Autoradiographic localization of 5-HT1 receptors to human and canine basilar arteries.
Autoradiographic techniques were used to identify serotonergic binding sites in human and canine basilar artery segments. 5-HT1, but not 5-HT2, receptors could be localized to the medial layer of the vascular wall using both [3H]LSD and [3H]5-HT. The identification of 5-HT1 binding sites in human and canine basilar arteries provides anatomical evidence that the 5-HT1 receptor mediates vasoconstriction in these major intracranial vessels.
D000818:Animals; D001345:Autoradiography; D001488:Basilar Artery / Q000378:metabolism* / Q000502:physiology; D004285:Dogs; D006801:Humans; D008238:Lysergic Acid Diethylamide / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D011985:Receptors, Serotonin / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D013045:Species Specificity; D014661:Vasoconstriction
D011985:Receptors, Serotonin; D012701:Serotonin; D008238:Lysergic Acid Diethylamide