Metabolism of malonic semialdehyde in man.
Malonic semialdehyde is formed in the alternative pathway of propionate metabolism and in the catabolism of beta-alanine. Studies of these pathways in cultured cells from a patient with mitochondrial malonyl-CoA decarboxylase deficiency indicate that malonic semialdehyde is directly converted into acetyl-CoA in man.
D000105:Acetyl Coenzyme A / Q000378:metabolism; D000214:Acyl Coenzyme A / Q000378:metabolism; D000409:Alanine / Q000378:metabolism; D002245:Carbon Dioxide / Q000378:metabolism; D002262:Carboxy-Lyases / Q000172:deficiency / Q000378:metabolism; D002460:Cell Line; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism; D008314:Malonates / Q000378:metabolism*; D008315:Malondialdehyde / Q000031:analogs & derivatives / Q000378:metabolism*; D008316:Malonyl Coenzyme A / Q000378:metabolism; D008928:Mitochondria / Q000201:enzymology; D010084:Oxidation-Reduction
D000214:Acyl Coenzyme A; D008314:Malonates; D002245:Carbon Dioxide; C009061:propionyl-coenzyme A; D008315:Malondialdehyde; D008316:Malonyl Coenzyme A; D000105:Acetyl Coenzyme A; C039786:malonic semialdehyde; D002262:Carboxy-Lyases; C021532:malonyl-CoA decarboxylase; D000409:Alanine