The effect of DMSO treatment on the performance of [99mTc]HEDP.
The effect of treating a commercial skeletal imaging kit containing hydroxyethylidene diphosphonate (HEDP) with dimethyl sulfoxide (DMSO) prior to labeling with sodium pertechnetate, 99mTc[TcO4-], was investigated. Statistically, significant differences (P less than 0.05) in soft tissue retention (blood and muscle) were seen in rats after injection with the DMSO-treated HEDP compared to the nontreated HEDP. Based on i.r. and HPLC data, it appears that DMSO acts as an extractant for certain Sn2+-HEDP complexes which contribute to greater soft-tissue retention.
D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D012968:Etidronic Acid; D005260:Female; D009132:Muscles / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium; D014018:Tissue Distribution
D015609:Organotechnetium Compounds; C019561:technetium Tc 99m etidronate; D013667:Technetium; D012968:Etidronic Acid; D004121:Dimethyl Sulfoxide