[Increase of circulating HLA DR+ T lymphocytes in psoriasis].
HLA DR molecules on the surface of T lymphocytes evidences the immune cell activation. In the course of disease with immunopathogenic mechanisms and after immunostimulation the level of peripheral T HLA DR+ lymphocytes increases. In psoriasis, it was previously demonstrated the existence of T HLA DR+ lymphocytes in the skin lesions. This phenomenon suggests an in situ activation of T cells. In this paper we show an increase of circulating T HLA DR+ lymphocytes in 12 patients with active psoriasis (5.81% +/- 3.17) compared to healthy controls (2.02% +/- 0.47). The difference was significative (P less than 0.01). The authors suggest the systemic activation of T cells in psoriasis that could be controlled by the HLA system.
D000328:Adult; D005260:Female; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007964:Leukocytosis / Q000209:etiology; D008213:Lymphocyte Activation; D008297:Male; D011565:Psoriasis / Q000150:complications / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II
Aumento de linfocitos T HLA DR+ circulantes en psoriasis.