Genetic control of the murine IgM plaque-forming cell response to type III pneumococcal polysaccharide.
The direct 5-day plaque-forming cell response of different inbred mouse strains to pneumococcal polysaccharide type III (SSS-III) varied from more than 10,000 per spleen, in BALB/c mice, to less than 2000 in C57BL mice. Responses of Igh congenic and recombinant inbred lines bearing different combinations of BALB/c and C57BL genes indicate that two or more gene loci are involved in controlling high or low responses. At least one is in the Igh-V region since BALB/c, BAB-14, and CB-8 KN mice (Igh-Va) had two to four times higher responses than CB-20 and CB-16 KN mice (Igh-Vb). Other gene loci must be involved, but nothing can be said about them at present.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006462:Hemolytic Plaque Technique; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007075:Immunoglobulin M / Q000096:biosynthesis* / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000235:genetics; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008814:Mice, Inbred NZB; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage / Q000276:immunology*; D013045:Species Specificity
D007143:Immunoglobulin Heavy Chains; D007075:Immunoglobulin M; D007135:Immunoglobulin Variable Region; D011135:Polysaccharides, Bacterial; C027158:polysaccharide C-substance (Streptococcus)