Nonbacterial inflammation as a means of enhancing skin flap survival.
Painting the skin of the dorsum of a rat with croton oil improved the survival length of caudally based skin flaps. No vasodilation was demonstrated in the deeper layers of skin treated with croton oil. The mechanism by which the application of croton oil leads to improvement of the skin flap survival is thought to be the nonbacterial inflammation produced by the croton oil (a chemical burn). This inflammatory effect probably acts upon the microcirculation via arachidonic acid metabolite mediators.
D000818:Animals; D002057:Burns, Chemical / Q000473:pathology; D003436:Croton Oil; D006085:Graft Survival; D006258:Head and Neck Neoplasms / Q000601:surgery; D006801:Humans; D007249:Inflammation / Q000139:chemically induced*; D008833:Microcirculation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects / Q000473:pathology; D013524:Surgical Flaps; D013997:Time Factors; D014945:Wound Healing
D003436:Croton Oil