[Anti-tumor effects of adriamycin, 4'-Epi-adriamycin, THP-adriamycin and mitoxantrone on rat mammary cancer induced by 7,12-dimethyl benz (A) anthracene].
Comparative studies of the anti-tumor effects of Adriamycin, 4'-Epi-Adriamycin, THP-Adriamycin and Mitoxantrone on rat mammary cancer induced by 7, 12-DMBA were performed. All 4 drugs were effective on the tumors, three administrations of Adriamycin, 4'-Epi-Adriamycin or Mitoxantrone at 1-week intervals showed remarkable tumor regression in each group. Mitoxantrone was not so effective in comparison with the other 3 drugs. Decrease in the body weight of the rats was most remarkably observed in the Mitoxantrone-treated group.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000880:Anthraquinones / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D008942:Mitoxantrone; D051381:Rats; D011919:Rats, Inbred Strains
D000880:Anthraquinones; D000970:Antineoplastic Agents; D015127:9,10-Dimethyl-1,2-benzanthracene; D004317:Doxorubicin; D008942:Mitoxantrone; C027260:pirarubicin