Effect of protein concentration and blood clots on the "in vitro" anti-Pseudomonas aeruginosa activity of cefoperazone.
The effect of the protein content in the medium and blood clots on the anti-Pseudomonas aeruginosa activity of cefoperazone was studied and its activity against strains of the bacteria in the blood clots investigated. Medium protein content, blood clots and the localization of the microorganism all appeared to effect the antibacterial activity of cefoperazone: the therapeutic implications of these findings are briefly discussed.
D001777:Blood Coagulation; D001798:Blood Proteins / Q000378:metabolism*; D002438:Cefoperazone / Q000494:pharmacology*; D003470:Culture Media; D006801:Humans; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
D001798:Blood Proteins; D003470:Culture Media; D002438:Cefoperazone