Comparison of the antacid properties of almagate and aluminium hydroxide against pentagastrin-induced gastric secretion in healthy volunteers.
The potency of a new antacid, almagate (hydrated aluminium-magnesium hydroxycarbonate, Al2Mg6 (OH)14(CO3)2 X 4 H2O, Almax) has been compared with that of aluminium hydroxide in neutralizing pentagastrin-induced hyperacidity in healthy human volunteers. Almagate (1 g) produced a significantly (p less than 0.01) greater reduction (87.5%) in the titratable acid content of gastric aspirates than did an identical dose of aluminium hydroxide (45.1%). Similarly the pepsin proteolytic activity in the samples of gastric juice was reduced 58.9% by almagate and only 27.5% by aluminium hydroxide. Furthermore the neutralizing effect of almagate was more prolonged (90 min) than that of the standard antacid (30 min) and these first studies in man have therefore confirmed the findings of in vitro and in vivo preclinical experiments.
D000328:Adult; D000536:Aluminum Hydroxide / Q000494:pharmacology*; D000863:Antacids / Q000494:pharmacology*; D002254:Carbonates / Q000494:pharmacology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D006801:Humans; D008274:Magnesium / Q000494:pharmacology*; D008276:Magnesium Hydroxide / Q000494:pharmacology*; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D010434:Pepsin A / Q000494:pharmacology; D013997:Time Factors
D000863:Antacids; D002254:Carbonates; C043698:almagate; D000536:Aluminum Hydroxide; D010434:Pepsin A; D010418:Pentagastrin; D008274:Magnesium; D008276:Magnesium Hydroxide