[Demonstration of the effects on the corneal epithelium of a mucomimetic collyrium. Study using scanning microscopy].
Ocular surface drying was studied in rabbits using an experimental model of blinking interruption. This model produces a discontinuity in the pre-corneal tear film after a few minutes of exposure to air. Changes in superficial epithelial cell structure were studied using a scan microscope. A decrease of micro-folds and an increase in epithelial cell desquamation were observed. Prolonged exposure to air produced similar cellular lesions in deeper layers. The instillation of a single mucomimetic eye-drop containing chondroitin sulphate prevented total interruption of epithelial humidification, kept the epithelial surface intact and preserved normal cellular structure.
D000818:Animals; D002807:Chondroitin / Q000031:analogs & derivatives*; D002809:Chondroitin Sulfates / Q000008:administration & dosage / Q000627:therapeutic use*; D003315:Cornea / Q000187:drug effects* / Q000648:ultrastructure; D004195:Disease Models, Animal; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D009883:Ophthalmic Solutions; D011817:Rabbits; D014985:Xerophthalmia / Q000188:drug therapy* / Q000473:pathology
D009883:Ophthalmic Solutions; D002807:Chondroitin; D002809:Chondroitin Sulfates
Mise en évidence des effets sur l'épithélium cornéen d'un collyre mucomimétique. Etude en microscopie à balayage.