Normal thyroid function in desipramine nonresponders converted to responders by the addition of L-triiodothyronine.
The results of complete thyroid function testing were normal in four desipramine nonresponders who were converted to responders by addition of L-triiodothyronine (T3). These findings suggest that the effectiveness of T3 is not due to correction of subtle thyroid deficiencies.
D000328:Adult; D003866:Depressive Disorder / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D003891:Desipramine / Q000494:pharmacology / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000503:physiopathology; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000494:pharmacology / Q000627:therapeutic use*
D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine; D003891:Desipramine