Relationship between plasma levels of factor VIII related antigen and reticulo-endothelial function in chronic uremia.
The plasma levels of factor VIII related antigen (F VIIIR:Ag; determined by rocket electrophoresis) and reticulo-endothelial function (measured by means of the removal kinetics of human albumin millimicrospheres) were studied in a group of patients with chronic renal failure. F VIIIR:Ag plasma levels were increased, median 304% (interquartile ranges 211-443%) compared to the controls, median 112% (interquartile ranges 100-144%); P less than 0.01. Reticulo-endothelial function was decreased, median 8.3 micrograms/min/kg body wt (interquartile ranges 6.2-10.1 micrograms/min/kg body wt) compared to the controls, median 15.0 micrograms/min/kg body wt (interquartile ranges 11.9-19.0 micrograms/min/kg body wt); P less than 0.02. A significant inverse relationship was found between plasma levels of F VIIIR:Ag and the reticulo-endothelial function rs = 0.075; P less than 0.01). As the main site of catabolism of F VIIIR:Ag is the reticulo-endothelial system, the impairment of its function appears to be a possible explanation for the elevated plasma levels of the F VIIIR:Ag found in patients with end stage renal disease.
D000328:Adult; D000368:Aged; D000941:Antigens / Q000032:analysis*; D002908:Chronic Disease; D005169:Factor VIII / Q000032:analysis / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D012157:Mononuclear Phagocyte System / Q000378:metabolism / Q000503:physiopathology*; D012016:Reference Values; D014511:Uremia / Q000097:blood* / Q000503:physiopathology; D014841:von Willebrand Factor
D000941:Antigens; D014841:von Willebrand Factor; D005169:Factor VIII