Blood glucose and serum C-peptide after a single chlorpropamide dose.
A single chlorpropamide dose, when compared to placebo, reduced blood glucose in volunteers during fasting and glucagon stimulation without increase in pancreatic beta cell secretion. The finding suggests that extrapancreatic mechanisms may play a substantial role in the chlorpropamide action also after a single drug dose.
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D002096:C-Peptide / Q000097:blood*; D002747:Chlorpropamide / Q000494:pharmacology*; D005260:Female; D005934:Glucagon / Q000097:blood; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D008297:Male; D013453:Sulfonylurea Compounds / Q000494:pharmacology
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin; D013453:Sulfonylurea Compounds; D005934:Glucagon; D002747:Chlorpropamide