Therapeutic effect of cefotetan in an experimental local infection with facultative and obligate anaerobes in granuloma pouches in rats.
The therapeutic activities of cefotetan against experimentally induced infections with Escherichia coli. Serratia marcescens, Bacteroides fragilis or Fusobacterium mortiferum in the granuloma pouches of rats were compared with those of cefmetazole and cefazolin. Of these antibiotics, cefotetan showed the greatest therapeutic effect against the four bacterial infections after a single intramuscular administration. Cefotetan was found to give much higher pouch exudate concentrations than cefmetazole, and to show prolonged antibacterial levels even when compared with cefazolin. In the granuloma pouch, cefotetan produced similar morphological changes in the cells of E. coli NY-17 as have been observed in vitro by microscopy. Elongation and bulge formation were noted.
D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy*; D001442:Bacteroides Infections / Q000188:drug therapy; D001441:Bacteroides fragilis / Q000187:drug effects; D002437:Cefazolin / Q000627:therapeutic use; D015311:Cefmetazole; D015313:Cefotetan; D002513:Cephamycins / Q000627:therapeutic use*; D004927:Escherichia coli Infections / Q000188:drug therapy; D005674:Fusobacterium Infections / Q000188:drug therapy; D008297:Male; D008855:Microscopy, Electron, Scanning; D051381:Rats; D011919:Rats, Inbred Strains; D012706:Serratia marcescens / Q000187:drug effects
D002513:Cephamycins; D015311:Cefmetazole; D015313:Cefotetan; D002437:Cefazolin