Electrical stimulation of experimental nonunions.
Hypertrophic and oligotrophic nonunions were prepared by resection of a portion of the proximal ulna in dogs. In the hypertrophic nonunions, 20 muamps of direct current for eight weeks produced an increase in bone formation compared to the opposite control limb by radiography, photometry, point counting of new bone, and growth rate by sequential fluorochrome labeling and the dynamic uptake of 99mTc-labeled methylene disphosphonate. Oligotrophic nonunions were treated by plating and aspiration grafting in addition to direct-current stimulation. Ony the point counting of new bone showed a significant increase in bone formation with stimulation. Sequential fluorochrome labeling demonstrated that the new bone was laid down on existing bone and not primarily adjacent to the cathode within the fibrous nonunion. This finding supports the cell-mediated rather than physicochemical effect of electrostimulation.
D000818:Animals; D004164:Diphosphonates / Q000378:metabolism; D004285:Dogs; D004599:Electric Stimulation Therapy; D005599:Fractures, Ununited / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D008852:Microradiography; D010012:Osteogenesis; D010783:Photometry; D011336:Probability; D013667:Technetium / Q000378:metabolism; D013669:Technetium Tc 99m Medronate; D013997:Time Factors; D014458:Ulna Fractures / Q000628:therapy
D004164:Diphosphonates; D013667:Technetium; D013669:Technetium Tc 99m Medronate