Dopaminergic and adrenergic influence on gastric acid and pepsin secretion stimulated by food. The role of vagal innervation.
Dopaminergic and adrenergic mechanisms were studied in a dog model which made possible physiological stimulation by food and comparison of vagally innervated and denervated acid and pepsin response at the same time. Five dogs were equipped with two pouches separated from the stomach, and stimulation was done by a standard meal - a mixture of liver, heart and bonemeal , 10 g/kg. The meal was combined with different doses of dopamine 0.1 - 2.0 - 20.0 - 40.0 micrograms/kg/min and with single doses of phentolamine, propranolol and sulpiride separately and combined with dopamine. Acid and pepsin secretion were inhibited in dose-response manner by dopamine in innervated mucosa, but all other effects of the compounds were different in parietal cells and chief cells and in vagally innervated and denervated mucosa.
D000818:Animals; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology*; D018492:Dopamine Antagonists; D004305:Dose-Response Relationship, Drug; D004435:Eating; D005744:Gastric Acid / Q000378:metabolism*; D010434:Pepsin A / Q000378:metabolism*; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D013469:Sulpiride / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000502:physiology*; D014630:Vagus Nerve / Q000502:physiology*
D018492:Dopamine Antagonists; D013469:Sulpiride; D011433:Propranolol; D010434:Pepsin A; D004298:Dopamine; D010646:Phentolamine