GABA-ergic drugs: effects on conditioning, memory and learning.
In order to study the role of GABA in behaviour, various GABA-mimetic and GABA-blocking drugs were tested for their effects on a conditioned avoidance response (CAR). Sodium valproate slowed the acquisition of CAR and failed to affect the latency of a well-learned CAR, but interestingly, showed a marked anti-conflict effect similar to that of benzodiazepine-derivatives. The similarity of effects of drugs such as benzodiazepines and sodium valproate, which are postulated to potentiate GABA-ergic transmission, suggests that GABA plays a role in conditioning, memory and learning.
D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects; D010205:Pantothenic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014635:Valproic Acid / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000502:physiology* / Q000031:analogs & derivatives
D000625:Aminooxyacetic Acid; C016030:pantogab; D010205:Pantothenic Acid; D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid; D010889:Piracetam