[Experimental studies on toxemia of pregnancy: relationship between sodium chloride and hypertension in pregnancy].
In the present studies, spontaneously hypertensive rats (SHR) were used as the experimental model of hypertension in pregnancy. Systolic blood pressure of the NaCl loading group was maintained in a hypertensive state throughout pregnancy, probably because of NaCl retention, whereas that of the control group fell in the last stage of gestation. Urinary kallikrein levels, prostaglandin F2 alpha main urinary metabolite (PGF-MUM), plasma renin activity and plasma aldosterone concentration were determined both in the control group and the NaCl loading group. The results suggested that the NaCl loading group successfully preserved negative feed back in the kallikrein-kinin system, prostaglandin system and renin-angiotensin-aldosterone system as the blood pressure regulation mechanism. Fetal prognosis was poor in the NaCl loading group, because the incidence of SFD and fetal death rate were significantly higher than those of the control group. These findings, including histological observations, were similar to those of hypertensive pregnancy in human subjects reported in recent studies, and suggested that NaCl was closely related to hypertension in pregnancy.
D000818:Animals; D001794:Blood Pressure; D004039:Diet, Sodium-Restricted; D015237:Dinoprost; D004573:Electrolytes / Q000652:urine; D005260:Female; D006973:Hypertension / Q000503:physiopathology*; D007610:Kallikreins / Q000652:urine; D011225:Pre-Eclampsia / Q000209:etiology / Q000503:physiopathology*; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology*; D011460:Prostaglandins F / Q000652:urine; D051381:Rats; D011918:Rats, Inbred SHR; D012083:Renin / Q000097:blood; D012965:Sodium Chloride / Q000494:pharmacology*
D004573:Electrolytes; D011460:Prostaglandins F; D012965:Sodium Chloride; D015237:Dinoprost; D007610:Kallikreins; D012083:Renin