[Assay of C-peptide in diabetes in children and adolescents].
Thirty eight children and adolescents aged 3 to 19 years with insulin-dependent diabetes had basal plasma C-peptide levels 50 to 70 p. 100 lower than comparable non-diabetic subjects. An appreciable residual fasting endogenic secretion greater than 1 ng/ml was found in half the patients during the first two years after the onset of diabetes. After this period, the concentrations were almost always lower than 1 ng/ml and in half the cases, at the lower limit of detection. In addition, it was difficult to stimulate C-peptide secretion by food or drugs. The effects of variations in blood glucose were made allowance for by using molar C-peptide/glucose ratio. This gives a better evaluation of the inverse relationship between residual pancreatic function and the duration of the diabetes and of the degree of residual beta-langerhans secretion to help obtain stable metabolic equilibrium.
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000503:physiopathology; D008297:Male; D013997:Time Factors
D001786:Blood Glucose; D002096:C-Peptide; D007328:Insulin
Dosage du peptide C dans le diabète de l'enfant et de l'adolescent.