Influence of excess of retinoid on DMBA carcinogenesis.
This paper reports a study on the influence of excess of vitamin A palmitate on the induction and maintenance of oral tumors. Sixty four weanling Syrian hamsters were divided in four groups and painted three times a week, either with 0.5% DMBA or 15% vitamin A palmitate, singly or in combination. A possible mild immune response evoked by vitamin A palmitate is considered responsible for the delayed induction of the tumors. In all animals exposed to carcinogen + vitamin A the induced tumors were small in size and histologically verified as well differentiated epidermoid carcinomas. In control group with sole vitamin A palmitate application the cheek pouch showed considerably increased keratinization.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D001551:Benz(a)Anthracenes / Q000633:toxicity*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000517:prevention & control / Q000648:ultrastructure; D002610:Cheek; D006224:Cricetinae; D004224:Diterpenes; D004848:Epithelium / Q000648:ultrastructure; D005260:Female; D008297:Male; D008647:Mesocricetus; D008854:Microscopy, Electron; D009062:Mouth Neoplasms / Q000139:chemically induced* / Q000517:prevention & control / Q000648:ultrastructure; D000084562:Retinyl Esters; D013997:Time Factors; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology
D001551:Benz(a)Anthracenes; D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C014794:retinol palmitate; D015127:9,10-Dimethyl-1,2-benzanthracene