Cerebral infarction associated with lupus anticoagulants--preliminary report.
Hypercoagulability may contribute to stroke in young adults. Lupus anticoagulants (LA) were identified in six patients (4%) of 145 young adults with cerebral infarction. The clinical features of the 6 patients in this survey plus an additional patient from another institution with LA-associated stroke are presented. Four had systemic lupus erythematosus and 3 had idiopathic LA; all had mild thrombocytopenia. In 2 patients, no other conditions associated with stroke were discovered after thorough evaluation. Recurrent arterial thrombosis occurred in 4 of 7 patients during an average of two years of follow-up. Evidence suggests that inhibition of prostacyclin formation may occur with LA, promoting a prothrombotic state.
D000293:Adolescent; D000328:Adult; D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors* / Q000097:blood; D002544:Cerebral Infarction / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006429:Hemiplegia / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000503:physiopathology*; D008297:Male; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D012008:Recurrence; D012189:Retrospective Studies; D013921:Thrombocytopenia / Q000150:complications / Q000503:physiopathology; D013927:Thrombosis / Q000503:physiopathology
D001779:Blood Coagulation Factors; D016682:Lupus Coagulation Inhibitor