Effect of guanidinoethane sulfonate on taurine uptake by rat retina.
Guanidinoethane sulfonate (GES) markedly decreased 3H-taurine accumulated in the retina by the high-affinity uptake process. The effect of GES was dose-dependent. Analysis of the kinetics of GES effect revealed that it is a competitive inhibitor. The uptake of taurine by GES was less affected in rat cerebral cortex slices, where the inhibition by 1 mM GES was only 28%. Taurine accumulation by tissues of rats treated with GES (0.1% and 1% in the drinking water) was found to be particularly decreased in the retina, although accumulation by heart and liver was also affected by the higher dose. Taurine uptake by cerebellum and cerebral cortex slices was unaffected by GES. Treatment of rats with GES is known to produce an alteration in the structure and function of the retina, but apparently not in other organs. We discuss whether the marked effect of GES on taurine transport by the retina is related to the deleterious effect of the inhibitor in this organ.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000187:drug effects* / Q000378:metabolism; D013654:Taurine / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology; D015091:beta-Alanine / Q000494:pharmacology
D015091:beta-Alanine; D013654:Taurine; C009558:taurocyamine