Evidence for normal cell-mediated immunity in scrapie-infected mice.
Comparisons between mixed lymphocyte cultures of splenocytes from scrapie-infected and normal mouse brain-inoculated control mice did not reveal any evidence of an impaired cell-mediated immune response in scrapie-infected mice. Likewise, mixed lymphocyte cultures of splenocytes from scrapie-infected and normal mice demonstrated that infected spleen cells had no scrapie-specific antigens on their surfaces. These data suggested that the absence of a detectable scrapie-specific immune response in infected mice was the result of an absence of an exposed scrapie-specific antigen and not due to any direct effect on the immune system.
D000818:Animals; D005260:Female; D007111:Immunity, Cellular; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D008934:Mitogens / Q000494:pharmacology; D012608:Scrapie / Q000276:immunology*; D012756:Sheep; D013154:Spleen / Q000276:immunology
D008934:Mitogens