[Effect of carbamate pesticides on the induction of hepatic enzymes of the rat and on the microsomal phospholipid changes].
The influence of two carbamine pesticides i.e., manebe and carbaryl upon the hepatic microsomal enzymes induction in the rat was studied. Both substances, when administered by themselves, affect only slightly liver weight, P 450 cytochrome rates and bilirubin glucuronosyltransferase, in the microsome fraction of the hepatic homogenate. It seems, however, that carbaryl is involved in producing a slight induction, whereas manebe acts inversely. Yet, manebe changes largely the induction effects of phenobarbital when associated with the latter. In the animal treated simultaneously with manebe and phenobarbital, the increase in the rate of hepatic microsomal P 450 cytochrome as well as the variations in the distribution of fatty acids in phospholipids, are significantly lower than in the animal solely treated with phenobarbital.
D015660:7-Alkoxycoumarin O-Dealkylase; D000818:Animals; D012721:Carbaryl / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004790:Enzyme Induction; D005227:Fatty Acids / Q000032:analysis; D014453:Glucuronosyltransferase / Q000378:metabolism; D008297:Male; D008344:Maneb / Q000494:pharmacology*; D008345:Manganese / Q000378:metabolism; D008862:Microsomes, Liver / Q000201:enzymology* / Q000378:metabolism; D010105:Oxygenases / Q000378:metabolism; D010634:Phenobarbital / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000378:metabolism; D013859:Thiocarbamates / Q000494:pharmacology*
D005227:Fatty Acids; D013859:Thiocarbamates; D008344:Maneb; D008345:Manganese; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D015660:7-Alkoxycoumarin O-Dealkylase; D013482:Superoxide Dismutase; D014453:Glucuronosyltransferase; D012721:Carbaryl; D010634:Phenobarbital
Etude de l'influence des pesticides carbamines sur l'induction des enzymes hépatiques du rat et sur les modifications des phospholipides microsomaux.