A new site for islet transplantation--a peritoneal-omental pouch.
A new site for islet transplantation is described. A peritoneal-omental pouch was constructed in diabetic rats by encasing the omentum in a pouch formed from a strip of parietal peritoneum obtained from the recipient. Isografts of rat islets placed in the pouch maintained normoglycemia in the recipients and removal of the pouch resulted in a rapid return to a diabetic state. This site may be applicable to the transplantation of islets in human diabetes.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000628:therapy; D016381:Islets of Langerhans Transplantation; D008297:Male; D009852:Omentum / Q000637:transplantation*; D010537:Peritoneum / Q000637:transplantation*; D051381:Rats; D011919:Rats, Inbred Strains; D014185:Transplantation, Isogeneic / Q000379:methods*