[Modeling radiation damage to DNA using radionuclides incorporated into polynucleotides].
Because of a great variety and different reparability of radiation-induced DNA lesions it is difficult to evaluate the radiobiological significance of certain individual alterations. It is suggested that the radionuclides incorporated into DNA can be used to imitate different types of radiation damages to DNA. Both qualitative and quantitative aspects of the problem are discussed.
D004247:DNA / Q000528:radiation effects*; D004926:Escherichia coli / Q000528:radiation effects; D008954:Models, Biological; D009154:Mutation; D010761:Phosphorus Radioisotopes; D011685:Purine Nucleotides / Q000528:radiation effects; D011742:Pyrimidine Nucleotides / Q000528:radiation effects; D011831:Radiation Genetics; D011868:Radioisotopes; D012441:Saccharomyces cerevisiae / Q000528:radiation effects; D014316:Tritium
D010761:Phosphorus Radioisotopes; D011685:Purine Nucleotides; D011742:Pyrimidine Nucleotides; D011868:Radioisotopes; D014316:Tritium; D004247:DNA
Modelirovanie radiatsionnykh povrezhdeniĭ DNK pri pomoshchi deĭstviia vkliuchennykh v polinukleotidy radionuklidov.