Action of suriclone in naturally and allyglycine-induced photosensitive baboons, Papio papio.
Suriclone (SC) is a new anxiolytic compound with a chemical structure different from that of benzodiazepines (BZD) but SC possesses a high affinity for the so-called BZD receptors. SC was tested in the naturally or the allylglycine-treated photosensitive baboon Papio papio. As active BZD administered by the intramuscular or oral route, this new compound possesses a marked protective effect against the excessive photosensitivity of the baboons, it blocks myoclonus following EEG spike and waves discharges induced by intermittent light stimulation; as BZD again, SC can induce spontaneous myoclonus not accompanied by EEG spike and wave discharges.
D000284:Administration, Oral; D000501:Allylglycine; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001570:Benzodiazepinones / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D005442:Flumazenil; D007273:Injections, Intramuscular; D009287:Naphthyridines; D010215:Papio / Q000235:genetics; D010787:Photosensitivity Disorders / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D010879:Piperazines / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D013457:Sulfur Compounds
D001570:Benzodiazepinones; D009287:Naphthyridines; D010879:Piperazines; D013457:Sulfur Compounds; D000501:Allylglycine; D005442:Flumazenil; C037283:suriclone