Nephrotoxicity of contrast media assessed by occlusion arteriography.
The authors describe an experimental model for the study of nephrotoxicity induced by contrast media, based on a standardized injection combined with occlusion of the renal artery so as to expose the kidney to a high concentration of contrast medium for ten minutes. Iopamidol, ioxaglate, and both isosmolar and hyperosmolar saline were well tolerated, but diatrizoate caused marked radiological and pathological changes. This model may be helpful in studies of the mechanisms underlying contrast medium nephrotoxicity and evaluating differences in toxicity between contrast agents.
D000818:Animals; D002404:Catheterization; D003287:Contrast Media / Q000633:toxicity*; D003973:Diatrizoate / Q000633:toxicity; D003974:Diatrizoate Meglumine / Q000633:toxicity; D004285:Dogs; D004338:Drug Combinations / Q000633:toxicity; D007479:Iopamidol; D007483:Iothalamic Acid / Q000031:analogs & derivatives / Q000633:toxicity; D007485:Ioxaglic Acid; D007552:Isotonic Solutions; D007668:Kidney / Q000000981:diagnostic imaging / Q000187:drug effects*; D008297:Male; D011859:Radiography; D012077:Renal Artery / Q000000981:diagnostic imaging*; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging* / Q000209:etiology; D012462:Saline Solution, Hypertonic / Q000633:toxicity; D012965:Sodium Chloride / Q000633:toxicity; D013997:Time Factors; D014283:Triiodobenzoic Acids / Q000633:toxicity
D003287:Contrast Media; D004338:Drug Combinations; D007552:Isotonic Solutions; D012462:Saline Solution, Hypertonic; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; D007483:Iothalamic Acid; D003974:Diatrizoate Meglumine; D012965:Sodium Chloride; C027278:urovision; D007479:Iopamidol; D007485:Ioxaglic Acid