Neurotensin regulation of TSH secretion in the rat.
Tri-iodothyronine stimulates neurotensin secretion from rat hypothalami in vitro. Propylthiouracil treatment of rats is associated with a decrease in anterior pituitary neurotensin content, an increase in hypothalamic content and an impaired release of peptide from hypothalami in vitro. In addition neurotensin has a direct inhibitory effect on TRH-stimulated TSH release from anterior pituitary in vitro. These observations suggest a physiological role for neurotensin in the control of TSH secretion in the rat.
D000818:Animals; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009496:Neurotensin / Q000494:pharmacology*; D011441:Propylthiouracil / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013972:Thyrotropin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D013974:Thyroxine / Q000494:pharmacology
D009496:Neurotensin; D013973:Thyrotropin-Releasing Hormone; D011441:Propylthiouracil; D013972:Thyrotropin; D013974:Thyroxine