Improving the production of monensin by Streptomyces cinnamonensis.
The production of monensin by Streptomyces cinnamonensis was increased by genetic improvement of the strain and by modification of cultivation conditions. The selection of a suitable strain and optimization of the fermentation process (temperature, aeration, addition of esters of oleic acid) resulted in a 30 fold increase of the monensin production.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001431:Bacteriological Techniques; D005663:Furans / Q000096:biosynthesis*; D005786:Gene Expression Regulation; D008985:Monensin / Q000096:biosynthesis*; D013291:Streptococcus / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D005663:Furans; D008985:Monensin