Studies on the etiologic mechanism of anisakiasis. --1. Immunological reactions of digestive tract induced by Anisakis larva.
In an attempt to determine the etiological mechanism of anisakiasis, immunological studies were performed using guinea pigs and rabbits. In order to carry out these examinations, we used a specific antigen, hemoglobin of Anisakis larva. We demonstrate that the etiological mechanism of anisakiasis involves anaphylactic reaction as well as Arthus reaction in the digestive tract. Cell-mediated immune reaction also have to consider the relation of establishment of allergic condition in experimental anisakiasis. These results suggest that the three types allergic reaction may play the main role in clinical symptomes of human anisakiasis.
D000707:Anaphylaxis / Q000209:etiology; D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000032:analysis; D001183:Arthus Reaction; D001199:Ascaridoidea / Q000276:immunology*; D004064:Digestive System / Q000276:immunology*; D006168:Guinea Pigs; D006454:Hemoglobins / Q000276:immunology; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D007814:Larva; D008264:Macrophages / Q000276:immunology; D009349:Nematode Infections / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D011817:Rabbits; D013270:Stomach / Q000473:pathology
D000941:Antigens; D006454:Hemoglobins