Pancreatic islet allograft prolongation by donor-specific blood transfusions treated with ultraviolet irradiation.
Survival of allografts of islets of Langerhans in nonimmunosuppressed adult rats was prolonged by transfusions of donor blood irradiated with ultraviolet light before transplantation across a major histocompatibility barrier. This treatment is donor blood-specific and has produced greater than 160-day survival of transplanted islets without the administration of immunosuppressive agents.
D000818:Animals; D001773:Blood Cells / Q000276:immunology / Q000528:radiation effects; D001803:Blood Transfusion; D006085:Graft Survival; D007165:Immunosuppression Therapy; D016381:Islets of Langerhans Transplantation; D051381:Rats; D014466:Ultraviolet Rays