Evaluation of intravitreal 5-fluorouracil, vincristine, VP 16, doxorubicin, and thiotepa in primate eyes.
A single intravitreal dose of 750 micrograms 5 fluorouracil (5 FU) or 5 micrograms doxorubicin were nontoxic to primate eyes. A concentration of 250 micrograms/ml of 5 FU in the vitrectomy infusion fluid in combination with 8 micrograms/ml of thiotepa, with 40 micrograms/ml of VP16 (etoposide), or with either .04 or .02 microgram/ml of vincristine was also well tolerated by the primate eye. 5 micrograms/ml of doxorubicin in the vitrectomy infusion fluid did not cause apparent toxicity to the retina. Toxic effects were noted in eyes receiving 250 micrograms of 5 FU in combination with either .15 or .1 microgram/ml of vincristine.
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000633:toxicity; D004317:Doxorubicin / Q000633:toxicity*; D004596:Electroretinography; D005047:Etoposide / Q000633:toxicity*; D005472:Fluorouracil / Q000633:toxicity*; D008252:Macaca fascicularis; D011034:Podophyllotoxin / Q000031:analogs & derivatives*; D012160:Retina / Q000187:drug effects; D013852:Thiotepa / Q000633:toxicity*; D014750:Vincristine / Q000633:toxicity*; D014822:Vitreous Body / Q000187:drug effects*
D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D013852:Thiotepa; D011034:Podophyllotoxin; D005472:Fluorouracil