Are the climbing fibres essential for the Purkinje cell inhibitory action?
Following an almost total chemical lesion of the inferior olive, the inhibitory control of the cerebellar Purkinje cells upon their target neurones, mainly in Deiters nucleus, remains practically unchanged. This result is at variance with some recent findings having important implications in the cerebellar theories of motor learning.
D000818:Animals; D002531:Cerebellum / Q000502:physiology*; D006246:Harmaline / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009536:Niacinamide / Q000494:pharmacology; D009847:Olivary Nucleus / Q000502:physiology*; D011689:Purkinje Cells / Q000187:drug effects / Q000502:physiology*; D011725:Pyridines / Q000494:pharmacology; D051381:Rats
D011725:Pyridines; C010835:3-acetylpyridine; D009536:Niacinamide; D006246:Harmaline