title: Effects on gastric acid secretion of a steroidal alkaloid, epipachysamine-A, extracted from Pachysandra terminalis Sieb. et Zucc.
abstract: Effect of a steroidal alkaloid, epipachysamine-A, extracted from Pachysandra terminalis Sieb. et Zucc. on gastric acid secretion was studied in rats. Epipachysamine-A prevented 2-deoxy-D-glucose- or thyrotropin-releasing hormone-stimulated gastric acid secretion in anesthetized rats. However, the compound did not influence bethanechol- or electrical vagal stimulation-induced gastric acid secretion. These results suggest that the effect of epipachysamine-A is due to the influence on the central nervous regulatory mechanism in the gastric acid secretion.
mesh_terms: D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001626:Bethanechol Compounds / Q000494:pharmacology; D001921:Brain / Q000187:drug effects; D003847:Deoxyglucose / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism*; D007564:Japan; D008297:Male; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D014630:Vagus Nerve / Q000502:physiology
chemical_list: D000470:Alkaloids; D001626:Bethanechol Compounds; C042147:epipachysamine A; D013973:Thyrotropin-Releasing Hormone; D003847:Deoxyglucose