Tetracycline and minocycline treatment.
The effect of 1,000 mg of tetracycline hydrochloride and 200 mg of minocycline hydrochloride on Propionibacterium acnes levels and skin-surface lipid levels was measured in 15 patients with acne. Minocycline produced a significantly greater reduction in the P acnes counts that persisted even up to three weeks after discontinuation of the minocycline therapy, in contrast to the return of P acnes to baseline counts within three weeks after discontinuation of tetracycline therapy. A similar persistence of effect for reduction of skin-surface free fatty acid levels and clinical lesions was also seen with minocycline therapy.
D000152:Acne Vulgaris / Q000188:drug therapy / Q000378:metabolism / Q000382:microbiology; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008911:Minocycline / Q000008:administration & dosage / Q000494:pharmacology*; D011425:Propionibacterium acnes / Q000187:drug effects*; D012867:Skin / Q000187:drug effects* / Q000378:metabolism / Q000382:microbiology; D013752:Tetracycline / Q000008:administration & dosage / Q000494:pharmacology*; D013754:Tetracyclines / Q000494:pharmacology*
D005230:Fatty Acids, Nonesterified; D013754:Tetracyclines; D013752:Tetracycline; D008911:Minocycline