Enhancement of T cell MLR reactivity by addition of macrophage supernatants from tumor-bearing mice.
One-way mixed lymphocyte reactions (MLR) were used to establish a correlation between loss of in vitro T cell reactivity and in vivo tumor growth. Though supernatants from anti-Thy 1 treated macrophages (M phi) greatly enhanced MLR activity in normal T cells, such addition had little effect in reversing the inability of T cells from 2-week palpable tumor-bearing mice (TBM) to recognize in vitro foreign histocompatibility antigens. Since normal T cells, exposed to TBM M phi supernatants, exhibited no decrease in proliferative response, TBM T cell loss of MLR reactivity could not be ascribed to tumor-induced suppressor M phi.
D000818:Animals; D005354:Fibrosarcoma / Q000276:immunology*; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D012513:Sarcoma, Experimental / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*