Systemic and carotid haemodynamics and plasma renin activity during deliberate hypotension in dogs: a comparison of sodium nitroprusside with nicergoline.
This study was designed to compare at the same level of hypotension (-30%) nitroprusside (SNP) and nicergoline (NIC) effects on systemic haemodynamics and carotid haemodynamics (pulsed Doppler) and on plasma renin activity (PRA) in 20 anaesthetized dogs before and at the 20th minute of hypotension. In SNP group (n = 9) cardiac output (CO) and heart rate (HR) increased. Stroke volume (SV), pulmonary wedge pressure (PWP), central venous pressure (CVP) and systemic vascular resistance (SVR) decreased. Common carotid diameter (D) increased and blood flow velocity (V) decreased with constant common carotid blood flow (CCBF). CCBF/CO ratio was unchanged. PRA levels increased. In NIC group (n = II), HR, CO, SV were unchanged and PWP, CVP, SVR decreased. D, V and CCBF were unchanged. CCBF/CO ratio increased and PRA was unchanged. NIC provoked mild hypotension without reflex sympathetic activation unlike SNP. Only SNP dilated large arteries. The autoregulation of CCBF is maintained with both drugs but CCBF/CO ratio is increased only with NIC.
D000758:Anesthesia; D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure; D002302:Cardiac Output; D002339:Carotid Arteries / Q000503:physiopathology*; D004285:Dogs; D004873:Ergolines / Q000627:therapeutic use / Q000633:toxicity; D005292:Ferricyanides / Q000627:therapeutic use / Q000633:toxicity; D006339:Heart Rate; D006439:Hemodynamics; D007022:Hypotension / Q000139:chemically induced / Q000503:physiopathology*; D009530:Nicergoline / Q000627:therapeutic use / Q000633:toxicity; D009599:Nitroprusside / Q000627:therapeutic use / Q000633:toxicity; D012083:Renin / Q000097:blood*; D013318:Stroke Volume; D014655:Vascular Resistance
D004873:Ergolines; D005292:Ferricyanides; D009599:Nitroprusside; D012083:Renin; D009530:Nicergoline