Induction of susceptibility to HgCl2 immune glomerulonephritis in the Lewis rat by immunocompetent cells from susceptible F1 hybrids.
Susceptibility to HgCl2-induced glomerulonephritis was transferred to resistant Lewis (LEW) rats, irradiated and reconstituted with (LEW X BN)F1 hybrid immunocompetent cells. This glomerulonephritis was similar to that observed in Brown-Norway (BN) rats with a first stage characterized by anti-glomerular basement membrane antibodies and a second stage with immune complex-type deposits in the glomerular tufts and in the small renal arteries.
D000818:Animals; D000906:Antibodies; D001402:B-Lymphocytes / Q000276:immunology*; D003037:Cobalt Radioisotopes; D005260:Female; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000139:chemically induced / Q000276:immunology*; D006238:Haploidy; D006824:Hybridization, Genetic; D007668:Kidney / Q000276:immunology; D008297:Male; D008627:Mercuric Chloride; D008628:Mercury; D011828:Radiation Chimera; D051381:Rats; D011914:Rats, Inbred BN / Q000235:genetics; D011917:Rats, Inbred Lew / Q000235:genetics / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000906:Antibodies; D003037:Cobalt Radioisotopes; D008627:Mercuric Chloride; D008628:Mercury