Changes in cardiac output and systemic arterial pressure after insertion of acrylic cement during trimetaphan, sodium nitroprusside and glycerol trinitrate-induced hypotension. A comparison with changes during normotension.
The effects of implantation of acrylic monomer on the cardiovascular response were studied in 37 patients undergoing hip arthroplasty and receiving high-dose fentanyl anaesthesia, under normotensive conditions or during hypotension induced by trimetaphan (TMP), sodium nitroprusside or nitroglycerine. Heart rate, mean arterial pressure (MAP), the ventricular stroke volume (SV) and the cardiac output (CO) were monitored before, and at 1, 2, 4, 6, and 8-min intervals after the insertion of the acrylic cement into the acetabulum or the neck of femur. There was a moderate decrease in MAP after insertion into the acetabulum under normotensive conditions and TMP-induced hypotension, while the reduction in pressure was significant after the cement's application in the femur. Heart rate did not change on insertion of the monomer in any of the patients. Moderate decreases in SV and CO were observed during normotension or TMP-induced hypotension. There were no significant changes in the cardiovascular haemodynamics on the insertion of the acrylic material under hypotension induced by nitroprusside or nitroglycerine.
D000077:Acetabulum / Q000601:surgery; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D001843:Bone Cements / Q000494:pharmacology*; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D005269:Femur / Q000601:surgery; D006439:Hemodynamics / Q000187:drug effects*; D006622:Hip Prosthesis; D006801:Humans; D007023:Hypotension, Controlled; D020366:Methylmethacrylate; D008768:Methylmethacrylates / Q000494:pharmacology*; D005996:Nitroglycerin; D009599:Nitroprusside; D013997:Time Factors; D014294:Trimethaphan
D001843:Bone Cements; D008768:Methylmethacrylates; D009599:Nitroprusside; D020366:Methylmethacrylate; D014294:Trimethaphan; D005996:Nitroglycerin