[Bacteriological investigations with a new Semisynthetic oxy-beta-lactam antibiotic LY 127935 (AUTHOR'S TRANSL)].
The antimicrobial activity of a new oxy-beta-lactam antibiotic LY 127935 against 1066 strains of gram-negative and gram-positive bacterial was evaluated in comparison to cephalothin. The antibiotic has a very wide spectrum and is exceptionally active, in particular against gram-negative rods. It is also active against multiresistant problem strains found in intensive care units (Enterobacter cloacae, Serratia marcescens, indole-positive Proteus), and proved to be quite effective against Pseudomonas aeruginosa. Although LY 127935 is effective against Staphylococcus aureus, cephalothin is superior. Its use is not indicated against Streptococcus faecalis.
D001419:Bacteria / Q000187:drug effects*; D002511:Cephalosporins / Q000494:pharmacology*; D002512:Cephalothin / Q000494:pharmacology; D002513:Cephamycins / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009070:Moxalactam
D002511:Cephalosporins; D002513:Cephamycins; D002512:Cephalothin; D009070:Moxalactam
Bakteriologische Untersuchungen mit einem neuen halbsynthetischen Oxy-Beta-Laktam-Antibiotikum LY 127935.