[Effect of amphotericin B on phagocytosis and intracellular killing of E. coli by rat liver perfused in vitro: preliminary results].
Using isolated and perfused rat livers we found an inhibitory effect on intracellular killing of hepatic macrophages versus E. coli, in presence of therapeutic levels of amphotericin B (5 micrograms/ml). Since an interference of this antibiotic with phagocytic functions of human neutrophils has also been reported, we suggest that amphotericin B may exert a toxic effect on intraphagocytic microbicidal function, possibly by an interaction with membrane sterols.
D000666:Amphotericin B / Q000494:pharmacology*; D000818:Animals; D004926:Escherichia coli / Q000276:immunology*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000276:immunology*; D008297:Male; D010477:Perfusion; D010587:Phagocytosis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D000666:Amphotericin B
Effetto dell'anfotericina B sulla fagocitosi ed uccisione intracellulare di E coli da parte del fegato di ratto perfuso in vitro: risultati preliminari.