Studies on the male antifertility agent gossypol acetic acid. VI. Effect of gossypol acetic acid on the fertility of bonnet monkey. Macaca radiata.
Gossypol acetic acid (4 mg/day/5 days a week) suspended in Tonoferon tonic was given to male bonnet monkeys, Macaca radiata, by oral route for 3 months. Marked reduction in the sperm count/ejaculate and sperm motility were observed after gossypol treatment; both motility and sperm count/ejaculate returned to the normal level 8-10 weeks after termination of gossypol treatment. The citric acid and fructose levels in the semen of gossypol treated monkeys were not different from those of the controls.
D000818:Animals; D005298:Fertility / Q000187:drug effects*; D006072:Gossypol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008255:Macaca radiata; D008297:Male; D012661:Semen / Q000032:analysis; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013089:Spermatocidal Agents / Q000494:pharmacology*
D013089:Spermatocidal Agents; D006072:Gossypol; C028178:gossypol acetic acid