Vancomycin in infants and children: a review of pharmacology and indications for therapy and prophylaxis.
Although used only rarely and cautiously by paediatricians in the past because of fear of toxicity, vancomycin has become part of the clinician's armamentarium to treat serious infections caused by Gram-positive bacteria, and for specific prophylaxic indications. The pharmacokinetics in infants and children have been recently studied and, while the new information has been helpful in determining more precisely correct doses, more data are needed, especially in young infants. The relatively new roles for vancomycin in the prevention of bacterial infection also require further clarification.
D000293:Adolescent; D000328:Adult; D000818:Animals; D001166:Arteriovenous Shunt, Surgical / Q000009:adverse effects; D002415:Cats; D002648:Child; D002675:Child, Preschool; D003773:Dental Plaque / Q000517:prevention & control; D004195:Disease Models, Animal; D004697:Endocarditis, Bacterial / Q000517:prevention & control; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007275:Injections, Intravenous / Q000009:adverse effects; D007700:Kinetics; D008297:Male; D011247:Pregnancy; D011817:Rabbits; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000517:prevention & control; D014640:Vancomycin / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use
D014640:Vancomycin