title: Distribution of sodium valproate and GABA metabolism in CNS of the rat.
abstract: The distribution of VPA has been investigated in several brain areas of the rat, and GABA increases were measured. A biphasic exponential decay was observed for VPA; the slowest decrease was noted in the olfactory bulbs and in the hypothalamus where GAD and GABA-T activities were the highest. The data may be correlated with the prolonged effect of VPA in these areas.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014635:Valproic Acid / Q000097:blood / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000097:blood / Q000378:metabolism*
chemical_list: D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid