[Sensitivity of Candida strains to polyenic antibiotics in the treatment of oral candidiasis].
Sensitivity of 146 clinical strains of Candida albicans to nystatin, levorin and amphoglucamine was studied on solid media with the replica method. The strains were isolated from 79 patients with candidiasis of the oral mucosa. It was found that sensitivity of the fungi to the polyenic antibiotics was different which should be considered in treatment of candidiasis. On the basis of the mean MICs for the clinical strains and their distribution by the MICs it was shown that the activity level of levorin and amphoglucamine was higher than that of nystatin. During the treatment resistance of the Candida strains to the polyenic antibiotics increased and cross resistance developed which required application of other treatment means.
D000666:Amphotericin B / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000935:Antifungal Agents / Q000627:therapeutic use*; D002174:Candicidin / Q000627:therapeutic use*; D002176:Candida albicans / Q000187:drug effects*; D002180:Candidiasis, Oral / Q000188:drug therapy* / Q000382:microbiology; D004352:Drug Resistance, Microbial; D006801:Humans; D009761:Nystatin / Q000627:therapeutic use*
D000935:Antifungal Agents; D009761:Nystatin; D002174:Candicidin; C023999:amphoglucamine; D000666:Amphotericin B
Izuchenie chuvstvitel'nosti gribov roda Candida k polienovym antibiotikam v protsesse lecheniia kandidoza slizistoĭ polosti rta.