Protein-energy malnutrition alters brain thyrotropin-releasing hormone and cyclo (His-Pro) in the neonatal rat.
To evaluate effects of protein-energy malnutrition on the brain neuropeptides thyrotropin-releasing hormone (TRH) and cyclo (His-Pro) in the cerebellum and the remainder brain, we studied neonatal rats in the lactational period. Protein-energy malnutrition caused an increase in cyclo (His-Pro) concentrations, but not in TRH concentrations, in the neonatal cerebellum. In the remainder brain, a reduction in cyclo (His-Pro) concentrations occurred with an increase in TRH concentrations. These data indicate that protein-energy malnutrition affects both brain TRH and cyclo (His-Pro) in the neonatal rats during lactation.
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D005260:Female; D010456:Peptides, Cyclic / Q000378:metabolism*; D010879:Piperazines / Q000378:metabolism*; D011247:Pregnancy; D011502:Protein-Energy Malnutrition / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism*
D010456:Peptides, Cyclic; D010879:Piperazines; D013973:Thyrotropin-Releasing Hormone; C015924:histidyl-proline diketopiperazine