erythro-5-[1-Hydroxy-2-(isopropylamino)butyl]-7-hydroxycarbostyril, a terbutaline-type derivative of the bronchodilator procaterol.
erythro-5-[1-Hydroxy-2-(isopropylamino)butyl]-7-hydroxycarbostyril (4), which is a terbutaline-type derivative of the bronchodilator procaterol, was synthesized by transfer of the 8-hydroxyl group of procaterol to the 7 position. Compound 4 showed less potent beta-adrenoceptor stimulant activities than procaterol or terbutaline in an in vitro test using guinea pig tracheal muscle and right atrium. In an in vivo assay on anesthetized dogs, compound 4 showed 42 times less bronchodilator activity and 87 times less effect on the heart rate than l-isoproterenol.
D000818:Animals; D001993:Bronchodilator Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004983:Ethanolamines / Q000138:chemical synthesis* / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D017265:Procaterol / Q000031:analogs & derivatives
D001993:Bronchodilator Agents; D004983:Ethanolamines; C030439:5-(1-hydroxy-2-(isopropylamino)butyl)-7-hydroxycarbostyril; D017265:Procaterol