Electric shock titration in squirrel monkeys following administration of nantradol, levonantradol, or N-methyl levonantradol.
The effects of some cannabinoid-related analgesics were examined in squirrel monkeys responding under a schedule of shock titration. Nantradol (0.1-0.3 mg/kg), levonantradol (0.03-0.1 mg/kg), or N-methyl levonantradol (0.01-0.03 mg/kg) increased the level at which shock was maintained, but did not change rates of responding. Nantradol effects were not blocked by naloxone (0.3-3.0 mg/kg), but they were attenuated following daily administration of nantradol.
D000700:Analgesics / Q000008:administration & dosage; D000818:Animals; D002427:Cebidae / Q000502:physiology*; D004597:Electroshock; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D010617:Phenanthridines / Q000008:administration & dosage*; D012453:Saimiri / Q000502:physiology*
D000700:Analgesics; D010617:Phenanthridines; D009270:Naloxone; C032495:N-methylnantradol; C025490:nantradol