Gonadotropin secretion in hyperthyroidism and hypothyroidism.
Gonadotropin patterns were evaluated in a group of 70 patients of both sexes with Graves' disease or primary hypothyroidism. Significant variations were found only in hyperthyroidism where increased basal and stimulated values of both gonadotropins, but particularly LH, occurred. Qualitative and quantitative recovery was seen when euthyroid states were achieved after treatment of hyper- and hypothyroid patients. Interactions with gonadotropin behavior were found in both sexes and in women of different ages. Direct interference on the hypothalamo-pituitary system rather than through the modulation of peripheral estrogen metabolism is suggested as the possible pathogenetic mechanism.
D000328:Adult; D000368:Aged; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006065:Gonadotropins, Pituitary / Q000378:metabolism*; D006111:Graves Disease / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000503:physiopathology*; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D008593:Menopause; D008875:Middle Aged; D011863:Radioimmunoassay; D013972:Thyrotropin / Q000502:physiology; D013974:Thyroxine / Q000502:physiology; D014284:Triiodothyronine / Q000502:physiology
D006065:Gonadotropins, Pituitary; D014284:Triiodothyronine; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013974:Thyroxine