A nonpolymorphic class I gene in the murine major histocompatibility complex.
DNA sequence analysis of a class I gene (Q10), which maps to the Qa2,3 locus in the C57BL/10 (H-2b haplotype) mouse, reveals that it is almost identical to a cDNA clone (pH16) isolated from a SWR/J (H-2q haplotype) mouse liver cDNA library. Exon 5, in particular, has an unusual structure such that a polypeptide product is unlikely to be anchored in the cell membrane. Our findings suggest that the two sequences are derived from allelic class I genes, which are nonpolymorphic, in contrast to H-2K allelic sequences from the same mice, and they may encode liver-specific polypeptides of unknown function. Our previous studies indicate that the Q10 gene is a potential donor gene for the generation of mutations at the H-2K locus by inter-gene transfer of genetic information. Thus the lack of polymorphism in class I genes at the Q10 locus implies either that they are not recipients for such exchanges or that selective pressure prevents the accumulation of mutations in genes at this locus.
D000483:Alleles; D000818:Animals; D000954:Antigens, Surface / Q000235:genetics*; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics*; D015395:Histocompatibility Antigens Class I; D051379:Mice; D008810:Mice, Inbred C57BL; D009154:Mutation; D011110:Polymorphism, Genetic
D000954:Antigens, Surface; D006183:H-2 Antigens; D015395:Histocompatibility Antigens Class I; C032907:Q surface antigens; D004247:DNA