Effect of 4-aminopyridine on gastric secretion in rats.
A study was performed in order to examine the effect of 4-Aminopyridine on gastric secretion of the rat. Acid secretion was evaluated in the stomach perfused rat preparation in anaesthetized animals. Systemic administration of the drug dose depently stimulated gastric secretion and the threshold dose was not dissimilar to that of Histamine. Atropine sulphate was able to antagonize the stimulating effect of the drug.
D015761:4-Aminopyridine; D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D051381:Rats
D000631:Aminopyridines; D001285:Atropine; D006632:Histamine; D015761:4-Aminopyridine