Morphological and biochemical criteria for evaluating cytotoxic effects of antiviral substances.
To evaluate the cytotoxicity of antiviral substances in a primary screening programme both biological (viability and alterations of cell morphology) and biochemical methods. (51Cr release) are recommended. Because of their different sensitivities the examination of primary as well as permanent cell lines is necessary.
D000818:Animals; D000998:Antiviral Agents / Q000633:toxicity*; D002417:Cattle; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical; D006801:Humans; D006812:Humic Substances / Q000633:toxicity; D008297:Male; D010636:Phenols / Q000633:toxicity; D011817:Rabbits; D013045:Species Specificity
D000998:Antiviral Agents; D006812:Humic Substances; D010636:Phenols