Inhibition of protein A-induced lymphocyte colony-forming cells by con A-generated suppressor cells or their culture fluid.
Concanavalin A (Con-A)-treated human lymphocytes or their culture fluid suppressed protein A-induced lymphocyte colony formation by more than 40%. The suppressor factor was produced primarily by Con A-stimulated T lymphocytes and maximal production occurred on the 2nd day of culture with 10 microgram Con A, a condition optimal for the induction of suppressor T cells. This suggests that the factors are released by suppressor T cells. We hypothesize that suppressor T cells exert a negative control on clonal proliferation of lymphocytes.
D001402:B-Lymphocytes / Q000378:metabolism; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000166:cytology* / Q000276:immunology; D008222:Lymphokines / Q000494:pharmacology; D008937:Mitomycins / Q000494:pharmacology; D010835:Phytohemagglutinins / Q000494:pharmacology; D013205:Staphylococcal Protein A / Q000494:pharmacology*; D013491:Suppressor Factors, Immunologic; D013601:T-Lymphocytes / Q000378:metabolism; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D008070:Lipopolysaccharides; D008222:Lymphokines; D008937:Mitomycins; D010835:Phytohemagglutinins; D013205:Staphylococcal Protein A; D013491:Suppressor Factors, Immunologic; D003208:Concanavalin A