99mTc-hydroxymethane diphosphonate: a new bone imaging agent with a low tin content.
A prospective double-blind comparison of 99mTc-hydroxymethane diphosphonate (HMDP) and 99mTc-methylene diphosphonate (MDP) as bone-seeking agents was performed with 102 patients. Densitometry showed that both cancellous/compact bone and cancellous bone/soft-tissue ratios were greater with HMDP (p less than 0.05); compact bone/soft-tissue and bone lesion/normal bone ratios were the same with both agents. Bone delineation, soft-tissue uptake, and overall image quality were the same with both agents. The HMDP formulation contained 78% fewer stannous ions and had a longer useful life after technetium labeling than MDP.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000000981:diagnostic imaging; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D004164:Diphosphonates / Q000032:analysis; D004311:Double-Blind Method; D006801:Humans; D008875:Middle Aged; D011877:Radionuclide Imaging; D013667:Technetium / Q000032:analysis; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives; D014001:Tin / Q000032:analysis*
D004164:Diphosphonates; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013667:Technetium; D014001:Tin; D013669:Technetium Tc 99m Medronate