Perspectives and future trends in cellular electrophysiology: implications for the clinician.
As a result of single fiber electrophysiologic studies, the clinical approach to the electrical behavior of the heart has improved. Three areas are examined: 1) the electrocardiographic waveform, 2) normal and abnormal cardiac rhythms, and 3) the mechanism of action of antiarrhythmic drugs. In each area, the results of single fiber studies have provided a conceptual framework for diagnostic and therapeutic decisions. These studies have also enabled investigators to test hypotheses formulated from clinical observations. It may be only a slight exaggeration to attribute many of our recent advances in each of the three areas to the development and use of the microelectrode.
D000200:Action Potentials; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000503:physiopathology; D004562:Electrocardiography; D004594:Electrophysiology; D000882:Haplorhini; D006321:Heart / Q000502:physiology*; D006329:Heart Conduction System / Q000503:physiopathology; D006801:Humans; D009203:Myocardial Infarction / Q000503:physiopathology; D009206:Myocardium / Q000166:cytology; D011188:Potassium / Q000502:physiology; D013552:Swine
D000889:Anti-Arrhythmia Agents; D011188:Potassium