2-Aminodipyrido[1,2-a:3',2'-d]imidazole-porphyrin(Fe) derivatives as sequence specific DNA cleaving reagents.
Some porphyrin (Fe)-intercalators were synthesized. We chose 2-aminodipyrido[1, 2-a:3',2'-d]imidazoles (Glu-P's), which were muta-carcinogens isolated from a pyrolysate of L-glutamic acid, as intercalator moieties. These synthetic porphyrin (Fe)-intercalators cleave DNA at G-C and G-T sequences. The specificity for cleavage of base sequences of DNA is quite similar to that of bleomycin.
D000631:Aminopyridines / Q000138:chemical synthesis; D001483:Base Sequence; D004247:DNA; D004926:Escherichia coli / Q000235:genetics; D007093:Imidazoles / Q000138:chemical synthesis; D007364:Intercalating Agents / Q000138:chemical synthesis*; D010957:Plasmids; D011166:Porphyrins / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
D000631:Aminopyridines; D007093:Imidazoles; D007364:Intercalating Agents; D011166:Porphyrins; D004247:DNA