Monoclonal gammopathy (IgM-kappa) in a patient with Burkitt's lymphoma. Case report and literature review.
A monoclonal immunoglobulin, IgM-kappa, was detected in the serum of a patient with Burkitt's lymphoma. This rarely reported finding raises the possibility that undifferentiated neoplastic lymphoreticular cells in this disorder have the capacity to synthesize immunoglobulins. Gel-exclusion and ion-exchange column chromatography, as well as immunofixation, allowed for heavy- and light-chain characterization of the subtle monoclonal component.
D001797:Blood Protein Electrophoresis; D002051:Burkitt Lymphoma / Q000150:complications / Q000276:immunology* / Q000473:pathology; D002648:Child; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications / Q000276:immunology* / Q000473:pathology; D007122:Immunoelectrophoresis; D007147:Immunoglobulin Light Chains / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D008297:Male
D007147:Immunoglobulin Light Chains; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains