[Detection of carbonic anhydrase in the human kidney from the viewpoint of acid-base regulation (an immunohistochemical study in urolithiasis patients)].
The enzyme carbonic anhydrase was detected with an indirect immunoperoxidase method in 22 kidney exploratory excisions of patients with urolithiasis, ren mobilis or stenosis of ureteral pelvic junction. The reactivity of carbonic anhydrase was related to disturbances in acid-base equilibrium. Carbonic anhydrase was detected in the convoluted parts of the distal tubules, connecting tubules and cortical collecting ducts. The distribution corresponds vastly with the localization of intercalated cells. The reaction was increased in three cases with acid rigidity and was strongly reduced in one case of renal tubular acidosis.
D000136:Acid-Base Equilibrium; D000141:Acidosis, Renal Tubular / Q000201:enzymology; D000328:Adult; D000368:Aged; D002256:Carbonic Anhydrases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007669:Kidney Calculi / Q000201:enzymology*; D007684:Kidney Tubules / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D014517:Ureteral Obstruction / Q000201:enzymology
D002256:Carbonic Anhydrases
Der Nachweis von Carboanhydrase in der menschlichen Niere unter dem Aspekt der Säure-Basen-Regulation (Eine immunhistochemische Untersuchung bei Urolithiasis-Patienten).