Antimutagenic effects of cinnamaldehyde on chemical mutagenesis in Escherichia coli.
Antimutagenic effects of cinnamaldehyde on mutagenesis by chemical agents were investigated in Escherichia coli WP2 uvrA- trpE-. Cinnamaldehyde, when added to agar medium, greatly reduced the number of Trp+ revertants induced by 4-nitroquinoline 1-oxide (4-NQO) without any decrease of cell viability. This antimutagenic effect could not be explained by inactivation of 4-NQO caused by direct interaction with cinnamaldehyde. Mutagenesis by furylfuramide (AF-2) was also suppressed significantly. Mutations induced by methyl methanesulfonate (MMS) and ethyl methanesulfonate (EMS) were slightly inhibited. However, cinnamaldehyde was not at all effective on the mutagenesis of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). Two derivatives of cinnamaldehyde, cinnamyl alcohol and trans-cinnamic acid, did not have as strong antimutagenic effects on 4-NQO mutagenesis as cinnamaldehyde had. Because cinnamaldehyde showed marked antimutagenic effects against mutations induced by UV-mimic mutagens but not those induced by MNNG or EMS, it seems that cinnamaldehyde might act by interfering with an inducible error-prone DNA repair pathway.
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D000171:Acrolein / Q000031:analogs & derivatives / Q000494:pharmacology*; D000447:Aldehydes / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D005668:Furylfuramide / Q000494:pharmacology; D009153:Mutagens / Q000494:pharmacology; D009154:Mutation
D000447:Aldehydes; D009153:Mutagens; D005668:Furylfuramide; D015112:4-Nitroquinoline-1-oxide; D000171:Acrolein; C012843:cinnamaldehyde