Acetaldehyde influences glucose 1,6-bisphosphate level of human erythrocytes in vitro and in vivo.
In intact erythrocytes from normal adults, acetaldehyde, besides inducing metabolite modifications otherwise observed, markedly decreases the glucose 1,6-bisphosphate (G1,6P2) level. Pyruvate rapidly reverses the acetaldehyde effects. Also in vivo, the acetaldehyde that occurs in the blood stream after heavy alcohol intake produces a significant decrease of the erythrocyte G1,6P2 concentration. These changes support the role of 1,3-bisphosphoglycerate as the first substrate in the G1,6P2 synthesis. The significance of the glucose bisphosphate as glycolytic modulator is also discussed.
D000079:Acetaldehyde / Q000494:pharmacology*; D000244:Adenosine Diphosphate / Q000097:blood; D000255:Adenosine Triphosphate / Q000097:blood; D000328:Adult; D000428:Alcohol Drinking; D004912:Erythrocytes / Q000032:analysis / Q000187:drug effects*; D000431:Ethanol / Q000097:blood; D019298:Glucose-6-Phosphate / Q000031:analogs & derivatives*; D005958:Glucosephosphates / Q000097:blood*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D013696:Temperature
D005958:Glucosephosphates; D000431:Ethanol; D019298:Glucose-6-Phosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; C016473:glucose-1,6-bisphosphate; D000079:Acetaldehyde