Brain lipid peroxidation induced by postischemic reoxygenation in vitro: effect of vitamin E.
The aerobic incubation of brain after a period of ischemia induced lipid peroxidation. The effect was greatest in vitamin E-deficient rats, intermediate in vitamin E-normal rats, and least in animals supplemented with vitamin E. In contrast, nitrogen incubation following ischemia produced a small effect only in the vitamin E-deficient animals. It appears that reoxygenation is required for lipid peroxides to accumulate in the brain. However, a trace of oxygen remaining during extreme ischemic hypoxia may be sufficient to cause slow propagation of free radical reactions when the vitamin E level is low.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D066298:In Vitro Techniques; D002546:Ischemic Attack, Transient / Q000097:blood / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D010101:Oxygen Consumption; D051381:Rats; D011919:Rats, Inbred Strains; D013858:Thiobarbiturates / Q000378:metabolism; D014810:Vitamin E / Q000097:blood / Q000494:pharmacology*; D014811:Vitamin E Deficiency / Q000378:metabolism
D008054:Lipid Peroxides; D013858:Thiobarbiturates; D014810:Vitamin E