Inhibition of the promotion phase in two-step carcinogenesis in forestomach epithelium of mice by the aromatic retinoid etretinate.
Carcinogenesis induced by 7,12-dimethylbenz[a]anthracene (DMBA) and 12-O-tetradecanoylphorbol 13-acetate (TPA) in the forestomach epithelium of mice was delayed by ethyl all-trans-9-(4-methoxy-2,3,6-trimethylphenyl)-3,7-dimethyl-2,4,6,8-nonatetraenoate (etretinate). Beside the clear inhibitory effect during the promotion phase, however, considerable side effects occurred when administering effective doses.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens / Q000037:antagonists & inhibitors*; D004848:Epithelium / Q000187:drug effects; D005050:Etretinate / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors; D014212:Tretinoin / Q000031:analogs & derivatives*
D002273:Carcinogens; D014212:Tretinoin; D015127:9,10-Dimethyl-1,2-benzanthracene; D005050:Etretinate; D013755:Tetradecanoylphorbol Acetate