title: Treatment of acne vulgaris comparing two similar lotion formulations, one with ('Actinac') and one without chloramphenicol.
abstract: A double-blind, randomized study was carried out in 37 patients with acne vulgaris to compare the efficacy of two similar lotion formulations, one with ('Actinac') and the other without chloramphenicol (4%). Patients used one or other of the two formulations twice daily for the first 4 days and then at night only for the remainder of the 3-month trial period. At the end of the first month's treatment, the group treated with the full formulation showed a statistically significant greater reduction in lesion count score than in the group receiving the formulation without chloramphenicol. Both treatments produced statistically significant reductions in lesion counts at all monthly follow-up visits. After 3-months' treatment, the mean lesion count score was reduced from 28.8 to 9.3 in the full formulation-treated group and from 39.5 to 14.3 in the formulation minus chloramphenicol group, but this difference did not reach statistical significance.
mesh_terms: D000152:Acne Vulgaris / Q000188:drug therapy*; D000287:Administration, Topical; D000481:Allantoin / Q000008:administration & dosage / Q000627:therapeutic use*; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D011232:Chemical Precipitation; D002701:Chloramphenicol / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations; D005079:Excipients / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D009539:Nicotinic Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D013455:Sulfur / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D005079:Excipients; D009539:Nicotinic Acids; D000481:Allantoin; C021650:hydrocortisone acetate; D002701:Chloramphenicol; D013455:Sulfur; D006854:Hydrocortisone