[Mechanisms of hemopoiesis inhibition and recovery after the administration of carminomycin and rubomycin in an experiment].
The experiments on 766 albino non-inbred rats and 270 mice BALB/c showed that when there were no basic differences in the mechanism of the anthracycline myeloinhibitory effect associated with a decrease in the number of the exogenic trunk hemopoietic cells, inhibition of the bone marrow proliferative activity and a decreased rate of the hemopoietic elements differentiation, carminomycin induced a more pronounced and persisting impairment of the hematopoietic tissue proliferation, as compared to rubomycin on their administration in doses equivalent by the total toxicity.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002360:Carubicin / Q000633:toxicity*; D002869:Chromosome Aberrations; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000633:toxicity*; D003864:Depression, Chemical; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008938:Mitosis / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D002360:Carubicin; D003630:Daunorubicin
Mekhanizmy podavleniia i reparatsii gemopoéza pri vvedenii karminomitsina i rubomitsina v éksperimente.