[In vivo interferon-inducing capacity of a multibacterial extract: prospective new use].
We studied IFN inducing ability on syngenic C3H mice of a multibacterial antigenic extract consisting of different strains of following species: Staphylococcus aureus, Escherichia coli, Aerobacter aerogenes, Proteus vulgaris. A dose-dependent IFN production was demonstrated and two peaks of circulating IFN were observed few hours and two days after i.v. inoculation. Per os administration only at high doses induced evaluable levels of IFN in the circulation.
D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage*; D004754:Enterobacter / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology; D007369:Interferon Inducers; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D011514:Proteus vulgaris / Q000276:immunology; D013211:Staphylococcus aureus / Q000276:immunology
D000942:Antigens, Bacterial; D007369:Interferon Inducers
Capacita' inducente interferon in vivo di un estratto multibatterico: una nuova prospettiva di impiego.