[Comparative study of the vasoreactivity of isolated human cortical and juxtamedullary glomeruli using verapamil and dopamine].
The purpose of the present study was to compare the area variations of human cortical and juxtamedullary glomeruli after incubation with verapamil and dopamine. The glomeruli were isolated by sieving; areas were measured by a video analyser. The surface of the cortical glomeruli increases largely with verapamil (+14,3%) and dopamine (+11,5%). But, the area of the juxtamedullary glomeruli remains unchanged in the same experimental conditions. Evidence of such a vasoreactivity difference between cortical and juxtamedullary glomeruli will permit a better understanding in the regulation of renal haemodynamics.
D004298:Dopamine / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007672:Kidney Cortex; D007678:Kidney Glomerulus / Q000098:blood supply* / Q000648:ultrastructure; D007679:Kidney Medulla; D014664:Vasodilation / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil; D004298:Dopamine
Etude comparée de la vasoréactivité des glomérules isolés superficiels et profonds d'origine humaine vis-à-vis du vérapamil et de la dopamine.