Cholinergic learning deficits in the marmoset produced by scopolamine and ICV hemicholinium.
Common marmosets (Callithrix jacchus) were trained to perform daily position discrimination learning tasks in a Wisconsin General Test Apparatus. Acetylcholine receptor blockade with scopolamine was found to impair position learning. Testing on the day after scopolamine treatment suggested that a task learnt under scopolamine was not encoded into long term memory. Acetylcholine depletion achieved by the intraventricular injection of hemicholinium 4 h before testing resulted in a profound impairment of position discrimination learning. It is suggested that central acetylcholine depletion in primates may provide a useful model of senile dementia.
D000818:Animals; D002143:Callitrichinae; D004193:Discrimination Learning / Q000187:drug effects*; D005260:Female; D006426:Hemicholinium 3 / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D008568:Memory / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects* / Q000502:physiology; D012601:Scopolamine / Q000494:pharmacology*
D011950:Receptors, Cholinergic; D006426:Hemicholinium 3; D012601:Scopolamine