title: [Progress in oral contraception. Advantages of a levonorgestrel-containing 3-stage preparation over low-dose levonorgestrel and desogestrel containing monophasic combination preparations].
abstract: The three-phase preparation, which contains levonorgestrel, has a number of advantages compared to the traditional monophase combination preparations. With the same contraceptive reliability its cycle stability is very much better than the monophase preparations, which are 40% high dosed in the progestin proportion (levonorgestrel and desogestrel). The dose relations of the new preparation agree with the most recent scientific knowledge on the metabolism aspects of hormonal contraceptives. The hormone dosage in the various phases of the menstrual cycle is largely adapted to the plasma level course of beta-oestradiol and progesterone in the corresponding phases of the normal cycle.
mesh_terms: D002986:Clinical Trials as Topic; D003276:Contraceptives, Oral / Q000627:therapeutic use*; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004997:Ethinyl Estradiol / Q000009:adverse effects / Q000627:therapeutic use*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D006801:Humans; D008597:Menstrual Cycle / Q000187:drug effects; D009640:Norethindrone / Q000009:adverse effects / Q000627:therapeutic use*; D009644:Norgestrel / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D004338:Drug Combinations; C020416:norethindrone acetate, ethinyl estradiol, ferrous fumarate drug combination; D009644:Norgestrel; D004997:Ethinyl Estradiol; D019304:Ethinyl Estradiol-Norgestrel Combination; D009640:Norethindrone
vernacular_title: Fortschritte in der oralen Kontrazeption. Vorteile eines Levonorgestrel-haltigen Dreistufenpräparates gegenüber niedrigdosierten Levonorgestrel- und Desogestrel-haltigen monophasischen Kombinationspräparaten.