Synthesis and biological activity of some di(nitrothienyl)- and di(acetylaminothienyl)sulfones.
Some new di(nitrothienyl)- and di(acetylaminothienyl)sulfones were synthesized. Compounds (I)-(VI) were active against several Gram-positive bacteria, in vitro. Di(5-acetylamino-2-thienyl)sulfone (VII) showed a mild antimalarial activity against a drug-sensitive strain of P. berghei in mice.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D000962:Antimalarials / Q000138:chemical synthesis* / Q000627:therapeutic use; D001419:Bacteria / Q000187:drug effects; D008288:Malaria / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D010962:Plasmodium berghei / Q000187:drug effects; D013450:Sulfones / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000962:Antimalarials; D013450:Sulfones