[Clinical, immunologic and electrophysiologic correlations in evaluating multiple sclerosis in relation to its development].
49 patients with multiple sclerosis (MS) were evaluated on several lines of investigation: clinical examination with disability rating scale, disease activity staging, multimodal evoked potentials and cerebrospinal fluid analysis. 24 patients were monthly re-examined and T-cell subsets were analysed in the peripheral blood. Evoked potentials were re-evaluated every 3 months in 24 patients. All paramethers were correlated in transversally and longitudinally during a 3 to 18 months follow-up. The results are discussed in the view of a methodological approach to a laboratory evaluation of disease evolution in its natural course and during therapeutic trials.
D000293:Adolescent; D000328:Adult; D002555:Cerebrospinal Fluid / Q000276:immunology; D002986:Clinical Trials as Topic; D004185:Disability Evaluation; D005073:Evoked Potentials, Somatosensory; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008297:Male; D009103:Multiple Sclerosis / Q000276:immunology* / Q000503:physiopathology / Q000628:therapy; D012008:Recurrence; D013601:T-Lymphocytes / Q000276:immunology
D007074:Immunoglobulin G
Correlazioni cliniche, immunologiche ed elettrofisiologiche nella valutazione della sclerosi multipla in rapporto all'evoluzione.