High-frequency positive-pressure ventilation with the MA-1 ventilator.
A conventional, low-frequency ventilator was modified to ventilate dogs at high frequencies of 85 to 185 cycle/min while cardiovascular and pulmonary variables were monitored. Although gas transport was adequate, cardiac output was diminished when compared to low-frequency ventilation. The addition of an in-line pneumotachograph markedly increased PaCO2 during high-frequency ventilation. Carbon dioxide transport was primarily dependent upon the magnitude of the tidal volume at all high frequencies tested.
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D002302:Cardiac Output; D004285:Dogs; D006439:Hemodynamics; D008991:Monitoring, Physiologic; D011175:Positive-Pressure Respiration / Q000379:methods*; D011659:Pulmonary Gas Exchange; D012126:Respiratory Dead Space; D013990:Tidal Volume; D012122:Ventilators, Mechanical
D002245:Carbon Dioxide