Ondine's curse: therapeutic trial of dimefline.
Ondine's curse is a rare disorder characterized by primary failure of central regulation of breathing, resulting in severe hypoventilation during sleep. This report describes a 14-year-old girl with both this disorder and hypergonadotropic hypogonadism. As a therapeutic trial, dimefline was administered orally, which was effective in deepening respiration for certain periods of sleep, during which time blood gas levels improved significantly.
D000293:Adolescent; D004958:Estradiol / Q000097:blood; D005260:Female; D005419:Flavonoids / Q000627:therapeutic use*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007006:Hypogonadism / Q000150:complications*; D007986:Luteinizing Hormone / Q000097:blood; D012119:Respiration; D012891:Sleep Apnea Syndromes / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D012895:Sleep, REM / Q000502:physiology
D005419:Flavonoids; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; C015154:dimefline