Isolated gonadotropin deficiency in three sisters.
Three female siblings with isolated gonadotropin deficiency were studied. None demonstrated hyposmia or craniofacial abnormalities. Single doses of luteinizing hormone-releasing hormone and thyrotropin-releasing hormone (TRH) produced markedly different responses within the kindred. Following administration of TRH, one subject displayed a sharp rise in prolactin, but thyrotropin did not change.
D000293:Adolescent; D000328:Adult; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D005951:Glucose Tolerance Test; D007987:Gonadotropin-Releasing Hormone; D006065:Gonadotropins, Pituitary / Q000172:deficiency*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D010375:Pedigree; D011388:Prolactin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone
D006065:Gonadotropins, Pituitary; D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone