[Intravenous theophylline therapy. Effect of solubilizers on the incidence of adverse local effects in the area of infusion?].
The frequency and intensity of discomfort and pain at the site of injection during intravenous infusion of theophylline sodium glycinate and theophylline ethylenediamine were compared in a single blind crossover study on 6 healthy adult volunteers. The preparation containing theophylline sodium glycinate was significantly better tolerated than theophylline ethylenediamine.
D000328:Adult; D004338:Drug Combinations; D005029:Ethylenediamines / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000139:chemically induced; D012996:Solutions / Q000009:adverse effects; D013806:Theophylline / Q000008:administration & dosage* / Q000009:adverse effects
D004338:Drug Combinations; D005029:Ethylenediamines; D012996:Solutions; D013806:Theophylline
Intravenöse Theophyllintherapie. Einfluss des Lösungsvermittlers auf die Häufigkeit lokaler unerwünschter Wirkungen im Infusionsbereich?