[Accumulation of 5 alpha-dihydrotestosterone in purified plasma membranes and in the myelin of male rat hypothalamus].
The lack of 5 alpha-reductase activity in purified membranes of hypothalamic cells or in myelin was demonstrated. On the other hand, it was shown that incubation of hypothalamic slices with tritiated testosterone resulted in the accumulation and retention of 5 alpha-dihydrotestosterone in purified plasmic membranes and in myelin. The biological significance of such a retention remains unknown.
D000728:Androgens / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D013196:Dihydrotestosterone / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009186:Myelin Sheath / Q000378:metabolism*; D051381:Rats; D013739:Testosterone / Q000378:metabolism; D014316:Tritium
D000728:Androgens; D013196:Dihydrotestosterone; D014316:Tritium; D013739:Testosterone
Accumulation de 5 alpha-dihydrotestostérone dans les membranes plasmiques purifiées et la myéline de l'hypothalamus du rat mâle.