HLA and the rubella-specific immune response following vaccination.
A group of 88 seronegative 11-year-old Dutch girls was selected to be tested for human leukocyte antigens (HLA) and for both the in vivo and in vitro immune response to rubella virus, 6 and 12 weeks after rubella vaccination. Although a slight influence of HLA-associated factors on the antibody levels, as measured by the enzyme-linked immunosorbent assay could not be excluded, no evidence for HLA-associated control of the rubella-specific immune response following vaccination was obtained. From these data it is concluded that HLA-associated factors cannot be expected to hamper the effectiveness of large-scale rubella vaccination procedures.
D000914:Antibodies, Viral / Q000096:biosynthesis*; D002648:Child; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D012411:Rubella Vaccine / Q000276:immunology*; D012412:Rubella virus / Q000276:immunology*; D014611:Vaccination
D000914:Antibodies, Viral; D006680:HLA Antigens; D012411:Rubella Vaccine; D003208:Concanavalin A