Effects of trifluoperazine on smooth muscle actomyosin. Short communication.
Trifluoperazine (TFP) inhibits superprecipitation and ATPase activity of smooth muscle actomyosin. This effect appears not to be due to the inhibitory effect of TFP on the Ca++-dependent modulator and the myosin light chain kinase, which are known to be cofactors required for activation of smooth muscle actomyosin.
D000199:Actins; D000205:Actomyosin / Q000378:metabolism*; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000818:Animals; D002118:Calcium / Q000502:physiology; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism*; D010766:Phosphorylation; D011817:Rabbits; D013552:Swine; D014268:Trifluoperazine / Q000494:pharmacology*
D000199:Actins; D014268:Trifluoperazine; D000205:Actomyosin; D000251:Adenosine Triphosphatases; D002118:Calcium