Light dependent accumulation of macrophages at the photoreceptor-pigment epithelial interface in the retina of albino mice.
In the subretinal space of albino mice, macrophages appear from the time of eye opening and increase in number for 6 months; thereafter they decline with age. Dark rearing retards the accumulation of these cells, and exposure to constant light results in a rapid increase. Observations suggest that macrophages appear as a response to visual cell decay in albino mice and supplement the phagocytic activity of the pigment epithelium.
D000375:Aging; D000818:Animals; D003624:Darkness; D004847:Epithelial Cells; D008027:Light; D008264:Macrophages / Q000502:physiology* / Q000528:radiation effects; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D010786:Photoreceptor Cells / Q000166:cytology*; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000166:cytology*; D012168:Retinal Pigments / Q000378:metabolism*
D012168:Retinal Pigments