The assessment of hypothalamic pituitary maturation during puberty with a combined clomiphene citrate/GnRH test in boys.
The diagnosis of idiopathic delayed pubertal development in boys is difficult. A single GnRH test does not give information concerning hypothalamic maturity. After one week clomiphene citrate administration the LH reaction pattern is enhanced in subjects with maturing and depressed in subjects with immature hypothalamic-pituitary function.
D000293:Adolescent; D000328:Adult; D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000254:growth & development*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011628:Puberty, Delayed / Q000175:diagnosis*; D013739:Testosterone / Q000097:blood
D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone