Kawasaki disease complicated with mitral insufficiency. Autopsy findings with special reference to valvular lesion.
A case of mucocutaneous lymph node syndrome (Kawasaki disease, MCLS) complicated with mitral insufficiency is reported. This patient showed severe valvulitis, which was thought to be the main cause of mitral regurgitation. Two other patients with MCLS who did not present clinical signs of mitral insufficiency revealed the presence of mild valvulitis. The morphological alterations of cardiac valves were non-specific and mainly consisted of inflammatory infiltration, increment of fibrous connective tissue, and proliferation of small capillaries. In addition to the coronary aneurysms, the involvement of cardiac valves should receive attention as the sequelae of MCLS.
D000783:Aneurysm / Q000209:etiology; D001021:Aortic Valve / Q000473:pathology; D003331:Coronary Vessels; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008943:Mitral Valve / Q000473:pathology*; D008944:Mitral Valve Insufficiency / Q000209:etiology / Q000473:pathology*; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications / Q000473:pathology*