[First contact between blood and the arterial prosthesis. Study of the retention of the blood elements].
In order to characterize the nature of the interaction between arterial prostheses and their initial contact with blood, we propose the use of an in vitro test using labelled platelets and fibrinogen to measure the amount of the thrombotic matrix that is entrapped by the wall of the graft. The results have been confirmed by scanning electron microscopy. Polyester prostheses, whose healing process depends on the reorganisation of the thrombotic matrix, retains considerably more blood cells than the polytetrafluoroethylene microporous prostheses or the treated biological devices, whose fate, following implantation, maintains almost complete passivity.
D001672:Biocompatible Materials; D001705:Bioprosthesis; D001792:Blood Platelets / Q000378:metabolism*; D001807:Blood Vessel Prosthesis; D005337:Fibrin / Q000096:biosynthesis; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008854:Microscopy, Electron; D011091:Polyesters; D011138:Polytetrafluoroethylene; D013927:Thrombosis / Q000473:pathology; D014471:Umbilical Veins
D001672:Biocompatible Materials; D011091:Polyesters; D005337:Fibrin; D005340:Fibrinogen; D011138:Polytetrafluoroethylene
Premier contact sang/prothèse artérielle. Etude de la rétention des éléments sanguins.