[Posttranslational deamidation of crystalline lens proteins during animal aging].
The amide content of total proteins and protein fractions (alpha-, beta-, gamma-cristallins and albuminoid) from cortex and nuclear lens zones of cattle has been investigated. The amide content in proteins of cortex and nuclear lens of young animals (1,5-2 years old) is the same. The decrease of the amide content in the proteins of nuclear lenz zone of old animals (6-12 years old) is due to fraction of readily hydrolysed amides. The data obtained prove the posttranslational desamidation of lens proteins at ageing. beta-Cristallines--the proteins with the highest amides content is exposed to posttranslational desamidation most of all.
D000375:Aging; D000418:Albumins / Q000378:metabolism; D000577:Amides / Q000378:metabolism; D000818:Animals; D002417:Cattle; D003459:Crystallins / Q000378:metabolism*; D003641:Deamination; D007904:Lens Cortex, Crystalline / Q000378:metabolism; D007907:Lens Nucleus, Crystalline / Q000378:metabolism; D011499:Protein Processing, Post-Translational
D000418:Albumins; D000577:Amides; D003459:Crystallins
Posttransliatsionnoe dezamidirovanie belkov khrustalika glaza pri starenii zhivotnogo.