[Non-secretory myeloma of heavy mu-chain type].
We report on a patient with a bone marrow plasmacell infiltration, since this case displays some outstanding clinical and laboratory features: the presence of massive splenomegaly and the absence of bone lesions; the cytoplasmic heavy chain type mu, without any light chain detectable by immunofluorescence (IF); the non secretory feature of this plasma cell proliferation. The position of such an entity within the spectrum of B-lymphoproliferative disorders, from mu heavy chain disease to non secretory IgM myeloma, is discussed.
D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000032:analysis*; D007148:Immunoglobulin mu-Chains / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood / Q000276:immunology*; D009194:Myeloma Proteins / Q000032:analysis*; D010950:Plasma Cells / Q000276:immunology / Q000648:ultrastructure
D007143:Immunoglobulin Heavy Chains; D007148:Immunoglobulin mu-Chains; D009194:Myeloma Proteins
Myélome non excrétant à chaîne lourde mu.