[Cardiovascular responses of the rat to a prostaglandin endoperoxide analog].
In the anaesthetized rat, injection of the prostaglandin endoperoxide analog, U 44069, in the right ventricle is vasopressor both in the pulmonary and the systemic circulation. When a moderate dose is used, the hypertensive response of the systemic vascular bed changes in an hypotension. The toxicity seems to be cumulative. At high doses, a vascular collapse is observed sometimes with pulmonary oedema. These findings correlate with the EKG pattern typical for an acute cor pulmonale.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology* / Q000633:toxicity; D011654:Pulmonary Edema / Q000139:chemically induced; D051381:Rats
D011450:Prostaglandin Endoperoxides, Synthetic
Réponses cardiovasculaires du rat à un analogue des endoperoxydes prostaglandiniques.