Ortho-hydroxybenzoates may act at the protein fraction to enhance membrane permeability.
Experimental observation suggests that the ability of ortho-hydroxybenzoates to alter the permeability of rat rectal epithelial membrane may involve an interaction between the ortho-isomer and the membrane protein. Such an interaction may cause a temporary structural modification of the protein rendering the membrane permeable to compounds normally poorly absorbed from the rectal compartment.
D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004847:Epithelial Cells; D007536:Isomerism; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012007:Rectum / Q000166:cytology; D012459:Salicylates / Q000494:pharmacology*
D008565:Membrane Proteins; D012459:Salicylates; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid