Experimental auto-allergic sialoadenitis in male rats.
Induced auto-allergic lesions in the submandibular glands of rats were studied by immunofluorescence. Direct staining with a goat anti-rat IgG conjugate was negative. Indirect immunofluorescence revealed a high incidence of anti-salivary-duct antibodies in sera from both control and experimental groups. In individual rats, no relationship was found between the presence or absence of serum anti-salivary antibodies and the presence or absence of salivary auto-allergic lesions. We conclude that the antibodies demonstrated do not play a role in the pathogenesis of the disease.
D000818:Animals; D000918:Antibody Specificity; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D007114:Immunization; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D012463:Saliva / Q000276:immunology; D012466:Salivary Gland Diseases / Q000276:immunology*; D012793:Sialadenitis / Q000276:immunology*; D013363:Submandibular Gland / Q000276:immunology
D001323:Autoantibodies