Bile duct adenocarcinoma with Leser-Trelat sign and pure red blood cell aplasia.
A case of adenocarcinoma of the bile duct complicating longstanding ulcerative colitis and associated with the rapid onset and growth of multiple seborrheic keratosis (Leser-Trelat sign) and pure red blood cell aplasia is described. This is the first report of a case of the coexistence of the Leser-Trelat sign and pure red blood cell aplasia in a patient with a malignancy. Both manifestations have been doubted as truly paraneoplastic manifestations because of their rarity in clinical medicine. Their co-existence in the present case would support their associaton with malignancy.
D000230:Adenocarcinoma / Q000150:complications*; D000368:Aged; D000741:Anemia, Aplastic / Q000209:etiology* / Q000473:pathology; D001650:Bile Duct Neoplasms / Q000150:complications*; D001853:Bone Marrow / Q000473:pathology; D003093:Colitis, Ulcerative / Q000150:complications; D012628:Dermatitis, Seborrheic / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007642:Keratosis / Q000209:etiology* / Q000473:pathology