Effects of AET and MEA treatment prior to X-irradiation of mice on the first day of pregnancy.
Porton mice were whole-body X-irradiated with a dose of 500 R or, 15 minutes before X-irradiation, injected with AET or MEA, in a dose of 40 mg/kg of body weight, on the first day of pregnancy. On the nineteenth day of gestation, taking into consideration females in whose uteri live foetuses were observed, the increase in their body weight throughout pregnancy, the number of foetuses in the uterus, the body weight of foetuses, and the placenta weight were determined. As compared with controls, in X-irradiated mice and in those prior to exposure to X-rays, injected with AET or MEA, both statistically non-significantly greater placenta weight and statistically significantly lower increase in the female body weight during gestation, number of foetuses in the uterus, and body weight of foetuses, with the exception of statistically non-significantly lower number of female foetuses in only X-irradiated mice, number of male foetuses and body weight of female foetuses in those treated with AET, as well as total, female and male body weight in those injected with MEA were found. In females before X-irradiation injected with AET or MEA, in relation to those only X-irradiated, statistically significantly greater body weight of foetuses was observed.
D000818:Animals; D001835:Body Weight / Q000528:radiation effects; D003543:Cysteamine / Q000494:pharmacology*; D005260:Female; D005333:Fetus / Q000528:radiation effects; D008098:Litter Size / Q000528:radiation effects; D008297:Male; D051379:Mice; D011247:Pregnancy; D014916:Whole-Body Irradiation; D000338:beta-Aminoethyl Isothiourea / Q000494:pharmacology*
D000338:beta-Aminoethyl Isothiourea; D003543:Cysteamine