Suppressor cells in specific unresponsiveness to skin allografts in ALS-treated, marrow-injected mice.
Lymphoid cells from ALS-treated (C57BL/6 x A/J)F1 (B6AF1) mice bearing enhanced C3H/He grafts were assayed for their ability to suppress the response to C3H/He grafts after transfer to syngeneic B6AF1 recipients. Cells were transferred from ALS-treated B6AF1 mice that had received either a C3H/He graft alone, C3H/He marrow alone, or both a graft and marrow. Suppressor cells appeared in the spleens of ALS-treated B6AF1 mice that had received either a graft alone or both graft and marrow as early as day +13. They persisted only in the spleens of mice that had received both a graft and marrow, i.e., mice whose grafts showed significant prolongation. Suppressor cells did not appear in the lymph nodes of mice bearing enhanced grafts until day +42. Thymocytes and bone marrow cells were unable to transfer unresponsiveness. The cells which transferred unresponsiveness were specific for the graft donor strain as they did not transfer unresponsiveness to third-party grafts. The ability of cells to transfer suppression was abrogated by treatment with anti-theta serum.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology*; D001853:Bone Marrow / Q000276:immunology; D016026:Bone Marrow Transplantation; D006085:Graft Survival; D007156:Immunologic Memory; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D016038:Skin Transplantation; D013154:Spleen / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology; D014184:Transplantation, Homologous
D000961:Antilymphocyte Serum