[Pharmacological characteristics of a new phenyl analog of piracetam--4-phenylpiracetam].
The central neurotropic effects of 4-phenylpyracetam, a new phenyl analog of pyracetam, were studied and compared with the effects of pyracetam, morpholene and 4-phenylpyrrolidone. 4-Phenylpyracetam was found to activate the operant behavior more powerfully, to remove psychodepressant effects of diazepam, to inhibit post-rotational nystagmus, and to prevent the development of retrograde amnesia. Unlike pyracetam, 4-phenylpyracetam exhibits a specific anticonvulsant action. When given in high doses, the compound under study produces psychodepressant effects.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004828:Epilepsies, Partial / Q000188:drug therapy; D006168:Guinea Pigs; D051379:Mice; D009025:Morpholines / Q000494:pharmacology; D009760:Nystagmus, Physiologic / Q000187:drug effects; D010889:Piracetam / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use / Q000633:toxicity; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats
D000927:Anticonvulsants; D009025:Morpholines; D011760:Pyrrolidinones; C002378:morfolep; C037917:4-phenylpiracetam; D010889:Piracetam
Farmakologicheskaia kharakteristika novogo fenil'nogo analoga piratsetama--4-fenilpiratsetama.