Evaluation of cefamandole nafate for the treatment of acute gonococcal salpingitis.
Eighty-six women with suspected acute salpingitis were treated with parenteral cefamandole. From 53 (62%) of these Neisseria gonorrhoeae was recovered from an anogenital site(s) at admission. These women were younger, of lower parity, had pain for a shorter period of time, responded more rapidly to therapy, and required less antimicrobial agent for clinical cure than those from whom N gonorrhoeae was not recovered. The clinical success observed in these women was 94%, and only 2% of 122 gonococcal isolates were resistant to cefamandole in vitro.
D000293:Adolescent; D000328:Adult; D002435:Cefamandole / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002584:Cervix Uteri / Q000382:microbiology; D003268:Contraception Behavior; D005006:Ethnicity; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification; D010614:Pharynx / Q000382:microbiology; D012007:Rectum / Q000382:microbiology; D012488:Salpingitis / Q000188:drug therapy* / Q000382:microbiology; D014521:Urethra / Q000382:microbiology
D002511:Cephalosporins; D002435:Cefamandole; C012810:cefamandole nafate