Griseochelin, a novel carboxylic acid antibiotic from Streptomyces griseus.
Griseochelin, C33H60O7, isolated from an asporogenous strain of Streptomyces griseus represents a novel carboxylic acid antibiotic. The metabolite, which is active against Gram-positive bacteria, forms water-insoluble salts with mono- and divalent cations and binds alkaline-earth metal ions specifically in 2:1 (X2M) stoichiometry. Detailed spectral (IR, MS and NMR) studies provide full characterization of its constitution featuring a carboxylic acid function, a substituted tetrahydropyran ring, an allylic OH group which are accommodated within a tetrahydroxylated-octamethyl-C25 diene backbone.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D002264:Carboxylic Acids / Q000302:isolation & purification / Q000494:pharmacology; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D011422:Propionates; D051381:Rats; D013055:Spectrophotometry, Infrared; D013305:Streptomyces griseus / Q000032:analysis*
D000900:Anti-Bacterial Agents; D002264:Carboxylic Acids; D011422:Propionates; C043279:zincophorin