[Changes in the epithelial permeability of the large intestine of mice in the process of carcinogenesis].
1,2-dimethylhydrazine (DMH), a colon carcinogen, being injected weekly to BALB/c mice, inhibits an active sodium transport, increases the transepithelial passive ion permeation and decreases ion selectivity in the descending colon. A single DMH injection leads to the same alterations, manifested for a month, followed by normalization of all the parameters to the control value. Distinctive, wavy changes in electrophysiological parameters were noted after a single injection of "non-colon" carcinogen 7,12-dimethyl-benz(alpha)antracen. It is supposed that the prolonged drop in active sodium transport, transepithelial resistance and ion selectivity are specific reactions of the colonic epithelium to carcinogenic treatment with DMH.
D019813:1,2-Dimethylhydrazine; D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002273:Carcinogens / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004127:Dimethylhydrazines / Q000494:pharmacology; D004594:Electrophysiology; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D005260:Female; D007414:Intestinal Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D007420:Intestine, Large / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D012964:Sodium / Q000378:metabolism; D013997:Time Factors
D002273:Carcinogens; D004127:Dimethylhydrazines; D015127:9,10-Dimethyl-1,2-benzanthracene; D012964:Sodium; D019813:1,2-Dimethylhydrazine
Izmenenie pronitsaemosti épiteliia tolstoĭ kishki mysheĭ v protsesse kantserogeneza.