High dose, low frequency parenteral gold administration.
A dosage plan of up to 200 mg of aurothioglucose at approximately 4-week intervals was tested. Moderate or major improvement occurred in 20 of the 30 patients entered. Mean erythrocyte sedimentation rate fell from 46 to 26 mm/h, mean grip strength rose from 99 to 179 mm Hg (best hand) and mean number of swollen joints declined from 10.9 to 3.3. Maximum improvement occurred at a mean cumulative dose of 649 mg and after an average of 18 weeks and 5 visits. These data suggest that more efficient strategies for gold administration can be devised.
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D006051:Aurothioglucose / Q000008:administration & dosage* / Q000627:therapeutic use; D001799:Blood Sedimentation; D004334:Drug Administration Schedule; D005260:Female; D006046:Gold / Q000008:administration & dosage*; D006801:Humans; D007273:Injections, Intramuscular; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D006051:Aurothioglucose; D006046:Gold