An HLA-linked immune suppression gene in man.
Genetic control of immune response in man was investigated with the system of antigen-specific T cell proliferation in vitro against streptococcal cell wall (SCW) antigen. Family analysis by Morton's maximum likelihood scoring method revealed that the low response to SCW antigen was controlled by a single dominant gene. Furthermore, this gene was shown to be closely linked to HLA (lod score was 3,209 at theta = 0). This is the first description of the HLA-linked immune suppression gene in man. The possible mechanism for this gene action was discussed.
D000328:Adult; D000942:Antigens, Bacterial / Q000276:immunology; D002648:Child; D005799:Genes, Dominant; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008213:Lymphocyte Activation; D010375:Pedigree; D010641:Phenotype; D013291:Streptococcus / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000942:Antigens, Bacterial; D006680:HLA Antigens