title: The effects on wound healing of three amino acids--a comparison of two models.
abstract: We have utilized two different models to evaluate the role of the amino acids L-cysteine, glycine and DL-threonine in wound healing. Both studies used a double-blind, placebo-controlled, randomized treatment plan. The first model involved the use of blister bases created on human forearm skin by the ammonium hydroxide technique, whilst the second model was that of hypostatic leg ulceration. We conclude that the amino acids did not contribute to the healing of blister bases but that they were of benefit in hypostatic leg ulceration.
mesh_terms: D000328:Adult; D000368:Aged; D001414:Bacitracin / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003545:Cysteine / Q000627:therapeutic use; D004311:Double-Blind Method; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D005998:Glycine / Q000627:therapeutic use; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D009355:Neomycin / Q000627:therapeutic use; D013912:Threonine / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D004338:Drug Combinations; C042351:bacitracin, cysteine, glycine, neomycin, threonine drug combination; D001414:Bacitracin; D013912:Threonine; D009355:Neomycin; D003545:Cysteine; D005998:Glycine