Thymidine incorporation in the olfactory epithelium of mice: early exponential response induced by olfactory neurectomy.
The incorporation of [3]thymidine by the olfactory epithelium rises exponentially immediately after nerve section, reaches a peak 12-fold over control values at day 4, and decreases somewhat less rapidly to near control levels by day 10. The protein content of the epithelium decreased to about 50% of control levels at day 3, then increased linearly, and reached control values by day 10. These data are consistent with a rapid loss of cells from the olfactory epithelium following olfactory nerve section that is coincident with a marked increase in the mitogenic activity of the basal cell population.
D000818:Animals; D004261:DNA Replication; D004848:Epithelium / Q000378:metabolism; D005260:Female; D007700:Kinetics; D051379:Mice; D009297:Nasal Mucosa / Q000378:metabolism*; D009832:Olfactory Nerve / Q000502:physiology*; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors; D014316:Tritium
D014316:Tritium; D013936:Thymidine