Immunomodulation by Bacillus subtilis spores.
This study was undertaken in order to investigate the immunomodulatory effect of heat-killed Bacillus subtilis spores as well as of one soluble and one insoluble fraction obtained after their mechanical breakage. The results demonstrate that heat-killed spores, the soluble and the insoluble fraction enhance the primary PFC response to T-dependent antigens such as SRBC and HRBC, but not to T-independent antigens such as Ficoll-TNP. However, the same doses capable of enhancing the production of antibodies against T-dependent antigens were unable to modify the host CMI, evaluated in terms of contact sensitivity to oxazolone.
D000818:Animals; D000917:Antibody Formation; D000955:Antigens, T-Independent; D001412:Bacillus subtilis; D004912:Erythrocytes; D005362:Ficoll / Q000494:pharmacology; D006736:Horses; D007111:Immunity, Cellular; D051379:Mice; D012756:Sheep; D013171:Spores, Bacterial; D014301:Trinitrobenzenes / Q000494:pharmacology
D000955:Antigens, T-Independent; D014301:Trinitrobenzenes; D005362:Ficoll