Synergistic actions of prostacyclin and an isoquinoline derivative (CH-102) on ADP-induced aggregation of dog platelets in vitro.
The effect of an isoquinoline derivative, CH-102, and of prostacyclin-Na alone and their combinations on ADP-induced aggregation of dog platelets in vitro was studied. CH-102 and prostacyclin inhibited platelet aggregation in a dose-related manner with IC50 values of 3.2 X 10(-5) mol/l and of 4.8 X 10(-9) mol/l, respectively. CH-102 enhanced the platelet aggregation inhibitory effect of prostacyclin in a concentration range of 10(-6) to 2.3 X 10(-5) mol/l. The mode of interaction of the two agents characterized by the isobolic curve is a potentiated synergism.
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000818:Animals; D004285:Dogs; D004357:Drug Synergism; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*
D007546:Isoquinolines; D000244:Adenosine Diphosphate; C044684:CH 102; D011464:Epoprostenol