Sezary's syndrome: T lymphocyte phenotyping of a skin biopsy using monoclonal antibodies.
By means of immunoperoxidase histochemistry through monoclonal antibodies, OKT3+ T cells were detected in the cutaneous lesion of a patient with Sezary syndrome. The majority of the infiltrating cells showed positive staining with OKT4 helper cell marker whereas a few OKT8+ cells were also seen. Many OKT6+ Langerhans' cells accumulated in the epidermis overlaying the dermal infiltrate.
D000368:Aged; D000911:Antibodies, Monoclonal; D001706:Biopsy; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D010641:Phenotype; D012751:Sezary Syndrome / Q000473:pathology*; D012867:Skin / Q000473:pathology*; D013601:T-Lymphocytes / Q000473:pathology*
D000911:Antibodies, Monoclonal