title: Interaction of a streptococcal cell wall tetraheteroglycan and Salmonella telaviv lipopolysaccharide with polymeric McPC 870 and MOPC 384 mouse IgA myeloma proteins.
abstract: Interactions of polymeric McPC 870 and MOPC 384 mouse IgA myeloma proteins with a streptococcal cell wall tetraheteroglycan (T4-antigen), Salmonella tranoroa lipopolysaccharide (LPS), S. telaviv LPS and its lipid A free polysaccharide were examined by the quantitative precipitin method. Hapten inhibition of myeloma protein precipitation by T4-antigen or S. telaviv LPS indicates a complex anticarbohydrate specificity for 870 and 384 protein combining sites involving several sugars. While the combining site of 870 protein appears to bind alpha-D-mannopyranosyl, alpha-D-galactopyranosyl and alpha-D-glucopyranosyl residues, the combining site of 384 protein can accommodate both the alpha (1----2)-linked glucobiose (kojibiose) and alpha-D-galactopyranosyl but not the alpha-D-mannopyranosyl structure.
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D000942:Antigens, Bacterial / Q000276:immunology*; D001666:Binding Sites, Antibody; D002473:Cell Wall / Q000276:immunology; D002850:Chromatography, Gel; D006241:Haptens / Q000276:immunology; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D007070:Immunoglobulin A / Q000276:immunology; D008050:Lipid A; D008070:Lipopolysaccharides / Q000276:immunology*; D051379:Mice; D009194:Myeloma Proteins / Q000276:immunology*; D011233:Precipitin Tests; D012475:Salmonella / Q000276:immunology*; D013291:Streptococcus / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D006241:Haptens; D007070:Immunoglobulin A; D008050:Lipid A; D008070:Lipopolysaccharides; D009194:Myeloma Proteins