Detection of compounds immunologically related to arachidonic acid transformation products in extracts of invertebrates.
Organic extracts of Terpios zeteki, a sponge from the phylum Porifera, Aplysia californica and Helix aspersa, two species from the phylum Mollusca, and Arbacia, the sea urchin, from the phylum Echinodermata, contained compounds that appeared by radioimmunoassays to be HETE, PGE2, PGF2 alpha, and 6-keto-PGF1 alpha, the non-enzymatic hydrolytic product of PGI2. However, lack of coincidence of their retention times on HPLC with authentic oxygenation products of arachidonic acid suggested that most of the immunologically active compounds were derivatives of arachidonic acid metabolites or products derived from polyunsaturated fatty acids other than arachidonic acid.
D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D000818:Animals; D001048:Aplysia / Q000378:metabolism; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D001711:Biotransformation; D006372:Helix, Snails / Q000378:metabolism; D007448:Invertebrates / Q000378:metabolism*; D011161:Porifera / Q000378:metabolism; D011453:Prostaglandins / Q000378:metabolism; D011863:Radioimmunoassay; D012617:Sea Urchins / Q000378:metabolism
D001095:Arachidonic Acids; D011453:Prostaglandins; D016718:Arachidonic Acid; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid