HLA-DR antigens in Mexican patients with Guillain-Barré syndrome.
The distribution of HLA-DR antigens was investigated in 38 Mexican Mestizo patients with Guillain-Barré syndrome (GBS) and in 100 healthy controls belonging to the same population. IgG, IgM, IgA, CH50, C3, C4 and the number of T and B lymphocytes were also evaluated in the patients. Only DR3 was significantly increased in the patients (Yates' chi 2 = 9.943, Pc = 0.014) and the relative risk for developing the disease was 3.49. These findings support the hypothesis that DR3 or a closely linked Ir gene may play some role in the susceptibility to GBS.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005802:Genes, MHC Class II; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D008297:Male; D008800:Mexico; D008875:Middle Aged; D011129:Polyradiculoneuropathy / Q000235:genetics / Q000276:immunology*
D000949:Histocompatibility Antigens Class II