Suppression of T-cell responses to histocompatibility antigens by BCG pre-treatment.
The injection of 3 mg BCG into C57Bl/6 mice was followed 14 days later by a decrease in reactivity of spleen cells when engaged in mixed-lymphocyte reactions or in graft-versus-host reactions. In vitro, the lack of reactivity was due to an active suppression exerted mainly by the adherent population. In vivo, it was not possible to demonstrate active suppression.
D000818:Animals; D004247:DNA / Q000096:biosynthesis; D006087:Graft vs Host Reaction; D006649:Histocompatibility Antigens / Q000276:immunology*; D007165:Immunosuppression Therapy; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008810:Mice, Inbred C57BL; D009163:Mycobacterium bovis / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D006649:Histocompatibility Antigens; D004247:DNA