Changes of sulfated mucopolysaccharides and mucopolysaccharidases during fetal development.
The changes of sulfated mucopolysaccharides and mucopolysaccharidases during bovine fetal development were analyzed. It is shown that chondroitin sulfate C increases in concentration up to the 50th day of fetal development and then decreases progressively until its complete disappearance in most adult tissues. Likewise, hyaluronidase also reaches a peak on the 50th day and decreases in activity until its disappearance in adult tissues. On the other hand, heparitin sulfate and chondroitin sulfate B as well as beta-glucuronidase and beta-N-acetylglucosaminidase remain without significant changes during the whole period. The fetal chondroitin sulfate C is tissue specific with different molecular weights depending on the tissue of origin. Some properties of fetal muscle and brain hyaluronidase are also described. The possible role of chondroitin sulfate C and hyaluronidase in the processes of differentiation and division is discussed in view of the present findings.
D000118:Acetylglucosaminidase / Q000378:metabolism; D000818:Animals; D002417:Cattle; D002809:Chondroitin Sulfates / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000502:physiology*; D005865:Gestational Age; D005966:Glucuronidase / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000378:metabolism*; D006821:Hyaluronoglucosaminidase / Q000378:metabolism; D008190:Lyases / Q000378:metabolism*; D008970:Molecular Weight; D009928:Organ Specificity; D011247:Pregnancy
D006025:Glycosaminoglycans; D002809:Chondroitin Sulfates; C021812:mucopolysaccharidase; D005966:Glucuronidase; D006821:Hyaluronoglucosaminidase; D000118:Acetylglucosaminidase; D008190:Lyases