Role of cell--cell interaction in normal and abnormal erythropoiesis.
A number of studies have demonstrated that certain immunocompetent cells play a role in the regulation of normal erythropoiesis. These regulatory cells (monocytes--macrophages, lymphocytes) modulate almost every phase of the erythropoietic process, and along with erythropoietin represent the major controlling force in erythropoiesis. Evidence indicate that pathological alterations of these cell-mediated activities can lead to clinical disturbances of red cell production such as is seen in patients with Diamond-Blackfan syndrome and aplastic anemia.
D000741:Anemia, Aplastic / Q000097:blood / Q000209:etiology* / Q000628:therapy; D000818:Animals; D001853:Bone Marrow / Q000276:immunology; D004920:Erythropoiesis; D004921:Erythropoietin / Q000502:physiology; D006680:HLA Antigens / Q000276:immunology; D006412:Hematopoietic Stem Cells / Q000166:cytology; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D009000:Monocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D006680:HLA Antigens; D004921:Erythropoietin