Effect of aflatoxin B1 on brain serotonin and catecholamines in chickens.
A single oral dose of aflatoxin B1 at 3 mg/kg body weight caused a significant increase in brain serotonin (5-HT) in 5-week-old chickens. Norepinephrine (NE) brain concentration significantly decreased, whereas the dopamine (DA) concentration remained unchanged. These results suggest that in modifying the concentrations of biogenic amines in the brain, aflatoxin B1 may affect brain function.
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000633:toxicity*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002395:Catecholamines / Q000378:metabolism*; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D008297:Male; D012701:Serotonin / Q000378:metabolism*
D000348:Aflatoxins; D002395:Catecholamines; D012701:Serotonin; D016604:Aflatoxin B1