Ellipsoids in the human spleen.
A study of ellipsoids (EL) in the human spleen was done on 25 surgically resected specimens in order to assess the number of EL, their structure, the nature of the cuff cells and the problem of lymphocyte traffic through their wall. The results show that an average spleen of 200 g contains 1.6 X 10(7) EL. They are localized in a constant segment of the vascular tree, just at the transition of the penicilliary arterioles into capillaries and they consist of a capillary (not an arteriole) surrounded by a cuff of cells. These cells are neither endothelial nor smooth muscle cells, display lysosomal activity and are considered as fixed specialized pericapillary cells capable of cytoplasmic expansion. Since their number is inconstant in different individuals and in different species they are considered to be dynamic histological structures. Because of the constant presence of lymphocytes in their walls we consider the EL to be a transit system for lymphocytes and the splenic equivalent of the high endothelial venules in the lymph nodes.
D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000166:cytology; D002196:Capillaries / Q000166:cytology* / Q000648:ultrastructure; D002465:Cell Movement; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D013154:Spleen / Q000098:blood supply* / Q000166:cytology / Q000648:ultrastructure; D013601:T-Lymphocytes / Q000166:cytology