Complete amino acid sequence of human seminal plasma beta-inhibin. Prediction of post Gln-Arg cleavage as a maturation site.
The complete sequence of a 94 amino acid human seminal plasma polypeptide exhibiting inhibin-like activity is presented. This molecule, called beta-inhibin, selectively and specifically suppresses the release of pituitary FSH in vivo as well as in vitro. It does not affect the secretion of LH. Such a novel acidic protein contains a very basic C-terminal segment which is easily cleaved by mild tryptic digestion. It is predicted that the FSH inhibiting activity may reside within this region of the molecule. This would imply a post Gln-Arg cleavage to release the basic C-terminal active moiety.
D000595:Amino Acid Sequence; D000818:Animals; D001120:Arginine; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D005973:Glutamine; D006801:Humans; D007202:Indicators and Reagents; D007265:Inhibins / Q000302:isolation & purification* / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D051379:Mice; D010446:Peptide Fragments / Q000032:analysis; D010455:Peptides / Q000302:isolation & purification*; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D029584:Prostatic Secretory Proteins; D051381:Rats; D012661:Semen / Q000032:analysis*; D014357:Trypsin / Q000378:metabolism
D007202:Indicators and Reagents; D010446:Peptide Fragments; D010455:Peptides; D029584:Prostatic Secretory Proteins; C043076:beta-microseminoprotein; D005973:Glutamine; D007265:Inhibins; D005640:Follicle Stimulating Hormone; D001120:Arginine; D014357:Trypsin