Antishock effect of gabexate mesilate (FOY).
The antishock effects of gabexate mesilate (FOY) were investigated in rats subjected to hemorrhagic hypotension, with particular attention focused on the stabilizing effects of hepatic lysosomes. The survival time of rats treated with FOY, infused for 2 hours intravenously at a rate of 50 mg/kg/hr, was significantly prolonged, accompanied by a tendency to decreased activity of plasma lysosomal enzymes. FOY, at a concentration of 10(-3) M, exerted a significant decrease in the extralysosomal release of acid phosphatase (15%, P less than 0.05), beta-glucuronidase (25%, P less than 0.05) and cathepsin D (25%, P less than 0.02) following hyposmotic labilization of lysosomes. Although the release of lysosomal enzymes might be counterbalanced by 50 mg/kg/hr of FOY, favorable cytochemical findings indicating stabilization of lysosomal membranes were consistently observed. The data suggest that FOY has antishock properties, and that these properties are caused, at least partially, by the stabilization of lysosomes.
D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D002402:Cathepsin D; D002403:Cathepsins / Q000032:analysis; D016670:Gabexate; D005966:Glucuronidase / Q000032:analysis; D006146:Guanidines / Q000494:pharmacology / Q000627:therapeutic use*; D007425:Intracellular Membranes / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008247:Lysosomes / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012771:Shock, Hemorrhagic / Q000188:drug therapy*
D006146:Guanidines; D016670:Gabexate; D000135:Acid Phosphatase; D005966:Glucuronidase; D002403:Cathepsins; D002402:Cathepsin D