Midazolam-induced increase in NaCl solution ingestion: differential effect of the benzodiazepine antagonists Ro 15-1788 and CGS 8216.
After adaptation to a 23-hr water deprivation regimen, under which rats were allowed a daily 1-hr water rehydration session, they were injected (SC) with 1 or 2 drugs presession and given 1.5% NaCl solution to drink in place of water. Midazolam (0.5-1.0 mg/kg) increased the intake of 1.5% NaCl solution as did Ro 15-1788 (2.5-10.0 mg/kg). This confirmed a previously noted agonist effect of midazolam and partial agonist action of Ro 15-1788. When injected in combination with midazolam, Ro 15-1788 (2.5-10.0 mg/kg) antagonized the effect of midazolam. CGS 8216 (2.5-20.0 mg/kg) revealed no partial agonist action on the NaCl solution ingestion procedure nor did it block the effect of midazolam.
D000818:Animals; D001066:Appetite / Q000187:drug effects*; D001569:Benzodiazepines / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000494:pharmacology*; D004347:Drug Interactions; D005442:Flumazenil; D008297:Male; D008874:Midazolam; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D012965:Sodium Chloride
D001570:Benzodiazepinones; D011720:Pyrazoles; D001569:Benzodiazepines; D005442:Flumazenil; D012965:Sodium Chloride; C033830:2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one; D008874:Midazolam