An acquired inhibitor of factor XIII with a qualitative abnormality of fibrin cross-linking.
A patient with an acquired inhibitor to factor XIII is reported. The patient's plasma produced a profound inhibition of factor XIII activity in normal plasma measured by a dansylcadaverine casein assay and stimulated a very abnormal pattern of fibrin cross-linking, not normally seen with factor XIII. Partial characterisation of the inhibitor suggests that it is heat stable and not an immunoglobulin.
D000085:Acetates; D001778:Blood Coagulation Disorders / Q000097:blood*; D001780:Blood Coagulation Tests; D004591:Electrophoresis, Polyacrylamide Gel; D005176:Factor XIII / Q000032:analysis / Q000037:antagonists & inhibitors*; D005260:Female; D005337:Fibrin / Q000378:metabolism*; D006474:Hemorrhagic Disorders / Q000097:blood; D006801:Humans; D014508:Urea
D000085:Acetates; C006972:chloroacetic acid; D014508:Urea; D005337:Fibrin; D005176:Factor XIII