An attempt to correlate an idiotype with antibody structure.
The expression of different idiotypic families encountered in the anti-phosphorylcholine antibodies depends on the association of a heavy chain with one of the VL sub-families. Manipulation of the response by idiotypic suppression leads to formation of a T15cr family whose structural correlates are analysed by determination of the mRNA sequence of hybridoma heavy and light chains.
D000818:Animals; D000916:Antibody Diversity; D007143:Immunoglobulin Heavy Chains / Q000032:analysis; D007130:Immunoglobulin Idiotypes / Q000032:analysis* / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D009194:Myeloma Proteins / Q000032:analysis; D010767:Phosphorylcholine / Q000276:immunology; D012333:RNA, Messenger / Q000032:analysis
D007143:Immunoglobulin Heavy Chains; D007130:Immunoglobulin Idiotypes; D009194:Myeloma Proteins; D012333:RNA, Messenger; D010767:Phosphorylcholine