Effects of cryoglobulin on fibrin clot formation and fibrinolysis.
It was confirmed that activation of the kallikrein-kinin enzyme system in cryoglobulinemia might be initiated by activation of factor XII to factor XIIa by cryoglobulin. It was also demonstrated that cryoglobulin or fibrin clots lost their ability to redissolve on warming to 37 degrees C, and consequently the lysis time of fibrin clots was increased.
D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D003450:Cryoglobulins / Q000378:metabolism / Q000502:physiology*; D005174:Factor XII / Q000378:metabolism; D005337:Fibrin / Q000378:metabolism*; D005342:Fibrinolysis; D006801:Humans; D012712:Serum Globulins / Q000378:metabolism; D012995:Solubility
D003450:Cryoglobulins; D012712:Serum Globulins; D005174:Factor XII; D005337:Fibrin