[Reversible acquired acanthocytosis and hemolytic anemia associated with hypobetalipoproteinemia in a chronic alcoholic].
A 38-year-old male chronic alcoholic developed spur-cell anemia during an episode of non-A, non-B hepatitis. Lipid evaluation showed a marked decrease in cholesterol (1.98 mmol/l), in triglycerides (0.41 mmol/l) and in phospholipids (1.38 mmol/l) in total serum as well as in VLDL and LDL. Serum apolipoprotein B was also low. Cholesterol (C) and phospholipid (PH) content of the erythrocytic membrane was increased, as was the intraerythrocytic C/PH ratio. Hemolysis ceased with correction of the hypobetalipoproteinemia. The relationship between acquired acanthocytosis and lipid disorders is discussed.
D000050:Acanthocytes / Q000473:pathology*; D000328:Adult; D000437:Alcoholism / Q000097:blood / Q000150:complications*; D000743:Anemia, Hemolytic / Q000097:blood / Q000150:complications*; D002784:Cholesterol / Q000097:blood; D004910:Erythrocyte Membrane / Q000032:analysis; D004913:Erythrocytes, Abnormal / Q000473:pathology*; D006526:Hepatitis C / Q000097:blood / Q000150:complications*; D006525:Hepatitis, Viral, Human / Q000150:complications*; D006801:Humans; D006995:Hypobetalipoproteinemias / Q000097:blood / Q000150:complications*; D007009:Hypolipoproteinemias / Q000150:complications*; D008297:Male; D010743:Phospholipids / Q000097:blood
D010743:Phospholipids; D002784:Cholesterol
Acanthocytose acquise et anémie hémolytique réversibles associées à une hypobétalipoprotéinémie chez un alcoolique chronique.