Influence of dietary copper on the survival of Drosophila.
The life span of Drosophila melanogaster was reduced when copper compounds were fed at concentrations of 1 X 10(-3) M or greater. Feeding lower concentrations of copper compounds failed to significantly change life span. A combination of copper gluconate and gluconic acid increased the adult life span by 21.6%. We conclude that only an extraordinarily high dietary intake of copper would accelerate senescence. Dietary gluconic acid retarded the normal age-related accumulation of copper in adult flies.
D000818:Animals; D003300:Copper / Q000494:pharmacology* / Q000633:toxicity; D004032:Diet; D004331:Drosophila melanogaster / Q000502:physiology*; D005942:Gluconates / Q000494:pharmacology; D007773:Lactates / Q000494:pharmacology; D019344:Lactic Acid; D008136:Longevity / Q000187:drug effects*; D008297:Male
D005942:Gluconates; D007773:Lactates; D019344:Lactic Acid; D003300:Copper; C030691:gluconic acid