Cerebral infarction in systemic lupus: association with anticardiolipin antibodies.
We report fifteen patients, thirteen with systemic lupus and two patients with a "lupus-like" illness who developed cerebral infarction. All fifteen patients were shown to have elevated anticardiolipin antibody levels using a newly devised solid phase radioimmunoassay. The lupus anticoagulant was detected in all eleven patients tested. It is proposed that anticardiolipin antibodies and the lupus anticoagulant make up a population of antiphospholipid antibodies capable of causing cerebral vascular injury and thrombosis resulting in cerebral infarction. These antibodies may also play a pathogenic role in autoimmune disorders other than lupus where cerebral thrombotic disease is a prominent feature.
D000328:Adult; D000906:Antibodies / Q000032:analysis / Q000502:physiology*; D001779:Blood Coagulation Factors / Q000032:analysis / Q000037:antagonists & inhibitors / Q000502:physiology; D002308:Cardiolipins / Q000032:analysis / Q000276:immunology* / Q000502:physiology; D002544:Cerebral Infarction / Q000209:etiology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D016682:Lupus Coagulation Inhibitor; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000502:physiology; D011863:Radioimmunoassay
D000906:Antibodies; D001779:Blood Coagulation Factors; D002308:Cardiolipins; D016682:Lupus Coagulation Inhibitor; D010743:Phospholipids