title: Chromosomal location of human T-cell receptor gene Ti beta.
abstract: A complementary DNA probe corresponding to the beta-chain gene of Ti, the human T lymphocyte receptor, has been molecularly cloned. The chromosomal origin of the Ti beta gene was determined with the complementary DNA by screening a series of 12 cell hybrid (mouse X human) DNA's containing overlapping subsets of human chromosomes. DNA hybridization (Southern) experiments showed that the human Ti beta gene resides on chromosome 7 and is thus not linked to the immunoglobulin loci or to the major histocompatibility locus in humans.
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D003001:Cloning, Molecular; D004247:DNA; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D006822:Hybrid Cells; D007145:Immunoglobulin kappa-Chains / Q000235:genetics; D008285:Major Histocompatibility Complex; D051379:Mice; D009693:Nucleic Acid Hybridization; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*
chemical_list: D007145:Immunoglobulin kappa-Chains; D011948:Receptors, Antigen, T-Cell; D004247:DNA