title: Vasoactive drugs and elastic properties of human arteries in vivo, with special reference to the action of nitroglycerine.
abstract: Pulsatile changes in the volume of an arm segment were recorded with an air-filled plethysmograph and related to intra-arterial blood pressure. Alterations in transmural arterial pressure were obtained by changing the pressure in a large chamber surrounding the entire arm. Arterial compliance values were calculated in late diastole when pressure and volume changes were slow. Compliance varied with transmural arterial pressure in a hyperbolic manner, rising steeply at low pressure. Noradrenaline and hypertensin did not change the arterial compliance values, while dihydroergotamine reduced them. Nitroglycerine caused a pronounced increase in compliance values in doses that did not change cardiac output and arterial pressure.
mesh_terms: D000328:Adult; D000802:Angiotensin Amide / Q000494:pharmacology; D001132:Arm / Q000098:blood supply; D001158:Arteries / Q000187:drug effects / Q000502:physiology; D001794:Blood Pressure; D004087:Dihydroergotamine / Q000494:pharmacology; D004548:Elasticity; D006801:Humans; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D009200:Myocardial Contraction; D005996:Nitroglycerin / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D010991:Plethysmography; D014662:Vasoconstrictor Agents / Q000494:pharmacology*
chemical_list: D014662:Vasoconstrictor Agents; D004087:Dihydroergotamine; D000802:Angiotensin Amide; D005996:Nitroglycerin; D009638:Norepinephrine