Morphologic and cytochemical study of L929 cell variants with different metastasizing ability in C3HA/Hab mice.
A morphologic (phase-contrast, TEM and SEM) and cytochemical study was performed on L929 cell variants that show different malignant behavior and lung colonization ability in C3HA/Hab mice. The paper presents and discusses the correlation between enhanced lung colonization ability and the expression in culture of rounded, risen, less attached morphologies. Also, a diminution in the activity of mitochondrial enzymes and number of these cell organelles was found for the cell variant selected for enhanced lung colonization ability.
D000818:Animals; D002460:Cell Line; D005353:Fibronectins / Q000032:analysis; D006651:Histocytochemistry; D007739:L Cells / Q000648:ultrastructure*; D051379:Mice; D008809:Mice, Inbred C3H; D008855:Microscopy, Electron, Scanning; D008858:Microscopy, Phase-Contrast; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure
D005353:Fibronectins