Ultrastructural study of intranuclear tubulo-filaments in a giant cell tumour of bone in a patient with Paget's disease.
The intranuclear tubulo-filaments appearing in giant cells were studied ultrastructurally in a giant cell tumour of bone arising in a patient with Paget's disease. Serial sections have shown the presence of invaginating nuclear membrane around these apparent intranuclear tubulo-filaments, thus segregating these structures from the nuclear substance proper. Further sectioning showed clear continuity between these tubulo-filaments and the rest of the cytoplasmic contents. It is found that these apparent intranuclear tubules represent pseudo-inclusions rather than true intranuclear inclusions.
D000368:Aged; D002467:Cell Nucleus / Q000648:ultrastructure*; D003599:Cytoskeleton / Q000648:ultrastructure; D005870:Giant Cell Tumors / Q000648:ultrastructure*; D006801:Humans; D008297:Male; D008441:Maxillary Neoplasms / Q000648:ultrastructure*; D008870:Microtubules / Q000648:ultrastructure; D009364:Neoplasm Recurrence, Local / Q000648:ultrastructure; D009685:Nuclear Envelope / Q000648:ultrastructure; D010001:Osteitis Deformans / Q000150:complications*