Malignant transformation of early passage rodent cells by a single mutated human oncogene.
When linked to transcriptional enhancers, the mutant Ha-ras-1 gene from the T24 bladder carcinoma cell line induces the complete malignant transformation of early passage cells, while the normal Ha-ras-1 proto-oncogene only induces immortalization. Therefore, mutated Ha-ras-1 does not require a cooperating gene to trigger malignant conversion and ras genes may be involved in the process of tumorigenesis at an earlier stage than previously suspected.
D000818:Animals; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002478:Cells, Cultured; D005786:Gene Expression Regulation; D006801:Humans; D007621:Karyotyping; D009154:Mutation; D009857:Oncogenes; D000090063:Proto-Oncogene Mas; D051381:Rats