Adsorption of plasma from tumor-bearing hosts over protein A--containing nonviable Staphylococcus aureus Cowan I: possible mechanism of antitumor reactions.
Adsorption of autologous plasma over nonviable Staphylococcus aureus Cowan I (SAC) followed by reinfusion of the plasma causes regression of (a) chemically induced rat mammary adenocarcinomas (MA), and (b) canine transmissible venereal tumors (TVT) and spontaneously occurring dog tumors. Animal data are more impressive than that from trials in humans. Nine of 41 patients receiving perfusions of adsorbed plasma showed some partial objective response. Eight of these nine patients received multiple perfusions over a period of time. Twenty-one of 41 patients showed subjective responses. Adsorption of autologous plasma over non-protein A--containing S. aureus Wood 46 caused regression of MA. Adsorption of normal rat plasma with SAC, and infusion of this adsorbed plasma into mammary tumor--bearing rats, caused regression of MA. Intravenous infusion of purified protein A alone caused regression of both rat MA and canine TVT. Superimposed on this observation is the finding that, during plasma adsorption, bacterial moieties leach from SAC. It is possible that the immunostimulation observed in plasma-perfused hosts is due to the removal of plasma blocking agents on one hand, and introduction of the bacterial agents on the other.
D000230:Adenocarcinoma / Q000628:therapy*; D000328:Adult; D000368:Aged; D000818:Animals; D004285:Dogs; D005260:Female; D006801:Humans; D007163:Immunosorbent Techniques; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000628:therapy*; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy*; D051381:Rats; D013205:Staphylococcal Protein A / Q000627:therapeutic use*; D013211:Staphylococcus aureus / Q000276:immunology*; D014685:Venereal Tumors, Veterinary / Q000628:therapy*
D013205:Staphylococcal Protein A