A population survey of pancreatic islet cell antibodies and antithyroid antibodies.
In a survey of one Japanese population, we detected pancreatic islet cell antibodies (ICA), antithyroid antibodies (ATA) and antinuclear antibodies (ANA). The prevalence of ICA was 6 out of 1125 cases, or 0.5%. ATA and ANA were detected in 8.9% and 1%, respectively. There were no cases of either type I or type II diabetes in subjects with ICA. But there was one case who had ATA and another with ANA. Serum samples from this population had been obtained once a year from 1979 and one case with neither ATA nor ANA was found positive for ICA in 1980. Identical tests for ICA were performed on 80 childhood diabetics as were carried out on type I diabetics. Pancreatic isles cell surface antibodies (ICsA), ATA and ANA were studied simultaneously. The prevalence of ICA in 80 cases was 36.3% and that of ICsA was 13.8%. 4 cases had both ICA and ICsA. The prevalence of ATA was 11.2% and that of ANA was 16.3%.
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D003920:Diabetes Mellitus / Q000276:immunology; D005260:Female; D006801:Humans; D007515:Islets of Langerhans / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000276:immunology*
D000974:Antibodies, Antinuclear; D001323:Autoantibodies