Inhibition by AA861 of prostaglandin E2 production by activated peritoneal macrophages of rat.
Prostaglandin E2 production by rat peritoneal activated macrophages was inhibited by AA861 which had been reported as a selective inhibitor of 5-lipoxygenase from guinea pig peritoneal leukocytes. At a dose of 3.06 microM, prostaglandin E2 production was decreased to 27% of control. No inhibition of the release of (3H)arachidonic acid from the prelabeled macrophages was observed at the dose.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D016227:Benzoquinones; D015232:Dinoprostone; D007700:Kinetics; D008262:Macrophage Activation; D008264:Macrophages / Q000378:metabolism*; D011458:Prostaglandins E / Q000096:biosynthesis*; D011809:Quinones / Q000494:pharmacology*; D051381:Rats; D014316:Tritium
D001095:Arachidonic Acids; D016227:Benzoquinones; D011458:Prostaglandins E; D011809:Quinones; D014316:Tritium; D016718:Arachidonic Acid; C036837:2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone; D015232:Dinoprostone