Evidence for early fluidity changes in the plasma membranes of interferon treated L cells, from fluorescence anisotropy data.
A significant increase of the plasma membrane fluidity is observed in L cells upon treatment with mouse beta interferon, by the means of fluorescence anisotropy measurements of DPH. The effect is dose dependent and, at the difference with previously reported membrane effects of interferon, is an early one (maximum for a 30 min. treatment), and may be directly related to the initiation of antiviral activity.
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D005454:Fluorescence Polarization; D007371:Interferon-gamma / Q000494:pharmacology*; D007700:Kinetics; D007739:L Cells / Q000187:drug effects / Q000378:metabolism; D008560:Membrane Fluidity / Q000187:drug effects*; D051379:Mice
D007371:Interferon-gamma