Expression of HLA-DR antigens and cell proliferation in acute lymphoblastic leukemia of children.
Non-T, non-B acute lymphoblastic leukemia (ALL) in children can be further subdivided into common, null/undifferentiated and pre-B ALL. The overall labelling indices (LI) showed comparable values for these 3 subtypes of ALL. By sequential immunological, cytochemical and cytokinetic studies on single bone marrow cells, combined with morphological evaluation, blast cells could be attributed to the compartments of E-Ia+sIgM- and E-Ia-sIgM- cells, in pre-B/B ALL also to the compartment of E-Ia+sIgM+ cells. In all 30 patients investigated, the LI of Ia+ blast cells was higher than the LI of Ia- blast cells (p less than 0.001). However, no correlation between the percentage of Ia+ blast cells and the overall LI could be found in these patients (r = 0.284; p greater than 0.1).
D000911:Antibodies, Monoclonal / Q000276:immunology; D001854:Bone Marrow Cells; D002455:Cell Division; D002648:Child; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000145:classification* / Q000473:pathology; D008214:Lymphocytes / Q000145:classification*; D014411:Neoplastic Stem Cells / Q000145:classification; D012397:Rosette Formation
D000911:Antibodies, Monoclonal; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II