Naloxone does not affect ventilatory responses to hypoxia and hypercapnia in rats.
Ventilatory responses (tidal volume, respiratory frequency, and minute ventilation) to steady-state hypoxia and steady-state hypercapnia were measured plethysmographically in awake unrestrained adult rats, before and after subcutaneous injection of placebo (saline) naloxone in doses up to 5.0 mg/kg. Naloxone did not alter the ventilatory responses to hypoxia or hypercapnia.
D000818:Animals; D002245:Carbon Dioxide / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D010100:Oxygen / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects*; D013223:Statistics as Topic; D013990:Tidal Volume
D002245:Carbon Dioxide; D009270:Naloxone; D010100:Oxygen