Effect of a single maximal and low multiple doses of testosterone propionate (TP) on male reproductive organs in Long Evans rats.
Testosterone as a male contraceptive agent was tried on two age groups of rats of Long-Evans strain and with two dosage schedule. A general increase in accessory organs weights like seminal vesicle and ventral prostate was observed in all groups of animals with all dosage schedule. The testicular weight was reduced particularly in low multiple dosage group. Gross atrophy with marked irregularity in germ cell pattern and population, suppression of spermatogenesis and atrophy of Leydig cells in the testis of low multiple dosage group were evident without affecting the potentiality to sex drive. A further study is suggested to examine the time period needed for testicular recovery and return of normal spermatogenesis before its possible trial on male volunteers in Bangladesh.
D000818:Animals; D001284:Atrophy / Q000139:chemically induced; D003272:Contraceptive Agents, Male / Q000494:pharmacology*; D008297:Male; D009929:Organ Size; D011467:Prostate / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects* / Q000473:pathology; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000473:pathology; D013739:Testosterone / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D003272:Contraceptive Agents, Male; D013739:Testosterone