Strain difference in immune response of the rat to NRK cells infected with spleen focus-forming virus of the Friend leukaemia virus complex.
Five rat strains were studied for immune responsiveness to SFFV-NRK, a normal rat kidney cell line non-productively infected with spleen focus-forming virus (SFFV) of the Friend leukaemia virus (FLV) complex. Antisera from ACI, JAR, Fischer and SD strains precipitated SFFV-specific gene product, gp55, whereas those from LEW did not. In the cross of Fischer X LEW, immune responsiveness to gp55 was controlled by a single or a few dominant genes. The immune responsiveness was neither related to the susceptibility to FLV infection, nor to the amount of SFFV-related RNA in spleen cells. Unresponsiveness of LEW rats to gp55 was not absolute; when LEW rats were immunized with FLV preparations from infected mice or xenotropic virus-infected NRK cells, they produced antibody that could precipitate gp55.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis* / Q000235:genetics; D002460:Cell Line; D005622:Friend murine leukemia virus / Q000235:genetics / Q000276:immunology; D005799:Genes, Dominant; D005802:Genes, MHC Class II; D007942:Leukemia, Experimental / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology*; D012367:RNA, Viral / Q000235:genetics / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains / Q000276:immunology*; D013045:Species Specificity; D013154:Spleen / Q000276:immunology*; D014776:Virus Cultivation
D000914:Antibodies, Viral; D012367:RNA, Viral