Impaired metabolism of arachidonate in selenium deficient animals.
Arachidonate-induced respiratory distress in mice was aggravated in a selenium deficient group as compared with a selenium supplemented one. The aggravation in selenium deficient mice may be due to enhanced platelet aggregation and suppressed formation of prostacyclin (PGI2) in the arterial all.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D003094:Collagen / Q000494:pharmacology; D004032:Diet; D008297:Male; D051379:Mice; D010974:Platelet Aggregation; D051381:Rats; D011919:Rats, Inbred Strains; D012131:Respiratory Insufficiency / Q000139:chemically induced; D012643:Selenium / Q000172:deficiency*
D001095:Arachidonic Acids; D016718:Arachidonic Acid; D000244:Adenosine Diphosphate; D003094:Collagen; D012643:Selenium