Stimulation of human chorionic gonadotropin and progesterone secretion by tumor promoters, phorbol ester and teleocidin B, in cultured choriocarcinoma cells.
Both 12-O-tetradecanoyl-phorbol-1- acetate and teleocidin B stimulated the secretion of human chorionic gonadotropin by cultured choriocarcinoma cells. These tumor promoters also stimulated production of progesterone in the cells. However, the 2 tumor promoters did not exert a marked effect on the cellular binding of epidermal growth factor that also had a stimulatory effect on production of these hormones.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D002273:Carcinogens / Q000494:pharmacology; D002460:Cell Line; D002822:Choriocarcinoma / Q000378:metabolism*; D006063:Chorionic Gonadotropin / Q000378:metabolism*; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005260:Female; D006801:Humans; D007700:Kinetics; D008235:Lyngbya Toxins; D008297:Male; D051379:Mice; D010704:Phorbols / Q000494:pharmacology*; D011247:Pregnancy; D011374:Progesterone / Q000378:metabolism*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014594:Uterine Neoplasms / Q000378:metabolism*
D000470:Alkaloids; D002273:Carcinogens; D006063:Chorionic Gonadotropin; D008235:Lyngbya Toxins; D010704:Phorbols; C022176:teleocidins; D011374:Progesterone; D004815:Epidermal Growth Factor; D013755:Tetradecanoylphorbol Acetate