title: IgA deficiency during aurothioglucose treatment. A case report.
abstract: A 43-year-old woman with seronegative rheumatoid arthritis developed a selective IgA deficiency during aurothioglucose treatment. No antibodies against IgA were detectable in the serum; normal numbers of IgA, IgG and IgM positive cells were demonstrated by immunofluorescence studies on a biopsy specimen from the small intestine. These data would suggest a defect in IgA secretion rather than in production by plasma cells.
mesh_terms: D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology; D006051:Aurothioglucose / Q000009:adverse effects*; D004406:Dysgammaglobulinemia / Q000139:chemically induced*; D005260:Female; D006046:Gold / Q000009:adverse effects*; D006801:Humans; D017098:IgA Deficiency; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D006051:Aurothioglucose; D006046:Gold