title: Extended superfamily of short alcohol-polyol-sugar dehydrogenases: structural similarities between glucose and ribitol dehydrogenases.
abstract: The recently determined primary structure of glucose dehydrogenase from Bacillus megaterium was scanned by computerized comparisons for similarities with known polyol and alcohol dehydrogenases. The results revealed a highly significant similarity between this glucose dehydrogenase and ribitol dehydrogenase from Klebsiella aerogenes. Sixty-one positions of the 262 in glucose dehydrogenase are identical between these two proteins (23% identity), fitting into a homology alignment for the complete polypeptide chains. The extent of similarity is equivalent to that between other highly divergent but clearly related dehydrogenases (two zinc-containing alcohol dehydrogenases, 25%; sorbitol and zinc-containing alcohol dehydrogenases, 25%; ribitol and non-zinc-containing alcohol dehydrogenases, 20%), and suggests an ancestral relationship between glucose and ribitol dehydrogenases from different bacteria . The similarities fit into a previously suggested evolutionary scheme comprising short and long alcohol and polyol dehydrogenases, and greatly extend the former group to one composed of non-zinc-containing alcohol-polyol-glucose dehydrogenases.
mesh_terms: D000426:Alcohol Dehydrogenase; D000429:Alcohol Oxidoreductases; D000595:Amino Acid Sequence; D000818:Animals; D001410:Bacillus megaterium / Q000201:enzymology; D002237:Carbohydrate Dehydrogenases; D004331:Drosophila melanogaster / Q000201:enzymology; D042843:Glucose 1-Dehydrogenase; D005948:Glucose Dehydrogenases; D006736:Horses; D007711:Klebsiella pneumoniae / Q000201:enzymology; D007064:L-Iditol 2-Dehydrogenase; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D012756:Sheep; D013401:Sugar Alcohol Dehydrogenases
chemical_list: D000429:Alcohol Oxidoreductases; D002237:Carbohydrate Dehydrogenases; D013401:Sugar Alcohol Dehydrogenases; D005948:Glucose Dehydrogenases; D000426:Alcohol Dehydrogenase; D007064:L-Iditol 2-Dehydrogenase; D042843:Glucose 1-Dehydrogenase; C022529:ribitol 2-dehydrogenase