[Population structure of the forest Nentsi. IV. Immunoglobulin allotypes and the concentration and origin of Gm haplotypes with a null expression of the C gammal gene].
Serum blood samples from 796 of the total 1600 Forest Nentsi, the members of the isolate in the north-western part of Siberia were tested for the G1m (z, a, x, f), G2m (n), G3m (g, b0, b1, b3, b5, s, t) and Km (1) antigens. Significant heterogeneity in local Gm haplotype and Km1 allele frequencies has been found. The frequencies of "deleted" Gm (-; n; b) and Gm (-;..; g) haplotypes were found to be equal 0,020 and 0,004, respectively. When segregation disturbances for the Gm locus were inspected in 102 families, no apparent deviations from Mendelian expectations occurred. Blent, Oriental-Caucasian origin of Forest Nentsi has been confirmed by the presence of "Northern Oriental" Gm (za; b035st) and "Caucasian" Gm (f; b0135) markers showing the frequency of 0.199 and 136, respectively.
D001110:Arctic Regions; D003081:Cold Climate; D005006:Ethnicity; D005260:Female; D005786:Gene Expression Regulation; D005787:Gene Frequency; D005796:Genes; D005828:Genetics, Population; D005838:Genotype; D006238:Haploidy; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007142:Immunoglobulin gamma-Chains / Q000235:genetics*; D008297:Male; D010375:Pedigree; D010641:Phenotype; D012800:Siberia
D007126:Immunoglobulin Allotypes; D007143:Immunoglobulin Heavy Chains; D007142:Immunoglobulin gamma-Chains
Populiatsionnaia struktura lesnykh nentsev. Soobshchenie IV. Allotipy immunoglobulinov, kontsentratsiia i proiskhozhdenie Gm-gaplotipov s nulevoĭ ékspressieĭ C gammal-gena.