Mycosis fungoides and lymphoplasmacytoid immunocytoma in the same patient. A case report.
The simultaneous occurrence of two different lymphomas in a 57-year-old white woman is reported: mycosis fungoides and a leukemic lymphoplasmacytoid immunocytoma. The first was confirmed by histologic study and electron microscopy, and the latter by histologic study and immunoperoxidase staining. The lymphoid cells in the involved bone marrow and peripheral blood expressed the same surface immunoglobulin as was found in the cytoplasm of the immunocytoma cells, i.e., IgM-lambda. The clonal B-cell expansion was brought into a lasting remission by chlorambucil, but the cutaneous lymphoma proved to be refractory to therapy. The patient died 38 months after diagnosis.
D002699:Chlorambucil / Q000627:therapeutic use; D003593:Cytoplasm / Q000276:immunology; D005260:Female; D006403:Hematologic Tests; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology; D008214:Lymphocytes / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D009378:Neoplasms, Multiple Primary / Q000276:immunology*; D011701:PUVA Therapy; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012878:Skin Neoplasms / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*
D007075:Immunoglobulin M; D007146:Immunoglobulin lambda-Chains; D011947:Receptors, Antigen, B-Cell; D002699:Chlorambucil