title: Human health effects of selected pesticides, chloroaniline derivatives.
abstract: The health effects of two pesticides, chlordimeform and propanil, are discussed. Chlordimeform and 2-methyl-4-chloroaniline, a major metabolite of chlordimeform, cause severe hemorrhagic cystitis in humans. In cats, however, only a mild effect on the bladder was noted. The herbicide propanil has produced chloracne in humans, and along with 3,4-dichloroaniline, hyperkeratosis in rabbits. The contaminants 3,4,3',4'-tetrachloroazobenzene and 3,4,3',4'-tetrachloroazoxybenzene are responsible for the chloracnegenic characteristics of propanil, 3,4-dichloroaniline, and methazole.
mesh_terms: D000152:Acne Vulgaris / Q000139:chemically induced; D000578:Amidines / Q000506:poisoning*; D000813:Anilides / Q000633:toxicity*; D000818:Animals; D002415:Cats; D056486:Chemical and Drug Induced Liver Injury; D002742:Chlorphenamidine / Q000031:analogs & derivatives / Q000506:poisoning*; D005260:Female; D006801:Humans; D007642:Keratosis / Q000139:chemically induced; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced; D011411:Propanil / Q000633:toxicity*; D011817:Rabbits; D001745:Urinary Bladder Diseases / Q000139:chemically induced*
chemical_list: D000578:Amidines; D000813:Anilides; D011411:Propanil; D002742:Chlorphenamidine