Initiation of gonadotropin responsiveness in hypothalamic hypogonadism: comparison of pulsatile and continuous nocturnal subcutaneous administration of LH-RH.
An enhanced secretion of LH and FSH was observed in two patients with hypothalamic hypogonadism following treatment with nocturnal s.c. administration of LH-RH. Using portable infusion pumps two forms of therapy were used for 9 nights with a two months interval in between: A) continuous nocturnal s.c. LH-RH; B) pulsatile nocturnal s.c. LH-RH with administration of a bolus dose at 90 min intervals. Both therapeutical regimens induced a rise in the 8:00 h concentrations of LH. The secretory response of LH during an infusion of LH-RH (200 micrograms i.v.; t = 4 hours) was increased after both forms of therapy, whereas FSH secretion was enhanced only after the pulsatile mode of LH-RH application.
D000293:Adolescent; D000328:Adult; D004334:Drug Administration Schedule; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007006:Hypogonadism / Q000188:drug therapy*; D007031:Hypothalamus / Q000503:physiopathology*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone