Purified human granulocyte-macrophage colony-stimulating factor: direct action on neutrophils.
Neutrophil migration inhibition factor from T lymphocytes (NIF-T) is a lymphokine that acts to localize granulocytes. Medium conditioned by the Mo human T-lymphoblast cell line was used to purify NIF-T, a glycoprotein with a molecular weight of 22,000. The NIF-T was found to potently stimulate the growth of granulocyte and macrophage colonies from human bone marrow and colony formation by the KG-1 myeloid leukemia cell line. Thus a human lymphokine (NIF-T) that modulates the activities of mature neutrophilic granulocytes is also a colony-stimulating factor acting on precursors to induce growth and differentiation of new effector cells.
D001854:Bone Marrow Cells; D002455:Cell Division; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D003115:Colony-Stimulating Factors / Q000302:isolation & purification*; D004591:Electrophoresis, Polyacrylamide Gel; D006098:Granulocytes / Q000166:cytology*; D006801:Humans; D007961:Leukocyte Migration-Inhibitory Factors / Q000494:pharmacology*; D008222:Lymphokines / Q000494:pharmacology*; D008264:Macrophages / Q000166:cytology*; D008970:Molecular Weight
D003115:Colony-Stimulating Factors; D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines