Pharmacokinetics of 14C CDP-choline.
The absorption, metabolism and excretion of cytidine diphosphate choline (CDP-choline, citicoline, Somazina) were investigated in six adult healthy subjects after a single oral dose of 300 mg of the 14C-labelled compound. The compound was well tolerated by the subjects. Absorption was virtually complete with less than 1% of the dose being found in the faeces during the 5-day collection period. Two peaks were found in the plasma radioactivity time profile: the first at 1 h, and a second larger peak at 24 h post-dose. Elimination of the ingested dose occurred via respiratory CO2 and through urinary excretion; the former predominating, and both routes exhibited biphasic patterns characterized by an early phase followed by slower decline. It is postulated that in the healthy human subject CDP-choline is metabolized in the gut wall and in the liver; the products arising from the compound's extensive hepatic metabolism being subsequently available for diverse biosynthetic pathways, tissue metabolism, and excretion.
D000328:Adult; D001944:Breath Tests; D002245:Carbon Dioxide; D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000009:adverse effects / Q000378:metabolism*; D004032:Diet; D005243:Feces / Q000032:analysis; D006801:Humans; D007700:Kinetics; D008297:Male; D013997:Time Factors
D002245:Carbon Dioxide; D003566:Cytidine Diphosphate Choline; D002794:Choline