beta-Mannosidase in human leukocytes and fibroblasts.
In human leukocytes and fibroblasts beta-mannosidase activity has a unimodal pH optimum (4.0-4.5). Markedly reduced activity is found in I-cell disease. Normal activities in human fibroblasts are ten times higher than in the goat, in which species a deficiency disease has been described.
D000818:Animals; D002478:Cells, Cultured; D005347:Fibroblasts / Q000201:enzymology*; D006041:Goats / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007962:Leukocytes / Q000201:enzymology*; D008361:Mannosidases / Q000172:deficiency / Q000378:metabolism*; D012867:Skin / Q000166:cytology; D008363:alpha-Mannosidosis / Q000378:metabolism / Q000662:veterinary*; D044902:beta-Mannosidase
D008361:Mannosidases; D044902:beta-Mannosidase