[Role of calcitonin in pregnant rats : interaction with 1,25-dihydroxycholecalciferol on fetal bone resorption in vivo/in vitro].
We studied in pregnant Rat the effect of 1,25-dihydroxycholecalciferol (1,25(OH)2D3) alone or associated with calcitonin on fetal bone resorption measured by organ culture. 1,25(OH)2D3 (0.1 microgram per day) reduced fetal weight and increased fetal bone resorption. Calcitonin (30 mU/hr.) alone had no significant effects but, associated with 1,25(OH)2D3, it protected mother and foetus against the effect of the vitamin D3 metabolite.
D000818:Animals; D001862:Bone Resorption / Q000187:drug effects*; D002116:Calcitonin / Q000494:pharmacology / Q000502:physiology*; D002117:Calcitriol / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D005260:Female; D005333:Fetus / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D002116:Calcitonin; D002117:Calcitriol; D002118:Calcium
Rôle de la calcitonine chez la ratte gestante; interaction avec le 1.25-dihydroxycholécalciférol sur la résorption osseuse faetale in vivo/in vitro.