Characterization of a calici-like virus (Newbury agent) found in association with astrovirus in bovine diarrhea.
A bovine calici-like virus and astrovirus, present in the same fecal sample from an outbreak of diarrhea, were separated from each other by calf passage. The calici-like virus (Newbury agent SRV-1) caused anorexia, diarrhea, and xylose malabsorption in gnotobiotic calves aged 17 to 60 days, whereas the bovine astrovirus was nonpathogenic in similar calves. The calici-like virus was shown to be antigenically distinct from a previously described isolate (Newbury agent SRV-2) by two-way cross-protection experiments in calves; calves immune to homologous challenge became clinically ill and excreted virus when challenged with the heterologous virus.
D000818:Animals; D002139:Caliciviridae / Q000276:immunology / Q000302:isolation & purification* / Q000648:ultrastructure; D002417:Cattle; D002418:Cattle Diseases / Q000382:microbiology*; D003967:Diarrhea / Q000382:microbiology / Q000662:veterinary*; D005455:Fluorescent Antibody Technique; D001257:Mamastrovirus / Q000276:immunology / Q000302:isolation & purification* / Q000648:ultrastructure; D008854:Microscopy, Electron; D014777:Virus Diseases / Q000382:microbiology / Q000662:veterinary*; D014713:Viruses, Unclassified / Q000302:isolation & purification*