DNA content in reactive hyperplasia, precancerosis, and carcinomas of the oral cavity. A cytophotometric study.
Cytophotometry has been used to study DNA content in oral epithelial cells of Feulgen-stained specimens from a total of 43 patients: 3 with erythema exudativum multiforme (EEM), 5 with pemphigus, 3 with stomatitis aphtosa, 5 with lichen ruber planus, 8 with leukoplakia, and 19 with carcinomas. In contrast to reactive hyperplasia (EEM, pemphigus, stomatitis aphthosa) leukoplakia has histograms closest to those of carcinoma, with a high percentage of cells in the polyploid regions. This emphasizes the significance of cytophotometry for diagnosis of preneoplastic and neoplastic lesions of the oral cavity.
D004247:DNA / Q000032:analysis*; D004273:DNA, Neoplasm / Q000032:analysis; D004848:Epithelium / Q000032:analysis; D006801:Humans; D006965:Hyperplasia; D007972:Leukoplakia, Oral / Q000032:analysis*; D009055:Mouth / Q000032:analysis* / Q000473:pathology; D009062:Mouth Neoplasms / Q000032:analysis*
D004273:DNA, Neoplasm; D004247:DNA