[Treatment of recurrent gastrointestinal cancer].
There are various patterns of recurrence of gastric and colorectal cancer after radical resection. In case of residual stomach recurrence, re-resection is sometimes feasible. Chemotherapy in such a case consists of combined chemotherapy by arterial infusion for induction of remission and administration of oral preparation and/or suppositories for maintenance. The results obtained from our clinic (recurrent gastric cancer: 101 cases, colorectal cancer: 27 cases) were shown as follows. The 50% survival period was 5 months. The twenty-one cases out of 101 cases in gastric cancer were survived more than one years, because they received the intensive chemotherapy such as arterial infusion chemotherapy and oral or rectal administration of FT. In case of recurrent colorectal cancer, 17 cases of 27 patients has multiple liver metastasis. The most patients of liver metastasis were treated with selective arterial infusion chemotherapy with 5-FU plus ACNU or MMC. And the efficacy of arterial infusion chemotherapy was remarkable. Our efforts must be made to continue any treatment as long as possible and change drugs as necessary. Also we must be made to keep general condition of the patients as good as possible using support therapy such as IVH, prevention of infection, immunotherapy, drainage so on.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D007261:Infusions, Intra-Arterial; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D015376:Nimustine; D009607:Nitrosourea Compounds / Q000008:administration & dosage; D012004:Rectal Neoplasms / Q000188:drug therapy*; D013274:Stomach Neoplasms / Q000188:drug therapy*
D008937:Mitomycins; D009607:Nitrosourea Compounds; D015376:Nimustine; D016685:Mitomycin; D004317:Doxorubicin