Ibuprofen in the prevention of experimentally induced postoperative adhesions.
Using a five-dose 70 mg/kg regimen, of ibuprofen significantly reduced both overall adhesion formation and the severity of adhesions when given to rabbits in the immediate postoperative period. This reduction was apparently time- and dose-related, as animals given smaller doses of ibuprofen at subsequent intervals had a tendency toward more adhesions and also more severe adhesions. A positive correlation was found between the severity of adhesions and the formation of new glycosaminoglycans and collagens.
D000005:Abdomen / Q000601:surgery; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism; D003094:Collagen / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D006025:Glycosaminoglycans / Q000378:metabolism; D007052:Ibuprofen / Q000008:administration & dosage / Q000627:therapeutic use*; D007249:Inflammation / Q000150:complications; D011182:Postoperative Care; D011183:Postoperative Complications / Q000517:prevention & control*; D011817:Rabbits; D013997:Time Factors; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control*; D014945:Wound Healing
D001095:Arachidonic Acids; D006025:Glycosaminoglycans; D016718:Arachidonic Acid; D003094:Collagen; D007052:Ibuprofen