Distribution of Ia-positive cells in the pig and human pancreas.
With monoclonal antibody reacting with both human and porcine Ia antigens, we demonstrate with immunoperoxidase staining that Ia expressing endothelial cells are found in Langerhans' islets as well as in exocrine tissue of the pig and human pancreas. However, neither endocrine cells in Langerhans' islets nor acinar or ductal cells do express the Ia antigen.
D000818:Animals; D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007124:Immunoenzyme Techniques; D066298:In Vitro Techniques; D007515:Islets of Langerhans / Q000166:cytology / Q000276:immunology; D010179:Pancreas / Q000166:cytology / Q000276:immunology*; D013552:Swine
D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II