[Demonstration of the correlation of the degree of synthesis and 4-aminobutyric acid levels in the central nervous system; effect of repeated convulsive seizures].
GABA turnover rates have been determined in 15 brain areas in five inbred strains of Mice or sublines (DBA/2J, C57/6J, Swiss Rb1, Swiss Rb2, Swiss Rb3). GABA turnover rates and levels are correlated (2 P less than 0.05). After repeated seizures (twice a day for 15 days), induced by an acoustic stimulus in Swiss Rb1 Mice selected for audiogenic seizures, this correlation is no longer observed.
D000161:Acoustic Stimulation; D000818:Animals; D001921:Brain / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D012640:Seizures / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid
Mise en évidence d'une corrélation entre le taux de synthèse et la teneur en acide 4-aminobutyrique dans le système nerveux central; effet des crises convulsives répétées.