Treatment of hypothalamic infertility with pulsatile GN-RH administration.
In this study the Authors have obtained an ovulatory response using intravenous Gn-RH treatment in four patients with hypothalamic hypogonadotropic amenorrhea. The Gn-RH was administered in a pulsatile manner with a small portable autoinfusion pump (Autosyringe, Inc., Hooksett). The ovarian follicular maturation, as it appears from the pelvic echography, was perfectly similar to that observed in a spontaneous ovulatory cycle. Endocrine picture by serial determination of gonadotropin; prolactin, estradiol and progesterone concentrations showed hormone values to be in the normal range. During the therapy no complications were observed; at the present time no pregnancy has occurred.
D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007263:Infusions, Parenteral / Q000295:instrumentation; D010062:Ovulation Induction / Q000379:methods
D007987:Gonadotropin-Releasing Hormone