Factor VIII procoagulant antigen recovery is a dose-related response to Factor VIII concentrate infusions.
The recovery and initial half-disappearance rate of factor VIII procoagulant activity (VIIIC) and procoagulant antigen (VIIICAg) were studied in 9 haemophilia A patients following infusion of factor VIII concentrates to varying plasma VIIIC levels. While VIIIC recovery was independent of dose, the VIIICAg recovery varied in a dose-dependent fashion. The excess of VIIICAg relative to VIIIC found in the factor VIII concentrates (VIIICAg/VIIIC ratios of 1.9-3.1) was not observed in plasma samples taken after low level infusions (plasma VIIIC less than 1 U/ml) but a significant excess of VIIICAg was observed in higher level infusions. The VIIICAg recovery of post-infusion plasma was not increased by treatment with phospholipase C.
D000941:Antigens / Q000032:analysis*; D005169:Factor VIII / Q000008:administration & dosage* / Q000032:analysis / Q000276:immunology*; D006467:Hemophilia A / Q000628:therapy; D006801:Humans; D008657:Metabolic Clearance Rate; D013997:Time Factors
D000941:Antigens; D005169:Factor VIII