Chromosomal aberrations, sister chromatid exchange (SCEs) and micronuclei induction with three platinum compounds (cis-DDP, CHIP, CBDCA) in V79 cells in vitro.
Three platinum compounds (cis-DDP, CHIP, CBDCA) were tested or induction of chromosome aberrations and micronuclei as well as for SCEs in V79 cells in vitro. There was a clear relationship between the degree of inhibitory activity of the tested drugs and the increase of studied markers of cytogenetic damage. Statistical significance was proved in increase of SCEs values in cis-DDP and CHIP-treated cells when compared with untreated controls.
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D016190:Carboplatin; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002467:Cell Nucleus / Q000187:drug effects* / Q000473:pathology; D002869:Chromosome Aberrations; D002945:Cisplatin / Q000633:toxicity*; D006224:Cricetinae; D003412:Cricetulus; D008168:Lung; D009944:Organoplatinum Compounds / Q000633:toxicity*; D012854:Sister Chromatid Exchange
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C023359:iproplatin; D016190:Carboplatin; D002945:Cisplatin