The influence of chloroquine on the formation of porphyrins by yeasts.
A single two-compartment model suitable for studying the production and elimination of porphyrins from cells was prepared. Chloroquine with increasing concentrations:-- Inhibits the total production of porphyrins. Reduces intracellular concentration of porphyrins. Increases transversal permeation of porphyrins through the cellular membrane.
D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002738:Chloroquine / Q000494:pharmacology*; D008954:Models, Biological; D011166:Porphyrins / Q000096:biosynthesis*; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000378:metabolism
D011166:Porphyrins; D002738:Chloroquine