title: fluoropyrimidine-induced antagonism to free and tightly bound methotrexate: suppression of [14C] formate incorporation into RNA and protein.
mesh_terms: D000818:Animals; D002250:Carbon Radioisotopes; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D004273:DNA, Neoplasm / Q000096:biosynthesis; D003857:Deoxyuridine / Q000378:metabolism; D005467:Floxuridine / Q000494:pharmacology*; D005561:Formates / Q000378:metabolism; D008727:Methotrexate / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D051379:Mice; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D012334:RNA, Neoplasm / Q000096:biosynthesis*
chemical_list: D002250:Carbon Radioisotopes; D004273:DNA, Neoplasm; D005561:Formates; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm; D005467:Floxuridine; D003857:Deoxyuridine; D008727:Methotrexate