A comparative study of several agents alone and combined in protection of the rodent kidney from warm ischaemia: methylprednisolone, propranolol, furosemide, mannitol, and adenosine triphosphate-magnesium chloride.
The effect of 60 min of in situ warm ischaemia (37 degrees C) on renal function was investigated in the rat model. In addition, the effect of pretreatment with intravenously administered furosemide, mannitol, propranolol, methylprednisolone, and adenosine triphosphate-magnesium chloride (ATP-MgCl2), singly or in combination, was studied. The ischaemic kidney was effectively protected by the administration of methylprednisolone alone but not by furosemide, mannitol, ATP-MgCl2, or propranolol singly or in combination. These results demonstrate that rat kidneys subjected to 60 min of warm ischaemia can be safely protected with methylprednisolone pretreatment (3 mg/100 g of body weight) 30 min before warm ischaemia.
D000255:Adenosine Triphosphate / Q000627:therapeutic use; D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D007511:Ischemia / Q000517:prevention & control*; D007668:Kidney / Q000098:blood supply; D016030:Kidney Transplantation; D008274:Magnesium / Q000627:therapeutic use; D015636:Magnesium Chloride; D008353:Mannitol / Q000627:therapeutic use; D008775:Methylprednisolone / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
D015636:Magnesium Chloride; D008353:Mannitol; D005665:Furosemide; D000255:Adenosine Triphosphate; D011433:Propranolol; D003404:Creatinine; D008274:Magnesium; D008775:Methylprednisolone