Comparative study of piperacillin, ticarcillin, and carbenicillin pharmacokinetics.
Piperacillin, ticarcillin, and carbenicillin were administered intravenously to 10 healthy volunteers in a three-way, crossover study. The pharmacokinetics of the three drugs were in general quite similar. The peak serum concentration of piperacillin achieved at the end of a 30-min intravenous infusion was 63.5 +/- 27.6 microgram/ml. During the first 8 h, 67.5% of the dose of piperacillin was excreted in the urine, and the urinary concentration was extremely high. All three penicillins had high volumes of distribution. The serum half-life of the beta elimination phase of carbenicillin was lower than that of either piperacillin or ticarcillin. The volunteers experienced no adverse reactions from the administration of the drugs.
D000328:Adult; D001419:Bacteria / Q000187:drug effects; D002228:Carbenicillin / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010406:Penicillins / Q000097:blood / Q000378:metabolism* / Q000652:urine; D010878:Piperacillin; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013982:Ticarcillin / Q000097:blood / Q000378:metabolism* / Q000652:urine
D010406:Penicillins; D013982:Ticarcillin; D002228:Carbenicillin; D010878:Piperacillin