title: Studies on the pharmacologic manipulation of suppressor cells associated with impaired immunoglobulin production.
abstract: Several agents were tested for their potential to reverse the suppression of normal IgG and IgM production mediatd by human cord T cells and cells from patients with agammaglobulinemia. No reversal of suppression was observed with in vitro incubation of co-cultured normal and immune-deficiency suppressor cells with cimetidine, lithium, or levamisole. Allogeneic helper factor prepared from normal mononuclear cells was able to overcome the suppression of normal IgG production mediated by cord T cells but did not overcome suppression of IgG or IgM production mediated by suppressor cells from agammaglobulinemic patients.
mesh_terms: D000361:Agammaglobulinemia / Q000276:immunology; D002927:Cimetidine / Q000494:pharmacology; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007075:Immunoglobulin M / Q000096:biosynthesis*; D007978:Levamisole / Q000494:pharmacology; D008094:Lithium / Q000494:pharmacology; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects*
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007978:Levamisole; D002927:Cimetidine; D008094:Lithium