Influence of non-H-2 genes on the in vivo response to penicillin-treated autologous platelets.
Mice of different inbred strains were injected intravenously on day 0 and day 6 with autologous platelets incubated in a penicillin solution. After the second injection mice of most strains died immediately with anaphylactic symptoms. Both passive transfer experiments and indirect immunofluorescence studies suggest that a serum factor (probably IgM) is involved in this phenomenon. Only mice with a C3H background were unable to respond to autologous penicillin-treated platelets, although C3H platelets did induce a lethal response in B10.A mice. Experiments in which B10.A mice were primed with autologous penicillin-treated platelets and rechallenged with allogeneic penicillin-treated platelets, showed that the response is directed against a polymorphic non-H-2 antigen in combination with penicillin.
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology; D001792:Blood Platelets / Q000187:drug effects / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006183:H-2 Antigens / Q000235:genetics*; D007116:Immunization, Passive; D008775:Methylprednisolone / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology*; D010406:Penicillins / Q000276:immunology / Q000494:pharmacology*; D011398:Promethazine / Q000494:pharmacology
D000954:Antigens, Surface; D006183:H-2 Antigens; D010406:Penicillins; D011398:Promethazine; D008775:Methylprednisolone