Stimulation of insulin secretion by peptides analogous to the C-terminal tetrapeptide amide of cholecystokinin.
Two tetrapeptides, Glp-Met-Asp-Phe-NH2 (I) and Pro-Met-Asp-Phe-NH2 (II), analogous to the C-terminal tetrapeptide amide of cholecystokinin (CCK-4) have been synthesized and their effect on the release of insulin from the isolated Langerhans islets of rat pancreas compared with that of synthetic CCK-4. Both the new congeners exhibited significant insulin-releasing activity at 10(-8) M and 10(-6) M concentrations, suggesting that the biological activity is retained when the N-terminal Trp residue of CCK-4 is replaced by Glp or Pro.
D000818:Animals; D002096:C-Peptide / Q000494:pharmacology*; D002766:Cholecystokinin / Q000494:pharmacology*; D005755:Gastrins / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D013268:Stimulation, Chemical; D013758:Tetragastrin / Q000494:pharmacology*
D002096:C-Peptide; D005755:Gastrins; D007328:Insulin; D013758:Tetragastrin; D002766:Cholecystokinin