On the nature of the vasoreactivity depressing factor (VDF) in inflammation and anaphylaxis in the rat and mouse.
In anaphylactic paw edema the reactivity of blood vessels to norepinephrine in the isolated perfused hind legs of rats and mice is reduced. A vasoreactivity depressing factor was postulated and searched for. PAF-acether, histamine and lipoxygenase products were found as being possibly responsible for depression of the vascular reactivity.
D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D000527:Alprostadil; D000707:Anaphylaxis / Q000503:physiopathology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology; D005260:Female; D006632:Histamine / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007249:Inflammation / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009638:Norepinephrine / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D011720:Pyrazoles / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology; D014667:Vasopressins / Q000032:analysis*
D000893:Anti-Inflammatory Agents; D010972:Platelet Activating Factor; D011458:Prostaglandins E; D011720:Pyrazoles; D014667:Vasopressins; D012701:Serotonin; D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D006632:Histamine; D011464:Epoprostenol; D000527:Alprostadil; D009638:Norepinephrine; D007213:Indomethacin