Antibiotic distribution in normal and osteomyelitic bone.
Antibiotics are able to penetrate normal and osteomyelitic bone in a fashion that permits concentrations equivalent to those found in the serum following intravenous administration. There is no osseous barrier or gradient in osseous tissue to antibiotic penetration.
D000617:Aminoglycosides / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D002199:Capillary Permeability / Q000187:drug effects; D002511:Cephalosporins / Q000378:metabolism; D004058:Diffusion; D005110:Extracellular Space / Q000378:metabolism; D007700:Kinetics; D010019:Osteomyelitis / Q000378:metabolism*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002511:Cephalosporins