Metabolites of 2,4',5-trichlorobiphenyl in rats.
Nineteen metabolites of 2,4',5-trichlorobiphenyl were isolated from rat urine, faeces and bile. These metabolites resulted from one or more of the following transformations: dechlorination, hydroxylation, thiolation, methylthiolation, methylthio oxidation, dihydrodiol formation, mercapturic acid formation and conjugation with glucuronic acid. Mercapturic acid-pathway metabolites were the major metabolites in the bile. Methylthio-, methylsulphinyl- and methylsulphonyl-containing metabolites were the major metabolites in the faeces of control rats. A synthetic pathway for the preparation of sulphur-containing metabolites of trichlorobiphenyl is described.
D000818:Animals; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D005243:Feces / Q000032:analysis; D008297:Male; D013058:Mass Spectrometry; D011078:Polychlorinated Biphenyls / Q000378:metabolism* / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains
C015550:2,4',5-trichlorobiphenyl; D011078:Polychlorinated Biphenyls