Scintigraphy of normal mouse ovaries with monoclonal antibodies to ZP-2, the major zona pellucida protein.
The zona pellucida is an extracellular glycocalyx, made of three sulfated glycoproteins, that surrounds mammalian oocytes. Parenterally administered monoclonal antibodies specific for ZP-2, the most abundant zona protein, localize in the zona pellucida. When labeled with iodine-125, these monoclonal antibodies demonstrate a remarkably high target-to-nontarget tissue ratio and provide clear external radioimaging of ovarian tissue.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis*; D004064:Digestive System / Q000276:immunology; D004527:Egg Proteins; D005260:Female; D006023:Glycoproteins / Q000032:analysis / Q000276:immunology*; D007457:Iodine Radioisotopes; D008099:Liver / Q000276:immunology; D008297:Male; D008562:Membrane Glycoproteins; D051379:Mice; D009206:Myocardium / Q000276:immunology; D010053:Ovary / Q000032:analysis / Q000000981:diagnostic imaging* / Q000276:immunology; D010063:Ovum / Q000032:analysis*; D011877:Radionuclide Imaging; D011956:Receptors, Cell Surface; D014018:Tissue Distribution; D015044:Zona Pellucida / Q000032:analysis* / Q000276:immunology; D000072216:Zona Pellucida Glycoproteins
D000911:Antibodies, Monoclonal; D004527:Egg Proteins; D006023:Glycoproteins; D007457:Iodine Radioisotopes; D008562:Membrane Glycoproteins; D011956:Receptors, Cell Surface; D000072216:Zona Pellucida Glycoproteins; C000606520:Zp2 protein, mouse