The stimulation of macrophage prostaglandin E2 and thromboxane B2 secretion by Streptococcus mutans insoluble glucans.
The effect of insoluble glucan synthesized by Streptococcus mutans on [3H]arachidonate metabolites secretion from peritoneal macrophages was studied. Insoluble glucans stimulated [3H]arachidonate release and secretion of prostaglandin E2 and thromboxane B2 from macrophages. In contrast, commercial soluble glucan (dextran) did not induce [3H]arachidonate release.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D002478:Cells, Cultured; D015232:Dinoprostone; D005260:Female; D005936:Glucans / Q000494:pharmacology*; D006168:Guinea Pigs; D008264:Macrophages / Q000187:drug effects / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism*; D013295:Streptococcus mutans; D013929:Thromboxane B2 / Q000378:metabolism*; D013931:Thromboxanes / Q000378:metabolism*; D013997:Time Factors
D001095:Arachidonic Acids; D005936:Glucans; D011458:Prostaglandins E; D013931:Thromboxanes; D016718:Arachidonic Acid; D013929:Thromboxane B2; D015232:Dinoprostone