HLA-ABC and DR antigens in celiac disease. A study in a pediatric Italian population.
HLA phenotypes of 64 Italian pediatric patients with celiac disease (CD) were compared with those of a group of healthy controls. DR3 and DR7 are significantly increased as reported in other populations. In addition an increase of heterozygotes DR5/DR7 was observed in our patients. The Hardy-Weinberg distribution in the patients group shows a disequilibrium due to the genotype DR5/DR7. Our data confirm that more than one HLA gene product is associated with CD: one with DR3 and the other with DR7.
D000293:Adolescent; D002446:Celiac Disease / Q000235:genetics / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005787:Gene Frequency; D005802:Genes, MHC Class II; D005828:Genetics, Population; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006684:HLA-DR Antigens; D006801:Humans; D007223:Infant; D007558:Italy
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006684:HLA-DR Antigens