[Behavior of blood amino acids after acute administration of glucagon in humans].
The authors have studied the behavior of Aminoacids (AA), GH, Prolactin (PRL), Insulin (IRI) and blood sugar (BS) after fast intravenous injection of 1 mg of Glucagon (G), in eight normal volunteers. The rise in BS levels soon after G. administration at time 10', 20', 30', 45', 60' prompted to consider the initial phase of the experimental to be under G predominance, although IRI did respond to the infusion with a sharp rise, at time 10', 20', 30', 45'. Glycine, serine, threonine, alanine, lysine, phenylalanine and arginine displayed a significant reduction already at time 10' or 20', when G metabolic effects were dominant, a selective G influence on these AA can be supposed. At time 45' and 60' tyrosine, histidine, methionine, valine, leucine, isoleucine, proline, decreased significantly and glycine, serine, threonine, lysine, alanine, phenylalanine, evidenced further reduction. GH and PRL were not affected by the administration of G.
D000328:Adult; D000596:Amino Acids / Q000097:blood*; D005934:Glucagon / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged
D000596:Amino Acids; D005934:Glucagon
Comportamento degli aminoacidi plasmatici dopo somministrazione acuta di glucagone nell'uomo.