title: Comparison of plasma clearances of polyfructosan and 51Cr-EDTA in children.
abstract: Plasma clearances of polyfructosan and 51Cr-EDTA were determined in 38 children with renal diseases and in five healthy children in order to compare the values for the glomerular filtration rate (GFR) obtained by single injection procedures. Both one-compartment (Cr-EDTA-1) and two-compartment (Cr-EDTA-2) analyses were made of the isotope decay curve. The children were divided into two age groups: (a) 24 children below 6 years, and (b) 19 children between 8 and 16 years of age. In both groups Cr-EDTA-1 GFR and Cr-EDTA-2 GFR correlated significantly with polyfructosan GFR. The correlation coefficients, however, were somewhat lower in the younger (r = 0.74, r = 0.73) than in the older children (r = 0.91, r = 0.93). There were no significant differences between simultaneously obtained polyfructosan GFR and Cr-EDTA-2 GFR based on paired observations while Cr-EDTA-1 GFR was somewhat higher (16%) than the simultaneously obtained polyfructosan GFR. We conclude that estimates of GFR from polyfructosan and Cr-EDTA clearances based on two compartment analyses and single injection procedures are interchangeable.
mesh_terms: D000293:Adolescent; D002648:Child; D004492:Edetic Acid / Q000008:administration & dosage / Q000097:blood*; D005630:Fructans / Q000008:administration & dosage / Q000097:blood*; D005919:Glomerular Filtration Rate; D006801:Humans; D007275:Injections, Intravenous; D007674:Kidney Diseases / Q000097:blood*; D011134:Polysaccharides / Q000097:blood*
chemical_list: D005630:Fructans; D011134:Polysaccharides; C002938:polyfructosan; D004492:Edetic Acid