[Antitumor effect of interferons].
Recent reports on the antitumor activity of interferon-gamma were reviewed and compared to a study on interferon-alpha beta. Secondly our results on the antitumor effects of murine IFN-gamma on Meth-A sarcoma in syngeneic BALB/c mice were described in detail. Topical injection of IFN-gamma to the tumor site, Winn neutralization test of IFN-gamma activated spleen cells and adoptive transfer of IFN-gamma activated cells to the tumor site all resulted in positive antitumor effects. Finally, data on clinical trials of natural and recombinant IFNs presented at the 13th International Congress of Chemotherapy were summarized and the development of future IFN research was discussed.
D000818:Animals; D005260:Female; D007370:Interferon Type I / Q000627:therapeutic use*; D007371:Interferon-gamma / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D012513:Sarcoma, Experimental / Q000276:immunology / Q000473:pathology / Q000628:therapy; D013154:Spleen / Q000276:immunology
D007370:Interferon Type I; D007371:Interferon-gamma