Antibiotic prophylaxis in transurethral surgery.
In a prospective randomized double-blind study, perioperative prophylaxis with cefoperazone, a third-generation cephalosporin, in transurethral surgery was evaluated. Cefoperazone significantly lowered the urinary tract infection rate from 17 per cent to 0 per cent, five to seven days postoperatively. Results from the latest placebo-controlled studies concerning antibiotic prophylaxis in transurethral surgery are summarized, and the use of antibiotic prophylaxis is discussed and recommended.
D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002438:Cefoperazone / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008722:Methods; D010919:Placebos; D011292:Premedication; D011897:Random Allocation; D014521:Urethra; D014552:Urinary Tract Infections / Q000517:prevention & control; D014570:Urologic Diseases / Q000601:surgery*
D000900:Anti-Bacterial Agents; D010919:Placebos; D002438:Cefoperazone