Effect of pentoxifylline ('Trental') on cochlear blood flow as measured by hydrogen wash-out.
A comparative experimental study was carried out in guinea-pigs to assess the effect of pentoxifylline on inner ear perfusion. Five animals were given a single dose of 30 mg pentoxifylline per 10-minute intravenous infusion and the cochlear blood flow measured by means of the hydrogen-clearance technique before and after administration of the drug. A control group of 11 animals received the solvent only. Compared to controls, a significant increase in inner ear blood flow was observed in the pentoxifylline-treated animals. These data may explain positive clinical findings with pentoxifylline in otological disorders associated with impaired cochlear perfusion.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D003051:Cochlea / Q000098:blood supply*; D005260:Female; D006168:Guinea Pigs; D006207:Half-Life; D006859:Hydrogen; D006863:Hydrogen-Ion Concentration; D008297:Male; D010431:Pentoxifylline / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects; D013805:Theobromine / Q000031:analogs & derivatives*
D002245:Carbon Dioxide; D006859:Hydrogen; D013805:Theobromine; D010431:Pentoxifylline