Further characterization of human suppressor cells generated in mixed lymphocyte cultures.
Suppressor cells can be generated in mixed lymphocyte cultures (MLC). The studies reported here show that the cells responsible for suppression belong to relatively radioresistant T cells. Furthermore, to generate suppressor cells in MLC, the cells must be able to proliferate, while this is not necessary for expression of the suppressive capacity.
D002455:Cell Division; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000166:cytology / Q000276:immunology* / Q000528:radiation effects; D014965:X-Rays