Suppression of feeding by naloxone in rat: a dose-response comparison of anorexia and conditioned taste aversion suggesting a specific anorexic effect.
The dose-related suppression of feeding by naloxone (0.25-15.0 mg/kg), either by injection before feeding, or by conditioning taste aversion (CTA), was compared. The weaker suppression found for CTA at low (below 0.75 mg/kg) and high (above 5.0 mg/kg) doses suggests that the aversive sequelae of naloxone injection cannot account fully for its suppressive effects. In turn, this suggests that naloxone exerts a specific anorexic effect. Comprehensive dose-response curves for naloxone anorexia (15 doses) and CTA (nine doses) are presented.
D000704:Analysis of Variance; D000818:Animals; D003213:Conditioning, Psychological / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste
D009270:Naloxone