[Clinical studies on preoperative abdominal arterial infusion of anticancer agents].
Operable patients with gastrointestinal cancer were injected once with MMC 0.4 mg/kg, ADM 0.8 mg/kg or KW 2083 1 mg/kg through the abdominal artery 7 to 15 days before operation. Biopsy was made on liver tissues during operation, and changes of serum biochemical test values were observed before and after operation. In 7 cases of MMC 20 mg arterial infusion, 7 cases of ADM 40 mg and 6 cases of KW 2083 50 mg liver biopsy showed fibrosis around the central vein. Eosin bodies, neutrophils or necrotic lesions were observed in some other cases. Serum biochemical test values were transiently affected with anesthesia, but these changes will have no unfavorable influence on the results of operation and following treatment.
D000005:Abdomen / Q000098:blood supply; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D004317:Doxorubicin / Q000008:administration & dosage*; D006801:Humans; D007261:Infusions, Intra-Arterial; D008099:Liver / Q000473:pathology; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage*; D011300:Preoperative Care; D013274:Stomach Neoplasms / Q000201:enzymology / Q000473:pathology*
D008937:Mitomycins; D016685:Mitomycin; D004317:Doxorubicin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase