Plasma lipids and lipoproteins pattern in beta-thalassemia major.
We studied serum lipids and lipoproteins in 20 patients with beta-thalassemia major, under high transfusion programme and regular chelation therapy, and in 20 control subjects. Total cholesterol, HDL-cholesterol, HDL2-and HDL3-cholesterol, apolipoprotein A and B levels were significantly lower in patients with Cooley's anemia, whereas free cholesterol, triglycerides and the HDL-/HDL3-cholesterol ratio did not differ in the two groups. We think that liver damage plays an important role in determining the altered lipoprotein pattern in beta-thalassemia major. However, other factors may contribute to cause such lipid changes.
D000293:Adolescent; D001053:Apolipoproteins / Q000097:blood; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D002648:Child; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008107:Liver Diseases / Q000209:etiology; D008297:Male; D013789:Thalassemia / Q000097:blood* / Q000150:complications / Q000503:physiopathology
D001053:Apolipoproteins; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D008076:Cholesterol, HDL; D008055:Lipids; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D002784:Cholesterol