Successful intracerebral allotransplantation of purified pancreatic endocrine cells in diabetic rat.
Single pancreatic endocrine cells (PEC) have been demonstrated to restore normoglycemia when transplanted intracerebrally in diabetic rat recipients across a major histocompatibility barrier without immunosuppression. Twelve out of twelve transplants of purified PEC have achieved long-term survival of over 176 days. This approach would provide a model to identify the specific cell(s) as inducer of graft rejection and an opportunity for transplantation study in spontaneous diabetic BB rats and larger diabetic animal models.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000628:therapy*; D006085:Graft Survival; D016381:Islets of Langerhans Transplantation; D008297:Male; D051381:Rats; D011912:Rats, Inbred ACI; D011917:Rats, Inbred Lew
D001786:Blood Glucose