Frequency of apolipoprotein A-I mutants in the German population.
A randomly chosen population in the area of Westphalia (West Germany) was screened for apolipoprotein A-I mutants. About 5000 individuals were investigated and compared with a group of 1300 patients who had undergone coronary angiography. Four electrophoretically different apolipoprotein A-I-mutants (named Münster-1 to 4) were discovered. Five non-related probands were observed in the group of the unselected patients and three non-related probands in the group of coronary angiography patients. In most cases the familial nature of the abnormality was confirmed by pedigree analysis.
D000328:Adult; D016632:Apolipoprotein A-I; D001054:Apolipoproteins A / Q000097:blood / Q000235:genetics*; D003327:Coronary Disease / Q000097:blood / Q000235:genetics; D003488:Cyanogen Bromide; D005260:Female; D005860:Germany, West; D006801:Humans; D006868:Hydrolysis; D007123:Immunoelectrophoresis, Two-Dimensional; D007525:Isoelectric Focusing; D008297:Male; D008875:Middle Aged; D009154:Mutation
D016632:Apolipoprotein A-I; D001054:Apolipoproteins A; D003488:Cyanogen Bromide