Evidence for a possible role of prostaglandins in implantation in rats.
Indomethacin (IM), a potent inhibitor of prostaglandin synthetase, significantly inhibited implantation in rats when administered at a single subcutaneous dose of 15 mg/kg on day 2 or 3 of pregnancy or at a dose of 800 micrograms administered intraluminally in the uterus on day 4 of pregnancy. Indomethacin, administered subcutaneously at a dose of 6 mg/kg on day 3 or 4 of pregnancy and intraluminally at a dose of 800 micrograms/rat on day 4 of pregnancy, also significantly reduced uterine prostaglandin levels. It is suggested that a certain level of uterine prostaglandins is essential for normal implantation and that indomethacin inhibits implantation by reducing uterine prostaglandin levels.
D000818:Animals; D016861:Cyclooxygenase Inhibitors; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D011247:Pregnancy; D011453:Prostaglandins / Q000502:physiology*; D011458:Prostaglandins E / Q000502:physiology; D011460:Prostaglandins F / Q000502:physiology; D051381:Rats; D014599:Uterus / Q000378:metabolism
D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D007213:Indomethacin