Effect of dexamethasone on testicular enzymes of the Embden-Meyerhof and pentose-phosphate pathways.
The influence of dexamethasone on the specific activities of testicular enzymes involved in the Embden-Meyerhof and pentose-phosphate pathways was studied in pre-pubertal, pubertal and adult rats. All of the enzymes showed a decrease in specific activity after dexamethasone treatment, an effect which was most drastic in pre-pubertal animals. After cessation of treatment, the specific activity of all the enzymes reverted to normal levels, except for glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in the pre-pubertal group.
D000375:Aging; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D005640:Follicle Stimulating Hormone / Q000097:blood; D005947:Glucose / Q000378:metabolism*; D006728:Hormones / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010428:Pentosephosphates / Q000378:metabolism*; D011388:Prolactin / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000187:drug effects / Q000201:enzymology*; D013739:Testosterone / Q000097:blood
D006728:Hormones; D010428:Pentosephosphates; D013739:Testosterone; D003907:Dexamethasone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D005947:Glucose