Bupropion's prophylactic efficacy in bipolar affective illness.
Three bipolar manic-depressive patients are described who, after responding to bupropion treatment for an acute depressive relapse, were maintained on the drug alone for a 1-year period, without recurrences of mania or depression. Discontinuation of medication was followed within 8 weeks by a manic or depressive recurrence in all three cases. Data are presented to suggest that bupropion probably exerted a prophylactic effect in preventing acute affective recurrences in these cases. This drug merits investigational attention as an alternative approach to current maintenance chemotherapy of recurrent affective disorder.
D000208:Acute Disease; D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000235:genetics / Q000517:prevention & control* / Q000523:psychology; D016642:Bupropion; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D008094:Lithium / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011427:Propiophenones / Q000627:therapeutic use*; D012008:Recurrence
D000928:Antidepressive Agents; D011427:Propiophenones; D016642:Bupropion; D008094:Lithium; D007099:Imipramine