title: [Resistive loading and mechanisms regulating respiration].
abstract: In experiments on anesthetized cats, switch on of additional inelastic respiration resistance (resistive load) produced, apart from slowing of the respiratory flows, an increase in the activity of motoneurons and inspiratory intrathoracic pressure. Bilateral vagotomy resulted in disappearance of resistive load-induced elevation of the phrenic nerve activity, but did not abolish the growth of the inspiratory effort. Analysis of the evidence obtained indicates that activation of phrenic motoneurons associated with increased respiration resistance is underlain by prolongation of the inspiratory phase that is consequent on relaxation of the inspiratory inhibition. It is suggested that, in addition to the mechanism depicted, the compensatory reaction to the resistive load involves, apart from diaphragm participation, other inspiratory muscles as well as enhanced contractions of respiratory muscles provided by the properties of muscular fiber.
mesh_terms: D000009:Abdominal Muscles / Q000502:physiology; D000403:Airway Resistance; D000818:Animals; D002245:Carbon Dioxide / Q000032:analysis; D002415:Cats; D003964:Diaphragm / Q000502:physiology; D007366:Intercostal Muscles / Q000502:physiology; D009046:Motor Neurons / Q000502:physiology; D010313:Partial Pressure; D010791:Phrenic Nerve / Q000502:physiology*; D011650:Pulmonary Alveoli / Q000032:analysis; D012123:Pulmonary Ventilation; D012119:Respiration; D014628:Vagotomy
chemical_list: D002245:Carbon Dioxide
vernacular_title: O mekhanizmakh reguliatsii dykhaniia v usloviiakh rezistivnoĭ nagruzki.