title: The management of musculoskeletal problems in hemophilia. Part I. Principles of medical management of hemophilia.
abstract: Musculoskeletal bleeding in general and arthropathy in particular are the central problems among many in the two major forms of hemophilia: classic hemophilia, caused by factor VIII deficiency, and Christmas disease, caused by factor IX deficiency. Currently available replacement therapy, if properly used in a multidisciplinary setting, should provide significant benefit to hemophilic patients despite its cost and occasional complications.
mesh_terms: D000743:Anemia, Hemolytic / Q000209:etiology; D005164:Factor IX / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D005169:Factor VIII / Q000037:antagonists & inhibitors / Q000627:therapeutic use; D005340:Fibrinogen / Q000627:therapeutic use; D006395:Hemarthrosis / Q000209:etiology; D006467:Hemophilia A / Q000097:blood / Q000150:complications / Q000628:therapy*; D002836:Hemophilia B / Q000097:blood / Q000150:complications / Q000628:therapy; D006487:Hemostasis; D006509:Hepatitis B / Q000635:transmission; D006801:Humans; D065227:Transfusion Reaction
chemical_list: C026912:cryoprecipitate coagulum; D005169:Factor VIII; D005164:Factor IX; D005340:Fibrinogen