Attenuation of pilocarpine-induced hypothermia in response to chronic administration of choline.
Chronic treatment of rats with choline caused a decrease in the hypothermic response to pilocarpine. The action of choline on the muscarinic receptors is consistent with electrophysiological and binding studies, supporting a direct muscarinic action for choline. Administration of direct muscarinic agonists has been shown to cause a decrease in the number of muscarinic receptors. Thus, the long-term use of cholinergic precursors could have some adverse effects on central cholinergic functioning.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D002794:Choline / Q000494:pharmacology*; D008297:Male; D010862:Pilocarpine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D010862:Pilocarpine; D002794:Choline