Human opsonins to meningococci after vaccination.
Two groups of volunteers were immunized with either a serogroup A plus C meningococcal polysaccharide vaccine or a combined serogroup B polysaccharide-serotype 2 protein vaccine. Serum opsonin responses were measured by chemiluminescence of polymorphonuclear leukocytes exposed to opsonized live meningococci. Two of the six volunteers immunized with the A plus C vaccine had an increase in serum opsonins to group A meningococci, four responded to group C meningococci, and none to group B meningococci. Five other volunteers who were immunized with the combined group B polysaccharide-serotype 2 protein vaccine responded with an increase in serum opsonins to group B meningococci of two different protein serotypes, as well as to a group C-serotype 2 meningococcal strain. Although no booster effect was observed after a second dose of the combined vaccine, both the polysaccharide and the protein components appear to be able to stimulate an opsonin response.
D001428:Bacterial Vaccines / Q000276:immunology*; D001770:Blood Bactericidal Activity; D006801:Humans; D008589:Meningococcal Infections / Q000276:immunology / Q000517:prevention & control; D009345:Neisseria meningitidis / Q000276:immunology*; D009895:Opsonin Proteins / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000276:immunology; D013997:Time Factors; D014611:Vaccination
D001428:Bacterial Vaccines; D009895:Opsonin Proteins; D011135:Polysaccharides, Bacterial