Short-term action of streptozotocin on biochemical activity and morphology of the rat liver golgi apparatus.
After six hours, the diabetogenic dose of streptozotocin has neither induced the release of hepatocyte cytoplasmic enzyme nor visibly injured the hepatocyte. As a rule, however, these doses of streptozotocin induced various responses in individual rat livers. Morphological studies have shown hypertrophy of the rat liver Golgi apparatus, higher numbers of secretory vacuoles and dilated cisternae. After this time liver Golgi-rich fractions revealed increased total liver galactosyl transferase activity and higher level but unaltered electrophoretical patterns of protein.
D000409:Alanine; D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001224:Aspartic Acid; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005958:Glucosephosphates; D006056:Golgi Apparatus / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007773:Lactates; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D013311:Streptozocin / Q000008:administration & dosage / Q000494:pharmacology*
D005958:Glucosephosphates; D007773:Lactates; D001224:Aspartic Acid; D013311:Streptozocin; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000409:Alanine