title: Problems involved in correlating changes of functional diffusive and anatomical surface areas of the upper and lower chicken small intestine during fasting.
abstract: The anatomic villous surface area and the functional diffusive area (measured by the absorption of 64 mM thiourea) of the jejunum and ileum was estimated in fed and 3-d-fasted chickens. In the jejunum, fasting caused a 50% reduction of the anatomic villous surface area but only a 32% reduction in the functional diffusive area. The jejunal permeability to thiourea was unaltered. The ileal anatomic villous surface area was unaffected by fasting but the ileal functional diffusive area was decreased significantly by 26%, concomitant with a significant reduction of 34% in the permeability to thiourea. The passive absorption of thiourea cannot be used as a simple index of the functional diffusive surface area for dietary-induced changes in the small intestine of the domestic fowl.
mesh_terms: D000818:Animals; D002645:Chickens / Q000033:anatomy & histology*; D004058:Diffusion; D005215:Fasting; D005260:Female; D007082:Ileum / Q000033:anatomy & histology* / Q000378:metabolism; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000033:anatomy & histology; D007583:Jejunum / Q000033:anatomy & histology* / Q000378:metabolism; D008871:Microvilli; D013890:Thiourea / Q000378:metabolism
chemical_list: D013890:Thiourea