Spasmogenic activity of C5adesArg anaphylatoxin on guinea pig lung parenchymal strips: sensitivity of the leukotriene-mediated component to cyclooxygenase inhibitors.
The leukotriene-dependent component of C5adesArg-induced contractile activity on guinea pig lung parenchymal strips is inhibited by cyclooxygenase inhibitors. Indomethacin simultaneously increased leukotriene release while inhibiting both cyclooxygenase-dependent mediator release and the contractile force generated. Tissue responses to LTC4 and LTD4 are also inhibited by cyclooxygenase blockade, while contractions induced by the thromboxane A2 analog, U-46619, histamine or acetylcholine are not affected. These data indicate a functional role for cyclooxygenase metabolites in leukotriene-induced contractile responses in lung.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology; D003182:Complement C5 / Q000031:analogs & derivatives* / Q000494:pharmacology; D015937:Complement C5a, des-Arginine; D016861:Cyclooxygenase Inhibitors; D015237:Dinoprost; D015232:Dinoprostone; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007093:Imidazoles / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D008168:Lung / Q000187:drug effects*; D009119:Muscle Contraction / Q000187:drug effects; D010894:Piroxicam; D011458:Prostaglandins E / Q000378:metabolism; D011460:Prostaglandins F / Q000378:metabolism; D013189:SRS-A / Q000494:pharmacology*; D013843:Thiazines / Q000494:pharmacology; D013929:Thromboxane B2 / Q000378:metabolism
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003182:Complement C5; D015937:Complement C5a, des-Arginine; D016861:Cyclooxygenase Inhibitors; D007093:Imidazoles; D011458:Prostaglandins E; D011460:Prostaglandins F; D013189:SRS-A; D013843:Thiazines; C029166:dazoxiben; D010894:Piroxicam; D013929:Thromboxane B2; D015237:Dinoprost; D015232:Dinoprostone; D001241:Aspirin; D007213:Indomethacin