Lung and heart-lung transplantation.
This report is a brief summary on current events related to lung and heart-lung transplantation. Eleven patients have undergone transplantation of the heart and both lungs at Stanford University. The ages ranged from 22-45, the average age being about 36 years, and included were four females and seven males. The diagnosis was primary pulmonary hypertension in three and Eisenmenger syndrome--congenital heart disease with pulmonary hypertension--in eight. Eight patients are living and well, two to more than 24 months after transplantation of the heart and both lungs. All these patients were discharged and are fully rehabilitated, which is an important consideration. There have been three operative deaths, one was secondary to two previous operations that made our operation much too long, another was secondary to the use of intravenous cyclosporine, and the third was related to the poor maintenance of the donor lung. Three of the eleven patients were catheterized following the transplant from six months to a year after transplantation, and the pulmonary artery pressure and pulmonary vascular resistance were absolutely normal in all three of these individuals. Of course the plan is to go ahead with further catheter studies at yearly intervals in all of the patients. The last patient underwent transplantation in January, 1983. I think no matter how effective or how ingenious the medical staff is with artificial organs, it will be a long time before these early results of transplantation of the heart and both lungs can be matched by any types of artificial organ implants.
D000328:Adult; D000818:Animals; D001379:Azathioprine / Q000494:pharmacology; D003524:Cyclosporins / Q000494:pharmacology; D004285:Dogs; D004541:Eisenmenger Complex / Q000601:surgery; D005260:Female; D006084:Graft Rejection / Q000187:drug effects; D016027:Heart Transplantation; D016041:Heart-Lung Transplantation; D006801:Humans; D006976:Hypertension, Pulmonary / Q000601:surgery; D007165:Immunosuppression Therapy; D016040:Lung Transplantation; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008297:Male; D008875:Middle Aged; D011817:Rabbits
D003524:Cyclosporins; D001379:Azathioprine