[Serum potentiation of hemolysis induced in vitro by adriamycin in man].
Human red cells lysis produced by adriamycin in vitro was investigated both in phosphate medium pH7 and in human serum. Drug induced hemolysis, that appeared with concentrations markedly above plasmatic levels seen in therapeutic, was stongly enhanced by serum. It is the first relations of modulation through a human serum factor of a biological action of adriamycin.
D001790:Blood Physiological Phenomena; D004317:Doxorubicin / Q000494:pharmacology*; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques
D004317:Doxorubicin
Potentialisation par le sérum de l'hémolyse induite in vitro par l'adriamycine, chez l'homme.