A general characteristic of tumor mitochondria: leakage of endogenous Mg2+ on incubation with uncoupler and resultant reduction of uncoupler-stimulated ATPase activity.
D019297:2,4-Dinitrophenol; D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002460:Cell Line; D004140:Dinitrophenols / Q000494:pharmacology*; D008274:Magnesium / Q000378:metabolism*; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D008813:Mice, Inbred ICR; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology; D009374:Neoplasms, Experimental / Q000201:enzymology*; D014475:Uncoupling Agents / Q000494:pharmacology*
D004140:Dinitrophenols; D014475:Uncoupling Agents; D000251:Adenosine Triphosphatases; D008274:Magnesium; D019297:2,4-Dinitrophenol