Marked increase of plasma acid stable/soluble trypsin inhibitor in hemodialysis patients.
The activity of acid stable/soluble trypsin inhibitor (ASTI) was found to be considerably elevated in the plasma of hemodialysis patients (80.3 +/- 24.6 U/ml; 21-fold higher than normal). The increased ASTI was a very acidic compound (pI = 1.66) with a molecular weight (Mr) of 55000 by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE). Immunological identity of the ASTI to urinary trypsin inhibitor was confirmed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002850:Chromatography, Gel; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D005779:Immunodiffusion; D007525:Isoelectric Focusing; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012995:Solubility; D014361:Trypsin Inhibitors / Q000097:blood*
D014361:Trypsin Inhibitors