[Sorbitol pathway of glucose metabolism in streptozotocin diabetes of varying duration and severity].
The degree of accumulation of sorbitol pathway metabolites by the lens, sciatic nerve and aorta is determined by the duration and gravity of experimental diabetes. As the blood glucose content (indicating experimental diabetes gravity) rises, the aldose reductase activity in the tissues increases, the content of sorbitol and fructose ascends. The sorbitol-dehydrogenase activity does not depend on diabetes gravity. An increase of aldose reductase and a decrease in the sorbitol-dehydrogenase activity occur within the first two weeks after diabetes induction, which correlates with the maximal rate of sorbitol and fructose accumulation. The conclusion is made on the necessity of a strict compensation for diabetes to prevent the development of chronic complications.
D000449:Aldehyde Reductase / Q000378:metabolism; D000818:Animals; D001011:Aorta / Q000378:metabolism; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005632:Fructose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D007064:L-Iditol 2-Dehydrogenase / Q000378:metabolism; D007908:Lens, Crystalline / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000378:metabolism; D013012:Sorbitol / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution
D001786:Blood Glucose; D005632:Fructose; D013012:Sorbitol; D007064:L-Iditol 2-Dehydrogenase; D000449:Aldehyde Reductase; D005947:Glucose
Sorbitolovyĭ put' obmena gliukozy pri streptozototsinovom diabete raznoĭ dlitel'nosti i tiazhesti.