Regulation of MHC class II invariant chain expression: induction of synthesis in human and murine plasmocytoma cells by arresting replication.
The expression of the H2 Ia-associated invariant chain (Ii) has been determined by pulse labeling cells with [35S]methionine and resolving the proteins. Expression is maximal in noncycling peripheral B lymphocytes and is reduced upon maturation of B lymphocytes to plasma cells. B cell-derived cell lines behave correspondingly: IgM+ non-secretor cell lines synthesize Ii while plasmocytoma cells do not. Pre-B cell lines are also negative. In all Ii-negative cell lines, the synthesis of Ii is selectively induced by treating the cells with inhibitors of replication.
D000818:Animals; D001402:B-Lymphocytes / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006183:H-2 Antigens / Q000096:biosynthesis* / Q000145:classification; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D006801:Humans; D008562:Membrane Glycoproteins; D051379:Mice; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D010954:Plasmacytoma / Q000276:immunology / Q000378:metabolism*; D014176:Protein Biosynthesis; D011506:Proteins
D006183:H-2 Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D008562:Membrane Glycoproteins; D008937:Mitomycins; D011506:Proteins; C035572:XM1 protein, human; D016685:Mitomycin