Assessment of lead stores in children: validation of an 8-hour CaNa2EDTA provocative test.
Twenty-four-hour CaNa2EDTA provocative tests for the assessment of lead stores were successfully performed in 36 asymptomatic children with mild to moderate undue lead absorption (blood lead concentration less than or equal to 69 micrograms/dl and erythrocyte protoporphyrin greater than or equal to 50 micrograms/dl). By comparing lead excretion during the first 8 hours with that excreted during the entire 24-hour test, new criteria have been developed to define positive outcomes. We suggest that the excretion of greater than or equal to 200 micrograms lead per 8 hours or a ratio of urinary lead (micrograms)/CaNa2EDTA administered (mg) greater than or equal to 0.70 after a single intramuscular injection of CaNa2EDTA (500 mg/m2) can identify those children who will respond to chelation treatment with lead diuresis.
D002648:Child; D002675:Child, Preschool; D004492:Edetic Acid; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D006801:Humans; D007223:Infant; D007854:Lead / Q000097:blood / Q000652:urine*; D007855:Lead Poisoning / Q000175:diagnosis*; D008297:Male; D013997:Time Factors
D007854:Lead; D004492:Edetic Acid