Detection of alpha 1 and alpha 2 heavy-chain constant-region genes in common variable hypogammaglobulinaemia patients with undetectable IgA.
Five patients with common variable hypogammaglobulinaemia with undetectable levels of IgA in serum and saliva were investigated for immunoglobulin structural gene defects. All five patients carried in their genome alpha 1 and alpha 2 genes as detected in Southern blotting analysis by means of a cloned C alpha gene probe.
D000361:Agammaglobulinemia / Q000235:genetics / Q000276:immunology*; D004247:DNA / Q000032:analysis; D005796:Genes; D006801:Humans; D007070:Immunoglobulin A; D007127:Immunoglobulin Constant Regions / Q000235:genetics*; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007137:Immunoglobulin alpha-Chains / Q000235:genetics*; D007136:Immunoglobulins / Q000235:genetics*
D007070:Immunoglobulin A; D007127:Immunoglobulin Constant Regions; D007143:Immunoglobulin Heavy Chains; D007137:Immunoglobulin alpha-Chains; D007136:Immunoglobulins; D004247:DNA