Spontaneous malformations in JW-NIBS rabbits.
The frequency of spontaneous anomalies among JW-NIBS rabbits in our laboratory is reported. The study was based on 1217 live fetuses obtained from 185 of an origin sample of 195 pregnant females; the remaining 10 (5.1%) aborted. Seven (0.57%) of the fetuses had the following external anomalies: multiple anomalies with craniofacial anomalies and thoraco-, gastroschisis (3 cases), microcephaly with open eyelids and microstomia (1), microphthalmia (1), anury (1) and brachyury (1). Among 1213 fetuses, 2 (0.16%) had abdominal visceral anomalies: agenesis of gall bladder and hypoplasia of the ovary were each found in one animal. Head and thoracic visceral anomalies were found in 6 (1.73%) of 347 fetuses, and skeletal anomalies in 6 (0.69%) of 867 fetuses. 4.03% of fetuses had 13 ribs.
D000015:Abnormalities, Multiple / Q000453:epidemiology / Q000662:veterinary*; D000818:Animals; D000830:Animals, Laboratory; D001842:Bone and Bones / Q000002:abnormalities; D004065:Digestive System Abnormalities; D005260:Female; D011247:Pregnancy; D011817:Rabbits; D012886:Skull / Q000002:abnormalities; D013623:Tail / Q000002:abnormalities