In vitro and in vivo antifungal activity of the combination methylpartricin-5-fluorocytosine.
In vitro studies on the antifungal activity exerted by the combinations SPA-S-222 (a hydrosoluble derivative of the polyene antibiotic methylpartricin) and 5-fluorocytosine evidence a favourable interaction against the formation of germ-tube in Candida albicans; against Cryptococcus neoformans and 5FC induced-resistant strains of Candida albicans. In the experimental infections with Candida albicans and Cryptococcus neoformans a significantly favourable interaction was exerted by polyene-5FC combinations.
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D002177:Candidiasis / Q000188:drug therapy; D003455:Cryptococcus neoformans / Q000187:drug effects; D003596:Cytosine / Q000031:analogs & derivatives*; D004338:Drug Combinations; D004357:Drug Synergism; D005437:Flucytosine / Q000494:pharmacology*; D008613:Mepartricin / Q000494:pharmacology*; D051379:Mice; D011090:Polyenes / Q000494:pharmacology*
D000935:Antifungal Agents; D004338:Drug Combinations; D011090:Polyenes; D008613:Mepartricin; D003596:Cytosine; D005437:Flucytosine