Osteoarticular manifestations in sickle-cell disorders.
The osteoarticular manifestations of the main sickling disorders (homozygous sickle cell-HbSS anaemia-, double heterozygous-HbS-beta thalassaemia, double heterozygous HbS-C disease and sickle cell-trait) are reviewed; They may be grouped into 3 main categories: vaso-occlusive, infective and metabolic. The pathophysiology and pathogenesis as well as the treatment are discussed.
D000755:Anemia, Sickle Cell / Q000150:complications*; D001157:Arterial Occlusive Diseases / Q000209:etiology; D001847:Bone Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D006450:Hemoglobin SC Disease / Q000150:complications; D006801:Humans; D007592:Joint Diseases / Q000175:diagnosis / Q000209:etiology* / Q000628:therapy; D013789:Thalassemia / Q000150:complications; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid