[Effect of disseminated myocardial necrosis on ATPase activity, Ca2+ transport, and lipid peroxidation in cardiac mitochondrial and microsomal membranes].
Isoproterenol-induced (5 mg/kg) disseminated necrosis of the rabbit myocardium led to a decrease in the efficiency of calcium pump of sarcoplasmic reticulum fragments. This was shown by the reduced Ca/ATP ratio, as well as by Ca2+ and Ca2+ ATPase accumulation rate. In these conditions, calcium transport to mitochondria increased. Lipid peroxidation plays a definite role in the impairment of membrane permeability since the concentration of malonic dialdehyde rises in microsomal and mitochondrial fractions.U
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D009202:Cardiomyopathies / Q000139:chemically induced / Q000378:metabolism*; D004140:Dinitrophenols / Q000494:pharmacology; D007545:Isoproterenol; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008274:Magnesium / Q000494:pharmacology; D008861:Microsomes / Q000378:metabolism; D008929:Mitochondria, Heart / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D009336:Necrosis; D011817:Rabbits
D004140:Dinitrophenols; D008054:Lipid Peroxides; D000251:Adenosine Triphosphatases; D008274:Magnesium; D007545:Isoproterenol; D002118:Calcium
Vliianie rasseiannogo nekroza miokarda na ATF-aznuiu aktivnost', transport Ca2+ i perekisnoe okislenie lipidov membran mitokhondriĭ i mikrosom serdtsa.