Urticaria pigmentosa treated with oral disodium cromoglycate.
4 patients with urticaria pigmentosa were treated with oral disodium cromoglycate (DSCG) for 2 months. During the treatment urine excretion of the main histamine metabolite, 1,4-methylimidazoleacetic acid (MIAA), was determined, and sequential skin biopsies were examined. DSCG was found to have beneficial effect on pruritus and whealing in 3 patients. The one treatment failure was in a patient without pruritus. The skin lesions remained unchanged. DSCG treatment had no effect on MIAA excretion or on the number of mast cells found in the skin biopsies.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D004205:Cromolyn Sodium / Q000008:administration & dosage*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000652:urine; D008297:Male; D008407:Mast Cells / Q000473:pathology; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D013997:Time Factors; D014582:Urticaria Pigmentosa / Q000188:drug therapy* / Q000473:pathology / Q000652:urine
D007093:Imidazoles; C002667:methylimidazoleacetic acid; D004205:Cromolyn Sodium