The importance of corticoids added to continued treatment with Factor VIII concentrates in the suppression of inhibitors in haemophilia A.
A protocol is presented to suppress inhibitors in haemophilia A using continued treatment with f. VIII (50 U/kg b.w./day) and fluprednisolone (0.5 mg/kg b.w., for 21 days) until reaching correct in vivo recovery after therapeutic administration. 5 high responder patients were treated whose inhibitors were detected at least 2 years before beginning the treatment. The inhibitors were eradicated in 4 patients using continued treatment for between 4 and 24 months. Patient 1 was treated exclusively with factor and the others also with corticoids when the level was 0 B.U. (or 20 B.U., patient 4). The patients began tri-weekly prophylactic treatment and rehabilitation exercises after recovery test normalization. After progressive reduction of the prophylactic treatment they started on demand treatment. After more than 5 months of this treatment no anamnestic response has been detected in any patient, in spite of several factor VIII administrations.
D000293:Adolescent; D000328:Adult; D000941:Antigens / Q000378:metabolism; D002648:Child; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005169:Factor VIII / Q000037:antagonists & inhibitors / Q000276:immunology / Q000378:metabolism / Q000627:therapeutic use*; D005477:Fluprednisolone / Q000627:therapeutic use*; D006467:Hemophilia A / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male
D000941:Antigens; D005169:Factor VIII; D005477:Fluprednisolone