title: Lamellar bodies are the intracellular site of membrane turnover in insect fat body.
abstract: Analysis of the time course of highly cationic ferritin uptake by fat body cells has shown that the tracer bound to the plasma membrane and was pinocytosed by coated vesicles. The first sites of intracellular accumulation were multivesicular bodies which became filled with ferritin between 30-60 min after cells were exposed to the tracer. At no time during the experiments were any parts of the Golgi complex labeled by the tracer. By 60 min, the ferritin was increasingly found in lamellar bodies. The different types of 'light' and 'dark' multivesicular bodies suggest that lamellar bodies form from multivesicular bodies as they fill with tracer. The occurrence of lamellar bodies in many different cell types suggests an important role in membrane dynamics.
mesh_terms: D000273:Adipose Tissue / Q000648:ultrastructure*; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism*; D003034:Coated Pits, Cell-Membrane / Q000378:metabolism; D005216:Fat Body / Q000378:metabolism / Q000648:ultrastructure*; D005293:Ferritins / Q000378:metabolism*; D007915:Lepidoptera / Q000648:ultrastructure; D009940:Organoids / Q000378:metabolism*; D010873:Pinocytosis; D013997:Time Factors
chemical_list: D005293:Ferritins