Prostaglandins as mediators of vasotonia in the immature retina.
In vivo observations of the immature beagle puppy retina indicates that in general O2-breathing induces vasoconstriction whereas CO2 or CO2 combined with O2 induces vasodilation. It was the goal of this study to determine whether a specific correlation could be found between this pattern of vascular response to changes in blood gas content and production of prostaglandins in the eye. Prostaglandin production by puppy choroidal and retinal tissues and platelets exposed in vitro to these gas combinations was such that it appears platelet-derived thromboxane could have a significant influence in determining retinal vasotonia.
D000818:Animals; D000831:Animals, Newborn; D002245:Carbon Dioxide / Q000502:physiology; D004285:Dogs; D011464:Epoprostenol / Q000494:pharmacology; D066298:In Vitro Techniques; D010100:Oxygen / Q000502:physiology; D011453:Prostaglandins / Q000096:biosynthesis / Q000502:physiology*; D012171:Retinal Vessels / Q000187:drug effects / Q000502:physiology*; D014655:Vascular Resistance; D014661:Vasoconstriction; D014664:Vasodilation
D011453:Prostaglandins; D002245:Carbon Dioxide; D011464:Epoprostenol; D010100:Oxygen