[Possibilities for optimizing therapy with theophylline preparations. Clinical effectiveness and side effects of microcrystalline theophylline].
The efficacy of microcrystalline theophylline is examined in patients with stabilized bronchial asthma. Beside the concentration of theophylline in the serum are estimated: the changes of subjective state of health, the consumption of beta2-stimulants, VC and FEV1. Although in 8 of 10 patients the theophylline concentration in the serum was below the therapeutical range for a considerable period of time, an improvement of the subjectively estimated state of health, a diminished consumption of beta2-stimulants and an increasing VC and FEV1 are evident after 6-7 days, also statistically confirmed. Proposals are suggested for using all possibilities for an improved therapy with theophylline.
D000328:Adult; D001249:Asthma / Q000188:drug therapy; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007700:Kinetics; D008134:Long-Term Care; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D008297:Male; D013806:Theophylline / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use*; D014797:Vital Capacity / Q000187:drug effects
D013806:Theophylline
Optimierungsmöglichkeiten bei der Therapie mit Theophyllinpräparaten. II. Klinische Wirksamkeit und Nebenwirkungen von mikrokristallinem Theophyllin.