Influence of D,L-ethionine intoxication on galactosyl transferase activity and morphology of the rat liver Golgi apparatus.
Eight hours after single, intraperitoneal injection of D,L-ethionine to rats, statistically significant increased activity of liver Golgi apparatus UDP-Gal-GlcNAc transferase calculated per g as well as per total liver in comparison with control was found. Specific activity of the enzyme was higher than normal, however not statistically significant. Yield of Golgi-rich membrane fraction was unchanged in comparison with control. Slight stimulation of liver Golgi apparatus expressed in increased area of this organelle and marginal dilatation of dictyosome cisternae and secretory vacuoles were found in morphological analysis performed in electron microscope.
D000818:Animals; D005001:Ethionine / Q000633:toxicity*; D005260:Female; D006056:Golgi Apparatus / Q000187:drug effects*; D007788:Lactose Synthase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D009237:N-Acetyllactosamine Synthase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D007788:Lactose Synthase; D009237:N-Acetyllactosamine Synthase; D005001:Ethionine