Anxiogenic action of benzodiazepine antagonists Ro 15-1788 and CGS 8216 in the rat.
Ro 15-1788 and CGS 8216 are potent inhibitors of benzodiazepine (BDZ) binding in vitro and may antagonize BDZ effects in vivo. These compounds are less well characterized behaviorally, but, as BDZ antagonists, anxiety-producing (anxiogenic) effects may be hypothesized. This hypothesis was investigated using a conditioned spatial aversion test of anxiety in the rat. Both compounds produced an increase in spatial aversion. This may suggest that these compounds are potentially anxiogenic. The results of these experiments further suggest that the conditioned spatial aversion test may be sensitive to a range of compounds with demonstrable BDZ receptor affinity.
D000818:Animals; D001007:Anxiety; D001569:Benzodiazepines / Q000037:antagonists & inhibitors*; D001570:Benzodiazepinones / Q000494:pharmacology*; D003292:Convulsants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005442:Flumazenil; D006801:Humans; D008297:Male; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D001570:Benzodiazepinones; D003292:Convulsants; D011720:Pyrazoles; D001569:Benzodiazepines; D005442:Flumazenil; C033830:2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one