title: Lowered rates of protein synthesis by mitochondria isolated from organisms of increasing age.
abstract: The rate of protein synthesis was measured in isolated mitochondria from Drosophila melanogaster and from the livers and kidneys of C57BL/6J mice of increasing ages. Over the life-span of the organisms, the synthesis of mitochondrial proteins decreased to a level which was less than half the original rate. Concomitant with this decrease, the amount of mitochondria which could be isolated from the organisms declined by about 30%. Thus, the separate translational system of mitochondria exhibited an age-related decrease in activity which was in addition to the decrease already observed in the cytoplasmic ribosomal system.
mesh_terms: D000375:Aging; D000818:Animals; D004331:Drosophila melanogaster / Q000378:metabolism; D005260:Female; D007668:Kidney / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008928:Mitochondria / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism; D014176:Protein Biosynthesis