Salt-induced conversion of B-DNA to Z-DNA inhibited by aflatoxin B1.
The carcinogen aflatoxin B1 was reacted with a polymer of alternating deoxyguanine and deoxycytosine residues to determine the effect that adduct formation has on the conversion of this polymer from the right-handed B-DNA form found at low salt concentrations to the left-handed Z-DNA form found at high salt concentrations. Reaction with aflatoxin strongly inhibited the salt-induced conversion of this polymer from B-DNA to Z-DNA. This inhibition could be detected even at relatively low binding levels.
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000494:pharmacology*; D002942:Circular Dichroism; D004247:DNA / Q000378:metabolism*; D007700:Kinetics; D009690:Nucleic Acid Conformation; D009994:Osmolar Concentration; D012965:Sodium Chloride / Q000494:pharmacology
D000348:Aflatoxins; D012965:Sodium Chloride; D004247:DNA; D016604:Aflatoxin B1