[Changes in LH, FSH, PRL and estradiol after perfusion with naloxone in normal and amenorrheic women].
Naloxone is antagonistic to endogenous opioids. Giving it shows that these opioids act as controlling mechanisms in the secretion of LH and FSH by the hypothalamic, pituitary system and probably of Gn-RH by the hypothalamus. Endogenous opioids and particularly beta endorphin, which is itself under the control of oestradiol, play an inhibitory role on the secretion of Gn-RH and alter the pulsatile mode of Gn-RH secretion. We could not demonstrate PRL action which has been described by other authors.
D000568:Amenorrhea / Q000097:blood*; D004958:Estradiol / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007275:Injections, Intravenous; D007986:Luteinizing Hormone / Q000097:blood*; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood*; D013997:Time Factors
D009270:Naloxone; D004958:Estradiol; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Variations de L.H., F.S.H., P.R.L. et de l'estradiol après perfusion de naloxone chez les femmes normales et aménorrhéiques.