Musculoskeletal manifestations of Paget's disease of bone.
A review of 290 patients with Paget's disease of bone revealed 83% had one or more rheumatic syndromes. The most common finding was back pain (37%), most often related to an independent osteoarthritic process or Paget's disease precipitating or complicating spinal osteoarthritis. Paget's disease as a sole source of back pain was distinctly uncommon (2%). Osteoarthritis related to Paget's disease was present in the hip (30%) and knee (11%). Paget's disease in spondylitis was present in 4 patients and in ankylosing hyperostosis in 4 patients. The latter group had very active Paget's disease. Rheumatoid arthritis (1%), hyperuricemia (20%), and gout (4%) did not appear increased in this group.
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000150:complications; D001416:Back Pain / Q000150:complications; D005260:Female; D006073:Gout / Q000150:complications; D006621:Hip Joint; D006801:Humans; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000150:complications*; D010003:Osteoarthritis / Q000150:complications*; D012886:Skull / Q000503:physiopathology; D013122:Spinal Diseases / Q000150:complications; D013166:Spondylitis / Q000150:complications; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid; D000469:Alkaline Phosphatase