title: [Keratosis palmaris et plantaris areata Siemens. Therapeutic experiments with aromatic retinoid Ro 10-9359].
abstract: A family is presented with keratosis palmoplantaris areata Siemens in four generations. The hyperkeratotic plaques did not responds satisfactorily to treatment with aromatic retinoid Ro 10-9359. Therapy had to be discontinued because of side-effects. Proliferation-retention hyperkeratosis without epidermolytic features may not respond properly to aromatic retinoid treatment.
mesh_terms: D000328:Adult; D005050:Etretinate / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007645:Keratoderma, Palmoplantar / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D008875:Middle Aged; D010375:Pedigree; D014212:Tretinoin / Q000031:analogs & derivatives*
chemical_list: D014212:Tretinoin; D005050:Etretinate
vernacular_title: Keratosis palmoplantaris areata Siemens. Therapieversuch mit aramatischem Retinoid Ro 10-9359.