title: Induction of suppressor cells in mice following Vaccinia virus infection.
abstract: Infection of mice with Vaccinia virus produced suppression of responsiveness of spleen cells to mitogens in vitro and suppression of delayed-type hypersensitivity in vivo. The latter suppression was transferred to normal mice by spleen cells of virus-infected mice. The data presented show that Vaccinia virus-induced immunosuppression involves the induction of suppressor cells which belong to both the adherent and non-adherent cell fractions.
mesh_terms: D000818:Animals; D006968:Hypersensitivity, Delayed; D007108:Immune Tolerance; D008213:Lymphocyte Activation; D017710:Lymphocyte Transfusion; D051379:Mice; D008807:Mice, Inbred BALB C; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014184:Transplantation, Homologous; D014615:Vaccinia / Q000276:immunology*