Elevation of serum prolactin acutely after administration of p-chloroamphetamine in rats.
p-Chloroamphetamine hydrochloride (0.5-10 mg/kg, i.p.) caused a rapid (within 30 minutes), dose-related increase in serum prolactin concentration in male rats. The effect was antagonized by pretreatment with p-chlorophenylalanine, an inhibitor of serotonin synethesis, or by metergoline, a serotonin receptor antagonist. The acute elevation of serum prolactin may have been mediated by the release of serotonin by p-chloroamphetamine.
D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D010134:Fenclonine / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D008711:Metergoline / Q000494:pharmacology; D011388:Prolactin / Q000097:blood*; D051381:Rats; D010133:p-Chloroamphetamine / Q000494:pharmacology*
D000662:Amphetamines; D008711:Metergoline; D010133:p-Chloroamphetamine; D011388:Prolactin; D010134:Fenclonine