Carbohydrate malabsorption in children with severe protein energy malnutrition.
To determine the incidence of carbohydrate malabsorption, particularly lactose malabsorption in Basotho children with severe PEM during treatment with a dry skim milk (DSM)-sucrose-oil mixture, 105 children with PEM were submitted to a Hydrogen Breath Test (HBT) after administration of the mixture. Carbohydrate malabsorption occurred more frequently in children with kwashiorkor (28/58) than in those with marasmus (5/33), marasmic kwashiorkor (3/15) and healthy controls (8/34). The positive HBT appeared to be due to lactose malabsorption in at least two thirds of the children with kwashiorkor as it turned negative when the challenge was repeated with a lactosefree mixture. In controls malabsorption of carbohydrate (usually lactose) appeared at the age of 22 months, nearly a year later than in PEM. Diarrhoea occurred in 23 children with PEM and particularly in those with carbohydrate malabsorption. In 20 children Giardia was found in the stools without any observable effect on carbohydrate malabsorption, however. The findings support the cautious use of physiological doses of lactose in the treatment of severe PEM.
D000818:Animals; D001944:Breath Tests; D002648:Child; D002675:Child, Preschool; D004040:Dietary Carbohydrates / Q000378:metabolism*; D002149:Energy Intake; D005260:Female; D006801:Humans; D006859:Hydrogen / Q000378:metabolism; D007223:Infant; D007732:Kwashiorkor / Q000378:metabolism; D007787:Lactose Intolerance / Q000175:diagnosis / Q000378:metabolism*; D007927:Lesotho; D008297:Male; D008892:Milk / Q000378:metabolism; D011502:Protein-Energy Malnutrition / Q000178:diet therapy / Q000378:metabolism*
D004040:Dietary Carbohydrates; D006859:Hydrogen