[Beta-propiolactone as a sterilizing agent in the manufacture of intravenous immunoglobulin preparations].
It was demonstrated with phi X174, phi e and x phages that the beta-propiolactone step, which eliminated the anticomplementary activity of the intravenous immunoglobulin (IgG) preparation. Intraglobin, inactivates more than 10(6) viruses/ml. This means additional safety with respect to those viral diseases for which specific and sensitive diagnostic methods are not available at present.
D001435:Bacteriophages / Q000187:drug effects; D004339:Drug Compounding; D005079:Excipients; D007074:Immunoglobulin G / Q000031:analogs & derivatives*; D016756:Immunoglobulins, Intravenous; D007275:Injections, Intravenous; D007783:Lactones / Q000494:pharmacology*; D011420:Propiolactone / Q000494:pharmacology*; D013242:Sterilization
D005079:Excipients; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D007783:Lactones; D011420:Propiolactone
beta-Propiolacton als sterilisierendes Agens bei der Herstellung eines intravenösen Immunoglobulin-Präparates.