Cerebral blood flow, oxygen, carbon dioxide tensions, and blood bicarbonate in controlling drive and timing in patients with chronic obstructive pulmonary diseases.
In patients with chronic obstructive pulmonary disease, respiratory drive as estimated from occlusion pressures (PO.1 and PO.1/PCO2, cm H2O/mm Hg) and respiratory timing (T1, T1/TTOT) were predicted accurately by multiple regression analysis from the respiratory parameters PO2, PCO2, and blood HCO3 in conjunction with estimates of cerebral blood flow. We used four linear models to obtain essentially the same multiple correlation coefficient, indicating that these independent variables are all important factors in controlling both the drive and timing of respiration.
D000328:Adult; D000368:Aged; D001639:Bicarbonates / Q000097:blood; D001784:Blood Gas Analysis; D002245:Carbon Dioxide / Q000502:physiology; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008173:Lung Diseases, Obstructive / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000502:physiology; D012044:Regression Analysis; D012119:Respiration; D012129:Respiratory Function Tests; D013997:Time Factors
D001639:Bicarbonates; D002245:Carbon Dioxide; D010100:Oxygen