Ethylene oxide allergy in a dialysis center: prevalence in hemodialysis and peritoneal dialysis populations.
Chronic hemodialysis (HD) and peritoneal dialysis (PD) patients in one dialysis center were examined for (EO)-related sensitization. Five of 56 (8.9%) HD patients and 0 of 30 PD patients skin tested with a conjugate of human serum albumin (HSA) and EO had positive skin prick tests. The sera of 13 of 107 (12.1%) HD patients including sera from 5 patients with negative skin tests were positive in an EO-HSA radioallergosorbent test (RAST). Sensitized patients in this population did not experience allergic-type reactions during hemodialysis. There were no positive EO-HSA RAST results which could be ascribed to PD. Non-specific cutaneous responsiveness of the renal failure patients was compared with that of normal adult subjects by the use of skin prick tests with codeine phosphate and histamine phosphate. A significantly reduced responsiveness is present in chronic renal failure patients which would be expected to lower the sensitivity of the diagnostic skin test by comparison with the RAST.
D000328:Adult; D000368:Aged; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000453:epidemiology; D005027:Ethylene Oxide / Q000009:adverse effects* / Q000276:immunology; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced* / Q000175:diagnosis / Q000453:epidemiology; D007073:Immunoglobulin E / Q000302:isolation & purification; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D011852:Radioallergosorbent Test; D006435:Renal Dialysis / Q000009:adverse effects*; D012709:Serum Albumin; D012882:Skin Tests
D012709:Serum Albumin; D007073:Immunoglobulin E; D005027:Ethylene Oxide