title: In vitro effects of skin lipid extracts on skin bacteria in relation to age and acne changes.
abstract: Skin lipid extracts of 185 persons of different age were tested in vitro against single representatives of skin bacteria: Staphylococcus aureus, S. epidermidis, Propionibacterium acnes, P. granulosum and Corynebacterium sp. in order to find differences in their inhibitory effects. Percentages of the extracts inhibiting the first 4 bacteria were nearly the same (about 20%) while corynebacteria were inhibited by only 3 extracts. Extracts showing these properties were isolated mainly from adolescents with acne changes, young adults, about 20 yr old, and from children 8--10 yr old, but not from elderly people. The age-related differences in growth inhibition may be related to known differences in relative composition of the sebum constituents according to age. Forty-two extracts of acne patients and healthy adults and adolescents showed an inverse effect in vitro: they enhanced bacterial growth. Growth enhancement was demonstrated only for P. granulosum.
mesh_terms: D000152:Acne Vulgaris / Q000503:physiopathology*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001419:Bacteria / Q000187:drug effects*; D002648:Child; D003352:Corynebacterium / Q000187:drug effects; D005260:Female; D006131:Growth Inhibitors / Q000032:analysis*; D006801:Humans; D066298:In Vitro Techniques; D008055:Lipids / Q000494:pharmacology*; D008297:Male; D011425:Propionibacterium acnes / Q000187:drug effects; D012629:Sebum / Q000032:analysis; D012867:Skin / Q000032:analysis* / Q000503:physiopathology; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D006131:Growth Inhibitors; D008055:Lipids