[Continuous subcutaneous insulin infusion: long-term treatment in an unselected group of insulin-dependent diabetics].
Long-term ambulatory continuous subcutaneous insulin infusion was undertaken under serial blood-glucose control in nine insulin-dependent diabetics. Before this treatment was started, haemoglobin A1 was increased (more than 13%), diabetic lipoid necrosis was present in three, proliferative diabetic retinopathy in one, treatment-resistant Candida oesophagitis in one and Addison's disease in one. During the total of 630 weeks (range 6-135 weeks) of continuous subcutaneous insulin infusion it was found that (1) the metabolic state of the patients improved significantly, the previously non-responding oesophagitis healed and one of three patients with diabetic lipoid necrosis was markedly improved; (2) the risks of insulin treatment, hypoglycaemia (especially with Addison's disease) and keto-acidosis (for technical reasons) remained; and (3) in long-standing diabetes of type I even good control of blood glucose levels (mean 113 mg/dl) could neither prevent the occurrence of proliferative diabetic retinopathy nor loss of sight.
D000328:Adult; D000553:Ambulatory Care; D001766:Blindness / Q000517:prevention & control; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy*; D016883:Diabetic Ketoacidosis / Q000209:etiology; D003930:Diabetic Retinopathy / Q000517:prevention & control; D004868:Equipment Failure; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000209:etiology; D007332:Insulin Infusion Systems; D008297:Male; D008875:Middle Aged
Kontinuierliche subkutane Insulin-Infusion: Langzeitbehandlung bei einer unausgew+5Aahlten Gruppe insulinabhängiger Diabetiker.