Effects of surfactants on the GI absorption of beta-lactam antibiotics in rats.
The effects of various nonionic and ionic surfactants and two bile salts (sodium cholate and sodium taurocholate) on the GI absorption of beta-lactam antibiotics were investigated using the in situ rat GI perfusion technique. Addition of 10 mM polyoxyethylene-23-lauryl ether in the perfusion solution reduced the absorption of propicillin by the stomach and markedly increased the absorption of propicillin and cefazolin by the small intestine. Ester-type nonionic surfactants and bile salts exerted no significant influence on the intestinal absorption of these antibiotics.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D002437:Cefazolin / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D010404:Penicillin V / Q000031:analogs & derivatives / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013501:Surface-Active Agents / Q000494:pharmacology*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D013501:Surface-Active Agents; C100135:propicillin; D002437:Cefazolin; D010404:Penicillin V