Liposome accumulation in chronic ischaemia is dependent on tissue necrosis.
Liposomes accumulate is ischaemic rat intestine 24 h after mesenteric occlusion. The accumulation of liposomal components is shown to depend on necrotic or allied alterations in cell integrity/function associated with chronic ischaemia. Moreover, not all liposomal components accumulate at sites of infarction. It is concluded therefore that liposomes are likely to be of little value in the diagnosis and management of ischaemic disorders.
D000818:Animals; D012968:Etidronic Acid / Q000008:administration & dosage; D006854:Hydrocortisone / Q000008:administration & dosage; D007422:Intestines / Q000098:blood supply* / Q000473:pathology; D007511:Ischemia / Q000378:metabolism*; D008081:Liposomes / Q000008:administration & dosage; D008297:Male; D009336:Necrosis; D014677:Pharmaceutical Vehicles; D051381:Rats; D013752:Tetracycline / Q000008:administration & dosage; D013997:Time Factors
D008081:Liposomes; D014677:Pharmaceutical Vehicles; D013752:Tetracycline; D012968:Etidronic Acid; D006854:Hydrocortisone