Intrinsic activity of the benzodiazepine antagonist Ro 15-1788 in man: an electrophysiological investigation.
Ten healthy volunteers were injected i.v. with 5 mg Ro 15-1788, a specific benzodiazepine antagonist, or placebo in a double-blind randomised design. In the EEG, Ro 15-1788 led--with some topographical variations--to a diminution of theta and alpha power, an increase of alpha mean frequency and a decrease of delta mean frequency. In auditory evoked potentials, the N1P2 and P2N2 amplitudes decreased. The electrophysiological changes induced by Ro 15-1788 are consistent with a central stimulant action. Ro 15-1788 induced some slight behavioural and subjective changes.
D000328:Adult; D001143:Arousal / Q000187:drug effects; D001570:Benzodiazepinones / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D005133:Eye Movements / Q000187:drug effects; D005260:Female; D005442:Flumazenil; D006801:Humans; D008297:Male
D001570:Benzodiazepinones; D005442:Flumazenil