title: Contrasting roles of 5-hydroxytryptamine and noradrenaline in fever in rats.
abstract: 1. We have investigated the effects of endogenous monoamine depletion on the development of fever in rats. 2. Fever was produced in rats by a single intraperitoneal injection of Salmonella typhosa endotoxin or leucocyte pyrogen manufactured from ox blood. 3. Depletion of brain 5-hydroxytryptamine (5-HT) by pretreatment with p-chlorophenylalanine prevented the rise in rectal temperature produced both by bacterial endotoxin and by leucocyte pyrogen. 4. On the other hand depletion of noradrenaline (NA) by 6-hydroxydopamine pretreatment resulted in a potentiation of the fever produced by bacterial endotoxin. 5. These results suggest that 5-HT is involved in mechanisms responsible for the rise in temperature during fever and that NA is involved in mechanisms which serve to attenuate the rise.
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation; D004731:Endotoxins / Q000494:pharmacology; D010134:Fenclonine / Q000494:pharmacology; D005334:Fever / Q000139:chemically induced / Q000503:physiopathology*; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D012485:Salmonella typhi; D012701:Serotonin / Q000502:physiology*
chemical_list: D004731:Endotoxins; D006892:Hydroxydopamines; D012701:Serotonin; D010134:Fenclonine; D009638:Norepinephrine