Molecular mechanisms of action of auranofin and other gold complexes as related to their biologic activities.
The molecular mechanisms of action of gold complexes in the treatment of rheumatoid arthritis are partially known, as are the mechanisms of action and potential utility of gold complexes in the treatment of neoplastic disease. In this paper, data relative to the mechanism of cytotoxicity and structure activity relationships are presented. Concepts of future research are also discussed.
D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects; D000970:Antineoplastic Agents / Q000494:pharmacology; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001310:Auranofin; D006051:Aurothioglucose / Q000031:analogs & derivatives* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004278:DNA, Superhelical / Q000032:analysis; D006046:Gold / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D008545:Melanoma; D008668:Metallothionein / Q000378:metabolism; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D004278:DNA, Superhelical; D006051:Aurothioglucose; D001310:Auranofin; D006046:Gold; D008668:Metallothionein