[Prospects for using platinum coordination compounds possessing antitumor activity].
The review presents a complete analysis of studies on experimental and clinical application of platinum complexes with special reference to cis-dichlorodiamminoplatinum, both separately and in combination with other chemotherapeutic preparations. Platinum complexes show their highest antiblastic activity in treatment of ovarian, testicular, lung tumours and those located in the head and neck regions as well as of the bladder cancer and tumours of the other localizations resistant to the action of alkylating agents and other preparations. The clinical material is systematized so that it is possible on the basis of the analysis performed to choose an optimum regime for treating different tumours by platinum complexes.
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002945:Cisplatin / Q000009:adverse effects / Q000627:therapeutic use*; D004351:Drug Resistance; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010051:Ovarian Neoplasms / Q000188:drug therapy; D013736:Testicular Neoplasms / Q000188:drug therapy; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000556:secondary
D002945:Cisplatin
Perspektivy primeneniia koordinatsionnykh soedineniĭ platiny, obladaiushchikh protivoopukholevoĭ aktivnost'iu.