Round cells of the epidermis: clues from studies on neoplastic lymphocytes of cutaneous T cell lymphoma.
Neoplastic cells of cutaneous T cell lymphoma (CTCL) appear to be of monoclonal origin and frequently are nonspecific helpers of normal B cell differentiation. A natural progression from epidermotropic (mycosis fungoides and Sézary syndrome) to nonepidermotropic, more widely disseminated T cell neoplasms generally occurs. Affinity of CTLC cells for the epidermis may result from their having membrane receptors for histocompatibility (Ia) antigens present in skin. Cultured human epidermal cells produce a thymopoietin-like molecule, an indication of a role for skin in T cell differentiation.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000032:analysis; D000951:Antigens, Neoplasm / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D002454:Cell Differentiation; D002455:Cell Division; D002465:Cell Movement; D004817:Epidermis / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology; D007519:Isoantigens / Q000276:immunology; D007801:Langerhans Cells / Q000276:immunology; D008223:Lymphoma / Q000276:immunology / Q000473:pathology*; D051379:Mice; D011817:Rabbits; D012878:Skin Neoplasms / Q000473:pathology*; D013601:T-Lymphocytes / Q000032:analysis / Q000276:immunology / Q000473:pathology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D007136:Immunoglobulins; D007519:Isoantigens