Intrathecal morphine for postoperative pain relief in children.
Intrathecal morphine was given to 56 children undergoing open-heart surgery. The first 27 patients received 0.03 mg kg-1 and the other 29 received 0.02 mg kg-1. Satisfactory postoperative analgesia, lasting for 22 h or longer, was obtained in over 60% of the patients in each group. Respiratory depression occurred in six of the first group (0.03 mg kg-1), and three in the second (0.02 mg kg-1), most frequently between 3.5 and 4.5 h after the administration of the intrathecal morphine.
D000293:Adolescent; D002245:Carbon Dioxide / Q000097:blood; D006348:Cardiac Surgical Procedures; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D006801:Humans; D007223:Infant; D007278:Injections, Spinal; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy*; D011183:Postoperative Complications; D012131:Respiratory Insufficiency / Q000139:chemically induced; D013997:Time Factors
D002245:Carbon Dioxide; D009020:Morphine