Sustained release nitroglycerin improves myocardial thallium-201 images in men with coronary artery disease.
Ten men with coronary disease and angina-limited exercise participated in a study of the effects of sustained release nitroglycerin capsules on exercise performance and myocardial thallium images. Dose titration to ascertain the maximally tolerated dose, 6.5 to 26 mg orally four times a day, followed by double-blind, placebo-controlled cross-over treatment was undertaken. Following the administration of sustained release nitroglycerin exercise performance and exercise thallium images improved and appeared to remain so for four hours.
D000284:Administration, Oral; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D005080:Exercise Test; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage* / Q000627:therapeutic use; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013793:Thallium
D003692:Delayed-Action Preparations; D011868:Radioisotopes; D013793:Thallium; D005996:Nitroglycerin