Studies on the pharmacologic manipulation of suppressor cells associated with impaired immunoglobulin production.
Several agents were tested for their potential to reverse the suppression of normal IgG and IgM production mediatd by human cord T cells and cells from patients with agammaglobulinemia. No reversal of suppression was observed with in vitro incubation of co-cultured normal and immune-deficiency suppressor cells with cimetidine, lithium, or levamisole. Allogeneic helper factor prepared from normal mononuclear cells was able to overcome the suppression of normal IgG production mediated by cord T cells but did not overcome suppression of IgG or IgM production mediated by suppressor cells from agammaglobulinemic patients.
D000361:Agammaglobulinemia / Q000276:immunology; D002927:Cimetidine / Q000494:pharmacology; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis*; D007978:Levamisole / Q000494:pharmacology; D008094:Lithium / Q000494:pharmacology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007978:Levamisole; D002927:Cimetidine; D008094:Lithium