[Metabolic factors determining the selective enhancement of the effect of ionizing radiation on tumors].
Two alternative approaches to enhance the damaging effect of X-rays on radioresistant tumours are discussed. One of them, hypoxyradiotherapy, suggests a preferential protection of normal host tissue, the other, short-term hyperglycemia, is directed to a selective intensification of tumour destruction. Both approaches take into account peculiarities of tumour metabolism. Theoretical considerations are put forward and experimental data are described elucidating the mechanisms of the selective action of hyperglycemia on the tumour and specifying the conditions which significantly enhance the antitumour radiation effect. In particular, a way to enhance the postradiation effect on tumour cells results in their interphase death. A combined use of gas hypoxia, hyperglycemia and hyperthermia is substantiated.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism / Q000473:pathology / Q000532:radiotherapy; D002470:Cell Survival / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005947:Glucose / Q000378:metabolism*; D006019:Glycolysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008545:Melanoma / Q000378:metabolism / Q000532:radiotherapy; D009369:Neoplasms / Q000378:metabolism / Q000532:radiotherapy*; D010101:Oxygen Consumption; D011836:Radiation Tolerance; D012878:Skin Neoplasms / Q000378:metabolism / Q000532:radiotherapy
D005947:Glucose
Metabolicheskie faktory, opredeliaiushchie izbiratel'noe usilenie deĭstviia ioniziruiushchikh izlucheniĭ na opukholi.