[Simultaneous increase in the aromatization of testosterone into estrogens and secretion of inhibin by Sertoli cells in culture].
17 beta oestradiol and inhibin production by Sertoli cells has been investigated in vitro. In basal conditions, 17 beta-oestradiol secretion is weak whereas inhibin production is undetectable on days 7 and 9 of culture. Addition of PMSG (FSH-like gonadotrophin) and testosterone to the culture medium induces a simultaneous increase in 17 beta-oestradiol and inhibin production. PMSG alone has no effect neither on inhibin nor on 17 beta-oestradiol secretion. Testosterone alone significantly increases 17 beta-oestradiol and inhibin production. Human chorionic gonadotrophin (LH-like gonadotrophin) does not modify inhibin secretion. Dihydrotestosterone stimulates inhibin production without affecting oestrogens secretion. Thus, stimulation of aromatization of testosterone into 17 beta-oestradiol is associated with an increase of inhibin production, but this effect seems to be due to a direct action of androgens.
D000818:Animals; D002478:Cells, Cultured; D004958:Estradiol / Q000096:biosynthesis*; D006064:Gonadotropins, Equine / Q000494:pharmacology; D007265:Inhibins; D008297:Male; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D012708:Sertoli Cells / Q000378:metabolism*; D013735:Testicular Hormones / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism* / Q000494:pharmacology
D006064:Gonadotropins, Equine; D011506:Proteins; D013735:Testicular Hormones; D013739:Testosterone; D004958:Estradiol; D007265:Inhibins
Augmentation simultanée de l'aromatisation de la testostérone en oestrogènes et de la sécrétion d'inhibine par les cellules de Sertoli en culture.