[Trans-catheter embolisation of the spleen with butyl-2-cyanoacrylate. Experimental results and clinical application (author's transl)].
Partial and total trans-catheter embolisation of the spleen with butyl-2-cyanoacrylate-lipiodol in 23 dogs lead to partial necrosis and cicatrisation of the spleen after 3 to 5 weeks. The embolised vessels do not recanalise, but are by-passed by extra- and intra-splenic collaterals. In five animals there was a reduction in the number of erythrocytes; after embolisation there was increase in the number of leucocytes, whereas the thrombocytes were unchanged. The most common complication which occurred in five animals was a 1.5 to 2.5 cm. splenic abscess. The procedure was employed without success in one patient with bleeding oesophageal varices. The procedure was complicated by extensive necrosis of the gastric mucosa. Trans-catheter embolisation of the spleen has significant complications, despite strict asepsis and antibiotic cover. The main indication of the procedure is hypersplenism which cannot be treated surgically.
D000818:Animals; D002015:Bucrylate; D003097:Collateral Circulation; D004285:Dogs; D004621:Embolization, Therapeutic / Q000009:adverse effects / Q000592:standards*; D004932:Esophageal and Gastric Varices / Q000628:therapy; D005753:Gastric Mucosa; D006801:Humans; D006971:Hypersplenism / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000209:etiology; D010538:Peritonitis / Q000209:etiology; D013157:Splenic Artery
D002015:Bucrylate
Transkatheterembolisierung der Milz mit Butyl-2-Cyanoacrylat. Experimentelle Ergebnisse und klinische Anwendung.