title: [Hypotheses on the establishment of a genetic code and transfer of information from proteinoids to nucleic acids].
abstract: An hypothesis is proposed in which the specificity of interaction between an aminoacid and a nucleotide sequence of a tRNA would be enhanced by a ternary association with a specific proteinoid. These strict relations would have led to the present genetic code that we know. It is also proposed that the origin of the enzymatic activity of the primitive proteinoids would have arisen from the presence of different substrates during polymerisation, which would have favored specific sequences of aminoacids by forming more stable complexes with them, corresponding to the lowest free enthalpy. The information included in the aminoacid sequences of the proteinoids would have been transferred to messenger type RNA, according to a mechanism reverse of that for the present process for protein synthesis, and then to DNA.
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D005815:Genetic Code; D008957:Models, Genetic; D009696:Nucleic Acids / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D012333:RNA, Messenger / Q000378:metabolism; D012343:RNA, Transfer / Q000378:metabolism
chemical_list: D000596:Amino Acids; D009696:Nucleic Acids; D011506:Proteins; D012333:RNA, Messenger; D012343:RNA, Transfer
vernacular_title: Hypothèses sur l'établissement d'un code génétique et sur le transfert de l'information des protéinoïdes aux acides nucléiques.