Macrophage procoagulants.
Monocytes and macrophages can be induced to produce tissue factor. Recent data suggest that macrophages make other products involved in the extrinsic coagulation pathway. These include vitamin K-dependent factors, factor X activators and a prothrombinase.
D000818:Animals; D001779:Blood Coagulation Factors / Q000096:biosynthesis*; D005165:Factor V / Q000096:biosynthesis; D005167:Factor VII / Q000096:biosynthesis; D005170:Factor X / Q000096:biosynthesis; D015951:Factor Xa; D006737:Horseshoe Crabs; D006801:Humans; D008262:Macrophage Activation; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D013925:Thromboplastin / Q000096:biosynthesis
D001779:Blood Coagulation Factors; C022475:prothrombinase complex; D005165:Factor V; D005167:Factor VII; D005170:Factor X; D013925:Thromboplastin; D015951:Factor Xa