Stimulation of fatty acid release in glioblastoma cells by caffeine.
Caffeine, a well-known behavior stimulant, was found to activate the fatty acid release mechanism in glioblastoma cells. The enhancement of the liberation of fatty acids from esterified complex lipids by caffeine was time dependent. Cell density had a strong influence on the responsiveness to caffeine. The mobilization of unsaturated fatty acids were preferentially stimulated by caffeine. Therefore, caffeine may alter membrane structure and enhance eicosanoid biosynthesis.
D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001692:Biological Transport / Q000187:drug effects; D002110:Caffeine / Q000494:pharmacology*; D002478:Cells, Cultured; D005227:Fatty Acids / Q000378:metabolism*; D005910:Glioma / Q000378:metabolism*; D007700:Kinetics; D019301:Oleic Acid; D009829:Oleic Acids / Q000378:metabolism; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000378:metabolism; D013329:Structure-Activity Relationship
D001095:Arachidonic Acids; D005227:Fatty Acids; D009829:Oleic Acids; D010169:Palmitic Acids; D016718:Arachidonic Acid; D019301:Oleic Acid; D019308:Palmitic Acid; D002110:Caffeine