Intrastromal crystalline deposits following corneal graft rejection.
Five patients were noted to develop fine crystals in the corneal stroma following rejection of corneal grafts. Four had penetrating, and one lamellar, keratoplasty. All recovered from rejection after steroid therapy. The crystals were fine, gray to tan, refractile, not associated with visual loss, and stable over several months of follow-up. We speculate that these crystals may be related to immune globulin or immune complex deposition, although they may be lipid left after resolution of inflammatory infiltrate.
D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D003315:Cornea / Q000187:drug effects / Q000378:metabolism; D016039:Corneal Transplantation; D003460:Crystallization; D005260:Female; D006084:Graft Rejection / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011239:Prednisolone; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D011239:Prednisolone