An example of major histocompatibility complex-linked control of idiotypic interactions.
Normal euthymic mice, injected i.v. with low doses of syngeneic monoclonal antibodies carrying "recurrent" idiotypes, develop a specific increase in numbers of splenic IgM plaque-forming cells that are paratopically and idiotypically similar to the injected antibody. We have now studied the responsiveness to a C57BL/6 anti-dextran a(1 leads to 6) and BALB/c anti-TNP (trinitrophenyl) monoclonal antibodies in a variety of strains. It was found that such responses are controlled by two linkage groups, namely major histocompatibility complex (MHC) and Ig-1.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000235:genetics / Q000276:immunology; D000921:Antibody-Producing Cells / Q000276:immunology; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D007130:Immunoglobulin Idiotypes / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008814:Mice, Inbred NZB
D000911:Antibodies, Monoclonal; D006183:H-2 Antigens; D007130:Immunoglobulin Idiotypes