Immunoglobulin gene rearrangement in acute myelogenous leukemia.
Twenty-one cases of newly diagnosed nonlymphocytic leukemia were subjected to analysis of immunoglobulin gene organization. Although immunoglobulin gene organization is an essential property of B-lineage cells, immunoglobulin gene rearrangement has also been observed in mouse T-cells and occasionally in cultured human T-cell leukemic cells. Here we report the first case of acute myelogenous leukemia in which mu-chain gene rearrangement is demonstrated. This finding provides a further step in our understanding of both normal and abnormal hematopoietic cell differentiation and the heterogeneity of nonlymphocytic leukemia.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D001853:Bone Marrow / Q000473:pathology; D002648:Child; D005260:Female; D005796:Genes; D006801:Humans; D007148:Immunoglobulin mu-Chains / Q000235:genetics; D007136:Immunoglobulins / Q000235:genetics*; D007938:Leukemia / Q000235:genetics / Q000276:immunology*; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000276:immunology*
D007148:Immunoglobulin mu-Chains; D007136:Immunoglobulins