[Whole-body irradiation for bone marrow transplantation].
High dose total body irradiation is widely used in conditioning regimens to treat patients undergoing bone marrow transplantation. Radiation-related complications observed in 67 patients who received total body irradiation and their correlation with physiopathological mechanism of clinical manifestations are discussed. Interstitial pneumonitis occurred in 9 patients in our study (14%); the relationship between the incidence of interstitial pneumonitis and many factors such as irradiation treatment techniques, pre-graft chemotherapy, bone marrow malignant as well hereditary diseases, are discussed and related to a detailed literature review. Radiation techniques are different in leukemic and thalassemic patients.
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007223:Infant; D007938:Leukemia / Q000628:therapy; D008297:Male; D011658:Pulmonary Fibrosis / Q000209:etiology; D011879:Radiotherapy Dosage; D013789:Thalassemia / Q000628:therapy; D014916:Whole-Body Irradiation / Q000009:adverse effects / Q000379:methods*
D003520:Cyclophosphamide
La irradiazione corporea totale per il trapianto di midollo osseo.