Interactions of beta-lactam antibiotics and antineoplastic agents.
The in vitro interactions of four beta-lactam antibiotics and five antineoplastic agents were examined with 100 clinically isolated strains of four species of gram-negative bacilli. Generally, by the checkerboard dilution method, beta-lactam antibiotics, when tested in combination with mitomycin C, bleomycin, or 5-fluorouracil, showed synergistic action, whereas when tested in combination with carboquone, they showed antagonistic action. Almost no combinations of adriamycin showed the interactions. Among beta-lactam antibiotics, piperacillin was more frequently synergistic than cefoperazone, cefazolin, or carbenicillin when tested in combination with each antineoplastic agent against various species.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004347:Drug Interactions; D008826:Microbial Sensitivity Tests; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D047090:beta-Lactams
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D008937:Mitomycins; D047090:beta-Lactams; D016685:Mitomycin