Cardiac and antiarrhythmic effects of imipramine in patients with ventricular arrhythmias.
Imipramine is an effective antiarrhythmic agent against ventricular arrhythmias and complex features of ventricular premature depolarizations at plasma concentrations ranging from 100 to 400 ng per ml. Imipramine's effects on the electrocardiogram are similar to procaine amide and quinidine producing a slight prolongation of PR and QRS intervals. A relatively long half-life of elimination, mean = 9 + 3.7 hours, and no significant adverse effect on left ventricular function suggest imipramine will be useful even for patients with depressed cardiac function.
D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D004562:Electrocardiography; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D007099:Imipramine / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*
D000889:Anti-Arrhythmia Agents; D007099:Imipramine