title: [Cooperation of B- and T-lymphocytes of the human in vitro and in vivo].
abstract: It is reported on the experimental proofs for the existence of a cooperation of different populations of lymphocytes in man. Regulatory lymphocytes play a part in the regulation of the synthesis of immunoglobulins by polyclonally stimulated B-lymphocytes, in the generation of killer-T-cells and in the regulation of the DNA-synthesis by mitogenically stimulated T- and B-cells. Typical helper- and suppressor-effects may be proved. Disturbances of lymphocytic interactions may be a cause for the development of immune deficiency diseases. It is very probable that also in several chronic infections a dysfunction of regulatory T-lymphocytes is present.
mesh_terms: D001327:Autoimmune Diseases / Q000473:pathology; D001402:B-Lymphocytes / Q000502:physiology*; D004247:DNA / Q000096:biosynthesis; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000096:biosynthesis; D007153:Immunologic Deficiency Syndromes / Q000473:pathology; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000502:physiology; D037102:Lectins / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects; D008211:Lymphocyte Cooperation; D013601:T-Lymphocytes / Q000502:physiology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
chemical_list: D007136:Immunoglobulins; D037102:Lectins; D004247:DNA
vernacular_title: Kooperation von B- und T-Lymphozyten des Menschen in vitro und in vivo.