Effect of TRH on plasma arginine vasopressin.
Effect of thyrotropic releasing hormone (TRH) on plasma arginine vasopressin (AVP) was studied in human subjects. All 7 normal controls and 2 hypothyrotropic hypothyroid subjects failed to show any rise of AVP on TRH administration. The 4 primary hypothyroid subjects had elevated basal AVP level and showed further elevation on TRH administration. Our data suggests that elevated TRH in primary hypothyroid subjects may act directly as a nonosmotic stimulus or modulate the osmoreceptor and hypothalamic neurohypophyseal system for AVP release.
D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood* / Q000378:metabolism; D004285:Dogs; D000882:Haplorhini; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000378:metabolism; D007037:Hypothyroidism / Q000097:blood* / Q000378:metabolism; D011817:Rabbits; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone / Q000502:physiology
D001127:Arginine Vasopressin; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin