Lymphocyte proliferative response to allergen in timothy sensitive patients and healthy persons.
Presented are the results of the evaluation of lymphocytes proliferative response to a specific allergen in 30 pollinosis patients with hypersensitivity to timothy pollen, confirmed by the subject's allergy history, diagnostic skin tests, allergen-specific histamine release from basophils and by the presence of allergen-specific IgE-antibodies. The level of spontaneous proliferation of lymphocytes in pollinosis patients was found to increase. Manifestations of cell responses to Con A very similar in diseased and healthy subjects. The allergen-induced proliferative response of lymphocytes in pollinosis patients did not differ essentially from that in healthy persons. The authors make the supposition that the application of LBTR (using 3H-Thymidine incorporation) in demonstrating the immediate hypersensitivity to pollen allergens does not prove to be well grounded.
D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000276:immunology*; D003208:Concanavalin A / Q000494:pharmacology; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D007428:Intradermal Tests; D008213:Lymphocyte Activation; D037121:Plant Lectins; D006109:Poaceae / Q000276:immunology; D011058:Pollen / Q000276:immunology*; D011852:Radioallergosorbent Test; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology
D000485:Allergens; D037121:Plant Lectins; D003208:Concanavalin A; D007073:Immunoglobulin E