Hereditary autosomal dominant form of bladder diverticula in male patients.
We report on 1 family in which 7 male patients had solitary bladder diverticulum. This family represents an autosomal dominant form of this disease by which only men are affected. Diverticula of the bladder can be classified as congenital (primary) or acquired (secondary). Vesical diverticula are uncommon in children and occur either primarily, when the vesical mucosa protrudes through a congenital defect in the bladder wall, or secondarily to bladder outflow obstruction. In adults the occurrence of multiloculated secondary diverticula is mainly due to subvesical obstruction. This seemingly autosomal dominant form of solitary diverticula in men was mostly associated with bladder outlet obstruction.
D000293:Adolescent; D004240:Diverticulum / Q000150:complications / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D010641:Phenotype; D012737:Sex Factors; D001745:Urinary Bladder Diseases / Q000235:genetics* / Q000473:pathology; D001748:Urinary Bladder Neck Obstruction / Q000150:complications