Is there a local production of nitrosamines by the vaginal microflora in anaerobic vaginosis/trichomoniasis?
Nitrosamines have been identified in vaginal secretions of women with trichomoniasis. Both nitrites and amines the elements for nitrosamine synthesis are produced by the abnormal-predominantly anaerobic-vaginal flora of patients with bacterial vaginosis/trichomoniasis. The final formation of nitrosamines could also depend on microbial enzymatic activity. The confirmation of an endogenous generation of oncogenic nitrosamines in the vaginas of some women could give promising impulses to cancer-research concerning the uterine cervix.
D000693:Anaerobiosis; D005260:Female; D006801:Humans; D009602:Nitrosamines / Q000096:biosynthesis*; D014247:Trichomonas Vaginitis / Q000378:metabolism*; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000382:microbiology; D014621:Vagina / Q000382:microbiology*; D014623:Vaginal Diseases / Q000378:metabolism*
D009602:Nitrosamines