Evaluation of mutagenic effect of the fungicide fenaminosulf in Drosophila melanogaster.
Fenaminosulf (p-dimethylaminobenzenediazo sodium sulfonate, CAS registry No. 140-56-7) which is an active ingredient in several commercial fungicides was reported to be mutagenic in Salmonella typhimurium (McCann et al., 1975), Bacillus subtilis (Kada et al., 1974) and shown to cause chromosome aberrations in plants (Zutshi and Kaul, 1975). Since fenaminosulf has structural similarity to the potent carcinogen, butter yellow (p-dimethylaminoazobenzene, CAS registry No. 60-11-7), the present studies were undertaken to evaluate the mutagenic potential of this fungicide in Drosophila melanogaster. Fenaminosulf administered at 10 mg/100 ml food medium failed to induce sex-linked recessive mutations in Drosophila. Since Drosophila has drug-metabolizing enzymes similar to those of mammals (Vogel, 1975), it is suggested that the lack of mutagenic activity of fenaminosulf could be due to the conversion of fenaminosulf to non-mutagenic derivatives in Drosophila.
D000818:Animals; D001557:Benzenesulfonates / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000187:drug effects*; D005659:Fungicides, Industrial / Q000494:pharmacology*; D005808:Genes, Recessive / Q000187:drug effects; D008040:Genetic Linkage; D009153:Mutagens; D012730:Sex Chromosomes
D001557:Benzenesulfonates; D005659:Fungicides, Industrial; D009153:Mutagens; C007287:dexon (fungicide), sodium salt