title: Alfentanil and skeletal muscle circulation, oxygen consumption and P50.
abstract: The preservation of blood flow to skeletal muscles has low priority in the intact organism. If cardiovascular function is disturbed, for example by anesthetic drugs, skeletal muscle circulation diminishes or stops. Skeletal muscle surface pH (m-pH) is a sensitive indicator of muscle cell oxygenation and a fall in m-pH therefore provides an early warning of deterioration in overall cardiovascular performance. In the present study we investigated the peripheral effects of a new short-acting fentanyl derivative, alfentanil. Twelve dogs were anesthetized with a bolus injection of alfentanil 0.16 mg . kg-1 i.v. M-pH was recorded continuously, while total body oxygen consumption, oxygen transport and P50 were calculated. No changes were found. In the second part of the study, we pretreated six of the dogs with the "calcium antagonist" verapamil 0.5 mg X kg-1, while the other six dogs served as controls. After a rechallenge dose of alfentanil, we again found the peripheral perfusion sufficient to meet the oxygen demand of the muscles. Side-effects to alfentanil were a decrease in Pao2, due to an increase in pulmonary shunting of venous blood, and an increase in PaCO2. The changes in pulmonary ventilation-perfusion relationships were, however, not of a magnitude that should cause concern when alfentanil is used in normal subjects.
mesh_terms: D000759:Adjuvants, Anesthesia / Q000494:pharmacology*; D015760:Alfentanil; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004285:Dogs; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D009132:Muscles / Q000098:blood supply*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects*; D012039:Regional Blood Flow / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology
chemical_list: D000759:Adjuvants, Anesthesia; D002245:Carbon Dioxide; D015760:Alfentanil; D014700:Verapamil; D010100:Oxygen; D005283:Fentanyl