Sebaceous gland suppression in female acne patients by combined glucocorticoid-oestrogen therapy.
Women with severe acne were treated with a combination of oestrogen and a low dose of glucocorticoid daily in order to suppress their androgen production. This combination therapy reduced their sebum production by 50%, with a concomitant improvement in their acne.
D000152:Acne Vulgaris / Q000188:drug therapy* / Q000503:physiopathology; D000293:Adolescent; D000328:Adult; D003864:Depression, Chemical; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D004997:Ethinyl Estradiol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009640:Norethindrone / Q000627:therapeutic use*; D011241:Prednisone / Q000627:therapeutic use*; D012627:Sebaceous Glands / Q000187:drug effects / Q000378:metabolism*; D012629:Sebum / Q000378:metabolism; D012636:Secretory Rate / Q000187:drug effects
D004338:Drug Combinations; D004997:Ethinyl Estradiol; D009640:Norethindrone; D011241:Prednisone