[Potentiation by pimozide of the effects of LHRH-A on hypophyseal gonadotropin secretion, ovulation and spermiation in the common carp (Cyprinus carpio)].
During the reproductive season in August, we administered to adult male and female Carp an LHRH analog (LHRH-A = D-trp6EA-LHRH) (50 micrograms/kg) alone or in association with pimozide, a dopamine inhibitor (10 mg/kg). LHRH-A caused the circulating portal level of gonadotropin to rise significantly in males and less in females. Spermiation was stimulated in the males and oocyte maturation in females but there was no ovulation. An infection of pimozide and then of LHRH-A 6 h later significantly increased c-GTH secretion and spermiation more than LHRH-A given alone, and induced ovulation in the females.
D000818:Animals; D002347:Carps; D004357:Drug Synergism; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives* / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D010060:Ovulation / Q000187:drug effects*; D010868:Pimozide / Q000494:pharmacology*; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D012621:Seasons; D013094:Spermatozoa / Q000187:drug effects / Q000502:physiology*
D010868:Pimozide; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Potentialisation par le pimozide des effets du LHRH-A sur la sécrétion gonadotrope hypophysaire, l'ovulation et la spermiation chez la Carpe commune (Cyprinus carpio).