Properties of bovine interferons.
This study was done in an attempt to elucidate some of the properties of bovine IFNs. Maximum levels of both fibroblast and leukocyte IFNs occurred prior to 24 h whereas maximum levels of immune IFN were not reached until after 72 h. The latter species of IFN was unstable at either pH 2 or 56 degrees C whereas both the fibroblast and leukocyte IFNs were more stable under these conditions. Studies of cross-species protection between fibroblast and leukocyte IFNs indicate that the former was more protective for other species than the latter.
D000818:Animals; D002417:Cattle; D002460:Cell Line; D003208:Concanavalin A / Q000494:pharmacology; D004355:Drug Stability; D004622:Embryo, Mammalian; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D007370:Interferon Type I / Q000096:biosynthesis*; D007371:Interferon-gamma / Q000096:biosynthesis*; D007668:Kidney; D007700:Kinetics; D007962:Leukocytes / Q000378:metabolism; D009522:Newcastle disease virus / Q000502:physiology; D010835:Phytohemagglutinins / Q000494:pharmacology; D014132:Trachea; D014420:Turbinates
D007370:Interferon Type I; D010835:Phytohemagglutinins; D003208:Concanavalin A; D007371:Interferon-gamma