Mistabron effects on platelets and blood coagulation.
The mucolytic drug Mistabron is often used in bleeding situations. The purpose of this study is to assess the safety of this drug in such circumstances. The platelet function of human blood is not impaired by clinically used Mistabron dosage, after stimulation with epinephrine, ADP or arachidonic acid. Coagulation proteins are not modified by Mesna, neither in vitro (blood from human beings), nor in vivo (rats).
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D006801:Humans; D008623:Mercaptoethanol / Q000031:analogs & derivatives*; D015080:Mesna / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats
D008623:Mercaptoethanol; D015080:Mesna