title: Dietary and metabolic effects on rhesus social behavior: phenylalanine-related dietary alterations.
abstract: Infant rhesus monkeys were (a) fed a diet high in phenylalanine or (b) fed a diet high in p-chlorophenylalanine for the 1st 12 months of life, (c) selected from mothers fed a diet high in phenylalanine during pregnancy, (d) fed a diet low in phenylalanine, (e) maintained as controls, or (f) maintained as pair-fed controls. Tested during the 1st year of life with familiar peers, during the 2nd year with unfamiliar stimulus animals and with a movie film, the 3 groups of phenylketonuric monkeys showed less play and other positive social behavior and more withdrawal and more aggressive behavior than did the 2 control groups. The results support learning data suggesting that phenylketonuric monkeys are more emotionally reactive.
mesh_terms: D000374:Aggression / Q000187:drug effects; D000818:Animals; D005260:Female; D010134:Fenclonine / Q000494:pharmacology*; D000882:Haplorhini; D006801:Humans; D008253:Macaca mulatta; D010649:Phenylalanine / Q000494:pharmacology*; D010661:Phenylketonurias / Q000523:psychology; D010988:Play and Playthings; D011247:Pregnancy; D012919:Social Behavior
chemical_list: D010649:Phenylalanine; D010134:Fenclonine