Pharmacokinetics of valpromide after oral administration of a solution and a tablet to healthy volunteers.
The pharmacokinetics of valpromide, a primary amide of valproic acid, was investigated in 6 healthy, adult male volunteers, each of whom was given 900 mg as a marketed, enteric-coated tablet and a solution. Valpromide was biotransformed to valproic acid after the administration of the tablet and the solution with a bioavailability of 0.79 +/- 0.24 and 0.77 +/- 0.12, respectively, relative to a marketed tablet of valproic acid. The absorption of valpromide was not rate-limited by dissolution. As a solid, nonhygroscopic, neutral prodrug of valproic acid, valpromide may be a good alternative to valproic acid and sodium valproate.
D000328:Adult; D006801:Humans; D007700:Kinetics; D008297:Male; D012996:Solutions; D013607:Tablets; D013997:Time Factors; D014635:Valproic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism*
D012996:Solutions; D013607:Tablets; D014635:Valproic Acid; C004651:dipropylacetamide