[Induction by mycotoxins of somatic mosaicism in Drosophila and DNA repair in mammalian liver cell cultures].
The genotoxic activity of four mycotoxins has been studied. High level of somatic mutagenesis in imaginal discs of Drosophila melanogaster larvae and DNA repair synthesis in human embryo and adult rat liver cell cultures were inducible only by highly carcinogenic aflatoxin B1. Patulin, a weak direct-action carcinogenic substance, slightly elevated the mutagenesis in somatic cells of Drosophila but did not induce DNA repair synthesis in liver cell cultures. Citrinin that did not exhibit any carcinogenic properties when used alone and stachybotrotoxin with non-reported carcinogenic activity appeared inactive in the test-systems applied. The possibilities of rapid recognition of carcinogenic mycotoxins by detecting their genotoxic properties are discussed.
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000235:genetics; D000818:Animals; D002273:Carcinogens; D002953:Citrinin / Q000494:pharmacology; D004260:DNA Repair / Q000187:drug effects*; D004331:Drosophila melanogaster / Q000235:genetics; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D009030:Mosaicism / Q000187:drug effects*; D009183:Mycotoxins / Q000494:pharmacology*; D010365:Patulin / Q000235:genetics; D051381:Rats; D011919:Rats, Inbred Strains
D000348:Aflatoxins; D002273:Carcinogens; D009183:Mycotoxins; C038398:stachybotrotoxin; D002953:Citrinin; D010365:Patulin; D016604:Aflatoxin B1
Induktsiia mikotoksinami somaticheskogo mozaitsizma u drozofily i reparatsii DNK v kul'turakh kletok pecheni mlekopitaiushchikh.