Experience with highly purified porcine factor VIII in a patient with haemophilia A and a factor VIII inhibitor.
Highly purified porcine factor VIII has been advocated for the treatment of bleeding episodes in patients with haemophilia who have inhibitors to factor VIII. This approach has been successful in a patient with an intermediate potency inhibitor showing little cross-reactivity to porcine material. As in some other reported cases, a severe allergic reaction occurred on one occasion but did not preclude the subsequent use of the porcine concentrate in carefully controlled conditions.
D000328:Adult; D000818:Animals; D003429:Cross Reactions; D005169:Factor VIII / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D006467:Hemophilia A / Q000188:drug therapy*; D006801:Humans; D008297:Male; D013552:Swine
D005169:Factor VIII