Development of Aspergillus sinusitis in a patient receiving amphotericin B. Treatment with granulocyte transfusions.
Fulminant Aspergillus sinusitis is a disease of immunocompromised hosts strongly associated with neutropenia. A case of sinusitis due to Aspergillus flavus that developed in a patient with acute leukemia during the third week of treatment with amphotericin B is described. Indium 111-labeled white blood cell scanning demonstrated uptake of granulocytes into the involved sinuses. Thereafter, use of granulocyte transfusions was associated with stabilization of the patient's clinical course.
D000666:Amphotericin B / Q000627:therapeutic use*; D001228:Aspergillosis / Q000628:therapy*; D001231:Aspergillus flavus / Q000302:isolation & purification; D001803:Blood Transfusion; D005260:Female; D006098:Granulocytes / Q000637:transplantation*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008875:Middle Aged; D010256:Paranasal Sinuses / Q000382:microbiology; D012852:Sinusitis / Q000628:therapy*
D000666:Amphotericin B