m- And p-halobenzoyl derivatives of p-halo-DL-phenylalanine as inhibitors in a microbial antitumor prescreen.
Meta- and p-halobenzoyl-p-halo-phenylalanine compounds were prepared and tested for growth-inhibitory activity in a Lactobacillus casei system. The activity of 13 of the most active of these compounds, reported here, was greater than that of any other acyl derivatives of amino acid analogs previously studied in this system and was from 2 to 8 times greater than that of 6-mercaptopurine, a known antitumor agent.
D000970:Antineoplastic Agents; D055598:Chemical Phenomena; D002621:Chemistry; D007780:Lacticaseibacillus casei / Q000187:drug effects*; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology
D000970:Antineoplastic Agents; D010649:Phenylalanine