Insulin binding to erythrocytes in children with type I diabetes mellitus before, and after insulin treatment.
125I-insulin binding to erythrocytes was studied in 24 children with type I diabetes mellitus before institution of insulin therapy, and in 10 normals. Mean specific 125I-insulin binding in the diabetics was significantly lower than in the controls (10.2 +/- 0.4% (SEM), as against 11.6 +/- 0.5%, P less than 0.05). In 8 diabetics the study was repeated after 3-6 weeks of therapy, at which time the insulin binding had increased to normal (12.1%, range 10.7-13.6). No correlation was found between insulin binding and blood glucose, plasma insulin or plasma beta-hydroxybutyrate. We conclude that insulin binding to the receptors is altered in the early phase of type I diabetes.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000627:therapeutic use; D007700:Kinetics; D008297:Male
D007328:Insulin