Study of the effects of insulin on the migration of Hymenolepis diminuta in rats.
The effects of insulin on worm (Hymenolepis diminuta) migration was studied. Insulin injection (20 U/kg, s.c.) significantly increased gastric acid output but did not affect the serotonin content of blood, intestinal lumen or worms. The drug produced, dose-dependently, posteriad migration of the worms in rats without pylorus-ligation but ligation of the pylorus prevented this migration. It is concluded that the hypersecretion of gastric acid induced by insulin is responsible for the posteriad migration of H. diminuta in rats.
D000818:Animals; D006925:Hymenolepiasis / Q000469:parasitology / Q000662:veterinary*; D006926:Hymenolepis / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology; D007279:Injections, Subcutaneous / Q000662:veterinary; D007328:Insulin / Q000008:administration & dosage / Q000494:pharmacology*; D007421:Intestine, Small / Q000469:parasitology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012376:Rodent Diseases / Q000469:parasitology*; D012701:Serotonin / Q000378:metabolism
D007328:Insulin; D012701:Serotonin