The transport of oxygen, glucose, carbon dioxide and lactic acid in the human brain: mathematical models.
Mathematical models of the transport of oxygen, glucose, carbon dioxide and lactic acid in the human brain have been developed and solved for both steady-state and dynamic cases which include normal conditions, arterial and venous hypoxia, reduced flow and hematocrit, hypocapnia, reduced glucose and transient arterial upsets. Results indicate that local concentration deficits of oxygen and/or glucose and excesses of lactic acid can exist within the system described by the models and therefore possibly could exist in the tissues of the human brain under similar conditions.
D001693:Biological Transport, Active; D001921:Brain / Q000378:metabolism*; D002245:Carbon Dioxide / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007773:Lactates / Q000378:metabolism*; D019344:Lactic Acid; D008954:Models, Biological; D010101:Oxygen Consumption
D007773:Lactates; D002245:Carbon Dioxide; D019344:Lactic Acid; D005947:Glucose