title: [Possible causes of change in collagen metabolism in aging].
abstract: At the beginning the different collagen types and their occurrence will be illustrated. The present known collagen changes - due to age alterations - will then be demonstrated and explained with examples: 1. Elasticity decrease of the collagen fibre due to stronging of the cross-links 2. Decrease of turnover 3. Increase of hydroxyproline and hydrolysine ; decrease of proline and lysine 4. Increase of the non-enzymatic glycosylation. The following comes into question as possible cause for age-changes to such degrees: decrease of water portion, decrease and change of the glycosaminoglycan-types, radical-formation, decrease of cell numbers and activity, immunity defect and general age changes.
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging; D000818:Animals; D001842:Bone and Bones; D002648:Child; D003094:Collagen / Q000378:metabolism*; D003238:Connective Tissue / Q000378:metabolism; D004548:Elasticity; D005260:Female; D006025:Glycosaminoglycans / Q000378:metabolism; D006801:Humans; D006900:Hydroxylation; D006901:Hydroxylysine / Q000378:metabolism; D006909:Hydroxyproline / Q000097:blood / Q000378:metabolism; D008239:Lysine / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011392:Proline / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000378:metabolism
chemical_list: D006025:Glycosaminoglycans; D006901:Hydroxylysine; D003094:Collagen; D011392:Proline; D008239:Lysine; D006909:Hydroxyproline
vernacular_title: Mögliche Ursachen der Altersveränderung des Kollagenstoffwechsels?