Diurnal variation of DNA synthesis in premalignant hamster cheek pouch.
The right cheek pouch of hamsters was painted twice a week with DMBA for 4 and 7 weeks in different groups. It was found that there were diurnal rhythms and non-random distributions of DNA synthesis and mitotic events in DMBA-treated hamster-cheek-pouch epithelium. The degree of these changes was markedly greater than the changes in non-treated control pouches. The finding of cluster formation was described as 'symphokinesis', the non-random grouping of basal cells with synchronous DNA cycles during tissue growth.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002610:Cheek; D002940:Circadian Rhythm; D006224:Cricetinae; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D007399:Interphase; D008297:Male; D008647:Mesocricetus; D009061:Mouth Mucosa / Q000378:metabolism / Q000473:pathology*; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*; D011230:Precancerous Conditions / Q000139:chemically induced / Q000378:metabolism / Q000473:pathology*
D004273:DNA, Neoplasm; D015127:9,10-Dimethyl-1,2-benzanthracene