Inhibition of ornithine decarboxylase in human fibroblast cells by type I and type II interferons.
Dilution of human fibroblast GM2767 cell cultures into fresh serum-containing growth medium induces ornithine decarboxylase activity 45-fold over a six-hour interval. When the fibroblast cultures are supplemented with human fibroblast alpha-, beta-, or gamma-interferon at the time of dilution into fresh growth medium, the induction of ornithine decarboxylase is inhibited 61%, 90%, and 65%, respectively. beta-Interferon is the most effective type of interferon to inhibit induction of ornithine decarboxylase.
D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D002478:Cells, Cultured; D004790:Enzyme Induction / Q000187:drug effects; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D065108:Ornithine Decarboxylase Inhibitors
D007370:Interferon Type I; D065108:Ornithine Decarboxylase Inhibitors; D007371:Interferon-gamma; D002262:Carboxy-Lyases