Twice-daily cimetidine does not increase gastric bacterial flora.
Thirty patients with peptic ulcer (20 duodenal, 10 gastric) underwent glucose-hydrogen (H2) breath tests before and after 6 weeks treatment with cimetidine, 400 mg twice daily. For the group as a whole, basal breath H2 and integrated H2 output over a 2.5 hr test period was unchanged by cimetidine treatment. We conclude that there was no evidence of significant gastric bacterial colonization following twice daily cimetidine treatment.
D000328:Adult; D000368:Aged; D001419:Bacteria; D001944:Breath Tests; D002927:Cimetidine / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000188:drug therapy; D006801:Humans; D006859:Hydrogen / Q000032:analysis; D008875:Middle Aged; D013270:Stomach / Q000382:microbiology*; D013276:Stomach Ulcer / Q000188:drug therapy
D006859:Hydrogen; D002927:Cimetidine