The myxalamids, new antibiotics from Myxococcus xanthus (Myxobacterales). I. Production, physico-chemical and biological properties, and mechanism of action.
From the cell mass and culture supernatant of Myxococcus xanthus strain Mx X12 an antibiotic activity against yeasts, molds and some Gram-positive bacteria could be extracted. It consisted of 4 biologically active compounds which were named myxalamid A, B, C and D. The main component, myxalamid B, was shown to block in beef heart submitochondrial particles the respiratory chain at the site of complex I, i.e. NADH: ubiquinone oxidoreductase. The myxalamids are new antibiotics.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D001419:Bacteria / Q000187:drug effects; D002417:Cattle; D003580:Cytochromes / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism; D009231:Myxococcales / Q000254:growth & development*; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction; D011090:Polyenes / Q000302:isolation & purification / Q000633:toxicity; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D013367:Submitochondrial Particles / Q000187:drug effects / Q000378:metabolism
D000900:Anti-Bacterial Agents; D003580:Cytochromes; D011090:Polyenes; D009243:NAD; C039622:myxalamid A; C039623:myxalamid B; C039624:myxalamid C; C039625:myxalamid D