A comparison of flurbiprofen and paracetamol in the treatment of primary dysmenorrhoea.
Twenty-five patients suffering from primary dysmenorrhoea took part in a double-blind crossover study which demonstrated flurbiprofen (100 mg three times a day) to be significantly more effective than paracetamol (1 g three times a day) in providing pain relief on Days 1 and 2, and on the worst day of pain. Flurbiprofen also appeared to reduce the incidence of secondary symptoms of nausea and feeling faint, and menstrual blood loss. The study was also analyzed as if a parallel group study and showed flurbiprofen to be significantly more effective than paracetamol.
D000082:Acetaminophen / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D016861:Cyclooxygenase Inhibitors; D004311:Double-Blind Method; D004412:Dysmenorrhea / Q000188:drug therapy*; D005260:Female; D005480:Flurbiprofen / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D010146:Pain / Q000188:drug therapy; D011422:Propionates / Q000627:therapeutic use*
D016861:Cyclooxygenase Inhibitors; D011422:Propionates; D000082:Acetaminophen; D005480:Flurbiprofen