[Inconvenience of planned prophylaxis of transfusion-induced alloimmunization to red cells in chronic renal insufficiency].
Records from 506 hemodialysis multitransfused patients were reviewed to evaluate the incidence of transfusion induced red cell allo-immunization. Out of 405 patients having received a total of 6 608 red cell transfusions compatible for A, B and D antigens, only 7 patients (1.72%) developed allo-antibodies which may be attributed to such transfusions. Elaborate red cell phenotyping in un-immunized recipients and selection of blood units compatible for other antigens than A, B and D in an effort to prevent red cell allo-immunization to other blood group antigens in such potentially multitransfused patients does not accordingly appear to be justified and cost-effective.
D000017:ABO Blood-Group System / Q000276:immunology; D000293:Adolescent; D000328:Adult; D000368:Aged; D001787:Blood Group Incompatibility / Q000209:etiology / Q000628:therapy*; D001788:Blood Grouping and Crossmatching; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000096:biosynthesis; D007676:Kidney Failure, Chronic / Q000150:complications / Q000191:economics / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012204:Rh-Hr Blood-Group System / Q000276:immunology; D012306:Risk; D013997:Time Factors; D065227:Transfusion Reaction
D000017:ABO Blood-Group System; D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System
Inopportunité de la prophylaxie élaborée de l'allo-immunisation transfusionnelle contre les globules rouges dans l'insuffisance rénale chronique.