[Multiplication of Mycobacterium tuberculosis in the organs of mice with a single exposure to cyclophosphamide].
The injection of cyclophosphamide, used as an immunomodulating agent in a dose of 100 mg/kg, into mice infected with M. tuberculosis induced an increase (a virulent culture) or a decrease (a culture with low virulence) in the multiplication of mycobacteria in the spleen. In mice infected with a virulent culture and protected from infection with streptomycin for 1 week cyclophosphamide induced a considerable decrease in the number of viable mycobacteria in the lungs by days 18-20 after infection.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009169:Mycobacterium tuberculosis / Q000187:drug effects* / Q000502:physiology; D013307:Streptomycin / Q000008:administration & dosage; D013997:Time Factors; D014376:Tuberculosis / Q000188:drug therapy* / Q000382:microbiology; D014774:Virulence / Q000187:drug effects
D000276:Adjuvants, Immunologic; D003520:Cyclophosphamide; D013307:Streptomycin
Razmnozhenie mikobakteriĭ tuberkuleza v organakh mysheĭ pri odnokratnom vozdeĭstvii tsiklofosfamidom.