[Radiosensitive mutants of Drosophila. VI. The effect of ultraviolet rays and methylmethane sulfonate on the viability and incidence of chromosome aberrations in the somatic cells of mutant mus(2)201G1].
The mus(2)201G1 mutation determining high sensitivity to UV-rays and methyl methansulfonate (MMS) has been studied. The larvae of Drosophila of different age were treated with UV-rays and MMS. Lethality of organisms during the larvae and the pupa stages of the development, as well as the frequency of spontaneous and induced chromosome aberrations were registered. The mus(2)201G1 mutation was shown to determine high lethality of Drosophila during larvae and pupa stages as well as a high frequency of spontaneous and induced chromosome aberrations. The conclusion was made that chromosome aberrations are not the single reason for the death of the mutant flies after mutagenic treatment and that the function of the mus(2)201G1 gene is necessary for divided and undivided cells.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D004331:Drosophila melanogaster; D007814:Larva / Q000187:drug effects / Q000528:radiation effects; D008741:Methyl Methanesulfonate / Q000494:pharmacology*; D009154:Mutation; D011836:Radiation Tolerance; D014466:Ultraviolet Rays
D008741:Methyl Methanesulfonate
Izuchenie radiochuvstvitel'nykh mutantov drozofily. Soobshchenie VI. Vliianie ul'trafioletovykh lucheĭ i metilmetansul'fonata na vyzhivaemost' i chastotu khromosomnykh aberratsiĭ v somaticheskikh kletkakh mutanta mus(2)201G1.