Reversal of the muscle relaxant effect of diazepam but not of progabide by a specific benzodiazepine antagonist: Ro 15-1788.
The muscle relaxant effects of diazepam and progabide were studied in mutant Han-Wistar rats which exhibit spontaneous tonic activity in the electromyogram of the gastrocnemius-soleus muscle. Treatment with diazepam or progabide produced a dose-related reduction of the spontaneous activity measured in the electromyogram. The depressant effect of diazepam, but not that of progabide was antagonized by the specific benzodiazepine antagonist Ro 15-1788. From these data it is apparent that the muscle relaxant effect of progabide is not mediated through an alteration of benzodiazepine receptors.
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D003975:Diazepam / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005260:Female; D005442:Flumazenil; D018756:GABA Antagonists; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D001570:Benzodiazepinones; D018756:GABA Antagonists; D009125:Muscle Relaxants, Central; C017985:progabide; D005442:Flumazenil; D005680:gamma-Aminobutyric Acid; D003975:Diazepam