Role of ornithine decarboxylase in cardiac growth and hypertrophy.
Inhibition of cardiac ornithine decarboxylase (ODC) by alpha-difluoromethylornithine (DFMO) did not prevent normal cardiac growth in mature rats but attenuated isoproterenol-induced hypertrophy. Hypertrophy caused by triiodothyronine was not prevented by DFMO. There appear to be both ODC-dependent and ODC-independent processes contributing to the subcellular mechanisms associated with growth, which must be considered in the potential laboratory and clinical use of DFMO.
D000818:Animals; D002262:Carboxy-Lyases / Q000378:metabolism*; D006332:Cardiomegaly / Q000139:chemically induced / Q000378:metabolism* / Q000517:prevention & control; D000518:Eflornithine; D006321:Heart / Q000254:growth & development*; D007545:Isoproterenol / Q000037:antagonists & inhibitors; D008297:Male; D009206:Myocardium / Q000201:enzymology; D009952:Ornithine / Q000031:analogs & derivatives / Q000494:pharmacology; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D065108:Ornithine Decarboxylase Inhibitors; D051381:Rats; D014284:Triiodothyronine / Q000037:antagonists & inhibitors
D065108:Ornithine Decarboxylase Inhibitors; D014284:Triiodothyronine; D009952:Ornithine; D002262:Carboxy-Lyases; D009955:Ornithine Decarboxylase; D007545:Isoproterenol; D000518:Eflornithine