Valiolamine, a new alpha-glucosidase inhibiting aminocyclitol produced by Streptomyces hygroscopicus.
Valiolamine, a new aminocyclitol has been isolated from the fermentation broth of Streptomyces hygroscopicus subsp. limoneus and its structure has been determined to be (1(OH),2,4,5/1,3)-5-amino-1-C-(hydroxymethyl)-1,2,3,4-cyclohexanetetr ol. Valiolamine has more potent alpha-glucosidase inhibitory activity against porcine intestinal sucrase, maltase and isomaltase than valienamine, validamine and hydroxyvalidamine which were reported as building blocks of validamycins and microbial oligosaccharide alpha-glucosidase inhibitors. In addition, valienamine, validamine and hydroxyvalidamine have been isolated from the fermentation broth.
D055598:Chemical Phenomena; D002621:Chemistry; D005959:Glucosidases / Q000037:antagonists & inhibitors*; D065089:Glycoside Hydrolase Inhibitors; D007294:Inositol / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism*; D050111:Imino Sugars
D005959:Glucosidases; D065089:Glycoside Hydrolase Inhibitors; D007294:Inositol; C043270:valiolamine; D050111:Imino Sugars