[Effect of epidermal chalones on induction and growth of tumors of the cervicovaginal epithelium of mice].
Tumors of the cervicovaginal epithelium were induced in BALB/c female mice with local application of dimethylbenzanthra cene. In the course of inducing tumors or after their appearance the mice were treated intravaginally with 55-81% ethanolic extract of the rat skin or liver (control) containing 1% chalones. The skin extract rather than liver one delays slightly the growth and incidence of cervical and vaginal tumours, and increases the survival of animals.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors; D000230:Adenocarcinoma / Q000517:prevention & control; D000818:Animals; D000970:Antineoplastic Agents; D002278:Carcinoma in Situ / Q000517:prevention & control; D002294:Carcinoma, Squamous Cell / Q000517:prevention & control; D004817:Epidermis / Q000032:analysis; D005260:Female; D006131:Growth Inhibitors / Q000032:analysis / Q000627:therapeutic use*; D008099:Liver / Q000032:analysis; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control; D051381:Rats; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D014625:Vaginal Neoplasms / Q000139:chemically induced / Q000517:prevention & control*
D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D015127:9,10-Dimethyl-1,2-benzanthracene
Vliianie épidermal'nykh keĭlonov na induktsiiu i rost opukholeĭ tservikovaginal'nogo épiteliia u mysheĭ.