Effect of fatty acid anilides on the generation of arachidonic acid by human polymorphonuclear leukocytes.
The addition of oleoylanilide or linoleylanilide to human polymorphonuclear leukocytes induces a time- and dose-dependent generation of arachidonic acid. Half-maximal effect is caused by a dose of 0.2 mg linoleylanilide/ml. Fatty acid anilides also produce a time- and dose-dependent inhibition of the synthesis of triacylglycerol. Half-maximal effect is caused by 1 microgram linoleylanilide/ml. These results indicate that fatty acid anilides, which have been found in the illegal cooking oil which intoxicated thousands of Spaniards, alter lipid metabolism in human polymorphonuclear leukocytes.
D000813:Anilides / Q000494:pharmacology*; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D000001:Calcimycin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007700:Kinetics; D008041:Linoleic Acids / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D009829:Oleic Acids / Q000494:pharmacology*; D014280:Triglycerides / Q000096:biosynthesis; D015054:Zymosan / Q000494:pharmacology
D000813:Anilides; D001095:Arachidonic Acids; D008041:Linoleic Acids; D009829:Oleic Acids; D014280:Triglycerides; C039294:linoleylanilide; D016718:Arachidonic Acid; D000001:Calcimycin; C038731:oleoylanilide; D015054:Zymosan