Genetics of a non-H-2 antigen that stimulates "unrestricted" helper T cells and MLR.
The inheritance of antigens expressed by C3H/Tif B cells that stimulate MHC-unrestricted helper T cells from C3H/HeJ was investigated. F1 hybrids between C3H/HeJ and C3H/Tif and 39 C3H/HeJ X F1 backcross mice were characterized as to the ability of their spleen cells to stimulate a proliferative C3H/HeJ T helper cell response and to respond to helper cell activity by the development of polyclonal plaque-forming cell responses. Backcross progeny wee also typed for the following markers segregating in this cross: 1) Responsiveness to the B cell mitogen lipopolysaccharide (LPS); 2) LyM-1 allotype; 3) antigen(s) stimulating a primary non-H-2 MLR between these strains, previously ascribed to Mls locus differences, 4) expression of target antigens for cytotoxic T cells raised in the same strain combination. The antigen(s) recognized by helper cells and those stimulating primary MLR are controlled by autosomal gene(s) and segregate as a single trait. These antigens, however, are not encoded in genes linked to either the Lps or the Mls loci, and are not recognized by cytotoxic T cells raised in the same strain combination.
D000818:Animals; D000941:Antigens / Q000235:genetics; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D003602:Cytotoxicity, Immunologic; D008040:Genetic Linkage; D005819:Genetic Markers; D006183:H-2 Antigens / Q000235:genetics*; D007959:Lymphocyte Culture Test, Mixed; D008540:Meiosis; D051379:Mice; D008809:Mice, Inbred C3H / Q000235:genetics*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
D000941:Antigens; D005819:Genetic Markers; D006183:H-2 Antigens