The biosynthesis of jasmonic acid: a physiological role for plant lipoxygenase.
Linolenic acid was converted to a cyclic product, 12-oxo-phytodienoic acid, by lipoxygenase and hydroperoxide cyclase enzymes present in Vicia faba pericarp. Isotope labeling studies in which [U-14C] 12-[180] oxo-phytodienoic acid was incubated with thin sections of pericarp tissue showed that 12-oxo-phytodienoic acid is a biosynthetic precursor to jasmonic acid, a plant growth regulator which promotes senescence. Key enzymes proposed for this pathway are a reductase enzyme which reduces a double bond in the cyclopentenone ring, and beta-oxidation enzymes which remove six carbons from the carboxyl end of the molecule.
D003517:Cyclopentanes / Q000096:biosynthesis*; D008401:Gas Chromatography-Mass Spectrometry; D008042:Linolenic Acids / Q000378:metabolism; D008084:Lipoxygenase / Q000378:metabolism*; D054883:Oxylipins; D010944:Plants / Q000201:enzymology*
D003517:Cyclopentanes; D008042:Linolenic Acids; D054883:Oxylipins; C011006:jasmonic acid; D008084:Lipoxygenase