Different fate of antibodies to surface IgM and IgD in germinal centre cell-associated lymphomas.
In all of four human germinal centre cell-associated B lymphomas carrying sIgM + sIgD F(ab')2 fragments of rabbit antibodies to human mu-chain were accumulated intracellularly, whereas the accumulation of antibodies to delta-chain was considerably less abundant. The accumulation of antibodies to light chain was intermediate between antibodies to mu- and delta-chain. These results could be explained by the following observations: (i) the difference in the level of reexpression of sIgM and sIgD and (ii) the discovery that antibodies to delta-chain bound to reexpressed sIgD were degraded at a higher rate than those bound to primary sIgD and at a higher rate than antibodies to mu-chain, whether bound to primary or reexpressed sIgM.
D000042:Absorption; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis* / Q000502:physiology; D001666:Binding Sites, Antibody; D002478:Cells, Cultured; D006801:Humans; D007072:Immunoglobulin D / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology*; D007138:Immunoglobulin delta-Chains / Q000276:immunology; D007148:Immunoglobulin mu-Chains / Q000276:immunology; D007700:Kinetics; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D008223:Lymphoma / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000276:immunology* / Q000378:metabolism
D000888:Antibodies, Anti-Idiotypic; D007072:Immunoglobulin D; D007075:Immunoglobulin M; D007138:Immunoglobulin delta-Chains; D007148:Immunoglobulin mu-Chains; D011947:Receptors, Antigen, B-Cell