Systemic prophylactic antibiotics in elective biliary surgery.
We tested the effectiveness of prophylactic antibiotics in elective cholecystectomy in 105 patients in a single-blind, controlled randomized trial. Fifty-six patients received prophylactic antibiotics and 49 patients entered the control group. Of the patients who received prophylactic antibiotics, 3.6% had wound infections, v24.5% in the control group. The rate of wound infection in patients with positive bile cultures, diabetes, appendectomies, and choledochotomies was 24.4%, v 3.4% in the group who had cholecystectomies only, with negative bile cultures and no diabetes. We concluded that prophylactic antibiotics are effective in patients with high-risk factors such as diabetes mellitus, exploration of the choledochus, and appendectomy, and in patients with positive bile cultures.
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001062:Appendectomy / Q000009:adverse effects; D002763:Cholecystectomy / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D003135:Common Bile Duct / Q000601:surgery; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D007557:Israel; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011300:Preoperative Care; D011897:Random Allocation; D012306:Risk; D013530:Surgical Wound Infection / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*
D000900:Anti-Bacterial Agents