[Comparison of the antimitotic properties of cyclophosphamide and its biotransformation products on meristema plant cells and animal cells in in vitro culture].
N-mustard diamide phosphoric and above all 4-hydroperoxycyclophosphamide are clearly more cytotoxic than same kind, which is in accordance with the fact that these compounds are the active metabolites of cyclophosphamide. On the contrary, 4-ketocyclophosphamide and carboxyphosphamide, secondary metabolites inapt to be activated, are not more cytotoxic than cyclophosphamide. No tolerance does occur with these metabolites, contrary to cyclophosphamide itself.
D000818:Animals; D001711:Biotransformation; D002478:Cells, Cultured; D006224:Cricetinae; D003520:Cyclophosphamide / Q000378:metabolism / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects; D007668:Kidney / Q000166:cytology; D008938:Mitosis / Q000187:drug effects*; D059828:Plant Cells
D003520:Cyclophosphamide
Comparaison des propriétés antimitotiques du cyclophosphamide et de ses produits de biotransformation sur la cellule méristématique végétale et sur la cellule animale en culture in vitro.