Histopathology of experimental systemic candidosis in guinea-pigs.
Unpretreated Albino guinea-pigs were infected intravenously with Candida albicans. Cutaneous candidosis with (pseudo-) hyphal outgrowth in the hair shafts and in the keratinized layers of the epidermis developed as a consequence of systemic dissemination. The spread of the infection was followed by cultures and by gross- and micropathological study of various organs of different animals during a follow-up period of 35 days. The possible relationship of organ invasion by C. albicans and skin candidosis is discussed.
D000818:Animals; D001921:Brain / Q000473:pathology; D002176:Candida albicans / Q000302:isolation & purification; D002177:Candidiasis / Q000382:microbiology / Q000473:pathology*; D004195:Disease Models, Animal; D005123:Eye / Q000473:pathology; D006168:Guinea Pigs; D007668:Kidney / Q000473:pathology; D008297:Male; D009132:Muscles / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D009928:Organ Specificity; D012867:Skin / Q000473:pathology; D013270:Stomach / Q000473:pathology; D013737:Testis / Q000473:pathology; D013997:Time Factors; D014059:Tongue / Q000473:pathology