Sensitivities of wild-type and envelope-defective strains of Escherichia coli and Pseudomonas aeruginosa to antibacterial agents.
The sensitivities of Escherichia coli DCO (wild type) and DC2 (envelope mutant) and Pseudomonas aeruginosa 799 (wild-type) and 799/61 (envelope mutant) to preservatives and antibiotics have been determined. The outer membrane appears to play an important role in limiting the penetration of some, but not all, antibacterial agents.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002463:Cell Membrane Permeability; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D008826:Microbial Sensitivity Tests; D009154:Mutation; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000235:genetics; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents