Toxicological studies on Amfenac sodium (AHR-5850) (I) Acute toxicities in mice and rats.
Acute toxicities of Amfenac sodium (AHR-5850), new nonsteroidal anti-inflammatory agent, were studied in mice and rats. Each value of LD50 by oral, sc, im, iv and ip administration with this compound was 1190, 580, 540, 550 and 790 mg/kg for male mice and 1450, 625, 610, 630 and 710 mg/kg for female mice, respectively. Rats showed higher lethality than mice. There was no significant difference of sex in the values of LD50 for mice and rats. Movement and respiration rate followed by gastrointestinal ulcer, secondary peritonitis and systemic emaciation. These results suggest that the death is caused by secondary peritonitis and systemic emaciation due to gastrointestinal ulcer.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000633:toxicity*; D004064:Digestive System / Q000187:drug effects; D004614:Emaciation / Q000139:chemically induced; D005260:Female; D007077:Ileal Diseases / Q000139:chemically induced; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010538:Peritonitis / Q000139:chemically induced; D010648:Phenylacetates / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced; D014456:Ulcer / Q000139:chemically induced
D000893:Anti-Inflammatory Agents; D010648:Phenylacetates; C014285:amfenac