[Thyrotrophin releasing hormone (TRH) stimulates the secretion of T4 by perfused thyroid fragments from rats].
Evidence of a direct stimulating effect of TRH on T4 secretion was found by using the perifusion technique on Rat thyroid fragments. A dose-response curve was plotted and the kinetic pattern of the response was studied.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D007700:Kinetics; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D013974:Thyroxine / Q000378:metabolism*
D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine
La thyrotrophin releasing hormone (TRH) stimule la sécrétion de T4 par des fragments de thyroïdes de rats en perifusion.