[Severe neurological toxicity (coma, convulsions, distal motor neuropathy) secondary to the association of accidental poisoning by isoniazid and a protocol containing high doses of vincristine].
Authors report the case of a 19 year old metastatic Ewing's sarcoma, prophylactically treated for suspected tuberculosis by Rifampicin and INH. Hepatic failure was induced by accidental overdose of INH. A high dose containing VCR protocol associated, lead to a coma with convulsions and severe motor peripheral neuropathy partially regressive. Neurological incidents of VCR, INH and their association are reviewed.
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001927:Brain Diseases / Q000139:chemically induced*; D006501:Hepatic Encephalopathy / Q000139:chemically induced; D006801:Humans; D007538:Isoniazid / Q000506:poisoning*; D008297:Male; D012512:Sarcoma, Ewing / Q000188:drug therapy; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy; D014750:Vincristine / Q000009:adverse effects*
D014750:Vincristine; D007538:Isoniazid
Toxicité neurologique sévère (coma, convulsions, neuropathie motrice distale) secondaire à l'association d'une intoxication accidentelle à l'isoniazide (INH) et d'un protocole comportant de fortes doses de vincristine (VCR).