Interference with human memory by an antibiotic.
Thirty-two volunteers learned a sentence after awakening from early in the first REM period of sleep and recalled it after awakening from the third REM period, under experimental conditions that controlled for state dependency. The tetracycline antibiotic doxycycline (200 mg), taken at bedtime, impaired recall possibly through a putative inhibitory action on brain protein synthesis.
D000328:Adult; D004318:Doxycycline / Q000134:cerebrospinal fluid / Q000494:pharmacology*; D006801:Humans; D008568:Memory / Q000187:drug effects*; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D004318:Doxycycline