Potentiating effects of caffeine on teratogenicity of alkylating agents in mice.
Teratogenic to subteratogenic doses of x-ray, mitomycin C, MNNG, thio-TEPA, cyclophosphamide, and chlorambucil were administered to pregnant ICR mice together with caffeine at doses of 12.5, 25, or 50 mg/kg on day 11 of gestation. Fetuses were examined for gross malformations on day 18 of gestation. The teratogenicity of mitomycin C was significantly potentiated by caffeine at a dose as low as 12.5 mg/kg. The teratogenicity of chlorambucil was also significantly potentiated by caffeine at 50 mg/kg, but similar potentiation was not observed for x-ray, MNNG, thio-TEPA, and cyclophosphamide.
D000014:Abnormalities, Drug-Induced / Q000503:physiopathology*; D000016:Abnormalities, Radiation-Induced / Q000503:physiopathology*; D000477:Alkylating Agents / Q000633:toxicity*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000633:toxicity; D002110:Caffeine / Q000633:toxicity*; D002699:Chlorambucil / Q000633:toxicity; D003520:Cyclophosphamide / Q000633:toxicity; D004357:Drug Synergism; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005327:Fetal Resorption; D008769:Methylnitronitrosoguanidine / Q000633:toxicity; D051379:Mice; D008815:Mice, Inbred Strains; D016685:Mitomycin; D008937:Mitomycins / Q000633:toxicity; D011247:Pregnancy; D013723:Teratogens; D013852:Thiotepa / Q000633:toxicity
D000477:Alkylating Agents; D000903:Antibiotics, Antineoplastic; D008937:Mitomycins; D013723:Teratogens; D008769:Methylnitronitrosoguanidine; D002699:Chlorambucil; D002110:Caffeine; D016685:Mitomycin; D003520:Cyclophosphamide; D013852:Thiotepa