Synapsin I (protein I) in different brain regions in senile dementia of Alzheimer type and in multi-infarct dementia.
Synapsin I (Protein I), a neuron-specific phosphoprotein enriched in presynaptic nerve terminals, has been used as a quantitative marker for the density of nerve terminals in five brain regions (caudate nucleus, cingulate gyrus, hippocampus, mesencephalon and putamen) from patients who had suffered from Alzheimer disease/senile dementia of Alzheimer type (AD/SDAT), from patients with multi-infarct dementia (MID), and from age-matched controls. Samples were obtained at autopsy. Lower levels of Synapsin I were observed in the hippocampus of patients with AD/SDAT but not with MID. There were no significant differences in Synapsin I levels between patients and controls in any of the other four brain regions examined.
D001923:Brain Chemistry; D002421:Caudate Nucleus / Q000032:analysis; D003704:Dementia / Q000378:metabolism*; D006179:Gyrus Cinguli / Q000032:analysis; D006624:Hippocampus / Q000032:analysis; D006801:Humans; D008636:Mesencephalon / Q000032:analysis; D009419:Nerve Tissue Proteins / Q000032:analysis*; D011699:Putamen / Q000032:analysis; D011863:Radioimmunoassay; D016704:Synapsins
D009419:Nerve Tissue Proteins; D016704:Synapsins