[Cytobiochemical characteristics of the function of pulmonary alveolar macrophages during development of immune reactions after exposure to chemical air pollutants].
Based on an analysis of correlations between variation in the amount of alveolar macrophages of rat lungs and activity of enzymes localized in these cells (acid phosphatase, beta-galactosidase, beta-glucosidase, lactate dehydrogenase), the cytobiochemical changes in the function of pulmonary alveolar macrophages have been defined with the use of a model of permanent inhalation exposure to sulfur dioxide. The use of the model enables the dilimitation of the stages of defence-compensatory reactions and their transition to an unfavourable biological effect. The results obtained may serve as a theoretical basis for recommending a wider experimental application of the tests in question during regulation of environmental factors.
D000135:Acid Phosphatase / Q000378:metabolism; D000393:Air Pollutants / Q000009:adverse effects*; D000818:Animals; D002452:Cell Count; D004789:Enzyme Activation; D006651:Histocytochemistry; D007113:Immunity, Innate; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology; D008264:Macrophages / Q000276:immunology*; D011650:Pulmonary Alveoli / Q000201:enzymology / Q000276:immunology*; D051381:Rats; D013458:Sulfur Dioxide / Q000009:adverse effects; D001616:beta-Galactosidase / Q000378:metabolism; D001617:beta-Glucosidase / Q000378:metabolism
D000393:Air Pollutants; D013458:Sulfur Dioxide; D007770:L-Lactate Dehydrogenase; D000135:Acid Phosphatase; D001617:beta-Glucosidase; D001616:beta-Galactosidase
Tsitobiokhimicheskaia kharakteristika funktsional'nogo sostoianiia al'veoliarnykh makrofagov legkikh v protsesse razvitiia zashchitnykh reaktsiĭ organizma pri vozdeĭstvii khimicheskikh zagriazniteleĭ atmosfernogo vozdukha.