title: Bone marrow transplantation. Problems and prospects.
abstract: Over the last 15 years, human bone marrow transplantation has evolved from experimental therapy of last resort for patients with end-stage leukemia and marrow aplasia. The increasing success and use of marrow transplants has stemmed from important advances made in (1) the understanding and definition of the major histocompatibility complex in man, (2) the development of safe yet efficacious immunosuppressive and myeloablative preconditioning regimens, and (3) the development of techniques of intensive supportive care for these patients during their intra- and post-transplant course.
mesh_terms: D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy; D000818:Animals; D016026:Bone Marrow Transplantation; D002648:Child; D003365:Costs and Cost Analysis; D006084:Graft Rejection; D006086:Graft vs Host Disease / Q000209:etiology; D006801:Humans; D007239:Infections / Q000209:etiology; D007945:Leukemia, Lymphoid / Q000628:therapy; D007951:Leukemia, Myeloid / Q000628:therapy; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D011379:Prognosis; D014019:Tissue Donors; D014180:Transplantation / Q000191:economics / Q000523:psychology; D014181:Transplantation Immunology