[Changes in the metastasis of experimental tumors and in the antimetastatic effect of cytostatics in their pharmacological action on adrenergic processes].
Different pharmacologic drugs (isadrin, obsidan, phentolamine) changing adrenergic processes are shown to have different effect on the growth and development of lung metastases. An increase in the antimetastatic effect of some cytostatics is also observed in mice with Lewis carcinoma and melanoma B-16 under the influence of isadrin, a stimulator of beta-adrenoreceptors. In authors' opinion, isadrin changes microcirculation in lungs and prevents inhibition of the immune reactivity in animals with metastatic tumours, thus contributing to inhibition of the development and growth of metastases.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D007111:Immunity, Cellular / Q000187:drug effects; D007545:Isoproterenol / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000276:immunology; D008297:Male; D008545:Melanoma / Q000188:drug therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D010646:Phentolamine / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D011941:Receptors, Adrenergic / Q000187:drug effects*; D013852:Thiotepa / Q000627:therapeutic use; D013997:Time Factors
D000970:Antineoplastic Agents; D011941:Receptors, Adrenergic; D003520:Cyclophosphamide; D013852:Thiotepa; D011433:Propranolol; D007545:Isoproterenol; D010646:Phentolamine
Izmenenie metastazirovaniia éksperimental'nykh opukholeĭ i antimetastaticheskogo éffekta tsitostatikov pri farmakologicheskikh vozdeĭstviiakh na adrenergicheskie protsessy.