Plasma concentration of platelet-specific proteins and fibrinopeptide A in patients with artificial heart valves.
beta-Thromboglobulin (beta TG), platelet factor 4 (PF4), fibrinopeptide A (FPA), lactic dehydrogenase (LDH), and platelet count were evaluated in patients with bioprostheses and prosthetic heart valves. beta TG and PF4 were significantly elevated in both patient groups (p less than 0.001), whereas FPA was normal. There was no significantly difference in plasma concentrations of beta TG and PF4 between patients with prosthetic heart valves and bioprostheses. LDH levels were significantly (p less than 0.001) higher and platelet count lower (p less than 0.001) in patients with prosthetic cardiac valves. The data indicate that bioprostheses do not cause haemolysis or activation of the coagulation system. The findings that the plasma concentration of platelet-specific proteins were elevated, support the assumption that both types of valves cause platelet damage.
D000328:Adult; D000818:Animals; D001705:Bioprosthesis; D001792:Blood Platelets; D001798:Blood Proteins; D005340:Fibrinogen; D005344:Fibrinopeptide A; D006350:Heart Valve Prosthesis; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008875:Middle Aged; D010976:Platelet Count; D010978:Platelet Factor 4; D013552:Swine; D001620:beta-Thromboglobulin
D001798:Blood Proteins; D001620:beta-Thromboglobulin; D005344:Fibrinopeptide A; D010978:Platelet Factor 4; D005340:Fibrinogen; D007770:L-Lactate Dehydrogenase