2-(6-carboxyhexyl)cyclopentanone hexylhydrazone. A potent and time-dependent inhibitor of platelet aggregation.
Two new azaprostanoids, a hydrazone (3) and hydrazide (4), have been prepared by the condensation of 2-(6-carboxyhexyl)cyclopentanone with n-hexylhydrazine and caproic acid hydrazide. Preliminary results with the stable hydrazide 4 indicate that it inhibits arachidonic acid (AA) induced human platelet aggregation and that, unlike 13-azaprostanoic acid (1), its site of action is at the cyclooxygenase level. Results with the unstable hydrazone derivative 3 indicate it to be a potent and time-dependent inhibitor of AA-induced human platelet aggregation, with its site of action also at the cyclooxygenase level.
D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D005227:Fatty Acids / Q000138:chemical synthesis*; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010974:Platelet Aggregation / Q000187:drug effects*; D011466:Prostanoic Acids / Q000138:chemical synthesis* / Q000494:pharmacology
D001095:Arachidonic Acids; D005227:Fatty Acids; D007202:Indicators and Reagents; D011466:Prostanoic Acids; D016718:Arachidonic Acid; C038576:2-(6-carboxyhexyl)cyclopentanone hexylhydrazone