IgA polymorphism in mice: individual light chains can pair covalently with some alpha heavy chains and non-covalently with others.
The molecular basis for the two different forms of IgA in mice, distinguished by the covalent or non-covalent association of light (L) and heavy (H) chains, is unknown. In this communication, we show, using somatic cell hybridization to construct cells producing new combinations of alpha and L chains, that individual L chains probably can pair both covalently and non-covalently depending on the alpha chain.
D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D006822:Hybrid Cells / Q000276:immunology; D007070:Immunoglobulin A / Q000096:biosynthesis; D007147:Immunoglobulin Light Chains / Q000096:biosynthesis; D007137:Immunoglobulin alpha-Chains / Q000096:biosynthesis; D051379:Mice
D007070:Immunoglobulin A; D007147:Immunoglobulin Light Chains; D007137:Immunoglobulin alpha-Chains