Oral treatment of hemophilia A using traditional kanpo medicine, Huang-lien-chieh-tu-tang (plant extract).
Huang-lien-chieh-tu-tang (HLCT) extract was given orally to a patient with severe hemophilia A. The plasma concentration of factor VIII rose from less than 1 to 41% 1 h after oral administration of HLCT extract. APTT also decreased from 102.0 to 70.9 s. In vitro experiments, HLCT showed factor VIII, IX and X biological activity at concentrations around 0.08%. There was no factor-VIII-antigen-related activity in HLCT.
D000284:Administration, Oral; D000328:Adult; D000941:Antigens / Q000032:analysis; D001780:Blood Coagulation Tests; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal; D005164:Factor IX / Q000032:analysis; D005167:Factor VII / Q000032:analysis / Q000276:immunology; D005169:Factor VIII / Q000032:analysis; D005260:Female; D006467:Hemophilia A / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D066298:In Vitro Techniques; D007564:Japan; D008297:Male; D008516:Medicine, Chinese Traditional; D008518:Medicine, East Asian Traditional; D010936:Plant Extracts / Q000008:administration & dosage*; D010946:Plants, Medicinal
D000941:Antigens; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; C031500:factor VII related antigen; C045607:huang-lien-chieh-tu-tang; D005167:Factor VII; D005169:Factor VIII; D005164:Factor IX