The efficiency of nebulization treatment with water compared to sodium cromoglycate in reducing upper respiratory infections in children.
Twenty-two children aged 1 to 5 years with history of recurrent upper respiratory infections (URI) were investigated in a double blind cross over clinical study. After a three week observation period, patients received, at random, over two alternating periods of six weeks each, either 2 ml placebo (water) or 1% sodium cromoglycate (SC) solution t.i.d. by means of a home nebulizer. A significant decline in the number of illness days during both the nebulization periods as compared to the pretreatment period was observed (a mean percentage of days of 13.7 and 36.1 respectively, p less than 0.001). Both types of nebulization were equally efficient in reducing URI morbidity. The present study indicates that humidification may have some beneficial effect on reducing the recurrence rate of URI. Sodium cromoglycate was not superior to water for this purpose.
D002675:Child, Preschool; D004205:Cromolyn Sodium / Q000008:administration & dosage* / Q000627:therapeutic use; D004311:Double-Blind Method; D006801:Humans; D007223:Infant; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D014835:Volatilization; D014867:Water / Q000627:therapeutic use*
D014867:Water; D004205:Cromolyn Sodium