Abnormally elevated pregnancy specific beta 1 glycoprotein (SP1 beta) with very low placental lactogen (hPL) concentrations in a pregnancy with satisfactory outcome.
Pregnancies with very low maternal serum concentrations of placental function monitors, yet resulting in a normal outcome, have been reported occasionally before (4, 6). We report here a case in which maternal serum placental lactogen (hPL) concentrations were very low, urinary estrogen output assessed by estrogen/creatinine ratio was satisfactory, but maternal serum pregnancy specific beta 1 glycoprotein (SP1 beta) concentrations were grossly elevated. Ultrasound findings suggested impairment of growth. The outcome of the pregnancy was satisfactory, although the baby, apparently of 38-40 weeks' gestation, developed mild respiratory distress.
D000328:Adult; D003404:Creatinine / Q000652:urine; D004967:Estrogens / Q000652:urine; D005260:Female; D005317:Fetal Growth Retardation / Q000175:diagnosis; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010928:Placental Lactogen / Q000097:blood*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000032:analysis*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000032:analysis*; D012127:Respiratory Distress Syndrome, Newborn / Q000209:etiology; D014463:Ultrasonography
D004967:Estrogens; D011257:Pregnancy Proteins; D011268:Pregnancy-Specific beta 1-Glycoproteins; D010928:Placental Lactogen; D003404:Creatinine