[Production of delayed-release formulations based on hydrophilic matrix forms using polyvinyl alcohol].
By increasing the drug concentration or the porosity of the mouldings, the liberation rate of the drug is increased. Dependently on their wetting behaviour and concentration, insoluble solids may exert varied effects on the liberation rate. The rate of swelling and, thus, the disintegration time and the release can be controlled by the addition of magnesium stearate or potato starch.
D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D008094:Lithium / Q000008:administration & dosage; D016651:Lithium Carbonate; D011142:Polyvinyl Alcohol; D011189:Potassium Chloride; D012969:Sodium Fluoride; D013229:Stearic Acids
D003692:Delayed-Action Preparations; D013229:Stearic Acids; D016651:Lithium Carbonate; C031183:stearic acid; D011189:Potassium Chloride; D012969:Sodium Fluoride; D011142:Polyvinyl Alcohol; D008094:Lithium
Zur Herstellung von Retardformlingen auf der Basis hydrophiler Matrixformen mit Hilfe von Polyvinylalkohol.