[Induction of T cells--producers of a macrophage migration-inhibitory factor by minor histocompatibility antigens].
The reaction of MIF-producing T cells was studied on the 1st, 6th and 13th days after intravenous immunization in vivo by irradiated spleen cells, immunized and immunizing strains of mice differing in: (a) H-2 antigens; (b) H-2 and minor histocompatibility antigens (non-H-2); (c) non-H-2 antigens, Mls identical; (d) non-H-2 antigens, Mls different. It was demonstrated that in combinations of mice differing in H-2 antigens as well as in H-2 and non-H-2 antigens, the reaction of MIF-producing cells was revealed already on the 1st day after immunization and maintained also on the 6th and 13th days. After intravenous immunization against non-H-2 antigens (Mls identical combination of mice) MIF-production was revealed on the 1st day, whereas in combination of mice differing in non-H-2 antigens and Mls locus on the 1st and 6th days after immunization. The data obtained show that in-vivo immunization by the minor transplantation antigens effectively induces MIF-producing T lymphocytes, and first of all, a special category of these cells--"early" MIF-producers.
D000818:Animals; D006183:H-2 Antigens / Q000276:immunology; D007114:Immunization / Q000379:methods; D008263:Macrophage Migration-Inhibitory Factors / Q000032:analysis / Q000096:biosynthesis*; D051379:Mice; D008815:Mice, Inbred Strains; D008912:Minor Histocompatibility Loci; D013154:Spleen / Q000276:immunology / Q000528:radiation effects; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors
D006183:H-2 Antigens; D008263:Macrophage Migration-Inhibitory Factors
Induktsiia T-kletok--proutsentov faktora podavleniia migratsii makrofagov minornymi antigenami gistosovmestimosti.