Megakaryoblastic transformation of chronic myelogenous leukaemia in a child.
A child with megakaryoblastic transformation of Ph1-positive chronic myelogenous leukaemia, complicated by myelofibrosis, is reported. The blastic cells were negative for myeloperoxidase by ultrastructural cytochemistry. They had Factor-VIII antigen and platelet glycoprotein but were negative for platelet peroxidase activity. This discrepancy seemed to be due to neoplastic origin of blastic cells.
D000941:Antigens / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D002648:Child; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood*; D008297:Male; D008533:Megakaryocytes / Q000473:pathology*; D008854:Microscopy, Electron; D010544:Peroxidases / Q000097:blood; D014841:von Willebrand Factor
D000941:Antigens; D014841:von Willebrand Factor; D005169:Factor VIII; D010544:Peroxidases