Initiation of DNA synthesis in quiescent Swiss 3T3 and 3T6 cells by lanthanum.
La3+ stimulated quiescent Swiss 3T3 and 3T6 cells to enter the DNA-synthesizing S phase of the cell cycle. La3+ and insulin interacted synergistically to increase DNA synthesis. A brief exposure of the cells to soluble LaCl3 optimally stimulated entry into S. La3+ was similar to A13+ in its mitogenic properties (J. Cell. Physiol. 118, 298, 1984), but La3+ was 10 times more potent than A13+.
D000535:Aluminum / Q000494:pharmacology; D000818:Animals; D002478:Cells, Cultured; D003078:Colchicine / Q000494:pharmacology; D004261:DNA Replication / Q000187:drug effects*; D007328:Insulin / Q000494:pharmacology; D007399:Interphase / Q000187:drug effects; D007700:Kinetics; D007811:Lanthanum / Q000494:pharmacology*; D051379:Mice
D007328:Insulin; D007811:Lanthanum; D000535:Aluminum; D003078:Colchicine