T-cell functions in nude mice: proliferation of spleen cells from athymic mice in the one-way xenogeneic mixed leucocyte reaction.
Spleen cells from nude mice proliferate in vitro when stimulated with xenogeneic (human) lymphoid cells rendered unresponsive by addition of digitalis glycosides. In digitalis-sensitive species, such as humans, DNA, RNA, carbohydrate, and protein synthesis is completely blocked by addition of low concentrations of glycoside, whereas no impairment is found in digitalis-resistant species such as mouse. Since T cells have been implicated to be the cells responding in the mixed leucocyte reaction, this finding may suggest the occasional existence of "T-like" cells in the spleens of nude mice.
D000818:Animals; D002478:Cells, Cultured; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008819:Mice, Nude / Q000502:physiology*; D008937:Mitomycins / Q000494:pharmacology; D010042:Ouabain / Q000494:pharmacology; D013154:Spleen / Q000166:cytology*; D013601:T-Lymphocytes / Q000276:immunology*; D014965:X-Rays
D006680:HLA Antigens; D008937:Mitomycins; D010042:Ouabain