[Comparative in vitro activity of 5 beta-lactams (cefoperazone, cefsulodin, ceftazidime, azthreonam, N-formimidoyl-thienamycin) on 90 strains of Pseudomonas aeruginosa with various levels of resistance to ticarcillin].
Five beta-lactams with anti-pseudomonal activity were tested against P. aeruginosa strains resistant to various concentrations of ticarcillin (from 256 to 8192 mg/l). MIC geometric means found for the totality of strains were as follows: 1.52 mg/l for ceftazidime; 1.80 mg/l for N-f-thienamycin; 4.79 mg/l for azthreonam; 17.3 mg/l for cefsulodin; 50.9 mg/l for cefoperazone. Activities of ceftazidime, N-f-thienamycin and azthreonam were not related to the level of ticarcillin resistance. Cefoperazone and, to a lesser degree, cefsulodin showed cross resistance with ticarcillin: these drugs were not active when ticarcillin MICs reached 512 mg/l and 4 096 mg/l respectively.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001398:Aztreonam; D002438:Cefoperazone / Q000494:pharmacology; D002441:Cefsulodin; D002442:Ceftazidime; D002511:Cephalosporins / Q000494:pharmacology; D015378:Imipenem; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013845:Thienamycins / Q000494:pharmacology; D013982:Ticarcillin / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010406:Penicillins; D013845:Thienamycins; D015378:Imipenem; D002438:Cefoperazone; D002442:Ceftazidime; D013982:Ticarcillin; D001398:Aztreonam; D002441:Cefsulodin
Activité comparée in vitro de cinq bêtalactamines (céfoperazone, cefsulodine, ceftazidime, azthréonam, N-formimidoyl-thiénamycine) sur 90 souches de Pseudomonas aeruginosa présentant différents niveaux de résistance à la ticarcilline.