title: [Diurnal changes in the lysosomal enzyme activity of the liver of mice and rats].
abstract: Lysosomal enzymes acid phosphatase, acid DNAase, acid RNAase cathepsin D,beta-galactosidase beta-glucuronidase were studied in mice and rat liver tissue within 3 days beginning from 4 o'clock a.m. at 4 hrs intervals. Activities of acid phosphatase, acid RNA ase in mice liver tissue and of cathepsin D in rat and mice liver tissues was higher at morning and day time than at evening and night. Alterations in enzymatic activity of non-sedimenting fraction of mice liver tissue correlated with that of total activity. In non-sedimenting fraction of rat liver tissue the enzymatic activity was altered only slightly. Within the second half of a day the enzymatic activity redistributed in the cells with an increase of the activity in non-sedimenting fraction, caused by labilization of lysosomal membranes.
mesh_terms: D000135:Acid Phosphatase / Q000502:physiology; D000818:Animals; D002402:Cathepsin D; D002403:Cathepsins / Q000502:physiology; D002940:Circadian Rhythm; D003851:Deoxyribonucleases / Q000502:physiology; D005260:Female; D006867:Hydrolases / Q000502:physiology*; D008099:Liver / Q000201:enzymology* / Q000648:ultrastructure; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D051379:Mice; D051381:Rats; D012260:Ribonucleases / Q000502:physiology; D001616:beta-Galactosidase / Q000502:physiology; D001617:beta-Glucosidase / Q000502:physiology
chemical_list: D006867:Hydrolases; D003851:Deoxyribonucleases; D012260:Ribonucleases; D000135:Acid Phosphatase; D001617:beta-Glucosidase; D001616:beta-Galactosidase; D002403:Cathepsins; D002402:Cathepsin D
vernacular_title: Sutochnye izmeneniia aktivnosti lizosomal'nykh fermentov v pecheni mysheĭ i krys.