[Effect of preliminary treatment with homologous interferon (priming) on the production of human immune interferon].
Pretreatment of the cultures of human peripheral blood leukocytes and splenocytes with the incubation medium of the mitogen-stimulated human lymphoid cells containing various concentrations of lymphokines (including 10 to 1280 units/ml of immune interferon) resulted in increased (by at least 4 times) production of interferon, induced by staphylococcal enterotoxin A, phytohemagglutinin and mitogen from Phytolacca americana (PWM), as well as in intensification of DNA synthesis in the producing cells. A more pronounced specific binding of the inductor labeled with radioactive iodine to the producing cells was also observed.
D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D005347:Fibroblasts / Q000276:immunology; D006801:Humans; D007369:Interferon Inducers / Q000494:pharmacology*; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000494:pharmacology*; D007962:Leukocytes / Q000276:immunology; D008222:Lymphokines / Q000494:pharmacology; D008934:Mitogens / Q000494:pharmacology; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013997:Time Factors
D007369:Interferon Inducers; D008222:Lymphokines; D008934:Mitogens; D007371:Interferon-gamma; D004247:DNA
Vliianie predvaritel'noĭ obrabotki gomologichnym interferonom (praĭming) na produktsiiu chelovecheskogo immunnogo interferona.