Myoclonic, atonic, and absence seizures following institution of carbamazepine therapy in children.
Five children, aged 3 to 11 years, treated with carbamazepine for epilepsy, had an acute aberrant reaction characterized by the onset of myoclonic, atypical absence and/or atonic (minor motor) seizures within a few days. When the carbamazepine was discontinued, two of the children returned to their former state very quickly, two had the minor motor seizures resolve in 3 and 6 months, and one had the seizures persist. The child in whom the seizures persisted was later found to have ceroid lipofuscinosis. The other children are doing well on other anticonvulsants.
D002220:Carbamazepine / Q000009:adverse effects* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D004831:Epilepsies, Myoclonic / Q000139:chemically induced*; D004832:Epilepsy, Absence / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male
D002220:Carbamazepine