Tumor promoting and skin irritant diterpene esters of Euphorbia virgata latex.
The mouse ear irritant latex of E. virgata, has been found to contain various skin irritant and non-irritant esters of the diterpene ingenol. In cocarcinogenic assay on dorsal back skin of NMRI mice, acetone extract of this latex produces squamous cell papilloma. Using a combination of biologic and chemical separation techniques one of the initiator-promotor for skin carcinogenesis has been identified as 3-0-2 methyl-decanoyl ingenol.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002273:Carcinogens; D003043:Cocarcinogenesis; D004224:Diterpenes / Q000302:isolation & purification / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D003875:Drug Eruptions / Q000209:etiology; D005260:Female; D007509:Irritants; D007840:Latex / Q000032:analysis / Q000633:toxicity*; D019684:Magnoliopsida; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced*; D012878:Skin Neoplasms / Q000139:chemically induced*
D002273:Carcinogens; D004224:Diterpenes; D007509:Irritants; D007840:Latex; D015127:9,10-Dimethyl-1,2-benzanthracene