Reversible tubular lesion in pregnancy-induced hypertension detected by urinary beta 2-microglobulin.
Serum and urine beta 2-microglobulin concentrations were measured in 17 primigravidas with mild pregnancy-induced hypertension and nine normotensive control patients matched for gestational age. Serum beta 2-microglobulin and creatinine clearance values were not different between the two groups but urinary excretion of beta 2-microglobulin was three times higher in the hypertensive patients. This difference disappeared within seven days of delivery. These results indicate that a reversible renal tubular lesion occurs in pregnancy-induced hypertension even in the absence of detectable proteinuria.
D001724:Birth Weight; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006977:Hypertension, Renal / Q000175:diagnosis* / Q000652:urine; D007231:Infant, Newborn; D007684:Kidney Tubules; D049590:Postpartum Period; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000175:diagnosis* / Q000652:urine; D001613:beta 2-Microglobulin / Q000652:urine*
D001613:beta 2-Microglobulin