Response to carbon dioxide after oral midazolam and pentobarbitone.
Midazolam (15 mg), pentobarbitone (100 mg) and a placebo were administered orally to nine male volunteers in double-blind crossover studies and the effect on the ventilatory response to carbon dioxide was observed for periods of 6 hours. It was concluded that neither drug caused any significant degree of respiratory depression.
D000328:Adult; D000700:Analgesics / Q000494:pharmacology*; D001569:Benzodiazepines / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000502:physiology; D003864:Depression, Chemical; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D008874:Midazolam; D010424:Pentobarbital / Q000494:pharmacology*; D011897:Random Allocation; D012119:Respiration / Q000187:drug effects*; D013997:Time Factors
D000700:Analgesics; D001569:Benzodiazepines; D002245:Carbon Dioxide; D010424:Pentobarbital; D008874:Midazolam