Lipoprotein levels during hormone replacement therapy by vaginal ring pessaries.
Nineteen women who had had a surgical menopause had a vaginal ring pessary containing levonorgestrel and oestradiol in situ for a period of 3 months. Fasting lipoprotein levels were measured before, and after 1 and 3 months on therapy. After 3 months total triglyceride levels were significantly lower than baseline values (P less than 0.01) as were very-low-density-lipoprotein cholesterol (P less than 0.01), low-density-lipoprotein cholesterol (P less than 0.05) and high-density-lipoprotein cholesterol (P less than 0.001) levels. These changes suggest that in this preparation the effects of the progestogen component are dominant.
D000328:Adult; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage / Q000494:pharmacology; D004338:Drug Combinations; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D016912:Levonorgestrel; D008074:Lipoproteins / Q000097:blood*; D008593:Menopause / Q000187:drug effects*; D008875:Middle Aged; D009644:Norgestrel / Q000008:administration & dosage / Q000494:pharmacology*; D010570:Pessaries
D003277:Contraceptives, Oral, Combined; D004338:Drug Combinations; D008074:Lipoproteins; D009644:Norgestrel; D004958:Estradiol; D016912:Levonorgestrel