Castleman's disease with coagulation defect. A case report.
The case of a young man with the plasma cell type of Castleman's disease is described. Beyond the well known systemic manifestations the coagulation tests showed a decrease in the activity of factors V, VIII and X due to the presence of lupus-like circulating anticoagulants. After surgical excision of the mediastinal mass both hematochemical pathological data and the coagulation defect disappeared. It is suggested that the lupus-like anticoagulant was secreted by the tumor.
D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism; D000755:Anemia, Sickle Cell / Q000150:complications; D001778:Blood Coagulation Disorders / Q000209:etiology*; D006801:Humans; D006965:Hyperplasia / Q000150:complications; D008198:Lymph Nodes / Q000473:pathology*; D008297:Male; D008479:Mediastinal Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery; D010954:Plasmacytoma / Q000000981:diagnostic imaging / Q000601:surgery; D014057:Tomography, X-Ray Computed
D000469:Alkaline Phosphatase