Chrysiasis following gold therapy for rheumatoid arthritis: ultrastructural analysis with x-ray energy spectroscopy.
Chrysiasis is a rare, permanent, pigmentation of the skin caused by the parenteral administration of gold preparations followed by subsequent exposure to ultraviolet light. We report a case of chrysiasis following gold therapy for rheumatoid arthritis, wherein ultrastructural analysis combined with x-ray energy spectroscopy afforded precise identification and localization of the gold pigment in skin biopsy specimens.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001706:Biopsy; D005260:Female; D006046:Gold / Q000032:analysis; D006052:Gold Sodium Thiomalate / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D012867:Skin / Q000032:analysis / Q000648:ultrastructure; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology; D013057:Spectrum Analysis; D014965:X-Rays
D006052:Gold Sodium Thiomalate; D006046:Gold