Imipenem antagonism of the in vitro activity of piperacillin against Pseudomonas aeruginosa.
The MICs of imipenem and piperacillin, alone and in combination, against Pseudomonas aeruginosa were determined in a checkerboard titration microdilution assay. A dramatic, one-way antagonism of imipenem for piperacillin was demonstrated in 28 of the 35 strains examined; antagonism was associated with the induction of a beta-lactamase.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D015378:Imipenem; D008826:Microbial Sensitivity Tests; D010878:Piperacillin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013845:Thienamycins / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D013845:Thienamycins; D015378:Imipenem; D010878:Piperacillin