Acetaminophen overdose.
N-acetylcysteine (NAC) is the treatment of choice for acetaminophen overdose. With this therapy, morbidity from overdose can be held to a minimum. Mortality is rare in any case and virtually nonexistent in treated patients. Unless a high index of suspicion is maintained, the diagnosis may be missed until it is too late for effective antidotal treatment.
D000082:Acetaminophen / Q000266:history / Q000378:metabolism / Q000506:poisoning*; D000111:Acetylcysteine / Q000378:metabolism / Q000627:therapeutic use*; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D001711:Biotransformation; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D003545:Cysteine / Q000096:biosynthesis; D004305:Dose-Response Relationship, Drug; D005978:Glutathione / Q000378:metabolism; D049673:History, 20th Century; D006801:Humans; D007700:Kinetics; D008107:Liver Diseases / Q000188:drug therapy; D011379:Prognosis; D011517:Prothrombin Time; D013997:Time Factors
D000082:Acetaminophen; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005978:Glutathione; D003545:Cysteine; D001663:Bilirubin; D000111:Acetylcysteine