The testing of 4CMB, 4HMB and BC for mutagenicity in a new Neurospora crassa heterokaryon.
This genetic system permits both point mutations and deletion to be detected in the same experimental material. 4CMB and BC are regarded as being mutagenic in this system. 4HMB induced mutations in only 1 of the 3 treatment protocols used, and its mutagenicity is questionable.
D001593:Benzyl Compounds / Q000494:pharmacology*; D001713:Biphenyl Compounds / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D009491:Neurospora / Q000187:drug effects*; D009492:Neurospora crassa / Q000187:drug effects*; D013045:Species Specificity; D013329:Structure-Activity Relationship
D001593:Benzyl Compounds; D001713:Biphenyl Compounds; D009153:Mutagens; C033488:4-hydroxymethylbiphenyl; C033487:4-chloromethylbiphenyl; C021292:benzyl chloride