Interaction between doxorubicin and mitomycin C on mortality and myocardial contractility in guinea pig.
The present investigations were carried out in guinea pig to ascertain whether mitomycin C has a direct cardiotoxic effect or interacts with doxorubicin-induced cardiotoxicity. I.p. administration of mitomycin C did not modify the survival rate up to 30 days, whereas the combined administration of doxorubicin and mitomycin C significantly decreased the survival time in comparison to the doxorubicin-treated group. On isolated atria, mitomycin C did not cause significant inhibition of the contractile force or an enhancement of the doxorubicin-induced negative inotropic effect. These results do not support the possibility that mitomycin C potentiates the acute cardiotoxic effects produced by doxorubicin.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity*; D004317:Doxorubicin / Q000633:toxicity*; D004347:Drug Interactions; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D016685:Mitomycin; D008937:Mitomycins / Q000633:toxicity*; D009200:Myocardial Contraction / Q000187:drug effects*
D000903:Antibiotics, Antineoplastic; D008937:Mitomycins; D016685:Mitomycin; D004317:Doxorubicin