On the possible presence of a beta 2-microglobulin-like protein in extracts of livers from normal chickens and chickens with erythroblastosis-III. Immunological relationship to serum albumin of a small molecular weight human liver protein.
Human liver contains a small molecular weight protein (SMWP) previously shown to be biochemically homologous with a chicken liver protein in terms of its amino acid residues. This human protein, which reacts immunologically as a human serum protein, has been tested for its reactions against a battery of antisera that react specifically with many of the human serum proteins. Material prepared from four human livers gave strong reactions in double gel immunodiffusion with an antiserum against human albumin. One of the liver preparations reacted weakly with antiserum against human ferritin; this ferritin is assumed to be a contaminant. Because of the biochemical homology of human liver SMWP with chicken liver SMWP the latter would be expected to react immunologically as serum albumin.
D001355:Alpharetrovirus; D000818:Animals; D001353:Avian Leukosis / Q000378:metabolism; D002645:Chickens; D006801:Humans; D007120:Immunochemistry; D005779:Immunodiffusion; D008099:Liver / Q000032:analysis*; D008970:Molecular Weight; D012709:Serum Albumin / Q000032:analysis*; D001613:beta 2-Microglobulin / Q000032:analysis
D012709:Serum Albumin; D001613:beta 2-Microglobulin