title: The effect of chemotherapy on lymphocyte subpopulations and cell-mediated cytotoxicity in patients with ovarian carcinoma.
abstract: Chemotherapy using adriamycin with cyclophosphamide, and cyclophosphamide with hexamethylmelamine or with alkeran causes no significant reduction in the total lymphocyte count, in the percentage subpopulations of T cells and B cells or in mononuclear cell cytotoxicity in patients with Stage II carcinoma of the ovary during their first course of chemotherapy.
mesh_terms: D006585:Altretamine / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001402:B-Lymphocytes / Q000187:drug effects; D003520:Cyclophosphamide / Q000008:administration & dosage; D003601:Cytotoxicity Tests, Immunologic; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008214:Lymphocytes / Q000187:drug effects*; D008558:Melphalan / Q000627:therapeutic use; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000601:surgery; D013601:T-Lymphocytes / Q000187:drug effects; D013997:Time Factors
chemical_list: D004317:Doxorubicin; D003520:Cyclophosphamide; D008558:Melphalan; D006585:Altretamine