title: Temocillin: in vitro activity against 734 selected clinical isolates, including beta-lactamase-producing strains.
abstract: The in vitro activity of temocillin against 734 clinical isolates was tested by broth microdilution. Good activity was demonstrated against Enterobacteriaceae and both beta-lactamase-positive and -negative strains of Haemophilus influenzae and Neisseria gonorrhoeae. There was little to no activity against gram-positive cocci and nonfermenting gram-negative bacilli. Bactericidal activity and effect of inoculum size on temocillin activity were comparable to that of ticarcillin. Temocillin was stable to commonly encountered beta-lactamases and significantly inhibited Richmond-Sykes type 1 enzymes of Enterobacter cloacae.
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D004355:Drug Stability; D004755:Enterobacteriaceae / Q000187:drug effects; D006193:Haemophilus influenzae / Q000187:drug effects; D006868:Hydrolysis; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects; D010406:Penicillins / Q000494:pharmacology*; D001618:beta-Lactamases / Q000032:analysis*
chemical_list: D010406:Penicillins; C031367:temocillin; D001618:beta-Lactamases