Action of the benzodiazepine antagonist Ro 15-1788 in humans after sleep withdrawal.
Subsequent to one night of sleep withdrawal the specific benzodiazepine antagonist Ro 15-1788 was infused to 5 healthy volunteers using a double-blind placebo-controlled cross-over design. Using several standardized psychological tests (viso-motor tracking task, complex choice reaction time, trail making test, visual attention and concentration), no performance-improving effects of Ro 15-1788 could be demonstrated. The results are discussed regarding the possible existence of endogenous benzodiazepine ligands.
D000328:Adult; D001143:Arousal / Q000187:drug effects; D001288:Attention / Q000187:drug effects; D001570:Benzodiazepinones / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005442:Flumazenil; D006801:Humans; D008297:Male; D008606:Mental Processes / Q000187:drug effects*; D011597:Psychomotor Performance / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D012892:Sleep Deprivation
D001570:Benzodiazepinones; D005442:Flumazenil