[Release in secondary mixed leukocyte cultures of a factor inducing citrulline production by bone marrow cells].
Citrulline production is demonstrated in murine bone marrow cell cultures incubated with dialyzed secondary MLC supernatant. This synthesis, proceeding from arginine, is induced by a soluble protein factor released during secondary MLC, unstable to heat, with a molecular weight of approximately 150,000 daltons.
D000818:Animals; D001120:Arginine / Q000378:metabolism; D001853:Bone Marrow / Q000276:immunology* / Q000378:metabolism; D002478:Cells, Cultured; D002956:Citrulline / Q000096:biosynthesis*; D005260:Female; D007962:Leukocytes / Q000276:immunology*; D008222:Lymphokines / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D012995:Solubility
D008222:Lymphokines; D002956:Citrulline; D001120:Arginine
Libération, au cours des cultures leucocytaires mixtes secondaires, d'un facteur induisant une production de citrulline par les cellules de moelle osseuse.