Thyrotropin-releasing hormone reverses the hypotension and bradycardia produced by leukotriene D4 in unanesthetized guinea pigs.
We have utilized an unanesthetized guinea pig model to study the cardiovascular effects of leukotriene D4 (LTD4), a compound implicated in slow reacting substance of anaphylaxis (SRS-A). Intravenous (IV) administration of LTD4 at 5 micrograms/kg produced profound hypotension, bradycardia, hypoxia and acidosis. The hypotension and bradycardia were rapidly and completely reversed by IV thyrotropin-releasing hormone (TRH) at a dose of 2 mg/kg. In contrast, TRH treatment had no effect on the hypoxia or acidosis induced by LTD4. These data provide a potential physiological link between two distinct classes of endogenous substances and may have implications for the therapy of anaphylactic shock.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001919:Bradycardia / Q000139:chemically induced; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects*; D007022:Hypotension / Q000139:chemically induced; D007700:Kinetics; D008297:Male; D013189:SRS-A / Q000494:pharmacology*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D013189:SRS-A; D013973:Thyrotropin-Releasing Hormone