title: Primary biliary cirrhosis, dark adaptometry, electro-oculography, and vitamin A state.
abstract: Twenty five patients with primary biliary cirrhosis were studied for vitamin A state. In nine patients found to have low circulating vitamin A concentrations no abnormality was found on electro-oculography or in dark adaptation. A positive correlation was found between retinol binding protein and vitamin A values (r = +0.88; p less than 0.001) and between serum albumin and vitamin A values (r = +0.75; p less than 0.001). A weaker and negative correlation was found between serum bilirubin (r = -0.47; p less than 0.05) and vitamin A values. Patients with primary biliary cirrhosis should not receive regular parenteral or even oral vitamin A supplementation unless dark adaptometry or electrooculography yields an abnormal result.
mesh_terms: D003623:Dark Adaptation; D004585:Electrooculography; D005123:Eye / Q000503:physiopathology*; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000097:blood* / Q000503:physiopathology; D014801:Vitamin A / Q000097:blood* / Q000627:therapeutic use
chemical_list: D014801:Vitamin A