Influence of EHDP and F on Ca and P loss from enamel during the intra-oral cariogenicity test.
The effect of anticalculus agent EHDP (0.05%) on caries has been studied in the presence and absence of 0.1% F- under the conditions Intra Oral Cariogenicity Test (ICT). Whereas EHDP had no influence on the change in microhardness of the produced by sucrose in the presence of absence of fluoride, it increased the F- effect inside the lesion thereby preventing the formation of minerals with a mol Ca/P ratio deviating from apatite. The EHDP effect was additioned to the F- effect demonstrating that both components act independently of one other. In this respect it has been suggested that 0.05% EHDP acts mainly on demineralization by decreasing the acid production of the micro-organisms whereas F- stimulates remineralization particularly by acting on the enamel surface.
D000818:Animals; D002118:Calcium / Q000032:analysis*; D002417:Cattle; D003732:Dental Caries Activity Tests / Q000379:methods; D003743:Dental Enamel / Q000032:analysis / Q000187:drug effects*; D003745:Dental Enamel Permeability / Q000187:drug effects; D003829:Denture, Partial; D012968:Etidronic Acid / Q000494:pharmacology*; D005461:Fluorine / Q000494:pharmacology*; D006245:Hardness Tests; D006801:Humans; D010758:Phosphorus / Q000032:analysis*; D013395:Sucrose / Q000494:pharmacology; D013997:Time Factors
D010758:Phosphorus; D005461:Fluorine; D013395:Sucrose; D012968:Etidronic Acid; D002118:Calcium