Experimental induction of oral squamous cell carcinomas in mice with 4-nitroquinolone-1-oxide.
The oral mucosa of mice is resistant to the action of a variety of carcinogens. In this study, the water-soluble carcinogen 4-nitroquinoline-1-oxide (4NQO) was applied repeatedly to the palates of male CBA mice for 2, 4, 6, 8, 12, or 16 weeks, and the animals were observed for the remainder of the 50-week experimental period. Oral epithelial atypia and squamous cell carcinoma were observed with increasing prevalence as the period of carcinogen exposure was increased. Carcinomas developed by 50 weeks in all animals that received 4NQO for 16 weeks.
D015112:4-Nitroquinoline-1-oxide / Q000009:adverse effects*; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology; D009062:Mouth Neoplasms / Q000139:chemically induced* / Q000473:pathology; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009600:Nitroquinolines / Q000009:adverse effects*; D010157:Palatal Neoplasms / Q000139:chemically induced / Q000473:pathology; D013997:Time Factors; D014062:Tongue Neoplasms / Q000139:chemically induced / Q000473:pathology
D009600:Nitroquinolines; D015112:4-Nitroquinoline-1-oxide