[Gold therapy in chronic polyarthritis. Differentiation of allergic and toxic side effects].
The data from 310 patients treated with gold were analysed. The occurrence of side effects is lower than the average data in the literature: with "Solganal" 21.5%, with "Tauredon" 21%. The clinical importance of the differentiation of toxic and allergic side effects is pointed out. It seems possible to differentiate between the toxic-allergic and the dosage dependent, actually toxic side effects. In cases of toxicity caused by retarded metabolisation the use of the barbiturate enzyme induction made it possible to continue treatment.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D006051:Aurothioglucose / Q000009:adverse effects*; D002648:Child; D003875:Drug Eruptions / Q000209:etiology; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006046:Gold / Q000009:adverse effects*; D006052:Gold Sodium Thiomalate / Q000009:adverse effects*; D006801:Humans; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D008875:Middle Aged
D000893:Anti-Inflammatory Agents; D006052:Gold Sodium Thiomalate; D006051:Aurothioglucose; D006046:Gold
Erfahrungen mit der Goldtherapie bei chronischer Polyarthritis. Unterscheidung der allergischen und toxischen Nebenwirkungen.