Positive inotropic and chronotropic effect of alloimmune sera on isolated mouse atria.
The effects of alloimmune sera on the contractile tension and frequency of spontaneously beating isolated mouse atria were explored. Immune sera enhanced frequency as well as tension; both effects were blocked by the presence of propranolol. In contrast, pretreatment with 6-OH dopamine potentiated the stimulatory action of immune sera.
D000818:Animals; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D006892:Hydroxydopamines / Q000494:pharmacology; D007106:Immune Sera / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009200:Myocardial Contraction / Q000187:drug effects*; D016627:Oxidopamine; D011433:Propranolol / Q000494:pharmacology; D013268:Stimulation, Chemical
D006892:Hydroxydopamines; D007106:Immune Sera; D016627:Oxidopamine; D011433:Propranolol