A mechanism of enhancement of immune complex deposition following in situ immune complex formation in the mouse glomerulus.
The intravenous injection into mice of small amounts of heat-aggregated bovine serum albumin (BSA) results in deposition of BSA within the glomerulus. Injection of rabbit anti-BSA antibody at a time when all circulating BSA has been cleared results in in situ formation of BSA anti-BSA immune complexes with fixation of mouse C3. Subsequent injection of passively-prepared immune complexes gives much enhanced deposition of immune material when compared with mice given immune complexes alone. This paper shows that this is an antigen-specific phenomenon and not a result of non-specific trapping by damaged glomeruli. The implications of these observations on the pathogenesis of immune complex glomerulonephritis are discussed.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology*; D000941:Antigens / Q000276:immunology; D005921:Glomerulonephritis / Q000209:etiology; D007105:Immune Complex Diseases / Q000209:etiology / Q000276:immunology; D007678:Kidney Glomerulus / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D012710:Serum Albumin, Bovine / Q000276:immunology
D000936:Antigen-Antibody Complex; D000941:Antigens; D012710:Serum Albumin, Bovine