Differential effects of gamma interferon on expression of HLA class II molecules controlled by the DR and DC loci.
Interferon-gamma affected the expression of the products of the immunoassociated antigen complex by a differential modulation of DR- and DC-locus-controlled molecules. In melanoma M14 cells treated with interferon-gamma, levels of DR molecules were increased two- to threefold, whereas levels of DC molecules were increased six- to sevenfold. Similar effects were induced on the two allelic products of each locus.
D002460:Cell Line; D005786:Gene Expression Regulation; D005802:Genes, MHC Class II; D006680:HLA Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen; D015808:HLA-DR6 Antigen; D000949:Histocompatibility Antigens Class II; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D008545:Melanoma
D006680:HLA Antigens; D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D015804:HLA-DR4 Antigen; D015808:HLA-DR6 Antigen; D000949:Histocompatibility Antigens Class II; D007371:Interferon-gamma