Digitoxin intoxication with severe thrombocytopenia: reversal by digoxin-specific antibodies.
As a result of overdosage a 77-year-old patient with heart disease developed digitoxin intoxication, associated with arrhythmias, extracardiac symptoms of intoxication and severe thrombocytopenia. Treatment with digoxin-specific antibody fragments relieved the signs and symptoms of intoxication within a few hours. The rise in platelet count from the pretreatment value of 26 000/mm3 to 47 000 within 12 h and to over 60 000/mm3 within 16 h of starting the antibody infusion may also be attributed to the treatment with antibodies. Such a rapid recovery from digitoxin-induced thrombocytopenia has not hitherto been described. Digoxin-specific antibodies, obtained by immunization of sheep with a digoxin-albumin conjugate, were used to treat intoxication with digitoxin, since cross-reaction had been demonstrated in vitro and in animal experiments. The present paper briefly discusses the mode of action and the general problems relating to the antibody therapy of digitalis poisoning.
D000368:Aged; D000818:Animals; D004074:Digitoxin / Q000008:administration & dosage / Q000506:poisoning*; D004077:Digoxin / Q000276:immunology*; D005500:Follow-Up Studies; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000008:administration & dosage*; D007167:Immunotherapy; D007263:Infusions, Parenteral; D008297:Male; D010976:Platelet Count; D012646:Self Administration / Q000009:adverse effects; D012756:Sheep; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000628:therapy
D007140:Immunoglobulin Fab Fragments; D004077:Digoxin; D004074:Digitoxin