Effects of skin extract on sebaceous gland function in the rat.
The subcutaneous injection of a rat skin extract inhibits sebum excretion. The mitotic rate in the sebaceous glands is reduced. Therefore, a chalone of the sebaceous gland seems to exist. The regulation of sebum excretion is discussed.
D000818:Animals; D003703:Demecolcine / Q000494:pharmacology; D006131:Growth Inhibitors / Q000502:physiology; D008297:Male; D008938:Mitosis / Q000187:drug effects; D051381:Rats; D012627:Sebaceous Glands / Q000166:cytology / Q000502:physiology*; D012629:Sebum / Q000378:metabolism*; D012867:Skin; D014020:Tissue Extracts / Q000494:pharmacology*
D006131:Growth Inhibitors; D014020:Tissue Extracts; D003703:Demecolcine