Clinical uses of lithium salts.
A comprehensive overview of the clinical aspects of lithium therapy is presented. Emphasis is placed on recent developments regarding the clinical uses of Li2CO3 in non-psychiatric conditions. The established efficacy of the drug in the treatment and prophylaxis of mania and bipolar affective disorders is noted, and the evidence supporting the use of lithium salts as a prophylactic agent in unipolar depression, aggressive behavior, schizophrenic disorders and organic brain dysfunction is discussed. The use of lithium carbonate in various disorders of movement and in certain extrapyramidal diseases is summarized, as are the results of its trials in alcoholism and drug abuse. In addition, uses of Li2CO3 in asthma, thyroid diseases, granulocytopenia, headache, bowel disease, anesthesiology, cardiology, and sleep disorders are summarized. The data suggests the potential effectiveness of Li2CO3 in a variety of clinical conditions other than those for which it is classically indicated, provided more detailed double-blind studies are performed.
D000341:Affective Disorders, Psychotic / Q000188:drug therapy; D000374:Aggression / Q000187:drug effects; D000437:Alcoholism / Q000188:drug therapy; D001249:Asthma / Q000188:drug therapy; D002986:Clinical Trials as Topic; D003027:Cluster Headache / Q000188:drug therapy; D007174:Disruptive, Impulse Control, and Conduct Disorders / Q000188:drug therapy; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D016651:Lithium Carbonate; D008575:Meniere Disease / Q000188:drug therapy; D009069:Movement Disorders / Q000188:drug therapy; D019965:Neurocognitive Disorders / Q000188:drug therapy; D009503:Neutropenia / Q000188:drug therapy; D012559:Schizophrenia / Q000188:drug therapy; D012871:Skin Diseases / Q000188:drug therapy; D012893:Sleep Wake Disorders / Q000188:drug therapy; D013959:Thyroid Diseases / Q000188:drug therapy
D016651:Lithium Carbonate; D008094:Lithium