Association of hepatitis B (HBs) antigenaemia and membranous glomerulonephritis in Zimbabwean children.
8 Zimbabwean children are discussed in whom the nephrotic syndrome (NS) was a manifestation of membranous glomerulonephritis (GN) which was associated in every case with hepatitis B antigenaemia. This marks the first occasion that such an association has been reported in African children, although it has been thoroughly documented in children in Europe, the Far East and America. Microhaematuria, hypertension and mild to moderate renal insufficiency were frequent early associated findings, and every child exhibited hypocomplementaemia and a markedly diminished immunoglobulin G (IgG) level. The disease followed a benign course in the majority, and only 1 child died in renal failure.
D000293:Adolescent; D002353:Carrier State / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003165:Complement System Proteins / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000276:immunology*; D005923:Glomerulosclerosis, Focal Segmental / Q000276:immunology; D006509:Hepatitis B / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism; D007678:Kidney Glomerulus / Q000276:immunology; D008288:Malaria / Q000276:immunology; D009404:Nephrotic Syndrome / Q000276:immunology; D012552:Schistosomiasis / Q000276:immunology; D015030:Zimbabwe
D006514:Hepatitis B Surface Antigens; D007136:Immunoglobulins; D003165:Complement System Proteins