Cefoperazone against carbenicillin-resistant isolates of Pseudomonas aeruginosa: comparison with other newer cephalosporins and N-formimidoyl thienamycin.
The in-vitro activities of cefoperazone, cefotaxime, ceftriaxone, latamoxef (moxalactam), ceftazidime and N-formimidoyl-thienamycin (N-f-thienamycin) were compared against clinical isolates of Pseudomonas aeruginosa that were resistant to carbenicillin and gentamicin, or against those which were susceptible. N-f-thienamycin and ceftazidime were more active than cefotaxime, ceftriaxone and latamoxef only against carbenicillin-susceptible isolates: isolates resistant to carbenicillin exhibited markedly increased resistance to cefoperazone, but not to N-f-thienamycin or ceftazidime. A partial cross-resistance was observed between carbenicillin and cefoperazone. This was due to the presence in these Pseudomonas isolates of a plasmid-mediated beta-lactamase which was active against carbenicillin and cefoperazone but not against cefotaxime, ceftriazone and latamoxef.
D002228:Carbenicillin / Q000494:pharmacology*; D002438:Cefoperazone / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D003227:Conjugation, Genetic; D015378:Imipenem; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013845:Thienamycins / Q000494:pharmacology*; D001618:beta-Lactamases / Q000032:analysis
D002511:Cephalosporins; D013845:Thienamycins; D015378:Imipenem; D002438:Cefoperazone; D001618:beta-Lactamases; D002228:Carbenicillin