[Toxic effect of the combination of propranolol and phenformin combination in anesthetized dogs].
Phenformin (20 mg/kg subcutaneously) as well as propranolol (0.3 mg/kg. i.v.) induced an increase in blood lactate level in the normal anesthetized log; with phenformin a slight decrease in the arterial pH was noted. The combined administration of phenformin (20 mg/kg subcutaneously) and propranolol (0.3 mg/kg. i.v.) induced a more rapid increase in lactate level, a slight reduction of arterial pH and led to the death of the animals in all cases. After a chronic treatment by phenformin (20 mg/kg daily orally during 7 days, the administration of phenformin (20 mg/kg subcutaneously) induced lactic acidosis in 3 out of the 8 animals and death within 150 minutes. In the animals pretreated by phenformin, the combined administration of phenformin (20 mg/kg subcutaneously) and propranolol (0.3 mg/kg i.v.) caused the death of all the animals without the occurrence of lactic acidosis. These results point to the possible toxicity of the propranolol-phenformin combination.
D000758:Anesthesia; D000818:Animals; D004285:Dogs; D004347:Drug Interactions; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood; D010629:Phenformin / Q000008:administration & dosage / Q000633:toxicity*; D011433:Propranolol / Q000008:administration & dosage / Q000633:toxicity*
D007773:Lactates; D011433:Propranolol; D010629:Phenformin
Effet toxique de l'association propranolol-phenformine chez le chien anesthésié.