[Immunofluorescence studies in stomach and breast carcinomas and benign breast diseases].
A study was made for localization of immunoglobulins and complement components in human malignant tumour tissues. There were not observed characteristical deposits on tumour cells. In a 2nd investigation where indirect immunofluorescence method was used, autologous antibodies to tumour material were not detectable. Only with anti-C3-technique, 2 sera from patients with breast cancer and 1 serum from a patient with mastopathia reacted with breast cancer tissue (allogenic system). However, a lot of autoantibodies of different specifity could be found in sera of tumour patients. The problems of unspecific staining and the occurrence of autoantibodies in tumour sera were discussed.
D000912:Antibodies, Neoplasm / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D001941:Breast Diseases / Q000276:immunology*; D001943:Breast Neoplasms / Q000276:immunology*; D002467:Cell Nucleus / Q000276:immunology; D003166:Complement Activating Enzymes / Q000032:analysis; D015922:Complement C1q; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008928:Mitochondria / Q000276:immunology; D009132:Muscles / Q000276:immunology; D013274:Stomach Neoplasms / Q000276:immunology*
D000912:Antibodies, Neoplasm; D001323:Autoantibodies; D007136:Immunoglobulins; D015922:Complement C1q; D003166:Complement Activating Enzymes
Immunfluorescenz-Untesuchungen bei Magenund Mammakarcinomen sowie gutartigen Mammaerkrankungen.