title: Arthritis in rabbits induced by killed Neisseria gonorrhoeae and gonococcal lipopolysaccharide.
abstract: Intraarticular injections of viable N, gonorrhoeae, killed N. gonorrhoeae or gonococcal lipopolysaccharide (LPS) in rabbits' knees caused an acute, polymorphonuclear synovitis with abscess formation 24-72 h after the injection. At 5-7 days, a mononuclear infiltration with synovial lining cell hyperplasia developed, which in some rabbits persisted for one month. Gonococcal LPS, in amounts of 5 micrograms or greater, always caused a marked synovitis indistinguishable from that produced by viable N. gonorrhoeae. Gonococcal outer membrane protein used as a control in these experiments caused no or minimal synovitis in concentrations 50-fold higher than those used in the LPS inoculation experiments. These studies should provide a model to investigate the role of LPS in the arthritis associated with gonococcal infection.
mesh_terms: D000038:Abscess / Q000473:pathology; D000818:Animals; D001170:Arthritis, Infectious / Q000209:etiology* / Q000473:pathology; D002470:Cell Survival; D002473:Cell Wall / Q000032:analysis; D006069:Gonorrhea / Q000473:pathology*; D006801:Humans; D007270:Injections, Intra-Articular; D007717:Knee / Q000473:pathology; D008070:Lipopolysaccharides / Q000633:toxicity*; D009344:Neisseria gonorrhoeae / Q000032:analysis; D011817:Rabbits; D013583:Synovial Membrane / Q000473:pathology; D013585:Synovitis / Q000473:pathology; D013997:Time Factors
chemical_list: D008070:Lipopolysaccharides