The chemistry of bupropion.
The chemical structure and synthesis of bupropion are described and compared with typical polycyclic antidepressants to point up the novelty and simplicity of this drug. The features of bupropion's substructure are discussed to help in understanding the observed pharmacological differences among bupropion, tricyclic antidepressants, and psychostimulants.
D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis / Q000494:pharmacology; D016642:Bupropion; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice; D011427:Propiophenones / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000928:Antidepressive Agents; D011427:Propiophenones; D016642:Bupropion