Formation of 6-hydroxydopamine in caudate nucleus of the rat brain after a single large dose of methylamphetamine.
We now report that 6-hydroxydopamine (0.39 +/- 0.31 nanograms/mg of tissue at 2 hr) is formed in the rat caudate nucleus after a single injection of methylamphetamine (100 mg/kg). The same dose of methylamphetamine causes approximately 50% depletion of caudate dopamine 2 weeks after the injection. We suggest that the formation of 6-hydroxydopamine from endogenous dopamine is responsible for the neurotoxicity to dopamine terminals seen after methylamphetamine administration.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D006892:Hydroxydopamines / Q000096:biosynthesis*; D008297:Male; D008694:Methamphetamine / Q000378:metabolism*; D009422:Nervous System Diseases / Q000139:chemically induced; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains
D006892:Hydroxydopamines; D015102:3,4-Dihydroxyphenylacetic Acid; D008694:Methamphetamine; D016627:Oxidopamine; D004298:Dopamine