Gilvocarcins, new antitumor antibiotics. 5. Biosynthesis of gilvocarcins: incorporation of 13C-labeled compounds into gilvocarcin aglycones.
The biosynthesis of the aglycones of gilvocarcins V and M has been studied with 13C-labeled precursors. The aglycones have been shown to be formed via the acetate pathway and a route for their biosynthesis is proposed which involves secondary addition of an alkyl group.
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D001412:Bacillus subtilis / Q000254:growth & development / Q000378:metabolism*; D002247:Carbon Isotopes; D003374:Coumarins; D005285:Fermentation; D006027:Glycosides / Q000096:biosynthesis; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D002247:Carbon Isotopes; D003374:Coumarins; D006027:Glycosides; C031782:gilvocarcin M; C031781:gilvocarcin V; C033792:gilvocarcin E