Is gamma-camera imaging of platelet deposition useful to assess the effectiveness of prostacyclin treatment?
Platelet labeling with 111-In-oxinesulfate allows visualization of platelet deposition in the vascular bed. Scintigraphic studies were performed in 6 patients with "active" (PUR greater than 1.20) and 8 patients with "inactive" (PUR less than 1.20) atherosclerotic lesions of the femoral artery. Platelet deposition was also studied in 11 patients with implanted prosthetic vascular grafts and in 21 patients with an abnormal aneurysm of the aorta. Infusing 5 ng/kg/min PGI2 during 6 hours for 5 days into patients with "active"-atherosclerosis and aneurysms of the aorta resulted in a significant decrease of platelet deposition even after having stopped the infusion. There was no influence of PGI2 on PUR in patients with "inactive" lesions. The group of patients with implanted prosthetic grafts demonstrated also a significant decrease of PUR values during the PGI2-infusion, but reached baseline values soon after stopping the infusion. When platelet deposition is increased gamma-camera imaging provides valuable date on the influence of any kind of therapy on the in-vivo platelet function.
D001012:Aorta, Abdominal / Q000000981:diagnostic imaging; D001014:Aortic Aneurysm / Q000000981:diagnostic imaging* / Q000188:drug therapy; D001161:Arteriosclerosis / Q000000981:diagnostic imaging* / Q000188:drug therapy; D001792:Blood Platelets / Q000000981:diagnostic imaging*; D011464:Epoprostenol / Q000627:therapeutic use*; D006801:Humans; D007204:Indium; D009942:Organometallic Compounds; D015125:Oxyquinoline / Q000031:analogs & derivatives; D011868:Radioisotopes; D011877:Radionuclide Imaging
D009942:Organometallic Compounds; D011868:Radioisotopes; D007204:Indium; C032950:indium oxine; D015125:Oxyquinoline; D011464:Epoprostenol