Immunodeficiency in Down's syndrome: low levels of serum thymic factor in trisomic children.
The activity of thymus-dependent serum factor SF was significantly lower in 18 children wit Down's syndrome (DS) than in 14 matched controls. The percentage of circulating T lymphocytes forming E-rosettes was also low in DS. Together with the previous finding of immature of T lymphocytes in peripheral blood, the present data suggest that the basic immune defect of DS is failure in differentiation of peripheral post-thymic precursors to fully immunocompetent T lymphocytes resulting from lack of thymic hormonal factors.
D002675:Child, Preschool; D004314:Down Syndrome / Q000150:complications* / Q000235:genetics; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications / Q000276:immunology*; D007223:Infant; D012397:Rosette Formation; D013935:Thymic Factor, Circulating / Q000096:biosynthesis*; D013951:Thymus Hormones / Q000096:biosynthesis*; D014314:Trisomy
D013951:Thymus Hormones; D013935:Thymic Factor, Circulating