title: Intragastric bacterial activity and nitrosation before, during, and after treatment with omeprazole.
abstract: Ten healthy volunteers were studied before, during, and after treatment with omeprazole 30 mg daily for two weeks. On the 14th night mean nocturnal (2100-0700) intragastric acidity was significantly decreased by 75% (p less than 0.001). At 0700, 22 hours after the last dose of omeprazole, there were significant increases in the bacterial count and the nitrite and N-nitrosamine concentrations in the gastric juice (p less than 0.001). Three days later these changes had resolved. Short term treatment of healthy volunteers with omeprazole is associated with a short lived increase in the gastric bacterial flora, with endogenous production of N-nitroso compounds.
mesh_terms: D000328:Adult; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001419:Bacteria / Q000302:isolation & purification*; D001562:Benzimidazoles / Q000494:pharmacology*; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology; D006801:Humans; D008297:Male; D009566:Nitrates / Q000378:metabolism; D009573:Nitrites / Q000378:metabolism; D009602:Nitrosamines / Q000378:metabolism; D009603:Nitroso Compounds / Q000378:metabolism*; D009853:Omeprazole; D013997:Time Factors
chemical_list: D000897:Anti-Ulcer Agents; D001562:Benzimidazoles; D009566:Nitrates; D009573:Nitrites; D009602:Nitrosamines; D009603:Nitroso Compounds; D009853:Omeprazole