Compared effect of propranolol and acebutolol on serum thyroid hormones' levels in euthyroid and hyperthyroid patients: a randomized study.
An open randomized study involving 57 subjects, 40 euthyroid and 17 hyperthyreotic, was undertaken to compare the effect of two beta-adrenergic blocking drugs, propranolol (120 mg/day) and acebutolol (600 mg/day), on the thyroid hormones serum level. In hyperthyreotic as well as in euthyroid subjects, propranolol evoked a fall in T3, an increase in reverse T3 and therefore a decrease in the T3/rT3 ratio. Acebutolol caused a decrease in T3 and in the T3/rT3 ratio only in euthyroid subjects. The only significant variation in the hyperthyroid acebutolol treated group was a decrease in reverse T3, perhaps spontaneous. TBG and TSH concentrations remained stable under treatment in all the groups. The relation of these effects with the existence of a membrane stabilizing activity displayed by propranolol as well as by acebutolol is discussed.
D000070:Acebutolol / Q000494:pharmacology*; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000494:pharmacology*; D011897:Random Allocation; D013963:Thyroid Hormones / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014285:Triiodothyronine, Reverse / Q000097:blood
D013963:Thyroid Hormones; D014284:Triiodothyronine; D014285:Triiodothyronine, Reverse; D000070:Acebutolol; D011433:Propranolol; D013974:Thyroxine