Enhancement by intracerebroventricular thyrotropin-releasing hormone of indomethacin-induced gastric lesions in the rat.
Effects of the intracerebroventricular thyrotropin-releasing hormone (TRH) on gastric mucosa were studied in rats. TRH (3 and 10 micrograms rat-1 i.c.v.) produced slight gastric lesions and also aggravated indomethacin-, aspirin- or 5-hydroxytryptamine (5-HT)-induced gastric lesions, while restraint and cold stress-induced lesions were not influenced by TRH. Bethanechol used at a dose sufficient to produce acid secretion did not influence the gastric mucosa in intact or indomethacin-treated rats. Enhancement of indomethacin-induced gastric lesions by TRH was not inhibited to any significant degree by atropine 0.1 mg kg-1 s.c., which prevented TRH-induced gastric acid secretion, but tended to be inhibited by phentolamine, 2.5 mg kg-1 i.p. It is concluded that the enhancement by TRH of indomethacin-induced gastric lesions is due to a combination of the central and peripheral actions of the ulcerogenic agents.
D000818:Animals; D004347:Drug Interactions; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D007213:Indomethacin / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*
D013973:Thyrotropin-Releasing Hormone; D007213:Indomethacin