Genetic control of immune responses to Schistosoma japonicum.
The mouse IgE antibody response to S. japonicum antigen (Sj) was found to be under control of a gene(s) linked to the major histocompatibility complex. In some strains but not all among low responders, however, T cell responsiveness to Sj could be demonstrated by the induction of carrier effect as well as by proliferation response. Resistance to reinfection with a large dose of S. japonicum cercariae was demonstrated in most strains examined, except C57BL/6, irrespective of the immune responsiveness. Further studies will be needed to elucidate whether genetically regulated immune responses may affect susceptibility to or pathogenesis of schistosomiasis japonica in the mouse.
D000818:Animals; D000906:Antibodies / Q000276:immunology; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics*; D007073:Immunoglobulin E; D051379:Mice; D008815:Mice, Inbred Strains; D012549:Schistosoma japonicum / Q000276:immunology; D012552:Schistosomiasis / Q000276:immunology*
D000906:Antibodies; D006183:H-2 Antigens; D007073:Immunoglobulin E