Localization of gold in the anterior pituitary gland of rats exposed to sodium aurothiomalate.
The ultrastructural localization of gold in the anterior pituitary of rats injected intraperitoneally with sodium aurothiomalate has been demonstrated using a histochemical technique that visualizes minute traces of gold. Gold was located intracellularly within lysosome-like bodies of marginal layer cells, follicular cells, and thyrotrophs. Gold was not seen within secretion granules. The possible mechanism by which gold is taken up into the cells is discussed.
D000818:Animals; D005260:Female; D006046:Gold / Q000378:metabolism*; D006052:Gold Sodium Thiomalate / Q000378:metabolism*; D006651:Histocytochemistry; D008247:Lysosomes / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D010903:Pituitary Gland, Anterior / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D013972:Thyrotropin / Q000378:metabolism
D006052:Gold Sodium Thiomalate; D006046:Gold; D013972:Thyrotropin