Serotoninergic modulation of mesolimbic and frontal cortical dopamine neurons.
Potentiation of the effect of haloperidol on dopamine metabolism by the 5-HT uptake inhibitor CGP 6085 A, and antagonism of this effect by the 5-HT antagonist mianserin were observed in the mesolimbic area and the frontal cortex of the rat brain. A similar effect was reported earlier in the corpus striatum. This suggests that serotoninergic modulation of dopamine neurons is a generally-occurring phenomenon in the brain.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D001572:Benzofurans / Q000494:pharmacology; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D010134:Fenclonine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology*; D006719:Homovanillic Acid / Q000378:metabolism; D008032:Limbic System / Q000378:metabolism*; D008803:Mianserin / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009928:Organ Specificity; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*
D001572:Benzofurans; D010880:Piperidines; D015102:3,4-Dihydroxyphenylacetic Acid; D008803:Mianserin; D012701:Serotonin; C015613:4-(5,6-dimethyl-2-benzofuranyl)piperidine; D006220:Haloperidol; D010134:Fenclonine; D004298:Dopamine; D006719:Homovanillic Acid