Histamine-evoked nasal secretion in the dog.
Nasal secretory activity was measured in seven dogs in response to topical stimulation by histamine and methacholine. The methacholine response was blocked by atropine but not by chlorpheniramine. The histamine response was blocked by chlorpheniramine but not by atropine. These results suggest that there are two independent mechanisms of nasal secretion in the dog.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002744:Chlorpheniramine / Q000494:pharmacology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000494:pharmacology* / Q000502:physiology; D016210:Methacholine Chloride; D008688:Methacholine Compounds / Q000494:pharmacology; D009297:Nasal Mucosa / Q000187:drug effects / Q000378:metabolism*; D009299:Nasal Provocation Tests; D013268:Stimulation, Chemical
D008688:Methacholine Compounds; D016210:Methacholine Chloride; D002744:Chlorpheniramine; D001285:Atropine; D006632:Histamine