A histological study on microthrombi in autopsy cases of DIC.
Microthrombi in 43 untreated and 26 treated cases of DIC were studied histologically and immunohistochemically. In the untreated cases, four types of microthrombi (intraluminal microthrombi with or without fibroblastic and/or smooth muscle cell reaction) were identified. Microthrombi in the former three types showed various degrees of thrombolysis. Failure of thrombolysis seemed to lead the organization of microthrombi. These morphological findings were considered to indicate the course of DIC and the degree of disappearance of the microthrombi in DIC. Microthrombi in the hepatic sinusoids and glomerular capillaries were studied with special reference to the removal processes of the microthrombi. Pathogenesis of renal cortical necrosis in DIC was also discussed. The number of microthrombi was markedly decreased by heparin and gabexate mesilate treatment. The incidences of microthrombi in the liver, kidney, lung, and heart were compared in the two treated groups.
D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D016670:Gabexate; D006146:Guanidines / Q000627:therapeutic use; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007678:Kidney Glomerulus / Q000473:pathology; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D011480:Protease Inhibitors / Q000627:therapeutic use; D013927:Thrombosis / Q000473:pathology*
D006146:Guanidines; D011480:Protease Inhibitors; D016670:Gabexate; D006493:Heparin