Antianaphylactic effect of naloxone in mice is mediated by increased central sympathetic outflow to sympathetic nerve endings and adrenal medulla.
Intravenous naloxone, 1 or 10 mg/kg, protects sensitized mice from lethal anaphylaxis. The protective effect is reversed by pretreatment with the ganglionic blocker, chlorisondamine chloride, peripheral chemical sympathectomy with 6-hydroxydopamine or bilateral adrenal gland denervation. The possible involvement of the sympathetic nervous system in naloxone's antianaphylactic action, suggested by these findings, is discussed.
D000313:Adrenal Medulla / Q000294:innervation*; D000707:Anaphylaxis / Q000517:prevention & control*; D000818:Animals; D002714:Chlorisondamine / Q000494:pharmacology; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D051379:Mice; D009270:Naloxone / Q000494:pharmacology*; D016627:Oxidopamine; D013564:Sympathetic Nervous System / Q000187:drug effects*
D006892:Hydroxydopamines; D009270:Naloxone; D016627:Oxidopamine; D002714:Chlorisondamine