Nucleotide sequence of a light chain gene of the mouse I-A subregion: A beta d.
Ia (I region-associated) antigens are cell-surface glycoproteins involved in the regulation of immune responsiveness. They are composed of one heavy (alpha) and one light (beta) polypeptide chain. We have sequenced the gene encoding the A beta d chain of the BALB/c mouse. The presence of six exons is predicted by comparison with the complementary DNA sequences of human beta chains and with partial protein sequence data for the A beta d polypeptide. Sequence comparisons have been made to other proteins involved in immune responses and the consequent implications for the evolutionary relationships of these genes are discussed.
D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D003062:Codon; D005796:Genes; D005802:Genes, MHC Class II; D046911:Macromolecular Substances; D008285:Major Histocompatibility Complex; D051379:Mice; D001613:beta 2-Microglobulin / Q000235:genetics
D003062:Codon; D046911:Macromolecular Substances; D001613:beta 2-Microglobulin