[In vivo and in vitro effect of trehalose dimycolate on tumoricidal activity of peritoneal macrophages from rats].
Trehalose dimycolate (TDM), a well-defined component of Mycobacterium tuberculosis cell wall has been tested in vivo and in vitro for its effect on the tumoricidal activity of Rat peritoneal macrophages. Macrophages could be rendered cytolytic against syngeneic tumor cells by an intraperitoneal injection of an aqueous suspension of TDM. However, as we failed to render them tumoricidal in vitro, we consider that the activation process is not due to a direct effect on macrophages.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D002470:Cell Survival; D003311:Cord Factors / Q000008:administration & dosage / Q000494:pharmacology*; D006017:Glycolipids / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008262:Macrophage Activation / Q000187:drug effects; D008264:Macrophages / Q000276:immunology*; D009369:Neoplasms / Q000473:pathology*; D051381:Rats
D000970:Antineoplastic Agents; D003311:Cord Factors; D006017:Glycolipids
Effet in vivo et in vitro du dimycolate de tréhalose (TDM) sur l'activité tumoricide des macrophages péritonéaux de rats.