Ly-5 molecular forms in congenitally immunodeficient mice.
Four different molecular weight forms of the Ly-5 antigen were defined by immunochemical methods on the cell surface of murine spleen cells using a monoclonal antibody. Each form was selectively expressed by cells belonging to different lineages. A 220,000-dalton molecule was associated with B cells, a 200,000-dalton molecule with macrophages and two antigens of 185,000 and 175,000 daltons, respectively, were detected on the cell surface of normal thymocytes. The 185,000-dalton Ly-5 molecule was not found on the lymphoid cells of immunodeficient mice, like the athymic nude or the athymic-asplenic (LASAT) mice, suggesting that cells bearing this Ly-5 molecule have a significant function in some T-dependent immune responses.
D000818:Animals; D000950:Antigens, Ly / Q000235:genetics*; D000951:Antigens, Neoplasm / Q000276:immunology; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics / Q000276:immunology; D008817:Mice, Mutant Strains / Q000235:genetics / Q000276:immunology*; D008819:Mice, Nude / Q000235:genetics / Q000276:immunology*; D008970:Molecular Weight; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology
D000950:Antigens, Ly; D000951:Antigens, Neoplasm