Influence of vitamin C on the metabolism of arachidonic acid and the development of aortic lesions during experimental atherosclerosis in rabbits.
Feeding rabbits a cholesterol-rich diet (0.3%) resulted in morphological changes and a decrease in the prostacyclin production by the aortic endothelium. Addition of vitamin C (0.1%) to the cholesterol-rich diet resulted in a decreased lipid infiltration and intimal thickening. Although there was a tendency to restore the prostacyclin output, vitamin C, in the amount administered, was unable to completely normalise the endothelial PGI2 production.
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000473:pathology*; D001013:Aorta, Thoracic / Q000378:metabolism; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D001161:Arteriosclerosis / Q000503:physiopathology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D002791:Cholesterol, Dietary; D004727:Endothelium / Q000187:drug effects / Q000378:metabolism; D011817:Rabbits
D001095:Arachidonic Acids; D002791:Cholesterol, Dietary; D016718:Arachidonic Acid; D001205:Ascorbic Acid