Effect of nicotinic acid associated with retinol and tocopherols on plasma lipids in hyperlipoproteinaemic patients.
Twelve hypercholesterolaemic patients, with or without hypertriglyceridaemia, were treated sequentially with 600 mg nicotinic acid alone per day and 300 mg nicotinic acid plus 60,000 U retinol and 140 mg tocopherols per day, each treatment being given for 30 days in random order sequence. Plasma concentrations of lipid fractions were determined before the start of the study and at the end of each treatment period. Both treatments resulted in a significant decrease in total cholesterol and LDL-cholesterol; HDL-cholesterol showed a small but significant increase and plasma triglycerides presented a variable behaviour pattern of change. The difference between the hypolipidaemic effects of nicotinic acid alone and the lower dose given with Vitamins A and E was small but the combination seemed to be more effective. No side-effects were reported with either treatment.
D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood / Q000188:drug therapy*; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009525:Niacin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011897:Random Allocation; D014280:Triglycerides / Q000097:blood; D014801:Vitamin A / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014810:Vitamin E / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D014801:Vitamin A; D014810:Vitamin E; D009525:Niacin