Assay of HBV DNA in the plasma of HBV-carrier chimpanzees superinfected with non-A, non-B hepatitis.
A dot hybridisation technique was used to monitor the levels of hepatitis B virus (HBV) DNA in the plasma of two HBV-carrier chimpanzees which had been inocula ed with documented infectious non-A, non-B hepatitis agents. A marked decrease in the quantity of HBV DNA in the plasma during the acute phase of the non-A, non-B hepatitis was observed in both carriers. The possible role of interferon or a similar antiviral agent in modulation of the HBV-carrier state is discussed. Hybridisation may become, in due course, the method of choice for examining blood samples for infectious hepatitis B virus.
D000818:Animals; D002353:Carrier State / Q000382:microbiology*; D004279:DNA, Viral / Q000097:blood*; D004259:DNA-Directed DNA Polymerase / Q000097:blood; D006509:Hepatitis B / Q000150:complications / Q000382:microbiology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000032:analysis; D006526:Hepatitis C / Q000150:complications / Q000382:microbiology*; D006525:Hepatitis, Viral, Human / Q000382:microbiology*; D009693:Nucleic Acid Hybridization; D002679:Pan troglodytes
D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D004259:DNA-Directed DNA Polymerase