[In vitro effect of 5 alpha-androstane-3 beta, 17 beta diol on the liberation of follicle stimulating hormone (FSH) induced by LH-RH].
A continuous flow incubation (perifusion) was used to examine the effect of 5 alpha-androstane-3 beta, 17 beta diol 3 beta diol) on the release of FSH induced by LH-RH. Over a 3 h-period the 3 beta diol exerts inhibitory effects on male and female pituitaries at high dose (1 microgram/ml) and only on male pituitaries at low dose (100 ng/ml).
D015113:Androstane-3,17-diol / Q000494:pharmacology*; D000732:Androstanols / Q000494:pharmacology*; D000818:Animals; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D012737:Sex Factors
D000732:Androstanols; D015113:Androstane-3,17-diol; D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone
Influence in vitro du 5 alpha-androstane-3 beta, 17 beta diol sur la libération de l'hormone folliculostimulante (FSH) induite par LH-RH.