title: Clinical evaluation of Tc-99m N,N'-bis(mercaptoacetyl)-2,3-diaminopropanoate as a replacement for I-131 hippurate: concise communication.
abstract: A clinical comparison of Tc-99m N,N'-bis( mercaptoacetyl )-2,3- diaminopropanoate (Component A) (Tc-99m CO2-DADS-A) and I-131 hippurate was conducted in a series of five normal volunteers and 18 patients. Each subject was studied in one session with Tc-99m CO2-DADS-A and I-131-hippurate; digital and analog images were recorded for 30 min and after voiding. In the normal volunteers, digital images with Tc-99m CO2-DADS-A gave a kidney-to-background ratio at 3 min that was greater relative to I-131 hippurate, a leading-edge parenchymal transit time that was similar to I-131 hippurate, and a percent injected dose in the urine at 30 min that was slightly less than I-131 hippurate (p less than 0.05). In patients (serum creatinine 1.0 to 14.3 mg/dl), decreasing renal function impaired excretion of Tc-99m CO2-DADS-A more than that of I-131 hippurate (p less than 0.01). In analog images, Tc-99m CO2-DADS-A always gave superior spatial resolution. No evidence of hepatobiliary excretion was detected with either radiopharmaceutical. We conclude that Tc-99m CO2-DADS-A and similar compounds should be pursued as possible replacements for I-131 hippurate.
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives*; D003201:Computers; D003202:Computers, Analog; D006626:Hippurates / Q000652:urine; D006801:Humans; D007457:Iodine Radioisotopes; D007668:Kidney / Q000098:blood supply / Q000000981:diagnostic imaging*; D007674:Kidney Diseases / Q000000981:diagnostic imaging; D016030:Kidney Transplantation; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D013667:Technetium / Q000652:urine; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000652:urine
chemical_list: D006626:Hippurates; D007457:Iodine Radioisotopes; D015609:Organotechnetium Compounds; C034974:technetium Tc-99m N,N'-bis(mercaptoacetyl)-2,3-diaminopropanoate; D015091:beta-Alanine; D013667:Technetium; D000409:Alanine; C030514:hippuric acid