The effect of tranexamic acid on growth and spread of an experimental tumor model.
In the spontaneously metastasizing murine P815 mastocytoma studied, exposure of the cell cultures to Tranexamic acid increased plasminogen activator activity (PAA) in the cytosol and in the primary solid tumors. These increased PAA levels were associated with an increased rate of metastasis to the liver.
D000818:Animals; D002478:Cells, Cultured; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D003600:Cytosol / Q000378:metabolism; D012515:Mast-Cell Sarcoma / Q000473:pathology; D051379:Mice; D008811:Mice, Inbred DBA; D009362:Neoplasm Metastasis; D010960:Plasminogen Activators / Q000494:pharmacology; D012513:Sarcoma, Experimental / Q000473:pathology*; D014148:Tranexamic Acid / Q000494:pharmacology*
D003509:Cyclohexanecarboxylic Acids; D014148:Tranexamic Acid; D010960:Plasminogen Activators