Genetic variability of purine nucleoside phosphorylase activity in the mouse: relationship to Np-1 and Np-2.
A survey of 37 inbred strains for erythrocyte purine nucleoside phosphorylase activity showed a greater than threefold range. Six of these strains had significantly greater activity than the others, and all of the high-activity strains had the Np-2 electrophoretic band. The high-purine nucleoside phosphorylase activity trait corresponding to Np-2 was inherited in an autosomal codominant manner and minor differences were apparent in thermal and kinetic properties between low- and high-activity strains. This work provides further support for there being either two structural loci for purine nucleoside phosphorylase, Np-1 and Np-2, or a regulatory-modifier locus.
D000818:Animals; D004912:Erythrocytes / Q000201:enzymology; D005796:Genes; D014644:Genetic Variation; D006358:Hot Temperature; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics* / Q000378:metabolism; D010430:Pentosyltransferases / Q000235:genetics*; D011683:Purine-Nucleoside Phosphorylase / Q000235:genetics*
D010430:Pentosyltransferases; D011683:Purine-Nucleoside Phosphorylase