HLA-B15 association with erythema multiforme.
Erythema multiforme (EM) is a cutaneous reaction pattern which follows numerous infections, drugs, neoplastic and inflammatory disorders in some individuals. We undertook a prospective study of thirty-eight HLA specificities of the -A, -B, and -C series in 16 Caucasian patients with EM and in 140 local Caucasian controls. Seven of 16 patients (44%) with EM and 5 of 9 patients (55%) with EM following herpes simplex infections possessed the HLA-B15 antigen, compared to 7% of local controls and 11.6% of the 1980 WHO Workshop Caucasian controls. Both associations were highly significant (p = 0.0125 and p = 0.02) when corrected for 38 HLA antigens. This is the first reported HLA association for erythema multiforme, a disease which may be a host-specific immune response to various antigens, determined in part by genes linked to HLA-B15.
D004892:Erythema Multiforme / Q000235:genetics / Q000276:immunology*; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000276:immunology*; D015235:HLA-B Antigens; D059910:HLA-B15 Antigen; D006801:Humans
D006680:HLA Antigens; D015235:HLA-B Antigens; D059910:HLA-B15 Antigen