[Effect of stenopril on the oxidative phosphorylation processes in rat mitochondria].
The author examined the influence of the preparation stenopryl on the processes of oxidative prosphorilation in the liver and cerebral mitochondria of a rat in view of clarifying some aspects of its pharmacobiochemical mechanism. The results from the experiments in vitro revealed that stenopryl inhibited the processes of oxidative phosphorilation in comparatively high concentrations. The lower concentrations of the preparation did not induce changes. Stenopryl used in vitro, raised ATP-ase activity in liver mitochondria. The data on the experiments in vivo with a dose of 20 mg/kg of stenopryl showed that the preparation did not affect the oxidative processes, when two substrates of oxidation were used, but inhibited phosphorilation when sodium succinate was used. ATP-ase activity during treatment in vivo was not altered.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000201:enzymology; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000201:enzymology; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010627:Phenethylamines / Q000494:pharmacology*; D051381:Rats; D014665:Vasodilator Agents / Q000494:pharmacology*
D010627:Phenethylamines; D014665:Vasodilator Agents; C026894:stenopril; D000251:Adenosine Triphosphatases
Vliianie na stenopril vŭrkhu protsesite na okislitelno fosforilirane na mitokhondrii ot plŭkh.