title: Surface changes in rat gastric mucosa induced by sodium fluoride: a scanning electron microscopic study.
abstract: This paper describes the ultrastructural, topographical changes seen in rat gastric mucosa following application of 0.1 N HCl or 1, 10 or 50 mM NaF in 0.1 N HCl to the stomach. No morphological differences were noticed between the 0.1 N HCl (control) and 1 mM NaF in 0.1 N HCl specimens. Ten milliomolar NaF in 0.1 N HCl produced some desquamation of surface mucous epithelial cells while 50 mM NaF produced extensive damage to cells surrounding the gastric gland openings (foveolae) as well as interfoveolar cell loss.
mesh_terms: D000818:Animals; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D005260:Female; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure*; D006851:Hydrochloric Acid; D008855:Microscopy, Electron, Scanning; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D012969:Sodium Fluoride; D006851:Hydrochloric Acid