Histamine hyperpolarizes hippocampal neurones in vitro.
The postsynaptic effect of histamine and impromidine, an H2-receptor agonist on CA1 pyramidal and dentate granule cells in the hippocampal slice of the rat is a hyperpolarization. Depolarizations are indirectly mediated. It is suggested that the hyperpolarization is generated by a conductance increase to potassium ions in the dendrites.
D000818:Animals; D004553:Electric Conductivity; D006146:Guanidines / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D006632:Histamine / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology; D017446:Impromidine; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011970:Receptors, Histamine H2 / Q000187:drug effects
D006146:Guanidines; D007093:Imidazoles; D011970:Receptors, Histamine H2; D006632:Histamine; D017446:Impromidine