c-myc Gene activation and chromosomal translocation.
Burkitt's lymphoma cells are characterized by the presence of specific chromosomal translocation bringing the immunoglobulin and the c-myc proto-oncogenes into the proximity of each other. Different translocations involve each of the three immunoglobulin loci but the breakpoint with respect to the c-myc gene is shown to be very variable. In t8/14 the breakpoint occurs upstream from the c-myc gene whilst in the variant lymphomas it occurs downstream from the gene. Possible ways in which the translocation affects the c-myc gene are discussed.
D000818:Animals; D001483:Base Sequence; D002051:Burkitt Lymphoma / Q000235:genetics; D002875:Chromosomes / Q000502:physiology*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D051379:Mice; D008957:Models, Genetic; D009101:Multiple Myeloma; D009857:Oncogenes; D014178:Translocation, Genetic
D007143:Immunoglobulin Heavy Chains