Potentiation of an IgE-like response to Bordetella bronchiseptica in pigs following Ascaris suum infection.
Ascaris suum-infected and uninfected pigs were vaccinated with Bordetella bronchiseptica bacterin at 8 and 28 days of age. Only the infected pigs gave Type I cutaneous hypersensitivity to the bacterin when tested at 80 days of age. Only the native sera of infected pigs caused passive cutaneous anaphylaxis 24 h after inoculation into guinea pigs. Heating the sera at 56 degrees C for 4 h abolished this property. Mice infected with A. suum for 34 days did not react to the bacterin. An A. suum infection induces an IgE-like response to B. bronchiseptica in pigs that is not explained by cross-reactive antigens. This finding may have practical implications for the immunization against atrophic rhinitis of swine.
D000818:Animals; D001196:Ascariasis / Q000276:immunology / Q000662:veterinary*; D001428:Bacterial Vaccines / Q000276:immunology*; D001884:Bordetella / Q000276:immunology*; D003429:Cross Reactions; D006168:Guinea Pigs; D005779:Immunodiffusion / Q000662:veterinary; D007073:Immunoglobulin E / Q000096:biosynthesis*; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis; D012882:Skin Tests / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000276:immunology*
D001428:Bacterial Vaccines; D007073:Immunoglobulin E