[Role of serotonin in the diffuse inhibitory controls induced by nociceptive stimulation].
In the anaesthetized Rat, the entire population of dorsal horn convergent neurones is differentially affected by a noxious stimulus: while exciting the segmental pool, it strongly inhibits the remaining population. The inhibitory effects, which involve supraspinal mechanisms, are reduced to a great extent in parachlorophenylalanine pretreated animals. The role of raphé-spinal serotonergic pathways in nociception is discussed.
D000818:Animals; D010134:Fenclonine / Q000494:pharmacology; D008297:Male; D009433:Neural Inhibition; D009434:Neural Pathways / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D012701:Serotonin / Q000502:physiology*; D013126:Spinal Nerve Roots / Q000502:physiology*
D012701:Serotonin; D010134:Fenclonine
Rôle de la sérontonine dans les contrôles inhibiteurs diffus induits par des stimulations nociceptives.