Compared properties of central and peripheral binding sites for phencyclidine.
Phencyclidine and its derivatives bind specifically and reversibly to rat brain and peripheral organs. Binding characteristics are different in brain, lung, kidney, heart and liver. Affinities of phencyclidines for the brain receptor but not those for peripheral organs are correlated with the pharmacological activities of phencyclidines as measured in the rotarod test.
D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000378:metabolism; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009928:Organ Specificity; D010622:Phencyclidine / Q000378:metabolism*; D051381:Rats; D011955:Receptors, Drug / Q000378:metabolism; D017478:Receptors, Phencyclidine
D011955:Receptors, Drug; D017478:Receptors, Phencyclidine; D010622:Phencyclidine