In vitro activity of pristinamycin against methicillin-resistant Staphylococcus aureus.
An agar dilution technique was used to determine the MIC of pristinamycin for 124 clinical isolates of methicillin-resistant Staphylococcus aureus. All were inhibited by less than or equal to 0.5 mg/1, quite similar to the sensitivity of a number of methicillin-sensitive strains. MICs obtained using a microdilution method were also comparable. Antagonism was seen with the combination of pristinamycin and erythromycin.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003470:Culture Media; D004347:Drug Interactions; D008712:Methicillin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D010455:Peptides / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*; D014769:Virginiamycin
D000900:Anti-Bacterial Agents; D003470:Culture Media; D010455:Peptides; D014769:Virginiamycin; D008712:Methicillin