title: Plasma LH and FSH concentrations in prepubertal beef heifers before and in response to repeated injections of low doses of Gn-RH.
abstract: Blood samples were taken at 15-min intervals from prepubertal beef heifers, 6 aged 4 months and 6 aged 10 months, to determine plasma LH and FSH concentrations. Two animals of each age group were then subjected to 9 consecutive injections of 0.5, 2.0 or 5.0 micrograms Gn-RH at 2-h intervals. LH episodes were evident in all animals before treatment, and in 11/12 heifers occurred at a rate of between 1 and 4 per 24 h. One 10-month old heifer, later detected in oestrus, displayed 10 episodes/24 h. Mean FSH concentrations did not differ significantly between age groups. In all animals, Gn-RH injections induced an episodic pattern of LH secretion which was significantly different between Gn-RH doses, but not between age groups. A distinct episode-like response in FSH concentrations occurred to each Gn-RH injection in only one heifer. These results provide further evidence that the prepubertal period is associated with a lack of pituitary stimulation, rather than an inability to respond to Gn-RH.
mesh_terms: D000818:Animals; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood* / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood* / Q000378:metabolism; D010906:Pituitary Hormone-Releasing Hormones / Q000494:pharmacology*; D012636:Secretory Rate / Q000187:drug effects; D012741:Sexual Maturation
chemical_list: D010906:Pituitary Hormone-Releasing Hormones; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone