[Pharmacokinetic studies of ampicillin during and following intravenous drip infusion in healthy human volunteers].
The pharmacokinetics of ampicillin (ABPC) during and following intravenous drip infusion in 3 healthy volunteers weighing 63.0 kg to 75.0 kg. ABPC was administered 1.0 g by intravenous drip infusion for 1 hour. Serum concentrations were measured, and simulation curve were obtained by using one-compartment model and two-compartment model. The simulation curve by two-compartment model was more applicable than the simulation curve by one-compartment model. Most appropriate administration rate of intravenous drip infusion was discussed due to calculated serum levels, therapeutic AUC and effective time.
D000328:Adult; D000667:Ampicillin / Q000008:administration & dosage / Q000097:blood* / Q000652:urine; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics; D008297:Male; D008954:Models, Biological
D000667:Ampicillin