Donor-to-host transmission of streptococcal infection by corneas stored in McCarey-Kaufman medium.
Two patients developed streptococcal endophthalmitis following penetrating keratoplasty. These cases may represent the third and fourth cases of donor-to-host transmission of streptococcal infection by corneas stored in McCarey-Kaufman (M-K) medium. Streptococcal agents now account for 50-59% of the total number of reported cases of M-K medium contamination by donor tissue with resultant infection in the host. Gentamicin sulfate, the sole antibiotic used in the M-K medium in all cases, has poor activity against most streptococci. The addition of a second antibiotic to the M-K medium to provide an improved spectrum of antimicrobial activity should be considered.
D000368:Aged; D003315:Cornea / Q000382:microbiology; D016039:Corneal Transplantation; D009877:Endophthalmitis / Q000382:microbiology / Q000635:transmission*; D005260:Female; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D013290:Streptococcal Infections / Q000382:microbiology / Q000635:transmission*; D013291:Streptococcus / Q000187:drug effects; D014019:Tissue Donors; D014021:Tissue Preservation / Q000379:methods
D005839:Gentamicins