[Evaluation of the antianginal action of pharmacological substances by the change in the initiation threshold for myocardial ischemia in conscious rabbits].
The threshold of the initiation of myocardial ischemia was determined for conscious rabbits with the help of a special preliminary implanted appliance, which made it possible to perform the occlusion and reperfusion of the coronary artery. Nitroglycerin and propranolol were shown to increase the threshold of the initiation of ischemia, while dipyridamole was discovered to reduce it. The method described is offered for evaluation of the drug antianginal effect, since it is adequate and easily reproduced.
D000787:Angina Pectoris / Q000188:drug therapy* / Q000209:etiology; D000818:Animals; D003326:Coronary Circulation; D003327:Coronary Disease / Q000188:drug therapy* / Q000209:etiology; D004176:Dipyridamole / Q000627:therapeutic use; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000295:instrumentation / Q000379:methods; D004562:Electrocardiography; D005996:Nitroglycerin / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D011817:Rabbits; D014851:Wakefulness / Q000502:physiology*
D004176:Dipyridamole; D011433:Propranolol; D005996:Nitroglycerin
Otsenka antianginal'nogo deĭstviia farmakologicheskikh veshchestv po izmeneniiu poroga vozniknoveniia ishemii miokarda u bodrstvuiushchikh krolikov.