Multiple neoplasms in hairy cell leukaemia.
A patient who presented simultaneously with typical hairy cell leukaemia (HCL) and multiple myeloma (MM) is described. He was treated with melphalan and irradiation and 18 months later presented with an adenocarcinoma. The occurrence of multiple neoplasms in this patient may reflect an underlying predisposition to neoplasia secondary to the immunological defects common in B cell lymphoproliferative diseases.
D000230:Adenocarcinoma / Q000150:complications*; D000368:Aged; D001803:Blood Transfusion; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007145:Immunoglobulin kappa-Chains / Q000276:immunology; D007421:Intestine, Small / Q000601:surgery; D007943:Leukemia, Hairy Cell / Q000150:complications*; D008297:Male; D008558:Melphalan / Q000627:therapeutic use; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy / Q000532:radiotherapy; D010950:Plasma Cells / Q000276:immunology; D013156:Splenectomy
D007070:Immunoglobulin A; D007145:Immunoglobulin kappa-Chains; D008558:Melphalan