Sister-chromatid exchanges induced in swine lymphocytes by chronic oral doses of dimethylbenzanthracene.
Sister-chromatid exchanges were scored at 3-week intervals in lymphocytes of female swine ingesting daily doses of 1.25 or 2.50 mg/kg of 7,12-dimethylbenzanthracene (DMBA) for 160 days. Exchanges increased with time for about 120 days then reached a plateau at approximately 2.5 times their pretreatment level. No increase in chromosome aberrations could be identified as resulting from ingestion of the chemical. Week-old progeny of animals that had ingested the chemical throughout pregnancy showed no increase of exchanges in their peripheral lymphocytes.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000008:administration & dosage / Q000494:pharmacology*; D000284:Administration, Oral; D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D003434:Crossing Over, Genetic / Q000187:drug effects*; D005260:Female; D008214:Lymphocytes / Q000187:drug effects*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013552:Swine; D013556:Swine, Miniature
D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene