Factors modulating the formation of DNA adduct by aflatoxin B1 in vitro.
Forty-two compounds belonging to various chemical groups have been tested for their ability to suppress formation of aflatoxin B1--DNA adduct mediated by microsome in vitro. While many of these compounds have either marginal or no modulating effect, some have been identified as effective inhibitors. The strong inhibition of DNA adduct formation by retinoids (retinol, retinal, retinoic acid and retinyl acetate), riboflavin, riboflavin 5'-phosphate, flavin adenine dinucleotide, Cu2+, 7,8-benzoflavone, disulfiram, butylated hydroxyanisole, butylated hydroxytoluene and phenothiazine suggests that these agents may have potential anticarcinogenic activity against aflatoxin B1.
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D004247:DNA / Q000378:metabolism*; D005486:Flavin Mononucleotide / Q000494:pharmacology; D005182:Flavin-Adenine Dinucleotide / Q000494:pharmacology; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism*; D051381:Rats; D012256:Riboflavin / Q000494:pharmacology; D014801:Vitamin A / Q000494:pharmacology
D000348:Aflatoxins; D000975:Antioxidants; D014801:Vitamin A; D005182:Flavin-Adenine Dinucleotide; D005486:Flavin Mononucleotide; D004247:DNA; D016604:Aflatoxin B1; D012256:Riboflavin