Intestinal uptake and metabolism of auranofin, a new oral gold-based antiarthritis drug.
Auranofin, 2,3,4,6-tetra-O-acetyl-1-thio-beta-D-glucopyranosato-S-(triethy lphosphine)- gold(I), an experimental antiarthritis pharmaceutical, metabolized in contact with hamster or rat gut wall to yield the deacetylated form of the drug. This product, 1-thio-beta-D-glucopyranosato-S-(triethylphosphine)gold(I), passed through hamster or rat intestinal wall in an everted gut experiment. The metabolite was separated by high-performance liquid chromatography and characterized by retention time, chemical reactivity to yield a known product, and comparison to a synthetic sample of the metabolite.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism*; D001310:Auranofin; D006051:Aurothioglucose / Q000031:analogs & derivatives* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D006224:Cricetinae; D006046:Gold / Q000031:analogs & derivatives*; D007408:Intestinal Absorption; D008647:Mesocricetus; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D006051:Aurothioglucose; D001310:Auranofin; D006046:Gold