title: [Differentiation of the effects of diazepam on self-stimulation behavior as a function of the structure of the stimulated brain].
abstract: The effect of diazepam was tested on self-stimulation in 21 mice with a bipolar electrode in lateral hypothalamus (HL), dorsolateral hippocampus (HPC) or lateral entorninal cortex (CEL). Diazepam at 0.5, 1 and 2 mg/kg significantly increased self-stimulation rates in HL while 4 and 8 mg/kg had no significant effect. Similar increases were seen in CEL mice but high doses produced a significant suppression. HPC animals showed a drastic suppression of self-stimulation beginning at 2 mg/kg of diazepam, lower doses having no significant effect. The results demonstrate that entorhinal and hippocampal self-stimulation involve at least partly independent neuronal mechanisms and point to a possible inhibitory influence of HPC and CEL.
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000502:physiology*; D003975:Diazepam / Q000494:pharmacology*; D006624:Hippocampus / Q000502:physiology; D007026:Hypothalamic Area, Lateral / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012653:Self Stimulation / Q000187:drug effects*
chemical_list: D003975:Diazepam
vernacular_title: Différentiation des effets du diazépam sur le comportement d'autostimulation en fonction de la structure cérébrale stimulée.