The effects of theophylline and salbutamol on right and left ventricular function in chronic bronchitis and emphysema.
We have compared the effects of oral theophylline and salbutamol on right and left ventricular function in twelve patients with chronic bronchitis and emphysema. Right and left ventricular ejection fraction (RVEF and LVEF) were measured using multiple gated radionuclide ventriculography. Theophylline 600 mg and salbutamol 4 mg both produced increases in RVEF and LVEF. There were no significant changes in blood gases after either drug. The clinical significance of the effects of oral bronchodilators on cardiac function in patients with chronic bronchitis and emphysema has yet to be determined.
D000328:Adult; D000368:Aged; D000420:Albuterol / Q000494:pharmacology*; D001991:Bronchitis / Q000097:blood / Q000503:physiopathology*; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output / Q000187:drug effects*; D002908:Chronic Disease; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D011656:Pulmonary Emphysema / Q000097:blood / Q000503:physiopathology*; D013318:Stroke Volume / Q000187:drug effects*; D013806:Theophylline / Q000494:pharmacology*
D002245:Carbon Dioxide; D013806:Theophylline; D000420:Albuterol; D010100:Oxygen