title: [Peripheral venous tolerance of a hyperosmolar basic solution].
abstract: A controlled open clinical trial was carried out to compare the peripheral venous tolerance of patients receiving a hyperosmolar basic nutrition solution (3% amino acids, carbohydrates and electrolytes, 806 mosm/l) with that of patients receiving an isoosmolar electrolyte solution (299 mosm/l). 13 patients received the basic solution, 11 the electrolyte solution. The study was terminated after 4 days. For comparison the infusion time and local venous irritation of each patient were recorded. In both the infusion time and local irritation a slight trend in favour of the electrolyte solution was found, which, however, did not reach statistical significance. We conclude, that under normal clinical circumstances a hyperosmolar basic nutrition solution does not cause a higher rate of peripheral venous irritations compared with an isoosmolar electrolyte solution and should be administered to patients with an expected infusion time of not longer than 4 days.
mesh_terms: D000596:Amino Acids / Q000009:adverse effects; D002241:Carbohydrates / Q000009:adverse effects; D004573:Electrolytes / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009994:Osmolar Concentration; D010288:Parenteral Nutrition / Q000009:adverse effects*; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D014680:Veins / Q000187:drug effects
chemical_list: D000596:Amino Acids; D002241:Carbohydrates; D004573:Electrolytes
vernacular_title: Zur Frage der peripheren Venenverträglichkeit einer hyperosmolaren Basislösung.