[Role of the sympathetic nervous system in regulating the production of erythrocytic chalone].
In rats, administration of the diphtheric toxin and propranolol after acute hemorrhage decreased production of the erythrocyte chalone. In vitro, adrenalin or ephedrine addition to erythrocytes increased excretion of the erythrocyte chalone. There is a direct correlation between production of chalone and depression of the bone marrow mitotic activity. The mechanism of the chalone release under the effect of the sympathetic transmitters, is discussed.
D000313:Adrenal Medulla / Q000502:physiology*; D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D004167:Diphtheria Toxin / Q000494:pharmacology; D004809:Ephedrine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D004912:Erythrocytes / Q000378:metabolism*; D006131:Growth Inhibitors / Q000096:biosynthesis*; D006470:Hemorrhage / Q000097:blood / Q000473:pathology; D066298:In Vitro Techniques; D008938:Mitosis; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013564:Sympathetic Nervous System / Q000502:physiology*
D004167:Diphtheria Toxin; D006131:Growth Inhibitors; D011433:Propranolol; D004809:Ephedrine; D004837:Epinephrine
Rol' simpaticheskoĭ nervnoĭ sistemy v reguliatsii produktsii éritrotsitarnogo keĭlona.