Discriminative stimulus properties of phenytoin in the pigeon.
Pigeons trained under a two-key drug discrimination procedure eventually learned to discriminate 5 mg/kg phenytoin from saline injections. When 1.25-20 mg/kg doses of phenytoin were substituted for the training dose, the percentage of responses directed to the phenytoin-appropriate key varied directly with dose. Chlorpromazine, d-amphetamine, diazepam, and phenobarbital failed to produce phenytoin-like patterns of responding.
D000818:Animals; D010856:Columbidae; D004192:Discrimination, Psychological / Q000187:drug effects*; D004347:Drug Interactions; D010672:Phenytoin / Q000494:pharmacology*; D012055:Reinforcement Schedule
D010672:Phenytoin