Activation of xanthine dehydrogenase during the prenatal period through L-thyroxine, thiourea and cycloheximide.
Xanthine dehydrogenase activity in the liver of embryonic chicks has been shown to be inducible by L-thyroxine, thiourea, and cycloheximide. Results reported here indicate different mechanisms underlying the activation through L-thyroxine on the one hand, and through thiourea and cycloheximide on the other. Using hepatocyte suspension and homogenized liver, it has been shown that prenatal activation of xanthine dehydrogenase results in increased rate of uric acid formation from nucleic acids and purine derivatives, but not from amino acids.
D000818:Animals; D002642:Chick Embryo; D003513:Cycloheximide / Q000494:pharmacology*; D004789:Enzyme Activation / Q000187:drug effects; D007658:Ketone Oxidoreductases / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D013890:Thiourea / Q000494:pharmacology*; D013974:Thyroxine / Q000494:pharmacology*; D013997:Time Factors; D014527:Uric Acid / Q000096:biosynthesis; D014968:Xanthine Dehydrogenase / Q000378:metabolism*
D014527:Uric Acid; D003513:Cycloheximide; D014968:Xanthine Dehydrogenase; D007658:Ketone Oxidoreductases; D013890:Thiourea; D013974:Thyroxine