Ultrastructural distribution of glycogen in pancreatic islets of steroid diabetic rats.
In the islets of rat pancreas, steroid diabetes induced by triamcinolon-acetonid led to glycogen infiltration of B cells. Ultracytochemically, glycogen was detected within 24 hours after glucocorticoid administration using the periodic acid-silver proteinate method according to Maxwell (1978). Glycogen was primarily located in the cytoplasm of granulated B cells but could also be detected in the halo of the secretory granules of these cells. The amount of glycogen increased during the course of the 5 day experiment. The A, D, and PP cells were free of glycogen.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism*; D007515:Islets of Langerhans / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008722:Methods; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014222:Triamcinolone Acetonide
D006003:Glycogen; D014222:Triamcinolone Acetonide