[Glycogen distribution in rat hepatocyte populations after a single exposure to 4-dimethylaminoazobenzine and subsequent injections of phenobarbital].
7 day after a single interperitoneal injection of carcinogen 4-dimethylaminoazobenzen (DAB), a little number of cells with high glycogen contents was found in parallel with a decreased glycogen content in most isolated hepatocytes. 1.5 months after DAB injection, the normal distribution of glycogen content was seen restored in hepatocytes. The treatment of rats with phenobarbital (6 PhB injections 7 days after DAB application) blocked the restoration of the normal glycogen distribution. 2 months after the last PhB injection (3 months after DAB injection) an increased glycogen content was found in the smallest hepatocytes.
D000818:Animals; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D000091402:Prohibitins; D051381:Rats; D013997:Time Factors; D004124:p-Dimethylaminoazobenzene / Q000494:pharmacology*
D008112:Liver Glycogen; C000717332:Phb protein, rat; D000091402:Prohibitins; D004124:p-Dimethylaminoazobenzene; D010634:Phenobarbital
Raspredelenie glikogena v populiatsiiakh gepatotsitov krys posle odnokratnogo vozdeĭstviia 4-dimetilaminoazobenzolom i posleduiushchikh in"ektsiĭ fenobarbitala.