Actions and interactions of lipoxygenase and cyclo-oxygenase products in respiratory and vascular tissues.
Actions of leukotrienes (LTs) B4, C4, D4 and E4 were found to be largely mediated via formation of cyclo-oxygenase products in guinea-pig isolated perfused lung and parenchymal strips. In contrast, LTs exerted a direct contractile effect on human isolated parenchymal and bronchial strips. An LT-like substance which had similar biological actions to LTD4 was generated from porcine and guinea-pig vascular tissue. The highest concentration of this material was formed by coronary and pulmonary arteries and the surrounding adventitia, as well as from the lung parenchyma.
D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; D000818:Animals; D001980:Bronchi / Q000201:enzymology; D000001:Calcimycin / Q000494:pharmacology; D002867:Chromones / Q000494:pharmacology; D003331:Coronary Vessels / Q000201:enzymology*; D006168:Guinea Pigs; D006801:Humans; D008084:Lipoxygenase / Q000378:metabolism*; D008168:Lung / Q000201:enzymology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D011651:Pulmonary Artery / Q000201:enzymology*; D011720:Pyrazoles / Q000494:pharmacology; D013189:SRS-A / Q000037:antagonists & inhibitors
D002867:Chromones; D011720:Pyrazoles; D013189:SRS-A; D000001:Calcimycin; D015772:4,5-Dihydro-1-(3-(trifluoromethyl)phenyl)-1H-pyrazol-3-amine; C006312:FPL 55712; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases