B-cell malignancies and differentiation antigens defined with monoclonal antibodies.
Monoclonal antibodies directed to B-cell lineage were produced. They were characterized by their reactivity with a variety of human hematopoietic cell lines and normal lymphoid cells and by the immunohistological distribution of cells positive for the antibodies. Some of them were specific for B-cell lineage at various stages of B-cell differentiation and some were, in addition, cross-reactive with other cell lineages. These newly produced antibodies were utilized to dissect and characterize B-cell malignancies and were applied for classification of B-cell malignancies.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000944:Antigens, Differentiation, B-Lymphocyte; D000951:Antigens, Neoplasm / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D001402:B-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D007938:Leukemia / Q000145:classification / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology*; D051379:Mice
D000911:Antibodies, Monoclonal; D000944:Antigens, Differentiation, B-Lymphocyte; D000951:Antigens, Neoplasm; D000954:Antigens, Surface