title: [Epileptic syndrome in children with closed craniocerebral injuries (role of genetic and environmental factors)].
abstract: An examination of 450 children with closed craniocerebral trauma ( CCCT ) revealed epileptic attacks developing at different time intervals following the injury in 54 children (12%). Hereditary predisposition to the development of the posttraumatic epileptic syndrome (ES) was ascertained. Perinatal adverse events, infections and other detrimental exposures contribute to the formation of the epileptic readiness of the brain. The head injury plays the role of the resolving exogenous factor inducing the disease with a low penetration of the pathological hereditary factor. Thus, both exogenous and genetic factors play an important role in the formation of the ES following CCCT .
mesh_terms: D000293:Adolescent; D000437:Alcoholism / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D004775:Enuresis / Q000235:genetics; D004834:Epilepsy, Post-Traumatic / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008881:Migraine Disorders / Q000235:genetics; D010375:Pedigree; D012893:Sleep Wake Disorders / Q000235:genetics
vernacular_title: Epilepticheskiĭ sindrom u deteĭ s zakrytoĭ cherepno-mozgovoĭ travmoĭ (rol' geneticheskikh i sredovykh faktorov).