[Changes in ATPase activity and nonesterified fatty acid concentration in heart and liver mitochondria in experimental mitral valve insufficiency].
Total content of unesterified fatty acids and activity of ATPases/latent, stimulated by Mg2+, 2,4-DNP, Mg2+ and 2,4-DNP/were studied in heart and liver mitochondria of rabbits with decompensated mitral valvular disease. The activities of Mg2+, DNP-, Mg2+ and DNP-stimulated ATPases were decreased in heart mitochondria. At the same time, content of unesterified fatty acids was increased. Content of the fatty acids was decreased in liver mitochondria and activity of ATPase was unaltered. Possible mechanisms of the alterations observed are discussed.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D004140:Dinitrophenols / Q000494:pharmacology; D004789:Enzyme Activation; D005230:Fatty Acids, Nonesterified / Q000032:analysis*; D006333:Heart Failure / Q000209:etiology / Q000378:metabolism; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism*; D008930:Mitochondria, Liver / Q000378:metabolism*; D008944:Mitral Valve Insufficiency / Q000150:complications / Q000201:enzymology / Q000378:metabolism*; D011817:Rabbits
D004140:Dinitrophenols; D005230:Fatty Acids, Nonesterified; D000251:Adenosine Triphosphatases; D008274:Magnesium
Izmenenie aktivnosti ATF-azy i soderzhanie neésterifitsirovannykh zhirnykh kislot v mitokhondriiakh serdtsa i pecheni pri éksperimental'noĭ nedostatochnosti mitral'nogo klapana.