[Effect of immunoglobulin and antibiotic in E. coli infection of malnourished mice].
Malnourished mice, which exert a greater susceptibility to E.coli induced intraperitoneal infection than standard fed animals, cannot be protected by application of immunoglobulin (2 X 10(5) cells/animal). If, however, an antibiotic (mezlocillin, 500 mg/kg s.c.) is given shortly after infection, the surviving rate increases dramatically to 42%. This effect is enhanced to 63% survival, if the infected animals receive an additional dose of immunoglobulin.
D000818:Animals; D004044:Dietary Proteins / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004927:Escherichia coli Infections / Q000401:mortality / Q000517:prevention & control*; D005260:Female; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008802:Mezlocillin / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D008815:Mice, Inbred Strains
D004044:Dietary Proteins; D007136:Immunoglobulins; D008802:Mezlocillin
Der Effekt von Immunglobulin und Antibiotikum bei E.coli-Infektion mangelernährter Mäuse.