Alfentanil-supplemented anaesthesia for short procedures. A double-blind comparison with fentanyl.
Eighty unpremedicated female patients undergoing short gynaecological procedures were randomly allocated to four groups and received either alfentanil or fentanyl (double-blind), together with Althesin-oxygen or methohexitone-nitrous oxide'-oxygen. Recovery from anaesthesia was assessed using the post-box test and the deletion of p. There was a significantly greater frequency of vomiting after operation (P less than 0.05) with methohexitone compared with Althesin and with fentanyl compared with alfentanil, and a significantly greater frequency of pain on injection (P less than 0.001) with methohexitone compared with Althesin. The alfentanil groups completed the post-box test significantly earlier after operation than the fentanyl groups (P less than 0.05). We conclude that alfentanil may offer a significant advantage over fentanyl as an analgesic supplement to i.v. anaesthesia for short procedures.
D000759:Adjuvants, Anesthesia; D015760:Alfentanil; D000768:Anesthesia, General; D004107:Dilatation and Curettage; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl / Q000031:analogs & derivatives* / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D011897:Random Allocation; D012119:Respiration / Q000187:drug effects; D013997:Time Factors
D000759:Adjuvants, Anesthesia; D015760:Alfentanil; D005283:Fentanyl