Veno-occlusive disease and peliosis of the liver after thorotrast administration.
A case of veno-occlusive disease and peliosis of the liver without coexisting liver malignancy 35 years after thorotrast administration is presented. In the liver four main widely distributed lesions were found: Veno-occlusive disease (VOD), peliosis, fibrosis and thorotrast deposits. Whether the VOD and the peliotic lesions are pathogenetically related or totally independent cannot be determined in the present case. However, the VOD and the peliosis are possibly related to the protracted alpha-emitting effect of thorotrast deposited in the liver parenchyma.
D000512:Alpha Particles; D006502:Budd-Chiari Syndrome / Q000139:chemically induced* / Q000150:complications; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D006801:Humans; D008099:Liver / Q000032:analysis / Q000187:drug effects* / Q000473:pathology; D008875:Middle Aged; D010382:Peliosis Hepatis / Q000139:chemically induced* / Q000150:complications; D013154:Spleen / Q000473:pathology; D013911:Thorium Dioxide / Q000009:adverse effects* / Q000032:analysis; D013997:Time Factors
D013911:Thorium Dioxide