[Effect of ionophores A 23187 and valinomycin on acetyocholinesterase activity in rabbit erythrocytes].
Activity of cholinesterase was higher in young erythrocytes when the cell populations of various age were studied; the enzymatic activity was increased after addition of valinomycine into a medium independently on the antibiotic concentration and the enzyme activation was more pronounced in the old population of erythrocytes. The same alterations were observed in presence of calcium ionophore A 23187 and nystatin. Alterations in the enzymatic activity appear to depend on changes of erythrocyte membrane properties in ageing as well as on introduction of ionophore into the membrane.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001692:Biological Transport; D000001:Calcimycin / Q000494:pharmacology*; D004905:Erythrocyte Aging; D004910:Erythrocyte Membrane / Q000378:metabolism; D004912:Erythrocytes / Q000201:enzymology*; D007476:Ionophores / Q000097:blood; D007700:Kinetics; D009761:Nystatin / Q000494:pharmacology; D011817:Rabbits; D014634:Valinomycin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D007476:Ionophores; D009761:Nystatin; D014634:Valinomycin; D000001:Calcimycin
Vliianie ionofora A23187 i valinomitsina na aktivnost' atsetilkholinésterazy éritrotsitov krolika.