Role of extradural and of general anaesthesia in fibrinolysis and coagulation after total hip replacement.
Thirty patients undergoing total hip replacement were randomly allocated to one of two groups. One group (n = 14) received extradural anaesthesia with 0.5% bupivacaine with adrenaline continued into the postoperative period (24 h) for pain relief. The other group (n = 16) received general anaesthesia with controlled ventilation, using nitrous oxide in oxygen and fentanyl i.v. Following surgery they received a narcotic analgesic i.m. on demand. Analysis of fibrinolysis inhibition activity and plasminogen activators revealed a significantly better fibrinolytic function in patients given continuous extradural anaesthesia than in those who received general anaesthesia followed by narcotics in the period after operation. Furthermore, the capacity for activation of factor VIII was significantly lower after operation in the former group.
D000368:Aged; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D001777:Blood Coagulation / Q000187:drug effects*; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010960:Plasminogen Activators / Q000378:metabolism; D013997:Time Factors
D005169:Factor VIII; D010960:Plasminogen Activators