Reversion by vitamin K of aflatoxin B1 (AFB)-induced inhibition of oxygen uptake in three AFB-susceptible bacteria.
The effect of Vitamin K, on the inhibition of oxygen uptake in Bacillus brevis (2611), Bacillus megaterium (1368) and Flavobacterium aurantiacum by aflatoxin B1 (AFB) has been investigated. At 1.5 mM, vitamin K completely reversed oxygen inhibition by 10 micrograms/ml AFB in the three bacteria and by 50 micrograms/ml AFB in B. brevis, the most susceptible of the three bacteria to AFB. Vitamin K did not reverse the inhibitory effect of 100 micrograms/ml AFB in any of the three bacteria except B. megaterium, neither did 1.5 mM 2,4-dinitrophenol (DNP) reverse the inhibition at 10 micrograms/ml and 100 micrograms/ml levels of AFB in any of the three bacteria.
D019297:2,4-Dinitrophenol; D016604:Aflatoxin B1; D000348:Aflatoxins / Q000037:antagonists & inhibitors*; D001407:Bacillus / Q000187:drug effects; D001410:Bacillus megaterium / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects*; D004140:Dinitrophenols / Q000378:metabolism; D005417:Flavobacterium / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D014812:Vitamin K / Q000494:pharmacology*
D000348:Aflatoxins; D004140:Dinitrophenols; D014812:Vitamin K; D016604:Aflatoxin B1; D019297:2,4-Dinitrophenol