Effects of the selective noradrenergic neurotoxin DSP4 on cerebellar Purkinje neuron electrophysiology.
The effect of the adrenergic neurotoxin DSP4 on cerebellar electrophysiology was studied in the rat. DSP4, administered parenterally, depleted cerebellar norepinephrine by 76%. The depressant response of cerebellar Purkinje neurons to phencyclidine, a drug which acts on adrenergic presynaptic terminals to release NE, was markedly reduced after DSP4 pretreatment. In contrast with 6OHDA, which increased firing rates of the Purkinje cells, DSP4 did not change the rate or pattern of Purkinje cell discharge. Taken together these results suggest that DSP4 may be a valuable tool for studying central adrenergic pathways, but that this drug has properties which differ from 6OHDA.
D000588:Amines / Q000494:pharmacology*; D000818:Animals; D001596:Benzylamines / Q000494:pharmacology*; D002531:Cerebellum / Q000032:analysis; D004594:Electrophysiology / Q000187:drug effects; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D009498:Neurotoxins / Q000494:pharmacology*; D009638:Norepinephrine / Q000032:analysis / Q000502:physiology; D016627:Oxidopamine; D011689:Purkinje Cells / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D000588:Amines; D001596:Benzylamines; D006892:Hydroxydopamines; D009498:Neurotoxins; D016627:Oxidopamine; C012102:DSP 4; D009638:Norepinephrine