[Demonstration of a bacterial structure in two human mediators: a sleep facilitating factor and a monokine].
A monoclonal anti-MDP antibody was found to bind to "Slow Wave Sleep" factor. This result confirms that this factor is a muramyl peptide and furthermore shows that it contains a structure characteristic of the synthetic adjuvant and of the bacterial cell wall, i.e. an acetylated muramic acid bound to L-alanine. This antibody was also shown to specifically inhibit a biological activity of a purified human monokine which induces fever. Because of these results and other recent observations we propose that a bacterial structure is present in certain mammalian mediators.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000032:analysis*; D000818:Animals; D000911:Antibodies, Monoclonal; D004261:DNA Replication / Q000187:drug effects; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008262:Macrophage Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D015846:Monokines; D011506:Proteins / Q000032:analysis* / Q000494:pharmacology; D012890:Sleep
D000911:Antibodies, Monoclonal; D015846:Monokines; D011506:Proteins; D000119:Acetylmuramyl-Alanyl-Isoglutamine
Mise en évidence d'une structure bactérienne dans deux médiateurs humains: un facteur favorisant le sommeil et une monokine.