[Renal function after anesthesia and abnormal surgery. A comparative study between halothane and epidural anesthesia].
Beta 2-microglobulin (BMG) and osmolarity (OSM) in the plasma and in the urine were measured in 23 adult female patients before and after abdominal surgery. Creatinine clearance (Ccr) and free water clearance (C-H2O) were determined simultaneously. These patients were divided into two groups, the first group receiving halothane anesthesia (n = 14) and the second group undergoing epidural anesthesia (n = 9). Results were summarised as follows. Ccr temporarily increased in both groups on the day of operation (0-POD) and on the 1st postoperative day (1-POD), suggesting a physiological compensation to the increased metabolic and circulatory needs in the post-operative state. Urinary BMG (U-BMG) concentration remarkably increased in both groups after the operation but the plasma BMG levels were unchanged. U-BMG returned to the pre-operative levels on the 4-POD in the 1st group and on the 2-POD in the 2nd group. Tubular dysfunction after anesthesia and surgery is believed to be responsible for this marked rise in U-BMG. The earlier recovery of U-BMG to the preoperative levels in the 2nd group indicates that the tubular dysfunction in epidural anesthesia is probably less in halothane anesthesia. The results of C-H2O and urine OSM studies also indicate the postoperative tubular dysfunction but these parameters may not be so sensitive as U-BMG.
D000005:Abdomen / Q000601:surgery*; D000328:Adult; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D003404:Creatinine / Q000097:blood; D005260:Female; D006221:Halothane; D006801:Humans; D007668:Kidney / Q000503:physiopathology*; D008875:Middle Aged; D009994:Osmolar Concentration; D011184:Postoperative Period; D001613:beta 2-Microglobulin / Q000378:metabolism
D001613:beta 2-Microglobulin; D003404:Creatinine; D006221:Halothane