Haemodynamic effects of nifedipine, nitroglycerine and prazosin in pulmonary hypertension following ingestion of toxic oil.
The haemodynamic effect of several vasodilators was studied in 15 patients with pulmonary hypertension of recent onset secondary to ingestion of toxic oil. Right heart catheterization was performed by means of a Swan-Ganz thermodilution catheter. Mean pulmonary artery pressure (PAP) was higher than 25 mmHg in every patient. Haemodynamic monitoring was maintained for 2-3 days and three drugs were administered. Nifedipine (10 mg sublingual plus 20 mg p.o.) produced slight reductions in PAP and pulmonary artery resistance (PAR) at some time after drug administration. These changes were minimal and the drug was not considered useful. Nitroglycerine ointment (20-25 mg) produced a significant decline in PAP and PAR throughout six hours although prominent changes occurred only at the first hour. Prazosin (5-10 mg p.o.) induced a significant decline in PAR and PAP throughout 6 hours. The effect of this drug was more prominent than that of nitroglycerine.
D000293:Adolescent; D000328:Adult; D002648:Child; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology*; D005996:Nitroglycerin / Q000494:pharmacology*; D009821:Oils / Q000009:adverse effects; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011224:Prazosin / Q000494:pharmacology*; D011799:Quinazolines / Q000494:pharmacology*
D009821:Oils; D011799:Quinazolines; D005996:Nitroglycerin; D009543:Nifedipine; D010100:Oxygen; D011224:Prazosin