Glucocorticosteroids I: anti-inflammatory mechanisms.
Although progress in understanding how steroids work has accelerated in the past few years, several important factors have eluded definitive analysis. Broadly, the mechanisms affect leukocyte traffic and function: Glucocorticoids inhibit the availability of leukocytes to the inflammatory site, interfere with their function at the site, and thus suppress the normal inflammatory response.
D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005938:Glucocorticoids / Q000494:pharmacology* / Q000502:physiology; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects* / Q000201:enzymology; D008231:Lymphopenia / Q000139:chemically induced; D008262:Macrophage Activation / Q000187:drug effects; D009000:Monocytes / Q000187:drug effects; D009504:Neutrophils / Q000187:drug effects; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D004791:Enzyme Inhibitors; D005938:Glucocorticoids; D011448:Prostaglandin Antagonists