The influence of 18 environmentally relevant polycyclic aromatic hydrocarbons and Clophen A50, as liver monooxygenase inducers, on the mutagenic activity of benz[a]anthracene in the Ames test.
In the presence of various liver S9 preparations induced by different polycyclic aromatic hydrocarbons, the weak carcinogen, benz[a]anthracene, exhibited mutagenic activities comparable to those of benzo[a]pyrene in the Ames test. A series of positive correlations were found between mutagenic activity and the hydroxylation products of benz[a]anthracene at the 3,4-, 5,6- and 8,9-positions, of which 5,6-position was the most pronounced one (p less than 0.01). Our results suggest that the observed mutagenic activity is due mainly to the generation of K-region epoxides.
D000818:Animals; D001551:Benz(a)Anthracenes / Q000633:toxicity*; D004785:Environmental Pollutants / Q000633:toxicity*; D004790:Enzyme Induction; D007700:Kinetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000096:biosynthesis*; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D011083:Polycyclic Compounds / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship; D013997:Time Factors
D001551:Benz(a)Anthracenes; D004785:Environmental Pollutants; D009153:Mutagens; D011083:Polycyclic Compounds; C025647:clophen A50; C030935:benz(a)anthracene; D011078:Polychlorinated Biphenyls; D006899:Mixed Function Oxygenases