Elephantiasis neuromatosa. A light, immunohistochemical and electron microscopic study.
An example of elephantiasis neuromatosa, an unusual variant of neurofibromatosis, coexistent with lipomatosis is presented. This dual cell population produced a diffuse swelling of the gluteal sulcus of a young female. The neurogenous origin of the spindle cell component was substantiated by immunoreactivity for S-100 protein as well as by the fine structural observation of a regular basement membrane coating and a profusion of Luse bodies. As far as can be ascertained, this is the first reported immunohistochemical and ultrastructural study of this particular variant of peripheral nerve sheath lesion.
D000293:Adolescent; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007120:Immunochemistry; D008068:Lipomatosis / Q000150:complications; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000473:pathology; D009456:Neurofibromatosis 1 / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D010524:Peripheral Nervous System Neoplasms / Q000150:complications / Q000378:metabolism / Q000473:pathology*; D009418:S100 Proteins / Q000378:metabolism
D009418:S100 Proteins