title: [Genetic, biochemical and functional study of the H-Y antigen in man].
abstract: H-Y antigen, first described as a male minor transplantation antigen, is unvarying associated with testicular differentiation, more than the presence of Y chromosome. The weak reactivity of anti H-Y serum needs quantitative and very sensitive tests to detect presence or absence of H-Y. This antigen may act as an hormone, to induce testicular differentiation of target cells, bearing a specific receptor at their surface. The relationship between an H-Y molecule immunologically defined by its antigenicity and H-Y factor defined by its function to induce testicular organogenesis must be determined.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002462:Cell Membrane / Q000276:immunology; D005260:Female; D006182:H-Y Antigen / Q000235:genetics* / Q000276:immunology / Q000302:isolation & purification; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D008722:Methods; D009154:Mutation; D011485:Protein Binding; D013737:Testis / Q000166:cytology; D014178:Translocation, Genetic; D001613:beta 2-Microglobulin / Q000378:metabolism
chemical_list: D006182:H-Y Antigen; D008565:Membrane Proteins; D001613:beta 2-Microglobulin
vernacular_title: Etude génétique, biochimique et fonctionnelle de l'antigène H-Y chez l'homme.