[Hypoglycemic effects of the blended Chinese traditional medicines in genetically and chemically diabetic mice].
The selective sensitivities to the blended Chinese traditional medicines (Kampo Hozai) applied for diabetes mellitus were pharmacologically studied utilizing the diabetic models: genetically diabetic KK-CAy mice and alloxan diabetic mice. The hypoglycemic response to sulfonylurea (tolbutamide) was observed in the KK-CAy mice as well as that to metformin, giving evidence which supported the difference of diabetic features between KK-CAy mice and alloxan diabetic mice. The hypoglycemic potencies of the blended medicines were determined in alloxan diabetics: Chikuyosekkoto greater than Byakkoka-Ninjinto not equal to Bakumondoto much greater than Hachimigan not equal to Ninjinto greater than Goreisan. A similar order of potency was shown in the fasted KK-CAy mice. In the nonfasted KK-CAy mice, Hachimigan selectively had the more marked hypoglycemic effect. In conclusion, it is compatible that the effects of Kampo Hozai may be classified into plural types of action mechanism by utilizing etiologically different diabetic models.
D000496:Alloxan; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000235:genetics; D005905:Glyburide / Q000627:therapeutic use; D007004:Hypoglycemic Agents; D008297:Male; D008516:Medicine, Chinese Traditional; D008518:Medicine, East Asian Traditional; D008687:Metformin / Q000627:therapeutic use; D051379:Mice; D014044:Tolbutamide / Q000627:therapeutic use
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D000496:Alloxan; D008687:Metformin; D014044:Tolbutamide; D005905:Glyburide