Neoplastic human T-cells capable of responding to multiple human alloantigens.
Monoclonally-derived neoplastic T-cells from a patient with cutaneous T-cell lymphoma respond to multiple human HLA-D antigens in mixed lymphocyte culture. The implications of this phenomenon relevant to normal T-cell function and to malignancy are discussed.
D002471:Cell Transformation, Neoplastic; D002999:Clone Cells / Q000276:immunology; D006680:HLA Antigens; D006801:Humans; D007519:Isoantigens; D007621:Karyotyping; D007959:Lymphocyte Culture Test, Mixed; D008223:Lymphoma / Q000276:immunology; D011948:Receptors, Antigen, T-Cell; D012878:Skin Neoplasms / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D006680:HLA Antigens; D007519:Isoantigens; D011948:Receptors, Antigen, T-Cell