title: Inactivation of glucosamine-6-phosphate synthetase from Salmonella typhimurium LT 2 SL 1027 by N beta-fumarylcarboxyamido-L-2,3-diamino-propionic acid.
abstract: N beta- fumarylcarboxyamido -L-2,3-diaminopropionic acid ( FCDP ), a novel glutamine analog, inhibits the reaction of glucosamine-6-phosphate synthetase (EC 5.3.1.19) from Salmonella typhimurium LT 2 by irreversible inactivation of the enzyme. The kinetic data on enzyme inhibition and inactivation are presented. It is suggested that the enzyme inactivation occurs according to a sequential mechanism.
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives*; D002238:Carbohydrate Epimerases / Q000037:antagonists & inhibitors*; D005650:Fumarates / Q000494:pharmacology*; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / Q000037:antagonists & inhibitors*; D007700:Kinetics; D008956:Models, Chemical; D012486:Salmonella typhimurium / Q000201:enzymology*; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D005650:Fumarates; D015091:beta-Alanine; C041360:N(beta)-fumarylcarboxyamido-2,3-diaminopropionic acid; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); D002238:Carbohydrate Epimerases; D000409:Alanine