Transfer of sensitised Lyt 2+ cells triggers acute rejection of pancreatic islet allografts.
The cellular requirements for rejection of cultured islet allografts, a tissue expressing only class I alloantigens, have been studied. The results obtained show that sensitised Thy 1+, Lyt 2+ lymphocytes and not Lyt 2- lymphocytes trigger acute graft rejection.
D000818:Animals; D000950:Antigens, Ly / Q000145:classification / Q000276:immunology*; D003921:Diabetes Mellitus, Experimental / Q000628:therapy; D006084:Graft Rejection; D007116:Immunization, Passive; D016381:Islets of Langerhans Transplantation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D010641:Phenotype; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology / Q000637:transplantation*
D000950:Antigens, Ly