Additional evidence that the suprachiasmatic nucleus is the center for regulation of insulin secretion and glucose homeostasis.
The role of the suprachiasmatic nucleus (SCN) in photoperiod-dependent hyperglycemia due to D-mannitol (MA) and D-glucose (GL) was investigated using SCN-lesioned rats. In control rats, intracranial injection of MA and GL caused hyperglycemia only in the light period and dark period, respectively. In SCN-lesioned rats, administration of MA and GL caused no change in plasma glucose level, irrespective of the lighting condition. SCN-lesioned rats have higher plasma insulin levels than sham-operated rats through this experiment. From these findings, we propose that the SCN is involved in a glucose homeostasis and regulation of insulin secretion.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001931:Brain Mapping; D005947:Glucose / Q000494:pharmacology; D007026:Hypothalamic Area, Lateral / Q000502:physiology; D007033:Hypothalamus, Middle / Q000502:physiology; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008027:Light; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D010507:Periodicity; D051381:Rats; D011919:Rats, Inbred Strains; D013493:Suprachiasmatic Nucleus / Q000502:physiology*
D001786:Blood Glucose; D007328:Insulin; D008353:Mannitol; D005947:Glucose