Antibody activity in perilymph from rats with type II collagen-induced autoimmune inner ear disease.
Rats were immunized with native type II bovine collagen to induce autoimmune inner ear disease, and the antibody activity in the inner ear fluid was measured. Antibody activity against type II collagen was detected in the perilymph at about 10% to 20% of serum level. Thus, the presence of antibody against type II collagen in inner ear fluid may imply an immune injury mechanism in inner ear diseases.
D000818:Animals; D000906:Antibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology*; D002417:Cattle; D003094:Collagen / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D007114:Immunization; D007759:Labyrinth Diseases / Q000209:etiology / Q000276:immunology*; D007761:Labyrinthine Fluids / Q000276:immunology*; D010498:Perilymph / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains
D000906:Antibodies; D003094:Collagen