A long-term study of the epididymal- and fertility-suppressing effects of cyproterone acetate in the mouse.
The influence of cyproterone acetate (CA) (0.1 mg/mouse/day) on the epididymis and male fertility was analyzed in a long-term study in the Swiss albino cc strain. CA inhibits epididymal function in all segments as measured by organ weights, protein content and beta-glucuronidase activity. This antiandrogen also suppresses male fertility. It is important to note that the low dose of CA, used in this study, does not affect spermatogenesis. The effects of CA on epididymis and fertility are reversible and the magnitude of recovery or the period (in days) required for a significant recovery after the discontinuation of CA were seemingly directly proportional to the duration of antiandrogen treatment.
D000818:Animals; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017373:Cyproterone Acetate; D013196:Dihydrotestosterone / Q000494:pharmacology; D004822:Epididymis / Q000187:drug effects / Q000502:physiology*; D005298:Fertility / Q000187:drug effects*; D005966:Glucuronidase / Q000378:metabolism; D007248:Infertility, Male / Q000139:chemically induced*; D007700:Kinetics; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011506:Proteins / Q000378:metabolism
D011506:Proteins; D013196:Dihydrotestosterone; D017373:Cyproterone Acetate; D003534:Cyproterone; D005966:Glucuronidase