Murine resistance to street rabies virus: genetic analysis by testing second-backcross progeny and verification of allelic resistance genes in SJL/J and CBA/J mice.
Intraperitoneal challenge with street rabies virus of second-backcross offspring produced from susceptible females mated with either randomly selected or rabies-resistant first-backcross males indicated that murine resistance is under the influence of the concurrent presence of each of two segregating genes. Furthermore, the greater than or equal to 96% resistance of offspring produced from (SJL X CBA)F1 and (CBA X SJL)F1 hybrids crossed to susceptible A.SW or A/WySn mice demonstrated that resistance genes of SJL/J and CBA/J mice are allelic.
D000483:Alleles; D000818:Animals; D003433:Crosses, Genetic; D004198:Disease Susceptibility; D005260:Female; D005802:Genes, MHC Class II; D007113:Immunity, Innate; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology / Q000382:microbiology*; D011818:Rabies / Q000276:immunology / Q000382:microbiology; D011820:Rabies virus / Q000276:immunology*; D013045:Species Specificity