Cimetidine-induced alterations in desipramine plasma concentrations.
Concurrent administration of cimetidine for 4 days to eight patients taking maintenance doses of desipramine led to significant elevations of desipramine (P less than 0.001) and its hydroxylated metabolite 2-hydroxydesipramine (P less than 0.001). The mean increase in desipramine plasma levels was 51% and that for 2-hydroxydesipramine was 46%. The present results suggest that tricyclic antidepressant plasma level monitoring might be indicated for certain patients taking concurrent cimetidine and desipramine.
D000328:Adult; D001711:Biotransformation; D002927:Cimetidine / Q000494:pharmacology*; D003891:Desipramine / Q000031:analogs & derivatives / Q000097:blood* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged
D002927:Cimetidine; D003891:Desipramine; C028653:2-hydroxydesipramine