Natural and acquired resistance of mice to infection by airborne Klebsiella pneumoniae after subchronic intoxication by cadmium administered orally.
Mice daily ingested about 22 mg of cadmium per kg of body weight in drinking water for 30 days. On the 30th day, the liver and kidneys of the mice contained about 18 micrograms of Cd2+ per g of fresh organ. A group of these mice was immunized against Klebsiella pneumoniae using two injections of vaccine, the first on the 7th day and the second on the 14th day of intoxication. On the 28th day, the non-immunized and the immunized mice were infected via a respiratory route by one lethal dose 50% of K. pneumoniae (the LD50 for the immunized mice was 2.4 times higher than the LD50 for the non-immunized mice). Comparison with the non-intoxicated control mice showed that the ingestion of Cd2+ did not significantly modify the natural resistance or the acquired resistance of the mice to the infection by airborne K. pneumoniae.
D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D007109:Immunity / Q000187:drug effects*; D007113:Immunity, Innate / Q000187:drug effects; D007114:Immunization; D007710:Klebsiella Infections / Q000276:immunology*; D007711:Klebsiella pneumoniae / Q000276:immunology; D008297:Male; D051379:Mice
D002104:Cadmium