title: Inhibition of normal rat macrophage functions by soluble tumor products. Effect of systemic treatment with bacterial immunomodulators.
abstract: The phagocytic and chemotactic activities of normal rat peritoneal macrophages were inhibited by sera from tumor-bearing rats (TBR) and 3 M KCl extracts of tumor mass. However, sera from Corynebacterium parvum- or Listeria monocytogenes-treated TBR did not inhibit phagocytosis. On the other hand, sera from C. parvum-treated, but not from L. monocytogenes-treated TBR still inhibited the chemotactic response of the normal macrophages. Furthermore, 3 M KCl extracts of tumors from C. parvum-treated TBR did not inhibit phagocytosis and chemotactic response of the same cells. Similar results were obtained with extracts of tumor masses from L. monocytogenes-treated rats. It is suggested that treatment with bacterial immunomodulators can influence the release from neoplastic cells of soluble products influencing normal macrophage functions.
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D002633:Chemotaxis; D003352:Corynebacterium / Q000276:immunology; D005260:Female; D006801:Humans; D008089:Listeria monocytogenes / Q000276:immunology; D008264:Macrophages / Q000502:physiology*; D008297:Male; D009374:Neoplasms, Experimental / Q000276:immunology*; D010587:Phagocytosis; D051381:Rats
chemical_list: D000276:Adjuvants, Immunologic