Platelet adherence to bioprosthetic cardiac valves.
Tissue from porcine aortic bioprosthetic valves (Hancock) and bovine pericardial valves (Ionescu-Shiley) were incubated with platelets tagged with chromium-51. There was a significantly decreased platelet-collagen adhesion reaction in both porcine and bovine glutaraldehyde-treated valves compared with reactions in fresh porcine aortic valve and fresh bovine pericardium (p less than 0.001). There was no significant difference in the platelet-collagen reaction between porcine aortic valve and bovine pericardium, whether treated with glutaraldehyde or in the fresh state (p greater than 0.05). The addition of aspirin did not significantly decrease the platelet-collagen reaction on glutaraldehyde-treated or fresh valves (p greater than 0.05). Rinsing fresh valves in plasma appeared to offer more protection against platelet adhesion than rinsing them in saline solution (p less than 0.01). It is concluded that there is no difference in platelet adherence to porcine aortic valve or bovine pericardium and that glutaraldehyde, and perhaps plasma, offers a protective effect against platelet adhesion.
D000818:Animals; D001021:Aortic Valve; D001241:Aspirin / Q000494:pharmacology; D001705:Bioprosthesis; D001792:Blood Platelets / Q000187:drug effects; D002417:Cattle; D005976:Glutaral / Q000494:pharmacology; D006350:Heart Valve Prosthesis; D006801:Humans; D008854:Microscopy, Electron; D010973:Platelet Adhesiveness; D013552:Swine
D001241:Aspirin; D005976:Glutaral