title: [Early detection and determination of the incidence of side effects in the hospital by intensive (comprehensive) drug monitoring].
abstract: In the "Comprehensive Hospital Drug Monitoring Berne" (CHDMB) the frequency of adverse drug reactions can be either determined by counting individual patients with probable or proven reactions to a drug or by mathematic-statistical analysis of exposed and nonexposed patients with and without the reaction. These two methods are used to show the frequency of a maculopapular rash in connection with three antiinfectious drugs. The mathematic-statistical frequency of a maculopapular rash was 11.0% for aminopenicillins, 3.7% for other penicillins, and 3.4% for co-trimoxazole and sulfonamides compared to 1.2% in patients treated with other than the especially mentioned drug groups. Two new adverse reactions were detected by this system: arterial hypotension due to novaminesulfon-dipyrone (Novalgin) and drug fever to the antidepressive drug nomifensin (Alival). Also the frequency of some other, not unusual adverse reactions is demonstrated.
mesh_terms: D000890:Anti-Infective Agents / Q000009:adverse effects; D003875:Drug Eruptions / Q000453:epidemiology; D004341:Drug Evaluation / Q000379:methods; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D010607:Pharmacy Service, Hospital / Q000458:organization & administration*; D013223:Statistics as Topic; D013557:Switzerland
chemical_list: D000890:Anti-Infective Agents
vernacular_title: Früherfassung und Bestimmung der Häufigkeit von Nebenwirkungen im Spital durch intensives (komprehensives) Drug Monitoring.