Inhibition of the uptake of nucleosides in cultured Harding-Passey melanoma cells by diflubenzuron.
Diflubenzuron (DFB) significantly inhibited the uptake of uridine, adenosine, and cytidine but not thymidine, in cultured Harding-Passey melanoma cells. Inhibition of nucleoside uptake was rapid (i.e., less than or equal to 5 min) and could not be reversed by washing. These results suggest that DFB may affect membrane properties and - as shown by in vivo tests - growth of melanoma cells.
D000818:Animals; D002460:Cell Line; D002463:Cell Membrane Permeability / Q000187:drug effects; D004132:Diflubenzuron / Q000494:pharmacology*; D007605:Juvenile Hormones / Q000494:pharmacology*; D008545:Melanoma / Q000378:metabolism*; D051379:Mice; D009705:Nucleosides / Q000378:metabolism*
D007605:Juvenile Hormones; D009705:Nucleosides; D004132:Diflubenzuron