Hypothalamic mass and gigantism in neurofibromatosis: treatment with bromocriptine.
A child with neurofibromatosis exhibited gigantism and acromegaly in association with a hypothalamic mass lesion. Bromocriptine, 5 mg daily, reduced somatic growth rate and restored biochemical homeostasis but had no effect on tumor growth. Radiation therapy arrested tumor enlargement and stabilized deteriorating visual function.
D000172:Acromegaly / Q000188:drug therapy / Q000209:etiology*; D001971:Bromocriptine / Q000627:therapeutic use*; D002675:Child, Preschool; D005260:Female; D005877:Gigantism / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D007029:Hypothalamic Neoplasms / Q000150:complications* / Q000532:radiotherapy; D009456:Neurofibromatosis 1 / Q000150:complications*
D001971:Bromocriptine