title: Combined effect of cigarette smoking and allergic rhinitis on airway responsiveness to inhaled methacholine.
abstract: A group of healthy nonatopic subjects was compared with a group of atopic subjects with allergic rhinitis who were otherwise healthy. They were matched for sex, age, and smoking habits; 15 pairs were nonsmokers and 11 pairs were smokers. Threshold of airway response to inhaled methacholine based on partial flow-volume curves was not significantly different between nonatopic nonsmokers and nonsmokers with allergic rhinitis. However, smokers with allergic rhinitis had a threshold on the average of 3 doubling doses lower than smokers without allergic rhinitis. We concluded that there is a combined effect of chronic cigarette smoking and allergic rhinitis affecting nonspecific airway responsiveness.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D016210:Methacholine Chloride; D008688:Methacholine Compounds; D012123:Pulmonary Ventilation / Q000187:drug effects*; D006255:Rhinitis, Allergic, Seasonal / Q000503:physiopathology*; D012907:Smoking
chemical_list: D008688:Methacholine Compounds; D016210:Methacholine Chloride