Immune thrombocytopenias.
The common denominator of this group of disorders is bleeding due to antibody-mediated platelet destruction. The variations in clinical manifestation--ranging from mild to fatal--reflect the diverse origins of the troublesome antibodies: transplacental, exogenous, and autogenous. Treatment--if necessary--may involve steroids, exchange transfusion, apheresis, or splenectomy.
D000918:Antibody Specificity; D000937:Antigen-Antibody Reactions; D001323:Autoantibodies / Q000276:immunology; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D001792:Blood Platelets / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007154:Immune System Diseases / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D007231:Infant, Newborn; D007519:Isoantigens / Q000276:immunology; D017713:Platelet Transfusion; D011696:Purpura, Thrombocytopenic / Q000175:diagnosis / Q000276:immunology / Q000628:therapy; D013921:Thrombocytopenia / Q000175:diagnosis* / Q000276:immunology / Q000628:therapy; D065227:Transfusion Reaction
D001323:Autoantibodies; D006680:HLA Antigens; D007519:Isoantigens