[Toxic effect of lithium salts on the pregnant rat and on the prenatal development of the fetus].
A study was made of toxic effect of lithium carbonate and lithium hydroxybutyrate in doses of 160 and 500 mg/kg (1/4 LD50) respectively on pregnant rats and development of fetuses. The doses of both the drugs contained an equal amount of lithium (30 mg/kg). It was established that toxicity of the drugs in pregnancy rises almost two-fold as compared to that seen in non-pregnant animals. At the same time the toxic action of lithium hydroxybutyrate was more powerful than that of lithium carbonate. However, the latter drug was found to have a greater embryotoxicity. Apparently, the differences in toxicity and embryotoxicity of the lithium salts are to a definite measure determined by anionic component of salts.
D000818:Animals; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects*; D006885:Hydroxybutyrates / Q000633:toxicity; D008094:Lithium / Q000633:toxicity*; D016651:Lithium Carbonate; D009942:Organometallic Compounds; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D006885:Hydroxybutyrates; D009942:Organometallic Compounds; D016651:Lithium Carbonate; C022826:lithium hydroxybutyrate; D008094:Lithium
Toksicheskoe vliianie soleĭ litiia na beremennykh krys i antenatal'noe razvitie ploda.