title: IgA deficiency during treatment of infantile hypothyroidism with thyroxine.
abstract: Serum IgA concentrations in five children with infantile hypothyroidism fell soon after the start of treatment with thyroxine. In one child the IgA concentration fell appreciably (to less than 0.01 g/1) and remained reduced; in the four others it returned to normal. IgM and IgG concentrations were roughly normal throughout. The deficiency in IgA concentrations may have been due to stimulation by thyroxine treatment of a T cell suppressor system that, in the original hypothyroid state, was less than normally active.
mesh_terms: D002675:Child, Preschool; D004406:Dysgammaglobulinemia / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy*; D017098:IgA Deficiency; D007223:Infant; D013974:Thyroxine / Q000009:adverse effects* / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D013974:Thyroxine