[Effect of total parenteral nutrition on the nutritional status and immunocompetence in host and on the tumor growth].
Present study was undertaken to reveal the effects of total parenteral nutrition (TPN) on the immunocompetence associated with nutritional status and on the tumor growth. The 4-nitro-quinoline-1-oxide induced Sato Lung Carcinoma was transplanted subcutaneously on the back of Donryu rats. Rats were controlled by TPN, low calorie infusion or oral feeding for one or two weeks. Each group was subdivided into chemotherapy and non chemotherapy group. Chemotherapy was performed with adriamycin or ACNU. Tumor bulk was bigger in the well nourished TPN rats than in malnourished group, revealing an accelerated tumor growth by TPN. Despite no significant change in polyamine level and phosphorylation activity, thymidine kinase activity and mitotic index in tumor were significantly higher in TPN than in low calorie infusion. Compared to the results of low calorie infusion, higher activity of IgG, IgM plaque forming cells and lymphocytic blastformation by PHA was suggested the good maintenance of both cellular and humoral immunity in well nourished rats. There was no positive evidence to support the facilitated effect of chemotherapeutic agents in TPN. However, TPN decreased an incidence of adverse reactions of chemotherapy such as loss of weight, leukopenia. Survival rate of rats at nine weeks after treatment also showed the favorable effect of TPN on chemotherapy.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001835:Body Weight; D004273:DNA, Neoplasm / Q000032:analysis; D004317:Doxorubicin / Q000627:therapeutic use; D007121:Immunocompetence; D008112:Liver Glycogen / Q000378:metabolism; D008175:Lung Neoplasms / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D008213:Lymphocyte Activation; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology / Q000473:pathology / Q000628:therapy; D015376:Nimustine; D009607:Nitrosourea Compounds / Q000627:therapeutic use; D010288:Parenteral Nutrition; D010289:Parenteral Nutrition, Total; D051381:Rats; D011919:Rats, Inbred Strains; D013937:Thymidine Kinase / Q000097:blood
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D008112:Liver Glycogen; D009607:Nitrosourea Compounds; D015376:Nimustine; D004317:Doxorubicin; D013937:Thymidine Kinase