Ligand-receptor relationships in immune regulation.
The relationship between ligand, idiotype-bearing ligand-binding T suppressor cells (Ts), and antiidiotypic Ts is discussed. The suppressor pathway involves the activation by ligand of first-order idiotypic Ts (Ts1) which elaborate idiotype-bearing T suppressor factors (TsF). TsF readily induced second-order antiidiotypic TS2 cells. The genetic restrictions imposed on the immune system once perturbed by antigen are evaluated.
D000818:Animals; D001391:Azo Compounds / Q000276:immunology*; D006183:H-2 Antigens / Q000276:immunology; D006241:Haptens / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007108:Immune Tolerance; D007109:Immunity; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D008024:Ligands; D008222:Lymphokines / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology; D013491:Suppressor Factors, Immunologic; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D010132:p-Azobenzenearsonate / Q000276:immunology*
D001391:Azo Compounds; D006183:H-2 Antigens; D006241:Haptens; D000949:Histocompatibility Antigens Class II; D007130:Immunoglobulin Idiotypes; D008024:Ligands; D008222:Lymphokines; D013491:Suppressor Factors, Immunologic; D010132:p-Azobenzenearsonate