The continuous and quantitative observation of permeability changes of the blood-aqueous barrier in allergic inflammation of the eye.
Permeability changes of the blood-aqueous barrier were studied in the eyes of rabbits subjected to immunologic inflammation. The changes were investigated by slit-lamp microphotometers. The leakage of fluorescein-labeled rabbit serum albumin into the anterior chamber was observed in eyes inflamed by reverse passive Arthus reactions. The permeability of the blood-aqueous barrier changed in biphasic pattern in allergic inflammations; the first phase began 5 min after the antigen challenge and lasted for 1 hr, followed by the late phase at which the dye concentration reached a peak 2 hr after the challenge and then gradually decreased.
D000818:Animals; D000937:Antigen-Antibody Reactions; D001082:Aqueous Humor / Q000032:analysis / Q000502:physiology*; D001183:Arthus Reaction / Q000503:physiopathology*; D001825:Body Fluid Compartments; D005128:Eye Diseases / Q000276:immunology; D010539:Permeability; D011398:Promethazine / Q000494:pharmacology; D011817:Rabbits
D011398:Promethazine