Effect of disodium cromoglycate on the action of bronchoactive agents in guinea-pig tracheal strips.
The effect of disodium cromoglycate (DSCG) on the action of various bronchoactive agents was investigated using isolated guinea-pig tracheal strips. DSCG attenuated the acetylcholine-induced contractile responses and shifted the dose-response curve of acetylcholine downward. It also attenuated the histamine-, serotonin-, bradykinin- and PGF2 alpha-induced contractile responses dose-dependently. On the other hand, DSCG potentiated the isoprenaline (isoproterenol)-, epinephrine-, PGE2- and salbutamol-induced relaxation responses, and shifted these dose-response curves downward. Such a shift became dominant by increasing the dose of DSCG. The above results suggest that DSCG might have a direct action on bronchial smooth muscle in addition to the inhibition of the release of chemical mediators from mast cells.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects*; D004205:Cromolyn Sodium / Q000494:pharmacology*; D015237:Dinoprost; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D011460:Prostaglandins F / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects
D011460:Prostaglandins F; D012701:Serotonin; D006632:Histamine; D015237:Dinoprost; D000109:Acetylcholine; D004205:Cromolyn Sodium; D001920:Bradykinin