[Xeroderma pigmentosum: development of photoformation of hydrogen peroxide and catalytic activity in skin cells; application to an early diagnosis and to a tentative treatment].
In Xeroderma pigmentosum (XP) a genetic-recessive ultraviolette-hypersensitive disease we found an accumulation of photoproduced H2O2 in skin cells accompanied by a breakdown of the catalatic activity. Both disorders intensified as the disease progressed. Concomitantly with these processes, one electrochemical peak of urine decreases. By the time epitheliomas appeared, this peak was no longer detectable. Several applications to the skin of a cream containing catalase seemed to prevent the formation and the evolution of neoplastic tumors during the treatment.
D001706:Biopsy; D002374:Catalase / Q000627:therapeutic use*; D006801:Humans; D006861:Hydrogen Peroxide / Q000378:metabolism*; D007700:Kinetics; D012867:Skin / Q000503:physiopathology* / Q000528:radiation effects; D014466:Ultraviolet Rays; D014467:Ultraviolet Therapy; D014983:Xeroderma Pigmentosum / Q000175:diagnosis / Q000503:physiopathology* / Q000628:therapy
D006861:Hydrogen Peroxide; D002374:Catalase
Xeroderma pigmentosum: évolution de la photoformation d'eau oxygénée et de l'activité catalatique dans les cellules de la peau; application à un diagnostic précoce et à une tentative de traitement.