Red blood cells, a source of factors which induce Neisseria gonorrhoeae to resistance to complement-mediated killing by human serum.
Lysates of guinea pig or human red blood cells (RBC) contain far more of the factors that induce resistance in gonococci to complement-mediated killing by fresh human serum that do plasma or serum. As was previously found with serum, most of the resistance-inducing activity of guinea pig RBC lysates was found in ultrafiltrates with molecular weights of less than 5000. In contrast, and as with human serum, most of the resistance-inducing activity of human RBC lysates did not pass ultrafilters which removed molecules of less than 5000 daltons, although some active material of low molecular weight was present.
D000818:Animals; D001770:Blood Bactericidal Activity; D003165:Complement System Proteins / Q000276:immunology; D004912:Erythrocytes / Q000032:analysis* / Q000276:immunology; D006020:Glycopeptides / Q000097:blood* / Q000276:immunology; D006168:Guinea Pigs; D006801:Humans; D008970:Molecular Weight; D009344:Neisseria gonorrhoeae / Q000276:immunology* / Q000472:pathogenicity; D014462:Ultrafiltration
D006020:Glycopeptides; D003165:Complement System Proteins