title: Activation of monocrotaline, fulvine and their derivatives to toxic pyrroles by some thiols.
abstract: Arylthiols - in contrast to n-alkylthiols, cysteine and reduced glutathione--dehydrogenated monocrotaline, fulvine, their N-oxides and retronecine to activated pyrrole derivatives. All thiols used failed to dehydrogenate N-methyl derivatives of monocrotaline and fulvine.
mesh_terms: D001711:Biotransformation; D055598:Chemical Phenomena; D002621:Chemistry; D016686:Monocrotaline; D011758:Pyrroles / Q000378:metabolism* / Q000633:toxicity; D011763:Pyrrolizidine Alkaloids / Q000378:metabolism*; D013438:Sulfhydryl Compounds / Q000378:metabolism*
chemical_list: D011758:Pyrroles; D011763:Pyrrolizidine Alkaloids; D013438:Sulfhydryl Compounds; D016686:Monocrotaline; C041169:fulvine