[Mechanism of action of N-acetylglucosaminyl-N-acetylmuramylalanyl-D-isoglutamine on the nonspecific anti-infection resistance of mice].
The stimulating influence of glucose-containing muramyldipeptide (GMDP) on the nonspecific resistance of mice was shown to depend on the features of the pathogenesis of the infection. Thus, the intraperitoneal injection of GMDP increased the survival rate of mice infected with Escherichia coli, but had no stimulating effect on the resistance of the animals to Salmonella typhimurium natural infection in whose pathogenesis macrophages played an essential role. Experiments demonstrated that GMDP was capable of enhancing the ingestive function of macrophages, but did not increase their bactericidal activity with respect to this infection.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000627:therapeutic use*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D004927:Escherichia coli Infections / Q000517:prevention & control; D005260:Female; D007113:Immunity, Innate / Q000187:drug effects; D008297:Male; D051379:Mice; D010587:Phagocytosis / Q000187:drug effects; D012480:Salmonella Infections / Q000517:prevention & control; D012486:Salmonella typhimurium; D013997:Time Factors
D000119:Acetylmuramyl-Alanyl-Isoglutamine
K mekhanizmu deĭstviia N-atsetilgliukozaminil-N-atsetilmuramilalanil-D-izoglutamina na nespetsificheskuiu protivoinfektsionnuiu rezistentnost' mysheĭ.