Steroid receptors in a group of Brazilian melanoma patients.
Melanoma biopsies from 22 Brazilian patients were evaluated for estrogen (ER), progesterone (PR) and glucocorticoid receptors (GR) by the dextran-coated charcoal method. Fifty percent (11/22) of the tumors exhibited specific estrogen and progesterone binding activities ranging from 5 to 25 fmol/mg protein for ER and from 18 to 200.75 fmol/mg protein for PR; 20/22 (90%) of the biopsies displayed significant quantities of GR, which ranged from 10.0 to 362.5 fmol/mg protein. The incidence and concentration of positive receptors in melanoma samples from Brazilian patients are similar to those of countries with populations of Caucasian origin.
D000328:Adult; D000368:Aged; D001665:Binding Sites; D001938:Brazil; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000032:analysis* / Q000473:pathology; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis; D011965:Receptors, Glucocorticoid / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D011987:Receptors, Steroid / Q000032:analysis*; D012878:Skin Neoplasms / Q000032:analysis* / Q000473:pathology; D014222:Triamcinolone Acetonide / Q000378:metabolism; D044465:White People
D011960:Receptors, Estrogen; D011965:Receptors, Glucocorticoid; D011980:Receptors, Progesterone; D011987:Receptors, Steroid; D014222:Triamcinolone Acetonide