Suppressor mononuclear cells in giant lymph node hyperplasia and thymoma.
The existence of suppressor mononuclear cells were demonstrated in two lymphoproliferative disorders: giant lymph node hyperplasia and thymona. The three patients tested also showed cell-mediated immunodeficiency as expressed in the low number of T cells, negative graft versus host reactions and negative skin tests; the one patient tested with phytohemagglutinin (PHA) and concavalin A (Con A) showed a low response. Suppressor activity was tested with a new experimental model, the local xenogeneic graft versus host reaction. It is proposed that this model be used for testing suppressor activities in other human disorders as well.
D000293:Adolescent; D000818:Animals; D002648:Child; D002675:Child, Preschool; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006087:Graft vs Host Reaction; D006222:Hamartoma / Q000276:immunology; D006801:Humans; D006965:Hyperplasia / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology* / Q000473:pathology; D008213:Lymphocyte Activation; D008297:Male; D008954:Models, Biological; D009000:Monocytes / Q000276:immunology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D051381:Rats; D012882:Skin Tests; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013945:Thymoma / Q000276:immunology*
D010835:Phytohemagglutinins; D003208:Concanavalin A