title: [Effect of methylmethane sulfonate-sensitive mutations on nondisjunction and loss of sex chromosomes in Drosophila males].
abstract: The MMS-sensitive mutants mus(1) 120M1 and mus(1) 121M1 of Drosophila melanogaster were investigated regarding their effects on spontaneous and X-ray induced (2000 R) aneuploidy in male germ cells, during different stages of spermatogenesis. In matings of males carrying mus mutation and a doubly marked Y-chromosome (BsYy+) with repair proficient y f females, the frequencies of partial loss, nondisjunctions and especially complete loss were significantly higher than in the control. Apparently, MMS-sensitive mutants deal with meiotic processes and maintenance of chromosome structural stability both in females and in males, in somatic and germ cells.
mesh_terms: D000782:Aneuploidy; D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics* / Q000528:radiation effects; D004351:Drug Resistance; D005260:Female; D008297:Male; D008741:Methyl Methanesulfonate / Q000633:toxicity*; D009154:Mutation; D009630:Nondisjunction, Genetic; D012730:Sex Chromosomes; D013091:Spermatogenesis
chemical_list: D008741:Methyl Methanesulfonate
vernacular_title: Vliianie chuvstvitel'nykh k metilmetansul'fonatu mutatsiĭ na neraskhozhdenie i poteri polovykh khromosom u samtsov drozofily.