title: Acquired resistance to cancer chemotherapy.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000627:therapeutic use*; D004351:Drug Resistance; D006801:Humans; D008727:Methotrexate / Q000378:metabolism; D051379:Mice; D008954:Models, Biological; D009154:Mutation; D009369:Neoplasms / Q000378:metabolism
chemical_list: D000970:Antineoplastic Agents; D008727:Methotrexate