Renal vein thrombosis in systemic lupus erythematosus: association with the "lupus anticoagulant".
Two patients with lupus erythematosus and renal vein thrombosis are described. Both patients had the "lupus anti-coagulant" in their serum. It is postulated that in these patients the clotting tendency could be favoured by a cross reaction of the "lupus anti-coagulant" with phospholipids in the endothelial cell membrane, resulting in inhibition of prostacyclin release.
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors* / Q000494:pharmacology / Q000502:physiology; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D016682:Lupus Coagulation Inhibitor; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications* / Q000473:pathology; D010743:Phospholipids / Q000037:antagonists & inhibitors; D012082:Renal Veins; D013927:Thrombosis / Q000209:etiology* / Q000473:pathology
D001779:Blood Coagulation Factors; D016682:Lupus Coagulation Inhibitor; D010743:Phospholipids