A behavioral examination of convulsant benzodiazepine and GABA antagonist, Ro 5-3663, and benzodiazepine-receptor antagonist Ro 15-1788.
The potential "anxiogenic" effects of convulsant benzodiazepine and GABA-antagonist, Ro 5-3663 and specific antagonist of benzodiazepine receptors, Ro 15-1788 were compared in the Geller-Seifter conflict paradigm. Chlordiazepoxide (CDP) (5 mg/kg) was used as a "positive" control. Both Ro 5-3663 (1 mg/kg) and Ro 15-1788 (10 mg/kg) antagonized the anticonflict effect of CDP. However, while Ro 15-1788 had a modest anticonflict potency. Ro 5-3663 had an anxiogenic effect in its own right.
D000818:Animals; D001569:Benzodiazepines / Q000037:antagonists & inhibitors; D001570:Benzodiazepinones / Q000494:pharmacology*; D002707:Chlordiazepoxide / Q000494:pharmacology; D003220:Conflict, Psychological; D003292:Convulsants / Q000494:pharmacology*; D004347:Drug Interactions; D005442:Flumazenil; D008297:Male; D011678:Punishment; D051381:Rats; D012201:Reward
D001570:Benzodiazepinones; D003292:Convulsants; D001569:Benzodiazepines; D005442:Flumazenil; D002707:Chlordiazepoxide; C022193:Ro 5-3663