Normal survival of Rh0 (D) negative, LW (a+) red cells in a patient with allo-anti LWa.
The serum of an Rh0 (D)+ Caucasian female with a prior history of transfusions contained anti- LWa , reacting moderately with Rh0 (D)+ and weakly with Rh0 (D)- red cells at the antiglobulin phase. Since transfusions were required, Chromium (51Cr) survival studies and mononuclear phagocyte assays (MPA) were used to predict in vivo survival. The MPA value of 6% of the positive control predicted a low likelihood of clinically significant extravascular destruction and 51Cr survival studies indicated greater than 95% survival at 1 h and 78% survival at 20 h for rr erythrocytes. Transfusion of 4 units of Rh0 (D)-, serologically incompatible red cells increased the hemoglobin from 5.2 to 11.4 g/dl and the titer of anti- LWa against rr red cells from 4 to 1,024 7 days after the transfusion. A second 51Cr survival also indicated normal survival of rr erythrocytes. 3 additional Rh0 (D)- units were successfully transfused.
D000368:Aged; D001789:Blood Group Antigens / Q000276:immunology*; D001788:Blood Grouping and Crossmatching; D001803:Blood Transfusion; D002470:Cell Survival; D017707:Erythrocyte Transfusion; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System
D001789:Blood Group Antigens; D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System