[Effect of androgens on the growth of skin fibroblasts in culture].
The effect of DHT on skin fibroblasts proliferation was investigated by measurements of DNA concentrations and of 3H-thymidine incorporation variations. 1 nM DHT did not stimulate fibroblasts growth in either genital nor non genital skin fibroblasts. At higher concentrations, DHT inhibited cell proliferation. It can be concluded that in cell culture, fibroblasts growth is not dependent from androgen receptor content.
D000328:Adult; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D013196:Dihydrotestosterone / Q000494:pharmacology*; D005333:Fetus; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D012867:Skin / Q000166:cytology* / Q000187:drug effects
D013196:Dihydrotestosterone
Action des androgènes sur la croissance des fibroblastes cutanés en culture.