Hemophilic dogs response to Bridge anticoagulant neutralizing agent.
When Bridge anticoagulant neutralizing agent, prepared by column fractionation, was infused with factor VIII concentrate into a hemophilic dog, the apparent level of circulating factor VIII was markedly increased. Material isolated from 30 ml donor plasma raised the level of factor VIII nearly three-fold, during the first post-transfusion hour. This was achieved without shortening the period during which a hemostatically-effective level of factor VIII was maintained. The same dose also reduced the amount of factor VIII required for prompt and successful hemostasis after standardized template gingival biopsy.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D003029:Coagulants / Q000008:administration & dosage*; D004285:Dogs; D005164:Factor IX / Q000037:antagonists & inhibitors; D015949:Factor IXa; D005169:Factor VIII / Q000032:analysis*; D006467:Hemophilia A / Q000188:drug therapy*; D009930:Organic Chemicals
C039584:Bridge anticoagulant neutralizing agent; D003029:Coagulants; D009930:Organic Chemicals; D005169:Factor VIII; D005164:Factor IX; D015949:Factor IXa