Osteogenic activity of antibiotic-supplemented bone allografts in the guinea pig.
This study evaluated the osteogenic potential of bone allografts supplemented with up to 1000 times the minimum inhibitory concentration of cephalothin and tobramycin effective against Staphylococcus aureus and Pseudomonas aureus. Mineralized and demineralized bone allografts with and without antibiotics were compared in calvarial defects of guinea pigs. Strontium-85 uptake and histologic evaluation indicated there was no significant difference in osteogeneic activity between nonantibiotic-supplemented allografts and antibiotic-supplemented allografts.
D000818:Animals; D016025:Bone Transplantation; D001842:Bone and Bones / Q000033:anatomy & histology / Q000502:physiology; D002512:Cephalothin / Q000008:administration & dosage* / Q000494:pharmacology; D003648:Decalcification Technique; D006168:Guinea Pigs; D007085:Ilium / Q000601:surgery; D008297:Male; D010012:Osteogenesis / Q000187:drug effects; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012886:Skull / Q000601:surgery; D013211:Staphylococcus aureus / Q000187:drug effects; D014031:Tobramycin / Q000008:administration & dosage* / Q000494:pharmacology
D002512:Cephalothin; D014031:Tobramycin