Nuclear particles of non-A, non-B type in healthy volunteers and patients with hepatitis B.
In an electron microscopic study, nuclear aggregates of virus-like spherical and tubular particles measuring 20 to 29 nm in diameter were found in 5 of 7 clinically healthy volunteers with normal liver histology, 6 of 10 patients with hepatitis B and 17 of 18 patients with hepatitis non-A, non-B. The incidence of hepatocytes containing nuclear particles was approximately 0.5 to 2% in all three groups. We conclude that these nuclear particles are not specific ultrastructural markers of hepatitis non-A, non-B in man as originally claimed for experimental hepatitis non-A, non-B in chimpanzees.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D002467:Cell Nucleus / Q000648:ultrastructure*; D005260:Female; D005455:Fluorescent Antibody Technique; D006509:Hepatitis B / Q000473:pathology*; D006511:Hepatitis B Antigens / Q000032:analysis; D006512:Hepatitis B Core Antigens / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006526:Hepatitis C / Q000473:pathology*; D035923:Hepatitis delta Antigens; D006525:Hepatitis, Viral, Human / Q000473:pathology*; D006801:Humans; D008099:Liver / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged
D006511:Hepatitis B Antigens; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D035923:Hepatitis delta Antigens