[Hypertriglyceridemia in intravenous hyperalimentation with glucose. Observations on patients treated with cyclosporin-A following bone marrow transplantation].
The authors report marked hypertriglyceridaemia with peak values of up to 14 mmol/l in patients who have undergone bone marrow transplantation (BMT) and who are receiving 925 g/d glucose and 70 g/d crystalline amino acids for parenteral nutrition. Larger doses of insulin lead to only slightly better control of mean blood glucose level and to a clearly less marked increase in triglycerides (TG) in a series of patients otherwise treated identically. Only a slight increase in serum TG was seen in BMT patients receiving 325 g glucose per day. There was no increase in serum TG to values above normal in a small group of surgical patients receiving 700-900 g glucose/d and high doses of insulin. Peripheral insulin resistance is presumed to be the pathogenetic factor in this hypertriglyceridaemia, mia, which can be avoided by higher doses of insulin or decreased glucose load.
D000328:Adult; D016026:Bone Marrow Transplantation; D003524:Cyclosporins / Q000627:therapeutic use; D005260:Female; D005947:Glucose / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood / Q000209:etiology* / Q000517:prevention & control; D007328:Insulin / Q000008:administration & dosage; D008297:Male; D010288:Parenteral Nutrition / Q000009:adverse effects*; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D014280:Triglycerides / Q000097:blood
D003524:Cyclosporins; D007328:Insulin; D014280:Triglycerides; D005947:Glucose
Hypertriglyceridämie bei intravenöser Hyperalimentation mit Glucose. Beobachtungen bei cyclosporin-A-behandelten Patienten nach Knochenmarktransplantation.