A murine anti-I-Ak monoclonal antibody recognizes human DR (I-E-like) antigens.
A monoclonal antibody. H39-49.5, originally raised against the murine I-Ak antigen, recognizes a nonpolymorphic determinant on HLA-DR-like molecules from human cells. These HLA-DR-like molecules have been characterized by amino acid sequencing and have been found to be homologous to the murine I-E antigens rather than the murine I-A antigens. These results suggest a common origin for the murine I-E, I-A, and HLA-DR antigens and caution that serological cross-reactivity alone cannot be used to reliably establish the presence of structural homologues of I-E- or I-A-like molecules in other species.
D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D003429:Cross Reactions; D005802:Genes, MHC Class II; D006649:Histocompatibility Antigens / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D051379:Mice
D000911:Antibodies, Monoclonal; D006649:Histocompatibility Antigens; D000949:Histocompatibility Antigens Class II; C024138:I-E-antigen