Pulmonary edema following high intravenous doses of ionic contrast media. Effect of the anion composition and concentration.
High intravenous doses of diatrizoate are known to induce a profound degree of pulmonary edema which is dose- and injection rate-dependent in the rat. In this study, meglumine salts of diatrizoate, iothalamate, and metrizoate were evaluated for their capacity to induce pulmonary edema following intravenous injections. Differences in anion composition or concentration of diatrizoate meglumine/sodium salts did not cause significantly different degrees of pulmonary edema.
D000818:Animals; D000838:Anions / Q000032:analysis; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000032:analysis / Q000633:toxicity*; D007275:Injections, Intravenous; D007463:Iodobenzoates / Q000633:toxicity*; D007482:Iothalamate Meglumine / Q000032:analysis / Q000633:toxicity*; D008297:Male; D008794:Metrizoic Acid / Q000032:analysis / Q000633:toxicity*; D009994:Osmolar Concentration; D011654:Pulmonary Edema / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains
D000838:Anions; D007463:Iodobenzoates; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D008794:Metrizoic Acid; D007482:Iothalamate Meglumine