Successful rat pancreatic islet allotransplantation without recipient immunosuppression.
Pancreatic islets from Wistar Furth (RT1u) rats are rejected by 5 days after transplantation into the liver of the diabetic Lewis (RT11) rat. Pretreatment of Wistar Furth islets by culture for 7-10 days in 95% O2 5% CO2 reduces immunogenicity permitting successful allotransplantation as defined by normal blood and 24-hr urinary glucose values.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D046508:Culture Techniques; D003921:Diabetes Mellitus, Experimental / Q000628:therapy; D006084:Graft Rejection; D007165:Immunosuppression Therapy; D016381:Islets of Langerhans Transplantation; D051381:Rats; D011917:Rats, Inbred Lew; D011920:Rats, Inbred WF
D001786:Blood Glucose