[Treatment of von Willebrand-Jürgens syndrome with "hepatitis-free" factor VIII concentrates].
In five patients with von Willebrand's disease the haemostatic effect of heat-treated factor VIII concentrates was examined. For comparison, small-pool cryoprecipitate was used. All three preparations (Factor VIII-HT Hyland, Factor VIII HS Behringwerke, Kryobulin SP) were shown to improve abnormal laboratory findings, especially bleeding time, and at times even normalize them. It was possible to prevent bleedings during operative procedures, and effectively treat spontaneous bleedings. Factor VIII-HT and Factor VIII HS could be used in dosages comparable to cryoprecipitate (20-40 U/kg); in patients undergoing surgery a dose interval of eight hours is recommended. Two of four patients suffering of chronic liver disease had raised transaminase activities after receiving Factor VIII-HT. Although the risk of hepatitis cannot be conclusively assessed, the preparations used provide, owing to their good blood-clotting effect, an advance in the treatment and prevention of serious complications in patients with von Willebrand's disease.
D000328:Adult; D001760:Bleeding Time; D002648:Child; D003450:Cryoglobulins / Q000627:therapeutic use; D005169:Factor VIII / Q000627:therapeutic use*; D005260:Female; D006470:Hemorrhage / Q000517:prevention & control; D006525:Hepatitis, Viral, Human / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control; D014842:von Willebrand Diseases / Q000188:drug therapy*
D003450:Cryoglobulins; C026040:cryobulin; D005169:Factor VIII
Behandlung des von-Willebrand-Jürgens-Syndroms mit "hepatitissicheren" Faktor-VIII-Konzentraten.