On some mechanisms of antihypoxic actions of nootropic drugs.
The antihypoxic effect of meclofenoxate hydrochloride seen in the accelerated restitution of posthypoxic dopamine release inhibition originates in the alcoholic component of the drug. Via choline dimethylaminoethanol might run, like orotic acid, into a CDP-choline pool, the generation of which is able to be facilitated by piracetam which in turn increases the phosphorylation potential. All these nootropic drugs will in this way increase the biosynthesis of hypoxically vulnerable phospholipids by different mechanisms. Indeed, a combined treatment with piracetam, meclofenoxate hydrochloride and methylglucamineorotate leads to a more rapid restitution of posthypoxic dopamine release inhibition than the drugs are active when applied separately.
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D004347:Drug Interactions; D006016:Glycolates / Q000494:pharmacology*; D000860:Hypoxia / Q000378:metabolism*; D002504:Meclofenoxate / Q000494:pharmacology*; D008536:Meglumine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009963:Orotic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013012:Sorbitol / Q000031:analogs & derivatives*
D006016:Glycolates; D011760:Pyrrolidinones; D013012:Sorbitol; C022100:methylglucamine orotate; D009963:Orotic Acid; D008536:Meglumine; D002504:Meclofenoxate; D004298:Dopamine; D010889:Piracetam