[Correlation of the sister chromatid exchange level with chromosome aberrations induced by chemical mutagens in vivo].
The data on the dose dependencies of the induction of sister chromatid exchanges (SCE) and chromosomal aberrations during exposure of mouse bone marrow cells in vivo to 5 alkylating substances are provided. The efficacy of SCE induction was found to be higher than that of chromosomal aberrations. It was established that SCE induced by chemical mutagens in vivo and in vitro are more sensitive and stable tests than chromosomal aberrations.
D000477:Alkylating Agents; D000818:Animals; D000970:Antineoplastic Agents; D001388:Aziridines / Q000494:pharmacology; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D003434:Crossing Over, Genetic; D004305:Dose-Response Relationship, Drug; D008357:Mannomustine / Q000494:pharmacology; D051379:Mice; D008808:Mice, Inbred CBA; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D009153:Mutagens; D012854:Sister Chromatid Exchange; D013852:Thiotepa / Q000494:pharmacology
D000477:Alkylating Agents; D000970:Antineoplastic Agents; D001388:Aziridines; D008937:Mitomycins; D009153:Mutagens; D016685:Mitomycin; D013852:Thiotepa; C026480:inproquone; D008357:Mannomustine; C007526:dipin
Korreliatsiia urovnia sestricheskikh khromatidnykh obmenov i khromosomnykh aberratsiĭ, indutsirovannykh khimicheskimi mutagenami in vivo.