[Dark oxidation of unsaturated lipids and dihydroxy phenylalanine by photooxidized furocoumarins].
Well-known skin photosensitizers furocoumarins--psoralen, angelio in and 8-methoxypsoralen were shown to photosensitize oxidation of unsaturated lipids and dihydroxyphenylalanine via a two-step mechanism. At the first step (UV-irradiation at 366 nm) photooxidation of furocoumarins occurred, at the second step--the photooxidized furocoumarins oxidized unsaturated lipids or dihydroxyphenylalanine in darkness. The photochemical activity of furocoumarins in the two-step reaction decreased as follows: psoralen greater than angelicin greater than 8-methoxypsoralen. Similar photoreactions appear to participate in induction of phototoxic effects of furocoumarins.
D004295:Dihydroxyphenylalanine; D005231:Fatty Acids, Unsaturated; D005363:Ficusin; D011564:Furocoumarins; D008027:Light; D008730:Methoxsalen; D010084:Oxidation-Reduction; D010777:Photochemistry; D013329:Structure-Activity Relationship
D005231:Fatty Acids, Unsaturated; D011564:Furocoumarins; D004295:Dihydroxyphenylalanine; D005363:Ficusin; D008730:Methoxsalen
Temnovoe okislenie nenasyshchennykh lipidov i dioksifenilalanina fotookislennymi furokumarinami.