Proglumide antagonizes the stimulation of rabbit gallbladder by cholecystokinin.
Proglumide (3 X 10(-4) to 3 X 10(-3) M) produced parallel rightward shifts in the cumulative concentration-response curves for cholecystokinin octapeptide (CCK-8) in the rabbit gallbladder. Contractile responses to acetylcholine and serotonin were inhibited noncompetitively by the highest concentration of proglumide tested. K+-induced contractions, however, were unaffected by proglumide. The results indicate that proglumide may be used as a selective, competitive antagonist of the actions of CCK-8 in the isolated rabbit gallbladder preparation.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D005260:Female; D005704:Gallbladder / Q000187:drug effects*; D005973:Glutamine / Q000031:analogs & derivatives*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D011377:Proglumide / Q000494:pharmacology*; D011817:Rabbits; D012701:Serotonin / Q000494:pharmacology
D005973:Glutamine; D012701:Serotonin; D002766:Cholecystokinin; D011377:Proglumide; D000109:Acetylcholine