Methionine sulfoxide formation: the cause of self-inactivation of reticulocyte lipoxygenase.
Under conditions leading to inactivation of reticulocyte lipoxygenase by 13LS-hydroperoxylinoleic acid a single methionine, presumably in the active center of the enzyme, is oxidized to methionine sulfoxide.
D000818:Animals; D001665:Binding Sites; D066298:In Vitro Techniques; D008084:Lipoxygenase / Q000097:blood*; D016859:Lipoxygenase Inhibitors; D008715:Methionine / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000494:pharmacology; D010446:Peptide Fragments; D011817:Rabbits; D012156:Reticulocytes / Q000201:enzymology*
D016859:Lipoxygenase Inhibitors; D010446:Peptide Fragments; D008715:Methionine; D008084:Lipoxygenase; C013111:methionine sulfoxide