Devastating distal arterial trauma and continuous intraarterial infusion of tolazoline.
Trauma due to motor vehicles accident and urban violence have made distal arterial reconstruction an increasingly important part of the surgeon's work. During the 20 month period from October 1980 to May 1982, 13 patients with below the knee and 2 patients with forearm trauma had nonviable extremities despite fastidious vascular and orthopedic reconstruction. A continuous intraarterial infusion of tolazoline into the femoral or brachial arteries restored vascular perfusion and viability in 13 of 15 patients (87 percent), with eventual limb salvage in 67 percent. Seven of 15 patients (47 percent) had transient systemic hypertension. There was no mortality. There exists in patients with these catastrophic injuries a local low-flow state due to a combination of distal arterial spasm and venous outflow obstruction. Tolazoline, a peripheral alpha-adrenergic blocking agent, increases blood flow, albeit nonnutritionally, and thus theoretically prevents thrombosis due to stasis in the repaired distal vessel. When limb loss seems inevitable, a trial of intraarterial tolazoline is justified.
D000063:Accidents, Traffic; D000293:Adolescent; D000328:Adult; D016512:Ankle Injuries; D001158:Arteries / Q000293:injuries*; D002648:Child; D003161:Compartment Syndromes / Q000601:surgery; D005260:Female; D005263:Femoral Artery; D005264:Femoral Fractures / Q000601:surgery; D005542:Forearm / Q000098:blood supply; D005597:Fractures, Open / Q000601:surgery; D006801:Humans; D007261:Infusions, Intra-Arterial; D007718:Knee Injuries / Q000601:surgery; D007866:Leg / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D013978:Tibial Fractures / Q000601:surgery; D014043:Tolazoline / Q000008:administration & dosage*; D014947:Wounds and Injuries / Q000188:drug therapy / Q000601:surgery*; D014948:Wounds, Gunshot / Q000188:drug therapy / Q000601:surgery*
D014043:Tolazoline