In vitro testing for cancer-causing chemicals.
Of all the chemicals present in our environment, which cause cancer and which do not? Since whole-animal bioassays are too expensive and time-consuming for routine screening, attention has focused on short-term in vitro and in vivo tests that generally demonstrate mutagenesis or other forms of chemical interaction with DNA. Merits and limitations of these tests are discussed.
D000818:Animals; D001482:Base Composition; D002273:Carcinogens / Q000494:pharmacology*; D004261:DNA Replication / Q000187:drug effects; D005260:Female; D051379:Mice; D009152:Mutagenicity Tests; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects*; D012854:Sister Chromatid Exchange / Q000187:drug effects
D002273:Carcinogens