Heterogeneous expression of dipeptidyl-amino-peptidase (DAP IV) in T-cell chronic lymphocytic leukemia.
The reactivity for the enzyme dipeptidyl-amino-peptidase IV (DAP IV) has been correlated, in 8 cases of T-cell chronic lymphocytic leukemia (T-CLL), with the cellular phenotype as well as the morphological and clinical behaviour of disease. A highly reproducible correspondence between the 'helper' phenotype (OKT4+/Fc mu-R+) and DAP IV expression was observed in cases with aggressive disease, whereas the cases with OKT8+/Fc mu-R+ phenotype was characterized by a favorable prognosis, LGL (large granular lymphocyte) morphology, and were virtually negative for DAP IV.
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000097:blood*; D010450:Endopeptidases / Q000097:blood*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000201:enzymology* / Q000235:genetics; D008875:Middle Aged; D010641:Phenotype; D013601:T-Lymphocytes / Q000201:enzymology*
D000911:Antibodies, Monoclonal; D010450:Endopeptidases; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases