Supplementation of total parenteral nutrition solutions with ferrous citrate.
Daily infusion of a total parenteral nutrition (TPN) formulation containing 1 liter of 5.5% Travasol provides less than 0.1 milligrams of iron. By comparison, a formulation which includes a liter of 10% Travamin provides 2 milligrams of iron per day. To meet iron requirements in patients infusing formulations containing Travasol, iron was added as ferrous citrate. In in virto experiments, 74% of this iron was available to transferrin. In seven patients in whom in vivo availability was tested by red cell incorporation, the mean availability was 81%. Ferrous citrate is recommended as a safe, effective additive to TPN solutions for adult patients requiring iron supplements.
D000328:Adult; D019343:Citric Acid; D005260:Female; D005296:Ferrous Compounds / Q000008:administration & dosage*; D005526:Food, Formulated; D006801:Humans; D007501:Iron / Q000008:administration & dosage* / Q000097:blood; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition / Q000379:methods*; D010289:Parenteral Nutrition, Total / Q000379:methods*; D014168:Transferrin / Q000032:analysis
D005296:Ferrous Compounds; D014168:Transferrin; D019343:Citric Acid; C016600:ferrous citrate; D007501:Iron