Effect of a single brief seizure on subsequent seizure susceptibility in the immature rat.
To determine whether a single seizure permanently affects the brain's susceptibility to further seizures, 27-day-old rats were subjected to a single seizure induced by either an electroshock or the administration of pentylenetetrazol. Three days following the seizure, the rats, along with age- and weight-matched control rats, underwent kindling. The rate of kindling did not differ between the control rats and those rats that had previously experienced a single electroshock or pentylenetetrazol-induced seizure. At the present time, there is no conclusive evidence that a single brief seizure results in permanently increased susceptibility to future convulsions.
D000818:Animals; D004198:Disease Susceptibility / Q000503:physiopathology*; D004597:Electroshock; D004831:Epilepsies, Myoclonic / Q000503:physiopathology*; D004828:Epilepsies, Partial / Q000503:physiopathology*; D004827:Epilepsy / Q000139:chemically induced; D005260:Female; D007696:Kindling, Neurologic; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D011919:Rats, Inbred Strains
D010433:Pentylenetetrazole