Effect of D,L-alpha-difluoromethylornithine on murine mammary carcinogenesis.
The development of chemically-induced mammary gland carcinomas in rats was dramatically suppressed by provision of a 1% solution of D,L-alpha-difluoromethylornithine (DFMO) in drinking water. Treatment with DFMO significantly reduced cancer incidence and the average size and number of cancers per rat and prolonged the cancer-free time. DFMO appears to be effective in blocking some aspect of the promotion stage of chemically induced mammary carcinogenesis in the rat.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000518:Eflornithine; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000032:analysis / Q000517:prevention & control*; D009952:Ornithine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D065108:Ornithine Decarboxylase Inhibitors; D011073:Polyamines / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
D000970:Antineoplastic Agents; D065108:Ornithine Decarboxylase Inhibitors; D011073:Polyamines; D009952:Ornithine; D000518:Eflornithine