[Comparative electron microscopic study of spontaneous and DMBA-induced tumors of mouse mammary glands].
The ultrastructural peculiarities of spontaneous and DMBA induced breast tumours in C3H/He and C3H/Sn mice are described. It is shown that spontaneous breast tumours in mice are highly differentiated adenocarcinomas arisen from acinus against a background of alveolar hyperplasia. DMBA induced breast tumours in mice develop with transformation of ductule-epithelial population of cells. The content and distribution of virus particles are different in spontaneous and DMBA induced breast tumours. The possible transformation of myoepithelial cells is suggested.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000230:Adenocarcinoma / Q000139:chemically induced / Q000648:ultrastructure*; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000648:ultrastructure*; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000648:ultrastructure*; D051379:Mice; D008809:Mice, Inbred C3H; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure
D015127:9,10-Dimethyl-1,2-benzanthracene
Sravnitel'noe élektronno-mikroskopicheskoe issledovanie spontannykh i indutsirovannykh DMBA opukholeĭ molochnykh zhelez mysheĭ.