title: A model for the germ tube formation and mycelial growth form of Candida albicans.
abstract: A model based on morphological and ultrastructural evidence is presented which illustrates a novel and hitherto undescribed pattern of germ tube formation and hyphal growth in early and mature colonies of Candida albicans. Accordingly, most of the cytoplasm within the parent yeast cell migrates into and forward with the extending germ tubes and leaves behind an extensively vacuolated yeast cell. Growing hyphae similarly are subtended by migrating "slugs' of protoplasm and leave behind vacuolated intercalary compartments. The vacuolated cell compartments apparently must first regenerate their protoplasmic contents before producing branches or secondary germ tubes. This model is used to explain certain unusual features of the growth kinetics of the filamentous form of this organism.
mesh_terms: D002176:Candida albicans / Q000254:growth & development* / Q000502:physiology / Q000648:ultrastructure; D007700:Kinetics; D008954:Models, Biological; D013172:Spores, Fungal / Q000502:physiology