Effect of intrabiliary administration of Triton X-100 on biliary excretory function in the rat.
Intrabiliary administration of Triton X-100 is of interest in producing effects on biliary tree permeability and canalicular biliary excretory function. Treatment with 0.4% Triton (40 microliter) was shown to increase the biliary excretion of intraportally administered [3H]sucrose. It also decreased recovery of [3H]sucrose given into the biliary tree. Thus, we concluded that Triton treatment increased biliary tree permeability. Using a different set of marker compounds, canalicular transport of bromphenol blue, [14C]morphine glucuronide and [3H]ouabain was found to be decreased. The fact that [3H] taurocholate excretion into bile was not affected whereas that of [3H]ouabain was lends support to the concept that taurocholate and ouabain are not transported by a common pathway.
D000818:Animals; D001646:Bile / Q000187:drug effects* / Q000378:metabolism; D001652:Bile Ducts; D001978:Bromphenol Blue / Q000378:metabolism; D003902:Detergents / Q000494:pharmacology*; D007267:Injections; D007275:Injections, Intravenous; D008297:Male; D008353:Mannitol / Q000378:metabolism; D009020:Morphine / Q000378:metabolism; D017830:Octoxynol; D010042:Ouabain / Q000378:metabolism; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011169:Portal Vein; D051381:Rats; D011919:Rats, Inbred Strains; D013395:Sucrose / Q000378:metabolism; D013501:Surface-Active Agents / Q000494:pharmacology*; D013656:Taurocholic Acid / Q000378:metabolism
D003902:Detergents; D013501:Surface-Active Agents; D001978:Bromphenol Blue; D008353:Mannitol; D011092:Polyethylene Glycols; D013395:Sucrose; D010042:Ouabain; D013656:Taurocholic Acid; D009020:Morphine; D017830:Octoxynol