[Presence of a substance immunologically related to somaliberin extracted from human pancreatic tumor (hpGRF) in neurons of the hypophysiotropic area in the guinea-pig and rat].
An antiserum raised against the synthetic human pancreatic tumour GRF (hpGRF) made it possible to localize an immunoreactive material in 100 nm granules of nerve terminals distributed in the external layer of the median eminence in Guinea-Pig and Rat. Moreover, especially in colchicine-treated Guinea-Pigs, numerous stained perikarya were observed, exclusively located in the arcuate nucleus. These results suggest that hypothalamic GRF is very similar, if not identical, to hpGRF.
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000032:analysis; D003078:Colchicine / Q000494:pharmacology; D013007:Growth Hormone-Releasing Hormone / Q000032:analysis* / Q000276:immunology; D006168:Guinea Pigs; D006801:Humans; D007033:Hypothalamus, Middle / Q000032:analysis* / Q000166:cytology; D007120:Immunochemistry; D008297:Male; D009474:Neurons / Q000032:analysis* / Q000187:drug effects; D009489:Neurosecretion; D010286:Paraventricular Hypothalamic Nucleus / Q000032:analysis; D051381:Rats; D013045:Species Specificity
D013007:Growth Hormone-Releasing Hormone; D003078:Colchicine
Présence d'une substance immunologiquement apparentée à la somatolibérine extraite d'une tumeur pancréatique humaine (hpGRF) dans des neurones de l'aire hypophysiotrope du Cobaye et du Rat.