[Urinary excretion of N-acetyl-beta-D-glucosaminidase in patients with urological disease: with special reference to hydronephrosis].
Activity of urinary N-acetyl-beta-D-glucosaminidase (NAG) has been studied in patients with urological diseases. In most patients with benign prostatic hyperplasia, prostate cancer and bladder cancer, activity of urinary NAG was elevated (92.9%), especially in cases of indwelling catheterization or poor visualization of IVU. Urinary NAGs were also elevated for all patients with renal stones, ureter stones, uretero-cutaneous stomy or a single kidney. In hydronephrosis or hydronephrosis with hydroureter patients, urinary NAG level was low pre-operatively, but increased post-operatively. Urinary beta 2-microglobulin (BMG) showed a similar tendency in patients with hydronephrosis or hydronephrosis with hydroureter. Electronmicroscopic observations of the kidney in such patients revealed many primary and secondary lysosomes.
D000118:Acetylglucosaminidase / Q000652:urine*; D000328:Adult; D002675:Child, Preschool; D006596:Hexosaminidases / Q000652:urine*; D006801:Humans; D006869:Hydronephrosis / Q000175:diagnosis* / Q000201:enzymology / Q000473:pathology; D007668:Kidney / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D001613:beta 2-Microglobulin / Q000652:urine
D001613:beta 2-Microglobulin; D006596:Hexosaminidases; D000118:Acetylglucosaminidase