[Double-mutation hypothesis of carcinogenesis].
Recent data on cell oncogenes, recessive mutations of certain genes which result in malignization, protective effects of polyploidy are discussed from the standpoint of mutation hypothesis of carcinogenesis. In general, these data and models confirm main conclusions of the two-step hypothesis of carcinogenesis which was put forward by V. A. Strunnikov in 1958.
D000483:Alleles; D000818:Animals; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000235:genetics; D004171:Diploidy; D005786:Gene Expression Regulation; D005808:Genes, Recessive; D006801:Humans; D008938:Mitosis; D008957:Models, Genetic; D009154:Mutation; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics; D009374:Neoplasms, Experimental / Q000209:etiology* / Q000235:genetics; D009857:Oncogenes; D011123:Polyploidy
D004273:DNA, Neoplasm
Dvumutatsionnaia gipoteza kantserogeneza.