Intra-individual consistency of prednisolone kinetics during long-term prednisone treatment.
Eleven patients on long-term prednisone treatment were studied on two occasions separated by 45 to 325 days. In 10 patients the total body clearance of prednisolone only changed about 10%. In one case a 78.5% decrease was observed after stopping treatment with rifampicin and isoniazide. No association was found between the prednisone dose rate (mg/kg per month), patient age or mean endogenous plasma hydrocortisone level and prednisolone clearance/kg. The results indicate considerable intra-individual consistency of prednisolone kinetics if other conditions are not changed.
D000328:Adult; D005260:Female; D006801:Humans; D007206:Individuality; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011239:Prednisolone / Q000378:metabolism*; D011241:Prednisone / Q000008:administration & dosage*
D011239:Prednisolone; D011241:Prednisone