Monocytic origin of foam cells in human atherosclerotic plaques.
Foam cells in 4 human atherosclerotic plaques reacted with 3 rat monoclonal antibodies directed against T.200 ('anti-leucocyte common' antibody), HLA-Class II molecules and macrophage cytoplasm, respectively. Smooth muscle cells did not react. The results support the view that foam cells are monocyte-derived macrophages.
D000328:Adult; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001011:Aorta / Q000473:pathology*; D001161:Arteriosclerosis / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D005487:Foam Cells / Q000145:classification* / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D008264:Macrophages / Q000145:classification*; D008297:Male; D008875:Middle Aged; D009000:Monocytes; D051381:Rats
D000911:Antibodies, Monoclonal