Gentamicin nephrotoxicity in cadmium, lead and mercury pretreated rats.
The effect of a previous chronic exposure to cadmium, lead or inorganic mercury on the nephrotoxic potential of gentamicin was investigated in female Sprague-Dawley rats. A daily dose of 10 mg gentamicin/kg body weight/day was administered for 21 days to rats having a renal load of 168 micrograms Cd, 35 micrograms Pb or 129 micrograms Hg/g whole kidney. Urine analysis suggests an attenuation of the nephrotoxic potential of gentamicin while a microscopical examination of kidneys indicates a superimposition of the effects of the metals and the antibiotics. The only clear interaction observed consists in a reduction of gentamicin accumulation in the cortex of cadmium-treated animals. It is concluded that none of the metal pretreatments potentiates the nephrotoxic effects of gentamicin.
D000596:Amino Acids / Q000652:urine; D000818:Animals; D002105:Cadmium Poisoning / Q000378:metabolism* / Q000473:pathology; D004347:Drug Interactions; D005260:Female; D005839:Gentamicins / Q000378:metabolism / Q000633:toxicity*; D007672:Kidney Cortex / Q000201:enzymology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D007855:Lead Poisoning / Q000378:metabolism* / Q000473:pathology; D008630:Mercury Poisoning / Q000378:metabolism* / Q000473:pathology; D009994:Osmolar Concentration; D010743:Phospholipids / Q000378:metabolism; D011507:Proteinuria / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D001616:beta-Galactosidase / Q000652:urine
D000596:Amino Acids; D005839:Gentamicins; D010743:Phospholipids; D001616:beta-Galactosidase