Reactions of infectious mononucleosis sera with glutaraldehyde-treated human erythrocytes.
Infectious mononucleosis sera gave positive results in enzymoimmunoassay with glutaraldehyde-treated human erythrocytes. This unexpected reaction appeared to be caused by the interaction of Paul-Bunnell (P-B) antibodies with a partial P-B antigen that apparently appears on human red blood cells in a hidden form and becomes exposed by the treatment with glutaraldehyde.
D000447:Aldehydes / Q000494:pharmacology*; D015478:Antigens, Heterophile / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects*; D005976:Glutaral / Q000494:pharmacology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007163:Immunosorbent Techniques; D007244:Infectious Mononucleosis / Q000097:blood*; D008258:Waldenstrom Macroglobulinemia / Q000097:blood
D000447:Aldehydes; D015478:Antigens, Heterophile; D005976:Glutaral