A comparison of bupropion, dextroamphetamine, and placebo in mixed-substance abusers.
The subjective, behavioral, and physiological effects of bupropion, a nontricyclic antidepressant, were compared with those of dextroamphetamine and placebo in a randomized double-blind crossover study. The volunteers who participated were multiple-drug abusers. Six acute drug treatments, three doses of bupropion (100, 200, 400 mg), two doses of dextroamphetamine (15, 30 mg), and placebo were administered orally at intervals of not less than 72 h. Results indicated that the subjective effects of amphetamine as measured by the Addiction Research Center Inventory (ARCI) differed markedly from bupropion and placebo. Bupropion, in contrast to amphetamine, had no peripheral sympathomimetic effects and did not reduce appetite or caloric intake.
D000328:Adult; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001143:Arousal / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects; D016642:Bupropion; D002986:Clinical Trials as Topic; D003913:Dextroamphetamine / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D002149:Energy Intake / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D011427:Propiophenones / Q000627:therapeutic use*; D012119:Respiration / Q000187:drug effects; D019966:Substance-Related Disorders / Q000188:drug therapy*
D000928:Antidepressive Agents; D011427:Propiophenones; D016642:Bupropion; D003913:Dextroamphetamine