Effect of biologically active compounds (anthracyclines and ethidium bromide) on some membrane-mediated processes in the course of viral infection. Investigations on a prokaryotic (bacteriophage-bacterium) system.
Anthracycline antibiotics--violamycin B1 and adriamycin--have an obvious effect on the efficiency of phage lambda L47.1 DNA transfection into E. coli Q358 cells. Treatment with anthracyclines of either phage DNA or bacterial cells results in a marked decrease in the number of transfectants per microgram DNA. On the other hand, adsorption of phage lambda gt WES to E. coli LE392 is considerably modified by exposure to anthracyclines of either the phage or the host cells.
D000327:Adsorption; D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic; D004279:DNA, Viral / Q000235:genetics; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D004996:Ethidium / Q000494:pharmacology*; D007700:Kinetics; D009279:Naphthacenes / Q000494:pharmacology; D014162:Transfection / Q000187:drug effects
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D004279:DNA, Viral; D009279:Naphthacenes; C022171:violamycin BI; D004317:Doxorubicin; D004996:Ethidium