[Enhanced immunogenicity of xenogenized tumor cells in rats pretreated with cyclophosphamide (author's transl)].
Immunization with xenogenized tumor cells, tumor cells infected with murine leukemia viruses produced strong antitumor immunity. In this study, the immunogenicity of xenogenized tumor cells was compared in cyclophophamide-treated and nontreated rats. CY treatment 3 days before immunization with xenogenized tumor cells enhanced antitumor cell-mediated immunity and antibody responses. However, CY treatment after immunization had no effect. Transfer of thymus cells from normal rats before the tumor challenge abolished the CY-induced augmenting effect. From these results, it is suggested that the elimination of precursors of suppressor T-cells results in enhanced immunogenicity of xenogenized tumor cells.
D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000494:pharmacology*; D005622:Friend murine leukemia virus; D007111:Immunity, Cellular / Q000187:drug effects*; D007942:Leukemia, Experimental / Q000276:immunology*; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014183:Transplantation, Heterologous
D000276:Adjuvants, Immunologic; D003520:Cyclophosphamide