Trisomy 1q and loss of Y chromosome in a male with osteomyelosclerosis.
The results of a cytogenetic analysis of peripheral blood cells in a 61-year-old male with histopathologically documented osteomyelosclerosis, hepatosplenomegaly, ascites and anemia are described. The karyotype 46,X,-Y +1 p22----qter, without Ph1-chromosome, was observed in all unstimulated and in most PHA-stimulated cells. The patient had not received cytostatic or radiation therapy, thus the marker 1q + could not have resulted from such clastogenic treatments.
D002900:Chromosomes, Human, 1-3; D048909:Diabetes Complications; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000150:complications / Q000235:genetics*; D010026:Osteosclerosis / Q000150:complications / Q000235:genetics*; D012729:Sex Chromosome Aberrations; D014314:Trisomy; D014998:Y Chromosome