[FT-207 and 5-FU concentrations in brain tumor tissues, plasma and CSF after administration of FT-207 suppository].
FT-207 suppository was administered to 19 patients with brain tumors. FT-207 and 5-FU concentrations in tumor tissues and plasma were measured using chemical assay method. After operation, FT-207 and 5-FU concentrations in plasma and CSF were measured serially for 24 hours in some patients following administration of FT-207 suppository. Following results were obtained. 1) The level of 5-FU concentration in tumor tissues was higher than that of in plasma while the level of FT-207 concentration in tumor tissues was lower than that of in plasma. 2) The level of 5-FU concentration in CSF had been kept highly very longer time, compared with that of in plasma. On the other hand the level of FT-207 concentration in plasma and CSF decreased rapidly. 3) About 0,05 mcg/ml of 5-FU in CSF would be maintained for 24 hours in patients following administration of FT-207 suppository (1 g, daily) for 3 days or more.
D001921:Brain / Q000378:metabolism*; D001932:Brain Neoplasms / Q000134:cerebrospinal fluid / Q000188:drug therapy* / Q000378:metabolism; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D006801:Humans; D012007:Rectum; D013488:Suppositories; D005641:Tegafur / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*
D013488:Suppositories; D005641:Tegafur; D005472:Fluorouracil