Mezlocillin pharmacokinetics in renal impairment.
Mezlocillin kinetics was examined in 28 adult subjects with varying renal function. Mezlocillin 3 gm, was infused over 30 min. Mean peak plasma concentrations ranged from 204 to 253 mg/I. When the area under the curve (AUC) was plotted against creatinine clearance (CCr), the relationship found was expressed by the equation AUC = 656e(-0.01)(CCr). From this relationship a dosage nonogram was derived describing a power function with the following equaton: Dose fraction = 1.32--e(-0.01)(CCr). Therapeutic guidelines are suggested.
D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D007700:Kinetics; D008802:Mezlocillin; D008875:Middle Aged; D010406:Penicillins / Q000378:metabolism*; D012044:Regression Analysis
D010406:Penicillins; D008802:Mezlocillin