Bone cell differentiation and growth factors.
Bone morphogenetic protein and bone-derived growth factors are biochemical tools for research on induced cell differentiation and local mechanisms controlling cell proliferation. Bone morphogenetic protein irreversibly induces differentiation of perivascular mesenchymal-type cells into osteoprogenitor cells. Bone-derived growth factors are secreted by and for osteoprogenitor cells and stimulate DNA synthesis. Bone generation and regeneration are attributable to the co-efficiency of bone morphogenetic protein and bone-derived growth factors.
D000818:Animals; D001846:Bone Development; D001857:Bone Matrix / Q000187:drug effects / Q000502:physiology; D019485:Bone Morphogenetic Proteins; D001859:Bone Neoplasms / Q000503:physiopathology; D002417:Cattle; D002454:Cell Differentiation; D004273:DNA, Neoplasm / Q000378:metabolism; D004285:Dogs; D006133:Growth Substances / Q000502:physiology*; D006168:Guinea Pigs; D000882:Haplorhini; D006801:Humans; D007335:Insulin-Like Growth Factor II; D051379:Mice; D010012:Osteogenesis; D012516:Osteosarcoma / Q000503:physiopathology; D011506:Proteins / Q000494:pharmacology / Q000502:physiology; D011817:Rabbits; D051381:Rats
D019485:Bone Morphogenetic Proteins; D004273:DNA, Neoplasm; D006133:Growth Substances; C035170:IGF2 protein, human; D011506:Proteins; D007335:Insulin-Like Growth Factor II