title: Action of aflatoxin B1 on pregnant rats.
abstract: The hepatotoxic effect of aflatoxin B1 on pregnant rats was studied by injecting the animals in the first 14 days of pregnancy with doses equivalent ot 1/1,000 ppm; the rats were killed at the end of pregnancy. Liver lesions such as clear intumescence, granular dystrophy, Kupffer cell hyperplasia, pycnosis and atypical mitoses were shown; concomitantly regeneration phenomena were expressed by an increased incidence of binucleated cells and mitosis. Fertility decreased after aflatoxin and embryonary resorptions, malformations and developmental retardations occurred.
mesh_terms: D000014:Abnormalities, Drug-Induced; D000348:Aflatoxins / Q000009:adverse effects*; D000818:Animals; D005260:Female; D005333:Fetus / Q000187:drug effects; D008099:Liver / Q000187:drug effects*; D008115:Liver Regeneration / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects; D051381:Rats
chemical_list: D000348:Aflatoxins