Inhibitory activity of indobufen (*) on platelet aggregation in vivo.
Indobufen, administered by gavage, reduced mortality induced in mice and rabbits by intravenous injection of arachidonic acid (A.A.). The doses of compound required to protect 50% of the mice and rabbits from death (ED50) were 1.3 and 0.58 mg/kg respectively. Acetylsalicylic acid (ASA) was considerably less active than indobufen (ED50 = 22.4 and 8 mg/kg). Since the lethal effect of A.A. is mostly due to the formation of platelet aggregates (Silver et al., 1974; Kohler et al., 1976), it is concluded that indobufen is a very potent inhibitor of platelet aggregation in vivo.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors / Q000633:toxicity; D001241:Aspirin / Q000494:pharmacology; D003864:Depression, Chemical; D054833:Isoindoles; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010654:Phenylbutyrates / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*
D001095:Arachidonic Acids; D054833:Isoindoles; D010654:Phenylbutyrates; D016718:Arachidonic Acid; C020371:indobufen; D001241:Aspirin