Metabolic implications in the elevation of serum activity of intestinal alkaline phosphatase in chronic renal failure.
The activity of intestinal isoenzyme of serum alkaline phosphatase was evaluated in 21 non-dialyzed patients with advanced renal failure and in 52 patients on regular hemodialysis. In patients without hepatopathy, a significant inverse correlation was found between the enzyme activity and serum calcium levels. Hepatopathy was the most significant variable influencing the enzyme activity in patients on dialysis. Secondary hyperparathyroidism and a decreased rate in enzyme elimination should be assessed for the above-normal activities of intestinal ALP in serum in chronic renal failure.
D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood*; D002118:Calcium / Q000097:blood; D006801:Humans; D007422:Intestines / Q000201:enzymology*; D007527:Isoenzymes / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000150:complications / Q000201:enzymology*; D008107:Liver Diseases / Q000201:enzymology / Q000209:etiology; D010281:Parathyroid Hormone / Q000097:blood
D007527:Isoenzymes; D010281:Parathyroid Hormone; D000469:Alkaline Phosphatase; D002118:Calcium