Anti-Rh32 causing severe hemolytic disease of the newborn.
A case of severe hemolytic disease of the newborn due to anti-Rh32 (R = N) is described. The infant recovered without any evidence of neurologic defects, following one exchange transfusion and phototherapy. Using commercial antisera, very weak reactions with anti-Rh2(C) and apparently normal reactions with anti-Rh5(e) were found in the family members carrying the R = N gene complex. However titrations with individual antisera revealed a weakened expression of the Rh5(e) antigen, albeit to a lesser extent than the Rh2(C). It is felt that the serologic findings are due to the fact that the R = N haplotype was paired with an Rh gene carrying normal amounts of Rh4(c) and Rh5(e) antigens. In addition, the maternal anti-Rh32 appears to be pure.
D000293:Adolescent; D001803:Blood Transfusion; D004899:Erythroblastosis, Fetal / Q000209:etiology* / Q000276:immunology / Q000628:therapy; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D010789:Phototherapy; D011247:Pregnancy; D012203:Rh Isoimmunization / Q000150:complications*