The destruction of factor VIII clotting activity by thrombin and plasmin.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D005169:Factor VIII; D005341:Fibrinolysin / Q000494:pharmacology*; D006801:Humans; D010958:Plasminogen / Q000494:pharmacology; D013300:Streptokinase / Q000494:pharmacology; D013552:Swine; D013917:Thrombin / Q000494:pharmacology*
D005169:Factor VIII; D010958:Plasminogen; D013300:Streptokinase; D013917:Thrombin; D005341:Fibrinolysin