Immunofluorescent analysis of renal biopsies in uncomplicated Schistosoma haematobium infections in children.
Renal biopsies were studied by light and immunofluorescent microscopy in 13 young individuals with uncomplicated Schistosoma haematobium infections. Slight mesangial cell proliferation and matrix increase were found in three biopsies and focal interstitial inflammatory infiltrates were noted in six. However extensive IgG (nine cases) and IgM (seven cases) granular deposits were found in the mesangial areas. C3 was found in only three of these cases. Clq, fibrinogen, IgA and IgE were not found deposited except for one case with IgE. Schistosome antigen was identified in mesangial areas in four biopsies after acid treatment of the sections. It appears the immune complexes are deposited consistently in the renal glomeruli in S. haematobium infections but their role in inducing clinical renal disease is minimal.
D001706:Biopsy; D002648:Child; D005455:Fluorescent Antibody Technique; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007668:Kidney / Q000473:pathology*; D007678:Kidney Glomerulus / Q000276:immunology*; D012548:Schistosoma haematobium; D012552:Schistosomiasis / Q000473:pathology*
D007074:Immunoglobulin G; D007075:Immunoglobulin M