[Fibroblast cooperation in the graft of tumor cells in nude mice].
The occurrence and growth of xenogenic tumors in athymic Mice depend on å number of factors: the level of the immune response, the number of the injected tumor cells and the microenvironment of the tumor cells. We have demonstrated that the addition of cultivated fibroblasts to murine sarcoma cells was necessary for tumors to take. The addition of irradiated fibroblasts or of a medium conditioned by fibroblasts had the same effect. We therefore hypothesize an interaction between the fibroblasts which produce factors necessary for tumor cells and murine sarcoma cells which then initiate a tumor in the host. In vivo, tumor cells could induce host fibroblasts to produce growth factor(s) which in turn would help to initiate and maintain tumor growth.
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000502:physiology / Q000528:radiation effects; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D012208:Rhabdomyosarcoma / Q000276:immunology / Q000503:physiopathology*; D014183:Transplantation, Heterologous
Coopération des fibroblastes dans la greffe de cellules tumorales chez la Souris nude.