Penicillamine-induced lupus-like reaction in rheumatoid arthritis and vasculitis.
A 44-year-old woman with rheumatoid arthritis and vasculitis of the skin developed a lupus erythematosus-like reaction after 5 weeks of D-penicillamine therapy. The diagnosis was established on the clinical and histological picture, immunofluorescence studies and serological investigations. The reaction faded upon cessation of the drug.
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology; D003875:Drug Eruptions / Q000209:etiology* / Q000276:immunology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000276:immunology; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000188:drug therapy* / Q000276:immunology
D000974:Antibodies, Antinuclear; D010396:Penicillamine