Renal function following nephroangiography with diatrizoate. Effects of saline, mannitol, and diatrizoate on renal blood flow, glomerular permeability and filtration rate and diuresis in dogs.
The ionic contrast medium diatrizoate used in high-dose unilateral nephroangiography in dogs produced an abnormal nephrogram, 'patchy contrast medium retention', and a marked decrease in renal blood flow in five of eight injected kidneys. Increased glomerular permeability (albuminuria), reduced glomerular filtration rate (creatinine clearance), and reduced osmotic diuresis were demonstrated in all selectively injected kidneys.
D000419:Albuminuria; D000818:Animals; D003404:Creatinine / Q000378:metabolism; D003973:Diatrizoate / Q000009:adverse effects / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology*; D007677:Kidney Function Tests; D008353:Mannitol / Q000494:pharmacology; D011859:Radiography; D012077:Renal Artery / Q000000981:diagnostic imaging*; D012079:Renal Circulation / Q000187:drug effects; D012965:Sodium Chloride / Q000494:pharmacology
D003973:Diatrizoate; D008353:Mannitol; D012965:Sodium Chloride; D003404:Creatinine