The influence of age on lithium efficacy and side-effects in out-patients.
One hundred and sixty-six unipolar and bipolar out-patients (21-78 years) on long-term lithium treatment were studied on a prospective basis. Although there was a possible tendency for manic attacks to increase in prevalence and severity with age, it was difficult to demonstrate a general age-related decline in lithium efficacy. There was a tendency for the prevalence and severity of fine hand tremor to increase with age. This was not seen with polydipsia/polyuria, the other typical lithium side-effect.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001714:Bipolar Disorder / Q000188:drug therapy*; D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008094:Lithium / Q000009:adverse effects / Q000627:therapeutic use*; D016651:Lithium Carbonate; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D011141:Polyuria / Q000139:chemically induced; D011446:Prospective Studies; D014202:Tremor / Q000139:chemically induced
D016651:Lithium Carbonate; D008094:Lithium