title: [Long-term therapy of angina pectoris. Evaluation of the effectiveness and tolerance of oxyfedrine in ambulatory patients].
abstract: In an open multicentre trial, the clinical efficacy and tolerance of Oxyfedrine, (Ildamen forte) was evaluated in 123 patients with angina pectoris. After three months of treatment the frequency of anginal attacks and nitroglycerin consumption were markedly reduced in 80 percent, after 12 months in 88% of patients; 37 percent were totally angina-free and 50% were without need for sublingual nitroglycerin. Side-effects were reported by 23.6% of patients during the first months of treatment with a total of eight symptoms being reported in 40 instances; after one year, the incidence of side-effects was substantially reduced to 8 instances in 6 percent of patients. Laboratory investigation were not significantly affected: in 11 patients minor deviations from the reference range were noted without clinical relevance. Dropouts due do drug intolerance were not observed.
mesh_terms: D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D010099:Oxyfedrine / Q000009:adverse effects / Q000627:therapeutic use*; D011427:Propiophenones / Q000627:therapeutic use*
chemical_list: D011427:Propiophenones; D010099:Oxyfedrine
vernacular_title: Langzeittherapie der Angina pectoris. Beurteilung der Wirksamkeit und Verträglichkeit von Oxyfedrin bei ambulanten Patienten.