Mutagenicity of 2 anti-chagasic drugs and their metabolic deactivation.
2 anti-chagasic drugs, nifurtimox and benznidazole, were assayed in the Salmonella/mammalian microsome test. These drugs were most active in strain TA100. Under certain experimental conditions, addition of rat-liver S9 mix led to a decrease in the number of his+ revertants induced by the drugs.
D000818:Animals; D001711:Biotransformation; D014355:Chagas Disease; D006801:Humans; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D009547:Nifurtimox / Q000378:metabolism / Q000633:toxicity*; D009581:Nitrofurans / Q000633:toxicity*; D009593:Nitroimidazoles / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects; D014344:Trypanocidal Agents / Q000633:toxicity*
D009153:Mutagens; D009581:Nitrofurans; D009593:Nitroimidazoles; D014344:Trypanocidal Agents; D009547:Nifurtimox; C009999:benzonidazole