Naloxone inhibits intermale aggression in isolated mice.
Aggression and thermal pain thresholds were measured in separate groups of isolated male mice following 0.2-5.0 mg/kg SC injections of the opiate antagonist naloxone. The drug inhibited aggressive behaviors dose-dependently, but had no effect on pain. These results suggest that endogenous opioid systems may be activated during repeated intermale aggressive encounters.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009270:Naloxone / Q000494:pharmacology*; D012934:Social Isolation
D009270:Naloxone