[In vitro regulation of the secretion of thymulin (STF) by human thymic epithelial cells].
The presence of thymulin (formerly called Facteur Thymique Sérique, FTS) in cultured human thymic epithelial cells was studied using a monoclonal anti-thymulin antibody in an immunofluorescence technique. The percentage of thymulin-containing cells increases gradually as a function of time, from 10% at day 4 to 90% at day 14. Furthermore, this increase can be prevented by the addition of thymulin in the culture medium. These data suggest a feedback control of thymulin secretion by thymic epithelial cells.
D000911:Antibodies, Monoclonal; D002478:Cells, Cultured; D004848:Epithelium / Q000378:metabolism; D005455:Fluorescent Antibody Technique; D006801:Humans; D007700:Kinetics; D013935:Thymic Factor, Circulating / Q000378:metabolism*; D013950:Thymus Gland / Q000378:metabolism*; D013951:Thymus Hormones / Q000378:metabolism*
D000911:Antibodies, Monoclonal; D013951:Thymus Hormones; D013935:Thymic Factor, Circulating
Régulation in vitro de la sécrétion de thymuline (FTS) par les cellules épithéliales thymiques humaines.