[Anti-inflammatory effect of aluminum or aurin tricarboxylic acid].
The anti-inflammatory effect of aurin tricarboxylic acid is studied in rats after parenteral injection of 20 and 50 mg/kg. Aurin tricarboxylic acid reduces: the carrageenan-induced oedemas in paws, the carragenan-induced pleural effusion, the carragen-induced granulation tissue growth and the Freund adjuvant-induced arthritis. As non steroïdal antiinflammatory drugs, the aurin tricarboxylic acid inhibits (ED50 = 0.34.10-2 M) the human erythrocyte delta aminolevulinic acid dehydratase, a zinc dependent enzyme. A possible interaction between zinc-enzymes and non steroïdal antiinflammatory compounds is suggested.
D000818:Animals; D000893:Anti-Inflammatory Agents; D001312:Aurintricarboxylic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D002351:Carrageenan; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy*; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D007700:Kinetics; D000623:Porphobilinogen Synthase / Q000097:blood; D051381:Rats
D000893:Anti-Inflammatory Agents; D003509:Cyclohexanecarboxylic Acids; D001312:Aurintricarboxylic Acid; D002351:Carrageenan; D000623:Porphobilinogen Synthase
Mise en évidence de l'action anti-inflmmatoire de l'aluminon ou acide aurine tricarboxylique.