Long-acting contraceptive agents: analysis and purification of steroid esters.
More than 200 samples of esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) and levonorgestrel (13 beta-ethyl-17 alpha-ethynyl-17 beta-hydroxygon-4-en-3 -one) have been analysed by a combination of techniques, including high performance liquid chromatography (HPLC). Compounds having a purity below the required limit (99.5%) were purified, mainly by preparative HPLC, prior to formulation and biological evaluation as long-acting progestogens.
D002851:Chromatography, High Pressure Liquid; D003276:Contraceptives, Oral / Q000138:chemical synthesis*; D003277:Contraceptives, Oral, Combined / Q000138:chemical synthesis*; D003692:Delayed-Action Preparations; D004952:Esters; D007202:Indicators and Reagents; D016912:Levonorgestrel; D009640:Norethindrone / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D009644:Norgestrel / Q000138:chemical synthesis*; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D003692:Delayed-Action Preparations; D004952:Esters; D007202:Indicators and Reagents; D009644:Norgestrel; D016912:Levonorgestrel; D009640:Norethindrone