Lithium-induced accentuation of extrapyramidal symptoms in individuals with Alzheimer's disease.
Lithium treatment in 9 elderly individuals with Alzheimer's disease led to a marked accentuation of extra-pyramidal symptoms (EPS) in 5 of 6 patients with preexisting EPS. EPS scores significantly correlated with plasma and RBC lithium levels. Lithium treatment had no such effects in the 3 patients without preexisting extrapyramidal symptoms.
D000208:Acute Disease; D000368:Aged; D000544:Alzheimer Disease / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D001480:Basal Ganglia Diseases / Q000097:blood / Q000139:chemically induced* / Q000150:complications; D004912:Erythrocytes / Q000032:analysis; D005260:Female; D006801:Humans; D008094:Lithium / Q000009:adverse effects* / Q000097:blood; D016651:Lithium Carbonate; D008297:Male; D008875:Middle Aged
D016651:Lithium Carbonate; D008094:Lithium