Molecular cloning of a cDNA encoding human antihaemophilic factor.
A complete copy of the mRNA sequences encoding human coagulation factor VIII:C has been cloned and expressed. The DNA sequence predicts a single chain precursor of 2,351 amino acids with a relative molecular mass (Mr) 267,039. The protein has an obvious domain structure, contains sequence repeats and is structurally related to factor V and ceruloplasmin.
D000818:Animals; D000941:Antigens / Q000235:genetics; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D005169:Factor VIII / Q000235:genetics* / Q000276:immunology; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D008970:Molecular Weight; D012333:RNA, Messenger / Q000235:genetics; D013552:Swine
D000941:Antigens; D012333:RNA, Messenger; D005169:Factor VIII; D004247:DNA