Gold-induced thrombocytopenia: detection of anti-platelet antibody.
We describe a patient with rheumatoid arthritis who developed a sudden, severe thrombocytopenia during the early stages of treatment with sodium aurothiomalate. There were no haemorrhagic manifestations and the thrombocytopenia was rapidly corrected by corticosteroid treatment. The presence of anti-platelet IgG was demonstrated in serial serum specimens by an enzyme-linked immunosorbent assay (ELISA). Although most of this reactivity proved to be directed against allogeneic antigens on donor platelets, IgG reactive with autologous platelets was detected in the first serum sample obtained.
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D001792:Blood Platelets / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006052:Gold Sodium Thiomalate / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis*; D013921:Thrombocytopenia / Q000139:chemically induced* / Q000276:immunology
D001323:Autoantibodies; D007074:Immunoglobulin G; D006052:Gold Sodium Thiomalate