title: Initial expression of neurofilaments and vimentin in the central and peripheral nervous system of the mouse embryo in vivo.
abstract: The appearance of neurofilaments (NFs) and vimentin (Vim) in the nervous system of the mouse embryo was documented using immunohistochemical techniques. The three NF protein subunits appear early and simultaneously in central and peripheral neurons at 9 to 10 days of gestation. The onset of NF expression is concomitant with axon elongation and correlates extremely well with neurofibrillar differentiation and, in the case of autonomic ganglia, with the expression of adrenergic neurotransmitter properties. In the central and peripheral nervous system, NF expression is preceded by that of Vim, and both types of intermediate filaments coexist within the same cell for a short period of time.
mesh_terms: D000818:Animals; D000906:Antibodies; D002490:Central Nervous System / Q000196:embryology*; D003599:Cytoskeleton / Q000648:ultrastructure*; D005260:Female; D005455:Fluorescent Antibody Technique; D005865:Gestational Age; D007381:Intermediate Filament Proteins / Q000032:analysis*; D046911:Macromolecular Substances; D051379:Mice; D008970:Molecular Weight; D016900:Neurofilament Proteins; D010525:Peripheral Nerves / Q000196:embryology*; D011247:Pregnancy; D014746:Vimentin
chemical_list: D000906:Antibodies; D007381:Intermediate Filament Proteins; D046911:Macromolecular Substances; D016900:Neurofilament Proteins; D014746:Vimentin