Brain injury by ischemic anoxia: hypothesis extension--a tale of two ions?
The understanding of the pathophysiology of cerebral ischemic anoxia depends on elucidation of cellular neuronal changes during this event and under conditions of cardiopulmonary resuscitation. Current knowledge of these metabolic developments is reviewed, and a hypothesis of the role of iron in this situation is presented.
D000818:Animals; D001921:Brain / Q000378:metabolism; D002545:Brain Ischemia / Q000378:metabolism* / Q000628:therapy; D002118:Calcium / Q000378:metabolism*; D004285:Dogs; D005609:Free Radicals; D006801:Humans; D002534:Hypoxia, Brain / Q000378:metabolism* / Q000628:therapy; D007501:Iron / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D012151:Resuscitation
D005609:Free Radicals; D008054:Lipid Peroxides; D007501:Iron; D010100:Oxygen; D002118:Calcium