[Selective inactivation of specific T-suppressors immune to H-2 complex antigens and prevention of their generation in vivo by antisuppressor xenogenic antibodies].
Rats were immunized with mouse lymphocytes enriched by the absorption-elution technique with specific suppressor T-cells (STC) immune to antigens of the H-2 complex. The anti-suppressor sera (ASS) obtained being absorbed with mouse erythrocytes and lymph node cells killed in the presence of complement about 30 per cent of the STC-enriched cell population and inactivated the STC in vitro function in a selective fashion, not affecting the function of other T-cell subclasses, killers and MIF-producers, immune to the same H-2 antigens. The STC inactivating ASS action occurred partly in the absence of complement irrespective of the STC strain origin, STC immunological specificity in the H-2 system and the intensity of the STC activity. This ASS action was abolished by exhaustion of antibodies only with STC containing cell suspensions. In contrast, intact (non-enriched) mouse STC appeared to be able to induce a mixture of rat antibodies inactivating partly all three T-cell subclasses assayed. Infections of ASS to mice prevented them from the in vivo STC generation and gave rise to inhibition of the syngeneic tumor growth in the specifically preimmunized mice.
D000818:Animals; D003165:Complement System Proteins; D003602:Cytotoxicity, Immunologic; D006183:H-2 Antigens / Q000276:immunology*; D007106:Immune Sera / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains / Q000276:immunology; D012513:Sarcoma, Experimental / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D006183:H-2 Antigens; D007106:Immune Sera; D003165:Complement System Proteins
Izbiratel'naia inaktivatsiia spetsificheskikh T-suppressorov, immunnykh k antigenam kompleksa H-2, i predotvrashchenie ikh generatsii in vivo antisupressornymi ksenogennymi antitelami.