Occupational asthma due to pepsin.
A 30-year-old atopic worker exposed to pepsin powder, herb, and pollen extracts at work developed an increase in asthmatic symptoms. Monitoring of peak expiratory flow rate revealed more important fluctuations at work. Skin prick tests yielded a large immediate reaction to pepsin. Specific inhalation challenges confirmed the diagnosis; an intense early response was documented after exposure to pepsin. The pepsin IgE RAST was positive and selectively inhibited by pepsin.
D000328:Adult; D001249:Asthma / Q000139:chemically induced*; D001985:Bronchial Provocation Tests; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis / Q000276:immunology; D006969:Hypersensitivity, Immediate / Q000175:diagnosis / Q000276:immunology; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced*; D010366:Peak Expiratory Flow Rate; D010434:Pepsin A / Q000009:adverse effects*; D011208:Powders; D012882:Skin Tests
D011208:Powders; D010434:Pepsin A