[Differences in the effects of 6-hydroxydopamine on rat learning with intraventricular and local administration into nuclei of the brain catecholaminergic system].
Correlation of the effects obtained with different routes of 6-hydroxydopamine (6-OHDA) administration to the rat brain on the training has disclosed that the drug injection to the lateral ventricles of the brain markedly interferes with the animals' learning both on food and painful reinforcement. Administration of 6-OHDA to the area where noradrenergic neurons have accumulated (A6) is followed by the embarrassment of active avoidance behavior and facilitation of the training on food reinforcement. Local administration of 6-OHDA to the area where dopaminergic neurons have accumulated (A9) decreases the reliability of the formed habits whatever the emotional sign of the reinforcing stimulant.
D000818:Animals; D002552:Cerebral Ventricles / Q000502:physiology*; D006892:Hydroxydopamines / Q000008:administration & dosage; D007276:Injections, Intraventricular; D007858:Learning / Q000502:physiology*; D008125:Locus Coeruleus / Q000187:drug effects / Q000502:physiology*; D008297:Male; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*
D006892:Hydroxydopamines; D016627:Oxidopamine
Razlichiia éffektov 6-gidroksidofamina na obuchenie krys pri vnutrizheludochkovom i lokal'nom ego vvedenii v otdel'nye iadra katekholaminergicheskoĭ sistemy mozga.