HLA and B-lymphocyte alloantigens in Gila River Indians.
HLA-A, B, C, DR, and MB and MT B-lymphocyte alloantigens were tested in 249 Pima and Papago Indians from Arizona. Frequencies of A and B locus antigens in Pimas were similar to published values for other North American Indians, as well as previous reports from Pimas. Cw3 was the most frequent C locus antigen found and DR5 was the most frequent DR antigen. Another B-cell specificity, DuB31, behaved as a DR allele and had a phenotype frequency of .717. This study is the first report of MB and MT frequencies in a North American Indian population, and the pattern of association with some DR antigens appears to be different from that observed in Europeans. MT3 had a phenotype frequency of .583, but was not associated with DR4, 7, 9, which suggests an undefined DR allele associated with MT3.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001130:Arizona; D001402:B-Lymphocytes / Q000276:immunology*; D002648:Child; D005787:Gene Frequency; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006650:Histocompatibility Testing; D006801:Humans; D007198:Indians, North American; D008875:Middle Aged; D010641:Phenotype
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II