[New data about experimental Sipple syndrome in the rat].
Sipple syndrome, associating a C cells or parafollicular thyroid tumor and a pheochromocytoma of the medullary part of adrenal gland, can be experimentally induced with the use of an antithyroid drug, the thiamazole, in the rat. The treatment is applied here either between 3 and 11 months, or between 6 and 14 months of age. Tumors appear a long time after the treatment is stopped. Hypotheses are proposed to explain this phenomenon.
D000310:Adrenal Gland Neoplasms / Q000139:chemically induced / Q000473:pathology*; D000818:Animals; D008297:Male; D008713:Methimazole; D009374:Neoplasms, Experimental / Q000473:pathology; D010673:Pheochromocytoma / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D013577:Syndrome; D013964:Thyroid Neoplasms / Q000139:chemically induced / Q000473:pathology*
D008713:Methimazole
Nouvelles données sur le syndrome de Sipple expérimental chez le rat.