Comparative study of clearance of 10% and 20% fat emulsion.
The rate of fat emulsion clearance from the blood of 10 healthy adult male volunteers administered 0.1 gram of fat per kilogram body weight as 10% or 20% safflower oil emulsion (Liposyn) was studied. The subjects were hospitalized for 2 days and each was given the predetermined amount of one of the two fat emulsions (10% or 20%) by rapid injection into a peripheral vein and the rate of clearance of the emulsion determined over a 60-minute period, beginning when half of the emulsion had been injected. There was no significant difference in the clearance rate between the two emulsions. It is concluded that 20% fat emulsion is a safe as 10% fat emulsion for use in intravenous nutritional support.
D000328:Adult; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006207:Half-Life; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008657:Metabolic Clearance Rate; D010288:Parenteral Nutrition
D005217:Fat Emulsions, Intravenous; D005230:Fatty Acids, Nonesterified; D008055:Lipids