Vasopressin and the kindling of seizures.
In an attempt to confirm a previous report that two intracerebroventricular injections of arginine-vasopressin (AVP) can kindle convulsive seizures, we injected AVP up to 14 times. Although behavioral and electrographic effects were observed, seizures failed to develop with any reliability. These results call into question the phenomenon of AVP kindling.
D000818:Animals; D001127:Arginine Vasopressin / Q000008:administration & dosage / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects; D004569:Electroencephalography; D007276:Injections, Intraventricular; D007696:Kindling, Neurologic / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats
D001127:Arginine Vasopressin