Effects of salicylates and other nonsteroidal anti-inflammatory drugs on articular cartilage.
According to in vivo experimental data, salicylates and several other nonsteroidal anti-inflammatory agents suppress proteoglycan biosynthesis in normal and degenerating articular cartilage. Therapeutic levels of aspirin in vivo had a similar adverse effect on degenerating cartilage, as noted in two canine models of osteoarthritis and cartilage atrophy. Because the effective daily antirheumatic dose of nonsteroidal anti-inflammatory drugs is lower than that of salicylates, these drugs may have less negative effects on degenerating articular cartilage. However, clinical significance cannot be extrapolated from these experimental data.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001241:Aspirin / Q000494:pharmacology; D001284:Atrophy; D002358:Cartilage, Articular / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D004285:Dogs; D005109:Extracellular Matrix / Q000187:drug effects; D006025:Glycosaminoglycans / Q000037:antagonists & inhibitors; D007213:Indomethacin / Q000494:pharmacology; D010003:Osteoarthritis / Q000188:drug therapy; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011509:Proteoglycans / Q000037:antagonists & inhibitors*; D012459:Salicylates / Q000494:pharmacology* / Q000627:therapeutic use; D013462:Sulfur Radioisotopes; D013467:Sulindac / Q000494:pharmacology; D014574:Uronic Acids / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D006025:Glycosaminoglycans; D011448:Prostaglandin Antagonists; D011509:Proteoglycans; D012459:Salicylates; D013462:Sulfur Radioisotopes; D014574:Uronic Acids; D013467:Sulindac; D001241:Aspirin; D007213:Indomethacin