title: Human pharmacologic trials with iohexol.
abstract: Injections of iohexol in two series of volunteers, 20 in 1980 and 16 in 1982 are briefly reported. Intravenous injections of iohexol in doses from 125 to 1500 mg I/kg body weight were well tolerated. Iohexol was completely excreted in unchanged form. The results indicate that iohexol may safely be used in clinical trials.
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002860:Chromium Radioisotopes; D003287:Contrast Media / Q000378:metabolism / Q000633:toxicity*; D004341:Drug Evaluation; D004492:Edetic Acid; D004562:Electrocardiography; D006207:Half-Life; D006261:Headache / Q000139:chemically induced; D006801:Humans; D007463:Iodobenzoates / Q000633:toxicity*; D007472:Iohexol; D007668:Kidney / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects; D013961:Thyroid Gland / Q000187:drug effects; D014018:Tissue Distribution; D014283:Triiodobenzoic Acids / Q000378:metabolism / Q000633:toxicity*
chemical_list: D002860:Chromium Radioisotopes; D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D007472:Iohexol; D004492:Edetic Acid