title: Simultaneous spectrophotometric determination of nifuroxime and furazolidone in pharmaceutical preparations.
abstract: Two spectrophotometric methods have been developed for the simultaneous determination of nifuroxime and furazolidone in their pharmaceutical preparations. No preliminary separation step is required in either method. The first, a modified Vierordt method, gives accurate and reproducible results for both drugs. Mean percent recoveries for nifuroxime and furazolidone were 99.50 +/- 1.59 and 100.20 +/- 1.16 (P = 0.05), respectively. This method also gives accurate and reproducible results for the determination of nifuroxime and furazolidone in their pharmaceutical preparations: Tricofuran vaginal suppositories and powder. The second method, which involves the use of the first-derivative curves, gives unreliable results; the reasons for these are discussed.
mesh_terms: D004338:Drug Combinations / Q000032:analysis; D005664:Furazolidone / Q000032:analysis*; D009581:Nitrofurans / Q000032:analysis*; D013053:Spectrophotometry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D004338:Drug Combinations; D009581:Nitrofurans; D005664:Furazolidone