title: Heterogeneity of the tolerant state in rats with long established skin grafts.
abstract: Tolerance in rats with long established allogeneic skin grafts brought about by the neonatal inoculation of hybrid lymphomyeloid cells is immunologically heterogeneous because 2 states of tolerance may be defined operationally as fully and partially tolerant. T cells from fully tolerant donors transfer tolerance and are unresponsive in MLC, but T cells from partially tolerant donors do not transfer tolerance and are modestly responsive in MLC. A state of tolerance may exist without detectable suppression. Therefore, tolerance, traditionally defined as the permanent acceptance of an allogeneic skin graft, does not reflect a uniform immunologic state.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002465:Cell Movement; D007108:Immune Tolerance; D007116:Immunization, Passive; D007959:Lymphocyte Culture Test, Mixed; D051381:Rats; D011916:Rats, Inbred F344; D016038:Skin Transplantation; D013997:Time Factors; D014184:Transplantation, Homologous