title: Enzymes of purine metabolism and membrane phenotype in malignant cells of some leukemia patients.
abstract: Lymphocytes from patients with chronic lymphatic leukemia, acute lymphoblastic leukemia and acute myeloid leukemia have been characterized by the activity of two enzymes involved in purine metabolism--adenosine deaminase and purine nucleoside phosphorylase and by the analysis of surface marker expression. The data obtained suggest that the activity of enzymes of purine metabolism can be used as a complementary diagnostic marker to conventional cell surface characteristics for the classification of lymphoproliferative diseases, especially in the case of T-acute lymphoblastic leukemia. The changes of the purine pathway enzymes may prove to be useful also as therapeutic determinants in hemopoietic neoplasia, particularly in the lymphoid malignancies.
mesh_terms: D000243:Adenosine Deaminase / Q000032:analysis*; D000911:Antibodies, Monoclonal; D002462:Cell Membrane / Q000276:immunology; D003593:Cytoplasm / Q000276:immunology; D003937:Diagnosis, Differential; D006801:Humans; D007938:Leukemia / Q000201:enzymology* / Q000276:immunology; D007945:Leukemia, Lymphoid / Q000201:enzymology / Q000276:immunology; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology / Q000276:immunology; D008214:Lymphocytes / Q000145:classification / Q000201:enzymology* / Q000276:immunology; D009700:Nucleoside Deaminases / Q000032:analysis*; D010430:Pentosyltransferases / Q000032:analysis*; D011683:Purine-Nucleoside Phosphorylase / Q000032:analysis*; D012397:Rosette Formation
chemical_list: D000911:Antibodies, Monoclonal; D010430:Pentosyltransferases; D011683:Purine-Nucleoside Phosphorylase; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase