title: Supply and need of factor VIII concentrates.
abstract: Demand for factor VIII varies greatly and exceeds supply in many places. Logical analysis of this difficult situation has been undertaken by observing actual usage, calculating potential need, and analysing factors which limit or influence production and distribution. Usage exceeds production potential in some places. It is concluded that factor VIII production/usage in the range of 20 000-60 000 IU per hemophilia A patient per year is both feasible and adequate. Production/use below 10 000 IU is not adequate. Production above 60 000 IU is not practicable using current technology.
mesh_terms: D005169:Factor VIII / Q000008:administration & dosage / Q000302:isolation & purification / Q000627:therapeutic use*; D006467:Hemophilia A / Q000188:drug therapy*; D006801:Humans; D012709:Serum Albumin / Q000302:isolation & purification
chemical_list: D012709:Serum Albumin; D005169:Factor VIII