Treatment of glaucoma using minidrops of clonidine.
A single regular (70 microL) or mini (15 microL) eyedrop of 0% (placebo), 0.25%, and 0.50% strengths of clonidine hydrochloride was administered to 16 patients with open-angle glaucoma in a double-masked crossover study. Both the regular drops and minidrops of 0.25% and 0.50% concentrations of the drug substantially lowered the intraocular pressure over a five-hour period as compared with the placebo. Only the regular drops of 0.50% clonidine substantially lowered the systemic BP. These results indicate the value of using a smaller volume of clonidine drop as an ocular hypotensive agent to avoid systemic effects.
D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003000:Clonidine / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions
D009883:Ophthalmic Solutions; D003000:Clonidine