Effects of dopamine and apomorphine on gonadotropin release from the transplanted pars distalis in goldfish.
Male goldfish bearing pars distalis transplants from other male goldfish have increased serum gonadotropin (GtH) levels, due to the high spontaneous release rate of GtH by the transplants. Intraperitoneal injection of dopamine or its agonist, apomorphine, each reduced the elevated serum GtH levels caused by the release from the transplanted pars distalis. These results suggest that dopamine has GtH-release-inhibitory activity and acts directly on gonadotrophs to inhibit spontaneous secretion of GtH.
D000818:Animals; D001058:Apomorphine / Q000008:administration & dosage / Q000494:pharmacology*; D003530:Cyprinidae / Q000097:blood*; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D006054:Goldfish / Q000097:blood*; D006062:Gonadotropins / Q000097:blood*; D007274:Injections, Intraperitoneal; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects* / Q000637:transplantation
D006062:Gonadotropins; D001058:Apomorphine; D004298:Dopamine