Studies on the synthesis of the fluorescent bases from phenylalanine transfer ribonucleic acids.
L-Serine has been transformed into (R)-[2-carboxy-2-[(methoxycarbonyl) amino]ethyl]triphenylphosphonium chloride in seven steps. The Wittig reaction of this compound with 1-benzyl-7-formylwye followed by successive methylation and reduction has produced (S)-wybutine.
D007202:Indicators and Reagents; D009943:Organophosphorus Compounds / Q000138:chemical synthesis*; D012346:RNA, Transfer, Amino Acyl; D012441:Saccharomyces cerevisiae; D012694:Serine; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; D009943:Organophosphorus Compounds; D012346:RNA, Transfer, Amino Acyl; D012694:Serine; C044275:(2-carboxy-2-((methoxycarbonyl)amino)ethyl)triphenylphosphonium