Experience with the use of an intranasal LHRH analogue for the induction of puberty.
7 patients aged 16-25 years with hypogonadotrophic hypogonadism have been treated with 100 micrograms of a synthetic gonadotrophin-releasing hormone intranasal spray (HOE 766) on alternate days. In 1 patient, after an encouraging initial response there was a rapid decline in gonadotrophin responsiveness. 3 patients failed to show biochemical or clinical effects of treatment. 3 cases showed continuing responsiveness of gonadotrophin sex steroid levels to treatment for periods between 8 and 11 months.
D000281:Administration, Intranasal; D000293:Adolescent; D002648:Child; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000172:deficiency; D006062:Gonadotropins / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011627:Puberty / Q000187:drug effects*; D013739:Testosterone / Q000097:blood
D006062:Gonadotropins; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone