Alpha heavy-chain disease presenting as goiter.
A patient with alpha heavy-chain disease (alpha HCD) originally had presented with a goiter from an extramedullary plasmacytoma. Alpha HCD was diagnosed by both standard laboratory procedures and high-resolution two-dimensional gel electrophoresis. The fragment of the alpha chain had a molecular weight of 38,000 and consisted of seven major charge forms, with an isoelectric point range of 5.2-5.6. Since alpha HCD usually involves the gastrointestinal tract, the thyroidal involvement in this case is unusual.
D000328:Adult; D003937:Diagnosis, Differential; D004587:Electrophoresis, Agar Gel; D005260:Female; D006042:Goiter / Q000175:diagnosis* / Q000601:surgery; D006362:Heavy Chain Disease / Q000175:diagnosis*; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000302:isolation & purification; D007137:Immunoglobulin alpha-Chains; D010954:Plasmacytoma / Q000601:surgery*
D007147:Immunoglobulin Light Chains; D007137:Immunoglobulin alpha-Chains