Hyaluronic acid enhances phagocytosis of human monocytes in vitro.
Pretreatment of human blood monocytes with hyaluronic acid for 0.5 hr enhanced significantly their ingestion in vitro of yeast particles opsonized with complement. The enhancement of the phagocytic capacity was dose dependent and maximal in the range of 25-50 micrograms/ml.
D002448:Cell Adhesion / Q000187:drug effects; D002809:Chondroitin Sulfates / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006820:Hyaluronic Acid / Q000494:pharmacology*; D009000:Monocytes / Q000187:drug effects / Q000276:immunology*; D009895:Opsonin Proteins / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects*; D015003:Yeasts / Q000276:immunology
D009895:Opsonin Proteins; D006820:Hyaluronic Acid; D002809:Chondroitin Sulfates