Dopaminergic modulation of the adenohypophyseal reaction to oestradiol: interaction of perphenazine with the thyroid hormones.
In male and female rats, oestradiol raises adenohypophyseal weight, the thyroxine-binding capacity of the adenohypophyseal proteins and the blood ceruloplasmin (polyphenol oxidase) level and reduces the ascorbic acid concentration in the hypothalamus. Simultaneous administration of the thyroid hormones inhibits all these reactions. The simultaneous administration of perphenazine (a dopaminergic neurone inhibitor) potentiates the adenohypophyseal and ceruloplasmin reaction, but does not modify the hypothalamic ascorbic acid reaction. Perphenazine combined with the thyroid hormones blocks the latters' inhibitory effect on the adenohypophyseal, ceruloplasmin and hypothalamic ascorbic acid reaction to oestradiol. The possible mechanisms by which perphenazine blocks the inhibitory effect of the thyroid hormones are discussed.
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D002570:Ceruloplasmin / Q000032:analysis; D004298:Dopamine / Q000502:physiology*; D018492:Dopamine Antagonists; D004347:Drug Interactions; D004958:Estradiol / Q000494:pharmacology / Q000502:physiology*; D005260:Female; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010546:Perphenazine / Q000494:pharmacology*; D010903:Pituitary Gland, Anterior / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D013963:Thyroid Hormones / Q000494:pharmacology*; D013974:Thyroxine / Q000378:metabolism
D018492:Dopamine Antagonists; D013963:Thyroid Hormones; D004958:Estradiol; D002570:Ceruloplasmin; D010546:Perphenazine; D001205:Ascorbic Acid; D013974:Thyroxine; D004298:Dopamine