title: [Specific immunological reactivity in generalized forms of meningococcal infection in children].
abstract: The characteristics of immune responsiveness were studied in 455 children aged 2 months to 14 years with the generalized forms of meningococcal infection. In children of all age groups an increase in the titers of antibodies to meningococci was revealed; this increase started from day 4 of the disease, reached its maximum at the end of week 3 or the beginning of week 4 and correlated with the severity of the disease and the age of the patients. A drop in the IgG level in the course of the disease and a rise in the IgM level by the end of week 2 were observed. A decrease in the content of T-lymphocytes at the acute period of the disease and an increase in the number of B-lymphocytes, especially by the end of week 2 of the disease, were established.
mesh_terms: D000293:Adolescent; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007111:Immunity, Cellular; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007223:Infant; D008589:Meningococcal Infections / Q000276:immunology*; D009345:Neisseria meningitidis / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
vernacular_title: Sostoianie spetsificheskoĭ immunologicheskoĭ reaktivnosti pri generalizovannykh formakh meningokokkovoĭ infektsii u deteĭ.