[Prostaglandin E1 (misoprostol) and S-adenosylmethionine in the prevention of hemorrhagic gastritis induced by aspirin in the human. Endoscopic, histologic and histochemical study].
On 58 healthy subjects, it was evaluated in endoscopic and histopathologic form, the cytoprotective effect on the gastroduodenal mucosa, such of T.G.E 1 (misoprostol) as of SAMe, in the present of acute bleeding gastritis induced by 1300 mg aspirin in a single dose and during 2 hours. SAMe was given in progressive doses up to 500 mg, which were ingested simultaneously with aspirin, and so with Misoprostol in doses of 50 mg, showed an endoscopic score of 0 without microscopic lesion of the gastroduodenal mucosa, this was confirmed by the histopathology, where both drugs give a cytoprotection of the gastroduodenal mucosa by about 95% of total biopsies gastrointestinal mucosa. It is suggest that T.G.E.1 (misoprostol) and SAMe are choice drugs in the treatment of hemorrhagic gastritis.
D000328:Adult; D000527:Alprostadil; D001241:Aspirin / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004386:Duodenum / Q000473:pathology; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects; D005756:Gastritis / Q000139:chemically induced / Q000517:prevention & control*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011458:Prostaglandins E / Q000494:pharmacology / Q000627:therapeutic use*; D012436:S-Adenosylmethionine / Q000494:pharmacology / Q000627:therapeutic use*; D013270:Stomach / Q000473:pathology
D011458:Prostaglandins E; D012436:S-Adenosylmethionine; D000527:Alprostadil; D001241:Aspirin
La prostaglandina E 1 (misoprostol) y el SAMe en la prevención de las gastritis hemorrágicas inducida por aspirina, en el hombre. Estudio endoscópico, histológico e histoquímico.