The production of immunoregulatory factors by a human macrophage-like cell line. III. The relationship between the lymphoid-specific inhibitor of DNA synthesis and gamma-interferon.
Mitogenic stimulation of sublines of the human histiocytic lymphoma, U937, results in the production of an inhibitor of lymphocyte proliferation (IDS-U937). The relationship of IDS-U937 to alpha- and gamma-interferon was examined by several techniques: (1) the antiviral activity of the IDS preparations was determined, (2) the effects of antibodies to interferon on IDS activities, and (3) the comparison of the antiproliferative activities of gamma-IFN and IDS. The relationship of IDS to other macrophage derived inhibitors is also discussed with respect to target cell specificities and modes of action.
D002460:Cell Line; D004261:DNA Replication; D006023:Glycoproteins / Q000276:immunology* / Q000302:isolation & purification; D006801:Humans; D007371:Interferon-gamma / Q000502:physiology*; D008213:Lymphocyte Activation; D016403:Lymphoma, Large B-Cell, Diffuse; D008264:Macrophages / Q000276:immunology*
D006023:Glycoproteins; C018322:IDS protein, human; D007371:Interferon-gamma