[Critical analysis of the fractional value of a bio-artificial pancreas (hollow-fiber model)].
The implantation of a bio-artificial pancreas, in a totally depancreated dog, allowed to underline the functional limits of this system. This study would want to explain in vitro a defect of the bio-distributor artificial picked out in vivo. Double stimulation by glucose have been realised composing the conventional system of perifusion (Millipore) to the artificial bio-distributor. While the insulin secretion increases directly at every raise of the glucose concentration in the conventional systems, it seems to hot move during the first test with the artificial biodistributor of insulin. It increases during the second phase of rest and reaches its maximum during the second phase of raise. The insulin concentration represents at the end of the test approximatively 1/5 of this obtained by the conventional system (the experimental conditions and the islets number are the same in the two cases).
D000818:Animals; D001187:Artificial Organs; D004285:Dogs; D005069:Evaluation Studies as Topic; D005947:Glucose / Q000494:pharmacology; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism; D016381:Islets of Langerhans Transplantation; D010179:Pancreas; D051381:Rats
D007328:Insulin; D005947:Glucose
Analyse critique de la valuer fonctionnelle d'un pancréas bio-artificiel (modèle à fibres creuses).