Opsonic, cytotoxic, precipitating, blocking of bacterial adherence, and other activities of monoclonal IgE antibody compared with IgA and IgM.
Monoclonal IgE anti-TNP antibodies were compared with monoclonal anti-TNP, IgM and IgA isotypes in different biological reactions. The reaginic activity of IgE antibodies demonstrated in passive cutaneous anaphylaxis reactions and degranulation of mast cells was accompanied by a number of activities known to be associated with other isotypes. The occurrence of relatively high numbers of lymphoid cells and macrophages bearing Fc epsilon receptors suggests a possible role of IgE antibodies in host defence mechanisms acting systematically and/or locally on mucosal surfaces.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000920:Antibody-Dependent Cell Cytotoxicity; D000941:Antigens / Q000276:immunology; D004926:Escherichia coli / Q000276:immunology; D005779:Immunodiffusion; D007070:Immunoglobulin A / Q000276:immunology; D007126:Immunoglobulin Allotypes / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology; D037102:Lectins / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009895:Opsonin Proteins / Q000276:immunology; D010587:Phagocytosis; D011961:Receptors, Fc / Q000032:analysis; D014301:Trinitrobenzenes / Q000276:immunology
D000911:Antibodies, Monoclonal; D000941:Antigens; D007070:Immunoglobulin A; D007126:Immunoglobulin Allotypes; D007075:Immunoglobulin M; D037102:Lectins; D009895:Opsonin Proteins; D011961:Receptors, Fc; D014301:Trinitrobenzenes; D007073:Immunoglobulin E