The so-called intravascular bronchioloalveolar tumour of lung (low grade sclerosing angiosarcoma): presentation with extrapulmonary deposits.
Two further cases of the so-called intravascular bronchioloalveolar tumour of lung are reported. Electron microscopic demonstration of Weibel-Palade bodies and immunocytochemical demonstration of factor VIII in the cytoplasm of the tumour cells indicate the vascular nature of these lesions. One patient presented with an enlarged liver and the tumour was found to be involving the liver and parietal pleura as well as the lung. The characteristic micropolypoid structure was not seen in the pleural or hepatic deposits and it is evident that this feature is a consequence of the alveolar architecture of the lung and is not an inherent property of the tumour.
D005169:Factor VIII / Q000032:analysis; D005260:Female; D006394:Hemangiosarcoma / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007124:Immunoenzyme Techniques; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary / Q000648:ultrastructure; D008175:Lung Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010997:Pleural Neoplasms / Q000473:pathology / Q000556:secondary / Q000648:ultrastructure; D011650:Pulmonary Alveoli / Q000473:pathology* / Q000648:ultrastructure
D005169:Factor VIII