title: [Therapy of atopic eczema].
abstract: When a decision is being made on the therapy of atopic eczema, the complex pathogenetic interactions involved in this disease have to be taken into consideration. The acute inflammatory changes respond to short-term glucocorticoid steroid treatment (topical); long-term steroid therapy should be avoided. In chronic lichen-type lesions, non-steroid topical applications can be helpful. Frequent acute infections of the skin require the application of antimicrobials. Intense pruritus is treated by antihistamines (possibly also H2-antagonists). Due to the well-known psychosomatic influence in this disease, careful counseling of the patient (and if a child, of the family) is necessary. Pathogenetically relevant allergic reactions of the immediate type can be treated successfully in some cases by hyposensitization. Prophylactic measures include allergen avoidance (climate therapy, no pets, well-established food allergens etc.). Possible new perspectives may be seen in the development of agents acting at the disturbed T-cell regulation, as well as by the introduction of mast-cell-blocking substances. The basis of every therapeutic approach in atopic eczema is, however, intensive skin care, using emollients and oil baths, especially during the remission phase.
mesh_terms: D000287:Administration, Topical; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003876:Dermatitis, Atopic / Q000175:diagnosis / Q000188:drug therapy* / Q000276:immunology; D005938:Glucocorticoids; D006633:Histamine Antagonists / Q000627:therapeutic use; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007073:Immunoglobulin E / Q000378:metabolism; D007978:Levamisole / Q000627:therapeutic use; D008134:Long-Term Care; D008407:Mast Cells / Q000187:drug effects; D011537:Pruritus / Q000188:drug therapy; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D000900:Anti-Bacterial Agents; D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D006633:Histamine Antagonists; D007978:Levamisole; D007073:Immunoglobulin E
vernacular_title: Zur Therapie des atopischen Ekzems.