Synthesis of no-carrier-added L- and D-[1-11C]-DOPA.
No-carrier-added DL-[1-11C]-DOPA has been synthesized by carboxylation of an alpha-lithioisocyanide with a radiochemical yield of up to 15% without correction for decay. The total synthesis time is 30 min. The resolution of the D- and L-isomers was accomplished within 16 min by HPLC using a chiral stationary phase and a phosphate buffer of pH 4.5 as eluent.
D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism; D004295:Dihydroxyphenylalanine / Q000138:chemical synthesis*; D006801:Humans; D007553:Isotope Labeling / Q000379:methods; D007980:Levodopa / Q000138:chemical synthesis*; D009369:Neoplasms / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging
D007980:Levodopa; D004295:Dihydroxyphenylalanine