Behavioural effects of pentylenetetrazole reversed by chlordiazepoxide and enhanced by RO 15-1788.
The effects of low doses of pentylenetetrazole (PTZ) on exploratory behaviour and locomotor activity in the rat, were measured in the holeboard apparatus. PTZ (30 mg/kg) significantly reduced exploratory head-dipping, an effect that was significantly reversed by chlordiazepoxide (5 mg/kg) and enhanced by RO 15-1788 (20 mg/kg). RO 15-1788 (20 mg/kg) also significantly enhanced the reduction in locomotor activity produced by PTZ (30 mg/kg); although this reduction was not reversed by chlordiazepoxide (5 mg/kg) the reduction in locomotor activity with the drug combination was no greater than that with either drug alone. The results are discussed with respect to a coupling between the benzodiazepine receptors and the site at which PTZ acts.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001570:Benzodiazepinones / Q000494:pharmacology*; D002707:Chlordiazepoxide / Q000494:pharmacology*; D005442:Flumazenil; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D001570:Benzodiazepinones; D005442:Flumazenil; D002707:Chlordiazepoxide; D010433:Pentylenetetrazole