title: Stimulation of acid and pepsin secretions in fistulated cats by dimaprit-like compounds.
abstract: In the present paper the Authors describe the effects of dimaprit analogs on cat gastric acid and pepsin secretions. Such compounds are only weakly active as stimulants of H2-receptors, and studied as antagonists fail to inhibit acid and pepsin secretions evoked by dimaprit. The different mechanisms of action of dimaprit and histamine on H2-receptors are discussed.
mesh_terms: D000818:Animals; D002415:Cats; D017259:Dimaprit; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D010434:Pepsin A / Q000378:metabolism*; D011968:Receptors, Histamine / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*; D013268:Stimulation, Chemical; D013270:Stomach / Q000502:physiology; D013890:Thiourea / Q000494:pharmacology*
chemical_list: D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D010434:Pepsin A; D013890:Thiourea; D017259:Dimaprit