[Simulation of the effects of radiation injury of DNA and genetic hazards of radionuclide decay. Dehydration of purine nucleotides during decay of an incorporated tritium].
The dehydrogenation of purine nucleotides in position 8 is not a severe lethal injury. In addition, the dehydrogenation in the eight position of adenine is not an effective mutagenic event. The dehydrogenation in the eight position of guanine is a mutagenic damage. As to the induction of point mutations, 3H is not more hazardous than external gamma-radiation delivered in equivalent doses.
D004271:DNA, Fungal / Q000235:genetics / Q000378:metabolism* / Q000528:radiation effects; D005720:Gamma Rays; D005800:Genes, Fungal; D009154:Mutation; D011685:Purine Nucleotides / Q000378:metabolism* / Q000528:radiation effects; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism / Q000528:radiation effects*; D014316:Tritium / Q000378:metabolism*
D004271:DNA, Fungal; D011685:Purine Nucleotides; D014316:Tritium
Modelirovanie éffektov radiatsionnykh povrezhdeniĭ DNK i geneticheskaia opasnost' raspadov radionuklidov. Degidrirovanie purinovykh nukleotidov pri raspade inkorporirovannogo tritiia.