Dietary trilinoelaidate: effects on the in vitro biosynthesis of different prostaglandins in brain, lung and stomach fundus of rats.
The effects of dietary trilinoelaidate on the biosynthesis of different prostaglandins (PG's) from [1-14C]-arachidonic acid by brain, lung, and stomach fundus homogenates of rats were determined. Rats were fed diets containing hydrogenated tallow (essential fatty acid deficient), trilinoelaidin at 0 (control), 10 and 50 weight percent of the total dietary fat and sacrificed at the end of eleven weeks. Brain, lung and stomach fundus of rats receiving trilinoelaidin at a level of 50 weight percent of the total dietary fat and the essential fatty acids deficient diet showed increased activity for the in vitro conversion of exogenous arachidonic acid to PG's compared to controls.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D005228:Fatty Acids, Essential / Q000172:deficiency; D005748:Gastric Fundus / Q000187:drug effects / Q000378:metabolism*; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000494:pharmacology*
D001095:Arachidonic Acids; D004041:Dietary Fats; D005228:Fatty Acids, Essential; D011453:Prostaglandins; D014280:Triglycerides; D016718:Arachidonic Acid; D011451:Prostaglandin-Endoperoxide Synthases; C009564:trilinolein