[Tumor immunity induced by local radiotherapy].
The tumor-specific immunopotential was obtained by local X-irradiation to tumor under certain condition. This radiation-induced tumor-specific immunity did not effectively manifest in in vivo system due to suppressor cells. Combined effect of radiotherapy and cyclophosphamide, which reduced presuppressor cells, was examined in the murine tumor system. C3H/He mice with transplantable Fibrosarcoma was used. Tumor was locally irradiated by 8MeV Electron beam (LMT-15). Tumors were treated when they grew at 8 +/- 1 mm in size. Tumor growth curve and tumor regrowth time were studied. Suppression of tumor growth was noticed in the combined treatment group of irradiation and cyclophosphamide. Treatment of cyclophosphamide after irradiation was effective to tumor.
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D005354:Fibrosarcoma / Q000276:immunology / Q000473:pathology / Q000532:radiotherapy; D007111:Immunity, Cellular / Q000528:radiation effects; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy; D012513:Sarcoma, Experimental / Q000276:immunology* / Q000473:pathology / Q000532:radiotherapy
D003520:Cyclophosphamide