Diazepam-induced release of behavior in an extinction procedure: its reversal by Ro 15-1788.
The effects of the benzodiazepine receptor antagonist Ro 15-1788, an imidazobenzodiazepine derivative, were studied with respect to three pharmacological activities exerted by diazepam in rats. Two of these, release of shock-induced suppression of drinking and attenuation of non-reward-induced cessation of responding for food, reflect the anxiolytic property of benzodiazepines. The amnesic-like effect of diazepam was also investigated. Ro 15-1788 (in doses ranging from 4 to 16 mg/kg p.o.) completely reversed diazepam (2 mg/kg)-induced release of behavior in both punishment and non-reward procedures. In contrast, Ro 15-1788 reduced but did not completely abolish diazepam-induced amnesia. These data suggest that the anticonflict and anti-frustration effects of benzodiazepines probably involve similar receptor types which nevertheless differ from those chiefly implicated in the amnesic-like activity of benzodiazepines.
D000647:Amnesia / Q000139:chemically induced; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001570:Benzodiazepinones / Q000494:pharmacology*; D003975:Diazepam / Q000037:antagonists & inhibitors*; D004326:Drinking / Q000187:drug effects; D005108:Extinction, Psychological / Q000187:drug effects*; D005442:Flumazenil; D006801:Humans; D011678:Punishment; D051381:Rats
D001570:Benzodiazepinones; D005442:Flumazenil; D003975:Diazepam