Attempts to enhance kidney allografts in DLA-identical dogs with specific anti-IA-like sera.
Attempts at enhancement of kidney allografts in DLA-identical dogs by injection of specific antidonor Ia-like antibodies or IgG are reported. Anti Ia-like sera were raised by immunization with allogeneic, splenocytes and subsequently adsorbed on platelets from the immunizing dog. Platelets were obtained from an average of 20 plasmaphoreses of each immunizing dog and from a pool of random mongrel dogs. No statistical differences were noticed either in survival time or blood urea levels in pairs of DLA-identical recipients (SD identical and negative mixed lymphocyte culture (MLC) engrafted with either the right donor kidney along with control normal dog sera or the left kidney of the same donor along with the specific antidonor Ia-like sera or IgG. The data indicate that an enhancement procedure easily performed in rodents is not reproducible in dogs.
D000818:Animals; D000918:Antibody Specificity; D004285:Dogs; D006085:Graft Survival; D007106:Immune Sera; D007074:Immunoglobulin G; D007519:Isoantigens / Q000276:immunology*; D016030:Kidney Transplantation; D007959:Lymphocyte Culture Test, Mixed; D013154:Spleen / Q000276:immunology; D014184:Transplantation, Homologous
D007106:Immune Sera; D007074:Immunoglobulin G; D007519:Isoantigens