title: The effect of aging on the positive chronotropic response to amitriptyline.
abstract: Amitriptyline (AT) increases sinus heart rate (SHR) due to inhibition of the reuptake of norepinephrine in combination with an antimuscarinic blockade of cardiac vagal inhibition. After 150 mg/day AT for 28 days, the change in SHR was negatively correlated with age in 42 depressed patients who were 18-85 years of age. This finding is consistent with observations that the tachycardic response to antimuscarinics and catecholamines decreases with aging.
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging; D000639:Amitriptyline / Q000494:pharmacology*; D003866:Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013268:Stimulation, Chemical
chemical_list: D000639:Amitriptyline