Lipopolysaccharides: structural principles and biologic activities.
Structural principles of the three regions of the lipopolysaccharide molecule are briefly discussed. One of the recently available, chemically synthesized lipid A analogues has been tested for biologic activities. The preparation was found to be toxic, pyrogenic, and mitogenic. The amounts, however, needed for expression of effects similar to those of lipid A were about 500 times higher. These investigations are aimed at verifying the proposed structure of lipid A and at evaluating structure-activity relationships.
D000818:Animals; D008050:Lipid A / Q000276:immunology / Q000633:toxicity; D008070:Lipopolysaccharides / Q000032:analysis; D051379:Mice; D008934:Mitogens / Q000494:pharmacology; D011749:Pyrogens / Q000633:toxicity; D011817:Rabbits; D013329:Structure-Activity Relationship
D008050:Lipid A; D008070:Lipopolysaccharides; D008934:Mitogens; D011749:Pyrogens