[Use of purine derivatives for normalizing the hypothalamic function of rats subjected to gamma-neutron irradiation].
In this work, the authors have made an attempt to correct pharmacologically the disorders in the regulatory function of hypothalamus caused by gamma/neutron-irradiation. For this purpose purine derivatives, ethymisol and meradin, were used. These preparations were effective in correcting fully or partially the postirradiation shifts in the balance between the hypothalamus mediators, catecholamines, and their biosynthetic precursor, dioxyphenylalanine (DOPA). In addition, meradin increased the firmness of the bone regenerator in the traumatized extremity of the animal.
D000225:Adenine / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D004295:Dihydroxyphenylalanine / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D004353:Drug Evaluation, Preclinical; D005042:Etimizol / Q000627:therapeutic use; D005720:Gamma Rays; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D008297:Male; D009502:Neutrons; D009638:Norepinephrine / Q000378:metabolism; D011687:Purines / Q000627:therapeutic use*; D011832:Radiation Injuries / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats
D011687:Purines; D004295:Dihydroxyphenylalanine; C001700:meradine; D000225:Adenine; D005042:Etimizol; D004298:Dopamine; D009638:Norepinephrine
Primenenie proizvodnykh purina dlia normalizatsii funktsii gipotalamusa krys, podvergnutykh gamma-neĭtronnomu oblucheniiu.