Toxicity of antineoplastic drug combinations in vitrectomy infusion fluid.
We evaluated a combination of various antineoplastic drugs used in vitrectomy infusion fluid for toxicity. A combination of 250 micrograms/ml of 5-fluorouracil with each of the following agents, 8.0 micrograms/ml of thiotepa or 40 micrograms/ml of etoposide, or 0.1 micrograms/ml doxorubicin, or 0.1 microgram/ml vincristine was tolerated well in the rabbit eyes.
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000633:toxicity*; D004317:Doxorubicin / Q000633:toxicity; D005047:Etoposide / Q000633:toxicity; D005472:Fluorouracil / Q000633:toxicity; D009883:Ophthalmic Solutions / Q000633:toxicity*; D011817:Rabbits; D013852:Thiotepa / Q000633:toxicity; D014750:Vincristine / Q000633:toxicity; D014821:Vitrectomy
D009883:Ophthalmic Solutions; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D013852:Thiotepa; D005472:Fluorouracil