Effects of acute administration of ethane hydroxydiphosphonate (EHDP) on skeletal scintigraphy with technetium-99m methylene diphosphonic acid (Tc-MDP) in the rat.
A study has been performed in the rat to assess the effect of EHDP on the distribution of 99Tcm-labelled MDP used for skeletal imaging. Profound alterations in bone, kidney and blood levels were observed. These observations cast doubt on the value of bone scans for monitoring the therapeutic effect of diphosphonates.
D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000378:metabolism; D004164:Diphosphonates / Q000097:blood / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D012968:Etidronic Acid / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium / Q000097:blood / Q000378:metabolism; D013669:Technetium Tc 99m Medronate
D004164:Diphosphonates; D013667:Technetium; D012968:Etidronic Acid; D013669:Technetium Tc 99m Medronate