New compounds for neutron capture therapy (NCT) and their significance.
The significant advantage to be gained from combining the improved penetration of a scandium filtered beam with the reduced dose to normal tissues makes the development of 3rd generation compounds for NCT of considerable importance.
D000818:Animals; D001894:Borohydrides; D001896:Boron Compounds / Q000138:chemical synthesis / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D006224:Cricetinae; D003857:Deoxyuridine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000627:therapeutic use; D005998:Glycine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000627:therapeutic use; D006801:Humans; D051379:Mice; D009369:Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D009502:Neutrons; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D013438:Sulfhydryl Compounds / Q000627:therapeutic use
D001894:Borohydrides; D001896:Boron Compounds; D011838:Radiation-Sensitizing Agents; D013438:Sulfhydryl Compounds; C014651:mercaptoundecahydrododecaborate; C044286:dihydroxyboryldeoxyuridine; C044285:2-boronoglycine; D005998:Glycine; D003857:Deoxyuridine