Stability of (2'-5')oligoriboadenylates in various sera.
Avian and mammalian sera were found to contain an enzyme activity degrading 2-5A oligonucleotides. The most extensive degradation of the A2' p5' A was observed in chicken serum. Degradation of this compound is not affected by the presence of cAMP, dsRNA, Mg2+, but is significantly inhibited by EDTA. The enzyme activity described is not inactivated by heating to 56 degrees C for 30 min. The 5-mU3' p5' A has also been degraded in chicken serum.
D000227:Adenine Nucleotides / Q000097:blood*; D000818:Animals; D001717:Birds; D002417:Cattle; D002645:Chickens; D004492:Edetic Acid / Q000494:pharmacology; D005777:Geese; D007700:Kinetics; D009841:Oligonucleotides / Q000097:blood*; D009843:Oligoribonucleotides / Q000097:blood*; D012756:Sheep; D013045:Species Specificity; D013329:Structure-Activity Relationship; D014422:Turkeys
D000227:Adenine Nucleotides; D009841:Oligonucleotides; D009843:Oligoribonucleotides; C023505:2',5'-oligoadenylate; D004492:Edetic Acid