Antitumor activity in the culture supernatant fluid of Fusobacterium nucleatum strain KO-31.
Antitumor activity of Fusobacterium nucleatum strain KO-31, which had been isolated from the oral cavity, was investigated in Ehrlich carcinoma-bearing mice. The strain KO-31 was cultured in TF medium for 48 hr. One-half ml of the culture supernatant fluid was injected intraperitoneally during a 7-day period to mice with Ehrlich ascites carcinoma. The survival time of the treated mice prolonged remarkably. A significant reduction in size of the solid Ehrlich tumor was also achieved with the supernatant. Antitumor activity was not observed in the cell extract.
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000627:therapeutic use; D001835:Body Weight / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D003470:Culture Media / Q000032:analysis; D005260:Female; D005673:Fusobacterium / Q000378:metabolism*; D006358:Hot Temperature; D051379:Mice; D008813:Mice, Inbred ICR; D016685:Mitomycin; D008937:Mitomycins / Q000627:therapeutic use
D000970:Antineoplastic Agents; D003470:Culture Media; D008937:Mitomycins; D016685:Mitomycin