Disodium cromoglycate inhibits bronchoconstriction by kerosine aerosol in rabbits.
To determine whether or not disodium cromoglycate (DSCG) inhibits the bronchoconstriction induced by inhalation of kerosene aerosol in rabbits, we carried out a study in 31 normal rabbits which were divided into four groups. DSCG was administered through the tracheal cannula twenty minutes before exposure to kerosene aerosol. Twenty and forty milligrams of DSCG as total doses inhibited kerosene induced bronchoconstriction in large airways (RL), but 5 mg of drug did not have any effect. DSCG at any tested dose did not inhibit the decreased dynamic lung compliance (CL) which was observed after kerosene aerosol. Our findings suggest that DSCG at high dose inhibit the bronchoconstrictor effect of kerosene in large airways of rabbits.
D000336:Aerosols; D000818:Animals; D001980:Bronchi / Q000187:drug effects*; D004205:Cromolyn Sodium / Q000494:pharmacology*; D005260:Female; D007648:Kerosene / Q000009:adverse effects*; D008297:Male; D010578:Petroleum / Q000009:adverse effects*; D011817:Rabbits
D000336:Aerosols; D007648:Kerosene; D010578:Petroleum; D004205:Cromolyn Sodium