Unilateral seizures following vincristine intravenous injection.
A case of acute central nervous system toxicity following the intravenous injection of vincristine was observed in a patient treated with a chemotherapy regimen including cyclophosphamide, doxorubicin and prednisone for non-Hodgkin lymphoma. The neurological symptoms consisted of right-sided epileptiform jacksonian seizures limited to the face, that lasted about 10 min, followed by spontaneous recovery. A cerebrospinal fluid study and computed tomographic scan of the brain failed to reveal any central nervous system lymphomatous involvement.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000188:drug therapy; D008875:Middle Aged; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects*
D014750:Vincristine; D004317:Doxorubicin