Antigalactocerebroside serum demyelinates optic nerve in vivo.
Antiserum to the myelin lipid galactocerebroside (GalC) causes rapidly progressive focal demyelination when injected into guinea pig optic nerves. The capacity of anti-GalC to induce central nervous system demyelination is complement-dependent, and demyelinating activity is present in the immunoglobulin fraction of anti-GalC serum. Demyelination appears to result from primary damage to oligodendrocytes.
D000818:Animals; D002554:Cerebrosides / Q000276:immunology*; D005260:Female; D005699:Galactosylceramides / Q000276:immunology*; D006168:Guinea Pigs; D007106:Immune Sera / Q000494:pharmacology*; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000187:drug effects*; D009413:Nerve Fibers, Myelinated / Q000187:drug effects; D009836:Oligodendroglia / Q000187:drug effects; D009900:Optic Nerve / Q000187:drug effects*
D002554:Cerebrosides; D005699:Galactosylceramides; D007106:Immune Sera; C002454:galactocerebroside