The anxiogenic action of FG 7142 in the social interaction test is reversed by chlordiazepoxide and Ro 15-1788 but not by CGS 8216.
The effects of FG 7142 were examined in the social interaction test, alone and in combination with chlordiazepoxide, Ro 15-1788 and CGS 8216. The anxiogenic action of FG 7142 (5 mg/kg) was reversed by chlordiazepoxide (5 mg/kg) and by Ro 15-1788 (10 mg/kg), but not by CGS 8216 (10 mg/kg). The profile of FG 7142 in this test and the pattern of its interactions with other compounds is similar to that of beta-CCE, but can be distinguished from that of Ro 15-1788 and CGS 8216. It is concluded that FG 7142, Ro 15-1788 and CGS 8216 may act via different sites to produce their anxiogenic effects.
D000818:Animals; D001007:Anxiety / Q000139:chemically induced*; D001570:Benzodiazepinones / Q000494:pharmacology*; D002243:Carbolines / Q000037:antagonists & inhibitors*; D002707:Chlordiazepoxide / Q000494:pharmacology*; D003292:Convulsants / Q000494:pharmacology*; D005442:Flumazenil; D006801:Humans; D007211:Indoles / Q000037:antagonists & inhibitors*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D012919:Social Behavior
D001570:Benzodiazepinones; D002243:Carbolines; D003292:Convulsants; D007211:Indoles; D011720:Pyrazoles; D005442:Flumazenil; C035874:FG 7142; D002707:Chlordiazepoxide; C033830:2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one