Delay in the onset of parturition in the rat following prenatal administration of developmental toxicants.
The duration of gestation was determined in Sprague-Dawley albino rats exposed during days 6-18 of pregnancy to diethylstilbestrol (DES) or 3,4,3',4'-tetrachlorobiphenyl (4CB). Each compound produced a delay in the onset of parturition compared to corn-oil-treated controls. The incidence of perinatal mortality was significantly elevated in animals born after 22 days of gestation in both control and treated litters.
D000818:Animals; D004054:Diethylstilbestrol / Q000633:toxicity*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects*; D005865:Gestational Age; D007743:Labor, Obstetric / Q000187:drug effects*; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D004054:Diethylstilbestrol; D011078:Polychlorinated Biphenyls; C028451:3,4,3',4'-tetrachlorobiphenyl