The effects of brotizolam, a new hypnotic, on cardiac and respiratory function in volunteers.
In a double-blind, cross-over study we measured the effect of a 0.5-mg oral dose of brotizolam, a new thienodiazepine hypnotic, on cardiac and respiratory functions in 12 healthy volunteers. No deleterious effects on pulse, blood pressure, forced vital capacity, forced expiratory volume in 1 s, respiratory rate, mouth occlusion pressure (P0.1) and ventilatory responses to carbon dioxide occurred over a 6-hour period. In the usual therapeutic dose, brotizolam does not suppress cardiac and respiratory functions in healthy volunteers.
D000328:Adult; D001381:Azepines / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002245:Carbon Dioxide / Q000502:physiology; D002628:Chemoreceptor Cells / Q000187:drug effects; D005541:Forced Expiratory Volume; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D012119:Respiration / Q000187:drug effects*; D012125:Respiratory Center / Q000187:drug effects; D014797:Vital Capacity
D001381:Azepines; D006993:Hypnotics and Sedatives; D002245:Carbon Dioxide; C020960:brotizolam