title: The human apolipoprotein A-II gene is located on chromosome 1.
abstract: Apolipoprotein (apo) A-II is a major constituent of high density lipoproteins (HDL). The gene for apoA-II has been localized to the p21----qter region of chromosome 1 in man by Southern blot hybridization analysis of DNA from human-mouse cell hybrids using a cloned human apoA-II cDNA probe. The regional assignment was established using two hybrids carrying a reciprocal translocation involving chromosomes 1 and 2. Comparison with previously established gene loci on chromosomes 1 suggests that apoA-II may reside in a conserved linkage group with renin and peptidase C. On the other hand, apoA-II is not linked to the apoA-I gene, which has been localized previously to chromosome 11.
mesh_terms: D000818:Animals; D016633:Apolipoprotein A-II; D001053:Apolipoproteins / Q000235:genetics*; D002874:Chromosome Mapping; D002900:Chromosomes, Human, 1-3; D003001:Cloning, Molecular; D005796:Genes; D006801:Humans; D006822:Hybrid Cells / Q000502:physiology; D007739:L Cells / Q000201:enzymology; D008075:Lipoproteins, HDL / Q000235:genetics*; D051379:Mice; D009693:Nucleic Acid Hybridization; D013937:Thymidine Kinase / Q000235:genetics
chemical_list: D016633:Apolipoprotein A-II; D001053:Apolipoproteins; D008075:Lipoproteins, HDL; D013937:Thymidine Kinase