title: An enzymatic approach to biotransformation.
abstract: An overall scheme for the biotransformation of organic compounds by routes other than hydrolysis of possible ester bonds is presented. Both phase I (oxidative) and phase II (conjugative) biotransformation reactions are discussed on an enzyme by enzyme basis. Whenever possible pesticides are used as examples of the mechanisms by which enzyme activities alter chemical structure (biotransformation) as well as the ways in which chemicals themselves can effect enzyme activities.
mesh_terms: D000818:Animals; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004790:Enzyme Induction; D005260:Female; D014453:Glucuronosyltransferase / Q000096:biosynthesis; D005982:Glutathione Transferase / Q000096:biosynthesis; D006418:Heme / Q000378:metabolism; D006801:Humans; D008297:Male; D010575:Pesticides / Q000378:metabolism; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology
chemical_list: D010575:Pesticides; D000072317:Polychlorinated Dibenzodioxins; D006418:Heme; D003577:Cytochrome P-450 Enzyme System; D014453:Glucuronosyltransferase; D005982:Glutathione Transferase