[Comparative study of circadian changes of the mortality of mice with respect to 2 aminoglycosides, gentamycin and dibekacin].
We compare the acute toxicity of a dose of gentamicin or dibekacin in Mice at different times of the day. The female Mice are housed with food and water ad libitum for one and half week, ten or fifteen per cage in a light controlled room (lights on from 8 to 20 hrs). Each animal was given gentamycin (250, 275, 300 or 325 mg/kg) intramuscular and dibekacin (320, 355, 390, 425 or 460 mg/kg) at one of four times: 8, 14, 20 and 2 hrs). After injection, the animals are kept in their cages and observed for 10 days. We show that the circadian biosusceptibility rhythm in dibekacin toxicity is similar to that of gentamycin with significant differences in the mortality at the four hours. There is an evident parallelism between the curves for gentamycin and dibekacin but the differences in the percentage of mortality rate are more important for gentamycin than for dibekacin.
D000818:Animals; D002940:Circadian Rhythm; D003982:Dibekacin / Q000633:toxicity*; D005260:Female; D005839:Gentamicins / Q000633:toxicity*; D007612:Kanamycin / Q000031:analogs & derivatives*; D051379:Mice
D005839:Gentamicins; D003982:Dibekacin; D007612:Kanamycin
Etude comparative des variations circadiennes de la mortalité de la souris vis-à-vis de deux aminoglycosides, la gentamicine et la dibekacine.