Platelet lysosomal enzymes are normal in myeloproliferative disorders.
In platelets of subjects affected with myeloproliferative disorders the following lysosomal enzymes were studied: alpha-mannosidase, alpha-fucosidase, beta-galactosidase, beta-glucosidase, beta-glucuronidase, beta-N-acetylglucosaminidase and acid phosphatase. For each enzyme the specific activity, the optimum of pH and buffer, Km and saturating substrate concentrations, as well as thermostability were determined. Control and patient enzymes showed no difference.
D001792:Blood Platelets / Q000201:enzymology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D007951:Leukemia, Myeloid / Q000201:enzymology; D008247:Lysosomes / Q000201:enzymology*; D009196:Myeloproliferative Disorders / Q000097:blood / Q000201:enzymology*; D011087:Polycythemia Vera / Q000201:enzymology; D013921:Thrombocytopenia / Q000201:enzymology