Effects of amiloride on calcium uptake by myocytes isolated from adult rat hearts.
Amiloride at high concentrations inhibits the uptake of Ca by rat heart myocytes containing elevated levels of intracellular Na and retards the development of Ca-dependent hypercontracture in these cells. In contrast, amiloride enhances the net uptake of Ca in Ca-tolerant myocytes containing normal levels of Na. The results suggest that amiloride may inhibit Na-Ca exchange across the sarcolemma of cardiac myocytes.
D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004533:Egtazic Acid / Q000494:pharmacology; D009206:Myocardium / Q000166:cytology* / Q000378:metabolism; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D012508:Sarcolemma / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013997:Time Factors
D011719:Pyrazines; D004533:Egtazic Acid; D000584:Amiloride; D012964:Sodium; D002118:Calcium