title: Urinary phenethylamine response to d-amphetamine in 12 boys with attention deficit disorder.
abstract: Urinary phenethylamine (PEA), an endogenous amine similar to amphetamine in both molecular structure and pharmacological properties, was studied in 12 boys with attention deficit disorder with hyperactivity. d-Amphetamine and placebo were given for 14 days each in a counterbalanced crossover design; double-blind teacher behavior ratings and motor activity measurements were also obtained. Excretion of PEA, phenylacetic acid, creatinine, and d-amphetamine were measured. PEA was significantly increased and phenylacetic acid was unchanged after d-amphetamine administration, and change in PEA excretion correlated significantly with d-amphetamine excretion. There was no significant relationship between either clinical response to drug and change in PEA or phenylacetic acid excretion.
mesh_terms: D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy* / Q000523:psychology / Q000652:urine; D002648:Child; D002986:Clinical Trials as Topic; D003404:Creatinine / Q000652:urine; D003913:Dextroamphetamine / Q000494:pharmacology / Q000627:therapeutic use* / Q000652:urine; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D009043:Motor Activity; D010627:Phenethylamines / Q000652:urine*; D010648:Phenylacetates / Q000652:urine; D010919:Placebos
chemical_list: D010627:Phenethylamines; D010648:Phenylacetates; D010919:Placebos; D003404:Creatinine; D003913:Dextroamphetamine