Lithium and carbamazepine interaction: possible neurotoxicity.
A case is described of a 22-year-old woman with bipolar affective disorder who developed severe neurotoxic symptoms when treated with a combined regimen of lithium carbonate and carbamazepine in therapeutic doses. An open A-B-C-B trial of the two medications separately and concurrently implicated a synergistic interaction between the two.
D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy; D002220:Carbamazepine / Q000009:adverse effects* / Q000494:pharmacology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008094:Lithium / Q000009:adverse effects* / Q000494:pharmacology; D016651:Lithium Carbonate; D009422:Nervous System Diseases / Q000139:chemically induced*
D016651:Lithium Carbonate; D002220:Carbamazepine; D008094:Lithium