Immune-complex nephritis in the rabbit produced by injections of rat renal tubular fraction 3 antigen.
Rabbits used for the production of anti-rat kidney tubular fraction 3 antibody developed a form of immune-complex glomerulonephritis which was characterized by the deposition of immune complexes in the glomerular basement membrane and in the mesangium. The deposits were composed of the injected rat kidney antigen and rabbit antibody to the injected antigen. Eluted gamma-globulin obtained from the diseased rabbit kidneys reacted only with the brush-border region of the proximal convoluted tubules of normal rat kidney sections but not with normal rabbit kidney sections, in an indirect fluorescent antibody test. The developing kidney disease does not appear to have an autoimmune component.
D000818:Animals; D000941:Antigens; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D007105:Immune Complex Diseases / Q000209:etiology* / Q000473:pathology; D007106:Immune Sera / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis; D007678:Kidney Glomerulus / Q000648:ultrastructure; D007684:Kidney Tubules / Q000276:immunology*; D008854:Microscopy, Electron; D011817:Rabbits; D051381:Rats
D000941:Antigens; D007106:Immune Sera; D007074:Immunoglobulin G