Synergistic anti-tumor effect of mini-cells prepared from Salmonella typhimurium with mitomycin C in EL4-bearing mice.
A statistically significant increase in survival time was observed in EL4-bearing mice after a mini-cell inoculation. However, no case of survival for over 30 days was observed after an EL4 graft in mice treated with mini-cells alone. Fifty percent of the mice survived for 40 days after an EL4 transplantation when the mice were treated with both an IV injection of mini-cells and an SC injection of mitomycin C. The mini-cell injection restored the macrophage chemotaxis activity in EL4-bearing mice but did not restore the lymphocyte activities.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D002460:Cell Line; D007167:Immunotherapy; D007942:Leukemia, Experimental / Q000188:drug therapy / Q000276:immunology / Q000628:therapy*; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D016685:Mitomycin; D008937:Mitomycins / Q000627:therapeutic use*; D012486:Salmonella typhimurium / Q000276:immunology*
D000903:Antibiotics, Antineoplastic; D008937:Mitomycins; D016685:Mitomycin