Serum lipoprotein lipid and apoprotein (B and A-I) responses to saturated fat-rich diet in cynomolgus monkeys: effects of carbohydrate type and cholesterol.
The effects of carbohydrate type and cholesterol in a high saturated fat diet (40% cal) on serum lipoprotein lipid and apoprotein responses were studied in 12 male cynomolgus monkeys (Macaca fascicularis). For 6 wk each monkey was fed one of four semipurified diets that provided by calorie 49% as starch or sucrose without and with 1 mg/kcal cholesterol. Starch and sucrose diets without added cholesterol resulted in similar levels of serum total cholesterol and apoB; whereas starch produced significantly higher values for these variables than sucrose when cholesterol was added to these diets. Starch diet, irrespective of dietary cholesterol, yielded significantly lower apoA-I levels than sucrose diet. Carbohydrate type did not affect serum triglyceride levels. Cholesterol-enriched starch diet resulted in relatively higher intermediate- and low-density lipoproteins and lower high-density lipoproteins in comparison to similar sucrose diet. Thus, the magnitude of responses of serum lipoproteins can be affected by the type of carbohydrate.
D000818:Animals; D016632:Apolipoprotein A-I; D001053:Apolipoproteins / Q000097:blood*; D001055:Apolipoproteins B; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004041:Dietary Fats / Q000494:pharmacology*; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008252:Macaca fascicularis; D008297:Male; D013213:Starch / Q000494:pharmacology; D013395:Sucrose / Q000494:pharmacology; D013997:Time Factors
D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D001055:Apolipoproteins B; D002791:Cholesterol, Dietary; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D013395:Sucrose; D013213:Starch