Diabetic hypertriglyceridaemia and related 5' flanking polymorphism of the human insulin gene.
A polymorphic DNA sequence was studied on the 5' flanking region of the human insulin gene in relation to diabetic lipaemia. The genotype frequencies in a control population (n = 52) were homozygous L 6%, heterozygous 54%, and homozygous S 40%. Corresponding genotype frequencies in a hypertriglyceridaemic group (n = 74) were 18%, 66%, and 16% (p less than 0.01; chi 2 test). When the hypertriglyceridaemic patients were divided on the basis of glucose tolerance the corresponding genotype frequencies in the diabetic subgroup (n = 23) were 39%, 52%, and 9% compared with 0%, 74%, and 26% in the non-diabetics (n = 34) (p less than 0.001; chi 2 test). These findings suggest that the homozygous L genotype may confer susceptibility to diabetic hypertriglyceridaemia.
D000328:Adult; D000368:Aged; D000483:Alleles; D001345:Autoradiography; D004247:DNA / Q000235:genetics; D003920:Diabetes Mellitus / Q000235:genetics*; D005260:Female; D005796:Genes; D005838:Genotype; D006801:Humans; D006824:Hybridization, Genetic; D006951:Hyperlipoproteinemias / Q000150:complications / Q000235:genetics*; D007328:Insulin / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D011110:Polymorphism, Genetic
D007328:Insulin; D004247:DNA