title: Interferon-gamma inhibits growth of Coxiella burnetii in mouse fibroblasts.
abstract: We studied the effects of various mouse interferon preparations on the growth of Coxiella burnetii in mouse fibroblasts. The addition of both recombinant interferon-gamma and a crude lymphokine preparation that contained interferon-gamma to infected L929 cells inhibited the growth of C. burnetii, whereas the addition of a crude preparation of type I interferons did not. Cycloheximide suppressed the inhibitory effects of recombinant interferon-gamma and crude lymphokines.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003381:Coxiella / Q000254:growth & development; D007370:Interferon Type I / Q000276:immunology; D007371:Interferon-gamma / Q000276:immunology*; D051379:Mice; D011778:Q Fever / Q000382:microbiology / Q000628:therapy*
chemical_list: D007370:Interferon Type I; D007371:Interferon-gamma