Intranasal administration of nitroglycerine attenuates the pressor response to laryngoscopy and intubation of the trachea.
The intranasal administration of nitroglycerine (NTG) was undertaken in 35 adult female patients 1 min before the induction of anaesthesia. A control group consisting of 32 patients did not receive NTG. Systolic arterial pressure (SAP) and heart rate (HR) were recorded before the induction of anaesthesia and at 0, 3, and 5 min after tracheal intubation. SAP did not increase significantly in the NTG group immediately after intubation, while significant decreases in SAP were observed at 3 and 5 min (P less than 0.005 and P less than 0.001 respectively). SAP did increase significantly in the control group. HR was increased in both groups immediately after intubation (P less than 0.001 and P less than 0.001 respectively). NTG administered intranasally is a safe, simple and effective method to attenuate the hypertensive response to laryngoscopy and tracheal intubation.
D000281:Administration, Intranasal; D000328:Adult; D000768:Anesthesia, General; D001794:Blood Pressure / Q000187:drug effects*; D003864:Depression, Chemical; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007442:Intubation, Intratracheal; D007828:Laryngoscopy; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology*
D005996:Nitroglycerin