Stimulation of acid and pepsin secretions in fistulated cats by dimaprit-like compounds.
In the present paper the Authors describe the effects of dimaprit analogs on cat gastric acid and pepsin secretions. Such compounds are only weakly active as stimulants of H2-receptors, and studied as antagonists fail to inhibit acid and pepsin secretions evoked by dimaprit. The different mechanisms of action of dimaprit and histamine on H2-receptors are discussed.
D000818:Animals; D002415:Cats; D017259:Dimaprit; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D010434:Pepsin A / Q000378:metabolism*; D011968:Receptors, Histamine / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*; D013268:Stimulation, Chemical; D013270:Stomach / Q000502:physiology; D013890:Thiourea / Q000494:pharmacology*
D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D010434:Pepsin A; D013890:Thiourea; D017259:Dimaprit