title: Enhanced Escherichia coli susceptibility to nitrofurantoin by EDTA and multiple aminoglycoside antibiotics resistance mutation.
abstract: Subinhibitory concentrations of ethylenediaminetetraacetic acid (EDTA) increased the susceptibility of Escherichia coli K12 multiple aminoglycoside antibiotics and nitrofurantoin-resistant mutants to aminoglycoside antibiotics (20- to 25-fold) and nitrofurantoin (15-fold). The same concentration of EDTA also increased the susceptibility of high-level nitrofurantoin-resistant mutants to nitrofurantoin. Aminoglycoside-resistant mutants with increased susceptibility to nitrofurantoin (2- to 3-fold) were selected with neomycin from E. coli nitrofurantoin-sensitive and resistant mutants. Decreased permeability of nitrofurantoin is inferred as one of the mechanisms of nitrofurantoin resistance.
mesh_terms: D004347:Drug Interactions; D004352:Drug Resistance, Microbial; D004492:Edetic Acid / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D009154:Mutation; D009355:Neomycin / Q000494:pharmacology*; D009582:Nitrofurantoin / Q000494:pharmacology*
chemical_list: D009582:Nitrofurantoin; D004492:Edetic Acid; D009355:Neomycin