Ionophoric activity of the antibiotic X.14547 A in the mitochondrial membrane.
Release of Ca++, Mg++ and K+ by the carboxylic ionophore X-14547 A was studied in the mitochondrial membrane. A comparison was made with A.23187 ( Calcimycin ) and X.537 A (Lasalocid A) under the same experimental conditions. It was shown that in this test system X.14547 A is primarily a K+ carrier comparable with X.537 A.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism; D007192:Indenes / Q000494:pharmacology*; D007425:Intracellular Membranes / Q000187:drug effects*; D007476:Ionophores / Q000494:pharmacology*; D007832:Lasalocid / Q000494:pharmacology; D008274:Magnesium / Q000378:metabolism; D008928:Mitochondria / Q000187:drug effects*; D011188:Potassium / Q000378:metabolism
D000900:Anti-Bacterial Agents; D007192:Indenes; D007476:Ionophores; D000001:Calcimycin; C023605:X 14547-A; D008274:Magnesium; D011188:Potassium; D002118:Calcium; D007832:Lasalocid