Mitomycin C induced chromosome damage in fetal blood cultures and prenatal diagnosis of Fanconi's anaemia.
We report the use of fetal blood for the prenatal diagnosis of Fanconi anaemia (FA). The clastogenic action of Mitomycin C (MMC) is compared in blood cultures from different fetuses, normal controls and FA heterozygotes. The fetus at risk is shown to suffer from FA on the grounds of excessive chromosome breakage, both spontaneous and MMC induced.
D000328:Adult; D000741:Anemia, Aplastic / Q000175:diagnosis*; D002869:Chromosome Aberrations; D002873:Chromosome Fragility / Q000187:drug effects; D005199:Fanconi Anemia / Q000175:diagnosis* / Q000235:genetics; D005260:Female; D005312:Fetal Blood / Q000166:cytology; D006801:Humans; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D011247:Pregnancy; D011296:Prenatal Diagnosis
D008937:Mitomycins; D016685:Mitomycin