[Somatocrinin (GRF) stimulates the liberation of biologically active somatotropin (GH) in adult man].
Intravenous injection of four doses (75, 150, 300, 600 micrograms) of synthetic somatocrinin (GRF 44) greatly increases serum growth hormone concentrations in ten adult normal men in contrast to placebo. Mean peak values were identical. Plasma GH released under GRF stimulation was able to stimulate proliferation of NB2 cells.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D013007:Growth Hormone-Releasing Hormone; D006801:Humans; D007700:Kinetics; D008297:Male; D010446:Peptide Fragments; D010919:Placebos
D010446:Peptide Fragments; D010919:Placebos; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone
La somatocrinine (GRF) provoque la libération de Somathormone (GH) biologiquement active chez l'Homme adulte.