title: HLA phenotype and insulin antibody production.
abstract: HLA phenotypes have been determined in 79 patients as part of a prospective study of factors governing the immune response to injected insulin. IgG insulin antibody levels 6 months after starting treatment with bovine insulin were significantly higher in patients bearing HLA-DR7 and this in conjunction with the lack of a similar pattern in the IgG response to Helix pomatia haemocyanin, suggests the presence of an immune response gene for insulin. The hyporesponsiveness of HLA-B8/DR3/C4AQ0 positive individuals is more likely to reflect a non-specific abnormality of immunity.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005802:Genes, MHC Class II; D015803:HLA-DR3 Antigen; D015804:HLA-DR4 Antigen; D015809:HLA-DR7 Antigen; D006433:Hemocyanins / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007330:Insulin Antibodies / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011446:Prospective Studies
chemical_list: D015803:HLA-DR3 Antigen; D015804:HLA-DR4 Antigen; D015809:HLA-DR7 Antigen; D000949:Histocompatibility Antigens Class II; D007074:Immunoglobulin G; D007330:Insulin Antibodies; D006433:Hemocyanins