[Effect of electric stimulation of the dentate nucleus on focal complexes of epileptic activity in the cerebral cortex].
Acute experiments on cats were made with the use of an experimental multifocal epileptic complex (MEC) which was created by local application of different concentrations of penicillin to different zones of the neocortex. At the early stages of the MEC the epileptic activity in the seizure foci increased during electrical stimulation (ES, 100-300 Hz) of the contralateral dentate nucleus. As the epileptic activity of the MEC descended up to the disappearance of some of the dependent foci, ES elicited the suppression of the epileptic discharges in the remaining foci. ES of the dentate nucleus did not affect the overall duration of MEC existence. It is inferred that the dentate nucleus belongs to the antiepileptic system of the brain.
D000818:Animals; D002415:Cats; D002529:Cerebellar Nuclei / Q000187:drug effects / Q000502:physiology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology*; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D004828:Epilepsies, Partial / Q000139:chemically induced / Q000503:physiopathology*; D009433:Neural Inhibition / Q000187:drug effects; D010406:Penicillins / Q000494:pharmacology
D010406:Penicillins
Vliianie élektricheskoĭ stimuliatsii zubchatogo iadra na kompleksy ochagov épilepticheskoĭ aktivnosti v kore golovnogo mozga.