Effect of long-term starvation on acetate and ketone body metabolism in obese patients.
The turnover of ketone bodies and acetate was evaluated as well from the disappearance rate of (3-14C)acetoacetate or (1-14C)acetate respectively as from the conversion of FFA into these metabolites in normal weight and obese overnight-fasted and in obese long-term starved patients. The disappearance rate of (1-14C)oleate was the same in all three groups. Long-term starvation enhanced ketone body turn-over almost 10-fold, whereas the disappearance rate for ketone bodies decreased from 0.035 to 0.015 min-1. Under the same circumstances the turnover of acetate was about 1 mumol g-1 min-1 accounting for about 5% of FFA turnover. Long-term starvation decreased the conversion of (1-14C)oleate into triglycerides by almost 50% and increased the (2-C)-(4-C)/(1-C) ratio of radioactivity in ketone bodies. The reincorporation of radioactivity from the (1-C)position of (1-14C)oleate into the ( (2-C)-(n-C) ) position of FFA, which is a measure of the reutilization of acetyl-CoA for FFA synthesis decreased significantly during long-term starvation.
D020155:3-Hydroxybutyric Acid; D000085:Acetates / Q000378:metabolism*; D019342:Acetic Acid; D000090:Acetoacetates / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D007657:Ketone Bodies / Q000378:metabolism*; D007700:Kinetics; D008055:Lipids / Q000097:blood; D009765:Obesity / Q000378:metabolism*; D019301:Oleic Acid; D009829:Oleic Acids / Q000378:metabolism; D013217:Starvation; D014280:Triglycerides / Q000097:blood
D000085:Acetates; D000090:Acetoacetates; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D007657:Ketone Bodies; D008055:Lipids; D009829:Oleic Acids; D014280:Triglycerides; D019301:Oleic Acid; C016635:acetoacetic acid; D019342:Acetic Acid; D020155:3-Hydroxybutyric Acid