A comparison of skeletal uptakes of three diphosphonates by whole-body retention: concise communication.
Twenty normal volunteers had measurements of 24-hr whole-body retention (WBR) of three structurally related Tc-99m-labeled phosphonate skeletal imaging agents: (1-hydroxyethylidene) diphosphonate (HEDP), methylene diphosphonate (MDP), and hydroxymethylene diphosphonate (HMDP). The average WBR values, reflecting skeletal uptake, were 18.4, 30.3, and 36.6%, respectively. These results clearly illustrate that slight alterations in diphosphonate molecular structure have a significant effect upon specificity for osseous tissue, and thus may affect skeletal image quality and the usefulness of the WBR technique in diagnosing metabolic bone disease.
D000328:Adult; D000368:Aged; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism*; D004164:Diphosphonates / Q000378:metabolism*; D012968:Etidronic Acid / Q000378:metabolism*; D006801:Humans; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D013667:Technetium / Q000378:metabolism*; D013669:Technetium Tc 99m Medronate
D004164:Diphosphonates; D015609:Organotechnetium Compounds; C019561:technetium Tc 99m etidronate; D013667:Technetium; D012968:Etidronic Acid; D013669:Technetium Tc 99m Medronate