Release of discrete interferons by cytotoxic T lymphocytes in response to immune and nonimmune stimuli.
We have examined the potential of murine cytotoxic T lymphocytes (CTL) to synthesize both IFN-gamma and IFN-alpha, beta by using three cloned antigen-reactive CTL lines. These lines, which produce IFN-gamma in an antigen-specific manner or after stimulation with mitogen, were also found to produce IFN-alpha, beta upon nonspecific contact with Newcastle disease virus. The requirement for viral integrity in this process has been examined. Virus infectivity was not necessary to stimulate the release of IFN-alpha, beta from CTL, but acid-inactivation of virus abrogated its IFN-inducing property.
D000818:Animals; D002999:Clone Cells / Q000378:metabolism; D003208:Concanavalin A / Q000494:pharmacology; D007369:Interferon Inducers / Q000276:immunology* / Q000494:pharmacology; D007370:Interferon Type I / Q000096:biosynthesis*; D007371:Interferon-gamma / Q000096:biosynthesis*; D007519:Isoantigens / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009522:Newcastle disease virus / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000378:metabolism*
D007369:Interferon Inducers; D007370:Interferon Type I; D007519:Isoantigens; D003208:Concanavalin A; D007371:Interferon-gamma