[Increase in blood uric acid induced by indomethacin in hens or chickens].
Indomethacin (2.5 mg/kg) causes a rapid increase in plasma urate concentrations and at 5 mg/kg I.M. may cause death by deposition of urates in the viscera (visceral gout). This increase is probably a consequence of decreased renal tubular urate secretion. The sensitivity to indomethacin varies either according to the strain of Bird or the physiological status: Hens appear more sensitive during egg formation.
D000818:Animals; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D005260:Female; D006073:Gout / Q000139:chemically induced; D007213:Indomethacin / Q000009:adverse effects / Q000494:pharmacology*; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid; D007213:Indomethacin
Augmentation de l'uricémie induite par l'indométhacine chez la poule ou le poulet.