H-2-linked resistance to mastocytoma in male mice: immune response to a histocompatibility antigen on the X chromosome.
Male hybrids from a cross between female mice of strain C57BL/6Kh and males of strain DBA/2J lived longer after injection of P815 mastocytoma cells of DBA/2 origin than did their female siblings. Responses to the histocompatibility antigen on the X chromosome of the DBA/2 strain may be involved in resistance to the tumor. When the female parent was replaced with a C57BL/6Kh carrying one of several mutations in the H-2 region, this sex effect disappeared in some of the hybrid combinations. Thus, the H-2 complex appears to be involved in the regulation of the immune response to the X-linked histocompatibility antigen in this tumor model.
D000818:Animals; D005260:Female; D006183:H-2 Antigens / Q000276:immunology*; D006801:Humans; D007113:Immunity, Innate; D008297:Male; D012515:Mast-Cell Sarcoma / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D012730:Sex Chromosomes / Q000276:immunology*; D012737:Sex Factors; D014960:X Chromosome / Q000276:immunology*
D006183:H-2 Antigens