Prior behavioral experience can reverse the effects of morphine.
Morphine administration typically decreases responding of squirrel monkeys trained to avoid electric shock. However, the rate-decreasing effects of morphine on avoidance responding were reversed after either concurrent or prior exposure to a condition in which responding was maintained by shock presentation. These findings demonstrate that behavioral experience can play a significant role in determining the behavioral effects of drugs and that specific types of environmental conditions can completely reverse the usual effects those drugs have on behavior.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000502:physiology*; D004597:Electroshock; D005108:Extinction, Psychological / Q000187:drug effects; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D012453:Saimiri
D009020:Morphine