HLA antigens in a family with both parents and several siblings affected by Graves' disease.
A family with autoimmune thyroid disease is described. Four members had Graves' disease and 3 had diffuse goitres. Both parents (second cousins) carry the HLA haplotype: HLA Aw24, Bw39(w6), Cw-, DR3, MT2. Only females with this haplotype show thyroid symptoms. These findings emphasize the involvement of HLA linked genes in susceptibility to Graves' disease.
D000293:Adolescent; D000328:Adult; D005260:Female; D005802:Genes, MHC Class II; D006111:Graves Disease / Q000235:genetics* / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D015803:HLA-DR3 Antigen; D006238:Haploidy; D006801:Humans; D008297:Male
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D015803:HLA-DR3 Antigen