[Effect of different combinations of exogenous higher fatty acids on cardiac function during coronary ischemia and reperfusion].
Experiments on 77 white random-bred male rats weighing 200 +/- 10 g have shown that combinations of high unsaturated fatty acids (HUFA) containing the precursors of prostaglandin synthesis, arachidonic and linoleic acids, produce a powerful antiarrhythmic action during transitory coronary insufficiency. The effect was seen not only during ischemia but also during subsequent myocardial reperfusion. The combination of HUFA containing arachidonic and linoleic acids as precursors of prostaglandin synthesis exerted a more demonstrable antiarrhythmic action than that without arachidonic acid. The degree of the ischemia-induced depression of contractile process was less versus control, provided HUFA combinations contained arachidonic acid.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000008:administration & dosage; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control*; D003327:Coronary Disease / Q000150:complications*; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats
D001095:Arachidonic Acids; D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D011453:Prostaglandins; D016718:Arachidonic Acid; D019787:Linoleic Acid
Vliianie razlichnykh kombinatsiĭ ékzogennykh vysshikh zhirnykh kislot na funktsiiu serdtsa pri ego koronarogennoĭ ishemii i reperfuzii.