Phospholipid and glyceride biosynthesis in 2,4,5,2',4',5'-hexachlorobiphenyl-treated human skin fibroblasts.
2,4,5,2',4',5'-Hexachlorobiphenyl (HCB) was taken up by cultured human skin fibroblasts ( A61437 ; GM488 ). HCB caused enhanced incorporation of [2-14C]acetate into phospholipids and glycerides at low concentration and reduced incorporation at high concentrations. sn-[U-14C]Glycerol-3-phosphate incorporation into phospholipids was inhibited. No significant change in total cellular phospholipids was observed. Triglyceride cellular content was increased 29%. The observed stimulation and inhibition of phosphoglyceride synthesis are similar to results obtained with rat liver microsomes.
D002478:Cells, Cultured; D000431:Ethanol / Q000494:pharmacology; D005347:Fibroblasts / Q000378:metabolism; D005989:Glycerides / Q000096:biosynthesis*; D006801:Humans; D010743:Phospholipids / Q000096:biosynthesis*; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D012867:Skin / Q000378:metabolism
D005989:Glycerides; D010743:Phospholipids; D000431:Ethanol; D011078:Polychlorinated Biphenyls; C014024:2,4,5,2',4',5'-hexachlorobiphenyl