Influence of 2-mercaptopropionylglycine on DMBA-induced biochemical changes in regenerating mouse liver: II. Glucose-6-phosphate dehydrogenase, malic enzyme DNA, and protein.
Present investigation documents the influence of 2-mercaptopropionylglycine, a hepatropic detoxicant, on glucose-6-phosphate dehydrogenase, malic enzyme, DNA, and total protein contents in regenerating mouse liver exposed to a chemical carcinogen--DMBA. DMBA, when given alone, decreases the levels of these macromolecular constituents in the regenerating liver. When MPG is given with DMBA, the levels of these, except that of G6P-DH, are maintained at control levels.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology*; D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D000818:Animals; D004247:DNA / Q000378:metabolism*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008115:Liver Regeneration / Q000187:drug effects*; D008291:Malate Dehydrogenase / Q000378:metabolism*; D051379:Mice; D011506:Proteins / Q000378:metabolism*; D008625:Tiopronin / Q000494:pharmacology*
D000603:Amino Acids, Sulfur; D011506:Proteins; D015127:9,10-Dimethyl-1,2-benzanthracene; D004247:DNA; D008625:Tiopronin; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase