title: Effect of particle size of dried mycobacteria on adjuvant induced arthritis in the rat.
abstract: Freund's complete adjuvant prepared by grinding dried, heat killed Mycobacterium tuberculosis with liquid paraffin was investigated for particle size-weight distribution. Variations in the grinding times and preparative procedure had a marked effect on the arthritogenic action of the adjuvant in the rat. A satisfactory response in the injected foot was found only when the particle size was less than 19 microns and a secondary response in the non-injected foot required particles less than 10 microns in diameter.
mesh_terms: D000818:Animals; D001168:Arthritis / Q000276:immunology*; D001169:Arthritis, Experimental / Q000276:immunology*; D005620:Freund's Adjuvant; D008297:Male; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D010316:Particle Size; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005620:Freund's Adjuvant