[Decreased acetylcholinesterase activity in the area of epileptogenic foci created by met-enkephalin in the hippocampus of rats].
Experiments on rats with electrochemotrodes implanted in the left and right hippocamp have shown that in epileptogenic foci created by microinjections of met-enkephalin or D-ala-2-met-enkephalin into the hippocamp, acetylcholinesterase activity (AChE) was diminished. It is assumed that reduction in AChE activity is an adaptive mechanism by which the excitability of hippocampal inhibitory basket cells, which are sensitive to acetylcholine, is increased.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D004569:Electroencephalography; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives / Q000494:pharmacology*; D004828:Epilepsies, Partial / Q000139:chemically induced / Q000201:enzymology; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000201:enzymology*
D004744:Enkephalin, Methionine; C013801:enkephalin-Met, Ala(2)-; D000110:Acetylcholinesterase
Snizhenie aktivnosti atsetilkholinesterazy v oblasti épileptogennykh ochagov, sozdannykh met-énkefalinom v gippokampe krys.