[Action of pristinamycin on Chlamydia].
In vitro study on C. psittaci and C. trachomatis demonstrates that pristinamycin is active in a very small dose. With 5 g/l, inclusions are rare. To study pristinamycin activity in vivo, we used mice infected IP with C. psittaci. Mortality in the control group was 70%. Three groups of mice received 25 mg/kg, 50 mg/kg and 100 mg/kg pristinamycin respectively. The antibiotic was active in the 100 mg/kg dosage which is the therapeutic dosage. Due to its action on Gonococcus, it would be of interest to study pristinamycin in patients with sexually transmitted disease.
D000818:Animals; D002689:Chlamydia / Q000187:drug effects*; D002690:Chlamydia Infections / Q000188:drug therapy*; D005260:Female; D051379:Mice; D008809:Mice, Inbred C3H; D008826:Microbial Sensitivity Tests; D014769:Virginiamycin / Q000494:pharmacology* / Q000627:therapeutic use
D014769:Virginiamycin
Action de la pristinamycine sur les Chlamydia.