Absorption after subarachnoid and subdural administration of iohexol, 51Cr-EDTA, and 125I-albumin to rabbits.
The absorption of the nonionic contrast medium iohexol, the clearance tracer 51Cr-ethylenediaminetetraacetic acid, and the blood-pool marker 125I-human serum albumin was studied after subarachnoid and subdural injection in rabbits. Subdural deposition of the contrast medium and 51Cr-ethylenediaminetetraacetic acid resulted in a faster absorption rate and higher achieved blood levels than a subarachnoid injection of the two substances, where a slow absorption to lower blood concentrations was observed. No significant differences in absorption rate could be shown after subdural and subarachnoid administration of iodine-labelled albumin. The excretion of iohexol was observed for 1 week after the intrathecal injection. For both the subdural and subarachnoid depositions, about 83% of the injected iohexol was found in urine within 24 hr after injection. The total recovery of iohexol after 1 week was 96% (range, 87%-101%).
D000042:Absorption; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D003287:Contrast Media / Q000378:metabolism*; D004492:Edetic Acid / Q000378:metabolism*; D005260:Female; D007463:Iodobenzoates / Q000378:metabolism*; D007472:Iohexol; D008297:Male; D011817:Rabbits; D012711:Serum Albumin, Radio-Iodinated / Q000378:metabolism*; D013346:Subarachnoid Space; D013355:Subdural Space; D014283:Triiodobenzoic Acids / Q000378:metabolism*
D003287:Contrast Media; D007463:Iodobenzoates; D012711:Serum Albumin, Radio-Iodinated; D014283:Triiodobenzoic Acids; D007472:Iohexol; D004492:Edetic Acid