Staphylococcal lysate fails to elicit nonspecific immune enhancement in a simulated surgical infection.
Staphylococcus aureus produces a delayed-type hypersensitivity reaction, which results in some degree of nonspecific immune enhancement. The authors chose to observe the effects of staphylococcal vaccine (staphage lysate) as a possible potentiator of nonspecific immunity. The experiments were performed in a well-known model simulating surgical infection. The experimental results do not support the previously proposed hypothesis that staphylococcal vaccine improves the immune response to a bacterial challenge.
D000818:Animals; D001770:Blood Bactericidal Activity; D007111:Immunity, Cellular; D007710:Klebsiella Infections / Q000517:prevention & control*; D007711:Klebsiella pneumoniae; D008297:Male; D051379:Mice; D013209:Staphylococcal Vaccines / Q000008:administration & dosage / Q000276:immunology*; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013997:Time Factors; D014611:Vaccination
D013209:Staphylococcal Vaccines