[Cisplatin, vindesine and VP 16-213 in the treatment of inoperable non-small cell bronchial carcinoma. A clinical phase II study].
In the treatment of non-small-cell lung cancer a drug-combination of cis-platinum, vindesine and VP-16 seemed logical because the drugs were non cross-resistant and there would be an additive effectiveness with acceptable toxicity. That was the basis for a phase-II trial started in July 1981 in which 60 patients with untreated non-small-cell lung cancer were entered until November 1982. There were 51 male and 9 female evaluable. The performance status of all patients was over 70%. Over 65% had extensive disease. The most frequent histology was squamous cell carcinoma that we found in 45% of our patients with bronchial carcinomas. Only 14 patients had large cell carcinomas and only 8 patients adenocarcinomas. 40% was the objective remission rate (5% complete remissions and 35% partial remissions). 9 patients (=15%) had a minor response; in 18 patients (=30%) there was no change, 9 patients showed progressive disease. The median survival time of responders is presently 14.9 months, which is significantly higher than the 9.1 months of non-responders. The toxicity of the triple-drug-combination was tolerable. The greatest problem was gastrointestinal toxicity with nausea and vomiting. The hematological toxicity was not as severe as expected. The renal toxicity was not a problem. We did not see drug related deaths.
D000230:Adenocarcinoma / Q000188:drug therapy; D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use* / Q000633:toxicity; D002277:Carcinoma / Q000188:drug therapy; D002283:Carcinoma, Bronchogenic / Q000188:drug therapy / Q000401:mortality; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage; D002986:Clinical Trials as Topic; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives; D014751:Vindesine
D000970:Antineoplastic Agents; D014747:Vinblastine; D005047:Etoposide; D002945:Cisplatin; D014751:Vindesine
Cisplatin, Vindesin und VP 16-213 in der Behandlung des inoperablen nicht-kleinzelligen Bronchialkarzinoms. Eine klinische Phase-II-Studie.