title: Gonorrhoea caused by a mixture of penicillinase-positive and -negative gonococci: a case report.
abstract: A 23-year-old unmarried man was infected with gonorrhoea from a prostitute in Fukuoka City and was treated with ampicillin which resulted in failure. By a rapid iodometric test it was found that the isolates before the treatment were penicillinase-negative. After the ampicillin treatment, however, the isolates turned to penicillinase-positive but were, in fact, a mixture of penicillinase-positive and penicillinase-negative gonococcal strains. Treatment by spectinomycin and doxycycline resulted in failure but the gonorrhoea was cured by ribostamycin.
mesh_terms: D000328:Adult; D004352:Drug Resistance, Microbial; D006069:Gonorrhea / Q000188:drug therapy / Q000382:microbiology*; D006801:Humans; D008297:Male; D009344:Neisseria gonorrhoeae / Q000145:classification / Q000201:enzymology* / Q000302:isolation & purification; D010405:Penicillinase / Q000096:biosynthesis*; D012271:Ribostamycin / Q000627:therapeutic use
chemical_list: D012271:Ribostamycin; D010405:Penicillinase