Seizures associated with high maprotiline serum concentrations.
Maprotiline is a tetracyclic antidepressant which appears to have accounted for a relatively large proportion of the seizures associated with antidepressant use. The literature proposes two mechanisms of seizure induction: interaction with other medications and concomitant medical conditions lowering the seizure threshold. Observations during a study of maprotiline blood levels suggest that elevated serum concentrations achieved with therapeutic doses may also be linked to the seizure-induction mechanism. Monitoring of maprotiline blood levels may help to identify patients at risk.
D000328:Adult; D000873:Anthracenes / Q000009:adverse effects*; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004830:Epilepsy, Tonic-Clonic / Q000097:blood / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male; D008376:Maprotiline / Q000009:adverse effects* / Q000097:blood
D000873:Anthracenes; D008376:Maprotiline