Non-specific immunity to Plasmodium falciparum: in vitro studies.
Peripheral blood mononuclear cells (PBM) were cultured with Plasmodium falciparum malaria for several cycles of parasite growth. Non-immune PBM inhibited P. falciparum more frequently than immune PBM. The inhibiting factor appears to be released during the first 24 hours of culture and is a non-dialysable factor, probably originating from monocytes. The relevance of these findings to in vivo immunity is discussed.
D002474:Cell-Free System; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007113:Immunity, Innate; D007958:Leukocyte Count; D007962:Leukocytes / Q000276:immunology; D008288:Malaria / Q000276:immunology*; D009000:Monocytes / Q000276:immunology; D010963:Plasmodium falciparum / Q000254:growth & development / Q000276:immunology