title: [Generalized Mibelli's porokeratosis in transformation to spinocellular carcinoma. Clinical, histologic and ultrastructural study. Favorable response to RO-109359].
abstract: Two cases of Disseminated Poroqueratosis of Mibelli with squamous cell carcinomata development of many lesions are reported. Histopathological findings showed us the typical structure of the cornoid limella. Ultrastructural features are described with increased number of Langerhans" cells. Treatment in both cases was RO-109359. Squamous cell carcinomata were treated by surgical excision.
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic / Q000473:pathology* / Q000648:ultrastructure; D005050:Etretinate / Q000627:therapeutic use; D006801:Humans; D007642:Keratosis / Q000188:drug therapy / Q000473:pathology*; D007801:Langerhans Cells / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology* / Q000648:ultrastructure
chemical_list: D005050:Etretinate
vernacular_title: Poroqueratosis de Mibelli generalizada en transformación a carcinoma espinocelular. Estudio clínico, histológico y ultraestructural. Respuesta favorable a RO-109359.