title: A microbiological evaluation of apalcillin.
abstract: The in vitro activity of apalcillin was tested against 350 clinical isolates of Escherichia coli, Enterobacter, Klebsiella, Proteus, Pseudomonas aeruginosa and Streptococcus faecalis. Using a minimal inhibitory concentration of 16 mg/l as the breakpoint, only 19.7% of the strains were resistant to apalcillin. A regression analysis demonstrated that it is possible to test bacteria for sensitivity with a 20 micrograms apalcillin disc. The results on Mueller-Hinton agar are very similar to those on Iso-Sensitest medium. Like other ureido penicillins, apalcillin is sensitive to most beta-lactamases; it is effective against ampicillin-resistant strains since it penetrates the outer membrane of gram-negative bacteria well and is highly effective against target proteins. Strains producing high amounts of beta-lactamases do become resistant to apalcillin.
mesh_terms: D000667:Ampicillin / Q000031:analogs & derivatives* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000382:microbiology; D004754:Enterobacter / Q000187:drug effects; D013293:Enterococcus faecalis / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009287:Naphthyridines; D011511:Proteus / Q000187:drug effects; D011513:Proteus mirabilis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013045:Species Specificity
chemical_list: D009287:Naphthyridines; C012122:apalcillin; D000667:Ampicillin