[Effect of somatocrinin 1-40 (hpGRF-40) on human prolactinoma].
Growth Hormone-Releasing 1-40, from a human pancreatic tumor (hpGRF-40), stimulates adenylate cyclase activity of a subcellular preparation enriched in plasma membranes from a human prolactin-secreting pituitary adenoma. hpGRF-40 and VIP have 9 common residues. Nevertheless, the effects on adenylate cyclase are additive, suggesting the existence of specific receptors to hpGRF-40 in human prolactinoma.
D000236:Adenoma / Q000378:metabolism* / Q000648:ultrastructure; D000262:Adenylyl Cyclases / Q000378:metabolism; D000328:Adult; D002462:Cell Membrane / Q000201:enzymology; D005260:Female; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D010446:Peptide Fragments / Q000494:pharmacology*; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000648:ultrastructure; D011388:Prolactin / Q000378:metabolism*
D010446:Peptide Fragments; C036893:somatotropin releasing factor 40; D011388:Prolactin; D013007:Growth Hormone-Releasing Hormone; D000262:Adenylyl Cyclases
Effet de la somatocrinine 1-40 (hpGRF-40) sur le prolactinome humaine.