Retinoic acid enhances the growth of only one subpopulation of granulomonocyte precursors.
The effect of various concentrations of retinoic acid on the growth of committed granulomonopoietic precursors (CFU-GM) was studied on semisolid agar cultures. Retinoic acid increased the growth of day 14 CFU-GM but had no significant effect on day 7 CFU-GM. Since the latter are believed to represent the progeny of day 14 CFU-GM it is suggested that the effect of retinoic acid is confined to the early stages of granulomonocytic differentiation.
D001854:Bone Marrow Cells; D002454:Cell Differentiation / Q000187:drug effects; D003114:Colony-Forming Units Assay; D006098:Granulocytes / Q000166:cytology; D006412:Hematopoietic Stem Cells / Q000145:classification / Q000166:cytology*; D006801:Humans; D009000:Monocytes / Q000166:cytology; D013997:Time Factors; D014212:Tretinoin / Q000494:pharmacology*
D014212:Tretinoin