title: Large hypothalamic and optic chiasm gliomas in infants: difficulties in distinction.
abstract: Hypothalamic and optic chiasm gliomas may be indistinguishable clinically, radiographically, and pathologically. Ten children with giant gliomas of the hypothalamus and optic pathway, all under age 2 years, had masses greater than 3 cm in diameter. Pathologically all proven cases (seven) were cytologically benign fibrillary astrocytomas. Previous authors have recognized the difficulty in distinguishing these lesions; in this series, using previously suggested criteria, masses of optic chiasm could not be differentiated from hypothalamic origins. Likewise, at surgery and autopsy, the origin of these large masses was indeterminate. These tumors were more aggressive, invasive, and less responsive to therapy than the relatively benign orbital and optic nerve gliomas of older children and adults.
mesh_terms: D001254:Astrocytoma / Q000000981:diagnostic imaging* / Q000473:pathology; D003390:Cranial Nerve Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D007031:Hypothalamus / Q000473:pathology; D007223:Infant; D008297:Male; D009897:Optic Chiasm / Q000000981:diagnostic imaging* / Q000473:pathology; D014057:Tomography, X-Ray Computed