[Toxicological studies on a new cephamycin, MT-141. VII. Its locally-irritating activity in rabbits].
The local irritation of MT-141 was compared with that of cefmetazole (CMZ) in rabbits to obtain following results. Microscopic observations revealed that the irritative activity of 10% solution of MT-141 in blood vessels was not so much different from that of saline and 10% solution of CMZ when they were injected twice a day into vein retroauricularis of rabbits for 7 days. The histopathological changes induced by 10% solution of MT-141 were similar to those by 10% solution of CMZ but somewhat different from those by saline, because both compounds caused slight necrosis in the tissue around vessels. Histopathological observations suggested that the occurrence of necrosis was due to the leakage of them during injections. The local irritation of MT-141 by an injection of 1 ml of its solution into muscle vastus lateralis was compared with that of CMZ in rabbits. The potencies of irritative activity of the test solutions were summarized in the following order; saline less than 5% MT-141 less than 10% MT-141 not equal to 10% CMZ much less than 0.75% acetic acid less than 6.0% acetic acid. The above-mentioned results suggest that MT-141 has low irritating activity when injected through intravenous or intramuscular route for clinical practice as 5% or 10% solution.
D000818:Animals; D015311:Cefmetazole; D002513:Cephamycins / Q000633:toxicity*; D004431:Ear, External / Q000098:blood supply; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D011817:Rabbits; D013927:Thrombosis / Q000139:chemically induced / Q000473:pathology
D002513:Cephamycins; D015311:Cefmetazole; C046079:cefminox