Amyloid neuropathy: relationship between amyloid fibrils and macrophages.
A case of amyloid neuropathy associated with a multiple myeloma IgG light chain is reported. Under light microscopy the peripheral nerve exhibited several amyloid deposits. Electron microscopy revealed numerous amyloid deposits; at their periphery, macrophagic histiocytes were observed, containing a few tufts of parallel fibrils in their cytoplasm. A few plasma cells were scattered in the endoneurium and did not exhibit such a relationship. These findings resemble those recently observed in stem-cell cultures of IgG lambda chain human myeloma.
D000682:Amyloid / Q000032:analysis*; D001707:Biopsy, Needle; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007147:Immunoglobulin Light Chains / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D008264:Macrophages / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology / Q000648:ultrastructure*; D009423:Nervous System Neoplasms / Q000473:pathology / Q000648:ultrastructure*; D010543:Peroneal Nerve / Q000473:pathology / Q000648:ultrastructure*
D000682:Amyloid; D007074:Immunoglobulin G; D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains