CCK nerve terminals in the rat striatal and limbic areas originate partly in the brain stem and partly in telencephalic structures.
After direct injection of colchicine into the rat rostral caudateputamen, levels of cholecystokinin-like immunoreactive (CCK-IR) material in this part of the nucleus are significantly lowered, and CCK-IR neuronal cell bodies are not demonstrable in the caudateputamen, although numerous ones are revealed in some adjacent telencephalic regions. Direct injection of kainic acid into the rostral caudate-putamen is not followed by a decrease of CCK-IR material in the lesioned region. Twenty one days after injection of 6-hydroxydopamine into the rat ventral mesencephalon, a significant decrease of CCK-IR material is observed in the frontal pole, the pyriform cortex, the nucleus accumbens and the ventral mesencephalon itself, but not in the caudate-putamen. After brain stem hemitransection, no decrease in CCK-IR material is observed in the rostral caudate-putamen.
D000818:Animals; D001923:Brain Chemistry; D002421:Caudate Nucleus / Q000032:analysis; D002766:Cholecystokinin / Q000032:analysis*; D003078:Colchicine / Q000008:administration & dosage / Q000378:metabolism; D005260:Female; D006892:Hydroxydopamines / Q000378:metabolism; D007608:Kainic Acid / Q000378:metabolism; D009474:Neurons / Q000032:analysis; D016627:Oxidopamine; D011699:Putamen / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D006892:Hydroxydopamines; D016627:Oxidopamine; D002766:Cholecystokinin; D007608:Kainic Acid; D003078:Colchicine