Effects of 6-hydroxydopamine on the carbohydrate metabolism of skeletal and heart muscles in rest and during exercise.
A mild 10 min exercise, induced by "in vivo" electrical stimulation of the rat gastrocnemius, causes decreases of the muscle glycogen content (G) and phosphorylase alpha activity (PA), and an increase of its overall glycolytic capacity (OGC); in the myocardium, PA decrease of liver glycogen were brought about by peripheral administration of 6-OHDA; these were probably also related to tissue hypoxia. Modifications elicited by exercise in 6-OHDA treated rats (increase of PA, but no modification of G and OGC in GM; decrease of G in the liver; decrease of OGC in M) suggest some impairments of the ability to adapt the tissue metabolism to increased energetic needs.
D000818:Animals; D050260:Carbohydrate Metabolism; D006321:Heart / Q000187:drug effects*; D006892:Hydroxydopamines / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D016627:Oxidopamine; D005082:Physical Exertion / Q000187:drug effects*; D051381:Rats; D012146:Rest; D013563:Sympathectomy, Chemical; D013997:Time Factors
D006892:Hydroxydopamines; D016627:Oxidopamine