The management of musculoskeletal problems in hemophilia. Part I. Principles of medical management of hemophilia.
Musculoskeletal bleeding in general and arthropathy in particular are the central problems among many in the two major forms of hemophilia: classic hemophilia, caused by factor VIII deficiency, and Christmas disease, caused by factor IX deficiency. Currently available replacement therapy, if properly used in a multidisciplinary setting, should provide significant benefit to hemophilic patients despite its cost and occasional complications.
D000743:Anemia, Hemolytic / Q000209:etiology; D005164:Factor IX / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D005169:Factor VIII / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D005340:Fibrinogen / Q000627:therapeutic use; D006395:Hemarthrosis / Q000209:etiology; D006467:Hemophilia A / Q000097:blood / Q000150:complications / Q000628:therapy*; D002836:Hemophilia B / Q000097:blood / Q000150:complications / Q000628:therapy; D006487:Hemostasis; D006509:Hepatitis B / Q000635:transmission; D006801:Humans; D065227:Transfusion Reaction
C026912:cryoprecipitate coagulum; D005169:Factor VIII; D005164:Factor IX; D005340:Fibrinogen