Optic gliomata affecting twins with neurofibromatosis.
Monozygotic twins with neurofibromatosis both showed accelerated growth in association with optic glioma. Endocrine abnormalities were similar, but only one of the two had precocious puberty. This identical presentation in twins supports the view that the site of tumour formation is determined during intra-uterine development.
D000328:Adult; D001932:Brain Neoplasms / Q000150:complications*; D002675:Child, Preschool; D003390:Cranial Nerve Neoplasms / Q000150:complications*; D004200:Diseases in Twins; D005260:Female; D005910:Glioma / Q000150:complications*; D006130:Growth Disorders / Q000209:etiology; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009456:Neurofibromatosis 1 / Q000150:complications*; D009901:Optic Nerve Diseases / Q000150:complications*
D013006:Growth Hormone