The sign of Leser-Trélat associated with primary lymphoma of the brain.
The sign of Leser-Trélat has been defined as the sudden appearance of seborrheic keratoses in number and/or size in association with an underlying malignancy. There have been only thirty-two reported cases of the sign of Leser-Trélat since it was first described in 1984. This is the first known case of primary lymphoma of the brain associated with this sign. Until Dantzig's review of the literature in 1973, the only tumor type associated with this sign had been adenocarcinomas of the gastrointestinal tract and the genitourinary tract. Since that time there have been only nine cases reported that were not adenocarcinomas; of those, only four cases have been lymphoproliferative malignancies. We wish to emphasize the need for further reports of this sign to better characterize it and to make physicians more aware of the association between this dermatologic sign and an internal malignancy.
D000368:Aged; D001932:Brain Neoplasms / Q000150:complications*; D002280:Basal Cell Carcinoma / Q000150:complications*; D005153:Facial Neoplasms / Q000150:complications*; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000150:complications*; D012878:Skin Neoplasms / Q000150:complications*