Stimulation of cyclo-oxygenase by lidocaine, a pro-lipoperoxidant.
Lidocaine, which was recently demonstrated to be a good pro-lipoperoxidant, was tested on in vitro PGs biosynthesis, and on arachidonate-induced arterial hypotension, in the rabbit. In the in vitro experiments, lidocaine alone was a poor stimulant of cyclo-oxygenase, but it enhanced significantly the cyclo-oxygenase activation of uric acid. In the rabbit, lidocaine lowered the i.v. arachidonate dose necessary to obtain a significant drop of blood pressure.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004789:Enzyme Activation / Q000187:drug effects; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D011453:Prostaglandins / Q000096:biosynthesis; D011817:Rabbits; D012669:Seminal Vesicles / Q000201:enzymology; D014527:Uric Acid / Q000494:pharmacology
D001095:Arachidonic Acids; D011453:Prostaglandins; D014527:Uric Acid; D016718:Arachidonic Acid; D008012:Lidocaine; D011451:Prostaglandin-Endoperoxide Synthases