title: A widespread epidemic of mild necrotizing enterocolitis of unknown cause.
abstract: Within a 28-day period, necrotizing enterocolitis (NEC) developed in 20 of 38 infants (53%). Patients with NEC were compared with the remaining 18 infants hospitalized at the same time who did not acquire the disease. Complications of pregnancy and labor-delivery and infant care practices did not differ between groups. Mean chronologic age was significantly different between patients with NEC and those without, 29 days v 77 days. Mean postconceptional age at the time of the outbreak was also significantly different, 33.4 weeks v 42.3 weeks. None of the cultures demonstrated a specific common pathogen. The low mortality (5%) and the large number of infants affected suggest an atypical out-break of NEC. We could not isolate a causative agent despite extensive epidemiologic investigation, and suggest that postconceptional age delineates those at risk.
mesh_terms: D000367:Age Factors; D001724:Birth Weight; D003013:Clostridium / Q000302:isolation & purification; D003428:Cross Infection / Q000453:epidemiology* / Q000382:microbiology; D004196:Disease Outbreaks / Q000453:epidemiology*; D004750:Enteral Nutrition; D004761:Enterocolitis, Pseudomembranous / Q000453:epidemiology* / Q000382:microbiology; D006801:Humans; D007087:Illinois; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000453:epidemiology; D007363:Intensive Care Units, Neonatal