The conversion of sterigmatocystin to O-methylsterigmatocystin and aflatoxin B1 by a cell-free preparation.
A cell-free system derived from a versicolorin A-accumulating mutant of Aspergillus parasiticus was found to convert sterigmatocystin to both O-methylsterigmatocystin and aflatoxin B1. It is suggested that the similarity in the chromatographic properties of these two metabolites has caused erroneous conclusions to be made with regards to the biosynthesis of aflatoxin B1.
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000096:biosynthesis*; D001230:Aspergillus / Q000378:metabolism*; D002273:Carcinogens / Q000378:metabolism*; D002474:Cell-Free System; D005001:Ethionine / Q000378:metabolism; D007700:Kinetics; D012436:S-Adenosylmethionine / Q000378:metabolism; D013241:Sterigmatocystin / Q000031:analogs & derivatives / Q000096:biosynthesis* / Q000378:metabolism*; D014966:Xanthenes / Q000096:biosynthesis* / Q000378:metabolism*
D000348:Aflatoxins; D002273:Carcinogens; D014966:Xanthenes; D013241:Sterigmatocystin; C039904:O-methylsterigmatocystin; D012436:S-Adenosylmethionine; D016604:Aflatoxin B1; D005001:Ethionine