Modulation by prostaglandin D2 of glucagon and insulin secretion in the perfused rat pancreas.
Effects of prostaglandin (PG) D2 on insulin and glucagon secretion from perfused rat pancreas were examined. In the presence of 2.8 mM glucose, only glucagon release was strongly stimulated by 14 microM of PGD2. When the glucose concentration was elevated to 11.2 mM, insulin release was accelerated by 14 microM of PGD2 but there was no effect upon glucagon release. Both glucagon and insulin releases induced by 19 mM arginine with PGD2 were not different from those without PGD2 in the presence of 2.8 mM glucose. But in the presence of 11.2 mM glucose, glucagon release induced by 19 mM arginine was augmented by 14 microM PGD2. Since the distribution of PGD2 has been reported to be in neuroendocrine organs, these results suggest that PGD2 is a possible candidate as a modulator in the neural control of endocrine pancreas.
D000818:Animals; D001120:Arginine / Q000494:pharmacology; D005934:Glucagon / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010477:Perfusion; D015230:Prostaglandin D2; D011457:Prostaglandins D / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D011457:Prostaglandins D; D005934:Glucagon; D001120:Arginine; D005947:Glucose; D015230:Prostaglandin D2