Effect of pretreatment with hydroxylated xenobiotics on the activities of rat liver UDP-glucuronosyl-transferases.
Six hydroxylated substrates were examined as potential inducers of UDP-glucuronosyltransferases towards their conjugation and the conjugation of other 'model' aglycones with glucuronic acid. Time-dependence (4, 14 and 28 days) and dose-dependence of treatments (from 25 mg/kg to 1 g/kg) were examined for some of these compounds. Monoterpenoid alcohols (borneol and terpineol) did not enhance the glucuronidation of the ten substrates tested. p-Hydroxybiphenyl gives typical 'substrate-induction' towards its own conjugation. Eugenol, a previously described inducer of UDP-glucuronosyltransferase activities in mouse, and 4-methylumbelliferone, give a general enhancement of all activities tested, especially those of the '3-methylcholanthrene-inducible' group of aglycones. p-Nitrophenol at low dose (2.5 mg/kg) gives a limited 'polycyclic aromatic hydrocarbon'-like increase.
D000818:Animals; D001711:Biotransformation / Q000187:drug effects*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D005054:Eugenol / Q000494:pharmacology*; D014453:Glucuronosyltransferase / Q000096:biosynthesis / Q000378:metabolism*; D006923:Hymecromone / Q000494:pharmacology*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D013729:Terpenes / Q000494:pharmacology*; D014468:Umbelliferones / Q000494:pharmacology*
D001713:Biphenyl Compounds; D013729:Terpenes; D014468:Umbelliferones; D006923:Hymecromone; D005054:Eugenol; C019046:4-phenylphenol; D014453:Glucuronosyltransferase