[Effect of an antiglucocorticoid steroid on the arterial hypertension induced by glucocorticoids in the rat].
Hypertension was induced in male rats by administration of a glucocorticoid agonist, RU 26988. Systolic blood pressure (SBP) increased by 35 mmHg. Administration of an antimineralocorticoid derivative, RU 28318, did not modify hypertension. In contrast administration of a steroid derivative with antiglucocorticoid properties, RU 38486, prevented glucocorticoid-induced hypertension in a large part. SBP augmented only by 10 mmHg. The glucocorticoid increased total and active, ouabain-sensitive, 22Na efflux, as measured from caudal arteries, whereas concomitant administration of the antiglucocorticoid derivative prevented these changes. It is suggested that glucocorticoid-induced hypertension may be related to vascular Na pump activation and to the subsequent ionic changes. These changes, as well as hypertension, are antagonized by steroid derivatives with antiglucocorticoid properties.
D000732:Androstanols / Q000037:antagonists & inhibitors / Q000633:toxicity; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004963:Estrenes / Q000494:pharmacology; D005938:Glucocorticoids / Q000037:antagonists & inhibitors / Q000633:toxicity*; D006973:Hypertension / Q000139:chemically induced*; D008297:Male; D015735:Mifepristone; D008901:Mineralocorticoids / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism; D013148:Spironolactone / Q000031:analogs & derivatives / Q000494:pharmacology
D000732:Androstanols; D004963:Estrenes; D005938:Glucocorticoids; D008901:Mineralocorticoids; D013148:Spironolactone; D015735:Mifepristone; C038341:RU 26988; C041006:RU 28318; D012964:Sodium
Effet d'un stéroïde antiglucocorticoïde sur l'hypertension artérielle induite par les glucocorticoïdes chez le rat.