H2 gene control and biological activities of a T-cell mitogen derived from Mycoplasma arthritidis: a review.
Mycoplasma arthritidis generates a soluble, non-dialysable, polyclonal mitogen which is active for murine and human T lymphocytes in the presence of an adherent, radio-resistant, Ia-bearing accessory cell population. Genetic analysis has established that the I-E sub-region of the murine H2 gene complex controls responses to the mitogen and that this control is exercised at the level of the Ia-bearing accessory cell. Lymphocyte proliferation, induction of cytotoxic lymphocytes, and interferon induction are all under Ir gene control and appear to be dependent upon binding of the mitogen to a specific Ia antigen present on a subset of splenic cells. This mycoplasma mitogen provides a new model system to define the mechanisms of Ir gene control of lymphocyte activation.
D000818:Animals; D005802:Genes, MHC Class II / Q000187:drug effects; D006183:H-2 Antigens / Q000235:genetics*; D000949:Histocompatibility Antigens Class II; D007371:Interferon-gamma / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008262:Macrophage Activation; D051379:Mice; D008815:Mice, Inbred Strains; D008934:Mitogens / Q000378:metabolism / Q000494:pharmacology*; D009174:Mycoplasma / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D013601:T-Lymphocytes / Q000276:immunology*
D006183:H-2 Antigens; D000949:Histocompatibility Antigens Class II; D008934:Mitogens; D007371:Interferon-gamma