title: Fucoidan blocks macrophage activation in an inductive phase but promotes macrophage activation in an effector phase.
abstract: It has been suggested that some polysaccharides play important roles in immune responses. Therefore, we used various types of polysaccharides for analysis of macrophage-mediated tumor cell killing. We report here that fucoidan blocked macrophage activation occurs in an inductive phase but enhanced macrophage activation appears in an effector phase.
mesh_terms: D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D066298:In Vitro Techniques; D008262:Macrophage Activation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental / Q000276:immunology; D011134:Polysaccharides / Q000494:pharmacology*; D012566:Sizofiran / Q000494:pharmacology
chemical_list: D011134:Polysaccharides; D012566:Sizofiran; C007789:fucoidan