title: Effect of streptozotocin diabetes on sialic acid content and glycoprotein binding of isolated hepatocytes.
abstract: The possible correlation between sialic acid content of hepatocyte plasma membranes, and their binding capacity was investigated. For that purpose, [3H] asialotransferrin binding was tested with hepatocytes from both normal and streptozotocin treated rats. The observed decrease in binding capacity was parallel to a decrease in the sialic acid content Insulin therapy restored simultaneously normal blood glucose level, hepatic membrane sialic acid content and binding capacity.
mesh_terms: D000818:Animals; D001212:Asialoglycoproteins; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D007328:Insulin / Q000097:blood / Q000627:therapeutic use; D008099:Liver / Q000166:cytology; D008297:Male; D051381:Rats; D012794:Sialic Acids / Q000378:metabolism*; D013311:Streptozocin; D014168:Transferrin / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D001212:Asialoglycoproteins; D001786:Blood Glucose; D007328:Insulin; D012794:Sialic Acids; D014168:Transferrin; C017031:asialotransferrins; D013311:Streptozocin