Histochemical evidence for the role of Ca2+ and neutral protease in the development of the subacute myopathy induced by organophosphorous compounds.
A temporal and causal relationship has been established between inhibition of acetylcholinesterase (AChE) by organophosphorous compounds, accumulation of Ca2+, an increase of neutral protease activity and the development of the ultrastructural signs of subacute myopathy.
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D006651:Histocytochemistry; D007531:Isoflurophate / Q000633:toxicity; D009045:Motor Endplate / Q000201:enzymology; D009132:Muscles / Q000648:ultrastructure; D009135:Muscular Diseases / Q000139:chemically induced* / Q000378:metabolism; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010447:Peptide Hydrolases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D009943:Organophosphorus Compounds; D007531:Isoflurophate; D000110:Acetylcholinesterase; D010447:Peptide Hydrolases; D002118:Calcium