[Metabolism of parenterally administered amino acids in chronic kidney failure in childhood].
Twenty children (8 months to 17 years old) with chronic renal insufficiency were infused with a 10% L-amino acid solution (1 ml/kg B.W. over 3-5 min). Amino acid blood concentrations were measured in the basal state and repeatedly after the end of infusion. The elimination constant, half-life, clearance, corrected transfer and pool size were calculated for the individual amino acids. The results were analyzed for gender specific and age-related differences. The control group consisted of 19 healthy children. (1) Almost all basal free amino acid concentrations in the chronic renal patients showed abnormalities typical for this disease. (2) Calculation of the pharmacokinetic data demonstrated differences between chronic renal patients with predominantly glomerular and those with predominantly tubular disease. (3) The half-lives and elimination constants did not differ from normal. Evaluation of age-related changes demonstrated no abnormalities for these 2 parameters in renal patients. (4) On the average, the clearance value for the group with primarily glomerular disease was 57% of normal; that of the group with predominantly tubular disease was 115% of normal. (5) Analogously, the average corrected transfer was 56% and 113% of normal; the pool size was 67% and 139% of normal. (6) No gender specific differences were found. (7) The clearance values for lysine, threonine, glycine and proline in infants and toddlers exceeded those found in older children. (8) The corrected transfer values for threonine, arginine, histidine, glycine, alanine and serine in children 8 to 31 months of age were significantly higher than those found in the rest of the children. (9) No significant age-related differences in pool size were found.
D000293:Adolescent; D000596:Amino Acids / Q000008:administration & dosage* / Q000097:blood; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D010288:Parenteral Nutrition
D000596:Amino Acids
Untersuchungen über die Verwertung parenteral zugeführter Aminosäuren bei chronischer Niereninsuffizienz im Kindesalter.