Effects of long-term treatment with LH on induction of cyclic ovarian activity in seasonally anoestrous ewes.
The aim of the present study was to establish whether cyclic ovarian activity could be induced and then maintained in anoestrous Romney ewes by the long-term administration of regular intravenous pulses of LH (10 micrograms ovine LH i.v. once every 1 or 2 h for 29-91 days). The LH pulse regimen was designed to generate plasma profiles of LH that were comparable to those experienced during the luteal and follicular phases of the oestrous cycle. The results showed that the LH treatments were capable of inducing cyclic ovarian activity, as assessed from the concentrations of progesterone in plasma, but that the treatments were inadequate for sustaining cyclic activity beyond two consecutive progestational phases. After 35-56 days of treatment, the plasma concentrations of FSH declined significantly (P less than 0.05) relative to those in the untreated animals. These data suggest that FSH supplementation as well as LH might be required for the long-term maintenance of cyclic ovarian activity in seasonally anoestrous ewes.
D000818:Animals; D004971:Estrus / Q000187:drug effects*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood / Q000494:pharmacology*; D010053:Ovary / Q000187:drug effects; D011247:Pregnancy; D011359:Proestrus / Q000187:drug effects; D011374:Progesterone / Q000097:blood; D012621:Seasons; D012756:Sheep; D013997:Time Factors
D011374:Progesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone