Optically active gossypol as a circular dichroism probe of interactions with serum albumins.
The (+)-enantiomer of the polyphenolic binaphthyl gossypol, has been shown to be a useful CD probe of interactions with human and bovine serum albumin. (+)-Gossypol binds to albumin with the same affinity as racemic (+/-)-gossypol, as shown by fluorescence quenching, and also displaces bilirubin from its albumin binding site. The CD characteristics of bound gossypol are different in the case of the two proteins.
D000818:Animals; D002417:Cattle; D002942:Circular Dichroism; D006072:Gossypol; D006801:Humans; D011487:Protein Conformation; D012709:Serum Albumin; D012710:Serum Albumin, Bovine
D012709:Serum Albumin; D012710:Serum Albumin, Bovine; D006072:Gossypol