Carcinoma of pancreas associated with the 5q-syndrome.
A female patient with the 5q-syndrome (refractory macrocytic anemia with deletion of the long arm of No. 5 chromosome) was followed-up for a period of 33 months and developed a carcinoma of pancreas. Until death she showed no signs of leukemic transformation. This association has not been described, and the genetic predisposition of 5q-patients to malignancies is discussed.
D000230:Adenocarcinoma / Q000235:genetics; D000328:Adult; D000748:Anemia, Macrocytic / Q000235:genetics; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D002905:Chromosomes, Human, 4-5; D005260:Female; D006801:Humans; D010190:Pancreatic Neoplasms / Q000235:genetics*; D013577:Syndrome