title: An unusual skin reaction following local anesthetic injection. Review of the literature and report of four cases.
abstract: Four cases of an unusual skin eruption related to mandibular block injection are presented. The authors suggest an immunologic basis for the reaction, probably to the methylparaben preseravtive, and discuss a possible pathogenic mechanism. The medical-dental literature concerning untoward reactions to lidocaine is reviewed; particular attention is given alleged allergic reactions.
mesh_terms: D001183:Arthus Reaction / Q000139:chemically induced; D002648:Child; D003875:Drug Eruptions / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000209:etiology; D004361:Drug Tolerance; D004890:Erythema / Q000139:chemically induced; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000008:administration & dosage / Q000009:adverse effects*; D008340:Mandibular Nerve; D009407:Nerve Block; D010328:Patch Tests
chemical_list: D008012:Lidocaine