Study of complement effects on kinetics of immune precipitation.
Influence of complement on the kinetics of immune precipitation was investigated by using simple kinetic tests. In the early phase of immune precipitate (IPPT) formation, it was demonstrated that complement caused inhibition of precipitation only. After formation of a certain critical IPPT mass, alternative pathway-dependent enhancement of precipitation was observed, followed by solubilization of 'enhanced' IPPT and, at last, by solubilization of preformed IPPT. Contrary to inhibition and IPPT solubilization, enhancement of IPPT formation does not change IPPT ability to react with fresh complement.
D000818:Animals; D011232:Chemical Precipitation; D003165:Complement System Proteins / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D007158:Immunologic Techniques; D007700:Kinetics; D011817:Rabbits
D003165:Complement System Proteins