LHRH self-priming in the male: effect of multiple priming injections in the immature rat.
Pubertal and young adult male rats show a self-priming effect of LHRH on LH secretion; immature male rats do not. To determine whether the extent of endogenous priming plays a role in this difference, immature male rats were examined for a self-priming effect after pretreatment with three, four, five, or six injections of LHRH. Compared to saline-primed controls, animals receiving LHRH pretreatment released similar amounts of LH in response to a challenge injection of LHRH regardless of the number of priming injections. These results support the view that the induction of the self-priming effect at puberty is not the result of changes in hypothalamic function.
D000818:Animals; D007987:Gonadotropin-Releasing Hormone / Q000502:physiology*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D051381:Rats; D012741:Sexual Maturation
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone