title: Radiographic evaluation of erosion in rheumatoid arthritis: double blind study of auranofin vs placebo.
abstract: PA radiographs of hands and wrists from a randomized 6 month study of auranofin (AF) vs placebo followed by 6 months of open AF were scored for progression of erosive disease by 2 independent readers. The readers were blinded both to treatment and sequence (month 0 vs month 12) of the films. The results of our study demonstrate a reduction in the advancement of erosive disease during AF therapy compared to placebo.
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging / Q000188:drug therapy*; D001175:Arthrography; D001310:Auranofin; D006051:Aurothioglucose / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006046:Gold / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D006051:Aurothioglucose; D001310:Auranofin; D006046:Gold