Gamma interferon synthesis by human thymocytes and T lymphocytes inhibited by cyclosporin A.
Cyclosporin A depresses the synthesis of gamma interferon by human thymocytes and T lymphocytes in vitro. This observation is of potential clinical significance because the long-term treatment of transplant patients with cyclosporin A, a widely used immunosuppressive agent, can give rise to B-cell lymphoma resulting from Epstein-Barr virus activation.
D002455:Cell Division / Q000187:drug effects; D002675:Child, Preschool; D003524:Cyclosporins / Q000494:pharmacology*; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000096:biosynthesis*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D013950:Thymus Gland / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism
D003524:Cyclosporins; D007371:Interferon-gamma