Antigen-specific and concanavalin A-induced lymphocyte blastogenesis responses during the course of Plasmodium berghei infection in rats.
Antigen specific and concanavalin A (Con A)-induced lymphocyte blastogenesis responses were monitored in the spleens of rats infected with Plasmodium berghei. Con A responses were depressed only at the time of peak parasitaemia. The antigen specific blastogenesis response was either not in evidence, or at a low level during the periods of patent or subpatent infection (up to 8 weeks after infection). Higher levels of blastogenesis were seen from 8 to 12 weeks after infection, which correlates with clearance of subpatent infection. Fractionation of immune spleen cell suspensions on nylon wool columns indicated that purified T cells did not respond to parasite antigen.
D000818:Animals; D000941:Antigens / Q000276:immunology; D002469:Cell Separation; D003208:Concanavalin A / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D008288:Malaria / Q000276:immunology*; D008297:Male; D010962:Plasmodium berghei / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D000941:Antigens; D003208:Concanavalin A