The effect of the anabolic steroid stanozolol on tissue plasminogen activator activity and plasmin inhibition in the rat.
The anabolic steroid stanozolol administered orally in male Sprague-Dawley rats induced a dose- and time-dependent increase in tissue plasminogen activator activity. The increase was highest in lung, lowest in heart, and intermediate in aorta and kidney. A slight increase in plasmin inhibition was noted only in the heart.
D000375:Aging; D000818:Animals; D001011:Aorta / Q000254:growth & development / Q000378:metabolism; D005341:Fibrinolysin / Q000037:antagonists & inhibitors*; D006321:Heart / Q000254:growth & development; D007668:Kidney / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010960:Plasminogen Activators / Q000378:metabolism*; D051381:Rats; D013197:Stanozolol / Q000494:pharmacology*
D013197:Stanozolol; D010960:Plasminogen Activators; D005341:Fibrinolysin