Cerebral insulin-like immunoreactivity in rats and mice. Drastic decline during postnatal ontogenesis.
We studied the behavior of the insulin-like immunoreactivity in brains of rats and mice during the first 20 d post natum by immunohistochemistry and radioimmunoassay. It was found that a dramatic decline in the concentration of the peptide, accompanied by a strong reduction of immunoreactive cells, takes place during this period. A possible role of cerebral insulin as a promoter of nerve cell growth and development is briefly discussed.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001923:Brain Chemistry; D003593:Cytoplasm / Q000032:analysis; D003712:Dendrites / Q000032:analysis; D006624:Hippocampus / Q000032:analysis; D006651:Histocytochemistry; D007031:Hypothalamus / Q000032:analysis; D007124:Immunoenzyme Techniques; D007328:Insulin / Q000032:analysis* / Q000097:blood; D051379:Mice; D009474:Neurons / Q000032:analysis; D010455:Peptides / Q000032:analysis* / Q000097:blood; D011863:Radioimmunoassay; D051381:Rats; D013002:Somatomedins / Q000032:analysis* / Q000097:blood; D013788:Thalamus / Q000032:analysis
D007328:Insulin; D010455:Peptides; D013002:Somatomedins