[Diagnosis of benign and malignant tumors of the female breast using single photon emission computed tomography with 99mTc-DTPA].
31 patients with suspicious findings on mammographic films were examined preoperatively by single photon emission computed tomography. A scintigraphic study was performed at 30 and 120 min after i.v. administration of 370 MBq (10 mCi) 99mTc-DTPA. The radionuclide accumulation in both breasts was analyzed quantitatively on transaxial slices using the ROI-technique. In benign lesions (n = 12) as well as in carcinomas (n = 19), an increased 99mTc-DTPA accumulation was found as compared to clinically and radiographically unaffected sides. A radionuclide accumulation exceeding 20% of the contralateral side was considered to indicate malignancy. Thus the sensitivity in diagnosing malignant tumours was 74%, the specificity 64% and the accuracy 70%. In contrast to studies with planar scintigraphic imaging techniques the results clearly show an increased 99mTc-DTPA uptake even in benign breast lesions.
D001943:Breast Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D004369:Pentetic Acid; D013667:Technetium; D016284:Technetium Tc 99m Pentetate; D014055:Tomography, Emission-Computed
D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate
Diagnostik benigner und maligner Tumoren der weiblichen Brust durch die Single Photon Emissions-Computertomographie mit 99mTc-DTPA.