title: N,N'-bis(S-benzoylmercaptoacetamido) ethylenediamine and propylenediamine ligands as renal function imaging agents. I. Alternate synthetic methods.
abstract: A new method was developed to synthesize tetradentate ligands containing the N,N'-bis(S- benzoylmercaptoacetyl ) ethylenediamine and propylenediamine moieties (DADS compounds). Methods are also represented with which to synthesize some of the positional isomers of the above compounds. These isomers represent a new class of compounds. A total of 21 different compounds were prepared. These will be used in an effort to establish a relationship between structure and renal imaging properties.
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives*; D055598:Chemical Phenomena; D002621:Chemistry; D005029:Ethylenediamines / Q000138:chemical synthesis*; D008024:Ligands; D011866:Radioisotope Renography; D013329:Structure-Activity Relationship; D015091:beta-Alanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis
chemical_list: D005029:Ethylenediamines; D008024:Ligands; D015091:beta-Alanine; C041730:N,N'-bis(S-benzoylmercaptoacetamido)ethylenediamine; C041731:N,N'-bis(S-benzoylmercaptoacetyl)-2,3-diaminopropionic acid ethyl ester; D000409:Alanine