title: Immunoselection screening methods for detection of the free heavy chains.
abstract: Immunoselection screening methods were developed for the detection of the free heavy chain determinants of biological fluids. The optimal sensitivity range of the electrosyneresis and electroimmunoassay type methods lies between 400 ng and 2 micrograms/ml and between 3 micrograms and 1 mg/ml for immunoglobulins. The sensitive, relatively rapid and cheap variants of the procedure are suitable for the detection of "heavy chain diseases" and of heavy chain fragments.
mesh_terms: D006362:Heavy Chain Disease / Q000276:immunology* / Q000652:urine; D006801:Humans; D007106:Immune Sera; D007122:Immunoelectrophoresis / Q000379:methods*; D007143:Immunoglobulin Heavy Chains / Q000652:urine*; D007147:Immunoglobulin Light Chains / Q000276:immunology
chemical_list: D007106:Immune Sera; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains