Effect of CO2 on peripheral flow and central hemodynamics.
A variable pattern of organ flow distribution was observed during experimental hypo- and hypercarbia. Mainly two patterns of organ flow changes emerged in that hepatic, renal and skeletal muscle flow showed a decreasing tendency during hypercarbia while gastrointestinal, myocardial and cerebral flow increased during hypercarbia and decreased during hypocarbia. These changes were accompanied by typical central hemodynamic changes including a decrease in systemic and pulmonary vascular resistance during both hypocarbia and hypercarbia which was also accompanied by decreased myocardial contractility.
D000818:Animals; D002245:Carbon Dioxide / Q000097:blood* / Q000494:pharmacology; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D006439:Hemodynamics; D011652:Pulmonary Circulation / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D002245:Carbon Dioxide