Paradoxical responsiveness of growth hormone to corticotropin-releasing factor in acromegaly.
Corticotropin-releasing factor elicited an increase in serum GH in two of six patients with acromegaly. Both patients also responded paradoxically to LHRH administration and one of them also to TRH, further illustrating the dedifferentiation of the receptors of the somatotrophs in acromegaly.
D000172:Acromegaly / Q000378:metabolism*; D000328:Adult; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D007987:Gonadotropin-Releasing Hormone; D013973:Thyrotropin-Releasing Hormone; D013006:Growth Hormone; D003346:Corticotropin-Releasing Hormone