Nitroglycerin prolongs the bleeding time in healthy males.
Bleeding time was prolonged when measured 6 minutes after the administration of 0.5 mg nitroglycerin (NTG) sublingually in 15 men aged 25-40 years. The prolongation was not caused by a general inhibition of platelet aggregation. 4 g acetylsalicylic acid inhibited the effect of NTG on the bleeding time with a time course similar to the vessel wall cyclooxygenase. This may indicate that the effect of NTG is mediated by prostacyclin.
D000328:Adult; D001241:Aspirin / Q000008:administration & dosage; D001760:Bleeding Time; D003864:Depression, Chemical; D011464:Epoprostenol / Q000097:blood; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000009:adverse effects*; D010974:Platelet Aggregation / Q000187:drug effects*
D011464:Epoprostenol; D005996:Nitroglycerin; D001241:Aspirin