[Effect promoting the rejection of an allograft of skin in rabbits treated with a high dose of 6-mercaptopurine].
Present findings suggest that the preventive inoculation of a single high dose of 6-mercaptopurine (6-MP) may induce in rabbits the accelerated rejection of a skin allograft. This phenomenon may be explained by an enhancing or adjuvant effect of the agent on the mechanism of the immune response to the graft.
D000818:Animals; D000917:Antibody Formation; D005260:Female; D006084:Graft Rejection / Q000187:drug effects*; D008297:Male; D015122:Mercaptopurine / Q000494:pharmacology*; D011817:Rabbits; D016038:Skin Transplantation
D015122:Mercaptopurine
Sull'effetto promuovente la reiezione di un alloinnesto di cute nel coniglio trattato con una dose elevata di 6-mercaptopurina.