title: Quantitative polyphosphate-induced "prebiotic" peptide formation in H2O by addition of certain azoles and ions.
abstract: Aqueous solutions of 0.1 M amino acid and 0.1 M trimetaphosphate maintained at chosen pH values between 8.0 and 10.5 and at room temperature in the presence of imidazole or 1,2,4-triazole give rise after a few days to the corresponding peptides. Yields are highest when the pH is adjusted with concentrated NaOH or KOH instead of ammonia; in some cases glycine is quantitatively transformed within 10-15 days into peptides, mainly di-and tripeptides.
mesh_terms: D001393:Azoles; D002384:Catalysis; D006863:Hydrogen-Ion Concentration; D007477:Ions; D010455:Peptides; D011122:Polyphosphates; D014867:Water
chemical_list: D001393:Azoles; D007477:Ions; D010455:Peptides; D011122:Polyphosphates; D014867:Water