Effect of antacid on the bioavailabiity of lithium carbonate.
The effect of an antacid on the bioavailability of lithium carbonate was determined in six healthy men in a crossover study. The volunteers were given single 300-mg doses of lithium carbonate alone and with 30 ml of an antacid containing aluminum and magnesium hydroxides with simethicone. Blood samples were collected at various times for 0-24 hours after each dose. The plasma samples were analyzed for lithium using a spectrophotometer, and bioavailability variables were calculated from plasma lithium concentration-time curves. There were no significant differences in peak plasma lithium concentration, time to peak concentration, area under the concentration-time curve from 0 to 24 hours, first-order absorption rate constant, and first-order elimination rate constant between the two treatments. Concurrent administration of antacids and lithium carbonate should not affect lithium blood concentrations.
D000328:Adult; D000863:Antacids / Q000494:pharmacology*; D001682:Biological Availability / Q000187:drug effects; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D008094:Lithium / Q000097:blood / Q000378:metabolism*; D016651:Lithium Carbonate; D008297:Male; D013997:Time Factors
D000863:Antacids; D016651:Lithium Carbonate; D008094:Lithium