Urokinase-induced fibrin clot lysis and its inhibition by plasma.
The kinetics of the urokinase-induced plasmin digestion of fibrin clots has been studied. Some theoretical aspects on the kinetics of the underlying enzyme reactions are presented. It is shown that the clot-lysis time may be used to measure the relative amounts of fibrinolysis inhibitors in plasma.
D000933:Antifibrinolytic Agents / Q000097:blood; D010450:Endopeptidases / Q000494:pharmacology*; D005337:Fibrin / Q000378:metabolism; D005341:Fibrinolysin / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D013997:Time Factors; D014568:Urokinase-Type Plasminogen Activator / Q000494:pharmacology*
D000933:Antifibrinolytic Agents; D005337:Fibrin; D010450:Endopeptidases; D005341:Fibrinolysin; D014568:Urokinase-Type Plasminogen Activator