Dimethyl methyl phosphonate induction of dominant lethal mutations in male mice.
The reproductive toxicity of dimethyl methyl phosphonate (DMMP) was studied in the male B6C3F1 mouse. Male mice were treated with 0, 250, 500, 1000, and 2000 mg/kg DMMP by gavage 5 days per week for 13 weeks. After 4, 8 and 12 weeks of treatment the male mice were mated to untreated CD-1 female mice. At the two highest doses (1000 and 2000 mg/kg) the chemical caused a dominant lethal effect (early resorptions). Groups of male mice (at 1000 and 2000 mg/kg), mated after a 15-week recovery period without chemical dosing, had a resorption rate comparable to the control group. After 13 weeks of dosing, the male mice showed no histopathologic changes of the reproductive organs, no abnormalities in sperm concentration or sperm morphology, no evidence for hormone imbalance, no signs of general toxicity, and no effects on the fertilization rate. The male B6C3F1 mouse was less responsive than the male Fischer 344/N rat to the reproductive toxic effects of DMMP.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002802:Cholinesterases / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005640:Follicle Stimulating Hormone / Q000097:blood; D005804:Genes, Lethal / Q000187:drug effects*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D009929:Organ Size / Q000187:drug effects; D009943:Organophosphorus Compounds / Q000633:toxicity*; D013076:Sperm Count
D009153:Mutagens; D009943:Organophosphorus Compounds; C031116:dimethyl methylphosphonate; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002802:Cholinesterases