Effects of the dipyridamol-dihydroergotoxine methane sulphonate associations on pO2 and its incidence in brain tissue.
Several groups of rats were treated with dipyridamol and dihydroergotoxine methane sulphonate and their association. Their clinical constants were then monitored and their brain tissue examined by optical microscopy. This study indicates that the association has a remarkable effect on the pO2, maintaining the level of 2,3-diphosphoglycerate concentration, and moreover a vasodilatory action, facilitating a better supply of oxygen to the cerebral cells. The results show the advantage of these drugs in treating cerebral vascular disease.
D019794:2,3-Diphosphoglycerate; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects / Q000378:metabolism*; D002245:Carbon Dioxide / Q000378:metabolism; D004088:Dihydroergotoxine / Q000494:pharmacology*; D004163:Diphosphoglyceric Acids / Q000378:metabolism; D004176:Dipyridamole / Q000494:pharmacology*; D004347:Drug Interactions; D006400:Hematocrit; D006863:Hydrogen-Ion Concentration; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D001639:Bicarbonates; D004163:Diphosphoglyceric Acids; D004088:Dihydroergotoxine; D019794:2,3-Diphosphoglycerate; D002245:Carbon Dioxide; D004176:Dipyridamole