New hormonal treatment in cancer of the prostate: combined administration of an LHRH agonist and an antiandrogen.
At doses which have no or minimal inhibitory effect when administered alone, the LHRH agonist [D-Ser(TBU)6,des-Gly-NH10(2)] LHRH ethylamide (HOE-766) and the antiandrogen RU-23908 administered simultaneously cause a marked inhibition of ventral prostate and seminal vesicle weight after 5 months of treatment. The effect of the LHRH agonist is due to a blockage of the testicular steroidogenic pathway. The same LHRH agonist administered to adult men with cancer of the prostate causes a marked inhibition of serum testosterone and dihydrotestosterone to castration levels within 1-2 weeks. Administration of the pure antiandrogen to men with cancer of the prostate already receiving the LHRH agonist does not interfere with the LHRH agonist-induced blockage of androgen biosynthesis: Moreover, objective signs of remission of the disease were rapidly observed in 8 out of 10 patients. The ease of application of this new form of hormonal therapy which neutralizes androgens from all sources should facilitate its early administration and thus minimize the development of metastases and androgen-resistant cell clones.
D000726:Androgen Antagonists / Q000627:therapeutic use*; D000818:Animals; D002064:Buserelin; D002369:Castration; D013196:Dihydrotestosterone / Q000097:blood; D004359:Drug Therapy, Combination; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D006728:Hormones / Q000627:therapeutic use*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use* / Q000633:toxicity; D048289:Imidazolidines; D008297:Male; D011467:Prostate / Q000187:drug effects*; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects; D013739:Testosterone / Q000097:blood
D000726:Androgen Antagonists; D006728:Hormones; D007093:Imidazoles; D048289:Imidazolidines; D013196:Dihydrotestosterone; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; C021277:nilutamide; D002064:Buserelin