Effect of isometamidium on infections by Trypanosoma vivax and T. evansi in experimentally-infected animals.
Assays dealing with the therapeutic and prophylactic activity of isometamidium on experimental infections by Trypanosoma vivax and T. evansi were carried out. The drug was found to be highly effective against T. vivax infection in sheep and cattle in which periods of protection ranging from 118 to 195 days were achieved. No complete effects against infection by T. evansi were observed. The drug was well tolerated in sheep and cattle while side-effects were noted in treated mares. It was concluded that isometamidium could be used to prevent damage and economical losses caused by T. vivax in Venezuela.
D000818:Animals; D002417:Cattle; D014355:Chagas Disease / Q000469:parasitology / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D006041:Goats; D006734:Horse Diseases / Q000469:parasitology / Q000517:prevention & control*; D006736:Horses; D008297:Male; D010617:Phenanthridines / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012376:Rodent Diseases / Q000469:parasitology / Q000517:prevention & control*; D013045:Species Specificity; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014345:Trypanosoma / Q000187:drug effects; D014354:Trypanosomiasis, Bovine / Q000469:parasitology / Q000517:prevention & control*
D010617:Phenanthridines; D014344:Trypanocidal Agents; C000702:isometamidium chloride