title: Changes in distribution of mercury and selenium in soluble fractions of rabbit tissues after simultaneous administration.
abstract: The existing states of mercury and selenium in the blood and in soluble fractions of perfused rabbit liver and kidney were studied by gel filtration on Sephadex G-200 1 hr or 24 hr after intravenous injection of mercuric chloride and/or sodium selenite. Both mercury and selenium in the plasma and stroma-free hemolysate were found to exist in the high-molecular weight fraction following simultaneous injection of mercuric chloride and sodium selenite. Patterns in gel filtration of the plasma and the stroma-free hemolysate did not show any significant change between 1 hr and 24 hr after the administration. A similar tendency as described above was obtained with the liver-soluble fraction at 24 hr after injection of mercuric chloride and sodium selenite. A possible role of the high-molecular weight complex, which is quickly formed by the interaction of mercury and selenium in blood stream, in decreasing the acute renal toxicity of inorganic mercury is discussed.
mesh_terms: D000818:Animals; D002850:Chromatography, Gel; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008627:Mercuric Chloride; D008628:Mercury / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism*; D011817:Rabbits; D020887:Selenious Acid; D012643:Selenium / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism*
chemical_list: D008627:Mercuric Chloride; D020887:Selenious Acid; D008628:Mercury; D012643:Selenium