The growth hormone responses to L-dopa and TRH in acromegaly.
The GH responses to TRH and L-dopa were investigated in 14 Indian and African patients with untreated acromegaly. A positive response to L-dopa (greater than 50% change from basal) was obtained in 6 of the 14 patients tested while a positive response to TRH (greater than 100% change from basal) was found in 5 of 12 patients tested. While 9 patients responded to at least one agent, only 2 had a positive response to both agents. Positive responders appeared to be hyper-prolactinemic and have evidence of abnormal glucose tolerance as compared to nonresponders.
D000172:Acromegaly / Q000503:physiopathology*; D000328:Adult; D000349:Africa / Q000208:ethnology; D000368:Aged; D005260:Female; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007194:India / Q000208:ethnology; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D012636:Secretory Rate / Q000187:drug effects; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D007980:Levodopa; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D013006:Growth Hormone