Benzodiazepine-induced thrombocytopenia. Demonstration of drug-dependent platelet antibodies in two cases.
Two cases of benzodiazepine-induced thrombocytopenia are described. Drug-dependent antibodies with antiplatelet activity of the IgG class were detected by inhibition of complement-dependent hemolysis. This technique permitted also the demonstration of cross-reactivity of these antibodies with different benzodiazepines.
D000328:Adult; D000906:Antibodies / Q000276:immunology; D001569:Benzodiazepines / Q000009:adverse effects*; D001792:Blood Platelets / Q000276:immunology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008875:Middle Aged; D013921:Thrombocytopenia / Q000139:chemically induced*
D000906:Antibodies; D007136:Immunoglobulins; D001569:Benzodiazepines