Effect of cyclooxygenase inhibition on platelet-vessel wall interaction.
Prostaglandins play an important role in the platelet-vessel wall interaction. Acetylsalicylic acid inhibits the cyclooxygenase activity within the vessel wall. Continuous superfusion with acetylsalicylic acid induces a rapid, but evanescent decrease in thromboformation. The trigger mechanism involved could be related to the ratio of cyclic endoperoxides (PGG2 and PGH2) versus prostacyclin (PGI2).
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D016861:Cyclooxygenase Inhibitors; D011464:Epoprostenol / Q000378:metabolism; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects* / Q000378:metabolism; D011449:Prostaglandin Endoperoxides / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013927:Thrombosis / Q000209:etiology / Q000378:metabolism; D013997:Time Factors
D016861:Cyclooxygenase Inhibitors; D011449:Prostaglandin Endoperoxides; D011464:Epoprostenol; D001241:Aspirin