Deficiency of interleukin-2 production and interleukin-2 receptor expression on peripheral blood leukocytes after phytohemagglutinin stimulation in pemphigus.
Peripheral blood mononuclear cells from 22 pemphigus patients with active disease and 30 normal subjects were evaluated for interleukin 2 (IL-2) production and IL-2 receptor expression following stimulation with phytohemagglutinin P (PHA-P). The IL-2 levels were lower in patients compared to corresponding controls and the production was delayed after PHA stimulation. This deficiency was most pronounced in severely affected patients. IL-2 receptor appearance also was lower after PHA stimulation in a small number of patients tested. These results indicate that some cellular immune functions are altered in pemphigus.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007376:Interleukin-2 / Q000032:analysis / Q000096:biosynthesis*; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects / Q000276:immunology*; D010392:Pemphigus / Q000276:immunology*; D010835:Phytohemagglutinins / Q000494:pharmacology*; D011971:Receptors, Immunologic / Q000032:analysis* / Q000187:drug effects; D015375:Receptors, Interleukin-2
D007376:Interleukin-2; D010835:Phytohemagglutinins; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2