[Buschke's scleredema and monoclonal dysglobulinemia: apropos of 3 cases].
A monoclonal gammopathy was observed in 3 adult patients with long-term and widespread scleredema (Buschke's disease). There was no evidence of multiple myeloma in any patient. The monoclonal immunoglobulin was in every case of the IgG-kappa type. Bence Jones proteinuria was noted in 1 case (kappa). Deposition of monoclonal IgG-kappa in the skin was not detected by immunofluorescence microscopy. These findings and previous reports of 5 cases suggest that diffuse scleredema may be frequently associated with paraproteinemia, but the role of monoclonal immunoglobulins in the pathogenesis of the disease remains to be clarified.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001536:Bence Jones Protein / Q000652:urine; D004562:Electrocardiography; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D007074:Immunoglobulin G / Q000032:analysis*; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D012592:Scleredema Adultorum / Q000150:complications / Q000276:immunology* / Q000473:pathology; D012867:Skin / Q000473:pathology
D007074:Immunoglobulin G; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D001536:Bence Jones Protein
Scléroedème de Buschke et dysglobulinémie monoclonale: à propos de 3 observations.