Immunologic studies of hollow-fiber dialyzer extracts.
Testing failed to detect free isocyanates in dialyzer rinses or significant levels of immunoglobulin E antibodies to isocyanate-protein conjugates in the serum of individuals reacting during hemodialysis with dialyzers containing Cuprophan membranes. Extended immunization of rabbits with Limulus lysate-reactive material from dialyzer rinses demonstrated antigenic activity of the rinse that appears to originate from cotton linters used in hollow-fiber membranes. The possibility that an immunologic response to these antigens may be a mechanism in adverse reactions to hemodialysis is discussed.
D000941:Antigens / Q000276:immunology; D002482:Cellulose / Q000031:analogs & derivatives* / Q000276:immunology; D002851:Chromatography, High Pressure Liquid; D003485:Cyanates / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000378:metabolism; D007688:Kidneys, Artificial; D008033:Limulus Test; D011852:Radioallergosorbent Test; D006435:Renal Dialysis / Q000009:adverse effects*
D000941:Antigens; D003485:Cyanates; D007073:Immunoglobulin E; D002482:Cellulose; C009865:cuprammonium cellulose; C005057:isocyanic acid