title: Activation of coagulation factors on the surface of platelets.
abstract: Platelet physiology and coagulation biochemistry have traditionally been studied and conceptualized as separate and distinct entities. This brief summary of platelet-coagulant protein interactions presents an alternative viewpoint which emphasizes the effects of platelets in coagulation and the effects of coagulation proteins on platelet physiology. These interrelationships are so intimate and important that any consideration of the hemostasis mechanism that fails to take them into account is meaningless.
mesh_terms: D001777:Blood Coagulation; D001792:Blood Platelets / Q000032:analysis / Q000502:physiology*; D004789:Enzyme Activation; D005165:Factor V / Q000032:analysis; D005169:Factor VIII / Q000032:analysis; D005170:Factor X / Q000502:physiology; D005174:Factor XII / Q000502:physiology; D005176:Factor XIII / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007704:Kininogens / Q000032:analysis; D011516:Prothrombin / Q000502:physiology
chemical_list: D007704:Kininogens; D005165:Factor V; D011516:Prothrombin; D005169:Factor VIII; D005170:Factor X; D005174:Factor XII; D005340:Fibrinogen; D005176:Factor XIII