[Cytochrome P-450 induction in the liver of rats exposed to polychlorinated biphenyls].
Administration of a mixture of polychlorinated diphenyls (sovol) to rats per os induces a dramatic rise in the liver content of cytochrome P-450. To attain the maximal induction effect, it is sufficient to make a single drug injection in a dose of 500 mg/kg. Further raising of the sovol dose as well as its repeated injections do not exert any substantial effect on the index of hemoprotein induction. Alterations in liver cytochrome P-450 content following a single injection of sovol persist for 40 days. In female rats, the induction effect of sovol is less pronounced than in male rats.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008099:Liver / Q000032:analysis / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013053:Spectrophotometry; D013997:Time Factors
D003577:Cytochrome P-450 Enzyme System; D011078:Polychlorinated Biphenyls
Induktsiia tsitokhroma P-450 v pecheni krys pri vozdeĭstvii polikhlorirovannykh difenilov.