A haemodynamic and pharmacokinetic study to assess a new transdermal nitroglycerin preparation in normal subjects.
A continual application of a transdermal Nitroglycerin ( Nitrodur ) has been haemodynamically and pharmacokinetically assessed in a group of 10 normal healthy volunteers over a 24 h period. There were significant decreases in left ventricular end systolic dimension and end diastolic dimension over this period, demonstrating a continuous haemodynamic effect. A dose related response was not demonstrated, although low plasma nitroglycerin levels produced significant haemodynamic changes. The persistent decrease in left ventricular wall stress implies a reduction in myocardial oxygen consumption. Thus Nitrodur may play an important role in the long term prophylaxis of angina.
D000328:Adult; D002302:Cardiac Output / Q000187:drug effects; D004452:Echocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007271:Injections, Intradermal; D007700:Kinetics; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D005996:Nitroglycerin / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology*; D013318:Stroke Volume / Q000187:drug effects
D005996:Nitroglycerin