HLA DR typing of aspirin sensitive asthmatics.
Previous studies have suggested associations of HLA, A, B and C loci antigens with specific subgroups of asthma. We applied DR antigen typing to the aspirin sensitive subgroup to look for similar correlations. Our results show no statistically significant increase in any known DR antigen nor any correlation with A or B locus typing. We did find a non-statistically significant increase in the number of subjects with blank typing at the DR locus, (i.e., a presently unidentified antigen), raising the question of whether a correlation may exist with an as yet undefined antigen.
D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000235:genetics / Q000276:immunology*; D001986:Bronchial Spasm / Q000139:chemically induced / Q000276:immunology; D004198:Disease Susceptibility; D004342:Drug Hypersensitivity / Q000235:genetics / Q000276:immunology*; D005260:Female; D005802:Genes, MHC Class II; D006684:HLA-DR Antigens; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male
D006684:HLA-DR Antigens; D001241:Aspirin