Extremely high circulating levels of 1 alpha,25-dihydroxyvitamin D3 in the marmoset, a new world monkey.
Compared to most mammals, the marmoset, a new world monkey, requires particularly large amounts of vitamin D to maintain normal growth. We compared serum concentrations of vitamin D metabolites in marmosets with rhesus monkeys and humans. The circulating levels of 1 alpha,25-dihydroxyvitamin D3 [1 alpha,25(OH)2D3] in marmosets were 4 to 10 times higher than those in rhesus monkeys and humans. But none of the marmosets exhibited hypercalcemia. In two marmosets which had suffered bone fractures, the 1 alpha,25(OH)2D3 levels were particularly elevated. These results suggest that the marmoset has an end-organ resistance to 1 alpha,25(OH)2D3.
D015650:24,25-Dihydroxyvitamin D 3; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D002112:Calcifediol / Q000097:blood; D002117:Calcitriol / Q000097:blood*; D002118:Calcium / Q000097:blood; D002143:Callitrichinae / Q000097:blood*; D004100:Dihydroxycholecalciferols / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D010758:Phosphorus / Q000097:blood; D012016:Reference Values; D013045:Species Specificity; D014316:Tritium
D004100:Dihydroxycholecalciferols; D014316:Tritium; D010758:Phosphorus; D015650:24,25-Dihydroxyvitamin D 3; D000469:Alkaline Phosphatase; D002117:Calcitriol; D002112:Calcifediol; D002118:Calcium