Coding strategy differences between constant and variable segments of immunoglobulin genes.
Vertebrate immunoglobulin (Ig) mRNAs reveal intraspecies variation in codon usage distinct from that seen with yeast or bacterial genes. Comparison of all available Ig gene sequences shows that %(G + C) in codon position III is consistently lower in variable (V) segments than in constant (C) segments. I find an even lower %(G + C) in the hypervariable domains of V segments. This analysis suggests that base substitution in Ig genes correlates positively with local A + T content.
D000489:Alligators and Crocodiles; D000818:Animals; D002645:Chickens; D003062:Codon; D005796:Genes; D014644:Genetic Variation; D006801:Humans; D007127:Immunoglobulin Constant Regions / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D007136:Immunoglobulins / Q000235:genetics*; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D003062:Codon; D007127:Immunoglobulin Constant Regions; D007135:Immunoglobulin Variable Region; D007136:Immunoglobulins; D012333:RNA, Messenger