Effect of bilirubin and its photodegradation products on the respiration of mitochondria isolated from rat liver.
In 0.05--0.1 mmol.l-1 concentration, bilirubin inhibits ADP-activated respiration of isolated liver mitochondria; it has no effect on respiration in the absence of ADP. Bilirubin-induced inhibition of respiration is not abolished by serum albumin, but bilirubin bound to serum albumin and the photodegradation products of bilirubin have no inhibitory effect.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001663:Bilirubin / Q000031:analogs & derivatives / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D010782:Photolysis; D051381:Rats; D012709:Serum Albumin / Q000494:pharmacology; D013386:Succinates / Q000378:metabolism
D012709:Serum Albumin; D013386:Succinates; D000244:Adenosine Diphosphate; D001663:Bilirubin