Effects of reserpinization on the electrolytes distribution in inner ear fluids of guinea pig.
Reserpine (2 mg/kg and 10 mg/kg, i.p.), an adrenergic blocker, was administered to normal guinea pigs, and samples of serum, CSF, scala tympani perilymph, scala vestibuli perilymph and cochlear endolymph were collected. The concentrations of Na and K in these fluids were then assessed to observe electrolyte distributions. Both Na and K concentrations were reduced in serum. In CSF, the Na concentration was markedly depressed, while the K concentration remained unchanged. Scala tympani perilymph showed a pattern of electrolyte changes similar to that in CSF. In scala vestibuli perilymph, the Na concentration was unaltered, but the K concentration was lowered. Cochlear endolymph exhibited no change of the Na concentration but there was a marked decrease in the K concentration. These changes are thought to be attributable to the indirect blockage of energy producing systems in membrane transport in the inner ear by the reserpine-induced depletion of catecholamines.
D000818:Animals; D003051:Cochlea / Q000187:drug effects; D004710:Endolymph / Q000187:drug effects; D006168:Guinea Pigs; D007761:Labyrinthine Fluids / Q000187:drug effects*; D010498:Perilymph / Q000187:drug effects; D011188:Potassium / Q000378:metabolism; D012110:Reserpine / Q000494:pharmacology*; D012533:Scala Tympani / Q000187:drug effects; D012964:Sodium / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D012110:Reserpine; D012964:Sodium; D011188:Potassium