99mTc-labelled compounds prepared with molybdenum III as reducing agent.
The experiment of labelling DTPA, HEDSPA and gluconate revealed that it is also possible to make successful use of Mo(III) to reduce pertechnetate in solution of pH 5.5. 99mTc after i.v. administration of [99mTc]Mo-DTPA is quickly removed from the organism without any more remarkable cumulation being manifested in any one of the organs; after administration of [99mTc]Mo-HEDSPA it is cumulated in bones (42% in 1 h). During gluconate labelling two types of technetium complexes are formed depending upon the duration of pertechnetate reduction. Complex I is formed during 1-3 min reduction, giving, in biological experiments, 20% of applied 99mTc activity within 2 h in kidneys. Complex II, which is formed after 45 min reduction, loses its affinity towards kidneys, being cumulated in bones (12% in 2 h).
D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging; D012968:Etidronic Acid; D005942:Gluconates; D007553:Isotope Labeling / Q000379:methods; D008982:Molybdenum; D015609:Organotechnetium Compounds; D004369:Pentetic Acid; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium; D016284:Technetium Tc 99m Pentetate; D014018:Tissue Distribution
D005942:Gluconates; D015609:Organotechnetium Compounds; C032080:technetium Tc 99m gluconate; C019561:technetium Tc 99m etidronate; D013667:Technetium; D004369:Pentetic Acid; D008982:Molybdenum; D012968:Etidronic Acid; D016284:Technetium Tc 99m Pentetate