Antitumor-promoting activity of glycyrrhetic acid in mouse skin tumor formation induced by 7,12-dimethylbenz[a]anthracene plus teleocidin.
Glycyrrhetic acid inhibited the action of tumor promoter in vitro and in vivo. Glycyrrhetic acid inhibited the increased phospholipid metabolism of cultured cells induced by tumor promoters, 12-O-tetradecanoylphorbol-13-acetate or teleocidin, and it markedly suppressed the promoting effect of teleocidin on skin tumor formation in mice initiated with 7,12-dimethylbenz[a]anthracene.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002273:Carcinogens; D006034:Glycyrrhetinic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D008235:Lyngbya Toxins / Q000633:toxicity*; D051379:Mice; D008813:Mice, Inbred ICR; D010743:Phospholipids / Q000378:metabolism; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000517:prevention & control
D002273:Carcinogens; D008235:Lyngbya Toxins; D010743:Phospholipids; C022176:teleocidins; D015127:9,10-Dimethyl-1,2-benzanthracene; D006034:Glycyrrhetinic Acid