Effects of heparin and a semi-synthetic heparin analogue on platelet aggregation, lipoprotein lipase and other laboratory tests in surgical patients.
Platelet aggregation, lipoprotein lipase activity, coagulation parameters and routine blood chemistry were measured in a randomised study of 21 surgical patients before, immediately after and 3 months after operation. Sodium heparin 5000 IU was given subcutaneously to 11 patients every 12 hours for 7 days, the first injection 2 hours preoperatively; 10 patients received a semi-synthetic heparin analogue (SSHA 75 mg) in the same manner. The groups were sex and age matched. No conclusive changes were found in platelet aggregation. The increase in lipoprotein lipase activity in SSHA patients 2 hours after injection was significantly greater than in heparin patients. Neither of the two drugs induced significant changes in coagulation parameters or routine blood chemistry. The results indicate a difference in the effect on lipoprotein lipase release between heparin and SSHA at the used dosage schedules.
D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D001780:Blood Coagulation Tests; D002807:Chondroitin / Q000031:analogs & derivatives*; D002809:Chondroitin Sulfates / Q000627:therapeutic use*; D005260:Female; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D008071:Lipoprotein Lipase / Q000097:blood*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D011183:Postoperative Complications / Q000097:blood / Q000517:prevention & control; D013924:Thrombophlebitis / Q000201:enzymology / Q000517:prevention & control*
D000925:Anticoagulants; C026210:SSHA; D006493:Heparin; D002807:Chondroitin; D002809:Chondroitin Sulfates; D008071:Lipoprotein Lipase