The effect of lysosome factors derived from PMNL of multiple sclerosis and systemic lupus erythematosus patients on suppressor cell activity in vitro.
The lysosomal factors obtained from PMNL of healthy persons and patients with multiple sclerosis, systemic lupus erythematosus and other neurological diseases inhibited in vitro the generation of Con A-induced suppressor cell activity. The results obtained proved that these factors from granulocytes of MS-relapse and active LE have a stronger inhibitory effect on suppressor cell activity than on healthy ones.
D000328:Adult; D000368:Aged; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D008134:Long-Term Care; D008180:Lupus Erythematosus, Systemic / Q000097:blood* / Q000276:immunology; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood* / Q000276:immunology; D009422:Nervous System Diseases / Q000097:blood / Q000276:immunology; D009504:Neutrophils / Q000378:metabolism*; D011506:Proteins / Q000494:pharmacology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects
D011506:Proteins; C018589:lysosomal proteins; D003208:Concanavalin A