[Antifactor VIII antibody in Rosai-Dorfman disease].
The case of a 72 year-old man with a sinus histiocytosis is reported. The clinical course was characterised by an hemorrhagic disorder linked to a factor VIII inhibitor. The characteristics of the antibody titer, affinity and saturability have been studied. In an attempt to stop the bleeding treatment included human and porcine factor VIII concentrates, plasmapheresis and immunosuppressive drugs. Repeated plasma exchanges did not modify the inhibitor titer for more than 24 h.
D000368:Aged; D000818:Animals; D000906:Antibodies / Q000032:analysis*; D001778:Blood Coagulation Disorders / Q000150:complications / Q000276:immunology* / Q000628:therapy; D005169:Factor VIII / Q000008:administration & dosage / Q000276:immunology*; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000276:immunology* / Q000628:therapy; D006801:Humans; D008297:Male; D010956:Plasmapheresis; D013552:Swine
D000906:Antibodies; D005169:Factor VIII
Anticorps antifacteur VIII au cours d'une maladie de Rosai-Dorfman.