11 beta-Hydroxysteroid dehydrogenase: fact or fancy?
Previous attempts to explain the diverse behavior of 11 beta-hydroxysteroid dehydrogenase (11-HSD) within and between species have not been successful. We now propose that 11-HSD activity is the resultant of the coordinated interaction of two enzyme types, 11-dehydrogenase and 11-reductase. We have demonstrated their separate existence by physico-chemical and kinetic methods. Based on these findings, two classes of disease in humans that have been recently described can now be characterized as being associated with a deficiency in either 11-dehydrogenase or 11-reductase.
D042842:11-beta-Hydroxysteroid Dehydrogenases; D000305:Adrenal Cortex Hormones / Q000494:pharmacology; D000818:Animals; D003348:Cortisone / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism; D006728:Hormones / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D006913:Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors / Q000172:deficiency / Q000378:metabolism*; D010084:Oxidation-Reduction; D011247:Pregnancy; D013045:Species Specificity; D013963:Thyroid Hormones / Q000494:pharmacology; D014018:Tissue Distribution
D000305:Adrenal Cortex Hormones; D006728:Hormones; D013963:Thyroid Hormones; D006913:Hydroxysteroid Dehydrogenases; D042842:11-beta-Hydroxysteroid Dehydrogenases; D003348:Cortisone; D006854:Hydrocortisone