Clindamycin and its action on the susceptibility of pathogenic bacteria to phagocytosis.
The role of various surface virulence factors in bacterial resistance to opsonophagocytosis has been investigated in relation to the effect of clindamycin at concentrations below those which inhibit growth (sub-MIC). In each case studied (Streptococcus pyogenes, Staphylococcus aureus and Bacteroides fragilis) contact with the drug under these conditions potentiated complement-mediated opsonization of the bacterial cells resulting in a greater and more rapid deposition of C3 as C3b on the cell surface. Several other features of the phagocytic process were enhanced in consequence.
D000942:Antigens, Bacterial; D001419:Bacteria / Q000187:drug effects*; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins / Q000096:biosynthesis; D001441:Bacteroides fragilis / Q000187:drug effects / Q000378:metabolism; D002352:Carrier Proteins; D002981:Clindamycin / Q000494:pharmacology* / Q000627:therapeutic use; D006801:Humans; D009895:Opsonin Proteins; D010587:Phagocytosis / Q000187:drug effects*; D013205:Staphylococcal Protein A / Q000096:biosynthesis; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism; D013291:Streptococcus / Q000187:drug effects / Q000378:metabolism; D013297:Streptococcus pyogenes / Q000187:drug effects
D000942:Antigens, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D002352:Carrier Proteins; D009895:Opsonin Proteins; D013205:Staphylococcal Protein A; C014689:streptococcal M protein; D002981:Clindamycin