Genotoxic effects of dioxolane and trioxane in mice evaluated by the micronucleus test.
The possible genotoxic effects of dioxolane and trioxane were studied using the micronucleus test. Mice were given dioxolane and trioxane i.p. in two doses at 24-h intervals. Dioxolane at doses from 1500 mg/kg to 6000 mg/kg caused a significant increase of micronucleated polychromatic erythrocytes in bone marrow of mice as compared to the negative control value. Positive results in the micronucleus test provide evidence of genotoxic activity of dioxolane. I.p. administration of trioxane produced no chromosomal damage resulting in erythrocyte micronucleus formation, even at highly toxic doses.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D002467:Cell Nucleus / Q000187:drug effects*; D002875:Chromosomes / Q000187:drug effects*; D004148:Dioxolanes / Q000633:toxicity*; D004149:Dioxoles / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects* / Q000648:ultrastructure; D006571:Heterocyclic Compounds / Q000633:toxicity*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D016685:Mitomycin; D008937:Mitomycins / Q000633:toxicity
D004148:Dioxolanes; D004149:Dioxoles; D006571:Heterocyclic Compounds; D008937:Mitomycins; C011374:s-trioxane; D016685:Mitomycin; C010962:formal glycol