Influence of long-term plasmapheresis on blood coagulation.
The influence of serial, double plasmapheresis on blood coagulation was evaluated in two groups of plasma donors that had undergone from 3 to 306 plasmapheresis sessions. Averages of 375 and 660 ml of plasma, respectively, were harvested weekly from the donors. No statistically significant changes were observed in platelet count, activities of factor V and factor VIII, fibrinogen, plasminogen, alpha 2-macroglobulin, antithrombin III and prothrombin time, irrespectively of the frequency and the number of the plasmapheresis sessions. The concentration of alpha 1-antitrypsin was already increased after seven plasmapheresis sessions in both groups of donors. The kaolin-cephalin clotting time was progressively shortened with the increasing volume of harvested plasma (p less than 0.05) and the thrombin time was prolonged (p less than 0.05).
D000328:Adult; D001778:Blood Coagulation Disorders / Q000175:diagnosis / Q000209:etiology*; D001782:Blood Donors; D006801:Humans; D008134:Long-Term Care; D008297:Male; D010314:Partial Thromboplastin Time; D010956:Plasmapheresis / Q000009:adverse effects*; D011517:Prothrombin Time; D013918:Thrombin Time