The anxiogenic action of Ro 15-1788 is reversed by chronic, but not by acute, treatment with chlordiazepoxide.
The benzodiazepine receptor antagonist, Ro 15-1788 (10 mg/kg) is anxiogenic in the social interaction test. Acute administration of chlordiazepoxide (5 or 10 mg/kg) did not reverse the anxiogenic effects of Ro 15-1788; however, in animals pretreated with chlordiazepoxide (5 mg/kg) for 5 days prior to testing, there was a reduction in the anxiety produced by Ro 15-1788.
D000818:Animals; D001007:Anxiety / Q000139:chemically induced*; D001570:Benzodiazepinones / Q000037:antagonists & inhibitors*; D002707:Chlordiazepoxide / Q000008:administration & dosage / Q000494:pharmacology*; D005442:Flumazenil; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D012919:Social Behavior / Q000187:drug effects*; D013997:Time Factors
D001570:Benzodiazepinones; D005442:Flumazenil; D002707:Chlordiazepoxide