Analysing antibody response based on data obtained from serial dilution methods.
We identify several problem areas in statistical analyses of data obtained from serial dilution methods in serology. We provide the mathematical backgrounds of the key elements involved in this field of study and discuss the statistical considerations. The problem areas include the use of the geometric mean as an expression of the average of a set of observations, the use of fold increase to measure antibody response, and the statistical analysis of the change in antibody response with respect to other variables, such as age and pre-titer levels.
D000328:Adult; D000906:Antibodies / Q000032:analysis*; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D002648:Child; D006801:Humans; D008722:Methods; D013223:Statistics as Topic; D014612:Vaccines / Q000276:immunology
D000906:Antibodies; D014612:Vaccines