Tolerance and the H-Y antigen: Requirement for male T cells, but not B cells, to induce tolerance in neonatal female mice.
Transplantation tolerance of the H-Y antigen may be induced and transferred by lymphoid cells, but not by nonlymphoid cells. In this study we have demonstrated that amongst lymphoid cells, T cells--but not B cells or macrophages--are capable of inducing transplantation tolerance. In contrast, all three populations express sufficient amounts of immunogenic H-Y antigen to sensitize adult female mice to a subsequent male skin graft, as demonstrated by the second-set reaction.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D006182:H-Y Antigen / Q000276:immunology*; D007108:Immune Tolerance; D008198:Lymph Nodes / Q000166:cytology; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D012727:Sex Characteristics; D016038:Skin Transplantation; D013601:T-Lymphocytes / Q000276:immunology*; D014181:Transplantation Immunology
D006182:H-Y Antigen