[Hypolactatemic effect of sodium difluoroacetate].
In the anesthetized rat, the intraperitoneal injection of 40 mg/kg sodium difluoroacetate (DFA), an activator of the pyruvate dehydrogenase, counteracted the hyperlactatemia induced by a high dose of phenformin (40 mg/kg) injected concomitantly. In the normal conscious dog, the administration of 150 mg/kg by gastric intubation decreased the blood lactate and pyruvate levels; however, this effect was less marked than that produced by the same dose of sodium dichloroacetate (DCA).
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003999:Dichloroacetic Acid / Q000494:pharmacology; D004285:Dogs; D005463:Fluoroacetates / Q000494:pharmacology*; D007773:Lactates / Q000097:blood*; D008297:Male; D010629:Phenformin / Q000494:pharmacology; D011773:Pyruvates / Q000097:blood; D051381:Rats
D001786:Blood Glucose; D005463:Fluoroacetates; D007773:Lactates; D011773:Pyruvates; D003999:Dichloroacetic Acid; D010629:Phenformin; C027495:difluoroacetic acid
Etude de l'effet hypolactatémiant du difluoroacétate de sodium.