Hemagglutination treponemal test for syphilis.
Sera from 290 hospital patients were tested to compare the sensitivity, specificity, and reproducibility of the hemagglutination treponemal test for syphilis (HATTS) with the fluorescent treponemal antibody absorption test (FTA-ABS). Complete agreement was obtained between the methods when 142 syphilitic sera from patients with various stages of syphilis were tested. By using clinical histories, the specificity with 148 nonsyphilitic sera was determined to be 100% for the HATTS and 96.6% (143 of 148) for the FTA-ABS. Satisfactory reproducibility was obtained with both methods. Compared with the FTA-ABS, the HATTS was more specific, easier, and more economical to perform. We therefore recommend the HATTS as a suitable alternative to the FTA-ABS.
D003362:Cost-Benefit Analysis; D006386:Hemagglutination Tests / Q000191:economics / Q000379:methods; D006801:Humans; D007158:Immunologic Techniques / Q000191:economics; D013588:Syphilis Serodiagnosis / Q000191:economics / Q000379:methods*; D014210:Treponema pallidum / Q000276:immunology