Arachidonic acid cascade and anti-hypoxic drugs.
The anti-hypoxic effect of drugs that inhibit different steps of arachidonic acid metabolism was studied using an experimental model of acute hypobaric hypoxia in mice. The drugs investigated were chloroquine, betamethasone, chlorpromazine (phospholipase A2 inhibitors), ketoprofen (cyclo-oxygenase inhibitor) and imidazole (TxA2 synthetase inhibitor). Prostacyclin (PGI2) and PGF2 alpha were also studied. The results show that all the inhibitors of arachidonic acid metabolism manifest an anti-hypoxic effect of a various degree. PGF2 alpha had a deleterious effect, and PGI2 showed a marked anti-hypoxic effect. The results suggest that it is advantageous to search for anti-hypoxic drugs among the blockers of arachidonic acid cascade.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000096:biosynthesis*; D001623:Betamethasone / Q000627:therapeutic use; D002738:Chloroquine / Q000627:therapeutic use; D002746:Chlorpromazine / Q000627:therapeutic use; D016861:Cyclooxygenase Inhibitors; D015237:Dinoprost; D011464:Epoprostenol / Q000627:therapeutic use; D005260:Female; D000860:Hypoxia / Q000188:drug therapy* / Q000378:metabolism; D007093:Imidazoles / Q000627:therapeutic use; D007660:Ketoprofen / Q000627:therapeutic use; D051379:Mice; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D054467:Phospholipases A2; D011460:Prostaglandins F / Q000627:therapeutic use; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors
D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D007093:Imidazoles; D011460:Prostaglandins F; D016718:Arachidonic Acid; C029899:imidazole; D002738:Chloroquine; D007660:Ketoprofen; D001623:Betamethasone; D015237:Dinoprost; D011464:Epoprostenol; D010741:Phospholipases A; D054467:Phospholipases A2; D013930:Thromboxane-A Synthase; D002746:Chlorpromazine