Stereostructure-activity relationships of the GABA-containing cis-decahydroquinoline-5-carboxylic acids; intracerebroventricular studies in mice.
Two cis-decahydroquinoline-5-carboxylic acids, cis-1 and 2 were investigated for their pharmacological activities in vivo. Intracerebroventricular administration of either agent elicited convulsant activity in mice. This convulsant effect can be antagonized by pretreating the mice with n-dipropylacetate (valproate). Our results suggest that cis-1 may act indirectly as a partial gamma-aminobutyric acid (GABA) agonist in vivo. On the other hand, both cis-1 and 2, at higher concentrations, exhibit properties of a GABA-antagonist, but this effect seems not to be due to GABA receptor binding.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects; D003292:Convulsants; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010852:Picrotoxin / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014635:Valproic Acid / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D001058:Apomorphine; D003292:Convulsants; D010852:Picrotoxin; D011804:Quinolines; D014635:Valproic Acid; D005680:gamma-Aminobutyric Acid; C037920:decahydroquinoline-5-carboxylic acid