How glucagon-like is glucagon-like peptide-1?
Although glucagon-like peptide-1 has the appearance of a glucagon-homologue that may be co-secreted with glucagon, synthetic glucagon-like peptide-1-(1-37) does not significantly affect plasma glucose and insulin concentrations when administered at high doses (100 and 400 micrograms) to cortisone-pretreated rabbits. This synthetic preparation thus lacks the primary metabolic effect of glucagon at the doses tested. An intra- or extra-pancreatic role of glucagon-like peptide-1 has yet to be discovered.
D000595:Amino Acid Sequence; D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D005934:Glucagon / Q000494:pharmacology*; D052216:Glucagon-Like Peptide 1; D007328:Insulin / Q000097:blood*; D010455:Peptides / Q000494:pharmacology*; D011817:Rabbits; D013329:Structure-Activity Relationship
D001786:Blood Glucose; D005768:Gastrointestinal Hormones; D007328:Insulin; D010455:Peptides; D052216:Glucagon-Like Peptide 1; D005934:Glucagon