title: [Testing of the steroid-related suppressive effect on the hypothalamo-hypophyseal system using twofold stimulation].
abstract: Intravenous administration of gonadotropin-releasing hormone (GnRH) induces not only a rapid release of pituitary LH and FSH stored, but also stimulates biosynthesis of these hormones by a long acting process. Repeated injection of GnRH after an interval of 90 to 120 minutes evokes an increased response compared with the first period of stimulation. This pattern of reaction is principally maintained on therapy with steroidal contraceptives. The twofold stimulation provides additional information on hypothalamic-pituitary reactivity exceeding the results yielded by the simple GnRH stimulation test. On the contrary examination of prolactin response to twofold TRH-administration gives no increased diagnostic aid.
mesh_terms: D003277:Contraceptives, Oral, Combined / Q000494:pharmacology; D004338:Drug Combinations; D004997:Ethinyl Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D007986:Luteinizing Hormone / Q000097:blood; D008598:Menstruation / Q000187:drug effects; D009640:Norethindrone / Q000494:pharmacology*; D009644:Norgestrel / Q000494:pharmacology*; D010906:Pituitary Hormone-Releasing Hormones / Q000008:administration & dosage / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D003277:Contraceptives, Oral, Combined; D004338:Drug Combinations; D010906:Pituitary Hormone-Releasing Hormones; C025723:ethinyl estradiol sulfonate; D009644:Norgestrel; D004997:Ethinyl Estradiol; C011436:Deposiston; D013973:Thyrotropin-Releasing Hormone; D019304:Ethinyl Estradiol-Norgestrel Combination; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D009640:Norethindrone
vernacular_title: Zur Testung steroidbedingter Suppressionseffekte auf das Hypothalamus-Hypophysen-System mit Hilfe der Doppelstimulierung.