The promoting effect of amphotericin B on the incorporation of neocarzinostatin into human gastric cancer tissue.
AmB/NCS combination therapy against cancer was evaluated. Six gastric cancer patients were treated in this manner, and 7 gastric cancer patients treated with NCS alone to serve as the control. AmB sirup was administered orally for 4 days before surgical operation. NCS was given intraveously at the onset of gastric surgery. Lesion tissues and healthy tissues were collected from each patient and the NCS titers were measured by bioassay. It was shown in the majority of the gastric cancer cases that the NCS levels in the lesion tissues were substantially higher than in the surrounding normal tissues, whereas in the gastric cancer patients who received NCS alone, no significant differences were found between the tissues.
D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000378:metabolism*; D001681:Biological Assay; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000032:analysis / Q000378:metabolism*; D009353:Zinostatin / Q000032:analysis / Q000378:metabolism*
D000903:Antibiotics, Antineoplastic; D000666:Amphotericin B; D009353:Zinostatin