Keratosis palmaris et plantaris with clinodactyly. A distinct autosomal dominant genodermatosis.
Keratosis palmaris et plantaris and clinodactyly of the 5th finger was diagnosed in 11 members of a family with a typical pattern of autosomal dominant inheritance. It is concluded that both traits are probably the expression of a single mutant gene (p less than 0.001).
D002648:Child; D005385:Fingers / Q000002:abnormalities*; D005799:Genes, Dominant; D006801:Humans; D006945:Hyperhidrosis / Q000235:genetics; D007645:Keratoderma, Palmoplantar / Q000235:genetics*; D008297:Male; D009154:Mutation; D010375:Pedigree