Influence of thymic humoral factor(s) on haemopoiesis in mice.
Postirradiation administration of Leukotrophin to whole-body irradiated mice was associated with increased LD50/30 and DRF. As indicated by 59Fe uptake and ESC number, haemopoiesis was significantly stimulated in spleen and bone marrow after Leukotrophin application to irradiated mice. DNA content and the uptake of 3H-thymidine in DNA was significantly enhanced in the thymus and bone marrow of irradiated and Leukotrophin-treated mice. The micronucleus test confirmed that Leukotrophin is a therapeutic agents, while administered before irradiation it does not influence the initial radio-lesions.
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects; D006410:Hematopoiesis / Q000187:drug effects*; D051379:Mice; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects; D013949:Thymus Extracts / Q000494:pharmacology*
D013949:Thymus Extracts; C024817:leukotrophin