Diagnostic value of monitoring kinetics of antibody responses in candidiasis by a solid-phase radioimmunoassay.
A solid-phase radioimmunoassay was used to monitor antibody binding to cytoplasmic antigens of Candida albicans in sera from patients with superficial or deep-seated candidiasis over extended observation periods. Healthy persons showed a constant level of Candida antibodies. Patients with superficial candidiasis or colonization generally had a slow, but significant rise; patients with presumptive and proven systemic candidiasis, however, developed rapid rises (up to forty-fold) of antibody levels within a few days. This method permitted the kinetics of antibody response to be followed and, thus, appeared to aid in the differentiation among the various forms of candidiasis.
D000328:Adult; D000907:Antibodies, Bacterial / Q000276:immunology; D000908:Antibodies, Fungal / Q000276:immunology*; D000917:Antibody Formation; D002177:Candidiasis / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology; D011863:Radioimmunoassay / Q000379:methods*
D000907:Antibodies, Bacterial; D000908:Antibodies, Fungal; D007074:Immunoglobulin G