[In vivo-acquired resistance to cefsulodin by a strain of Pseudomonas aeruginosa].
We isolated a Pseudomonas aeruginosa strain which was initially cefsulodin-susceptible (J1, MIC = 4 g/l) and became resistant (J2, MIC greater than 64 g/l) after 12 days of treatment of the patient with cefsulodin. Strain J2 had a constitutive beta-lactamase with hydrolytic activities similar to those of a cephalosporinase and an isoelectric point at 8.1. This enzyme (Case) may be related to the ld type. Concomitant development of resistances to various beta-lactams stable to Case suggests that other mechanisms of resistance may be involved.
D002441:Cefsulodin; D002511:Cephalosporins / Q000494:pharmacology* / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D011552:Pseudomonas Infections / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D013997:Time Factors
D002511:Cephalosporins; D002441:Cefsulodin
Résistance acquise in vivo à la cefsulodine par une souche de Pseudomonas aeruginosa.