Studies of autoimmunity in multiple sclerosis.
The central nervous system myelin unit (the myelin sheath and the supporting oligodendrocyte) may be damaged by a number of immune-mediated mechanisms involving cellular or humoral factors. In this review the following areas will be considered: the composition and properties of central nervous system myelin, the chemical and biological characteristics of oligodendrocytes, the participation of the central nervous system myelin unit in experimentally induced diseases, and a description and analysis of immunological abnormalities in humans with multiple sclerosis.
D000941:Antigens / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D002490:Central Nervous System / Q000276:immunology / Q000378:metabolism; D003711:Demyelinating Diseases / Q000276:immunology; D006801:Humans; D007154:Immune System Diseases / Q000150:complications; D007136:Immunoglobulins / Q000134:cerebrospinal fluid; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000150:complications / Q000276:immunology* / Q000473:pathology; D009186:Myelin Sheath / Q000276:immunology / Q000378:metabolism; D009836:Oligodendroglia / Q000276:immunology / Q000378:metabolism / Q000473:pathology
D000941:Antigens; D001323:Autoantibodies; D007136:Immunoglobulins