Effect of estrogens on human blood lymphocyte subpopulations in vitro.
Human blood lymphocytes were incubated for 24 hr in medium containing different physiological concentrations of 17 beta-estradiol and estrone. Both hormones caused a diminished expression of C'3 receptors on the cells, as detected by a rosette assay (EAC-rosettes). The expression of membrane receptors for sheep red blood cells (SRBC) was impaired by estrone, but not by 17 beta-estradiol.
D000328:Adult; D004958:Estradiol / Q000494:pharmacology*; D004970:Estrone / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000032:analysis / Q000145:classification / Q000187:drug effects*; D016177:Macrophage-1 Antigen; D008875:Middle Aged; D011951:Receptors, Complement / Q000032:analysis; D011971:Receptors, Immunologic / Q000032:analysis; D012397:Rosette Formation
D016177:Macrophage-1 Antigen; D011951:Receptors, Complement; D011971:Receptors, Immunologic; D004970:Estrone; D004958:Estradiol