[Acute hepatic necrosis and hemorrhagic syndrome leading to a fatal outcome during treatment of hypercalcemia with mithramycin (author's transl)].
The onset of hepatic necrosis and a hemorrhagic syndrome, leading to a fatal outcome, was attributed to the toxicity of mithramycin prescribed for an iatrogenic hypercalcemia. This toxicity limits the use of mithramycin for the treatment of hypercalcemias.
D000208:Acute Disease; D000328:Adult; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D006934:Hypercalcemia / Q000139:chemically induced / Q000188:drug therapy*; D008107:Liver Diseases / Q000473:pathology; D009336:Necrosis; D008926:Plicamycin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
D008926:Plicamycin
Nécrose hépatique aiguë et syndrome hémorragique mortel au décours d'une hypercalcémie traitée par la mithramycine.