title: Comparison of the (pro)convulsive properties of fluvoxamine and clovoxamine with eight other antidepressants in an animal model.
abstract: Freely moving rats were implanted with cortical, caudal, thalamic, and reticular electrodes. Drugs were infused intravenously at a constant rate up to a final cumulative dose of 40, 50, or 60 mg/kg. Doses of 10 mg/kg imipramine, viloxazine, desmethylimipramine, mianserin, and maprotiline produced spike-wave complexes, spikes, and increased spindling. General sustained discharges occurred after 20 mg/kg of mianserin, viloxazine, imipramine, desmethylimipramine and amitriptyline, and after 30 mg/kg of maprotiline. An abnormal high-amplitude pattern was evident after mianserin, amitriptyline, imipramine, and desmethylimipramine. On the average, seizures were observed at 40 mg/kg and were seen after desmethylimipramine (50 mg/kg), mianserin (30 mg/kg), amitriptyline (20 mg/kg), imipramine (40 mg/kg), maprotiline (40 mg/kg), and zimelidine (50 mg/kg). Ranking the tested antidepressants in decreasing order in accordance with their relative (pro)convulsive properties gives: amitriptyline greater than mianserin much greater than imipramine greater than desmethylimipramine greater than viloxazine much greater than maprotiline much greater than zimelidine greater than clovoxamine greater than nomifensine = fluvoxamine.
mesh_terms: D000639:Amitriptyline / Q000009:adverse effects; D000818:Animals; D000928:Antidepressive Agents / Q000009:adverse effects*; D003891:Desipramine / Q000009:adverse effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced; D016666:Fluvoxamine; D007099:Imipramine / Q000009:adverse effects; D008297:Male; D008376:Maprotiline / Q000009:adverse effects; D008803:Mianserin / Q000009:adverse effects; D010091:Oximes / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced*; D014745:Viloxazine / Q000009:adverse effects
chemical_list: D000928:Antidepressive Agents; D010091:Oximes; D000639:Amitriptyline; D008803:Mianserin; D008376:Maprotiline; D014745:Viloxazine; C020724:clovoxamine; D016666:Fluvoxamine; D007099:Imipramine; D003891:Desipramine