Transient acute renal failure due to tumor-lysis-induced severe phosphate load in a patient with Burkitt's lymphoma.
A patient who developed acute renal failure during a period of acute tumor lysis is reported. Evidence is presented that hyperphosphatemia and/or hyperphosphaturia caused the acute renal failure. The literature on the subject is reviewed and pathogenetic mechanisms are discussed. Therapeutic and preventive measures are outlined.
D058186:Acute Kidney Injury / Q000209:etiology*; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D001822:Body Burden; D002051:Burkitt Lymphoma / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D008297:Male; D010710:Phosphates / Q000097:blood / Q000502:physiology* / Q000652:urine; D013577:Syndrome; D013997:Time Factors
D000970:Antineoplastic Agents; D010710:Phosphates