Multiple antinuclear antibodies in mixed connective tissue disease: report of a patient with an unusual antibody profile.
A patient with antibodies to RNP, n-DNA, Sm and PM-I is described. The first clinical manifestations of connective tissue disease appeared at age 10. A cystic pulmonary lesion, pericardial effusion and nephropathy appeared after 7 years of disease limited to skin and joints. Pulmonary, pericardial and renal disease all appeared to respond to corticosteroid therapy.
D000974:Antibodies, Antinuclear / Q000032:analysis*; D002648:Child; D005260:Female; D006801:Humans; D007105:Immune Complex Diseases / Q000209:etiology; D007674:Kidney Diseases; D008947:Mixed Connective Tissue Disease / Q000150:complications / Q000276:immunology*; D012700:Serositis / Q000209:etiology
D000974:Antibodies, Antinuclear