Restoration of phagocytosis and oxidative metabolism by Piracetam in failing human neutrophils: a qualitative assessment.
By the use of immunobeads, a convenient clinical laboratory test is available which detects, in metabolically stressed leukocytes, failing or absent phagocytosis and/or impaired to absent oxidative metabolic activity. Furthermore, it has been demonstrated that Piracetam, 2-oxo-pyrrolidine acetamide, will restore such compromised neutrophils to normal functional status. In 4 of 19 patients, all with a variety of serious diseases, a range from impaired to total failure of neutrophilic phagocytic and metabolic oxidative activities was detected by the test. Piracetam, as shown by qualitative methods, restored to optimal activity the two impaired neutrophil functions in these 4 patients. Quantitative techniques are available currently to establish the beneficial effect of Piracetam on such defective neutrophils. Piracetam merits additional study to determine its efficacy in enhancement of restorative effects on compromised neutrophils which have been observed. The clinical promise of this investigation offers benefit to some patients now jeopardized by certain stressful diseases in part due to agonal failure of neutrophils.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D007562:Creutzfeldt-Jakob Syndrome / Q000097:blood / Q000150:complications; D016883:Diabetic Ketoacidosis / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*; D010100:Oxygen / Q000097:blood*; D010587:Phagocytosis / Q000187:drug effects*; D010889:Piracetam; D011008:Pneumococcal Infections / Q000097:blood / Q000150:complications; D011019:Pneumonia, Mycoplasma / Q000097:blood / Q000150:complications; D011760:Pyrrolidinones; D014376:Tuberculosis / Q000097:blood / Q000150:complications
D011760:Pyrrolidinones; D010100:Oxygen; D010889:Piracetam