title: How is it decided when to conduct a large-scale caries clinical trial?
mesh_terms: D002327:Cariostatic Agents / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003257:Consumer Product Safety; D003362:Cost-Benefit Analysis; D003731:Dental Caries / Q000191:economics / Q000517:prevention & control*; D005069:Evaluation Studies as Topic; D006801:Humans; D012107:Research Design; D012306:Risk
chemical_list: D002327:Cariostatic Agents