C3 polymorphism in beta-thalassemia.
The distribution of phenotypes and gene frequencies of the third component of complement (C3) were studied in 106 beta-thalassemic patients and in 112 carriers of the beta-thalassemia trait. A statistically significant association was found between the C3F gene and homozygous beta-thalassemia. It can be suggested that this association may be related with the high incidence of infections encountered in these patients.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000235:genetics*; D004198:Disease Susceptibility; D005787:Gene Frequency; D006580:Genetic Carrier Screening; D006801:Humans; D010641:Phenotype; D011110:Polymorphism, Genetic; D013789:Thalassemia / Q000097:blood / Q000235:genetics* / Q000503:physiopathology
D003176:Complement C3