Alternative RNA processing events as a critical developmental regulatory strategy in neuroendocrine gene expression.
Alternative RNA processing events, consequential to alternative poly(A) site selection, represent the critical developmental strategy dictating the tissue-specific pattern of the polypeptide product production in calcitonin gene expression. The consequence of these events is the production of an mRNA encoding the precursor of a novel neuropeptide, referred to as CGRP, in the brain and an mRNA encoding the precursor to calcitonin in the thyroidal C cells. A trans-acting mechanism appears to adjudicate the critical choice of poly(A) site. It is suggested that this type of RNA processing regulation is a commonly used mechanism, of particular importance in expression of genes modulating neural developmental events.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001923:Brain Chemistry; D002116:Calcitonin / Q000235:genetics*; D015740:Calcitonin Gene-Related Peptide; D004247:DNA; D005786:Gene Expression Regulation; D005796:Genes; D009479:Neuropeptides / Q000378:metabolism; D012323:RNA Processing, Post-Transcriptional; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D014158:Transcription, Genetic
D009479:Neuropeptides; D012333:RNA, Messenger; D002116:Calcitonin; D004247:DNA; D015740:Calcitonin Gene-Related Peptide