Deposition of C4-binding protein and beta 1H globulin in kidneys of patients with IgA nephropathy.
A study on the deposition of complement control proteins in renal tissues from patients with IgA nephropathy is described. Renal biopsy specimens were obtained from patients with IgA nephropathy and other glomerular diseases. These biopsy samples were stained with antisera to human C4-binding protein and beta 1H globulin by indirect immunofluorescent staining. It was shown that the complement system is activated in IgA nephropathy via the both alternative and classical pathways.
D002352:Carrier Proteins / Q000378:metabolism*; D003167:Complement Activation; D003180:Complement C3b Inactivator Proteins / Q000378:metabolism*; D003181:Complement C4 / Q000378:metabolism*; D017242:Complement Factor H; D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism*; D016167:Integrin alphaXbeta2; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000378:metabolism*
C493495:CFH protein, human; D002352:Carrier Proteins; D003180:Complement C3b Inactivator Proteins; D003181:Complement C4; D007070:Immunoglobulin A; D016167:Integrin alphaXbeta2; D017242:Complement Factor H