title: Effect of a potassium-deficient diet on arterial blood pressure, plasma and tissue cations, and tissue norepinephrine in the hypertensive dog.
abstract: Chronic potassium deficiency in one-kidney one-clip hypertensive dogs significantly reduces blood pressure and plasma potassium, with a simultaneous increase in plasma renin activity. Tissue potassium concentration was decreased and tissue sodium concentration was increased in striated muscle and adrenal glands, which may suggest that the sodium-potassium pump was inhibited. In myocardium the sodium concentration was higher but the potassium concentration was not significantly lower than in control hypertensive dogs on normal diets. Arterial cation concentrations in the potassium-deficient group were not significantly different from those in the control group. Tissue norepinephrine concentration was higher in arteries from potassium-deficient animals, significantly so in the mesenteric and femoral arteries. The conclusion is that potassium deficiency may decrease blood pressure in the one-kidney one-clip hypertensive dogs by impairing the release of norepinephrine.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001834:Body Water / Q000378:metabolism; D002412:Cations / Q000378:metabolism; D004285:Dogs; D009638:Norepinephrine / Q000378:metabolism*; D011188:Potassium / Q000097:blood*; D011191:Potassium Deficiency / Q000503:physiopathology*; D012083:Renin / Q000097:blood*; D014018:Tissue Distribution
chemical_list: D002412:Cations; D012083:Renin; D011188:Potassium; D009638:Norepinephrine