[Autoradiographic studies on the protective effect of mesna in the urinary bladder mucosa of the rat during administration of cyclophosphamide (preliminary communication)].
Cyclophosphamide (100 mg/kg i.p.) produces severe bladder lesions in rats and induces an intense regeneration of the urothelium which can be followed up by 3H-thymidine incorporation. Simultaneously administered mesna (100 mg/kg i.v.) prevents these bladder lesions and no increased regeneration with 3H-thymidine incorporation can be observed.
D000818:Animals; D001345:Autoradiography; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors* / Q000633:toxicity; D005260:Female; D008623:Mercaptoethanol / Q000031:analogs & derivatives*; D015080:Mesna / Q000494:pharmacology*; D009092:Mucous Membrane / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013936:Thymidine / Q000378:metabolism; D001743:Urinary Bladder / Q000187:drug effects*; D001745:Urinary Bladder Diseases / Q000517:prevention & control
D008623:Mercaptoethanol; D003520:Cyclophosphamide; D015080:Mesna; D013936:Thymidine
Autoradiographische Untersuchungen zur protektiven Wirkung von Mesna an der Harnblasenschleimhaut der Ratte bei Applikation von Cyclophosphamid (Vorläufige Mitteilung).