Increase of valproate-induced hyperammonemia in normal subjects by carbohydrate intake.
Sodium valproate-induced hyperammonemia in normal subjects is increased by the intake of carbohydrates--rapidly or slowly absorbed sugars, given by mouth or IV injection. The hyperammonemia is maximal about 3 hours after carbohydrate administration. This relation between carbohydrate and ammonia metabolism has not been described previously.
D000641:Ammonia / Q000097:blood* / Q000378:metabolism; D050260:Carbohydrate Metabolism; D006801:Humans; D008297:Male; D014635:Valproic Acid / Q000378:metabolism / Q000494:pharmacology*
D014635:Valproic Acid; D000641:Ammonia