Preputial tumors induced by intragastric intubations of 7,12-dimethylbenz(a)anthracene in gonadectomized female and male rats.
A series of administrations of 7,12-dimethylbenz(a)anthracene given at biweekly intervals by gastric intubation to gonadectomized rats of the Sprague-Dawley strain elicited a considerable number of preputial tumors. The tumors commonly consisted of solid and cystic parts with a wide variety of histologic features and were classified as adenomas, carcinomas, and malignant mixed tumors.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000236:Adenoma / Q000139:chemically induced / Q000473:pathology; D000818:Animals; D001551:Benz(a)Anthracenes / Q000633:toxicity*; D002277:Carcinoma / Q000139:chemically induced / Q000473:pathology; D002369:Castration; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012627:Sebaceous Glands
D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene