Cerebral blood flow in children with intractable epilepsy.
A good correlation of Doppler internal carotid blood velocity determinations with hemispheric blood flow measurements by the 133-xenon inhalation method was demonstrated in 14 epileptic patients without abnormal CT findings. The highest correlation was seen between the flow of gray matter (F1) and the internal carotid end-diastolic velocity (d) (left side r = 0.841, right side r = 0.817). As end-diastolic velocity (d) well correlated with the value obtained by the 133-xenon inhalation method, the d value was compared between 77 healthy children and 13 patients with intractable epilepsy. The mean d value of both internal carotid arteries in patients was 16.7 +/- 2.9 mm (mean +/- SD), and that of healthy children 20.9 +/- 4.3 mm, the difference being statistically significant. The low cerebral blood flow in patients might be due to multiple antiepileptic drugs administered and/or mental retardation and cerebral hypofunction related to seizures.
D000293:Adolescent; D000927:Anticonvulsants / Q000008:administration & dosage; D002343:Carotid Artery, Internal; D002560:Cerebrovascular Circulation; D002648:Child; D004828:Epilepsies, Partial / Q000503:physiopathology; D004827:Epilepsy / Q000150:complications / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000150:complications; D008297:Male; D014463:Ultrasonography; D014980:Xenon Radioisotopes
D000927:Anticonvulsants; D014980:Xenon Radioisotopes