Systolic and diastolic time intervals during spontaneous angina.
In 5 patients who suffered spontaneous angina during cardiac catheterization, aortic pressure and electrocardiographic lead (V5) were recorded at rest, at the onset of anginal pain, 5 and 10 min after 0.6 mg sublingual nitroglycerin (NTG). Heart rate, systemic arterial pressure, systolic, and diastolic time intervals were measured. Heart rate and systemic arterial pressure rose significantly immediately after the onset of angina and declined progressively within 10 min from NTG administration. Preejection period did not change during angina, while left ventricular ejection time and electromechanical systole lengthened. As a consequence, diastolic time, expressed as percent of cardiac cycle, shortened sharply. All parameters considered went back to basal values within 10 min from NTG administration, and were preceded by relief or reduction of anginal pain. We concluded that a fall in diastolic time, secondary to a prolongation of electromechanical systole occurring during angina, may further increase the degree of ischemia resulting in a vicious cycle than can be interrupted by NTG administration.
D000787:Angina Pectoris / Q000188:drug therapy / Q000503:physiopathology*; D001794:Blood Pressure / Q000187:drug effects; D006328:Cardiac Catheterization; D003326:Coronary Circulation / Q000187:drug effects; D003971:Diastole / Q000187:drug effects; D004562:Electrocardiography / Q000379:methods*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects; D005996:Nitroglycerin / Q000627:therapeutic use; D013599:Systole / Q000187:drug effects; D013997:Time Factors
D005996:Nitroglycerin