[Doppler ultrasound studies of the extracranial cerebral vessels in migraine patients after ergotamine tartrate administration].
Doppler ultrasound investigations were done in 20 patients with migraine during the symptom-free interval after oral administration of 2 mg and 6 mg ergotamine tartrate. The observed changes of end-diastolic flow velocity as a measure of peripheral total resistance permit simultaneous assessment of the vasoconstrictor effect of ergotamine in the perfusion area of the internal and external carotid arteries. A dosage of 2 mg led to an exclusive increase of resistance in the external carotid artery area without significant changes in the internal carotid area. A maximal therapeutic dosage of 6 mg ergotamine tartrate did not lead to a significant increase of the vasoconstrictor effect in the external carotid circulation. In addition, a barely registrable increase of resistance in the internal carotid area could now be observed.
D000328:Adult; D000368:Aged; D002342:Carotid Artery, External / Q000187:drug effects*; D002343:Carotid Artery, Internal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004878:Ergotamine; D004879:Ergotamines / Q000008:administration & dosage*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D013997:Time Factors; D014463:Ultrasonography
D004879:Ergotamines; D004878:Ergotamine
Dopplersonographische Untersuchungen der extrakraniellen Hirngefässe bei Migräne-Patienten nach Gabe von Ergotamintartrat.