Influence of the culture conditions of Brucella abortus on its antitumor properties.
A heat-inactivated rough mutant of B. abortus increased resistance to a transplantable lymphoma when cultured on solid agar (ag) but not when cultured on a fluid medium (fl). The ag organisms were smaller, more toxic and induced more interferon 2 h after injection than fl. They also contained a phospholipid (cardiolipin) absent from fl preparations.
D000818:Animals; D002003:Brucella abortus / Q000254:growth & development / Q000276:immunology*; D003470:Culture Media; D005260:Female; D007167:Immunotherapy; D007369:Interferon Inducers; D007370:Interferon Type I / Q000502:physiology; D008223:Lymphoma / Q000628:therapy*; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000628:therapy
D003470:Culture Media; D007369:Interferon Inducers; D007370:Interferon Type I