Effect of glucocorticoids on the composition of the aqueous humour of the rabbit eye.
Exogenous corticosteroids (dexamethasone, cortisol) inhibit the adrenal secretion of corticosterone in the rabbit and decrease the concentration of corticosterone in aqueous humour, increase glycaemia and cause a rise in glucose concentration in the aqueous. Except for a slight rise 16 h after the corticosteroid administration no effect on plasma or aqueous content of total protein was observed. This is in striking contrast with the increase of proteins in aqueous humour after ACTH injection. Thus it seems likely that corticosteroids do not mediate the effect of ACTH on the disruption of the blood-aqueous barrier.
D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects* / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D002199:Capillary Permeability / Q000187:drug effects; D003345:Corticosterone / Q000097:blood; D003907:Dexamethasone / Q000494:pharmacology*; D005260:Female; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000097:blood / Q000494:pharmacology; D007275:Injections, Intravenous; D011817:Rabbits
D001786:Blood Glucose; D001798:Blood Proteins; D003907:Dexamethasone; C007133:hydrocortisone hemisuccinate; D003345:Corticosterone; D006854:Hydrocortisone