Chromosomal aberrations in a case of T-cell CLL with concomitant IgA myeloma.
Four consistent markers, involving chromosomes 8, 11, 14, 18, 21 and 22, were found in the majority of metaphases obtained after stimulation of peripheral blood and bone marrow from a patient with a T-cell chronic lymphocytic leukemia (CLL) and a concomitant IgA/lambda myeloma with phytohemagglutinin (PHA), lipopolysaccharide of E. coli (LPS) and S. aureus strain Cowan I bacteria (Cowan). A second malignant clone with three additional markers was observed after stimulation with Concanavalin A (Con A). A chromosome 14 aberration, inv(14) (q11-q32), may be of significance in the T-cell malignancy and may suggest a common clonal origin of the two tumors.
D000368:Aged; D002869:Chromosome Aberrations; D002901:Chromosomes, Human, 13-15; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000648:ultrastructure*; D008934:Mitogens / Q000494:pharmacology; D009101:Multiple Myeloma / Q000276:immunology / Q000648:ultrastructure*; D009378:Neoplasms, Multiple Primary; D013601:T-Lymphocytes / Q000648:ultrastructure*
D007070:Immunoglobulin A; D007146:Immunoglobulin lambda-Chains; D008934:Mitogens