title: Cardiovascular and behavioural changes after i.c.v. infusions of histamine and agonists in conscious goat.
abstract: Histamine (3 and 10 mumoles) raised the blood pressure in the conscious goat when given i.c.v. but lowered it when given intravenously. The results with 2-PEA support the view that central H1-stimulation raises the blood pressure. However, the results with dimaprit do not exclude the participation of central H2-receptors in the effect of histamine on the blood pressure. It appears that in the goat the stimulation of central H1- and H2-receptors mediates opposite actions on behavour. H1-agonist increased and H2-agonist decreased the general activity of the animal.
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D017259:Dimaprit; D005260:Female; D006041:Goats; D006439:Hemodynamics / Q000187:drug effects*; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D011725:Pyridines / Q000494:pharmacology; D011969:Receptors, Histamine H1 / Q000187:drug effects; D011970:Receptors, Histamine H2 / Q000187:drug effects; D013890:Thiourea / Q000494:pharmacology
chemical_list: D011725:Pyridines; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D006632:Histamine; C006183:2-(2-aminoethyl)pyridine; D013890:Thiourea; D017259:Dimaprit