Comparison of the biological and immunological activities of serum luteinizing hormone and follicle stimulating hormone in infertile males.
The biological and immunological activities of luteinizing hormone (LH) and follicle stimulating hormone (FSH) in the serum of infertile males were determined by radioreceptor (RRA) and radioimmunoassay (RIA), respectively. In some sera the biological activity of serum LH was lower than expected on the basis of the RIA-data. In contrast, some sera contained unusually high levels of biologically active LH as demonstrated by RRA, despite not being detected in these amounts by RIA. Prolonged exposure of the gonad to such high levels of biologically active LH might cause end-organ desensitization resulting in infertility. The detection of such cases by the use of RRA could permit therapy in these individuals or exclude patients from treatment.
D000818:Animals; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007248:Infertility, Male / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D011863:Radioimmunoassay / Q000379:methods; D011869:Radioligand Assay / Q000379:methods; D013552:Swine
D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone