Cyclophosphamide induction of splenic suppressor cells in hamsters.
Injection of hamsters with a single sublethal dose of cyclophosphamide induced splenic atrophy followed by considerable hypertrophy. During the splenomegaly phase, the in vitro reactivity of spleen cells to concanavalin A (ConA) or protein A (ProtA) was decreased. The spleens of 6-8-month old animals contained cells able to suppress the in vitro reactivity of normal lymphocytes to ConA or ProtA. These cells were absent in 2-month old animals, and some suppressor activity could be shown in 3-month old hamsters. Suppressor activity was abolished by removal of adherent cells and by silica treatment, but antisera against thymocytes or IgG were ineffective.
D000375:Aging; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002448:Cell Adhesion; D002455:Cell Division; D006224:Cricetinae; D003520:Cyclophosphamide / Q000494:pharmacology*; D007700:Kinetics; D008214:Lymphocytes / Q000166:cytology; D013154:Spleen / Q000276:immunology* / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013936:Thymidine / Q000378:metabolism
D003520:Cyclophosphamide; D013936:Thymidine