Renal function and mercury level in rats with mercuric chloride nephrotoxicity.
The levels of Hg++ in different subcellular compartments of rat kidney cortex were determined after a single subcutaneous injection of 203HgCl2, 4.7 mg/kg body weight. By 30 min after injection, cortical Hg++ level was 46.3 +/- 6.8 micrograms/g protein. A maximal cortical Hg++ value of 429 +/- 49 micrograms/g protein was reached 4 h after injection. Hg++ associated with the brush border membrane showed a progressive increase during the first 15 h after injection, but at each time interval was significantly less than cortical Hg++. The 45-hour values for cortex and brush border were equivalent. No evidence for the presence in plasma or kidney tissue of free Hg++ was obtained. Saline loading protected animals against the development of renal failure and resulted in significant lowering of cortical Hg++ levels without an effect on blood Hg++ concentration.
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D000818:Animals; D002712:Chlorides / Q000378:metabolism; D005260:Female; D007668:Kidney / Q000503:physiopathology; D007672:Kidney Cortex / Q000378:metabolism*; D008627:Mercuric Chloride; D008628:Mercury / Q000097:blood / Q000378:metabolism*; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology
D002712:Chlorides; D012965:Sodium Chloride; D008627:Mercuric Chloride; D008628:Mercury