Structure of human factor VIII.
The deduced amino acid sequence of human factor VIII, obtained from the DNA sequence, predicts a mature polypeptide of 2,332 amino acids containing a triplicated domain structure. The polypeptide has 35% sequence homology with the copper-binding plasma protein, ceruloplasmin. Determination of the thrombin cleavage sites in plasma-derived factor VIII polypeptides allows prediction of the domains involved in the associated activation and inactivation of the protein.
D000595:Amino Acid Sequence; D002570:Ceruloplasmin; D005169:Factor VIII; D006801:Humans; D010446:Peptide Fragments / Q000032:analysis; D011487:Protein Conformation; D011498:Protein Precursors; D013917:Thrombin / Q000378:metabolism
D010446:Peptide Fragments; D011498:Protein Precursors; D005169:Factor VIII; D002570:Ceruloplasmin; D013917:Thrombin