title: The ultrastructural characteristics of abnormal collagen fibrils in various organs.
abstract: Quite unrelated diseases affecting different organs can lead to the appearance of abnormal collagen fibrils, which may be due to genetic disorders, transformation of mesenchyme cells, increased collagen synthesis or a change in the ground-substance. The simultaneous appearance of abnormal collagen fibrils and matrix vesicles containing lysosomal enzymes in the majority of our electron photomicrographs suggests an alteration in the ground-substance as a main cause of non-hereditary collagen dysplasia.
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000473:pathology* / Q000648:ultrastructure; D002349:Carpal Tunnel Syndrome / Q000473:pathology; D003094:Collagen; D003095:Collagen Diseases / Q000473:pathology*; D004387:Dupuytren Contracture / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D051381:Rats
chemical_list: D003094:Collagen