Inhibition of platelet ADP and serotonin release by carbon monoxide and in cigarette smokers.
The release of 14C-serotonin by ADP, epinephrine and arachidonic acid and the release of ADP by kaolin were measured in normal platelets in the presence and absence of carbon monoxide and in smokers' platelets. It is shown that carbon monoxide inhibits significantly the platelet release reaction. This function is also decreased in platelets obtained from heavy cigarette smokers.
D000244:Adenosine Diphosphate / Q000097:blood* / Q000494:pharmacology; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000097:blood; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002248:Carbon Monoxide / Q000494:pharmacology*; D004837:Epinephrine / Q000494:pharmacology; D006801:Humans; D010947:Plants, Toxic; D010974:Platelet Aggregation / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism*; D012907:Smoking; D014026:Nicotiana
D001095:Arachidonic Acids; D016718:Arachidonic Acid; D012701:Serotonin; D000244:Adenosine Diphosphate; D002248:Carbon Monoxide; D004837:Epinephrine