[Transcription peculiarities of nuclear genome in different stages of liver regeneration. Activity of cytosol protein factor on the activation of different forms of nuclear DNA-dependent RNA-polymerases].
Subfraction P containing a "regeneration factor" which controls the activity of three forms of DNA-dependent RNA-polymerase was isolated from rat liver hepatocyte cytosol one hour after partial hepatectomy. The factor exerts differentiated effects towards purified enzyme: it increases the activity of RNA-polymerase I and inhibits that of RNA polymerases II and III in a system with the enzyme from resting liver. In a heterologous system, the effect of the factor is nonspecific.
D000818:Animals; D004247:DNA / Q000235:genetics / Q000378:metabolism*; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D006498:Hepatectomy; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008115:Liver Regeneration; D008297:Male; D011506:Proteins / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D014158:Transcription, Genetic
D011506:Proteins; D004247:DNA; D012321:DNA-Directed RNA Polymerases
Osobennosti transkriptsii iadernogo genoma na rannikh étapakh regeneratsii pechenii. Deĭstvie tsitozol'nogo belkovogo faktora na aktivnost' razlichnykh form iadernoĭ DNK-zavisimoĭ RNK-polimerazy.