The use of iron and gadolinium chelates as NMR contrast agents: animal and human studies.
Rapid development of paramagnetic NMR contrast agents has occurred over the past 3 years. Useful agents include chelates of iron and gadolinium. Gadolinium-DTPA was used safely in 23 human subjects with brain tumors, hepatic tumors and cysts, and a variety of abdominal and pelvic tumors. Various patterns of contrast-enhancement were noted. These agents can radically alter NMR image contrast. Optimum doses, pulse sequences and timing of imaging remain to be determined.
D000008:Abdominal Neoplasms / Q000175:diagnosis; D000818:Animals; D001932:Brain Neoplasms / Q000175:diagnosis; D003110:Colonic Neoplasms / Q000175:diagnosis; D003287:Contrast Media; D004492:Edetic Acid; D005290:Ferric Compounds; D006801:Humans; D007501:Iron; D008113:Liver Neoplasms / Q000175:diagnosis / Q000556:secondary; D009682:Magnetic Resonance Spectroscopy; D009369:Neoplasms / Q000175:diagnosis*; D010190:Pancreatic Neoplasms / Q000175:diagnosis; D010386:Pelvic Neoplasms / Q000175:diagnosis; D004369:Pentetic Acid; D011817:Rabbits; D013329:Structure-Activity Relationship
D003287:Contrast Media; D005290:Ferric Compounds; D004369:Pentetic Acid; D004492:Edetic Acid; D007501:Iron; C019179:Fe(III)-EDTA