[Demonstration, during the regeneration of urodeles, of a dedifferentiating influence of cicatricial epithelium (study in Salamandra salamandra larvae)].
Grafts of wound epithelium have been performed on non-amputated limbs and blastema cells have been cultured alone or in the presence of normal epidermis and wound epithelium extracts. These experiments have shown a dedifferentiating and cytotoxic effect of wound epithelium. This effect appears governed by enzymes acting on the extracellular matrix and cell surfaces.
D000818:Animals; D004848:Epithelium / Q000502:physiology; D007814:Larva; D012038:Regeneration; D014562:Caudata / Q000502:physiology*; D014945:Wound Healing
Mise en évidence, au cours de la régénération des Urodèles, d'une influence dédifférenciatrice de l'épithélium cicatriciel (étude chez la larve de Salamandra salamandra).