High-performance liquid chromatographic determination of nitroglycerin in sublingual, sustained-release, and ointment dosage forms.
A rapid, precise, sensitive, and specific assay for nitroglycerin in sublingual, sustained-release, and ointment dosage forms using high-performance liquid chromatography is described. The nitroglycerin dosage forms were dissolved in methanol, filtered, and injected directly into the liquid chromatograph. A variable-wavelength UV detector operated at 220 nm and a C18 microporous silica column were employed. The mobile phase was methanol-water (40:60).
D002214:Capsules / Q000032:analysis; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003692:Delayed-Action Preparations / Q000032:analysis; D005996:Nitroglycerin / Q000032:analysis*; D009824:Ointments / Q000032:analysis; D013607:Tablets / Q000032:analysis
D002214:Capsules; D003692:Delayed-Action Preparations; D009824:Ointments; D013607:Tablets; D005996:Nitroglycerin