Participation of suppressor T cells in the immunosuppressive activity of a heteroantiserum to human Ia-like antigens (p23,30).
We studied the effects of an antiserum to human Ia-like antigens (p23,30) upon the polyclonal activation of normal B cells (cultured with various combination of irradiated and unirradiated T cells) to become immunoglobulin-secreting cells after stimulation with pokeweed mitogen in vitro. We found that the antiserum suppressed immunoglobulin production. The inhibitory effect did not appear to result from a simple interaction at the B-cell/monocyte level alone. Rather, the inhibitory effect required the presence of a radiosensitive subset of autologous suppressor T cells.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D001789:Blood Group Antigens; D002478:Cells, Cultured; D006801:Humans; D007048:I Blood-Group System; D007106:Immune Sera; D007165:Immunosuppression Therapy; D008934:Mitogens; D011817:Rabbits / Q000276:immunology; D050378:T-Lymphocytes, Regulatory
D001789:Blood Group Antigens; D007048:I Blood-Group System; D007106:Immune Sera; D008934:Mitogens