title: Influence of STS 557 on the mitotic activity in the endometrium of ovariectomized mice and comparison with the effects of progesterone and levonorgestrel.
abstract: The numbers of mitoses in the epithelial and stromal tissues of mouse uteri were recorded after treatment with various doses of progesterone (P), levonorgestrel (LN), and STS 557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4,9(10)-diene-3-one). All three progestins induced mitotic activity in the stromal tissue of the endometrium in which P and LN were much more active than STS 557. While the cell divisions in the luminal and glandular epithelium induced by P were only rare, LN and STS 557 enhanced the mitosis rates in these tissues significantly at a daily dose of 1.0 mg/animal on 5 consecutive days. The results are discussed with special regard to the post-coital antifertility effect of STS 557.
mesh_terms: D000818:Animals; D002369:Castration; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology; D004717:Endometrium / Q000166:cytology / Q000187:drug effects*; D005260:Female; D016912:Levonorgestrel; D051379:Mice; D008938:Mitosis / Q000187:drug effects*; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D009644:Norgestrel / Q000494:pharmacology*; D011374:Progesterone / Q000494:pharmacology*
chemical_list: D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D009644:Norgestrel; C023635:dienogest; D011374:Progesterone; D016912:Levonorgestrel; D009277:Nandrolone