Prevalence of a non-A, non-B-associated antigen/antibody system detected by radioimmunoassay in acute and chronic liver disease.
An antigen/antibody system associated with one form of parenterally transmitted non-A, non-B (NANB) hepatitis has been identified by solid-phase radioimmunoassay (RIA). The antigen is found in 3% of normal subjects and in increased frequency in patients with haemophilia, renal homograft recipients, homosexual men, prostitutes, drug addicts, and patients with chronic hepatitis B virus (HBV) infection. The antigen was found in normal frequency in patients with acute hepatitis A and B, sporadic NANB hepatitis (nondrug addicts), autoimmune and alcohol-induced chronic liver disease, and primary biliary cirrhosis.
D000208:Acute Disease; D000914:Antibodies, Viral / Q000032:analysis*; D000956:Antigens, Viral / Q000032:analysis*; D001782:Blood Donors; D002908:Chronic Disease; D005164:Factor IX / Q000008:administration & dosage; D006506:Hepatitis A / Q000276:immunology; D006509:Hepatitis B / Q000276:immunology; D006526:Hepatitis C / Q000276:immunology*; D006518:Hepatitis Viruses / Q000276:immunology*; D006525:Hepatitis, Viral, Human / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation; D008107:Liver Diseases / Q000276:immunology*; D011863:Radioimmunoassay; D006435:Renal Dialysis; D019966:Substance-Related Disorders
D000914:Antibodies, Viral; D000956:Antigens, Viral; D005164:Factor IX