[Comparative study of the progestomimetic and contraceptive activity of quingestanol acetate with 5 other progestational molecules].
The progestomimetic, contraceptive activities of quingestanol acetate are compared to those of five molecules (chlormadinone acetate, norgestrel, progesterone, norethisterone acetate, lynestrol). In the opinion of the authors, the therapeutic efficacity of contraceptive pills cannot be judged solely according to the weight of their various ingredients. An appreciation of the value of the various substances is based on a comparison between their physiological activity and their weight. The concept of a mini-dosage pill should therefore be considered, and due consideration paid to the physiological activity of each ingredient. In the experiments described here, quingestanol acetate shows marked statistical differences to the other five molecules.
D000818:Animals; D003276:Contraceptives, Oral; D003280:Contraceptives, Oral, Synthetic; D004305:Dose-Response Relationship, Drug; D005260:Female; D009649:Norpregnadienes / Q000494:pharmacology*; D011374:Progesterone / Q000494:pharmacology; D045167:Progesterone Congeners / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats
D003276:Contraceptives, Oral; D003280:Contraceptives, Oral, Synthetic; D009649:Norpregnadienes; D045167:Progesterone Congeners; D011374:Progesterone
Essai de comparaison de l'activité progestomimétique et contraceptive de l'acétate de quingestanol avec cinq autres molécules progestatives.