Changes in the character of Factor VIII inhibitors following Factor VIII transfusion.
Factor VIII inhibitors from 4 haemophiliacs have been studied at intervals following transfusion of a factor VIII preparation with an aim to correlate their reaction kinetic and avidity with their immuno-chemical character. Post-treatment antibodies are more avid than pre-treatment antibodies and show a second order reaction while pre-treatment antibodies produce a graph of complex nature for the time course inactivation of Factor VIII. It seems that IgG3 anti VIII:C that forms a significant part of post-treatment antibody is responsible for these discrepancies.
D000915:Antibody Affinity; D000936:Antigen-Antibody Complex; D000941:Antigens / Q000032:analysis; D001803:Blood Transfusion; D005169:Factor VIII / Q000008:administration & dosage / Q000032:analysis / Q000037:antagonists & inhibitors* / Q000276:immunology; D006801:Humans; D007120:Immunochemistry; D009500:Neutralization Tests; D013997:Time Factors
D000936:Antigen-Antibody Complex; D000941:Antigens; D005169:Factor VIII