Effect of treatment with different doses of bromocriptine on plasma profiles of prolactin, gonadotrophins and testosterone in mature male rats and mice.
The influence of different doses of bromocriptine (CB-154) on plasma levels of prolactin (Prl), FSH, LH and testosterone (T) in mature male rats and mice was studied. Daily subcutaneous administration of 360 micrograms of CB-154 in sesame oil was sufficient to induce maximal suppression of plasma Prl levels in mature male rats whilst subcutaneous implantation of two pellets of CB-154 and cholesterol, each containing approximately 6 mg CB-154, was effective in suppressing serum Prl levels in mature rats for at least four weeks. This was accompanied by a significant elevation of plasma levels of LH and FSH. A similar dose-response study in mature male mice suggested that relatively higher doses of CB-154 are required to suppress plasma levels of Prl in this species, although large doses of CB-154 can still increase plasma levels of gonadotrophins and T in male mice.
D000818:Animals; D001971:Bromocriptine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004343:Drug Implants; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007016:Hypophysectomy; D007279:Injections, Subcutaneous; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D051379:Mice; D011388:Prolactin / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000097:blood*
D004343:Drug Implants; D001971:Bromocriptine; D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone