Biological significance of nonlymphocytic oligoblastic leukemia. Cytokinetic behavior of dividing granulocytic precursors in 11 patients.
Kinetic studies of marrow dividing granulocytic precursors (mitotic index and flash labeling index with 3H-TDR) were carried out in 11 patients with oligoblastic leukemia (OBL). The results were compared with similar data from cases of conventional acute non-lymphocytic leukemia (ANLL). The cytokinetic results were as follows: MI (%) in OBL, mean = 0.75; MI (%) in ANLL, mean = 0.66; p greater than 0.7; LI (%) in OBL, mean = 15.0; LI (%) in ANLL, mean = 15.4, p greater than 0.7. The lack of cytokinetic differences between these two groups of patients stands in favor of the hypothesis that OBL might represent a special type of smoldering leukemia with a 'plateau' of blast cell accumulation established at a subleukemic level.
D000368:Aged; D002455:Cell Division; D005260:Female; D006098:Granulocytes / Q000166:cytology*; D006801:Humans; D007938:Leukemia / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D013234:Stem Cells / Q000166:cytology*