title: Synthesis and pharmacological evaluation of a series of analgesic and antiinflammatory 4-aminopyrroles.
abstract: The synthesis and the pharmacological evaluation of a series of analgesic, antiinflammatory beta-aminopyrroles is described. Qualitative structure activity relationships are discussed. One of the compounds reported in the study is a candidate for toxicological and clinical trials.
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors; D001169:Arthritis, Experimental / Q000188:drug therapy; D002351:Carrageenan; D055598:Chemical Phenomena; D002621:Chemistry; D003967:Diarrhea / Q000188:drug therapy; D004487:Edema / Q000188:drug therapy; D007928:Lethal Dose 50; D008297:Male; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D014456:Ulcer / Q000139:chemically induced
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D011758:Pyrroles; D016718:Arachidonic Acid; D002351:Carrageenan