Hypotaurine transport in mouse brain synaptosomal preparations.
The transport of hypotaurine, the precursor of the probable neuromodulator taurine, was investigated using mouse brain synaptosomal preparations. Hypotaurine uptake was concentrative, energy- and sodium-dependent and strongly inhibited by GABA, L-DABA (L-2,4-diaminobutyric acid) and beta-alanine, suggesting interactions with GABA uptake systems. The uptake consisted of only one saturable transport component both in adult and in 6-day-old brain, being more efficient in the latter.
D000328:Adult; D000367:Age Factors; D000613:Aminobutyrates / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013574:Synaptosomes / Q000378:metabolism*; D013654:Taurine / Q000031:analogs & derivatives* / Q000378:metabolism; D015091:beta-Alanine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D000613:Aminobutyrates; D015091:beta-Alanine; D013654:Taurine; C005959:2,4-diaminobutyric acid; D005680:gamma-Aminobutyric Acid; C003949:hypotaurine