[Effect of vitamin A excess and T-2 toxin on the enzyme system activities of the second phase of xenobiotic metabolism in the rat liver].
Oral administration of retinyl palmitate to young Wistar rats during 7 days (70,000 IU of vitamin A per 100 g of body weight daily) caused a decrease in the liver UDP-glucuronosyl transferase and glutathione transferase activities and a significant decrease in the liver glutathione-SH content. A single administration of T-2 toxin (3 mg per kg of body weight) to rats after the treatment with high doses of vitamin A was accompanied by an increase in T-2 toxicity. The rat mortality was doubled and the decrease in UDP-glucuronosyl transferase and glutathione transferase activities was more distinct as compared with the rats treated with T-2 toxin only. Vitamin A excess appears to decrease the phase II drug-metabolizing enzyme activities and glutathione-SH content in rat liver tissue. Excess of vitamin A may be responsible for an increase of T-2 toxicity in rats.
D000818:Animals; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism*; D005982:Glutathione Transferase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012717:Sesquiterpenes / Q000633:toxicity*; D013605:T-2 Toxin / Q000633:toxicity*; D014801:Vitamin A / Q000008:administration & dosage / Q000633:toxicity*
D012717:Sesquiterpenes; D014801:Vitamin A; D005954:Glucosephosphate Dehydrogenase; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase; D013605:T-2 Toxin
Vliianie izbytka vitamina A i T-2 toksina na aktivnost' fermentnykh sistem vtoroĭ fazy metabolizma ksenobiotikov v pecheni krys.