Prophylactic antibiotics in appendicectomy: a prospective double blind randomized study.
Our double blind prospective randomized trial comparing intravenous cefoxitin with rectal metronidazole in appendicectomy reveals both groups to be similar regarding basic data, with no significant difference in the results between the two drugs. Nearly all the wound infections occurred after the patient went home. Most were minor infections and the overall infection rate was 6%. The intravenous route was the more certain but the more expensive. Bacteriology suggests that the same flora were present in the appendiceal wall of normal and acute non-perforated appendices. This would suggest bacteriologically that the same risks exist with non-inflamed appendicectomy as occurs with inflamed non-perforated appendices. These findings support the use of short course prophylaxis in appendicectomy.
D000293:Adolescent; D000328:Adult; D001062:Appendectomy; D001065:Appendix / Q000382:microbiology; D002440:Cefoxitin / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D010865:Pilot Projects; D011292:Premedication; D011446:Prospective Studies; D011897:Random Allocation; D013488:Suppositories; D013530:Surgical Wound Infection / Q000517:prevention & control*
D013488:Suppositories; D008795:Metronidazole; D002440:Cefoxitin