[Long-term treatment with a new antihypertensive drug: flutonidin].
The aim of this research was to evaluate the effectiveness and the tolerability of flutonidin: a new clonidine-like antihypertensive compound. 30 patients (9 man and 21 women, mean age 60.5), affected by mild-moderate essential hypertension, have been randomized in two homogeneous groups of 15 patients, and treated respectively with flutonidin (F) 2 mg/day and clonidine (C) 0.3 mg/day for a period of 15 days at the Hospital. We obtained 60% normalization of blood pressure values in patients of group F and 66% in the patients of group C. The treatment continued after discharge from Hospital at the same doses for a six months period in the 9 normalized patients of group F and in the 10 normalized patients of group C. The results showed an increase of the blood pressure mean values in both groups. Our data seem to indicate that: 1) Flutonidin and clonidine have comparable antihypertensive effect. 2) A partial loss of activity has been observed for both drugs. This phenomenon has been already noted in long-term treatment with clonidine. 3) The tolerability of two compounds resulted satisfactory.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D003000:Clonidine / Q000627:therapeutic use; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007093:Imidazoles / Q000627:therapeutic use*; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged
D007093:Imidazoles; D003000:Clonidine; C010227:flutonidine
Trattamento a lungo termine con un nuovo farmaco antiipertensivo: flutonidin.