Pargyline and deprenyl prevent the neurotoxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in monkeys.
D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006719:Homovanillic Acid / Q000378:metabolism; D008252:Macaca fascicularis; D010293:Pargyline / Q000494:pharmacology / Q000627:therapeutic use*; D010302:Parkinson Disease, Secondary / Q000139:chemically induced / Q000517:prevention & control; D010627:Phenethylamines / Q000627:therapeutic use*; D011725:Pyridines / Q000037:antagonists & inhibitors / Q000633:toxicity*; D012642:Selegiline / Q000494:pharmacology / Q000627:therapeutic use*
D010627:Phenethylamines; D011725:Pyridines; D012642:Selegiline; D010293:Pargyline; D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D004298:Dopamine; D006719:Homovanillic Acid