Is the direct effect of naloxone on liver cell metabolism an artifact?
Proprietary naloxone hydrochloride (Narcan) acts on isolated hepatocytes from 24-h starved rats to increase 14CO2 production from [1-14C]oleate and to reverse in part the inhibitory effect of ethanol on the oxidation of [1-14C]oleate to 14CO2. The effects are attributable not to naloxone itself, but to the methyl p-hydroxybenzoate present in Narcan as a preservative. The question is posed as to whether methyl p-hydroxybenzoate and p-hydroxybenzoate contribute to the reported antagonism by proprietary naloxone of acute ethanol intoxication in vivo.
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D007657:Ketone Bodies / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009270:Naloxone / Q000494:pharmacology*; D019301:Oleic Acid; D009829:Oleic Acids / Q000378:metabolism*; D010226:Parabens / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D007657:Ketone Bodies; D009829:Oleic Acids; D010226:Parabens; D002245:Carbon Dioxide; D019301:Oleic Acid; D009270:Naloxone; D000431:Ethanol; C015358:methylparaben