Effects of a single oral dose of 3-cyano-imipramine on serotonin uptake and content of platelets in healthy volunteers.
Changes in platelet serotonin uptake and content were investigated following administration of a single oral dose of 3-cyano-imipramine to healthy volunteers. The uptake of 3H-serotonin by platelets harvested from these subjects was almost completely inhibited 4 h after dose administration. This inhibition continued for at least 24 h. Plasma taken from the subjects inhibited the uptake of 3H-serotonin by platelets isolated from non-treated subjects. A small but significant reduction in platelet serotonin content was observed 3.75 h after dosing and was still evident after 24 h.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D012701:Serotonin / Q000097:blood*; D013997:Time Factors
C024316:cianopramine; D012701:Serotonin; D007099:Imipramine