Production and properties of a bacteriocin from Myxococcus coralloides D.
Myxococcus coralloides D was found to produce a substance with a narrow range of antibacterial activity. This substance was produced during the exponential growth phase and was not inducible by ultraviolet light or mitomycin C treatment. The bacteriocin was precipitable by ammonium sulphate, and showed resistance to heat (100 degrees C for 10 min), trypsin, lysozyme, beta-glucuronidase, DNase, RNase, acetone, ethyl ether, urea and mercaptoethanol; it was partially destroyed by pronase and inactivated at extreme pH values. Electron microscopy did not reveal any phage-like particles associated with bacteriocin activity.
D001419:Bacteria / Q000187:drug effects; D001430:Bacteriocins / Q000096:biosynthesis* / Q000494:pharmacology; D001435:Bacteriophages / Q000648:ultrastructure; D002850:Chromatography, Gel; D008854:Microscopy, Electron; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D009231:Myxococcales / Q000378:metabolism*
D001430:Bacteriocins; D008937:Mitomycins; D016685:Mitomycin