Facilitation of sexual receptivity in the female rat by a fragment of the LHRH decapeptide, Ac-LHRH.
The following fragments of LHRH were administered intraventricularly and tested for their ability to enhance sexual receptivity in ovariectomized, estrogen-primed female rats: LHRH1-6 NH2, Ac-LHRH5-10, des-Tyr5-LHRH and des-Gly10-LHRH. LHRH1-6 NH2 had no effect on sexual behavior compared to saline-infused controls. Ac-LHRH5-10, des-Tyr5 LHRH and des-Gly10-LHRH significantly elevated lordotic responding compared to saline-infused controls. The results suggest that the elements contained in the LHRH structure may be functionally differentiated and indicate that the active sequence for facilitation of mating behavior is contained in the last half of the LHRH molecule.
D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000494:pharmacology*; D016729:Leuprolide; D007986:Luteinizing Hormone / Q000097:blood; D010446:Peptide Fragments / Q000494:pharmacology*; D011187:Posture; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D010446:Peptide Fragments; D007987:Gonadotropin-Releasing Hormone; C038430:LHRH (1-9); C038429:LHRH (1-6), GlyNH2(6)-; C038419:LHRH, des-Tyr(5)-; C038418:LHRH(5-10), Ac-; D007986:Luteinizing Hormone; D016729:Leuprolide; C009936:fertirelin