Identification of a high-affinity binder for estradiol and a low-affinity binder for testosterone in Coccidioides immitis.
Coccidioides immitis cytosol contains a specific estrogen binder with kinetic characteristics (Kd = 2.1 X 10(-8) to 3.7 X 10(-8) M; n = 0.5 to 1.56 pmol/mg of protein) appropriate for interaction with levels of estrogen encountered during pregnancy. The Kd of a separate androgen binder (ca. 10(-7) M) is probably too low to allow interaction with physiological levels of testosterone.
D003045:Coccidioides / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism*; D007700:Kinetics; D013739:Testosterone / Q000378:metabolism*
D004967:Estrogens; D013739:Testosterone