Biological effects of New Caledonia nickel ore samples on red blood cells, alveolar macrophages and pleural mesothelial cells.
To examine the toxicity of three nickeliferous ores (Noumea Mines, Société le Nickel, in vitro tests were carried out with mammalian cells: haemolysis of human red blood cells (RBC), release of enzymes by rabbit alveolar macrophages (AM) for studying inflammation, and study of rat pleural mesothelial cells (PMC) to determine the effect on cellular growth and genotoxic effects.
D000818:Animals; D001194:Asbestos / Q000009:adverse effects; D002455:Cell Division; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008264:Macrophages / Q000201:enzymology; D009532:Nickel / Q000633:toxicity*; D010994:Pleura / Q000187:drug effects*; D011650:Pulmonary Alveoli / Q000187:drug effects*; D011817:Rabbits; D051381:Rats; D012854:Sister Chromatid Exchange / Q000187:drug effects; D001616:beta-Galactosidase / Q000378:metabolism
D001194:Asbestos; D009532:Nickel; D007770:L-Lactate Dehydrogenase; D001616:beta-Galactosidase