title: Individual-specific (idiotypic) T-B cell interactions regulating the production of anti-2,4,6-trinitrophenyl antibody. II. Development of idiotype-specific helper and suppressor T cells within mice making an immune response.
abstract: The previous report demonstrated that serum and cells from CBA mice immunized with trinitrophenyl (TNP), when injected into normal, syngeneic "recipient" mice, induce the formation of apparently idiotype-specific suppressor cells and serum factors, and that such regulatory elements develop within the serum of the TNP-immunized animals themselves. In this report, it is indicated that regulator cells develop also within the spleens of TNP-keyhole limpet hemocyanin-immunized animals, and may in part be responsible for our earlier observation that T cells from TNP-immune CBA mice stimulate optimal antibody production in culture when paired with B cells from the same individual animal. While some evidence for individual-specific T helper cells was obtained, the poorer response of mismatched T and B cells could be attributed in part to Ly-2.2-bearing suppressor T cells. Overall, the results support the view that idiotype-related regulation is not confined to dominant-idiotype models but is also involved in heterogeneous anti-hapten antibody responses.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D006433:Hemocyanins / Q000276:immunology; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D008211:Lymphocyte Cooperation; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory; D014301:Trinitrobenzenes / Q000276:immunology
chemical_list: D007130:Immunoglobulin Idiotypes; D014301:Trinitrobenzenes; D006433:Hemocyanins