Identification of the acid proteinase in human seminal fluid as a gastricsin originating in the prostate.
On the basis of a) kinetic data obtained with a synthetic substrate and two peptide inhibitors and b) immunological cross-reactivity, it is shown that the aspartic proteinase of human seminal fluid is a gastricsin. The source of the precursor (progastricsin) in the male genital tract is identified to be the prostate.
D016282:Aspartic Acid Endopeptidases; D010450:Endopeptidases / Q000032:analysis*; D006801:Humans; D008297:Male; D010434:Pepsin A / Q000032:analysis*; D011467:Prostate / Q000201:enzymology*; D012661:Semen / Q000201:enzymology*
D010450:Endopeptidases; D016282:Aspartic Acid Endopeptidases; D010434:Pepsin A; C020557:gastricsin