Phagocytosis and antimicrobicidal activity of polymorphonuclear leucocytes against gentamicin-sensitive and resistant strains of Pseudomonas aeruginosa.
The ability of human polymorphonuclear leucocytes (PMNs) to ingest and kill gentamicin-sensitive and resistant Pseudomonas aeruginosa strains was studied. Strains becoming resistant to gentamicin either by laboratory training or through an R-factor were more susceptible to the phagocytic and bactericidal function of the PMNs. These results may explain previous clinical and laboratory observations indicating that gentamicin-resistant strains are less virulent.
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001770:Blood Bactericidal Activity; D004352:Drug Resistance, Microbial; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D009504:Neutrophils / Q000276:immunology / Q000502:physiology*; D010587:Phagocytosis; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000276:immunology*
D000900:Anti-Bacterial Agents; D005839:Gentamicins