title: [Regulators of differentiation in Streptomyces cyaneofuscatus].
abstract: Streptomyces cyaneofuscatus PRL 1642 producing valinomycin was shown to synthesize bioregulators of differentiation similar to A factor. The regulators stimulate spore formation and streptomycin synthesis in a Streptomyces griseus 1439 mutant deficient in A factor. Some S. cyaneofuscatus mutants respond to A factor addition into the medium by an increase in valinomycin synthesis and a change in morphological properties. The regulators from S. cyaneofuscatus are more effective toward mutants of this species than toward S. griseus mutants.
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives; D006133:Growth Substances / Q000096:biosynthesis* / Q000494:pharmacology; D009153:Mutagens / Q000494:pharmacology; D013171:Spores, Bacterial / Q000187:drug effects; D013302:Streptomyces / Q000187:drug effects / Q000378:metabolism*; D013305:Streptomyces griseus / Q000187:drug effects; D014157:Transcription Factors / Q000096:biosynthesis* / Q000494:pharmacology; D014634:Valinomycin / Q000032:analysis / Q000096:biosynthesis
chemical_list: D006133:Growth Substances; D009153:Mutagens; D014157:Transcription Factors; D014634:Valinomycin; C025035:A-factor (Streptomyces); D015107:4-Butyrolactone
vernacular_title: Reguliatory differentsiatsii Streptomyces cyaneofuscatus.