Clinical trial of flurbiprofen to maintain pupillary dilation during cataract surgery.
Thirty-four patients undergoing elective extracapsular cataract extraction were divided into a control group (18 patients) and treatment group (16 patients) in a double-blinded study to evaluate the nonsteroidal, anti-inflammatory drug flurbiprofen as an aid for maintaining pupil dilation during surgery. Both groups received the routine preoperative dilating drops, and the treatment group also received 0.03% topical flurbiprofen. After lens extraction, the change in pupil diameter from the preoperative measurement averaged -2.5 mm in the treatment group and -3.9 mm in the control group. The difference between groups was significant (p = 0.003), favoring flurbiprofen for maintaining pupil dilation.
D000328:Adult; D000368:Aged; D002387:Cataract Extraction / Q000379:methods*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005480:Flurbiprofen / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009184:Mydriatics / Q000008:administration & dosage*; D011422:Propionates / Q000008:administration & dosage*; D011680:Pupil / Q000187:drug effects*; D011897:Random Allocation
D009184:Mydriatics; D011422:Propionates; D005480:Flurbiprofen