[Biochemical aspects of myelinogenesis in the peripheral nervous system].
The excised sciatic nerve of the trembler mouse synthesizes minute amounts of C20 and C22 saturated fatty acids as compared to the normal PNS. No lignoceric acid synthesis is observed. The microsomal fraction contains however an elongase able to synthesize with nearly normal levels the saturated very long chain fatty acids.
D000214:Acyl Coenzyme A / Q000378:metabolism; D000818:Animals; D005227:Fatty Acids / Q000096:biosynthesis*; D008316:Malonyl Coenzyme A / Q000378:metabolism; D051379:Mice; D008818:Mice, Neurologic Mutants; D008861:Microsomes / Q000378:metabolism; D009186:Myelin Sheath / Q000378:metabolism*; D010525:Peripheral Nerves / Q000378:metabolism*; D012584:Sciatic Nerve / Q000378:metabolism / Q000648:ultrastructure; D013229:Stearic Acids / Q000378:metabolism
D000214:Acyl Coenzyme A; D005227:Fatty Acids; D013229:Stearic Acids; C017725:stearoyl-coenzyme A; D008316:Malonyl Coenzyme A
Aspects biochimiques de la myélinogenèse dans le système nerveux périphérique.