Mitomycin C extravasation injuries.
Mitomycin C extravasation produces a chronic painful ulceration similar to that of adriamycin. Pain marks the extravasation of this chemotherapeutic agent when it occurs. A complaint of pain during mitomycin administration should prompt immediate cessation of infusion and regular frequent follow-up. Ulceration may not appear for one to two weeks after initial injury. Wide local excision with subsequent split thickness skin grafting is recommended.
D005260:Female; D006801:Humans; D007263:Infusions, Parenteral / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000009:adverse effects*; D011379:Prognosis; D016038:Skin Transplantation; D012883:Skin Ulcer / Q000139:chemically induced* / Q000601:surgery
D008937:Mitomycins; D016685:Mitomycin