Enhancement of choline dehydrogenase activity in rat liver mitochondria by clofibrate feeding.
Male rats were fed a diet containing 0.75% clofibrate. After three weeks, the specific activity of choline dehydrogenase of a liver mitochondrial fraction was more then doubled. However, the activity of two other NAD-independent flavoenzymes of the inner mitochondrial membrane namely proline and succinate dehydrogenases were not altered significantly. Thus changes of the inner mitochondrial membrane induced by clofibrate seem to be restricted to some particular enzymes.
D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000818:Animals; D050545:Choline Dehydrogenase; D002994:Clofibrate / Q000494:pharmacology*; D004032:Diet; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology*; D011394:Proline Oxidase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000201:enzymology
D000429:Alcohol Oxidoreductases; D005993:Glycerolphosphate Dehydrogenase; D050545:Choline Dehydrogenase; D011394:Proline Oxidase; D002994:Clofibrate