[Dynamics of the frequencies of chemically induced sister chromatid exchanges in a series of cell generations].
The number of sister chromatid exchanges (SCE) in a culture of human lymphocytes and the established cultures of Chinese hamster cells has been studied after the exposure to thiophosphamide and dipin at different stages of the cell cycle. The most pronounced effect is observed under the action of the mutagens at the G1 of the first cycle, prior to harvest. The SCE level becomes lower with the increase of the interval between the exposure to the mutagen and the time of 5-BUdR introduction. The number of SCEs per cell drops to the control level when the duration of the first interval is equal to that of the cell cycle. The results obtained prove the mutagen-induced impairments causing SCE formation to be repaired practically 100%, provided that at least one cycle of DNA replication took place.
D000477:Alkylating Agents / Q000494:pharmacology; D000818:Animals; D001388:Aziridines / Q000494:pharmacology; D001973:Bromodeoxyuridine / Q000494:pharmacology; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D003434:Crossing Over, Genetic / Q000187:drug effects*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008934:Mitogens / Q000494:pharmacology; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013852:Thiotepa / Q000494:pharmacology; D013997:Time Factors
D000477:Alkylating Agents; D001388:Aziridines; D008934:Mitogens; D013852:Thiotepa; D001973:Bromodeoxyuridine; C007526:dipin
Dinamika chastot khimicheski indutsiorvannykh sestrinskikh khromatidnykh obmenov v riadu kletochnykh pokoleniĭ.