Changes of dopamine metabolism by hypoxia and effect of nootropic drugs.
An 18 h lasting moderate hypoxia equivalent to 7000 m altitude rises DOPAC level in the caudate nucleus and the mesolimbic area of the rat to about 130%. This elevation is counteracted by a singular high dose of nootropics of the "energy mobilizer" type, but not by vasoactive ones.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002421:Caudate Nucleus / Q000378:metabolism; D003975:Diazepam / Q000494:pharmacology; D004088:Dihydroergotoxine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D002504:Meclofenoxate / Q000494:pharmacology; D009963:Orotic Acid / Q000494:pharmacology; D010889:Piracetam / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D011746:Pyrithioxin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014748:Vinca Alkaloids / Q000494:pharmacology
D011619:Psychotropic Drugs; D014748:Vinca Alkaloids; D004088:Dihydroergotoxine; C013983:vinpocetine; D009963:Orotic Acid; D011746:Pyrithioxin; D002504:Meclofenoxate; D003975:Diazepam; D004298:Dopamine; D010889:Piracetam