title: The therapeutic effect of ascorbic acid and EDTA in manic-depressive psychosis: double-blind comparisons with standard treatments.
abstract: The effect of ascorbic acid and ethylene diamine tetra acetic acid (EDTA) in the treatment of manic-depressive psychosis was compared, using double-blind procedures, with recognized treatment regimes. There was no significant difference between the response of depressed patients to amitriptyline or ascorbic acid and EDTA. Manic patients responded significantly better to lithium than to ascorbic acid and EDTA. These results are in keeping with the suggestion that vanadium may be of aetiological importance in depressive psychosis, but do not support such a suggestion for mania.
mesh_terms: D000639:Amitriptyline / Q000627:therapeutic use; D001205:Ascorbic Acid / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D004311:Double-Blind Method; D004492:Edetic Acid / Q000627:therapeutic use*; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D016651:Lithium Carbonate; D011569:Psychiatric Status Rating Scales; D014639:Vanadium / Q000037:antagonists & inhibitors
chemical_list: D014639:Vanadium; D000639:Amitriptyline; D016651:Lithium Carbonate; D008094:Lithium; D004492:Edetic Acid; D001205:Ascorbic Acid