Monoclonal antibodies demonstrate similarity of surface antigens on different clones of Schistosoma mansoni schistosomula.
Previous work has demonstrated wide variation in the susceptibility of different clones of Schistosoma mansoni to resistance in mice induced by a small schistosome infection. Eight monoclonal antibodies directed against individual surface antigens of juvenile schistosomes (schistosomula) were used to determine the distribution of these antigens among clones of schistosomula. All eight antigens were detected on the surface membranes of the 32 clones of schistosomula tested. This result implies that polymorphism of schistosomula surface antigens is very unlikely to be the cause of the variation in susceptibility of different clones to resistance in mice. Absence of heterogeneity among surface antigens of schistosomula may facilitate experimental vaccination aimed against these putative target antigens.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000032:analysis*; D002999:Clone Cells / Q000276:immunology; D005455:Fluorescent Antibody Technique; D008297:Male; D051379:Mice; D012550:Schistosoma mansoni / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface