Abnormal processing of antral gastrin in active duodenal ulcer disease.
The concentrations of gastrins containing the active C-terminal tetrapeptide amide (mainly gastrin-34 and gastrin-17) and the N-terminal tridecapeptide fragment of gastrin-17 were measured in antral and duodenal biopsy specimens. The antral concentration of the N-terminal gastrin fragment was much higher in patients with active duodenal ulcer (33.4 +/- 6.8 nmol g-1, mean +/- SEM, n = 15) than in controls (5.6 +/- 2.9 nmol g-1, n = 10), patients with gastric ulcer (5.6 +/- 1.8 nmol g-1, n = 10) or patients with pernicious anaemia (7.7 +/- 2.5 nmol g-1, n = 6). No differences were found between the groups regarding gastrin-34 and gastrin-17 concentrations. In duodenal extracts, the N- and C-terminal gastrin concentrations were similar in all groups of patients. These data suggest that the posttranslational processing of antral gastrin is abnormal in patients with active duodenal ulcer disease.
D000328:Adult; D000368:Aged; D000752:Anemia, Pernicious / Q000378:metabolism; D002850:Chromatography, Gel; D004381:Duodenal Ulcer / Q000378:metabolism*; D005260:Female; D005755:Gastrins / Q000378:metabolism*; D006728:Hormones / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011498:Protein Precursors; D011706:Pyloric Antrum / Q000378:metabolism; D011863:Radioimmunoassay; D013276:Stomach Ulcer / Q000378:metabolism
D005755:Gastrins; D006728:Hormones; D011498:Protein Precursors; C013706:big gastrin; C013550:gastrin 17