Unrelatedness of factor VIII-derived non-A/non-B hepatitis and hepatitis B virus.
A DNA hybridization assay was used to detect hepatitis B virus (HBV)-specific DNA sequences in extracted sera obtained from chimpanzees infected with HBV, hepatitis A virus (HAV), and a factor VIII-derived non-A/non-B (NANB) agent. The results did not reveal any HBV-DNA homology with sera obtained from animals infected with HAV or factor VIII-derived NANB. Sera obtained from two HBV-infected chimpanzees demonstrated that HBV-specific DNA could be detected during the acute phase of the disease. In addition, an HBV-specific DNA-dependent DNA polymerase assay did not demonstrate any statistically significant activity in 12 of 12 NANB acute-phase specimens or in 6 of 6 NANB chronic-phase specimens. These results suggest that the factor VIII-derived NANB agent is unrelated to HBV.
D000818:Animals; D001483:Base Sequence; D004279:DNA, Viral; D006515:Hepatitis B virus / Q000235:genetics*; D006526:Hepatitis C / Q000382:microbiology*; D006525:Hepatitis, Viral, Human / Q000382:microbiology*; D006801:Humans; D009693:Nucleic Acid Hybridization; D002679:Pan troglodytes
D004279:DNA, Viral