Efficacy of ivermectin against the mange mite Sarcoptes scabiei var suis in pigs.
The efficacy of ivermectin administered by esophageal intubation in a single dose was evaluated against the mange mite Sarcoptes scabiei var suis in 24 naturally infested pigs. Six pigs were allocated to each of the 4 treatment groups. Control (group 1) pigs were given nonmedicated water, group 2 were given ivermectin at 300 micrograms/kg of body weight, group 3 were given ivermectin at 400 micrograms/kg, and group 4 were given ivermectin at 500 micrograms/kg. The pigs were examined for S scabiei before treatment and on days 7, 14, 21, and 28 after treatment. Of the 18 ivermectin-treated pigs, 10 had no live S scabiei recovered on day 7 after treatment, 16 had none on day 14, 18 had none on day 21, and 16 had none on day 28. All 6 nonmedicated control pigs had live S scabiei recovered on days 7 and 21, and 5 control pigs had mites on days 14 and 28. The single administration of ivermectin given by esophageal intubation was highly effective in reducing the number of S scabiei at all dose levels tested. The pooled ivermectin-treated groups had significantly (P less than 0.01) fewer mites than the control group on all posttreatment examination days. There were no statistically significant differences among the ivermectin dose levels.
D000818:Animals; D004431:Ear, External; D004947:Esophagus; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use*; D007440:Intubation / Q000662:veterinary; D007559:Ivermectin; D007783:Lactones / Q000008:administration & dosage / Q000627:therapeutic use*; D012520:Sarcoptes scabiei; D012532:Scabies / Q000188:drug therapy / Q000662:veterinary*; D012867:Skin / Q000469:parasitology; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy*
D007306:Insecticides; D007783:Lactones; D007559:Ivermectin