[Effectiveness of the rapid intravenous administration of rifampicin and isoniazid and of the intramuscular administration of streptomycin in disseminated destructive pulmonary tuberculosis in dogs].
Soluble rifampicin and isoniazid injected rapidly by the intravenous route and streptomycin injected intramuscularly to dogs with disseminated destructive tuberculosis of the lungs provided sterilization of the organs with respect to M. tuberculosis for the period of their use for 2 months. This was confirmed microbiologically. The treatment resulted in resolution of the dissemination foci in the organs and stimulation of immunomorphological and connective tissue reactions in the lungs until the foci cicatrized. The shifts in liver function (bilirubin, ALT and AST) and coagulograms during the treatment were temporary and came to normal by the end of the treatment. The organotropic effect of soluble rifampicin in combination with isoniazid injected rapidly by the intravenous route and streptomycin injected intramuscularly was not observed during the treatment of the dogs with disseminated destructive tuberculosis of the lungs. Rapid intravenous injection of rifampicin in combination with other antimicrobial drugs will provide a significant decrease in the periods of chemotherapy of patients with disseminated destructive tuberculosis of the lungs.
D000818:Animals; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D006168:Guinea Pigs; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007538:Isoniazid / Q000008:administration & dosage*; D008168:Lung / Q000382:microbiology / Q000473:pathology; D009336:Necrosis; D012293:Rifampin / Q000008:administration & dosage*; D013307:Streptomycin / Q000008:administration & dosage*; D013997:Time Factors; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology
D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin
Effektivnost' ékspressnogo vnutrivennogo vvedeniia rifampitsina, izoniazida i vnutrimyshechnogo vvedeniia streptomitsina pri rasprostranennom destruktivnom tuberkuleze legkikh u sobak.