The removal of hepatitis B virus from factor VIII concentrates by fractionation on ethylene maleic anhydride polyelectrolyte.
Chromatography with a solid-phase polyelectrolyte based on ethylene maleic anhydride polyelectrolyte (EMA PE) has been shown to remove a large proportion of hepatitis B surface antigen (HBsAg), including hepatitis B virus (HBV) particles, from contaminated cryoprecipitate. This process may reduce the risk of transmission of HBV infection when factor VIII concentrates are administered.
D001769:Blood / Q000382:microbiology*; D001803:Blood Transfusion; D002845:Chromatography; D004279:DNA, Viral / Q000032:analysis; D005169:Factor VIII / Q000302:isolation & purification*; D006509:Hepatitis B / Q000635:transmission; D006514:Hepatitis B Surface Antigens / Q000302:isolation & purification; D006515:Hepatitis B virus / Q000302:isolation & purification*; D006801:Humans; D011108:Polymers
D004279:DNA, Viral; D006514:Hepatitis B Surface Antigens; D011108:Polymers; C043483:ethylene maleic anhydride polyelectrolyte; D005169:Factor VIII