title: Prostaglandins, related compounds, and the perinatal pulmonary circulation.
abstract: It is clear that prostaglandins and related compounds are important in the physiology and pathophysiology of the perinatal pulmonary circulation. This article focuses on what is known about prostaglandin-related compounds (PRC) in the pulmonary circulation of the developing and newly born mammal. Also included is a discussion of the effects of PRC on the ductus arteriosus and on the systemic circulation.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001095:Arachidonic Acids / Q000378:metabolism / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D011464:Epoprostenol / Q000494:pharmacology; D005260:Female; D005333:Fetus / Q000502:physiology*; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids / Q000494:pharmacology; D006976:Hypertension, Pulmonary / Q000503:physiopathology; D007231:Infant, Newborn; D008168:Lung / Q000098:blood supply; D010547:Persistent Fetal Circulation Syndrome / Q000503:physiopathology; D011247:Pregnancy; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D015230:Prostaglandin D2; D011453:Prostaglandins / Q000378:metabolism / Q000502:physiology*; D011457:Prostaglandins D / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D011652:Pulmonary Circulation / Q000187:drug effects; D013189:SRS-A / Q000494:pharmacology / Q000502:physiology; D012756:Sheep; D013931:Thromboxanes / Q000502:physiology; D014655:Vascular Resistance; D014661:Vasoconstriction
chemical_list: D001095:Arachidonic Acids; D006893:Hydroxyeicosatetraenoic Acids; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D011457:Prostaglandins D; D011458:Prostaglandins E; D011460:Prostaglandins F; D013189:SRS-A; D013931:Thromboxanes; D011464:Epoprostenol; D015230:Prostaglandin D2