Exercise-induced changes of Factor VIII complex in healthy subjects and in type-I diabetics: relation between growth hormone and Von Willebrand Factor increments.
This work aims to study the exercise-induced changes of Factor VIII Complex both in healthy subjects and in type I diabetics without vascular complications, and to investigate the possible relations between growth hormone and Von Willebrand's Factor response to exercise. Results show that maximal exercise performed by cycle ergometer causes a significant increment of the procoagulant subunit (VIII:C) and of Von Willebrand Factor (VIII:RiCoF) both in healthy controls and in type I diabetics, whereas a slight increment of Factor VIII-Related antigen (VIIIR:Ag) is observed only in diabetics. The shape of the mean GH response to exercise parallels the one of Von Willebrand's Factor: however, the presence of VIII:RiCoF increments also in GH non-responders supports the conclusion that growth hormone is not the only factor involved in the regulation of Von Willebrand's Factor exercise-induced increase.
D000328:Adult; D001779:Blood Coagulation Factors / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D005169:Factor VIII / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000032:analysis; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D008297:Male; D005082:Physical Exertion; D011674:Pulse; D014841:von Willebrand Factor / Q000378:metabolism*
D001779:Blood Coagulation Factors; D001786:Blood Glucose; D005169:Factor VIII; D006442:Glycated Hemoglobin; D013006:Growth Hormone; D014841:von Willebrand Factor