated a thousand to 10,000-fold reduction in the levels of bacteria in the vegetations compared with untreated controls. In-vitro sensitivities of the organism to the test antibiotics were not predictive of therapeutic efficacy in vivo.
mesh_terms: D000818:Animals; D002442:Ceftazidime / Q000097:blood / Q000627:therapeutic use*; D002444:Cefuroxime / Q000097:blood / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D004697:Endocarditis, Bacterial / Q000188:drug therapy*; D005260:Female; D008712:Methicillin / Q000097:blood / Q000627:therapeutic use*; D008826:Microbial Sensitivity Tests; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy*
chemical_list: D002511:Cephalosporins; D002442:Ceftazidime; D002444:Cefuroxime; D008712:Methicillin