Delayed effects of drug exposure during pregnancy: reproductive function.
This article reviews the delayed effects of anticonvulsants (phenobarbital, phenytoin, and valproate) administered in utero upon the reproductive function in the offspring. Experimental data from the authors' laboratories are discussed in light of this context. Furthermore, comments are made emphasizing the gaps in our knowledge concerning the problem of drug exposure during pregnancy and the complex nature of drug effects upon the reproductive system.
D000818:Animals; D000927:Anticonvulsants / Q000009:adverse effects*; D004971:Estrus / Q000187:drug effects; D005260:Female; D005298:Fertility / Q000187:drug effects; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects; D010672:Phenytoin / Q000009:adverse effects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D012741:Sexual Maturation / Q000187:drug effects; D013739:Testosterone / Q000378:metabolism; D014635:Valproic Acid / Q000009:adverse effects
D000927:Anticonvulsants; D013739:Testosterone; D014635:Valproic Acid; D010672:Phenytoin; D007986:Luteinizing Hormone; D010634:Phenobarbital