A functional cyclooxygenase enzyme is not required for mediation of the pleiotropic effects of human alpha or beta interferon.
Aspirin, indomethacin, and phenbutazone at 50 microM concentration inhibit cyclooxygenase in cultured human foreskin fibroblasts as evidenced by the suppression of the major prostaglandin species which accumulate in the culture medium. In contrast to data reported for mouse interferon on target mouse cells, these agents have no effect on the induction of antiviral activity by human alpha or beta interferons. Similarly, these agents have no effect on interferon induced inhibition of cell growth in vitro or on interferon induced natural killer cell activity.
D001241:Aspirin / Q000494:pharmacology; D001943:Breast Neoplasms / Q000378:metabolism; D002460:Cell Line; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007370:Interferon Type I / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D014762:Viral Interference / Q000187:drug effects; D014846:Vulvar Neoplasms / Q000378:metabolism
D007370:Interferon Type I; D011451:Prostaglandin-Endoperoxide Synthases; D010653:Phenylbutazone; D001241:Aspirin; D007213:Indomethacin