Protective properties of peptidoglycan associated protein of Shigella flexneri.
Groups of CH3/Hej mice were immunized with peptidoglycan associated protein (PGP) from Shigella flexneri 3a administered in a single intraperitoneal injection (5 micrograms per mouse). After various periods post immunization the animals were challenged intraperitoneally with homologous bacteria. PGP proved to be strongly immunogenic. As early as one week after immunization all the animals survived challenge with 100 X LD100, and one third of the animals survived challenge with a dose of 500 X LD100. This high state of immunity maintained at almost unaltered intensity for 12 weeks after immunization (the end of the observations period).
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000276:immunology*; D007114:Immunization; D051379:Mice; D008809:Mice, Inbred C3H; D010457:Peptidoglycan / Q000276:immunology*; D012763:Shigella flexneri / Q000276:immunology*
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D010457:Peptidoglycan