5-hydroxytryptophan and pyridoxine. Their effects in young children with Down's syndrome.
In a double-blind study, 89 children with Down's syndrome were given 5-hydroxytryptophan or pyridoxine hydrochloride in the first three years of life. The analysis of 5-hydroxyindole blood levels revealed that 5-hydroxytryptophan, pyridoxine, and the combination of 5-hydroxytryptophan and pyridoxine raised blood levels of 5-hydroxyindole equally well in 40% of the children. The assessment of muscle-tone ratings showed no significant difference among the study groups once children with moderate and severe congenital heart disease were excluded. Detailed studies of cognitive-adaptive function of children in the various groups found a significant difference ont the Vineland Social Maturity Scale at ages 6, 12, 18, and 36 months; yet the source of significance was a negative interaction affecting children whose parents were able to comply with furnished guidance; these children showed consistently higher levels of accomplishment.
D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004314:Down Syndrome / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007211:Indoles / Q000097:blood; D007223:Infant; D007231:Infant, Newborn; D007360:Intelligence / Q000187:drug effects; D007361:Intelligence Tests; D007804:Language Development; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D011581:Psychological Tests; D011736:Pyridoxine / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D012701:Serotonin / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D012919:Social Behavior
D007211:Indoles; C026785:5-hydroxyindole; D012701:Serotonin; D011736:Pyridoxine