Effect of Lactobacillus inoculation and antibiotic feeding of chickens on availability of dietary biotin.
Oral inoculation with Lactobacillus acidophilus and dietary supplementation with antibiotics were compared in broiler chicks fed various levels of biotin to determine their effect on the biotin status of the chicks. Lactobacillus acidophilus inoculation of broiler chickens fed a diet marginally deficient in biotin (56 micrograms/kg) caused a significant decrease (P less than .01) in their liver biotin content from 1596 to 931 ng/g. The decrease biotin status was confirmed by significant increases (P less than .01) in 16:1 and 18:1 plasma fatty acids and significant decreases (P less than .01) in 18:0 and 20:4 omega 6 plasma fatty acids. These alterations in fatty acids were only observed when the samples were taken from chickens in the fed condition. Supplementation with Lactobacillus caused an increased incidence of foot dermatitis and decreased growth of chickens, presumably by competing with the chicken for dietary biotin. No significant changes were noted with antibiotic feeding.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001682:Biological Availability; D001710:Biotin / Q000008:administration & dosage / Q000378:metabolism*; D001835:Body Weight; D002645:Chickens / Q000378:metabolism*; D004032:Diet; D005227:Fatty Acids / Q000097:blood; D007779:Lactobacillus acidophilus / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D009751:Nutritional Requirements; D009929:Organ Size
D000900:Anti-Bacterial Agents; D005227:Fatty Acids; D001710:Biotin