Similar liver function abnormalities occur in patients receiving glucose-based and lipid-based parenteral nutrition.
Biochemical and histopathological evidence of hepatic dysfunction has been associated with the use of glucose-based total parenteral nutrition (TPN). In the present study liver indices, SGOT, SGPT, alkaline phosphatase, and bilirubin, were analyzed retrospectively during the course of total parenteral nutrition in 40 patients; 15 patients received a glucose-based system and 25 received a lipid-based system. Transient elevations in at least one of the measured parameters were found in a majority of patients receiving either system. These data confirm previous reports of liver function test abnormalities in patients receiving glucose-based total parentual nutrition. However, in contrast to results from prior studies, these derangements also were observed during the administration of a nutritional support system using lipids as the primary source of calories.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D008099:Liver / Q000503:physiopathology*; D008111:Liver Function Tests; D008875:Middle Aged; D010288:Parenteral Nutrition / Q000009:adverse effects*; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D012189:Retrospective Studies
D005217:Fat Emulsions, Intravenous; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D005947:Glucose