[Pertussis vaccine as an inducer of suppressor cells inhibiting the local graft versus host reaction].
The formation of nonspecific suppressor cells inhibiting the development of the graft versus host (GvH) reaction is shown to occur in the spleen of CBA mice after the injection of pertussis vaccine. 2 splenocyte populations have been found to possess suppressing activity: one of them comprises the splenocytes sensitive to anti-theta serum, carrying no receptors to IgG and IgM on their surface and incapable of adherence to the plastic surface; the splenocytes in the other population adhere to the plastic surface. During incubation and in vitro contact with the allogenic cells of intact donors the suppressor splenocytes release soluble mediators capable of suppressing the GvH reaction.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D002454:Cell Differentiation / Q000187:drug effects; D006087:Graft vs Host Reaction / Q000187:drug effects*; D006824:Hybridization, Genetic; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010567:Pertussis Vaccine / Q000494:pharmacology*; D011971:Receptors, Immunologic / Q000032:analysis; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000637:transplantation*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects*
D000961:Antilymphocyte Serum; D010567:Pertussis Vaccine; D011971:Receptors, Immunologic
Vaktsina protiv kokliusha kak induktor kletok-supressorov, ugnetaiushchikh mestnuiu reaktsiiu transplantat protiv khoziaina.