title: Stimulation of aflatoxin B1 and T-2 toxin production by sorbic acid.
abstract: Aspergillus flavus grown on yeast extract-sucrose medium produced higher amounts of aflatoxin B1 in the presence of 0.025% sorbic acid than without this chemical with a maximum at 17 days of incubation. Addition of 0.05 to 0.0125% sorbic acid stimulated T-2 toxin production of Fusarium acuminatum cultures grown on maize meal. The highest amounts of the mycotoxin were detected in 14-day-old cultures containing 0.025% sorbic acid. It is assumed that certain amounts of sorbic acid near the minimal inhibitory concentration reduce the activity of the tricarboxylic acid cycle; this may lead to an accumulation of acetyl coenzyme A, which is an essential intermediate in the biosynthesis of aflatoxin B1 and T-2 toxin.
mesh_terms: D016604:Aflatoxin B1; D000348:Aflatoxins / Q000096:biosynthesis*; D001231:Aspergillus flavus / Q000187:drug effects* / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005670:Fusarium / Q000187:drug effects* / Q000378:metabolism; D012717:Sesquiterpenes / Q000096:biosynthesis*; D013011:Sorbic Acid / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013605:T-2 Toxin / Q000096:biosynthesis*
chemical_list: D000348:Aflatoxins; D005231:Fatty Acids, Unsaturated; D012717:Sesquiterpenes; D016604:Aflatoxin B1; D013605:T-2 Toxin; D013011:Sorbic Acid