Effectiveness of oral sodium cromoglycate (SCG) in preventing food allergy in children.
The efficacy of oral SCG in preventing food allergy symptoms in children was investigated. Ten children with cow's milk and/or egg IgE-mediated allergy were selected for this study. The subjects were challenged with the offending food before and after a seven-day pre-treatment period with oral SCG (30 mg/kg b.w. per day). Full protection was achieved in six out of eight children with cow's milk allergy and in four of the five children with egg allergy. The mode of action of SCG in the prevention of clinical manifestations of food allergy is discussed.
D000284:Administration, Oral; D000293:Adolescent; D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D002364:Caseins / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000627:therapeutic use*; D004531:Eggs; D005260:Female; D005512:Food Hypersensitivity / Q000178:diet therapy / Q000517:prevention & control*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007768:Lactalbumin / Q000276:immunology; D008297:Male; D008892:Milk; D010047:Ovalbumin / Q000276:immunology; D012882:Skin Tests; D012884:Skin Window Technique
D002364:Caseins; D007073:Immunoglobulin E; D010047:Ovalbumin; D007768:Lactalbumin; D004205:Cromolyn Sodium