[Electrophysiology of the peripheral effect of two analgesics: aspirin and dibencozide].
The peripheral effect of two analgesics (aspirin and dibencozide) was studied on anaesthetized cats. Several types of neurons and stimulations were performed in this work: traction for periodontal mechanoreceptors connected to small-sized trigeminal fibres, distension for the muscular intestinal mechanoreceptors connected to non-myelinated vagal fibres, chemical stimulation by means of phenyldiguanide for the non-myelinated vagal fibres, electrical stimulation of the myelinated and non-myelinated vagal fibres. In all cases, unitary activities were recorded into corresponding ganglia (nodose or gasserian) with extracellular glass microelectrodes. After injection of analgesics, a decrease of control responses were observed till 30 minutes but the maximum occurred between 1 and 5 minutes. This effect concerned the non-myelinated neurones as well as the myelinated ones. It can be explained by a direct action of analgesics on the ending excitability.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D002415:Cats; D003038:Cobamides / Q000494:pharmacology*; D007700:Kinetics; D008465:Mechanoreceptors / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D014630:Vagus Nerve / Q000187:drug effects / Q000502:physiology*
D003038:Cobamides; C000913:cobamamide; D001241:Aspirin
Etude électrophysiologique de l'effet périphérique de deux substances antalgiques: l'aspirine et le dibencozide.