Effect of estradiol on the oxalate metabolism in vitamin B6-deficient male rats.
Estradiol-implanted (EB) and sham-operated (SB) male rats (100-120 g Fody wt) were kept on a vitamin B6-deficient diet for 1 month along (Formula: see text) with their respective estradiol pair-fed (EPF) and sham-operated pair-fed (SPF) controls. Pyridoxine-deficient animals had higher kidney weights and increased activities of liver glycolic acid oxidase (GAO) and glycolic acid dehydrogenase (GAD) as compared to their pair-fed control animals. Kidney weights, GAO, and GAD levels in these animals are negatively correlated with erythrocyte alanine transaminase (EALT) levels, indicating that pyridoxine status regulates these two major enzymes of oxalate biosynthesis. Estradiol-treated animals showed a lower reduction in EALT levels after feeding them a pyridoxine-deficient diet for 1 month as compared to untreated animals. Estradiol administration decreased GAO levels in both normal and pyridoxine-deficient animals.
D000410:Alanine Transaminase / Q000097:blood; D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000818:Animals; D001835:Body Weight; D004343:Drug Implants; D004958:Estradiol / Q000494:pharmacology*; D008099:Liver / Q000201:enzymology; D008297:Male; D009929:Organ Size; D010070:Oxalates / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D026681:Vitamin B 6 Deficiency / Q000378:metabolism*
D004343:Drug Implants; D010070:Oxalates; D004958:Estradiol; D000429:Alcohol Oxidoreductases; C020819:glycolic acid dehydrogenase; C020821:glycollate oxidase; D000410:Alanine Transaminase