[Stabilization of the relative concentration of ATP and invariants in the regulation of erythrocyte energy metabolism].
The problem is considered concerning the effect of individual differences of erythrocyte energetic metabolism parameters in the regulation (stablization) of ATP level. It has been found that equal quality of stabilization of relative ATP concentration (ATP/(AMP+ADP+ATP)) in erythrocytes with very different individual parameters is provided, firstly, by presence of scaling invariance of the characteristics of ATP-producing and ATP-consuming systems, and, secondly, by coincidence between the physiological values of ATP/(AMP+ADP+ATP) ratio for all the individuals. Scaling invariance property results in the essential reduction of the effective dimension of the individual parameters space. Revealed is a single parameter (function of all individual parameters), which defines the level of relative ATP concentration or the erythrocyte energy charge. The hypothesis is formulated that erythrocyte has two levels of energetic metabolism regulation, of which the first level is responsible for regulation of relative ATP concentration (due to the self-energy system functioning), while the second one provides (for a long time) regulation of the individual parameter values.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000249:Adenosine Monophosphate / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000096:biosynthesis / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006019:Glycolysis; D006801:Humans; D006868:Hydrolysis; D008433:Mathematics
D000249:Adenosine Monophosphate; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases
Stabilizatsiia otnositel'noĭ kontsentratsii ATF i invarianty reguliatsii énergeticheskogo metabolizma éritrotsita.