[Effectiveness of treatment of patients with acute myocardial infarction by intracoronary administration of nitroglycerin and streptokinase].
The intracoronary administration of nitroglycerin and streptokinase was assigned to 95 patients with acute myocardial infarction. In 69 (79.3%) out of the 87 occluded coronary arteries the antegrade blood flow was restored. After the thrombolysis, aortocoronary shunting was performed in 26 patients and transcutaneous transluminal coronary angioplastic surgery in five patients. In 71 patients control angiographic examination was carried out 17-185 days later. It was revealed that in 73.7% of drug-treated patients, the antegrade blood flow was retained for an average of 37 days. Patients with the intact coronary blood flow after the thrombolysis exhibited a positive pattern of the parameters of left ventricular contractile function which was especially expressed following aortocoronary bypassing. In cases of thrombolysis failure or reocclusion, left ventricular contractility had a negative profile.
D000328:Adult; D000368:Aged; D003331:Coronary Vessels / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D009203:Myocardial Infarction / Q000188:drug therapy*; D005996:Nitroglycerin / Q000008:administration & dosage*; D012039:Regional Blood Flow / Q000187:drug effects; D013300:Streptokinase / Q000008:administration & dosage*
D013300:Streptokinase; D005996:Nitroglycerin
Effektivnost' lecheniia bol'nykh ostrym infarktom miokarda vnutrikoronarnym vvedeniem nitroglitserina i streptokinazy.