Safracins, new antitumor antibiotics. I. Producing organism, fermentation and isolation.
Safracins, new antibiotics with a novel skeleton, were discovered in a culture broth of Pseudomonas sp. The producing organism has been identified as Pseudomonas fluorescens. Safracins A and B were isolated by ethyl acetate extraction and chromatography on silica gel.
D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification*; D050260:Carbohydrate Metabolism; D003470:Culture Media; D005285:Fermentation; D007546:Isoquinolines / Q000096:biosynthesis / Q000302:isolation & purification; D007700:Kinetics; D009584:Nitrogen / Q000378:metabolism; D011551:Pseudomonas fluorescens / Q000145:classification / Q000254:growth & development*; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D007546:Isoquinolines; C039866:safracin A; C039865:safracin B; D009584:Nitrogen