Effects of growth hormone on the factor VIII complex in patients with growth hormone deficiency.
Factor VIII activity (VIII C), factor VIII coagulant antigen (VIII C:Ag), factor VIII-related antigen (VIII R:Ag), Ristocetin cofactor (R:Cof), and growth hormone were studied in eight children with growth hormone deficiency prior to, and 60, 120, and 180 minutes after administration of human growth hormone (Crescormone, Kabi), 4 U/m2. Growth hormone has been administered for 1.0 to 6.8 years but was stopped one week prior to this investigation. Basal levels of VIII C, VIII C:Ag, VIII R:Ag, and R:Cof were within the normal limits. After administration of human growth hormone, VIII C, VIII C:Ag, VIII R:Ag, and R:Cof showed a significant rise. Our study shows that growth hormone is not necessary to maintain the basal levels of the factor VIII complex within the normal limits. However, out data suggest that growth hormone has some influences on the levels of the factor VIII complex. The mechanisms for the rise of the factor VIII complex--whether this is a direct effect of growth hormone or not--are not clear at this point.
D000293:Adolescent; D000941:Antigens / Q000378:metabolism; D002648:Child; D005167:Factor VII / Q000276:immunology / Q000378:metabolism; D005169:Factor VIII / Q000378:metabolism*; D005260:Female; D013006:Growth Hormone / Q000172:deficiency* / Q000494:pharmacology; D006801:Humans; D008297:Male; D008970:Molecular Weight
D000941:Antigens; C031500:factor VII related antigen; D005167:Factor VII; D005169:Factor VIII; D013006:Growth Hormone