[Preliminary note on anti-insulin antibody formation in diabetics treated with porcine insulin].
In the present study, we have tested the sera of sixty five diabetic patients treated with insulin, researching the action of some physiologic and therapeutic factors (sex, age, insulin dose and time of treatment), to production of anti-insulin antibodies. Our results have shown that an important percentage of diabetic patients treated by porcine insulin produce antibodies: 72% of studied patients, concerning chiefly all the women and patients under-fourty years old. However our results have not pointed out any relation between the administered insulin dose versus the anti-insulin antibodies production, in spite of the early production of these antibodies in a great part of the patients.
D000328:Adult; D000367:Age Factors; D000368:Aged; D000818:Animals; D000917:Antibody Formation; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D007330:Insulin Antibodies / Q000096:biosynthesis*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D013552:Swine
D007328:Insulin; D007330:Insulin Antibodies
Note préliminaire sur la production d'anticorps anti-insuline chez les diabétiques traités par l'insuline porcine.