[Action of bioglycans from marine invertebrates on macrophage functioning].
The data on the absorption and bactericidal function of macrophages are presented. It was shown in vivo that bioglycans 42 and 106 had a stimulating action on phagocytosis of Y. pseudotuberculosis and S. typhimurium capable of persisting in macrophages for prolonged periods. Addition of the bioglycans to the cultures of the macrophages from intact animals increased the absorption activity of the macrophages and somewhat potentiated their bactericidal activity. Under the action of the bioglycans the level and rate of the carbon clearance in the blood flow increased. The results of the study are promising for adequate control of infections caused by intracellularly located pathogens.
D000042:Absorption; D000818:Animals; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007448:Invertebrates; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D008386:Marine Biology; D051379:Mice; D008808:Mice, Inbred CBA; D010587:Phagocytosis / Q000187:drug effects; D011134:Polysaccharides / Q000494:pharmacology*; D012486:Salmonella typhimurium; D013997:Time Factors; D015007:Yersinia
D011134:Polysaccharides
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