Prophylaxis of adverse reactions to foods. A double-blind study of oral sodium cromoglycate for the prophylaxis of adverse reactions to foods and additives.
Twenty-four adult patients with adverse reactions to foods and food additives took part in a double-blind crossover study to compare the efficacy of oral sodium cromoglycate, 1600 mg daily, with placebo. Duration of treatment was eight weeks. There were statistically significant differences (p less than 0.01) in favor of active treatment as assessed by patients' diary card scores during the last week of treatment. Few side effects were observed. Oral sodium cromoglycate appears to be both effective and well tolerated in the treatment of food allergies, particularly when used in conjunction with a maintenance elimination diet.
D000284:Administration, Oral; D000328:Adult; D001241:Aspirin / Q000009:adverse effects; D002986:Clinical Trials as Topic; D004205:Cromolyn Sodium / Q000008:administration & dosage*; D004311:Double-Blind Method; D005260:Female; D005503:Food Additives / Q000009:adverse effects*; D005512:Food Hypersensitivity / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013645:Tartrazine / Q000009:adverse effects
D005503:Food Additives; D013645:Tartrazine; D004205:Cromolyn Sodium; D001241:Aspirin