title: Changes in the molecular sieve of glomerular basement membrane in rats with aminonucleoside nephrosis.
abstract: Isolated and purified glomerular basement membranes (GBM) of normal and aminonucleoside (PAN) nephrosis rats were observed by electron microscopy after negative staining. Although GBM of normal rats appeared as a molecular sieve with uniform pores, GBM of nephrotic rats showed enlargement and elongation of the pores. For an average of fifty pores, the long dimension was 40.4+/-10.7 A and the short dimension 13.8+/-3.6 A in nephrosis whereas the long dimension was 12.3+/-2.5 A and the short dimension 8.4+/-1.0 A in normal rats. Changes in the pores in GBM were thought to result in increased permeability of serum protein and hence proteinuria.
mesh_terms: D000818:Animals; D001485:Basement Membrane / Q000648:ultrastructure; D007678:Kidney Glomerulus / Q000648:ultrastructure*; D008297:Male; D009404:Nephrotic Syndrome / Q000139:chemically induced / Q000473:pathology*; D011692:Puromycin Aminonucleoside; D051381:Rats
chemical_list: D011692:Puromycin Aminonucleoside