[Genetic differences in mice in the sensitivity to the immunodepressive action of alkylating agents].
The immunodepressant action of cyclophosphamide, thiophosphamide and sarcolysine was examined in experimental primary immune response in mice of different lines immunized with sheep red blood cells. DBA/2 and C3H/Sn mice were marked by the highest sensitivity to the immunodepressant action of the alkylating agents. BALB/c mice were relatively resistant to the immunodepressant action. Possible reasons for the interspecific differences found are discussed.
D000477:Alkylating Agents / Q000276:immunology*; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D003520:Cyclophosphamide / Q000276:immunology; D004351:Drug Resistance; D007108:Immune Tolerance / Q000187:drug effects*; D008558:Melphalan / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D013045:Species Specificity; D013852:Thiotepa / Q000276:immunology
D000477:Alkylating Agents; D003520:Cyclophosphamide; D013852:Thiotepa; D008558:Melphalan
Geneticheskie razlichiia u mysehĭ v chuvstvitel'nosti k immunodepressivnomu deĭstviiu alkiliruiushchikh agentov.