Evaluation of visual function in healthy subjects after administration of Ro 15-1788.
Ro 15-1788 is a specific benzodiazepine antagonist, which has also been shown to have some agonist properties. Since benzodiazepine receptors are involved in the physiological mechanisms of vision, a possible intrinsic effect of Ro15-1788 was sought in 6 healthy volunteers by study of psychophysical flicker thresholds, including critical fusion frequency and low frequency modulation threshold, and pattern reversal visual evoked response, using double blind cross-over methodology. In each session 2 tablets of Ro 15-1788 30 mg were administered. Using a two factorial univariate analysis of variance, no change was detected in any of the parameters studied.
D000328:Adult; D001570:Benzodiazepinones / Q000494:pharmacology*; D003292:Convulsants / Q000494:pharmacology*; D004311:Double-Blind Method; D005074:Evoked Potentials, Visual / Q000187:drug effects; D005260:Female; D005425:Flicker Fusion / Q000187:drug effects; D005442:Flumazenil; D006801:Humans; D008297:Male; D010775:Photic Stimulation; D014785:Vision, Ocular / Q000187:drug effects*
D001570:Benzodiazepinones; D003292:Convulsants; D005442:Flumazenil