Simplified gentamicin dosing in neonates: a time- and cost-efficient approach.
A nomogram-based method for monitoring gentamicin therapy in neonates was developed and evaluated prospectively. Gentamicin dosage adjustment, based on analysis of a single blood sample collected between 8 and 12 hours after dose administration, resulted in satisfactory serum levels in 79% of the neonates. When compared to dosage adjustment methods requiring multiple blood samples, the nomogram method is a cost-effective and time-efficient technique for screening the appropriateness of gentamicin dosages in neonates.
D001424:Bacterial Infections / Q000188:drug therapy*; D003362:Cost-Benefit Analysis; D005839:Gentamicins / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007231:Infant, Newborn; D011446:Prospective Studies; D012189:Retrospective Studies; D013997:Time Factors
D005839:Gentamicins