title: Failure of large tidal volumes to improve oxygen availability during anaesthesia.
abstract: Eight patients undergoing peripheral vascular surgery were ventilated with small (5.3 ml/kg) and large (16.3 ml/kg) tidal volumes at a constant respiratory rate. Carbon dioxide was added to the inspired gases to maintain normal end-tidal levels. The use of large tidal volumes resulted in a significant increase in arterial oxygen tension and content, but, due to a reduction in cardiac output, failed to improve oxygen availability.
mesh_terms: D000368:Aged; D000769:Anesthesia, Inhalation; D002245:Carbon Dioxide / Q000032:analysis; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000032:analysis / Q000502:physiology*; D010313:Partial Pressure; D012121:Respiration, Artificial; D013990:Tidal Volume
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen