Characterization of 2-aminoisobutyric acid transport in Neurospora crassa: a general amino acid permease-specific substrate.
We report the characterization of an amino acid 2-aminoisobutyric acid was transported solely by the general amino acid permease and not by the neutral amino acid permease. Furthermore, this substrate was not metabolized after transport. The potential for a system-specific nonmetabolizable substrate as a tool in the analysis of amino acid transport and its regulation is discussed.
D026905:Amino Acid Transport Systems; D000621:Aminoisobutyric Acids / Q000378:metabolism*; D001693:Biological Transport, Active; D002956:Citrulline / Q000378:metabolism; D005656:Fungal Proteins / Q000096:biosynthesis; D007700:Kinetics; D026901:Membrane Transport Proteins / Q000378:metabolism*; D009154:Mutation; D009491:Neurospora / Q000378:metabolism*; D009492:Neurospora crassa / Q000235:genetics / Q000378:metabolism*; D013379:Substrate Specificity
D026905:Amino Acid Transport Systems; D000621:Aminoisobutyric Acids; D005656:Fungal Proteins; D026901:Membrane Transport Proteins; D002956:Citrulline