An examination of possible interactions between zimelidine, a serotonin uptake inhibitor, and ethanol ingested conjointly in human subjects.
Non-alcoholic male subjects were given either a placebo or zimelidine (100, 200 or 300 mg, p.o.) 2 h prior to consumption of alcohol (1 g/kg) or a non-alcoholic mixer. Slight increases in heart rate and diastolic blood pressure induced by alcohol were unaffected by pretreatment with zimelidine. Alcohol, zimelidine, and the combination of the two, did not affect any of the hematologic measures except for serum potassium levels. The latter were reduced slightly but not in any discernible pattern. Blood alcohol concentrations were not changed by zimelidine pretreatment. Conversely, blood concentrations of zimelidine and its metabolite norzimelidine were also relatively unaffected by alcohol consumption. In general, the results indicate that the simultaneous administration of zimelidine and alcohol to human subjects does not produce any observable adverse effects.
D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking; D001794:Blood Pressure / Q000187:drug effects; D001977:Brompheniramine / Q000009:adverse effects* / Q000031:analogs & derivatives / Q000097:blood; D004347:Drug Interactions; D004573:Electrolytes / Q000097:blood; D000431:Ethanol / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000187:drug effects; D011725:Pyridines / Q000009:adverse effects*; D011930:Reaction Time / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists / Q000009:adverse effects*; D015031:Zimeldine
D004573:Electrolytes; D011725:Pyridines; D012702:Serotonin Antagonists; D012701:Serotonin; D015031:Zimeldine; D000431:Ethanol; D001977:Brompheniramine