title: [Continuous alfentanil infusion in surgical interventions of intermediate and long duration].
abstract: Alfentanil, a new short-acting narcotic analgesic, was studied as a continuous infusion for surgical procedures of medium and long duration in 80 patients. Anaesthesia was induced with thiopentone immediately followed by 1 mg of alfentanil to attenuate the stress response to intubation. Alfentanil 100 micrograms/kg was then slowly given as a loading dose before surgery started and anaesthesia maintained by a continuous infusion at a rate of 0.5-1 micrograms/kg/min. Patients were ventilated with a 66% nitrous oxide in oxygen. The course of anaesthesia was good in 76 of the patients, while 27 needed small increments of alfentanil on top of the infusion. Cardiovascular stability was a feature in almost all patients. Recovery was extremely rapid and without complications. Naloxone to reverse respiratory depression was only used twice.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015760:Alfentanil; D000771:Anesthesia, Intravenous; D005260:Female; D005283:Fentanyl / Q000009:adverse effects / Q000031:analogs & derivatives*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D011229:Preanesthetic Medication; D012151:Resuscitation; D013514:Surgical Procedures, Operative; D013997:Time Factors
chemical_list: D015760:Alfentanil; D009270:Naloxone; D005283:Fentanyl
vernacular_title: Alfentanil-Dauerinfusion für chirurgische Eingriffe mittlerer und längerer Dauer.