Effects of gabexate mesilate on the reactions of lipid metabolism in endotoxic shock.
Endotoxic shock was induced in rabbits of either sex by IV injection of 50 micrograms/kg endotoxin (ET) extracted from E coli O-55 by Boivin's method. A polyvinyl catheter was introduced into the superior vena cava under local anesthesia 1 day prior to the experiments. We observed a rise of plasma-free fatty acids (FFA) from an initial mean value of 190 muEq/liter to a level of 290 muEq/liter within 6 h after injection of endotoxin. The increase of FFA was followed by a rise of plasma triglycerides (TG) and an increase of very low-density lipoproteins (VLDL), beginning 1-2 h later. The rise of FFA and the following increase of TG and VLDL were significantly reduced by infusion of 14 micrograms/kg X min gabexate mesilate (GM). Our results indicate that GM--in addition to its well-known proteinase inhibitory action--effects fatty acid metabolism.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000378:metabolism; D004731:Endotoxins / Q000008:administration & dosage; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D016670:Gabexate; D005990:Glycerol / Q000097:blood; D006146:Guanidines / Q000008:administration & dosage*; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D011817:Rabbits; D012772:Shock, Septic / Q000097:blood* / Q000209:etiology; D014280:Triglycerides / Q000097:blood
D004731:Endotoxins; D005230:Fatty Acids, Nonesterified; D006146:Guanidines; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D016670:Gabexate; D005990:Glycerol