Comparison of ceftazidime concentrations in bile and serum.
Biliary excretion of ceftazidime, a new broad-spectrum cephalosporin, was studied in two groups of patients after administration of a 2-g dose intravenously. Group A included 10 patients in whom ceftazidime levels in bile were measured during cholecystectomy. Group B included 10 patients with indwelling biliary tubes in whom ceftazidime levels in bile and serum were simultaneously measured at 0.5, 1, 2, 4, 6, and 8 h after administration of the drug. Although ceftazidime levels were variable, they exceeded the minimal inhibitory concentrations of most biliary tract pathogens in both groups.
D000328:Adult; D000368:Aged; D001646:Bile / Q000378:metabolism*; D001662:Biliary Tract Surgical Procedures; D002442:Ceftazidime; D002511:Cephalosporins / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D002511:Cephalosporins; D002442:Ceftazidime