Might the cell damaging effect of alcohol be prevented by redox agents?
It was found that alcohol caused pathological and irreversible decrements of the redox-state potential (redosis) in the pancreas and the liver. On giving reducing agents, a compensatory oxidosis developed, and this could prevent the cell damaging effect of alcohol. This effect was most marked in the reversible phase, while it could be effective also in the irreversible phase. By measuring the redox buffer capacity in the tissues it is possible to determine the measure of reversibility of the injury caused by alcohol.
D000818:Animals; D003545:Cysteine / Q000494:pharmacology; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D010084:Oxidation-Reduction / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats; D013831:Thiamine / Q000494:pharmacology; D008063:Thioctic Acid / Q000494:pharmacology; D014810:Vitamin E / Q000494:pharmacology
D014810:Vitamin E; D000431:Ethanol; D008063:Thioctic Acid; D003545:Cysteine; D013831:Thiamine