[Internucleosomal fragmentation of nuclear DNA in the mucosa of the small intestine and in bone marrow cells of irradiated rats].
DNA was isolated from thymus, bone marrow and small intestine epithelium of gamma-irradiated rats and analyzed by electrophoresis in 3% polyacrylamide gel - 0.5% agarose. The internucleosomal chromatin fragmentation was observed in all tissues investigated. In the thymus and bone marrow, DNA fragmentation increased to a maximum by the 6th hour, and in the small intestine, by the 4th hour following irradiation. No low molecular weight fragments were found in the organs under study by the 16th hour after irradiation.
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects*; D004247:DNA / Q000378:metabolism / Q000528:radiation effects*; D004591:Electrophoresis, Polyacrylamide Gel; D005720:Gamma Rays; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects*; D007421:Intestine, Small / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D008297:Male; D009691:Nucleic Acid Denaturation / Q000528:radiation effects; D009707:Nucleosomes / Q000378:metabolism / Q000528:radiation effects*; D011833:Radiation Injuries, Experimental / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D014916:Whole-Body Irradiation
D009707:Nucleosomes; D004247:DNA
Mezhnukleosomnaia fragmentatsiia iadernoĭ DNK v slizistoĭ tonkogo kishechnika i kostnogo mozga obluchennykh krys.