title: Does trypsin extract soluble antigen meet the criteria of immunogenicity without allergenicity?
abstract: We were unable to confirm the finding of Crowle that TESA possesses the attribute of immunogenicity and absence of allergenicity which are desired in a non-living antituberculosis vaccine. This disagreement could be a function of the particular lot of TESA examined and/or differences in the animal test systems used for the assay of protective potency. The relative contribution of these two possibilities could be determined by the simultaneous assay of a potent TESA product in different laboratories using different animal models.
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D005260:Female; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D008297:Male; D009163:Mycobacterium bovis; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D014357:Trypsin; D014376:Tuberculosis / Q000517:prevention & control*; D014612:Vaccines / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D014612:Vaccines; D014357:Trypsin