[Therapeutic use of synthetic Gn-RH-Dirigestran in disorders of the reproductive cycle in cows from low-fertility herds].
Synthetic Gn-RH-Dirigestran Spofa was used for the treatment of 121 cows with functional ovarial disorders. Out of this total number, 41 cows showed no postpartal and no post-service symptoms of oestrus, 59 returned to oestrus with irregular cycles, and 21 cows showed an irregular course of oestrus. The treatment was made in herds with a low conception rate (32-37% conceptions after the first insemination, service period 108 to 142 days). On the whole, 80.1% of the treated cows got in calf, 53.7% conceived after the first insemination. The average time from treatment to successful insemination was 39 days. The treatment was started 148 days from parturition, on an average. The average insemination index of the treated cows was 1.44. As to cows out of heat, 70.7% got in calf on the whole and 51.2% after the first insemination, the therapeutic service period (TSP) being 44 days. Out of the cows returning to oestrus with an irregular cycle, 84.7% got in calf and 52.5% got in calf after the first insemination with the TSP of 37 days, and the cows with irregular cycle the conception was recorded in 85.7% (61.9% after the first insemination with the average TSP of 35 days). On the whole, 82% of treated cows showed clearly visible symptoms of oestrus after the application of Dirigestran. The pregnancy of the whole set (121 treated cows) was higher by 15 to 21% after the first insemination and by 41 to 49% after all inseminations, as compared with the pregnancy of normally inseminated cows in these herds. The results show that the treatment of the functional disorders of ovaries is also practicable in cows in herds with a decreased fertility if this treatment is not impaired by spermiotoxicity or embryotoxicity owing to the effects of inadequate secretions of sexual organs caused by incorrect nutrition or infections.
D000780:Anestrus; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D004973:Estrus Synchronization; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use*; D006728:Hormones / Q000627:therapeutic use*; D010049:Ovarian Diseases / Q000188:drug therapy / Q000662:veterinary*; D011247:Pregnancy
D006728:Hormones; D007987:Gonadotropin-Releasing Hormone
Terapeutické pouzití syntetického Gn-RH-Dirigestranu pri poruchách reprodukcního cyklu krav v chovech s nízkou plodností.