Effects of 2% enflurane on intracranial pressure and cerebral perfusion pressure.
Ten patients with cerebral tumours were anaesthetized with thiopentone, 70% nitrous oxide in oxygen and fentanyl. Ventilation was controlled to give mean PaCO2 4.8 (range 3.6-6.7) kPa. Enflurane 2% was administered and ICP and MAP were recorded continuously for 10-15 min. The changes in ICP were not significant and ranged from -18.5 to 5.5 mm Hg. There were significant decreases in MAP (P less than 0.001) and CPP (P less than 0.001) during the administration of enflurane. In four patients the administration of enflurane had to be terminated prematurely because of a low CPP. Thus, enflurane has very little effect on ICP in patients with cerebral tumours and low concentrations of enflurane can safely be used during anaesthesia for intracranial operations, provided that the arterial pressure is monitored carefully.
D000769:Anesthesia, Inhalation; D001794:Blood Pressure / Q000187:drug effects; D001932:Brain Neoplasms / Q000503:physiopathology / Q000601:surgery; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003864:Depression, Chemical; D004737:Enflurane / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects*; D010313:Partial Pressure
D002245:Carbon Dioxide; D004737:Enflurane