Effects of steroid hormones and xenobiotics on the pubertal development of UDP-glucuronosyltransferase activities towards androsterone and 4-nitrophenol in Wistar rats.
Oestradiol benzoate, testosterone propionate, progesterone, corticosterone, 3-methylcholanthrene and phenobarbital were administered to Wistar rats at the pubertal period, and their effects on hepatic UDP-glucuronosyltransferase activities were determined. Pretreatment with oestradiol benzoate had a temporary suppressive effect on androsterone UDP-glucuronosyltransferase activity in rats with the high-activity phenotype of androsterone glucuronidation. The effect was marked in 40-day-old rats, but was not found in older rats. Androsterone UDP-glucuronosyltransferase activity was induced by phenobarbital in rats with the high-activity phenotype, but not in rats with the low-activity phenotype. Foster-feeding experiments showed that breast milk did not alter the genetically determined expression of androsterone UDP-glucuronosyltransferase activity in Wistar rats. In contrast, 4-nitrophenol UDP-glucuronosyltransferase activity was not affected by steroid hormones, but was highly induced by 3-methylcholanthrene.
D000738:Androsterone / Q000378:metabolism*; D000818:Animals; D003345:Corticosterone / Q000494:pharmacology; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D014453:Glucuronosyltransferase / Q000378:metabolism*; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008892:Milk / Q000502:physiology; D009596:Nitrophenols / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology; D010641:Phenotype; D051381:Rats; D011919:Rats, Inbred Strains; D012741:Sexual Maturation / Q000187:drug effects
D012739:Gonadal Steroid Hormones; D009596:Nitrophenols; D004958:Estradiol; D008748:Methylcholanthrene; D000738:Androsterone; D014453:Glucuronosyltransferase; D003345:Corticosterone; C024836:4-nitrophenol; D010634:Phenobarbital