Endomyocardial fibrosis in rats treated with N-nitrosomorpholine.
Endomyocardial fibrosis was observed after long lag periods in male Sprague-Dawley rats treated for 1-14 weeks with the carcinogen N-nitrosomorpholine. The fibrosis developed predominantly in the left ventricle. It occurred during 29-78 weeks after withdrawal of the carcinogen in 5% and 79-108 weeks after withdrawal in 20% of the experimental animals, but was never observed in controls of the same age. We suggest that endomyocardial fibrosis was induced by a direct effect of the carcinogen on the fibroblasts of the endomyocardium.
D000818:Animals; D002273:Carcinogens; D004719:Endomyocardial Fibrosis / Q000139:chemically induced* / Q000473:pathology; D006352:Heart Ventricles / Q000473:pathology; D008297:Male; D009602:Nitrosamines / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002273:Carcinogens; D009602:Nitrosamines; C002741:N-nitrosomorpholine