Physiological model for the pharmacokinetics of 2,3,7,8-tetrachlorodibenzofuran in several species.
A flow-limited physiological model was developed to describe the time course of 2,3,7,8-tetrachlorodibenzofuran (TCDF) in the blood and tissues of rats, mice, and monkeys. The liver showed the greatest tendency to concentrate the material with tissue-to-blood distribution coefficients ranging from 30 in the monkey to 130 in the mouse. TCDF was also concentrated in the fat with tissue-to-blood distribution coefficients between 25 and 40 in all species. TCDF was eliminated by metabolism followed by excretion primarily to the feces. Urinary excretion was a minor route of elimination in all species. Metabolism was modeled as a linear process occurring in the liver. Intrinsic metabolic clearances ranged from 0.45 ml/min/kg in the monkey to 2.8 ml/min/kg in one species of mice. Fecal excretion of TCDF-derived radioactivity can be simulated with a series of well-mixed compartments which receive input of metabolites in the bile.
D000818:Animals; D001572:Benzofurans / Q000378:metabolism*; D004785:Environmental Pollutants / Q000378:metabolism*; D000882:Haplorhini; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008657:Metabolic Clearance Rate; D051379:Mice; D008815:Mice, Inbred Strains; D008954:Models, Biological; D051381:Rats; D013045:Species Specificity
D001572:Benzofurans; D004785:Environmental Pollutants; C014211:2,3,7,8-tetrachlorodibenzofuran