Quantification of large C3 fragments as an index of complement activation in mice. II. In vivo studies.
A method which enables to evaluate the mouse C3 activation has been used to study the activation of the complement system in C57Bl/6 mice injected with cobra venom factor, with Escherichia coli, and with bacterial lipopolysaccharide. It was found that this method was able to detect the complement activation early, at a time when total levels of C3-reacting molecules had not yet decreased.
D000818:Animals; D003167:Complement Activation; D003176:Complement C3 / Q000032:analysis* / Q000378:metabolism; D004546:Elapid Venoms / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D007700:Kinetics; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL
D003176:Complement C3; D004546:Elapid Venoms; D008070:Lipopolysaccharides; C016310:cobra venom factor