Antihepatotoxic principles of Atractylodes rhizomes.
Extracts of various samples of the crude drug prepared from Atractylodes rhizomes exhibited antihepatotoxic activity by in vitro assay methods using carbon tetrachloride- and galactosamine-induced cytotoxicity in primary cultured rat hepatocytes. The main sesquiterpenoid components were subjected to screening by these methods to reveal that atractylon, beta-eudesmol, and hinesol exerted significant liver-protective effects. Some analogs were also assayed.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology; D002478:Cells, Cultured; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology / Q000517:prevention & control*; D005688:Galactosamine; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats
D010936:Plant Extracts; D005688:Galactosamine; D009251:NADPH-Ferrihemoprotein Reductase