title: Antibiotic susceptibility pattern and capsular types of Haemophilus influenzae recovered from clinical specimens in northern Norway.
abstract: One hundred and nine strains of Haemophilus influenzae recovered from clinical specimens were examined for antibiotic sensitivity pattern and capsular types. All strains from blood cultures, cerebrospinal fluid and a joint aspirate were type b whereas most of the isolates were acapsular when recovered from other specimens viz. wound secretions (67%), maxillary sinus (75%), lower resp tract (86%), nasal cavity (90%). Out of the 109 strains 88 (81%) were non-typable, and 3.6% were beta-lactamase-producing, two of which were type e, one was type b and one was acapsular. Three beta-lactamase-producing strains were isolated from specimens from the respiratory tract and one from blood cultures. Beta-lactamase-producing strains including one chloramphenicol-resistant strain harboured similar plasmids, as judged by agarose gel electrophoresis. The strains showed quite a uniform sensitivity to antibacterial agents with the exception of sulphonamides to which the capsular strains, particularly type b strains, were less susceptible.
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology; D006192:Haemophilus Infections / Q000382:microbiology*; D006193:Haemophilus influenzae / Q000145:classification / Q000187:drug effects*; D006801:Humans; D009664:Norway; D010400:Penicillin G / Q000494:pharmacology; D010404:Penicillin V / Q000494:pharmacology; D010957:Plasmids; D011135:Polysaccharides, Bacterial / Q000145:classification*; D013443:Sulfisomidine / Q000494:pharmacology; D013449:Sulfonamides / Q000494:pharmacology; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D011135:Polysaccharides, Bacterial; D013449:Sulfonamides; D002701:Chloramphenicol; D000667:Ampicillin; D001618:beta-Lactamases; D010400:Penicillin G; D013443:Sulfisomidine; D010404:Penicillin V