[Capillary isotachophoresis--a new method in drug analysis. 1. Analytic capillary isotachophoresis of the peptide drugs saralasin, gonadorelin and protirelin].
Capillary isotachophoresis is presented as an electrokinetic separation and determination method with a wide field of application. Its efficiency meets standards applied to modern chromatographic techniques. The high separation efficiency of capillary isotachophoresis and the double system of detection, that yields two qualitative and quantitative data for each charge carrier zone, allow to consider capillary isotachophoresis to be very suitable for drug analysis. By the example of the peptides saralasin, gonadorelin and protirelin and the corresponding dosage forms, the suitability of the technique for identification, purity and stability tests, as well as for analytical work, is demonstrated. Special aspects of peptide evaluation, especially with regard to the characterization of standard substances, are dealt with.
D000085:Acetates / Q000032:analysis; D000804:Angiotensin II / Q000031:analogs & derivatives*; D004563:Electrochemistry; D004586:Electrophoresis / Q000379:methods; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis*; D010455:Peptides / Q000032:analysis; D012504:Saralasin / Q000032:analysis*; D012996:Solutions / Q000032:analysis; D013973:Thyrotropin-Releasing Hormone / Q000032:analysis*
D000085:Acetates; D010455:Peptides; D012996:Solutions; D000804:Angiotensin II; D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D012504:Saralasin
Die Kapillarisotachophorese--eine neue Methode in der Arzneimittelanalytik. 1. Mitteilung: Analytische Kapillarisotachophorese der Peptidarzneimittel Saralasin, Gonadorelin und Protirelin.