The use of sodium 2-mercaptoethane sulfonate to prevent cyclophosphamide cystitis.
In 2 patients receiving bone marrow transplantation sodium 2-mercaptoethane sulfonate has proved efficacious in preventing the serious problem of cyclophosphamide cystitis by regional detoxification of acrolein. We detail the first use of sodium 2-mercaptoethane sulfonate in the United States. We are cautiously enthusiastic and optimistic that the simultaneous administration of sodium 2-mercaptoethane sulfonate and cyclophosphamide will decrease if not eliminate cyclophosphamide-induced carcinoma.
D016026:Bone Marrow Transplantation; D002648:Child; D003520:Cyclophosphamide / Q000009:adverse effects*; D003556:Cystitis / Q000139:chemically induced / Q000517:prevention & control*; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000628:therapy; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007223:Infant; D008297:Male; D008623:Mercaptoethanol / Q000031:analogs & derivatives*; D015080:Mesna / Q000627:therapeutic use*
D008623:Mercaptoethanol; D003520:Cyclophosphamide; D015080:Mesna