Betalactamase-producing microorganisms in recurrent tonsillitis.
In 73% of 167 patients with recurrent tonsillitis, colonization with betalactamase-producing microorganisms was found. Betastreptococci group A were recovered in 6% of the patients and group C and G streptococci in 23%. Other microorganisms found were Staphylococcus aureus in 42%, Haemophilus species in 52%, bacteroides species in 80% and fusobacteria in 40%. Ninety-eight per cent of Staph. aureus, 60% of bacteroides species and 10% of fusobacteria were betalactamase-producing. Phenoxymethylpenicillin (1 g twice a day for ten days) diminished 50% of group A, C and G streptococci. No other microorganisms were affected by this antibiotic. Clindamycin (0.15 g four times a day for ten days) eradicated Staph. aureus, group A, C and G streptococci, bacteroides and fusobacteria. Haemophilus species were not affected by clindamycin. Tinidazole (1 g once a day for 10 days) diminished bacteroides and fusobacteria. Aerobic microorganisms, Staph. aureus, streptococci and Haemophilus, were not affected by tinidazole.
D000293:Adolescent; D000328:Adult; D001419:Bacteria / Q000187:drug effects* / Q000201:enzymology; D001424:Bacterial Infections / Q000188:drug therapy / Q000382:microbiology*; D002981:Clindamycin / Q000494:pharmacology*; D006801:Humans; D009593:Nitroimidazoles / Q000494:pharmacology*; D010403:Penicillin Resistance; D010404:Penicillin V / Q000494:pharmacology*; D012008:Recurrence; D014011:Tinidazole / Q000494:pharmacology*; D014069:Tonsillitis / Q000188:drug therapy / Q000382:microbiology*; D001618:beta-Lactamases / Q000096:biosynthesis*
D009593:Nitroimidazoles; D014011:Tinidazole; D002981:Clindamycin; D001618:beta-Lactamases; D010404:Penicillin V