title: Adsorption characteristics of certain antibiotics to veegum and activated charcoal.
abstract: Adsorption of streptomycin sulphate and neomycin sulphate to veegum and activated charcoal in water or buffered solution was studied. Both antibiotics demonstrated a significant reduction in their activity, particularly in water. The activity of streptomycin sulphate decreased in the following order: veegum in water greater than activated charcoal in water greater than veegum in buffer greater than activated charcoal in buffer and their calculated adsorption coefficients were 111 X 10(-3), 57 X 10(-3), 33 X 10(-3) and 25 X 10(-3) (respectively), while neomycin sulphate was affected in the following decreasing order: activated charcoal in water greater than activated charcoal in buffer greater than veegum in water greater than veegum in buffer. The calculated adsorption coefficients were 64 X 10(-3), 47 X 10(-3), 34 X 10(-3) and 26 X 10(-3) (respectively). The mechanism of adsorption was discussed.
mesh_terms: D000327:Adsorption; D017607:Aluminum Compounds; D000538:Aluminum Silicates / Q000494:pharmacology*; D001412:Bacillus subtilis / Q000187:drug effects; D002606:Charcoal / Q000494:pharmacology*; D017616:Magnesium Compounds; D008826:Microbial Sensitivity Tests; D009355:Neomycin / Q000494:pharmacology*; D017640:Silicates; D013307:Streptomycin / Q000494:pharmacology*; D013816:Thermodynamics
chemical_list: D017607:Aluminum Compounds; D000538:Aluminum Silicates; D017616:Magnesium Compounds; D017640:Silicates; D002606:Charcoal; C033065:aluminum magnesium silicate; D009355:Neomycin; D013307:Streptomycin