title: Genetic polymorphism of thyroxin-binding globulin (TBG) in the Pacific area.
abstract: Human plasma samples, radiolabeled with [125I]thyroxin, from the Asian, Pacific, and Australian area have been subjected to isoelectric focusing to reveal genetic variation in thyroxin-binding globulin (TBG). A genetically determined electrophoretic slow variant, TBG S, indistinguishable from the variant found in black Africans, has been observed with a frequency of 1%-10% in all Melanesian and Polynesian populations studied. The TBG S variant is present also with low frequency in Micronesians and in some Indonesian populations. However, East Asians, Indians, and Australian Aborigines were found to be monomorphic.
mesh_terms: D001315:Australia; D004591:Electrophoresis, Polyacrylamide Gel; D005006:Ethnicity; D005202:Asia, Eastern; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007194:India; D007525:Isoelectric Focusing; D008297:Male; D010139:Pacific Islands; D010641:Phenotype; D011110:Polymorphism, Genetic; D013975:Thyroxine-Binding Proteins / Q000235:genetics*
chemical_list: D013975:Thyroxine-Binding Proteins