title: Health implications of 2,3,7,8-tetrachlorodibenzodioxin (TCDD) contamination of residential soil.
abstract: Extrapolations from animal toxicity experiments (including carcinogenicity and reproductive effects) to possible human heath effects can be used to estimate a reasonable level of risk for 2,3,7,8-tetrachlorodibenzodioxin (2,3,7,8-TCDD). Extrapolations are derived from: (1) review of published studies, (2) a complex set of assumptions related to human exposure to contaminated soil, and (3) estimates of (a) a dose response curve, (b) appropriate margins of safety, and/or (c) applicable mechanisms of action. One ppb of 2,3,7,8-TCDD in soil is a reasonable level at which to begin consideration of action to limit human exposure for contaminated soil.
mesh_terms: D000818:Animals; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced; D003043:Cocarcinogenesis; D004147:Dioxins / Q000009:adverse effects*; D004781:Environmental Exposure; D004812:Epidemiologic Methods; D005260:Female; D006798:Housing; D006801:Humans; D007109:Immunity / Q000187:drug effects; D007408:Intestinal Absorption; D007700:Kinetics; D008433:Mathematics; D009153:Mutagens; D000072317:Polychlorinated Dibenzodioxins / Q000009:adverse effects* / Q000378:metabolism / Q000633:toxicity; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects; D012306:Risk; D012989:Soil Pollutants / Q000009:adverse effects*; D013723:Teratogens; D014018:Tissue Distribution
chemical_list: D002273:Carcinogens; D004147:Dioxins; D009153:Mutagens; D000072317:Polychlorinated Dibenzodioxins; D012989:Soil Pollutants; D013723:Teratogens