Leukotriene C release by macrophages.
Leukotriene C (LTC) and its metabolites leukotriene D and leukotriene E collectively make up the biological activity known as slow-reacting substance of anaphylaxis. Murine macrophages are potent sources of LTC (5(S)-hydroxy-6(R)-gamma-glutamylcysteinylglycyl-7,9-trans-11,14-cis-eicosatetr aenoic acid). Peritoneal and pulmonary tissue macrophages synthesize LTC and other arachidonic acid (20:4) metabolites in response to inflammatory stimuli such as unopsonized zymosan and IgG immune complexes. Peritoneal macrophages, in addition, release 20:4 when challenged with IgE immune complexes. These results suggest that macrophages may be a major source of leukotrienes in acute inflammation and also in immediate-type hypersensitivity reactions.
D000818:Animals; D000936:Antigen-Antibody Complex; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001202:Ascitic Fluid / Q000166:cytology; D007073:Immunoglobulin E / Q000276:immunology; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D011650:Pulmonary Alveoli / Q000166:cytology; D013189:SRS-A / Q000096:biosynthesis / Q000502:physiology*
D000936:Antigen-Antibody Complex; D001095:Arachidonic Acids; D013189:SRS-A; D016718:Arachidonic Acid; D007073:Immunoglobulin E