Effects of preservatives, steroids, and ethylenediaminetetraacetate on the antimicrobial activity of sulfacetamide.
The effect of EDTA (ethylenediaminetetraacetate), steroids, and preservatives on the antimicrobial activity of 10% sodium sulfacetamide solutions was evaluated in this study by kill rate and minimum inhibitory concentration (MIC) using five representative microorganisms. The results indicate that thimerosal-preserved sulfacetamide solutions containing EDTA are more effective against Pseudomonas aeruginosa, Serratia marcescens, Staphylococcus epidermidis, and Candida albicans than similar paraben-preserved solutions. Furthermore, the addition of EDTA improves the kill rate, but not the MIC, for the Pseudomonas, Serratia, and Candida species regardless of the preservative. The combination of a steroid with sulfacetamide does not affect its antimicrobial activity.
D000891:Anti-Infective Agents, Local; D001419:Bacteria / Q000187:drug effects; D004347:Drug Interactions; D004492:Edetic Acid / Q000494:pharmacology*; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D009883:Ophthalmic Solutions; D010592:Pharmaceutic Aids / Q000494:pharmacology*; D011310:Preservatives, Pharmaceutical / Q000494:pharmacology*; D013256:Steroids / Q000494:pharmacology*; D013409:Sulfacetamide / Q000032:analysis / Q000494:pharmacology*
D000891:Anti-Infective Agents, Local; D009883:Ophthalmic Solutions; D010592:Pharmaceutic Aids; D011310:Preservatives, Pharmaceutical; D013256:Steroids; D013409:Sulfacetamide; D004492:Edetic Acid