Naloxone suppresses the vasodepressor action of captopril in the anaesthetized dog.
The effects of intracisternal injection of captopril (0.3 mg/kg) on the systolic pressor response elicited by afferent stimulation of the vagus were investigated in the anaesthetized dog. The captopril-induced decrease in the systolic pressor response to vagal stimulation was reversed by a subsequent injection of naloxone (0.1 mg/kg i.v.). These results suggest the involvement of central opioid mechanisms in the hypotensive properties of captopril.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000037:antagonists & inhibitors*; D004285:Dogs; D009270:Naloxone / Q000494:pharmacology*; D011392:Proline / Q000031:analogs & derivatives*; D012018:Reflex / Q000187:drug effects*; D014630:Vagus Nerve / Q000187:drug effects
D009270:Naloxone; D011392:Proline; D002216:Captopril