Stimulation and inhibition of hematopoiesis by the MLC reaction.
The effect of an MLC reaction on mouse and human hematopoiesis in vitro was studied. The growth of murine T- and B-lymphocyte colonies as well as myeloid colonies was enhanced during early days of MLC, while a marked decrease of colony formation was evident starting from day +4 of MLC. Allogeneic reaction initially stimulates hematopoiesis, while on its peak a marked inhibition of the proliferation and differentiation of progenitor cells occurs.
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology; D001853:Bone Marrow; D002470:Cell Survival; D002478:Cells, Cultured; D006410:Hematopoiesis; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000166:cytology