[Initial stages in the mechanism of protein glycosylation in human breast neoplasms].
It is discussed the rol of lipid intermediates in the biosynthesis of eucaryotic glycoproteins. Microsomal fraction isolated from malignant human breast tumors transferred Man and Glc from GDP-(14 C)-Man and UDP-(14 C)-Glc into lipid linked sugars and glycoproteins. The transference of Dol-PP-oligosaccharide to endogenous acceptor proteins was catalyzed for the same microsomal fraction.
D001943:Breast Neoplasms / Q000378:metabolism*; D004287:Dolichol Monophosphate Mannose / Q000378:metabolism; D004492:Edetic Acid / Q000494:pharmacology; D006017:Glycolipids / Q000502:physiology*; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D008861:Microsomes / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism*; D009844:Oligosaccharides / Q000378:metabolism; D011104:Polyisoprenyl Phosphate Oligosaccharides / Q000378:metabolism
D006017:Glycolipids; D006023:Glycoproteins; D009363:Neoplasm Proteins; D009844:Oligosaccharides; D011104:Polyisoprenyl Phosphate Oligosaccharides; C024962:dolichyl diphosphate oligosaccharides; D004287:Dolichol Monophosphate Mannose; D004492:Edetic Acid
Primeras etapas en el mecanismo de glicosilación de proteínas en neoplasias mamarias humanas.