Pyrimidine biosynthesis in Neisseria meningitidis. 2. Regulation of enzyme synthesis.
In Neisseria meningitidis aspartate carbamoyltransferase (ACTase), ornithine carbamoyltransferase (OCTase), and carbamoylphosphate synthetase (CPSase) showed incomplete repression by uracil and arginine. De-repression studies with pyrimidine and arginine mutants showed no de-repressed levels of these enzymes.
D001120:Arginine / Q000494:pharmacology; D001221:Aspartate Carbamoyltransferase / Q000096:biosynthesis; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing) / Q000096:biosynthesis; D009345:Neisseria meningitidis / Q000201:enzymology*; D009954:Ornithine Carbamoyltransferase / Q000096:biosynthesis; D011743:Pyrimidines / Q000096:biosynthesis*; D014498:Uracil / Q000494:pharmacology
D011743:Pyrimidines; D014498:Uracil; D001120:Arginine; D001221:Aspartate Carbamoyltransferase; D009954:Ornithine Carbamoyltransferase; D002223:Carbamoyl-Phosphate Synthase (Glutamine-Hydrolyzing)