Changes in collagen fibril diameters in a lathyritic connective tissue.
Collagen fibril diameters were measured in molar and incisor periodontal ligaments of adult rats given aminoacetonitrile (0.15% in their drinking water). Fibrils were also measured in the periodontal ligaments of pair-fed control animals and animals fed ad libitum. The lathyrogen produced a significant change in the distribution of fibril diameters in both molars and incisors and an increase in mean fibril diameter in incisors relative to pair-fed controls. The reduced food intake of the pair-fed control group produced a significant decrease in mean fibril diameter in incisors relative to the ad libitum control group. These results that lathyrogens may affect collagen fibril diameters in an adult connective tissue in a manner similar to that previously shown for a fetal tissue.
D000607:Aminoacetonitrile; D000818:Animals; D003094:Collagen / Q000378:metabolism*; D003238:Connective Tissue / Q000648:ultrastructure*; D007180:Incisor; D007842:Lathyrism / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D008963:Molar; D010513:Periodontal Ligament / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains
D000607:Aminoacetonitrile; D003094:Collagen