Comparison of the antidepressant action of tryptophan, tryptophan/5-hydroxytryptophan combination and nomifensine.
To check the hypothesis that combined treatment with tryptophan and 5-hydroxytryptophan is superior to the administration of tryptophan on its own we studied three groups of 8 patients. One group received tryptophan, the second a tryptophan/5-hydroxytryptophan combination and the third low-dose nomifensine as a control. The trial was performed in the double-blind mode, under strictly standardized conditions, with behavioural therapy and a structured daily routine. Complex covariance analysis of the Hamilton and AMP ratings revealed a superiority of the combination both over tryptophan on its own and over nomifensine.
D000328:Adult; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009627:Nomifensine / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D012701:Serotonin / Q000627:therapeutic use*; D014364:Tryptophan / Q000627:therapeutic use*
D007546:Isoquinolines; D009627:Nomifensine; D012701:Serotonin; D014364:Tryptophan