title: [Structural changes in muscle fiber contractile proteins studied by polarization ultraviolet fluorescence microscopy. VIII. The effect of glutaraldehyde and phalloidine on F-actin conformation].
abstract: Conformational changes in F-actin, induced by glutaraldehyde or phalloidin, were found in glycerinated m. psoas rabbit fibres (ghost and reconstructed fibres). It is shown that the conformational changes of F-actin decreased the thin filament flexibility as well as weakened fibre's contractility. It is assumed that the stabilization in F-actin structure may be an important factor involved in the mechanism of muscle contraction regulation.
mesh_terms: D000199:Actins / Q000032:analysis*; D000255:Adenosine Triphosphate / Q000494:pharmacology; D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D004347:Drug Interactions; D005976:Glutaral / Q000494:pharmacology*; D008856:Microscopy, Fluorescence; D008859:Microscopy, Polarization; D008860:Microscopy, Ultraviolet; D009119:Muscle Contraction / Q000187:drug effects; D009124:Muscle Proteins / Q000032:analysis*; D009132:Muscles / Q000187:drug effects / Q000648:ultrastructure*; D009842:Oligopeptides / Q000494:pharmacology*; D010590:Phalloidine / Q000494:pharmacology*; D011487:Protein Conformation / Q000187:drug effects; D011817:Rabbits
chemical_list: D000199:Actins; D000447:Aldehydes; D009124:Muscle Proteins; D009842:Oligopeptides; D010590:Phalloidine; D000255:Adenosine Triphosphate; D005976:Glutaral
vernacular_title: Izuchenie strukturnykh izmeneniĭ sokratitel'nykh belkov myshechnogo volokna s pomoshch'iu poliarizatsionnoĭ ul'trafioletovoĭ fluorestsentnoĭ mikroskopii. VIII. Vliianie glutaral'degida i falloidina na konformatsiiu F-aktina.