Changes of arachidonic acid in phosphatidylcholine different from other lipids in kidneys of spontaneously hypertensive rats after feeding a linoleic acid-rich diet.
In spontaneously hypertensive rats (SHR) fed a linoleic acid-rich (LAR) diet over 22 weeks blood pressure could not be influenced when compared with SHR on linoleic acid-deficient (LAD) food. On the other hand, normotensive Wistar rats (WR) revealed a significantly lower blood pressure after feeding a LAR diet. The percentages of LA and AA were markedly increased in triglycerides and free fatty acids (FFA) in renal cortex and medulla of LAR-fed SHR and WR in comparison to LAD-fed animals. In renal phosphatidylethanolamine (PE) LA was also increased whereas AA remained unchanged. On the contrary, in phosphatidylcholine (PC) LA was only slightly augmented (in SHR) or even lowered (in WR), AA appearing decreased in SHR but increased in WR. These different changes in PE and PC indicate that individual phospholipids show a dissimilar behavior after dietary interventions, which can be masked by the evaluation of total phospholipids and might be of pathophysiological relevance.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D001794:Blood Pressure; D004041:Dietary Fats / Q000008:administration & dosage; D005227:Fatty Acids / Q000378:metabolism; D006973:Hypertension / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D008041:Linoleic Acids / Q000494:pharmacology*; D050356:Lipid Metabolism; D008297:Male; D010713:Phosphatidylcholines / Q000378:metabolism*; D010714:Phosphatidylethanolamines / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D001095:Arachidonic Acids; D004041:Dietary Fats; D005227:Fatty Acids; D008041:Linoleic Acids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D016718:Arachidonic Acid