[Metabolism and pharmacokinetics of methoxy-9-ellipticine and its principal metabolite, hydroxy-9-ellipticine].
The biliary and urinary excretion of 9-methoxyellipticine in Rats yield the 0-demethylated metabolite 9-hydroxyellipticine, partly present as the glucuronide. Whole blood kinetics of 9-methoxyellipticine in Rabbits following a single i.v. administration is extremely fast, but is deeply modified after repeated dosage.
D000470:Alkaloids / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism*; D004611:Ellipticines / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D000470:Alkaloids; D000970:Antineoplastic Agents; D004611:Ellipticines; C008009:9-hydroxyellipticine; C001729:9-methoxyellipticine
Métabolisme et pharmacocinétique de la méthoxy-9-ellipticine et son métabolite principal, l'hydroxy-9-ellipticine.