The effect of oestrogen (mestranol) on the thyrotrophin response to thyrotrophin releasing hormone in postmenopausal oophorectomised women.
The thyrotrophin (TSH) responses to thyrotrophin releasing hormone (TRH) in 16 oophorectomised postmenopausal women on long term treatment with mestranol 24 micrograms daily were compared to those in 16 oophorectomised postmenopausal women on placebo treatment. No significant difference between the groups was found in either basal TSH levels or the TSH response to TRH. It is therefore unlikely that the difference in TSH response to TRH between men and women of reproductive age is due to a direct stimulatory effect of oestrogen in women.
D002369:Castration; D005260:Female; D006801:Humans; D008593:Menopause; D008656:Mestranol / Q000627:therapeutic use*; D008875:Middle Aged; D010024:Osteoporosis / Q000517:prevention & control; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D008656:Mestranol