Cholinergic effect of 2-deoxy-D-glucose on plasma glucagon levels in conscious rats.
The present study was conducted to investigate how the in vivo glucagon secretory response to 2-deoxy-D-glucose relates to control of nervous system. Plasma glucagon levels in the rat were significantly elevated by 2-deoxy-D-glucose administration (40 mg/100 g body weight). That response was suppressed by hexamethonium, a nicotinic ganglionic blocker. By contrast, treatment with atropine (5 mg/100 g body weight), a muscarinic antagonist, had no effect on glucagon secretion due to the same dose of the deoxysugar, whereas the drug totally inhibited the response to a lower concentration of the deoxysugar. Administration of 2-deoxy-D-glucose significantly elevated plasma epinephrine levels, and it was suppressed by hexamethonium. Plasma insulin levels were not so changed despite hyperglycaemia. In conclusion, the present study suggests that 2-deoxy-D-glucose may act on cholinergic nerve system to stimulate the release of glucagon and epinephrine.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D004837:Epinephrine / Q000097:blood; D005934:Glucagon / Q000097:blood*; D006584:Hexamethonium Compounds / Q000494:pharmacology; D007328:Insulin / Q000097:blood; D008297:Male; D010862:Pilocarpine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D003837:Deoxy Sugars; D006584:Hexamethonium Compounds; D007328:Insulin; D010862:Pilocarpine; D001285:Atropine; D002217:Carbachol; D005934:Glucagon; D003847:Deoxyglucose; D004837:Epinephrine