Two unlinked genetic loci interact to control the human immune response to type III group B streptococcal antigen.
Serum samples were collected from 30 healthy adult Caucasian volunteers before and after immunization with native type III polysaccharide of group B streptococcus. Serum antibody to this polysaccharide was measured and sera were typed for several Gm and Km(1) allotypes. A significant interactive effect of Gm(23) and Km(1) was found on immune responsiveness to native type III group B streptococcus polysaccharide antigen.
D000942:Antigens, Bacterial / Q000276:immunology*; D005802:Genes, MHC Class II; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics; D007142:Immunoglobulin gamma-Chains / Q000235:genetics; D007145:Immunoglobulin kappa-Chains / Q000235:genetics; D011135:Polysaccharides, Bacterial / Q000235:genetics; D013292:Streptococcus agalactiae / Q000276:immunology*
D000942:Antigens, Bacterial; D007126:Immunoglobulin Allotypes; D007142:Immunoglobulin gamma-Chains; D007145:Immunoglobulin kappa-Chains; D011135:Polysaccharides, Bacterial