Comparative analysis of circadian rhythms of certain functional indicators of the cardiovascular system in healthy subjects and in patients with ischaemic heart disease.
The circadian rhythm of certain functional indicators of the cardiovascular system was investigated in 141 patients with ischaemic heart disease (IHD), of whom 65 had post-infarction cardiosclerosis and in 26 healthy subjects. The obtained data were processed by an ES-1020 computer according to a special "Cosinor" programme. Specific circadian rhythm was determined of certain haemodynamic indicators, sinus node excitability, impulse conduction, myocardial supply (according to ECG data) and of the blood clotting system. In healthy subjects, the coincidence of the acrophases of circadian rhythms of functional indicators of the cardiovascular system was found; these indicators reached their maximum level during the day and in the evening. In patients with IHD (with prior myocardial infarction as well as without), there were found shifts in the circadian rhythm of bioelectrical processes in the myocardium, with the maximum values shifted to the night and morning hours. These shifts are a consequence of changes in myocardial nutrition and of worsened coronary flow during the day and in the early evening hours, when the patients exhibit also a tendency towards increased activity of the blood clotting system, as well as fibrinolysis depression.
D001777:Blood Coagulation; D001794:Blood Pressure; D002302:Cardiac Output; D002940:Circadian Rhythm; D003327:Coronary Disease / Q000503:physiopathology*; D004562:Electrocardiography; D006339:Heart Rate; D006801:Humans; D008875:Middle Aged