Effect of insulin treatment on long-term diabetes-induced alteration of myocardial function.
Six months following the induction of diabetes by streptozotocin (50 mg/kg i.v.) diabetic rats exhibited elevated levels of plasma glucose and glycosylated hemoglobin. Plasma insulin levels were 50% of control and diabetic animals weighed significantly less than control. Using a working heart preparation it was found that (+) and (-) dP/dt and left ventricular pressure development (LVDP) was decreased in hearts from diabetic animals. Insulin treatment (9 U/kg/day s.c. of protamine zinc insulin) for 4 weeks prior to sacrifice restored body weight and plasma insulin to normal. Plasma glucose and glycosylated hemoglobin levels were significantly decreased towards normal in insulin treated diabetic rats. LVDP and (+) dP/dt was also partially returned to normal in insulin treated diabetic rats while (-) dP/dt was completely reversed to normal. Thus, 4 weeks of insulin treatment to rats previously diabetic for 5 months partially or totally reversed the changes produced by diabetes.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D007328:Insulin / Q000097:blood; D049528:Insulin, Long-Acting / Q000494:pharmacology / Q000627:therapeutic use*; D009200:Myocardial Contraction / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D007328:Insulin; D049528:Insulin, Long-Acting