Platelet-activating factor.
Our ability to chemically characterize and synthesize this autacoid of allergy and inflammation has given us a unique opportunity to study these important molecules in a highly disciplined fashion. It has also opened the door to a vista of research approaches to define PAF's normal physiologic role as well as its actions as an immunopathologic mediator. Recent work is described.
D000707:Anaphylaxis / Q000276:immunology; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000276:immunology; D002319:Cardiovascular System / Q000187:drug effects / Q000276:immunology; D003888:Desensitization, Immunologic; D006168:Guinea Pigs; D006801:Humans; D007114:Immunization; D007073:Immunoglobulin E / Q000276:immunology; D008168:Lung / Q000187:drug effects / Q000276:immunology; D010215:Papio; D010972:Platelet Activating Factor / Q000096:biosynthesis / Q000276:immunology / Q000502:physiology*; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D013997:Time Factors; D014661:Vasoconstriction / Q000187:drug effects
D010972:Platelet Activating Factor; D007073:Immunoglobulin E