Oxalate-induced encephalitic reactions to polyol-containing infusions during intensive care.
Fifteen of 5800 neuropathologically examined brains showed oxalosis with an intense inflammatory reaction comparable to ethylene glycol intoxication. All patients had received intensive care therapy with infusions of high amounts of xylitol, sorbitol, mannitol, or fructose, mostly together with glucose. The encephalitic reaction induced by calcium oxalate crystals was manifested by clinical symptoms of cerebral damage. A genetically fixed polyol intolerance is hypothesized to explain polyol-induced oxaloses in brain, kidney, and partly also in myocardium.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002129:Calcium Oxalate / Q000378:metabolism*; D003422:Critical Care; D004660:Encephalitis / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D005632:Fructose / Q000009:adverse effects; D005950:Glucose Solution, Hypertonic; D006801:Humans; D007263:Infusions, Parenteral; D007427:Intracranial Pressure / Q000187:drug effects; D008297:Male; D008353:Mannitol / Q000009:adverse effects*; D008875:Middle Aged; D013012:Sorbitol / Q000009:adverse effects*; D014993:Xylitol / Q000009:adverse effects*
D005950:Glucose Solution, Hypertonic; D002129:Calcium Oxalate; D005632:Fructose; D008353:Mannitol; D013012:Sorbitol; D014993:Xylitol