Comparative study of 3 aminoglycoside antibiotics and aztreonam on M.I.F. production by splenic lymphocytes of mice in vitro.
The aminoglycosides gentamicin, tobramycin, netilmicin and aztreonam were tested for their effects on migration inhibition factor production by mouse lymphocytes challenged by phytohemagglutinin in vitro. The three aminoglycosides were found to depress its production while aztreonam was devoid of this depression effect.
D000617:Aminoglycosides / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001398:Aztreonam; D066298:In Vitro Techniques; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis*; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D008222:Lymphokines / Q000096:biosynthesis*; D051379:Mice; D010586:Phagocytes / Q000187:drug effects; D013154:Spleen / Q000276:immunology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines; D001398:Aztreonam