[Treatment of severe febrile neutropenia (author's transl)].
Random allocation of 22 patients with benign and malignant diseases with neutrophil counts of up to 1 X 10(9)/l blood and probably infection-caused fever of more than 38 degrees C to intravenous treatment with one of the following antibiotic combinations was performed: carbenicillin (6 g/m(2) . 6 h) plus sisomicin (45 g/m2 . 6 h) or mezlocillin (3 g/m2 . 6 h) plus sisomicin (45 g/m2 . 6 h). Both combinations were tolerated equally well. Patients became afebrile in 16 out of 23 treatment periods. Seven out of 11 patients responded to carbenicillin - sisomicin, and 9 out of 12 to mezlocillin - sisomicin. Mezlocillin thus leads to equal success of treatment in febrile neutropenia as the double dose of carbenicillin when both antibiotics are combined with the same aminoglycoside.
D000380:Agranulocytosis / Q000188:drug therapy*; D002228:Carbenicillin / Q000008:administration & dosage / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005334:Fever / Q000188:drug therapy; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D008802:Mezlocillin; D009503:Neutropenia / Q000188:drug therapy* / Q000209:etiology; D010406:Penicillins / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation; D012853:Sisomicin / Q000008:administration & dosage / Q000627:therapeutic use*
D005839:Gentamicins; D010406:Penicillins; D002228:Carbenicillin; D008802:Mezlocillin; D012853:Sisomicin
Zur Behandlung der schweren febrilen Neutropenie.