Prostacyclin and DNA-synthesis inhibitors: their interaction on experimental gastric ulcer in the rat.
The protective effect of prostacyclin on gastric mucosal damage by indomethacin or restraint in rats was partly inhibited by DNA-synthesis inhibitors. Protection by prostacyclin may therefore depend upon intact DNA-synthesis.
D000818:Animals; D003561:Cytarabine / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis*; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D007213:Indomethacin / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological
D003561:Cytarabine; D004247:DNA; D011464:Epoprostenol; D007213:Indomethacin