title: Acute hepatic failure in children.
abstract: Many diseases may present as acute hepatic failure in the pediatric age group, including viral hepatitis A and B, adverse drug reactions, both toxic and "hepatitic," and inherited metabolic disorders such as tyrosinemia, alpha 1 antitrypsin deficiency, and Wilson's disease. Management is primarily supportive, with care taken to anticipate the known complications of hepatic failure. Few "curative" therapies are known, although attempts at stimulating hepatic regeneration may be helpful.
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects; D000208:Acute Disease; D056486:Chemical and Drug Induced Liver Injury; D002648:Child; D002675:Child, Preschool; D006501:Hepatic Encephalopathy / Q000175:diagnosis; D006506:Hepatitis A / Q000175:diagnosis; D006509:Hepatitis B / Q000175:diagnosis; D006526:Hepatitis C / Q000175:diagnosis; D006527:Hepatolenticular Degeneration / Q000175:diagnosis; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007244:Infectious Mononucleosis / Q000175:diagnosis; D008107:Liver Diseases / Q000175:diagnosis* / Q000209:etiology / Q000628:therapy; D008661:Metabolism, Inborn Errors / Q000175:diagnosis; D010672:Phenytoin / Q000009:adverse effects; D019896:alpha 1-Antitrypsin Deficiency
chemical_list: D000082:Acetaminophen; D010672:Phenytoin