Effect of 6-hydroxydopamine on in vitro hippocampal corticosterone binding capacity in the male rat.
Adult male rats were injected with 6-hydroxydopamine, either into the lateral brain ventricle or directly into the dorsal hippocampus. They were adrenalectomized 5-7 days later, and following an additional 24 hours, the specific in vitro 3H-corticosterone binding capacity of dorsal hippocampal slices was determined by estimation of uptake of radioactivity by the nuclear fraction. Specific corticosterone binding was reduced by 40-50% in both experimental groups, as compared to vehicle-treated controls. These results suggest that the maintenance of normal dorsal hippocampal corticosterone binding capacity is dependent upon the integrity of endogenous brain catecholaminergic neural systems.
D000818:Animals; D003345:Corticosterone / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology*; D066298:In Vitro Techniques; D007267:Injections; D007276:Injections, Intraventricular; D008297:Male; D016627:Oxidopamine; D051381:Rats / Q000502:physiology*; D011919:Rats, Inbred Strains
D006892:Hydroxydopamines; D016627:Oxidopamine; D003345:Corticosterone