[Demonstration of the O-demethylation reaction catalyzed by a peroxidase: application to 9-methoxyellipticine].
9-methoxy ellipticine, an antitumor compound, is O-demethylated in presence of the system peroxidase-H2O2; this reaction yields the corresponding electrophilic quinone-imine and methanol. This O-demethylation reaction is reported for the first time and might be possibly extended to some other antitumor drugs.
D000470:Alkaloids / Q000378:metabolism*; D004611:Ellipticines / Q000378:metabolism*; D007700:Kinetics; D010544:Peroxidases / Q000378:metabolism*
D000470:Alkaloids; D004611:Ellipticines; C008009:9-hydroxyellipticine; D010544:Peroxidases; C001729:9-methoxyellipticine
Mise en évidence de la réaction de O-déméthylation catalysée par une peroxydase: application au cas de la méthoxy-9 ellipticine.