Ethanol as an inducer of UDP-glucuronyltransferase: a comparison with phenobarbital and 3-methylcholanthrene induction in rabbit hepatic microsomes.
In this report we have examined the ability of ethanol to induce UDP-glucuronyltransferase activity in male rabbits using p-nitrophenol as substrate. The rabbit was found to be an excellent species for studies of ethanol induction since almost 3-fold increases in activity were observed relative to controls. Ethanol induction of p-nitrophenol UDP-glucuronyltransferase activity was even greater than induction by 3-methylcholanthrene, the prototypic inducer of this type of activity. Thus, the rabbit shows promise for studies of UDP-glucuronyltransferase isozymes that are induced by chronic ethanol consumption.
D000818:Animals; D004790:Enzyme Induction; D000431:Ethanol / Q000494:pharmacology*; D014453:Glucuronosyltransferase / Q000096:biosynthesis*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D010634:Phenobarbital / Q000494:pharmacology; D011817:Rabbits
D000431:Ethanol; D008748:Methylcholanthrene; D014453:Glucuronosyltransferase; D010634:Phenobarbital