Membrne alterations in human glioblastoma.
Plasma membrane-enriched fractions were isolated from human gliomas and brain white matter. These membrane fractions were characterized by electron microscopy and by the distribution of the membrane marker enzymes (Na+K+)-ATPase and 2',3'-cyclic AMP-3'-phosphohydrolase. The comparison of the membranes from tumor and control material by SDS gel electrophoresis reveals an altered tumor membrane. Two proteins of a molecular weight of about 70,000 dalton and 30,000 dalton are found to be more expressed in the tumor membrne.
D000251:Adenosine Triphosphatases / Q000032:analysis; D001921:Brain / Q000648:ultrastructure; D001932:Brain Neoplasms / Q000648:ultrastructure*; D002462:Cell Membrane / Q000032:analysis / Q000201:enzymology / Q000648:ultrastructure*; D005910:Glioma / Q000648:ultrastructure*; D006801:Humans; D008854:Microscopy, Electron; D008970:Molecular Weight; D011506:Proteins / Q000032:analysis
D011506:Proteins; D000251:Adenosine Triphosphatases