The influence of nicotinamide, tryptophan, and methionine upon galactosamine-induced effects in the liver.
After administration of D-galactosamine-HCl alterations in liver cells - histologically resembling hepatitis - occur. During this process several biochemical changes are demonstrable. The formation of these alterations may be prevented by combined administration of nicotinamide + L-methionine or DL-tryptophan + L-methionine. This had been confirmed by histology as well as by determination of GOT and GPT activity in the serum.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000517:prevention & control*; D004347:Drug Interactions; D005260:Female; D005688:Galactosamine / Q000037:antagonists & inhibitors* / Q000633:toxicity; D008099:Liver / Q000166:cytology; D008297:Male; D008715:Methionine / Q000494:pharmacology*; D009536:Niacinamide / Q000494:pharmacology*; D011239:Prednisolone / Q000494:pharmacology; D051381:Rats; D014364:Tryptophan / Q000494:pharmacology*
D009536:Niacinamide; D005688:Galactosamine; D014364:Tryptophan; D011239:Prednisolone; D008715:Methionine; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase