N-methyl-N-formylhydrazine: a toxic and mutagenic inhibitor of the intestinal diamine oxidase.
N-methyl-N-formylhydrazine is the first active intermediate of the poison gyromitrin of the mushroom: false morel. This compound is a non-competitive inhibitor of human intestinal diamine oxidase (ID50 = 1.6 X 10(-5) mol/l). This concentration corresponds to less than 5 g of wet weight of mushroom/l. The diamine oxidases from 5 other sources are inhibited in a similar manner. Semicarbazide and aminoguanidine are 10-respectively 1000-fold more potent inhibitors of the human intestinal diamine oxidase. An involvement of the diamine oxidase inhibitory property of N-methyl-N-formylhydrazine in toxic and mutagenic effects of the substance is considered.
D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors*; D000818:Animals; D006801:Humans; D007413:Intestinal Mucosa / Q000187:drug effects; D007422:Intestines / Q000201:enzymology*; D008763:Methylhydrazines / Q000633:toxicity*; D009002:Monomethylhydrazine / Q000031:analogs & derivatives / Q000633:toxicity*; D009153:Mutagens; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013552:Swine
D008763:Methylhydrazines; D009153:Mutagens; C016577:N-methyl-N-formylhydrazine; D006631:Amine Oxidase (Copper-Containing); D009002:Monomethylhydrazine