Evaluation of the degree of desialylation of serum C1-inactivator and haemopexin.
The calibration curves for evaluating the degree of desialylation of C1-inactivator (sialic acid content 12.5%) and haemopexin (sialic acid content 4%) have been plotted. No desialylation of either glycoprotein occurs in normal subjects. In the patients (liver damage) studied, C1-inactivator is often desialylated, whereas haemopexin is not. In a previous report, we had shown that alpha1-acid glycoprotein is more often desialylated than alpha1-antitrypsin. Thus, it appears that the degree of desialylation of the sialic acid-rich glycoproteins is a more sensitive index of the severity of hepatic injury than that of the sialic acid-poor glycoproteins. This could be due to a defect in the sialylation process during synthesis.
D000328:Adult; D001212:Asialoglycoproteins / Q000097:blood*; D055598:Chemical Phenomena; D002621:Chemistry; D003174:Complement C1 Inactivator Proteins / Q000032:analysis*; D006466:Hemopexin / Q000032:analysis*; D006801:Humans; D005779:Immunodiffusion / Q000379:methods; D008107:Liver Diseases / Q000097:blood; D019158:N-Acetylneuraminic Acid; D012794:Sialic Acids / Q000097:blood*
D001212:Asialoglycoproteins; D003174:Complement C1 Inactivator Proteins; D012794:Sialic Acids; D006466:Hemopexin; D019158:N-Acetylneuraminic Acid