title: Effect of lithium carbonate on the bone marrow of patients treated for haematological malignancies.
abstract: Patients suffering from haematological malignancies were treated with Li2CO3 in order to investigate its effect on the bone marrow depleted by cytotoxic therapy. The results revealed that lithium induced a great number of cells, especially myeloids, in the previously hypoplastic bone marrow. There was a close relationship between the cellularity of the bone marrow and the changes in peripheral WBC and granulocyte counts during lithium carbonate treatment.
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D005260:Female; D006098:Granulocytes / Q000166:cytology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D007962:Leukocytes / Q000166:cytology; D008094:Lithium / Q000494:pharmacology*; D016651:Lithium Carbonate; D008297:Male
chemical_list: D000970:Antineoplastic Agents; D016651:Lithium Carbonate; D008094:Lithium