Streptozotocin induced diabetic nephropathy and renal tumors in the rat.
Adult Wistar rats rendered diabetic by a single dose of streptozotocin develop renal morphological changes which show subtle differences compared to those seen in human diabetic renal disease. The early tubular degeneration is sited in the distal rather than the proximal convoluted tubule and subsequent glomerular lesion shows linear deposits of IgG and albumin in the basement membrane rather than in the mesangium. The carcinogenicity of streptozotocin in the rat is reconfirmed.
D000236:Adenoma / Q000139:chemically induced; D000418:Albumins / Q000378:metabolism; D000818:Animals; D001485:Basement Membrane / Q000378:metabolism; D003928:Diabetic Nephropathies / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism; D007680:Kidney Neoplasms / Q000139:chemically induced*; D007684:Kidney Tubules / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013311:Streptozocin
D000418:Albumins; D007074:Immunoglobulin G; D013311:Streptozocin