Abolishment of the Ranvier node excitability under quasi-total deuteration and rhythmic stimulation.
The isolated nerve fibre, when quasi-totally deuterated, loses its excitability after about 15' of rhythmic stimulation at frequencies of 150-200 Hz. It is only on internal rehydration that excitability is recovered at high frequencies of stimulation. An excitation-energy coupling is suggested to exist, which appears to be more obvious at high frequencies of stimulation and strongly affected by the proton-deuteron exchange in the intracellular medium.
D000200:Action Potentials; D000818:Animals; D001001:Anura; D003903:Deuterium / Q000009:adverse effects*; D004558:Electric Stimulation; D011901:Ranvier's Nodes / Q000187:drug effects / Q000502:physiology*
D003903:Deuterium