Intravesical chemotherapy of urinary bladder tumor in rabbit by ferromagnetic mitomycin C.
Considering the necessity of selective toxicity in cancer chemotherapy, an advantageous means of controlling the anticancer agent in the urinary bladder was facilitated by microencapsulation of the drug and ferrite particles. Pharmacokinetic analysis of intravesical instillation chemotherapy in rabbits proved that magnetic control of ferromagnetic microencapsulated mitomycin C (MMC) remarkably enhanced MMC absorption into the urinary bladder wall. Moreover, malignant bladder tumors in rabbits were successfully treated with this method.
D000042:Absorption; D000818:Animals; D005290:Ferric Compounds / Q000008:administration & dosage*; D007501:Iron / Q000008:administration & dosage*; D008280:Magnetics; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage* / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011817:Rabbits; D001743:Urinary Bladder / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000378:metabolism
D005290:Ferric Compounds; D008937:Mitomycins; C001215:ferrite; D016685:Mitomycin; D007501:Iron