Enzymatic sulphation of bile salts in man. Bile salt sulphotransferase activity in human adrenal.
Enzymatic sulphation of bile salts was identified in cytosol prepared from human adrenal tissue. Unconjugated lithocholate was sulphated at a slightly greater rate than glycolithocholate. Chenodeoxycholate and deoxycholate were sulphated at the 7- and 12-OH positions, respectively, but no disulphate formation from these bile salts was found. The physiological implications of these results are discussed.
D000311:Adrenal Glands / Q000201:enzymology*; D000328:Adult; D001647:Bile Acids and Salts / Q000378:metabolism; D002478:Cells, Cultured; D002635:Chenodeoxycholic Acid / Q000378:metabolism; D002793:Cholic Acids / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism*; D003687:Dehydroepiandrosterone / Q000494:pharmacology; D004951:Esterification; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D015238:Sulfotransferases; D013466:Sulfurtransferases / Q000378:metabolism*
D001647:Bile Acids and Salts; D002793:Cholic Acids; D002635:Chenodeoxycholic Acid; D003687:Dehydroepiandrosterone; D013466:Sulfurtransferases; D015238:Sulfotransferases; C019786:bile-salt sulfotransferase