title: [Graded chemotherapy and reduced radiotherapy in Hodgkin's disease in childhood. Intermediate report on the cooperative HD 82 therapy study].
abstract: The results of 111 children with Hodgkin's disease, who were treated with chemotherapy of different intensity and reduced radiotherapy (Cooperative Therapy Study HD 82, 12/81 - 9/83) are presented. There is no evidence that reduction of radiotherapy and selective splenectomy (splenectomy only in case of high probability of splenic involvement) induce a higher rate of relapses. All 87 patients with pathological stage I, II and IIIA are in first remission. 2 of 24 patients with stage IIIB/IV died of sepsis, 1 of those 24 patients relapsed. Splenectomy could be omitted in 2/3 of patients, in 75% of splenectomy splenic involvement was proved. 7% of all children get splenic irradiation.
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001317:Austria; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D005260:Female; D005860:Germany, West; D006689:Hodgkin Disease / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011241:Prednisone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D013156:Splenectomy; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D011344:Procarbazine; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone
vernacular_title: Abgestufte Chemotherapie und reduzierte Strahlentherapie beim Morbus Hodgkin im Kindesalter. Zwischenbericht der kooperativen Therapiestudie HD 82.