The inhibitory effects of ethoxyquin on the carcinogenic action of aflatoxin B1 in rats.
Ethoxyquin (EQ), a widely used antioxidant, inhibits the carcinogenic effects of polycyclic aromatic hydrocarbons. The aim of the present study was to determine whether EQ modifies the hepatocarcinogenic effects of aflatoxin B1 (AFB1) in rats. Both compounds were administered in the diet. Rats were fed either EQ for 2 weeks and then AFB1 for 6 weeks, EQ and AFB1 simultaneously or EQ following the cessation of AFB1 treatment. The results indicate that EQ can inhibit the hepatocarcinogenic effects of AFB1 and that the most effective inhibition is obtained when EQ and AFB1 are given simultaneously.
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005015:Ethoxyquin / Q000494:pharmacology*; D008099:Liver / Q000033:anatomy & histology; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D009929:Organ Size / Q000187:drug effects; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344
D000348:Aflatoxins; D011804:Quinolines; D003577:Cytochrome P-450 Enzyme System; D016604:Aflatoxin B1; D005015:Ethoxyquin