The inhibition of class C beta-lactamases by boronic acids.
Aromatic boronic acids are reversible inhibitors of the recently classified class C beta-lactamases. The boronic acids studied include ortho-, meta- and para-methyl-, -hydroxymethyl- and -formyl-phenylboronic acid. The beta-lactamases were chromosomally-encoded enzymes, one from Pseudomonas aeruginosa, and the other specified by the ampC gene of Escherichia coli. The inhibition may be correlated with our finding that these beta-lactamases are serine enzymes, i.e. their function entails the hydroxy group of a serine residue acting as a nucleophile.
D001665:Binding Sites; D001897:Boronic Acids / Q000138:chemical synthesis / Q000494:pharmacology*; D004926:Escherichia coli / Q000201:enzymology; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D011550:Pseudomonas aeruginosa / Q000201:enzymology; D013329:Structure-Activity Relationship; D065093:beta-Lactamase Inhibitors
D001897:Boronic Acids; D007527:Isoenzymes; D065093:beta-Lactamase Inhibitors