[Responses of isolated hepatic artery segments to barium in the presence of a flavonoid (4-methylesculetin), indomethacin and acetylsalicylate].
The aim of this work is to study the mechanism by which 4-methylesculetin (4-Me) inhibits the Ba++ induced contraction in smooth muscle. The effect of 4-Me, alone or associated with ascorbic acid, on basal tone and Ba++ induced contraction of isolated hepatic artery strips have been studied. Experiments have been carried out in the presence of lysine acetylsalicylate (LAS) and indomethacin (IN), specific inhibitors of prostaglandin-synthetase. Both LAS and IN suppressed the depressive effect of 4-Me on the Ba++ dependent contraction. Therefore, it seems reasonable to conclude that the 4-Me influence could be mediated by prostaglandins release smooth muscle.
D000818:Animals; D001241:Aspirin / Q000031:analogs & derivatives / Q000494:pharmacology*; D001464:Barium / Q000494:pharmacology*; D006499:Hepatic Artery / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology*; D008239:Lysine / Q000031:analogs & derivatives / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D012603:Scopoletin / Q000494:pharmacology*; D012756:Sheep; D014468:Umbelliferones / Q000494:pharmacology*
D014468:Umbelliferones; D001464:Barium; D008239:Lysine; D012603:Scopoletin; D001241:Aspirin; C010395:acetylsalicylic acid lysinate; D007213:Indomethacin
Risposte di segmenti di arteria epatica isolata al bario in presenza di un flavonoide (4-metilesculetolo) ed indometacina ed acetil-salicilato.