The influence of the sweetening agent on the oral absorption of penicillin V.
Plasma concentrations of Penicillin V were determined following oral administration in children of mixtures containing different sugars as sweetening agents. Significantly higher peak plasma concentrations and area under the curve were found with sacharose than with sorbitol. Mixtures containing fructose gave intermediate values.
D000284:Administration, Oral; D002241:Carbohydrates / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption / Q000187:drug effects*; D010404:Penicillin V / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D013549:Sweetening Agents / Q000494:pharmacology*; D013997:Time Factors
D002241:Carbohydrates; D013549:Sweetening Agents; D010404:Penicillin V