[Cytomorphological study of the mucosa of the hamster cheek pouch in the process of carcinogenesis].
An 0.5% acetone solution of 7,12-dimethylbenz(a) anthracene was applied to the mucosa of the cheek pouch of 68 Syrian male hamsters. Cytological examination of mucosa samples obtained from the cheek pouch was carried out, and the bioptates and tissues of dead animals were studied histologically. Squamous cell carcinoma of the pouch was identified in 100%. Cytologically-confirmed hyperplasia and dysplasia of the epithelium were found to precede cancer development.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology; D000818:Animals; D001706:Biopsy; D002610:Cheek; D006224:Cricetinae; D008198:Lymph Nodes / Q000473:pathology; D008647:Mesocricetus; D009061:Mouth Mucosa / Q000473:pathology*; D009062:Mouth Neoplasms / Q000139:chemically induced / Q000473:pathology*; D013997:Time Factors
D015127:9,10-Dimethyl-1,2-benzanthracene
Tsitomorfologicheskoe issledovanie slizistoĭ obolochki zashchechnogo meshka khomiachka v protsesse kantserogeneza.