Mutagenicity studies in a tyre plant: in-vitro activity of urine concentrates and rubber chemicals.
A possible occupational contribution to urinary mutagenicity was studied in a tyre plant, by assaying concentrates of urine from 72 workmen and 23 controls for their activity in the Ames test and microtitre fluctuation test. The results show that smoking habits but not occupation are related to the appearance of a detectable urinary mutagenicity in strain TA98. A possible synergistic effect of occupation was, however, observed among tyre builders who were smokers. Mutagenicity screening of 25 rubber chemicals, of major technological relevance and used in high volume in the workplace investigated, showed that three of them are weakly active in TA98 and TA100 (tetramethylthiuram disulfide) or TA98 alone (poly-p-dinitrosobenzene and mixed diaryl-p-phenylendiamines).
D002617:Chemical Industry; D006801:Humans; D009152:Mutagenicity Tests; D009153:Mutagens / Q000009:adverse effects / Q000032:analysis*; D009784:Occupational Diseases / Q000652:urine*; D012408:Rubber; D012486:Salmonella typhimurium / Q000235:genetics
D009153:Mutagens; D012408:Rubber