Gestational macromastia.
Gestational macromastia is a rare entity. Causes are many and include excess hormonal production, hormonal imbalance, and decreased hormonal catabolism. Documentation of elevated serum prolactin levels and tissue hormonal receptor levels brings new light to this pathologic condition. Pharmacologic measures are not recommended because of lack of effectiveness and possible teratogenic side effects. Primary therapy should consist of local measures, such as breast support, bed rest, and analgesics. If this fails and progression is inevitable, we recommend total mastectomy with provision made for reconstruction and nipple banking. Skin flaps must be thin, and all breast tissue must be removed, otherwise the pathologic condition will continue during the ensuing months of the pregnancy and will recur with each successive pregnancy. Abortion is feasible, but this leaves the patient in need of a reduction or total mastectomy at a later date, and thus is not recommended as a primary line of therapy. If the patient progresses to delivery without complication, a reduction mammoplasty can be considered but only if no future pregnancies are planned.
D000293:Adolescent; D001940:Breast / Q000473:pathology; D001941:Breast Diseases / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D005260:Female; D006728:Hormones / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008408:Mastectomy; D011247:Pregnancy; D011248:Pregnancy Complications / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D012883:Skin Ulcer / Q000473:pathology / Q000601:surgery
D006728:Hormones