Cross-reactivity between Mycobacterium tuberculosis H37Rv and various actinomycetes and related organisms.
One hundred and forty-one strains of Actinomycetales and related organisms were investigated by immunodiffusion for the presence of antigens which cross-react with the antigens of M. tuberculosis H37Rv. The test strains comprised 86 different species names and 20 different genus names; they were mainly environmental organisms isolated from soil, plants, animals and such like. More than 90% of these strains were shown to have one or more antigens in common with the tubercle bacillus, and 77% had two or more antigens in common with this organism. Certain strains, of Nocardia and Rhodococcus, demonstrated abundant cross-reactivity with the tubercle bacilli, sharing up to 5 and 6 precipitinogens respectively.
D000192:Actinomycetales / Q000276:immunology*; D000942:Antigens, Bacterial / Q000032:analysis*; D003429:Cross Reactions; D005779:Immunodiffusion; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011234:Precipitins / Q000032:analysis
D000942:Antigens, Bacterial; D011234:Precipitins