Contact sensitivity to quinidine sulfate from occupational exposure.
Three workers exposed to quinidine sulfate became sensitized after short exposure times (2-3 months). They were patch test positive to quinidine in different vehicles, but negative to the diastereoisomer quinine. Guinea pig maximization tests demonstrated quinidine and quinine to be grade V allergens according to the classification of Magnusson & Kligman. When challenged for cross reactivity, the animals sensitive to quinine did not react to quinidine. Among the quinidine-sensitive guinea pigs, three of 20 (P greater than 0.05) reacted when challenged with quinine.
D000328:Adult; D000818:Animals; D003429:Cross Reactions; D003877:Dermatitis, Contact / Q000209:etiology*; D009783:Dermatitis, Occupational / Q000209:etiology*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D011802:Quinidine / Q000009:adverse effects*; D011803:Quinine / Q000009:adverse effects
D011803:Quinine; D011802:Quinidine