Influence of dietary cadmium and chelators on the survival of Drosophila.
Dietary cadmium chloride at concentrations of 1 X 10(-4) M or greater shorten the life span of Drosophila melanogaster by as much as 74%. The chelator, CDTA, inhibits the normal age-related cadmium accumulation in whole flies and also improves the median life span by 20%. These data are interpreted to indicate that dietary cadmium may be a determining factor for the onset of senescence.
D000375:Aging; D000818:Animals; D002104:Cadmium / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D019256:Cadmium Chloride; D002614:Chelating Agents / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000187:drug effects*; D008297:Male; D013997:Time Factors
D002614:Chelating Agents; D002104:Cadmium; D019256:Cadmium Chloride