Alterations in local blood flow and tissue-gas tension caused by epinephrine.
Subcutaneous injection of epinephrine markedly reduced local tissue pO2 levels and blood flow while increasing tissue pCO2 in a rat model. The duration and magnitude of these effects were correlated with prolonged elevation of tissue levels of epinephrine and were proportional to the amount of epinephrine injected.
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D007279:Injections, Subcutaneous; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects*; D013997:Time Factors; D014018:Tissue Distribution
D002245:Carbon Dioxide; D010100:Oxygen; D004837:Epinephrine