The effect of disodium-chromoglykate on human serum neutrophil-chemotactic activity in antigen induced bronchospasm.
The prior administration of disodium-chromoglykate significantly inhibited the increase of serum neutrophil-chemotactic activity in house-dust induced bronchospasm. The serum neutrophil-chemotactic activity was probably mast-cell derived, because of the protective effect of disodium-chromoglykate and it may be related to Neutrophil-chemotactic Factor isolated in human pulmonary tissue. The moderately increased chemotactic activity after prior administration of disodium-chromoglykate in house-dust induced bronchospasm may derive from circulating basophils. The cellular chemotaxis (eosinophil, neutrophil) may has main importance in the pathophysiology of asthma bronchiale. The stimulation of eosinophil-associated effects may provide a new therapeutic line.
D000328:Adult; D000485:Allergens; D001986:Bronchial Spasm / Q000188:drug therapy* / Q000209:etiology; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D004391:Dust; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000276:immunology
D000485:Allergens; D004391:Dust; D004205:Cromolyn Sodium