Computer simulation of metal ion equilibria in biofluids. IV. Plutonium speciation in human blood plasma and chelation therapy using polyaminopolycarboxylic acids.
An investigation by computer simulation into the nature of Pu(IV) binding to low-molecular ligands in human blood plasma is described. Particular consideration is given to the interactions of various chelating agents which have been or might be used for treating plutonium intoxication. Formation constants of EDTA and DTPA with Cu(II), Mg(II), Mn(II), Zn(II), and Cd(II) have been measured under biologic conditions of temperature and background electrolyte. The relative ability of these and other chelating agents to cause excretion of plutonium and the concomitant loss of certain essential trace metals has thus been assessed.
D002614:Chelating Agents / Q000627:therapeutic use; D003201:Computers; D004492:Edetic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D006801:Humans; D008954:Models, Biological; D004369:Pentetic Acid / Q000031:analogs & derivatives / Q000627:therapeutic use; D011005:Plutonium / Q000097:blood* / Q000633:toxicity
D002614:Chelating Agents; C005390:CDTA; D011005:Plutonium; C031239:puchel; D004369:Pentetic Acid; D004492:Edetic Acid