Mutagenicity of hydrazides of pyrimidine-nucleotide-precursors in the Salmonella-oxygenase test.
Five newly synthesized hydrazides: L-aspartic acid dihydrazide, DL-ureido-succinic acid dihydrazide, DL-dihydroorotic acid hydrazide, orotic acid hydrazide, and 2,2'-anhydro-1-(beta-D-arabinofuranosyl)-orotic acid hydrazide were tested for mutagenicity in the Ames test. All these hydrazides except DL-ureidosuccinic acid dihydrazide were found to be non-mutagenic. The mutagenic activities of the latter compound which causes base-pair substitution was decreased in the presence of metabolic activator.
D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D001482:Base Composition / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006834:Hydrazines / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D012486:Salmonella typhimurium / Q000187:drug effects
D000963:Antimetabolites; D006834:Hydrazines; D001224:Aspartic Acid; C027192:ureidosuccinic acid dihydrazide