[Cross-reacting antigen of Streptococcus group A and of the stromal fibroblasts of lymphoid organs].
It has been demonstrated by the indirect immunofluorescent method that sera of rabbits immunized with nontype-specific (NTS) proteins of the group A streptococcal cell wall react with cultivated fibroblasts. These fibroblasts were explanted from human and guinea-pig lymphoid organs. The same reactions were observed with F(ab')2 fragments of IgG obtained from antisera to NTS-proteins. Fractions containing NTS-antigens inhibited these reactions. A possible role of the cross-reactive streptococcal antigen in common with the antigen of lymphoid organs during thymic damage and the development of the autoimmune process in rheumatic fever is discussed.
D000818:Animals; D000941:Antigens / Q000032:analysis*; D000942:Antigens, Bacterial / Q000032:analysis*; D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules; D002478:Cells, Cultured; D003429:Cross Reactions; D005347:Fibroblasts / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006023:Glycoproteins / Q000032:analysis; D006168:Guinea Pigs; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000032:analysis; D008221:Lymphoid Tissue / Q000276:immunology*; D013297:Streptococcus pyogenes / Q000276:immunology*
D000941:Antigens; D000942:Antigens, Bacterial; D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules; D006023:Glycoproteins; D007140:Immunoglobulin Fab Fragments
Perekrestno reagiruiushchiĭ antigen sterptokokka gruppy A i stromal'nykh fibroblastov limfoidnykh organov.