[Influence of the inoculum effect on the MIC and MBC of 5 beta-lactams against Pseudomonas aeruginosa].
MICs and MBCs of five beta-lactams , i.e. ticarcillin, azlocillin, piperacillin, cefsulodin and ceftazidime for 20 strains of Pseudomonas aeruginosa were studied with inocula ranging from 10(3) to 10(9) CFU/ml. Each antibiotic exhibited an inoculum effect at 10(5)-10(7) CFU/ml. However, ticarcillin had smaller MIC and MBC increments than the four other drugs, making it more suitable in certain cases.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001390:Azlocillin; D002441:Cefsulodin; D002442:Ceftazidime; D002511:Cephalosporins / Q000494:pharmacology; D006801:Humans; D008826:Microbial Sensitivity Tests / Q000379:methods; D010406:Penicillins / Q000494:pharmacology; D010878:Piperacillin / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013982:Ticarcillin / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D010406:Penicillins; D002442:Ceftazidime; D013982:Ticarcillin; D001390:Azlocillin; D002441:Cefsulodin; D010878:Piperacillin
Influence de l'effet inoculum sur les CMI et les CMB de cinq bêtalactamines vis-à-vis de Pseudomonas aeruginosa.