Cryptic I antigen activity and Mycoplasma pneumoniae-receptor activity associated with sialoglycoprotein GP-2 of bovine erythrocyte membranes.
The 250-kDa sialoglycoprotein of bovine erythrocyte membranes, GP-2, has been found to be an exceptionally rich source of branched sialo-oligosaccharides of poly-N-acetyllactosamine (I antigen) type with receptor activity for the human pathogen Mycoplasma pneumoniae. Desialylated GP-2 is the most potent I-active substance thus far tested. Since this glycoprotein is hydrophobic and can be readily re-incorporated into cell membranes, it should be useful in future studies of the mechanism of production of autoantibodies to the I antigen which commonly arise following human infection with M. pneumoniae.
D000818:Animals; D000936:Antigen-Antibody Complex; D000942:Antigens, Bacterial / Q000032:analysis*; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D002417:Cattle; D004910:Erythrocyte Membrane / Q000276:immunology*; D008565:Membrane Proteins / Q000276:immunology* / Q000302:isolation & purification; D008970:Molecular Weight; D009177:Mycoplasma pneumoniae / Q000276:immunology*; D011946:Receptors, Antigen / Q000032:analysis*; D012795:Sialoglycoproteins / Q000276:immunology* / Q000302:isolation & purification
D000936:Antigen-Antibody Complex; D000942:Antigens, Bacterial; D008565:Membrane Proteins; D011946:Receptors, Antigen; D012795:Sialoglycoproteins