title: Toxicity and association of polycyanoacrylate nanoparticles with hepatocytes.
abstract: The degradation of polybutylcyanoacrylate (PBC) and polyhexylcyanoacrylate (PHC) nanoparticles, together with their association with and toxicity towards isolated hepatocytes, were determined. Nanoparticles were not taken up by rat hepatocytes at a significant level. The LD50S of PBC and PHC nanoparticles towards hepatocytes were 0.4 mg/2 x 10(6) cells and greater than 1 mg/2 x 10(6) cells respectively. This hepatocyte toxicity cannot be attributed solely to the formaldehyde formed during degradation.
mesh_terms: D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D003487:Cyanoacrylates / Q000378:metabolism / Q000493:pharmacokinetics / Q000633:toxicity*; D004337:Drug Carriers / Q000633:toxicity; D004659:Enbucrilate; D005557:Formaldehyde / Q000096:biosynthesis / Q000633:toxicity*; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008863:Microspheres; D009942:Organometallic Compounds / Q000494:pharmacology; D015125:Oxyquinoline / Q000031:analogs & derivatives / Q000494:pharmacology; D010316:Particle Size; D011108:Polymers / Q000378:metabolism / Q000493:pharmacokinetics / Q000633:toxicity*; D051381:Rats
chemical_list: D003487:Cyanoacrylates; D004337:Drug Carriers; D009942:Organometallic Compounds; D011108:Polymers; C032950:indium oxine; D005557:Formaldehyde; C042633:poly(hexyl-2-cyanoacrylate); D015125:Oxyquinoline; D004659:Enbucrilate