Hormonal changes and hair growth during treatment of hirsutism with cimetidine.
The effects on hair growth by treatment with cimetidine have been studied. This drug has been given orally to 4 women with simple hirsutism and 3 women with peptic ulcer as controls for a period of 9 months. Hair growth slowed down in all of the treated women but the results were not statistically significant. A significant decrease in urine 17-ketosteroids has been observed, while plasma levels of testosterone, 17-beta estradiol, progesterone, FSH, LH and prolactin, did not change substantially. It is concluded that, on the whole, cimetidine doses not seem to induce such results on hair growth as to claim a role in the treatment of hirsutism in other current regimes.
D015068:17-Ketosteroids / Q000652:urine; D000328:Adult; D002927:Cimetidine / Q000627:therapeutic use*; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006197:Hair / Q000254:growth & development*; D006628:Hirsutism / Q000188:drug therapy* / Q000378:metabolism; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood; D013739:Testosterone / Q000097:blood
D015068:17-Ketosteroids; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D002927:Cimetidine; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone