Chemicals and cancer: initiation and promotion.
What happens during the latency period in tumorigenesis--the interval between exposure to a carcinogen and development of detectable neoplastic changes? A two-step process has been delineated: initiation, which is apparently irreversible and occurs at any carcinogen dose level, and promotion, which is dose- and time-dependent and thus may be a reversible step in tumor development.
D000434:Alcoholic Beverages; D000818:Animals; D001194:Asbestos; D002273:Carcinogens; D002274:Carcinogens, Environmental; D004041:Dietary Fats; D006801:Humans; D006846:Hydrocarbons, Halogenated; D008113:Liver Neoplasms / Q000139:chemically induced / Q000201:enzymology; D008175:Lung Neoplasms / Q000139:chemically induced; D009369:Neoplasms / Q000139:chemically induced*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D012907:Smoking
D002273:Carcinogens; D002274:Carcinogens, Environmental; D004041:Dietary Fats; D006846:Hydrocarbons, Halogenated; D001194:Asbestos