The effect of E-N-trimethyl lysine (TML) treatment on the regeneration of bone marrow and intestinal mucosa in mice.
E-N-Trimethyl-lysine (TML) prevents the anemia caused by 5 Gy whole body irradiation of mice when applied simultaneously with irradiation in a dose of 100 mg/kg i.p. The number of splenic colonies increases significantly after TML treatment of the irradiated recipients. TML increased the proliferative activity of Lieberkühn's crypts in mice, especially after lethal whole body irradiation. The possibility of clinical use of TML is discussed.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D005260:Female; D006400:Hematocrit; D007413:Intestinal Mucosa / Q000166:cytology / Q000187:drug effects*; D008239:Lysine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D008938:Mitosis / Q000187:drug effects; D012038:Regeneration / Q000187:drug effects*; D014916:Whole-Body Irradiation
C003712:trimethyllysine; D008239:Lysine