[Comparative study of the levels of anticonvulsants and their free fractions in venous blood, saliva and capillary blood in man].
There is a good correlation for the six anticonvulsants studied in mono and polytherapy in human serous and capillary blood. Blood can be taken either at the vein, or at the finger. The ratio free fraction and saliva/serous blood has given for phenobarbital 0.65 (0.52 - 0.83) and 0.30 (0.21 - 0.46), pH 5.9 - 7.5, phenytoin 0.11 (0.10 - 0.11) and 0.12 (0.08 - 0.23), primidone 0.81 (0.74 - 0.83) and 1.03 (0.88 - 1.11), carbamazepine 0.22 (0.20 - 0.26) and 0.37 (0.30 - 0.50), ethosuximide 0.99 (0.81 - 7.01) and 0.95 (0.90 - 1.30), and less than 0.10 for valproate levels. In certain conditions, saliva may have a considerable place in drug monitoring.
D000927:Anticonvulsants / Q000097:blood / Q000378:metabolism*; D001711:Biotransformation; D002220:Carbamazepine / Q000378:metabolism; D005013:Ethosuximide / Q000378:metabolism; D006801:Humans; D010634:Phenobarbital / Q000378:metabolism; D010672:Phenytoin / Q000378:metabolism; D011324:Primidone / Q000378:metabolism; D012463:Saliva / Q000378:metabolism*; D014635:Valproic Acid / Q000378:metabolism
D000927:Anticonvulsants; D011324:Primidone; D002220:Carbamazepine; D005013:Ethosuximide; D014635:Valproic Acid; D010672:Phenytoin; D010634:Phenobarbital
Etude comparative des taux d'anticonvulsivants et de leurs fractions libres dans le sérum veineux, la salive et le sérum capillaire chez l'homme.