Reversal by nalbuphine of respiratory depression caused by fentanyl.
In 60 ASA class I or II patients given intravenous fentanyl for elective operations in doses large enough to produce postoperative respiratory depression, the intravenous administration of 20 mg nalbuphine resulted in prompt reversal of respiratory depression without loss of analgesia.
D000328:Adult; D001784:Blood Gas Analysis; D001794:Blood Pressure; D005260:Female; D005283:Fentanyl / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009019:Morphinans / Q000494:pharmacology*; D009266:Nalbuphine / Q000494:pharmacology*; D010149:Postoperative Pain / Q000188:drug therapy; D011184:Postoperative Period; D012119:Respiration / Q000187:drug effects*; D013990:Tidal Volume
D009019:Morphinans; D009266:Nalbuphine; D005283:Fentanyl