[Animal experiment studies of chronic thiamine deficiency. Changes in carbohydrate and amino acid metabolism under resting and load conditions].
The metabolic effects of thiamine deficiency on the metabolism of lactate, acid-base and amino acids were evaluated both with and without muscular exercise in a controlled animal experiment. Thiamine deficiency - in good correlation with its biologic halftime and also with reports in the literature - caused with a latency of 17-56 days and statistically proven in parallel the following effects: hyperlactemia; in comparison to controls elevated plasma concentrations of threonine, alanine, glutamic acid, glutamine, histidine, methionine, taurine, valine, isoleucine and leucine; distinctly lowered - also in comparison to controls - plasma concentrations of arginine and tryptophan. Furthermore, in the thiamine deficient rats predetermined muscular exercise caused the following effects, also occurring concomitantly: life threatening lactacidosis; marked - statistically prover - disturbance of the homeostasis of alanine, glycine, methionine and arginine; distinctly - and statistically significant - elevated plasma concentration of proline; statistically significantly lowered plasma concentrations of taurine. The reasons for all these changes under thiamine deficiency is most likely a metabolic one primarily due to a disturbance of the utilization of pyruvate in the liver. An additional disturbance of both the transsulfuration pathway and the Krebs-Henseleit-cycle seems probable. The physiologic regulation of pyruvate, lactate, alanine, serine and tyrosine during muscular exercise in correlation to the controls is being discussed.
D000596:Amino Acids / Q000097:blood*; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D002241:Carbohydrates / Q000097:blood*; D002245:Carbon Dioxide / Q000097:blood; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D008297:Male; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains; D012146:Rest; D013550:Swimming; D013832:Thiamine Deficiency / Q000097:blood*
D000596:Amino Acids; D001639:Bicarbonates; D002241:Carbohydrates; D007773:Lactates; D002245:Carbon Dioxide; D019344:Lactic Acid; D010100:Oxygen
Tierexperimentelle Studie zum chronischen Thiaminmangel. Veränderungen des Kohlenhydrat- und Aminosäurenstoffwechsels unter Ruhe- und Belastungsbedingungen.