In vitro effects of skin lipid extracts on skin bacteria in relation to age and acne changes.
Skin lipid extracts of 185 persons of different age were tested in vitro against single representatives of skin bacteria: Staphylococcus aureus, S. epidermidis, Propionibacterium acnes, P. granulosum and Corynebacterium sp. in order to find differences in their inhibitory effects. Percentages of the extracts inhibiting the first 4 bacteria were nearly the same (about 20%) while corynebacteria were inhibited by only 3 extracts. Extracts showing these properties were isolated mainly from adolescents with acne changes, young adults, about 20 yr old, and from children 8--10 yr old, but not from elderly people. The age-related differences in growth inhibition may be related to known differences in relative composition of the sebum constituents according to age. Forty-two extracts of acne patients and healthy adults and adolescents showed an inverse effect in vitro: they enhanced bacterial growth. Growth enhancement was demonstrated only for P. granulosum.
D000152:Acne Vulgaris / Q000503:physiopathology*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001419:Bacteria / Q000187:drug effects*; D002648:Child; D003352:Corynebacterium / Q000187:drug effects; D005260:Female; D006131:Growth Inhibitors / Q000032:analysis*; D006801:Humans; D066298:In Vitro Techniques; D008055:Lipids / Q000494:pharmacology*; D008297:Male; D011425:Propionibacterium acnes / Q000187:drug effects; D012629:Sebum / Q000032:analysis; D012867:Skin / Q000032:analysis* / Q000503:physiopathology; D013211:Staphylococcus aureus / Q000187:drug effects
D006131:Growth Inhibitors; D008055:Lipids