Pseudomonas aeruginosa beta-lactamases.
Forty recently isolated hospital strains of Pseudomonas aeruginosa were assayed to determine the part played by the production of beta-lactamase in their resistance to beta-lactamic antibiotics, together with the relative importance of constitutive and inducible enzymes in such resistance in the case of carbenicillin (CB). 62.5% were CB-resistant. In 56% of cases, this resistance was due to the production of a class Vd constitutive enzyme, whereas it was ascribable to intrinsic resistance in the other 44%.
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D002228:Carbenicillin / Q000494:pharmacology*; D010403:Penicillin Resistance; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology*; D001618:beta-Lactamases / Q000302:isolation & purification / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D001618:beta-Lactamases; D002228:Carbenicillin