Nonspecific immunosuppression by cultured lymphocyte supernates of cancer patients.
A nonspecific immunosuppressive factor, lymphocyte immunosuppive substance (LIS), has been correlated with cancer patients. Significant suppression of IgM antibody production of sheep erythrocyte immune Swiss mice lymphocytes was found when the immune lymphocytes were treated with cultured peripheral blood lymphocyte supernates of tumor-bearing patients. A lesser amount of LIS activity was also demonstrated with patients who had cancer in the past, but were clinically free of disease at the time of testing. This suppressive activity has been demonstrated with several solid tumors including breast CA, colon CA, melanoma, uterine CA, and ovarian CA. A possible use of this suppression test for detecting recurrences is suggested from the data.
D000328:Adult; D000368:Aged; D000818:Animals; D000917:Antibody Formation; D002478:Cells, Cultured; D005260:Female; D006462:Hemolytic Plaque Technique; D006801:Humans; D007108:Immune Tolerance; D007075:Immunoglobulin M / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008875:Middle Aged; D009369:Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D007075:Immunoglobulin M