title: Antitumor-promoting activity of glycyrrhetic acid in mouse skin tumor formation induced by 7,12-dimethylbenz[a]anthracene plus teleocidin.
abstract: Glycyrrhetic acid inhibited the action of tumor promoter in vitro and in vivo. Glycyrrhetic acid inhibited the increased phospholipid metabolism of cultured cells induced by tumor promoters, 12-O-tetradecanoylphorbol-13-acetate or teleocidin, and it markedly suppressed the promoting effect of teleocidin on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene.
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002273:Carcinogens; D006034:Glycyrrhetinic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D008235:Lyngbya Toxins / Q000633:toxicity*; D051379:Mice; D008813:Mice, Inbred ICR; D010743:Phospholipids / Q000378:metabolism; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000517:prevention & control
chemical_list: D002273:Carcinogens; D008235:Lyngbya Toxins; D010743:Phospholipids; C022176:teleocidins; D015127:9,10-Dimethyl-1,2-benzanthracene; D006034:Glycyrrhetinic Acid