The effect of sulfhydryl compounds on 5-fluorouracil toxicity and distribution.
The investigations performed revealed that sulfhydryl compounds (reduced glutathione, cysteine and mesna) reduced the acute and subacute toxicity of 5-fluorouracil in mice. The above compounds changed pharmacokinetics of 5-fluorouracil increasing its accumulation in tissue compartment. The studies on 5-Fu distribution revealed its increased concentration in certain organs after administration of only certain sulfhydryl-containing compounds and only after certain doses.
D000818:Animals; D003545:Cysteine / Q000494:pharmacology; D005472:Fluorouracil / Q000378:metabolism / Q000633:toxicity*; D005978:Glutathione / Q000494:pharmacology; D007700:Kinetics; D007928:Lethal Dose 50; D008297:Male; D015080:Mesna / Q000494:pharmacology; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013438:Sulfhydryl Compounds / Q000494:pharmacology*
D013438:Sulfhydryl Compounds; D005978:Glutathione; D003545:Cysteine; D015080:Mesna; D005472:Fluorouracil