Major-histocompatibility-complex-restricted male skin graft rejection responses in rats.
Normal DA (RT1a) female rats rejected male skin isografts when preimmunized with RT1-compatible DA, or ACI (RT1a) male bone marrow cells (BMC), but failed to reject them when preimmunized with RT1-incompatible PvG/c (RT1c), F344 (RT1lvl), or BN (RT1n) male BMC--as well as when they were untreated. DA female rats rendered neonatally tolerant to RT1-incompatible PvG/c female tissues failed to reject, not only DA, but also PvG/c male skin grafts when preimmunized with PvG/c male BMC. DA female rats tolerant of PvG/c female tissues that had rejected DA male skin grafts following immunization with DA male BMC failed to reject PvG/c male skin grafts. These results indicate that in rats, unlike mice, male skin graft rejection responses are MHC-restricted, at least in the DA strain.
D000818:Animals; D016026:Bone Marrow Transplantation; D005260:Female; D006084:Graft Rejection; D006649:Histocompatibility Antigens / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology*; D007114:Immunization; D008297:Male; D051381:Rats; D011912:Rats, Inbred ACI; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344; D012727:Sex Characteristics; D016038:Skin Transplantation; D014185:Transplantation, Isogeneic
D006649:Histocompatibility Antigens; C038353:histocompatibility antigens RT, rat