[Serotonin binding by various populations of peritoneal cells and blood leukocytes from intact and thymectomized mice].
Specific activity of 3H-serotonin binding with adhesive cells, as well as with T-lymphocyte enriched cells and B-lymphocytes, obtained from peritoneal excudate and blood leucocytes of CBA mice was determined. The highest affinity to amine was established in peritoneal T2 cells and adhesive blood cells. Results of studying the action of imipramin and blocators of some known serotonin receptors on amine binding with the investigated cells allow a conclusion on structural differences of serotonin-binding centres located on T-lymphocyte enriched cells and B-lymphocytes depending of their localization. The reduction of serotonin binding by immunocytes during ageing processes with animals (particularly tymectomized) was revealed, and this is supposed to be correlated with changes of immunological reactivity with ageing. It is supposed that serotonin participates in cooperative interactions of immunocytes in blood and peritoneal cavity.
D000375:Aging; D000818:Animals; D001202:Ascitic Fluid / Q000378:metabolism*; D001402:B-Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D002448:Cell Adhesion; D006854:Hydrocortisone / Q000494:pharmacology; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D051379:Mice; D012701:Serotonin / Q000378:metabolism*; D013601:T-Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D013934:Thymectomy; D013950:Thymus Gland / Q000502:physiology*; D014916:Whole-Body Irradiation
D012701:Serotonin; D006854:Hydrocortisone
Sviazyvanie serotonina raznymi populiatsiiami peritoneal'nykh kletok i leĭkotsitov krovi intaktnykh i timéktomirovannykh mysheĭ.