Biosynthesis of Bacillus licheniformis penicillinase in Escherichia coli and in Bacillus subtilis.
Modified prepenicillinase was accumulated in both Escherichia coli and Bacillus subtilis treated with globomycin. Although the inhibitions of processings of prepenicillinase and prolipoprotein by globomycin in E. coli are qualitatively similar, they differ in the degree of inhibition at given concentrations of globomycin. The processing of prepenicillinase proceeds much more rapidly in E. coli than in B. subtilis.
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001407:Bacillus / Q000201:enzymology* / Q000235:genetics; D001412:Bacillus subtilis / Q000201:enzymology / Q000235:genetics*; D001425:Bacterial Outer Membrane Proteins; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics*; D029968:Escherichia coli Proteins; D007700:Kinetics; D008074:Lipoproteins / Q000235:genetics; D010405:Penicillinase / Q000235:genetics* / Q000302:isolation & purification; D010455:Peptides / Q000494:pharmacology; D011498:Protein Precursors / Q000235:genetics; D011499:Protein Processing, Post-Translational / Q000187:drug effects
D000900:Anti-Bacterial Agents; D001425:Bacterial Outer Membrane Proteins; D029968:Escherichia coli Proteins; D008074:Lipoproteins; C099932:Lpp protein, E coli; D010455:Peptides; D011498:Protein Precursors; C017339:globomycin; D010405:Penicillinase