Ethanol, a Leydig cell toxin: evidence obtained in vivo and in vitro.
The available evidence which suggests that ethanol is a Leydig cell toxin is presented. Both in vivo and in vitro data are reviewed. The minor differences obtained in vitro as compared to those obtained in vivo are discussed. As a result of information obtained during the last decade, there can be little doubt that ethanol and possibly acetaldehyde are clinically important environmental Leydig cell toxins.
D000428:Alcohol Drinking; D000437:Alcoholism / Q000150:complications; D000818:Animals; D004958:Estradiol / Q000097:blood; D000431:Ethanol / Q000633:toxicity*; D005298:Fertility / Q000187:drug effects*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007248:Infertility, Male / Q000097:blood; D007985:Leydig Cells / Q000187:drug effects*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D051381:Rats; D013737:Testis / Q000187:drug effects; D013739:Testosterone / Q000097:blood
D000431:Ethanol; D013739:Testosterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone