The renal origin of sodium valproate-induced hyperammonemia in fasting humans.
Acute administration of 1,500 mg of sodium valproate or chronic administration of 30 mg/kg/24 hours induced a more than twofold increase of renal ammoniagenesis in fasting subjects. Hyperammonemia was moderate, as normal hepatic ammonia detoxification persisted. Renal uptake of glutamine increased simultaneously.
D000328:Adult; D000641:Ammonia / Q000097:blood* / Q000378:metabolism; D005215:Fasting; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D014635:Valproic Acid / Q000494:pharmacology*
D014635:Valproic Acid; D000641:Ammonia