Fat overload syndrome causing respiratory insufficiency.
The fat overload syndrome developed in a 7-year-old girl who was on home TPN which included 20% Intralipid (total lipid dose 3.2 g/kg/d). Acute respiratory insufficiency developed with cough, dyspnea, tachypnea, and cyanosis. The chest x-ray revealed mild cardiomegaly and pulmonary edema. Blood gases showed profound hypoxia (PaO2 29 torr on room air). Spontaneous resolution occurred over the next seven days as the lipemia cleared.
D002648:Child; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D010288:Parenteral Nutrition; D010289:Parenteral Nutrition, Total; D012131:Respiratory Insufficiency / Q000209:etiology*; D013577:Syndrome
D005217:Fat Emulsions, Intravenous; D008055:Lipids