[Protective properties of plasma from burned and irradiated rats in relation to the in vivo lethal effects of endotoxins].
The intraperitoneal injection of Salmonella typhimurium and Escherichia coli endotoxins into previously irradiated rats killed 80% of the animals within 24 hours. After the combined injection of these endotoxins with the heterologous plasma of intact rats mortality rate decreased to 12% and 19%, respectively. A deep burn of the skin, acute radiation sickness and combined radiation and thermal lesion did not abolish this phenomenon of humoral detoxication; at different periods after the action of heat, radiation or both the plasma of the test rats exerted its protective effect practically to the same extent as in the controls.
D000208:Acute Disease; D000818:Animals; D002056:Burns / Q000276:immunology*; D004731:Endotoxins / Q000633:toxicity*; D004926:Escherichia coli; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010949:Plasma / Q000276:immunology*; D011833:Radiation Injuries, Experimental / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium; D013997:Time Factors
D004731:Endotoxins
Protektivnye svoĭstva plazmy obozhzhennykh i obluchennykh krys v otnoshenii letal'nykh éffektov éndotoksinov in vivo.