Topical pramoxine and hydrocortisone foam versus placebo in relief of post partum episiotomy symptoms and wound healing.
A double-blind randomised controlled trial, comparing pramoxine hydrochloride 1 per cent and hydrocortisone acetate 1 per cent in a mucoadhesive foam base, with simple aqueous foam (B.P.), in relieving episiotomy discomfort and episiotomy healing in 40 patients was carried out. Simple aqueous foam was more effective with regard to wound healing and episiotomy discomfort as measured by analgesic consumption. Pramoxine and hydrocortisone foam offers no advantage over simple aqueous foam in the treatment of post partum episiotomy discomfort.
D000287:Administration, Topical; D000700:Analgesics / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004841:Episiotomy; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009025:Morpholines / Q000008:administration & dosage / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000188:drug therapy*; D011897:Random Allocation; D014945:Wound Healing / Q000187:drug effects*
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D009025:Morpholines; C005548:pramoxine; C021650:hydrocortisone acetate; D006854:Hydrocortisone