[Comparative evaluation of the effectiveness of hepatoprotective agents in a liver lesion by combined ethanol and tuberculostatic agents].
Chronic experiments on male rats were carried out to study the hepatoprotective action of leganol, essentiale, tocopherol, pyridoxine, ATP and of a phospholipid complex containing phosphatidylserine, phosphatidylethanolamine and sphingomyelin under liver injury caused by combined ethanol, isoniazide and rifampicin. ATP, pyridoxine and tocopherol were not discovered to have the hepatoprotective action. Legalon, essentiale and the phospholipid complex exerted a marked hepatoprotective action, in the mechanism of which of importance are probably the reduced activity of membrane phospholipases and (for phospholipid drugs) substituting action.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury; D004353:Drug Evaluation, Preclinical; D000431:Ethanol / Q000633:toxicity*; D007538:Isoniazid / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008107:Liver Diseases / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D051381:Rats; D012293:Rifampin / Q000633:toxicity*; D013997:Time Factors
D000431:Ethanol; D007538:Isoniazid; D012293:Rifampin
Sravnitel'naia otsenka éffektivnosti nekotorykh gepatoprotektorov pri porazhenii pecheni sochetaniem étanola i tuberkulostaticheskikh sredstv.