Dimethyl sulphoxide (DMSO) induced serum hyperosmolality.
We describe a patient who received intravenous dimethyl sulphoxide (DMSO) (as part of an experimental protocol) to control increased intracranial pressure. The patient died of a brain abscess. She developed extreme serum hyperosmolality from the DMSO with the osmolality peaking at 717 mosmol/kg. DMSO may induce extreme serum hyperosmolality and should be utilized cautiously.
D000293:Adolescent; D001922:Brain Abscess / Q000150:complications; D004121:Dimethyl Sulfoxide / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects; D008353:Mannitol / Q000627:therapeutic use; D009994:Osmolar Concentration; D011247:Pregnancy; D014883:Water-Electrolyte Imbalance / Q000139:chemically induced*
D008353:Mannitol; D004121:Dimethyl Sulfoxide