Correlation between the activity of hepatic benzo (a) pyrene hydroxylase in human needle biopsies and the clearance of glymidine.
The activity of benzo (a) pyrene hydroxylase was estimated in liver biopsy material obtained by needle biopsy. The activity of the enzyme was lowest in patients with moderate to severe hepatitis or chronic active hepatitis, and highest in patients treated for tuberculosis with the tuberculostatic agents rifampicin, INH and ethambutol. A significant correlation was found between the activity of the benzo (a) pyrene hydroxylase in the biopsy specimens and the plasma clearance of the antidiabetic agent glymidine.
D000328:Adult; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D001579:Benzopyrene Hydroxylase / Q000378:metabolism*; D001580:Benzopyrenes; D001711:Biotransformation; D005260:Female; D006207:Half-Life; D006801:Humans; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008107:Liver Diseases / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D013449:Sulfonamides / Q000378:metabolism*; D014376:Tuberculosis / Q000378:metabolism
D001580:Benzopyrenes; D013449:Sulfonamides; D001579:Benzopyrene Hydroxylase; D001189:Aryl Hydrocarbon Hydroxylases