A mature myeloid antigen identified on human natural killer cells.
A rat monoclonal antibody (MAb), NIMP-R10, selected for binding to mouse granulocytes was found to identify all mature human peripheral blood neutrophils and a subpopulation of mononuclear cells. By cell sorting experiments the mononuclear cells labelled with NIMP-R10 were shown to be predominantly large granular lymphocytes encompassing most of the natural killer cell activity of peripheral blood cells. NIMP-R10 blocks the complement receptor on mouse myeloid cells, but the MAb was found to have no such biological activity when human cells were examined.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000302:isolation & purification*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D016177:Macrophage-1 Antigen; D009000:Monocytes / Q000276:immunology; D009504:Neutrophils / Q000276:immunology*; D051381:Rats; D011951:Receptors, Complement / Q000276:immunology
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D016177:Macrophage-1 Antigen; D011951:Receptors, Complement