Estimation of glomerular filtration rate from beta 2-microglobulin serum levels in children.
In order to evaluate the usefulness of serum beta 2-microglobulin levels (SBM) in predicting the glomerular filtration rate (GFR) in children, SBM values were plotted against Cr51 EDTA clearance values in 34 children, age 18 months or older (49 determinations). A linear correlation was obtained when SBM values were logarithmically transformed. This relationship was significantly better than that between serum creatinine corrected for body height (Ht/SCR) and Cr51 EDTA clearance. The scatter around the regression line, especially for the lower log SBM values was, however, too large to permit an acceptable prediction of the GFR. Correction of the SBM values for height did not significantly alter this relationship. We conclude from our findings that, although there is a good linear correlation between log SBM and GFR, the latter cannot be predicted within acceptable limits from SBM values in children.
D000293:Adolescent; D000367:Age Factors; D001827:Body Height; D002648:Child; D002675:Child, Preschool; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007674:Kidney Diseases / Q000097:blood* / Q000175:diagnosis; D008297:Male; D011379:Prognosis; D001613:beta 2-Microglobulin / Q000032:analysis*
D001613:beta 2-Microglobulin