title: Detection of alpha 1 and alpha 2 heavy-chain constant-region genes in common variable hypogammaglobulinaemia patients with undetectable IgA.
abstract: Five patients with common variable hypogammaglobulinaemia with undetectable levels of IgA in serum and saliva were investigated for immunoglobulin structural gene defects. All five patients carried in their genome alpha 1 and alpha 2 genes as detected in Southern blotting analysis by means of a cloned C alpha gene probe.
mesh_terms: D000361:Agammaglobulinemia / Q000235:genetics / Q000276:immunology*; D004247:DNA / Q000032:analysis; D005796:Genes; D006801:Humans; D007070:Immunoglobulin A; D007127:Immunoglobulin Constant Regions / Q000235:genetics*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007137:Immunoglobulin alpha-Chains / Q000235:genetics*; D007136:Immunoglobulins / Q000235:genetics*
chemical_list: D007070:Immunoglobulin A; D007127:Immunoglobulin Constant Regions; D007143:Immunoglobulin Heavy Chains; D007137:Immunoglobulin alpha-Chains; D007136:Immunoglobulins; D004247:DNA