Neurogenic modification of the vulnerability of the blood-brain barrier during acute hypertension in conscious rats.
To study the possible influence of sympathetic adrenergic tone on the blood-brain barrier function during acute hypertension in conscious unrestrained rats with indwelling catheters in the aorta and a jugular vein the blood pressure was increase by noradrenaline, 6-hydroxydopamine (6-OHDA) or baclofen. One or 60 min later the rats were sacrificed and the extravasation of 125I labelled albumin determined in the brain. After i.v. injection of noradrenaline the baroreceptor reflex will decrease the sympathetic tone whereas the blood pressure increased induced by the other two drugs is accompanied by an increased sympathetic activity. One minute after a corresponding rise in blood pressure the albumin content in the brain was considerably lower in rats given 6-OHDA than in those given noradrenaline. 60 min after the injection of 6-OHDA or baclofen the extravasation in the brain did not differ despite a considerably more rapid increase in pressure after 6-OHDA. Pretreatment with clonidine increased the blood-brain barrier dysfunction in rats given 6-OHDA but not in those given baclofen, probably because the slower rise in pressure facilitates myogenic autoregulation. It is concluded that neurogenic influences on vessel tone can modify the response of the blood-brain barrier during acute hypertension in conscious rats.
D000320:Adrenergic Fibers / Q000187:drug effects*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002245:Carbon Dioxide / Q000097:blood; D003000:Clonidine / Q000494:pharmacology*; D006892:Hydroxydopamines / Q000494:pharmacology*; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D016627:Oxidopamine; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D051381:Rats; D011919:Rats, Inbred Strains; D012711:Serum Albumin, Radio-Iodinated / Q000134:cerebrospinal fluid*
D006892:Hydroxydopamines; D012711:Serum Albumin, Radio-Iodinated; D002245:Carbon Dioxide; D016627:Oxidopamine; D001418:Baclofen; D003000:Clonidine; D010100:Oxygen; D009638:Norepinephrine