Effect of experimentally induced diabetes on swine vascular prostacyclin (PGI2) synthesis.
Repeated administration of streptozotocin to Göttingen miniature swine led to the development of a mild form of diabetes. The amount of PGI2 generated by the vessels (abdominal aorta, thoracic aorta, pulmonary artery), as estimated by reference to inhibition of ADP-induced platelet aggregation, was lower in the treated animals than in the controls. The decrease in the synthesis of PGI2 may contribute to the prethrombotic state in diabetes mellitus.
D000818:Animals; D001012:Aorta, Abdominal; D001013:Aorta, Thoracic; D001786:Blood Glucose; D003921:Diabetes Mellitus, Experimental / Q000097:blood*; D011464:Epoprostenol / Q000096:biosynthesis*; D007328:Insulin / Q000276:immunology; D010179:Pancreas / Q000032:analysis; D011453:Prostaglandins / Q000096:biosynthesis*; D011651:Pulmonary Artery; D013311:Streptozocin; D013552:Swine
D001786:Blood Glucose; D007328:Insulin; D011453:Prostaglandins; D013311:Streptozocin; D011464:Epoprostenol