[Changes in the intracellular localization of pepsinogen-synthesizing polysomes in the gastric mucosa of rats during N-methyl-N'-nitro-N-nitrosoguanidine-induced carcinogenesis].
A study was made of the distribution of pepsinogen-synthesizing polyribosomes in the rat's stomach mucous membrane, in the process of chemical carcinogenesis induced by N-methyl-N'-nitro-N-nitrozoguanidine. A sharp decrease in the content and proteolytic activity of pepsin is shown in cytosol and membrane-bound polyribosomes of the mucous membrane of the rat stomach due to the inducing substance. The appearance of this enzymatic activity is noted in free polyribosomes isolated from the rat stomach tumours.
D000818:Animals; D005609:Free Radicals; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D010434:Pepsin A / Q000378:metabolism; D010435:Pepsinogens / Q000096:biosynthesis*; D011132:Polyribosomes / Q000187:drug effects* / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D013997:Time Factors
D005609:Free Radicals; D010435:Pepsinogens; D008769:Methylnitronitrosoguanidine; D010434:Pepsin A
Izmenenie vnutrikletochnoĭ lokalizatsii pepsinogenosinteziruiu-shchikh polisom v slizistoĭ obolochke zheludka krys pri kantserogeneze, vyzvannom N-metil-N'-nitro-N-nitrozoguanidinom.