[Correlation between maternal glycohemoglobin values and insulin secretion in children of diabetic mothers].
Monthly determination of glycohaemoglobins from the 5th month until delivery were determined in a group of diabetic pregnant women, and insuline and peptide-C levels were measured in their newborns. Women with pathological babies had higher glycohaemoglobin values at the end of gestation (8.92 +/- 1.9) than those with normal babies (6.47 +/- 1.02) and those in control group (6.37 +/- 0.76). The number of abnormal glycohaemoglobin levels in successive gestational months was significantly higher in the group with neonatal pathology. The peptide-C and insuline concentrations were higher in pathological newborn (6.37 +/- 9,3 ng/ml and 80 +/- 102 mcU/ml) than in normal babies (0.65 +/- +/- 0.53 ng/ml and 16.5 +/- 10.6 mcU/ml). A correlation between peptide-C concentration in newborns and levels of glycohaemoglobins in their mothers (p less than 0.05) was found. Authors conclude that monthly determination of glycohaemoglobin during gestation is a good index of metabolic control in the mother, and consequently useful in order to predict fetal pathology.
D002096:C-Peptide / Q000097:blood*; D003920:Diabetes Mellitus / Q000235:genetics; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood*; D007328:Insulin / Q000097:blood*; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood*
D002096:C-Peptide; D006442:Glycated Hemoglobin; D007328:Insulin
Correlación entre las cifras de glicohemoglobinas maternas y la secrección insulínica en los hijos de madre diabética.