Electrolyte metabolism in patients with periodic affective disorders during treatment with rubidium.
Five patients suffering from periodic affective disorders with short mood-cycles were treated with rubidium chloride, producing peak erythrocyte concentrations between 9 and 13 mmol/l. Loading with rubidium was associated with decreased total body potassium, but red-cell potassium was unchanged. Regular mood-cycling was disturbed, together with the associated body-weight changes. There was a slight extracellular "metabolic" acidosis. Electrolyte concentrations fluctuate abnormally in these patients, and two muscle biopsy specimens had very low potassium contents.
D000341:Affective Disorders, Psychotic / Q000188:drug therapy / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects; D004573:Electrolytes / Q000378:metabolism*; D004644:Emotions / Q000187:drug effects; D005260:Female; D006801:Humans; D007700:Kinetics; D009132:Muscles / Q000378:metabolism; D010507:Periodicity; D012413:Rubidium / Q000627:therapeutic use*; D012463:Saliva / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000187:drug effects
D004573:Electrolytes; D012413:Rubidium