title: Synthesis of new 4 and 5 disubstituted isothiazoles.
abstract: Synthesis of 24 new 4 and 5 substituted isothiazole derivatives, containing hydrazine and amino groups at the position 5, and carboxyl, ester, amide, hydrazide, nitrile or ureido group in the position 4 is described. Compounds 4, 6, 8 and 19 show antiinflammatory activity, compound 14 has antiaggregatory properties.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D011817:Rabbits; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D000998:Antiviral Agents; D013844:Thiazoles