[Fundamental and clinical studies of T-1982 (cefbuperazone) in the field of obstetrics and gynecology].
T-1982 (cefbuperazone), a new cephamycin antibiotic, was fundamentally and clinically studied. The following results were obtained. Serum and internal genital tissue levels of T-1982 were measured following intravenous injection or intravenous drip infusion of 1 g. High serum levels of more than 10 micrograms/ml and tissue levels of more than 5 micrograms/g were maintained for 3 hours after intravenous administration. Favourable transfer of T-1982 into the pelvic dead space exudate was observed. The exudate level attained its peak at 2 hours and was 14.6 micrograms/ml on average even at 8 hours after intravenous infusion. With its MIC values, T-1982 was considered to be bactericidal against many Gram-negative bacteria except Pseudomonas sp. A total of 4 cases comprising 2 with pyometra, 1 with pelveoperitonitis and 1 with endometritis complicated with pelveoperitonitis was treated with T-1982 at a dose of 1-2 g twice daily by intravenous drip infusion. The clinical response was excellent in 1 case and good in 2 cases. A case with pyometra due to S. faecalis did not respond to the therapy. Side effects and abnormal laboratory findings due to the drug were not noted.
D000328:Adult; D000368:Aged; D002513:Cephamycins / Q000378:metabolism* / Q000494:pharmacology; D004716:Endometritis / Q000188:drug therapy; D013293:Enterococcus faecalis / Q000187:drug effects; D005260:Female; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008875:Middle Aged; D010538:Peritonitis / Q000188:drug therapy; D014599:Uterus / Q000032:analysis
D002513:Cephamycins; C035978:cefbuperazone