Ethanol clearance in nine inbred rat strains.
The rate of ethanol disappearance was determined for each of eight inbred rat strains and the N/Nih line of heterogeneous rats. There are significant differences in ethanol elimination rates in the strains tested. Females have rates significantly different from those of males in five of the eight inbred strains and in the N/Nih line. Castration of males alters the rate of elimination only in the F344/N strain.
D000818:Animals; D003433:Crosses, Genetic; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D005838:Genotype; D007274:Injections, Intraperitoneal; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol