[Regional distribution of enkephalinase in the rat brain by autoradiography].
The first visualization of enkephalinase (neutral metalloendopeptidase, E.C.3.4.24.11) in rat brain was obtained by autoradiography, using a new tritiated inhibitor: [3H]N-[( R,S )3-(N-hydroxy) carboxamido-2-benzyl propanoyl]glycine (3H-HCBP-Gly). The preliminary analysis of sections clearly showed a discrete localization of enkephalinase in enkephalin enriched regions, such as caudate nucleus, putamen, globus pallidus, and substantia nigra. Moreover 3H-HCBP-Gly binding also occurred in choroid plexus and spinal cord.
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000201:enzymology*; D001923:Brain Chemistry; D010450:Endopeptidases / Q000378:metabolism*; D015260:Neprilysin; D051381:Rats; D014018:Tissue Distribution
D010450:Endopeptidases; D015260:Neprilysin
Distribution régionale de l'enképhalinase dans le cerveau du rat par autoradiographie.