[Unscheduled synthesis induced by thiophosphamide in human lymphocytes].
An unscheduled DNA synthesis in human nonreplicative lymphocytes is shown to follow cell exposure to thiophosphamide at a dose level of 1-10 microgram/ml. Incorporation of 3H-thymidine in the absence of the mutagen is probably due to spontaneous reparative processes. Significant variations are found of spontaneous and thio-phosphamide-induced levels of a reparative DNA synthesis in normal individuals.
D004247:DNA / Q000096:biosynthesis*; D004260:DNA Repair / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D013852:Thiotepa / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014316:Tritium
D014316:Tritium; D004247:DNA; D013852:Thiotepa; D013936:Thymidine
Vneplanovyĭ sintez, indutsiruemyĭ tiofosfamidom v limfotsitakh cheloveka.