"Drug-resistant proportion test" for M. leprae to quantify the proportion of drug-resistant M. leprae in a sample using the mouse foot pad.
The mouse foot pad test has not previously been used quantitatively to discriminate between samples of Mycobacterium leprae with differing proportions of drug-resistant M. leprae. The "drug-resistant proportion test" is a simple modification of the routine mouse foot pad test. It is demonstrated to distinguish between samples of M. leprae with a tenfold difference in the proportion of dapsone-resistant M. leprae.
D000818:Animals; D003622:Dapsone; D004352:Drug Resistance, Microbial; D009115:Muridae; D009166:Mycobacterium leprae / Q000187:drug effects / Q000302:isolation & purification*
D003622:Dapsone