Studies on the promoting and complete carcinogenic activities of some oxidizing chemicals in skin carcinogenesis.
Six oxidizing chemicals were tested for promoting and complete carcinogenic activities in skin carcinogenesis using female Sencar mice. In the promotion tests, the chemicals were applied twice a week for 51 weeks after initiation with dimethylbenzanthracene (DMBA). In the tests for complete carcinogenic activities, the chemicals alone were applied for 51 weeks. Benzoyl peroxide was found to be a potent promoter as reported previously. Moreover, possible complete carcinogenic action of this chemical was found in this study. Potential promoting effect was suspected in sodium chlorite. Potassium bromate, ammonium persulphate, hydrogen peroxide and sodium hypochlorite were inactive either as a promoter or a complete carcinogen.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001585:Benzoyl Peroxide / Q000633:toxicity; D001959:Bromates / Q000633:toxicity; D002712:Chlorides / Q000633:toxicity; D005260:Female; D006861:Hydrogen Peroxide / Q000633:toxicity; D051379:Mice; D010084:Oxidation-Reduction; D012878:Skin Neoplasms / Q000139:chemically induced*; D012973:Sodium Hypochlorite / Q000633:toxicity; D013755:Tetradecanoylphorbol Acetate
D001959:Bromates; D002712:Chlorides; C019536:potassium bromate; D015127:9,10-Dimethyl-1,2-benzanthracene; D006861:Hydrogen Peroxide; D012973:Sodium Hypochlorite; D013755:Tetradecanoylphorbol Acetate; D001585:Benzoyl Peroxide; C001599:chlorite