title: [Long-term treatment with coumarin preparations in advanced age].
abstract: It is reported on the occurrence of haemorrhagic complications at old age in patients treated with coumarin. Altogether 352 patients were examined, 96 of them were older than 70 years. A small part of the patients, above all men with obliterating vascular occlusions of the lower extremity were additionally given also thrombocyte aggregation inhibitors. The effective prothrombin level was nearly the same in the two, groups, i.e. in the patients younger and older than 70 years. There was no difference in frequency and severity of the haemorrhages with the exception of macrohaematuria which, however, appeared above all in the younger age group and in women older than 70 years. Under observation of the indications and with a regular control a long-term treatment with coumarin preparations can performed without any particular risk also at old age.
mesh_terms: D000074:Acenocoumarol / Q000009:adverse effects / Q000627:therapeutic use*; D000368:Aged; D001162:Arteriosclerosis Obliterans / Q000188:drug therapy*; D002543:Cerebral Hemorrhage / Q000139:chemically induced; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced; D006801:Humans; D008134:Long-Term Care; D008297:Male; D011516:Prothrombin / Q000378:metabolism; D011655:Pulmonary Embolism / Q000188:drug therapy; D013923:Thromboembolism / Q000188:drug therapy*; D013924:Thrombophlebitis / Q000188:drug therapy*
chemical_list: D011516:Prothrombin; D000074:Acenocoumarol
vernacular_title: Langzeitbehandlung mit Kumarinpräparaten im hohen Lebensalter.