Plasma membrane nadh dehydrogenase and Ca2+-dependent potassium transport in erythrocytes of several animal species.
Ca2+-dependent K+ transport and plasma membrane NADH dehydrogenase activities have been studied in several 'high-K+' (human, rabbit and guinea pig) and 'low-K+' (dog, cat and sheep) erythrocytes. All the species except sheep showed Ca2+-dependent K+ transport. NADH-ferricyanide reductase was detected in all the species and showed positive correlation with the flavin contents of the membranes. NADH-cytochrome c reductase was very low or absent in dog, sheep and guinea pig membranes. No correlation was found between NADH dehydrogenase and Ca2+-dependent K+ channel activities in the species studied. Nor were any of the above activities correlated with (Na+ + K+)-ATPase activity.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001693:Biological Transport, Active / Q000187:drug effects; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology*; D002415:Cats; D003579:Cytochrome Reductases / Q000097:blood*; D004285:Dogs; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006168:Guinea Pigs; D006801:Humans; D007700:Kinetics; D008773:Methylphenazonium Methosulfate / Q000494:pharmacology; D009245:NADH Dehydrogenase / Q000097:blood*; D011188:Potassium / Q000097:blood*; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D012756:Sheep; D013045:Species Specificity
D008773:Methylphenazonium Methosulfate; D000001:Calcimycin; D011433:Propranolol; D003579:Cytochrome Reductases; D009245:NADH Dehydrogenase; D001205:Ascorbic Acid; D011188:Potassium; D002118:Calcium