title: Quantitative evaluation of clinical course in surgical ICU patients: the data conform to catastrophe theory.
abstract: A response surface for critically ill patients is described. The coordinates of the three-dimensional response surface are two control variables, or state variables, related to aerobic and anaerobic metabolism, and a response variable, the A-VO2 difference. The data conform to a cusp catastrophe manifold. Cardiac insufficiency, adaptive response to stress, and sepsis may be distinguished by this model. The distinction between control and response variables is discussed.
mesh_terms: D000332:Aerobiosis; D000693:Anaerobiosis; D002245:Carbon Dioxide / Q000097:blood; D002388:Catastrophic Illness / Q000145:classification* / Q000628:therapy; D003422:Critical Care; D004734:Energy Metabolism; D006439:Hemodynamics; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological; D010100:Oxygen / Q000097:blood; D010347:Patient Care Planning
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen