Isolation, structure, and synthesis of a human seminal plasma peptide with inhibin-like activity.
A basic peptide isolated from pooled human seminal plasma exhibited inhibin-like activity by suppressing pituitary follicle-stimulating hormone secretion in vitro and in vivo. The peptide has been characterized and sequenced, and a 31-amino-acid synthetic replicate showed full biological activity in vitro.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006801:Humans; D007265:Inhibins / Q000302:isolation & purification* / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D051379:Mice; D008970:Molecular Weight; D010455:Peptides / Q000138:chemical synthesis / Q000302:isolation & purification; D010902:Pituitary Gland / Q000378:metabolism; D029584:Prostatic Secretory Proteins; D011506:Proteins / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D012661:Semen / Q000032:analysis*; D029589:Seminal Plasma Proteins
D000596:Amino Acids; D010455:Peptides; D029584:Prostatic Secretory Proteins; D011506:Proteins; D029589:Seminal Plasma Proteins; C043076:beta-microseminoprotein; D007987:Gonadotropin-Releasing Hormone; D007265:Inhibins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone