Antiinflammatory agents. 3. Synthesis and pharmacological evaluation of 2-amino-3-benzoylphenylacetic acid and analogues.
A series of substituted derivatives of 2-amino-3-benzoylphenylacetic acid (amfenac) has been synthesized and evaluated for antiinflammatory, analgesic, and cyclooxygenase inhibiting activity. Several derivatives including 157 (4'-chloro), 158 (4'-bromo), and 182 (5-chloro, 4'-bromo) were more potent than indomethacin in these assays.
D000698:Analgesia; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D001169:Arthritis, Experimental / Q000188:drug therapy; D055598:Chemical Phenomena; D002621:Chemistry; D016861:Cyclooxygenase Inhibitors; D005260:Female; D007213:Indomethacin / Q000627:therapeutic use; D007422:Intestines / Q000187:drug effects; D007536:Isomerism; D008297:Male; D010648:Phenylacetates / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D016861:Cyclooxygenase Inhibitors; D010648:Phenylacetates; C014285:amfenac; D007213:Indomethacin