Neurologic complications induced by gold treatment.
Two patients developed a Guillain-Barre-like syndrome and a third suffered neuropathy and myokymia during therapy with sodium aurothiomalate. The cumulative dose at the time of development of neuropathy was different in all 3 cases. Evidence for gold toxicity was suggested by clinical, electromyographic, and histologic findings, as well as the disappearance of symptoms and signs on cessation of gold injections.
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001706:Biopsy; D004576:Electromyography; D004594:Electrophysiology; D006052:Gold Sodium Thiomalate / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009132:Muscles / Q000502:physiology; D009422:Nervous System Diseases / Q000139:chemically induced*; D011129:Polyradiculoneuropathy / Q000473:pathology; D013497:Sural Nerve / Q000473:pathology
D006052:Gold Sodium Thiomalate