Lactase activity is under hormonal control in the intestine of adult rat.
In the adult rat, starvation during 48 hours led to a three fold increase of lactase specific activity in the intestinal brush border membranes. Thyroxine injection during the three days before death (0.5 micrograms/g daily) inhibited the stimulation of lactase activity induced by starvation without modifying sucrase activity whereas hydrocortisone injections (25 micrograms/g daily) or thyroidectomy did not modify the stimulatory effect of starvation on lactase activity. These results suggests a specific hormonal control of intestinal lactase activity in the rat.
D000818:Animals; D005696:Galactosidases / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000201:enzymology; D007583:Jejunum / Q000201:enzymology*; D008871:Microvilli / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D013217:Starvation; D013393:Sucrase / Q000378:metabolism; D013965:Thyroidectomy; D013974:Thyroxine / Q000494:pharmacology / Q000502:physiology*; D001616:beta-Galactosidase / Q000378:metabolism*
D005696:Galactosidases; D001616:beta-Galactosidase; D013393:Sucrase; D013974:Thyroxine; D006854:Hydrocortisone