Effect of steroid hormones on arachidonic acid metabolites of endothelial cells.
The effect of estrogen, progesterone, testosterone, and hydrocortisone on prostacyclin, thromboxane, prostaglandin E, and prostaglandin F from cultured endothelial cells was investigated. No effect was found on prostacyclin, prostaglandin E, and prostaglandin F. Estrogen increased the release of thromboxane. The significance of this finding with regard to venous thrombolic events associated with estrogen use is discussed.
D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D002478:Cells, Cultured; D004727:Endothelium / Q000166:cytology; D011464:Epoprostenol / Q000096:biosynthesis; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D011458:Prostaglandins E / Q000096:biosynthesis; D011460:Prostaglandins F / Q000096:biosynthesis; D013739:Testosterone / Q000494:pharmacology*; D013931:Thromboxanes / Q000096:biosynthesis
D001095:Arachidonic Acids; D011458:Prostaglandins E; D011460:Prostaglandins F; D013931:Thromboxanes; D016718:Arachidonic Acid; D013739:Testosterone; D004997:Ethinyl Estradiol; D011374:Progesterone; D011464:Epoprostenol; D006854:Hydrocortisone