title: Influence of lesions in the limbic-hypothalamic system on metabolic response of acetate to daily repeated heat exposure in rabbit.
abstract: The effects of lesions in the basal medial hypothalamus and limbic structure on the acetate metabolic responses to daily repeated heat exposure in the liver of rabbits have been investigated. The results obtained were summarized as follows: (1) THe acetate metabolic responses to the 1st heat exposure (heat exposure on the 1st day) were altered by the lesions in the periventricular arcuate nucleus (ARC), ventromedial hypothalamus (VMH), stria terminalis (ST) and dorsal fornix (FX). (2) The acetate metabolic responses to heat exposure were completely abolished by the ten times repetition of heat exposure in the rabbits with lesions in ARC or VMH. They were similar to sham-operated animals. (3) The acetate metabolic responses to heat exposure remained even after the ten times repetition of heat exposure in the rabbits with lesions in ST and FX indicating the differences from sham-operated animals. (4) From these results, it might be suggested that the basal medial hypothalamus and limbic structure participated in the mechanism of acetate metabolic response to the 1st heat exposure, but only these limbic structure played some roles in the complete disappearance process of acetate metabolic responses to heat exposure by the ten times repetition of heat exposure.
mesh_terms: D000085:Acetates / Q000378:metabolism*; D019342:Acetic Acid; D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D002250:Carbon Radioisotopes; D005260:Female; D005947:Glucose / Q000378:metabolism; D006358:Hot Temperature; D007031:Hypothalamus / Q000502:physiology*; D007657:Ketone Bodies / Q000378:metabolism; D008032:Limbic System / Q000502:physiology*; D050356:Lipid Metabolism; D011817:Rabbits
chemical_list: D000085:Acetates; D002250:Carbon Radioisotopes; D007657:Ketone Bodies; D002245:Carbon Dioxide; D005947:Glucose; D019342:Acetic Acid