Intravenous ketoprofen in renal colic: a placebo-controlled pilot study.
In a double-blind trial 30 patients with renal colic were allocated at random to receive 200 mg of ketoprofen, 1 gm of lysine acetylsalicylate, or placebo by intravenous bolus injection. The patients were asked to rate their pain at intervals within three hours of injection and to indicate on a visual analogue scale the overall pain relief obtained. Both ketoprofen and lysine acetylsalicylate proved significantly more effective than placebo, with no apparent difference between them. Complete relief of pain was obtained in seven of ten patients in each of the active treatment groups compared with only one of ten patients given placebo. No untoward events were observed in any patient.
D000328:Adult; D000368:Aged; D000700:Analgesics / Q000627:therapeutic use; D001241:Aspirin / Q000031:analogs & derivatives / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003085:Colic / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007660:Ketoprofen / Q000627:therapeutic use*; D007674:Kidney Diseases / Q000188:drug therapy*; D008239:Lysine / Q000031:analogs & derivatives / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010666:Phenylpropionates / Q000627:therapeutic use*
D000700:Analgesics; D010666:Phenylpropionates; D007660:Ketoprofen; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate