title: Improvement of cerebral blood flow and/or CO2 reactivity after superficial temporal artery-middle cerebral artery bypass in patients with transient ischemic attacks and watershed-zone infarctions.
abstract: The effect of extracranial-intracranial bypass anastomosis on cerebral blood flow and CO2 reactivity during hypocapnia was investigated in ten patients with transient ischemic attacks or watershed infarctions due to carotid occlusive diseases. Six patients had occlusion and four had stenosis (greater than 50%) of the internal carotid artery. Those with infarctions had increased cerebral blood flow and CO2 reactivity postoperatively, and improved clinically. Those with transient ischemic attacks due to stenosis (greater than 50%) of the internal carotid artery had increased CO2 reactivity postoperatively but constant normal regional blood flow. Cerebral blood flow improved in those with poorer flow, CO2 reactivity increased in those with better reactivity, and better CO2 reactivity preoperatively brought about a greater flow increase. The pre- and postoperative evaluation of cerebral blood flow and CO2 reactivity is believed to be useful in evaluating the effectiveness of bypass anastomosis. Preoperative evaluation might be informative in selecting candidates for bypass.
mesh_terms: D000368:Aged; D001157:Arterial Occlusive Diseases / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery; D001921:Brain / Q000378:metabolism; D002245:Carbon Dioxide / Q000378:metabolism; D002340:Carotid Artery Diseases / Q000378:metabolism / Q000503:physiopathology; D002343:Carotid Artery, Internal; D002544:Cerebral Infarction / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery; D002560:Cerebrovascular Circulation; D003251:Constriction, Pathologic / Q000378:metabolism / Q000503:physiopathology; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000378:metabolism / Q000503:physiopathology* / Q000601:surgery; D008297:Male; D008875:Middle Aged
chemical_list: D002245:Carbon Dioxide