The physical effects of visco elastic substances on human donor cornea.
A case of corneal graft operation using chondroitin sulphate (CDS-TM) to protect the endothelium, highlights the surgical difficulties encountered as a result of the severe dehydration effects on the donor corneal button produced by the CDS. In vitro experiments comparing Healonid and CDS on 8 mm excised donor corneal buttons from three pairs of human eyes, confirms this effect with CDS which was absent with Healonid.
D000328:Adult; D000368:Aged; D002807:Chondroitin / Q000031:analogs & derivatives*; D002809:Chondroitin Sulfates / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D003315:Cornea / Q000187:drug effects; D003316:Corneal Diseases / Q000139:chemically induced; D016039:Corneal Transplantation; D003681:Dehydration / Q000139:chemically induced; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male
D006820:Hyaluronic Acid; D002807:Chondroitin; D002809:Chondroitin Sulfates