99mTc-propylene amine oxime (99mTc-PnAO); a potential brain radiopharmaceutical.
Propylene amine oxime (PnAO) forms a neutral lipid soluble complex with 99mTc. 99mTc-PnAO can be prepared by simple reduction of 99mTc-pertechnetate with stannous ion in the presence of excess PnAO in saline at or near neutral pH. This agent will passively penetrate biological membranes including the intact blood-brain barrier (BBB) as evidenced by the high brain uptake observed shortly after IV injection. The first-pass extraction efficiency in baboons was estimated to be 80% at normal blood flow. This agent or a derivatized form of 99mTc-PnAO may be useful in assessment of regional cerebral blood flow (rCBF) in humans.
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging*; D004285:Dogs; D006801:Humans; D051379:Mice; D015609:Organotechnetium Compounds; D010091:Oximes / Q000378:metabolism; D010215:Papio; D004369:Pentetic Acid; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium / Q000378:metabolism; D016284:Technetium Tc 99m Pentetate
D015609:Organotechnetium Compounds; D010091:Oximes; C044310:technetium Tc 99m propylene amine oxime; D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate