Inhibition of ascorbate-induced and NADPH-dependent lipid peroxidation in hepatic nuclei by aflatoxin B1.
Aflatoxin B1 (AFB1) causes inhibition of ascorbate-induced and NADPH-dependent lipid peroxidation in hepatic nuclei, Fe2+-stimulated oxidation of linoleic acid is also inhibited by AFB1. The inhibition of lipid peroxidation by AFB1 is independent of its metabolism in nuclei and probably due to the anti-oxidant property of AFB1.
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000494:pharmacology*; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D009249:NADP / Q000378:metabolism*
D000348:Aflatoxins; D008054:Lipid Peroxides; D008315:Malondialdehyde; D009249:NADP; D016604:Aflatoxin B1; D001205:Ascorbic Acid