[Influence of PSK on the metabolism of FT-207].
The influence of PSK on the metabolism of FT-207 was studied in patients with gastric cancer. The 5-FU concentration in the blood was determined 15 min, 30 min, 1 hour and 3 hours after intravenous injection of FT-207, 400mg. The blood level of 5-FU remained constant in 86% of patients after administration of PSK for 7 days, but decreased in 14% of patients. After administration of PSK for 8 to 14 months, no change in the blood level of 5-FU was detected. These results suggest that PSK has no distinct influence on the activation of FT-207.
D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000097:blood; D006801:Humans; D011509:Proteoglycans / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000628:therapy; D005641:Tegafur / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D011509:Proteoglycans; D005641:Tegafur; C010770:polysaccharide-K; D005472:Fluorouracil