Non-chemokinetic neutrophil attractants derived from arachidonic acid.
Gradients of 15-hydroxy-5,8,11,13-eicosatetraenoic acid (15-HETE) and 15-hydroperoxy-5,8,11,13-eicosatetraenoic acid (15-HPETE) were significantly and equally chemotactic for human neutrophils at 15-75 microM. However, neither eicosanoid stimulated random migration when presented isotropically to cells, indicating a total lack of chemokinetic activity. These unique non-chemokinetic chemoattractants may be useful tools for dissecting the chemokinetic phase of neutrophil activation from the chemotactic phase.
D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000502:physiology*; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte; D006801:Humans; D006893:Hydroxyeicosatetraenoic Acids; D015289:Leukotrienes; D008054:Lipid Peroxides / Q000502:physiology*
D001095:Arachidonic Acids; D006893:Hydroxyeicosatetraenoic Acids; D015289:Leukotrienes; D008054:Lipid Peroxides; D016718:Arachidonic Acid; C025086:15-hydroperoxy-5,8,11,13-eicosatetraenoic acid; C025984:15-hydroxy-5,8,11,13-eicosatetraenoic acid