Anti-leprosy vaccines--field trials and future prospects.
Development of a vaccine for prevention of leprosy is today one of the major challenges for bio-medical sciences. Two vaccines containing (i) M. leprae + BCG and (ii) ICRC, a cultivable mycobacterium, have reached advanced stage with reference to human trials. This article describes comparative features of two vaccines and mechanism of their action. Future possibilities with reference to anti-leprosy vaccine are also discussed.
D000818:Animals; D001500:BCG Vaccine / Q000494:pharmacology*; D001428:Bacterial Vaccines / Q000494:pharmacology*; D005069:Evaluation Studies as Topic; D000882:Haplorhini; D006801:Humans; D007111:Immunity, Cellular; D007167:Immunotherapy; D007918:Leprosy / Q000276:immunology / Q000628:therapy*; D051379:Mice; D009162:Mycobacterium avium / Q000276:immunology; D009166:Mycobacterium leprae / Q000276:immunology*
D001500:BCG Vaccine; D001428:Bacterial Vaccines