The immunosuppressive effect of beta-[1-phenyl-5-bis(beta-chloroethyl)-aminobenzimidazolyl-(2)]-DL-alanine (ZIMET 3164) on cell-mediated immunity in mice.
The potential immunosuppressive drug beta-[1-Phenyl-5-bis(beta-chloroethyl-5-amino-benzimidazolyl-(2)]-DL-alanine (ZIMET 3164) was tested for its effect on cell-mediated immunity. The models "skin grafting" and "contact hypersensitivity" were used. --The results showed a marked prolongation of the mean survival time of the skin grafts and also a high depression of the contact hypersensitivity (delayed hypersensitivity) to picryl chloride. The immunosuppressive efficacy of ZIMET 3164 was higher than that of the reference compound cyclophosphamide.
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D004342:Drug Hypersensitivity / Q000188:drug therapy*; D006085:Graft Survival / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects*; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D010853:Picryl Chloride; D051381:Rats; D016038:Skin Transplantation; D014183:Transplantation, Heterologous
D001562:Benzimidazoles; D009588:Nitrogen Mustard Compounds; C022820:IMET 3146; D010853:Picryl Chloride