title: Effect of dietary methionine and lysine on the toxicity of ingested lead acetate in the chick.
abstract: The interaction of methionine or lysine with lead in the diet of chicks was studied. In experiment 1, lead acetate to supply 0 or 1000 ppm lead was added to a diet that was either deficient in the total sulfur-containing amino acid (TSAA) content (62% of the requirement) or supplemented with DL-methionine to provide 100% of the requirement (NRC, 1977). Supplementing the 0 ppm lead diet with methionine improved body weight gain. Dietary addition of 1000 ppm lead significantly decreased body weight gain; however, supplemental methionine partially alleviated the lead-induced growth depression (methionine X lead interaction was significant). Liver glutathione levels were markedly increased by supplemental methionine and also by lead but no methionine X lead interaction was detected. In experiment 2, the interaction between an essential non-sulfur-containing amino acid, lysine, and dietary lead was investigated. Two levels of lead, 0 or 1000 ppm, were fed in diets either deficient or adequate in lysine (85 or 100% of the requirement, respectively). Addition of lysine to the lysine-deficient basal diet increased growth. The magnitude of the lead-induced growth depression was not affected by dietary lysine content. The lysine level of the diet did not influence the liver glutathione concentration.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002645:Chickens; D004032:Diet; D005978:Glutathione / Q000378:metabolism; D006128:Growth / Q000187:drug effects; D007854:Lead / Q000633:toxicity*; D008099:Liver / Q000378:metabolism; D008239:Lysine / Q000172:deficiency / Q000502:physiology*; D008297:Male; D008715:Methionine / Q000172:deficiency / Q000502:physiology*; D009942:Organometallic Compounds
chemical_list: D009942:Organometallic Compounds; D007854:Lead; D008715:Methionine; D005978:Glutathione; D008239:Lysine; C008261:lead acetate