title: Effects of trifluoperazine on smooth muscle actomyosin. Short communication.
abstract: Trifluoperazine (TFP) inhibits superprecipitation and ATPase activity of smooth muscle actomyosin. This effect appears not to be due to the inhibitory effect of TFP on the Ca++-dependent modulator and the myosin light chain kinase, which are known to be cofactors required for activation of smooth muscle actomyosin.
mesh_terms: D000199:Actins; D000205:Actomyosin / Q000378:metabolism*; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000818:Animals; D002118:Calcium / Q000502:physiology; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000378:metabolism*; D010766:Phosphorylation; D011817:Rabbits; D013552:Swine; D014268:Trifluoperazine / Q000494:pharmacology*
chemical_list: D000199:Actins; D014268:Trifluoperazine; D000205:Actomyosin; D000251:Adenosine Triphosphatases; D002118:Calcium