Macrophage antitumor activity: impaired responsiveness to interferon-gamma of macrophages from genetically defective mice.
Macrophages (M phi) from the genetically defective mouse strains C3H/HeJ, A/J and P/J were unable to develop high levels of antitumor activities when stimulated either with immune recombinant interferon gamma (IFN-gamma) or with nonimmune IFN-alpha and IFN-beta, as compared to M phi or normal C3H/HeN mice. IFN-gamma appeared to be an exceptionally good activator of C3H/HeN M phi, as it could induce tumoricidal capacities 3000 times more efficiently than nonimmune IFN. The high efficiency of IFN-gamma as M phi activator was indeed confirmed on defective M phi. In fact, at high doses IFN-gamma could also induce significant levels of both cytolytic and cytostatic activity in M phi of A/J and P/J mice, although it could not increase cytotoxic activities of C3H/HeJ M phi.
D000818:Animals; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D007371:Interferon-gamma / Q000494:pharmacology*; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D008817:Mice, Mutant Strains; D009374:Neoplasms, Experimental / Q000276:immunology; D013045:Species Specificity
D007371:Interferon-gamma