Rapid gas chromatographic assay for monitoring valproic acid and valpromide in plasma.
A gas chromatographic (GC) method for monitoring valproic acid and valpromide in plasma was developed. The procedure involved a single solvent extraction of drugs from acidified plasma samples, followed by a GC injection of the organic phase. This rapid, sensitive, specific, and reproducible method is a key factor in pharmacokinetic and stability studies of valpromide. Pharmacokinetic application of the new GC method is presented by a simultaneous plasma monitoring of valpromide and valproic acid levels obtained after intravenous administration of valpromide to a dog.
D002849:Chromatography, Gas / Q000379:methods; D004355:Drug Stability; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated / Q000097:blood*; D006801:Humans; D007700:Kinetics; D014635:Valproic Acid / Q000097:blood*
D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; C014168:2-propyl-2-pentenoic acid; D014635:Valproic Acid