[Proliferation of poorly differentiated cells in the rat liver after a single injection of the hepatocarcinogen 4-dimethylaminoazobenzine and its noncarcinogenic analog].
With the aid of autoradiography, the proliferation of non-differentiated (oval and transitional) cells in rat liver induced by a single injection of hepatocarcinogen 4-dimethylaminoazobenzene and its non-carcinogenic analogue has been studied. These cells are characterized by a high proliferative activity reaching its maximum 4 days after injection of both the agents. Later on, the proliferative activity decreased due probably to differentiation of such cells.
D000818:Animals; D001391:Azo Compounds / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects*; D008297:Male; D051381:Rats; D013997:Time Factors; D010128:p-Aminoazobenzene / Q000031:analogs & derivatives / Q000494:pharmacology*; D004124:p-Dimethylaminoazobenzene / Q000494:pharmacology*
D001391:Azo Compounds; C007368:C.I. Solvent Yellow 56; D010128:p-Aminoazobenzene; D004124:p-Dimethylaminoazobenzene
Proliferatsiia nizkodifferentsirovannykh kletok v pecheni krys posle odnokratnoĭ in''ektsii gepatokantserogena 4-dimetilaminoazobenzola i ego nekantserogennogo analoga.