Skeletal muscle cell abnormalities in acute hypophosphatemia during total parenteral nutrition.
Muscle tissue H2O, Na, K, Mg, Cl and total P were studied in 23 patients with acute hypophosphatemia during P-deficient total parenteral nutrition. Increased muscle extracellular water and low intracellular K and Mg with high intracellular Na were found. These abnormalities were detected either in previously underfed patients with low muscle P or in well-nourished, acutely ill subjects with muscle P near to normal. These findings show that acute depletion of extracellular inorganic P is associated with changes of muscle cell composition independently of muscle cell P content.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D001834:Body Water / Q000032:analysis; D004573:Electrolytes / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000032:analysis*; D009748:Nutrition Disorders / Q000097:blood; D010288:Parenteral Nutrition / Q000009:adverse effects*; D010289:Parenteral Nutrition, Total / Q000009:adverse effects*; D010710:Phosphates / Q000097:blood*
D004573:Electrolytes; D010710:Phosphates