Effect of ascorbic acid on ulceration in alkali-burned corneas.
Alkali-burned corneas were treated with 2% ascorbic acid. Topical applications and subconjunctival injections were given for 32 days. Treatment with ascorbic acid significantly decreases the incidence of corneal ulcerations and perforations compared to the control group that received the vehicle. These results confirm previous studies and strongly suggest that ascorbic acid presents a potential for use in the alkali-burned human eye.
D000818:Animals; D001205:Ascorbic Acid / Q000627:therapeutic use*; D002057:Burns, Chemical / Q000188:drug therapy*; D003320:Corneal Ulcer / Q000139:chemically induced* / Q000188:drug therapy; D005126:Eye Burns / Q000139:chemically induced* / Q000188:drug therapy; D011817:Rabbits; D012972:Sodium Hydroxide / Q000633:toxicity*
D012972:Sodium Hydroxide; D001205:Ascorbic Acid