Humoral immune response to some benzylpenicillin preparations.
In this study the humoral immune responses to long-term administration of benzylpenicillin preparations with and without adjuvants were compared. In 44.4% of the patients on long-term treatment with a benzylpenicillin preparation containing oil and alum monostearate, an induction of benzylpenicilloyl (BPO)-specific IgG, IgM and IgE was demonstrated during and after the course. Patients treated with a benzylpenicillin preparation containing no oil and alum monostearate showed only a very weak BPO-specific IgM and IgG response during the course. In patients in whom long-term treatment with a benzylpenicillin preparation without adjuvants was initiated by a benzylpenicillin preparation containing oil and alum monostearate, not only BPO-specific IgM and/or IgG but also IgE were demonstrated in 13.0%. The differences in immune response in the various long-term courses were significant (P less than 0.05). The data suggest that the presence of such adjuvants as oil and alum monostearate has an influence on the synthesis of BPO-specific antibodies. However, it can not be excluded that the difference in immunogenicity had some unknown connection with the differences in penicillin/blood levels.
D000918:Antibody Specificity; D044482:Benzeneacetamides; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000032:analysis / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000032:analysis / Q000096:biosynthesis; D007136:Immunoglobulins / Q000032:analysis / Q000096:biosynthesis*; D008134:Long-Term Care; D010400:Penicillin G / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000097:blood / Q000276:immunology*; D013587:Syphilis / Q000188:drug therapy / Q000276:immunology
D044482:Benzeneacetamides; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; C015026:benzylpenicilloyl G; D007073:Immunoglobulin E; D010400:Penicillin G