A discussion of the dynamic illegible "E" test: a new method of screening for aminoglycoside vestibulotoxicity.
Although aminoglycoside antibiotics have been successful in controlling infections, the side effects of these drugs include vestibulotoxicity that can be irreversible. In a patient with intact visual and proprioceptive systems, the effects can be compensated for, but in a patient with impairment of one of these systems, loss of vestibular function can be devastating. There is little if any agreement in the literature about how to monitor patients undergoing therapy with these drugs. A reading test is described. It uses the ability of the vestibulo-ocular reflex to stabilize an image during head movement. The test is quantified using change in visual acuity with head movement to monitor damage to the vestibular system. Patients with loss of vestibular function are incapable of performing the test. Some evidence points to the test being more sensitive than standard caloric irrigations. We propose that it be used to monitor patients receiving aminoglycoside antibiotics.
D000328:Adult; D000368:Aged; D000617:Aminoglycosides / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D005260:Female; D005839:Gentamicins / Q000009:adverse effects*; D006257:Head; D006801:Humans; D007759:Labyrinth Diseases / Q000139:chemically induced / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009068:Movement; D011932:Reading; D014724:Vestibular Function Tests / Q000379:methods*; D014722:Vestibule, Labyrinth / Q000187:drug effects*; D014792:Visual Acuity
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins