Inhibition of actomyosin superprecipitation by an indole derivative of epinephrine.
A zwitterion indole metabolite of epinephrine, an inhibitor of actomyosin ATPase, has been shown to delay or prevent superprecipitation of cardiac and skeletal muscle actomyosin in a concentration-dependent manner. Inhibition of superprecipitation was not solely dependent on inhibition of actomyosin ATPase activity, suggesting that the ATPase inhibitor directly interfered with interaction of actin and myosin. Such an effect may occur by attachment of the indole derivative to free sulfhydryl groups involved in actin-myosin association as previously postulated for inhibition of ATPase activity.
D000205:Actomyosin; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors; D000263:Adenylate Kinase / Q000302:isolation & purification; D000818:Animals; D055598:Chemical Phenomena; D011232:Chemical Precipitation; D002621:Chemistry; D004837:Epinephrine / Q000031:analogs & derivatives*; D066298:In Vitro Techniques; D009132:Muscles / Q000032:analysis; D009206:Myocardium / Q000032:analysis; D011817:Rabbits; D051381:Rats
D000205:Actomyosin; D000263:Adenylate Kinase; D000251:Adenosine Triphosphatases; D004837:Epinephrine