Immunity to sarcocystosis: modification of intestinal coccidiosis, and disappearance of sarcocysts in dairy goats.
Fifty, 2-3 month old dairy goats were each vaccinated orally with 10000 sporocysts of Sarcocystis capracanis and 25 age-matched goats served as uninoculated controls. Groups of vaccinated and control goats were challenged with lethal doses of S. capracanis at 95, 113, 205, and 274 days post-vaccination. Vaccinated goats developed subclinical sarcocystosis. Twenty-three vaccinated goats and 1 control goat died of intestinal coccidiosis and bacterial pneumonia, 15-118 days after vaccination. Myositis and degenerating sarcocysts were seen in muscles of goats necropsied at 90-186 days postvaccination. Very few, or no sarcocysts were seen in goats necropsied at 272 and 332 days post-vaccination. Vaccinated goats survived a lethal challenge inoculation indicating persistent protective immunity.
D000818:Animals; D005260:Female; D006041:Goats / Q000276:immunology*; D008297:Male; D012522:Sarcocystis / Q000276:immunology* / Q000302:isolation & purification; D012523:Sarcocystosis / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D014611:Vaccination / Q000662:veterinary; D014612:Vaccines / Q000276:immunology*
D014612:Vaccines