title: [Determination of cerebral blood flow using non-diffusible tracers].
abstract: A program for the evaluation of cerebral blood flow based on the analysis of the time activity curves is presented. The method is based on the Meier and Zierler formula, applying the partition coefficents suggested by Lassen et al. for the corrections deriving from the use of non-diffusible indicators (99Tcm-DTPA). Particular attention is given to the smoothing of the time-activity curve (using Legendre's polynomials) and to the correction function for reflux. The computation procedures and their validity is discussed.
mesh_terms: D001783:Blood Flow Velocity; D002533:Cerebral Angiography / Q000379:methods*; D002560:Cerebrovascular Circulation; D006801:Humans; D008433:Mathematics; D004369:Pentetic Acid; D013667:Technetium; D016284:Technetium Tc 99m Pentetate; D014057:Tomography, X-Ray Computed / Q000379:methods
chemical_list: D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate
vernacular_title: Determinazione del flusso ematico cerebrale con traccianti non diffusibili.