The benzodiazepine antagonist, Ro 15-1788, increases REM and slow wave sleep in the dog.
The benzodiazepine antagonist, Ro 15-1788, increases REM and deep slow-wave in dogs at a dose of 10 mg/kg orally. These actions are opposite to that of diazepam. This suggests either that Ro 15-1788 possesses hitherto undescribed intrinsic partial inverse agonist activity or that it is antagonizing an endogenous benzodiazepine-like substance which is involved in modulating sleep-wakefulness.
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D003292:Convulsants / Q000494:pharmacology*; D004285:Dogs; D005442:Flumazenil; D012894:Sleep Stages / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects*; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects
D001570:Benzodiazepinones; D003292:Convulsants; D005442:Flumazenil