An improved technique for producing ventricular hypertrophy with a subcoronary valvular aortic stenosis model.
Although techniques for producing aortic valve stenosis proximal to the ostia of the coronary arteries have been described in experimental animals, only moderate left ventricular hypertrophy has been obtained. A technique for plicating the noncoronary sinus of Valsalva in puppies is presented that has enabled us to achieve levels of ventricular hypertrophy not previously reported with methods for subcoronary aortic stenosis.
D000818:Animals; D001020:Aortic Stenosis, Subvalvular; D006332:Cardiomegaly; D002312:Cardiomyopathy, Hypertrophic; D004195:Disease Models, Animal; D004285:Dogs; D008722:Methods; D012850:Sinus of Valsalva