Neoplastic cells containing lysozyme in gastric carcinomas.
A case of gastric carcinoma mostly composed of cells with histological, immunohistochemical and ultrastructural features of Paneth cells prompted a comparative investigation of the occurrence of similar cells in gastric, colorectal and mammary carcinomas. Cells containing lysozyme were demonstrated by the immunoperoxidase-PAP technique in 34.9% of 83 gastric carcinomas. They were found in 38% of intestinal-type and in 30% of diffuse-type tumours. Paneth-type granules were demonstrated ultrastructurally in 4 of 7 carcinomas in which lysozyme had been demonstrated immunohistochemically. No lysozyme was demonstrated in a series of 30 breast carcinomas and in only 1 of 27 cases of colorectal neoplasm. The possibility of using lysozyme as a marker for some carcinomas of gastric origin is considered.
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008207:Lymphatic Metastasis; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009113:Muramidase / Q000032:analysis*; D013274:Stomach Neoplasms / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure
D009113:Muramidase