Targeting therapeutic plasma levels of nortriptyline from test dose plasma concentrations.
Computer programs, based on first order pharmacokinetic equations, were developed to predict steady state plasma levels and required daily maintenance doses of nortriptyline from plasma concentrations 24 hours after a test dose. These predictions are compared to clinical findings for geriatric and nongeriatric patients with a variety of accompanying medical disorders and concurrent medications.
D003201:Computers; D003866:Depressive Disorder / Q000188:drug therapy; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D009661:Nortriptyline / Q000097:blood* / Q000627:therapeutic use
D009661:Nortriptyline