Activity of the anthracycline agent, 7-con-O-methylnogarol (7-OMEN), administered orally to mice bearing P388 or L1210 leukemia.
The magnitudes of the therapeutic and toxic responses observed when 7-con-O-methylnogarol (7-OMEN) was administered orally to mice inoculated ip or iv with P388 of L1210 leukemia were essentially equivalent to those seen after ip administration of the drug, indicating a significant degree of gastrointestinal absorption.
D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003630:Daunorubicin / Q000031:analogs & derivatives*; D007274:Injections, Intraperitoneal; D007939:Leukemia L1210 / Q000188:drug therapy*; D007941:Leukemia P388 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008297:Male; D017290:Menogaril; D009621:Nogalamycin / Q000008:administration & dosage* / Q000031:analogs & derivatives
D000970:Antineoplastic Agents; D017290:Menogaril; D009621:Nogalamycin; D003630:Daunorubicin