Does trypsin extract soluble antigen meet the criteria of immunogenicity without allergenicity?
We were unable to confirm the finding of Crowle that TESA possesses the attribute of immunogenicity and absence of allergenicity which are desired in a non-living antituberculosis vaccine. This disagreement could be a function of the particular lot of TESA examined and/or differences in the animal test systems used for the assay of protective potency. The relative contribution of these two possibilities could be determined by the simultaneous assay of a potent TESA product in different laboratories using different animal models.
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D008297:Male; D009163:Mycobacterium bovis; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D014357:Trypsin; D014376:Tuberculosis / Q000517:prevention & control*; D014612:Vaccines / Q000276:immunology*
D000942:Antigens, Bacterial; D014612:Vaccines; D014357:Trypsin