Severe cerebral depression after intoxication with tramadol in a 6-month-old infant.
Accidental intoxication with tramadol of a 6-month old infant was followed by severe cerebral depression. Studies on serum, cerebrospinal fluid, and urine drug levels indicated complete penetration of the blood-cerebrospinal fluid barrier by tramadol.
D001812:Blood-Brain Barrier; D001921:Brain / Q000187:drug effects*; D003511:Cyclohexanols / Q000506:poisoning*; D006801:Humans; D007223:Infant; D014147:Tramadol / Q000378:metabolism / Q000506:poisoning*
D003511:Cyclohexanols; D014147:Tramadol