A double-blind comparative study of Hexabrix and Renografin-76 in aortography and visceral arteriography.
A diatrizoate compound (Renografin-76) and low osmolality Hexabrix were compared in a double-blind study of 50 adults undergoing arteriographic examination. Subjective and objective assessment of pain reaction for each contrast injection rated lower overall for Hexabrix. Discomfort associated with Renografin was greatest for injections into extremity arteries. Hexabrix showed the least change in serum osmolality. No impairment of renal function was evidenced with either contrast media. No difference in the angiographic quality of the control agents was noted.
D000328:Adult; D000368:Aged; D000792:Angiography / Q000009:adverse effects; D001027:Aortography / Q000009:adverse effects; D002986:Clinical Trials as Topic; D003287:Contrast Media; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007463:Iodobenzoates; D007485:Ioxaglic Acid; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D014283:Triiodobenzoic Acids
D003287:Contrast Media; D004338:Drug Combinations; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; C027278:urovision; D007485:Ioxaglic Acid