Bioconversion of arachidonic acid to prostaglandins and related compounds in human myometrium and uterine cervix.
Arachidonic Acid metabolites in human myometrium and uterine cervix were studied using silicic acid column chromatography, thin layer chromatography, reversed phase partition chromatography and gas-liquid chromatography. Myometrium produced 6-ketoPGF1 alpha, PGF2 alpha, PGE2, thromboxane B2. Uterine cervix produced 6-ketoPGF1 alpha, PGF2 alpha, PGE2, thromboxane B2, and one hydroxyacid. There was no difference between the rate of conversion of prostaglandins in myometrium and cervix. But only cervix could convert arachidonic acid to hydroxyacid.
D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D002584:Cervix Uteri / Q000378:metabolism*; D002845:Chromatography; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D005260:Female; D006801:Humans; D006880:Hydroxy Acids / Q000378:metabolism; D009215:Myometrium / Q000378:metabolism*; D011453:Prostaglandins / Q000378:metabolism*; D013929:Thromboxane B2 / Q000378:metabolism
D001095:Arachidonic Acids; D006880:Hydroxy Acids; D011453:Prostaglandins; D016718:Arachidonic Acid; D013929:Thromboxane B2