The effect of indomethacin on the duration of the hypotensive action of bradykinin in Dahl salt-resistant rats: role of cyclooxygenase inhibition.
The Dahl salt resistant (DR) rat maintained on a low, 0.4%, or a high 8.0% salt-diet remained normotensive. The bradykinin (BK) induced falls in the systolic (SBP) and diastolic (DBP) were unaffected (P greater than 0.05) by the presence of indomethacin (5 mg/kg). Indomethacin, however, caused a substantial (P less than 0.001) reduction in the duration of the hypotensive action of bradykinin. It is speculated that the indomethacin effects result from an inhibition of the cyclooxygenase system in DR rats.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001920:Bradykinin / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors; D004351:Drug Resistance; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology; D013997:Time Factors
D016861:Cyclooxygenase Inhibitors; D012965:Sodium Chloride; D001920:Bradykinin; D007213:Indomethacin