Effect of caffeine in G2 on X-ray-induced chromosomal aberrations and mitotic inhibition in ataxia telangiectasia fibroblast and lymphoblastoid cells.
The effect of post-treatments with caffeine in G2 on the frequency of X-ray-induced chromatid aberrations was studied in normal and ataxia telangiectasia (A-T) fibroblast and lymphoblastoid cells. Caffeine was found to potentiate the X-ray-induced aberration yield in both normal fibroblast and lymphoblastoid cells. An enhancement was also observed in A-T lymphoblastoid cells, whereas the X-ray-induced aberration frequency in A-T fibroblasts was unaffected by the presence of caffeine. The influence of caffeine on the radiation-induced mitotic inhibition was investigated in normal and A-T fibroblasts; in both types of cell less inhibition was obtained in the presence of caffeine.
D001260:Ataxia Telangiectasia / Q000235:genetics*; D002110:Caffeine / Q000494:pharmacology*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000528:radiation effects; D004260:DNA Repair; D005347:Fibroblasts; D006801:Humans; D007399:Interphase / Q000187:drug effects*; D008214:Lymphocytes; D008938:Mitosis / Q000528:radiation effects*; D012854:Sister Chromatid Exchange / Q000187:drug effects; D014965:X-Rays
D002110:Caffeine