[Detection of cellular sensitization in mice after treatment with chemical carcinogens].
Mice were treated epicutaneously (DMBA, benzene) and subcutaneously (BP, MNH) with chemical carcinogens. As detected by the MEM-test a cellular sensitization developed against fetal antigens, which are present in 3M KCl-extracts of mouse fetal tissue. The sensitization was detected before formation of tumors occurred. The conclusion was drawn that sensitization to fetal antigens is not a characteristic feature of tumor-bearing animals.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology; D000818:Animals; D000954:Antigens, Surface / Q000276:immunology*; D001554:Benzene / Q000494:pharmacology; D001580:Benzopyrenes / Q000494:pharmacology; D002273:Carcinogens / Q000494:pharmacology*; D002478:Cells, Cultured; D005326:Fetal Proteins / Q000276:immunology*; D007111:Immunity, Cellular / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D008770:Methylnitrosourea / Q000494:pharmacology; D051379:Mice
D000954:Antigens, Surface; D001580:Benzopyrenes; D002273:Carcinogens; D005326:Fetal Proteins; D015127:9,10-Dimethyl-1,2-benzanthracene; D008770:Methylnitrosourea; D001554:Benzene
Der Nachweis zellulärer Sensibilisierungen bei Mäusen nach der Behandlung mit chemischen Kanzerogenen.