Depression of resistance against Salmonella infection in sarcoma 180-bearing mice and its restoration by Salmonella mini-cells.
The reduction of resistance against Salmonella infection was resulted from the reduction of macrophage activities in Sarcoma 180-bearing mice. Mean survival day of S180-bearing mice was markedly reduced to 1.4 +/- 0.5 days after the challenge with 1 X 10(8) of Salmonella typhimurium LT2 cells in contrast with 6.8 +/- 1.9 days of normal mice. Eighty percent of S180-bearing mice died within 14 days after the challenge with 1 X 10(6) of LT2 cells, whereas all of normal mice survived more than 30 days after the challenge with 3 X 10(6) or less of LT2 cells. Chemotactic and O2- producing activities of macrophages collected from S180-bearing mice which were treated with Salmonella mini-cells restored to normal level. Bactericidal activity of macrophages was also restored by the mini-cell treatment. The restoration of the resistance to Salmonella was accompanied with increases of macrophage activities.
D000818:Animals; D002633:Chemotaxis; D005260:Female; D007113:Immunity, Innate; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010101:Oxygen Consumption; D012481:Salmonella Infections, Animal / Q000276:immunology*; D012486:Salmonella typhimurium; D012510:Sarcoma 180 / Q000276:immunology*