[Action of the chalone from Ehrlich's ascites, tumor in mice on the mitotic activity in this tumor after single and double administrations].
Chalone from Ehrlich's ascites tumour exerts a short-lived and reversible inhibitory effect on cell proliferation in the tumour both after a single and two-fold administration. 10 hours following single and two-fold injection of chalone (second injection was given at 6 p.m.), the mitotic index in tumour cells rises as compared to controls an evidence of chalone action on G(2) cell population of the mitotic cycle and synchronization of cell division. Repeated injection of chalone at 9 p.m. results in a more prolonged effect on the cells and in a more pronounced synchronization wave of G(2) cell population comparatively to its injection at 6 p.m. Thus the duration of cell inhibition in G(2) phase of the mitotic cycle depends with repeated administration of chalone, on the condition of cell population affected by chalone.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D006131:Growth Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008938:Mitosis / Q000187:drug effects*; D013997:Time Factors
D006131:Growth Inhibitors
Deĭstvie keĭlona iz astsitnoĭ opukholi Erlikha mysheĭ na mitoticheskuiu aktivnost' v étoĭ opukholi posle odnokratnogo i dvukratnogo ego vvedeniia.