Failure of dorsal bundle lesions in rats to increase distractibility to a low intensity tone.
Bilateral lesions of the dorsal noradrenergic bundle in rat brains with 6-hydroxydopamine produced a depletion of cortical noradrenaline to 19% of control values. Rats so treated showed resistance to extinction of a lever press task but no increased distractability from licking behaviour by a low intensity tone. These results cast doubt on the hypothesis that dorsal noradrenergic bundle lesions cause hyperdistractibility in rats.
D000161:Acoustic Stimulation; D000818:Animals; D001288:Attention / Q000187:drug effects / Q000502:physiology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D006892:Hydroxydopamines / Q000494:pharmacology*; D008125:Locus Coeruleus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains
D006892:Hydroxydopamines; D016627:Oxidopamine; D009638:Norepinephrine