The failure of ventricular sodium to control sodium appetite in the rat.
Dilution of CSF sodium by infusion of hyperosmotic mannitol into the cerebral ventricles of the rat does not evoke a salt appetite, nor does the addition of sodium to the CSF of the rat suppress the preexisting salt appetites produced by the hormones of sodium conservation or by adrenalectomy. CSF sodium concentration does not control sodium appetite in the rat. The proposal that it does so in sheep should not be generalized to other species without caution.
D000311:Adrenal Glands / Q000502:physiology; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001066:Appetite / Q000502:physiology*; D003216:Conditioning, Operant / Q000502:physiology; D003900:Desoxycorticosterone / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012462:Saline Solution, Hypertonic; D012646:Self Administration; D012964:Sodium / Q000134:cerebrospinal fluid*; D012965:Sodium Chloride / Q000008:administration & dosage*; D014882:Water-Electrolyte Balance / Q000187:drug effects
D012462:Saline Solution, Hypertonic; D000804:Angiotensin II; D008353:Mannitol; D003900:Desoxycorticosterone; D012965:Sodium Chloride; D012964:Sodium