Combined mutagenic action of chemicals and radiation in diploid yeast.
The interaction between the mutagenic action of chemicals and radiation was studied by using a diploid yeast strain Saccharomyces cerevisiae BZ 34 with mitotic gene conversion as the end-point. The cells were treated with EMS, MMS or 4-NQO alone or in combination with gamma-radiation. The 2 alkylating agents EMS and MMS produced an additive mutagenic response, whereas 4-NQO exhibited an antagonistic effect in the combined treatment with gamma-radiation.
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D005020:Ethyl Methanesulfonate / Q000494:pharmacology*; D005720:Gamma Rays; D005785:Gene Conversion / Q000187:drug effects / Q000528:radiation effects; D008741:Methyl Methanesulfonate / Q000494:pharmacology*; D009154:Mutation; D011839:Radiation, Ionizing; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects; D013223:Statistics as Topic
D015112:4-Nitroquinoline-1-oxide; D005020:Ethyl Methanesulfonate; D008741:Methyl Methanesulfonate