Lithium-carbamazepine neurotoxicity and risk factors.
Five rapid-cycling manic patients developed neurotoxic syndromes when treated with a combination of lithium and carbamazepine, although all five had therapeutic plasma levels of both drugs. The risk factors for development of neurotoxicity with this drug combination are discussed.
D000328:Adult; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D002220:Carbamazepine / Q000009:adverse effects*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008094:Lithium / Q000009:adverse effects*; D016651:Lithium Carbonate; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced*; D012306:Risk
D016651:Lithium Carbonate; D002220:Carbamazepine; D008094:Lithium