Induction of sister-chromatid exchanges and chromosome aberrations in human peripheral lymphocytes by 2,4,7-trinitro-9-fluorenone.
The genotoxicity of 2,4,7-trinitro-9-fluorenone (TNF) was investigated using the sister-chromatid exchange (SCE) and chromosome aberration assay systems with human peripheral lymphocytes. The SCE frequency increased from the control value of 9.45 to 27.80 (mean of 50 cells scored from each of two donors) after the lymphocytes were treated with the highest dose of TNF (3.0 microgram/ml). The results of the chromosome aberration experiment show that TNF induced more than a 4-fold increase in aberrations in each donor. The results, which indicate that TNF is clastogenic, add further evidence that this compound is potentially genotoxic to exposed populations.
D000964:Antimetabolites, Antineoplastic / Q000633:toxicity; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D005449:Fluorenes / Q000633:toxicity*; D006801:Humans; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects; D016685:Mitomycin; D008937:Mitomycins / Q000633:toxicity; D009152:Mutagenicity Tests; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D000964:Antimetabolites, Antineoplastic; D005449:Fluorenes; D008937:Mitomycins; D016685:Mitomycin; C005644:2,4,7-trinitrofluorenone