Immunological disturbance in West and Lennox-Gastaut syndromes.
Cell-mediated and humoral immunity were investigated in 18 patients with West syndrome, 12 with Lennox-Gastaut syndrome and 19 healthy controls. The study included determination of T and B peripheral blood lymphocytes, serum levels of IgG, IgA and IgM, skin sensibilization with DNCB, intracutaneous PHA, leucocyte migration inhibition test and lymphocyte blastic transformation in the presence of PHA. Cell-mediated deficiency was detected in 28 children whereas low levels of immunoglobulins were observed only in 6 children. Immunological disturbances were more prominent in children with West syndrome.
D000293:Adolescent; D002464:Cell Migration Inhibition; D002648:Child; D002675:Child, Preschool; D004137:Dinitrochlorobenzene; D004827:Epilepsy / Q000276:immunology*; D005260:Female; D006429:Hemiplegia / Q000150:complications / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis; D007223:Infant; D007428:Intradermal Tests; D007962:Leukocytes / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D013036:Spasms, Infantile / Q000276:immunology*; D013577:Syndrome
D004137:Dinitrochlorobenzene; D007136:Immunoglobulins