The stacking interactions in 7-methylguanine-tryptophan systems, a model study for the interaction between the 'cap' structure of mRNA and its binding protein.
Stacking interactions were shown by spectroscopic and X-ray crystallographic studies to be formed between the tryptophan and the protonated 7-methylguanine derivatives. These interactions would be in part responsible for the specific interaction between the 5'-terminal capped structure of mRNA and its binding protein.
D002352:Carrier Proteins / Q000235:genetics*; D006147:Guanine / Q000031:analogs & derivatives*; D009682:Magnetic Resonance Spectroscopy; D008957:Models, Genetic; D008958:Models, Molecular; D009690:Nucleic Acid Conformation; D011487:Protein Conformation; D012315:RNA Caps / Q000235:genetics*; D012333:RNA, Messenger / Q000235:genetics*; D016601:RNA-Binding Proteins; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D014364:Tryptophan; D014961:X-Ray Diffraction
D002352:Carrier Proteins; D012315:RNA Caps; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D006147:Guanine; C008450:7-methylguanine; D014364:Tryptophan