Novel mode of cytotoxicity obtained by coupling inactive anthracycline to a polymer.
The inactive anthracycline analog 4-demethoxy-7,9-di-epi-daunorubicin was covalently coupled to polyglutaraldehyde microspheres. The polymer-bound analog acquired significant cytostatic activity as evaluated with doxorubicin resistant and sensitive murine L1210 leukemia cells. A suggested multiple membrane interaction at the cell surface may represent a novel mechanism of cytotoxicity.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000008:administration & dosage*; D003630:Daunorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005976:Glutaral / Q000008:administration & dosage; D015255:Idarubicin; D007939:Leukemia L1210 / Q000188:drug therapy; D008863:Microspheres; D011108:Polymers / Q000008:administration & dosage*
D000903:Antibiotics, Antineoplastic; D011108:Polymers; D005976:Glutaral; D015255:Idarubicin; D003630:Daunorubicin