title: [Principles of the interaction of curare-like agents with skeletal muscle cholinoreceptors].
abstract: The principles of interaction of curare-like agents with acetylcholine receptors of skeletal muscles are discussed. The possible types of interatomic bonds of substances with receptors are exemplified by different chemical compounds which possess the neuromuscular blocking action. Prior attention is given to the role of hydrophobic interactions in the activity and mechanism of action of curare-like agents.
mesh_terms: D001665:Binding Sites / Q000187:drug effects; D004347:Drug Interactions; D004594:Electrophysiology; D006859:Hydrogen / Q000378:metabolism; D007477:Ions; D009132:Muscles / Q000187:drug effects*; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology; D003473:Neuromuscular Nondepolarizing Agents / Q000494:pharmacology*; D011950:Receptors, Cholinergic / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D007477:Ions; D009466:Neuromuscular Blocking Agents; D003473:Neuromuscular Nondepolarizing Agents; D011950:Receptors, Cholinergic; D006859:Hydrogen
vernacular_title: O printsipakh vzaimodeoĭstviia kurarepodobnykh sredstv s kholinoretseptorami skeletnykh myshts.