title: The effect of drugs on serum histidine levels in rheumatoid arthritis.
abstract: Groups of 15 patients with active rheumatoid arthritis were treated for 24 weeks with zinc sulphate, trien, captopril, clozic in two doses or a combination of D-penicillamine and hydroxychloroquine. Serum histidine levels were monitored along with measures of disease activity including C-reactive protein, plasma viscosity, articular index, grip strength and early morning stiffness. Zinc sulphate and trien were found to be ineffective while the other drugs all showed evidence of second-line action. Serum histidine was found to improve during successful therapy. The possible cause of low serum histidine and its response to therapy is discussed.
mesh_terms: D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy*; D002216:Captopril / Q000627:therapeutic use; D002994:Clofibrate / Q000031:analogs & derivatives / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D006639:Histidine / Q000097:blood*; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000627:therapeutic use; D013431:Sulfates / Q000627:therapeutic use; D014266:Trientine / Q000627:therapeutic use; D015032:Zinc / Q000627:therapeutic use; D019287:Zinc Sulfate
chemical_list: D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D013431:Sulfates; D006639:Histidine; D006886:Hydroxychloroquine; D019287:Zinc Sulfate; D002216:Captopril; D010396:Penicillamine; D002994:Clofibrate; D015032:Zinc; D014266:Trientine; C018431:clobuzarit