Effect of gold salts, D-penicillamine and benoxaprofen on type II collagen-induced arthritis in rats.
We investigated the therapeutic effect of two gold salts, gold sodium thiomalate (GST, i.m.) and auranofin (p.o.), D-penicillamine (p.o.) and benoxaprofen (p.o.) in rat collagen-induced arthritis using type II collagen from fetal bovine articular cartilage. GST, but not auranofin, reduced hind paw edema and bone pathology. However, auranofin reduced serum copper and zymosan-induced prostaglandin production from peritoneal macrophages. In contrast, GST increased both serum copper and macrophage prostaglandin production by zymosan. Benoxaprofen reduced both hind paw edema and pathology, whereas D-penicillamine was without effect. None of these treatments influenced the circulating level of antibody to type II collagen.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000906:Antibodies / Q000032:analysis; D001168:Arthritis / Q000139:chemically induced* / Q000276:immunology; D001310:Auranofin; D006051:Aurothioglucose / Q000031:analogs & derivatives / Q000494:pharmacology; D003094:Collagen / Q000276:immunology; D003300:Copper / Q000097:blood; D003967:Diarrhea / Q000139:chemically induced; D006052:Gold Sodium Thiomalate / Q000494:pharmacology; D008297:Male; D010396:Penicillamine / Q000494:pharmacology; D011422:Propionates / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D000906:Antibodies; D011422:Propionates; D006052:Gold Sodium Thiomalate; C011677:benoxaprofen; D006051:Aurothioglucose; D001310:Auranofin; D003300:Copper; D003094:Collagen; D010396:Penicillamine