Role of the serotoninergic neuron system of the brain stem on the release of thyrotrophic and luteinizing hormone.
1. Decrease of brain serotonin concentration, elicited by either parachlorophenylalanine treatment, surgical interruption of the ascending serotoninergic fibres, or by pinealectomy provokes an enhanced release both of TSH and LH. 2. Increased serotonin content of the brain, produced by intraventricular, intrahypothalamic or systemic administration of serotonin, results in a significant inhibition of the release of these two trophic hormones. 3. It is concluded that the serotoninergic neuron system of the brain stem represents an inhibitory mechanism in the neuroendocrine circuit regulating pituitary trophic hormone release.
D000818:Animals; D001933:Brain Stem / Q000187:drug effects / Q000378:metabolism*; D010134:Fenclonine / Q000494:pharmacology; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000502:physiology*; D013972:Thyrotropin / Q000097:blood / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000097:blood; D013974:Thyroxine / Q000097:blood
D012701:Serotonin; D013973:Thyrotropin-Releasing Hormone; D007986:Luteinizing Hormone; D013972:Thyrotropin; D013974:Thyroxine; D010134:Fenclonine