Combined immunochemical and electrophoretic determinations of proteins in paired serum and cerebrospinal fluid samples.
Albumin and immunoglobulin G were simultaneously determined in paired serum and cerebrospinal fluid samples from healthy volunteers. The albumin quotient and the IgG index were calculated to establish normal values. High-resolution electrophoresis was also performed with the same samples and the electrophoretic patterns were correlated with the numerical values to improve the reliability of the test results. Representative examples from abnormal conditions are also shown, to illustrate the increased accuracy and useful applications of this combined analysis in the diagnosis of neurological conditions.
D000328:Adult; D000368:Aged; D000418:Albumins / Q000134:cerebrospinal fluid; D001797:Blood Protein Electrophoresis / Q000379:methods; D001798:Blood Proteins / Q000032:analysis*; D001812:Blood-Brain Barrier; D002493:Central Nervous System Diseases / Q000097:blood / Q000134:cerebrospinal fluid; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D004587:Electrophoresis, Agar Gel; D005260:Female; D006801:Humans; D005779:Immunodiffusion / Q000379:methods; D007074:Immunoglobulin G / Q000032:analysis / Q000134:cerebrospinal fluid; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012709:Serum Albumin / Q000032:analysis
D000418:Albumins; D001798:Blood Proteins; D002556:Cerebrospinal Fluid Proteins; D007074:Immunoglobulin G; D012709:Serum Albumin