[Stereospecificity of the action of alpha-aminoadipic acid on the retina: a morphological and electrophysiological study].
An intravitreal injection of the D isomer of the alpha-amino adipic acid (alpha-aa) entails the progressive disappearance of the ERG b wave as well as that of tectal evoked potentials (TEP). These physiological effects are concomitant with a specific glial cell damage in frog and chicken retinas. At low concentrations, the L isomer is more gliotoxic than the D isomer; the ERG b wave is suppressed while TEP are always recorded. At higher concentrations, the L isomer suppresses TEP and damages both glial and neuronal cells.
D015074:2-Aminoadipic Acid / Q000494:pharmacology*; D000600:Amino Acids, Dicarboxylic / Q000494:pharmacology*; D000818:Animals; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D004596:Electroretinography; D005071:Evoked Potentials / Q000187:drug effects; D011898:Ranidae; D012160:Retina / Q000166:cytology / Q000187:drug effects* / Q000502:physiology
D000600:Amino Acids, Dicarboxylic; D015074:2-Aminoadipic Acid
Stéréospécificité de l'action de l'acide alpha-aminoadipique sur la rétine: étude morphologique et électrophysiologique.