Steroidal thiourea and thiazoline derivatives: synthesis and in vitro effects on bovine pancreatic ribonuclease activity.
Two novel series of steroidal derivatives containing various thiourea and substituted thiazoline moieties attached to the 2- or 4-position of estrone were synthesized and examined for in vitro effect on bovine pancreatic ribonuclease activity. All compounds studied exhibited a catabolic activity. The steroidal thiazoline derivatives were more potent activators of ribonuclease than the steroidal thioureas.
D000818:Animals; D002417:Cattle; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D012259:Ribonuclease, Pancreatic / Q000037:antagonists & inhibitors*; D013256:Steroids / Q000138:chemical synthesis*; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013890:Thiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D013256:Steroids; D013844:Thiazoles; D012259:Ribonuclease, Pancreatic; D013890:Thiourea