[Study of the template properties and protein composition of the products of postradiation degradation of chromatin in the rat thymus].
In order to verify the assumption that the products of postirradiation degradation of the chromatin originate mainly at the genome sites active in transcription a study was made of the template activity of PDN, its sensitivity to DNAase I, and the protein composition of individual PDN fractions: The radiation-induced chromatin degradation in lymphoid cells was shown to occur in both the active and the repressed genome sites.
D000818:Animals; D002843:Chromatin / Q000235:genetics / Q000378:metabolism / Q000528:radiation effects*; D002847:Chromatography, Agarose; D003850:Deoxyribonuclease I / Q000494:pharmacology; D004591:Electrophoresis, Polyacrylamide Gel; D006868:Hydrolysis; D008297:Male; D011089:Polydeoxyribonucleotides / Q000235:genetics / Q000378:metabolism* / Q000528:radiation effects; D051381:Rats; D013698:Templates, Genetic; D013950:Thymus Gland / Q000378:metabolism / Q000528:radiation effects*; D014158:Transcription, Genetic / Q000528:radiation effects; D014916:Whole-Body Irradiation
D002843:Chromatin; D011089:Polydeoxyribonucleotides; D003850:Deoxyribonuclease I
Issledovanie matrichnykh svoĭstv i belkovogo sostava produktov postradiatsionnoĭ degradatsii khromatina timusa krys.