Endotoxin shock in the pig: beneficial effects of pretreatment with prednisolone sodium succinate.
In anesthetized pigs, the influence on cardiovascular performance and on survival rate of IV administration of a large dose of endotoxin (0.5 mg/kg of body weight) was examined. This dose of endotoxin (LD100) resulted in a progressively evolving deterioration of cardiovascular functions and in the death of all animals within 210 minutes (mean +/- SEM: 107 +/- 13 minutes) after it was given. The IV injection of prednisolone sodium succinate, 10 mg/kg at 25 minutes before dosing the pigs with endotoxin resulted in a significant increase in survival time. This effect of the glycocorticoid can only partly be ascribed to an amelioration of the cardiovascular dysfunctions.
D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects; D005260:Female; D011239:Prednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D012772:Shock, Septic / Q000401:mortality / Q000517:prevention & control / Q000662:veterinary*; D013552:Swine; D013553:Swine Diseases / Q000401:mortality / Q000517:prevention & control*; D013997:Time Factors
D011239:Prednisolone; C021322:prednisolone hemisuccinate