title: Heat-induced changes in respiratory pathways and mitochondrial structure during microcycle conidiation of Neurospora crassa.
abstract: Changes in both respiratory pathways and mitochondrial structure of Neurospora crassa occurred under conditions of microcycle conidiation. Upon heat-treatment at 46 degrees C, conidia developed a highly cyanide-insensitive, hydroxamate-sensitive respiration associated with morphological alterations in mitochondrial membranes; such changes were time-dependent. When heat-treated conidia were shifted down to 25 degrees C, the alternate, hydroxamate-sensitive respiration decreased significantly, paralleling the recovery of well-cristated mitochondria with an electron-dense matrix in the germ tubes. The decrease in hydroxamate-sensitivity was associated with two periods of increase in cyanide sensitivity corresponding to the events of germination and precocious proconidial budding.
mesh_terms: D006358:Hot Temperature; D006877:Hydroxamic Acids / Q000494:pharmacology; D008928:Mitochondria / Q000648:ultrastructure*; D009491:Neurospora / Q000378:metabolism*; D009492:Neurospora crassa / Q000254:growth & development / Q000378:metabolism* / Q000648:ultrastructure; D010101:Oxygen Consumption / Q000187:drug effects; D011190:Potassium Cyanide / Q000494:pharmacology; D012457:Salicylamides / Q000494:pharmacology; D013172:Spores, Fungal
chemical_list: D006877:Hydroxamic Acids; D012457:Salicylamides; C005703:salicylhydroxamic acid; D011190:Potassium Cyanide