Influence of some sulfhydryl compounds on the antineoplastic effectiveness of 5-fluorouracil and 6-mercaptopurine.
The influence of three chosen model sulfhydryl groups containing compounds, characterized by increasing size of molecule--cysteine, glutathione and insulin on antineoplastic activity of 5-fluorouracil (5-FU) and 6-mercaptopurine (6-MP) against murine leukemia L-1210 5-FU and 6-MP and murine sarcoma Sa 180, was studied. Sulfhydryl compounds failed to change in most cases the therapeutic (antineoplastic) effect of 5-FU and 6-MP. However, certain doses of these sulfhydryl compounds enhanced the cytostatic effect of 6-MP in respect to Sa-180.
D000818:Animals; D003545:Cysteine / Q000494:pharmacology; D004357:Drug Synergism; D005472:Fluorouracil / Q000627:therapeutic use*; D005978:Glutathione / Q000494:pharmacology; D007328:Insulin / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy; D015122:Mercaptopurine / Q000627:therapeutic use*; D051379:Mice; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D012510:Sarcoma 180 / Q000188:drug therapy; D013438:Sulfhydryl Compounds / Q000494:pharmacology*
D007328:Insulin; D013438:Sulfhydryl Compounds; D015122:Mercaptopurine; D005978:Glutathione; D003545:Cysteine; D005472:Fluorouracil