[Prognostic efficacy of a histologic-cytochemical malignancy grading of squamous cell carcinoma in the head-neck region].
146 squamous cell carcinomas of the larynx and pharynx were subjected to a histopathological grading of malignancy ranging from grade 1 up to grade 3. 3-years-survival-rates in G 1 carcinomas were 85%, in G 2 72% and in G 3 15%. Various enzyme histochemical reactions were examined by means of the same test material for the worth for the indication of the cure-rate. A high survival-rate was found for low enzyme activities in the G6PDH- and in LDH-reaction. Strong activities indicated a low survival-rate. The histological grading common with histochemical grading is of prognostic significance. It should be used within a multi-step-check aimed at a more detailed tumor diagnosis before the start of therapy.
D002294:Carcinoma, Squamous Cell / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007822:Laryngeal Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D009245:NADH Dehydrogenase / Q000378:metabolism; D010610:Pharyngeal Neoplasms / Q000201:enzymology* / Q000401:mortality / Q000473:pathology; D011379:Prognosis; D013385:Succinate Dehydrogenase / Q000378:metabolism
D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D009245:NADH Dehydrogenase
Prognostische Wirksamkeit einer histologisch-zytochemischen Malignitätsgraduierung beim Plattenepithelkarzinom des Kopf-Hals-Bereiches.