[Possible role of vasopressin in ischemic accidents related to tobacco consumption].
Tobacco smoking increases the risk of myocardial infarction and sudden death. When used for diagnostic and therapeutic ends, vasopressin, at low doses, may induce acute ischaemic complications in patients with coronary artery disease. This study showed that in some patients the inhalation of tobacco smoke caused a rise in plasma vasopressin and nicotine-stimulated-neurophysin, a substance easily measured and used as a marker of vasopressin secretion because of the close relationship of the two substances. Twelve out of twenty five subjects presented higher levels of nicotine-stimulated-neurophysin than the normal for the same group before smoking (p less than 0,005): 280 +/- 54 compared to 714 +/- 459 pg/ml. Simultaneous measurement of vasopressin and nicotine-stimulated-neurophysin every 5 minutes in 4 subjects confirmed the parallel changes of these substances during smoking. These results suggest that vasopressin may play a primary role in the acute ischaemic complications of tobacco smoking. The concept of the "vasopressin response" could be used as a biological parameter to identify subjects at "high cardiovascular risk" under the effects of tobacco and so lead to a prophylactic strategy aimed more specifically at these patients.
D003327:Coronary Disease / Q000097:blood / Q000209:etiology*; D006801:Humans; D009481:Neurophysins / Q000097:blood; D012306:Risk; D012907:Smoking; D014667:Vasopressins / Q000097:blood* / Q000502:physiology
D009481:Neurophysins; D014667:Vasopressins
Possible rôle de la vasopressine dans les accidents ischémiques liés à la consommation de tabac.