Effects of different bacterial endotoxins on the drinking behaviour of the rat.
Endotoxins of Pasteurella multocida, Pseudomonas aeruginosa, Neisseria gonorrhoeae, and Shigella sonnei, when given in a single intravenous injection in the rat, showed antidipsogenic effects on drinking behaviour stimulated by 48 h water deprivation, or by intracerebroventricular injection of carbachol (250 ng). In water deprived rats, the antidipsogenic effect was dose related. When drinking was induced by carbachol, endotoxins showed a very long-lasting inhibition. The effect was neither a consequence of behavioural alterations, nor due endotoxin peripheral vasodilatating properties.
D000818:Animals; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors; D001241:Aspirin / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D004327:Drinking Behavior / Q000187:drug effects*; D004731:Endotoxins / Q000494:pharmacology*; D008297:Male; D009344:Neisseria gonorrhoeae; D010325:Pasteurella; D011550:Pseudomonas aeruginosa; D051381:Rats; D011919:Rats, Inbred Strains; D012764:Shigella sonnei; D012965:Sodium Chloride / Q000494:pharmacology
D001095:Arachidonic Acids; D004731:Endotoxins; D012965:Sodium Chloride; D002217:Carbachol; D001241:Aspirin