Inositol administration restores the sensitivity of liver cells formed during liver regeneration to alpha 1-adrenergic amines, vasopressin and angiotensin II.
Hepatocytes obtained from rats partially hepatectomized 72 h before experimentation are insensitive to alpha 1-adrenergic amines, vasopressin, angiotensin II and ionophore A23187. However, if inositol is administered to the rats 24 and 48 h after surgery, the above-mentioned hormones stimulate glycogenolysis, gluconeogenesis and ureogenesis in the newly formed hepatocytes. Furthermore, ionophore A23187 is able to stimulate glycogenolysis in these cells, the mechanism through which inositol produces this effect being unknown. A rôle for phosphatidylinositol is suggested.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D000001:Calcimycin / Q000494:pharmacology; D005260:Female; D005943:Gluconeogenesis / Q000187:drug effects; D007294:Inositol / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D008112:Liver Glycogen / Q000378:metabolism; D008115:Liver Regeneration; D051381:Rats; D011919:Rats, Inbred Strains; D013566:Sympathomimetics / Q000494:pharmacology*; D014508:Urea / Q000378:metabolism
D008112:Liver Glycogen; D013566:Sympathomimetics; D000804:Angiotensin II; D001127:Arginine Vasopressin; D000001:Calcimycin; D007294:Inositol; D014508:Urea