[Toxicity of the new antidepolarizing curare-like drug diadonium].
It has been shown in acute experiments on rats, rabbits and cats that under extracorporeal pulmonary ventilation, the animals could tolerate the 50-100 fold apnoeic doses of diadonium. Chronic experiments have demonstrated that administration of the subapnoeic doses of diadonium to rats, rabbits, and dogs and the apnoeic doses to rats (under extracorporeal respiration) for 10-14 days exerts no significant effect on the peripheral blood, the main biochemical characteristics of blood serum, histological structure of the internal organs, and does not possess local irritant or hemolytic action. The data obtained indicate the safety of diadonium as a myorelaxant.
D000208:Acute Disease; D000218:Adamantane / Q000031:analogs & derivatives* / Q000633:toxicity; D000311:Adrenal Glands / Q000032:analysis; D000818:Animals; D001049:Apnea / Q000139:chemically induced; D002415:Cats; D002908:Chronic Disease; D004285:Dogs; D005260:Female; D008297:Male; D009125:Muscle Relaxants, Central / Q000633:toxicity*; D003473:Neuromuscular Nondepolarizing Agents / Q000633:toxicity*; D000644:Quaternary Ammonium Compounds / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D009125:Muscle Relaxants, Central; D003473:Neuromuscular Nondepolarizing Agents; D000644:Quaternary Ammonium Compounds; C013473:diadonium; D000218:Adamantane
O toksichnosti novogo antidepoliarizuiushchego kurarepodobnogo sredstva diadoniia.