Dog MHC class I antigens contain beta 2-microglobulin.
Detergent-solubilized DLA class I antigens have been isolated by immunoprecipitation from peripheral blood lymphocytes with an anti-beta 2-microglobulin serum and an alloantiserum. Amino acid composition and NH2-terminal amino acid sequence analysis confirmed that the DLA light chain is identical to dog urinary beta 2-microglobulin, and that the DLA heavy chain shows homology to the major histocompatibility complex class I heavy chains of other species.
D000595:Amino Acid Sequence; D000818:Animals; D004285:Dogs / Q000235:genetics / Q000276:immunology*; D006649:Histocompatibility Antigens / Q000235:genetics*; D015395:Histocompatibility Antigens Class I; D008969:Molecular Sequence Data; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity; D001613:beta 2-Microglobulin / Q000235:genetics*
D006649:Histocompatibility Antigens; D015395:Histocompatibility Antigens Class I; D001613:beta 2-Microglobulin; C039692:histocompatibility antigen DLA