Opposite action of m-chlorophenylpiperazine on avoidance depression induced by trazodone and pimozide in CD-1 mice.
m-Chlorophenylpiperazine (CPP) given in doses up to 2 mg/kg did not affect conditioned avoidance responses (CAR) of CD-1 mice pre-trained in a shuttle box. It reversed the inhibitory action of trazodone (10 mg/kg) on CAR, but dose-dependently potentiated the inhibitory effect of pimozide (0.2 and 0.5 mg/kg). Apparently, dopaminergic transmission is important for the attenuating effect of CPP on CAR inhibition.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003213:Conditioning, Psychological / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010868:Pimozide / Q000037:antagonists & inhibitors*; D010879:Piperazines / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D014196:Trazodone / Q000037:antagonists & inhibitors*
D010879:Piperazines; D010868:Pimozide; C015068:1-(3-chlorophenyl)piperazine; D014196:Trazodone