Carcinoma of the hand: a 20-year experience.
We reviewed our 20-year experience with cutaneous carcinoma of the hand and identified 70 cases (basal cell 23%, squamous cell 77%). The documented risk factors included solar radiation, trauma, and irradiation. Lesions were treated surgically with amputation, excision, skin graft, or flap closure, and nonsurgically with cryosurgery, curettage, 5-fluorouracil, or irradiation. The recurrence was lower with surgical treatment (3%) than with nonsurgical (33%). Regional lymphadenectomy was required in four patients for metastatic squamous cell carcinoma. Recurrence was greater (9%) and metastasis more common (38%) in patients with Marjolin's type of secondary squamous cell carcinoma than with solar-induced lesions. Cause is an important factor in outcome and should be considered in initial treatment and long-term management.
D000328:Adult; D000368:Aged; D002280:Basal Cell Carcinoma / Q000209:etiology* / Q000601:surgery / Q000628:therapy; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000601:surgery / Q000628:therapy; D003452:Cryosurgery; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D005500:Follow-Up Studies; D006225:Hand; D006230:Hand Injuries / Q000150:complications; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011832:Radiation Injuries / Q000150:complications; D012878:Skin Neoplasms / Q000209:etiology* / Q000601:surgery / Q000628:therapy; D013472:Sunlight / Q000009:adverse effects
D005472:Fluorouracil