Arachidonic acid metabolism and macrophage activation.
The macrophage is an important source of arachidonic acid metabolites, which possess a wide variety of functions with regard to the initiation and regulation of inflammatory responses. Because of the central role of macrophages in the induction of immunity as well as their participation in chronic inflammation, an understanding of their potent arachidonic acid products may aid in the therapeutic manipulation of inflammatory disease.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism*; D001202:Ascitic Fluid / Q000276:immunology; D011464:Epoprostenol / Q000378:metabolism; D006168:Guinea Pigs; D007111:Immunity, Cellular / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology; D007249:Inflammation / Q000188:drug therapy / Q000276:immunology; D008222:Lymphokines / Q000502:physiology; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D010743:Phospholipids / Q000378:metabolism; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011453:Prostaglandins / Q000378:metabolism; D011817:Rabbits; D051381:Rats
D001095:Arachidonic Acids; D008222:Lymphokines; D010743:Phospholipids; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D011464:Epoprostenol; D007213:Indomethacin