[Effect of chlorpromazine on pituitary concentrations of gonadotropins and prolactin in the pregnant rat].
Pituitary gonadotropins and prolactin were measured from day 1 (G1) to day 4 (G4) of gestation in control or chlorpromazine injected rats (Img/100 g body weight every 8 hours during 72 hours). Chlorpromazine induced a modification of pituitary gonadotropins and prolactin (decrease in LH from G1 to G4; decrease in FSH from G1 to G3; increase in PRL from G1 to G4). Differed implantation by chlorpromazine seemed to be due to a decrease in pituitary gonadotropins and an increase in pituitary prolactin.
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006062:Gonadotropins / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000378:metabolism; D010902:Pituitary Gland / Q000187:drug effects* / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D006062:Gonadotropins; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002746:Chlorpromazine
Action de la chlorpromazine sur les concentrations hypophysaires en gonadotropines et en prolactine de la ratte gestante.