Neurotoxic effects of endogenous materials: quinolinic acid, L-pyroglutamic acid, and thyroid releasing hormone (TRH).
The previously reported, dose-related, and selective neurotoxic action of 100 to 200 nmol quinolinic acid on intrastriatal injection was confirmed. A slight neurotoxicity was obtained with 250 nmol thyroid releasing hormone but not with a similar dose of L-pyroglutamic acid.
D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects* / Q000201:enzymology; D005968:Glutamate Decarboxylase / Q000378:metabolism; D007608:Kainic Acid / Q000633:toxicity; D011725:Pyridines / Q000633:toxicity*; D011760:Pyrrolidinones / Q000633:toxicity*; D011761:Pyrrolidonecarboxylic Acid / Q000633:toxicity*; D011805:Quinolinic Acids / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013973:Thyrotropin-Releasing Hormone / Q000633:toxicity*
D011725:Pyridines; D011760:Pyrrolidinones; D011805:Quinolinic Acids; D013973:Thyrotropin-Releasing Hormone; D002795:Choline O-Acetyltransferase; D005968:Glutamate Decarboxylase; D007608:Kainic Acid; D011761:Pyrrolidonecarboxylic Acid