Coagulation factors V and VIII and ceruloplasmin constitute a family of structurally related proteins.
Computer searches of the National Biomedical Research Foundation protein and nucleic acid sequence data bases using the NH2 terminus of the bovine factor Va 94-kilodalton heavy chain, the NH2 terminus of the 74-kilodalton factor Va light chain, and an internal 98-residue segment of porcine factor VIII revealed that both bovine factor V and porcine factor VIII are statistically homologous to human ceruloplasmin. The NH2-terminal segment of bovine factor Va heavy chain is homologous to three segments of ceruloplasmin sequence starting at residues 1, 351, and 713; the NH2-terminal sequence of bovine factor Va light chain is homologous to the same human ceruloplasmin sequence segments beginning at residues 1, 349, and 711. The longer porcine factor VIII sequence is homologous to three segments of human ceruloplasmin, residues 1-77, 400-433, and 683-791. These data indicate that factor V, factor VIII, and ceruloplasmin comprise a group of evolutionarily linked protein structures that possibly resulted from multiplication of ancestral precursor genes.
D000595:Amino Acid Sequence; D005075:Biological Evolution; D002570:Ceruloplasmin / Q000235:genetics*; D005165:Factor V / Q000235:genetics*; D005169:Factor VIII / Q000235:genetics*; D006801:Humans
D005165:Factor V; D005169:Factor VIII; D002570:Ceruloplasmin