[Carcinogenesis, embryogenesis and aging from the view point of the assessment of cell proliferation and differentiation as a stochastic process].
An approach to cell proliferation and differentiation as to stochastic processes is described. The rate constants of cell population transitions to subsequent epigenetic states are interpreted as indicating instability of initial states. The duration of embryogenesis, the rate of loss of the ability to proliferation (a result of final differentiation) by the initial cell cultures, the error accumulation rate in the genetic cell apparatus (including both the genome itself and its interactions with the chromatin components) which determines the rate of ageing and the rate of the tumour incidence rise in particular, are all connected via the level of instability of the epigenetic states of cells. It is supposed that the differentiation mechanism of multicellular organisms originated from mechanisms of intragenome recombinational rearrangements of unicellular ones. A hypothetic scheme for basic processes occurring during cell differentiation is proposed accounting for the dual character of oncogenes necessary for differentiation but able to block it under definite conditions.
D000375:Aging; D000818:Animals; D002453:Cell Cycle; D002454:Cell Differentiation; D002455:Cell Division; D002470:Cell Survival; D002471:Cell Transformation, Neoplastic; D004622:Embryo, Mammalian / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D008954:Models, Biological; D011336:Probability; D013269:Stochastic Processes
Kantserogenez, émbriogenez i starenie s tochki zreniia otsenki proliferatsii i differentsirovki kletok kak stokhasticheskikh protsessov.