Reversible tubular proteinuria associated with hyperglycemic ketoacidosis in type 1 diabetes mellitus.
Urinary protein excretion has been investigated in 14 children with hyperglycemic ketoacidosis secondary to diabetes mellitus. In 9 patients hyperglycemic ketoacidosis was the first manifestation of their disease and 5 patients were known diabetics and accidentally developed hyperglycemic ketoacidosis. A control group consisted of 15 diabetic children aged 7-16 years with good metabolic control. Duration of the disease ranged from 1 month to 9 years. A second group of controls consisted of 24 healty children aged 10-16 years. Urinary protein fractions were separated by sodium dodecyl sulphate polyacrylamide gel electrophoresis. Tubular proteinuria was found in all diabetic patients during hyperglycemic ketoacidosis and disappeared in all cases within 4 weeks of establishing satisfactory diabetic control. The pathological basis and effect of transient tubulointerstitial insufficiency as indicated by transient tubular proteinuria is discussed.
D001798:Blood Proteins / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D016883:Diabetic Ketoacidosis / Q000209:etiology* / Q000652:urine; D003928:Diabetic Nephropathies / Q000150:complications*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D008297:Male; D008970:Molecular Weight; D011506:Proteins / Q000032:analysis; D011507:Proteinuria / Q000150:complications*
D001798:Blood Proteins; D011506:Proteins