[Cephalosporin and carbenicillin penetration into the tissues of rats with aseptic inflammation].
Two beta-lactam antibiotics with different serum protein binding were studied for penetration into the tissues of rats with aseptic inflammation. It was found that the pharmacokinetics of the drugs in the blood serum differed only in the elimination rate. The levels of the free fraction of cephaloridin were much higher than those of carbenicillin. The maximum concentrations of free cephaloridin in the inflammation exudate, intact and inflamed tissues and the areas under its pharmacokinetic curves were higher than those of carbenicillin. The elimination rate of both the drugs was the same for all the tissues studied.
D000042:Absorption; D000818:Animals; D001407:Bacillus / Q000187:drug effects; D001798:Blood Proteins / Q000378:metabolism; D002228:Carbenicillin / Q000378:metabolism*; D002511:Cephalosporins / Q000378:metabolism*; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D001798:Blood Proteins; D002511:Cephalosporins; D002228:Carbenicillin
Proniknovenie tsefalosporina i karbenitsillina v tkani krys s asepticheskim vospaleniem.