title: Thiamphenicol in the treatment of male gonococcal urethritis: a study of 1,230 cases.
abstract: Thiamphenicol, an aminic derivative of hydrocarbilsulfonylpropandiol, was used for the treatment of acute, uncomplicated, gonococcal urethritis in 1,446 male patients. Each patient received one oral dose of 2.5 g of thiamphenicol, which was readministered after 48-72 hr if Neisseria gonorrhoeae continued to be present in urethral smears. Of the 1,446 patients treated, 1,230 patients underwent posttreatment evaluation at 48-72 hrs and at seven days. Twenty-eight patients (2.3%) did not respond to treatment; treatment was successful in 1,140 patients (92.7%) after only one dose, and in 62 (5.0%) after two doses. The overall rate of treatment success was 97.7%. Of 352 patients evaluated one month after treatment, serologic tests in 41 (12.6%) were positive for syphilis.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004341:Drug Evaluation; D005500:Follow-Up Studies; D006069:Gonorrhea / Q000188:drug therapy* / Q000382:microbiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009344:Neisseria gonorrhoeae / Q000302:isolation & purification; D013839:Thiamphenicol / Q000627:therapeutic use*; D014521:Urethra / Q000382:microbiology; D014526:Urethritis / Q000188:drug therapy* / Q000209:etiology
chemical_list: D013839:Thiamphenicol