Metabolic and pharmacological studies with N-methyl-N'-methyl-2'-allyl-2-benzoyl-4-chloro-glycinanilide (F 1797).
Three metabolites (F 1756, diazepam and N-desmethyl-diazepam) of N-methyl-N'-methyl-2'-allyl-2-benzoyl-4-chloro-glycinanilide (F 1797), a new potential anxiolytic agent, are formed by N-desmethylation or cyclisation in the rat. They were compared with F 1797 for their antileptazol activity in order to assess their contribution to the effect of the parent compound. F 1756 had little effect in this test. However, diazepam and N-desmethyl-diazepam formed after F 1797 certainly contributed to its antileptazol effect.
D000813:Anilides / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants; D001923:Brain Chemistry / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology; D008297:Male; D003708:Nordazepam / Q000494:pharmacology; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains
D000813:Anilides; D000927:Anticonvulsants; D003708:Nordazepam; C039102:N-methyl-N'-methyl-2'-allyl-2-benzoyl-4-chloroglycinanilide; D003975:Diazepam; D010433:Pentylenetetrazole