Optimum ventilation levels for maintenance of normal arterial blood pO2, pC02, and pH in the pithed rat preparation.
Cardiovascular status in artificially respired whole animal preparations is dependent, among other factors, upon the maintenance of normal blood gas and acid-base equilibria. A method is described for respiring the pithed rat preparation with oxygen-enriched air. Using this system, ventilation-body weight relations have been defined for maintenance of normal blood pO2, pC02, and pH values in this commonly employed preparation.
D000818:Animals; D001158:Arteries / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood*; D006863:Hydrogen-Ion Concentration; D008297:Male; D010100:Oxygen / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D012121:Respiration, Artificial; D013116:Spinal Cord / Q000502:physiology; D013318:Stroke Volume
D002245:Carbon Dioxide; D010100:Oxygen