Reversible retinal vasospasm in magnesium-treated hypertension despite no significant change in blood pressure.
8 young, untreated, hypomagnesemic patients with a recent onset of high-renin essential hypertension, were treated with 750 mg Mg oxide daily. Only functional (vasospastic) lesions were observed in their retinal vessels. After 3 months of therapy, despite no significant change in blood pressure, complete reversal of the retinal changes was observed. The retinal vascular changes could be attributable to vasospasm secondary to hypomagnesemia since serum Mg levels normalized during treatment.
D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008274:Magnesium / Q000097:blood / Q000627:therapeutic use*; D012083:Renin / Q000097:blood; D012171:Retinal Vessels / Q000503:physiopathology*; D014661:Vasoconstriction / Q000187:drug effects
D012083:Renin; D008274:Magnesium