Changes in muscle carnitine during regeneration.
Carnitine in rat skeletal muscle was measured before, during, and after muscle regeneration. Early regenerating tibialis anterior muscle consequent to bupivacaine injection was found to have smaller amounts of total, free, and acyl carnitine per milligram wet weight, but returned toward normal values as muscle regeneration was completed. Accumulation of DL-[3H]carnitine per milligram wet weight in regenerating muscle was less than one-half that of control muscle at day 4 (P less than 0.005), but was not significantly different from the control value at day 7. Our results are consistent with the hypothesis that the reported decrease in muscle carnitine content in several different human neuromuscular diseases is in part a manifestation of muscle fiber regeneration.
D000818:Animals; D002045:Bupivacaine / Q000494:pharmacology; D002331:Carnitine / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism* / Q000502:physiology; D009468:Neuromuscular Diseases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration; D013997:Time Factors
D002331:Carnitine; D002045:Bupivacaine