Distribution of lysozyme (muramidase) and alpha 1-antichymotrypsin in normal and neoplastic epithelial tissues: a survey.
Lysozyme and alpha 1-antichymotrypsin are useful in differentiation of histiocytic tumours. Both enzymes, however, also can be expressed in epithelial tissues. In contrast to lysozyme, alpha 1-antichymotrypsin is more often found to be positive in non-histiocytic neoplasias. In general, the activity of parent tissue is retained in tumour cells. In malignant melanoma and in single cases of other epithelial tumours an activity of alpha 1-antichymotrypsin was found which could not be demonstrated in normal parent tissue and which may find its explanation in a dedifferentiation of tumour cells.
D002918:Chymotrypsin / Q000037:antagonists & inhibitors* / Q000378:metabolism; D004848:Epithelium / Q000201:enzymology / Q000473:pathology; D006644:Histiocytes / Q000201:enzymology; D006801:Humans; D009113:Muramidase / Q000378:metabolism*; D009369:Neoplasms / Q000201:enzymology* / Q000473:pathology; D000514:alpha 1-Antichymotrypsin
D000514:alpha 1-Antichymotrypsin; D009113:Muramidase; D002918:Chymotrypsin