[Blood estradiol level and G2-chalone content in the vaginal mucosa in rats of different ages].
17 beta-Estradiol level was higher in the blood serum of rats aged 14 to 16 months with regular estral cycles during all the phases as compared to that in 3- to 4-month-old female rats. The latter ones had a higher vaginal mucosa G2-chalone concentration. The level of the vaginal mucosa G2-chalone decreased in young rats 12 hours after subcutaneous benzoate-estradiol injection (1 micrograms/100 g body weight) to ovariectomized animals but increased in 14- to 16-month-old female rats. One year following ovariectomy the vaginal mucosa G2-chalone level was lower than in young and aged female rats 2 weeks after surgery. Possible role of age-associated disturbances of the regulatory cell proliferation stimulant (estrogen) and its inhibitor (chalone) interactions in neoplastic target tissue transformation is discussed.
D000367:Age Factors; D000818:Animals; D004958:Estradiol / Q000097:blood*; D004971:Estrus; D005260:Female; D006131:Growth Inhibitors / Q000378:metabolism*; D009092:Mucous Membrane / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D014621:Vagina / Q000378:metabolism*
D006131:Growth Inhibitors; D004958:Estradiol
Uroven' éstradiola v krovi i G2-keĭlona v slizistoĭ obolochke vlagalishcha u krys raznogo vozrasta.