[Morphologic characteristics of locus coeruleus neurons after selective chemical damage to the catecholaminergic system of the brain].
The initial part of the noradrenergic cerebral system--the locus caeruleus neurons--has been studied light and electron microscopically at various time after injection of 6- hydrodopamine (6-OHDA), a substance possessing a selective neurotoxic effect on the catecholaminergic mediatory system. Intracisternal injection of 6-OHDA (300 mcg) produces a number of reactive rearrangements in the neurons and large dendrites. Nevertheless, the death of the neural cells is not observed even by the 36th day.
D000818:Animals; D002395:Catecholamines / Q000502:physiology*; D006892:Hydroxydopamines / Q000494:pharmacology*; D008125:Locus Coeruleus / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009410:Nerve Degeneration; D009638:Norepinephrine / Q000378:metabolism; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains
D002395:Catecholamines; D006892:Hydroxydopamines; D016627:Oxidopamine; D009638:Norepinephrine
Morfologicheskaia kharakteristika neĭronov golubogo piatna pri selektivnom povrezhdenii katekholaminergicheskoi sistemy mozga.