Carbonic anhydrase II isoenzyme in rat liver is under hormonal control.
A specific and sensitive radioimmunoassay for rat carbonic anhydrase II (CAII) was developed. Rat livers were perfused with Ringer's solution and the hepatic CAII was measured. Concentrations of CAII in female liver were significantly higher than those in male liver. Castration increased the concentration in male liver, though not to that in females, and diethylstilboestrol treatment of castrated males gave values higher than those in females.
D000818:Animals; D002256:Carbonic Anhydrases / Q000378:metabolism*; D002369:Castration; D004054:Diethylstilbestrol / Q000494:pharmacology*; D013196:Dihydrotestosterone / Q000494:pharmacology*; D005260:Female; D007527:Isoenzymes / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D007527:Isoenzymes; D013196:Dihydrotestosterone; D004054:Diethylstilbestrol; D002256:Carbonic Anhydrases