title: Stereospecific binding capacity of proteins on surfaces--simple mathematical models.
abstract: The adsorption of and interaction between protein molecules on solid surfaces are phenomena involved in many situations of biochemical and physical interest. This communication is an attempt to relate stoichiometrically substances binding to each other on surfaces. One experimental observation, which we try to explain, is that the maximum antibody binding capacity of an antigen covered surface does not always occur at the largest coverage of antigens.
mesh_terms: D000327:Adsorption; D000937:Antigen-Antibody Reactions; D001666:Binding Sites, Antibody; D003166:Complement Activating Enzymes / Q000378:metabolism; D015922:Complement C1q; D006801:Humans; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000378:metabolism; D008433:Mathematics; D008956:Models, Chemical; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism; D012709:Serum Albumin / Q000276:immunology
chemical_list: D007074:Immunoglobulin G; D011506:Proteins; D012709:Serum Albumin; D015922:Complement C1q; D003166:Complement Activating Enzymes