Total synthesis of edeine D.
Syntheses of the peptides with sequences postulated for active and inactive isomer of edeine D were carried out. The peptides obtained were identical with natural product in regard to chromatographic and electrophoretic properties. Biological data for synthesized compounds confirmed that in active and inactive isomer isoserine is linked with the alpha- or beta-amino group of alpha, beta-diaminopropionic acid, respectively.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001412:Bacillus subtilis / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004486:Edeine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000633:toxicity; D004926:Escherichia coli / Q000187:drug effects; D007202:Indicators and Reagents; D007536:Isomerism; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012706:Serratia marcescens / Q000187:drug effects; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D004486:Edeine; C039534:edeine D