Tixocortol pivalate, a corticosteroid with no systemic glucocorticoid effect after oral, intrarectal, and intranasal application.
Tixocortol pivalate is a corticosteroid with topical anti-inflammatory activity equal to that of hydrocortisone. It was evaluated in a group of 18 normal subjects to determine whether it exerted any systemic glucocorticoid activity after single oral or intrarectal doses and after short-term dosing by the intranasal route. Effects of tixocortol pivalate were compared to those of oral dexamethasone and intrarectal betamethasone 21-phosphate. By the three routes, tixocortol pivalate does not induce any changes in plasma cortisol, leukocyte counts (neutrophils, lymphocytes, monocytes, eosinophils), blood glucose, or 24-hr urinary excretion of sodium and potassium, whereas there were changes after dexamethasone and betamethasone. Tixocortol pivalate, however, increased urinary free cortisol-like substances. It is concluded that tixocortol pivalate given for short periods by nonparenteral routes does not induce a measurable systemic glucocorticoid effect.
D000281:Administration, Intranasal; D000284:Administration, Oral; D000328:Adult; D000523:Algestone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D000463:Algestone Acetophenide / Q000031:analogs & derivatives*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001623:Betamethasone / Q000031:analogs & derivatives / Q000494:pharmacology; D001786:Blood Glucose / Q000032:analysis; D003907:Dexamethasone / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism / Q000031:analogs & derivatives; D007958:Leukocyte Count; D008297:Male; D012007:Rectum
D000893:Anti-Inflammatory Agents; D001786:Blood Glucose; D000523:Algestone; C019112:tixocortol pivalate; C028994:betamethasone sodium phosphate; D003907:Dexamethasone; D001623:Betamethasone; D000463:Algestone Acetophenide; D006854:Hydrocortisone