Thyroid hormone stimulation in vitro of red blood cell Ca2+-ATPase activity: interspecies variation.
In vitro susceptibility to thyroid hormone stimulation of membrane-associated Ca2+-ATPase activity has been examined in red blood cells from rat, rabbit, dog, monkey, and man. Monkey and human red cell Ca2+-ATPase activities responded comparably to 10(-10)M T4 or T3. Basal and thyroid hormone-stimulated Ca2+-ATPase activity in rabbit erythrocytes was four-fold higher than in primate red cells. Rat and dog red cell Ca2+-ATPase did not respond to iodothyronines in vitro.
D000818:Animals; D000252:Calcium-Transporting ATPases / Q000097:blood*; D004285:Dogs; D004910:Erythrocyte Membrane / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D008253:Macaca mulatta; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013974:Thyroxine / Q000494:pharmacology*; D014284:Triiodothyronine / Q000494:pharmacology*; D014285:Triiodothyronine, Reverse / Q000494:pharmacology*
D014284:Triiodothyronine; D014285:Triiodothyronine, Reverse; D000252:Calcium-Transporting ATPases; D013974:Thyroxine