In vitro studies of moxalactam (LY127935), a new beta-lactam antibiotic with significant activity against gram-negative bacteria.
Moxalactam (LY127935) is a new beta-lactam antibiotic which is chemically related to the cephalosporins. The agent is highly active against the Enterobacteriaceae, with most organisms sensitive to 0.1 mcg/ml or less. It is also active at low concentration against gentamicin-resistant strains of Providencia and Serratia. Minimal inhibitory concentrations of moxalactam for Pseudomonas aeruginosa are approximately four-fold lower than those of carbenicillin for the same isolates. It is highly active against Hemophilus influenzae, including ampicillin-resistant strains, with all strains tested sensitive to 0.1 mcg/ml or less. The majority of strains of Neisseria gonorrheae and Neisseria meningitidis are sensitive to 0.1 mcg/ml or less. Moxalactam is more active against Bacteroides fragilis than cefoxitin. However, activity of moxalactam against gram-positive cocci was uniformly less than cephalothin and other cephalosporins tested. Little effect of inoculum size was observed with moxalactam except for particular strains of gram-negative bacilli. The drug was found to be 40-43% bound to human serum proteins.
D000583:Amikacin / Q000494:pharmacology; D000667:Ampicillin / Q000494:pharmacology; D002228:Carbenicillin / Q000494:pharmacology; D002440:Cefoxitin / Q000494:pharmacology; D002444:Cefuroxime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D002513:Cephamycins / Q000494:pharmacology*; D002981:Clindamycin / Q000494:pharmacology; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects*; D006089:Gram-Negative Anaerobic Bacteria / Q000187:drug effects*; D006193:Haemophilus influenzae / Q000187:drug effects; D009070:Moxalactam; D010068:Oxacillin / Q000494:pharmacology
D002511:Cephalosporins; D002513:Cephamycins; D002981:Clindamycin; D002440:Cefoxitin; D000667:Ampicillin; D000583:Amikacin; D002228:Carbenicillin; D002444:Cefuroxime; D010068:Oxacillin; D009070:Moxalactam