The effect of ipratropium on exercise-induced bronchoconstriction.
We studied the effect of ipratropium on exercise-induced bronchoconstriction (EIB) at cold or warm temperatures. Although pulmonary function was better with ipratropium, its benefit was related to pre-exercise bronchodilation and not prevention of EIB. Ipratropium did not affect the augmented EIB in cold weather. Therefore, these phenomena are not primarily mediated via cholinergic mechanisms.
D000293:Adolescent; D000328:Adult; D000336:Aerosols; D001249:Asthma / Q000188:drug therapy*; D001250:Asthma, Exercise-Induced / Q000188:drug therapy*; D001286:Atropine Derivatives / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D009241:Ipratropium / Q000627:therapeutic use*; D008297:Male; D012129:Respiratory Function Tests; D013696:Temperature
D000336:Aerosols; D001286:Atropine Derivatives; D009241:Ipratropium