Synergistic effect of subteratogenic doses of antisera on the development in the rat.
Wistar rats were administered rabbit anti-rat-umbilical-cord serum (AUCS) alone on day 9 of gestation or in combination with subteratogenic doses of rabbit anti-rat-kidney serum (AKS). The results showed that the incidence of malformation was low (13.1% +/- 7.0 S.E.) even when very high doses of AUCS alone were administered. However, the incidence markedly increased to 61.0% +/- 9.3 S.E. when a small dose (0.10 ml/100 gm) of AKS was administered on day 9 followed by 0.90 ml/100 gm of AUCS on day 10. The malformations included microphthalmia, hydrocephaly, aortic arch anomalies, ventricular septal defect, and anophthalmia, being similar to the effects of a medium dose of AKS. These results suggest that a combination of subteratogenic doses of teratogenic antisera produces malformations, possibly by mechanisms that potentiate the teratogenic action of the sera.
D000014:Abnormalities, Drug-Induced / Q000145:classification / Q000453:epidemiology*; D000818:Animals; D000906:Antibodies / Q000032:analysis; D004357:Drug Synergism; D005260:Female; D005455:Fluorescent Antibody Technique; D007106:Immune Sera / Q000008:administration & dosage* / Q000494:pharmacology; D005779:Immunodiffusion; D007668:Kidney / Q000276:immunology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D014470:Umbilical Cord / Q000276:immunology*; D015017:Yolk Sac / Q000276:immunology
D000906:Antibodies; D007106:Immune Sera