Left ventricular mechanics in dilated cardiomyopathy.
The influence of altered chamber shape on the evaluation of left ventricular (LV) mechanics in idiopathic dilated cardiomyopathy (IDC) is unknown. Nine patients with IDC and 7 subjects with normal LV function were studied with simultaneous LV pressure and M-mode echographic recordings in order to derive LV meridional wall stress. The major axis of the left ventricle, determined from the left ventriculogram at rest, allowed for derivation of circumferential wall stress. The IDC group was characterized by larger end-diastolic and end-systolic LV volumes, increased LV mass, depressed angiographic ejection fraction and more spherical LV chamber shape. Both end-systolic meridional (114 +/- 30 kdyne/cm2) and circumferential (251 +/- 73 kdyne/cm2) wall stresses were elevated in patients with IDC, although the ratio of these stresses was less than normal (2.2 +/- 0.1 vs 2.7 +/- 0.2, respectively). LV load alteration with phenylephrine or nitroglycerin allowed for construction of end-systolic stress-minor-axis dimension and end-systolic stress-minor-axis shortening relations. Similar mean slopes of the meridional end-systolic stress-dimension relation were noted in IDC and normal subjects, although the line was displaced to the right in IDC. The slope of the circumferential end-systolic stress-dimension relation was, however, decreased in patients with IDC. Moreover, the end-systolic stress-fractional minor-axis shortening relation in patients with IDC was displaced downward from the normal relation supporting depressed contractile function in these IDC patients.(ABSTRACT TRUNCATED AT 250 WORDS)
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002311:Cardiomyopathy, Dilated / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006333:Heart Failure / Q000503:physiopathology*; D006352:Heart Ventricles / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D005996:Nitroglycerin / Q000627:therapeutic use; D010656:Phenylephrine / Q000627:therapeutic use; D013318:Stroke Volume / Q000187:drug effects
D010656:Phenylephrine; D005996:Nitroglycerin