Interrelationships between the chemical structure of prostanoids and prostacyclins and their cytoprotective effects on the ethanol-induced gastric mucosal damage in rats (a comparative experimental study).
Structurally modified prostaglandins have been synthesized, PGF2 alpha skeleton being substituted at the 13 and 17 position. The prostacyclin analogues were modified at the 3,13 or 17 positions of the prostacyclin skeleton. The effect of these compounds was studied on the development of gastric mucosal damage produced by the intragastric administration of 96% ethanol. The different compounds were given intraperitoneally 30 min before the administration of ethanol. The number and severity of gastric mucosal lesions (ulcers) were recorded without and with the use of different compounds. The prostanoids and prostacyclin analogues were given in doses of 1, 5, 25 or 126 micrograms/kg. Among the tested compounds several fairly active molecules could be found. The significance and practical usefulness of these modifications of prostaglandins and prostacyclins are discussed with special respect to the stereochemistry of molecules.
D000818:Animals; D015237:Dinoprost; D004305:Dose-Response Relationship, Drug; D011464:Epoprostenol / Q000494:pharmacology*; D000431:Ethanol / Q000633:toxicity*; D005753:Gastric Mucosa / Q000187:drug effects*; D011460:Prostaglandins F / Q000494:pharmacology; D011465:Prostaglandins, Synthetic / Q000494:pharmacology*; D051381:Rats; D013276:Stomach Ulcer / Q000517:prevention & control*; D013329:Structure-Activity Relationship
D011460:Prostaglandins F; D011465:Prostaglandins, Synthetic; D000431:Ethanol; D015237:Dinoprost; D011464:Epoprostenol