[Effect of a tissue oxygenator (almitrine + raubasine) on the metabolism of 2,3-diphosphoglycerate of rabbits submitted by hypoxia].
In normoxic rabbits, the intravenous injection (1 mg/kg) of the product (almitrine + raubasine) do not modify the erythrocytic level of 2,3-DPG. But, after hypoxia (the rabbits being submitted to an oxygen pressure of 7,8 kPa during 20 minutes) the same dose of this product induce a durable rise of erythrocytic 2,3-DPG level which remain, 24 hours latter, + 15% above normal.
D015765:Almitrine; D000818:Animals; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D000860:Hypoxia / Q000097:blood; D007700:Kinetics; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D010879:Piperazines / Q000494:pharmacology*; D011817:Rabbits; D046948:Secologanin Tryptamine Alkaloids; D014227:Triazines / Q000494:pharmacology*; D015016:Yohimbine / Q000494:pharmacology*
D004163:Diphosphoglyceric Acids; D010879:Piperazines; D046948:Secologanin Tryptamine Alkaloids; D014227:Triazines; D015016:Yohimbine; C005709:raubasine; D015765:Almitrine; D010100:Oxygen
Effet d'un oxygénateur tissulaire (almitrine + raubasine) sur le métabolisme du 2,3-diphosphoglycérate du lapin soumis à une hypoxie.