Effects of bupropion on body weight.
Patients' weights were assessed during placebo-controlled, amitriptyline-controlled, and uncontrolled bupropion trials. Low-moderate (50-450 mg/day) to moderate-high (300-750 mg/day) doses of bupropion were consistently associated with a lack of weight gain (average weight loss of 1-2 pounds); placebo was associated with an average weight gain of 1 lb and 75-225 mg/day of amitriptyline was associated with an increase of 3-9 lb. Bupropion treatment was rarely accompanied by reports of appetite change and had no statistically significant effect on caloric intake when compared to placebo.
D000639:Amitriptyline / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001066:Appetite / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects*; D016642:Bupropion; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D002149:Energy Intake / Q000187:drug effects; D006801:Humans; D010919:Placebos; D011427:Propiophenones / Q000494:pharmacology / Q000627:therapeutic use*
D000928:Antidepressive Agents; D010919:Placebos; D011427:Propiophenones; D016642:Bupropion; D000639:Amitriptyline