[Presence of high concentrations of aluminum in neurons of a patient dying from a rapidly developing dementia].
Ultrastructural observation of brain cells of a patient dead from senile dementia associated with myoclonies, has shown a number of intracytoplasmic dense structures. High concentration of Aluminium has been detected in these structures by electron probe X ray analysis. The clinical symptomatology, the evolution and the cell pathology observed in this patients are very similar to the classical features observed in dialysis encephalopathy the origin of which is an aluminium intoxication. In this patient, the possible origin of the intoxication is the absorption in the last 10 years of aluminium gels.
D000368:Aged; D000535:Aluminum / Q000032:analysis / Q000506:poisoning*; D001921:Brain / Q000378:metabolism; D001927:Brain Diseases / Q000139:chemically induced; D003704:Dementia / Q000139:chemically induced*; D004577:Electron Probe Microanalysis; D006801:Humans; D008297:Male; D009474:Neurons / Q000032:analysis*; D013997:Time Factors
D000535:Aluminum
Sur la présence d'aluminium en forte concentration dans les neurones d'un malade décédé d'une démence rapidement évolutive.