Specific effect of dietary saturated fat on rat aortic 6-keto-PGF1 alpha synthesis.
The effect of dietary lard and corn oil-supplementation on rat aortic 6-keto-PGF1 alpha synthesis from both exogenous and endogenous arachidonic acid was investigated. Only lard-supplementation resulted in any change when compared to rats fed normal chow. Lard-supplementation resulted in both a significant increase in the conversion of exogenous arachidonic acid to 6-keto-PGF1 alpha and a significant decrease in the ratio of linoleate to arachidonate in aortic phospholipids. Basal aortic synthesis of 6-keto-PGF1 alpha from endogenous arachidonic acid was not different for any group. We conclude that at least for the aortic conversion of exogenous arachidonic acid to 6-keto-PGF1 alpha the level of inhibitor linoleic acid in tissue phospholipids may be important.
D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis*; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism*; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D003314:Corn Oil; D004041:Dietary Fats / Q000378:metabolism / Q000494:pharmacology*; D005227:Fatty Acids / Q000494:pharmacology; D008297:Male; D009821:Oils; D010743:Phospholipids / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
D001095:Arachidonic Acids; D004041:Dietary Fats; D005227:Fatty Acids; D009821:Oils; D010743:Phospholipids; D016718:Arachidonic Acid; D015121:6-Ketoprostaglandin F1 alpha; D003314:Corn Oil; C029310:lard