HLA-DB3: population distribution and family studies of a new HLA-D antigen associated with HLA-D antigen associated with HLA-DR4 in Caucasoids.
On the basis of studies with 6 HTCs in four different families the new cluster DB3 identified in the 8th Workshop can be considered an established specificity of the HLA-D series. In 112 healthy Caucasoids resident in South East England the frequency of this antigen was 2.6% similar to the frequency found in 142 Caucasoid patients with rheumatoid arthritis. The frequency in 54 unrelated Chinese individuals from Shanghai and of 120 Nigerians was 7.5% and 3%, respectively. All Caucasoid individuals who were DB3 were also DR4 whereas no such association was found in the two other population groups.
D044466:Asian People; D044383:Black People; D002681:China; D004739:England; D005260:Female; D005802:Genes, MHC Class II; D006681:HLA-D Antigens; D015804:HLA-DR4 Antigen; D059826:HLA-DRB3 Chains; D006720:Homozygote; D006801:Humans; D008297:Male; D009549:Nigeria / Q000208:ethnology; D010375:Pedigree; D044469:Racial Groups; D044465:White People
D006681:HLA-D Antigens; D015804:HLA-DR4 Antigen; D059826:HLA-DRB3 Chains