The effect of corticosteroids, dapsone and gold upon plasminogen activator synthesis and secretion by human epidermal cells cultured with pemphigus antibody.
Human epidermal cells were cultured with pemphigus antibody in the presence of hydrocortisone, methylprednisolone sodium succinate, dapsone and gold. Hydrocortisone and methylprednisolone reduced the production of the enzyme plasminogen activator but dapsone and gold had no effect. These results support the hypothesis that corticosteroids have dual effects on pemphigus through inhibition of plasminogen activator production by epidermal cells and suppression of pemphigus antibody production by B lymphocytes.
D000906:Antibodies / Q000276:immunology*; D002478:Cells, Cultured; D003622:Dapsone / Q000494:pharmacology; D004817:Epidermis / Q000187:drug effects*; D006052:Gold Sodium Thiomalate / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D007231:Infant, Newborn; D008776:Methylprednisolone Hemisuccinate / Q000494:pharmacology; D010392:Pemphigus / Q000276:immunology*; D010960:Plasminogen Activators / Q000096:biosynthesis*; D013997:Time Factors
D000906:Antibodies; D006052:Gold Sodium Thiomalate; D008776:Methylprednisolone Hemisuccinate; D003622:Dapsone; D010960:Plasminogen Activators; D006854:Hydrocortisone