Phenytoin-induced increase in growth hormone response to levodopa in adult males.
Growth hormone and prolactin response to levodopa were evaluated before and after long-term phenytoin treatment in five men with previously untreated partial epilepsy. After phenytoin treatment, growth hormone response to levodopa increased. There was a close relationship between growth hormone response to levodopa and plasma phenytoin concentrations. These findings suggest a phenytoin-induced dopaminergic activity at the hypothalamic-pituitary level in adult males.
D000328:Adult; D004828:Epilepsies, Partial / Q000097:blood / Q000188:drug therapy*; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D007980:Levodopa; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000627:therapeutic use*; D011388:Prolactin / Q000097:blood; D011954:Receptors, Dopamine / Q000187:drug effects
D011954:Receptors, Dopamine; D007980:Levodopa; D010672:Phenytoin; D011388:Prolactin; D013006:Growth Hormone