[Experimental induction of teratoma in rats].
To induce an experimental teratoma, fetuses of Wistar strain rats were removed from the uterus, and the visceral yolk sac was left hanging through the fetectomy incision. After several weeks of this treatment, a tumor developed in these animals with or without both side oophorectomy. Despite the fact that the visceral yolk sac is composed of endoderm and mesoderm, the tissues in the resulting tumor obtained from the ectopically implanted yolk sac showed derivatives from all three germ layers, including skin, bone, gut and nervous tissues. Changes in hormonal environment induced by oophorectomy did not affect the process of experimental tumor induction. When 7,12-dimethylbenz-(a)-anthracene (DMBA) was directly applied to the yolk sac at the fetectomy, a neoplasm mainly consisted of yolk sac elements was investigated after two to four months of the treatment. From the results of this experiment, it was seemed that an embryonic and extraembryonic teratomatous tumor might have been derived from the visceral yolk sac.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D005260:Female; D008026:Ligation; D010051:Ovarian Neoplasms / Q000209:etiology* / Q000473:pathology; D051381:Rats; D013724:Teratoma / Q000209:etiology* / Q000473:pathology; D015017:Yolk Sac / Q000601:surgery
D015127:9,10-Dimethyl-1,2-benzanthracene