title: Comparison of Intralipid 10% and Intralipid 20% as a source of energy and essential fatty acids--a multicenter study.
abstract: A multicenter clinical study was done which directly compared efficacy and safety of Intralipid 10% and Intralipid 20%. Twenty-nine patients received the 10% concentration, 30 patients received the 20% concentration. Both groups of patients received equivalent amounts of calories, amino acids, dextrose and fat for seven day study periods. Analysis of nitrogen balance data showed that the two preparations were equally effective in maintaining nitrogen balance. Both concentrations of fat emulsion were effective in reversing or correcting the changes of essential fatty acid deficiency. Analysis of clinical laboratory data indicated that both preparations were equally well tolerated by the patients. No adverse effects attributed to the fat emulsions were observed.
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000008:administration & dosage; D001777:Blood Coagulation; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D004573:Electrolytes / Q000097:blood; D002149:Energy Intake; D004906:Erythrocyte Count; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D005227:Fatty Acids / Q000097:blood; D005228:Fatty Acids, Essential / Q000008:administration & dosage*; D005260:Female; D005947:Glucose / Q000008:administration & dosage; D006400:Hematocrit; D006801:Humans; D008055:Lipids / Q000097:blood; D008111:Liver Function Tests; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D009994:Osmolar Concentration; D010289:Parenteral Nutrition, Total
chemical_list: D000596:Amino Acids; D001786:Blood Glucose; D004573:Electrolytes; D005217:Fat Emulsions, Intravenous; D005227:Fatty Acids; D005228:Fatty Acids, Essential; D008055:Lipids; D005947:Glucose; D009584:Nitrogen