The influence of PAF on the metabolization of arachidonic acid by human blood platelets.
The cooperative action of PAF and arachidonic acid, collagen or the divalent cation ionophore A 23 187 was studied in human platelet-rich plasma. Besides an augmentation of the platelet aggregation also increased amounts of thromboxane B2 and malondialdehyde are generated. Both effects are inhibited by aspirin indicating that the cyclooxygenase pathway plays a major role in the synergistic platelet activation.
D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000097:blood*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D000001:Calcimycin / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008315:Malondialdehyde / Q000097:blood; D010972:Platelet Activating Factor / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D013929:Thromboxane B2 / Q000097:blood
D001095:Arachidonic Acids; D010972:Platelet Activating Factor; D016718:Arachidonic Acid; D000001:Calcimycin; D008315:Malondialdehyde; D013929:Thromboxane B2; D003094:Collagen