The involvement of the catecholaminergic system in physostigmine-induced hyperactivity in rats.
Physostigmine-induced hyperactivity in rats was attenuated by reserpine 5 mg/kg) and haloperidol (0.025 mg/kg). Pretreatment with (bis-4-methyl-1-homopiperizinyl-his-carbonyl) disulphide (FLA-63) (2.5 mg/kg) resulted in physostigmine producing a biphasic effect on rats' locomotion while pretreatment with p-chloro-phenylalanine (pCPA) (300 mg/kg) did not significantly affect physostigmine-induced hyperactivity. The relevance of the catecholaminergic system in mediating physostigmine-induced hyperactivity is discussed.
D000818:Animals; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide / Q000494:pharmacology; D002395:Catecholamines / Q000502:physiology*; D010134:Fenclonine / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D010830:Physostigmine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D013997:Time Factors
D002395:Catecholamines; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; D012110:Reserpine; D010830:Physostigmine; D010134:Fenclonine