Alcohol preference and voluntary alcohol intakes of inbred rat strains and the National Institutes of Health heterogeneous stock of rats.
The alcohol preference ratios and the daily free-choice ethanol intakes (10% ethanol versus water) of the newly constituted National Institutes of Health (NIH) heterogeneous stock (N/Nih) rats, and of the eight inbred strains from which N/Nih derived, were measured. Among the eight inbred strains, ACI/N, WKY/N, F344/N, BUF/N, BN/Ssn, WN/N, M520/N, and MR/N, the ACI exhibited the lowest preference and intakes and the MR and the M520 the highest. The mean values for the N/Nih animals were intermediate among those of the inbred strains. The range of intake for the N/Nih rats was 0.06-9.5 g/kg of body weight/day, indicating that they should serve as an appropriate foundation in selection studies for alcohol-drinking preference.
D000428:Alcohol Drinking; D000437:Alcoholism / Q000235:genetics*; D000818:Animals; D003433:Crosses, Genetic; D004195:Disease Models, Animal; D005838:Genotype; D006801:Humans; D051381:Rats; D011919:Rats, Inbred Strains