[Reactivity of the DOPA--dopamine--noradrenaline--adrenaline system in epileptics].
Epileptic patients were examined for the daily urine elimination of DOPA, dopamine (DA), noradrenaline (NA), and adrenaline (A). The changes in the excretion of these substances after L-DOPA intake and the adrenaline and insulin test were also investigated. In addition to the evidence about the preserved reactivity of the DOPA-DA-NA-A system to L-DOPA intake, data were obtained pointing to its strain and a reduction in the reserve potentialities. The use of the adrenaline test disclosed the absence of, or a negative response on the part of DA and A in half of the patients, which correlated with definite clinical parameters. In one third of the patients, the insulin test was not accompanied by any increase in the excretion of A or its precursors. The findings obtained are indicative of the insufficiency of homeostatic reactions in epileptics and, possibly, of the deficit of the repolarizing mechanisms.
D000293:Adolescent; D000328:Adult; D002395:Catecholamines / Q000652:urine*; D004295:Dihydroxyphenylalanine / Q000652:urine; D004298:Dopamine / Q000652:urine; D004828:Epilepsies, Partial / Q000652:urine; D004827:Epilepsy / Q000652:urine*; D004837:Epinephrine / Q000652:urine; D005260:Female; D006801:Humans; D007328:Insulin; D007980:Levodopa; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000652:urine
D002395:Catecholamines; D007328:Insulin; D007980:Levodopa; D004295:Dihydroxyphenylalanine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine
Reaktivnost' sistemy DOFA--dofamin--noradrenalin--adrenalin u bol'nykh épilepsieĭ.