Prevention of cyclophosphamide cystitis with 2-mercaptoethane sodium sulfonate: a histologic study.
The ability of 2-mercaptoethane sodium sulfonate to prevent histologic damage to the bladder from cyclophosphamide was studied. Male rats receiving 2-mercaptoethane sodium sulfonate in conjunction with cyclophosphamide had a statistically significant decrease in ulceration, inflammation and edema of the bladder compared to those treated with cyclophosphamide alone. Most bladders of animals given prophylactic 2-mercaptoethane sodium sulfonate with a dose of cyclophosphamide were histologically indistinguishable from controls receiving neither drug. The relevance of these findings to the short and long-term effects of cyclophosphamide on the urothelium is discussed.
D000818:Animals; D003520:Cyclophosphamide / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D003556:Cystitis / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000473:pathology; D008297:Male; D008623:Mercaptoethanol / Q000031:analogs & derivatives*; D015080:Mesna / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D014456:Ulcer / Q000473:pathology; D001743:Urinary Bladder / Q000187:drug effects / Q000473:pathology; D001745:Urinary Bladder Diseases / Q000473:pathology
D008623:Mercaptoethanol; D003520:Cyclophosphamide; D015080:Mesna