title: [Suppressor cells and factor of the allogeneic proliferative response in man].
abstract: During multiple in vitro allosensitisations of human lymphocytes, suppressor cells of the allogenic response are developed. They are radioresistant and specific to the HLA-DR presented by the stimulators, and adherent to nylon and glass wool, while cytotoxic cells are not. Moreover when irradiated, these hyperimmunized cells are able to release a suppressor factor (SF). This suppressor factor is non antigen specific and active on the autologous producer and some allogenic responders. There is a restriction phenomenon, the genetic control of which is not yet defined. The dominant effect of multiple transfusions on kidney graft survival could be explained in part by a similar cellular mechanism.
mesh_terms: D002455:Cell Division; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007104:Immune Adherence Reaction; D007114:Immunization; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D050378:T-Lymphocytes, Regulatory / Q000032:analysis / Q000166:cytology* / Q000276:immunology
chemical_list: D006680:HLA Antigens
vernacular_title: Les cellules et facteur suppresseurs de la réponse proliférative allogénique chez l'homme.