[Demonstration in human plasma of 2 factors inhibiting hepatocyte multiplication by blocking the cell cycle at the level of G1-S transition].
A factor which inhibits the G1-S transition of synchronized proliferating hepatocytes is detected in human serum or plasma. This activity is associated with an electronegatively charged component of high molecular weight in the native serum. Serum and plasma submitted to trypsin hydrolysis or to liver microsomes, release an ultrafiltrable component of low molecular weight which displays the same activity as the high molecular weight one from the native serum. This inhibitory system of hepatocyte proliferation is similar to that already described in Rat serum. It is species independent.
D000328:Adult; D000818:Animals; D006131:Growth Inhibitors / Q000097:blood* / Q000494:pharmacology; D006801:Humans; D007399:Interphase / Q000187:drug effects*; D008099:Liver / Q000166:cytology*; D008970:Molecular Weight; D051381:Rats
D006131:Growth Inhibitors
Mise en évidence dans le plasma humain de deux facteurs inhibiteurs de la multiplication des hépatocytes par blocage du cycle cellulaire au niveau de la transition G1-S.