[Effects of 5 alpha-androstane-3 beta, 17 beta-diol on release of luteinizing hormone (LH) from 36-38 day old male and female rat anterior pituitaries perifused with constant amounts of gonadotrophin releasing hormone (Gn-GH)].
In vitro (perifusion of rat pituitaries) the 5 alpha-androstane-3 beta, 17 beta diol (3 beta diol) exerts inhibitory effects on Gn-RH stimulated LH secretion. The 3 beta diol is more potent at high dose (1 micrograms/ml) than low dose (100 ng/ml) and in the male rat than in the female rat.
D015113:Androstane-3,17-diol / Q000494:pharmacology*; D000732:Androstanols / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D066298:In Vitro Techniques; D007700:Kinetics; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D012737:Sex Factors
D000732:Androstanols; D015113:Androstane-3,17-diol; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone
Etude, par la technique de périfusion d'hypophyse antérieure, de l'influence du 5 alpha-androstane-3 beta, 17 beta diol sur la libération, stimulée en continu par la gonadolibérine (Gn-RH), de l'hormone lutéinisante (LH) chez le rat mâle et le rat femelle, âgés de 36-38 jours.