The mechanism of the anti-inflammatory effect of turpentine in the rat.
The influence of counter irritation by turpentine on carrageenan-oedema, leucocyte count, plasma kininogen stores and composition of sponge-induced exudates has been investigated in the rat. Counter irritation reduced the carrageenan-oedema in normal as well as in adrenalectomized rats. It induced leucopenia with lymphopenia but did not modify the plasma kininogen stores. In turpentine-pretreated rats, the exudates induced by sponge implantation 18 h previously had a lower content in leucocytes. Their levels in beta-glucuronidase and beta-galactosidase were slightly reduced, their content in PGE2 was not modified and their level in malonaldehyde was increased. The exudates induced by sponge implantation 4 h previously had a lower content in leucocytes and PGE2 while their level in kinins was not modified. The mechanism of the anti-inflammatory effect of counter irritation by turpentine is discussed. We suggest that the main factor involved is a decrease in leucocyte accumulation into the exudates.
D000315:Adrenalectomy; D000818:Animals; D000893:Anti-Inflammatory Agents; D015232:Dinoprostone; D004487:Edema / Q000188:drug therapy; D005122:Exudates and Transudates / Q000187:drug effects; D005260:Female; D005966:Glucuronidase / Q000378:metabolism; D007704:Kininogens / Q000097:blood; D007705:Kinins / Q000378:metabolism; D007958:Leukocyte Count; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D011458:Prostaglandins E / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014425:Turpentine / Q000494:pharmacology*; D001616:beta-Galactosidase / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D007704:Kininogens; D007705:Kinins; D011458:Prostaglandins E; D008315:Malondialdehyde; D001616:beta-Galactosidase; D005966:Glucuronidase; D015232:Dinoprostone; D014425:Turpentine