Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin.
Human tumour necrosis factor has about 30% homology in its amino acid sequence with lymphotoxin, a lymphokine that has similar biological properties. Recombinant tumour necrosis factor can be obtained by expression of its complementary DNA in Escherichia coli and induces the haemorrhagic necrosis of transplanted methylcholanthrene-induced sarcomas in syngeneic mice.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics; D005786:Gene Expression Regulation; D006023:Glycoproteins / Q000235:genetics* / Q000627:therapeutic use; D006801:Humans; D008222:Lymphokines / Q000235:genetics; D008233:Lymphotoxin-alpha / Q000235:genetics; D051379:Mice; D011498:Protein Precursors / Q000235:genetics; D012513:Sarcoma, Experimental / Q000628:therapy; D014409:Tumor Necrosis Factor-alpha
D006023:Glycoproteins; D008222:Lymphokines; D008233:Lymphotoxin-alpha; D011498:Protein Precursors; D014409:Tumor Necrosis Factor-alpha; D004247:DNA