Once a day theophylline; serum concentrations.
Twenty four hour profiles of serum theophylline concentrations were examined in 15 asthmatic children taking a new theophylline preparation once a day. Peak concentrations occurred at a time when nocturnal wheezing is likely. Fluctuation in concentrations throughout the day was greater than with other currently available preparations, but the importance of this has yet to be determined.
D000293:Adolescent; D001249:Asthma / Q000097:blood* / Q000188:drug therapy; D002648:Child; D003692:Delayed-Action Preparations; D006801:Humans; D013806:Theophylline / Q000008:administration & dosage / Q000097:blood*; D013997:Time Factors
D003692:Delayed-Action Preparations; D013806:Theophylline