[Pathogenesis and immunotherapy of insulin-dependent (type I) diabetes mellitus].
The association of insulin-dependent (type I) diabetes mellitus with HLA-DR3 and DR4 and with several epidemiological, virological, immunological, and clinical data suggests a heterogenous pathogenesis. the initial lesion in most cases is a virologically induced autoimmune process. It is only rarely that insulin-dependent diabetes results from a pure viral infection or as part of polyendocrine autoimmune deficiencies. The knowledge of the genetical risk factors and of disease-specific humoral and cellular immune deviations exhibits possibilities of successful intervention by means of immunotherapy.
D001327:Autoimmune Diseases / Q000276:immunology; D003920:Diabetes Mellitus / Q000209:etiology / Q000235:genetics / Q000276:immunology* / Q000628:therapy; D005802:Genes, MHC Class II; D015803:HLA-DR3 Antigen; D015804:HLA-DR4 Antigen; D006801:Humans; D007167:Immunotherapy; D007328:Insulin / Q000502:physiology; D014777:Virus Diseases / Q000276:immunology
D015803:HLA-DR3 Antigen; D015804:HLA-DR4 Antigen; D007328:Insulin
Zur Pathogenese und Immuntherapie des insulinbedürftigen (Typ I) Diabetes mellitus.