title: The comparative distribution of xenopsin- and neurotensin-like immunoreactivity in Xenopus laevis and rat tissues.
abstract: The regional distribution of xenopsin-like immunoreactivity (XPLI) and of neurotensin-like immunoreactivity (NTLI) was studied by radioimmunoassay in tissues of Xenopus laevis and rat. In Xenopus laevis, XPLI showed a wide distribution throughout central and peripheral tissues with the highest concentration in the skin; NTLI was found in both central and peripheral tissues with the exception of the skin. Gel chromatography on Sephadex G-25 was used in order to characterize the immunoreactive material; both XPLI and NTLI eluted in a single peak at the position of synthetic xenopsin and neurotensin. No XPLI could be detected in central and peripheral tissues from mouse, rat, guinea-pig, rabbit or cat. In contrast, NTLI was found in a variety of peripheral tissues of the rat and it coeluted with synthetic neurotensin on reverse phase high-performance liquid chromatography. It is probably present in preganglionic parasympathetic nerve fibres.
mesh_terms: D000818:Animals; D002211:Capsaicin / Q000494:pharmacology; D003429:Cross Reactions; D005260:Female; D006321:Heart / Q000187:drug effects; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D009496:Neurotensin / Q000032:analysis*; D009842:Oligopeptides / Q000032:analysis*; D016627:Oxidopamine; D010455:Peptides; D011863:Radioimmunoassay / Q000379:methods; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D014018:Tissue Distribution; D014981:Xenopus; D029867:Xenopus Proteins
chemical_list: D006892:Hydroxydopamines; D009842:Oligopeptides; D010455:Peptides; D029867:Xenopus Proteins; D009496:Neurotensin; C016832:xenopsin; D016627:Oxidopamine; D002211:Capsaicin