The protective effects of EDTA against copper poisoning in rats with special reference to the kidney.
This study reports on the protective effects of EDTA against copper poisoning with special reference to the kidney of the rat, Rattus rattus (albino), observed by means of various parameters. The data obtained on the improvement in body weight and skeletal growth, and the reduction in the numbers of lesions and the amount of lipids, are evidence of the necrotropic and lipotropic behaviour of EDTA. The reversal of key enzymes reflects a repair in membranes. Other pharmacotoxicological aspects of EDTA are also discussed.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003300:Copper / Q000506:poisoning*; D004492:Edetic Acid / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008297:Male; D051381:Rats
D003300:Copper; D004492:Edetic Acid