Cardiovascular effects of antihypertensive drugs as affected by dietary polyunsaturates.
Polyunsaturate-rich vegetable oils (sunflower oil, linseed oil, primrose oil) augment the hypotensive effect of dihydralazine, clonidine and captopril in rats under different experimental conditions. Evidence has accumulated that these effects are mediated via changes in prostanoid formation and sympathetic activity.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002216:Captopril / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology; D004041:Dietary Fats / Q000494:pharmacology*; D004078:Dihydralazine / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000172:deficiency / Q000494:pharmacology*; D007668:Kidney / Q000032:analysis; D011453:Prostaglandins / Q000032:analysis; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains
D000959:Antihypertensive Agents; D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D011453:Prostaglandins; D002216:Captopril; D003000:Clonidine; D004078:Dihydralazine