Efficacy of activated charcoal and other agents in the reduction of hepatotoxic effects of a single dose of aflatoxin B1 in chickens.
Liver injury caused by a toxic dose of aflatoxin B1 (AFB1) (6 mg/kg, p.o.) in experimental chickens was measured by observing changes in hepatic microsomal cytochrome P-450 and the activity of microsomal benzphetamine N-demethylase and serum glutamic oxaloacetic transaminase (SGOT). However, simultaneous administration of activated charcoal, reduced glutathione (GSH), cysteine, selenium, beta-carotene or fisetin with aflatoxin B1 considerably reduced the toxic injury to liver as measured by the above parameters.
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000037:antagonists & inhibitors*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001589:Benzphetamine / Q000378:metabolism; D002606:Charcoal / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury; D002645:Chickens; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D008107:Liver Diseases / Q000517:prevention & control*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology
D000348:Aflatoxins; D001589:Benzphetamine; D002606:Charcoal; D003577:Cytochrome P-450 Enzyme System; D016604:Aflatoxin B1; D001219:Aspartate Aminotransferases