Riboflavin analogs utilized for metabolism by a Lactobacillus casei mutant.
Several new halogen-containing riboflavin analogs that are antagonists for the stock strain of Lactobacillus casei have been found to be utilized by a mutant strain of the microorganism for growth and acid production. Riboflavin analogs consisting of all combinations of a single aliphatic group (methyl or ethyl) and a single halogen group (chloro or bromo) in positions 7 and 8 of the isoalloxazine nucleus possess this property. The analog devoid of substituents in positions 7 and 8 and the analog possessing a methyl group in position 7 and a cysteinyl group in position 8, were inert for both strains of the microorganism.
D000143:Acids / Q000096:biosynthesis; D007780:Lacticaseibacillus casei / Q000235:genetics / Q000378:metabolism*; D009154:Mutation; D012256:Riboflavin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D013329:Structure-Activity Relationship
D000143:Acids; D012256:Riboflavin