[The anticomplementary activity of 2 intravenous gamma globulin preparations in children with acute lymphatic leukemia].
Children with acute lymphocytic leukemia received gammaglobulin replacement therapy using either one of two i.v. gammaglobulin preparations in order to reduce the frequency and severity of infections during cytostatic treatment. Sera and EDTA-plasma taken prior to each infusion and following each infusion were analyzed for several complement components and immune complexes in order to assess in vivo anticomplementary activity. Preliminary data published in this paper show only little changes in the complement system. This may be related to fact that infusions were well tolerated. IgG-levels could be raised for more than 200 mg/dl by administration of doses around 150 mg/kg body weight.
D000293:Adolescent; D001798:Blood Proteins / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003167:Complement Activation; D003176:Complement C3 / Q000378:metabolism; D015933:Complement C3d; D003181:Complement C4 / Q000378:metabolism; D003165:Complement System Proteins / Q000378:metabolism*; D006801:Humans; D007116:Immunization, Passive; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000276:immunology* / Q000378:metabolism; D016756:Immunoglobulins, Intravenous; D007223:Infant; D007263:Infusions, Parenteral; D007945:Leukemia, Lymphoid / Q000628:therapy*
D001798:Blood Proteins; D003176:Complement C3; D003181:Complement C4; D007074:Immunoglobulin G; D016756:Immunoglobulins, Intravenous; D015933:Complement C3d; D003165:Complement System Proteins
Untersuchungen zur Antikomplementarität von zwei i.v.-Gammaglobulinpräparaten bei Kindern mit akuter lymphatischer Leukämie.