title: Turnover rates and synthesis of cardiac structural proteins in normal and hypertrophied heart.
abstract: Turnover rates and synthesis of cardiac structural proteins were studied in normal and hypertrophied rabbit heart. The order of incorporation rates of radioactive lysine in normal heart was: left ventricular greater than right ventricular greater than atrial greater than skeletal myosin B. In left ventricular muscle, the order of relative turnover rates of structural proteins was: native tropomyosin greater than the complex of 10 S-actinin and alpha-actinin greater than myosin heavy chain greater than myosin light chain greater than (soluble protein) greater than actin. After aortic constriction (to three-fourths of its original circumference), the rates of incorporation of radioactive lysine into each structural protein fraction increased, reaching a peak on the 7th day. The values returned to the levels of the normal group after 1 month. It was noted that the increase of incorporation into native tropomyosin was greater than the other structural proteins 7 days after constriction.
mesh_terms: D000185:Actinin / Q000378:metabolism; D000199:Actins / Q000378:metabolism; D000818:Animals; D006332:Cardiomegaly / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D009218:Myosins / Q000378:metabolism; D014176:Protein Biosynthesis; D011506:Proteins / Q000378:metabolism*; D011817:Rabbits; D014335:Tropomyosin / Q000378:metabolism
chemical_list: D000199:Actins; D011506:Proteins; D014335:Tropomyosin; D000185:Actinin; D009218:Myosins; D008239:Lysine