Specific inhibition of vaccinia virus growth by 2'-O-methyladenosine: isolation of a drug-resistant virus mutant.
2'-O-methyladenosine (Am) specifically inhibits growth of vaccinia virus on cultured monkey kidney (BSC40) cells. Specificity has been demonstrated by the isolation of an Am-resistant mutant of vaccinia which forms plaques on Am-treated monolayers of BSC40 cells under conditions where wild type (wt) plaque formation is inhibited. Am inhibits virus growth at an early stage of infection; host shut off and early virus protein synthesis are inhibited by the drug.
D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D004352:Drug Resistance, Microbial; D005814:Genes, Viral; D000882:Haplorhini; D009154:Mutation; D014616:Vaccinia virus / Q000187:drug effects* / Q000235:genetics / Q000302:isolation & purification; D010948:Viral Plaque Assay; D014764:Viral Proteins / Q000096:biosynthesis; D014779:Virus Replication / Q000187:drug effects
D014764:Viral Proteins; C024341:2'-O-methyladenosine; D000241:Adenosine