[Mechanisms of the action of psychotropic preparations on transport ATPases].
Psychotropic drugs, especially neuroleptics, reversibly and noncompetitively inhibit the activity of Na, K-ATPase of the brain and Ca, Mg-ATPase of the sarcoplasmatic reticulum. The inhibitory effect is more pronounced versus the sarcoplasmatic reticulum and less marked versus purified enzymatic preparations. It is not much dependable on variations in the protein concentration of enzymatic preparations and is not related to drug binding to sulfhydryl groups of an enzyme. The inhibitory action of the drugs declines or completely disappears after treating the membranous preparations with phospholipase A. That psychotropic drugs have a predominant effect on the lipid structure of the membrane was supported during examination of EPR spectra of lipid spin labels.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects*; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004789:Enzyme Activation / Q000187:drug effects; D066298:In Vitro Techniques; D008563:Membrane Lipids / Q000494:pharmacology; D008565:Membrane Proteins / Q000494:pharmacology; D008578:Meninges / Q000201:enzymology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011817:Rabbits; D012519:Sarcoplasmic Reticulum / Q000201:enzymology
D008563:Membrane Lipids; D008565:Membrane Proteins; D011619:Psychotropic Drugs; D000251:Adenosine Triphosphatases; D000252:Calcium-Transporting ATPases
O nekotorykh mekhanizmakh deĭstviia psikhotropnykh preparatov na transportnye ATF-azy.