Defective platelet aggregation to the calcium ionophore A23187 in a patient with a lifelong bleeding disorder.
A patient with a lifelong bleeding disorder is presented with a prolonged bleeding time and abnormal aggregation and secretion responses to arachidonic acid, thromboxane A2, PAF-acether and the divalent calcium ionophore A23187. Platelet alpha and dense granule contents and morphology appear normal. The proposed defect is due to an abnormality of a platelet intracellular calcium dependent process.
D001095:Arachidonic Acids / Q000378:metabolism / Q000494:pharmacology; D001760:Bleeding Time; D001791:Blood Platelet Disorders / Q000097:blood*; D000001:Calcimycin / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D009711:Nucleotides / Q000097:blood; D010972:Platelet Activating Factor / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D013928:Thromboxane A2 / Q000494:pharmacology
D001095:Arachidonic Acids; D009711:Nucleotides; D010972:Platelet Activating Factor; D000001:Calcimycin; D013928:Thromboxane A2; D002118:Calcium