Hyposensitisation to wasp venom in six hours.
Eleven patients with a history of anaphylaxis, positive reactions to skin tests, and specific IgE antibody to wasp venom underwent hyposensitisation in a six hour procedure. No general reactions occurred. Complement activation and proteinuria could not be shown. The patterns of specific IgE, IgG1, and IgG4 were as described in other procedures--namely, IgE increased sharply and then decreased; IgG1 and IgG4 increased steadily and then decreased--but increase and decrease came earlier. Challenge by a stinging insect at least four weeks after treatment proved complete protection. The skin reactivity two years later showed an unpredictable pattern.
D000328:Adult; D000707:Anaphylaxis / Q000517:prevention & control; D001514:Bee Venoms / Q000276:immunology*; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014862:Wasp Venoms / Q000276:immunology*
D001514:Bee Venoms; D007075:Immunoglobulin M; D014862:Wasp Venoms; D007073:Immunoglobulin E