title: [S-adenosyl-L-homocysteine: 1. Influence on sleep].
abstract: S-Adenosylhomocysteine, 0.1-20 mg/kg, influences the sleep patterns of rat, cat and rabbit by increasing the slow-wave and fast-wave sleep for 6 h. The SAH effects are increased by p-chlorophenylalanine and iproniazid and unchanged by reserpine. SAH effects are correlated with modification of norepinephrine and serotonin metabolism.
mesh_terms: D000818:Animals; D002415:Cats; D004357:Drug Synergism; D005260:Female; D010134:Fenclonine / Q000494:pharmacology; D006710:Homocysteine / Q000031:analogs & derivatives*; D007490:Iproniazid / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D012435:S-Adenosylhomocysteine / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism; D012890:Sleep / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects; D013997:Time Factors
chemical_list: D006710:Homocysteine; D012701:Serotonin; D012110:Reserpine; D012435:S-Adenosylhomocysteine; D007490:Iproniazid; D010134:Fenclonine; D009638:Norepinephrine
vernacular_title: La S-adénosyl-L-homocystéine: 1. Inductrice de sommeil.