[Effect of sodium dipropylacetate on experimental convulsions produced by pentetrazole and picrotoxin].
Sodium dipropylacetate, an anticonvulsant used in human therapy, gives a more efficient protection against convulsions elicited by pentetrazol than by picrotoxin. In the case of picrotoxin induced convulsive seizures where there is an alteration at the GABA receptor level, ther is a lack of efficiency after nDPA treatment which increases GABA at the synaptic level. DPA is more effective against pentetrazol convulsive seizures where no direct participation of GABAergic receptors seems to occur. The efficiency of potentialisation of GABAergic mediation is a function of the mechanism by which the seizure is triggered.
D000818:Animals; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D014635:Valproic Acid / Q000627:therapeutic use*
D010433:Pentylenetetrazole; D010852:Picrotoxin; D014635:Valproic Acid
Effet du dipropylacétate de sodium sur les crises convulsives expérimentales produites par le pentétrazole et la picrotoxine.