Endothelial cell origin of thorium oxide-induced angiosarcoma of liver.
A 72-year-old woman was found at autopsy to have hepatic angiosarcoma approximately 30 years after systemic thorium oxide (Thorotrast) injection. Intracytoplasmic localization of factor VIII-related antigen was demonstrated by an immunoperoxidase method, confirming the endothelial cell origin of the tumor.
D000368:Aged; D000941:Antigens / Q000032:analysis; D004727:Endothelium / Q000276:immunology / Q000473:pathology; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D005260:Female; D006394:Hemangiosarcoma / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D013911:Thorium Dioxide / Q000009:adverse effects*; D014841:von Willebrand Factor
D000941:Antigens; D014841:von Willebrand Factor; D005169:Factor VIII; D013911:Thorium Dioxide