[Recovery of the in vitro reactivity of splenic cells of CBA/N mice toward type 2 thymus-independent antigens].
CBA/N mice bearing a chromosome X linked immunological deficiency (Xid) cannot respond to type 2 thymus independent antigens (TI-2). However, when their spleen cells are in vitro simultaneously stimulated by both a TI-2 (Fluorescein conjugated polyacrylamide, Flu-PAA) antigen and a type 1 thymus independent (Trinitrophenyl conjugated Brucella abortus, TNP-BA) antigen, their capacity to respond to the TI-2 antigen is recovered. On the contrary, thymus dependent (TD) Sheep red blood cells (SRBC) antigen did not produce any significant increase of the anti-TI-2 response.
D000818:Animals; D000955:Antigens, T-Independent / Q000276:immunology*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology / Q000276:immunology*
D000955:Antigens, T-Independent
Restauration de la réactivité des cellules spléniques des souris CBA/N in vitro envers des antigènes thymo-indépendants du type 2 (TI-2).