[Acute hypotensive effect of a central dopaminergic agonist, piribedil, administered intravenously in the normotensive human].
Ten normotensive patients including 5 parkinsonian and 5 dystonic patients received 3 mg piribedil intravenously over a 15 min period. This dopamine receptor agonist rapidly induced a fall in blood pressure together with a simultaneous reduction in heart rate and temperature. No change was observed when patients (four) were pretreated with a dopamine receptor blocking agent, haloperidol. It is concluded that acute dopamine receptor stimulation leads to a decrease in blood pressure. The hypotension could be centrally-mediated since the hypothermia, considered to be central in origin, parallels the blood pressure and heart rate changes.
D000959:Antihypertensive Agents; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy; D010879:Piperazines / Q000494:pharmacology*; D010891:Piribedil / Q000494:pharmacology*; D011954:Receptors, Dopamine / Q000187:drug effects*
D000959:Antihypertensive Agents; D010879:Piperazines; D011954:Receptors, Dopamine; D010891:Piribedil
Action hypotensive aiguë d'un agoniste dopaminergique central, le piribédil, administré par voie veineuse chez l'homme normotendu.