Chemotherapy by bronchial arterial infusion for pulmonary metastases of renal cell carcinoma.
Bilateral multiple pulmonary metastases of renal cell carcinoma were treated by repeated bronchial arterial infusion of chemotherapeutic drugs, such as mitomycin C, carboquone, doxorubicin and nitrosourea. Of 12 patients treated 2 had a complete response, 3 had a partial response, 2 had no change and 5 had progression of the disease. The over-all response rate was 42 per cent. Since metastatic renal cell carcinoma is unresponsive to ordinary treatment bronchial arterial infusion alone or in combination with an operation appears promising.
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002225:Carbazilquinone / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial; D007680:Kidney Neoplasms / Q000188:drug therapy*; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage; D009603:Nitroso Compounds / Q000008:administration & dosage
D000970:Antineoplastic Agents; D008937:Mitomycins; D009603:Nitroso Compounds; D002225:Carbazilquinone; D016685:Mitomycin; D004317:Doxorubicin