Relationship between plasma pyridoxal-5'-phosphate concentration and the apoenzyme content of serum aminotransferases in patients with a renal allograft.
In 76 patients with a renal allograft the plasma concentration of pyridoxal-5'-phosphate, the activity concentrations of aspartate aminotransferase and alanine aminotransferase and the percentage stimulation of both enzymes have been investigated. Generally, the concentration of the coenzyme was decreased in the patient group compared to normal individuals. The percentage increase of aspartate aminotransferase is the same for the patients as for the normal group. However, the stimulation of alanine aminotransferase is greatly increased for the patient group except for those patients who received cyclosporine A instead of azathioprine. The highly significant inverse correlation between the plasma pyridoxal-5'-phosphate concentration and the percentage stimulation of the enzymatic activity of aspartate aminotransferase and alanine aminotransferase observed before for a normal group, is not present in our patient group. The percentage increase is independent on the activity concentration of the enzymes. It is concluded that the high stimulation of alanine aminotransferase depends on the administration of azathioprine.
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D001051:Apoenzymes / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood*; D002384:Catalysis; D003524:Cyclosporins / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011732:Pyridoxal Phosphate / Q000097:blood* / Q000494:pharmacology
D001051:Apoenzymes; D003524:Cyclosporins; D006514:Hepatitis B Surface Antigens; D011732:Pyridoxal Phosphate; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase