[The influence of arterial partial pressure of CO2 and of the arterial value of pH on the oxygen consumption of the whole body during extracorporal circulation (author's transl)].
134 patients with coronary heart disease, with defects of the cardiac values or with inborn heart diseases were studied referring to the influences of the arterial partial pressure of CO2 and the arterial value of pH on oxygen consumption of the whole body during total hypothermic extracorporal circulation. Oxygen consumption of the whole body increases during respiratory or metabolic alkalosis whereas respiratory or metabolic acidosis decreases oxygen consumption significantly. These typical changes of oxygen consumption of the whole body during extraorporal circulation due to alkalosis or acidosis may be explained by different facts. Within the cellular area glycolysis is in relation of value for pH, and phosphofructokinase-reaction slows up due to ATP-level also in relationship of value for pH. In addition to cellular parameters hemodynamic parameters may explain the changes of oxygen consumption due to alkalosis and acidosis. Alkalosis effects a decrease of the total peripheral resistane whereas acidosis effects an increase of the total peripheral resistance. Peripheral oxygen consumption vaires in addition to other parameters in inverse proportion of the level of totalperipheral resistance.
D000136:Acid-Base Equilibrium; D000138:Acidosis / Q000201:enzymology; D000293:Adolescent; D000328:Adult; D000368:Aged; D000471:Alkalosis / Q000201:enzymology; D001810:Blood Volume; D002245:Carbon Dioxide / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005112:Extracorporeal Circulation; D005260:Female; D006019:Glycolysis; D006331:Heart Diseases / Q000201:enzymology / Q000601:surgery; D006801:Humans; D007036:Hypothermia, Induced; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood*; D010732:Phosphofructokinase-1 / Q000097:blood
D002245:Carbon Dioxide; D010732:Phosphofructokinase-1; D010100:Oxygen
Der Einfluss der arteriellen Kohlensäurespannung und des arteriellen pH-Wertes auf den Sauerstoffverbrauch des Gesamtorganismus während der extrakorporalen Zirkulation.