[Therapeutic effectiveness of the transdermal system with nitroglycerin in comparison with nifedipine].
In 12 patients with coronary artery disease 10 cm3 TTS-Nitroderm with 2 X 20 mg Nifedipine were compared. Both substances lowered the number of anginal attacks and the intake of nitroglycerin capsules. Nifedipine pronounced the decrease of afterload as demonstrated by the pressure-rate product. TTS-Nitroglycerin decreased preload and showed a good efficacy. The therapeutic effect was unchanged within the 14 days of observation. By this system the continuous application of nitroglycerin is another therapeutic form of practicable long-term therapy.
D000287:Administration, Topical; D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy; D003327:Coronary Disease / Q000188:drug therapy*; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy; D009543:Nifedipine / Q000008:administration & dosage*; D005996:Nitroglycerin / Q000008:administration & dosage*
D005996:Nitroglycerin; D009543:Nifedipine
Zur therapeutischen Wirksamkeit des transdermalen Systems mit Nitroglycerin im Vergleich zu Nifedipin.