A purinergic component in the central actions of meprobamate.
The anxiolytic propanediol carbamate, meprobamate, potentiates the depressant actions of adenosine on the firing of rat cerebral cortical neurons. Meprobamate inhibits the uptake of adenosine by rat cortical synaptosomes at concentrations within the therapeutic range. Potentiation of endogenously released adenosine can account for many of the central actions of meprobamate.
D000200:Action Potentials / Q000187:drug effects; D000241:Adenosine / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects; D008297:Male; D008620:Meprobamate / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects; D011687:Purines / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D011687:Purines; D008620:Meprobamate; D000241:Adenosine