title: Effects of amiloride on calcium uptake by myocytes isolated from adult rat hearts.
abstract: Amiloride at high concentrations inhibits the uptake of Ca by rat heart myocytes containing elevated levels of intracellular Na and retards the development of Ca-dependent hypercontracture in these cells. In contrast, amiloride enhances the net uptake of Ca in Ca-tolerant myocytes containing normal levels of Na. The results suggest that amiloride may inhibit Na-Ca exchange across the sarcolemma of cardiac myocytes.
mesh_terms: D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004533:Egtazic Acid / Q000494:pharmacology; D009206:Myocardium / Q000166:cytology* / Q000378:metabolism; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D012508:Sarcolemma / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D013997:Time Factors
chemical_list: D011719:Pyrazines; D004533:Egtazic Acid; D000584:Amiloride; D012964:Sodium; D002118:Calcium