Anti-albumin antibodies in normal rabbit sera.
Antibodies reacting with homologous glutaraldehyde (GA)-modified albumin were demonstrated in normal rabbit sera (NRS) by passive hemagglutination and direct binding assay. The ability of rabbit anti-albumin antibodies (AAA) to react with homologous GA-modified albumin was found to increase with the degree of albumin polymerization. AAA did not react with GA-treated monomeric albumin. It was proved that rabbit AAA are not species-specific since they react also with heterologous GA-polymerized albumin. The possible role of AAA in the catabolism of in vivo aged albumin molecules, antigenically similar with GA-induced albumin polymers, is discussed.
D000818:Animals; D001323:Autoantibodies / Q000032:analysis / Q000502:physiology*; D001666:Binding Sites, Antibody; D001667:Binding, Competitive; D002417:Cattle; D004285:Dogs; D005976:Glutaral / Q000494:pharmacology; D006386:Hemagglutination Tests; D006801:Humans; D046911:Macromolecular Substances; D051379:Mice; D011817:Rabbits; D012709:Serum Albumin / Q000276:immunology*; D012756:Sheep
D001323:Autoantibodies; D046911:Macromolecular Substances; D012709:Serum Albumin; D005976:Glutaral