The characterization of chromosome breaks in Drosophila melanogaster. I. Mass isolation of deficiencies which have an end point in the 14A-15A region.
A total of 2.7 X 10(6) chromosomes have been screened for deficiencies that extend into some portion of the 14A-15A segment of the X-chromosome. Mutants have been identified on the basis of their paralysis at high temperature (the para ts phenotype) in a stock which contains a para ts allele on the X-chromosome and a para+ allele on the Dp(1;4)r+f+ chromosome. Several hundred mutants have been genetically characterized and a large percentage are deficiencies. Cytological characterization of a sub-set suggests that breakpoints are distributed throughout the 14B-15A region, but in a non-random fashion.
D000818:Animals; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D002875:Chromosomes / Q000648:ultrastructure; D004331:Drosophila melanogaster / Q000235:genetics*; D009154:Mutation