[Adrenergic nerve related agents and prostaglandin I2 in the perfused cutaneous vascular preparations].
In the present study, the effects of prostaglandin I2 (PGI2) on the vasoconstrictor response to adrenergic nerve relating agents was examined using the perfused arterial preparations, i.e., the isolated perfused central artery of a rabbit ear and its perfused arterial segment. The following results were obtained. PGI2, 3.0 to 9.0 ng/ml, slightly enhanced not only the vasoconstrictor response to electrical stimulation of the perivascular sympathetic nerve (VSNS), and that to the exogenously applied noradrenaline, but also the noradrenaline-induced contracture. In the experiment examining the effect of VSNS on 6-keto-PGF1 alpha, a main metabolite of PGI2, levels in the effluent perfusate, it was clarified that 6-keto-PGF1 alpha levels following VSNS were lower than those before VSNS. These results seem to suggest that PGI2 is a weak vasoconstrictor in a rabbit ear and the endothelium of vascular wall would be inclined to be damaged by the mobilization of an adrenergic nerve transmitter.
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000294:innervation; D004357:Drug Synergism; D004558:Electric Stimulation; D011464:Epoprostenol / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D010477:Perfusion; D011817:Rabbits; D012867:Skin / Q000098:blood supply; D014661:Vasoconstriction / Q000187:drug effects*
D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol; D009638:Norepinephrine