Gonadotrophin responses to GnRH in precocious puberty treated with GnRH analogue.
The gonadotrophin releasing hormone analogue Buserelin was given by intranasal spray to 13 children with precocious puberty. The LH responses to GnRH reverted to prepubertal levels in the boys on 200-400 micrograms daily of the analogue while doses of 400-1200 micrograms daily were needed to suppress the girls. The significance of this apparent sex difference is uncertain.
D002064:Buserelin / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003864:Depression, Chemical; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D010906:Pituitary Hormone-Releasing Hormones; D011629:Puberty, Precocious / Q000188:drug therapy* / Q000503:physiopathology; D012737:Sex Factors
D010906:Pituitary Hormone-Releasing Hormones; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002064:Buserelin