Behavioral toxicity of trialkyltin compounds: a review.
Triethyltin (TET) and trimethyltin (TMT) are neurotoxic organotin compounds which produce different patterns of toxicity in adult animals. Exposure to TET produces behavioral toxicity (decreased motor activity, grip strength, operant response rate and startle response amplitude) which reflects impaired neuromotor function. These deficits are consistent with the reported myelin vacuolation and cerebral edema produced by TET, and with its direct effects on muscle. Exposure to TMT produces both hyperactivity and impaired learning and performance. These impairments are consistent with reported neuronal cell death produced by TMT, particularly in limbic system structures. While the behavioral deficits produced by repeated exposure to TET are reversible when dosing is terminated, the behavioral impairments produced by a single exposure to TMT appears to be irreversible.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001929:Brain Edema / Q000139:chemically induced; D003216:Conditioning, Operant / Q000187:drug effects; D006801:Humans; D007859:Learning Disabilities / Q000139:chemically induced; D008569:Memory Disorders / Q000139:chemically induced; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009422:Nervous System Diseases / Q000139:chemically induced*; D051381:Rats; D013216:Reflex, Startle / Q000187:drug effects; D012055:Reinforcement Schedule; D014220:Trialkyltin Compounds / Q000506:poisoning / Q000633:toxicity*; D014267:Triethyltin Compounds / Q000494:pharmacology; D014298:Trimethyltin Compounds / Q000494:pharmacology
D014220:Trialkyltin Compounds; D014267:Triethyltin Compounds; D014298:Trimethyltin Compounds