[Antitumor effect of FU-O-G, new antitumor agent, following long term administration].
FU-O-G, the O-glucuronide methylester of 5-fluorouracil (5-FU), is a compound with a unique chemical structure. It is an antitumor agent of the prodrug type which exerts its activity by enzymatically liberating 5-FU in tumor tissues. It has been reported that the antitumor activity of this compound is superior to those of 5-FU and Tegafur (FT-207) in the treatment of various transplantable tumors. In this study, long-term administration of FU-O-G to mice bearing relatively slow-growing tumors such as Lewis lung carcinoma, mammary tumor FM3 A and hepatoma MH-134 was carried out. Consequently, FU-O-G was shown to be remarkably effective against those tumors, whereas 5-FU and FT-207 were hardly effective. Long-term daily administration was shown to be more effective than intermittent dosage in the treatment of Lewis lung carcinoma. In combination therapies of FU-O-G with other antitumor drugs, FU-O-G exhibited a synergistic effect against Lewis lung carcinoma when combined with Carboquone (CQ) or Nimustine hydrochloride (ACNU).
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002225:Carbazilquinone / Q000008:administration & dosage; D004334:Drug Administration Schedule; D004357:Drug Synergism; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000031:analogs & derivatives; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000401:mortality; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000401:mortality; D051379:Mice; D009368:Neoplasm Transplantation; D015376:Nimustine; D009607:Nitrosourea Compounds / Q000008:administration & dosage; D011741:Pyrimidine Nucleosides / Q000008:administration & dosage / Q000627:therapeutic use*; D005641:Tegafur / Q000008:administration & dosage
D000970:Antineoplastic Agents; D009607:Nitrosourea Compounds; D011741:Pyrimidine Nucleosides; D015376:Nimustine; D005641:Tegafur; D002225:Carbazilquinone; C018604:methyl 1-(5-fluoro-1H-2-oxopyrimidin-4-yl)-beta-D- glucopyranuronate; D005472:Fluorouracil