[Effect of neuroleptanalgesia agents on the collateral coronary circulation and systemic hemodynamics in acute myocardial ischemia].
The effects of neuroleptoanalgetics on the local heart blood supply and general hemodynamics were studied in acute coronary occlusion. It was noted that droperidol, phentanyl and their combination are capable of raising the collateral coronary circulation and of maximal acceleration of the blood flow in the aorta under moderate hypotension. Administration of the increased doses of droperidol and phentanyl had an adverse effect on the blood supply of an acutely ischemized myocardium, general hemodynamics and heart contractility.
D000208:Acute Disease; D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D003097:Collateral Circulation / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004329:Droperidol / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D005283:Fentanyl / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009458:Neuroleptanalgesia
D000700:Analgesics; D004338:Drug Combinations; C001451:Innovar; D004329:Droperidol; D005283:Fentanyl
Vliianie sredstv neĭroleptanal'gezii na kollateral'noe koronarnoe krovoobrashchenie i sistemnuiu gemodinamiku pri ostroĭ ishemii miokarda.