Neonatal treatment with 6-OH dopamine and the elimination of polyneuronal innervation of skeletal muscle in the rat.
The polyneuronal innervation of skeletal muscles of newborn rats was eliminated completely in spite of virtually complete destruction of the sympathetic nervous system with 6-OH dopamine (6-OHDA). There was, however, a moderate delay in the elimination of redundant nerve terminals which is probably a secondary effect of the treatment.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D006892:Hydroxydopamines / Q000494:pharmacology*; D007498:Iris / Q000294:innervation; D009045:Motor Endplate / Q000187:drug effects; D009132:Muscles / Q000294:innervation*; D009469:Neuromuscular Junction / Q000187:drug effects; D016627:Oxidopamine; D051381:Rats; D011920:Rats, Inbred WF; D013564:Sympathetic Nervous System / Q000187:drug effects*
D006892:Hydroxydopamines; D016627:Oxidopamine