Formaldehyde mutagenesis in Drosophila. Molecular analysis of ADH-negative mutants.
The Adh gene from 4 formaldehyde-generated ADH-negative mutants of Drosophila melanogaster has been cloned and sequenced. All 4 mutants bear small deletions within the gene, ranging in size from 6 to 34 base pairs. 2 of the deletions lie within a 65-base pair intervening sequence and are accompanied by other aberrations. The other two are within the protein coding region of the gene. Some of these aberrations may be explained by a slipped mispairing mechanism.
D000426:Alcohol Dehydrogenase; D000429:Alcohol Oxidoreductases / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D004331:Drosophila melanogaster / Q000187:drug effects*; D005260:Female; D005557:Formaldehyde / Q000494:pharmacology*; D008297:Male; D009154:Mutation
D005557:Formaldehyde; D000429:Alcohol Oxidoreductases; D000426:Alcohol Dehydrogenase