[The importance of increased prostaglandins and prostacyclin for the effect of oxyfedrin in isolated guinea pig heart preparations].
In isolated perfused heart preparations of guinea pigs coronary dilating and positive inotropic doses of oxyfedrine induce a significant increase of the release of prostaglandin-like substances (PLS) and prostacyclin (PGI2). Indometacin as an inhibitor of prostaglandin biosynthesis (140 mumol/l) enhances after a 10 min lasting perfusion contraction force and coronary flow of the hearts but inhibits PGI2-formation. Under these conditions oxyfedrine loses its positive influence on inotropism, coronary flow and PGI2-efflux. Indometacin (140 mumol/l) also completely abolishes the increase of cardiac performance of isolated auricle preparations by oxyfedrine (50 mumol/l). These findings agree with former results and indicate an involvement of the PLS- and PGI2-biosynthesis in the antianginal efficacy of oxyfedrine.
D000818:Animals; D011464:Epoprostenol / Q000494:pharmacology*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D010099:Oxyfedrine / Q000494:pharmacology*; D011427:Propiophenones / Q000494:pharmacology*; D011453:Prostaglandins / Q000494:pharmacology*
D011427:Propiophenones; D011453:Prostaglandins; D011464:Epoprostenol; D010099:Oxyfedrine; D007213:Indomethacin
Zur Bedeutung einer vermehrten Freisetzung von Prostaglandinen und Prostazyklin für die Wirksamkeit von Oxyfedrin an isolierten Herzpräparaten des Meerschweinchens.