The biochemical basis of myocardial failure.
Cardiac failure can begin with metabolic disturbances within the myocardial cell--in the mitochondria, contractile proteins, or other cellular organelles. It also can result from faulty adrenergic regulation of contraction. New technology is making it possible to synthesize the contributing factors into a clinical model that will greatly enhance our understanding of these mechanisms.
D006328:Cardiac Catheterization; D009202:Cardiomyopathies / Q000378:metabolism*; D003327:Coronary Disease / Q000378:metabolism; D006801:Humans; D008929:Mitochondria, Heart / Q000378:metabolism; D010085:Oxidative Phosphorylation; D012508:Sarcolemma / Q000378:metabolism; D012519:Sarcoplasmic Reticulum / Q000378:metabolism