Hemorrhagic diathesis in multiple myeloma.
Hemorrhage occurs during the clinical course in 15% of patients with multiple myeloma. We recently treated a patient with myeloma who had postoperative bleeding and hematuria despite normal coagulation parameters and platelet count. Platelet function studies revealed markedly abnormal aggregation to all stimulants. Plasma exchange successfully reversed in vitro and in vivo bleeding abnormalities.
D001791:Blood Platelet Disorders / Q000097:blood; D005260:Female; D006474:Hemorrhagic Disorders / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications*; D010951:Plasma Exchange; D010974:Platelet Aggregation