Age and sex differences in the metabolism of C19-delta5-steroids in human amniotic epithelium.
In vitro transformation of [4-(14)C]-dehydroepiandrosterone and [4-(14)C]-5-androstenediol in human amniotic epithelium from the first and the second trimester was studied. Total conversion of both substrates used and formation of their "more polar" metabolites increased with advancing gestational age. The reduction of 17-oxo or the oxidation of 17 beta-hydroxy groups reached a maximum between weeks 17 and 20. A significant decrease in the conversion of delta 5-3 beta-hydroxy group from week 11 was evident. No significant sex differences were observed.
D000375:Aging; D000650:Amnion / Q000378:metabolism*; D000734:Androstenediols / Q000378:metabolism*; D003687:Dehydroepiandrosterone / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D005260:Female; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011262:Pregnancy Trimester, Second; D011506:Proteins / Q000032:analysis; D012737:Sex Factors
D000734:Androstenediols; D011506:Proteins; D003687:Dehydroepiandrosterone