The effect of polyethylene glycol-200 on metabolic acidosis induced by chloralose anaesthesia.
Chloralose may be used in a 10% solution as an anaesthetic in dogs. The solubility of chloralose was found to be much higher in polyethylene glycol-200 (PEG-200) than in either warm (body temperature) or cold saline (0.9% NaCl). The intravenous (i.v.) administration of chloralose in warm saline solution induced acidosis as a result of the increase in the level of metabolic acids. The acidity generated by chloralose in almost neutral saline was probably the result of increase in the base deficit in the animal. The infusion of PEG-200 (almost neutral) significantly reduced the base deficit without disturbing the PaO2 or PaCO2 in the arterial blood. The base deficit value was significantly lower after administration of chloralose solution in PEG-200 (almost neutral) than after administration in saline. The use of PEG-200 as a solvent for chloralose was advantageous in two ways. Firstly, it prevented the production of acids in anaesthetic solution and neutralized the blood metabolic acids generated by chloralose administration in saline. Secondly, the solubility of chloralose (10% w/v solution) in PEG-200 was very much higher than in warm or cold saline.
D000138:Acidosis / Q000139:chemically induced / Q000662:veterinary*; D000758:Anesthesia / Q000009:adverse effects / Q000662:veterinary*; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D002698:Chloralose / Q000008:administration & dosage / Q000009:adverse effects*; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D006863:Hydrogen-Ion Concentration; D011092:Polyethylene Glycols / Q000494:pharmacology*
D002245:Carbon Dioxide; D002698:Chloralose; D011092:Polyethylene Glycols