[Immunologic changes in chronic pancreatitis].
In 35 patients with chronic pancreatitis, C3, C4, s-immunoglobulins, circulating immunocomplexes and T-lymphocytes were assessed in order to verify whether an immunological role may be postulated in the pathogenesis and/or in the maintenance of the disease. A significant increase of serum IgM together with normal values of C3 and C4 and without circulating immunocomplexes was found. A significant decrease in the total number of lymphocytes as well as in the number and percentage of T-lymphocytes was also documented. These results suggest a possible involvement of immunological (humoral and cellular) processes in maintaining the chronic pancreatic damage.
D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis; D002908:Chronic Disease; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D007136:Immunoglobulins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology
D000936:Antigen-Antibody Complex; D003176:Complement C3; D003181:Complement C4; D007136:Immunoglobulins
Alterazioni immunologiche nella pancreatite cronica.