Interferon-gamma inhibits growth of Coxiella burnetii in mouse fibroblasts.
We studied the effects of various mouse interferon preparations on the growth of Coxiella burnetii in mouse fibroblasts. The addition of both recombinant interferon-gamma and a crude lymphokine preparation that contained interferon-gamma to infected L929 cells inhibited the growth of C. burnetii, whereas the addition of a crude preparation of type I interferons did not. Cycloheximide suppressed the inhibitory effects of recombinant interferon-gamma and crude lymphokines.
D000818:Animals; D002478:Cells, Cultured; D003381:Coxiella / Q000254:growth & development; D007370:Interferon Type I / Q000276:immunology; D007371:Interferon-gamma / Q000276:immunology*; D051379:Mice; D011778:Q Fever / Q000382:microbiology / Q000628:therapy*
D007370:Interferon Type I; D007371:Interferon-gamma