[3-Methylhistidine as a parameter for the determination of muscle proteolysis in the post-stress syndrome and in diabetes mellitus].
The renal excretion of 3-methylhistidine was measured in healthy human volunteers under different diets. The excretion of 3-methylhistidine and total nitrogen was increased in 8 surgical patients. These findings are referred to an increased proteolysis mainly in the skeletal muscle. In four insulin-dependent diabetic patients (IDDM) the excretion of 3-methylhistidine into urine was increased only when referred to body weight. The interpretation of the 3-methylhistidine/creatinin ratio is discussed. In diabetic patients the total nitrogen excretion seems to be a better parameter for protein turnover than 3-methylhistidine. The data suggest that 3-methylhistidine excretion into urine is a suitable parameter for the determination of muscle protein turnover.
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000652:urine; D016883:Diabetic Ketoacidosis / Q000652:urine*; D004044:Dietary Proteins / Q000008:administration & dosage; D005260:Female; D005767:Gastrointestinal Diseases / Q000601:surgery*; D006639:Histidine / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008762:Methylhistidines / Q000652:urine*; D009124:Muscle Proteins / Q000378:metabolism*; D010288:Parenteral Nutrition; D011183:Postoperative Complications / Q000652:urine*
D004044:Dietary Proteins; D008762:Methylhistidines; D009124:Muscle Proteins; D006639:Histidine; C028118:3-methylhistidine
3-Methylhistidin als Parameter zur Messung der Muskelproteolyse im Postaggressionssyndrom und bei Diabetes mellitus.