title: Toxin receptors and their pathogenetic significance.
abstract: The pathogenetic significance of toxin receptor interaction in disease is examplified by infectious diarrhoea. The world-wide problem of infectious diarrhoea is presented with regard to epidemiology, etiology, and pathophysiology. Enterotoxigenic diarrhoea is examined in the light of recent knowledge on toxin receptor interaction, which has greatly contributed to new vaccine as well as drug development in this disease condition.
mesh_terms: D000262:Adenylyl Cyclases / Q000096:biosynthesis; D000818:Animals; D002746:Chlorpromazine / Q000627:therapeutic use; D002771:Cholera / Q000628:therapy; D002772:Cholera Toxin / Q000096:biosynthesis / Q000378:metabolism; D022121:Cholera Vaccines / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003967:Diarrhea / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D004768:Enterotoxins / Q000096:biosynthesis; D004789:Enzyme Activation; D004926:Escherichia coli / Q000378:metabolism; D005440:Fluid Therapy; D005677:G(M1) Ganglioside / Q000378:metabolism; D006162:Guanylate Cyclase; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007419:Intestinal Secretions / Q000378:metabolism; D011817:Rabbits; D011956:Receptors, Cell Surface; D000074261:Receptors, Enterotoxin; D050705:Receptors, Guanylate Cyclase-Coupled; D011971:Receptors, Immunologic / Q000378:metabolism; D018000:Receptors, Peptide; D014734:Vibrio cholerae / Q000378:metabolism / Q000472:pathogenicity
chemical_list: D022121:Cholera Vaccines; D004768:Enterotoxins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; D018000:Receptors, Peptide; C023552:choleragen receptor; D005677:G(M1) Ganglioside; D002772:Cholera Toxin; D000262:Adenylyl Cyclases; D006162:Guanylate Cyclase; D000074261:Receptors, Enterotoxin; D050705:Receptors, Guanylate Cyclase-Coupled; D002746:Chlorpromazine