[Effect of calcium ionophore (A23187) on the production of thromboxane B2 in human polymorphonuclear cells in vitro].
Polymorphonuclear leukocytes (PMN) are capable to produce prostaglandins in vivo and in vitro, and thromboxane B2 (TXB2) which is the main metabolite of arachidonic acid in these cells. In the present work we studied, with radioimmunoassay method, the effect of calcium ionophore A23187 on PMN. This substance is capable to stimulate TXB2 release by PMN and its effect is inhibited by indomethacin.
D000001:Calcimycin / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D011863:Radioimmunoassay; D013929:Thromboxane B2 / Q000097:blood*; D013931:Thromboxanes / Q000097:blood*
D013931:Thromboxanes; D000001:Calcimycin; D013929:Thromboxane B2; D007213:Indomethacin
Effetto del calcio ionoforo (A23187) sulla produzione di trombossano B2 in polimorfonucleati umani in vitro.