Pituitary function in 20 cases of prolactinoma in females.
Women with prolactinic pituitary tumor in the fertile period have increased (60-400 ng/ml) blood prolactin values and decreased LH and FSH as compared to healthy women of the same age. Among the mechanisms implied in prolactin hypersecretion in females with prolactinic tumor worth noting are: low receptivity to dopamine, low dopamine production, elevated serotonin and TRH production, stress factors. Suppression of prolactin secretion with bromcriptine induces a rise in LRH and consequently in LH and FSH. A drug treatment is suggested for prolactin hypersecretion in women with prolactinic pituitary tumor, consisting in association of small doses of bromcriptine, L-DOPA, metergolina and thyroxine, and avoidance of stressing circumstances.
D000328:Adult; D001971:Bromocriptine / Q000494:pharmacology; D005260:Female; D005934:Glucagon / Q000494:pharmacology; D006801:Humans; D007980:Levodopa / Q000494:pharmacology; D008711:Metergoline / Q000494:pharmacology; D010902:Pituitary Gland / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D008711:Metergoline; D001971:Bromocriptine; D007980:Levodopa; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D005934:Glucagon