Circulating platelet products in unstable angina pectoris.
In 19 patients with unstable angina pectoris at rest, plasma levels of the platelet-derived proteins beta-thromboglobulin and platelet factor 4 were significantly elevated in blood samples obtained during or within 4 hours after episodes of angina, but were usually normal during quiescent intervals. Plasma levels of the arachidonic acid metabolite thromboxane B2 were less clearly related to angina, and there was no association of angina with levels of the coagulation product fibrinopeptide A. This demonstration of an association of platelet activation and secretion with unstable angina pectoris by radioimmunoassay of circulating platelet constituents offers a new approach to assessment of therapy in ischemic heart disease and suggests that agents that alter platelet function should be evaluated in patients with unstable angina.
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000097:blood* / Q000150:complications / Q000628:therapy; D001792:Blood Platelets; D004562:Electrocardiography; D005260:Female; D005344:Fibrinopeptide A; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000201:enzymology; D010978:Platelet Factor 4; D013923:Thromboembolism / Q000150:complications; D013929:Thromboxane B2; D001620:beta-Thromboglobulin
D001620:beta-Thromboglobulin; D005344:Fibrinopeptide A; D010978:Platelet Factor 4; D013929:Thromboxane B2; D006493:Heparin