title: Kinetic studies on the inhibition of Proteus vulgaris beta-lactamase by imipenem.
abstract: Imipenem was found to inhibit Proteus vulgaris beta-lactamase in a progressive manner. Kinetic experiments confirmed that the inactivated enzyme was not completely recovered after intact imipenem had been exhausted.
mesh_terms: D015378:Imipenem; D007700:Kinetics; D011514:Proteus vulgaris / Q000201:enzymology*; D013845:Thienamycins / Q000494:pharmacology*; D065093:beta-Lactamase Inhibitors
chemical_list: D013845:Thienamycins; D065093:beta-Lactamase Inhibitors; D015378:Imipenem