Lack of donor-specific tolerance in mice with established anti-Ia-treated islet allografts.
Pancreatic islet allografts pretreated in vitro with monoclonal Ia antibody and transplanted beneath the renal capsule result in normoglycemia beyond 100 days in streptozotocin-induced diabetic recipient mice that differ only at H-2 K, H-2 K + I, or H-2 K + I + D from the donors. Mice with established islet allografts are not tolerant of donor-specific skin or islet antigens, but rather reject donor skin grafts in an accelerated fashion. Established anti-Ia antibody pretreated islet allografts continue to express target antigens and remain susceptible to rejection after challenge with donor skin grafts.
D000818:Animals; D005260:Female; D006084:Graft Rejection; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D007108:Immune Tolerance; D016381:Islets of Langerhans Transplantation; D008297:Male; D051379:Mice; D016038:Skin Transplantation; D014184:Transplantation, Homologous
D000949:Histocompatibility Antigens Class II