Antipsoriatic drugs as inhibitors of soybean lipoxygenase. A possible mode of action.
Eight known antipsoriatic drugs of diverse structures were tested on the basis of their structural similarity with arachidonic acid and known inhibitors of lipoxygenase. A correlation was observed between their antipsoriatic activity and lipoxygenase inhibition suggesting that a common underlying mechanism of action might be involved.
D000875:Anthralin / Q000494:pharmacology; D001091:Arachidonate Lipoxygenases; D005050:Etretinate / Q000494:pharmacology; D016859:Lipoxygenase Inhibitors; D009173:Mycophenolic Acid / Q000494:pharmacology; D011565:Psoriasis / Q000188:drug therapy*; D012118:Resorcinols / Q000494:pharmacology; D012459:Salicylates / Q000494:pharmacology; D013025:Glycine max / Q000201:enzymology; D014212:Tretinoin / Q000494:pharmacology
D016859:Lipoxygenase Inhibitors; D012118:Resorcinols; D012459:Salicylates; D014212:Tretinoin; D005050:Etretinate; D001091:Arachidonate Lipoxygenases; D009173:Mycophenolic Acid; D000875:Anthralin