[Comparison of the levels of chromosome aberration and sister chromatid exchange induced by chemical mutagens in vitro].
Dose dependencies of the induction of sister chromatid exchanges (SCEs) and chromosome aberrations were studied under in vivo exposure of mouse bone marrow cells to 5 alkylating agents. The efficacy of the induction of SCEs for all the substances was 20 to 60 times higher than that of the induction of chromosome aberrations. It was demonstrated that SCEs induced by chemical mutagens in vivo and in vitro are more sensitive tests than chromosome aberrations.
D001388:Aziridines / Q000633:toxicity; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000187:drug effects*; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008937:Mitomycins / Q000633:toxicity; D009153:Mutagens; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013852:Thiotepa / Q000633:toxicity
D001388:Aziridines; D008937:Mitomycins; D009153:Mutagens; D013852:Thiotepa; C026480:inproquone; C007526:dipin
Sopostavlenie urovnia sestrinskikh khromatidnykh obmenov i khromosomnykh aberratsiĭ, indutsirovannykh khimicheskimi mutagenami in vitro.