The quantitative structure-activity relationship approach to the mutagenicity of N-nitrosomethylaniline compounds.
In order to clarify the correlations between the substituent properties and the mutagenicity of N-nitrosomethylaniline compounds, the quantitative structure-activity relationship approach has been applied. The results indicate that the property and the shape of the para-substituent groups influence the mutagenic potency, although this has not yet been verified for the meta-substituted compounds.
D000814:Aniline Compounds / Q000494:pharmacology*; D000818:Animals; D001711:Biotransformation; D006224:Cricetinae; D005260:Female; D008297:Male; D008647:Mesocricetus; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D009602:Nitrosamines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship
D000814:Aniline Compounds; D009153:Mutagens; D009602:Nitrosamines; C014102:N-methyl-N-nitrosoaniline