title: [Chromosome aberrations in F1 (NZBxNZW) mice--an experimental model of systemic lupus erythematosus].
abstract: Spontaneous and mitomycin-C-induced chromosomal aberration level was studied in bone marrow cells of mice F1 (NZBXNZW), an experimental model of systemic lupus erythematosus and in C57BL/6J mice. The chromosome instability level is found to correspond to the degree of the autoimmune process: F1 (NZBXNZW) mice with the highest titer of autoantibodies to DNA has higher chromosomal mutability.
mesh_terms: D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D002869:Chromosome Aberrations; D004195:Disease Models, Animal; D005260:Female; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB / Q000235:genetics*; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology
chemical_list: D008937:Mitomycins; D016685:Mitomycin
vernacular_title: Khromosomnye aberratsii u mysheĭ F1 (NZBxNZW)--éksperimental'noĭ modeli sistemnoĭ krasnoĭ volchanki.