Actinomycotic osteomyelitis of the facial bones and mandible.
Actinomyces israelii is a part of the human oral flora and thus is more commensal than pathogenic. Oral trauma, accidental or purposeful, can precipitate its introduction into the soft tissues, to which infection is usually confined. The case presented is one in which, over a span of two decades (1956 to 1977), the extraction of a mandibular tooth resulted in a chronic actinomycotic osteomyelitis, destroying first the mandible, then both maxillae, and then the right zygoma, with decreased vision and proptosis despite repeated medical and surgical intervention. Adequate treatment required removal of the sequestrum and excision of all infected granulation tissue, scars, and involucra until healthy bone was exposed. Intravenous penicillin was administered for 2 weeks, followed by a 6-month course of oral penicillin. The patient was followed for 4 years and remained disease free.
D000196:Actinomycosis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology / Q000601:surgery; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002908:Chronic Disease; D005147:Facial Bones / Q000382:microbiology*; D006801:Humans; D008297:Male; D008336:Mandibular Diseases / Q000382:microbiology*; D008875:Middle Aged; D010019:Osteomyelitis / Q000188:drug therapy / Q000382:microbiology* / Q000473:pathology / Q000601:surgery
D000900:Anti-Bacterial Agents