Tamm-Horsfall glycoprotein in human amniotic fluid.
Radioimmunoassay of material cross-reacting with urinary Tamm-Horsfall glycoprotein in human amniotic fluid was carried out. The cross-reacting material was shown to be identical with urinary Tamm-Horsfall glycoprotein by double immunodiffusion and by crossed immunoelectrophoresis. The concentrations of the substance from 16-25 weeks pregnancy were found to increase from average levels of 0.9 mg . l(-1) to 4.9 mg . 1(-1) over this period. The concentrations were considerably higher (up to 33 mg . l(-1) close to term. Measurements of the glycoprotein in amniotic fluid may be a useful index for development of renal function in the foetus.
D000328:Adult; D000653:Amniotic Fluid / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D006801:Humans; D005779:Immunodiffusion; D007123:Immunoelectrophoresis, Two-Dimensional; D009088:Mucoproteins / Q000378:metabolism*; D011247:Pregnancy; D011863:Radioimmunoassay; D058949:Uromodulin
D009088:Mucoproteins; C548612:UMOD protein, human; D058949:Uromodulin