Transplacental transport of gold in rats exposed to sodium aurothiomalate.
The ultrastructural localization of gold in yolk sacs and fetuses from rats exposed to sodium aurothiomalate (Myocrisin, 25 mg/kg intraperitoneally) was examined by a photochemical technique. Gold was found in epithelial cells of the yolk sac and in hepatocytes of the fetuses. Ultrastructurally, gold was located in lysosome-like bodies. Gold was not detected in the kidney or the central nervous system of the fetuses. Maternal liver and kidney were included as controls for efficacy of gold treatment.
D000818:Animals; D005260:Female; D005333:Fetus; D006046:Gold / Q000378:metabolism*; D006052:Gold Sodium Thiomalate / Q000008:administration & dosage; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D015017:Yolk Sac / Q000378:metabolism
D006052:Gold Sodium Thiomalate; D006046:Gold