The proliferative activity of carcinomas of the cervix after radiation therapy.
The findings obtained so far from 15 patients with advanced non-keratinizing squamous cell carcinoma of the cervix uteri show a growing fall in 3H-thymidine incorporation at different intervals during radiation therapy under the application of 2,000 to 5,000 rad. The radiogenic reduction of S-phase nuclei occurs at lower radiation doses than do changes in the histopathological structure; this reduction is however ambiguous, since it is no more than just a rough indication of the decreasing proliferative intensity.
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000532:radiotherapy; D002455:Cell Division / Q000528:radiation effects*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011879:Radiotherapy Dosage; D013936:Thymidine / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000532:radiotherapy
D013936:Thymidine