[Significance of hormones in the amniotic fluid. 1. Insulin and C-peptide].
Samples of amniotic fluid of 275 healthy women were used to establish a standard profile of amniotic fluid insulin and C-peptide concentrations versus gestational age. The reasons for amniocentesis were: exclusion of chromosomal defects, rhesus immunisation, and determination of the L/S ratio. The concentrations of both peptides which were measured in the amniotic fluid in diabetics were compared with the normal profile. We found that long-term blood glucose control as estimated by the concentration of glycosylated haemoglobins in maternal blood is not well correlated with amniotic fluid insulin or C-peptide, respectively. In a few cases with poor metabolic control, we found normal insulin values, and vice versa. Since elevated insulin and C-Peptide levels in amniotic fluid correlate well with diabetic foetopathy, we conclude that measurement of both peptides provides a useful parameter in the management of a diabetic pregnancy.
D000649:Amniocentesis; D000653:Amniotic Fluid / Q000378:metabolism*; D001786:Blood Glucose / Q000378:metabolism; D002096:C-Peptide / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D006442:Glycated Hemoglobin / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000378:metabolism*; D011379:Prognosis; D012306:Risk
D001786:Blood Glucose; D002096:C-Peptide; D006442:Glycated Hemoglobin; D007328:Insulin
Die Bedeutung von Hormonen im Fruchtwasser 1. Insulin und C-Peptid.