title: Changes in morphometric parameters and the characteristics of collagen following thyroxine and thiourea treatments in young male garden lizards.
abstract: Administration of both thyroxine (1 microgram/g body wt) and thiourea (0.5 mg/10 g body wt) to young male garden lizards for a period of 2 weeks led to changes in morphometric/biochemical parameters. Percentages of increase in body weight and snout-to-vent length of thyroxine-treated lizards during this period were significantly lower than the percentages of increase observed in control lizards. Thiourea-induced inhibition of increase in body weight was marginal but not significant statistically. The total collagen content of tendons decreased upon thyroxine treatment and increased following thiourea administration. Thyroxine treatment led to an increase in salt solubility of bone and skin collagens and thiourea showed a reverse effect. On the other hand, the acid solubility of tendon collagen increased after thyroxine administration and decreased following thiourea treatment.
mesh_terms: D000375:Aging / Q000187:drug effects; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003094:Collagen / Q000032:analysis / Q000378:metabolism*; D008116:Lizards / Q000254:growth & development*; D008297:Male; D012995:Solubility; D013890:Thiourea / Q000494:pharmacology*; D013974:Thyroxine / Q000494:pharmacology* / Q000502:physiology
chemical_list: D003094:Collagen; D013890:Thiourea; D013974:Thyroxine