[Drug sensitivity of Plasmodium falciparum in Madagascar. V. Study of the in vitro activity of quinine, mefloquine and halofantrine].
In a nine month fields study in 1983 in Madagascar, in vitro sensitivity to others drugs than 4 aminoquinolines were tested for 39 Plasmodium falciparum isolates, including 2 chloroquine resistant ones. Sensitivity to quinine, mefloquine and halofantrine were recorded from 28, 39 and 11 of these isolates respectively. IC50 with semi-microtest were under 20 nM/1 for mefloquine, under 12 nM/1 for halofantrine and under 560 nM/1 for quinine. All these values are under maximal values observed elsewhere with isolates coming from patients successfully treated with the three drugs.
D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D006801:Humans; D015767:Mefloquine; D008826:Microbial Sensitivity Tests; D010616:Phenanthrenes / Q000494:pharmacology*; D010963:Plasmodium falciparum / Q000187:drug effects*; D011803:Quinine / Q000494:pharmacology*; D011804:Quinolines / Q000494:pharmacology*
D000962:Antimalarials; D010616:Phenanthrenes; D011804:Quinolines; D002738:Chloroquine; D011803:Quinine; C023768:halofantrine; D015767:Mefloquine
Pharmacosensibilite de Plasmodium falciparum a Madagascar. V. Etude del'activite in vitro de la quinine, de la mefloquine et de l'halofantrine.