Hydroperoxyeicosatetraenoic acids. Potent inhibitors of lymphocyte responses.
Arachidonic acid can be transformed into a series of HPETEs by the lipoxygenase enzyme activity of mouse peritoneal macrophages. These resulting HPETEs inhibit some mouse lymphocyte responses. When mice are injected with 15-L-HPETE, their splenocytes show a decreased [3H]thymidine uptake after lectin stimulation.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D037102:Lectins / Q000494:pharmacology; D015289:Leukotrienes; D008054:Lipid Peroxides; D008084:Lipoxygenase / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000187:drug effects; D013936:Thymidine / Q000378:metabolism
D001095:Arachidonic Acids; D037102:Lectins; D015289:Leukotrienes; D008054:Lipid Peroxides; C025086:15-hydroperoxy-5,8,11,13-eicosatetraenoic acid; D008084:Lipoxygenase; D013936:Thymidine