title: [An autopsy case of extramedullary plasmacytoma with systemic dissemination 2 years after the onset of a localized tumor in the nasal cavity].
abstract: A 73-year-old male was admitted because of a localized tumor in the nasal cavity, which was suspected to be malignant lymphoma by biopsy specimens. Laboratory findings were within normal limits except for small amounts of M protein (IgG-lambda) in the serum. The patient was successfully treated by radiotherapy, with the disappearance of both the tumor and M protein. Two years after the onset, however, a solid tumor was observed in the soft tissue, followed by rapid systemic dissemination. An increase in M protein was obvious, and the biopsy specimens disclosed plasmacytoma. The patient died three months after admission, and post-mortem examinations revealed a diffuse infiltration of plasmacytes predominantly in the soft tissues.
mesh_terms: D000368:Aged; D006023:Glycoproteins / Q000032:analysis; D006801:Humans; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D008207:Lymphatic Metastasis; D008297:Male; D009296:Nasal Cavity; D009669:Nose Neoplasms / Q000032:analysis / Q000473:pathology* / Q000532:radiotherapy; D010954:Plasmacytoma / Q000032:analysis / Q000473:pathology / Q000556:secondary*; D012983:Soft Tissue Neoplasms / Q000032:analysis / Q000473:pathology / Q000556:secondary*
chemical_list: D006023:Glycoproteins; D007146:Immunoglobulin lambda-Chains; C023587:protein M (glycoprotein)