Analysis of human class II antigen alpha chain genes: a summary.
A cDNA clone corresponding to the HLA-DR alpha chain has been isolated following immunoprecipitation of polysomes with a monoclonal antibody against the denatured DR alpha chain. This cDNA clone has been used to isolate and solve the complete structure of the DR alpha chain gene and a cDNA clone corresponding to the DC alpha chain. The DR alpha and the DC alpha chains bear remarkable homology to each other and have one domain (alpha 2) which is a member of the immunoglobulin superfamily. The DC alpha chain gene has been demonstrated to be the homologue of the murine I-A alpha chain gene, and it has been localized on chromosome 6 using deletion mutants. A restriction enzyme polymorphism of the DC alpha chain gene has been detected in HLA-DR homozygous typing cells. This report is a summary of a presentation made at the HLA-DR meeting held in Marseille, France.
D004247:DNA / Q000235:genetics; D005796:Genes; D005802:Genes, MHC Class II; D006684:HLA-DR Antigens; D006801:Humans; D046911:Macromolecular Substances; D008285:Major Histocompatibility Complex; D008565:Membrane Proteins / Q000235:genetics; D011110:Polymorphism, Genetic; D012333:RNA, Messenger / Q000235:genetics
D006684:HLA-DR Antigens; D046911:Macromolecular Substances; D008565:Membrane Proteins; D012333:RNA, Messenger; D004247:DNA