title: Barrier animal facility operations for a large-scale chronic study (ED01 study).
abstract: The physical facilities of the specific pathogen free/defined flora barrier animal rooms and their support operations are described as used in the conduct of a large-scale, long-term, low-dose carcinogenicity study. Specifically described are the floor plan of the facility, the mechanical operations, air flow, temperature and humidity controls, personnel screening and requirements, cleaning operations, and traffic flow patterns of personnel, equipment, and animals.
mesh_terms: D000818:Animals; D005856:Germ-Free Life; D006799:Housing, Animal; D006813:Humidity; D008029:Lighting; D013047:Specific Pathogen-Free Organisms; D013696:Temperature; D014116:Toxicology / Q000379:methods*; D014691:Ventilation