Decrease in insulin secretion related to hypocalcemia induced by a high dose of zinc in rats.
A single oral administration of zinc (Zn), sufficient to induce hypocalcemia, caused a decrease in glucose tolerance in fasted rats. This decrease resulted from reduction of insulin secretion. The restoration of Zn-induced hypocalcemia completely prevented the decrease in glucose tolerance and insulin secretion. These results suggest that the effect of Zn administration on insulin secretion in rats is a consequence of hypocalcemia.
D000284:Administration, Oral; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology; D005951:Glucose Tolerance Test; D006996:Hypocalcemia / Q000097:blood*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000008:administration & dosage / Q000633:toxicity*
D007328:Insulin; D001285:Atropine; D015032:Zinc; D002118:Calcium