A comparison of three affected-sib-pair scoring methods to detect HLA-linked disease susceptibility genes.
Two widely used affected-sib-pair scoring procedures (the Green and Woodrow [1977] procedure, and the method of forming all possible affected-sib-pairs) are compared with a new method for their relative efficiency in detecting the presence of an HLA-linked disease susceptibility gene. Their relative performance is investigated by extensive computer simulations over a large number of disease transmission models. On the average, the new procedure appears to outperform the Green and Woodrow method and the "all-possible-pairs" method.
D003201:Computers; D004198:Disease Susceptibility; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D006683:HLA-DQ Antigens; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D010375:Pedigree; D010641:Phenotype
D006683:HLA-DQ Antigens; D000949:Histocompatibility Antigens Class II