Immunogenetic differences in subpopulations of patients with IgA nephropathy (Berger's disease).
Gm and Km as well as HLA-A, HLA-B, and HLA-DR phenotype frequencies were examined in 64 well-defined IgA nephropathy patients. The patients were divided into subpopulations according to clinical symptoms, e.g. macrohematuria and chronic renal failure (CRF). In patients with CRF the frequency of the Gm1,3,17;5,13,21 phenotype tended to be increased (p = 0.016; pcorr = 0.08). The frequency of the HLA-DR phenotype with only one antigen (HLA-DR-) was increased in the whole population (p less than 0.001; pcorr less than 0.011), which appeared to be confined to the patients with macrohematuria (p less than 0.001; pcorr less than 0.01) and non-CRF (p less than 0.001; pcorr less than 0.011). Patients with the Gm1,3,17;5,13,21 phenotype developed a CRF significantly earlier (p = 0.009; pcorr = 0.045) than patients with other Gm phenotypes. These data suggest that clinically observed subpopulations of IgA nephropathy patients differ in immunogenetic background.
D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers; D005260:Female; D005787:Gene Frequency; D005922:Glomerulonephritis, IGA / Q000145:classification* / Q000235:genetics / Q000276:immunology / Q000401:mortality; D006680:HLA Antigens / Q000235:genetics*; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007129:Immunoglobulin Gm Allotypes / Q000235:genetics*; D007131:Immunoglobulin Km Allotypes / Q000235:genetics*; D007676:Kidney Failure, Chronic / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009426:Netherlands / Q000453:epidemiology; D010641:Phenotype; D015996:Survival Rate
D015415:Biomarkers; D006680:HLA Antigens; D007129:Immunoglobulin Gm Allotypes; D007131:Immunoglobulin Km Allotypes