[Somatocrinin induces growth hormone release in a case of growth hormone deficiency of hypothalamic origin in a child].
Somatocrinin (hp-GRF-44), a growth hormone releasing factor, stimulates acute pituitary response in a 11 years and 4 months old boy, with growth hormone deficiency. The capability of the anterior pituitary to secrete growth hormone in response to an IV injection of somatocrinin (120 micrograms 4 micrograms/kg) was documented, therefore proving the hypothalamic origin of the deficit which had been suspected because of association of diabetes insipidus and hyperprolactinemia.
D002648:Child; D006130:Growth Disorders / Q000097:blood / Q000188:drug therapy*; D013006:Growth Hormone / Q000097:blood / Q000172:deficiency*; D013007:Growth Hormone-Releasing Hormone / Q000008:administration & dosage*; D006801:Humans; D007027:Hypothalamic Diseases / Q000097:blood / Q000188:drug therapy*; D007263:Infusions, Parenteral; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage*; D013997:Time Factors
D010446:Peptide Fragments; D013006:Growth Hormone; D013007:Growth Hormone-Releasing Hormone
La somatocrinine provoque la libération de somathormone dans un cas de déficit en somathormone d'origine hypothalamique chez l'enfant.