Effect of nicardipine in a hypertensive patient with diabetes mellitus.
Nicardipine, a new calcium antagonist, was given to an insulin-treated diabetic patient with severe hypertension that had resisted ordinary antihypertensive treatment. After substitution of treatment with nicardipine, his blood pressure decreased from 210/110 to 142/76 mmHg. Despite this significant decrease in blood pressure, the patient's renal blood flow, as estimated by endogenous creatinine clearance, increased. His daily requirement of insulin and his degree of proteinuria remained unchanged by the use of nicardipine.
D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D003922:Diabetes Mellitus, Type 1 / Q000150:complications*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D008875:Middle Aged; D009529:Nicardipine; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D012079:Renal Circulation / Q000187:drug effects
D002121:Calcium Channel Blockers; D009529:Nicardipine; D009543:Nifedipine