Potent antitumor promoting activity of N-6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist, in mouse skin tumor formation induced by 7,12-dimethylbenz[a]anthracene plus teleocidin.
A calmodulin antagonist, N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7) markedly inhibited the promoting activity of teleocidin on formation of skin tumors in mice initiated by 7,12-dimethylbenz[a]anthracene. This result strongly indicates that the critical action of the Ca2+-calmodulin system is responsible for tumor promotion in mouse skin.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity*; D000470:Alkaloids / Q000633:toxicity*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D004336:Drug Antagonism; D005260:Female; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D008235:Lyngbya Toxins; D051379:Mice; D008813:Mice, Inbred ICR; D010743:Phospholipids / Q000096:biosynthesis; D012878:Skin Neoplasms / Q000139:chemically induced*; D013449:Sulfonamides / Q000494:pharmacology*; D014268:Trifluoperazine / Q000494:pharmacology
D000470:Alkaloids; D001551:Benz(a)Anthracenes; D002273:Carcinogens; D008235:Lyngbya Toxins; D010743:Phospholipids; D013449:Sulfonamides; D014268:Trifluoperazine; C022176:teleocidins; D015127:9,10-Dimethyl-1,2-benzanthracene; C017967:W 7