Some analogies between prebiotic thermal conversions of glycine and metabolic pathways.
The reaction schemes suggested earlier for thermal transformation of glycine into amino acids and carboxylic acids are considered in detail. Close analogy with some wide-spread biochemical reactions of amino acids is observed. The pathway suggested has some common stages with the tricarboxylic acid cycle and other metabolic processes. The possible role of alpha-imino or alpha-keto acids as prebiological analogs of pyridoxal-phosphate-containing enzymes is discussed. The thermal transformations of glycine under primitive Earth conditions could be considered as evolutionary precursors of some present-day metabolic pathways.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002952:Citric Acid Cycle; D005998:Glycine / Q000378:metabolism; D006358:Hot Temperature; D008954:Models, Biological
D000596:Amino Acids; D005998:Glycine