Gastro-intestinal motor disturbances induced by lysine-acetylsalicylate treatment in sheep.
The effects of intravenous (i.v.), intramuscular (i.m.) and oral administration of lysine-acetylsalicylate (Lys-ASA) on gastro-intestinal motility were investigated in sheep using electromyography. A dose of 20 mg/kg Lys-ASA intravenously reduced the frequency of reticular contractions for 86 +/- 18 min, produced abomasal hypomotility and caused a disruption of the cyclical pattern of intestinal motility for at least 120 min. The frequency of reticular contractions measured from 20 to 30 min after Lys-ASA administration was negatively correlated (r = 0.97; P less than 0.01) to the log of the dose used for doses varying from 10 to 40 mg/kg. Similar effects were observed with intramuscular and oral dose rates of 40 and 80 mg/kg, respectively. Previous i.v. administration of phentolamine (0.1 mg/kg) or tolazoline (2 mg/kg) abolished the effects of Lys-ASA (20 mg/kg) administered intravenously on both reticular contractions and abomaso-intestinal motility. It was concluded that Lys-ASA administered at therapeutic doses in sheep produced gastro-intestinal motor disturbances and that alpha- and alpha 2-adrenergic antagonists are able to block them.
D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D004576:Electromyography; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008239:Lysine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D010646:Phentolamine / Q000008:administration & dosage / Q000494:pharmacology; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced*; D014043:Tolazoline / Q000008:administration & dosage / Q000494:pharmacology
D014043:Tolazoline; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate; D010646:Phentolamine