Synapsin I in nerve terminals: selective association with small synaptic vesicles.
Immunocytochemistry revealed that synapsin I is preferentially (and possibly exclusively) associated with small (40- to 60-nanometer) synaptic vesicles and not with large (greater than 60-nanometer) dense-core vesicles in bovine hypothalamus. These observations may explain why synapsin I is found exclusively in neurons, since small synaptic vesicles are specific to neurons whereas large dense-core vesicles in neurons may be considered the equivalent of secretory organelles in endocrine cells.
D000818:Animals; D002417:Cattle; D007031:Hypothalamus / Q000378:metabolism; D007118:Immunoassay; D008854:Microscopy, Electron; D009411:Nerve Endings / Q000378:metabolism*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D016704:Synapsins; D013572:Synaptic Vesicles / Q000378:metabolism*; D013574:Synaptosomes / Q000032:analysis
D009419:Nerve Tissue Proteins; D016704:Synapsins