Adrenocortical response to acute and chronic ethanol administration in rats.
Acute ethanol administration (2 g/kg IP) induced a significant rise in serum corticosterone levels which seemed to be related to blood ethanol concentration. Chronic ethanol administration, in the form of a liquid diet for 16 or 30 days, did not alter the levels of serum corticosterone. Chronic treatment of rats with a liquid diet containing ethanol resulted in the development of tolerance.
D000302:Adrenal Cortex / Q000187:drug effects*; D000818:Animals; D003345:Corticosterone / Q000097:blood; D004032:Diet; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000431:Ethanol; D003345:Corticosterone