Sex differences in the regulation of experimentally induced autoantibodies in (NZB x NZW)F1 mice.
The ability to induce autoantibodies to erythrocytes in male and female (NZB x NZW)F1 mice was examined. Female (NZB x NZW)F1 mice were shown to produce significantly more autoantibody than the male (NZB x NZW)F1 mice. The regulation of this experimentaly induced autoantibody was studied by examining the ability of male and female (NZB x NZW)F1 mice to generate antigen-specific suppressor cells. A sex difference was found in the ability to generate these suppressor cells. Male mice generated antigen-specific suppressor cells in response to rat RBC which were capable to suppressing the experimental induction of red cell autoantibodies whereas female mice were unable to generate those antigen-specific suppressor cells.
D000373:Agglutinins / Q000032:analysis; D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D003298:Coombs Test; D003433:Crosses, Genetic; D005260:Female; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB; D012727:Sex Characteristics; D013154:Spleen / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000373:Agglutinins; D001323:Autoantibodies