Simultaneous spectrophotometric determination of nifuroxime and furazolidone in pharmaceutical preparations.
Two spectrophotometric methods have been developed for the simultaneous determination of nifuroxime and furazolidone in their pharmaceutical preparations. No preliminary separation step is required in either method. The first, a modified Vierordt method, gives accurate and reproducible results for both drugs. Mean percent recoveries for nifuroxime and furazolidone were 99.50 +/- 1.59 and 100.20 +/- 1.16 (P = 0.05), respectively. This method also gives accurate and reproducible results for the determination of nifuroxime and furazolidone in their pharmaceutical preparations: Tricofuran vaginal suppositories and powder. The second method, which involves the use of the first-derivative curves, gives unreliable results; the reasons for these are discussed.
D004338:Drug Combinations / Q000032:analysis; D005664:Furazolidone / Q000032:analysis*; D009581:Nitrofurans / Q000032:analysis*; D013053:Spectrophotometry; D013056:Spectrophotometry, Ultraviolet
D004338:Drug Combinations; D009581:Nitrofurans; D005664:Furazolidone