[Toxicological studies on a new cephamycin, MT-141. X. Its perinatal and postnatal test in rats].
A perinatal and postnatal study of MT-141 was performed in SD rats. The dams were administered intramuscularly (i.m.) with MT-141 at the dose levels of 400, 800 and 1,600 mg/kg/day from the day 17 of gestation until the day 21 post delivery. The results are summarized as follows. No significant adverse effects of MT-141 were observed on the body weight gain, food consumption and water intake in dams of all groups treated with the drug during the perinatal and postnatal period. MT-141 did not change parameters of reproductive study in birth, development, physiological function and behavior of F1 rat. This compound had no effect on the fertility in F1 rats and also did not caused significant defects in the external appearance, viscera and skeleton of fetuses from dams (F1). It is concluded from these results that the maximal "no effective" dose of MT-141 is above 1,600 mg/kg/day i.m. for dams and the offsprings.
D000818:Animals; D001724:Birth Weight / Q000187:drug effects; D002513:Cephamycins / Q000494:pharmacology*; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005306:Fertilization / Q000187:drug effects*; D007743:Labor, Obstetric / Q000187:drug effects; D008099:Liver / Q000033:anatomy & histology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D002513:Cephamycins; C046079:cefminox