Memory retention in old rats: improvement by orotic acid.
The effect of methylglucamine orotate (MGO) on learning and memory was investigated in 24-month-old rats using brightness discrimination in a Y-chamber and active avoidance in a shuttle box. In both learning procedures, an improvement of memory retention following 5-day MGO treatment (225 mg/kg per day) was observed. The retention of untreated old animals was significantly lower compared to 8-week-old rats. MGO treatment resulted in a significant improvement of retention in old rats, which nearly compensated for their memory deficit.
D000375:Aging; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D004192:Discrimination, Psychological / Q000187:drug effects; D008027:Light; D008297:Male; D008568:Memory / Q000187:drug effects*; D009963:Orotic Acid / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012153:Retention, Psychology / Q000187:drug effects*
D009963:Orotic Acid