Basal lamina formation at the site of spinal cord transection.
The pia-glial basal lamina (BL) at the site of spinal cord injury could be an important physical impediment to central nervous system regeneration. We used an epithelial BL-specific immunohistochemical stain to determine the location of the pia-glial BL after spinal cord transection. Small segments of BL were found at the margin of the lesion 5 days after transection. After 10 days, longer and more numerous segments were seen. At 20 days, the entire transected end of the spinal cord was capped by a layer of BL.
D000818:Animals; D003094:Collagen / Q000378:metabolism; D003238:Connective Tissue / Q000473:pathology; D005260:Female; D006023:Glycoproteins / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism; D008854:Microscopy, Electron; D009416:Nerve Regeneration; D009457:Neuroglia / Q000648:ultrastructure; D010841:Pia Mater / Q000473:pathology*; D051381:Rats; D013119:Spinal Cord Injuries / Q000473:pathology*
D006023:Glycoproteins; D006025:Glycosaminoglycans; D003094:Collagen