Disorders of granulopoiesis in patients with untreated Graves' disease.
Total and differential leucocyte countings, mobilization of the marrow granulocyte reserve with hydrocortisone and growth of blood colony-forming cells (CFU-C) in agar culture have been evaluated in 17 patients with Graves' disease before therapy. Moreover, the myeloid differentiation of blood CFU-C in liquid culture has been studied in 4 patients. Neutropenia was found in only 1 patient (5.9%), while the marrow granulocyte reserve was reduced in 7 out of 15 patients (46.7%). Blood concentration of CFU-C and myeloid differentiation in liquid culture were normal in all patients studied. These data show an abnormal granulopoiesis in a high percentage of patients with untreated Graves' disease. The mechanisms accounting for the reduction of the marrow granulocyte reserve in patients with Graves' disease are discussed.
D000293:Adolescent; D000328:Adult; D001854:Bone Marrow Cells; D003114:Colony-Forming Units Assay; D005260:Female; D006098:Granulocytes / Q000166:cytology*; D006111:Graves Disease / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D006410:Hematopoiesis; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology