[Diffuse melanosis with generalized and ocular metastasis in malignant melanoma].
In a 48-year-old female patient 9 months after excision of a nodular melanoma on the back, multiple cutaneous, subcutaneous and lymph node metastases developed. Thereafter diffuse melanosis developed together with ocular metastatic involvement during immunochemotherapy with BCG and dacarbazine (DTIC). Most of the cutaneous metastases disappeared spontaneously with halo formation, while new nodes formed. The patient survived with disseminated melanoma more than 2 1/2 years without cytostatic therapy, before she died from intestinal metastases.
D003131:Combined Modality Therapy; D005123:Eye / Q000473:pathology; D005134:Eye Neoplasms / Q000473:pathology / Q000556:secondary*; D005260:Female; D006801:Humans; D008545:Melanoma / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D008548:Melanosis / Q000473:pathology*; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology / Q000556:secondary* / Q000628:therapy
Diffuse Melanose mit generalisierter und okulärer Metastasierung bei malignem Melanom.