Immunoproliferative small-intestinal disease: follow-up of an alpha-chain negative, lymphoma-free group.
Six patients had the clinical and pathological features of immunoproliferative small-intestinal disease (IPSID). All were female with malabsorption or growth retardation in whom testing for alpha-heavy chains was repeatedly negative. They were followed for a mean of 7.5 years, during which time no significant alteration in the jejunal biopsy appearances of five patients has occurred, none have developed lymphomas.
D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000209:etiology; D006362:Heavy Chain Disease; D006801:Humans; D007154:Immune System Diseases / Q000175:diagnosis* / Q000378:metabolism; D007137:Immunoglobulin alpha-Chains / Q000032:analysis; D007408:Intestinal Absorption; D007410:Intestinal Diseases / Q000175:diagnosis / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism / Q000473:pathology; D008223:Lymphoma; D010950:Plasma Cells / Q000473:pathology; D011379:Prognosis
D007137:Immunoglobulin alpha-Chains