An erythrocyte membrane antigen associated with X-linked muscular dystrophy.
Goat antiserum was prepared against erythrocyte membranes obtained from a man who had X-linked muscular dystrophy. When cross-adsorbed with control membranes and tested on double immunodiffusion plates or by binding to intact erythrocytes suspended in thin-layer agar plates, this antiserum discriminated between membranes from phenotypically normal controls and dystrophic men, and between controls and obligate female dystrophy carriers. It also identified two populations among a small sample of women at risk for being dystrophy carriers.
D000293:Adolescent; D000328:Adult; D000906:Antibodies / Q000235:genetics / Q000276:immunology; D000941:Antigens / Q000235:genetics / Q000276:immunology*; D002648:Child; D004910:Erythrocyte Membrane / Q000276:immunology* / Q000648:ultrastructure; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D005779:Immunodiffusion; D008297:Male; D008875:Middle Aged; D009136:Muscular Dystrophies / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D010375:Pedigree; D014960:X Chromosome
D000906:Antibodies; D000941:Antigens