[Redistribution of Ca2+ ions in lymphocyte suspensions after treatment with an ionophore].
Ionophore A23187 induces three-phase kinetics of reduction of chlorotetracycline (CTC) lauded lymphocyte fluorescence: fast reduction, low increase and lower reduction of fluorescence. We suggested the following explanation of kinetics. The first phase is extinguishing of the Ca2+ - CTC complex fluorescence induced by ionophore A23187 perturbation of the cell membrane, the second one is the energy dependent Ca2+ entry into the cell and the third one is the slow efflux of Ca2+ ions from the cell to concentration gradient.
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000187:drug effects; D005453:Fluorescence; D066298:In Vitro Techniques; D007700:Kinetics; D008214:Lymphocytes / Q000378:metabolism*; D051379:Mice
D000001:Calcimycin; D002118:Calcium
Pereraspredelenie ionov Ca2+ v suspenzii limfotsitov pod deĭstviem ionofora.