[Action of alkaloids from podophyllin on the response of pancreatic beta-cells of the rabbit to tolbutamide].
Some antineoplastic agents alter the microtubular-microfilamentous system involved in insulin release. The authors studied the effect of the podophyllotoxin derivate VM-26 and the epipodophyllotoxin derivative VP-16-213 on the insulin release by the pancreatic beta-cell after tolbutamide stimulation. VP-16-213 produced a slowing and partial inhibition of insulin release, and VM-26 inhibited the late stage of insulin release.
D000818:Animals; D005047:Etoposide / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D011034:Podophyllotoxin / Q000031:analogs & derivatives*; D011817:Rabbits; D013713:Teniposide / Q000494:pharmacology*; D014044:Tolbutamide / Q000494:pharmacology*
D007328:Insulin; D005047:Etoposide; D013713:Teniposide; D014044:Tolbutamide; D011034:Podophyllotoxin
Acción de los alcaloides del podifilino sobre la respuesta de la célula beta pancreática de conejos a la tolbutamida.