Equine adenovirus 1 isolated from cauda equina neuritis.
Equine adenovirus 1 was recovered after four to six passages from two out of three cases of cauda equina neuritis (CEN) using kidney monolayers. Similar treatment of lumbo-sacral spinal cord from six normal horses did not yield adenovirus. All three cases of CEN had antibodies to the neuritogenic myelin protein P2 while immunofluorescence demonstrated that autologous IgG bound to the myelin of affected nerves. Adenovirus was not detected in neural tissue by immunofluorescence.
D000256:Adenoviridae / Q000302:isolation & purification*; D000818:Animals; D002420:Cauda Equina; D046508:Culture Techniques; D003588:Cytopathogenic Effect, Viral; D005455:Fluorescent Antibody Technique; D006734:Horse Diseases / Q000382:microbiology*; D006736:Horses; D007668:Kidney / Q000196:embryology; D009443:Neuritis / Q000382:microbiology / Q000662:veterinary*; D014776:Virus Cultivation