[Defect replacement with osteogenin containing gelatin].
In order to demonstrate an alternative way to correct diaphyseal defects allogenic cortical bone prepared as "osteogenin containing gelatine (OCG)" was used in sheep. Animals without any implants served as controls. Healing was assessed by radiological examination after 3, 6, 9 and 12 weeks and histological examination after 12 weeks. In the control group there was no bridging of the defect in all of the four animals. Out of the six animals of the OCG-group one animal suffered from a postoperative infection and one animal failed because of a breakdown of the osteosynthesis. The other four animals exhibited a complete reconstruction of the former defect roentgenologically after 9 weeks. Histologically a new formed spongious bone could be demonstrated in the former defective site. The OCG-implants were completely resorbed after 12 weeks.
D000818:Animals; D016025:Bone Transplantation; D005269:Femur / Q000601:surgery; D005593:Fracture Fixation, Internal; D010012:Osteogenesis; D010027:Osteotomy / Q000379:methods*; D012756:Sheep; D014945:Wound Healing
Defektersatz mit "Osteogenin-haltiger Gelatine (OCG)".