title: Plasmid patterns and in-vitro susceptibility of penicillinase-producing Neisseria gonorrhoeae with emphasis on thiamphenicol: results of surveillance in The Netherlands.
abstract: Susceptibility to thiamphenicol was tested, and plasmids were characterized for 1925 strains of penicillinase-producing Neisseria gonorrhoeae (PPNG) isolated in The Netherlands in 1981 and 1982. Of the 1925 isolates, 771 harbored the so-called "Asia" (4.5-megadalton) resistance plasmid and 1154 had the so called "Africa" (3.2-megadalton) plasmid. Isolates in the first group were usually inhibited by 0.25 microgram of thiamphenicol ml, while the MIC for the latter isolates was 1-2 micrograms/ml. A similar bimodal distribution of MICs has been observed for non-PPNG isolates. In the period covering this study, a substantial shift from predominance of the "Africa" type to that of the "Asia" type of N. gonorrhoeae was observed.
mesh_terms: D000349:Africa; D001208:Asia; D006801:Humans; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D009426:Netherlands; D010405:Penicillinase / Q000096:biosynthesis*; D011815:R Factors; D013839:Thiamphenicol / Q000494:pharmacology*
chemical_list: D010405:Penicillinase; D013839:Thiamphenicol