Rat strain differences in brain monoamine metabolism following para-chlorophenylalanine treatment.
The effect of parachlorophenyllalanine (PCPA) on 5-hydroxytryptamine (5-HT) was studied in sham-operated and castrated rats of two different rat strain. PCPA was more effective in depressing the brain 5-HT levels in Wistar (W) rats than in Sprague Dawley (SD) rats.
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002369:Castration; D003864:Depression, Chemical; D004298:Dopamine / Q000378:metabolism; D010134:Fenclonine / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013045:Species Specificity
D001679:Biogenic Amines; D012701:Serotonin; D010134:Fenclonine; D004298:Dopamine; D009638:Norepinephrine