title: Lithium and tryptophan augmentation in clomipramine-resistant obsessive-compulsive disorder.
abstract: Obsessive-compulsive patients with symptoms resistant to clomipramine were treated by lithium or L-tryptophan augmentation. The improvement noted supports the hypothesis that increasing serotonergic neurotransmission ameliorates obsessive symptoms.
mesh_terms: D000328:Adult; D002986:Clinical Trials as Topic; D002997:Clomipramine / Q000627:therapeutic use*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D016651:Lithium Carbonate; D008297:Male; D009771:Obsessive-Compulsive Disorder / Q000188:drug therapy* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D014364:Tryptophan / Q000627:therapeutic use*
chemical_list: D016651:Lithium Carbonate; D014364:Tryptophan; D008094:Lithium; D002997:Clomipramine