Delayed-type hypersensitivity reaction to H-Y antigen in mice. Effects of soluble antigen from Sertoli cells.
The delayed-type hypersensitivity (DTH) response to the H-Y antigen was investigated in female mice which had been pre-treated with soluble or insoluble H-Y antigen. The present results suggest that Sertoli cells, cultured in vitro, release a factor which, if highly soluble, induces tolerance to male spleen cells. Mice showing marked DTH produced high titre H-Y antibodies after further injections of spleen cells from syngeneic males.
D000818:Animals; D002478:Cells, Cultured; D005260:Female; D006182:H-Y Antigen / Q000276:immunology* / Q000302:isolation & purification; D006968:Hypersensitivity, Delayed / Q000209:etiology / Q000276:immunology*; D007108:Immune Tolerance; D007114:Immunization; D007518:Isoantibodies / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology; D012708:Sertoli Cells / Q000032:analysis / Q000276:immunology*; D013154:Spleen / Q000276:immunology / Q000637:transplantation
D006182:H-Y Antigen; D007518:Isoantibodies