title: Early prediction of outcome after severe head injury in children.
abstract: Forty children with severe head injury were studies retrospectively. All were admitted to the medical center within 6 hours after injury. Seventeen had Glasgow Coma Scales of 3 to 4 and 23 scales of 5 to 7. Computerised tomography (CT) findings and coagulation abnormalities in the first 12 and intracranial pressure (ICP) in the first 24 hours after injury were examined in relation to the final result. Compressed basal cisterns in CT, presence of moderate to severe consumption coagulopathy (CC) and moderate to severe intracranial hypertension (ICP greater than 20 mmHg) all correlated significantly with fatal outcome. In contrast, survivors usually had patent basal cisterns on CT, normal coagulation data or only moderate CC and slight to rarely moderate intracranial hypertension. It is concluded that by using the proposed criteria, early assessment of severity and prediction of outcome after severe paediatric head injury is possible. In contrast to the Glasgow Coma Scale these criteria are applicable and retain predictive power also in children who receive early and intensive ICP-lowering therapy.
mesh_terms: D000293:Adolescent; D001780:Blood Coagulation Tests; D001926:Brain Death; D001930:Brain Injuries / Q000175:diagnosis* / Q000188:drug therapy / Q000401:mortality; D002648:Child; D002675:Child, Preschool; D003128:Coma / Q000209:etiology; D003907:Dexamethasone / Q000627:therapeutic use; D004211:Disseminated Intravascular Coagulation / Q000175:diagnosis; D004359:Drug Therapy, Combination; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007427:Intracranial Pressure / Q000187:drug effects; D008297:Male; D008353:Mannitol / Q000627:therapeutic use; D010634:Phenobarbital / Q000627:therapeutic use; D011379:Prognosis; D013874:Thiopental / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed
chemical_list: D008353:Mannitol; D005665:Furosemide; D003907:Dexamethasone; D013874:Thiopental; D010634:Phenobarbital