title: The importance of prolactin for initiation of lactation in the pregnant ewe.
abstract: A single injection of ergocryptine (0.5 mg/kg liveweight) given to ewes 0.5-20 days prepartum or two injections (0.5 mg/kg liveweight per injection) given c. 30 and 10 days prepartum reduced concentrations of plasma prolactin to negligible (less than 5 ng/ml) values for 4 weeks after parturition, but did not affect concentrations of growth hormone and placental lactogen. Milking of treated ewes had no effect on concentrations of plasma prolactin during the first 4 weeks of lactation, but concentrations of growth hormone were increased during the 10-20 min period after milking. The half-life of prolactin in plasma was estimated as 21 min. In spite of the dramatic effect of ergocryptine on plasma prolactin all treated ewes secreted copious quantities of milk of normal composition. Mean daily yields of ewes treated with ergocryptine were not significantly different (P greater than 0.05) from those of untreated control ewes, but the mean +/- s.e.m. of total milk production over the first 3 weeks of lactation for ergocryptine-treated ewes was significantly lower (P less than 0.05) than that of control ewes (9.5 +/- 1.11 v. 14.1 +/- 1.20 kg milk). The results suggest that prolactin is not an essential component of the lactogenic and galactopoietic complexes of hormones in the ewe.
mesh_terms: D000818:Animals; D004873:Ergolines / Q000494:pharmacology; D005260:Female; D013006:Growth Hormone / Q000097:blood; D007774:Lactation / Q000187:drug effects; D010928:Placental Lactogen / Q000097:blood; D011247:Pregnancy; D011270:Pregnancy, Animal; D011388:Prolactin / Q000502:physiology*; D012756:Sheep / Q000502:physiology*
chemical_list: D004873:Ergolines; C100269:ergocryptine; D011388:Prolactin; D013006:Growth Hormone; D010928:Placental Lactogen