title: Post danazol amenorrhoea.
abstract: Four women out of 242 experienced amenorrhoea in excess of 6 months duration following danazol treatment. Two of these exhibited an unusual monotropic rise of FSH into the post menopausal range for 4-5 months following the end of therapy. This was associated with an excessive response to GnRH injection. The mechanism of this temporary FSH rise is unknown. A causal association of the amenorrhoea and monotropic FSH rise following danazol therapy is unproven but seems likely.
mesh_terms: D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000097:blood / Q000139:chemically induced*; D003613:Danazol / Q000009:adverse effects* / Q000627:therapeutic use; D004715:Endometriosis / Q000188:drug therapy; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D011245:Pregnadienes / Q000009:adverse effects*; D013997:Time Factors; D014594:Uterine Neoplasms / Q000188:drug therapy
chemical_list: D011245:Pregnadienes; D005640:Follicle Stimulating Hormone; D003613:Danazol