[Antibacterial and genotoxic properties of 33 mycotoxins].
Most of the 33 fungal metabolites tested provoke: Bacterial growth inhibition of Bacillus thuringiensis similar to lethal effect of antibiotics. Positive response in the 'Rec' assay using strains of Bacillus subtilis; this fact shows that these toxins are DNA modifying agents. Enlargement of cell volume in the first bacteria species; this cell-abnormality induction resembles those obtained with mitomycin C. Correlation between elongation of cells (filamentation) and in vivo carcinogenicity of mycotoxins is discussed. The filamentation should be an expression of a perturbated DNA replication (S.O.S.-error prone repair) as the consequence of DNA damages induced by genotoxic agents (i.e. carcinogens).
D001412:Bacillus subtilis / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D001413:Bacillus thuringiensis / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism; D004269:DNA, Bacterial / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D009183:Mycotoxins / Q000494:pharmacology*; D009691:Nucleic Acid Denaturation; D013045:Species Specificity
D004269:DNA, Bacterial; D009183:Mycotoxins
Propriétés antibactériennes et génotoxiques de 33 mycotoxines.