Amphetamine anorexia: the effect of radio-frequency lesions and 6-OHDA injections into dopaminergic nigro-striatal bundle in cats.
The effect of radio-frequency (RF) and 6-OHDA lesions of two levels of dopaminergic nigro-striatal bundle on amphetamine anorexia was investigated in 4 groups of cats. RF and 6-OHDA lesions of far-lateral hypothalamus produced significant facilitation of feeding after injection of amphetamine. RF and 6-OHDA destructions of substantia nigra were with slight or without (respectively) effect on amphetamine anorexia. The results suggest that nigrostriatal bundle is not essential for mechanisms mediating amphetamine anorexia.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D003342:Corpus Striatum; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D006892:Hydroxydopamines / Q000008:administration & dosage / Q000494:pharmacology*; D007033:Hypothalamus, Middle / Q000502:physiology; D007267:Injections; D008297:Male; D016627:Oxidopamine; D011846:Radio Waves; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D012737:Sex Factors; D013378:Substantia Nigra
D006892:Hydroxydopamines; D011954:Receptors, Dopamine; D016627:Oxidopamine; D000661:Amphetamine