Response to vincristine treatment in a case of idiopathic hypereosinophilic syndrome with multiple clinical manifestations.
A case is reported of idiopathic hypereosinophilic syndrome involving many organs and systems and with a wide range of clinical findings: hematologic, cardiovascular, skin, pulmonary, spleen, liver, and gastrointestinal. Mortality in such patients is very high, but aggressive medical treatment (vincristine 2 mg/week for 5 weeks) produced a significant clinical benefit and considerably improved our patient's prognosis.
D001241:Aspirin / Q000627:therapeutic use; D004802:Eosinophilia / Q000150:complications / Q000188:drug therapy*; D006333:Heart Failure / Q000209:etiology; D006529:Hepatomegaly / Q000209:etiology; D006801:Humans; D007019:Hypoproteinemia / Q000209:etiology; D008286:Malabsorption Syndromes / Q000209:etiology; D008297:Male; D008875:Middle Aged; D013923:Thromboembolism / Q000517:prevention & control; D014262:Tricuspid Valve Insufficiency / Q000209:etiology; D014750:Vincristine / Q000627:therapeutic use*
D014750:Vincristine; D001241:Aspirin