Thyroxine deiodination during in vitro lipid peroxidation of rat liver inner membrane particles.
Thyroxine inhibitory action was observed during in vitro Fe2+ induced lipid peroxidation of rat liver mitochondrial inner membrane particles. In the course of lipid peroxidation thyroxine was degraded preferentially to reverse triiodothyronine. Inhibition of lipid peroxidation by EDTA abolished the formation of reverse triiodothyronine. Nonenzymic deiodination of thyroxine leading to reverse triiodothyronine production may be of a considerable importance in various pathological states accompanied by lipid peroxidation.
D000818:Animals; D002474:Cell-Free System; D004492:Edetic Acid / Q000494:pharmacology; D007425:Intracellular Membranes / Q000378:metabolism*; D007455:Iodine / Q000378:metabolism*; D050356:Lipid Metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D011863:Radioimmunoassay; D051381:Rats; D013974:Thyroxine / Q000378:metabolism*; D014285:Triiodothyronine, Reverse / Q000096:biosynthesis
D008054:Lipid Peroxides; D008315:Malondialdehyde; D014285:Triiodothyronine, Reverse; D007455:Iodine; D004492:Edetic Acid; D013974:Thyroxine