Comparison of the hemodynamic effects of Hexabrix and Renografin-76 following left ventriculography and coronary arteriography.
A crossover comparison of 41 patients studied by standard percutaneous transfemoral catheterization examined the electrocardiographic effects of Hexabrix and Renografin-76. Following both the right and left coronary angiograms, Renografin-76 caused significantly longer increases in the RR interval than did Hexabrix. Following left ventriculography, Renografin-76 shortened the RR interval more significantly than Hexabrix. Changes in aortic diastolic, systolic and mean pressures, as well as, cardiac index changes and systemic resistance following left ventriculograms were all much less using Hexabrix. Hemodynamic function was routinely affected less following the administration of Hexabrix as compared with Renografin-76. Both contrast agents provided good or excellent diagnostic studies. No observable difference in opacification was noted.
D000792:Angiography / Q000009:adverse effects; D002986:Clinical Trials as Topic; D003287:Contrast Media / Q000009:adverse effects*; D017023:Coronary Angiography; D003973:Diatrizoate / Q000009:adverse effects* / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000009:adverse effects*; D004338:Drug Combinations / Q000009:adverse effects; D006321:Heart / Q000000981:diagnostic imaging*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007463:Iodobenzoates / Q000009:adverse effects*; D007485:Ioxaglic Acid; D011897:Random Allocation; D014283:Triiodobenzoic Acids / Q000009:adverse effects*
D003287:Contrast Media; D004338:Drug Combinations; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; C027278:urovision; D007485:Ioxaglic Acid