The direct effects of compliance on health outcome.
Six studies that randomized patients to drugs versus placebo and also made complaint/noncompliant determinations were reviewed to document the main effects of compliance on health outcome. While the studies varied in terms of demonstrating a main effect of drugs, in five of six cases a main statistical effect of compliance was observed. Possible mechanisms for this effect are briefly noted.
D000437:Alcoholism / Q000188:drug therapy; D002746:Chlorpromazine / Q000627:therapeutic use; D006063:Chorionic Gonadotropin / Q000627:therapeutic use; D002994:Clofibrate / Q000627:therapeutic use; D003327:Coronary Disease / Q000188:drug therapy; D004221:Disulfiram / Q000627:therapeutic use; D004358:Drug Therapy / Q000523:psychology*; D006801:Humans; D009369:Neoplasms / Q000188:drug therapy; D009765:Obesity / Q000188:drug therapy; D010349:Patient Compliance; D010919:Placebos; D011897:Random Allocation; D012559:Schizophrenia / Q000188:drug therapy
D006063:Chorionic Gonadotropin; D010919:Placebos; D002994:Clofibrate; D004221:Disulfiram; D002746:Chlorpromazine