Chemical modification of spiramycins. II. Synthesis and antimicrobial activity of 4'-deoxy derivatives of neospiramycin I and their 12-(Z)-isomers.
4'-Deoxy derivatives of neospiramycin I and their 12-(Z)-isomers were synthesized by reductive dechlorination via 4'-epi-chloro derivatives. The 12-(Z)-derivatives were more active against bacteria in vitro than the corresponding 12-(E)-derivatives in spite of their low affinities to ribosomes.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D002851:Chromatography, High Pressure Liquid; D007536:Isomerism; D007933:Leucomycins / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015572:Spiramycin / Q000031:analogs & derivatives*
D000900:Anti-Bacterial Agents; D007933:Leucomycins; C039871:neospiramycin I; D015572:Spiramycin