[Changes in the spectrum of LDH isoenzymes in foci of epileptic activity induced by penicillin in the cerebral cortex of rats].
The correlation between electrophysiological changes and isozymes of LDH of the rat brain cortex was studied in seizure foci induced by application of sodium penicillin. It was discovered that activity of LDH1 was suppressed, and that of LDH5 fraction was elevated in the determinant focus, which indicates the enhanced glucose anaerobic transformation. The spectrum of LDH isozymes did not practically differ from the indicators in control animals in a homotopic region of the contralateral hemisphere prior to creation of the mirror focus. The anaerobic processes were found to be increased in the mirror focus and in the determinant one as well. Similar pattern of changes in electrophysiological and neurochemical characteristics in the determinant and dependent mirror foci attests to the formation of a pathological system out of the two epileptic foci.
D000818:Animals; D004828:Epilepsies, Partial / Q000139:chemically induced / Q000201:enzymology; D005260:Female; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008297:Male; D010406:Penicillins / Q000494:pharmacology*; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000201:enzymology*; D013003:Somatosensory Cortex / Q000187:drug effects / Q000201:enzymology*
D007527:Isoenzymes; D010406:Penicillins; D007770:L-Lactate Dehydrogenase
Izmeneiia spektra izofermentov LDG v ochagakh épilepticheskoĭ aktivnosti, vyzvannykh penitsillinom v kore golovnogo mozga krys.