[Impulse cytophotometry and catamnesis in breast neoplasms].
CEll suspensions from 62 cancers of breast were investigated by flow cytophotometry after staining with pepsin-Ethidium bromide. In all patients a radical operation was made, followed by radiotherapy. The surviving patients were observed for 5 years. From the DNA-histograms 48% of the tumours were classified as diploid (or peridiploid), 40% as polyploid and 11% as aneuploid. Concerning ploidy a rank with worsening prognosis was found from diploid over polyploid to aneuploid cancers. In this sense bad prognosis means: dead or relapse during 5 years, histologically undifferentiated tumours, great primary tumour, metastasis in lymph nodes. In diploid tumours bad prognosis is indicated by a higher part of S- and G2-phase nuclei in the flow histograms. Most of the findings, but not all, are proved statistically. Now as ever, histological differentiation is still the most easily statement for prognosis.
D000782:Aneuploidy; D001943:Breast Neoplasms / Q000032:analysis* / Q000401:mortality / Q000473:pathology / Q000628:therapy; D002453:Cell Cycle; D002467:Cell Nucleus / Q000032:analysis; D003131:Combined Modality Therapy; D004273:DNA, Neoplasm / Q000032:analysis*; D004171:Diploidy; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011123:Polyploidy; D011379:Prognosis
D004273:DNA, Neoplasm
Impulszytophotometrie und Katamnese beim Mammakarzinom.