Reversal by verapamil of defect in sodium transport in leucocytes in essential hypertension.
The effect of treatment with verapamil on cell sodium transport was studied in the leucocytes of patients with essential hypertension. Previously described abnormalities of sodium efflux rate constant and intracellular sodium content were confirmed, the component of the sodium efflux rate constant sensitive to ouabain being lower and the intracellular sodium content higher in the patients compared with controls. Verapamil reversed these abnormalities and reduced blood pressure.
D000328:Adult; D000368:Aged; D001693:Biological Transport, Active / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012964:Sodium / Q000097:blood*; D014700:Verapamil / Q000627:therapeutic use*
D012964:Sodium; D014700:Verapamil