The influence of naturally occurring suppressor cells of systemic graft versus host reaction (GvHR in fetal and newborn mice.
The early symptom (splenomegaly on day 7) of a graft versus host reaction (GvHR), induced in F1 fetal and newborn mice on day 0 or +1 after birth, is significantly reduced as a result of action of suppressor cells in comparison with 3-day-old recipients. However, late symptoms of GvHR, measured by a body-weight-gain assay and mortality, are similar in the recipients injected with parental spleen cells either on day 0 or +3. An existence of contra suppressive factor(s) operating in newborn early after birth is suggested.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight; D005260:Female; D005333:Fetus / Q000276:immunology*; D006087:Graft vs Host Reaction; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D009026:Mortality; D011247:Pregnancy; D013163:Splenomegaly / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*