title: Polymerization of human transcortin in plasma.
abstract: Using radial immunodiffusion and antiserum raised against purified transcortin, polymers of native transcortin have been identified in plasma. They are characterized by multiple precipitin bands, the size of which diminishes on dilution, consistent with reversibility of this form of polymer. Spectrophotometric scans have been used to study the time course of polymerization in purified transcortin, in which dilution reversibility can be demonstrated also, and in which disaggregation may be produced by addition of sodium dodecyl sulphate and dithiothreitol, but apparently not by cortisol.
mesh_terms: D006801:Humans; D007106:Immune Sera; D005779:Immunodiffusion; D007700:Kinetics; D046911:Macromolecular Substances; D013056:Spectrophotometry, Ultraviolet; D014156:Transcortin / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D007106:Immune Sera; D046911:Macromolecular Substances; D014156:Transcortin