Effect of doxepin on gastric secretion in man.
The effect of doxepin, a tricyclic antidepressive agent, on gastric secretion of acid and pepsin was studied in five healthy students. Dose-response studies were carried out on different days with increasing doses of doxepin on a constant background stimulation with pentagastrin and with increasing doses of pentagastrin in combination with a constant dose of doxepin. Doxepin reduced gastric acid secretion when serum values of doxepin were above 60 nmol/l.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004316:Doxepin / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D010434:Pepsin A / Q000378:metabolism; D012636:Secretory Rate / Q000187:drug effects
D004316:Doxepin; D010434:Pepsin A; D010418:Pentagastrin