Mutagenic activities of simple nitrofuran derivatives. I. Comparison of related compounds in the phage inductest, chloroplast-bleaching and bacterial-repair and mutagenicity tests.
Several simple furan and nitrofuran compounds were tested for mutagenicity and related biological activities, in the Ames test, the bacterial repair test, the prophage-induction test and the chloroplast-bleaching test. Only those compounds having the nitro-group were found to be active in the test. If the nitro-group was in the beta instead of the alpha position, the mutagenic activity was much reduced (0.3 revertants per nanomole, the other simple nitrofurans producing 5-15 reversions per nanomole, as did 5-nitrofuran and 5,2-dinitrofuran). The vinyl-group-containing compound, 5-nitro-2-furylacrylic acid, was by one decadic order more effective both in the Ames test and in the prophage-induction test. In the repair tests all nitrofurans displayed a much higher dependence on the recA-repair system than on the uvrA system. For 2 compounds, the dinitrofuran and, especially, the 5-nitrofuraldehyde, the urA cells were even less sensitive than the wild-type cells.
D000818:Animals; D010582:Bacteriophage lambda / Q000254:growth & development; D002736:Chloroplasts / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics; D005056:Euglena gracilis / Q000235:genetics; D009152:Mutagenicity Tests; D009153:Mutagens; D009581:Nitrofurans / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000235:genetics; D014775:Virus Activation
D009153:Mutagens; D009581:Nitrofurans