[Effect of local moderate hyperthermia in combination with N-nitroso-1,3-bis-(2-chloroethyl)urea (BCNU) and 5-fluoro-(tetrahydro-2-furyl)uracil (ftorafur) on induced autochthonous colonic cancers in the rat. 3: Polychemotherapy in combination with hyperthermia].
The use of hyperthermia for the treatment of tumors has been tested in vitro and in vivo experiments as well as clinically for a long time. Combination of hyperthermia with chemotherapy was reported to result in overadditive cytostatic effects. In a clinically adapted, controlled animal experiment, local moderate hyperthermia (43.5 degrees C, 3 X 60 min) alone and in combination with polychemotherapy (BCNU) and Ftorafur) was used for the treatment of AMMN-(N-nitrosoacetoxymethyl-methylamine) induced autochthonous colonic carcinomas in Sprague-Dawley rats. Diagnosis and follow-up inspections were carried out endoscopically. The applied therapies did not result in prolonged survival times, nor was an additive effect seen after combined hyperthermia and chemotherapy in this "hard", i.e. relatively chemotherapy-resistent, tumor model.
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002273:Carcinogens; D002330:Carmustine / Q000008:administration & dosage; D003106:Colon / Q000473:pathology; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000188:drug therapy / Q000473:pathology; D003131:Combined Modality Therapy; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives* / Q000633:toxicity; D006979:Hyperthermia, Induced / Q000379:methods*; D008297:Male; D011379:Prognosis; D051381:Rats; D011919:Rats, Inbred Strains; D005641:Tegafur / Q000008:administration & dosage
D002273:Carcinogens; D005641:Tegafur; C014659:methyl(acetoxymethyl)nitrosamine; D004128:Dimethylnitrosamine; D002330:Carmustine
Wirkung der lokalen moderaten Hyperthermie in Kombination mit N-Nitroso-1,3-bis-(2-chlorethyl)-harnstoff (BCNU) und 5-Fluor-(tetrahydro-2-furyl)-uracil (Ftorafur) auf induzierte autochthone Coloncarcinome der Ratt. 3. Mitteilung: Polychemotherapie in Kombination mit Hyperthermie.