Molecular analysis of the anti-GAT repertoire in three strains of mice.
GAT-specific antibodies which express the CGAT (or pGAT) public idiotypic specificities are encoded by a paucigene system. Antibodies expressing discrete specificities, i.e. anti-GAT and anti-NP, appeared to use the same VH germ-line genes, an observation which directly supports the importance of random H-L pairing to generate a large number of distinct antibody molecules.
D000595:Amino Acid Sequence; D000818:Animals; D007143:Immunoglobulin Heavy Chains / Q000032:analysis; D007130:Immunoglobulin Idiotypes / Q000032:analysis*; D007147:Immunoglobulin Light Chains / Q000032:analysis; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology*; D010455:Peptides / Q000276:immunology*; D011108:Polymers
D007143:Immunoglobulin Heavy Chains; D007130:Immunoglobulin Idiotypes; D007147:Immunoglobulin Light Chains; D010455:Peptides; D011108:Polymers; C020749:GAT