Neonatal-6-hydroxydopamine treatment: model of susceptibility for self-mutilation in the Lesch-Nyhan syndrome.
Neonatal-6-OHDA treated rats given L-DOPA after a decarboxylase inhibitor showed a high incidence of self-mutilation behavior (SMB) and self-biting. These behaviors were not observed in adult-6-OHDA-treated rats or in controls. Since inhibition of dopamine-beta-hydroxylase did not prevent or inhibit the SMB exhibited in neonatal-6-OHDA-treated rats after L-DOPA, norepinephrine is not likely to be contributing to this response. The age dependent effects observed are consistent with the hypothesis that neonatal reduction of dopamine-containing fibers is responsible for the SMB susceptibility observed in Lesch-Nyhan disease, making the neonatal-6-OHDA-treated rat a model of this neurological syndrome.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D004195:Disease Models, Animal; D006801:Humans; D006892:Hydroxydopamines; D007926:Lesch-Nyhan Syndrome / Q000209:etiology*; D007980:Levodopa / Q000633:toxicity; D008297:Male; D016627:Oxidopamine; D051381:Rats; D011954:Receptors, Dopamine / Q000502:physiology*; D012652:Self Mutilation / Q000209:etiology*
D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D007980:Levodopa; D016627:Oxidopamine