Effects of intermittent haloperidol treatment on dopamine receptor sensitivity in guinea pigs.
Intermittent haloperidol treatment in guinea pigs caused an increase in the behavioral response to apomorphine and an increase in 3H-spiroperidol binding in the striatum to the same degree as continual haloperidol treatment. These results do not support the claim that drug holidays can reduce the incidence of tardive dyskinesia.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003342:Corpus Striatum / Q000187:drug effects; D006168:Guinea Pigs; D006220:Haloperidol / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008297:Male; D011954:Receptors, Dopamine / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
D011954:Receptors, Dopamine; D006220:Haloperidol; D001058:Apomorphine