Augmentation of natural cell-mediated cytotoxic reactivity of mouse lymphoid cells by aloctin A.
The levels of natural cell-mediated cytotoxicity could be augmented by administration of Aloctin A (Alo A), a lectin having anti-tumor activity. i.v. administration of Alo A induced augmentation of cytotoxicity by spleen cells and by peritoneal exudate cells (PEC). On the other hand, i.p. administration of Alo A induced augmentation of cytotoxicity by PEC but not by spleen cells. The effector cells seemed to be natural killer cells.
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002460:Cell Line; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D005260:Female; D007694:Killer Cells, Natural / Q000187:drug effects*; D037102:Lectins / Q000494:pharmacology*; D007942:Leukemia, Experimental; D008223:Lymphoma; D012515:Mast-Cell Sarcoma; D051379:Mice; D008807:Mice, Inbred BALB C; D008979:Moloney murine leukemia virus; D037121:Plant Lectins; D012513:Sarcoma, Experimental; D013154:Spleen / Q000166:cytology
D000972:Antineoplastic Agents, Phytogenic; D037102:Lectins; D037121:Plant Lectins; C033193:aloctin A