Arachidonic acid infusion in rabbits. Renal pathologic alterations.
Arachidonic acid infusion in rabbits is highly lethal, death occurring in greater than 90% of animals and most within 1 to 2 minutes. This effect may be inhibited by prior administration of vitamin E. Pathologic examination of renal tissue from animals killed in this manner demonstrated immunoglobulin and fibrin deposition in the glomeruli and interstitium of the kidney. No pathologic alterations were detected by light microscopy. Electromicroscopy revealed some endothelial cell swelling with no evidence of electron dense deposits, indicating the absence of immune complexes. Pathologic examination of the kidneys suggest the deposition of immunoglobulin in a non complexed form.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000008:administration & dosage / Q000494:pharmacology*; D003176:Complement C3 / Q000032:analysis; D004336:Drug Antagonism; D005337:Fibrin / Q000032:analysis; D005455:Fluorescent Antibody Technique; D007136:Immunoglobulins / Q000032:analysis; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects / Q000276:immunology / Q000473:pathology*; D008297:Male; D011817:Rabbits; D014810:Vitamin E / Q000494:pharmacology
D001095:Arachidonic Acids; D003176:Complement C3; D007136:Immunoglobulins; D014810:Vitamin E; D016718:Arachidonic Acid; D005337:Fibrin