[Therapeutic and opsonizing effect of specific antibacterial immunoglobulins in experimental Klebsiella septicemia in mice].
Intravenous infection of NMRI mice with a highly virulent strain of Klebsiella pneumoniae induced protracted septicemia with high lethality. Treatment of the animals with specific rabbit immunoglobulins was able to lower mortality significantly if the immunoglobulins were administered no later than 6 hours after infection. In cyclophosphamid-treated mice, even inocula as low as 10-20 organisms proved to be highly lethal. Immunoglobulins were similarly protective under these conditions and significantly lowered mortality even when injected as late as 8 hours after infection. When immunocompromised mice were infected with higher challenge inocula, the therapeutic effect decreased and the time interval allowing efficient therapy became shorter. However, even if immunoglobulin therapy was performed too late, it was able to delay mortality for several days.
D000818:Animals; D000907:Antibodies, Bacterial / Q000008:administration & dosage*; D003520:Cyclophosphamide / Q000009:adverse effects; D007106:Immune Sera; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000008:administration & dosage*; D007710:Klebsiella Infections / Q000401:mortality / Q000628:therapy*; D007711:Klebsiella pneumoniae / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D011817:Rabbits / Q000276:immunology; D018805:Sepsis / Q000401:mortality / Q000628:therapy*; D013997:Time Factors
D000907:Antibodies, Bacterial; D007106:Immune Sera; D007136:Immunoglobulins; D003520:Cyclophosphamide
Therapeutischer und opsonisierender Effekt von spezifischen antibakteriellen Immunglobulinen bei experimenteller Klebsiellensepsis der Maus.