Strain variation in interferon gamma production of BCG-sensitized mice challenged with PPD. I. CBA/Ca mice are low producers in vivo, but high producers in vitro.
Three different mouse strains--BALB/c, C57BL/6J, and CBA/Ca--were compared for their production of viral interferon upon Newcastle disease virus (NDV) inoculation and of interferon gamma upon antigenic stimulation with PPD following BCG sensitization. BALB/c mice were found to be low producers for NDV-induced IFN-alpha, beta as well as for in vivo (serum) and in vitro (spleen cell culture) induced IFN-gamma. C57BL/6 mice were high producers under the three conditions tested and CBA/Ca mice, finally, were high IFN-alpha, beta and in vitro IFN-gamma producers, but low in vivo IFN-gamma producers. Development of splenomegaly following BCG inoculation was not directly related to IFN-gamma responsiveness.
D000818:Animals; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000235:genetics*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008810:Mice, Inbred C57BL / Q000276:immunology; D008808:Mice, Inbred CBA / Q000276:immunology; D008815:Mice, Inbred Strains / Q000276:immunology*; D009163:Mycobacterium bovis / Q000276:immunology*; D009522:Newcastle disease virus / Q000276:immunology; D009929:Organ Size; D013045:Species Specificity; D013154:Spleen / Q000276:immunology; D013163:Splenomegaly / Q000276:immunology; D014373:Tuberculin / Q000276:immunology*
D014373:Tuberculin; D007371:Interferon-gamma