Improved glucose tolerance in gestational diabetic women on a low fat, high unrefined carbohydrate diet.
In a randomized cross-over study 5 gestational diabetic women were tested on a low fat, high unrefined carbohydrate (HC) diet and a low carbohydrate (LC) diet for a period of 4 days each. Glucose tolerance was shown to be significantly improved on the HC diet compared to the LC diet (p less than 0.05). Urinary glucose output was 50% lower on the HC diet (1.3 +/- 1.1 mmol/d) than on the LC diet (2.6 +/- 3.0 mmol/d), although this difference was not statistically significant. Fasting free fatty acid levels were significantly lower on the HC diet (HC 590 +/- 270 mumol/l, LC 690 +/- 270 mumol/l; p less than 0.02); as were the fasting cholesterol levels (HC 5.9 +/- 1.1 mmol/l, LC 6.3 +/- 1.1 mmol/l; p less than 0.01). Fasting plasma glucose, 2 h postprandial plasma glucose, and fasting plasma triglyceride levels did not differ on the 2 diets. These pilot study results suggest that diets low in fat and high in unrefined carbohydrate content are beneficial to the management of women with gestational diabetes.
D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003927:Diet, Diabetic; D004040:Dietary Carbohydrates / Q000008:administration & dosage* / Q000378:metabolism; D004041:Dietary Fats / Q000008:administration & dosage* / Q000378:metabolism; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005947:Glucose / Q000378:metabolism*; D005951:Glucose Tolerance Test; D006029:Glycosuria / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000097:blood; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000178:diet therapy / Q000378:metabolism*; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D014280:Triglycerides; D002784:Cholesterol; D005947:Glucose