Anti-intermediate filament antibody in mice infected with Plasmodium berghei.
Fifteen mice (CBA) were infected with lethal Plasmodium berghei and the development of anti-intermediate filament antibody (anti-IF) studied. Sera from all the infected animals reacted with the cytoplasmic network of intermediate filaments (IF) in the human epidermal laryngeal carcinoma (HEp2) cell line, as demonstrated by indirect immunofluorescence. Sera from 5 control animals injected with 10(4) unparasitized red cells showed no anti-IF reactivity. Anti-IF of IgM class was first detectable at day 11 in infected animals. Later, IgG as well and IgM anti-IF was found. A steady increase in anti-IF titre was observed during infection and a relationship between anti-IF titre and parasitaemia rate was noted.
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D003599:Cytoskeleton / Q000276:immunology*; D005260:Female; D008288:Malaria / Q000276:immunology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010962:Plasmodium berghei; D013997:Time Factors
D001323:Autoantibodies