Moxalactam kinetics in hemodialysis.
In eight patients with end-stage renal disease undergoing chronic hemodialysis moxalactam kinetics were examined. Volume of distribution (Vd), dialysance (Cd), and serum half-life (t1/2) were determined during dialysis with a 1.3 or 1.6 m2 dialyzer. The t1/2 was also determined during the interdialytic period. Vd was 0.25 +/- 0.04 l/kg and Cd was 32.6 +/- 11.7 ml/min and 67 +/- 25.5 ml/min with the 1.3 and 1.6 m2 dialyzers. The t1/2 was 4.8 +/- 0.9 hr using the 1.3 m2 dialyzer and 2.8 +/- 0.6 hr using the 1.6 m2 dialyzer. Moxalactam t1/2 during the interdialytic period was 23.4 +/- 9.6 hr.
D000328:Adult; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy; D002511:Cephalosporins / Q000097:blood*; D002513:Cephamycins / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009070:Moxalactam; D006435:Renal Dialysis
D002511:Cephalosporins; D002513:Cephamycins; D009070:Moxalactam