Red cell sensitization due to anti-D in anti-lymphocyte globulin.
Four Rh-positive patients with severe aplastic anemia received equine anti-lymphocyte globulin. Each developed a positive direct antiglobulin test. Anti-D was identified in eluates prepared from the patients' sensitized red cells. The administered lot of anti-lymphocyte globulin was found to contain anti-D. Red cell sensitization due to passively acquired Rh antibodies can result from the administration of anti-lymphocyte globulin.
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy; D000818:Animals; D000961:Antilymphocyte Serum / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D004340:Drug Contamination; D006736:Horses; D006801:Humans; D007116:Immunization, Passive; D007518:Isoantibodies / Q000032:analysis*; D008875:Middle Aged; D012204:Rh-Hr Blood-Group System / Q000276:immunology*
D000961:Antilymphocyte Serum; D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System