[Changes in the glomerular filtration barrier during aging in rats].
In this work, we analysed histochemical, biochemical and functional modifications of the glomerular basement membrane (GBM), occurring for aging, in the Rat. The results suggest an increase of collagenous components and a decrease of sulfated glucosaminoglycans as a function of age. In other respects, fixed anionic sites of the GBM, disclosed by colloidal iron, are almost exclusively restricted to the laminae rarae in one month-old rats, whereas the marker appears randomly scattered among the lamina densa in 12 month-old animals. These changes could be the cause of increased permeability of the GBM during aging.
D000375:Aging; D000818:Animals; D001485:Basement Membrane / Q000503:physiopathology; D002463:Cell Membrane Permeability; D003094:Collagen / Q000032:analysis; D005260:Female; D006651:Histocytochemistry; D007678:Kidney Glomerulus / Q000503:physiopathology*; D008297:Male; D011507:Proteinuria / Q000503:physiopathology; D051381:Rats
D003094:Collagen
Modifications de la barrière de filtration glomérulaire au cours du vieillissement, chez le rat.