Effect of lidoflazine on cerebral blood flow following twelve minutes total cerebral ischemia.
Lidoflazine, a calcium channel blocker, was administered to dogs following twelve minutes of cerebral ischemia, induced by aortic cross-clamping. The effects of lidoflazine (1 mg/kg i.v.) on cerebral blood flow following ischemia was studied in 15 anesthetized, mechanically ventilated dogs. Cerebral blood flow was measured with the radiolabelled microsphere technique before and 10, 30, 60, 90 and 150 minutes following ischemia. Cerebral blood flow increased in all brain regions following ischemia, but by 60 minutes had decreased to control values. Lidoflazine had no effect on this reperfusion phenomenon, or on the distribution of blood flow within the brain. Regional cerebral blood flow was also not altered by lidoflazine therapy. Our data demonstrate that this dose of lidoflazine has no effect on regional or total cerebral blood flow following 12 minutes of cerebral ischemia in dogs. These data do not support perfusion preservation as a mechanism of amelioration of neurologic injury after ischemia by this calcium channel blocker.
D000818:Animals; D002545:Brain Ischemia / Q000097:blood / Q000503:physiopathology*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004285:Dogs; D005260:Female; D008013:Lidoflazine / Q000494:pharmacology*; D008297:Male; D010100:Oxygen / Q000097:blood; D010879:Piperazines / Q000494:pharmacology*; D013997:Time Factors
D002121:Calcium Channel Blockers; D010879:Piperazines; D002245:Carbon Dioxide; D008013:Lidoflazine; D010100:Oxygen