Mechanism of immunosuppression in leprosy--macrophage membrane alterations.
L-Lysate induced macrophage membrane alteration was studied using 3 membrane markers: (i) Fc receptor, (ii) Concanavalin A (Con A) receptor, and (iii) M. leprae adherence to macrophage membrane. The data indicate that L-lysate induces membrane perturbation of normal macrophages. The alteration can be reversed with trypsin and colchicine. Membrane alteration observed may lead to defective macrophage participation in a cell-mediated immune reaction.
D002462:Cell Membrane / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D007918:Leprosy / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D009166:Mycobacterium leprae / Q000276:immunology; D011952:Receptors, Concanavalin A; D011961:Receptors, Fc
D011952:Receptors, Concanavalin A; D011961:Receptors, Fc