Comparison of atropine with ipratropium bromide in patients with reversible airways obstruction unresponsive to salbutamol.
Dose-response curves for atropine and ipratropium bromide were made in nine asthmatics unresponsive to salbutamol. Conventional doses of ipratropium resulted in significantly less bronchodilatation than large doses of atropine, suggesting that larger doses of ipratropium should be used.
D000328:Adult; D000420:Albuterol / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001285:Atropine / Q000627:therapeutic use*; D001286:Atropine Derivatives / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D005541:Forced Expiratory Volume; D006801:Humans; D009241:Ipratropium / Q000627:therapeutic use*; D008176:Lung Volume Measurements; D008875:Middle Aged
D001286:Atropine Derivatives; D001285:Atropine; D009241:Ipratropium; D000420:Albuterol