[Fundamental and clinical studies on T-1982 (cefbuperazone) in the field of obstetrics and gynecology].
T-1982 (cefbuperazone), a new cephamycin antibiotic, was fundamentally and clinically studied in the field of obstetrics and gynecology. The following results were obtained. The concentrations of T-1982 in arterial and venous blood and genitalia following intravenous injection were measured. The results demonstrated favourable transfer of the drug into various internal genital organs. T-1982 was administered to 12 patients. The efficacy rate was 75.0%, that is to say, good in 9 cases. No side effects were noted in any cases. It is, therefore, presumed that T-1982 is a useful drug for the infectious diseases in the field of obstetrics and gynecology although the number of subjects was not so large in this study.
D000328:Adult; D002513:Cephamycins / Q000378:metabolism* / Q000627:therapeutic use; D004716:Endometritis / Q000188:drug therapy / Q000382:microbiology; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D010053:Ovary / Q000378:metabolism; D000292:Pelvic Inflammatory Disease / Q000188:drug therapy; D014599:Uterus / Q000378:metabolism
D002513:Cephamycins; C035978:cefbuperazone