[Possible regulatory importance of cellular sulfhydryl groups and reduction metabolic pathways for the activation of human blood platelets].
The activation of the blood platelets is the prerequisite for their participation in physiological and pathological intravasal processes. An aimed influence on the distinct functions of the blood platelets presumes an exact knowledge about course and regulation of the activation of the platelets. Investigations on glucose-6-phosphate-dehydrogenase-deficient platelets and on the effect of glutathione-oxidizing substances on normal platelets showed references to a regulatory significance of the cellular thiol/disulphide state in the process of activation. In this case particularly the arachidonic acid balance and the SH/SS-state of platelet proteins seem to be in close connection with reductive ways of metabolism.
D001095:Arachidonic Acids / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism*; D003958:Diamide / Q000494:pharmacology; D004734:Energy Metabolism / Q000187:drug effects; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood; D005978:Glutathione / Q000097:blood; D006801:Humans; D009712:Nucleotides, Cyclic / Q000097:blood; D010084:Oxidation-Reduction; D010974:Platelet Aggregation / Q000187:drug effects; D013438:Sulfhydryl Compounds / Q000097:blood*
D001095:Arachidonic Acids; D009712:Nucleotides, Cyclic; D013438:Sulfhydryl Compounds; D003958:Diamide; D005954:Glucosephosphate Dehydrogenase; D005978:Glutathione
Mögliche regulatorische Bedeutung zellulärer Sulfhydrylgruppen und reduktiver Stoffwechselwege für die Aktivierung menschlicher Blutplättchen.