Effect of polyvinyl phosphonates and ethane hydroxy diphosphonate on mineralization of ectopic bone.
The effects of polymeric polyphosphonate and of ethane hydroxydiphosphonate on the development of ectopic bone were compared at different stages of bone development. The diphosphonate affected bone development at different stages, as reflected by alkaline phosphatase and aryl sulphatase activities, as well as by the creation of calcium ions by bone and on its readiness to undergo isotopic exchange. The polymeric polyphosphonate (mol. wt., 3500-8000), on the other hand, did not exhibit any of these effects, although it did inhibit the activity of the enzymes in vitro to an extent comparable with that of the diphosphonate. The results corroborate the assumption that the effects of polymeric polyphosphonates on hard tissues are confined to the extracellular space while the effects of diphosphonates on bone development are due to intracellular activity and not to sequestering of extracellular calcium.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001192:Arylsulfatases / Q000378:metabolism; D001842:Bone and Bones / Q000187:drug effects*; D002118:Calcium / Q000097:blood; D012968:Etidronic Acid / Q000494:pharmacology*; D008297:Male; D008903:Minerals / Q000378:metabolism*; D063065:Organophosphonates / Q000494:pharmacology*; D009943:Organophosphorus Compounds; D010012:Osteogenesis / Q000187:drug effects; D010758:Phosphorus / Q000097:blood; D011145:Polyvinyls / Q000494:pharmacology*; D051381:Rats
D008903:Minerals; D063065:Organophosphonates; D009943:Organophosphorus Compounds; D011145:Polyvinyls; D010758:Phosphorus; C020477:polyphosphonate; D000469:Alkaline Phosphatase; D001192:Arylsulfatases; D012968:Etidronic Acid; D002118:Calcium