Fc receptors on human T lymphocytes: loss of Fc mu and expression of Fc gamma receptors by T cells stimulated in mixed lymphocyte reaction.
The consequences of allogeneic stimulation on the expression of Fc mu or Fc gamma receptors were analysed in T-cell populations responding in mixed lymphocyte reaction (MLR). Unfractionated T-cell populations were cultured with a pool or irradiated allogeneic T-depleted cells. The responder E-rosetting cells progressively lost Fc mu and acquired Fc gamma receptors. The change of the original Fc receptor phenotype is not the consequence of a preferential proliferative response of TG versus TM cells but is likely due to a de novo expression of Fc gamma receptors by T cells lacking detectable Fc receptors (T-null) and also to the loss of Fc mu and expression of Fc gamma receptors by TM cells. These data suggest that, after MLR, responder T cells can modify their Fc receptor phenotype.
D000818:Animals; D002417:Cattle; D006801:Humans; D007958:Leukocyte Count; D007959:Lymphocyte Culture Test, Mixed; D008215:Lymphocytes, Null / Q000276:immunology; D011961:Receptors, Fc; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
D011961:Receptors, Fc