C1 inhibitor functional activities in hereditary angioedema plasma of patients under therapy with attenuated androgens.
The effects of therapy with danazol or stanozolol on complement component C4 and on C1 inhibitor concentrations and functions in 6 patients suffering from the common form of hereditary angioedema are described. Whereas the mean C4 concentration was found within the normal range, the therapy with attenuated androgens resulted in a subnormal mean of C1 inhibitor concentration, but an almost normal mean of functional activity.
D000799:Angioedema / Q000188:drug therapy / Q000235:genetics / Q000276:immunology*; D003181:Complement C4 / Q000032:analysis; D003613:Danazol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D005779:Immunodiffusion; D008297:Male; D009391:Nephelometry and Turbidimetry; D011245:Pregnadienes / Q000627:therapeutic use*; D013197:Stanozolol / Q000627:therapeutic use*
D003181:Complement C4; D011245:Pregnadienes; D013197:Stanozolol; D003613:Danazol