title: Ultrastructural and histochemical studies of granular-cell ameloblastoma.
abstract: Four cases of granular-cell ameloblastoma were studied by light and electron microscopy, histochemistry and electron enzyme histochemistry. Microscopically, granular cells commonly occurred in a follicular pattern, but, in one case, they were in a plexiform pattern. The high activity of acid phosphatase and electron microscopic features revealed that the cytoplasmic granularity was ascribed to the high content of lysosomes. It was speculated that granular-cell ameloblastoma occurs due to the altered dysfunction of tumor cells, and the age factor is related to the pathogenesis of this tumor.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000368:Aged; D000469:Alkaline Phosphatase / Q000378:metabolism; D000564:Ameloblastoma / Q000201:enzymology / Q000648:ultrastructure*; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D008297:Male; D008339:Mandibular Neoplasms / Q000201:enzymology / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008875:Middle Aged; D009284:Naphthols / Q000378:metabolism
chemical_list: D009284:Naphthols; C027876:alpha-naphthyl acetate; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D005966:Glucuronidase