Positron emission tomographic studies of aging and Alzheimer disease.
In this study the positron emission tomographic (PET)-18F-2-deoxy-2-fluoro-D-glucose (FDG) technique was used to study both normal aging and senile dementia. The results derived from 15 young normal subjects (mean age, 26 +/- 5 years) and 22 elderly normal subjects (mean age, 66 +/- 7 years) failed to indicate significant metabolic changes associated with age. A group of 24 patients with senile dementia (mean age, 73 +/- 7 years) showed consistent diminutions in regional glucose use relative to the elderly normals. Across all brain regions the diminutions were 17%-24%. There were also significant correlations between the measures of glucose use and the measures of cognitive functioning. Discriminant function classification analysis results indicate that better than 80% classification accuracy can be achieved for individual PET measures. These data suggest a possible future diagnostic use of PET in senile dementia.
D000328:Adult; D000368:Aged; D000375:Aging; D000544:Alzheimer Disease / Q000097:blood / Q000000981:diagnostic imaging*; D001786:Blood Glucose / Q000378:metabolism; D003704:Dementia / Q000097:blood / Q000000981:diagnostic imaging*; D003847:Deoxyglucose / Q000031:analogs & derivatives; D019788:Fluorodeoxyglucose F18; D006801:Humans; D008875:Middle Aged; D014055:Tomography, Emission-Computed / Q000379:methods*
D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose