title: Genotoxicity of the free-radical producers CCl4 and lipoperoxide in Aspergillus nidulans.
abstract: The false negative compounds, carbon tetrachloride and linoleic acid peroxide, induce somatic segregation in A. nidulans, but are negative or weak in inducing gene mutation in a haploid strain of the same organism. The other carcinogen tested, CHCl3, was negative in both tests. A model involving free-radical formation is proposed to explain the results. Finally, cysteamine, a free-radical scavenger, could partially counteract the genotoxicity of CCl4. The existence of carcinogens, predominantly capable of inducing chromosomal rearrangements through its action on structures other than DNA is stressed.
mesh_terms: D001233:Aspergillus nidulans / Q000187:drug effects; D002251:Carbon Tetrachloride / Q000633:toxicity*; D005609:Free Radicals; D008041:Linoleic Acids; D008054:Lipid Peroxides / Q000633:toxicity*; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D005609:Free Radicals; D008041:Linoleic Acids; D008054:Lipid Peroxides; D002251:Carbon Tetrachloride