A new immunoglobulin marker.
In an examination of 16 human immunoglobulin lambda-light chains, one was found to have amino acid substitutions which have not previously been reported for the constant region of the lambda-chains. It involved in two positions: an arginine instead of lysine at position 130, and a leucine for glutamine at position 195 (Sh numbering (1) ). The structural variation is tentatively designated as "Is" marker.
D000595:Amino Acid Sequence; D001536:Bence Jones Protein / Q000032:analysis; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007146:Immunoglobulin lambda-Chains / Q000032:analysis*
D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains; D001536:Bence Jones Protein