Lesion-induced DA supersensitivity in aging C57BL/6J mice.
Lesion-induced dopaminergic supersensitivity was investigated in 4-, 10-, and 28-month-old C57BL/6J mice. Apomorphine-induced rotational behavior was examined 5, 10, and 20 days after destruction of the dopamine-containing nigro-striatal pathway by intrastriatal infusion of 6-OHDA. No major differences between ages were observed in the extent or rate of development of contralateral rotation. It is concluded that age-differences in dopaminergic supersensitization are dependent upon the nature and/or severity of the sensitizing stimulus.
D000375:Aging; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000254:growth & development*; D004298:Dopamine / Q000502:physiology*; D007839:Functional Laterality; D006892:Hydroxydopamines / Q000633:toxicity; D051379:Mice; D008810:Mice, Inbred C57BL; D009043:Motor Activity / Q000187:drug effects*; D016627:Oxidopamine; D012399:Rotation; D013378:Substantia Nigra / Q000187:drug effects / Q000254:growth & development*
D006892:Hydroxydopamines; D016627:Oxidopamine; D004298:Dopamine