Measuring the inhibition of TRH-stimulated prolactin by dihydroergocristine (DEC) in man: an indirect assessment of bioavailability.
An indirect method to assess bioavailability of dihydroergocristine-methansulfonate (DEC) is described. The method uses the inhibitory effect of DEC on TRH stimulated prolactin production. By means of this method it was possible to investigate the relative bioavailability of DEC tablets versus Diertina liquid. The results show that the relative bioavailability is complete.
D000328:Adult; D001682:Biological Availability; D004088:Dihydroergotoxine / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D008297:Male; D011388:Prolactin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D004088:Dihydroergotoxine; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin