[Synthetic inhibitors of serine proteinases. Part 24: Inhibition of trypsin, plasmin and thrombin by cyclic amides of N alpha-arylsulfonylamidinophenyl-glycines (author's transl)].
Cyclic amides of n alpha-arylsulfonyl (3-amidinophenyl)glycine are potent inhibitors of the serine proteinase trypsin, plasmin and thrombin. The weak inhibitory activity of the corresponding 4-amidinophenylglycine derivatives cannot be explained in terms of the structure-activity relationships established for benzamidine derivatives. It might be caused by steric hindrance of enzyme-inhibitor interactions.
D000577:Amides / Q000494:pharmacology*; D005341:Fibrinolysin / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship; D013449:Sulfonamides / Q000494:pharmacology*; D013917:Thrombin / Q000037:antagonists & inhibitors*; D014361:Trypsin Inhibitors
D000577:Amides; D013449:Sulfonamides; D014361:Trypsin Inhibitors; D013917:Thrombin; D005341:Fibrinolysin
Synthetische Inhibitoren der Serinproteinasen. 24. Mitteilung: Hemmung von Trypsin, Plasmin und Thrombin durch cyclische Amide N alpha-arylsulfonylierter Amidinophenylglycine.