[Iron-sulfur centers and free radicals of the electron transfer chains of mitochondria in chemical and hormonal carcinogenesis].
One of the possible reasons for peculiar features of the tumour cell energetics is discussed. Regular variations in the iron-sulphur protein content in the mitochondrial electron transport chains were shown in models of chemical and hormonal carcinogenesis. A decrease in the content of these proteins in the tumoural tissue is found at early stages of malignant growth against a background of higher concentration of free radicals. Irreversible nature of an iron-sulphur protein decrease was observed in the liver and adrenals of tumour-bearing animals both under development of hormonal genesis tumours and at various stages of chemical carcinogenesis. Coming from the results obtained it is suggested that disturbances in the state of iron-sulphur proteins affect the oxidation phosphorylation efficiency and that modification of compensatory mechanism results in the glycolysis activation, which is a characteristic feature of the tumour cell energetics.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic; D004579:Electron Transport; D005260:Female; D005609:Free Radicals; D006728:Hormones / Q000633:toxicity*; D007506:Iron-Sulfur Proteins / Q000378:metabolism*; D007700:Kinetics; D008667:Metalloproteins / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats
D002273:Carcinogens; D005609:Free Radicals; D006728:Hormones; D007506:Iron-Sulfur Proteins; D008667:Metalloproteins; D015127:9,10-Dimethyl-1,2-benzanthracene
Zhelezosernye tsentry i svobodnye radikaly élektrontransportnoĭ tsepi mitokhondriĭ pri khimicheskom i gormonal'nom kantserogeneze.