title: Plasma cholesterol concentration and extra lipid band in monoclonal gammopathies.
abstract: Plasma lipids and lipoproteins were studied in 21 patients with benign monoclonal gammopathy, 21 patients with multiple myeloma and seven patients with Waldenström's macroglobulinaemia. Results were compared with those of a control group, age and sex matched. Low plasma cholesterol levels in all three patient groups were associated with low HDL-cholesterol concentrations. Apo A-I, but not apo B, was significantly reduced. Sixty per cent of the patients exhibited an extra lipid band on plasma lipoprotein electrophoresis, which could be an immunoglobulin-lipid complex. In these patients plasma and LDL-cholesterol levels were significantly lower than in those patients in whom this band was absent. No correlation was found between the severity of the disease and plasma lipid pattern.
mesh_terms: D000368:Aged; D001053:Apolipoproteins / Q000097:blood; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D001798:Blood Proteins / Q000032:analysis; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000097:blood*; D007136:Immunoglobulins; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000097:blood*; D014280:Triglycerides / Q000097:blood; D008258:Waldenstrom Macroglobulinemia / Q000097:blood*
chemical_list: D001053:Apolipoproteins; D001054:Apolipoproteins A; D001055:Apolipoproteins B; D001798:Blood Proteins; D008076:Cholesterol, HDL; D007136:Immunoglobulins; D008055:Lipids; D008075:Lipoproteins, HDL; C009823:M-proteins (Myeloma); D014280:Triglycerides; D002784:Cholesterol