Growth and endocrine function after treatment for medulloblastoma.
Children with medulloblastoma in Bristol are treated surgically and with craniospinal irradiation, and in some cases chemotherapy. Thirteen medium or long term survivors were investigated to determine their growth and endocrine function. Their rate of growth was considerably reduced through the first year of their illness and after spinal irradiation spinal growth was poor. Nine children developed growth hormone deficiency. They were clinically euthyroid but 7 had raised basal thyroid stimulating hormone values. Gonadal function was abnormal in all but the youngest child. The rate of survival is increasing in children with medulloblastoma but this is associated with appreciable endocrine abnormalities. Some of these problems are present shortly after treatment ends but others may develop later and long term surveillance is therefore essential.
D000293:Adolescent; D001827:Body Height / Q000528:radiation effects; D002528:Cerebellar Neoplasms / Q000503:physiopathology / Q000532:radiotherapy / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004702:Endocrine Glands / Q000503:physiopathology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005500:Follow-Up Studies; D006128:Growth / Q000528:radiation effects; D013006:Growth Hormone / Q000172:deficiency; D006801:Humans; D008297:Male; D008527:Medulloblastoma / Q000503:physiopathology / Q000532:radiotherapy / Q000628:therapy*; D011627:Puberty / Q000528:radiation effects
D005640:Follicle Stimulating Hormone; D013006:Growth Hormone