Role of T lymphocytes in the resistance and immunopathology of experimental Chagas' disease. I. Histopathological studies.
The results reported here show that Trypanosoma cruzi can parasitize almost all tissues of mice; however, the T-dependent immune response controls parasite invasion, leading undesirable immunopathological effects. Inflammatory infiltrate was rare in heart or skeletal muscle and other organs of Nu/Nu, but was abundant in tissues of Nu/+ mice. Cellular inflammatory lesions could be induced in Nude mice by the transfer of lymph node cells from Nu/+ animals infected with T. cruzi.
D000311:Adrenal Glands / Q000473:pathology; D000818:Animals; D014355:Chagas Disease / Q000276:immunology* / Q000473:pathology; D005260:Female; D007113:Immunity, Innate; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009132:Muscles / Q000473:pathology; D010179:Pancreas / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*; D014349:Trypanosoma cruzi