[Mitogenic responses of splenic lymphoid cells of rats exposed in vitro to normobaric oxygen].
Rat spleen cells were cultivated in 1 ATA pure oxygen. The mitogenic responses with Con A were evaluated at different time of exposure (12 to 72 hrs). There was a stimulation of the cells after 12 hrs of exposure, which diminished at 18 hrs, in spite of the fact that the viability of the cells remained unchanged till 24 hrs of exposure. The kinetics of the mitogenic response of the splenic lymphocytes exposed to oxygen is biphasic as has been observed after irradiation.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects; D010100:Oxygen / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000166:cytology* / Q000187:drug effects
D010100:Oxygen
Réponses mitogéniques des cellules lymphoïdes spléniques de Rat exposées in vitro à l'oxygène normobare.