[Pre-operative endoscopic infusions of an adsorbent containing mitomycin C (MMC-CH44) in stomach cancer].
Small charcoal particles adsorbing Mitomycin C (MMC-CH) were used in the treatment of lymphnode metastasis of gastric cancer. Immediately after injection of MMC-CH into the gastric wall, lymph capillaries and regional lymphnodes were stained in black and the high concentration of MMC was delivered with charcoal particles. MMC-CH was injected preoperatively using endoscope into the gastric wall of 20 patients with gastric cancer. MMC-CH was observed in 70% of metastatic regional lymphnodes. Systemic side effect was not noted at all. Erosion and shallow ulcers were observed at the site of injection but no perforation occurred.
D000327:Adsorption; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D002606:Charcoal; D005773:Gastroscopy / Q000379:methods; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage*; D014677:Pharmaceutical Vehicles; D011300:Preoperative Care; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology
D000903:Antibiotics, Antineoplastic; D008937:Mitomycins; D014677:Pharmaceutical Vehicles; D002606:Charcoal; D016685:Mitomycin