Biochemical studies of membrane glycoproteins during red cell aging.
(1) There is a significant decrease of ATPase activities in red cell membranes with increasing age of the donor. (2) A comparison of blood groups A and O relates the higher ATPase activities of young donors to blood group A. (3) Membrane ATPase activities reveal an age-dependent decrease in young and old donors with blood group A. (4) There is an age-dependent decrease of the N-acetylneuraminic acid concentration of glycophorin. (5) The galactose content of glycophorin only increases in blood group A. (6) There are no age-dependent changes of the exposed galactose. (7) The experiments so far reveal an increase of IgG absorption to old glycophorin.
D000017:ABO Blood-Group System; D000251:Adenosine Triphosphatases / Q000097:blood; D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D002648:Child; D002675:Child, Preschool; D004905:Erythrocyte Aging; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006021:Glycophorins / Q000097:blood; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012794:Sialic Acids / Q000378:metabolism
D000017:ABO Blood-Group System; D006021:Glycophorins; D006023:Glycoproteins; D012794:Sialic Acids; D000251:Adenosine Triphosphatases