Effect of zinc on the local Shwartzman phenomenon.
Local Shwartzman reaction is substantially reduced in intensity by zinc administered locally before and after preparation of the reaction. The endotoxin-induced accumulation of PMN leukocytes is inhibited by zinc rubbed in the skin.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins; D004926:Escherichia coli; D008297:Male; D009504:Neutrophils / Q000502:physiology; D011817:Rabbits; D051381:Rats; D012790:Shwartzman Phenomenon; D015032:Zinc / Q000494:pharmacology*
D004731:Endotoxins; D015032:Zinc