Is the cardiovascular effect of nitroglycerin related to the prostaglandin system in the dog?
Open-chest dogs were used for studies of the effects of intra-coronary (0.3-10 micrograms) or i.v. nitroglycerin (0.3-100 micrograms/kg) on systemic blood pressure (SBP), heart rate, left ventricular (LV) pressure, coronary blood flow and vascular resistance in the absence of presence of indomethacin (3 mg/kg i.v.). The nitroglycerin-induced changes in the cardiovascular parameters were not significantly modified by indomethacin (3 mg/kg i.v.). The dose of indomethacin used was large enough to inhibit significantly, for more than 2 h, the coronary vasodilation induced by arachidonic acid (100 micrograms) administered intra-arterially. The present study suggests that the cardiovascular action of nitroglycerin may not be mediated through the prostaglandin system.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology*; D011453:Prostaglandins / Q000502:physiology*; D014655:Vascular Resistance / Q000187:drug effects
D011453:Prostaglandins; D005996:Nitroglycerin; D007213:Indomethacin