Animal models used in prediction of antidepressant effects in man.
The discovery of bupropion's potential antidepressant activity resulted from studies of its behavioral effects in a number of animal models of depression. These animal models and data pertaining to their selectivity for other standard antidepressant drugs are reviewed.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001522:Behavior, Animal / Q000187:drug effects*; D016642:Bupropion; D003866:Depressive Disorder / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004357:Drug Synergism; D006380:Helplessness, Learned; D006801:Humans; D007980:Levodopa / Q000494:pharmacology; D051379:Mice; D008954:Models, Biological; D009043:Motor Activity / Q000187:drug effects; D011427:Propiophenones / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors; D013747:Tetrabenazine / Q000037:antagonists & inhibitors
D000928:Antidepressive Agents; D011427:Propiophenones; D016642:Bupropion; D007980:Levodopa; D012110:Reserpine; D013747:Tetrabenazine