Influence of naloxone on the captopril-induced decrease in vagal pressor reflexes.
The effects of intracisternal injection of captopril (0.3 mg/kg) on the pressor responses elicited by afferent stimulation of the vagus were investigated in the anaesthetized dog. The captopril-induced decrease in the systolo-diastolic pressor response to vagal stimulation was reversed by subsequent injection of naloxone (0.1 mg/kg, i.v.). These results suggest the involvement of central opioid mechanisms in the hypotensive properties of captopril.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology*; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D011392:Proline / Q000031:analogs & derivatives*; D014630:Vagus Nerve / Q000502:physiology*
D009270:Naloxone; D011392:Proline; D002216:Captopril