title: Aromatic radiofluorination with [18F]fluorine gas: 6-[18F]fluoro-L-dopa.
abstract: A new synthesis is described for the routine production of 3,4-dihydroxy-6-[18F]fluoro-phenyl-L-alanine (6-[18F]fluoro-L-dopa). The reaction between [18F]fluorine gas and 3,4-dihydroxyphenyl-L-alanine (L-dopa) in liquid hydrogen fluoride gave 2-, 5-, and 6-[18F]fluoro-L-dopa. 6-[18F]Fluoro-L-dopa was isolated by reverse-phase high-pressure liquid chromatography. From 100 mCi [18F]F2, the method produces 3 mCi of 6-[18F]fluoro-L-dopa at the end of synthesis.
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D005461:Fluorine; D007553:Isotope Labeling; D007980:Levodopa / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D011868:Radioisotopes
chemical_list: D011868:Radioisotopes; D005461:Fluorine; C043437:fluorodopa F 18; D007980:Levodopa; D004295:Dihydroxyphenylalanine