Pharmacokinetics of spectinomycin in volunteers with renal insufficiency.
The pharmacokinetics of spectinomycin hydrochloride after 2 g intravenous doses were studied in ten volunteers with varying degrees of renal function. Mean peak serum concentration in 8 volunteers with renal insufficiency was 150.9 +/- (SD) 42.3 microgram/ml which was similar to 2 normal volunteers who had concentrations of 139 and 186 microgram/ml. Serum half-lives in the volunteers with renal insufficiency ranged from 4.7 to 29.3 h and increased as creatinine clearance decreased. Serum half-lives of the 2 normal volunteers were 1.5 and 1.7 h. Urine concentrations and percents of recovery were variable.
D000328:Adult; D006207:Half-Life; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D007700:Kinetics; D008875:Middle Aged; D000198:Spectinomycin / Q000378:metabolism*
D000198:Spectinomycin