Influence of caffeine and 3-aminobenzamide in G2 on the frequency of chromosomal aberrations induced by thiotepa, mitomycin C and N-methyl-N-nitro-N'-nitrosoguanidine in human lymphocytes.
The effects of post-treatments with caffeine in G2 on the frequency of chromosomal aberrations induced by thiotepa, mitomycin C and N-methyl-N-nitro-N'-nitrosoguanidine were studied in human lymphocytes. Caffeine was found to potentiate the frequency of chromatid aberrations induced by all 3 S-dependent agents tested; the most striking enhancement being obtained when caffeine was present during the last 1.5 h before harvesting. Post-treatments in G2 with 3-aminobenzamide had no influence on the aberration frequency induced by thiotepa and N-methyl-N-nitro-N'-nitrosoguanidine.
D001549:Benzamides / Q000633:toxicity*; D002110:Caffeine / Q000633:toxicity*; D002453:Cell Cycle; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004260:DNA Repair / Q000187:drug effects; D004357:Drug Synergism; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D008937:Mitomycins / Q000494:pharmacology; D013852:Thiotepa / Q000494:pharmacology
D001549:Benzamides; D008937:Mitomycins; D008769:Methylnitronitrosoguanidine; D002110:Caffeine; C025160:3-aminobenzamide; D013852:Thiotepa