title: Effect of mitomycin C on bone marrow cells in mice.
abstract: The total and differential cell counts of femoral bone marrow and peripheral reticulocyte counts were determined in male ddY mice up to day 11 after an intraperitoneal injection of 2 mg/kg of mitomycin C. Total marrow cell counts showed a minimum value on day 2 after the injection, and then recovered to the control level on day 7. In the differential cell counts, the minimum values were observed on day 1 for proerythroblasts and basophilic erythroblasts, on day 2 for polychromatic erythroblasts, and on day 4 for mature neutrophils. Recovery was seen from the 4th to 7th days after injection. Marrow lymphocytes showed a maximum value when the total counts were minimum. The peripheral reticulocytes almost disappeared 4 days after the injection, and recovered to the pretreatment level on day 11.
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002452:Cell Count; D004900:Erythroblasts; D006098:Granulocytes; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D016685:Mitomycin; D008937:Mitomycins / Q000633:toxicity*; D012156:Reticulocytes
chemical_list: D008937:Mitomycins; D016685:Mitomycin