title: Heterotopic ossification and HLA antigens.
abstract: Thirty patients with neurogenic (nontraumatic) heterotopic ossification following spinal cord injury in 20 and head injury in 10, were comprehensively screened for HLA antigens. The frequencies of 68 HLA-A, -B and -C antigens were examined. The HLA-A2 locus was present in 18 patients (60%) as compared to the phenotypically adjusted normal of 48.4% and was not statistically significant at the 0.05 level. No statistically significant increased frequency of the HLS-B18 or HLA-B27 antigens was detected. A positive correlation does not exist between the HLA antigen system and patient susceptibility to heterotopic ossification following head injury or spinal cord injury.
mesh_terms: D000328:Adult; D001930:Brain Injuries / Q000235:genetics / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000235:genetics / Q000276:immunology*; D013119:Spinal Cord Injuries / Q000235:genetics / Q000276:immunology*
chemical_list: D006680:HLA Antigens