In vitro study of in line filtration of medications commonly administered to pediatric cancer patients.
Intravenous administration of drugs commonly used in patients with acute nonlymphocytic leukemia was simulated using a .22 micrometers air-eliminating filter. Drug concentrations were measured pre- and postfiltration using standard pediatric drug doses and concentrations. The percentage of administered dose recovered in the postfilter sample for chemotherapy drugs was adriamycin, 92%; dactinomycin, 87%; cytarabine, 96%; and vincristine, 90%. For antibiotics, the per cent recovery was carbenicillin, 90%; cephalothin, 96%; and gentamicin, 38%. Gentamicin, and perhaps other drugs evaluated, should not be administered through a filter of the type used in this study.
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002648:Child; D005374:Filtration; D006801:Humans; D007263:Infusions, Parenteral / Q000379:methods; D009369:Neoplasms / Q000188:drug therapy; D010289:Parenteral Nutrition, Total
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents