title: Long-lasting single-dose tolerance to neurologic deficits induced by diazepam.
abstract: Development of single-dose tolerance to diazepam-induced neurologic deficits was assessed in mice by means of a rotarod test. Diazepam suspended in corn oil was administered orally in doses 5-20 mg/kg. Tolerance was found following a second administration of diazepam 24 h after a first dose. It decayed gradually over 4-5 weeks. Hence tolerance persists considerably longer than measurable amounts of diazepam or its metabolites are likely to be present in mice.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001259:Ataxia / Q000139:chemically induced; D003975:Diazepam / Q000494:pharmacology*; D004361:Drug Tolerance; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced*; D051381:Rats
chemical_list: D003975:Diazepam