title: Immunity against infection with Trypanosoma cruzi in mice correlates with presence of antibodies against three trypomastigote polypeptides.
abstract: Repeated immunizations of CF1 mice with irradiated noninfectious Trypanosoma cruzi trypomastigotes resulted in partial protection against infection with live parasites. It also induced a limited number of antibody species that were reactive in Western blots with trypomastigote but not with epimastigote or amastigote polypeptides. These antibody species were strongly reactive with a 100,000-dalton polypeptide and much less reactive with at least two polypeptides greater than 200,000 daltons. Immunization with epimastigotes induced antibodies against a 57,000-dalton epimastigote-specific polypeptide but did not induce protective immunity.
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology; D000953:Antigens, Protozoan / Q000276:immunology*; D002478:Cells, Cultured; D014355:Chagas Disease / Q000276:immunology*; D007114:Immunization; D051379:Mice; D014349:Trypanosoma cruzi / Q000276:immunology*
chemical_list: D000906:Antibodies; D000953:Antigens, Protozoan