Further studies on sister-chromatid exchange frequency in users of hormonal contraceptives.
Women using an estrogen-progestogen combination contraceptive exhibited an increased frequency of sister-chromatid exchange (SCE), supporting our previous observation. These elevated SCE frequencies tended to decline 3 months after the discontinuation of the pill. Women using a progestogen injectable contraceptive, on the other hand, had unaltered SCE rates. The analysis, in vitro; of mitomycin-C-induced SCE frequencies in women using either the combination or the progestogen injectable contraceptives showed significantly higher rates of induced SCE.
D003271:Contraceptive Agents, Female / Q000494:pharmacology*; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D009640:Norethindrone / Q000494:pharmacology; D009644:Norgestrel / Q000494:pharmacology; D011247:Pregnancy; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D003271:Contraceptive Agents, Female; D003277:Contraceptives, Oral, Combined; D008937:Mitomycins; D009644:Norgestrel; D004997:Ethinyl Estradiol; D016685:Mitomycin; D009640:Norethindrone