Loss of HLA-DR expression by human epidermal cells after growth in culture.
These studies present evidence that when human epidermal cells are grown in culture they lose both the ability to stimulate the proliferation of allogeneic T lymphocytes in vitro and their expression of HLA-DR antigens. Our results also show that epidermal cells incubated with anti-HLA-DR serum lose their ability to stimulate the proliferation to allogeneic T lymphocytes in a mixed skin cell-lymphocyte reaction.
D015214:Antigens, Differentiation, Myelomonocytic; D000954:Antigens, Surface / Q000032:analysis; D002478:Cells, Cultured; D004817:Epidermis / Q000648:ultrastructure; D005455:Fluorescent Antibody Technique; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007700:Kinetics; D008854:Microscopy, Electron; D012867:Skin / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
D015214:Antigens, Differentiation, Myelomonocytic; D000954:Antigens, Surface; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; C041878:Mac-120 antigen, human