title: Effects of acute hypobaric hypoxia on acid-base status of fowl blood.
abstract: Arterial blood Po/, Pco2, lactate levels and Cl- ion concentration as well as pH were measured on the time course in chickens (Gallus domesticus) as they settled in normoxic conditions and during exposure to acute hypobaric hypoxia (Pb = 450 Torr). Hypoxia provoked at first a CO2 increased output from blood and a brief stage of deep metabolic acidosis during which lactate levels suddenly increased. This acidosis was then compensated producing a return to the initial pH and a decrease in [HCO3-] + [CO3(2-)] after 60 min. Subsequently respiratory alkalosis associated with an increase in [HCO-3] + [CO3(2-)], a decrease in cl- ion concentration and a small decrease in lactate levels were observed. Prolonged exposure to hypoxia (16 h) resulted in a new return to the initial pH, a decrease in concentration of [HCO3-] + [CO3(2-)] and a high lactate level. The hematocrit value, the Hb concentration, and the plasma Na+, K+, Ca++ and Mg++ ion concentration did not change significantly.
mesh_terms: D000137:Acid-Base Imbalance / Q000097:blood*; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D002412:Cations / Q000097:blood; D002645:Chickens / Q000097:blood*; D002712:Chlorides / Q000097:blood; D006863:Hydrogen-Ion Concentration; D000860:Hypoxia / Q000097:blood*; D007773:Lactates / Q000097:blood; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure
chemical_list: D002412:Cations; D002712:Chlorides; D007773:Lactates; D002245:Carbon Dioxide; D010100:Oxygen