[Acceleration of the synthesis of cardiac adenine nucleotides from adenosine as affected by propranolol].
DL-propranolol, at a dose of 2 mg . l-1, induced in the isolated rat heart an increase in adenine nucleotide synthesis from exogenous 5 microM adenosine (+20%). If supplied during reperfusion following low-flow ischaemia (0.5 ml . min-1, 30 min.), propranolol annulled the decrease in adenosine incorporation (-23%) provoked by ischaemia. When propranolol was given during ischaemia and reperfusion, ATP degradation during the ischaemic period was reduced and adenosine uptake was strongly stimulated on reperfusion (+60%).
D000227:Adenine Nucleotides / Q000096:biosynthesis*; D000241:Adenosine / Q000378:metabolism*; D000244:Adenosine Diphosphate / Q000096:biosynthesis; D000249:Adenosine Monophosphate / Q000096:biosynthesis; D000255:Adenosine Triphosphate / Q000096:biosynthesis; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003327:Coronary Disease / Q000378:metabolism; D005260:Female; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects; D010766:Phosphorylation; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000227:Adenine Nucleotides; D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D011433:Propranolol; D000241:Adenosine
Accélération de la synthèse des nucléotides adényliques cardiaques à partir de l'adénosine sous l'effet du propranolol.