[Long-term course of type I-simulating type II-diabetes mellitus].
In only few cases of primarily non- insulin-dependent diabetes mellitus after many years an absolute insulin dependency can develop. Within 5000 patients of a diabetic outpatient clinic in 2 years this happened in 21 patients. These patients offered a C-peptide-secretion after stimulation which was typical for an insulin dependent diabetes. The investigation of HLA-frequencies showed a marked increase of the DR 3 und DR 4 loci. These results demonstrate that obviously the genetically as type I characterized diabetes may appear clinically in the picture of type II-diabetes for many years. This must be taken in consideration in therapeutic or epidemiologic questions.
D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000175:diagnosis*; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male
D001786:Blood Glucose; D002096:C-Peptide; D006680:HLA Antigens; D007328:Insulin
Langjähriger Verlauf des Typ-I-unter dem klinischen Bild des Typ II-Diabetes mellitus.