[Polyradiomodification. Evaluation of the efficacy of the use of hyperglycemia during experimental hypoxic radiotherapy of tumors].
The authors give an experimental evaluation of the appropriateness of the use of short-term hyperglycemia combined with hypoxiradiotherapy of solid tumors. In comparing the response of tumors and overlying skin a conclusion has been made that gaseous hypoxia and the use of hyperglycemia separately yield in a considerable therapeutic benefit, and the use of the combination of these agents in some cases produces a greater therapeutic interval between tumor destruction and normal tissues. The mechanisms of the modification of radiation injuries of tumors and skin under the influence of the above two factors are discussed.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002286:Carcinoma, Ehrlich Tumor / Q000097:blood / Q000473:pathology / Q000532:radiotherapy*; D002455:Cell Division / Q000528:radiation effects; D005947:Glucose / Q000494:pharmacology; D008297:Male; D051379:Mice; D010100:Oxygen / Q000494:pharmacology*; D010101:Oxygen Consumption; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000517:prevention & control; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage; D012867:Skin / Q000378:metabolism / Q000528:radiation effects
D001786:Blood Glucose; D005947:Glucose; D010100:Oxygen
Poliradiomodifikatsiia. Otsenka éffektivnosti ispol'zovaniia giperglikemii pri éksperimental'noĭ gipoksiradioterapii opukholeĭ.