title: Luteolysis in cows using the prostaglandin F2 alpha analogue, tiaprost, and the effect of mode of administration.
abstract: Thirteen cows received 0.75 mg tiaprost by subcutaneous injection during the mid-luteal phase of the ovarian cycle. Twelve underwent rapid luteolytic and continued to cycle normally as determined by milk or plasma progesterone concentrations. The other cow underwent only a transient decrease in progesterone concentrations. A further 15 cows received either a subcutaneous osmotic mini-pump containing 30 mg tiaprost , calibrated to release 0.75 mg over a 24 hour period (group 1); a subcutaneous injection of 0.375 mg tiaprost (group 2), or a subcutaneous injection of 0.375 mg tiaprost plus the osmotic mini pump (group 3). Treatment caused luteolysis in zero and one cows in groups 1 and 3 respectively. However all six cows in group 2 underwent rapid luteolysis. Although the standard therapeutic dose of tiaprost (0.75 mg) appears to be a highly effective luteolytic agent it is concluded that there may be scope for development of longer acting formulations of this compound.
mesh_terms: D000818:Animals; D002417:Cattle / Q000502:physiology*; D003338:Corpus Luteum / Q000187:drug effects*; D004343:Drug Implants; D004971:Estrus / Q000187:drug effects*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007279:Injections, Subcutaneous / Q000662:veterinary; D007986:Luteinizing Hormone / Q000097:blood; D008186:Luteolytic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D008892:Milk / Q000032:analysis; D010865:Pilot Projects; D011247:Pregnancy; D011374:Progesterone / Q000032:analysis / Q000097:blood; D011461:Prostaglandins F, Synthetic; D013876:Thiophenes / Q000008:administration & dosage* / Q000494:pharmacology
chemical_list: D004343:Drug Implants; D008186:Luteolytic Agents; D011461:Prostaglandins F, Synthetic; D013876:Thiophenes; D011374:Progesterone; C039967:tiaprost; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone