Experimental pyelonephritis. The effect of T-cell deficiency on the course of hematogenous enterococcal pyelonephritis in the mouse.
The course of experimental hematogenous pyelonephritis due to Streptococcus faecalis was compared in athymic (nu/nu) mice and euthymic (nu/+) littermates. Up to 7 weeks following infection, there were no significant differences in renal microbial populations. At 63 and 107-131 days there was significant escalation of infection in nu/nu mice, while the nu/+ mice were decreasing their infections. There was no increase in gross abscess formation in nu/nu mice, but in late stages significantly more gross scarring occurred in nu/nu as compared with nu/+ mice. Microscopically there was also greater scarring in nu/nu mice late in the disease, except for calyceal lesions. The data suggest that immunologic factors (T cells) are involved in the pathogenesis of chronic pyelonephritis.
D000372:Agglutination Tests; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D002908:Chronic Disease; D013293:Enterococcus faecalis; D005260:Female; D007668:Kidney / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D011704:Pyelonephritis / Q000276:immunology* / Q000382:microbiology / Q000473:pathology; D013290:Streptococcal Infections / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*
D000907:Antibodies, Bacterial