Experimentally induced aneurysms of mesenterial arteries. Studies on the histogenesis of acquired aneurysm.
In previous studies (YAMAGUCHI et al. 1981 a, b) we administered vast amounts of Na2EDTA into the peritoneal cavity of guinea pigs and demonstrated multiple angiolytic changes of mesenterial arteries. In this experiment, with the same procedures, aneurysm formation of these arteries was encountered based on the above angiolysis. The vascular changes described may be induced by the same mechanisms which provoked angiolysis followed by loosening of elasticity, raised blood pressure and lack of surrounding support.
D000783:Aneurysm / Q000139:chemically induced / Q000473:pathology*; D000818:Animals; D004492:Edetic Acid; D004727:Endothelium / Q000473:pathology; D005260:Female; D006168:Guinea Pigs; D008297:Male; D008638:Mesenteric Arteries / Q000473:pathology*; D009131:Muscle, Smooth, Vascular / Q000473:pathology
D004492:Edetic Acid