Effect of thymoxamine in the relief of pain and rate of healing in ischaemic leg ulceration.
A small uncontrolled pilot study was carried out in 6 patients with ischaemic leg ulceration in which pain was severe to assess the effectiveness of thymoxamine in the relief of pain and on the rate of healing. Patients were treated for 3 days with intravenous injections of 0.1 mg thymoxamine/kg body weight and then with oral 40 mg thymoxamine 4-times daily for a further month. The results showed that there appeared to be a definite improvement in pain during intravenous therapy and this was maintained to a large extent, although not so definite, on oral therapy. No enhanced rate of healing, however, was evident.
D000284:Administration, Oral; D000368:Aged; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007511:Ischemia / Q000188:drug therapy*; D007866:Leg / Q000098:blood supply*; D007871:Leg Ulcer / Q000188:drug therapy*; D008297:Male; D013948:Moxisylyte / Q000008:administration & dosage / Q000627:therapeutic use*; D010146:Pain / Q000188:drug therapy*; D010865:Pilot Projects
D013948:Moxisylyte