The effects of EDTA in acute cobalt intoxication in rats.
The effect of EDTA on acute cobalt toxicity in rats was the subject of our investigation. There was complete effectiveness for two methods of treatment of the Co and EDTA, except when the CoCl2 was given orally and EDTA intraperitoneally. When the CoCl2-EDTA complex was given orally or intraperitoneally there were no deaths, not even at LD100 values of the CoCl2. No noteworthy changes were brought about in the hematological parameters and serum parameters of the animals receiving the CoCl2-EDTA complexes after a week's treatment. Significant differences appeared in the variation of some blood parameters measured 12 hours after the administration of the Co/CH3-COO)2-EDTA complex compared with the same parameters measured on giving only Co(CH3-COO)2.
D000284:Administration, Oral; D000818:Animals; D003035:Cobalt / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000633:toxicity; D004492:Edetic Acid / Q000494:pharmacology*; D004798:Enzymes / Q000097:blood; D005260:Female; D007274:Injections, Intraperitoneal; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004798:Enzymes; D003035:Cobalt; D004492:Edetic Acid