Folate enzymes in Ehrlich ascites carcinoma-bearing mice.
The activity of 4 enzymes involved in the formation and interconversion of folate coenzymes has been examined in liver and kidney of healthy and Ehrlich ascites carcinoma-bearing mice. In the liver, a 50% increase of methylenetetrahydrofolate reductase activity was shown soon after tumour cell inoculation, while the activity of formyltetrahydrofolate synthetase and methylenetetrahydrofolate dehydrogenase decrease by 20% at an advanced stage of tumour development. In kidneys of the host mouse the only change observed was a decrease of dihydrofolate reductase activity. The levels of activity of all assayed enzymes found in host organs were similar to that in Ehrlich carcinoma cells.
D045103:5,10-Methylenetetrahydrofolate Reductase (FADH2); D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000201:enzymology*; D005260:Female; D005574:Formate-Tetrahydrofolate Ligase / Q000378:metabolism*; D007668:Kidney / Q000201:enzymology; D008025:Ligases / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP) / Q000378:metabolism*; D051379:Mice; D009368:Neoplasm Transplantation; D010088:Oxidoreductases / Q000378:metabolism*; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism*
D010088:Oxidoreductases; D000429:Alcohol Oxidoreductases; D045103:5,10-Methylenetetrahydrofolate Reductase (FADH2); D013762:Tetrahydrofolate Dehydrogenase; D008754:Methylenetetrahydrofolate Dehydrogenase (NADP); D008025:Ligases; D005574:Formate-Tetrahydrofolate Ligase