Nootropic drugs reduce immobility in behavioural despair test in mice.
The effect of different nootropic drugs (piracetam, pyritinol, meclofenoxate, methylglucamine orotate, dihydroergotoxine, nicergoline, vinpocetine) on the duration of immobility in the behavioural despair test in mice was studied. All tested nootropics exhibited a dose-related reduction in immobility. In connection with the discussed role of monoaminergic processes in the state of immobility our data support the possible participation of central monoaminergic systems in the mechanisms of action of nootropic drugs.
D000818:Animals; D004088:Dihydroergotoxine / Q000494:pharmacology; D008297:Male; D002504:Meclofenoxate / Q000494:pharmacology; D008536:Meglumine / Q000031:analogs & derivatives / Q000494:pharmacology; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009530:Nicergoline / Q000494:pharmacology; D009963:Orotic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011746:Pyrithioxin / Q000494:pharmacology; D014748:Vinca Alkaloids / Q000494:pharmacology
D011619:Psychotropic Drugs; D014748:Vinca Alkaloids; D004088:Dihydroergotoxine; C013983:vinpocetine; C022100:methylglucamine orotate; D009963:Orotic Acid; D008536:Meglumine; D011746:Pyrithioxin; D002504:Meclofenoxate; D009530:Nicergoline; D010889:Piracetam