[Systemic light-chain disease as a complication of plasmacytoma].
An asymptomatic multiple myeloma of the kappa-light chain type was found in a patient with nephrotic syndrome and renal insufficiency. Light microscopy showed nodular glomerulosclerosis of the kidney similar to diabetic glomerulosclerosis. Diabetes mellitus could not be demonstrated. kappa-Light chain deposits could be shown by immunohistology in the mesangium and the glomerular and tubular basal membrane. In addition, massive kappa-light chain deposits in the sinusoidal walls of the liver and at the dermoepidermal junction of the skin and in the corium were found.
D000971:Antineoplastic Combined Chemotherapy Protocols; D001536:Bence Jones Protein / Q000652:urine; D001854:Bone Marrow Cells; D002330:Carmustine / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications*; D006977:Hypertension, Renal / Q000150:complications; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000150:complications; D010950:Plasma Cells; D010954:Plasmacytoma / Q000150:complications* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D014750:Vincristine / Q000627:therapeutic use
D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D014750:Vincristine; D003520:Cyclophosphamide; D001536:Bence Jones Protein; D008558:Melphalan; D002330:Carmustine; D011241:Prednisone
Systemische Leichtkettenerkrankung als Komplikation des Plasmozytoms.