Rifampicin-erythromycin combination for the treatment of gonococcal urethritis in men.
A total of 184 men with uncomplicated gonococcal urethritis were treated with a single oral dose of rifampicin 900 mg and erythromycin stearate 1 gm. The cure rate on day 3 was 95.1%, 175 were cured and 9 failed (4.9%). Of all the Neisseria gonorrhoeae isolated, 86 were PPNG (46.7%). There was no difference in failure rate among patients with PPNG or with non-PPNG. With the exception of self-limited gastrointestinal disturbance, side effects were minimal. The value of this combination for the treatment of uncomplicated gonococcal urethritis in men is promising and deserves further study.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003365:Costs and Cost Analysis; D004359:Drug Therapy, Combination; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D010403:Penicillin Resistance; D011339:Probenecid / Q000627:therapeutic use; D012293:Rifampin / Q000627:therapeutic use*; D013785:Thailand; D014526:Urethritis / Q000188:drug therapy*
D004917:Erythromycin; D000667:Ampicillin; C011462:erythromycin stearate; D011339:Probenecid; D012293:Rifampin