[Bolus injection, short infusion or intravenous drip of aminoglycoside antibiotics? In vivo study with netilmicin and Pseudomonas aeruginosa].
The efficacy of various dosage schedules of netilmicin against Pseudomonas aeruginosa has been compared using an in vivo model (normal and granulocytopenic mice). Bolus injections were at least as effective as simulated short infusions or simulated continuous infusions of identical total amounts of netilmicin.
D000380:Agranulocytosis / Q000188:drug therapy; D000818:Animals; D003692:Delayed-Action Preparations; D004195:Disease Models, Animal; D005839:Gentamicins / Q000008:administration & dosage*; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D051379:Mice; D009428:Netilmicin / Q000008:administration & dosage* / Q000627:therapeutic use; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000187:drug effects
D003692:Delayed-Action Preparations; D005839:Gentamicins; D009428:Netilmicin
Bolusinjektion, Kurzinfusion oder Dauer-infusion von Aminoglykosid-Antibiotika? In-vivo-Studie mit Netilmicin und Pseudomonas aeruginosa.