Comparative study of hepatic microsomal and cytosolic enzyme activities in three murine strains.
A comparative study on hepatic microsomal p-nitroanisole-O-demethylase, aminopyrine-N-demethylase, NADPH-cytochrome c reductase and cytosolic glutathione (GSH) S-transferase was performed in both sexes of C3Hf, C57BL/6J and DBA/2 mice. In control and phenobarbital (PB)-induced mice similarities in hepatic microsomal activities were found with slight variations among strains and sexes. The Ah locus nonresponsive DBA/2 mice showed uninduced microsomal activities after beta-naphthoflavone (BNF), as expected; the other two strains were induced by BNF to a similar extent. Differences in cytosolic GSH S-transferase were detected among strains and sexes; C57BL/6J mice showed the highest basal and induced levels. The males of all the three strains examined were found to have higher GSH S-transferase activity than females.
D000633:Aminopyrine N-Demethylase / Q000378:metabolism*; D000818:Animals; D003600:Cytosol / Q000201:enzymology; D005260:Female; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H / Q000378:metabolism; D008810:Mice, Inbred C57BL / Q000378:metabolism; D008811:Mice, Inbred DBA / Q000378:metabolism; D008815:Mice, Inbred Strains / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism*; D009575:Nitroanisole O-Demethylase / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D013045:Species Specificity
D009575:Nitroanisole O-Demethylase; D010088:Oxidoreductases; D000633:Aminopyrine N-Demethylase; D009251:NADPH-Ferrihemoprotein Reductase