[Treatment of infection stones. I. Dissolution of experimental infection stones in rats].
The in vivo solubility of struvite stones experimentally induced in rats was investigated. The struvite stones implanted into bladders of normal rats were reduced in weight; and, they were dissolved by oral administration of ammonium chloride. Cefmetazone cured pyelonephritis and dissolved the bladder stones when it was administered to rats with urinary tract infection caused by Proteus mirabilis. Normalization of urine by antibiotics and acidifying agents may dissolve struvite stones, and help treat infection stones.
D000643:Ammonium Chloride / Q000627:therapeutic use*; D000818:Animals; D015311:Cefmetazole; D002513:Cephamycins / Q000627:therapeutic use*; D004195:Disease Models, Animal; D066298:In Vitro Techniques; D008274:Magnesium; D017616:Magnesium Compounds; D010710:Phosphates; D011512:Proteus Infections / Q000150:complications / Q000188:drug therapy; D011513:Proteus mirabilis; D051381:Rats; D000069877:Struvite; D001744:Urinary Bladder Calculi / Q000188:drug therapy* / Q000209:etiology; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy*
D002513:Cephamycins; D017616:Magnesium Compounds; D010710:Phosphates; D000643:Ammonium Chloride; D015311:Cefmetazole; D000069877:Struvite; D008274:Magnesium