Lack of behavioural teratogenic effect of phenytoin in rats.
A small battery of tests (static and air-righting reflexes, eye opening and a narrowing bridge test) was used to investigate the behavioural teratogenic potential of prenatal oral exposure (day 7-19 of gestation) of up to 100 mg phenytoin/kg/day to female rats. No treatment-related effects upon mother or offspring were detected. In order to validate our narrowing bridge test, neonatal old rats were tested over 4 weeks following early postnatal exposure to acrylamide (5 X 50 mg/kg/day i.p.). These animals showed a severe transient deficit compared with saline-treated controls. Despite the absence of an effect using phenytoin, the narrowing bridge test is considered worthy of further validation.
D020106:Acrylamide; D000178:Acrylamides / Q000494:pharmacology; D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn; D001522:Behavior, Animal / Q000187:drug effects*; D005260:Female; D008297:Male; D008431:Maternal-Fetal Exchange; D010672:Phenytoin / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012098:Reproduction / Q000187:drug effects; D012737:Sex Factors
D000178:Acrylamides; D020106:Acrylamide; D010672:Phenytoin