Stability of noxythiolin solutions stored in plastic and glass containers.
The stability of two different concentrations (1% and 2.5% w/v) of noxythiolin (Noxyflex and Noxyflex S) stored at a variety of temperatures (4, 20 and 37 degrees C) in both plastic and glass bottles has been examined over a period of 40 days. During this period noxythiolin solutions held at 20 degrees and 37 degrees C attained equilibrium (K = 0.285 +/- 0.015 mol/l). Neither noxythiolin nor its degradation products (N-methylthiourea and formaldehyde) were absorbed by the plastic (polypropylene) containers used. Therefore, noxythiolin solutions can be stored in certain plastic (polypropylene) containers under the same conditions as recommended for glass bottles.
D000042:Absorption; D004349:Drug Packaging; D004355:Drug Stability; D004356:Drug Storage; D005557:Formaldehyde / Q000032:analysis; D005898:Glass; D006863:Hydrogen-Ion Concentration; D009677:Noxythiolin / Q000032:analysis*; D010969:Plastics; D013890:Thiourea / Q000031:analogs & derivatives* / Q000032:analysis; D013997:Time Factors
D010969:Plastics; D005557:Formaldehyde; D009677:Noxythiolin; C002267:N-methylthiourea; D013890:Thiourea