New evidence for the existence of HLA-B14 subtypes. Linkage with different DR antigens.
In a joint study 109 unrelated HLA-B14 positive individuals were subtyped for the provisional splits 14.1 and 14.2 respectively, based on sera of the 7th and 8th Histocompatibility Workshops. Sixty-eight of these donors as well as 23 families were also typed for DR antigens. Earlier findings concerning a linkage disequilibrium B14.1/Aw32 and B14.2/Aw33 were confirmed. In addition a highly significant association B14.1/DR7 as well as a less striking one for B14.2/DR1 were observed. These findings contribute new arguments for the partition of the B14 antigen.
D005802:Genes, MHC Class II; D008040:Genetic Linkage; D006680:HLA Antigens / Q000145:classification* / Q000235:genetics; D015235:HLA-B Antigens; D059909:HLA-B14 Antigen; D006684:HLA-DR Antigens; D015798:HLA-DR1 Antigen; D015809:HLA-DR7 Antigen; D006801:Humans
D006680:HLA Antigens; D015235:HLA-B Antigens; D059909:HLA-B14 Antigen; D006684:HLA-DR Antigens; D015798:HLA-DR1 Antigen; D015809:HLA-DR7 Antigen