Combination bronchodilator therapy in asthma.
This study has compared the short-term bronchodilator effects of inhaled anticholinergic (ipratropium bromide) and sympathomimetic (fenoterol) agents alone and in combination in 18 asthmatic patients. the study was of double-blind, placebo-controlled, crossover design. The combination of 60 micrograms ipratropium bromide and 200 micrograms of fenoterol had a greater bronchodilator effect than lower dose combinations or either drug alone. Small but significant gains may be made with combination inhaled bronchodilator therapy.
D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy*; D001286:Atropine Derivatives / Q000627:therapeutic use*; D001993:Bronchodilator Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D005280:Fenoterol / Q000009:adverse effects / Q000627:therapeutic use*; D005541:Forced Expiratory Volume; D006801:Humans; D009241:Ipratropium / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008450:Maximal Midexpiratory Flow Rate; D008875:Middle Aged; D010276:Parasympatholytics / Q000627:therapeutic use; D013566:Sympathomimetics / Q000627:therapeutic use; D014797:Vital Capacity
D001286:Atropine Derivatives; D001993:Bronchodilator Agents; D004983:Ethanolamines; D010276:Parasympatholytics; D013566:Sympathomimetics; D005280:Fenoterol; D009241:Ipratropium