title: Nature of the reversible white matter lesion in multiple sclerosis. Effects of acute inflammation on myelinated tissue studied in the rabbit eye.
abstract: Arthus reactions of different intensities were induced in the rabbit eye using measles vaccine as the immunogen. In the presence of a mild Arthus reaction in the vitreous, myelinated nerve fibre bundles on the retinal surface revealed extracellular oedema together with marked swelling and rupture of astrocyte processes, including those bearing a special relationship to nodes of Ranvier. These changes improved or disappeared over the course of six days. No demyelination occurred. The findings implicate an astrocytic lesion as a possible cause of reversible neurological deficit and conduction block associated with acute inflammation in central white matter.
mesh_terms: D000818:Animals; D001183:Arthus Reaction / Q000473:pathology; D001253:Astrocytes / Q000473:pathology; D001921:Brain / Q000473:pathology; D005123:Eye / Q000473:pathology*; D005260:Female; D007249:Inflammation / Q000473:pathology; D008297:Male; D008458:Measles Vaccine; D009103:Multiple Sclerosis / Q000473:pathology*; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D011817:Rabbits; D012160:Retina / Q000294:innervation
chemical_list: D008458:Measles Vaccine