Effect of nomifensine on the toxicity of 6-hydroxydopamine for mesotelencephalic dopamine neurons.
The ability of nomifensine to protect the dopaminergic cells of the substantia nigra and ventral tegmental areas against 6-hydroxydopamine-induced destruction was evaluated. Nomifensine at high doses (20 mg/kg, i.p.) protected the cells from the effects of low amounts of 6-hydroxydopamine (2 micrograms) injected intracerebrally. This protective effect was markedly decreased with an increased amount of 6-hydroxydopamine (8 micrograms), or by lower doses of nomifensine (6.7 mg/kg). These doses of nomifensine are higher than those required to protect dopaminergic nerve terminals.
D000818:Animals; D004298:Dopamine / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000633:toxicity*; D007276:Injections, Intraventricular; D007546:Isoquinolines / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009627:Nomifensine / Q000494:pharmacology*; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*; D013687:Telencephalon / Q000187:drug effects / Q000502:physiology*
D006892:Hydroxydopamines; D007546:Isoquinolines; D009627:Nomifensine; D016627:Oxidopamine; D004298:Dopamine