Growth self-incitement in murine melanoma B16: a phenomenological model.
The growing murine melanoma B16 secretes increasing quantities of a substance or substances immunologically cross-reactive with insulin. The elevated concentrations of these substances in blood are accompanied by a decrease in blood glucose concentration and release of growth hormone, which is followed by increased tumor growth. By use of a phenomenological model based on these data, we show that B16 incites its own growth by positive feedback.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D013006:Growth Hormone / Q000097:blood; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D008433:Mathematics; D008545:Melanoma / Q000097:blood / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008954:Models, Biological
D001786:Blood Glucose; D007328:Insulin; D013006:Growth Hormone