[Absorption by rat fetal tissues of 14C-labeled phospholipids injected into the rat body in the late stages of pregnancy].
The authors studied the possibility of 14C-phospholipid transplacental penetration after 15C-phospholipid injection into rats at the 20th day of pregnancy. The preparation of 14C-phospholipids (total phospholipids) was isolated by thin-layer chromatography from the liver of rats injected with 2-14C-sodium acetate. One hour after its injection into the rat, 14C-phospholipids were detectable in total phospholipids of the pulmonary and cerebral fetal tissues. It was discovered that specific radioactivity of phospholipids contained by these tissues was 2--5 times higher when 14C-phospholipids were injected subcutaneously as compared with intramuscular injection. It is concluded that exogenous phospholipids entrapped in the mother's circulation penetrate the placental barrier of the fetus and the blood-brain barrier of the mature fetus, being consumed by different fetal tissues for forming membrane structures of the fetal tissues.
D000818:Animals; D001921:Brain / Q000196:embryology* / Q000378:metabolism; D002250:Carbon Radioisotopes; D005260:Female; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D008168:Lung / Q000196:embryology* / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D010743:Phospholipids / Q000008:administration & dosage / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D002250:Carbon Radioisotopes; D010743:Phospholipids
Pogloshchenie tkaniami ploda krys mechennykh 14C fosfolipidov, vvedennykh v organizm zhivotnogo na posledneĭ stadii beremennosti.