Immunodeficiencies in Hodgkin's disease. Part I: T cell-mediated immunity.
Almost every T cell-mediated immune defect has been observed in patients with Hodgkin's disease. These immune defects are present as early as Stage I disease. T cell-mediated immune defects appears to be due to both cellular and serum factors. The demonstrable immune defects found in family members, including spouses, suggest a horizontal transmission of disease, perhaps by a virus. However, these family studies remain to be confirmed and extended to twins who do not live together.
D002455:Cell Division; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes / Q000209:etiology*; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008934:Mitogens / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D008934:Mitogens