title: Primary tumor growth and formation of spontaneous lung metastases in mice bearing Lewis carcinoma treated with proteinase inhibitors.
abstract: The differential effects on primary tumor growth and on the formation of spontaneous pulmonary metastases have been determined for a series of proteinase inhibitors. The substances included the gold compounds, aurothioglucose and aurothiomalate, D(-)penicillamine, phosphoramidon and an egg-white inhibitor of cysteine proteinase (EWI). The i.p. administration of these substances to mice bearing s.c. Lewis lung carcinoma cause varying degrees of antineoplastic effects; the most pronounced effects on metastases are caused by phosphoramidon. The inactivity of EWI on tumor progression is concomitant with an inhibition to 50% of cathepsin B in tumor homogenates. The selective antimetastatic action of phosphoramidon is in agreement with the crucial role proposed for tumor collagenases in tumor dissemination.
mesh_terms: D000818:Animals; D006051:Aurothioglucose / Q000627:therapeutic use; D003546:Cysteine Endopeptidases; D010450:Endopeptidases / Q000627:therapeutic use; D005260:Female; D006020:Glycopeptides / Q000627:therapeutic use; D006052:Gold Sodium Thiomalate / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000188:drug therapy / Q000201:enzymology / Q000556:secondary*; D051379:Mice; D010396:Penicillamine / Q000627:therapeutic use; D011480:Protease Inhibitors / Q000627:therapeutic use*
chemical_list: D006020:Glycopeptides; D011480:Protease Inhibitors; D006052:Gold Sodium Thiomalate; D006051:Aurothioglucose; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; D010396:Penicillamine; C008890:phosphoramidon