Anti-aggressive effect of zimelidine in isolated mice.
The anti-aggressive actions of zimelidine, a 5-HT uptake inhibitor, and p-chloroamphetamine (PCA), a 5-HT releasing compound, were examined in isolated male mice. Both agents blocked the aggressive behaviour in a dose range in which they produced inhibition of the accumulation of 14C-5-HT in brain slices. The time course of the inhibition of both compounds was related to their effects on 5-HT mechanisms (5-HT uptake inhibition or 5-HT release) in the brain. These findings suggest that zimelidine and PCA inhibit aggressive behaviour in mice via enhancement of post-synaptic activity in certain 5-HT neuronal pathways. The possible relationship between the role of 5-HT in the anti-aggressive effect and in anxiolytic effects is discussed.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001977:Brompheniramine / Q000031:analogs & derivatives / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000378:metabolism; D011725:Pyridines / Q000494:pharmacology*; D012701:Serotonin / Q000378:metabolism; D013997:Time Factors; D015031:Zimeldine; D010133:p-Chloroamphetamine / Q000494:pharmacology
D000928:Antidepressive Agents; D011725:Pyridines; D012701:Serotonin; D015031:Zimeldine; D010133:p-Chloroamphetamine; D001977:Brompheniramine; D009638:Norepinephrine