Comprehensive study of haemostasis in chronic uraemia.
A comprehensive study of haemostasis has been performed in a homogeneous group of 25 adult patients with conservatively treated chronic uraemia. We have found prolonged bleeding time, impaired platelet adhesiveness and aggregation, and decreased platelet factor 3 activity, increased values of fibrinogen, of factor VIII activity and related antigen, and of combined levels of factors II, VII and X. Non-significantly abnormal concentrations of factor XIII and of plasminogen and significantly lower values of plasminogen activators and higher values of urokinase inhibitors and anti-plasmin have also been found. Fibrinogen degradation products were detected in the urine of some patients.
D000328:Adult; D001779:Blood Coagulation Factors / Q000032:analysis*; D002908:Chronic Disease; D005169:Factor VIII / Q000032:analysis; D005338:Fibrin Fibrinogen Degradation Products / Q000652:urine; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D006470:Hemorrhage; D006487:Hemostasis; D006801:Humans; D010958:Plasminogen / Q000378:metabolism; D010973:Platelet Adhesiveness; D010977:Platelet Factor 3 / Q000032:analysis; D014511:Uremia / Q000097:blood*; D014568:Urokinase-Type Plasminogen Activator / Q000037:antagonists & inhibitors
D001779:Blood Coagulation Factors; D005338:Fibrin Fibrinogen Degradation Products; D010977:Platelet Factor 3; D005169:Factor VIII; D005340:Fibrinogen; D010958:Plasminogen; D014568:Urokinase-Type Plasminogen Activator