Cross-reactive transplantation antigens between UV-irradiated skin and UV-induced tumors.
The fate of ultraviolet (UV) light-induced tumors transplanted into syngeneic hosts bearing skin grafts from UV-irradiated donors was studied. Our results suggest that UV-irradiated skin and UV-induced tumors express common antigens. Further, these results may bear on the question of how subcarcinogenic doses of UV radiation can effect the generation of tumor antigen-specific T suppressor cells prior to the existence of UV-induced tumors. Specifically, normal C3Hf/HeJ mice were grafted with UV-irradiated, or normal skin and subsequently implanted with either regressor, progressor, or conversion type UV-induced tumors. Animals bearing UV skin grafts were: a) effectively immunized against conversion type tumors, b) exhibited no differences against regressor type tumors, and c) allowed progressor type tumors to grow at an accelerated rate.
D000818:Animals; D003429:Cross Reactions; D005260:Female; D006649:Histocompatibility Antigens / Q000276:immunology*; D051379:Mice; D008809:Mice, Inbred C3H; D009381:Neoplasms, Radiation-Induced / Q000276:immunology*; D012867:Skin / Q000276:immunology / Q000528:radiation effects*; D012878:Skin Neoplasms / Q000276:immunology*; D016038:Skin Transplantation; D014466:Ultraviolet Rays / Q000009:adverse effects*
D006649:Histocompatibility Antigens