Klebsiella plasmid K21 is not involved in the aetiology of ankylosing spondylitis.
The possibility that a plasmid carried by Klebsiella pneumoniae plays a role in the pathogenesis of ankylosing spondylitis was explored. K. pneumoniae K21 contains a congruent to 25-kb plasmid, but this plasmid is not present in lymphocyte DNAs of ankylosing spondylitis HLA-B27 patients, as demonstrated by molecular hybridization experiments.
D015139:Blotting, Southern; D003429:Cross Reactions; D004247:DNA / Q000032:analysis; D004198:Disease Susceptibility; D005260:Female; D005798:Genes, Bacterial; D015796:HLA-B27 Antigen / Q000235:genetics / Q000276:immunology; D006801:Humans; D007711:Klebsiella pneumoniae / Q000235:genetics* / Q000276:immunology; D008214:Lymphocytes / Q000032:analysis; D008297:Male; D010375:Pedigree; D010957:Plasmids; D013167:Spondylitis, Ankylosing / Q000235:genetics / Q000276:immunology* / Q000382:microbiology
D015796:HLA-B27 Antigen; D004247:DNA