Fucoidan blocks macrophage activation in an inductive phase but promotes macrophage activation in an effector phase.
It has been suggested that some polysaccharides play important roles in immune responses. Therefore, we used various types of polysaccharides for analysis of macrophage-mediated tumor cell killing. We report here that fucoidan blocked macrophage activation occurs in an inductive phase but enhanced macrophage activation appears in an effector phase.
D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D066298:In Vitro Techniques; D008262:Macrophage Activation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental / Q000276:immunology; D011134:Polysaccharides / Q000494:pharmacology*; D012566:Sizofiran / Q000494:pharmacology
D011134:Polysaccharides; D012566:Sizofiran; C007789:fucoidan