[Effectiveness of non-steroidal anti-inflammatory and psychotropic drugs in patients with rheumatoid arthritis].
The authors provide the data on comparative efficacy of different non-steroidal anti-inflammatory agents (220 studies), psychotropic drugs (32 cases) and combined therapy (58 cases). All the studies were made by the double blind method with the use of placebo (38 cases). As for the psychotropic drugs, use was made of the tranquilizer relanium, mild activating neuroleptic sonapax, and tricyclic antidepressant amitriptyline. Combined therapy with nonsteroidal anti-inflammatory and psychotropic drugs appeared the most efficacious. It is suggested that this is connected both with potentiation of the analgesic effect of the antirheumatic drugs and with the action on the psychological distress playing a definite role in the disease development.
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006801:Humans; D011619:Psychotropic Drugs / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D011619:Psychotropic Drugs
Effektivnost' nesteroidnykh protivovospalitel'nykh i psikhotropnykh sredstv u bol'nykh revmatoidnym artritom.