Adenosine deaminase and purine nucleoside phosphorylase activities in peripheral blood cells of patients with neoplastic diseases. I. Bronchogenic carcinoma.
By means of sensitive and specific radiochromatographic methods the activities of adenosine deaminase and purine nucleoside phosphorylase in peripheral blood cells of patients with bronchogenic carcinoma were estimated. It has been shown that purine nucleoside phosphorylase activity was two- to three-fold higher in lymphocytes of patients with epidermoid as well as other types of bronchogenic carcinoma in comparison with a group of healthy individuals. Adenosine deaminase activity in lymphocytes was elevated only in the group of patient with nonepidermoid carcinoma. The authors suggest that especially the estimation of purine phosphorylase activity in lymphocytes would be a useful laboratory test in the study of immune responsiveness of patients with bronchogenic carcinoma.
D000243:Adenosine Deaminase / Q000032:analysis*; D002283:Carcinoma, Bronchogenic / Q000097:blood*; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood*; D008214:Lymphocytes / Q000201:enzymology*; D009700:Nucleoside Deaminases / Q000032:analysis*; D010430:Pentosyltransferases / Q000032:analysis*; D011683:Purine-Nucleoside Phosphorylase / Q000032:analysis*
D010430:Pentosyltransferases; D011683:Purine-Nucleoside Phosphorylase; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase