Magnetic microcapsules for targeted delivery of anticancer drugs.
To achieve targeted distribution of anticancer drugs with sustained activity, ferromagnetic ethylcellulose microcapsules containing an anticancer drug, mitomycin C (FM-MMC-mc), were prepared by a method based on phase separation principles. Two prototypes of FM-MMC-mc were made: one with the drug as the core and zinc ferrite on its capsular surface (outer type); the other with both the drug and zinc ferrite as the core (inner type). Both preparations provided a sustained-release property and a sensitive response to conventional magnetic force, although certain differences in the release rate of drug, magnetic responsiveness, and particle size were found between the two dosage forms. Animal studies showed that the magnetic microcapsules could be magnetically controlled in the artery and urinary bladder. VX2 tumors in the rabbit hind limb and urinary bladder were successfully treated with magnetic control of FM-MMC-mc. Pharmacokinetic study revealed that the targeting of the microcapsules markedly enhanced the drug absorption into the surrounding tissues for a prolonged period of time. The results indicate the feasibility and effectiveness of the magnetic microcapsules as a targeted drug delivery system.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001011:Aorta / Q000378:metabolism; D002214:Capsules; D002482:Cellulose / Q000031:analogs & derivatives; D004285:Dogs; D005290:Ferric Compounds; D008280:Magnetics; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011817:Rabbits; D001743:Urinary Bladder / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy
D000970:Antineoplastic Agents; D002214:Capsules; D005290:Ferric Compounds; D008937:Mitomycins; C001215:ferrite; D016685:Mitomycin; C013517:ethyl cellulose; D002482:Cellulose