[Problems concerned with microbial mutagenicity tests].
Mutagenicity tests using microorganisms are the Salmonella-typhimurium test (Ames), the test with a polymerase A deficient Escherichia coli, the Saccharomyces cerevisiae D3 system and the Neurospora crassa test. Differences in results of Ames-test may be due to differences preserving the tester strains, the choice of solvent and the dosage of the test compounds, last not least is the production of S-9. The polymerase A deficient Escherichia coli system seems easier to handle than the Saccharomyces cerevisiae- or Neurospora crassa-test. The metabolic activation with different forms of S-9 is needed in the Salmonella- and the Escherichia coli-system. Nevertheless it is not possible to decide if a substance is carcinogenic for human beings or animals with microbial mutagenicity tests only.
D002273:Carcinogens / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D009492:Neurospora crassa / Q000187:drug effects; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects
D002273:Carcinogens; D009153:Mutagens
Zur Problematik der mikrobiellen Mutagenitätstests.