Effect of cloned interferon-gamma on expression of H-2 and Ia antigens on cell lines of hemopoietic, lymphoid, epithelial, fibroblastic and neuronal origin.
Interferon-gamma (IFN-gamma), tested in the form of the product of a cloned murine IFN-gamma gene, was found to increase the expression of H-2 antigens on cultured cell lines of a wide variety of cell types including factor-dependent hemopoietic cells, pre-B and B cells, macrophages, T cells, mast cells and cell lines of epithelial, fibroblastic and neuronal origin. However, IFN-gamma induced Ia antigens on only B cells, macrophages and T-dependent mast cells or persisting cells. On the basis of these results, we suggest that a major function of IFN-gamma is to potentiate immune responses by enhancing the expression of H-2 and Ia antigens on a variety of cell types.
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology; D002460:Cell Line; D002999:Clone Cells; D004912:Erythrocytes / Q000187:drug effects; D005347:Fibroblasts / Q000187:drug effects; D006649:Histocompatibility Antigens / Q000235:genetics*; D000949:Histocompatibility Antigens Class II; D007371:Interferon-gamma / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D009447:Neuroblastoma / Q000276:immunology; D009474:Neurons / Q000187:drug effects
D000954:Antigens, Surface; D006649:Histocompatibility Antigens; D000949:Histocompatibility Antigens Class II; D007371:Interferon-gamma