Enhancement of the antihypertensive effect of dietary n3- and n6-PUFA in SHR during a four-generation feeding period.
Feeding sunflower oil or linseed oil during a four-generation feeding period reduced hypertension development in spontaneously hypertensive rats most markedly in the 3rd and 4th generation. The hypotensive effects of the vegetable oils do not seem to be mediated via changes in aortic PGI2-like production.
D000818:Animals; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects*; D004041:Dietary Fats / Q000494:pharmacology*; D011464:Epoprostenol / Q000097:blood; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005260:Female; D006973:Hypertension / Q000517:prevention & control*; D008043:Linseed Oil; D008297:Male; D009821:Oils; D010938:Plant Oils; D011247:Pregnancy; D051381:Rats; D011918:Rats, Inbred SHR; D013329:Structure-Activity Relationship; D000074242:Sunflower Oil
D000959:Antihypertensive Agents; D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D009821:Oils; D010938:Plant Oils; D000074242:Sunflower Oil; D008043:Linseed Oil; D011464:Epoprostenol