Resistance and susceptibility to infection in inbred murine strains. II. Variations in the effect of treatment with thymosin fraction 5 on the release of lymphokines in vivo.
Of nine inbred murine strains sensitized intravenously with killed lyophilized Candida albicans and challenged 3 weeks later with a C. albicans filtrate, four strains were low responders and five were high responders in the in vivo release of migration inhibitory factor (MIF) and gamma interferon (IFN-gamma). An identical distribution of high- and low-responder strains occurred in response to sensitization with Mycobacterium bovis BCG and subsequent challenge with old tuberculin. Treatment of the murine strains with thymosin fraction 5 prior to sensitization and challenge had different effects: (a) the high-responder strains had a decrease in their release in vivo of the two lymphokines; (b) three of five of the low-responder strains had a striking increase in the in vivo release of MIF and IFN-gamma; and (c) one low-responder strain did not have its response altered. A parallelism existed between the capacity of a murine strain to release the two lymphokines in vivo on stimulation with C. albicans antigens and the capacity of that strain to resist intravenous infection with living C. albicans.
D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage; D000946:Antigens, Fungal / Q000008:administration & dosage; D002177:Candidiasis / Q000276:immunology; D004198:Disease Susceptibility; D005260:Female; D007113:Immunity, Innate / Q000187:drug effects; D007371:Interferon-gamma / Q000096:biosynthesis*; D008263:Macrophage Migration-Inhibitory Factors / Q000096:biosynthesis*; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D013947:Thymosin / Q000031:analogs & derivatives / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*; D014376:Tuberculosis / Q000276:immunology
D000942:Antigens, Bacterial; D000946:Antigens, Fungal; D008263:Macrophage Migration-Inhibitory Factors; D013951:Thymus Hormones; C033782:thymosin fraction 5; D013947:Thymosin; D007371:Interferon-gamma