Plasmapheresis in Rh hemolytic disease: the danger of amniocentesis.
We have treated 25 women with poor obstetric histories and high levels of anti-Rh antibodies by plasmapheresis during pregnancy. One baby was Rs negative, but 13 of the remaining 24 babies survived. Most of the foetal deaths were associated with a rapid rise in antibody level uncontrollable by plasmapheresis and which followed either amniocentesis or intra-uterine transfusion. Plasmapheresis throughout pregnancy with early delivery and avoidance of amniocentesis is recommended.
D000649:Amniocentesis / Q000009:adverse effects*; D000906:Antibodies / Q000032:analysis; D004899:Erythroblastosis, Fetal / Q000628:therapy*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010956:Plasmapheresis; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System
D000906:Antibodies; D012204:Rh-Hr Blood-Group System