[Changes in the length of sleep cycles during administration of flurazepam and lopirazepam].
The influence of narcotics on the duration of the ultradian NREM/REM cycle can be clearly recognized only when the first, particularly instable cycle is also included in the evaluation. A study with Lopirazepame and Flurazepame showed that compared to placebo Lopirazepame prolonged the first cycle particularly. In contrast with Flurazepame the first, but mainly the second cycle was shortened, and not until the third NREM/REM cycle the duration was compatible with that of placebo and Lopirazepame. The result is, that in nights of the same length Flurazepame shows a half or one cycle more compared to Lopirazepame.
D000293:Adolescent; D000328:Adult; D005260:Female; D005479:Flurazepam / Q000494:pharmacology*; D006801:Humans; D008140:Lorazepam / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D011619:Psychotropic Drugs / Q000494:pharmacology*; D012894:Sleep Stages / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects
D011619:Psychotropic Drugs; C025072:lopirazepam; D005479:Flurazepam; D008140:Lorazepam
Veränderungen der Dauer der Schlafzyklen unter Flurazepam und Lopirazepam.