title: The relationships of neuroendocrine tests in endogenous depression.
abstract: Amphetamine induced growth hormone (GH) response (Study 1) and TRH induced TSH response (Study 2) were assessed in patients with endogenous depression (n = 20 and n = 22, respectively), who underwent a dexamethasone suppression test (DST) on the following day. The GH response to the amphetamine was significantly lower in the group of depressed patients than in the healthy controls (n = 13). There was no difference between the DST nonsuppressors (n = 12) and suppressors (n = 8) in the GH peak values. This data strongly suggests that the two tests are independent from each other. There was no significant relationship between the DST and TRH-TSH results. Patients with blunted TSH response to TRH have had significantly higher cerebrospinal fluid 5-HIAA levels.
mesh_terms: D000328:Adult; D000661:Amphetamine; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis*; D003907:Dexamethasone; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008875:Middle Aged; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone
chemical_list: D013973:Thyrotropin-Releasing Hormone; D003907:Dexamethasone; D013972:Thyrotropin; D013006:Growth Hormone; D000661:Amphetamine; D006854:Hydrocortisone