[Calcium dependent hepatotoxicity of the ionophore A23187 studied by the experimental model of rat liver isolated and perfused in vitro].
Ionophore A23187, an agent that promoves Ca2+ influx into cells, significantly increases enzymatic leakage of AST and LDH into the medium by perfused rat livers. This work provides evidence that Ca2+ dependent hepatotoxicity can be studied conveniently in vitro whit isolated and perfused rat livers, since this model respects integrity of organ and duplicates many its in vivo functions.
D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D000001:Calcimycin / Q000633:toxicity*; D002118:Calcium / Q000494:pharmacology*; D004357:Drug Synergism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D000001:Calcimycin; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D002118:Calcium
Epatotossicita' calcio-dipendente dello ionoforo A23187 studiata col modello sperimentale del fegato di ratto isolato e perfuso in vitro.