The effect of testosterone on the half-life of ornithine decarboxylase-mRNA in mouse kidney.
The effect of testosterone on half-lives of ornithine decarboxylase and its mRNA in mouse kidney was studied. In addition to the prolongation of enzyme protein half-life by androgens, excess of testosterone increases in vivo the half-life of its mRNA to about 3-fold as manifested by the change of enzyme half-life in testosterone-treated animals after alpha-amanitin or actinomycin D. These results suggest that the accumulation of ornithine decarboxylase in mouse kidney by androgens is partly due to the stabilization of its mRNA.
D000818:Animals; D006207:Half-Life; D007668:Kidney / Q000187:drug effects / Q000201:enzymology*; D007700:Kinetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009955:Ornithine Decarboxylase / Q000235:genetics / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics*; D013739:Testosterone / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects
D012333:RNA, Messenger; D013739:Testosterone; D009955:Ornithine Decarboxylase