Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets.
Platelet-activating factor stimulates phosphatidylinositol turnover in human platelets as indicated by [32P]phosphatidate accumulation in platelets pre-labelled with [32P]Pi, and by [3H]phosphatidate accumulation and [3H]phosphatidylinositol loss in platelets pre-labelled with [3H]arachidonate. These effects of platelet-activating factor are direct and are independent of the production and/or release of endogenous platelet agonists such as ADP, 5-hydroxytryptamine and thromboxane A2.
D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001792:Blood Platelets / Q000378:metabolism*; D006801:Humans; D010716:Phosphatidylinositols / Q000097:blood*; D010743:Phospholipids / Q000097:blood; D010972:Platelet Activating Factor; D010974:Platelet Aggregation; D013997:Time Factors
D001095:Arachidonic Acids; D010716:Phosphatidylinositols; D010743:Phospholipids; D010972:Platelet Activating Factor; D016718:Arachidonic Acid