Centronuclear myopathy: extraocular- and limb-muscle findings in an adult.
Myotube-like structures were seen in extraocular and limb muscles in an adult with centronuclear myopathy. The limb-muscle fibers were very small and were of a uniform histochemical type. Extrajunctional acetylcholine receptors were not seen with immunoperoxidase stains, and ultrastructurally normal neuromuscular junctions were seen in the extraocular-muscle samples. Further studies on developing muscle are needed to identify possible mechanisms of arrest of muscle maturation.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000328:Adult; D002467:Cell Nucleus / Q000648:ultrastructure; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008854:Microscopy, Electron; D009132:Muscles / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D009135:Muscular Diseases / Q000378:metabolism / Q000473:pathology*; D009246:NADH Tetrazolium Reductase / Q000378:metabolism; D009469:Neuromuscular Junction / Q000648:ultrastructure; D009801:Oculomotor Muscles / Q000473:pathology / Q000648:ultrastructure; D011950:Receptors, Cholinergic / Q000378:metabolism
D011950:Receptors, Cholinergic; D009246:NADH Tetrazolium Reductase; D000251:Adenosine Triphosphatases