Induction and selection of drug resistant mutants of Plasmodium falciparum.
Conditions for mutagenizing Plasmodium falciparum in culture with the mutagen N-methyl-N'-nitro-N-nitrosoguanidine have been established. Parasite mutants resistant to aphidicolin, cycloheximide and sinefungin have been selected and subcloned.
D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D016590:Aphidicolin; D003513:Cycloheximide / Q000494:pharmacology; D004224:Diterpenes / Q000494:pharmacology; D004351:Drug Resistance; D009154:Mutation; D010963:Plasmodium falciparum / Q000235:genetics*; D012641:Selection, Genetic
D004224:Diterpenes; D016590:Aphidicolin; D003513:Cycloheximide; D000241:Adenosine; C006235:sinefungin