[Combined Staphylococcus-Proteus-Pseudomonas vaccine. II. The toxicity of the vaccine in "chronic" experiments and its ability to protect animals against Proteus and Staphylococcus infections].
The combined preparation consisting of the antigenic complexes of staphylococci (1 part), Proteus (1 part) and P. aeruginosa parts) was capable of protecting mice from infection with staphylococci, Proteus and P. aeruginosa and prolonging the survival time of rabbits under the conditions of the development of staphylococcal sepsis. The staphylococcal component of the combined preparation possessed adjuvant activity, increasing the immunogenicity of Proteus antigen. The combined vaccine enhanced a short-time increase in the nonspecific resistance of the animals. The moderate toxicity of the preparation permits making multiple injections of the preparation to mice without inhibiting the weight gain of the animals.
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001428:Bacterial Vaccines / Q000633:toxicity*; D002908:Chronic Disease; D004338:Drug Combinations; D007113:Immunity, Innate / Q000187:drug effects; D007114:Immunization / Q000379:methods; D051379:Mice; D011512:Proteus Infections / Q000517:prevention & control*; D011514:Proteus vulgaris / Q000276:immunology*; D011552:Pseudomonas Infections / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D013209:Staphylococcal Vaccines / Q000633:toxicity*; D013997:Time Factors; D014774:Virulence
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D004338:Drug Combinations; D013209:Staphylococcal Vaccines
Assotsiirovannaia stafiloproteĭno-psevdomonas vaktsina. Soobshchenie II. Toksichnost' vaktsin v "khronicheskikh" opytakh i ee sposobnost' zashchishchat' zhivotnykh ot zarazheniia proteem i stafilokokkom.