[Influence of prodigiozan, methyluracil and levamisole on the anti-inflammatory effect of nonsteroid antiphlogistics].
The efficacy of the combined use of immunostimulants and anti-inflammatory agents, such as acetylsalicylic acid, voltaren, indomethacin and naproxen was studied in carragenin-induced experimental inflammation. Noninbred albino mice of both sexes were used in the experiments. It was shown that prodigiosan as a therapeutic agent had a pronounced anti-inflammatory action. It potentiated the effect of voltaren used in a dose lower than the ED50 and did not change the anti-inflammatory activity of naproxen, indomethacin and acetylsalicylic acid used in the doses equal to the ED50. The potentiating effect of prodigiosan on voltaren was statistically significant Methyluracil used as a prophylactic agent had an anti-inflammatory effect. Levamisole used as a prophylactic agent or a therapeutic agent did not decrease the edema level. The anti-inflammatory effect of naproxen, indomethacin, acetylsalicylic acid and voltaren did not change, when the drugs were administered to the animals treated with methyluracil and levamisole.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002351:Carrageenan / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D005260:Female; D007108:Immune Tolerance / Q000187:drug effects; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D007978:Levamisole / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use*; D011354:Prodigiozan / Q000627:therapeutic use*; D014498:Uracil / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D000893:Anti-Inflammatory Agents; D011135:Polysaccharides, Bacterial; D007978:Levamisole; D014498:Uracil; C008378:6-methyluracil; D003520:Cyclophosphamide; D002351:Carrageenan; D011354:Prodigiozan
Vliianie prodigiozana, metiluratsila i levamizola na protivovospalitel'nyĭ éffekt nesteroidnykh antiflogistikov.