Supersensitivity to the respiratory stimulatory effect of TRH in 5,7-dihydroxytryptamine-treated rats.
Rats treated neonatally with pargyline and 5,7-dihydroxytryptamine (5,7-DHT) have an elevated paCO2 and reduced minute ventilation when given 0.7% halothane in oxygen as adults. Serotonin content in the spinal cord of 5,7-DHT treated rats was undetectable and TRH content was reduced by 35%. The 5,7-DHT treated rats were supersensitive to the increase in minute ventilation and CO2 sensitivity produced by intraventricular TRH. It is possible that the supersensitivity to exogenous TRH after neonatal 5,7-DHT treatment may be secondary to decreased availability of TRH in the CNS.
D015116:5,7-Dihydroxytryptamine / Q000633:toxicity*; D000818:Animals; D001933:Brain Stem / Q000187:drug effects*; D002245:Carbon Dioxide / Q000097:blood; D004102:Dihydroxytryptamines / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D009434:Neural Pathways / Q000187:drug effects; D010100:Oxygen / Q000097:blood; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism; D013116:Spinal Cord / Q000187:drug effects; D013973:Thyrotropin-Releasing Hormone / Q000378:metabolism / Q000494:pharmacology*
D004102:Dihydroxytryptamines; D002245:Carbon Dioxide; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D013973:Thyrotropin-Releasing Hormone; D010293:Pargyline; D010100:Oxygen