Ornithyl amphotericin methyl ester treatment of experimental candidiasis in rats.
After intravenous Candida albicans infection, rats received orinthyl amphotericin methyl ester, amphotericin B, or diluent intravenously. At doses of 0.1 and 0.5 mg/kg, the drugs were equally effective in preventing deaths. However, at doses of 2.0 mg/kg, mortality after treatment with amphotericin B was greater than that after placebo, whereas orinthyl amphotericin methyl ester was fully protective.
D000666:Amphotericin B / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains
D000935:Antifungal Agents; C017501:methylamphotericin B; D000666:Amphotericin B