L-deprenyl plus L-phenylalanine in the treatment of depression.
The antidepressive efficacy of 1-deprenyl (5-10 mg daily) plus 1-phenylalanine (250 mg/day) has been evaluated in 155 unipolar depressed patients. Both oral and intravenous administration showed beneficial effects in 90% of outpatients and 80.5% of inpatients. It is concluded that this combined treatment has a potent antidepressive action based on the accumulation of 1-phenylethylamine in the brain.
D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D010627:Phenethylamines / Q000627:therapeutic use*; D010649:Phenylalanine / Q000008:administration & dosage / Q000627:therapeutic use*; D012642:Selegiline / Q000008:administration & dosage / Q000627:therapeutic use*
D010627:Phenethylamines; D012642:Selegiline; D010649:Phenylalanine