[Blood group antigens may be the receptors for immunoallergic drug complexes reacting with erythrocytes].
19 antibodies specific for 11 different drugs were extensively tested in the presence of the drug against a panel of red cells including common and public minus phenotypes. High incidence blood group antigens were shown to be specific receptors for several drug-antibody complexes proving thereby that red blood cells play more than an "innocent bystander" role in drug induced immune hemolytic anemias.
D058186:Acute Kidney Injury / Q000276:immunology; D000743:Anemia, Hemolytic / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000032:analysis*; D001789:Blood Group Antigens / Q000276:immunology*; D004910:Erythrocyte Membrane / Q000276:immunology*; D006801:Humans; D010641:Phenotype; D011971:Receptors, Immunologic / Q000032:analysis*; D012293:Rifampin / Q000276:immunology
D000936:Antigen-Antibody Complex; D001789:Blood Group Antigens; D011971:Receptors, Immunologic; D012293:Rifampin
Les antigènes de groupes sanguins peuvent être les cibles des conflits immunoallergiques médicamenteux à affinité érythrocytaire.