[The effects of prostaglandin synthetase inhibitor on male infertility].
From August 1979 to August 1981, 272 patients with the chief complaints of sterility visited our University Hospital. Flurbiprofen was administered to 40 of the 164 cases of idiopathic male sterility. Flurbiprofen of 120 mg was administered daily for 3 consecutive months. Drug use was discontinued in 2 cases because of severe digestive symptoms. Semen findings were compared before and after the medication. In the cases with sperm concentration over 10 X 10(6)/ml, sperm concentration and motility were improved in 26.9% and 23.1%, respectively. In the cases with sperm concentration under 10 X 10(6)/ml, sperm concentration and motility were effective in 8.3% and 25.0%, respectively. LH and FSH levels in blood were not different between before and after the administration. On the other hand, testosterone level in blood tended to increase a little, but not with statistically significance. Digestive symptoms and skin eruption were found in 4 cases and one, respectively.
D000328:Adult; D016861:Cyclooxygenase Inhibitors; D004341:Drug Evaluation; D005480:Flurbiprofen / Q000009:adverse effects / Q000627:therapeutic use*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy* / Q000503:physiopathology; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011422:Propionates / Q000627:therapeutic use*; D013076:Sperm Count; D013081:Sperm Motility; D013739:Testosterone / Q000097:blood
D016861:Cyclooxygenase Inhibitors; D011422:Propionates; D013739:Testosterone; D005480:Flurbiprofen; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone