Immunoactive peptides, FK-156 and FK-565. II. Restoration of host resistance to microbial infection in immunosuppressed mice.
The immunoactive peptides, FK-156 and its analogue, FK-565 were evaluated in various models of mice immunosuppressed with cyclophosphamide, hydrocortisone, mitomycin C, carrageenan and tumor cells. Treatment with FK-156 (subcutaneous) and FK-565 (oral) markedly restored host defense ability against microbial infection. The therapeutic effect of ticarcillin or gentamicin alone against pseudomonal infection in cyclophosphamide- and hydrocortisone-treated mice and tumor-bearing mice was much lower than in normal mice. The therapeutic effect of these antibiotics against pseudomonal infection in immunosuppressed mice was enhanced markedly by combined use with FK-156. The killing ability of macrophages and polymorphonuclear leukocytes of the immunosuppressed mice was also markedly enhanced by dosing with FK-156.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000599:Amino Acids, Diamino / Q000627:therapeutic use*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology; D001424:Bacterial Infections / Q000276:immunology*; D002351:Carrageenan / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology; D003960:Diaminopimelic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use*; D004357:Drug Synergism; D006854:Hydrocortisone / Q000494:pharmacology; D007113:Immunity, Innate; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D009842:Oligopeptides; D010587:Phagocytosis / Q000187:drug effects; D012510:Sarcoma 180 / Q000276:immunology
D000276:Adjuvants, Immunologic; D000599:Amino Acids, Diamino; D000903:Antibiotics, Antineoplastic; D008937:Mitomycins; D009842:Oligopeptides; D016685:Mitomycin; D003960:Diaminopimelic Acid; C034330:FK 156; D003520:Cyclophosphamide; D002351:Carrageenan; C039537:heptanoyl-gamma-D-glutamyl-L-meso-diaminopimelyl-D-alanine; D006854:Hydrocortisone