Direct measurement of hepatitis B viral antibody and antigen markers in gingival crevicular fluid.
Radioimmunoassay analyses of serum are widely performed to monitor the incidence of hepatitis B virus infection. As an alternative to serum analyses, the authors have explored the feasibility of using gingival crevicular fluid for the detection and quantitation of hepatitis B viral immunologic markers. The results of the study demonstrate that the hepatitis B surface antigen can be easily quantified in gingival fluid. Confirmation of the presence of the hepatitis B e antigen can also be made, but this is more difficult because of the small amounts of gingival fluid currently being assayed. Antibody to the hepatitis B surface antigen can be quantitated in high-titered persons.
D000914:Antibodies, Viral / Q000032:analysis*; D000956:Antigens, Viral / Q000032:analysis*; D001769:Blood; D002353:Carrier State; D005883:Gingival Crevicular Fluid / Q000276:immunology*; D005891:Gingivitis / Q000276:immunology*; D006509:Hepatitis B / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D011863:Radioimmunoassay
D000914:Antibodies, Viral; D000956:Antigens, Viral