Factor VIII inhibitor treatment with high doses of F VIII.
A hemophilic patient with F VIII inhibitor was treated with intermittent F VIII infusions of 40 - 50 units per kg bodyweight per week. Although the inhibitor declined during treatment, an anamnestic response was recorded on two occasions. A continuous high dose F VIII regimen of 200 units per kg per day resulted in reduction of the inhibitor concentration to less than 1 unit per ml. No anamnestic response was seen after a later exposure to intensive F VIII therapy.
D000906:Antibodies / Q000276:immunology*; D002648:Child; D005164:Factor IX / Q000008:administration & dosage; D015949:Factor IXa; D005169:Factor VIII / Q000008:administration & dosage / Q000276:immunology*; D006467:Hemophilia A / Q000276:immunology* / Q000628:therapy; D006801:Humans; D007108:Immune Tolerance; D007156:Immunologic Memory; D008297:Male
D000906:Antibodies; D005169:Factor VIII; D005164:Factor IX; D015949:Factor IXa