The influence of prazosin on E. coli lipopolysaccharide-induced fever and noradrenaline hyperthermia.
We investigated the effect of prazosin on experimental fever induced by E. coli lipopolysaccharide (LPS) and on noradrenaline hyperthermia in the rabbit. LPS and prazosin were administered iv and ivc, noradrenaline was administered only iv. Prazosin inhibited both LPS fever and noradrenaline hyperthermia in a dose-dependent manner. The results indicate the participation of alpha-adrenoceptor in the pyrogen fever and noradrenaline hyperthermia.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D004926:Escherichia coli; D005260:Female; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008070:Lipopolysaccharides / Q000037:antagonists & inhibitors*; D008297:Male; D009638:Norepinephrine / Q000037:antagonists & inhibitors*; D011224:Prazosin / Q000494:pharmacology*; D011799:Quinazolines / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors
D008070:Lipopolysaccharides; D011799:Quinazolines; D009638:Norepinephrine; D011224:Prazosin