Possible role of pituitary in Mitomycin C induced inhibition of testicular steroidogenesis.
To find out the role of pituitary in Mitomycin C (MC) induced reduction of testicular steroidogenesis, MC was administered along with HCG and the testicular steroidogenic activity was assessed on the basis of different parameters which are directly and indirectly related to the rate of testicular steroid biogenesis. The results indicate that MC induced reduction in testicular steroidogenesis is not only due to its direct effect but suppression of pituitary gonadotrophin secretion may be one of the responsible factor.
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D006063:Chorionic Gonadotropin / Q000502:physiology; D004247:DNA / Q000378:metabolism; D003864:Depression, Chemical; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006651:Histocytochemistry; D008297:Male; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology*; D010902:Pituitary Gland / Q000502:physiology*; D051381:Rats; D013256:Steroids / Q000096:biosynthesis*; D013737:Testis / Q000201:enzymology / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D008937:Mitomycins; D013256:Steroids; D016685:Mitomycin; D004247:DNA; D002784:Cholesterol; D015096:3-Hydroxysteroid Dehydrogenases; D005954:Glucosephosphate Dehydrogenase; D001205:Ascorbic Acid