Amides of benzonorbornen-2-endo-amine with local anesthetic and other activities.
The synthesis of a series of amides derived from benzonorbornen-2-endo-amine is described. Some compounds showed a remarkable infiltration anesthesia in mice and a moderate hypotensive activity in rats. Antiarrhythmic activity in mice is also reported.
D000779:Anesthetics, Local / Q000138:chemical synthesis*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis; D000998:Antiviral Agents / Q000138:chemical synthesis; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D006339:Heart Rate / Q000187:drug effects; D051379:Mice; D009636:Norbornanes / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D000998:Antiviral Agents; D009636:Norbornanes