Effects of 3,5,3'-triiodothyronine on collagen synthesis by cultured human skin fibroblasts.
Addition of 3,5,3'-triiodothyronine (T3) (10(-9)-10(-7) M) to the media of cultured skin fibroblasts was shown to decrease the amount of newly synthesized soluble proteins, including collagen. Polyacrylamide gel electrophoresis of newly synthesized collagen demonstrated that addition of the hormone did not affect the processing of the molecule.
D000328:Adult; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D003094:Collagen / Q000096:biosynthesis*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D014176:Protein Biosynthesis; D012867:Skin / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D014284:Triiodothyronine / Q000494:pharmacology*
D014284:Triiodothyronine; D003094:Collagen