Induction of human gamma interferon by Sarcophaga peregrina humoral lectin.
Humoral lectin isolated from the hemolymph of injured Sarcophaga peregrina (flesh-fly) larvae was found to activate human peripheral blood cells to produce interferon activity. This interferon was inactivated by dialysis against a solution of pH 2.0 and by heat treatment at 56 degrees C for 30 min, indicating that it was a gamma interferon. The role of this lectin in the defence mechanism is discussed from the viewpoint of comparative immunology.
D000818:Animals; D004175:Diptera; D006801:Humans; D019476:Insect Proteins; D007369:Interferon Inducers / Q000302:isolation & purification*; D007371:Interferon-gamma / Q000096:biosynthesis*; D007700:Kinetics; D007814:Larva; D037102:Lectins / Q000302:isolation & purification* / Q000494:pharmacology; D037181:Lectins, C-Type; D007962:Leukocytes / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
C043030:20kDa lectin protein, Sarcophaga; D019476:Insect Proteins; D007369:Interferon Inducers; D037102:Lectins; D037181:Lectins, C-Type; D007371:Interferon-gamma