Disposition and metabolism of diphenyl ether in rats.
After i.p. administration of [14C]diphenyl ether (5 mg/kg) to rats, radioactivity was detected rapidly in all organs and tissues. After intragastric administration of [14C]diphenyl ether (10 mg/kg) to rats, unchanged diphenyl ether in the blood was at max. concn. within 15 h and decreased linearly with time, with a biological half-life of about 1.5 h. More than 90% of the intragastrically administered dose was excreted in urine and faeces within three days; greater than 80% dose was in the urine. From g.l.c. and mass-spectral data, it was shown that rats metabolized diphenyl ether to its 2-hydroxy, 4-hydroxy, 4,4'-dihydroxy, 4-methoxy-monohydroxy and 4-methoxy-dihydroxy derivatives.
D000818:Animals; D001711:Biotransformation; D002849:Chromatography, Gas; D004750:Enteral Nutrition; D008658:Inactivation, Metabolic; D007274:Injections, Intraperitoneal; D008297:Male; D010647:Phenyl Ethers / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D010647:Phenyl Ethers; C031538:phenyl ether