Testicular damage after radioactive iodine (I-131) therapy for thyroid cancer.
Testicular damage was evaluated in twelve men by determination of sperm counts, serum FSH, LH, and testosterone up to 3 1/2 years after treatment with radioactive iodine (131I) therapy for thyroid cancer. Dose-dependent spermatogenic damage with elevation of serum FSH was evident. Full recovery in one and partial recovery in another patient was documented during 2 1/2 years of follow-up. Serial study in two patients documented a small but significant effect of 50 mCi 131I on serum FSH levels and clinically important effects appear to be restricted to men having multiple doses totalling over 100 mCi.
D000328:Adult; D000368:Aged; D004307:Dose-Response Relationship, Radiation; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects* / Q000627:therapeutic use; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects*; D013076:Sperm Count; D013091:Spermatogenesis / Q000528:radiation effects*; D013737:Testis / Q000528:radiation effects*; D013739:Testosterone / Q000097:blood; D013964:Thyroid Neoplasms / Q000532:radiotherapy*; D013997:Time Factors
D007457:Iodine Radioisotopes; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone