The effects of various antiepileptic drugs on E-shock-induced amnesia in mice: dissociability of effects on convulsions and effects on memory.
Antiepileptic drugs prevent tonic convulsions induced by cerebral electroshocks. The present study investigated whether these drugs can also modulate the amnestic effect of the cerebral electroshock. It could be shown that phenytoin, ethosuximide, valproinate sodium, phenobarbitone, and clonazepam dose-dependently worsened the amnestic effect of electroshock (despite prevention of the convulsion). Carbamazepine, in contrast, significantly reduced the amnestic effect of the cerebral electroshock even at doses below the threshold for anticonvulsant activity.
D000647:Amnesia / Q000517:prevention & control*; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use; D002998:Clonazepam / Q000627:therapeutic use; D004597:Electroshock; D005013:Ethosuximide / Q000627:therapeutic use; D006801:Humans; D008297:Male; D051379:Mice; D010634:Phenobarbital / Q000627:therapeutic use; D010672:Phenytoin / Q000627:therapeutic use; D014635:Valproic Acid / Q000627:therapeutic use
D000927:Anticonvulsants; D002220:Carbamazepine; D002998:Clonazepam; D005013:Ethosuximide; D014635:Valproic Acid; D010672:Phenytoin; D010634:Phenobarbital