title: Properties of bovine interferons.
abstract: This study was done in an attempt to elucidate some of the properties of bovine IFNs. Maximum levels of both fibroblast and leukocyte IFNs occurred prior to 24 h whereas maximum levels of immune IFN were not reached until after 72 h. The latter species of IFN was unstable at either pH 2 or 56 degrees C whereas both the fibroblast and leukocyte IFNs were more stable under these conditions. Studies of cross-species protection between fibroblast and leukocyte IFNs indicate that the former was more protective for other species than the latter.
mesh_terms: D000818:Animals; D002417:Cattle; D002460:Cell Line; D003208:Concanavalin A / Q000494:pharmacology; D004355:Drug Stability; D004622:Embryo, Mammalian; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D007370:Interferon Type I / Q000096:biosynthesis*; D007371:Interferon-gamma / Q000096:biosynthesis*; D007668:Kidney; D007700:Kinetics; D007962:Leukocytes / Q000378:metabolism; D009522:Newcastle disease virus / Q000502:physiology; D010835:Phytohemagglutinins / Q000494:pharmacology; D014132:Trachea; D014420:Turbinates
chemical_list: D007370:Interferon Type I; D010835:Phytohemagglutinins; D003208:Concanavalin A; D007371:Interferon-gamma