title: Investigations on Dieffenbachia amoena Gentil. I: Endocrine effects and contraceptive activity.
abstract: Contraceptive activity and the correlated endocrine alterations of an aqueous extract of the leaves of Dieffenbachia amoena were investigated. In female Wistar rats the extract, given for 4 days during the estrous cycle, induced significant variations of luteinizing hormone (LH), follicle-stimulating hormone (FSH), prolactin (PRL) progesterone and 17 beta-estradiol levels. It also determined a reversible interruption of the estrous cycle with consequent temporary inhibition of ovulation.
mesh_terms: D000818:Animals; D003270:Contraceptive Agents / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000097:blood; D005260:Female; D005298:Fertility / Q000187:drug effects; D005640:Follicle Stimulating Hormone / Q000097:blood; D010053:Ovary / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D010947:Plants, Toxic; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D014626:Vaginal Smears
chemical_list: D003270:Contraceptive Agents; D010936:Plant Extracts; D011374:Progesterone; D004958:Estradiol; D005640:Follicle Stimulating Hormone