title: Central depressant action of cesium in mice.
abstract: Cesium chloride (CsCl) at several dose levels (1.25-20.0 mEq/kg IP) was administered acutely to albino mice whose behavior was compared with that in corresponding saline controls. Motor activity decreased and Straub tail occurred in a dose-related manner. Signs of autonomic disturbance, diarrhea, and salivation were seen with toxic doses. Subchronic administration of CsCl (5.0 mEq/kg/day IP for 7 days) exerted a phenothiazine-like effect in mice, reducing amphetamine-induced aggregation toxicity and enhancing pentobarbital-induced hypnosis. The antinociceptive action of morphine was unaltered by identical multiple administrations of CsCl. These results indicate a specific neurosuppressant action of CsCl on mouse CNS and suggest exploration of this alkali earth metal for antipsychotic-like activity.
mesh_terms: D000661:Amphetamine / Q000633:toxicity; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002492:Central Nervous System Depressants; D002586:Cesium / Q000494:pharmacology* / Q000633:toxicity; D003441:Crowding; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology; D012472:Salivation / Q000187:drug effects; D012890:Sleep / Q000187:drug effects; D014554:Urination / Q000187:drug effects
chemical_list: D002492:Central Nervous System Depressants; D002586:Cesium; D000661:Amphetamine; D010424:Pentobarbital