Aspirin reduces alcohol-induced prenatal mortality and malformations in mice.
Oral alcohol administration (5.8 g/kg) on gestation day 10 resulted in an increase in both prenatal mortality and birth defects as well as decreased fetal weight in C57BL/6J mice. Aspirin pretreatment (150 mg/kg subcutaneously) significantly reduced the number of malformed pups and prevented the increase in prenatal mortality produced by alcohol. The mechanism of action remains to be elucidated.
D000014:Abnormalities, Drug-Induced / Q000517:prevention & control*; D000435:Alcoholic Intoxication / Q000150:complications; D000818:Animals; D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use*; D000431:Ethanol / Q000037:antagonists & inhibitors*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced* / Q000517:prevention & control; D006801:Humans; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D011248:Pregnancy Complications
D000431:Ethanol; D001241:Aspirin