[Pharmacokinetics and antibacterial activity of ticarcillin in 11 patients with cystic fibrosis].
We studied the pharmacokinetics of ticarcillin in cystic fibrosis patients. Concentrations of ticarcillin were assayed in serum and sputum samples from 11 children. We found that antibiotic serum concentrations were consistent with those reported in the literature. Ticarcillin half-life was shorter in patients than in controls. No direct correlation was found between concentrations in serum and those in sputum. Among six children with P. aeruginosa infection, ticarcillin levels in sputum were sufficient to eliminate P. aeruginosa in 50% of cases.
D000293:Adolescent; D002648:Child; D003550:Cystic Fibrosis / Q000378:metabolism* / Q000382:microbiology; D006801:Humans; D007700:Kinetics; D010406:Penicillins / Q000378:metabolism*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013183:Sputum / Q000378:metabolism; D013982:Ticarcillin / Q000097:blood / Q000378:metabolism* / Q000494:pharmacology
D010406:Penicillins; D013982:Ticarcillin
Pharmacocinétique et activité antibactérienne de la ticarcilline chez onze malades atteints de mucoviscidose.