Mammary tumor induction in analbuminemic rats by 7,12-dimethylbenz(a)anthracene.
Induction by 7,12-dimethylbenz(a)anthracene of mammary tumors was studied in analbuminemic rats, a mutant strain established from Sprague-Dawley rats which are characterized by the absence of serum albumin and hyperlipidemia. Twenty-three weeks after carcinogen administration, the incidence and average number of mammary tumors and the tumor weight per tumor-bearing rat were respectively 35.0%, 1.7 +/- 0.2 (S.E.) and 8.9 +/- 0.5 g in analbuminemic rats and 69.2%, 2.3 +/- 0.2 and 12.2 +/- 2.8 g in the controls. Associated with this lower mammary tumorigenic response, analbuminemic rats had significantly lower plasma prolactin levels than controls during proestrus at 7-8 weeks of age when carcinogen was given (176 +/- 62 vs 308 +/- 52 ng/ml).
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D004971:Estrus; D005260:Female; D006949:Hyperlipidemias / Q000150:complications; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D011247:Pregnancy; D011388:Prolactin / Q000097:blood; D051381:Rats; D011922:Rats, Mutant Strains; D012709:Serum Albumin / Q000172:deficiency*; D013997:Time Factors
D001551:Benz(a)Anthracenes; D012709:Serum Albumin; D015127:9,10-Dimethyl-1,2-benzanthracene; D011388:Prolactin