Effects of D-penicillamine on a model of oxygen-derived free radical mediated tissue damage.
In vitro studies indicate that D-penicillamine can affect the depolymerization of hyaluronate in aqueous media (induced primarily by the hydroxyl radical) in several ways. These include: Protecting the hyaluronate by quenching oxygen-derived free radicals (ODFR). Hydrated cupric ions alone and copper(II)-penicillamine complexes were equipotent in quenching ODFR but more potent than D-penicillamine alone. Initiating hyaluronate degradation by (a) directly reducing inert Fe(III) to reactive Fe(II) (which may autoxidize to produce hydroxyl radicals), a property shared with other thiols, and (b) forming reactive iron complexes that catalyse the formation of hydroxyl radicals from superoxide and hydrogen peroxide.
D002374:Catalase / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D003300:Copper; D004492:Edetic Acid / Q000494:pharmacology; D005609:Free Radicals; D006820:Hyaluronic Acid / Q000378:metabolism*; D007700:Kinetics; D010084:Oxidation-Reduction; D010396:Penicillamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000378:metabolism; D014783:Viscosity
D005609:Free Radicals; D013438:Sulfhydryl Compounds; D003300:Copper; D006820:Hyaluronic Acid; D004492:Edetic Acid; D002374:Catalase; D013482:Superoxide Dismutase; D010396:Penicillamine