Pre-atherosclerotic lesions in Down syndrome.
Autopsy examination of seven non-institutionalised Down syndrome patients (age ten to twenty-five years) revealed normal prevalence of pre-atherosclerotic lesions. Atherosclerotic plaques were observed in one of these subjects (age fourteen years), refuting reported implications that this population is atheroma-free. However, atheromatous aortic lesions were not seen in an eighth subject (age fifty years), raising the possibility that an atheroma-free subgroup of patients with Down syndrome may exist.
D000293:Adolescent; D000328:Adult; D001012:Aorta, Abdominal / Q000473:pathology; D001161:Arteriosclerosis / Q000473:pathology*; D002648:Child; D004314:Down Syndrome / Q000473:pathology*; D005260:Female; D005352:Fibromuscular Dysplasia / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged