A microsurgical technique for simultaneous pancreas and renal transplantation in the rat.
A successful technique of simultaneous pancreatico-renal transplantation into the streptozotocin-induced diabetic rat is described employing a sutureless cuff technique for three of four vascular anastomoses. Reversal of the diabetic state was uniformly observed within 24 hours postoperatively and near-normal renal function was evidenced by 50 days postoperatively. The technique is reliable and reproducible and represents the first report of successful combined transplantation into the diabetic rat.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000601:surgery*; D003928:Diabetic Nephropathies / Q000601:surgery; D005260:Female; D016030:Kidney Transplantation; D008297:Male; D008866:Microsurgery / Q000379:methods*; D016035:Pancreas Transplantation; D051381:Rats