Comparative aspects of purine metabolism in some African trypanosomes.
Some enzymes of purine salvage were detected in the cell-free preparations from bloodstream forms of African trypanosomes: Trypanosoma vivax; T. brucei and T. congolense. Extracts of trypanosomes cleave adenosine and inosine hydrolytically except in T. congolense where adenosine cleavage was mediated by a phosphorylase. All the trypanosomes apparently lacked adenosine deaminase. Adenine aminohydrolase was found only in T. vivax while adenosine monophosphate deaminase was detected in T. brucei and T. congolense. There was no detectable adenosine kinase activity in T. brucei. A pathway is proposed for the metabolism of purines in these trypanosomes.
D000243:Adenosine Deaminase / Q000378:metabolism; D000248:Adenosine Kinase / Q000378:metabolism; D000619:Aminohydrolases / Q000378:metabolism; D000818:Animals; D009699:N-Glycosyl Hydrolases / Q000378:metabolism; D010430:Pentosyltransferases / Q000378:metabolism; D011683:Purine-Nucleoside Phosphorylase / Q000378:metabolism; D011687:Purines / Q000378:metabolism*; D014345:Trypanosoma / Q000378:metabolism*; D014346:Trypanosoma brucei brucei / Q000378:metabolism; D014348:Trypanosoma congolense / Q000378:metabolism
D011687:Purines; D010430:Pentosyltransferases; C022484:purine phosphoribosyltransferase; D011683:Purine-Nucleoside Phosphorylase; D000248:Adenosine Kinase; D009699:N-Glycosyl Hydrolases; C030681:purine nucleosidase; D000619:Aminohydrolases; C018774:adenine deaminase; D000243:Adenosine Deaminase