The influence of various precursors on the concentration of energy-rich phosphates and pyridine nucleotides in cardiac tissue and its possible meaning for anoxic survival.
A special "anoxia test" was developed with isolated guinea pig atria to test influences on the anoxic energy balance. Adenine, ribose, nicotinic acid or nicotinamide added as precursors to nutrition solutions inhibit the loss of cardiac adenine and pyridine nucleotides during anoxia and improve the energy balance under aerobic and anaerobic conditions in the myocardium.
D000225:Adenine / Q000494:pharmacology; D000332:Aerobiosis; D000818:Animals; D005947:Glucose / Q000378:metabolism; D006168:Guinea Pigs; D000860:Hypoxia / Q000378:metabolism*; D009200:Myocardial Contraction; D009206:Myocardium / Q000378:metabolism*; D009243:NAD / Q000378:metabolism*; D009536:Niacinamide / Q000494:pharmacology; D010710:Phosphates / Q000378:metabolism*
D010710:Phosphates; D009243:NAD; D009536:Niacinamide; D005947:Glucose; D000225:Adenine