Human and murine natural killer cell activity may require lipoxygenation of arachidonic acid.
Natural killing (spontaneous cell-mediated cytotoxicity) by either human blood cells or mouse spleen cells is reversibly inhibited by nordihydroquaiaretic acid or BW755C, agents that antagonize the lipoxygenation of arachidonic acid. Cultured mouse natural killer cells are similarly inhibited. These studies suggest that natural killing may be dependent on the lipoxygenation of arachidonic acid.
D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects; D000975:Antioxidants / Q000494:pharmacology; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D002396:Catechols / Q000494:pharmacology; D002460:Cell Line; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D015470:Leukemia, Myeloid, Acute / Q000276:immunology; D009637:Masoprocol; D011720:Pyrazoles / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D000975:Antioxidants; D001095:Arachidonic Acids; D002396:Catechols; D011720:Pyrazoles; D016718:Arachidonic Acid; D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D009637:Masoprocol; D007213:Indomethacin