Are elevated serum amyloid A levels and amyloid-enhancing factor sufficient to induce inflammation-associated amyloid deposition?
During inflammation-associated amyloidosis two coincident factors, serum amyloid A (SAA) and amyloid-enhancing factor (AEF) are apparently necessary for amyloid A (AA) deposition. It is shown by passive transfer of cytokines, which stimulate SAA production, and AEF that these are not sufficient. A further factor(s) is necessary, which stems from the acute inflammatory response. Potential candidates are serum or tissue glycosaminoglycans.
D000686:Amyloidosis / Q000209:etiology*; D000818:Animals; D001688:Biological Products / Q000378:metabolism; D002478:Cells, Cultured; D016207:Cytokines; D006023:Glycoproteins / Q000097:blood*; D006025:Glycosaminoglycans / Q000378:metabolism; D007249:Inflammation / Q000209:etiology; D008099:Liver / Q000378:metabolism; D008262:Macrophage Activation; D051379:Mice; D000685:Serum Amyloid A Protein / Q000378:metabolism*
D001688:Biological Products; D016207:Cytokines; D006023:Glycoproteins; D006025:Glycosaminoglycans; D000685:Serum Amyloid A Protein; C046748:amyloid enhancing factor