[Effect of aminophylline on pulmonary hypertension].
The following study was undertaken as a contribution to a therapeutic programme of pulmonary hypertension. The existence of a functional vascular component in patients suffering from silicosis complicated by chronic latent or manifest pulmonary hypertension has to be assumed. In these cases a therapeutic influence of aminophylline could be observed. The influence of repeated exercise was discerned by means of control group. Furthermore the importance of a rapid analysis of drug serum concentration during investigation by means of high pressure liquid chromatography could be demonstrated.
D000403:Airway Resistance / Q000187:drug effects; D000628:Aminophylline / Q000627:therapeutic use*; D002245:Carbon Dioxide / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy*; D008176:Lung Volume Measurements; D008297:Male; D010100:Oxygen / Q000097:blood; D005082:Physical Exertion; D011652:Pulmonary Circulation / Q000187:drug effects; D012829:Silicosis / Q000150:complications; D014655:Vascular Resistance / Q000187:drug effects
D002245:Carbon Dioxide; D000628:Aminophylline; D010100:Oxygen
Die Wirkung von Aminophyllin auf die pulmonale Hypertonie.