Emergence of a hybrid surface phenotype in mixed blast crisis of chronic granulocytic leukaemia.
A 40-year-old man with Philadelphia chromosome-positive chronic granulocytic leukaemia developed blast crisis with a mixture of lymphoid and myeloid blasts. A bone marrow relapse with predominantly myeloid features was followed by meningeal leukaemia of purely lymphoid differentiation. The terminal crisis showed a homogenous population of large unclassifiable blasts with simultaneous expression of lymphoid and myelomonocytic surface antigens. The repeated phenotypic conversions were documented by morphological studies and by cell marker analysis with monoclonal antibodies.
D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000032:analysis / Q000276:immunology; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D002904:Chromosomes, Human, 21-22 and Y; D006801:Humans; D007951:Leukemia, Myeloid / Q000134:cerebrospinal fluid / Q000235:genetics* / Q000473:pathology; D008297:Male; D008577:Meningeal Neoplasms / Q000134:cerebrospinal fluid / Q000235:genetics / Q000473:pathology; D010641:Phenotype
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface