The effect of enteral nutritional support on skeletal muscle protein synthesis and whole-body protein turnover in fasted surgical patients.
Whole-body and muscle protein turnover have been studied in surgical patients, before abdominal surgery after an 18-h fast, using infusion of 1-[13C]leucine. Four patients received an unmodified hospital diet and four received extra nutritional support (1800 kcal, 70 g protein) by naso-jejunal tube for 7-10 d previously. In patients who received nutritional support there were significantly greater values of whole-body protein synthesis (+42 per cent, P less than 0.05) and breakdown (+45 per cent, P less than 0.01) and muscle protein synthesis (+36 per cent, P less than 0.05) than in those who received the unmodified hospital diet.
D000368:Aged; D004032:Diet; D004750:Enteral Nutrition; D005215:Fasting; D005526:Food, Formulated; D005770:Gastrointestinal Neoplasms / Q000601:surgery* / Q000628:therapy; D006801:Humans; D007441:Intubation, Gastrointestinal; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism*; D011300:Preoperative Care; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism*
D011506:Proteins