Restriction enzyme analysis of the apolipoprotein A-I gene in fish eye disease and Tangier disease.
Restriction enzyme analysis of the apolipoprotein A-I (apo A-I) gene was performed in two patients with fish eye disease and one with Tangier disease. Despite the marked deficiency of high density lipoprotein and concomitantly of apo A-I in these two conditions, no evidence was found for major deletions or insertions in the apo A-I gene.
D000368:Aged; D016632:Apolipoprotein A-I; D001053:Apolipoproteins / Q000097:blood* / Q000235:genetics; D003318:Corneal Opacity / Q000097:blood* / Q000235:genetics; D004247:DNA / Q000032:analysis; D004587:Electrophoresis, Agar Gel; D005260:Female; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood* / Q000235:genetics; D007009:Hypolipoproteinemias / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013577:Syndrome; D013631:Tangier Disease / Q000097:blood* / Q000235:genetics
D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D004247:DNA