Subgroup analysis of BL-cell lines with polyclonal BL-specific antibodies.
A Burkitt's lymphoma (BL)-specific antibody (anti-GP70), previously described, was used to analyse 22 different BL-cell lines. The results indicated specificity of antibodies to lines that contain both surface membrane Ig (SmIg) and cytoplasmic Ig (CyIg). BL-cell lines derived from more immature B cells that do not have SmIg but rather have only CyIg were negative. A comparative study with antibody to common ALL antigen (CALLA) and to another BL-specific antigen (BLA) revealed coexpression of GP70 with those two antigens, but no identity between them.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000276:immunology*; D000944:Antigens, Differentiation, B-Lymphocyte; D000951:Antigens, Neoplasm / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis; D001402:B-Lymphocytes / Q000276:immunology; D002051:Burkitt Lymphoma / Q000145:classification / Q000276:immunology*; D002454:Cell Differentiation; D002460:Cell Line; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D011817:Rabbits
D000912:Antibodies, Neoplasm; D000944:Antigens, Differentiation, B-Lymphocyte; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D006023:Glycoproteins