Reacquisition of specific proteins confers virulence in Mycoplasma pneumoniae.
Hemadsorbing revertants were isolated from spontaneous hemadsorption-negative, avirulent mutants of Mycoplasma pneumoniae. The revertants simultaneously reacquired specific proteins absent in their homologous mutants, along with neuraminidase-sensitive adherence to the respiratory epithelium and virulence. Peptide mapping and immunological analysis indicated no precursor-product relationships among certain of these proteins.
D000268:Adhesiveness; D000818:Animals; D001426:Bacterial Proteins / Q000502:physiology*; D006224:Cricetinae; D006382:Hemadsorption; D008168:Lung / Q000382:microbiology; D008647:Mesocricetus; D009154:Mutation; D009177:Mycoplasma pneumoniae / Q000032:analysis / Q000235:genetics / Q000472:pathogenicity*; D010455:Peptides / Q000032:analysis
D001426:Bacterial Proteins; D010455:Peptides