Types of disease and models for their genetic analysis.
The authors compare schizophrenia with several other diseases and discuss how a few simple models that have already been successfully applied in other cases could be used in the genetic analysis of schizophrenia and MAO activity. Among the diseases discussed are Huntington's disease, xanthomatosis, and diabetes. The authors recommend undertaking multivariate studies of monoamine oxidase, dopamine beta-hydroxylase, and other traits associated with schizophrenia in single, large pedigrees ascertained through schizophrenic probands.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D002874:Chromosome Mapping; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D006816:Huntington Disease / Q000235:genetics; D007223:Infant; D008875:Middle Aged; D008962:Models, Theoretical; D008995:Monoamine Oxidase / Q000097:blood*; D010641:Phenotype; D012559:Schizophrenia / Q000201:enzymology* / Q000235:genetics*
D005819:Genetic Markers; D008995:Monoamine Oxidase