Coincident secretion of follicle-stimulating hormone and luteinizing hormone in early postpartum beef cows: effects of suckling and low-level increases of systemic progesterone.
The current experiment was conducted with beef cows during the first 2 weeks postpartum (PP) to determine the effects of suckling and low-level increases of systemic progesterone on secretory characteristics of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) in peripheral plasma. Variables measured included mean gonadotropin concentrations, FSH/LH pulse frequencies, pulse amplitudes and synchrony of coincident release. Suckled (S) cows had lower (P less than 0.01-P less than 0.05) mean concentrations of FSH and LH in plasma, lower (P less than .05) FSH and LH pulse frequencies and a lower (P less than 0.05) pulse synchrony (21.6 vs 72.3% coincident pulses) than nonsuckled (NS) cows on Day 7 PP. Neither FSH nor LH pulse amplitude was affected by suckling. Similar differences existed for mean gonadotropin concentrations, pulse frequencies and pulse synchrony on Day 14 PP between S and NS cows. Implanting cows with progesterone implants on Day 7 PP, which chronically increased plasma progesterone to 0.5-0.6 ng/ml, increased (P less than 0.05) mean plasma FSH and LH concentrations, FSH and LH pulse frequencies and pulse synchrony (87.5 vs. 66.3%) in NS-implanted (NSI) versus NS-nonimplanted (NSNI) cows. Progesterone implants had no beneficial effect in S cows. Thus, three major findings seem pertinent: 1) associated with the suckling-induced depression of episodic gonadotropin release was a marked decline in FSH/LH pulse synchrony; 2) a high degree of FSH/LH pulse synchrony (72-88%) was restored in the absence of suckling when gonadotropin pulse frequency increased to 4-5/6 h; 3) the absence of suckling, followed by the provision of low-level progesterone stimulation for 7 days, appeared to have additive effects on FSH and LH secretion. These results provide evidence that the neuroendocrine block associated with suckling in early PP beef cows is, in addition to being associated with depressed LH release, comprised of characteristic anomalies in FSH secretion, FSH/LH pulse synchrony and failure to respond to a putative hypothalamo-hypophyseal potentiator, progesterone.
D000818:Animals; D002417:Cattle; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D007774:Lactation; D007986:Luteinizing Hormone / Q000378:metabolism*; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D013997:Time Factors
D007987:Gonadotropin-Releasing Hormone; D011374:Progesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone