Research on ibuprofen for sepsis and respiratory failure.
According to an experimental study in 26 dogs, ibuprofen reversed the hypotension, increased the cardiac index, prevented the acidosis associated with endotoxic shock, and apparently improved survival. In animals given endotoxin followed by ibuprofen, an initial decrease in systemic blood pressure subsequently recovered to 150.2 +/- 4.1 mm Hg in 120 minutes (p less than 0.001). Cardiac index increased in ibuprofen-treated animals (2.3 +/- 0.28 1/m2 per minute), compared with animals given endotoxin alone (1.0 +/- 0.09 1/m2 per minute) by termination of the experiment. In addition, although arterial pH decreased to 7.18 +/- 0.03 by 120 minutes in animals given only endotoxin, final pH was 7.36 +/- 0.01 in the ibuprofen-treated group.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D006863:Hydrogen-Ion Concentration; D007052:Ibuprofen / Q000494:pharmacology / Q000627:therapeutic use*; D008084:Lipoxygenase / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism; D012128:Respiratory Distress Syndrome / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D012772:Shock, Septic / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism
D001095:Arachidonic Acids; D011453:Prostaglandins; D016718:Arachidonic Acid; D008084:Lipoxygenase; D007052:Ibuprofen