Localization of [3H]N-propylnorapomorphine binding in mouse striatum.
The anatomic localization of specific striatal [3H]N-propylnorapomorphine ( [3H]PNA) binding was determined in male C57BL/6J mice. Striatal [3H]PNA binding was high affinity and sensitive to guanine nucleotides. Frontal cortical ablation did not alter striatal [3H]PNA binding, but reduced [3H]spiperone binding by 36%. Kainic acid reduced and 6-hydroxydopamine elevated [3H]PNA binding. A combined frontal cortical ablation and striatal kainic acid lesion was similar to that of kainate alone. These data are consistent with a localization of [3H]PNA binding sites on neurons intrinsic to the mouse striatum.
D000344:Afferent Pathways / Q000378:metabolism; D000818:Animals; D001058:Apomorphine / Q000031:analogs & derivatives* / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D005625:Frontal Lobe / Q000187:drug effects / Q000378:metabolism; D006892:Hydroxydopamines / Q000633:toxicity; D007608:Kainic Acid / Q000633:toxicity; D007700:Kinetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009434:Neural Pathways / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D016627:Oxidopamine; D011954:Receptors, Dopamine / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism
D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D013134:Spiperone; C009074:N-n-propylnorapomorphine; D016627:Oxidopamine; D001058:Apomorphine; D007608:Kainic Acid