Effect of glucagon on human gastric mucosa: histochemical studies.
We studied the effects of glucagon (2 mg intravenously) on the histochemical localization and staining intensity of 10 enzymes in human gastric mucosa. Glucagon caused a significant increase in the histochemical activity of glucose-6-phosphate dehydrogenase in the undifferentiated neck cells and mucous cells of the foveolae and of ATPase activity in and around the mucosal capillary walls. Glucagon also stimulated mucus secretion from the surface epithelial cells. These changes were observed 15 and 30 min after glucagon in the oxyntic, but no pyloric mucosa. they indicate that glucagon, in addition to its effect on parietal cells, also affects other structures in human gastric mucosa.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000328:Adult; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D005934:Glucagon / Q000494:pharmacology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans
D005934:Glucagon; D005954:Glucosephosphate Dehydrogenase; D000251:Adenosine Triphosphatases