The metabolism of an exogenous lipid source during septic shock in the puppy.
Septic shock induces physiologic and hemodynamic responses that may alter the host's ability to metabolize an exogenous source of lipids. The present study examined the metabolic changes occurring during septic shock in the young animal receiving an intravenous fat emulsion. Five 8-wk-old male Beagle puppies were studied. Each animal served as his own control twice, during which time 14C-palmitic acid alone or with a 10% fat emulsion (Liposyn) was administered. Septic shock (cardiac output less than 50% of control) was induced with an intravenous bolus of live Escherichia coli. During shock the puppies received intravenous 14C-palmitic acid and Liposyn. The mean respiratory quotient for the shock dogs (0.96 +/- 0.01) was significantly (p less than 0.05) higher than that of the controls (0.83 +/- 0.06). The amount of expired 14CO2 was 25.0 +/- 15.9% for the shock animals, 53.9 +/- 28.1% for the Liposyn controls, and 75.7 +/- 30.5% for the controls receiving only 14C-palmitic acid (these differences are all significant, p less than 0.05). After the onset of shock, serum triglyceride levels peaked within 2 min at 851 +/- 540 mg/100 ml and remained elevated at 333 +/- 213 mg/100 ml. Triglyceride levels in the Liposyn control animals returned to baseline values (54 +/- 13 mg/100 ml) at the end of the 4-hr experimental period. Free fatty acids in the shock dogs reached a maximal level of 1.44 +/- 0.09 mEq/liter at 1 hr and remained at this elevated value for a significantly longer period of time than in the Liposyn control puppies. Glycerol value followed a similar pattern and cholesterol remain unchanged.(ABSTRACT TRUNCATED AT 250 WORDS)
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004285:Dogs; D004927:Escherichia coli Infections / Q000378:metabolism* / Q000628:therapy; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005990:Glycerol / Q000097:blood; D007328:Insulin / Q000097:blood; D050356:Lipid Metabolism; D010288:Parenteral Nutrition; D012772:Shock, Septic / Q000378:metabolism* / Q000628:therapy; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D005217:Fat Emulsions, Intravenous; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D014280:Triglycerides; D005990:Glycerol