[Pituitary-gonadal function following therapy of testicular relapse in boys with acute lymphoblastic leukemia].
Testicular function was evaluated in 8 boys with acute lymphoblastic leukemia (ALL) and testicular relapse following another course of intensive chemotherapy with unilateral or bilateral orchidectomy and/or testicular irradiation. LH- and FSH-secretion was studied in all using a standardized LHRH-test. In addition, a HCG-test was performed in 6 boys. In prepuberty, all boys examined showed normal LH- and FSH-values. Beginning at 9 to 10 years, elevated basal and/or stimulated LH- and FSH-values were occasionally noted in contrast to the consistently elevated values after the age of 12. Using the HCG-test, we found a testosterone response only in patients receiving gonadal irradiation of 1 100 and 1 500 rads (2 patients). No response was elicited in those with radiation doses of 2 400 and 3 000 rads. We conclude that high dose gonadal irradiation and chemotherapy cause temporary and possibly permanent impairment of spermatogenesis and Leydig cell function in boys with ALL and testicular relapse.
D002369:Castration; D002648:Child; D002675:Child, Preschool; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy* / Q000532:radiotherapy; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009364:Neoplasm Recurrence, Local; D010902:Pituitary Gland / Q000503:physiopathology*; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D013737:Testis / Q000503:physiopathology*; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Die hypophysäre-gonadale Funktion nach Therapie eines Hodenrezidivs bei Jungen mit akuter lymphoblastischer Leukämie.