Preparation of a biocompatible albumin-coated ion exchange resin for bilirubin removal from the blood of jaundiced newborns.
Removal of bilirubin by hemoperfusion with ion exchange resin particles is suggested to replace exchange transfusion of blood of jaundiced infants in some cases of unconjugated hyperbilirubinemia. The hemoperfusion system developed here consists of a packed bed of a macroreticular resin which is made biocompatible by a coating of a monomolecular layer of albumin. The choice of the appropriate ionic form of the resin and the proper albumin coating and crosslinking procedure assures a high bilirubin adsorption capacity and excellent blood compatibility of the resin. The albumin coated resin removes in vitro 80-90% of the bilirubin initially present in the plasma. The results encourage in vivo clinical studies.
D000327:Adsorption; D000418:Albumins / Q000627:therapeutic use*; D001663:Bilirubin / Q000097:blood*; D001672:Biocompatible Materials / Q000627:therapeutic use*; D004355:Drug Stability; D005976:Glutaral / Q000494:pharmacology; D006464:Hemoperfusion / Q000379:methods; D006801:Humans; D007231:Infant, Newborn; D007475:Ion Exchange Resins / Q000627:therapeutic use*; D007567:Jaundice, Neonatal / Q000097:blood / Q000628:therapy*; D008854:Microscopy, Electron
D000418:Albumins; D001672:Biocompatible Materials; D007475:Ion Exchange Resins; D001663:Bilirubin; D005976:Glutaral