[Incidence of chromosome aberrations in the bone marrow of monkeys and their progeny after exposure to aflatoxin B1].
A mutagenic effect of aflatoxin B1 (AFB1) was studied in somatic cells of primates. It is shown that AFB1 elevates the chromosome aberration frequency in bone marrow cells of two monkey species: Macaca mulatta and Papio hamadryas. Genome mutations were found in these experimental primates simultaneously with chromosome aberrations. The AFB1-induced chromosome aberrations were revealed at least during two years of the study. The fact of the chromosome aberration frequency increase was established in Macaca babies born from females who received AFB1 in pregnancy.
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000494:pharmacology*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000648:ultrastructure; D002869:Chromosome Aberrations; D004171:Diploidy; D005260:Female; D008253:Macaca mulatta; D008297:Male; D009153:Mutagens / Q000494:pharmacology*; D010215:Papio; D011123:Polyploidy; D013997:Time Factors
D000348:Aflatoxins; D009153:Mutagens; D016604:Aflatoxin B1
Chastota aberratsiĭ khromosom v kostnom mozge obez'ian i ikh potomstva posle vozdeĭstviia aflatoksinom B1.