title: Effects of neutral proteases from human leukocytes on plasma fibronectin.
abstract: Human plasma fibronectin (FN) is not susceptible to collagenase and gelatinase from human blood leukocytes. Leukocytic elastolytic protease (ELP) and cathepsin G (chymotrypsin-like protease, CLP) degrade FN to similar fragments. Among products of proteolysis by ELP and CLP fragments have been identified which bind to gelatin-fragment 40 kd, to fibrin-fragments 55 kd and 30 kd, and to heparin-fragment 30 kd.
mesh_terms: D010450:Endopeptidases / Q000494:pharmacology*; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D007962:Leukocytes / Q000201:enzymology*; D015260:Neprilysin
chemical_list: D005353:Fibronectins; D010450:Endopeptidases; D015260:Neprilysin