Naloxone in shock and toxic coma.
In summary, naloxone has proved to be effective and safe during its years of use for narcotic antagonism. Its usefulness in non-narcotic coma and shock remains controversial, although some encouraging but inconclusive evidence exists. The final answer lies on the horizon of medicine; it awaits further delineation of the role of endogenous opioids in health and disease and clear statistical verification of naloxone's efficacy in such disease states.
D000818:Animals; D001143:Arousal / Q000187:drug effects*; D003128:Coma / Q000188:drug therapy; D006801:Humans; D009270:Naloxone / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D012769:Shock / Q000188:drug therapy*; D012770:Shock, Cardiogenic / Q000188:drug therapy; D012771:Shock, Hemorrhagic / Q000188:drug therapy; D012772:Shock, Septic / Q000188:drug therapy
D009270:Naloxone