[Demonstration of an abnormal increase of anti-T hemagglutinin titers in malaria infected patients].
An increased frequency of high titers of antibodies against A, B, ORh+ trypsinized, and ORh+ neuraminidase-treated human red blood cells was observed in the sera of Africans living in a malaria endemic area, and Europeans with primary malaria attacks. In the latter group, titers of agglutinins against neuraminidase treated RBC were increased in 84% of individuals and were of the IgM class. Inhibition experiments with beta-D-galactose and lactose showed that this agglutinin was directed to the T antigen of human RBC. Its possible implication in malaria related anemia is discussed.
D000017:ABO Blood-Group System / Q000276:immunology*; D000906:Antibodies / Q000032:analysis*; D004912:Erythrocytes / Q000276:immunology; D005690:Galactose; D006386:Hemagglutination Tests; D006388:Hemagglutinins / Q000032:analysis*; D006801:Humans; D008288:Malaria / Q000276:immunology*; D009439:Neuraminidase; D012204:Rh-Hr Blood-Group System / Q000276:immunology*
D000017:ABO Blood-Group System; D000906:Antibodies; D006388:Hemagglutinins; D012204:Rh-Hr Blood-Group System; D009439:Neuraminidase; D005690:Galactose
Mise en évidence d'une augmentation anormale du titre de l'hémagglutinine anti-T au cours du paludisme humain.