[Effects of dichloroacetate and 2-chloropropionate on carbohydrate metabolism of isolated hepatocytes. Therapeutic applications].
In isolated hepatocytes, dichloroacetate directly activates pyruvate dehydrogenase whereas its biotransformation product, oxalate, inhibits pyruvate carboxylase and pyruvate kinase. Dichloroacetate, which decreases blood lactate very efficiently, has been sucessfully tested in the acute treatment of congenital lactic acidosis, but its transformation into oxalate and potential chronic toxicity prompt to replace it by 2-chloropropionate as a therapeutic agent.
D000085:Acetates / Q000494:pharmacology*; D000138:Acidosis / Q000188:drug therapy; D000818:Animals; D050260:Carbohydrate Metabolism; D003999:Dichloroacetic Acid / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D005947:Glucose / Q000378:metabolism; D049673:History, 20th Century; D006843:Hydrocarbons, Chlorinated; D066298:In Vitro Techniques; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008722:Methods; D011422:Propionates / Q000494:pharmacology*; D011766:Pyruvate Carboxylase / Q000378:metabolism; D051381:Rats
D000085:Acetates; D006843:Hydrocarbons, Chlorinated; D011422:Propionates; D003999:Dichloroacetic Acid; C021974:2-chloropropionic acid; D011766:Pyruvate Carboxylase; D005947:Glucose
Etude des effets du dichloroacétate et du 2-chloropropionate sur le métabolisme glucidique de l'hépatocyte isolé. Applications thérapeutiques.