title: [Chromosomal changes in evolution and in pathology: analysis of pericentric inversions].
abstract: The great similarities between pericentric inversions observed in human pathology, having occurred during evolution, or radio-induced in human cells, indicate that they do not occur at random. About 1/3rd to 1/4th of these chromosomal rearrangements are capable to induce abnormal progeny after aneusomy of recombination, during meiosis.
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002869:Chromosome Aberrations / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D025063:Chromosome Disorders; D007446:Chromosome Inversion; D002875:Chromosomes / Q000528:radiation effects; D003037:Cobalt Radioisotopes / Q000009:adverse effects; D006801:Humans; D011323:Primates
chemical_list: D003037:Cobalt Radioisotopes
vernacular_title: Modifications chromosomiques dans l'évolution et en pathologie: analyse des inversions péricentriques.