The effect of insulin on Fru-2,6-P2 levels in human fibroblasts.
We report that fructose 2,6-bisphosphate (Fru-2,6-P2) levels in quiescent human fibroblasts stimulated with insulin treatment increase in a time- and dose-dependent manner. The biochemical role of the sugar phosphate in the cellular response to the hormone which controls carbohydrate metabolism and acts as mitogenic factor is discussed.
D002478:Cells, Cultured; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D005635:Fructosediphosphates / Q000378:metabolism*; D006598:Hexosediphosphates / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000494:pharmacology*; D007700:Kinetics; D012867:Skin / Q000378:metabolism*
D005635:Fructosediphosphates; D006598:Hexosediphosphates; D007328:Insulin; C029063:fructose-1,6-diphosphate