title: Differential effects of pure human alpha and gamma interferons on fibroblast cell growth and the cell cycle.
abstract: Pure human alpha and recombinant gamma interferons had differential effects on two strains of fetal lung fibroblasts in vitro. Alpha interferon had little effect on long-term cell growth, whereas gamma interferons, both glycosylated and non-glycosylated, were cytotoxic. However, when synchronized cells were studied, alpha interferon prolonged both G1 and S + G2 phases of the cell cycle, whereas gamma interferon only affected the G1 phase.
mesh_terms: D002453:Cell Cycle / Q000187:drug effects*; D002478:Cells, Cultured; D005347:Fibroblasts; D005434:Flow Cytometry; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007371:Interferon-gamma / Q000494:pharmacology*; D007399:Interphase / Q000187:drug effects; D008168:Lung; D008938:Mitosis / Q000187:drug effects
chemical_list: D007370:Interferon Type I; D007371:Interferon-gamma