Glucocorticoid receptors in leukemia cells: an appraisal.
There is growing interest in the molecular events which govern response to therapy in the leukemias. Glucocorticoid therapy would appear to be a fertile area for study as much is known about mechanism of steroid hormone action. In this paper we review current knowledge of glucocorticoid receptor numbers and function in leukemic blast cells and their relationship to steroid treatment and outcome.
D000818:Animals; D002478:Cells, Cultured; D002848:Chromatography, DEAE-Cellulose; D004351:Drug Resistance; D005938:Glucocorticoids / Q000494:pharmacology; D006801:Humans; D007938:Leukemia / Q000188:drug therapy / Q000378:metabolism*; D011965:Receptors, Glucocorticoid / Q000032:analysis*; D011987:Receptors, Steroid / Q000032:analysis*; D014222:Triamcinolone Acetonide / Q000378:metabolism
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D014222:Triamcinolone Acetonide