An immunological study of germinal centres in four ophthalmic immunocytomas.
Four ophthalmic lymphoplasmacytic/lymphoplasmacytoid (LP) immunocytomas with germinal centres were reviewed histologically and studied immunologically by means of the peroxidase-antiperoxidase (PAP) method. In two cases a histological diagnosis of LP immunocytoma was made, while in the other two cases a non-Hodgkin's lymphoma could not be histologically differentiated with certainty from a pseudolymphoma or reactive process. Immunological analysis confirmed the diagnosis in the former two cases and led in one of the latter also to a diagnosis of LP immunocytoma. In the fourth case the development of LP immunocytoma out of a pseudolymphoma could be demonstrated. In the four LP immunocytomas the germinal centres showed a monoclonal pattern of immunoglobulin in one case, a polyclonal pattern in one case and a negative reaction in two cases. The role of germinal centres in relation to the development of LP immunocytoma is discussed.
D000368:Aged; D005134:Eye Neoplasms / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007136:Immunoglobulins / Q000032:analysis; D008223:Lymphoma / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged
D007136:Immunoglobulins