Systemic treatment of septicaemia caused by P. aeruginosa with special reference to azlocillin.
Of the pathogens causing septicaemia due to Gram-negative bacteria at Zentrum der Inneren Medizin, Frankfurt, over a 7-year period (1974-80), 16.8 per cent were due to P. aeruginosa. Analysis of all septicaemias over this period, however, shows a decrease from 13 per cent in the 3-year period 1974-76 to 8 per cent in 1977-79 and 5 per cent P. aeruginosa septicaemia in 1980. The overall mortality rate was 66 per cent, most of the patients dying within 24 hours. Azlocillin and Piperacillin are at present the drugs of choice for systemic therapy of pseudomonas infections, preferably in combination with an aminoglycoside.
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001390:Azlocillin / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008826:Microbial Sensitivity Tests; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D018805:Sepsis / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D001390:Azlocillin