Microwave enhancement of membrane conductance: effects of EDTA, caffeine and tetracaine.
Effects of tetracaine and caffeine on snail neurons were studied. They displayed depolarization and an increase of membrane conductance. In addition, tetracaine diminished membrane time constant whereas caffeine augmented hyperpolarizing after-potential. It was also shown that tetracaine blocks the caffeine effect. Microwave irradiation of snail neurons enhanced membrane conductance. This effect was not observed in neurons treated with tetracaine or injected with EDTA. Analysis of these results points to intracellular free calcium as a possible trigger of snail neuron microwave response.
D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D004492:Edetic Acid / Q000494:pharmacology*; D004553:Electric Conductivity; D006372:Helix, Snails; D066298:In Vitro Techniques; D008872:Microwaves; D009474:Neurons / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D013748:Tetracaine / Q000494:pharmacology*
D013748:Tetracaine; D002110:Caffeine; D004492:Edetic Acid