A study of liver microsomal enzymes in rats following propoxur (Baygon) administration.
Groups of rats were given either propoxur, were left as untreated controls, or were given phenobarbital, DDT, chlordane or toxaphene which are known to induce liver microsomal detoxification enzymes. Microsomal enzyme activity was measured by testing the ability of liver homogenates to degrade EPN (O-ethyl O-(4-nitrophenyl) phenylphosphonothioate) to p-nitrophenol. The activity of aminopyrine-N-demethylase, cytochrome P-450 and p-nitroanisole-O-demethylase in liver homogenates of rats receiving propoxur was measured. Liver microsomal detoxification enzymes were not induced by propoxur exposure.
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004790:Enzyme Induction; D005260:Female; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D009575:Nitroanisole O-Demethylase / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology; D004849:Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester / Q000378:metabolism; D001074:Propoxur / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D004849:Phenylphosphonothioic Acid, 2-Ethyl 2-(4-Nitrophenyl) Ester; D003577:Cytochrome P-450 Enzyme System; D001074:Propoxur; D009575:Nitroanisole O-Demethylase; D000633:Aminopyrine N-Demethylase; D010634:Phenobarbital