[Level of 5-FU in tumor tissues of the patients with head and neck malignant tumors after oral administration of UFT].
Levels of futraful (FT-207), 5-FU and Uracil in blood and tissue were measured on 11 cases of oral malignant tumors after administration of UFT. 1) After administration of UFT, the highest level of 5-FU was detected in tumor tissue followed by the normal lymph node, metastatic lymph node, and normal tissue which showed the lowest level. 2) Levels of 5-FU in serum was lower than in tumor, and T/S ratio of levels of 5-FU was 9,190. 3) There were significant regressions in levels of 5-FU and Uracil in normal lymph node (p less than 0.02). Coefficient of correlation was 0.469. 4) Comparisons of levels of 5-FU after administration of UFT and futraful were 1.89 in tumor, 1.72 in normal tissue, 1.80 in metastatic lymph node and 1.55 in normal lymph node. Level of 5-FU after administration of UFT was higher than that of futraful. 5) Higher level of 5-FU after administration of UFT in tumor tissue and lymph node were maintained for a longer period.
D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols; D004338:Drug Combinations / Q000008:administration & dosage; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000032:analysis* / Q000097:blood; D006258:Head and Neck Neoplasms / Q000032:analysis* / Q000188:drug therapy; D006801:Humans; D008198:Lymph Nodes / Q000032:analysis; D005641:Tegafur / Q000008:administration & dosage* / Q000032:analysis; D014498:Uracil / Q000008:administration & dosage* / Q000032:analysis
D000970:Antineoplastic Agents; D004338:Drug Combinations; D005641:Tegafur; D014498:Uracil; D005472:Fluorouracil