Cytopathology of an unusual case of centronuclear myopathy. Light- and electron-microscopic investigations.
The results of enzyme-histochemical and electron-microscopic investigations of a patient with centronuclear myopathy combined with targets, cores and prevalence of type-I fibers are presented. The patient had suffered from perinatal hypoxic brain damage, causing enlargement of the ventricular system, slight frontal atrophy and right-sided hemiparesis. Morphologic investigation of muscle fibers demonstrated dynamic activity of an autophagic system represented by a distinct increase of Golgi components adhering to the nuclear surface. By analysing the lytic events ad their sequences, a postnatal secondary migration of subsarcolemmal nuclei to the central regions of muscle fibers can be postulated.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000293:Adolescent; D002467:Cell Nucleus / Q000648:ultrastructure; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D008854:Microscopy, Electron; D009132:Muscles / Q000201:enzymology / Q000473:pathology*; D009135:Muscular Diseases / Q000201:enzymology / Q000473:pathology*; D009210:Myofibrils / Q000648:ultrastructure; D009246:NADH Tetrazolium Reductase / Q000378:metabolism
D009246:NADH Tetrazolium Reductase; D000251:Adenosine Triphosphatases