Remarks on the structure-activity relationship of silver sulfanilamides.
The biological activity of a series of 10 silver sulfanilamides is studied in relation to the physical parameters pK alpha, log K, and the aqueous solubility. None of the parameters demonstrate a simple relationship with the activity. A discussion of the significance of log K and the solubility in relation to the activity is given.
D009824:Ointments / Q000032:analysis; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012834:Silver; D013329:Structure-Activity Relationship; D013424:Sulfanilamides / Q000494:pharmacology*
D009824:Ointments; D013424:Sulfanilamides; D012834:Silver