[Clinical significance of the short-term incubation test for the therapy of metastatic breast cancer].
Between January 1978 and October 1980 97 tissue samples of histologically verified carcinoma of the breast were received for performance of the short-term incubation test. 25 tumour samples could not be prepared as cell suspension sufficient for testing. Among the 72 performed tests there were 9 with stimulation of 3H-uridine uptake by doxorubicin. Thus only 63 tests could be evaluated. Results were correlated with clinical data of the patients. No significant correlations could be established between tumour stage at time of diagnosis, age, menopausal state, receptor state, and the test result. There was also no differentiation between favourable and unfavourable prognoses as regards free interval and rate of survival. A correlation between results of tests and success or failure of cytostatic treatment could not be ascertained.
D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D003114:Colony-Forming Units Assay / Q000379:methods*; D004317:Doxorubicin / Q000494:pharmacology; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008593:Menopause; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D013997:Time Factors; D014410:Tumor Stem Cell Assay / Q000379:methods*; D014529:Uridine / Q000037:antagonists & inhibitors
D004317:Doxorubicin; D014529:Uridine
Klinische Bedeutung des Kurzzeitinkubationstests für die Therapie des metastasierten Mammakarzinoms.