Effect of a diphosphonate on the osteoinductive activity of rat bone matrix.
Implants of demineralized allogeneic bone were investigated to determine the effects of ethane-1-hydroxy-1,1-diphosphonate (EHDP) on the osteoinductive effect of bone matrix. Implants of matrix prepared from bones of rats treated by EHDP (20 mg/kg/day) produced 40% less ash than implants of normal bone matrix. These results indicate that EHDP not only interferes with mineralization but also has a direct effect on protein metabolism of bone cells.
D000818:Animals; D001857:Bone Matrix / Q000637:transplantation; D001842:Bone and Bones / Q000032:analysis / Q000648:ultrastructure; D012968:Etidronic Acid / Q000494:pharmacology*; D008297:Male; D010012:Osteogenesis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D012968:Etidronic Acid