Effects of nifedipine on pulmonary arterial hypertension in patients with respiratory insufficiency without acute failure.
Permanent pulmonary arterial hypertension is a standard part of the prognosis for patients with chronic respiratory insufficiency. As a decrease of pulmonary arterial hypoxic vasoconstriction may be obtained by calcium antagonists, we studied the effects of nifedipine (10 mg sublingually) in 10 patients with chronic respiratory insufficiency without acute respiratory failure. Our results show that maximal expiratory air flow was not altered. The pulmonary antihypertensive action of this drug, which is less effective than oxygen breathing at low concentration, was associated with a constant decrease of arterial oxygen partial pressure; the oxygen transport was not sustained for every patient. This result suggests that considerable caution should be exercised in using this drug for the treatment of pulmonary arterial hypertension in patients with chronic respiratory insufficiency without acute failure.
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002908:Chronic Disease; D005540:Forced Expiratory Flow Rates; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000503:physiopathology; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology; D000860:Hypoxia / Q000150:complications; D008168:Lung / Q000098:blood supply; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D010100:Oxygen / Q000097:blood; D012131:Respiratory Insufficiency / Q000150:complications*; D014655:Vascular Resistance / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects
D002245:Carbon Dioxide; D009543:Nifedipine; D010100:Oxygen