Effect of ascorbic acid on desferrioxamine-induced urinary iron excretion in idiopathic hemochromatosis.
The effect on urinary iron excretion (UIE) of vitamin C administered orally 2 h after the start of an 8-hour desferrioxamine (DF) i.v. infusion was studied in 12 patients with untreated idiopathic hemochromatosis (IH). Mean +/- SEM basal UIE of 324.6 +/- 84.6 micrograms/24 h increased after a 1-gram i.v. DF infusion to 8,778.5 +/- 1,191.4 micrograms/24 h; when vitamin C 1 or 2 g were added to DF i.v. infusion, there were further increases to 11,241.5 +/- 1,486.1 (p less than 0.01) and 13,531.2 +/- 1,697.2 micrograms/24 h (p less than 0.05 versus the last value), respectively. Basal UIE did not significantly increase after oral vitamin C administration alone. No side effects were observed.
D000328:Adult; D001205:Ascorbic Acid / Q000494:pharmacology*; D003676:Deferoxamine / Q000627:therapeutic use*; D005260:Female; D006432:Hemochromatosis / Q000188:drug therapy / Q000652:urine*; D006801:Humans; D007501:Iron / Q000652:urine*; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D007501:Iron; D003676:Deferoxamine; D001205:Ascorbic Acid