[Sensitivity of Plasmodium falciparum to chloroquine in the hyperendemic malaria savannah zone of Burkina Faso ex-Upper Volta. Use of in vivo and in vitro tests. Demonstration of a resistant strain in vitro].
Studies on the response of P. falciparum to chloroquine was conducted in schools located in the environs of Koudougou (Burkina Faso, Upper-Volta), where malaria is meso to hyperendemic, using in vivo studies and in vitro macroculture tests. Cases were obtained from school children, semi-immune asymptomatic carriers, in the 7-12 years-group.
D002050:Burkina Faso; D002648:Child; D002738:Chloroquine / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests / Q000379:methods; D010963:Plasmodium falciparum / Q000187:drug effects*
D002738:Chloroquine
Etude de la sensibilité de Plasmodium falciparum à la chloroquine dans une zone de savane du Burkina Faso Ex-Haute-Volta à paludisme hyperendémique. Utilisation des tests in vivo et in vitro. Mise en évidence d'une souche résistante in vitro.