Genetic control of the immune response to haemoglobin. V. Production and characterization of A beta restricted T cell lines and clones.
Monoclonal anti-Ia inhibition experiments were conducted to confirm and extend genetic mapping data of I-A gene control of immunity to human haemoglobin (Hb). It was found that the A beta gene is of critical importance in conferring immunity to the alpha-chain and beta-chain subunits of Hb. A possible involvement of I-E region genes in B10.D2 mice to beta-chain is discussed. Through the use of an alpha-chain specific T cell clone data, is obtained indicating that an intact Ia.8+ A beta chain is necessary for antigen presentation in vitro.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000502:physiology; D002460:Cell Line; D002874:Chromosome Mapping; D002999:Clone Cells; D005802:Genes, MHC Class II; D006454:Hemoglobins / Q000276:immunology*; D008285:Major Histocompatibility Complex; D051379:Mice; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D006454:Hemoglobins