Facilitation of neocortical kindling by depletion of forebrain noradrenaline.
The role of forebrain noradrenaline in seizures induced by electrical stimulation of the anterior neocortex (kindling) was investigated in control rats and rats pretreated with bilateral injections of 6-hydroxydopamine (6-OHDA) into the mesencephalic trajectory of the dorsal tegmental noradrenergic bundle. Extensive depletion of forebrain noradrenaline significantly facilitated the rate of development of cortico-generalized seizures.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000503:physiopathology*; D002540:Cerebral Cortex / Q000503:physiopathology*; D004558:Electric Stimulation; D006892:Hydroxydopamines / Q000494:pharmacology; D007696:Kindling, Neurologic; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D016627:Oxidopamine; D051381:Rats; D012640:Seizures / Q000503:physiopathology*
D006892:Hydroxydopamines; D016627:Oxidopamine; D009638:Norepinephrine