Inhibition of aging changes by lyophilized Streptococcus faecalis in diet.
Effects of dietary Streptococcus faecalis (SF) on aging were evaluated using 1-week, 6-month, and 27-month-old Wistar and SHR rats. SF was lyophilized and added to commercial pellets at 1%. SF inhibited hypertension in aging SHR. SF inhibited aging-related changes in a wide variety of tissues. These changes were a disarray of hepatic cords, portal fibrosis; calcification of cartilage matrix, dominance of chondroitin sulfate B, and keratosulfate over chondroitin sulfates A and C; aortic endothelial damage, segmental thickening, calcification, and chondroid cells in the intima; atrophy of epidermis and appendages, and increase in amorphous dermal matrix; waxy degeneration and atrophy of psoas muscles; increase in lipoperoxides in the serum, liver, and brain; and reduction of cyclic AMP and GMP in the serum. Histological changes of the xyphoid cartilage, aorta, mesenteric artery, liver, dorsal skin, and psoas muscles in 27-month-old SF rats were much less severe than those in controls.
D000375:Aging; D000818:Animals; D001011:Aorta / Q000473:pathology; D001428:Bacterial Vaccines / Q000494:pharmacology*; D001921:Brain / Q000473:pathology; D002118:Calcium / Q000032:analysis; D002356:Cartilage / Q000032:analysis / Q000473:pathology; D013293:Enterococcus faecalis / Q000276:immunology*; D005260:Female; D006909:Hydroxyproline / Q000097:blood; D008099:Liver / Q000473:pathology; D008297:Male; D008930:Mitochondria, Liver / Q000473:pathology; D009133:Muscular Atrophy / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000473:pathology; D013599:Systole
D001428:Bacterial Vaccines; D006909:Hydroxyproline; D002118:Calcium