[Autoradiographic study of the renewal rate of neutrophils and thrombocytes in summer and winter frogs].
In early August frogs were injected with 3H-thymidine and observed during 10 months under conditions close to natural. Individual changes of neutrophil and thrombocyte contents in the blood, those of the number of labeled cells among them, and the density of labeling were studied. The life span of neutrophils in the active frogs was found as long as 2-3 weeks, while that of thrombocytes lasted for several months. In September the hibernating cell populations are formed and cell proliferation ceases. This process is suggested to be regulated by some complex centralized mechanisms rather than by a direct action of temperature. The size of circulating populations of both the cell types decreases during hibernation, part of the cells is deposited outside of circulation. The life span of cells rises considerably, their renewal begins only in spring. The ability of cells of the neutrophilic lineage to proliferate is preserved at low temperatures and is realized in pathological conditions. The similarities in seasonal adaptations are stated between amphibians and hibernating mammals at the level of cellular populations.
D000818:Animals; D001345:Autoradiography; D001772:Blood Cell Count; D001792:Blood Platelets / Q000166:cytology*; D002470:Cell Survival; D006410:Hematopoiesis; D007700:Kinetics; D009504:Neutrophils / Q000166:cytology*; D011896:Rana temporaria; D012621:Seasons; D013997:Time Factors
Avtoradiograficheskoe izuchenie skorosti obnovleniia neĭtrofilov i trombotsitov u letnykh i zimnikh liagushek.