[Amplification of the high production and low production nature of antibodies produced by the genetic selection of mice. Correlation between immunodeficiency and the incidence of lymphoma].
Five bidirectional selective breedings have been carried out in mice for quantitative antibody responses to various natural immunogens. Appropriate crosses between the five "high responder" lines and between the five "low responder" lines resulting from these selections, were performed to obtain balanced hybrid populations. These populations were further selected for antibody production on the basis of multiple responses i.e., responses to all the antigens used in the previous separate selections. The result was a marked amplification of the interline divergence. The low line in particular has a profound deficiency for both primary and secondary responses. Moreover a high incidence of lymphomas was observed among these low responder mice (up to 42%).
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000917:Antibody Formation; D001789:Blood Group Antigens / Q000276:immunology; D002417:Cattle; D010856:Columbidae / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D005784:Gene Amplification; D007153:Immunologic Deficiency Syndromes / Q000235:genetics* / Q000276:immunology; D008223:Lymphoma / Q000235:genetics* / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics / Q000276:immunology*; D011817:Rabbits; D012486:Salmonella typhimurium / Q000276:immunology; D012710:Serum Albumin, Bovine / Q000276:immunology; D012756:Sheep / Q000276:immunology
D000907:Antibodies, Bacterial; D001789:Blood Group Antigens; D012710:Serum Albumin, Bovine
Amplification des caractères "bonne production" ou "mauvaise production" d'anticorps, produits par sélection génétique chez la souris. Corrélation entre l'immunodéficience et l'incidence de lymphomes.