De novo development of hypercholesterolaemia and increased HDL-cholesterol: apoprotein A-I ratio in patients with chronic renal failure following kidney transplantation.
Lipid profiles were studied in 27 kidney transplant patients with stable renal function during long term follow-up and 18 haemodialysis patients. Hypertriglyceridaemia resolved after kidney transplantation. In contrast, hypercholesterolaemia developed and persisted in transplant patients. HDL-CHL temporarily elevated at 1-5 years post-transplant compared to decreased values during haemodialysis. HDL-CHL:Apo . A-I ratio became elevated post-transplant, although no variation in Apo . A-I values was observed between either groups. It is suggested that qualitative and quantitative changes of HDL particles develop after grafting.
D000328:Adult; D016632:Apolipoprotein A-I; D001053:Apolipoproteins / Q000097:blood*; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology*; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D016030:Kidney Transplantation; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D006435:Renal Dialysis; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D014280:Triglycerides; D002784:Cholesterol