The hypoxia model in human psychopharmacology: neurophysiological and psychometric studies with aniracetam i.v.
Changes in human brain function and mental performance under hypoxic hypoxidosis as well as after intravenous injection of aniracetam - a new potentially nootropic 2-pyrrolidinone derivative - were investigated in a double-blind placebo-controlled study utilizing computer-assisted spectral analysis of the EEG and psychometric tests. Hypoxic hypoxidosis was induced by a fixed gas combination of 11.2% O2 and 88.8% N2, which was inhaled under normobaric conditions by 10 male healthy volunteers. The following substances were injected intravenously at weekly intervals according to a latin square design: placebo, 10 mg and 100 mg aniracetam and the solvent under hypoxic conditions as well as placebo under normoxic conditions. Spectral analysis of the EEG recorded under hypoxia demonstrated neurophysiological alterations indicative of a deterioration in vigilance, which was also reflected by a deterioration in psychomotor activity and mnestic performance in the psychometric tests. Aniracetam i.v. attenuated the hypoxia-induced deterioration of brain function and mental performance, thus exhibiting protective properties against hypoxia in man. The usefulness of the hypoxia model in the screening of antihypoxidotic compounds is discussed.
D000328:Adult; D001288:Attention / Q000502:physiology; D002245:Carbon Dioxide / Q000097:blood; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004569:Electroencephalography; D006801:Humans; D002534:Hypoxia, Brain / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008568:Memory / Q000502:physiology; D010100:Oxygen / Q000097:blood; D011597:Psychomotor Performance / Q000502:physiology; D011760:Pyrrolidinones / Q000627:therapeutic use*; D011930:Reaction Time / Q000502:physiology
D011760:Pyrrolidinones; D002245:Carbon Dioxide; C036466:aniracetam; D010100:Oxygen