Identification of an envelope mutation (env-10) resulting in increased antibiotic susceptibility and pyocin resistance in a clinical isolate of Neisseria gonorrhoeae.
A mutation (env-10) conferring increased susceptibility to drugs, dyes, and detergents was detected in a clinical isolate of Neisseria gonorrhoeae. In certain strains, env-10 also affected susceptibility to pyocins. This mutation was phenotypically similar to but genotypically distinct from previously described env mutations.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001430:Bacteriocins / Q000494:pharmacology*; D002462:Cell Membrane; D002473:Cell Wall; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests; D009154:Mutation; D009344:Neisseria gonorrhoeae / Q000187:drug effects / Q000235:genetics* / Q000648:ultrastructure; D011709:Pyocins / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D011709:Pyocins