[Resorption and formation in metastatic bone].
Bony metastases are a source of numerous complications and remain a difficult therapeutic target. Malignant cells implant in bony tissue where they can secrete factors which stimulate resorption and/or bone formation. The nature of these factors is now being discovered, even though their mode of action is better understood: the osteolytic action of prostaglandin E2 secreted in breast cancer, or the osteogenesis stimulating action of "transforming growth factor" in prostatic cancer. Progress in these areas of research is soon forthcoming due to new techniques in molecular biology.
D001859:Bone Neoplasms / Q000503:physiopathology / Q000556:secondary*; D001862:Bone Resorption; D006801:Humans; D009369:Neoplasms / Q000378:metabolism; D010006:Osteoblasts / Q000502:physiology; D010010:Osteoclasts / Q000502:physiology; D010012:Osteogenesis
Résorption et formation dans l'os métastatique.