The presence of J chain in mesangial immune deposits of IgA nephropathy.
In order to identify polymeric IgA in the mesangial IgA deposits of 33 patients, the presence of J chains by a PAP method was investigated. In 9/27 cases of primary IgA nephropathy (PIgANP) and in 4/4 cases of Henoch-Schönlein glomerulonephritis (HSGN) J chains were absent. The remaining cases, two of them with IgA glomerulonephritis associated with alcoholic cirrhosis (ACIgAGN), were J-positive. The two groups, PIgANP J-positive and PIgANP J-negative, were compared according to clinical features. The only difference detected was the time length between the disease onset and the renal biopsy, being shorter in the negative group.
D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis*; D005260:Female; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000276:immunology*; D006801:Humans; D011695:IgA Vasculitis / Q000276:immunology*; D007124:Immunoenzyme Techniques; D007070:Immunoglobulin A / Q000032:analysis*; D007144:Immunoglobulin J-Chains / Q000032:analysis*; D007668:Kidney / Q000276:immunology*; D008297:Male
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007144:Immunoglobulin J-Chains