[Acute positive Tdt leukemia with megakaryoblastic involvement. Apropos of an observation of an infant].
After observation of a 10 month-old infant hospitalised for acute thrombopenia associated with signs of marked radiological hyperostosis, the initial medullograms showed a rich bone marrow free of blast cells. Subsequent complications of the thrombopenia were anemia, neutropenia and circulating blastosis. Marrow aspirations at various sites were unsuccessful. X-rays showed a worsening of the conditions and the child suffers attacks of intense pain. Ultrastructural cytochemistry and Tdt disclosed by immunofluorescence showed that the majority of blasts possessed Tdt and 2-3% were PPO positive. The presence of these 2 markers may correspond either to the presence of a promegakaryoblastic leukemia with aberrant Tdt, or to the coexistence of 2 types of blasts cells.
D000208:Acute Disease; D001854:Bone Marrow Cells; D001842:Bone and Bones / Q000000981:diagnostic imaging; D004253:DNA Nucleotidylexotransferase / Q000032:analysis*; D004254:DNA Nucleotidyltransferases / Q000032:analysis*; D005455:Fluorescent Antibody Technique; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000097:blood / Q000201:enzymology; D008297:Male; D008533:Megakaryocytes / Q000648:ultrastructure; D011859:Radiography; D013920:Thrombocythemia, Essential / Q000097:blood / Q000201:enzymology*
D004254:DNA Nucleotidyltransferases; D004253:DNA Nucleotidylexotransferase
Leucémie aiguë TdT positive avec participation mégacaryoblastique. A propos d'une observation faite chez le nourrisson.