Immunization with Pseudomonas aeruginosa high-molecular-weight polysaccharides prevents death from Pseudomonas burn infections in mice.
High-molecular-weight polysaccharides from the extracellular slime of Pseudomonas aeruginosa were evaluated as immunogens in Pseudomonas burn infections in mice. Immunization with immunotype 1 or 2 polysaccharides induced a strong immunotype-specific and weak cross-reactive antibody response but protected mice against burn infections caused by either immunotype. Passive protection was provided by rabbit antiserum to immunotype 1 polysaccharide against burn infection by the homologous organism. Pseudomonas high-molecular-weight polysaccharides are potentially effective vaccines in burn infections.
D000818:Animals; D000917:Antibody Formation; D002056:Burns / Q000150:complications*; D003429:Cross Reactions; D005260:Female; D051379:Mice; D008809:Mice, Inbred C3H; D008970:Molecular Weight; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D011552:Pseudomonas Infections / Q000150:complications / Q000401:mortality*; D011550:Pseudomonas aeruginosa / Q000276:immunology*
D011135:Polysaccharides, Bacterial