The hepatocarcinogenicity of diethylnitrosamine to rainbow trout and its enhancement by Aroclors 1242 and 1254.
Rainbow trout (Salmo gairdneri) were fed diets containing 100 ppm Aroclor 1242 (AC42) or Aroclor 1254 (AC54) in combination with 1100 ppm diethylnitrosamine (DEN) for one year. The incidence of hepatocarcinomas was determined and compared with the incidence in trout fed 1100 ppm DEN alone. The two Aroclors dramatically enhanced tumor incidence from 10.2% in the positive controls (DEN alone) to 40.2% for AC42 and 21.6% for AC54. This is in contrast to previous results obtained when AC54 was fed concomitantly with aflatoxin B1 (AFB1), where a substantial inhibition of carcinogenesis was observed. The alteration of chemical carcinogenesis in trout by PCB, therefore, depends upon the carcinogen involved and is not a generalized effect.
D000284:Administration, Oral; D000818:Animals; D001140:Aroclors / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D020111:Chlorodiphenyl (54% Chlorine); D004052:Diethylnitrosamine / Q000633:toxicity*; D004347:Drug Interactions; D008099:Liver / Q000187:drug effects; D008113:Liver Neoplasms / Q000139:chemically induced*; D009602:Nitrosamines / Q000633:toxicity*; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D014337:Trout
D001140:Aroclors; D002273:Carcinogens; D009602:Nitrosamines; D020111:Chlorodiphenyl (54% Chlorine); D004052:Diethylnitrosamine; C027423:aroclor 1242; D011078:Polychlorinated Biphenyls