Human alloimmune sera against T cell subsets. Detection and influence on pokeweed mitogen-stimulated Ig production in vitro.
Sera from multiparous women contain antibodies against T cell subsets. Population and family studies of four anti-T cell-subset antibodies are given. Two of these reacted with part of the suppressor T cell fraction (T gamma) and two with part of the helper T cell fraction (T mu) cells. By mixing T gamma- and mu-enriched cell suspensions in different concentrations, preliminary evidence was obtained that the anti-T cell-subset sera recognized T cells that had different functions in pokeweed mitogen-stimulated cytoplasmic immunoglobulin synthesis.
D000328:Adult; D000917:Antibody Formation; D000961:Antilymphocyte Serum / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000235:genetics; D006720:Homozygote; D006801:Humans; D007518:Isoantibodies; D008297:Male; D011043:Pokeweed Mitogens / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000961:Antilymphocyte Serum; D000949:Histocompatibility Antigens Class II; D007518:Isoantibodies; D011043:Pokeweed Mitogens