Effect of combination chemotherapy on PGE-mediated immunoregulation in the peripheral blood mononuclear cells of solid tumor cancer patients.
The effect of cytotoxic chemotherapy on phytohemagglutinin (PHA)-induced lymphocyte DNA synthesis was monitored in the peripheral blood mononuclear cells (PBMC) of drug-treated solid tumor cancer patients. The results obtained were correlated with changes in indomethacin-sensitive immunoregulatory function, prostaglandin E (PGE) levels, and PBMC PGE sensitivity. Those patients who demonstrated "rebound-overshoot" recovery of PHA responsiveness following their drug treatment did so in association with a significant reduction in levels of indomethacin-sensitive immunoregulation. This was associated with a significant decline in PGE-levels in PBMC. This was not consistently associated with a reduction in the sensitivity of PBMC to suppression by PGE. These data show that immune function recovery in drug-treated cancer patients is dependent in part on the effects of chemotherapy on PGE synthesis by PBMC.
D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D002448:Cell Adhesion; D004359:Drug Therapy, Combination; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D009000:Monocytes / Q000276:immunology; D009369:Neoplasms / Q000188:drug therapy / Q000276:immunology*; D011458:Prostaglandins E / Q000494:pharmacology*
D001095:Arachidonic Acids; D011458:Prostaglandins E; D016718:Arachidonic Acid