Initiation and promotion in experimental oral carcinogenesis.
A subthreshold dose of 0.1% DMBA in oil applied to hamster buccal pouch three times a week for 10 weeks did not result in the development of carcinoma in up to 25 weeks from the start of the experiment. However, if the subthreshold dose of DMBA was followed by 6 weeks of no treatment and six weeks of 40% benzoyl peroxide treatment, carcinomas developed rapidly. Both benzoyl peroxide and its acetone solvent are noncarcinogenic. An experiment carried out on sixty-six young adult male and female Syrian hamsters demonstrated these results, using appropriate controls.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000008:administration & dosage / Q000009:adverse effects*; D000096:Acetone / Q000008:administration & dosage / Q000009:adverse effects*; D000818:Animals; D001585:Benzoyl Peroxide / Q000008:administration & dosage / Q000009:adverse effects*; D006224:Cricetinae; D004347:Drug Interactions; D005260:Female; D008297:Male; D008647:Mesocricetus; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology; D009062:Mouth Neoplasms / Q000139:chemically induced* / Q000473:pathology; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D010545:Peroxides / Q000009:adverse effects*
D010545:Peroxides; D000096:Acetone; D015127:9,10-Dimethyl-1,2-benzanthracene; D001585:Benzoyl Peroxide