Genotoxicity of N-nitrosothiazolidine in microbial and hepatocellular test systems.
The genotoxicity of N-nitrosothiazolidine was studied in a microbial system and in a hepatocellular system. The compound showed positive responses in both tests, exhibiting weak mutagenicity at the lowest level tested (1 mg/plate) in the rec assay in Bacillus subtilis, and inducing statistically significant levels of DNA repair in primary hepatocyte cultures at concentrations ranging from 2 X 10(-4) to 2 X 10(-3) M.
D000818:Animals; D001412:Bacillus subtilis / Q000187:drug effects / Q000235:genetics; D004260:DNA Repair / Q000187:drug effects; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D009603:Nitroso Compounds / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013844:Thiazoles / Q000009:adverse effects*
D009153:Mutagens; D009603:Nitroso Compounds; D013844:Thiazoles; C042199:N-nitrosothiazolidine