A biological effect on platelets by the minor component of gold sodium thiomalate--a by-product of heat sterilization and exposure to light.
Gold sodium thiomalate as currently used is a mixture probably consisting of small polymers of different structures. The colourless and yellow solutions have been studied in platelets, which had been known to show biological effects of the yellow solution. Only the yellow solution causes ADP dependent platelet aggregation. Platelets treated with the yellow solution contain larger particles (100-700 nm in diameter) compared to a maximal particle size of 40 nm from the colourless solution. The biological differences observed may be due to phagocytosis of the larger components with resultant ADP release and aggregation.
D001696:Biomechanical Phenomena; D001792:Blood Platelets / Q000187:drug effects* / Q000648:ultrastructure; D055598:Chemical Phenomena; D002621:Chemistry; D006052:Gold Sodium Thiomalate / Q000494:pharmacology*; D006358:Hot Temperature; D006801:Humans; D008027:Light; D008854:Microscopy, Electron; D010974:Platelet Aggregation / Q000187:drug effects; D013057:Spectrum Analysis
D006052:Gold Sodium Thiomalate