6,9-deepoxy-6,9-(phenylimino)-delta 6,8-Prostaglandin I1, (U-60,257) stimulates prostaglandin D2 and inhibits thromboxane B2 release from ionophore challenged human dispersed lung cells.
6,9-deepoxy- 6,9-(phenylimino)-delta 6,8-Prostaglandin I1 (U-60,257), a prostaglandin analogue known to inhibit leukotriene formation in a number of cell systems, potentiates mast cell release of prostaglandin D2 from human dispersed lung cells activated with ionophore A23187. Over the same concentration range of 30-300 microM there was a related inhibition of ionophore-induced generation of thromboxane B2 (r = 0.93, P less than 0.01). As both prostaglandin D2 and thromboxane A2 are potent bronchoconstrictors, these observations may be relevant to the potential of this drug in the treatment of asthma.
D000001:Calcimycin / Q000494:pharmacology; D015237:Dinoprost; D011464:Epoprostenol / Q000494:pharmacology* / Q000031:analogs & derivatives; D006801:Humans; D066298:In Vitro Techniques; D008168:Lung / Q000166:cytology / Q000378:metabolism*; D008407:Mast Cells / Q000378:metabolism; D015230:Prostaglandin D2; D011457:Prostaglandins D / Q000378:metabolism*; D011460:Prostaglandins F / Q000096:biosynthesis; D013929:Thromboxane B2 / Q000037:antagonists & inhibitors*; D013931:Thromboxanes / Q000037:antagonists & inhibitors*
D011457:Prostaglandins D; D011460:Prostaglandins F; D013931:Thromboxanes; D000001:Calcimycin; D013929:Thromboxane B2; D015237:Dinoprost; D011464:Epoprostenol; C035296:piriprost; D015230:Prostaglandin D2