Influence of STS 557 on the mitotic activity in the endometrium of ovariectomized mice and comparison with the effects of progesterone and levonorgestrel.
The numbers of mitoses in the epithelial and stromal tissues of mouse uteri were recorded after treatment with various doses of progesterone (P), levonorgestrel (LN), and STS 557 (17 alpha-cyanomethyl-17 beta-hydroxy-estra-4,9(10)-diene-3-one). All three progestins induced mitotic activity in the stromal tissue of the endometrium in which P and LN were much more active than STS 557. While the cell divisions in the luminal and glandular epithelium induced by P were only rare, LN and STS 557 enhanced the mitosis rates in these tissues significantly at a daily dose of 1.0 mg/animal on 5 consecutive days. The results are discussed with special regard to the post-coital antifertility effect of STS 557.
D000818:Animals; D002369:Castration; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology; D004717:Endometrium / Q000166:cytology / Q000187:drug effects*; D005260:Female; D016912:Levonorgestrel; D051379:Mice; D008938:Mitosis / Q000187:drug effects*; D009277:Nandrolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D009644:Norgestrel / Q000494:pharmacology*; D011374:Progesterone / Q000494:pharmacology*
D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D009644:Norgestrel; C023635:dienogest; D011374:Progesterone; D016912:Levonorgestrel; D009277:Nandrolone