Effect of alkaline glutaraldehyde on hepatitis B virus antigens.
The potential of alkaline 2% glutaraldehyde solutions, with and without surface active agents, to alter the antigenicity of hepatitis B virus (HBV) was analyzed and compared to the antigenic alternation capacities of 0.525% sodium hypochlorite and 2.02% formaldehyde solutions. After treatment of a hepatitis B surface antigen-positive plasma at room temperature for 10 min, there was a 51-67% reduction in surface antigen level and a 90-94% decrease in hepatitis B core antigenicity. Glutaraldehyde is proposed as an alternative to the more noxious hypochlorite and formaldehyde solutions for disinfection of HBV-contaminated articles.
D000447:Aldehydes / Q000494:pharmacology*; D000468:Alkalies; D002478:Cells, Cultured; D004202:Disinfectants; D005976:Glutaral / Q000494:pharmacology*; D006512:Hepatitis B Core Antigens / Q000032:analysis*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006515:Hepatitis B virus / Q000187:drug effects* / Q000276:immunology; D006801:Humans
D000447:Aldehydes; D000468:Alkalies; D004202:Disinfectants; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D005976:Glutaral