title: Monoclonal IgM-secreting neoplasms. Clinical and morphologic heterogeneity.
abstract: Two patients with monoclonal IgM-secreting neoplasms are presented. Though both patients could be diagnosed as Waldenström's macroglobulinemia, the clinicopathologic features were quite contrastive. Most neoplastic cells in Case 1 showed lymphocytic morphology with rather leukemic process, while those in Case 2 were highly polymorphic with solid proliferation. The clinical and morphologic heterogeneity in these cases and cases in the literature is discussed, and the possible requirement to establish a system for the subclassification of IgM-secreting neoplasms is insisted.
mesh_terms: D000911:Antibodies, Monoclonal; D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism*; D008099:Liver / Q000473:pathology; D008214:Lymphocytes / Q000648:ultrastructure; D008221:Lymphoid Tissue / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009369:Neoplasms / Q000378:metabolism*; D013154:Spleen / Q000473:pathology; D008258:Waldenstrom Macroglobulinemia / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D007075:Immunoglobulin M