Is gold necessary in so called chrysotherapy?
It is postulated that the efficacy of sodium aurothiomalate and d-penicillamine could be partly dependent on the activity of sulphydryl groups. Free thiomalate, the thiol from sodium aurothiomalate was shown to be liberated in vivo and has been detected in the blood and urine of sodium aurothiomalate-treated patients. An increase in intracellular glutathione levels in response to treatment with sodium aurothiomalate and penicillamine was demonstrated and considered to be related to these drugs' properties as thiols. A pilot clinical trial using sodium thiomalate treatment demonstrated clinical improvement in four out of six patients after one course. Two patients relapsed but both improved after a second course and there were no serious adverse reactions. It is concluded that although larger controlled clinical trials are required, the role of gold in "chrysotherapy" must remain in question.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002250:Carbon Radioisotopes; D002986:Clinical Trials as Topic; D006052:Gold Sodium Thiomalate / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D007273:Injections, Intramuscular; D007700:Kinetics; D051379:Mice; D010396:Penicillamine / Q000378:metabolism / Q000627:therapeutic use*; D051381:Rats; D013329:Structure-Activity Relationship; D014018:Tissue Distribution
D000893:Anti-Inflammatory Agents; D002250:Carbon Radioisotopes; D006052:Gold Sodium Thiomalate; D010396:Penicillamine