Ethylenediaminetetra(methylenephosphonic) acid (EDTPO) as a therapeutic chelating agent.
Ethylenediaminetetra(methylenephosphonic) acid (EDTPO), when administered as its calcium salt, is an effective antidote for acute intoxication by a number of metal ions. Significant antidotal action was found for the following cations: Cd2+, Ni2+, Zn2+, Pb2+, Be2+ and UO2+(2). Because EDTPO is capable of chelating more than one calcium ion, better results were obtained when the Ca2EDTPO complex was administered.
D000818:Animals; D002614:Chelating Agents / Q000627:therapeutic use*; D004492:Edetic Acid / Q000627:therapeutic use; D008297:Male; D008670:Metals / Q000506:poisoning; D051379:Mice; D008813:Mice, Inbred ICR; D009943:Organophosphorus Compounds / Q000627:therapeutic use*
D002614:Chelating Agents; D008670:Metals; D009943:Organophosphorus Compounds; C018940:(ethylenedinitrilo)-tetramethylenephosphonic acid; D004492:Edetic Acid