Two case reports of trazodone-induced mania.
Two unipolar depressed patients developed manic symptoms when treated with trazodone. The symptoms resolved when the drug was discontinued. The authors believe these to be the first two cases of such a reaction reported in the literature.
D000328:Adult; D001714:Bipolar Disorder / Q000139:chemically induced*; D003866:Depressive Disorder / Q000188:drug therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D010879:Piperazines / Q000009:adverse effects*; D011605:Psychoses, Substance-Induced / Q000209:etiology*; D014196:Trazodone / Q000009:adverse effects*
D010879:Piperazines; D014196:Trazodone