Dynamics of regression of right ventricular hypertrophy in rats with hypoxic pulmonary hypertension.
Normobaric hypoxia caused a significant increase in right/left ventricular weight ratio in rats, a reliable indicator of hypertrophy of the right ventricle, already after 1 week of intermittent hypoxic confinement 7 days after termination of a 4-week hypoxic exposure the right/left ventricular weight ratio was significantly lower compared to the values immediately after hypoxic treatment. 8 weeks of sojourning in a normoxic environment were not sufficient to normalize the right ventricular systolic pressure and right/left ventricular weight ratio. It is concluded that changes in the right ventricular mass in rat is a fast reaction to the changes in pressure load.
D000818:Animals; D001794:Blood Pressure; D006332:Cardiomegaly / Q000209:etiology / Q000503:physiopathology*; D004194:Disease; D005260:Female; D000860:Hypoxia / Q000150:complications; D051381:Rats; D012075:Remission, Spontaneous; D013997:Time Factors