Brain monoamine oxidase in suckling rabbits treated with organophosphorus compound. I. Acute intoxication.
In 16-day-old rabbits treated with dichlorvos 8 mg/kg per os the activity of monoamine oxidase A form (MAO A) in brain was studied. A short-lasting decrease of brain MAO A was followed by a recovery of enzyme activity within 120 min. In parallel to changes in MAO A activity breathing disturbances were observed. It is concluded that the decrease of MAO A was due rather to hypoxia than to a direct effect of dichlorvos. In 16-day-old rabbits clorgyline (2 mg/kg) and tranylcypromine (10 mg/kg) were potent inhibitors of MAO A but deprenyl and pargyline were ineffective.
D000828:Animal Population Groups / Q000378:metabolism*; D000818:Animals; D000833:Animals, Suckling / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D003010:Clorgyline / Q000494:pharmacology*; D004006:Dichlorvos / Q000494:pharmacology; D008995:Monoamine Oxidase / Q000378:metabolism*; D062025:Organophosphate Poisoning; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010275:Parasympathetic Nervous System / Q000187:drug effects; D010293:Pargyline / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology*; D011817:Rabbits; D012642:Selegiline / Q000494:pharmacology; D014191:Tranylcypromine / Q000494:pharmacology; D014202:Tremor / Q000139:chemically induced
D009943:Organophosphorus Compounds; D011437:Propylamines; D012642:Selegiline; D014191:Tranylcypromine; D004006:Dichlorvos; D010293:Pargyline; D008995:Monoamine Oxidase; D003010:Clorgyline