Opiate peptides control growth hormone through a cholinergic mechanism in man.
Opiate peptides are known to elevate circulating GH in man, and data in other animals suggest that acetylcholine may be involved. We have administered the long-acting met-enkephalin analogue DAMME to 6 normal males, and have shown that the resulting elevation in GH is blocked by the specific cholinergic antagonist, pirenzepine. It seems likely that a cholinergic mechanism may interact with opiate-induced changes in GH in man.
D000328:Adult; D001570:Benzodiazepinones / Q000494:pharmacology; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; D004723:Endorphins / Q000502:physiology*; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors / Q000494:pharmacology; D006065:Gonadotropins, Pituitary / Q000097:blood; D013006:Growth Hormone / Q000097:blood*; D013007:Growth Hormone-Releasing Hormone / Q000037:antagonists & inhibitors / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology; D010890:Pirenzepine; D011950:Receptors, Cholinergic / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood
D001570:Benzodiazepinones; D004723:Endorphins; D006065:Gonadotropins, Pituitary; D010276:Parasympatholytics; D011950:Receptors, Cholinergic; D010890:Pirenzepine; D004744:Enkephalin, Methionine; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; D013972:Thyrotropin; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone; D006854:Hydrocortisone