The combined action of azlocillin and sisomicin in a model simulating the in vivo serum kinetics.
The in vivo serum kinetics of azlocillin and sisomicin were simulated in a new in vitro test model. A strong synergistic effect against Pseudomonas aeruginosa resulted when both compounds were administered simultaneously and eliminated according to their individual half-life values, even when the decreasing drug concentrations exceeded the MICs for only a short period of time. When applied at intervals, neither pretreatment with azlocillin nor with sisomicin blocked the antibacterial activity of the combination partner.
D001390:Azlocillin; D002478:Cells, Cultured; D004357:Drug Synergism; D006207:Half-Life; D006801:Humans; D008954:Models, Biological; D010406:Penicillins / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa; D012853:Sisomicin / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*
D010406:Penicillins; D001390:Azlocillin; D012853:Sisomicin