title: Effect of chemoreceptor and pulmonary receptor stimulation on dilator nares EMG activity in the dog.
abstract: To define the relationship between central control of upper airway muscles and respiratory muscle function, the electromyographic responses of the dilator nares muscles to stimulation of chemoreceptors and pulmonary receptors were studied in six anesthetized dogs. Only at maximal levels of hypoxia was the inspiratory activity of the dilator nares significantly increased. Hypercapnic stimulation increased the inspiratory activity with each incremental increase in CO2. Pulmonary stretch receptor stimulation produced by lung inflation inhibited dilator nares activity. Pulmonary irritant receptor stimulation by intravenously administered histamine increased dilator nares activity, as did pulmonary J receptor stimulation by the intravenous administration of capsaicin.
mesh_terms: D000818:Animals; D002211:Capsaicin / Q000494:pharmacology; D002245:Carbon Dioxide; D002628:Chemoreceptor Cells / Q000187:drug effects / Q000503:physiopathology*; D004285:Dogs; D004576:Electromyography; D005152:Facial Muscles / Q000294:innervation*; D006632:Histamine / Q000494:pharmacology; D006935:Hypercapnia / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology; D008465:Mechanoreceptors / Q000187:drug effects / Q000503:physiopathology*; D009666:Nose / Q000503:physiopathology*; D011661:Pulmonary Stretch Receptors / Q000187:drug effects / Q000503:physiopathology*; D013268:Stimulation, Chemical
chemical_list: D002245:Carbon Dioxide; D006632:Histamine; D002211:Capsaicin