The effects of antibiotic-supplemented bone allografts on contaminated, partially avulsive fractures of the canine ulna.
The use of antibiotic-supplemented bone allograft as a material for placement in contaminated fractures of the dog ulna was investigated. Demineralized, freeze-dried bone allografts mixed with antibiotics and gelatin were placed in five fractures contaminated with Staphylococcus aureus (Washington Hospital strain) and Pseudomonas aeruginosa (PA 220). The results of treatment with antibiotic-supplemented bone allografts were compared with the results of conventional treatment in five additional experimental animals in which fractures contaminated with S. aureus and P. aeruginosa were created. The five fractures treated by conventional methods developed acute osteomyelitis and nonunion, whereas the ASBA-treated fractures resulted in bone union without infection. ASBA-treated fractures were stable and had 89% of the shearing strength of the non-fractured, contralateral ulnae five months after treatment.
D000818:Animals; D016025:Bone Transplantation; D002512:Cephalothin / Q000008:administration & dosage*; D004285:Dogs; D008297:Male; D010019:Osteomyelitis / Q000382:microbiology / Q000517:prevention & control; D011552:Pseudomonas Infections / Q000382:microbiology / Q000517:prevention & control*; D011550:Pseudomonas aeruginosa; D013203:Staphylococcal Infections / Q000382:microbiology / Q000517:prevention & control*; D013211:Staphylococcus aureus; D014021:Tissue Preservation / Q000379:methods; D014031:Tobramycin / Q000008:administration & dosage*; D014457:Ulna / Q000033:anatomy & histology / Q000502:physiology; D014458:Ulna Fractures / Q000382:microbiology / Q000503:physiopathology / Q000601:surgery*; D014945:Wound Healing
D002512:Cephalothin; D014031:Tobramycin