[Clinical experimental studies of postoperative infusion analgesia].
30 postoperative patients, who had undergone abdominal gynaecological surgery with standard general anaesthesia were randomly divided into three groups and received, in the recovery ward, a continuous infusion of either pentazocine, piritramid, or ketamine. The patients rated their pain on a 15 cm pain analogue score. Group I pentazocine: Mean dosage on the day of operation 0.12 mg/kg/h, 0.1 mg/kg/h on the first and only 0.07 mg/kg/h on the second postoperative day. Pentazocine blood levels were on average 50 micrograms/l. Group II piritramid: Mean dosage on the day of operation 0.038 mg/kg/h, 0.024 mg/kg/h on the first and 0.019 mg/kg/h on the second postoperative day. Blood levels of piritramid were not determined because there is no satisfactory assay available. Group III ketamine: mean dosage on the day of operation 0.32 mg/kg/h, 0.28 mg/kg/h on the first and 0.29 mg/kg/h on the second postoperative day. Ketamine blood levels lay between 120 and 180 micrograms/l. The three analgesics did not cause any important haemodynamic or respiratory side effects. Pentazocine and piritramid were the most effective analgesics, ketamine was the least effective with a high incidence of side effects.
D000328:Adult; D000700:Analgesics / Q000008:administration & dosage*; D002245:Carbon Dioxide / Q000097:blood; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007649:Ketamine / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D010423:Pentazocine / Q000008:administration & dosage / Q000009:adverse effects; D010892:Pirinitramide / Q000008:administration & dosage / Q000009:adverse effects
D000700:Analgesics; D002245:Carbon Dioxide; D010892:Pirinitramide; D007649:Ketamine; D010423:Pentazocine
Klinisch experimentelle Untersuchungen zur postoperativen Infusionsanalgesie.