[So-called immunoglobulin-producing lymphoma with a case presentation and the production of monoclonal immunoglobulin M].
The authors discuss the B-cellular lymphomas, producing various kinds of monoclonal paraproteins as well as parts of them--light or heavy chains. A case of a patient with lymphoplasmocytic malignant lymphoma, producing monoclonal IgM in pentamer form mainly, as well as in Valdenström disease but without the symptoms characteristic for it--hyperviscosity and hemorrhagic diathesis, is described. The disease has been histologically, cytologically and electron microscopically diagnosed. Attention is paid to the long-term relatively benign course and subsequent malignant course with manifested laboratory changes as well as change in the objective state, requiring the monotherapy to be substituted for active complex treatment, though the effect was unsatisfactory, with a fatal outcome of the inflammatory complications and progressive anemia. The place of the case in Kiel classification of malignant lymphomas is discussed.
D001402:B-Lymphocytes / Q000276:immunology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis / Q000096:biosynthesis*; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000276:immunology* / Q000473:pathology; D008875:Middle Aged; D008258:Waldenstrom Macroglobulinemia / Q000276:immunology / Q000473:pathology
D007075:Immunoglobulin M
Vŭrkhu t. nar. imunoglobulini produtsirashti limfomi s predstaviane na sluchaĭ s proizvodstvo na monoklonalen imunoglobulin M.