In vitro susceptibilities of mucoid Pseudomonas aeruginosa isolates from cystic fibrosis patients against azthreonam, netilmicin and piperacillin.
Minimum bacteriostatic (MIC) and bactericidal (MBC) levels were done on 37 clinical isolates of mucoid Pseudomonas aeruginosa from cystic fibrosis patients against azthreonam, netilmicin and piperacillin. Results show that piperacillin had the greatest bacteriostatic activity; however there was more likely to be a significant disparity between MIC and MBC with this drug. Netilmicin was less active than piperacillin, but there was less difference between MICs and MBCs. Azthreonam was the least active compound tested.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001398:Aztreonam; D003550:Cystic Fibrosis / Q000382:microbiology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009428:Netilmicin / Q000494:pharmacology; D010878:Piperacillin / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D009428:Netilmicin; D001398:Aztreonam; D010878:Piperacillin