[H-Y antigen and sexual dysgenesis in man].
H-Y antigen is a surface component associated with the heterogametic sex of various species and supposed to induce testicular differentiation. Genes controlling directly or not the expression of H-Y antigen and testicular differentiation have been localized on Y as well as on X chromosome and even autosomal chromosome. However the genetical localization of the H-Y structural gene remains unknown. We analysed the expression of H-Y antigen in three types of sexual dysgenesis (males bearing XX caryotype, testicular feminization syndrome and one case of hermaphroditism) to clarify the function and the genetics of this antigen.
D013734:Androgen-Insensitivity Syndrome / Q000235:genetics; D000818:Animals; D002872:Chromosome Deletion; D012734:Disorders of Sex Development / Q000235:genetics; D005260:Female; D006059:Gonadal Dysgenesis / Q000235:genetics*; D006182:H-Y Antigen / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D010641:Phenotype; D051381:Rats; D014424:Turner Syndrome / Q000235:genetics
D006182:H-Y Antigen
Antigèn H-Y et dysgénésies sexuelles chez l'Homme.