Release of arachidonic acid: a new function of the late complement components.
Incubation of Ehrlich-ascites cells with sublytic complement doses results in degradation of membrane phospholipids and release of arachidonic acid. Phospholipase A2 blockers inhibit arachidonic acid release indicating a phospholipase dependent cleavage of the phospholipids. Phospholipase A2 is apparently activated during complement-membrane interaction, representing a new reactivity of the late complement components.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D002286:Carcinoma, Ehrlich Tumor / Q000503:physiopathology; D002462:Cell Membrane / Q000502:physiology; D003165:Complement System Proteins / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D009000:Monocytes / Q000502:physiology; D010741:Phospholipases A / Q000037:antagonists & inhibitors / Q000378:metabolism; D054467:Phospholipases A2; D010743:Phospholipids / Q000378:metabolism
D001095:Arachidonic Acids; D010743:Phospholipids; D016718:Arachidonic Acid; D003165:Complement System Proteins; D010741:Phospholipases A; D054467:Phospholipases A2