The effect of chemical and surgical sympathectomy on gastric secretion and innervation.
The purpose of this project was to evaluate the effects of chemical and surgical sympathectomy on gastric acid secretion (GAS) and mucosal innervation in the dog. Chemical sympathectomy was achieved with 6-OHDA and surgical sympathectomy was performed by excising the celiac and superior mesenteric ganglia. Gastric biopsies for fluorescence microscopy were taken before and after sympathectomy, as was pentagastrin (PPG) stimulated GAS. Each sympathectomy increased GAS in response to submaximal doses of PPG while simultaneously destroying adrenergic nerve terminals in the gastric mucosa. 6-OHDA caused a complete degeneration of nerve terminals at one week, but regeneration was complete by 9 weeks. The data support the concept that the sympathetic innervation of the stomach is an inhibitor of GAS.
D000818:Animals; D004285:Dogs; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000294:innervation*; D006892:Hydroxydopamines; D008856:Microscopy, Fluorescence; D016627:Oxidopamine; D010418:Pentagastrin / Q000494:pharmacology; D013268:Stimulation, Chemical; D013562:Sympathectomy; D013563:Sympathectomy, Chemical
D006892:Hydroxydopamines; D016627:Oxidopamine; D010418:Pentagastrin