Noncollagenous proteins in normal and pathological human bone.
The concentrations of alpha 2HS-glycoprotein, albumin, and sialic acid were measured in the bone of 28 normal individuals and 6 patients with osteogenesis imperfecta, 3 patients with Paget's disease, and 4 patients with either renal osteodystrophy, osteoporosis, osteomalacia, or osteopetrosis. The concentration of alpha 2HS-glycoprotein in neonatal bone was 3 X higher than in bone from children and 7 X higher than in adult bone. The concentrations of albumin and sialic acid in neonatal bone were 1.5 X higher that in bone from children and twice the levels in adult bone. The concentrations of alpha 2HS-glycoprotein, albumin and sialic acid were above the normal mean values in the patients with osteogenesis imperfecta, and 4 patients had significantly raised levels of one or more of these proteins. The concentrations of these noncollagenous proteins were also significantly raised in Paget's disease, and the alpha 2HS-glycoprotein was significantly raised in renal osteodystrophy. The lowest level of alpha 2HS-glycoprotein was in osteopetrotic bone and the lowest levels of albumin and sialic acid were in osteoporotic bone. The results of this study suggest that the concentrations of alpha 2HS-glycoprotein, albumin, and sialic acid in bone are related to the rate of bone turnover.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D000418:Albumins / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism*; D001847:Bone Diseases / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000378:metabolism; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid; D010001:Osteitis Deformans / Q000378:metabolism; D010013:Osteogenesis Imperfecta / Q000378:metabolism; D010018:Osteomalacia / Q000378:metabolism; D010022:Osteopetrosis / Q000378:metabolism; D010024:Osteoporosis / Q000378:metabolism; D012794:Sialic Acids / Q000378:metabolism*; D060749:alpha-2-HS-Glycoprotein
C556354:AHSG protein, human; D000418:Albumins; D001798:Blood Proteins; D012794:Sialic Acids; D060749:alpha-2-HS-Glycoprotein; D019158:N-Acetylneuraminic Acid