[Experimental study of the antitumor activity of nitrosomethylurea, adriablastine and ftorafur on model gliomas with different growth rates].
A marked antitumor effect of the agents studied was demonstrated in experiments on three strains of gliomas of the brain of rats (two rapidly-growing and one slowly-growing tumor). Phthorafur increased the survival of the animals with one of the rapidly-growing tumors (strain No. 35) and often had a marked side effect. Adriablastin inhibited the development of rapidly-growing gliomas but was ineffective in experiments with slowly-growing glioma. NMU considerably increased the survival of the animals in all experiments but recovery was not encountered. In treatment with NMU, a cell population resistant to this agent occurred in the gliomas. A new glioma strain was obtained during the experiments; it was insensitive to therapeutic doses of NMU and differed in morphology from the initial highly-sensitive tumor (strain No. 2211). The prospects of using agents of the nitrosomethyl urea group in the chemotherapy of gliomas are discussed.
D000818:Animals; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004317:Doxorubicin / Q000627:therapeutic use*; D005260:Female; D005472:Fluorouracil / Q000031:analogs & derivatives*; D005910:Glioma / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008770:Methylnitrosourea / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009607:Nitrosourea Compounds / Q000627:therapeutic use*; D051381:Rats; D005641:Tegafur / Q000627:therapeutic use*
D009607:Nitrosourea Compounds; D005641:Tegafur; D008770:Methylnitrosourea; D004317:Doxorubicin; D005472:Fluorouracil
Eksperimental'noe issledovanie protivoopukholevoĭ aktivnosti nitrozometilmocheviny, adriablastina i ftorafura na modeli gliom s razlichnoĭ skorost'iu rosta.