title: Respiratory infection of cyclophosphamide-treated mice with Pseudomonas aeruginosa.
abstract: The dose of cyclophosphamide that permits the colonization of the nasopharynx with Pseudomonas aeruginosa and the survival of the animal was determined in mice. This dose, 100 mg/kg of cyclophosphamide, allowed P aeruginosa to colonize but not invade mouse nasal epithelium. Mice treated with 100 mg/kg cyclophosphamide were exposed to aerosol of 35S-labeled P aeruginosa to study clearance. Results indicated that this dose of cyclophosphamide suppressed both the pulmonary clearance of viable P aeruginosa (in situ killing) and the clearance of radiolabeled P aeruginosa (mechanical clearance).
mesh_terms: D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology*; D005260:Female; D008168:Lung / Q000382:microbiology / Q000503:physiopathology; D008297:Male; D051379:Mice; D009305:Nasopharynx / Q000382:microbiology; D011552:Pseudomonas Infections / Q000503:physiopathology*; D011550:Pseudomonas aeruginosa; D012141:Respiratory Tract Infections / Q000382:microbiology / Q000503:physiopathology*
chemical_list: D003520:Cyclophosphamide