Organosilicone induced malformation of rat sperms, a histochemical study.
The effects of an organosilicon compound SOC, a derivative of 1,3-dioxa-2-sila-cyclopentane, on rat spermiogenesis were studied with the help of histochemical and enzyme histochemical methods. The rats were injected with SOC i.p. daily for 3 weeks (dosage: 25 mg SOC/kg body weight). Two changes were observed: a) formation of a distinct vacuole within the acrosomal cap of spermatids b) the splitting of the tails of mature sperms.
D000177:Acrosome / Q000187:drug effects; D000818:Animals; D003517:Cyclopentanes / Q000633:toxicity*; D008297:Male; D017646:Organosilicon Compounds; D051381:Rats; D011919:Rats, Inbred Strains; D012825:Silicon / Q000633:toxicity*; D013082:Sperm Tail / Q000187:drug effects; D013087:Spermatids / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*; D014617:Vacuoles / Q000187:drug effects
D003517:Cyclopentanes; D017646:Organosilicon Compounds; C039270:2,2-dimethyl-4-(chloromethyl)-1,3-dioxa-2-silacyclopentane; D012825:Silicon