Effects of indomethacin and naproxen on renal p-amino-hippurate (PAH) excretion in rats during postnatal development.
Effects of the cyclooxygenase inhibitors indomethacin and naproxen on renal PAH excretion were studied in volume-expanded and sodium-loaded, conscious rats of different ages. Indomethacin and naproxen reduce renal PAH excretion in 5- and 10-day-old rats but not in rats of older ages. Findings can be explained by a decrease in glomerular filtration rate. In addition, a competitive inhibition of PAH transport by the organic acids indomethacin and naproxen must be mentioned. Until now it is not known whether or not there is a direct or indirect influence of prostaglandins on processes involved in tubular PAH transport.
D000375:Aging; D000618:Aminohippuric Acids / Q000652:urine*; D000818:Animals; D004231:Diuresis / Q000187:drug effects; D005260:Female; D005919:Glomerular Filtration Rate; D006400:Hematocrit; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D009288:Naproxen / Q000494:pharmacology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism; D010130:p-Aminohippuric Acid / Q000652:urine*
D000618:Aminohippuric Acids; D009288:Naproxen; D012964:Sodium; D011451:Prostaglandin-Endoperoxide Synthases; D007213:Indomethacin; D010130:p-Aminohippuric Acid