Induction of transplantation resistance to murine L1210 leukemia cells in BCG-primed mice by immunization with tuberculin protein-coupled L1210 cells.
By priming with Bacillus Calmette-Guérin (BCG) and subsequent immunization with L1210 leukemia cells to which purified protein derivative of tuberculin (PPD) had been coupled, a resistance to L1210 leukemia but not to syngeneic P388 leukemia was induced in DBA/2 and CDF1 mice. Separate injections of mitomycin C-treated L1210 cells and PPD also induced the resistance, but it was established only when they were administered simultaneously. PPD-coupled cells seemed to play a more important role than BCG, since the immunoprophylaxis was observed when L1210 challenge was made at the sites of PPD-L1210 immunization, but was not observed when L1210 challenge was made at the sites of BCG priming.
D000818:Animals; D007114:Immunization; D007167:Immunotherapy; D007939:Leukemia L1210 / Q000276:immunology / Q000517:prevention & control*; D007941:Leukemia P388 / Q000276:immunology; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D009163:Mycobacterium bovis / Q000276:immunology*; D009368:Neoplasm Transplantation; D013997:Time Factors; D014373:Tuberculin / Q000276:immunology*
D008937:Mitomycins; D014373:Tuberculin; D016685:Mitomycin