Dopamine receptors in the anterior lobe of the human pituitary gland: autoradiographic localization.
We examined the distribution of dopamine and serotonin receptors in human pituitary gland by light microscopic autoradiography using [3H]spiperone as a binding ligand. Clusters of specific binding sites for [3H]spiperone were observed in the anterior pituitary. This clustering is similar to the clustering of lactotrophs observed in immunohistochemical studies. No specific binding sites for [3H]spiperone were present in the posterior lobe of the pituitary gland. We found no evidence for the presence of serotonin-2 receptors (i.e. cinanserin-displaceable [3H]spiperone binding) in human pituitary.
D001345:Autoradiography; D006801:Humans; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D010904:Pituitary Gland, Posterior / Q000378:metabolism; D011954:Receptors, Dopamine / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000378:metabolism; D013134:Spiperone / Q000378:metabolism
D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D013134:Spiperone