[Chromosomal translocation (11; 22) in cell lines of Ewing's sarcoma].
Chromosome studies were performed on 5 Ewing sarcoma cell lines. An identical reciprocal translocation t(11; 22) (q24; q12) was found in 4 cell lines established from 3 different tumors. These results, associated with those obtained at the same time and independently from fresh tumor cells, suggest that the translocation t(11; 22)(q24; q12) may be a chromosomal marker characteristic of Ewing sarcoma cells. This translocation involves the chromosome 22 on which the H-c-sis oncogene has been located; it could be used as a new tool for exploring the role of genetic transposition in the malignant cell transformation.
D000328:Adult; D002460:Cell Line; D002648:Child; D002675:Child, Preschool; D002871:Chromosome Banding; D002904:Chromosomes, Human, 21-22 and Y; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D012512:Sarcoma, Ewing / Q000235:genetics*; D014178:Translocation, Genetic
Translocation chromosomique (11; 22) dans des lignées cellulaires de sarcomes d'Ewing.