Mycobacteria arabinolipids as potential endotoxins: their activity on mitochondrial oxidative phosphorylation.
Two natural arabinolipids from the cell wall of Mycobacterium tuberculosis (5-mycoloyl-D-arabinose and 5-mycoloyldiarabinoside) and two synthetic arabinolipids (5-mycoloyl-L-arabinose and 5-mycoloyl(2'-hydroxyethyl)L-arabinoside) were tested on rat liver mitochondria. 5-Mycoloyl D- and L-rabinose had the same low activity, while 5-mycoloyldiarabinoside efficiently lowered the ADP/O ratio, inhibited active respiration and increased controlled respiration. The synthetic 5-mycoloyl(2'-hydroxyethyl)arabinoside had an intermediate efficiency. Due to their activity on mitochondria, the arabinolipids of the mycobacterial cell wall can be considered as potential endotoxins.
D000818:Animals; D001089:Arabinose / Q000031:analogs & derivatives* / Q000494:pharmacology; D002473:Cell Wall; D004731:Endotoxins; D006017:Glycolipids / Q000494:pharmacology*; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000187:drug effects*; D009169:Mycobacterium tuberculosis / Q000502:physiology*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D051381:Rats
D004731:Endotoxins; D006017:Glycolipids; D001089:Arabinose