Nature of the reversible white matter lesion in multiple sclerosis. Effects of acute inflammation on myelinated tissue studied in the rabbit eye.
Arthus reactions of different intensities were induced in the rabbit eye using measles vaccine as the immunogen. In the presence of a mild Arthus reaction in the vitreous, myelinated nerve fibre bundles on the retinal surface revealed extracellular oedema together with marked swelling and rupture of astrocyte processes, including those bearing a special relationship to nodes of Ranvier. These changes improved or disappeared over the course of six days. No demyelination occurred. The findings implicate an astrocytic lesion as a possible cause of reversible neurological deficit and conduction block associated with acute inflammation in central white matter.
D000818:Animals; D001183:Arthus Reaction / Q000473:pathology; D001253:Astrocytes / Q000473:pathology; D001921:Brain / Q000473:pathology; D005123:Eye / Q000473:pathology*; D005260:Female; D007249:Inflammation / Q000473:pathology; D008297:Male; D008458:Measles Vaccine; D009103:Multiple Sclerosis / Q000473:pathology*; D009413:Nerve Fibers, Myelinated / Q000473:pathology*; D011817:Rabbits; D012160:Retina / Q000294:innervation
D008458:Measles Vaccine