An immune response gene linked to MHC in man.
With a view to finding a relationship between immune response and MHC in man, 83 D negative mothers with allo-into-D antibodies and 26 PLA1 negative mothers with allo-anti-PLA1 antibodies were investigated as regards their HLA-A, B and DR antigens. We have found that there is a highly significant relation between the DR3 antigen and an immune response to the PLA1 antigen, but none to the D antigen.
D005787:Gene Frequency; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D006801:Humans; D008285:Major Histocompatibility Complex
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens