Platelet function during haemoperfusion in acute liver failure.
The changes in platelet-related haemostatic parameters have been studied during haemoperfusion of eleven patients with acute liver failure. Five patients were treated by haemoperfusion with an albumin-coated resin column and six with a polymer-coated charcoal column. The platelet and white cell losses over four hours' haemoperfusion were small in both groups. Significant increases in beta-thromboglobulin (mean 341 +/- SE 145 ng/ml) were seen after one hour in the patients treated by charcoal haemoperfusion. One patient in the charcoal group with the greatest rises in beta-thromboglobulin (860 ng/ml) and screen filtration pressure (205 mmHg) developed severe hypotension and haemoperfusion was terminated after 1 hour. One patient in the resin group showed rapid consumption of heparin after 2 hours. Measurement of beta-thromboglobulin is a sensitive assay of platelet activation during haemoperfusion. Albumin-coated resin haemoperfusion appears to be a more blood-compatible procedure with respect to platelets than charcoal haemoperfusion.
D000180:Acrylic Resins; D001792:Blood Platelets / Q000502:physiology*; D002606:Charcoal; D005374:Filtration; D006464:Hemoperfusion / Q000295:instrumentation; D006493:Heparin / Q000097:blood; D006501:Hepatic Encephalopathy / Q000097:blood / Q000628:therapy*; D006801:Humans; D010974:Platelet Aggregation; D010976:Platelet Count; D010978:Platelet Factor 4 / Q000032:analysis; D011137:Polystyrenes; D011312:Pressure; D001620:beta-Thromboglobulin / Q000032:analysis
D000180:Acrylic Resins; D011137:Polystyrenes; D001620:beta-Thromboglobulin; D002606:Charcoal; D010978:Platelet Factor 4; D006493:Heparin