title: [The OLA major histocompatibility complex of sheep. Genetic frequencies compared in Prélpe sheep with and without scrapie].
abstract: The OLA genic frequencies were studied in both normal "Préalpe" Sheep and those affected with Scrapie. In the non-affected Sheep of contaminated flocks, frequencies were generally decreased, compared with frequencies of the same factors in sick Sheep or in non-infected controls. Three OLA-A genes significantly decreased; at this locus, results in "Préalpe" and "Ile-de-France" Sheep were inversed. This observation excludes OLA genes being involved in pathogeny or resistance to the disease, but suggests the existence of a linkage between the OLA loci and at least one resistance or susceptibility locus.
mesh_terms: D000818:Animals; D005787:Gene Frequency; D007113:Immunity, Innate; D008285:Major Histocompatibility Complex; D012608:Scrapie / Q000235:genetics* / Q000276:immunology; D012756:Sheep / Q000235:genetics* / Q000276:immunology
vernacular_title: Le complexe majeur d'histocompatibilité OLA des ovins. Fréquences géniques comparées chez des moutons Préalpes atteints ou non de tremblante (scrapie).