Evidence of non-A, non-B hepatitis in children with acute leukemia and chronic liver disease.
Eleven children with acute lymphoblastic leukemia and chronic liver disease, who had negative reactions for hepatitis B virus markers in the liver, were studied at the time of therapy withdrawal for an antigen-antibody system linked to non-A, non-B (NANB) hepatitis infection. By immunofluorescence, six of the 11 children had a positive reaction for the NANB antigen in the liver, and five of these six children also had a positive reaction for the NANB antibody in serum. Histologic lesions were more severe in patients with the NANB antigen in the liver compared with those with a negative reaction.
D000293:Adolescent; D001707:Biopsy, Needle; D002648:Child; D002675:Child, Preschool; D005260:Female; D005455:Fluorescent Antibody Technique; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D006526:Hepatitis C / Q000150:complications* / Q000276:immunology; D006525:Hepatitis, Viral, Human / Q000150:complications*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications*; D008107:Liver Diseases / Q000209:etiology*; D008297:Male
D006514:Hepatitis B Surface Antigens