[GTP-cyclohydrolases of microorganisms and their role in metabolism].
The properties, regularities of biosynthesis and biochemical functions are considered of GTP-cyclohydrolases of microorganisms. The existence of two groups of these enzymes is established. The first group enzymes convert GTP into 7,8-dihydroneopterin-triphosphate and formiate. They participate in biosynthesis of tetrahydrofolic acid, tetrahydrobiopterin, molybdenic cofactor, pyrrolopyrimidine antibiotics and in a series of pigments. Representatives of the second group of cyclohydrolases convert GTP into 2,5-diamino-4-oxy-6-ribosylaminopyrimidine-5'-phosphate, formiate and pyrophosphate. They catalyze the first stages of formation of 6,7-dimethyl-8-ribityllumazine, flavins and their derivatives, toxoflavin (azapteridine antibiotics). The regulation of biosynthesis and activity of GTP-cyclohydrolases is studied only for individual enzymes of this group.
D000619:Aminohydrolases / Q000378:metabolism*; D000900:Anti-Bacterial Agents / Q000096:biosynthesis; D001419:Bacteria / Q000201:enzymology* / Q000378:metabolism; D001665:Binding Sites; D055598:Chemical Phenomena; D002621:Chemistry; D004734:Energy Metabolism; D004926:Escherichia coli / Q000201:enzymology / Q000378:metabolism; D005415:Flavins / Q000096:biosynthesis; D006136:GTP Cyclohydrolase / Q000378:metabolism*; D007700:Kinetics; D011487:Protein Conformation; D011622:Pterins / Q000096:biosynthesis; D015003:Yeasts / Q000201:enzymology* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D005415:Flavins; D011622:Pterins; D000619:Aminohydrolases; D006136:GTP Cyclohydrolase
GTP-tsiklogidrolazy mikroorganizmov i ikh rol' v obmene veshchestv.