Immunoserology of Pseudomonas aeruginosa infections in man. II. effect of natural and immune anti-LPS antibodies on pseudomonas colonization and infection.
In 39 acute patients of a respiratory unit a comparatively high Pseudomonas aeruginosa anti-lipopolysaccharide antibody level present on admission prevented colonization by the homologous pseudomonas serogroup. At lower natural antibody titres symptomless colonization occurred, and in patients with the lowest initial titres, later P. aeruginosa complications developed. A low antibody level also predisposed to pseudomonas infection in 9 chronic patients. When colonization occurred at high antibody titres, the presence of P. aeruginosa was only transient; however, the titre had no effect on the further duration of harbouring P. aeruginosa. Anti-LPS antibodies may play an important role not only in the outcome of pseudomonas infection, but also in other respects of pseudomonas-man interaction.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000032:analysis*; D003428:Cross Infection / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008070:Lipopolysaccharides / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011552:Pseudomonas Infections / Q000276:immunology* / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000145:classification / Q000254:growth & development; D012703:Serotyping
D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D008070:Lipopolysaccharides