title: [Severe phosphate depletion in uncontrolled diabetes mellitus (case report)].
abstract: The appearance of the syndrome of phosphate depletion (plasma phosphorus level: 0,12 mmol/l) in a patient with uncontrolled diabetes mellitus is reported. The inorganic phosphorus is essential for the resynthesis of 2,3-DPG and ATP, therefore phosphate depletion results in tissue hypoxia and decrease of energy rich phosphate with disturbances of various organ systems. The causes, pathogenetic mechanisms and the clinical signs and symptoms are discussed. Regular controlls of plasma phosphorus levels and a prophylactic substitution of phosphate are recommended.
mesh_terms: D000328:Adult; D001786:Blood Glucose / Q000378:metabolism*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D016883:Diabetic Ketoacidosis / Q000097:blood; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D010710:Phosphates / Q000097:blood*; D012131:Respiratory Insufficiency / Q000097:blood
chemical_list: D001786:Blood Glucose; D010710:Phosphates
vernacular_title: Schwere Phosphatdepletion bei entgleistem Diabetes mellitus (Fallbericht).