The anticonvulsant effect of the benzodiazepine antagonist, Ro 15-1788: an EEG study in 4 cases.
An EEG study was carried out in 4 epileptic patients. In each case, Ro 15-1788 caused the disappearance or marked reduction of the epileptic potentials. In 1 case the patient had been pretreated with diazepam; in the other cases there had been no prior benzodiazepine treatment. In the first case, it is possible that Ro 15-1788 acted by abolishing a paradoxical effect of diazepam; in the other cases, we postulate an intrinsic anticonvulsant effect of Ro 15-1788. This investigation would suggest further study of Ro 15-1788 in epileptic patients for clarification of its anticonvulsant properties. In addition, evaluation of its action on the sedation caused by benzodiazepine antiepileptic medication is suggested.
D000200:Action Potentials / Q000187:drug effects; D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D001569:Benzodiazepines / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D001570:Benzodiazepinones / Q000008:administration & dosage / Q000627:therapeutic use*; D004347:Drug Interactions; D004569:Electroencephalography; D004830:Epilepsy, Tonic-Clonic / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D005442:Flumazenil; D006801:Humans; D008297:Male
D000927:Anticonvulsants; D001570:Benzodiazepinones; D001569:Benzodiazepines; D005442:Flumazenil