Effects of cytotoxic drugs on proliferative vitreoretinopathy in the rabbit cell injection model.
The effects of adriamycin, 5-fluorouracil, methotrexate, triamcinolone and Viroptic on an experimental model of proliferative vitreoretinopathy (PVR) produced by the injection of homologous dermal fibroblasts into the rabbit vitreous were studied. Adriamycin and fluorouracil inhibited fibroblast proliferation and prevented the formation of membranes as well as did triamcinolone, whereas methotrexate and Viroptic had no beneficial effect in this model of PVR.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000627:therapeutic use; D005128:Eye Diseases / Q000188:drug therapy; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D005472:Fluorouracil / Q000627:therapeutic use; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D011817:Rabbits; D012163:Retinal Detachment / Q000188:drug therapy*; D012164:Retinal Diseases / Q000188:drug therapy*; D014221:Triamcinolone / Q000627:therapeutic use; D014271:Trifluridine / Q000627:therapeutic use; D014822:Vitreous Body / Q000187:drug effects
D000970:Antineoplastic Agents; D014221:Triamcinolone; D004317:Doxorubicin; D014271:Trifluridine; D005472:Fluorouracil; D008727:Methotrexate