Inhibition of histidine decarboxylase and tumour promoter-induced arachidonic acid release by lecanoric acid analogues.
Lecanoric acid analogues containing benzanilide structure inhibited histidine decarboxylase and arachidonic acid release from the cell membrane phospholipids induced by a tumour promoter, 12-O-tetradecanoylphorbol-13-acetate. But they did not inhibit cellular binding of phorbol-12,13-dibutylate. Lecanoric acid analogues also inhibited prostaglandin synthetase and delayed-type hypersensitivity responses against sheep red blood cells in mice. Thus, lecanoric acid analogues antagonized several enzymic and cellular effects of the tumour promoter.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D001549:Benzamides / Q000494:pharmacology*; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002478:Cells, Cultured; D004622:Embryo, Mammalian; D005260:Female; D006640:Histidine Decarboxylase / Q000037:antagonists & inhibitors*; D007700:Kinetics; D008563:Membrane Lipids / Q000378:metabolism*; D051379:Mice; D010704:Phorbols / Q000494:pharmacology*; D010743:Phospholipids / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D012459:Salicylates / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D001095:Arachidonic Acids; D001549:Benzamides; D008563:Membrane Lipids; D010704:Phorbols; D010743:Phospholipids; D012459:Salicylates; D016718:Arachidonic Acid; C008263:lecanoric acid; D002262:Carboxy-Lyases; D006640:Histidine Decarboxylase; D013755:Tetradecanoylphorbol Acetate