Serology and genetics of an MNSs-associated antigen Dantu.
Dantu, a previously undescribed low-incidence red cell antigen, is inherited as a Mendelian dominant character. The Dantu antigen is associated with very weak s antigen, protease resistant N antigen and either very weak or no U antigen. Two of the propositi had previously been shown to have an unusual hybrid MNSs sialoglycoprotein, and it is probably this which carries these unusual N, s and U antigens as well as the Dantu antigen. A study of the family of one propositus suggests, by conventional genetics, that Dantu is not controlled by the MNSs locus; a possible explanation is given. Several examples of anti-Dantu are known, one was found to cause a positive direct antiglobulin reaction on neonatal red cells.
D000017:ABO Blood-Group System; D000911:Antibodies, Monoclonal / Q000276:immunology; D002918:Chymotrypsin / Q000494:pharmacology; D003298:Coombs Test; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006801:Humans; D008951:MNSs Blood-Group System / Q000235:genetics; D008297:Male; D010206:Papain / Q000494:pharmacology; D010375:Pedigree; D011402:Pronase / Q000494:pharmacology; D012204:Rh-Hr Blood-Group System; D012795:Sialoglycoproteins / Q000235:genetics; D014357:Trypsin / Q000494:pharmacology
D000017:ABO Blood-Group System; D000911:Antibodies, Monoclonal; D008951:MNSs Blood-Group System; D012204:Rh-Hr Blood-Group System; D012795:Sialoglycoproteins; D002918:Chymotrypsin; D014357:Trypsin; D010206:Papain; D011402:Pronase