Noxythiolin--high-performance liquid chromatographic assay and stability.
A rapid stability-indicating high-performance liquid chromatographic assay for noxythiolin has been developed and its application to the determination of the shelf-life of solid and solution forms is illustrated. Kinetic models which describe the degradation profile have been evaluated and concentrated solutions are modelled by a A B + C system whereas more dilute solutions approximate to the A B or limiting first-order case.
D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008956:Models, Chemical; D009677:Noxythiolin / Q000032:analysis*; D013696:Temperature; D013890:Thiourea / Q000031:analogs & derivatives*
D009677:Noxythiolin; D013890:Thiourea