[Tissue-specific regulation of rat liver mitochondrial oxidative phosphorylation by a soluble phase of cells from that organ].
Tissue specificity of mitochondrial respiration stimulation under the effect of a soluble phase of liver cells (SPC) is preserved by addition to dinitrophenol but is reserved in the presence of oligomycin. Addition of rotenon in the presence of SPC entails a tissue-specific increase in respiration that is proportional to the respective increase in respiration of intact mitochondria in the presence of the inhibitor mentioned. SPC tissue-specifically inhibits ATPase activity of liver mitochondria. This fraction of SPC is capable of recovering the coupling of oxidative phosphorylation of mitochondria whose respiration is inhibited by adding ADP. A conclusion is made that SPC is capable not only to decrease tissue-specifically the coupling of intact mitochondria but also to raise it in mitochondria with deranged oxidative phosphorylation. This assures intratissue organization of liver metabolism by means of tissue-specific stabilization of liver cell energy metabolism.
D019297:2,4-Dinitrophenol; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D004140:Dinitrophenols / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism; D008110:Liver Extracts / Q000494:pharmacology*; D008930:Mitochondria, Liver / Q000378:metabolism*; D009840:Oligomycins / Q000494:pharmacology; D009928:Organ Specificity; D010085:Oxidative Phosphorylation; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D012402:Rotenone / Q000494:pharmacology
D004140:Dinitrophenols; D008110:Liver Extracts; D009840:Oligomycins; D012402:Rotenone; D000251:Adenosine Triphosphatases; D019297:2,4-Dinitrophenol; D011188:Potassium
Tkanespetsificheskoe regulirovanie okislitel'nogo fosforilirovaniia mitokhondriĭ pecheni krysy rastvorimoĭ fazoĭ kletok étogo organa.