Estimation of HLA phenotype frequencies from two- and three-locus haplotype frequencies.
A procedure for estimating HLA phenotype frequencies from two- and three-locus haplotype frequencies is described. Formulae for this procedure are derived, and examples are presented to illustrate the application. The procedure is useful when multiple-locus phenotype frequencies from a laboratory control series are not available, or when a sufficiently large number of laboratory controls have not yet been typed for recently defined antigens or loci to yield stable multiple-locus rates for comparative purposes.
D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics; D010641:Phenotype; D044465:White People
D006680:HLA Antigens