Serotoninergic mechanisms of beta-endorphin- and clonidine-induced analgesia in rats.
Both beta-endorphin and clonidine proved to have statistically significant analgesic activity (increase in latency to hind-paw lick in hot plate test) in rats. Furthermore, the pain inhibition induced by beta-endorphin and clonidine could be antagonized by prior treatment of animals with either naloxone (a narcotic antagonist) or the depletors of central serotonin pathways such as 5,6-dihydroxytryptamine, 5,7-dihydroxytryptamine and p-chlorophenylalanine have not effect on latency to hind-paw lick. The data indicate that serotoninergic activity in the brain plays a role in the elaboration or modulation of beta-endorphin and clonidine analgesia in rats.
D015115:5,6-Dihydroxytryptamine / Q000494:pharmacology; D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000698:Analgesia; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D003000:Clonidine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004723:Endorphins / Q000494:pharmacology*; D010134:Fenclonine / Q000494:pharmacology; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000032:analysis
D004723:Endorphins; D011985:Receptors, Serotonin; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D009270:Naloxone; D003000:Clonidine; D010134:Fenclonine; D015115:5,6-Dihydroxytryptamine