Specific lysis by 6-hydroxydopamine of catecholaminergic synaptosomes prepared from rat cerebrum.
The toxicity of 6-hydroxydopamine on synaptosomes prepared from rat cerebra was investigated. The drug caused synaptolysis, and the lytic effect was specific to catecholaminergic synaptosomes, since no neurotransmitters (serotonin and amino acids) other than catecholamines (dopamine and noradrenaline) were liberated by the drug.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D006892:Hydroxydopamines / Q000494:pharmacology*; D066298:In Vitro Techniques; D009638:Norepinephrine / Q000378:metabolism*; D016627:Oxidopamine; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects*
D006892:Hydroxydopamines; D016627:Oxidopamine; D004298:Dopamine; D009638:Norepinephrine