The toxicity of tritium: the effects of tritiated amino-acids on preimplanted mouse embryos.
The effects of tritiated amino-acids, arginine, lysine, histidine and aspartic acid on the growth and development of two-cell mouse embryos, cultured in vitro, were investigated. The LD50 for the dibasic amino acids, measured on the third day of growth, ranged from 30 to 130 nCi/ml. This was compared with the DNA precursor, thymidine, for which the LD50 was 80 nCi/ml.
D000596:Amino Acids; D000818:Animals; D001120:Arginine; D001224:Aspartic Acid; D001755:Blastocyst / Q000528:radiation effects*; D005260:Female; D006639:Histidine; D008239:Lysine; D051379:Mice; D013936:Thymidine; D013997:Time Factors; D014316:Tritium
D000596:Amino Acids; D014316:Tritium; D001224:Aspartic Acid; D006639:Histidine; D001120:Arginine; D008239:Lysine; D013936:Thymidine