The importance of the FSH/LH ratio in ovarian stimulation therapy regime for in vitro fertilization.
In a retrospective study batches of hMG with different FSH/LH ratios, as well as pure FSH were used in two different stimulation protocols (Clomiphene/hMG and hMG only). The aim of this paper was to study the effect and importance of the different FSH/LH ratios if any, in ovarian stimulation during the follicular phase on the success of IVF. The results of our preliminary study indicate that as far as ovarian stimulation with Clomiphene/hMG is concerned, there seems to be no significant beneficial effect on IVF success of using pure FSH or gonadotropin preparations with higher FSH/LH ratios. With gonadotropin only for ovarian stimulation however, the use of high FSH/LH ratio seems to significantly increase the pregnancy rate.
D002996:Clomiphene / Q000627:therapeutic use*; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D005498:Follicular Phase / Q000187:drug effects; D006801:Humans; D007986:Luteinizing Hormone / Q000494:pharmacology*; D008596:Menotropins / Q000032:analysis / Q000627:therapeutic use*; D010062:Ovulation Induction / Q000379:methods*; D012189:Retrospective Studies; D013268:Stimulation, Chemical
D002996:Clomiphene; D008596:Menotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone