A correlation analysis between bone formation rate and bioelectric potentials in rabbit tibia.
The origin of the bioelectric potentials in unstressed living bones is still an open question. Blood-flow in vessels, stationary potentials on peripheral nerves, muscle injury potentials, and viability of bone cells are claimed to be possible sites of origin of the electric potentials recorded on bone surface. The present data show that the topographic quantitative distribution of tetracycline labeling at sequential levels of rabbit tibia and the distribution pattern of the bioelectric potentials in this bone are significantly superimposable. This coincidence of bone formation rates and bioelectric potentials seems to support the view that the latter are in some way linked with the laying down of new bone.
D000200:Action Potentials; D000818:Animals; D001846:Bone Development; D001842:Bone and Bones / Q000502:physiology*; D003707:Demeclocycline; D005260:Female; D008297:Male; D010012:Osteogenesis; D011817:Rabbits; D013977:Tibia / Q000254:growth & development / Q000502:physiology
D003707:Demeclocycline