Effect of glycolipids contained in liposomes on the incorporation of beta-galactosidase into specific organs.
A series of glycolipids were examined to find a system capable of targeting liposomes into specific organs of rats. Sulfatide was found to be the best among the components of liposomes examined for delivering the entrapped enzyme, beta-galactosidase from Aspergillus oryzae, into the brain and liver; gangliosides, for the spleen; and sphingomyelin, for the lung. To introduce the enzyme into the liver, galactocerebroside was far better than glucocerebroside. These data suggest that the sugar residues of glycolipids function to target the liposomes into specific organs.
D000818:Animals; D001230:Aspergillus / Q000201:enzymology; D005696:Galactosidases / Q000378:metabolism*; D006017:Glycolipids / Q000032:analysis / Q000494:pharmacology*; D008081:Liposomes / Q000032:analysis / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D001616:beta-Galactosidase / Q000378:metabolism*
D006017:Glycolipids; D008081:Liposomes; D005696:Galactosidases; D001616:beta-Galactosidase