Determination of zinc, copper, manganese, and iron in blood from patients with light-sensitive skin diseases.
It is known that some trace elements have an influence on the repair of UV light induced DNA damage. We have detected certain alterations in the excision repair of patients with photodermatoses. In these investigations of screening character the levels of zinc, copper, manganese, and iron were measured by means of atomic absorption spectrophotometry in the whole blood of 31 patients with polymorphic light eruption and 27 patients with cutaneous porphyrias. In active stage of polymorphic light eruption decreased zinc, copper, and iron concentrations and an increased manganese content were found. In remission only the zinc level was lower. In the active stage of cutaneous porphyrias a decreased zinc and iron content as well as an increased manganese level could be detected. A presumable connection between the findings and the rate of the excision repair is discussed.
D003300:Copper / Q000097:blood*; D004247:DNA / Q000528:radiation effects; D004260:DNA Repair; D006801:Humans; D007501:Iron / Q000097:blood*; D008345:Manganese / Q000097:blood*; D010787:Photosensitivity Disorders / Q000097:blood*; D011164:Porphyrias / Q000097:blood*; D012871:Skin Diseases / Q000097:blood*; D015032:Zinc / Q000097:blood*
D008345:Manganese; D003300:Copper; D004247:DNA; D007501:Iron; D015032:Zinc