Cytogenetic and functional studies of leukocytes with Pelger-Huët anomaly.
A cytogenetic study was undertaken in 15 cases of Pelger-Huët (P-H) anomaly in 3 families. An enlarged short arm of chromosome 22 (22p+) was found in 14 cases, but in these families 4 cases without P-H anomaly did not show 22p+ in the karyotype. In P-H anomaly, delayed skin hypersensitivity reactions, levels of serum IgG, IgM and IgA, lymphocyte subpopulations, and natural killer and antibody-dependent, cell-mediated cytotoxicity activities were within normal range. The level of serum IgE, mitogen responses in peripheral blood lymphocyte and plaque-forming cell counts were also within normal range with the exception of a case with atopic eczema. Enzymatic activities, nitroblue tetrazolium reduction and phagocytic capacities of neutrophils appeared normal. Abnormalities of neutrophils in cases of P-H anomaly, as compared with normal subjects, were also negative in examinations for chemotaxis and spontaneous migration under agarose and in a membrane filter.
D000293:Adolescent; D000920:Antibody-Dependent Cell Cytotoxicity; D002634:Chemotaxis, Leukocyte; D002648:Child; D002869:Chromosome Aberrations; D002904:Chromosomes, Human, 21-22 and Y; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed; D007136:Immunoglobulins / Q000378:metabolism; D007223:Infant; D007694:Killer Cells, Natural / Q000276:immunology; D007962:Leukocytes / Q000502:physiology*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D009504:Neutrophils / Q000502:physiology; D010375:Pedigree; D010381:Pelger-Huet Anomaly / Q000097:blood / Q000235:genetics* / Q000276:immunology; D010835:Phytohemagglutinins / Q000494:pharmacology
D007136:Immunoglobulins; D010835:Phytohemagglutinins