Strain variation in interferon gamma production of BCG-sensitized mice challenged with PPD II. Importance of one major autosomal locus and additional sexual influences.
Interferon-gamma (IFN-gamma) production in BCG-sensitized mice challenged with PPD was examined in the sera from BALB/c and C57BL/6 mice. C57BL/6 mice produce about ten times more IFN-gamma than BALB/c mice. Studies on F1, F2, and backcross generations indicate that one partially dominant autosomal locus is involved. Furthermore, females consistently produce more IFN-gamma than males in all of these crosses, though the X chromosome cannot be held responsible for this.
D000818:Animals; D001500:BCG Vaccine / Q000009:adverse effects; D005260:Female; D007371:Interferon-gamma / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009929:Organ Size; D012737:Sex Factors; D013045:Species Specificity; D013154:Spleen / Q000033:anatomy & histology; D013163:Splenomegaly / Q000209:etiology; D014373:Tuberculin / Q000276:immunology*
D001500:BCG Vaccine; D014373:Tuberculin; D007371:Interferon-gamma