Effect of interferon on murine cytochrome P-450: effect of partially purified antigen-specific interferon-gamma.
Gamma interferon (IFN-gamma), induced by sensitization of mice with Mycobacterium bovis strain BCG followed by challenge with tuberculin, was partially purified by adsorption on silicic acid. Administration of the partially purified IFN-gamma to mice significantly depressed levels of liver microsomal cytochrome P-450 to an equivalent extent as crude IFN-gamma.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D007116:Immunization, Passive; D007371:Interferon-gamma / Q000302:isolation & purification / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D051379:Mice
D007371:Interferon-gamma; D003577:Cytochrome P-450 Enzyme System