Action of different gamma interferons on mouse leukemic cells resistant to alpha and beta interferons.
Phytohemagglutinin-induced interferon-gamma (IFN-gamma) was reported to act on mouse leukemic L1210 R cells resistant to IFN-alpha and -beta. Results reported here show that these cells are also sensitive to various preparations of murine IFN-gamma derived from different sources and purified to different degrees and that lymphokines present in the preparations are not involved in the antiviral effect of IFN. In addition, IFN-gamma preparation increases concanavalin A binding to L1210 S and L1210 R cells indicating that the sensitivity of L1210 R cells to IFN-gamma is not limited to its antiviral effect.
D000818:Animals; D002478:Cells, Cultured; D007370:Interferon Type I / Q000276:immunology*; D007371:Interferon-gamma / Q000276:immunology*; D007939:Leukemia L1210 / Q000276:immunology*; D008222:Lymphokines / Q000276:immunology; D051379:Mice; D008819:Mice, Nude; D010835:Phytohemagglutinins / Q000494:pharmacology
D007370:Interferon Type I; D008222:Lymphokines; D010835:Phytohemagglutinins; D007371:Interferon-gamma