Potentiation of duodenal ulcerogenic action of acrylonitrile by PCB or phenobarbital in the rat.
Pretreatment of rats with the polychlorinated biphenyl (PCB) Aroclor 1254 or phenobarbital markedly increased the duodenal ulcerogenic action of acrylonitrile. The extent of forestomach and hepatic lesions in these rats, on the other hand, was not modified. The duodenal ulcers produced by Aroclor 1254 and acrylonitrile morphologically resembled the ulcers induced in other animal models of the human duodenal ulcer disease. The possible mechanisms of this potentiation of acrylonitrile action are discussed.
D000181:Acrylonitrile / Q000633:toxicity*; D000818:Animals; D001140:Aroclors / Q000494:pharmacology*; D020111:Chlorodiphenyl (54% Chlorine); D004357:Drug Synergism; D004381:Duodenal Ulcer / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009570:Nitriles / Q000633:toxicity*; D010634:Phenobarbital / Q000494:pharmacology*; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000473:pathology
D001140:Aroclors; D009570:Nitriles; D020111:Chlorodiphenyl (54% Chlorine); D011078:Polychlorinated Biphenyls; D000181:Acrylonitrile; D010634:Phenobarbital