[Determination of the optimal L-thyroxine dosage for treating nontoxic goiter].
303 patients with non-toxic goitre (aged 14-85 years) were studied to determine the extent to which the level of thyroid-hormone dosage until a negative TRH test is reached can be defined in terms of age, body surface area and goitre size. In all instances detailed examination had determined regular hormone intake. The required L-thyroxine dose (until negative TRH test) was 100 micrograms/d in 75.6% of cases, 125 micrograms/d in 9.2% and 150 micrograms/d in 8.6% of cases. In 2.6% of cases was a satisfactory suppression reached at 50 microgram/d and in 4% at 75 micrograms/d. There was no correlation of the level of L-thyroxine dose to body surface area, age, T3 level, delta-TSH or goitre size. There was a slight correlation between T4 level and optimal L-thyroxine dose, but not significant because of the wide range of normal. The results indicate that the only way to obtain optimal L-thyroxine dosage in the treatment of goitre is by doing a TRH test in the given patient.
D000293:Adolescent; D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D005260:Female; D006042:Goiter / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000008:administration & dosage* / Q000097:blood; D013997:Time Factors; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D013974:Thyroxine
Ermittlung der optimalen L-Thyroxin-Dosis zur Behandlung der blanden Struma.