EGF growth promoting activity is neutralized by phorbol esters.
The tumor-promoter, TPA, stimulates growth of human epithelial cells but not that of normal fibroblasts. In the presence of either EGF or FGF, TPA antagonizes the growth stimulatory activity of both factors in both cell lines.
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004815:Epidermal Growth Factor / Q000037:antagonists & inhibitors*; D005346:Fibroblast Growth Factors; D005347:Fibroblasts; D006131:Growth Inhibitors; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D008934:Mitogens / Q000494:pharmacology; D010455:Peptides / Q000037:antagonists & inhibitors*; D010704:Phorbols / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D006131:Growth Inhibitors; D007328:Insulin; D008934:Mitogens; D010455:Peptides; D010704:Phorbols; D005346:Fibroblast Growth Factors; D004815:Epidermal Growth Factor; D013755:Tetradecanoylphorbol Acetate