Sodium ethylmercurithiosalicylate (Merthiolate) inhibition of antigen-antibody interactions in radioimmunoassay systems.
Sodium ethylmercurithiosalicylate (Merthiolate), used for preservation of buffer solutions, was found to inhibit the antigen-antibody binding reactions in radioimmunoassay systems in a noncompetitive manner. This effect is attributable to the mercury ion per se.
D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D004151:Dipeptides / Q000097:blood; D005035:Ethylmercury Compounds / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000097:blood; D010879:Piperazines / Q000097:blood; D011817:Rabbits; D011863:Radioimmunoassay; D013849:Thimerosal / Q000494:pharmacology*; D013973:Thyrotropin-Releasing Hormone / Q000097:blood
D004151:Dipeptides; D005035:Ethylmercury Compounds; D010456:Peptides, Cyclic; D010879:Piperazines; C035699:histidylproline; D013849:Thimerosal; D013973:Thyrotropin-Releasing Hormone; C015924:histidyl-proline diketopiperazine