Bone marrow transplantation for severe aplastic anemia in Japan.
We surveyed cases of severe aplastic anemia treated by bone marrow transplantation from HLA-identical siblings according to information collected from 21 medical facilities throughout Japan. Twenty-nine patients have been given bone marrow transplants since 1977. Fifteen patients had survived for 20 to 2,485 days after bone marrow transplantation as of November 30, 1983. The one-year survival rate was 60% and the two-year survival rate was 44%. The incidence of rejection was 37% in patients with allogeneic bone marrow transplantation. Various regimens have been used for conditioning for bone marrow transplantation.
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000401:mortality / Q000628:therapy*; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006084:Graft Rejection; D006801:Humans; D007223:Infant; D007564:Japan; D008297:Male; D008875:Middle Aged; D014916:Whole-Body Irradiation
D000961:Antilymphocyte Serum; D003520:Cyclophosphamide