Hemangioblastoma of the central nervous system: nature of the stromal cells as studied by the immunoperoxidase technique.
Ten hemangioblastomas of the central nervous system were examined by an immunoperoxidase technique for glial fibrillary acidic protein (GFAP), S-100 protein, and Factor VIII-related antigen to determine the origin of the stromal cells. In seven cases scattered stromal cells were positive for GFAP, and eight cases showed variable numbers of S-100 protein-positive cells. These positive cells were present throughout the tumors. S-100 protein-positive stromal cells corresponded to GFAP-positive cells, but the former were more numerous than the latter. Staining for Factor VIII-related antigen was negative in stromal cells, except in endothelial cells lining capillaries. It was suggested that stromal cells of capillary hemangioblastomas are composed by heterogeneous cell populations.
D000328:Adult; D000941:Antigens / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D002528:Cerebellar Neoplasms / Q000473:pathology; D002551:Cerebral Ventricle Neoplasms / Q000473:pathology; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D005260:Female; D005904:Glial Fibrillary Acidic Protein; D006394:Hemangiosarcoma / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007381:Intermediate Filament Proteins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis; D009423:Nervous System Neoplasms / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis; D014841:von Willebrand Factor
D000941:Antigens; D000951:Antigens, Neoplasm; D005904:Glial Fibrillary Acidic Protein; D007381:Intermediate Filament Proteins; D009363:Neoplasm Proteins; D009418:S100 Proteins; D014841:von Willebrand Factor; D005169:Factor VIII