Valproic acid and intractable seizures in severely brain-damaged patients.
We treated 52 mentally retarded patients with intractable seizures by adding valproic acid (VPA) to other drug regimens. Sixty-one percent improved clinically. VPA significantly reduced the frequency of generalized tonic-clonic seizures, generalized myoclonus, absence and atonic seizures. There was a significant correlation between clinical improvement and reduction of EEG paroxysmal activity.
D000293:Adolescent; D000328:Adult; D001925:Brain Damage, Chronic / Q000150:complications; D002648:Child; D004827:Epilepsy / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D014635:Valproic Acid / Q000008:administration & dosage*
D014635:Valproic Acid