Structural changes required for activation of protein C are induced by Ca2+ binding to a high affinity site that does not contain gamma-carboxyglutamic acid.
D015055:1-Carboxyglutamic Acid / Q000502:physiology*; D000818:Animals; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism*; D002417:Cattle; D003956:Dialysis; D004492:Edetic Acid / Q000494:pharmacology; D004789:Enzyme Activation; D005971:Glutamates / Q000502:physiology*; D006023:Glycoproteins / Q000378:metabolism*; D007700:Kinetics; D008274:Magnesium / Q000494:pharmacology; D011486:Protein C; D013050:Spectrometry, Fluorescence; D013329:Structure-Activity Relationship
D005971:Glutamates; D006023:Glycoproteins; D011486:Protein C; D015055:1-Carboxyglutamic Acid; D004492:Edetic Acid; D008274:Magnesium; D002118:Calcium