Measurement of the disaggregating effect of prostacyclin (PGI2) in anaesthetized dogs.
The disaggregating effect of PGI2 was measured in a modified in vivo model first described by Hornstra (5). The arterial blood of mongrel dogs was directed through an extracorporeal filter by a roller pump, and the pressure before the filter was measured. The filter becomes spontaneously occluded within a few minutes, and as a results the pressure before the filter increases continuously. PGI2 administered before the filter or intravenously produced dose-related reduction in filtration pressure. This simple technique seems to be usefull for determining the dis aggregatory effects of prostacyclin and other substances.
D000818:Animals; D001166:Arteriovenous Shunt, Surgical; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D011464:Epoprostenol / Q000494:pharmacology*; D005263:Femoral Artery; D005268:Femoral Vein; D010974:Platelet Aggregation / Q000187:drug effects*
D011464:Epoprostenol