Plasma lipids in women using progestogen-only oral contraceptives.
Using a strict protocol, in an attempt to avoid confounding factors, healthy women were assigned at random to a continuous daily dose of either 30 micrograms levonorgestrel or 350 micrograms norethisterone. Volunteers were either aged 40-45 years, or were less than 30 years and 8-12 weeks post partum. Blood plasma lipids and lipoproteins were measured on specimens collected in the fasting state before treatment, then every month during progestogen treatment. After 6 months there was a small increase in plasma triglycerides, especially in older women, and also in a non-lactating younger group. Changes in lipoprotein-cholesterol fractions were insignificant, though there were significant pretreatment differences between the various groups.
D000328:Adult; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003277:Contraceptives, Oral, Combined / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007774:Lactation; D016912:Levonorgestrel; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008875:Middle Aged; D009640:Norethindrone / Q000627:therapeutic use*; D009644:Norgestrel / Q000627:therapeutic use*; D011247:Pregnancy; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003277:Contraceptives, Oral, Combined; D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D009644:Norgestrel; D016912:Levonorgestrel; D002784:Cholesterol; D009640:Norethindrone