Differential expression of the translocated and the untranslocated c-myc oncogene in Burkitt lymphoma.
Burkitt lymphoma cells carrying either a rearranged or unrearranged c-myc oncogene were examined with the use of probes from the 5' exon and for the second and third exon of the oncogene. The results indicate that the normal c-myc gene on chromosome 8 and the 5' noncoding and 3' coding segments of the c-myc oncogene separated by the chromosomal translocation are under different transcriptional control in the lymphoma cells. Burkitt lymphoma cells carrying a translocated but unrearranged c-myc oncogene express normal c-myc transcripts. In contrast, lymphoma cells carrying a c-myc gene rearranged head to head with the immunoglobulin constant mu region gene express c-myc transcripts lacking the normal untranslated leader.
D002051:Burkitt Lymphoma / Q000235:genetics*; D002901:Chromosomes, Human, 13-15; D002903:Chromosomes, Human, 19-20; D002906:Chromosomes, Human, 6-12 and X; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D009857:Oncogenes; D009876:Operon; D014158:Transcription, Genetic; D014178:Translocation, Genetic
D007143:Immunoglobulin Heavy Chains