[Effect promoting the rejection of an allograft of skin in rabbits treated with a high dose of amethopterin].
Present results show that the preventive inoculation of a single high dose of ametopterin (Methotrexate: MTX) may induce in rabbits the accelerated rejection of a skin allograft. This finding is sustained by an enhancing or adjuvant action of the agent on the mechanism of cell-mediated immunity.
D000818:Animals; D005260:Female; D006084:Graft Rejection / Q000187:drug effects*; D008297:Male; D008727:Methotrexate / Q000494:pharmacology*; D011817:Rabbits; D016038:Skin Transplantation; D013997:Time Factors
D008727:Methotrexate
Sull'effetto promuovente la reiezione di un alloinnesto di cute nel coniglio trattato con una dose elevata di ametopterina.