Mutagenic potential of 4 organophosphinate compounds.
The mutation frequency of four organophosphinate compounds at various concentrations currently being investigated for their prophylactic ability in anticholinesterase poisoning was assessed using the sexlinked recessive lethal (SLRL) assay. Fisher's Exact Test indicated non-significant differences (P greater than 0.05) for: 4-nitrophenyl methyl (phenyl) phosphinate at 0.002 mM; 4-nitrophenyl monochloromethyl (phenyl) phosphinate at 0.007, 0.05 and 0.01 mM; 4-nitrophenyl diphenyl phosphinate at 0.35 and 0.51 mM; and 4-nitrophenyl dimethyl phosphinate at 0.005 and 0.01 mM compared to concurrent negative controls. This non-mutagenic activity of these four compounds was also confirmed by other researchers using the Ames assay.
D000818:Animals; D004331:Drosophila melanogaster / Q000187:drug effects*; D005260:Female; D008297:Male; D009152:Mutagenicity Tests; D009943:Organophosphorus Compounds / Q000633:toxicity*; D010721:Phosphinic Acids / Q000633:toxicity*
D009943:Organophosphorus Compounds; D010721:Phosphinic Acids