SCE frequencies in lymphocytes of systemic lupus erythematosus patients.
The frequency of sister-chromatid exchanges (SCEs) was investigated in peripheral lymphocytes of lupus erythematosus patients and compared with values obtained for healthy controls. Irrespective of the kind of medical treatment, an increased level of spontaneously occurring SCEs could be demonstrated in lupus patients. In addition to spontaneously occurring SCEs, mitomycin C (MMC)-induced SCEs were evaluated. No difference between patients and controls was found with respect to MMC-induced SCEs.
D000328:Adult; D000368:Aged; D000903:Antibiotics, Antineoplastic / Q000633:toxicity; D001973:Bromodeoxyuridine; D002478:Cells, Cultured; D003434:Crossing Over, Genetic; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008214:Lymphocytes / Q000166:cytology*; D008875:Middle Aged; D016685:Mitomycin; D008937:Mitomycins / Q000633:toxicity; D012016:Reference Values; D012854:Sister Chromatid Exchange
D000903:Antibiotics, Antineoplastic; D008937:Mitomycins; D016685:Mitomycin; D001973:Bromodeoxyuridine