[Haemodynamics, coronary blood flow and myocardial metabolism in man: effects of sufentanil and fentanyl (author's transl)].
The effects of sufentanil (0.7 microgram/kg) and fentanyl (7 microgram/kg) on general and coronary haemodynamics and myocardial metabolism were studied in 6 and 9 patients without cardiovascular disease. Both drugs produced a slight reduction in heart rate, cardiac index and mean aortic pressure, whilst peripheral vascular resistance remained unchanged. There was a decrease in dp/dtmax and a slight increase in LVEDP suggesting minimal depression of myocardial contractility. Myocardial blood flow and myocardial oxygen uptake slightly decreased due to reduction in pressure-, volume- and frequency-load and dp/dtmax. With both drugs arterial concentrations of glucose, lactate, pyruvate and free fatty acids and their myocardial uptake did not change significantly. Clinically equi-anaesthetic doses of sufentanil and fentanyl produced almost identical effects on general and coronary haemodynamics. With regard to the cardiovascular actions sufentanil offers no advantage over fentanyl.
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002318:Cardiovascular Diseases / Q000503:physiopathology; D003326:Coronary Circulation / Q000187:drug effects*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007773:Lactates / Q000097:blood; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen / Q000378:metabolism; D011773:Pyruvates / Q000097:blood; D017409:Sufentanil
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D011773:Pyruvates; D017409:Sufentanil; D010100:Oxygen; D005283:Fentanyl
Die Wirkungen von Sufentanil und Fentanyl auf Hämodynamik, Coronardurchblutung und myocardialen Metabolismus des Menschen.