The possible roles of prostaglandins and related compounds in endometrial bleeding. A mini-review.
This mini-review summarizes some aspects of hemostatic defects, with particular reference to endometrial bleeding, both the normal menstruation and some bleeding disorders of the uterus. Two cell types are of particularly great interest in the hemostatic mechanism, viz. the platelet and the vascular endothelial cell. We will therefore start with a brief survey of the roles of platelets and vascular endothelium in hemostasis, and the underlying biochemical events will be discussed, particularly the participation of the arachidonate metabolites: the prostaglandins, the thromboxanes and the leukotrienes. This section is then followed by a brief description of some histological findings in the menstruating endometrium; the normal as well as the pathologically bleeding tissue. The possible roles of arachidonate metabolites in these events will be discussed. Several clinical studies have been published, in which various attempts have been made to treat excessive endometrial bleeding with inhibitors of prostaglandin biosynthesis. The findings in these studies are described. The relevance of this approach and its possible effects on other areas of arachidonic acid metabolism will be discussed. Finally, some studies will be summarized in which various attempts have been made to quantitate and endometrial prostaglandins in different physiological and pathological conditions.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001241:Aspirin / Q000494:pharmacology; D001792:Blood Platelets / Q000502:physiology; D016861:Cyclooxygenase Inhibitors; D004717:Endometrium / Q000098:blood supply / Q000503:physiopathology*; D004727:Endothelium / Q000098:blood supply; D011464:Epoprostenol / Q000502:physiology; D005260:Female; D005337:Fibrin / Q000502:physiology; D006487:Hemostasis; D006801:Humans; D007434:Intrauterine Devices; D008598:Menstruation / Q000187:drug effects; D011449:Prostaglandin Endoperoxides / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology*; D013928:Thromboxane A2 / Q000502:physiology; D014592:Uterine Hemorrhage / Q000188:drug therapy / Q000503:physiopathology*; D014599:Uterus / Q000378:metabolism
D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D011449:Prostaglandin Endoperoxides; D011453:Prostaglandins; D016718:Arachidonic Acid; D013928:Thromboxane A2; D005337:Fibrin; D011464:Epoprostenol; D001241:Aspirin