Chromosome rearrangements in oncogenesis.
Chromosomal studies have earlier provided evidence for the clonal nature of most neoplasms, and for the role of sequential genetic change in tumour progression. Now, in combination with molecular techniques, they are indicating how the function of specific genes (oncogenes) can be significantly altered by chromosomal translocations or by gene amplification, contributing to carcinogenesis.
D002051:Burkitt Lymphoma / Q000235:genetics; D002869:Chromosome Aberrations; D005784:Gene Amplification; D015321:Gene Rearrangement; D006801:Humans; D007938:Leukemia / Q000235:genetics; D008223:Lymphoma / Q000235:genetics; D009369:Neoplasms / Q000235:genetics*; D009857:Oncogenes; D014178:Translocation, Genetic