Chelating effect of EDTA on nickel.
The chelating effect of disodium ethylenediamine tetra-acetate (EDTA) in nickel-allergic patients was investigated. After pretreatment of the right half of the patient's back with 10% EDTA in a cream, and the left half of the back with the cream base only, various concentrations of nickel sulphate were patch tested on these areas. The blocking effect of the 10% EDTA cream appeared to be significant in comparison with that of the cream base only (p less than 0.01). A barrier cream with 10% EDTA might be of help in nickel-allergic patients with eczema of the hands.
D000293:Adolescent; D000328:Adult; D003877:Dermatitis, Contact / Q000209:etiology / Q000517:prevention & control*; D004492:Edetic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006229:Hand Dermatoses / Q000517:prevention & control; D006801:Humans; D008875:Middle Aged; D009532:Nickel / Q000009:adverse effects*; D009824:Ointments; D010328:Patch Tests
D009824:Ointments; C029938:nickel sulfate; D009532:Nickel; D004492:Edetic Acid