title: Induction of somatic segregation by halogenated aliphatic hydrocarbons in Aspergillus nidulans.
abstract: 8 halogenated aliphatic hydrocarbons were assayed for their ability to induce somatic segregation in the mould Aspergillus nidulans. Induction of haploidization, mitotic non-disjunction and mitotic crossing-over was studied in heterozygous colonies exposed to the tested chemicals through the detection and phenotypic analysis of segregated sectors. The results obtained show that 1,2-dibromoethane induced all kinds of segregated sectors; 1,2-dichloroethane, allyl chloride, 2-chloroethanol, 2,2-dichloroethanol and 2,2-dichloroacetaldehyde significantly increased the frequency of haploid sectors and diploid non-disjunctional sectors; chloroform and 1,2-dichloropropane were ineffective.
mesh_terms: D001233:Aspergillus nidulans; D006238:Haploidy; D006846:Hydrocarbons, Halogenated / Q000633:toxicity*; D008938:Mitosis / Q000187:drug effects*; D009630:Nondisjunction, Genetic; D012854:Sister Chromatid Exchange / Q000187:drug effects
chemical_list: D006846:Hydrocarbons, Halogenated