Hydrazonopropionic acids, a new class of hypoglycemic substances, 3. Inhibition of jejunal glucose uptake in the rat and guinea pig.
Recently hydrazonopropionate derivatives have been recognized as a new group of compounds with strong hypoglycemic effects in various laboratory animals. The hypoglycemia probably has several causes of which an inhibition of gluconeogenesis and of intestinal glucose uptake could be identified. In the present report, the influence of phenylethylhydrazonopropionate, cyclohexylethylhydrazonopropionate, methylcinnamylhydrazonopropionate and their corresponding hydrazine derivatives on the glucose uptake of rat and guinea pig jejunum has been compared with the well known effects caused by phenformin. All substances tested inhibited the jejunal glucose uptake, phenelzine, methylcinnamylhydrazine and cyclohexylhydrazonopropionate more effective, the other compounds less effective than phenformin. The hydrazine derivatives appeared more effective than the hydrazone compounds used. The cellular ATP/ADP ratio was not influenced by the hydrazonopropionate compounds.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002934:Cinnamates / Q000494:pharmacology; D004355:Drug Stability; D005947:Glucose / Q000378:metabolism*; D006168:Guinea Pigs; D006835:Hydrazones / Q000494:pharmacology; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000378:metabolism; D007773:Lactates / Q000096:biosynthesis; D019344:Lactic Acid; D010477:Perfusion; D011422:Propionates / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D002934:Cinnamates; D006835:Hydrazones; D007004:Hypoglycemic Agents; D007773:Lactates; D011422:Propionates; D019344:Lactic Acid; D000244:Adenosine Diphosphate; C039804:BM 42304; D000255:Adenosine Triphosphate; D005947:Glucose