title: Biological correlates of attachment bond disruption in humans and nonhuman primates.
abstract: Separations or disruptions in attachment bonds occur frequently in the social lives of humans and have been linked to the development of psychopathology. Separation of social nonhuman primates has been proposed as a model to study the psychological and biological effects of separation in humans. This paper reviews the biological alterations that occur in nonhuman primates undergoing separation and compares these with changes associated with separation in humans. The data reviewed demonstrate that separation in humans and nonhuman primates can be an event with profound behavioral and physiological sequelae.
mesh_terms: D000818:Animals; D001010:Anxiety, Separation; D001679:Biogenic Amines / Q000378:metabolism; D001833:Body Temperature Regulation; D001921:Brain / Q000378:metabolism; D002319:Cardiovascular System / Q000503:physiopathology; D003866:Depressive Disorder / Q000503:physiopathology*; D004195:Disease Models, Animal; D005183:Failure to Thrive / Q000503:physiopathology; D006117:Grief; D000882:Haplorhini; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007109:Immunity; D007223:Infant; D009369:Neoplasms / Q000453:epidemiology; D009769:Object Attachment; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D012890:Sleep / Q000502:physiology
chemical_list: D001679:Biogenic Amines