Characterization of the b99 allotype of rabbit immunoglobulin kappa 1 light chain.
A previously undetected allotypic specificity, A99, was found in a wild rabbit (Oryctolagus cuniculus) population in Portugal. The A99 allotype cross-reacted with anti-b6 and anti-b96 sera, but carried its own antigenic determinants and was therefore distinct from the known allotypes of the b series. The A99 determinants were located on the kappa 1 light chain of IgG molecules and were inherited as allotypic determinants of the b series. Taken together, these data provide evidence that A99 is encoded by an allele at the b locus, tentatively designated b99. The great similarity between the b6, b96 and b99 allotypes suggests that they derived from a common ancestor.
D000818:Animals; D000829:Animals, Domestic; D000835:Animals, Wild; D000936:Antigen-Antibody Complex; D003433:Crosses, Genetic; D005260:Female; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D007074:Immunoglobulin G / Q000235:genetics; D007147:Immunoglobulin Light Chains / Q000235:genetics*; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D008297:Male; D010375:Pedigree; D010641:Phenotype; D011174:Portugal; D011817:Rabbits / Q000276:immunology*
D000936:Antigen-Antibody Complex; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains