Stress and epilepsy: the value of a benzodiazepine--lorazepam.
Twenty four patients with drug resistant epilepsy were given lorazepam and placebo added to their pre-existing drug regime. With lorazepam there was a significant reduction in seizures, especially in those with focal and partial complex attacks. The drug proved effective whether or not the patients regarded stress as a trigger to their seizures, but on the Middlesex Hospital Questionnaire there were differences between those with high and low scores.
D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000188:drug therapy*; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy*; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006801:Humans; D008140:Lorazepam / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D013315:Stress, Psychological / Q000150:complications* / Q000188:drug therapy
D000927:Anticonvulsants; D008140:Lorazepam