Ethanol and tetrahydroisoquinoline alkaloids do not produce narcotic discriminative stimulus effects.
Male Sprague-Dawley rats were trained in a two lever food-reinforced procedure to discriminate between the effects of saline and the synthetic narcotic analgesic fentanyl (0.04 mg/kg). After acquisition of this discrimination, generalization tests with morphine, ethanol and some tetrahydroisoquinoline alkaloids were conducted. The rats dose-dependently generalized the effect of morphine but did not generalize the effects of either ethanol, tetrahydropapaveroline, salsolinol or 3-carboxysalsolinol to the fentanyl discriminative stimulus. Thus, these date do not support a biochemical link between ethanol and opiates.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D004193:Discrimination Learning / Q000187:drug effects; D004192:Discrimination, Psychological / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D007276:Injections, Intraventricular; D007546:Isoquinolines / Q000494:pharmacology*; D008297:Male; D009294:Narcotics / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000470:Alkaloids; D007546:Isoquinolines; D009294:Narcotics; D000431:Ethanol