[Therapeutic use of prostacyclin in cardiovascular pathology].
After a brief survey of the already well known functions of tromboxane and prostacyclin both in physiological and pathological conditions, the data found in the literature on the therapeutical use of prostacyclin are discussed. The positive results obtained in the treatment of arteriosclerosis obliterans of the lower limbs, of Raynaud's syndrome, of ischaemic stroke and of ischaemic heart diseases, together with the very modest side effects of prostacyclin, suggest to continue with prostacyclin therapy even if its mechanism of action is not yet clear.
D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001162:Arteriosclerosis Obliterans / Q000188:drug therapy; D002318:Cardiovascular Diseases / Q000188:drug therapy*; D002561:Cerebrovascular Disorders / Q000188:drug therapy; D003327:Coronary Disease / Q000188:drug therapy; D003577:Cytochrome P-450 Enzyme System; D011464:Epoprostenol / Q000096:biosynthesis / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D019746:Intramolecular Oxidoreductases; D011928:Raynaud Disease / Q000188:drug therapy; D013928:Thromboxane A2 / Q000627:therapeutic use
D001095:Arachidonic Acids; D016718:Arachidonic Acid; D013928:Thromboxane A2; D003577:Cytochrome P-450 Enzyme System; D011464:Epoprostenol; D019746:Intramolecular Oxidoreductases; C022461:prostacyclin synthetase
L'impiego terapeutico della prostaciclina in patologia cardiovascolare.