[Bone marrow transplantation in panmyelopathies and leukemias with special regard to gnotobiotic measures].
Bone-marrow transplantations were performed in 71 patients, 11 with panmyelopathy, 17 with recurrence of acute leukaemia, 25 with acute leukaemia and remission, 18 with chronic myeloid leukaemia. The transplantation was allogenic in 67, autologous in 2, isologous in 2. Eight patients each survived in the panmyelopathy and chronic myeloid leukaemia groups. In the group of patients with acute leukaemia only one patient of those in a recurrence survived the transplantation for several years, but after 6 years there was another recurrence. Of the 20 patients with acute myeloid leukaemia who received the transplantation during their first remission, 11 are still alive. Retransplantation because of the recurrence was employed in one case each of acute and chronic myeloid leukaemia. Main cause of death was interstitial pneumonia with an overall risk of 23%. Only 5% of patients developed severe acute graft-versus-host reaction, grades III-IV. The low incidence of this reaction is possibly due to the strict gnotobiotic measures which in most of the patients led to decontamination of the intestinal tract.
D000293:Adolescent; D000328:Adult; D001855:Bone Marrow Diseases / Q000628:therapy*; D016026:Bone Marrow Transplantation; D002648:Child; D002678:Chimera; D003666:Decontamination; D005856:Germ-Free Life; D006086:Graft vs Host Disease / Q000401:mortality; D006801:Humans; D007938:Leukemia / Q000628:therapy*; D007945:Leukemia, Lymphoid / Q000401:mortality; D015470:Leukemia, Myeloid, Acute / Q000401:mortality; D010357:Patient Isolators; D011658:Pulmonary Fibrosis / Q000401:mortality
Knochenmarktransplantationen bei Panmyelopathie und Leukämien unter besonderer Berücksichtigung gnotobiotischer Massnahmen.