title: Transcriptional induction of two genes in human cells by beta interferon.
abstract: The binding of interferons to distinct cell surface receptors leads to the induction of synthesis of several unique polypeptides and their corresponding mRNAs (1-6). We have isolated two cDNAs that are complementary to nuclear RNA whose synthesis is induced from undetectable levels to maximal rates of transcription within 30-60 min after the addition of beta interferon to human fibroblasts or to HeLa cells. These results prove that a single polypeptide can, by binding to a specific plasma membrane receptor, promptly activate the transcription of a defined set of genes.
mesh_terms: D004247:DNA; D004274:DNA, Recombinant; D005347:Fibroblasts / Q000378:metabolism; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology; D009693:Nucleic Acid Hybridization; D014176:Protein Biosynthesis; D012319:RNA Polymerase II / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis*; D014158:Transcription, Genetic
chemical_list: D004274:DNA, Recombinant; D007370:Interferon Type I; D012333:RNA, Messenger; D007371:Interferon-gamma; D004247:DNA; D012319:RNA Polymerase II