Treatment of anorectal gonorrhea infections in men.
The charts of 606 men with anorectal gonorrhea infections treated using the current Public Health Service recommendations were reviewed. There were 3.3% failures in the group treated with penicillin--14.4% in those treated with tetracycline hydrochloride, 14.8% in the ampicillin trihydrate group, and none among those treated with spectinomycin hydrochloride. The intramuscular (IM) injection of penicillin G procaine, 4.8 million units, with 1 g of probenicid given orally is the treatment of choice for anorectal gonorrhea. An IM injection of 2 g of spectinomycin hydrochloride was effective but should be reserved for patients allergic to penicillin and for penicillin treatment failures.
D000284:Administration, Oral; D001004:Anus Diseases / Q000188:drug therapy*; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D010402:Penicillin G Procaine / Q000008:administration & dosage; D011339:Probenecid / Q000008:administration & dosage; D012002:Rectal Diseases / Q000188:drug therapy*; D012737:Sex Factors; D000198:Spectinomycin / Q000008:administration & dosage
D010402:Penicillin G Procaine; D000198:Spectinomycin; D011339:Probenecid