The influence of memantine on the anticonvulsant effects of the antiepileptic drugs.
1,3-Dimethyl-5- aminoadamantine ( DMAA , D-145, memantine ( Memantine ) has anticonvulsant properties and potentiates the actions of phenytoin, carbamazepine, diazepam, clonazepam and valproic acid in the electrogenic convulsion tests on mice.
D000547:Amantadine / Q000031:analogs & derivatives*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002220:Carbamazepine / Q000494:pharmacology; D002998:Clonazepam / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004357:Drug Synergism; D004597:Electroshock; D008297:Male; D008559:Memantine / Q000494:pharmacology*; D051379:Mice; D010672:Phenytoin / Q000494:pharmacology; D014635:Valproic Acid / Q000494:pharmacology
D000927:Anticonvulsants; D002220:Carbamazepine; D002998:Clonazepam; D014635:Valproic Acid; D010672:Phenytoin; D000547:Amantadine; D003975:Diazepam; D008559:Memantine