Is the rabbit ear model, in its present state, prophetic of acnegenicity?
The rabbit ear model has been proposed as a useful bioassay to establish the comedogenic and acnegenic qualities of chemical compounds and finished products, pharmaceutical and cosmetic, for topical application. This review highlights the many problems in performance of the test method, the absence of correlation with experience in the human, and, consequently, the serious limitations of the conclusions that can reasonably be drawn, especially for the clinical dermatologist.
D000152:Acne Vulgaris / Q000139:chemically induced*; D000328:Adult; D000818:Animals; D003358:Cosmetics / Q000494:pharmacology*; D004195:Disease Models, Animal; D004423:Ear / Q000187:drug effects*; D005260:Female; D006801:Humans; D007634:Keratitis / Q000139:chemically induced; D008899:Mineral Oil / Q000494:pharmacology; D009226:Myristates / Q000494:pharmacology; D010577:Petrolatum / Q000494:pharmacology; D014677:Pharmaceutical Vehicles; D011817:Rabbits; D012867:Skin / Q000187:drug effects; D013455:Sulfur / Q000494:pharmacology
D003358:Cosmetics; D009226:Myristates; D014677:Pharmaceutical Vehicles; C008205:isopropyl myristate; D013455:Sulfur; D010577:Petrolatum; D008899:Mineral Oil