HLA antigens in Japanese patients with primary biliary cirrhosis and autoimmune hepatitis.
22 Japanese patients with primary biliary cirrhosis and 12 patients with autoimmune hepatitis were studied for HLA antigens. In the patients with primary biliary cirrhosis, HLA-DR2 showed a statistically higher frequency compared to the controls (68 versus 30%, chi 2 corr. = 7.660, p less than 0.007, p corr. less than 0.042, RR = 5.00). In the patients with autoimmune hepatitis, HLA-A10 showed a somewhat higher frequency compared to the controls (50 versus 19%, chi 2 corr. = 4.824, p less than 0.05, p corr. NS, RR = 4.36). In the DR locus, DR2 and DR4 showed tendencies toward increased frequency, but these were not statistically significant.
D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology*; D005260:Female; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D006505:Hepatitis / Q000235:genetics / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007564:Japan; D008105:Liver Cirrhosis, Biliary / Q000235:genetics / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010641:Phenotype
D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II