Possible molecular detent in the DNA structure at regulatory sequences.
A common feature that appears in a number of DNA sites where proteins interact is the sequence GTG/CAC. In the lac operator this sequence leads to a region with a higher imino proton exchange rate well below the optical melting temperature. It is suggested that this reflects a structural feature recognized by proteins that bind specific sites on the DNA molecule.
D001483:Base Sequence; D001665:Binding Sites; D004247:DNA; D004926:Escherichia coli / Q000235:genetics; D007763:Lac Operon; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009690:Nucleic Acid Conformation; D012045:Regulatory Sequences, Nucleic Acid; D012097:Repressor Proteins
D012097:Repressor Proteins; D004247:DNA