title: [Mass exchange conditions in penicillin biosynthesis in an industrial fermenter with aerodynamic foam suppressor].
abstract: The mass exchange characteristics of 50 m3 industrial fermentors with aerodynamic foam suppression and the effect of the specific power input on biosynthesis of penicillin were studied. A change in the specific power input from 1.3 to 1.9 kW/m3 had no effect on the level of the antibiotic accumulation when the medium with 8 per cent of lactose was used. An increase in the aeration rate from 1 to 1.2 m3/m3 X min provided a 1.1-fold increase in the penicillin activity of the fermentation broth. The use of the device for aerodynamic foam suppression with a system of automatic control of the partial pressure of dissolved carbon dioxide allowed decreasing 1.22-fold the oil use and increasing the process productivity by 10 per cent.
mesh_terms: D000332:Aerobiosis; D055598:Chemical Phenomena; D002621:Chemistry; D004864:Equipment and Supplies; D005285:Fermentation; D008433:Mathematics; D010313:Partial Pressure; D010400:Penicillin G / Q000096:biosynthesis*; D010408:Penicillium chrysogenum / Q000378:metabolism
chemical_list: D010400:Penicillin G
vernacular_title: Izuchenie usloviĭ massobmena pri biosinteze penitsillina v promyshlennom fermentatore s aérodinamicheskim penogasitelem.