Levonorgestrel as a new radioligand for determination of sex hormone binding globulin in human plasma.
Levonorgestrel which binds with high affinity to SHBG, is suggested as a new radioligand for estimation of SHBG in human plasma. Using 3H-levonorgestrel as a ligand, a number of samples from men, women pregnant and non-pregnant were analysed. The SHBG content was lowest in men, low in women and rose to higher level during pregnancy. The results of the present study suggest that levonorgestrel appears to be a better ligand than dihydrotestosterone for measuring SHBG.
D003277:Contraceptives, Oral, Combined / Q000378:metabolism; D013196:Dihydrotestosterone / Q000378:metabolism; D005260:Female; D006801:Humans; D007700:Kinetics; D016912:Levonorgestrel; D008024:Ligands; D008297:Male; D009644:Norgestrel / Q000378:metabolism*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011263:Pregnancy Trimester, Third; D012737:Sex Factors; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism*; D013237:Stereoisomerism; D014316:Tritium
D003277:Contraceptives, Oral, Combined; D008024:Ligands; D012738:Sex Hormone-Binding Globulin; D013196:Dihydrotestosterone; D014316:Tritium; D009644:Norgestrel; D016912:Levonorgestrel