Conspicuous enterocytic binding pattern for peanut lectin and malignant histiocytosis of the intestine.
We present a case of a 33 year old male with a history of early childhood diarrhoea and more recently diagnosed gluten sensitive enteropathy, who died with active disease, ulcerative proctosigmoiditis and desquamative erythrodermia associated with toxin induced shock. Autopsy revealed a tumour restricted to lymph nodes of the mesentery and the retroperitoneum. This is considered to be malignant histiocytosis of the intestine (MIH). Immunohistological examination of the diagnostic jejunal biopsy showed a pathological binding pattern for peanut lectin (PNL) within the enterocytes. This may be an expression of disturbed production or secretion of a product rich in non-reducing terminal D-galactosyl residues.
D000328:Adult; D001344:Autopsy; D001665:Binding Sites; D001706:Biopsy; D002446:Celiac Disease / Q000150:complications* / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000032:analysis*; D007414:Intestinal Neoplasms / Q000150:complications* / Q000473:pathology; D037102:Lectins; D008206:Lymphatic Diseases / Q000150:complications* / Q000473:pathology; D008297:Male; D019887:Peanut Agglutinin
D037102:Lectins; D019887:Peanut Agglutinin