Acute effects of ultraviolet light B on morphology and epidermal cell kinetics in human skin transplanted to nude mice.
Grafts of human skin on nude mice were irradiated with varying doses of ultraviolet light B and at various intervals were subjected to histological examination and determination of the epidermal 3H-thymidine labelling index. The studies showed that the human skin in the foreign milieu of the nude mouse retained its ability to respond to phototoxic damage. The findings suggest that the nude mouse/human skin model could be a valuable tool in human photodermatological research.
D000368:Aged; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D011832:Radiation Injuries / Q000473:pathology; D012867:Skin / Q000473:pathology / Q000528:radiation effects*; D012871:Skin Diseases / Q000209:etiology / Q000473:pathology; D016038:Skin Transplantation; D014183:Transplantation, Heterologous; D014466:Ultraviolet Rays