Optimal iodine concentration in digital subtraction arteriography.
The effects of two different concentrations of the contrast agent Hexabrix were evaluated in a total of 26 patients undergoing cerebral angiography and randomly assigned to two groups. Injection volume, rate, and iodine concentration were constant. Carotid digital exams using 8% and 12% Hexabrix in the same patient showed the higher concentration was preferred for vessels of all sizes. In comparing 12% and 16% concentrations of Hexabrix, there was again a preference for the higher concentration, although results were not statistically significant. Both 12% and 16% Hexabrix in carotid studies resulted in excellent quality exams. Vessel see-through ability was somewhat better with 12% Hexabrix. Subjective symptoms of all patients during the injection were minimal or absent. Hexabrix is theoretically more attractive than conventional agents in that optimal concentration for digital imaging is in a range which is iso-osmotic with serum.
D000703:Analog-Digital Conversion; D002533:Cerebral Angiography / Q000379:methods*; D003287:Contrast Media / Q000008:administration & dosage*; D006801:Humans; D007463:Iodobenzoates / Q000008:administration & dosage*; D007485:Ioxaglic Acid; D013382:Subtraction Technique; D014283:Triiodobenzoic Acids / Q000008:administration & dosage*
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D007485:Ioxaglic Acid