The role of phosphoenolpyruvate in insulin secretion: the effect of L-phenylalanine.
Incubation of rat islets with phenylalanine increased the tissue content of phosophoenolpyruvate, both in the presence and in the absence of glucose. At the same time, L-phenylalanine neither stimulated nor inhibited insulin release. It is unlikely that insulin secretion is tightly coupled to the availability of phosphoenolpyruvate in rat islets.
D000409:Alanine / Q000494:pharmacology; D000818:Animals; D005947:Glucose / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010649:Phenylalanine / Q000494:pharmacology*; D010728:Phosphoenolpyruvate / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D010649:Phenylalanine; D010728:Phosphoenolpyruvate; D005947:Glucose; D000409:Alanine