Antitumor effect of 5-fluorouracil in combination with some additives which stimulate the formation of antineoplastic 5-fluorouracil nucleotides.
Both ribose 1-phosphate and deoxyribose 1-phosphate, which were effective in increasing the formation of antineoplastic fluoronucleotides and fluoro-RNA from 5-fluorouracil (5-FU) in the intact cells of Ehrlich mouse ascites tumor, potentiated the antitumor effect of 5-FU. Ethylenediaminetetraacetate, which stimulates the formation of only fluororibonucleotides from 5-FU in intact Ehrlich tumor cells, was ineffective in the potentiation of 5-FU antitumor activity. The relationship between the increased metabolite formation from 5-FU and the antitumor effect of 5-FU is discussed.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D002478:Cells, Cultured; D004359:Drug Therapy, Combination; D004492:Edetic Acid / Q000494:pharmacology; D005472:Fluorouracil / Q000008:administration & dosage* / Q000378:metabolism; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D010428:Pentosephosphates / Q000008:administration & dosage*; D012267:Ribosemonophosphates / Q000008:administration & dosage*
D010428:Pentosephosphates; D012267:Ribosemonophosphates; C031302:2-deoxyribose 1-phosphate; D004492:Edetic Acid; D005472:Fluorouracil