Disposition of N-vinyl-2-pyrrolidinone in the rat.
The disposition of N-[14C-vinyl]-2-pyrrolidinone was studied in male Sprague-Dawley rats following a single iv injection. Plasma levels of the intact compound dropped rapidly within the first 6 hours after dosing with a half life of 1.90 hours. Urinary excretion by 12 hours represented 74.9% of a 5 microCi dose while 18.7% was excreted into the bile by 6 hours. 14C-activity attributed to the intact compound was found to be less than 0.59% of the dose in the urine and less than 0.46% in the bile. Tissue distribution studies showed that the liver and small intestines and contents contained the highest accumulation of 14C-activity up to 6 hours after administration of N-[14C-vinyl]-2-pyrrolidinone. Urine analyses performed for metabolite elucidation indicated that 12% of the radioactivity dosed was incorporated into acetate and the major remaining portion in species which appeared to be water soluble acidic compounds.
D000818:Animals; D001646:Bile / Q000378:metabolism; D002245:Carbon Dioxide / Q000378:metabolism; D002855:Chromatography, Thin Layer / Q000379:methods; D005243:Feces / Q000032:analysis; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011760:Pyrrolidinones / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D011760:Pyrrolidinones; D002245:Carbon Dioxide; C042670:N-vinyl-2-pyrrolidinone