Interaction of adenosine 5'-triphosphate with metal ions X-ray structure of ternary complexes containing Mg(II), Ca(II), Mn(II), Co(II), ATP and 2,2'-dipyridylamine.
The X-ray structures of the isomorphous Mg2+, Ca2+, Mn2+ and Co2+ complexes of ATP have been determined. The metal ions are wrapped in hexa-coordination by the alpha, beta and gamma phosphate groups of two ATP molecules thus blocking the interaction of the metal ions with the adenine base. A second metal ion which is fully hydrated, M(H2O)2+(6), is engaged in a strong hydrogen bond with the gamma phosphate group of ATP and suggests a possible step in facilitating the cleavage between the beta and gamma phosphates in phosphoryl transfer reactions.
D015082:2,2'-Dipyridyl / Q000031:analogs & derivatives; D000255:Adenosine Triphosphate; D002118:Calcium; D003035:Cobalt; D006860:Hydrogen Bonding; D008274:Magnesium; D008345:Manganese; D008670:Metals; D008968:Molecular Conformation; D015394:Molecular Structure; D009942:Organometallic Compounds; D010710:Phosphates; D014961:X-Ray Diffraction
D008670:Metals; D009942:Organometallic Compounds; D010710:Phosphates; D003035:Cobalt; D008345:Manganese; D015082:2,2'-Dipyridyl; D000255:Adenosine Triphosphate; D008274:Magnesium; D002118:Calcium; C048062:2,2'-dipyridylamine