Quantitative histochemical estimation of the DNA content of the main histological types of lung cancer, with particular reference to the diagnosis of the degree of differentiation.
The results of microspectrophotometric measurements of the content of DNA of the cell nuclei developed in the zones of growth of 52 neoplasms of the lung of different histological types and degree of differentiation are shown. It was found that the growth of anaplasia of the tumour tissue to be characterized by increased "DNA Accumulation Index" and increased polyploidy. The authors think that quantitative determination of the DNA may be of value as an objective diagnostic test of malignization and degree of differentiation of lung cancer.
D002454:Cell Differentiation; D002467:Cell Nucleus / Q000032:analysis; D004273:DNA, Neoplasm / Q000032:analysis*; D004847:Epithelial Cells; D006651:Histocytochemistry; D006801:Humans; D008175:Lung Neoplasms / Q000032:analysis* / Q000473:pathology
D004273:DNA, Neoplasm