Intracellular concentration and transmembrane fluxes of sodium and potassium in erythrocytes of white normal male subjects with and without a family history of hypertension.
Compared with white normal males without a family history of hypertension (n = 43), red blood cells of white normal males with such a family history (n = 17) had a higher (P less than 0.01) intracellular sodium concentration (8.07 +/- 0.30 versus 7.33 +/- 0.17 mmol/l cells). This could be at least partly due to their lower (P less than 0.001) frusemide-sensitive sodium efflux rate (250 +/- 19 versus 424 +/- 23 mumol/l cells/h). Also their ouabain-resistant 86Rb-uptake (0.81 +/- 0.06 versus 0.97 +/- 0.03 mumol/l cells/h) was lower (P less than 0.05). Potassium concentration in the red blood cells was similar in both groups.
D000450:Aldosterone / Q000502:physiology; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000032:analysis*; D005665:Furosemide / Q000494:pharmacology; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007610:Kallikreins / Q000502:physiology; D008297:Male; D011188:Potassium / Q000097:blood*; D011868:Radioisotopes; D012083:Renin / Q000502:physiology; D012413:Rubidium / Q000378:metabolism; D012964:Sodium / Q000097:blood*
D011868:Radioisotopes; D000450:Aldosterone; D005665:Furosemide; D012964:Sodium; D007610:Kallikreins; D012083:Renin; D012413:Rubidium; D011188:Potassium