Abortion rate in pregnancies following ovulation induced by human menopausal gonadotropin/human chorionic gonadotropin.
Despite the high incidence of fetal loss following gonadotropin therapy, the etiologic, factors that contribute to this loss remain unknown. In 203 women who conceived following gonadotropin therapy, the abortion rate was 28.5%. However, in 84 women who conceived a second time, also with gonadotropin treatment, the abortion rate was 11.9%. Second- and third-degree hyperstimulation of the ovary are accompanied by a 50% abortion rate, and the occurrence of abortion is more frequent in the first pregnancy. The contribution of multiple pregnancy, maternal age, and number of gonadotropin treatment cycles are also evaluated and discussed.
D000022:Abortion, Spontaneous / Q000209:etiology*; D000328:Adult; D006063:Chorionic Gonadotropin / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008423:Maternal Age; D008596:Menotropins / Q000009:adverse effects / Q000627:therapeutic use*; D010053:Ovary / Q000187:drug effects; D010062:Ovulation Induction; D011247:Pregnancy; D011272:Pregnancy, Multiple; D013268:Stimulation, Chemical
D006063:Chorionic Gonadotropin; D008596:Menotropins