Effect of different total parenteral nutrition fuel mixes on the body composition of infant miniature pigs.
At 10 d of age miniature pigs were randomized to receive either of two total parenteral nutrition fuel mixes; oral feedings were discontinued. Both groups received 170 kcal X kg-1 X d-1 and 11 g X kg-1 X d-1 of synthetic amino acids. Nonprotein energy was supplied as glucose in group A, whereas in group B, it was divided equally between glucose and fat. Blood samples were drawn on the second and eighth postoperative days for hematologic, biochemical, and hormonal measurements. On the ninth postoperative day, total body water was determined and the animals were killed for carcass analysis. The animals tolerated the intravenous nutrition without ill effects as indicated by both clinical and biochemical parameters. Group A had significantly elevated levels of insulin and a higher insulin/glucagon ratio than group B. Cortisol levels did not differ significantly between groups. Total body fat, nitrogen, ash, K, Na, Cl, Ca, and P were similar between groups. TBW was significantly greater in group A compared with group B. Extracellular space calculated from body Cl and plasma Cl was similar between groups.
D000273:Adipose Tissue / Q000033:anatomy & histology; D000596:Amino Acids / Q000008:administration & dosage; D000818:Animals; D001823:Body Composition; D001834:Body Water; D004573:Electrolytes / Q000378:metabolism; D005217:Fat Emulsions, Intravenous; D005947:Glucose / Q000008:administration & dosage; D006728:Hormones / Q000097:blood; D010288:Parenteral Nutrition; D010289:Parenteral Nutrition, Total; D011897:Random Allocation; D013552:Swine; D013556:Swine, Miniature
D000596:Amino Acids; D004573:Electrolytes; D005217:Fat Emulsions, Intravenous; D006728:Hormones; D005947:Glucose