Reversal of dietary-induced insulin resistance in muscle of the rat by adenosine deaminase and an adenosine-receptor antagonist.
Transfer of young rats from a maintenance diet to a breeding diet plus 10% sucrose in the drinking water for 4 weeks caused the development of insulin resistance. Inclusion of the enzyme adenosine deaminase or the adenosine-receptor antagonist 8-phenyltheophylline caused a marked increase in the sensitivity of the soleus-muscle strips isolated from the diet-induced insulin-resistant rats: the concentration of insulin giving 50% of maximum response of glycolysis shifted from 500 to less than 20 microunits/ml.
D000243:Adenosine Deaminase / Q000494:pharmacology*; D000818:Animals; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D006003:Glycogen / Q000096:biosynthesis; D007328:Insulin / Q000494:pharmacology; D007333:Insulin Resistance; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D009700:Nucleoside Deaminases / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013395:Sucrose / Q000494:pharmacology; D013806:Theophylline / Q000031:analogs & derivatives* / Q000494:pharmacology
D004040:Dietary Carbohydrates; D007328:Insulin; D007773:Lactates; D019344:Lactic Acid; D013395:Sucrose; D006003:Glycogen; D013806:Theophylline; C028322:8-phenyltheophylline; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase