Allergic contact dermatitis from methylisothiocyanate in soil disinfectants.
Observations on nine patients with occupational dermatitis from methylisothiocyanate (MITC) lead to the following conclusions: 1. MITC causes primarily a toxic dermatitis, but as a strong sensitizer it induces sensitization as well. 2. Cross reactions between MITC and benzylisothiocyanate, the active agent of Sulbentin antimycotics, were not seen. 3. In patient a MITC acid burn on one foot and leg caused systemic poisoning from absorption with reversible damage to the liver parenchyma.
D000328:Adult; D002057:Burns, Chemical / Q000209:etiology; D056486:Chemical and Drug Induced Liver Injury; D003877:Dermatitis, Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000139:chemically induced*; D004202:Disinfectants / Q000009:adverse effects* / Q000506:poisoning; D005260:Female; D006801:Humans; D017879:Isothiocyanates; D012987:Soil; D013861:Thiocyanates / Q000009:adverse effects* / Q000506:poisoning
D004202:Disinfectants; D017879:Isothiocyanates; D012987:Soil; D013861:Thiocyanates; C005227:methyl isothiocyanate