[Mutagenic action of 5 prospective pesticides on mouse bone marrow, in a culture of human peripheral blood lymphocytes and on saccharomycete yeasts].
Five pesticides are studied for their mutagenicity in bone marrow cells of mice, culture of human peripheral lymphocytes and yeasts Saccharomyces cerevisiae. It is established that dimatyph (diaethylene imidamido-thio-phosphorous acid) induced potent mutagenic effect in all three test-systems; endosulfan was genetically active in mice and yeasts. Cypermethrin increased the level of chromosome aberrations in mice bone marrow cells only in a high dose. Picloram was genetically active only in yeasts. Crotoxyphos did not reveal mutagenicity in all the tests used. The carried studies confirm that various tests should be used for detecting mutagenic activity of pesticides.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008677:Metaphase / Q000187:drug effects; D051379:Mice; D009152:Mutagenicity Tests; D010575:Pesticides / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000187:drug effects*
D010575:Pesticides
Izuchenie mutagennogo deĭstviia piati perspektivnykh pestitsidov na kostnom mozge mysheĭ, v kul'ture limfotsitov perifericheskoĭ krovi cheloveka i na drozhzhakh-sakharomitsetakh.