[Separation of high density lipoproteins (HDL) using zonal ultracentrifugation in patients with apolipoprotein AI Milano variant].
Investigations of HDL with zonal ultracentrifugation were carried out in three patients with apolipoprotein AIMilano. HDL in patients with AIMilano apolipoprotein are characterized by the practically total absence of HDL2. The HDL3 peak is broader than normal. In spite of the marked reduction or practically total absence of HDL2, which is believed to be a protective factor against atherosclerosis, our patients show no signs of clinical atherosclerosis.
D000328:Adult; D016632:Apolipoprotein A-I; D001053:Apolipoproteins / Q000097:blood* / Q000235:genetics; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL; D005260:Female; D006801:Humans; D008052:Lipid Metabolism, Inborn Errors / Q000097:blood* / Q000235:genetics; D008075:Lipoproteins, HDL / Q000097:blood / Q000302:isolation & purification*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood; D014461:Ultracentrifugation / Q000379:methods
D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D014280:Triglycerides; D002784:Cholesterol
Trennung der Lipoproteine hoher Dichte (HDL) mittels zonaler Ultrazentrifugierung bei Patienten mit der Apolipoprotein-AIMilano-Variante.