[Cefoperazone--a new cephalosporin antibiotic with broader spectrum of activity].
Concentration of Cefoperazone in serum and urine was determined after 1g (bolus injection) and 2g drip-infusion over a 30-minute-period in 10 healthy volunteers. The pharmacokinetic analysis was performed using an open 3-compartment model. Renal clearance was determined in three volunteers and indicates an expansive extrarenal elimination rate. 31 patients mainly with severe bronchopulmonary infections were treated with 2.0--6.0 g/day of Cefoperazone. The therapeutic results were favourable, the toleration of the drug was good.
D000328:Adult; D000368:Aged; D002438:Cefoperazone; D002511:Cephalosporins / Q000009:adverse effects / Q000097:blood / Q000627:therapeutic use* / Q000652:urine; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D014552:Urinary Tract Infections / Q000188:drug therapy*
D002511:Cephalosporins; D002438:Cefoperazone
Cefoperazon--ein neues Cephalosporin-Antibiotikum mit erweitertem Wirkungsspektrum.