Studies on the oxygen toxicity after administration of chelate-forming agents in mice.
The influence of the chelating agents CaNa2-EDTA, penicillamine, dimercaprol, unithiol, dithiocarb, aurin tricarboxylic acid, salicylic acid, and acetylsalicylic acid on the toxicity of oxygen at elevated tension was studied in mice. With the possible exception of dimercaprol, no increase in toxic effects of oxygen was observed after administering these chelate-forming agents in the doses used.
D000818:Animals; D002245:Carbon Dioxide / Q000633:toxicity; D002614:Chelating Agents / Q000008:administration & dosage*; D004112:Dimercaprol / Q000633:toxicity; D004357:Drug Synergism; D005260:Female; D006931:Hyperbaric Oxygenation; D008297:Male; D051379:Mice; D010100:Oxygen / Q000633:toxicity*; D012640:Seizures / Q000139:chemically induced*; D014202:Tremor / Q000139:chemically induced*
D002614:Chelating Agents; D004112:Dimercaprol; D002245:Carbon Dioxide; D010100:Oxygen