Suppressor cells function in healthy persons.
The investigations were performed on lymphocytes isolated from peripheral blood of 26 healthy persons aged from 20 to 68 years. The following parameters were evaluated: T suppressor cell activity in two-step culture, concanavalin A (Con A) responsiveness in three-day culture and number of T lymphocytes carrying receptor for Fc portion of immunoglobulin G (TG cells). A slight increase in T suppressor activity and diminished responsiveness to Con A have been shown to be age-dependent. A correlation has been found between suppressor cells activity in vitro and the percentage of TG cells (r = 0.62, p less than 0.05). The level of suppressor activity of lymphocytes was independent of their Con A responsiveness.
D000328:Adult; D000368:Aged; D000375:Aging; D003208:Concanavalin A / Q000494:pharmacology; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*; D013936:Thymidine / Q000378:metabolism
D003208:Concanavalin A; D013936:Thymidine