Protective effect of FR35447 on experimental cerebral infarction.
The protective effect of 2-(5-chloro-2-phenoxyanilino)-2-imidazoline [FR35447] on cerebral infarction was examined in animal models. FR35447 in p.o. doses of 1 mg/kg or more caused a marked reduction of arachidonate-induced cerebral infarction in rats. Since FR35447 (10(-6) M) inhibited platelet aggregation induced by adrenaline plus the divalent cation ionophore A23187, as did yohimbine (10(-6) M), the protective effect of FR35447 is presumed to be due to its blocking activity on the alpha 2 adrenoceptors of platelets. However, additional mechanisms appear to participate in the protective effect of FR35447 on cerebral infarction. A ten-day treatment with FR35447 in p.o. doses of 1 to 10 mg/kg/day decreased serum lipid peroxide levels in vitamin E deficient rats, suggesting that FR35447 may have free radical scavenging activity. Moreover, FR35447 (greater than or equal to 10(-5) M) increased red cell deformability. These effects of FR35447 suggest that it may be useful in preventing or treating cerebral infarction.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000633:toxicity; D000001:Calcimycin / Q000494:pharmacology; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D002544:Cerebral Infarction / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D004837:Epinephrine / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology; D004907:Erythrocyte Deformability / Q000187:drug effects; D007093:Imidazoles / Q000627:therapeutic use*; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011224:Prazosin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014811:Vitamin E Deficiency / Q000097:blood; D015016:Yohimbine / Q000494:pharmacology
D001095:Arachidonic Acids; D002317:Cardiovascular Agents; D007093:Imidazoles; D008054:Lipid Peroxides; D016718:Arachidonic Acid; D015016:Yohimbine; D000001:Calcimycin; C044312:2-(5-chloro-2-phenoxyanilino)-2-imidazoline; D011464:Epoprostenol; D011224:Prazosin; D004837:Epinephrine