[Role of calcium ions in the evolution of the anticonvulsant effect of taurine].
The decreased microsomal Ca++Mg++ATPase  activity and lowered level of Ca++ binding by the brain cortex microsomes in seizure prone rats as compared with normal animals have been revealed. Taurine increases these parameters in experiments in vitro. Injection of taurine into the penicillin-provoked epileptogenic focus prevents the seizure reaction in rabbits. This effect is not observed after injection of taurine together with EGTA. The data obtained demonstrate the important role of calcium ions in the anticonvulsant action of taurine.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D008861:Microsomes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D010400:Penicillin G; D011817:Rabbits; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy; D013045:Species Specificity; D013654:Taurine / Q000494:pharmacology* / Q000627:therapeutic use
D000927:Anticonvulsants; D013654:Taurine; D000252:Calcium-Transporting ATPases; D008274:Magnesium; D010400:Penicillin G; D002118:Calcium
Rol' ionov kal'tsiia v razvitii protivosudorozhnogo éffekta taurina.