Creutzfeldt-Jakob disease: a case of 16 years' duration.
A 46-year-old man with Creutzfeldt-Jakob disease confirmed postmortem had a 16-year course of very slowly progressing incoordination and mental deterioration, suggesting Alzheimer's disease. The disease course transformed abruptly into a 7-week terminal phase of florid Creutzfeldt-Jakob disease. Dementing illnesses of unknown cause were present in the patient's paternal lineage.
D001921:Brain / Q000473:pathology; D002908:Chronic Disease; D007562:Creutzfeldt-Jakob Syndrome / Q000235:genetics / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged