Luteinizing hormone-releasing hormone (LHRH) and its analogs for contraception in women: a review.
In animals, LHRH agonists have multiple sites of action including the pituitary, the gonads, and the reproductive tract. In humans, the major antifertility action of this class of peptides is believed to be mediated via the pituitary. Studies in women have indicated that potent LHRH agonists can block ovulation when administered once daily. In the volunteers who have used these agents no serious side effects were observed, although some women experienced irregular bleeding or amenorrhea. It is anticipated that formal clinical trials could be conducted in the near future to determine the efficacy of continuous LHRH agonist administration. Early attempts to use an LHRH agonist to produce luteal insufficiency, luteolysis, or interruption of pregnancy have either been unsuccessful or the results are still too preliminary to ascertain whether these approaches warrant further trials. LHRH antagonists are believed to act by inhibiting the action of LHRH on the pituitary. Although some of these peptides are known to be active in women, very large doses have been required. Recently several investigators have produced LHRH antagonists with increased potency. In the near future, it should be possible to determine whether these peptides should be considered as potential contraceptives in men or in women.
D000028:Abortion, Induced; D000818:Animals; D002064:Buserelin / Q000494:pharmacology; D002986:Clinical Trials as Topic; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D003338:Corpus Luteum / Q000187:drug effects; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006066:Gonads / Q000187:drug effects; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D051379:Mice; D010060:Ovulation / Q000187:drug effects; D010215:Papio; D010903:Pituitary Gland, Anterior / Q000187:drug effects; D051381:Rats
D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D007987:Gonadotropin-Releasing Hormone; D002064:Buserelin