Enhanced Escherichia coli susceptibility to nitrofurantoin by EDTA and multiple aminoglycoside antibiotics resistance mutation.
Subinhibitory concentrations of ethylenediaminetetraacetic acid (EDTA) increased the susceptibility of Escherichia coli K12 multiple aminoglycoside antibiotics and nitrofurantoin-resistant mutants to aminoglycoside antibiotics (20- to 25-fold) and nitrofurantoin (15-fold). The same concentration of EDTA also increased the susceptibility of high-level nitrofurantoin-resistant mutants to nitrofurantoin. Aminoglycoside-resistant mutants with increased susceptibility to nitrofurantoin (2- to 3-fold) were selected with neomycin from E. coli nitrofurantoin-sensitive and resistant mutants. Decreased permeability of nitrofurantoin is inferred as one of the mechanisms of nitrofurantoin resistance.
D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D004492:Edetic Acid / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D009154:Mutation; D009355:Neomycin / Q000494:pharmacology*; D009582:Nitrofurantoin / Q000494:pharmacology*
D009582:Nitrofurantoin; D004492:Edetic Acid; D009355:Neomycin