Potassium-sparing diuretics: interaction with digoxin in elderly men.
The effects of two potassium-sparing diuretic combination drugs, triamterene-hydrochlorothiazide and spironolactone-hydrochlorothiazide, were compared with those of two kaliuretic diuretics, hydrochlorothiazide and furosemide, in order to ascertain the effects of those diuretics on concentrations of serum digoxin, serum potassium, and erythrocyte potassium, and to determine whether any of these diuretics should be preferred for patients taking digoxin. It was concluded that in patients for whom potassium depletion may lead to digoxin toxicity, a potassium-sparing diuretic may safely be used in order to reduce potassium excretion and thereby reduce the risk of arrhythmias.
D000368:Aged; D002986:Clinical Trials as Topic; D004077:Digoxin / Q000097:blood*; D004232:Diuretics / Q000627:therapeutic use*; D004347:Drug Interactions; D004912:Erythrocytes / Q000032:analysis*; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood*; D013148:Spironolactone / Q000627:therapeutic use; D014223:Triamterene / Q000627:therapeutic use
D004232:Diuretics; D006852:Hydrochlorothiazide; D013148:Spironolactone; D004077:Digoxin; D005665:Furosemide; D011188:Potassium; D014223:Triamterene