Hematologic and histologic experimental investigations on the therapeutic effect of leukotrophin.
The paper aims at evidencing the stimulating effect on hematopoietic stem cells exerted by the thymus extract "Leukotrophin", prepared by Ellem Laboratory, Milan, Italy. Investigation of the hematologic and histologic parameters allowed the follow up of alterations occurring in bone marrow, blood and tissues of the irradiated animals, treated and untreated as compared with the unirradiated and untreated controls. Regeneration was more active in the groups of animals irradiated and treated with Leukotrophin than in the irradiated and untreated controls. A maximal regeneration of the myeloid series, prevalently of the erythrocytic line, was found 9 days after irradiation.
D000818:Animals; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000528:radiation effects; D051379:Mice; D011830:Radiation Effects; D013154:Spleen / Q000528:radiation effects; D013949:Thymus Extracts / Q000494:pharmacology*; D013950:Thymus Gland / Q000528:radiation effects
D013949:Thymus Extracts; C024817:leukotrophin