An hypothesis on the role of pteroylpolyglutamate derivatives as coenzymes.
Evidence is assembled supporting the view that the poly-gamma-Glu chain of pteroyl poly-gamma-Glu derivatives plays a role in coordinating the activities of enzymes involved in the sequential metabolism of single carbon units.
D003067:Coenzymes; D005492:Folic Acid / Q000031:analogs & derivatives*; D007700:Kinetics; D007780:Lacticaseibacillus casei / Q000201:enzymology; D008780:Methyltransferases / Q000378:metabolism*; D011485:Protein Binding; D011624:Pteroylpolyglutamic Acids / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013940:Thymidylate Synthase / Q000378:metabolism*
D003067:Coenzymes; D011624:Pteroylpolyglutamic Acids; D005492:Folic Acid; D008780:Methyltransferases; D013940:Thymidylate Synthase