[Insomnia induced by P-chlorophenylalanine in cats. Its reversibility by intraventricular injections of indolamines].
Intraventricular injection of 250 microgram of 5 HTP induces both slow wave and paradoxical sleep, after 20-60 min. latencies, in insomniac Cats pretreated with P-chlorophenylalanine. Direct injections of 5 HTP in several brain stem structures do not induce sleep. The long latency or paradoxical sleep induction and its suppression with chloramphenicol suggest that indolamines are not directly responsible for paradoxical sleep, but that they act by controlling the synthesis and/or the liberation in the periventricular system of some specific paradoxical sleep inducing factor.
D006916:5-Hydroxytryptophan / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D005260:Female; D010134:Fenclonine / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D012890:Sleep / Q000187:drug effects*; D007319:Sleep Initiation and Maintenance Disorders / Q000139:chemically induced
D006916:5-Hydroxytryptophan; D010134:Fenclonine
L'insomnie provoquée par la P-chlorophénylalanine chez le Chat. Sa réversibilité par l'injection intraventriculaire d'indolamines.