Gastric acid secretion and duodenal ulcer healing during treatment with omeprazole. A Scandinavian Multicentre Study.
Twenty-seven duodenal ulcer patients were treated with omeprazole, 40 mg daily for 4 weeks. The peak acid output to pentagastrin measured 24 h after dosing was reduced by 54% on day 3 of the study and by 74% on day 14. The ulcers in 25 of 26 patients had healed by the end of the treatment period, and 1 patient was unable to attend the final endoscopy. Ulcer symptoms were relieved rapidly. The drug was well tolerated, and few adverse reactions were reported.
D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004381:Duodenal Ulcer / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole; D012636:Secretory Rate / Q000187:drug effects
D000897:Anti-Ulcer Agents; D001562:Benzimidazoles; D009853:Omeprazole