Synthesis of N-(2-chloroethyl)-N-nitrosocarbamoyl derivatives of biologically active polypeptide hormone fragments.
N-(2-chloroethyl)-N-nitrosocarbamoyl derivatives of alpha-melanotropin and gastrin fragments were synthesized by the acylation of the peptides with active esters of N-(2-chloroethyl)-N-nitrosocarbamic acid. These compounds are supposed to be antitumor agents of low toxicity and increased selectivity.
D000970:Antineoplastic Agents; D005755:Gastrins / Q000138:chemical synthesis; D009074:Melanocyte-Stimulating Hormones / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D009607:Nitrosourea Compounds; D010446:Peptide Fragments / Q000138:chemical synthesis
D000970:Antineoplastic Agents; D005755:Gastrins; D009607:Nitrosourea Compounds; D010446:Peptide Fragments; D009074:Melanocyte-Stimulating Hormones