Inhibition of adhesion of Escherichia coli K88 antigen by mammary secretions of susceptible and resistant sows.
Anti-adhesive activities of colostrum and milk from genetically susceptible sows, which protected their susceptible offspring in an outbreak of neonatal diarrhoea caused by K88-positive Escherichia coli, were compared with the activities in mammary secretions of resistant dams that did not protect their susceptible progeny. There was significantly more anti-adhesive antibody in the secretions of susceptible sows than in resistant sows, both during the disease period, and 1 year later. Fractionation of colostrum by gel filtration and ion-exchange chromatography led to identification of the anti-adhesive antibodies as including both IgA and IgM.
D000818:Animals; D000831:Animals, Newborn; D000907:Antibodies, Bacterial / Q000276:immunology*; D000937:Antigen-Antibody Reactions; D000942:Antigens, Bacterial; D000954:Antigens, Surface / Q000276:immunology*; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D003126:Colostrum / Q000276:immunology*; D003967:Diarrhea / Q000276:immunology / Q000662:veterinary; D004926:Escherichia coli / Q000276:immunology*; D029968:Escherichia coli Proteins; D005260:Female; D036781:Fimbriae Proteins; D007070:Immunoglobulin A / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008892:Milk / Q000276:immunology*; D011247:Pregnancy; D013552:Swine / Q000276:immunology*; D013553:Swine Diseases / Q000276:immunology
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000954:Antigens, Surface; D029968:Escherichia coli Proteins; D007070:Immunoglobulin A; D007075:Immunoglobulin M; C026888:K88 antigen, E coli; D036781:Fimbriae Proteins