[Adaptation of the myocardium to ischemia: study of suspension of the mitochondria as related to the development of the collateral circulation].
The authors developed an experimental model by means of which they established in the dog the role of short duration ischaemia (1-5 minutes) in triggering local haemodynamic changes that led to the rapid development of a collateral circulation, with retrograde filling, able to furnish subsequently blood supply to the distal segment of a main coronary artery obstructed for 20 minutes. Histological study, electron microscopy, biochemical tests and mitochondrial suspensions revealed the value of the latter method, being the most reliable test for appraising the remaining postischaemic functional potential. The data obtained may serve as a basis for understanding the role of the coronary colateral circulation in man, in coronary obstruction, and the means of developing this circulation.
D000818:Animals; D003097:Collateral Circulation; D003326:Coronary Circulation; D003327:Coronary Disease / Q000503:physiopathology*; D003331:Coronary Vessels / Q000473:pathology; D004285:Dogs; D006801:Humans; D008929:Mitochondria, Heart / Q000648:ultrastructure*; D009206:Myocardium / Q000648:ultrastructure
Adaptarea miocardului la ischemie: studiul suspensiei de mitocondrii în relaţie  cu dezvoltarea circulatiei colaterale coronariene.