title: Behavioral control of intractable idiopathic seizures: I. Self-regulation of end-tidal carbon dioxide.
abstract: Eleven women and seven men with moderate to severe chronic hyperventilation and idiopathic seizures refractory to therapeutic serum levels of anticonvulsant medication were given diaphragmatic respiration training with percent end-tidal CO2 biofeedback. The training had a rapid correcting effect on their respiration, making it comparable to that of 18 asymptomatic control subjects. Ten of the seizure-group subjects were in the study at least 7 months and following treatment, 8 showed EEG power spectrum "normalization", restoration of cardio-respiratory synchrony (RSA), and their seizure frequency and severity were significantly reduced.
mesh_terms: D000293:Adolescent; D000328:Adult; D001676:Biofeedback, Psychology; D002245:Carbon Dioxide / Q000502:physiology*; D002648:Child; D004562:Electrocardiography; D004569:Electroencephalography; D004827:Epilepsy / Q000628:therapy*; D004830:Epilepsy, Tonic-Clonic / Q000628:therapy; D005260:Female; D006801:Humans; D006985:Hyperventilation / Q000628:therapy; D008297:Male; D012119:Respiration
chemical_list: D002245:Carbon Dioxide