[Effect of adenosine triphosphate (ATP) on the secretion of insulin induced by tolbutamide in the absence of glucose].
Our experiments were carried out on the isolated perfused rat pancreas. The effect of ATP on insulin secretion induced by tolbutamide (a hypoglycemic sulfonylurea) was studied in the absence of glucose. The addition of ATP (0.165 mmol/l) to the perfusion medium did not significantly modify the first phase induced by tolbutamide (0.4 mmol/l) but potentiated the second phase.
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D005947:Glucose / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D051381:Rats; D014044:Tolbutamide / Q000494:pharmacology*
D007328:Insulin; D000255:Adenosine Triphosphate; D014044:Tolbutamide; D005947:Glucose
Effet de l'adénosine triphosphate (ATP) sur la sécrétion d'insuline induite par le tolbutamide en l'absence de glucose.