Modulation by propranolol of the lysyl cross-links in aortic elastin and collagen of the aneurysm-prone turkey.
dl-Propranolol (propranolol) fed to immature and mature aneurysm-prone turkeys (Broad-Breasted White, BBW) for 6 weeks significantly raised the tensile strength of tissue rings from the abdominal aorta. The drug-mediated increase in tensile strength values was dose-related and independent of its heart rate- and arterial pressure-lowering effects. Propranolol acts, in part, by (a) stimulating lysyl oxidase to produce greater amounts of reactive aldehydes for intermolecular cross-links, (b) enhancing the progression of chemically unstable to stable forms of intermolecular elastin cross-links (lysinonorleucine and the desmosines), and (c) reducing the density of the age-related intermolecular cross-linking of collagen (pyridinoline). These propranolol effects on the lysyl cross-links were demonstrated in both the immature and mature animals and suggest a heretofore unrecognized potential for this widely used cardiovascular drug.
D000783:Aneurysm / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D001012:Aorta, Abdominal / Q000378:metabolism; D001158:Arteries / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects; D003094:Collagen / Q000378:metabolism*; D004549:Elastin / Q000378:metabolism*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008239:Lysine / Q000378:metabolism*; D011433:Propranolol / Q000494:pharmacology*; D013718:Tensile Strength; D014422:Turkeys
D003094:Collagen; D004549:Elastin; D011433:Propranolol; D008239:Lysine