[Effect of different doses of dichlorodiphenyl on the cytochrome P-450 level and lipid peroxidation rate in the rat liver].
A single administration of increasing doses of dichlorodiphenyl (60-2400 mg/kg) leads to an increase in the content of cytochrome P-450 in rat liver. Initially, the increase rate is high whereupon, within the dose ranges of 800-1600 mg/kg, it does not virtually change, constituting 270-290%. A higher dose, 2400 mg/kg, produces an increase in the hemoprotein level only in individual animals. When given in cytochrome P-450-induction doses, dichlorodiphenyl has a stimulant action on the non-enzymatic system of lipid peroxidation in rat liver.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D011078:Polychlorinated Biphenyls / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D008054:Lipid Peroxides; D003577:Cytochrome P-450 Enzyme System; D011078:Polychlorinated Biphenyls
Izuchenie vliianiia razlichnykh doz dikhlordifenila na uroven' tsitokhroma P-450 i skorost' perekisnogo okisleniia lipidov v pecheni krys.