A benzodiazepine antagonist is an anticonvulsant in an animal model for limbic epilepsy.
A benzodiazepine antagonist, Ro 15-1788, completely abolishes the sedative/ataxic effects of diazepam but, at the same dose (10 mg/kg, i.p.), it, like diazepam, slows the development of kindled seizures. This suggests that the anticonvulsant and sedative effects of benzodiazepines are mediated via different receptors and that Ro 15-1788 or similar compounds may be useful anticonvulsants.
D000818:Animals; D000927:Anticonvulsants; D001570:Benzodiazepinones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D003975:Diazepam / Q000008:administration & dosage / Q000494:pharmacology; D004347:Drug Interactions; D005442:Flumazenil; D007696:Kindling, Neurologic / Q000187:drug effects; D008297:Male; D051381:Rats; D012640:Seizures / Q000188:drug therapy*
D000927:Anticonvulsants; D001570:Benzodiazepinones; D005442:Flumazenil; D003975:Diazepam