The inhibitory effect of flurofamide on ureaplasmas and their elimination from marmosets by its use.
Flurofamide, a potent inhibitor of urease, at concentrations of 0.0007 to 0.001 mg/l inhibited the multiplication of three ureaplasma strains of human genital origin (one tetracycline-resistant) and two and three strains of marmoset genital and oral origin, respectively. However, a more than 1000-fold greater concentration of the drug was required to kill the organisms. Flurofamide did not inhibit the growth of arginine-hydrolysing or glucose-fermenting mycoplasmas, indicating its specificity for ureaplasmas. When it was given orally in a dose of 25 mg twice on one day and 25 mg on one further day to marmosets infected naturally with ureaplasmas in their throats, the organisms disappeared rapidly. The animals remained ureaplasma-free for 42 to 106 days, at which time they were successfully infected experimentally.
D000818:Animals; D001549:Benzamides / Q000494:pharmacology* / Q000627:therapeutic use; D002143:Callitrichinae; D005260:Female; D008826:Microbial Sensitivity Tests; D009174:Mycoplasma / Q000187:drug effects; D009175:Mycoplasma Infections / Q000517:prevention & control; D010614:Pharynx / Q000382:microbiology; D014509:Ureaplasma / Q000187:drug effects*; D014510:Urease / Q000037:antagonists & inhibitors*
D001549:Benzamides; C032764:flurofamide; D014510:Urease