Synergistic lethality in experimental infections with Escherichia coli and Bacteroides fragilis.
Using an animal model, a synergism in lethality of infections with Escherichia coli and Bacteroides fragilis is described. This synergism was dependent on certain dosage combinations of the infectious agents. It was demonstrated that animal-passaged, laboratory-passaged, and heat-killed B. fragilis alike were capable of producing this synergism. However, animal-passaged B. fragilis showed superior recovery rates from animal organs.
D000818:Animals; D001442:Bacteroides Infections / Q000150:complications / Q000382:microbiology* / Q000401:mortality; D001441:Bacteroides fragilis / Q000254:growth & development; D004195:Disease Models, Animal; D004926:Escherichia coli / Q000254:growth & development; D004927:Escherichia coli Infections / Q000150:complications / Q000382:microbiology* / Q000401:mortality; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D009928:Organ Specificity