A double-blind randomized clinical study of the use of Hexabrix in pediatric angiocardiography.
A double-blind clinical study of 50 children undergoing cardiac catheterization was performed to evaluate Hexabrix and Renografin-76 in pediatric angiocardiography. The contrast agents were randomly assigned. There was no statistical difference in image quality between Hexabrix and Renografin-76 at similar iodine concentrations and no subjective difference in radio-opacity or overall angiographic quality. Little or no discomfort was experienced with Hexabrix whereas with Renografin-76, there was more pain. Hexabrix may be advantageous for cardiovascular diagnosis since motion artifact due to pain can adversely affect angiographic detail.
D000293:Adolescent; D000790:Angiocardiography; D006328:Cardiac Catheterization; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003287:Contrast Media; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007463:Iodobenzoates; D007485:Ioxaglic Acid; D011897:Random Allocation; D014283:Triiodobenzoic Acids
D003287:Contrast Media; D004338:Drug Combinations; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; C027278:urovision; D007485:Ioxaglic Acid