Distribution of sodium valproate and GABA metabolism in CNS of the rat.
The distribution of VPA has been investigated in several brain areas of the rat, and GABA increases were measured. A biphasic exponential decay was observed for VPA; the slowest decrease was noted in the olfactory bulbs and in the hypothalamus where GAD and GABA-T activities were the highest. The data may be correlated with the prolonged effect of VPA in these areas.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014635:Valproic Acid / Q000097:blood / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000097:blood / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D014635:Valproic Acid