A role for luteinizing hormone and follicle-stimulating hormone in the etiology of simple goiters in the pediatric population.
In light of the progressive, pubertal increases in serum gonadotropin (FSH, LH) levels coinciding with the peak incidence of simple goiters; the common alpha subunits associated with the gonadotropins, TSH and hCG; the ability of LH and hCG to bind to thyroid TSH receptors and affect thyroid function; and, the probable interactions between thyroid hormones and gonadotropins, a role for gonadotropins in the etiology of simple goiters merits consideration.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005640:Follicle Stimulating Hormone / Q000502:physiology*; D006042:Goiter / Q000209:etiology*; D006801:Humans; D007986:Luteinizing Hormone / Q000502:physiology*
D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone