Treatment of hirsutism, acne and alopecia with cyproterone acetate.
Cyproterone acetate, combined with ethinyl estradiol, was administered to 60 women (mean age: 25 years) suffering from hirsutism, acne and alopecia for 3--39 months. The rate of success was 94% for acne, 85% for hirsutism and 55% for alopecia. These results are comparable to those already reported. No correlation was found between the degree of the disease or plasma levels of testosterone, androstenedione, respectively urinary 17-cetosteroids, and the effectiveness of the treatment. Side effects were rare and identical in frequency and nature to those encountered during treatment with estrogen-containing contraceptives.
D015068:17-Ketosteroids / Q000652:urine; D000152:Acne Vulgaris / Q000188:drug therapy* / Q000378:metabolism; D000328:Adult; D000505:Alopecia / Q000188:drug therapy* / Q000378:metabolism; D000735:Androstenedione / Q000097:blood; D003534:Cyproterone / Q000627:therapeutic use*; D005260:Female; D006628:Hirsutism / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D013739:Testosterone / Q000097:blood
D015068:17-Ketosteroids; D013739:Testosterone; D000735:Androstenedione; D003534:Cyproterone