Role of activated protein C on platelet aggregation induced by thrombin.
Platelets aggregate with thrombin-free activated protein C in concentrations higher than physiological levels. Aggregation was dependent on an intact release mechanism since inhibition of aggregation occurred with adenosine or EDTA. However, activated protein C reduced the sensitivity of platelets to aggregate in the presence of thrombin. Probably, activated protein C competes for membrane sites sensitive to thrombin.
D000241:Adenosine / Q000494:pharmacology; D001665:Binding Sites; D004492:Edetic Acid / Q000494:pharmacology; D006023:Glycoproteins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D011486:Protein C; D013917:Thrombin / Q000494:pharmacology*
D006023:Glycoproteins; D011486:Protein C; D004492:Edetic Acid; D013917:Thrombin; D000241:Adenosine