Genetic control of rheumatoid factor production in the mouse. Role of genes linked to the immunoglobulin heavy chain locus and to the major histocompatibility complex.
The influence of Igh-1 and H-2 linked genes on the production of IgG2a-specific rheumatoid factors (RF) by 129/Sv mice was examined. Heterozygous animals carrying the 129 alleles, H-2b and Igh-1a, and either H-2k, H-2a, or Igh-1b (but not Igh-1d or Igh-1e) had considerably reduced RF levels. In contrast, Igh-1b linked genes failed to suppress RF production by MRL/MpJ-lpr mice. This lack of suppression was linked to the lymphoproliferation trait characteristic of these animals.
D000818:Animals; D003433:Crosses, Genetic; D005838:Genotype; D006183:H-2 Antigens / Q000276:immunology; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D008285:Major Histocompatibility Complex; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D012217:Rheumatoid Factor / Q000096:biosynthesis / Q000235:genetics*
D006183:H-2 Antigens; D007143:Immunoglobulin Heavy Chains; D012217:Rheumatoid Factor