title: Prolactin plasma levels and oral contraceptives at low dosage.
abstract: In the present study the Authors consider whether estroprogestins at low dosage may influence the basal levels of plasma Prolactin in a group of patients subdivided on the basis of their different ways of life. The results show that oral contraceptives containing 30 microgrammes of EE do not induce modifications on PRL levels; however these are significantly (p less than or equal to 0.01) lower in the smoker group. It has therefore been hypothesised that smoke may interfere with the regulatory mechanisms of PRL, even if the practical effects of such action in the ambit of the physiopathology of reproduction is not yet clear.
mesh_terms: D000293:Adolescent; D000328:Adult; D003276:Contraceptives, Oral / Q000008:administration & dosage*; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006801:Humans; D016912:Levonorgestrel; D009644:Norgestrel / Q000008:administration & dosage / Q000494:pharmacology; D011388:Prolactin / Q000097:blood*; D012907:Smoking
chemical_list: D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D009644:Norgestrel; D004997:Ethinyl Estradiol; D016912:Levonorgestrel; D011388:Prolactin