title: A renal lesion in ankylosing spondylitis.
abstract: 2 patients with ankylosing spondylitis (A Sp) were found to have renal lesions similar to those seen in IgA nephropathy. In 1 patient the changes were extremely severe and progressive and in the other they were mild. Vascular changes were also noted in 1 patient. The findings suggest an immune complex mediated glomerulonephritis and support an earlier report that there may be a specific renal lesion in patients with A Sp. The significance of IgA deposition in the mesangium, and of an increase in the serum levels of IgA in some patients with A Sp is unclear.
mesh_terms: D000328:Adult; D005921:Glomerulonephritis / Q000150:complications* / Q000209:etiology / Q000276:immunology; D006801:Humans; D007105:Immune Complex Diseases / Q000150:complications; D007070:Immunoglobulin A / Q000302:isolation & purification; D008297:Male; D013167:Spondylitis, Ankylosing / Q000150:complications*
chemical_list: D007070:Immunoglobulin A