Lyt 1 cells respond to Ia-bearing macrophages in the murine syngeneic mixed lymphocyte reaction.
An autologous mixed lymphocyte reaction has been described in mice and humans in which T cells proliferate following stimulation with syngeneic non-T cells. This report demonstrates that in the murine syngeneic mixed lymphocyte reaction, the responder cell is an Ly1+, Ly23-, Qa-1-T cell. The stimulator is an Ia-bearing macrophage-like cell.
D000818:Animals; D002417:Cattle; D002448:Cell Adhesion; D003602:Cytotoxicity, Immunologic; D005333:Fetus / Q000276:immunology; D000949:Histocompatibility Antigens Class II; D007106:Immune Sera / Q000494:pharmacology; D007519:Isoantigens; D007959:Lymphocyte Culture Test, Mixed; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D010586:Phagocytes; D013601:T-Lymphocytes / Q000276:immunology*
D000949:Histocompatibility Antigens Class II; D007106:Immune Sera; D007519:Isoantigens