Intravascular contrast agents suitable for magnetic resonance imaging.
Two paramagnetic chelates, chromium EDTA and gadolinium DTPA, were evaluated as potential intravenous contrast agents for magnetic resonance imaging (MR) using a 0.5-T superconducting scanner. After evaluating both agents in vitro, in vivo studies were conducted in dogs to document changes in renal appearance produced by contrast injection. Acute splenic and renal infarction were diagnosed with contrast-enhanced MR and confirmed by gamma camera imaging following administration of Tc-99m-labeled DMSA and sulfur colloid. The authors conclude that intravenous paramagnetic contrast agents presently offer the best mechanism for assessment of tissue function and changes in perfusion with MR.
D000818:Animals; D003287:Contrast Media; D004285:Dogs; D004492:Edetic Acid; D005682:Gadolinium; D007238:Infarction / Q000175:diagnosis* / Q000000981:diagnostic imaging; D007668:Kidney / Q000098:blood supply*; D009682:Magnetic Resonance Spectroscopy; D004369:Pentetic Acid; D011877:Radionuclide Imaging; D013154:Spleen / Q000098:blood supply*
D003287:Contrast Media; D004369:Pentetic Acid; D004492:Edetic Acid; D005682:Gadolinium