Reiter's disease in northern India. A clinical and immunogenetic study.
Thirty-six patients fulfilling the criteria for Reiter's disease were studied (29 men and 7 women; 4:1). The mean age of onset was 23.8 years; in 75% of patients the onset was in the second and third decades. Clinical manifestations included low back pain and stiffness (69%), non specific urethritis (53%), heel pain (44%), radiographic sacroiliitis (42%), conjunctivitis (39%), dysentery and diarrhoea (33%), mucosal ulcerations (17%) kidney disease (14%), anterior uveitis (19%), and keratoderma blennorrhagicum (8%). Peripheral arthritis was mono or oligoarthritis in 58% of patients, mainly affecting the large joints of lower extremities, and it was often asymmetric (mean degree of asymmetry = 0.37). HLA-B27 antigen was detected in 83% of 36 patients compared with 5.9% of 118 controls (relative risk 79, corrected Fisher's P = 7.719E-18).
D000293:Adolescent; D000328:Adult; D001168:Arthritis / Q000175:diagnosis; D016918:Arthritis, Reactive / Q000175:diagnosis* / Q000276:immunology; D002648:Child; D003231:Conjunctivitis / Q000175:diagnosis; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000175:diagnosis; D004403:Dysentery / Q000175:diagnosis; D005260:Female; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000302:isolation & purification; D015796:HLA-B27 Antigen; D006365:Heel; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000175:diagnosis; D012217:Rheumatoid Factor / Q000302:isolation & purification; D012446:Sacroiliac Joint; D014526:Urethritis / Q000175:diagnosis; D014605:Uveitis / Q000175:diagnosis
D006680:HLA Antigens; D015796:HLA-B27 Antigen; D012217:Rheumatoid Factor