[Therapy of gonarthrosis using chondroprotective substances. Prospective comparative study of glucosamine sulphate and glycosaminoglycan polysulphate].
68 patients with mild or moderate gonarthritis were treated with intra-articular injections of glucosamine sulphate or glycosaminoglycan polysulphate over a period of six weeks. The therapy was successful in two thirds of these patients. "Loading" pain was eliminated or improved in about 80%, "getting-going" pain in about 64%, and signs of synovialitis in about 66%. Gait function and mobility were improved. Glucosamine had a superior effect, in particular in mild arthritis, achieving an improvement of pain in 90%, while glycosaminoglycan polysulphate was successful in advanced cases. The tolerance of the two substances was 94%. The results and the underlying modes of action of the substances are discussed.
D001168:Arthritis / Q000188:drug therapy*; D002358:Cartilage, Articular / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006025:Glycosaminoglycans / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011509:Proteoglycans / Q000096:biosynthesis
D006025:Glycosaminoglycans; D011509:Proteoglycans; C013786:A73025
Die Therapie der Gonarthrose mit chondroprotektiven Substanzen. Prospektive Vergleichsstudie zwischen Glukosaminsulfat und Glykosaminoglykanpolysulfat.