Canine ceroid lipofuscinosis, a model for ageing of the human isocortex.
In canine ceroid lipofuscinosis (one case studied), isocortical layer IIIab pyramidal cells develop spindle-shaped enlargements of their proximal axon filled with lipopigment, a feature that can be observed in juvenile and adult type of human neuronal ceroid lipofuscinosis and in normal ageing of the human isocortex as well.
D000375:Aging; D000818:Animals; D002540:Cerebral Cortex / Q000473:pathology* / Q000503:physiopathology; D004195:Disease Models, Animal; D004285:Dogs; D006801:Humans; D008297:Male; D009472:Neuronal Ceroid-Lipofuscinoses / Q000473:pathology*; D011712:Pyramidal Tracts / Q000473:pathology