Changes in serum LH and FSH following preovulatory administration of ethanol in rats.
The effect of different single doses of ethanol (1.0, 2.0 and 4.0 g/kg) on serum LH and FSH has been studied in rats treated during preovulatory periods (18th h of diestrous). High doses of ethanol (2.0 and 4.0 g/kg) decreased serum LH levels at the 18th h of proestrous, 24 h after ethanol administration, inhibiting the preovulatory LH surge. No changes were observed in FSH levels. These effects could be mediated through the inhibition of the hypothalamic releasing factors.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood*; D010060:Ovulation / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone