[Effect of naloxone and thyroliberin on respiration in acute hypoxia].
Experiments on 48 adult rats anesthetized with urethane were made to study the effects of naloxone and thyrotropin-releasing hormone on respiration after acute hemorrhage. The drugs were injected intravenously in doses 0.25-0.30 mg/kg. The changes found in the electromyogram of the diaphragm, blood pressure and ECG demonstrated naloxone and thyrotropin-releasing hormone to stimulate the respiratory center at different stages of respiratory disorders (dyspnea, apnea, gasping) induced by hemorrhage.
D000208:Acute Disease; D000818:Animals; D001794:Blood Pressure; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D004576:Electromyography; D006470:Hemorrhage / Q000503:physiopathology; D000860:Hypoxia / Q000188:drug therapy* / Q000503:physiopathology; D009270:Naloxone / Q000627:therapeutic use*; D051381:Rats; D012119:Respiration / Q000187:drug effects*; D013268:Stimulation, Chemical; D013973:Thyrotropin-Releasing Hormone / Q000627:therapeutic use*
D009270:Naloxone; D013973:Thyrotropin-Releasing Hormone
Vliianie naloksona i tiroliberina na dykhanie v usloviiakh ostroĭ gipoksii.