Effect of PGI2 on platelet aggregates in myocardial infarction evaluated in vitro in whole blood. The method for quantification of platelet aggregates.
PGI2 was found to increase the number of free platelets (FP) in citrated whole blood (WB) as a result of incomplete dispersion of platelet aggregates of various magnitudes. In WB from young, male volunteers the effect of PGI2 on FP number was absent immediately after blood collection, increased with time of blood storage, and was dose-dependent. In WB from 14 males with myocardial infarction (MI) effect of PGI2 on FP number was higher than in 11 male patient controls (PC). On 14th day after MI effect of PGI2 on FP in WB was reduced. It is concluded that measurement of PGI2-sensitive platelet aggregates may be of some clinical significance. However, presented results did not allow for differentiation between circulating platelet aggregates and those formed in vitro during spontaneous aggregation of platelets.
D011464:Epoprostenol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000503:physiopathology*; D010974:Platelet Aggregation / Q000187:drug effects*; D012016:Reference Values
D011464:Epoprostenol