Glucose homeostasis in fasted neonatal rats treated with high doses of L-thyroxine.
A neo-T4 syndrome was induced by subcutaneous administration of high doses of L-thyroxine (T4) to neonatal rats. These doses produced important alterations in carbohydrate metabolism: hypoglycemia, hypoinsulinemia and increased levels of blood lactate, pyruvate and ketone bodies. T4-treated and control rats were subjected to fasting. In contrast to controls where glycemia decreased to 60% of basal values, in 11-day-old neo-T4 rats blood glucose levels decreased to only 90% of basal values. These different adaptations to fasting area discussed with regard to endocrine equilibrium in neo-T4 rats.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003345:Corticosterone / Q000097:blood; D005215:Fasting; D006706:Homeostasis; D007328:Insulin / Q000097:blood; D007657:Ketone Bodies / Q000097:blood; D007773:Lactates / Q000097:blood; D011773:Pyruvates / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013974:Thyroxine / Q000097:blood / Q000494:pharmacology*; D014284:Triiodothyronine / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D007657:Ketone Bodies; D007773:Lactates; D011773:Pyruvates; D014284:Triiodothyronine; D013974:Thyroxine; D003345:Corticosterone