Deswelling of the graft cornea following hypoxic oedema.
Both corneas of 12 unilateral graft patients were subjected to 9% hypoxic oedema. Following removal of the hypoxic stimulus, the grafted corneas deswelled at a significantly slower rate (P less than 0.01) than the fellow unoperated corneas. We suggest that this can be attributed to a change in the barrier properties and/or pump efficiency of the endothelium. Monitoring corneal deswelling following hypoxic oedema could form the basis of a clinical test of corneal endothelial function.
D000328:Adult; D000368:Aged; D002455:Cell Division; D003315:Cornea / Q000473:pathology / Q000503:physiopathology; D016039:Corneal Transplantation; D004487:Edema / Q000473:pathology*; D004727:Endothelium / Q000473:pathology / Q000503:physiopathology; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013997:Time Factors