The cyclo-oxygenase and lipoxygenase pathways in human oral cancer tissue.
This paper reports on the synthesis of prostaglandins in oral squamous epithelial carcinomas. Using radio-thin-layer chromatography, we observed the conversion of 14C-labelled arachidonic acid into the prostaglandins PGE2, PGF2 alpha, PGI2 and PGD2. We also observed an approximately equal production of hydroxy fatty acids. The role of the above-mentioned substances in the growth of malignant tumours and the process of metastasis is discussed.
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000201:enzymology / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D015237:Dinoprost; D015232:Dinoprostone; D011464:Epoprostenol / Q000096:biosynthesis; D005227:Fatty Acids / Q000096:biosynthesis; D005260:Female; D005887:Gingival Neoplasms / Q000378:metabolism*; D006801:Humans; D008084:Lipoxygenase / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D011453:Prostaglandins / Q000096:biosynthesis*; D011458:Prostaglandins E / Q000378:metabolism; D011460:Prostaglandins F / Q000378:metabolism; D014062:Tongue Neoplasms / Q000201:enzymology / Q000378:metabolism*
D005227:Fatty Acids; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D015237:Dinoprost; D011464:Epoprostenol; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases; D015232:Dinoprostone