Iotrol, a new myelographic agent: 1. Radiography, CT, CSF clearance, and brain penetration.
Four new myelographic agents, metrizamide, iopamidol, iohexol, and iotrol, were studied in the subarachnoid space of cynomolgus monkeys. Plain films and computed tomographic scans documented the transport of each material throughout the space and into the brain. At the concentration used (300 mg I/ml), all gave good radiopacity for myelography and delineation of the cerebral subarachnoid space. All four cleared similarly from the ventricular system. Metrizamide, however, penetrated the brain in greater degree and persisted longer than the other three agents. Next in persistence was iopamidol and least, and both statistically equal, iotrol and iohexol.
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000000981:diagnostic imaging; D014695:Cerebral Ventriculography; D003287:Contrast Media / Q000009:adverse effects / Q000378:metabolism; D007463:Iodobenzoates; D007479:Iopamidol; D007483:Iothalamic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D008252:Macaca fascicularis; D008657:Metabolic Clearance Rate; D008793:Metrizamide / Q000378:metabolism; D009192:Myelography / Q000379:methods*; D013346:Subarachnoid Space; D014283:Triiodobenzoic Acids / Q000009:adverse effects / Q000378:metabolism
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D007483:Iothalamic Acid; C033300:iotrolan; D007479:Iopamidol; D008793:Metrizamide