Study of the imprinting and overlap of insulin and concanavalin-A at the receptor level in a protozoan (Tetrahymena) model system.
In a protozoan (Tetrahymena) model system, insulin treatment produced a long-term imprinting which upon re-exposure to the hormone resulted in an enhanced binding of the hormone. Insulin pretreatment produced similar effect with regard to the binding of concanavalin-A. Concanavalin-A could only induce a short-term imprinting for itself and was not capable at all of inducing imprinting for insulin. Based on the results of this study it appears that the binding of the sugar component of the receptor, which can be achieved also by lectin, is not sufficient to induce imprinting but the whole (hormone) molecule is needed.
D000818:Animals; D003208:Concanavalin A / Q000378:metabolism* / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism* / Q000494:pharmacology; D008954:Models, Biological; D011972:Receptor, Insulin / Q000187:drug effects / Q000378:metabolism*; D011952:Receptors, Concanavalin A / Q000187:drug effects / Q000378:metabolism*; D013769:Tetrahymena pyriformis / Q000378:metabolism*; D013997:Time Factors
D007328:Insulin; D011952:Receptors, Concanavalin A; D003208:Concanavalin A; D006632:Histamine; D011972:Receptor, Insulin