Histopathologic effects of transarterial bucrylate occlusion of intracerebral arteries in mongrel dogs.
Bucrylate was injected directly into the cerebral cortical arteries of mongrel dogs. Preparations for light and electron microscopy were obtained from 5 min to 5 months after the introduction of the polymer. A mixed pattern of damage to arterial endothelium was seen, including electron microscopic documentation of stripping away of the endothelium. Acute effects include a subocclusive thrombogenic matrix, which causes partial or complete thrombosis. The long-term reactions are those of a chronic inflammatory response to a foreign body.
D000818:Animals; D002545:Brain Ischemia / Q000139:chemically induced; D002015:Bucrylate / Q000009:adverse effects*; D002536:Cerebral Arteries / Q000187:drug effects*; D003487:Cyanoacrylates / Q000009:adverse effects*; D004285:Dogs; D004727:Endothelium / Q000187:drug effects; D002542:Intracranial Embolism and Thrombosis / Q000139:chemically induced; D008854:Microscopy, Electron; D009131:Muscle, Smooth, Vascular / Q000187:drug effects
D003487:Cyanoacrylates; D002015:Bucrylate