title: Altered brain metabolism of testosterone is correlated with reproductive decline in aging quail.
abstract: In aging quail, an increasing proportion of males show no sexual behavior. A decrease in the mean size of the tests, cloacal gland, and sternotracheal muscles is also observed. In both sexually active and inactive males, plasma testosterone decreases with age but more so in inactive birds. The behavioral and morphological changes observed during aging are correlated with shifts in the intracellular testosterone metabolism resulting in a change in the ratio of active versus inactive metabolites. In the hypothalamus there is a steady decrease with age of 5 beta-reductase activity in all birds and an increase in 5 alpha-reductase activity only in the birds which remain sexually active. In the cloacal gland, the 5 beta-reductase activity markedly increases with age but more so in the birds which become sexually inactive. These data support the notion that the effects of testosterone are controlled by enzymatic shifts which could modulate the sensitivity to the hormone at the cellular level.
mesh_terms: D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000378:metabolism; D000375:Aging; D000731:Androstanes / Q000097:blood; D000735:Androstenedione / Q000097:blood; D000818:Animals; D001711:Biotransformation; D001921:Brain / Q000201:enzymology*; D003307:Copulation / Q000502:physiology; D003370:Coturnix; D013196:Dihydrotestosterone / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D007034:Hypothalamus, Posterior / Q000201:enzymology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism; D010902:Pituitary Gland / Q000201:enzymology; D011301:Preoptic Area / Q000201:enzymology; D012726:Sexual Behavior, Animal / Q000502:physiology*; D013739:Testosterone / Q000097:blood*
chemical_list: D000731:Androstanes; D013196:Dihydrotestosterone; D013739:Testosterone; D000735:Androstenedione; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D010088:Oxidoreductases; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase; C021936:3-oxo-5 beta-steroid delta 4-dehydrogenase