Increased phospholipid methylation in the myocardium of hyperthyroid rats.
Administration of L-thyroxine (1 mg/kg) to adult rats results in cardiac hypertrophy and enhanced contractility. Phosphatidylcholine synthesis through methylation of phosphatidylethanolamine by S-adenosylmetionine in enhanced in the myocardium of hyperthyroid rats. Increased microsomal methylation occurs pari passu with the development of cardiac hypertrophy and may be partly responsible for preservation of cardiac performance.
D000818:Animals; D006332:Cardiomegaly / Q000209:etiology; D004195:Disease Models, Animal; D006980:Hyperthyroidism / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D008745:Methylation; D008861:Microsomes / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D012436:S-Adenosylmethionine / Q000378:metabolism; D013974:Thyroxine
D010743:Phospholipids; D012436:S-Adenosylmethionine; D013974:Thyroxine