Sulfur amino acid metabolism in juvenile-onset nonketotic and ketotic diabetic patients.
Sulfur amino acid metabolism was studied in non-fasting nonketotic and ketotic juvenile-onset diabetic children and the results were compared to age-matched healthy children on an ordinary diet. An increased excretion of total sulfur and inorganic sulfate was found in diabetic children, probably a result of a decreased protein-serum synthesis and/or increased endogenous protein catabolism, although as a result of hyperglycemia a decreased tubular reabsorption may also have contributed. All diabetics showed a normal excretion of methionine. For cyst(e)ine and taurine an increased excretion was seen in ketotic diabetics, probably also a consequence of an increased endogenous protein degradation. As a sign of the latter, an increased output of 3-methylhistidine was also observed, a confirmation of earlier reports. The increased output of mercaptolactate and mercaptoacetate found in ketotic patients, was probably also a result of enhanced endogenous protein degradation. An increased urinary excretion of N-acetylcysteine was seen in diabetic children, which may reflect an enhanced availability to acetyl coenzyme A.
D000293:Adolescent; D000603:Amino Acids, Sulfur / Q000378:metabolism* / Q000652:urine; D002648:Child; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism* / Q000652:urine; D016883:Diabetic Ketoacidosis / Q000378:metabolism* / Q000652:urine; D004952:Esters / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D010710:Phosphates / Q000097:blood / Q000652:urine; D013431:Sulfates / Q000097:blood / Q000652:urine; D013455:Sulfur / Q000652:urine
D000603:Amino Acids, Sulfur; D004952:Esters; D010710:Phosphates; D013431:Sulfates; D013455:Sulfur