[Investigations concerning the mechanism of contrast damage. The significance lipophilia (author's transl)].
The damaging action on vascular endothelia of meglumin iothalamate and of meglumin ioxitalamate was tested on the rat aorta. Ioxitalamate was significantly better tolerated than iothalamate. The octanol-water-partition coefficient of various contrast media was evaluated by assessing the iodine content of the octanol phase after mixing. The coefficients found were about 100 fold lower than the coefficients computed by Levitan and Rapoport. The significance of the octanol-water-partition coefficient for endothelial injuries caused by contrast media is disputed.
D001808:Blood Vessels / Q000187:drug effects* / Q000473:pathology; D003287:Contrast Media / Q000009:adverse effects*; D004727:Endothelium / Q000187:drug effects / Q000473:pathology; D006801:Humans; D007482:Iothalamate Meglumine / Q000009:adverse effects; D000442:Octanols; D012016:Reference Values; D012995:Solubility
D003287:Contrast Media; D000442:Octanols; D007482:Iothalamate Meglumine
Untersuchungen über den Mechanismus von Kontrastmittelschäden, die Bedeutung der Lipophilie.