[Age-dependent immunological parameters].
Lymphocyte stimulation, frequency of autoantibodies and concentration of immunoglobuline classes were investigated in 90 persons of 3 age-groups (5--15, 30--40 and 65--95 years of age). An age dependent decrease of MLC- and PhA-reactivity was observed. In contrast, the frequency of autoantibodies and the concentration of IgA increased with age. Individuals with a positive antinuclear factor demonstrated decreased IgA levels. No correlation between lymphocyte stimulation and autoantibody-frequency could be observed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D012217:Rheumatoid Factor / Q000032:analysis
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D012217:Rheumatoid Factor
Altersabhängige immunologische Parameter.