Inhibition of peptidoglycan synthesis of Streptococcus faecium ATCC 9790 and Streptococcus mutans BHT by the antibacterial agent dodecyl glycerol.
Dodecyl glycerol inhibits the synthesis of the peptidoglycans of Streptococcus faecium ATCC 9790 and Streptococcus mutans BHT. This metabolic regulation represents the second known mode by which dodecyl glycerol expresses antibacterial activity. The first mode of action of dodecyl glycerol was shown to stimulate autolysin activity which degrades cell-wall peptidoglycan (Ved HS, Gustow E, Mahadevan V and Pieringer RA, 1984, J. Biol. Chem. 259, 8115-8121).
D002250:Carbon Radioisotopes; D002701:Chloramphenicol / Q000494:pharmacology; D005989:Glycerides / Q000494:pharmacology*; D007700:Kinetics; D007848:Laurates / Q000494:pharmacology*; D007850:Lauric Acids / Q000494:pharmacology*; D008239:Lysine / Q000378:metabolism; D050178:Monoglycerides; D010457:Peptidoglycan / Q000096:biosynthesis*; D013045:Species Specificity; D013291:Streptococcus / Q000187:drug effects / Q000378:metabolism*; D013295:Streptococcus mutans / Q000187:drug effects / Q000378:metabolism*
D002250:Carbon Radioisotopes; D005989:Glycerides; D007848:Laurates; D007850:Lauric Acids; D050178:Monoglycerides; D010457:Peptidoglycan; C020777:monolaurin; D002701:Chloramphenicol; D008239:Lysine