[Quantitative histochemical studies of islands of Langerhans in the (Psammomys obesus) in the development of diabetes mellitus. II. Surface measurement of the islands].
Measurement of the islet-area are pointed out in 30 sand rats. The animals are divided in 3 groups: 8 sand rats are the reference group, 11 animals are the IGT-group (impaired glucose tolerance), and the diabetic group consists also of 11 sand rats. The islet-area is in the IGT-group increased in 173.2%. It is concluded that the islet-volume is also increased. The diabetic group is characterized by the maximal increase of the islet area (431.4%). Hyperplasia of Langerhans' islets is detectable histologically. The sand rat is a biological model of the human non-insulin-dependent diabetes mellitus (NIDDM).
D000818:Animals; D003411:Arvicolinae; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D003924:Diabetes Mellitus, Type 2 / Q000473:pathology; D006965:Hyperplasia; D007515:Islets of Langerhans / Q000473:pathology*
Quantitativ-histochemische Untersuchungen an Langerhansschen Inseln von Sandratten (Psammomys obesus) während der Ausbildung eines Diabetes mellitus. II. Flächenmessung der Inseln.