[Histochemical detection of tissue changes using tetrazolium salts of differing nitrosensitivity].
By histochemical detection of succinic dehydrogenase in the myocardium of rats, it was shown that cell alterations induced by isoprenaline can be demonstrated in different qualities by the use of the atypical formazans of suitable nitro-monotetrazolium salts. The chemical structure of these nitro-monotetrazolium salts defines their different trends ("nitro-sensitivity") to react in their atypically-coloured formazans under histochemical conditions. A range of nitro-monotetrazolium salts with graded nitro-sensitivities is stated for improved histochemical detection of cell and tissue injuries.
D000818:Animals; D005562:Formazans / Q000032:analysis; D006321:Heart / Q000187:drug effects; D006651:Histocytochemistry / Q000379:methods*; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000201:enzymology* / Q000473:pathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D013385:Succinate Dehydrogenase / Q000032:analysis*; D013778:Tetrazolium Salts
D005562:Formazans; D013778:Tetrazolium Salts; D013385:Succinate Dehydrogenase; D007545:Isoproterenol
Zum histochemischen Nachweis von Gewebsalterationen durch Tetrazoliumsalze unterschiedlicher Nitrosensitivität.