[Ionic mechanisms of the electrical activity of the smooth-muscle cells of the lymphatic vessels].
APs of smooth muscles of isolated lymphatic vessels were recorded by means of the single sucrose-gap method. Plateau APs with sharp spikes on the plateau were recorded in Krebs' solution. Low-sodium solutions led to discontinuation of the plateau phase whereas calcium-free solution eliminated the sharp spikes. Increase of the intravascular pressure during the action of D-600 blocking agent activated the electrical activity which suggests that smooth muscle cells have channels of mechanical sensitivity. Intracellular Ca2+ seems to participate in the contractile mechanism.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002417:Cattle; D066298:In Vitro Techniques; D007477:Ions; D008208:Lymphatic System / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D011188:Potassium / Q000494:pharmacology; D012964:Sodium / Q000494:pharmacology
D007477:Ions; D012964:Sodium; D011188:Potassium; D002118:Calcium
Ionnye mekhanizmy élektricheskoĭ aktivnosti gladkomyschechnykh kletok limfaticheskikh sosudov.