Study on in vivo decarboxylation of D-penicillamine in rats.
Carboxy-labeled 14C-D-penicillamine was prepared and dosed at 50 mg/kg to Sprague-Dawley rats kept in metabolism cages. The recovery of 14C in excreta, tissue and expired air was 98.4%. The 14CO2 expired amounted only to 1.5% of the 14C-dose indicating that in vivo decarboxylation of the drug in rats is not a significant metabolic pathway.
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D003653:Decarboxylation; D005243:Feces / Q000032:analysis; D008297:Male; D010396:Penicillamine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D002245:Carbon Dioxide; D010396:Penicillamine