[Urinary excretion of toxic peptides in patients with thermal burns].
A fraction of toxic ninhydrin-positive substances was isolated from urine of healthy persons and of the patients with acute burn toxemia using a multi-step technique, which involved ion exchange chromatography on Dowex resins, gel filtration on Sephadex G-15 and ultrafiltration on Diaflo UM-0.5. The daily excretion of the substances was about 4-fold higher in the patients as compared with healthy persons. The fraction contained basic peptides with molecular masses of 500-2,000 daltons. The total toxicity of these peptide was higher by an order of magnitude in the patients with burns as compared with healthy persons.
D000818:Animals; D001681:Biological Assay; D002056:Burns / Q000652:urine*; D002850:Chromatography, Gel; D002855:Chromatography, Thin Layer; D006801:Humans; D007928:Lethal Dose 50; D051379:Mice; D009555:Ninhydrin; D010455:Peptides / Q000652:urine*; D014118:Toxins, Biological / Q000652:urine*
D010455:Peptides; D014118:Toxins, Biological; D009555:Ninhydrin
Ekskretsiia toksicheskikh peptidov s mochoĭ u bol'nykh s termicheskimi ozhogami.