title: C1 inhibitor functional activities in hereditary angioedema plasma of patients under therapy with attenuated androgens.
abstract: The effects of therapy with danazol or stanozolol on complement component C4 and on C1 inhibitor concentrations and functions in 6 patients suffering from the common form of hereditary angioedema are described. Whereas the mean C4 concentration was found within the normal range, the therapy with attenuated androgens resulted in a subnormal mean of C1 inhibitor concentration, but an almost normal mean of functional activity.
mesh_terms: D000799:Angioedema / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D003181:Complement C4 / Q000032:analysis; D003613:Danazol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D008297:Male; D009391:Nephelometry and Turbidimetry; D011245:Pregnadienes / Q000627:therapeutic use*; D013197:Stanozolol / Q000627:therapeutic use*
chemical_list: D003181:Complement C4; D011245:Pregnadienes; D013197:Stanozolol; D003613:Danazol