[The mutagenicity evaluation of MT-141, a new cephamycin].
Mutagenicity of MT-141, a new cephamycin, was evaluated by in vitro and in vivo assays. MT-141 did not induce mutations of the test strains, Escherichia coli WP2 (uvr A) and Salmonella typhimurium TA1535, TA1537, TA1538, TA100 and TA98, with and without metabolic activation in vitro. In bone marrow micronucleus assay with male mice, MT-141 showed no induction of micronucleated polychromatic erythrocyte at 6 hours and 30 hours after administration. In addition MT-141 was found not to cause any dominant lethal effects on male mice for 8 weeks after administration.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects; D002511:Cephalosporins / Q000633:toxicity*; D002513:Cephamycins / Q000633:toxicity*; D004906:Erythrocyte Count; D004912:Erythrocytes / Q000187:drug effects; D004926:Escherichia coli / Q000235:genetics; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D011247:Pregnancy; D012486:Salmonella typhimurium / Q000235:genetics
D002511:Cephalosporins; D002513:Cephamycins; D009153:Mutagens; C046079:cefminox