Sequential ventricular fluid concentrations of ceftazidime--report of three cases.
Three adult subjects, each with a ventriculostomy, received ceftazidime 2g iv q8h for three doses. Serial samples of serum and CSF ventricular fluid were obtained following the third dose; ceftazidime concentrations were measured by high pressure liquid chromatography. In one patient without inflammatory cells in the CSF, ceftazidime CSF concentrations were only approximately 0.3 micrograms/ml. In two other patients who had inflammatory cells and blood in the CSF, concentrations of ceftazidime in ventricular fluid demonstrated a slow rise and decline over an eight-hour period. Although contamination of the CSF by blood in these two patients confounds the interpretation of the concentrations achieved, it is concluded that obtaining serial samples of CSF from a ventriculostomy offers a more realistic appraisal of the dynamics of antibiotic penetration compared with the single-point method.
D000328:Adult; D000368:Aged; D001812:Blood-Brain Barrier / Q000187:drug effects; D002442:Ceftazidime / Q000097:blood / Q000134:cerebrospinal fluid*; D002552:Cerebral Ventricles / Q000378:metabolism* / Q000601:surgery; D005260:Female; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D013997:Time Factors
D002442:Ceftazidime