Selected opioids, ethanol and intake of ethanol.
Rats were given an opportunity to drink tap water or a sweetened ethanol solution once a day. Across initial days of opportunity, rats increased their intake of the ethanol solution. Prior to some days' sessions with presented fluids, rats received either an injection of placebo (the carrier of drugs) or doses of ethylketocyclozocine, diprenorphine, or ethanol. Diprenorphine increased rats' intake of the ethanol solution compared to placebo. The other agents did not reliably modify intakes. These findings support a conclusion that selected activity in opioid systems of brain increase the propensity to drink alcoholic beverages.
D000428:Alcohol Drinking; D000437:Alcoholism / Q000209:etiology; D000818:Animals; D003496:Cyclazocine / Q000031:analogs & derivatives / Q000494:pharmacology; D004174:Diprenorphine / Q000494:pharmacology; D004723:Endorphins / Q000502:physiology*; D000431:Ethanol / Q000494:pharmacology*; D016314:Ethylketocyclazocine; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004723:Endorphins; D004174:Diprenorphine; D000431:Ethanol; D016314:Ethylketocyclazocine; D003496:Cyclazocine