Coexisting primary malignant lymphoma and adenocarcinoma of the large intestine in an IgA-deficient boy.
This is a case report of an IgA-deficient adolescent male (14 years old) presenting with coexisting adenocarcinoma and adenomatous polyp of the rectosigmoid, and a primary lymphoma of the cecum (large-cell, histiocytic type). A 14-year-old sister of the patient had died of gastric carcinoma. Her serum immunoglobulins were not measured. The literature regarding the coexisting primary malignant lymphoma and adenocarcinoma of the colon, as well as neoplasia associated with IgA deficiency, is reviewed and pertinent literature discussed.
D000230:Adenocarcinoma / Q000473:pathology*; D000293:Adolescent; D002430:Cecal Neoplasms / Q000276:immunology*; D004406:Dysgammaglobulinemia / Q000473:pathology; D006801:Humans; D017098:IgA Deficiency; D007417:Intestinal Polyps / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology*; D008297:Male; D009378:Neoplasms, Multiple Primary; D012004:Rectal Neoplasms / Q000473:pathology*; D012811:Sigmoid Neoplasms / Q000473:pathology*