[Topical dose-control relationship in high-energy radiation therapy of epithelial tumors of the nasopharynx].
The results of megavoltage irradiation at different doses in 188 patients with carcinoma of the nasopharynx treated at the Institute of Radiotherapy "L. Galvani", University of Bologna, from 1960 to 1978, are analyzed. Dose-control relationship is investigated. The incidence of failures at the primary site and in the neck is a function of dose and neoplastic volume: 5,000 rad/5 weeks for sub-clinical disease and 7,000 rad/7 weeks for massive disease appears to eradicate the tumor in a high number of cases. Prognosis of patients with extensive disease in the neck is nevertheless unfavourable, since a great number of them dies for distant metastases. It seems therefore necessary to institute clinical trials testing adjuvant chemotherapy in patients with neck stages N2-N3.
D004307:Dose-Response Relationship, Radiation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009303:Nasopharyngeal Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D009367:Neoplasm Staging; D011379:Prognosis; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy
Rapporto dose/controllo locale nel trattamento radiante con alte energie delle neoplasie epiteliali della rinofaringe.