Genetic differences in the effect of ethanol on plasma corticosterone and nonesterified fatty acid in rats.
The influence of genotype on the responsiveness to ethanol in rodents was examined using biochemical measures. Nine different strains of rats were treated with saline or various doses of ethanol, and the changes in plasma corticosterone and of nonesterified free fatty acids were measured 1 hr later. It was found that the BUF/N strain of rats had the lowest response on both measures and also had the lowest blood ethanol levels. The most sensitive strains to ethanol were the ACI/N with respect to corticosterone, and WKY/N and M520/N with respect to nonesterified free fatty acids. The highest blood ethanol levels were seen in the MR/N and the WKY/N strains of rats.
D000437:Alcoholism / Q000097:blood / Q000235:genetics*; D000818:Animals; D003345:Corticosterone / Q000097:blood*; D004195:Disease Models, Animal; D000431:Ethanol / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005838:Genotype; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005230:Fatty Acids, Nonesterified; D000431:Ethanol; D003345:Corticosterone