Functional residual lung capacity in rats affected by a carotid body stimulant.
The respiratory response and changes of functional residual lung capacity were measured in the rat after intravenous administration of the drug S 2620 in a dose of 0.4 mg/kg. This substance induced a significant decrease of arterial PCO2 and an increase of minute ventilation. The stimulating effect of S 2620 was maximal in the 10th min; after 60 min, ventilation and PCO2 approached control levels. The CO2 ventilatory response was determined 10 min after the administration of S 2620. The slope of the control and S 2620 stimulated curves was similar with a shift towards higher ventilation and lower PCO2 after S 2620 administration. Functional capacity rose with increasing minute ventilation. The increase of functional residual capacity disappeared after bilateral cervical vagotomy.
D015765:Almitrine; D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D002344:Carotid Body / Q000187:drug effects*; D005652:Functional Residual Capacity; D007275:Injections, Intravenous; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012115:Residual Volume; D012119:Respiration / Q000187:drug effects*; D013990:Tidal Volume; D013997:Time Factors
D010879:Piperazines; D002245:Carbon Dioxide; D015765:Almitrine