title: Thyroid function and affective illness: a reappraisal.
abstract: It has been generally accepted that increased thyroid function facilitates treatment response in depression. Recent data show that response to several antidepressant treatments, particularly lithium and carbamazepine, are associated with decreased thyroid hormone levels. An alternative hypothesis that decreased thyroid indices are related to antidepressant response is proposed and clinical and research implications are discussed.
mesh_terms: D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000097:blood* / Q000188:drug therapy; D002220:Carbamazepine / Q000627:therapeutic use; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy; D004565:Electroconvulsive Therapy; D006801:Humans; D007037:Hypothyroidism / Q000097:blood; D008094:Lithium / Q000627:therapeutic use; D016651:Lithium Carbonate; D013963:Thyroid Hormones / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone
chemical_list: D000929:Antidepressive Agents, Tricyclic; D013963:Thyroid Hormones; D016651:Lithium Carbonate; D002220:Carbamazepine; D013973:Thyrotropin-Releasing Hormone; D008094:Lithium