Clindamycin for tetracycline-resistant acne.
Tetracycline, because of its effectiveness, safety, and economy, remains the treatment of choice for chronic maintenance of uncomplicated acne. However, a certain percentage of patients with very difficult acne will not respond satisfactorily to tetracycline. The study presented herein described forty-two patients with nodulocystic acne who did not show imporvement on adequate trials of tetracycline and were switched to low-dose clindamycin. A majority of these patients then showed significant improvement with nine showing essential clearing of the condition. Two patients experienced diarrhea, but recovered immediately after the clindamycin was discontinued.
D000152:Acne Vulgaris / Q000188:drug therapy*; D000293:Adolescent; D000328:Adult; D002981:Clindamycin / Q000009:adverse effects / Q000627:therapeutic use*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D008297:Male; D013752:Tetracycline / Q000627:therapeutic use
D002981:Clindamycin; D013752:Tetracycline