Induction and characterization of suppressor T cells and soluble factors with modified timothy grass pollen AgB.
Previous studies demonstrated that antigen B (AgB), a major antigen of timothy grass pollen, modified by photooxidation (Ox-AgB) does not react with rabbit, human, or mouse antibodies directed against AgB and does not induce antibodies reactive with either native or modified AgB. However, immunization of mice with Ox-AgB in alum induces significant T helper cell activity. In this review, we describe the conditions and kinetics for Ox-AgB induction of T suppressor cells, the secretion of AgB-specific T suppressor factor (TSF), and the partial purification of AgB-specific TSF.
D000327:Adsorption; D000818:Animals; D000941:Antigens; D001402:B-Lymphocytes / Q000276:immunology; D002846:Chromatography, Affinity; D005620:Freund's Adjuvant / Q000494:pharmacology; D006801:Humans; D007116:Immunization, Passive; D007700:Kinetics; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis; D011058:Pollen / Q000276:immunology*; D011817:Rabbits; D012995:Solubility; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000941:Antigens; D005620:Freund's Adjuvant