title: A study of cefoperazone alone and in combination with tobramycin against Pseudomonas aeruginosa.
abstract: The minimum inhibitory concentrations (MICs) of cefoperazone for 507 clinical isolates of Pseudomonas aeruginosa were measured by plate dilution technique. On a cumulative percentage basis, 81% of isolates were inhibited by less than or equal 3.13 microgram/ml of cefoperazone. The minimum bactericidal concentration (MBC) was found to be generally twice the MIC. Synergy occurred between cefoperazone and tobramycin, judged by a lowering of the MIC in 69% of isolates, for which the MIC of cefoperazone alone was less than or equal to 6.2 microgram/ml.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002438:Cefoperazone; D002511:Cephalosporins / Q000494:pharmacology*; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D014031:Tobramycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002438:Cefoperazone; D014031:Tobramycin