Decreased levels of brain cyclo-oxygenase products as a possible cause of increased seizure susceptibility in convulsion-prone gerbils.
Basal levels of 5 cerebral prostanoids (PGD2, PGF2 alpha, PGE2, 6-keto-PGF1 alpha and thromboxane/TX/B2) were measured radioimmunologically in normal and convulsion-prone gerbils. Significantly less PGD2,PGE2 and 6-keto-PGF1 alpha was found in the brain of seizure-sensitive animals. After treatment with indomethacin, which reduced the amount of brain cyclo-oxygenase products, also normal gerbils exhibited convulsions following environmental stress. The results are in accordance with the hypothesis that endogenous prostanoids play a role in the regulation of seizure susceptibility.
D000527:Alprostadil / Q000031:analogs & derivatives*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D015237:Dinoprost; D015232:Dinoprostone; D004198:Disease Susceptibility; D005260:Female; D005849:Gerbillinae / Q000378:metabolism*; D008297:Male; D015230:Prostaglandin D2; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D011457:Prostaglandins D / Q000032:analysis; D011458:Prostaglandins E / Q000032:analysis; D011460:Prostaglandins F / Q000032:analysis; D012640:Seizures / Q000378:metabolism*; D013929:Thromboxane B2 / Q000032:analysis
D011457:Prostaglandins D; D011458:Prostaglandins E; D011460:Prostaglandins F; D013929:Thromboxane B2; C022950:6-ketoprostaglandin E1; D015237:Dinoprost; D011451:Prostaglandin-Endoperoxide Synthases; D000527:Alprostadil; D015232:Dinoprostone; D015230:Prostaglandin D2