Controlled tests of activity of ivermectin against natural infections of migratory large strongyles and other internal parasites of equids.
Four controlled tests (experiments A, B, C, and D) were conducted in naturally infected yearling equids to evaluate activity of ivermectin (0.2 mg/kg IM) against migrating Strongylus vulgaris and S edentatus in mesenteric arteries and ventral abdominal wall, respectively. Data were also obtained on activity against other internal parasites of the gastrointestinal tract and eyeworms. The type and number of equids in the experiments were as follows: experiment A-3 ponies, 2 treated and 1 non-treated; experiment B-4 mixed-bred horses, 2 treated and 2 nontreated; experiment C-5 mixed-bred horses, 3 treated and 2 nontreated; experiment D-4 mixed-bred horses, 2 treated and 2 nontreated. Intervals between treatment and necropsy were 35 days in experiment A, 52 to 53 days in experiment B, 38 to 41 days in experiment C, and 45 days in experiment D. Efficacious killing of retroperitoneal forms of S edentatus in the ventral abdominal wall was obtained in the 4 experiments. Only dead worms or fragments were recovered from treated animals, while living 4th-stage and/or 5th-stage S edentatus was present in nontreated equids in each test. A similar killing effect on S vulgaris in cranial mesenteric arteries was recorded in 2 experiments (B and D); only 1 dead 5th-stage worm was found in 1 of the treated yearlings in experiment B, whereas living 4th- and 5th-stages of S vulgaris were found in the nontreated controls in both experiments.(ABSTRACT TRUNCATED AT 250 WORDS)
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D002986:Clinical Trials as Topic / Q000662:veterinary; D005260:Female; D006373:Helminthiasis / Q000188:drug therapy / Q000469:parasitology; D006374:Helminthiasis, Animal; D006736:Horses; D007559:Ivermectin; D007783:Lactones / Q000627:therapeutic use*; D008297:Male; D008638:Mesenteric Arteries / Q000469:parasitology; D010270:Parasite Egg Count / Q000662:veterinary; D012187:Retroperitoneal Space / Q000469:parasitology; D013319:Strongyle Infections, Equine / Q000188:drug therapy* / Q000469:parasitology
D000871:Anthelmintics; D007783:Lactones; D007559:Ivermectin