Influence of mithramycin on some platelet functions in vitro.
Platelet-rich plasma was incubated with mithramycin in vitro. This diminished platelet aggregation by ADP and adrenaline, but did not interfere with collagen-induced aggregation. Platelet factor 4 release was diminished by ADP and delayed when induced by adrenaline but normal when induced by collagen. Platelet factor 3 availability was not significantly impaired. Reptilase clot retraction was diminished when induced by ADP but normal when induced by collagen. Uptake of 14C-serotonin and 14C-adenine was slightly inhibited. There was no depression in platelet adhesion or release of serum aggregating activity.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001780:Blood Coagulation Tests; D002462:Cell Membrane / Q000187:drug effects; D003094:Collagen / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects*; D010977:Platelet Factor 3 / Q000502:physiology; D010978:Platelet Factor 4 / Q000502:physiology; D008926:Plicamycin / Q000494:pharmacology*
D010977:Platelet Factor 3; D010978:Platelet Factor 4; D000244:Adenosine Diphosphate; D003094:Collagen; D008926:Plicamycin; D004837:Epinephrine