Replication of Borna disease virus in rats: age-dependent differences in tissue distribution.
There are age-dependent differences in the tissue distribution of Borna disease (BD) virus in rats infected intracerebrally. While in adult rats BD virus replication is restricted to neural cells, in neonatally infected rats infectious virus or viral antigens were found in the cells of most organs. The possibility that differences in the immune status between newborn and adult animals are responsible for different tissue susceptibility could be excluded.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D000956:Antigens, Viral / Q000302:isolation & purification; D001890:Borna Disease / Q000276:immunology / Q000382:microbiology*; D001891:Borna disease virus / Q000254:growth & development* / Q000276:immunology; D001921:Brain / Q000382:microbiology; D009928:Organ Specificity; D051381:Rats; D011917:Rats, Inbred Lew; D012160:Retina / Q000382:microbiology; D014779:Virus Replication; D014713:Viruses, Unclassified / Q000254:growth & development*
D000956:Antigens, Viral