In vitro metabolism of cadaverine in the pregnant rat.
The in vitro metabolism of 14C-cadaverine by diamine oxidase was investigated in various tissues of pregnant and non-pregnant rats. The metabolites formed were: delta 1-piperideine, delta-aminovaleric acid, carbon dioxide and some unidentified compound(s). In most of the tissues investigated delta 1-piperideine was the predominant metabolite, but considerable amounts of delta-aminovaleric acid and the unidentified compound(s) were also formed. The oxidative products of cadaverine might be of importance in various physiological and pathophysiological connections associated with elevated diamine oxidase levels.
D006631:Amine Oxidase (Copper-Containing) / Q000032:analysis; D000596:Amino Acids / Q000378:metabolism; D021542:Amino Acids, Neutral; D000818:Animals; D002103:Cadaverine / Q000378:metabolism*; D003959:Diamines / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D011919:Rats, Inbred Strains
D000596:Amino Acids; D021542:Amino Acids, Neutral; D003959:Diamines; C013809:5-aminovaleric acid; D006631:Amine Oxidase (Copper-Containing); D002103:Cadaverine