Tissue pO2 and pCO2 in the gastrointestinal tract and liver during intravenous vasopressin infusion. An experimental study in pigs.
Tissue pO2 and pCO2 were measured in the oesophagus, stomach, small and large bowel and liver of piglets before, during and after a 30-min infusion of vasopressin (2.75 mU/kg/min). For registration of the tissue gas tensions a silicone elastomer tube was used as a tonometer. Systemic arterial and portal blood gas analyses were performed. Plasma lactate was estimated. Cardiac output and portal vein and hepatic artery blood flow were registered. Vasopressin infusion caused significant fall in the tissue pO2 and increase in the pCO2 throughout the gastrointestinal tract. The liver pO2 also decreased, but no change in the liver pCO2 was found. Serum lactic acid increased. There seems to be risk of hypoxic lesion in all parts of the gastrointestinal tract during vasopressin infusion.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000378:metabolism*; D002302:Cardiac Output / Q000187:drug effects; D004064:Digestive System / Q000187:drug effects*; D007773:Lactates / Q000097:blood; D008099:Liver / Q000098:blood supply / Q000187:drug effects*; D010100:Oxygen / Q000378:metabolism*; D010313:Partial Pressure; D013552:Swine; D014667:Vasopressins / Q000494:pharmacology*
D007773:Lactates; D014667:Vasopressins; D002245:Carbon Dioxide; D010100:Oxygen