Glutamine homeostasis: role of pCO2 in regulating arterial glutamine in metabolic acidosis.
In chronic metabolic acidosis arterial plasma glutamine concentration is reduced 46%. This effect is attributable to a reduction in arterial pCO2 rather than acidemia since elevating pCO2 returns glutamine toward the control level. The extracellular glutamine precursors ammonia and glutamate exhibit a reciprocal decline with the elevation in pCO2. This reduction in metabolic acidosis appears to play an important role in sparing glutamine for renal base generation.
D000138:Acidosis / Q000139:chemically induced / Q000503:physiopathology*; D000643:Ammonium Chloride; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood*; D005973:Glutamine / Q000097:blood*; D006706:Homeostasis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000643:Ammonium Chloride; D005973:Glutamine; D002245:Carbon Dioxide