title: Impromidine (SK & F 92676) acts as a partial agonist on the isolated whole stomach of the rat.
abstract: The present secretory studies on the isolated stomach of the rat provide evidence that impromidine acts as a partial agonist at the histamine H2-receptors. It was found to be 100 times more potent than histamine but with a maximal response only 50% that obtained with histamine.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005750:Gastric Juice / Q000378:metabolism*; D006146:Guanidines / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D017446:Impromidine; D066298:In Vitro Techniques; D051381:Rats; D011968:Receptors, Histamine / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*
chemical_list: D006146:Guanidines; D007093:Imidazoles; D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D006632:Histamine; D017446:Impromidine