Malnutrition and oxygen at high pressure: influence on collagen synthesis in lung and heart of the newborn rat.
Rat dams were divided into a malnourished group fed 6% protein and a control group fed 25% protein. Newborns were selected from the two groups for injection with 14C-proline. Half of those injected were exposed to oxygen averaging 60 psig. Malnutrition impaired collagen synthesis in the lung as early as day 10 and in the heart at day 5. At day 20 and 30, pups from malnourished dams showed less severe convulsion than did the controls. Malnourished group displayed less adverse effect on lung and heart relative to body weight than did controls. Lung and heart collagen content in the malnourished group at days 15 and 10, respectively, were less than the controls. Between day 5 and day 20, OHP does not affect the metabolism of the lung and heart connective tissues, but it does by day 30. Malnutrition affects collagen metabolism of the heart earlier than it does the lung.
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000378:metabolism*; D003094:Collagen / Q000096:biosynthesis*; D006909:Hydroxyproline / Q000378:metabolism; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D008168:Lung / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D009929:Organ Size; D011502:Protein-Energy Malnutrition / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology
D003094:Collagen; D006909:Hydroxyproline