Induction of mammary tumors with metronidazole in female Sprague-Dawley rats.
Sprague-Dawley rats were administered low doses of metronidazole similar to those used in humans, and then subjected to a long-term follow-up. Metronidazole caused a significant rise in mammary tumors in the female rats (p less than 0.001) after a mean latency period of 100.5 weeks.
D000230:Adenocarcinoma / Q000139:chemically induced; D000232:Adenofibroma / Q000139:chemically induced; D000818:Animals; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D008795:Metronidazole; D051381:Rats; D013997:Time Factors
D008795:Metronidazole