title: [Mathematical approaches to the problem of generating immunoglobulin diversity].
abstract: The frequency of mutations necessary for maintenance in the organism of the existing diversity of immunoglobulin for specificity of active centres is estimated using a mathematical model. The calculation shows the mutation frequency to be approx. 10(-2) per cell in a generation.
mesh_terms: D002999:Clone Cells / Q000276:immunology; D005802:Genes, MHC Class II; D014644:Genetic Variation; D005828:Genetics, Population; D007136:Immunoglobulins / Q000235:genetics*; D008214:Lymphocytes / Q000276:immunology; D008433:Mathematics; D008957:Models, Genetic; D009154:Mutation; D011110:Polymorphism, Genetic; D012641:Selection, Genetic
chemical_list: D007136:Immunoglobulins
vernacular_title: O matematicheskikh podkhodakh k voprosu generatsii raznoobraziia immunoglobulinov.