Effects of a benzodiazepine antagonist on the diazepam-induced electrical brain activity modifications.
Brain electrical activity changes induced by Ro 15-1788, an antagonist of central benzodiazepine effects, were investigated in 10 normal subjects. The diazepam-induced sedation, as ascertained by spontaneous EEG, was rapidly reversed after an intravenous injection of 5 mg Ro 15-1788. There appeared to be a good correlation between the EEG and evoked responses modifications; the decrease of the amplitude of the N2 wave may reflect an increase of alertness.
D000328:Adult; D001570:Benzodiazepinones / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D003975:Diazepam / Q000037:antagonists & inhibitors*; D004569:Electroencephalography; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005442:Flumazenil; D006801:Humans
D001570:Benzodiazepinones; D005442:Flumazenil; D003975:Diazepam