Stimulation of lymphokine production by teleocidin, aplysiatoxin, and debromoaplysiatoxin.
Previous studies showed that the tumor-promoting phorbol ester 12-O-tetradecanoylphorbol 13-acetate (TPA) and several structurally related tumor-promoting compounds stimulate lymphocytes to produce immune interferon (IFN-gamma) and interleukin 2 (IL-2). This study shows that three compounds structurally unrelated to TPA, previously shown to mimic TPA in some other biological activities, are similar to TPA in stimulating IFN-gamma and Il-2 production in cultures of human peripheral blood lymphocytes. The production of another lymphokine, termed lymphotoxin (LT), was also enhanced by TPA and the other three compounds examined. Maximal enhancement of lymphokine production was observed in cultures costimulated with TPA or one of the other tested compounds and phytohemagglutinin (PHA). TPA was separated from IFN-gamma during a multistep purification procedure.
D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology*; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D007783:Lactones / Q000494:pharmacology; D008213:Lymphocyte Activation; D008233:Lymphotoxin-alpha / Q000096:biosynthesis*; D008235:Lyngbya Toxins; D008387:Marine Toxins / Q000494:pharmacology*; D051379:Mice; D010835:Phytohemagglutinins / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D000470:Alkaloids; D007369:Interferon Inducers; D007376:Interleukin-2; D007783:Lactones; D008233:Lymphotoxin-alpha; D008235:Lyngbya Toxins; D008387:Marine Toxins; D010835:Phytohemagglutinins; C022176:teleocidins; C017179:debromoaplysiatoxin; C006610:aplysiatoxin; D007371:Interferon-gamma; D013755:Tetradecanoylphorbol Acetate