Single-blind comparison of penbutolol and long-acting propranolol in general practice.
A multi-centre, single-blind trial was carried out in general practice to compare the therapeutic efficacy, tolerance and compliance of penbutolol and long-acting propranolol, both given once daily, in patients with mild to moderate hypertension. Two hundred and twenty-two patients (111 patients in each treatment group) completed the 8-week treatment period. On completion, diastolic blood pressure was under control in 60% of patients receiving penbutolol and in 55% of patients receiving long-acting propranolol. Tolerance of the trial medications was good. At the final assessment, 88.3% of patients receiving penbutolol and 93.7% of patients receiving long-acting propranolol indicated no problems on direct questioning. Side-effects, as elicited from a 24-item symptoms list, were similar for both treatments and were generally minimal. Compliance was good in both treatment groups.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D005194:Family Practice; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D010394:Penbutolol / Q000009:adverse effects / Q000627:therapeutic use*; D011412:Propanolamines / Q000627:therapeutic use*; D011433:Propranolol / Q000009:adverse effects / Q000627:therapeutic use*; D011897:Random Allocation; D013997:Time Factors
D011412:Propanolamines; D010394:Penbutolol; D011433:Propranolol