title: A new perfusion circuit for the newborn with lung immaturity: extracorporeal CO2 removal via an umbilical arteriovenous shunt during apneic O2 diffusion.
abstract: In spite of improved prophylaxis and therapy, the respiratory distress syndrome is still a major cause of morbidity and mortality in premature babies. Owing to the fact that a number of patients are unresponsive to other methods of neonatal care, an increasing number of perinatal centers have started to treat this group of patients with extracorporeal membrane oxygenation successfully. To make the extracorporeal gas exchange more practicable for the neonate directly after birth, a modification of this method using an umbilical arteriovenous shunt for CO2 removal in apneic premature lambs as an animal model was evaluated. A miniaturized low-resistance extracorporeal circuit that is totally incorporated in a regular intensive care baby incubator was developed. The benefit of using extracorporeal CO2 removal in very low birth weight newborns could be a conditioning of the premature lung during a short period of bypass, after which ventilation at nontraumatic pressures and nontoxic O2 concentrations would become possible.
mesh_terms: D000818:Animals; D001049:Apnea / Q000097:blood / Q000628:therapy; D001166:Arteriovenous Shunt, Surgical; D002245:Carbon Dioxide / Q000097:blood*; D005112:Extracorporeal Circulation / Q000379:methods*; D005325:Fetal Organ Maturity; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000196:embryology; D010107:Oxygenators, Membrane; D012127:Respiratory Distress Syndrome, Newborn / Q000097:blood / Q000628:therapy*; D012756:Sheep; D014469:Umbilical Arteries / Q000601:surgery; D014471:Umbilical Veins / Q000601:surgery
chemical_list: D002245:Carbon Dioxide