Ulex europaeus I lectin as a marker for tumors derived from endothelial cells.
Some skin and soft tumors, which generally are assumed to be derived from endothelial cells or blood vessels, were characterized with fluorochrome-labeled Ulex europaeus I agglutinin (UEA I), recently shown to bind specifically to endothelial cells in various normal human tissues. The staining pattern was compared with that obtained with immunostaining using antibodies against factor-VIII-related antigen (FVIII-RAG), a known marker for endothelial cells. The results showed that UEA-I is a specific and a more sensitive marker for the endothelial cells in benign vascular lesions as compared with anti-FVIII-RAG. UEA-I also stained many neoplastic cells of endothelial sarcomas, which generally were negative for FVIII-RAG. Melanomas, anaplastic carcinomas, and other types of sarcomas were negative for both UEA-I and FVIII-RAG. The results suggest that UEA-I lectin is a specific and sensitive adjunct tool in demonstrating endothelial cells and endothelial derivation of human tumors.
D000941:Antigens / Q000032:analysis; D004727:Endothelium / Q000473:pathology*; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D006391:Hemangioma / Q000473:pathology; D006393:Hemangiopericytoma / Q000473:pathology; D006394:Hemangiosarcoma / Q000473:pathology; D006801:Humans; D037102:Lectins; D009383:Neoplasms, Vascular Tissue / Q000473:pathology*; D037121:Plant Lectins; D012514:Sarcoma, Kaposi / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology; D012983:Soft Tissue Neoplasms / Q000473:pathology; D014841:von Willebrand Factor
D000941:Antigens; D037102:Lectins; D037121:Plant Lectins; C036850:Ulex europaeus lectins; D014841:von Willebrand Factor; D005169:Factor VIII