Influence of diet on 1,2-dimethylhydrazine metabolism in rat liver.
The metabolism of 1,2-dimethylhydrazine (DMH) was investigated in isolated perfused livers excised from Sprague-Dawley rats fed four semisynthetic diets over two generations. The diets were varied within normal physiological limits, without producing specific deficiencies. Diet was shown to have an influence on the growth of animals and on the cholesterol content and beta-glucuronidase activity in the blood serum. However, diet did not influence the rate of metabolism of DMH or the concentration of metabolites.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens / Q000378:metabolism*; D004032:Diet; D004040:Dietary Carbohydrates / Q000494:pharmacology; D004041:Dietary Fats / Q000494:pharmacology; D004044:Dietary Proteins / Q000494:pharmacology; D004127:Dimethylhydrazines / Q000378:metabolism*; D008099:Liver / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008763:Methylhydrazines / Q000378:metabolism*; D009929:Organ Size / Q000187:drug effects; D011502:Protein-Energy Malnutrition / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; D004040:Dietary Carbohydrates; D004041:Dietary Fats; D004044:Dietary Proteins; D004127:Dimethylhydrazines; D008763:Methylhydrazines