title: Effect of ovarian sympathectomy on follicular development during compensatory ovarian hypertrophy in the guinea-pig.
abstract: Selective ovarian sympathectomy was achieved by injecting 6-hydroxydopamine into a surgically closed periovarian bursa on Day 3 of the oestrous cycle (Day 1 = day of oestrus). Control ovaries had the periovarian bursa surgically closed and were injected with solvent. On Day 15 of the cycle, serum was collected for progesterone determination and ovaries were processed for morphometric analysis of follicles. In both control and sympathectomized ovaries remaining after unilateral ovariectomy on Day 3, there was an increase in ovarian weight and an increase in healthy preovulatory follicles (greater than 700 microns diam.). Sympathectomy of the ovary remaining after unilateral ovariectomy increased healthy follicles 510-700 microns diameter but decreased the total number of follicles per ovary. In animals bearing both ovaries, unilateral sympathectomy did not affect any of the characteristics measured. Serum progesterone concentrations were unaffected by any of the treatments. These results indicate that adrenergic nerves play a role in follicular dynamics in ovaries undergoing compensatory hypertrophy but are not necessary for compensatory increases in weight and number of preovulatory follicles.
mesh_terms: D000818:Animals; D002369:Castration; D005260:Female; D006168:Guinea Pigs; D006892:Hydroxydopamines; D006984:Hypertrophy; D006080:Ovarian Follicle / Q000254:growth & development* / Q000294:innervation; D010053:Ovary / Q000294:innervation* / Q000473:pathology; D016627:Oxidopamine; D011374:Progesterone / Q000097:blood; D013563:Sympathectomy, Chemical
chemical_list: D006892:Hydroxydopamines; D011374:Progesterone; D016627:Oxidopamine