Thymus-dependent lymphocytes of dengue virus-infected mice spleens mediate suppression through prostaglandin.
Our earlier observations indicate that adoptive transfer of spleen cells obtained from dengue type 2 virus (DV)-primed mice suppressed DV antigen-specific antibody secretion as detected by Jerne PFC technique. Findings of this paper indicate that the suppression was produced by non-glass-adherent cells, macrophage-depleted (by carbonyl iron) cells and by T lymphocytes of the spleen but not by the glass-adherent cells and B lymphocytes. The activity of these cells is dependent upon production of prostaglandin as shown by abrogation of their suppressor activity by pre-treatment of cells by indomethacin or aspirin which are known to block synthesis of prostaglandins.
D000818:Animals; D000917:Antibody Formation; D001241:Aspirin / Q000494:pharmacology; D001402:B-Lymphocytes / Q000276:immunology; D003715:Dengue / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D007213:Indomethacin / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011453:Prostaglandins / Q000502:physiology*; D013154:Spleen / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D001241:Aspirin; D007213:Indomethacin