[What does the minimal inhibitory concentration of an antibiotic hide from the clinician? Experimental examples].
Examples are presented to demonstrate that in-vitro determinations of the minimal inhibitory concentration of antibiotics do not take into account factors of presumable in-vivo significance: pH and divalent cations in the medium, protein binding of antimicrobials, and the bacterial inoculum effect.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001390:Azlocillin; D001419:Bacteria / Q000187:drug effects*; D002118:Calcium / Q000097:blood; D002937:Cinoxacin / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008274:Magnesium / Q000097:blood; D009254:Nafcillin / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology; D011485:Protein Binding; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012709:Serum Albumin / Q000032:analysis; D013210:Staphylococcus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D010406:Penicillins; D012709:Serum Albumin; D009254:Nafcillin; D001390:Azlocillin; D008274:Magnesium; D002937:Cinoxacin; D002118:Calcium
Was verbirgt die minimale Hemmkonzentration eines Antibiotikums dem Kliniker? Experimentelle Beispiele.