title: Bleeding disorder from the "fat overload" syndrome.
abstract: The fat overload syndrome developed in a 7-yr-old girl receiving total parenteral nutrition with 20% Intralipid. She developed a bleeding disorder characterized by severe hematemesis that appeared to be due to abnormal platelet function associated with platelet phagocytosis of lipid demonstrable by electron microscopy. The platelet defect and bleeding reversed when the lipemia cleared.
mesh_terms: D001791:Blood Platelet Disorders / Q000209:etiology; D002648:Child; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects*; D005260:Female; D006396:Hematemesis / Q000209:etiology*; D006801:Humans; D006949:Hyperlipidemias / Q000209:etiology*; D008854:Microscopy, Electron; D010288:Parenteral Nutrition; D010289:Parenteral Nutrition, Total; D010974:Platelet Aggregation
chemical_list: D005217:Fat Emulsions, Intravenous