title: Storage of mixtures for total parenteral nutrition. II. Microbiological control of large volume TPN mixtures.
abstract: Microbiological control of TPN mixtures can be performed either by controlling the aseptic filling procedure using culture medium instead of intravenous solutions, or by an end-product sterility test. A microbiological process control of the filling procedure is described, and it is shown that a hospital pharmacy can prepare 3-litre bags without contamination. The number of 3-litre bags necessary in the process control is discussed, as well as the frequency with which a control should be performed. A possible non-destructive system for testing each 3-litre bag microbiologically is outlined and discussed. This system may be used when TPN mixtures without lipid emulsion are stored for longer periods.
mesh_terms: D003470:Culture Media; D004349:Drug Packaging; D004356:Drug Storage; D005506:Food Contamination / Q000517:prevention & control*; D005516:Food Microbiology; D006801:Humans; D010288:Parenteral Nutrition; D010289:Parenteral Nutrition, Total; D013242:Sterilization; D014462:Ultrafiltration
chemical_list: D003470:Culture Media