[Proliferation kinetics of various tissues following administration of different carcinogens of different kinds of organotropism].
Inhibition of cell division of targets and nontarget tissues is one of the acute actions of chemical carcinogens. A single gastric dose of N-methyl-N-nitro-N'-nitrosoguanidine (MNNG) causes a mitotic suppression in the forestomach, in the jejunal crypts and in the esophagus. 2-acetylamino-fluorene (AAF) causes the same suppression in the esophagus and the liver. In contrast, the mitotic activity is increased in liver and adrenal cortex by MNNG and in the adrenal cortex by AAF. Both the inhibiting and mitogenic action depend on the circadian phase of treatment.
D015073:2-Acetylaminofluorene / Q000494:pharmacology*; D000302:Adrenal Cortex / Q000187:drug effects; D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D004064:Digestive System / Q000187:drug effects; D004947:Esophagus / Q000187:drug effects; D007583:Jejunum / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D008938:Mitosis / Q000187:drug effects; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000187:drug effects
D008769:Methylnitronitrosoguanidine; D015073:2-Acetylaminofluorene
Zur Proliferationskinetik verschiedener Gewebe nach Cancerogenen unterschiedlicher Organotropie.