title: Physiology of resuscitation.
abstract: Ischemia ultimately leads to loss of thermodynamic order in all cells. During ischemia and reperfusion, the influx of Ca2+ ions appears to initiate a number of cell processes, the reversal of which depends on the re-establishment and maintenance of adequate organ perfusion and high energy metabolism. Promising therapeutic approaches for accomplishing these goals include substrate augmentation, inhibition of calcium-activated injury, membrane stabilization, manipulation of the cycloxygenase and lipoxygenase reactions, and the use of free radical scavengers.
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001775:Blood Circulation; D002118:Calcium / Q000378:metabolism / Q000502:physiology; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D002470:Cell Survival; D004285:Dogs; D004632:Emergency Medical Services; D004734:Energy Metabolism; D005609:Free Radicals; D006323:Heart Arrest / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007511:Ischemia / Q000378:metabolism* / Q000503:physiopathology / Q000628:therapy; D008084:Lipoxygenase / Q000378:metabolism / Q000502:physiology; D008928:Mitochondria / Q000378:metabolism; D010100:Oxygen / Q000502:physiology; D010101:Oxygen Consumption; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism / Q000502:physiology; D011453:Prostaglandins / Q000378:metabolism / Q000502:physiology; D011817:Rabbits; D051381:Rats; D012151:Resuscitation
chemical_list: D002121:Calcium Channel Blockers; D005609:Free Radicals; D011453:Prostaglandins; D000255:Adenosine Triphosphate; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases; D010100:Oxygen; D002118:Calcium