[Cell biology basis of IgE antibody regulation. Immunotherapeutic approaches].
Recent developments as to the IgE-antibody synthesis in rodents and in the human model are summarized and discussed in reference to our own data. It is by now established that the IgE-antibody response is regulated by interdependent interactions of cellular, humoral and genetic factors. The IgE-bearing B-lymphocyte develops from a surface IgM carrying B-lymphocyte. The transformation into an IgE secreting plasma cell requires T-cell help or soluble T-cell factors. Recent advances in the characterization of human lymphocytes as well as more sophisticated cell biological approaches facilitated the analysis of IgE-antibody synthesis in the human in vitro model. In most of the studies at present available the effect of the polyclonal B-cell mitogen (PWM) was analyzed. PWM either enhanced, suppressed or unlike to other Ig-classes did not affect the IgE-antibody synthesis at all. Immunotherapeutic approaches have to consider to establish the allergen induced in vitro model of IgE-antibody synthesis in humans, to modulate the interactions of T-helper and/or suppressor cells or to generate soluble suppressor factors. In any case the analysis of the IgE-antibody synthesis in humans could be a valuable tool to assess IgE-B-cell memory towards various allergens and to determine the IgE-mediated in patients.
D000818:Animals; D001249:Asthma / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D005802:Genes, MHC Class II; D006801:Humans; D007111:Immunity, Cellular; D007073:Immunoglobulin E / Q000032:analysis / Q000096:biosynthesis* / Q000235:genetics; D007074:Immunoglobulin G / Q000096:biosynthesis; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000502:physiology; D007167:Immunotherapy; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D051379:Mice; D009930:Organic Chemicals; D011043:Pokeweed Mitogens / Q000494:pharmacology; D051381:Rats; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology
D007074:Immunoglobulin G; D007166:Immunosuppressive Agents; D009930:Organic Chemicals; D011043:Pokeweed Mitogens; C023051:suppressive factor of allergy; D007073:Immunoglobulin E
Zellbiologische Grundlagen der IgE-Antikörperregulation. Immuntherapeutische Ansatzpunkte.