An involvement of acetylcholine in object discrimination learning and memory in the marmoset.
Five marmosets (Callithrix jacchus) were tested, using a Wisconsin General Test Apparatus, on a series of junk object visual discrimination tasks, including new learning, 24-hr reversal and 24-hr retention. The effects of administering the cholinergic receptor blocking agent, scopolamine either just before or immediately after the new learning task, or just before the 24-hr reversal and retention tasks, were assessed. Results suggest that scopolamine impairs new learning and impairs the encoding of new information in long term memory. Some evidence of a mild retrieval deficit under scopolamine was also seen, while state-dependent effects were not apparent.
D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000502:physiology; D002086:Butylscopolammonium Bromide / Q000494:pharmacology; D002143:Callitrichinae; D004193:Discrimination Learning / Q000187:drug effects / Q000502:physiology*; D005556:Form Perception / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008568:Memory / Q000502:physiology*; D011939:Mental Recall / Q000502:physiology*; D012153:Retention, Psychology / Q000187:drug effects / Q000502:physiology; D012193:Reversal Learning / Q000502:physiology; D012602:Scopolamine Derivatives / Q000494:pharmacology
D012602:Scopolamine Derivatives; D002086:Butylscopolammonium Bromide; D000109:Acetylcholine