Bronchodilator effects of clemastine, ipratropium, bromide, and salbutamol in preschool children with asthma.
The bronchodilator activity in nebulised salbutamol, ipratropium bromide, clemastine, and a placebo was studied in 14 asthmatic children aged between 3 and 5 years. Changes in lung function were monitored by measuring peak expiratory flow rate and total respiratory resistance using a modification of the forced oscillation technique. Ipratropium bromide produced a degree of bronchodilation similar to that of salbutamol, but the bronchodilatory activity of clemastine was not appreciably better than for the placebo.
D000403:Airway Resistance / Q000187:drug effects; D000420:Albuterol / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy*; D001286:Atropine Derivatives / Q000627:therapeutic use*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D002675:Child, Preschool; D002974:Clemastine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D009241:Ipratropium / Q000627:therapeutic use*; D008297:Male; D010366:Peak Expiratory Flow Rate; D011759:Pyrrolidines / Q000627:therapeutic use*
D001286:Atropine Derivatives; D001993:Bronchodilator Agents; D011759:Pyrrolidines; D002974:Clemastine; D009241:Ipratropium; D000420:Albuterol