Effect of cyclosporin A on lymphocyte activation by the calcium ionophore A23187.
The activation of pig lymphocytes by the divalent cation ionophore A23187 is more sensitive to inhibition by cyclosporin A than is activation by plant lectins such as concanavalin A. Complete inhibition of A23187-induced activation was seen at a cyclosporin A concentration of 0.3 micrograms/ml. The very early stimulation of nucleoside uptake induced by A23187 was not affected by cyclosporin A, but other early metabolic changes occurring during the first few hours after activation were inhibited.
D000409:Alanine / Q000378:metabolism; D000818:Animals; D000001:Calcimycin / Q000494:pharmacology*; D003208:Concanavalin A / Q000494:pharmacology; D003524:Cyclosporins / Q000494:pharmacology*; D004306:Dose-Response Relationship, Immunologic; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000378:metabolism; D008715:Methionine / Q000378:metabolism; D013552:Swine; D013936:Thymidine / Q000378:metabolism; D014529:Uridine / Q000378:metabolism
D003524:Cyclosporins; D003208:Concanavalin A; D000001:Calcimycin; D008715:Methionine; D000409:Alanine; D013936:Thymidine; D014529:Uridine