A maximum likelihood estimate of the sex ratio of mutation rates in haemophilia A.
Carrier detection tests were carried out on 21 mothers of isolated cases of severe Haemophilia A, according to WHO recommendations. A maximum likelihood estimate of the male to female mutation ratio of 9.6 (95% confidence limits 2.2-41.5) was obtained.
D005169:Factor VIII / Q000032:analysis; D005260:Female; D006580:Genetic Carrier Screening; D006467:Hemophilia A / Q000097:blood / Q000235:genetics*; D006801:Humans; D008297:Male; D009154:Mutation; D011336:Probability; D012744:Sex Ratio
D005169:Factor VIII