Aminophylline reduces cerebral blood flow velocity in low-birth-weight infants.
Cerebral blood flow decreases substantially in the adult after a single bolus injection of aminophylline. To determine if the cerebral circulation of the low-birth-weight infant behaves in a similar manner, we measured cerebral blood flow velocity (CBFV) in the anterior cerebral arteries of nine infants treated with an intravenous bolus dose of 5 mg/kg of body weight of aminophylline. A reduction in CBFV of 21% and 17% was observed at 60 and 120 minutes following the aminophylline administration. There was a concurrent substantial reduction in PCO2 from 45 +/- 7 to 39 +/- 7 mm Hg before and 120 minutes after the aminophylline administration, respectively. The reduction in CBFV may be the result of a reduction in PCO2 resulting from aminophylline treatment.
D000628:Aminophylline / Q000009:adverse effects*; D001783:Blood Flow Velocity; D002245:Carbon Dioxide / Q000097:blood; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007275:Injections, Intravenous; D010313:Partial Pressure
D002245:Carbon Dioxide; D000628:Aminophylline