[Effects of inhibin on the in vitro synthesis of desoxyribonucleic acid in the rat testis].
Three preparations of inhibin extracted from ram rete testis fluid (RTF) and from human seminal plasma (HSP) reduce tritiated thymidine incorporation into testicular desoxyribonucleic acids (DNA) in vitro. Effect of low molecular inhibin from RTF is dose-dependent. Castrated ram serum does not modify testicular DNA synthesis in vitro. Besides their suppressive action on follicle stimulating hormone (FSH) secretion in vivo and in vitro, these inhibin preparation display a direct inhibiting effect on testicular DNA synthesis and, thus, on mitotic activity. Identity between inhibin and testicular chalones are discussed.
D000818:Animals; D004247:DNA / Q000096:biosynthesis*; D006728:Hormones / Q000494:pharmacology*; D006801:Humans; D007265:Inhibins; D008297:Male; D011506:Proteins / Q000494:pharmacology*; D051381:Rats; D012756:Sheep; D013735:Testicular Hormones / Q000494:pharmacology*; D013737:Testis / Q000187:drug effects* / Q000378:metabolism
D006728:Hormones; D011506:Proteins; D013735:Testicular Hormones; D007265:Inhibins; D004247:DNA
Effet de l'inhibine sur la synthèse de l'acide désoxyribonucléique du testicule du rat in vitro.