Variations of fatty acid composition of erythrocyte and plasma lipids in the rat during the first period of life.
The changes occurring in the fatty acid composition of the erythrocyte lipids during the first weeks of life were studied in the rat. The major changes consisted of a progressive decrease in oleic acid and a progressive increase in linoleic acid. A lower but significant increase in arachidonic acid was also observed. These changes are not related to variations in erythrocyte age; rather, they appear to be related to the age of the animal. Since somewhat similar changes were observed in the fatty acid composition of the major lipid classes of plasma during the first weeks of life, the possibility that these variations could account for the changes in the fatty acid composition of erythrocyte lipids was considered. Some support to this possibility was found in the results of experiments in which erythrocytes taken from 15-day-old rats were incubated with plasma taken from newborn rats. The changes in the fatty acid composition of erythrocytes and plasma lipids do not appear to be dependent on dietary lipids, since they occur during the suckling period, i.e., before the rats begin to ingest the pelleted diet which presents a fatty acid pattern completely different to that of the dams' milk.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000097:blood; D004912:Erythrocytes / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000097:blood; D008055:Lipids / Q000097:blood*; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains
D001095:Arachidonic Acids; D005227:Fatty Acids; D008041:Linoleic Acids; D008055:Lipids; D009829:Oleic Acids; D016718:Arachidonic Acid; D019301:Oleic Acid; D019787:Linoleic Acid