title: [Poly-(ADP ribose) synthesis and regulation disorders in disease].
abstract: Poly(ADP-ribose) is a polyanion involved in the regulation of the DNA metabolism of cells. DNA repair, semiconservative DNA-synthesis, differentiation- and trans-formation functions are connected to changes in the activity of the poly(ADP-ribose)-polymerase. The incidence of most cancers shows a steady increase with age while the PAR-synthesis decreases linear in certain cells with age. In some diseases abnormalities could be detected in PAR-synthesis and binding to nuclear proteins.
mesh_terms: D000367:Age Factors; D000368:Aged; D001260:Ataxia Telangiectasia / Q000201:enzymology; D001816:Bloom Syndrome / Q000201:enzymology; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D003057:Cockayne Syndrome / Q000201:enzymology; D004247:DNA / Q000378:metabolism; D004260:DNA Repair; D005199:Fanconi Anemia / Q000201:enzymology; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000201:enzymology; D008875:Middle Aged; D009702:Nucleoside Diphosphate Sugars / Q000378:metabolism*; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism; D012595:Scleroderma, Systemic / Q000201:enzymology; D013167:Spondylitis, Ankylosing / Q000201:enzymology; D014983:Xeroderma Pigmentosum / Q000201:enzymology
chemical_list: D009702:Nucleoside Diphosphate Sugars; D011064:Poly Adenosine Diphosphate Ribose; D004247:DNA; D011065:Poly(ADP-ribose) Polymerases
vernacular_title: Poly-(ADP-Ribose-)Synthese und Regulationsstörungen bei Erkrankungen.