[Alcohol dehydrogenase in the blood of healthy people and in patients with chronic alcoholism].
Activity of alcohol dehydrogenase (ADH) was estimated using highly sensitive spectrophotometric procedure with p-nitrose dimethylaniline as a substrate in blood serum of control healthy persons without a history of alcohol abuse and of the patients with chronic alcoholism. The ADH activity in the control group was about 0.55 +/- 0.04 microM/min/L and in the patients it was 2.5-5-fold higher. A direct correlation was found between the ADH activity and duration of alcohol abuse. In the patients with alcohol abstention syndrome the activity of ADH was 4.2-fold higher as compared with controls. During the remission, from 2 months up to 5 years, the enzymatic activity decreased, but was still distinctly higher than the control values.
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000429:Alcohol Oxidoreductases / Q000097:blood*; D000437:Alcoholism / Q000097:blood / Q000201:enzymology*; D000431:Ethanol / Q000097:blood; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009243:NAD / Q000097:blood; D013997:Time Factors
D009243:NAD; D000431:Ethanol; D000429:Alcohol Oxidoreductases; D000410:Alanine Transaminase
Alkogol'degidrogenaza syvorotki krovi zdorovykh liudeĭ i bol'nykh khronicheskim alkogolizmom.