A comparison between the use of a shadow shield whole body counter and an uncollimated gamma camera ain the assessment of the seven-day retention of SeHCAT.
We have compared the 7-day retention of the radioisotope bile salt analogue SeHCAT (75Se-23-selena-25-homotaurocholate), by whole body counting and by uncollimated gamma camera measurement, in phantoms and in 25 patients with inflammatory bowel disease. The results correlate with a linear correlation coefficient of 0.96. An uncollimated gamma camera can be used to assess bile acid malabsorption when a whole body radioactivity monitor is not available.
D003093:Colitis, Ulcerative / Q000000981:diagnostic imaging* / Q000378:metabolism; D003424:Crohn Disease / Q000000981:diagnostic imaging* / Q000378:metabolism; D006801:Humans; D007082:Ileum / Q000000981:diagnostic imaging* / Q000378:metabolism; D007408:Intestinal Absorption; D008722:Methods; D008961:Models, Structural; D011868:Radioisotopes; D011877:Radionuclide Imaging; D012643:Selenium / Q000378:metabolism; D013656:Taurocholic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D014915:Whole-Body Counting
D011868:Radioisotopes; D013656:Taurocholic Acid; C033638:23-seleno-25-homotaurocholic acid; D012643:Selenium