Reversal of leukotriene D4 hypotension by thyrotropin-releasing hormone.
Thyrotropin-releasing hormone (TRH) reversed the hypotension produced by leukotriene D4 (LTD4) (5 micrograms/kg, i.v.) in conscious guinea pigs in a dose-dependent fashion at intravenous doses between 0.2 and 2.0 mg/kg. LTD4 hypotension was also reversed by the synthetic TRH analog MK771 (0.2 or 2 mg/kg, i.v.), suggesting a possible receptor-mediated mechanism. Since LTD4 has been implicated as a mediator of anaphylaxis, these results provide a basis for further evaluation of TRH and its analogs in the treatment of anaphylactic shock.
D000818:Animals; D006168:Guinea Pigs; D007022:Hypotension / Q000139:chemically induced*; D008297:Male; D013189:SRS-A / Q000037:antagonists & inhibitors*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D013189:SRS-A; D013973:Thyrotropin-Releasing Hormone