[Thymic hormones. Neuroendocrine interactions and clinical use in congenital and acquired immune deficiencies].
The epithelial cells of the thymus synthesize at least 30 different polypeptides: the thymic hormones. The structure of 4 of them is well known. They are named thymosin alpha 1, thymopoietin, thymulin and thymic humoral factor. Biological functions and secretion regulation of thymic hormones are described as well as the interactions between brain, thymus and endocrine glands. Blood levels and clinical usefulness of thymic hormones are reviewed in different congenital or acquired immunodeficient states and in autoimmune diseases.
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy; D001327:Autoimmune Diseases / Q000188:drug therapy; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000151:congenital / Q000188:drug therapy*; D010446:Peptide Fragments; D000077596:Thymalfasin; D013935:Thymic Factor, Circulating; D016305:Thymopentin; D013946:Thymopoietins; D013947:Thymosin / Q000031:analogs & derivatives; D013949:Thymus Extracts; D013951:Thymus Hormones / Q000378:metabolism / Q000502:physiology / Q000627:therapeutic use; D000099201:Thymosin beta(4)
D010446:Peptide Fragments; D000077596:Thymalfasin; D013935:Thymic Factor, Circulating; D016305:Thymopentin; D013946:Thymopoietins; D013947:Thymosin; D013949:Thymus Extracts; D013951:Thymus Hormones; D000099201:Thymosin beta(4); C033782:thymosin fraction 5; C031407:thymostimulin; C014859:thymic humoral factor
Les hormones thymiques. Interactions neuroendocriniennes et utilité clinique dans les déficits immunitaires congénitaux et acquis.