The precipitating antibody to an acidic nuclear protein antigen, the Jo-1, in connective tissue diseases. A marker for a subset of polymyositis with interstitial pulmonary fibrosis.
The clinical significance of antibodies to the Jo-1 antigen in connective tissue diseases was studied. Clinical diagnoses of 11 patients who had anti-Jo-1 antibody were: polymyositis 8, dermatomyositis 1, and overlap syndrome 2 (polymyositis--systemic lupus erythematosus 1, polymyositis--scleroderma 1). All the patients who had anti-Jo-1 antibody showed interstitial pulmonary fibrosis, and in 2 patients anti-Jo-1 antibodies were detected before the appearance of lung disease.
D000328:Adult; D000974:Antibodies, Antinuclear / Q000276:immunology*; D000918:Antibody Specificity; D001323:Autoantibodies / Q000032:analysis*; D003240:Connective Tissue Diseases / Q000276:immunology*; D003402:Creatine Kinase / Q000097:blood; D003882:Dermatomyositis / Q000276:immunology; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000150:complications / Q000276:immunology; D011658:Pulmonary Fibrosis / Q000150:complications / Q000276:immunology
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D003402:Creatine Kinase