A new antitumor antibiotic, kazusamycin.
A new antibiotic kazusamycin, was isolated from the culture broth of Streptomyces sp. No. 81-484, which shows antitumor activity against experimental murine tumors. This antibiotic did not possess antibacterial activity against Gram-positive and Gram-negative bacteria, but showed strong cytotoxic activity against HeLa cells in vitro. The chemical and physico-chemical properties of kazusamycin suggest that the molecular formula of this antibiotic is C33H48O7 (MW 556).
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology / Q000627:therapeutic use; D005231:Fatty Acids, Unsaturated; D005285:Fermentation; D006367:HeLa Cells / Q000187:drug effects; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008826:Microbial Sensitivity Tests; D012510:Sarcoma 180 / Q000188:drug therapy; D013302:Streptomyces / Q000032:analysis
D000903:Antibiotics, Antineoplastic; D005231:Fatty Acids, Unsaturated; C042541:kazusamycin A