title: The ins and outs of colicins. Part I: Production, and translocation across membranes.
abstract: Most colicins are plasmid-encoded proteinaceous toxins which act on bacteria closely related to the producing strain (generally Escherichia coli), and which possess the almost unique ability to be translocated across up to four bilayer membranes, two each in the producing and target cells.
mesh_terms: D001693:Biological Transport, Active; D002462:Cell Membrane / Q000378:metabolism; D003087:Colicins / Q000096:biosynthesis* / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D029968:Escherichia coli Proteins; D009154:Mutation; D010957:Plasmids; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic / Q000378:metabolism
chemical_list: D003087:Colicins; D029968:Escherichia coli Proteins; D011956:Receptors, Cell Surface; D011971:Receptors, Immunologic; C028593:colicin receptor, E coli