The effect of cadmium on steroidogenesis by testes of the rainbow trout, Salmo gairdneri.
Testes of the rainbow trout were incubated in the presence of 0, 0.05, 0.5 and 5 mM cadmium (Cd). Production of those steroids measured was stimulated by 0.05 and 0.5 mM cadmium. Yields of testosterone (T) and 11 beta-hydroxytestosterone (beta) were significantly increased at these concentrations, but there was little effect on glucuronyl transferase and 11 beta-hydroxysteroid dehydrogenase enzyme activities. Cd-induced alteration of the hormonal balance may result in perturbation of reproductive development.
D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D006915:Hydroxytestosterones / Q000096:biosynthesis*; D066298:In Vitro Techniques; D008297:Male; D013737:Testis / Q000187:drug effects*; D013739:Testosterone / Q000031:analogs & derivatives* / Q000096:biosynthesis*; D014337:Trout
D006915:Hydroxytestosterones; D002104:Cadmium; C015529:testosterone glucuronate; C037914:11-hydroxytestosterone; D013739:Testosterone; C003600:11-ketotestosterone