Bone marrow transplantation for immunodeficiency.
Bone marrow transplantation for severe combined immunodeficiency disease was studied. Clinical and immunological analysis of four patients showed marked impairment of both humoral and cellular immune functions, suggesting lymphoid stem cell defect. Two of them received successful bone marrow transplantation. The clinical course and process of immunological reconstitution after bone marrow transplantation in these two cases was presented. Some characteristics of bone marrow transplantation for severe combined immunodeficiency disease were discussed in comparison with those of malignant hematologic disorders. Future directions of bone marrow transplantation for severe combined immunodeficiency disease, e.g., transplantation from an HLA incompatible parental donor, were also discussed.
D000293:Adolescent; D016026:Bone Marrow Transplantation; D006801:Humans; D007109:Immunity; D007153:Immunologic Deficiency Syndromes / Q000276:immunology / Q000628:therapy*; D007223:Infant; D008297:Male