[Penetration and binding strength of cadmium and its complexes with dithiols in cells].
It was shown in experiments with three types of cells (dog red cells, hepatic cells of newborn Wistar rats, and culture of the renal epithelium of Vero monkeys) that cadmium in complexes with dimercaptoethanol penetrates the cells in an 8-33-fold greater amounts than free cations of metal. Unithiol increases cadmium penetration in the cells by 1.6-3 times only. The strength of cadmium binding with dimercaptopropranolol in the cells is greater than that with unithiol and free cations. Albumin limits penetration of free cations of cadmium and of complexes with dimercaptothiol to a greater degree than that of cadmium complexes with unithiols. The reasons for the differences revealed are discussed.
D000042:Absorption; D000818:Animals; D002104:Cadmium / Q000032:analysis / Q000378:metabolism*; D002460:Cell Line; D002478:Cells, Cultured; D004112:Dimercaprol / Q000378:metabolism*; D004285:Dogs; D004912:Erythrocytes / Q000378:metabolism*; D005609:Free Radicals; D000882:Haplorhini; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000378:metabolism; D013054:Spectrophotometry, Atomic; D014494:Unithiol / Q000378:metabolism
D005609:Free Radicals; D012709:Serum Albumin; D002104:Cadmium; D004112:Dimercaprol; D014494:Unithiol
Proniknovenie i prochnost' sviazyvaniia kadmiia i ego kompleksov s ditiolami v kletkakh.