[Experimental studies on the reparative processes of infarcted capital femoral epiphysis in puppies--with special reference to the correlation of radionuclide (99mTc-MDP) uptake with radiological and pathohistological changes (author's transl)].
To investigate the correlation of radiological and pathohistological changes with radionuclide (99mTc-methylene diphosphonate) uptake, avascular necrosis of the femoral capital epiphysis of puppies was produced after the modified method of Henard and Calandruccio, by casting the hip joint in the position of hyperextention, full internal rotation and abduction for eighteen to twenty hours. Seventy-six puppies were divided into three groups according to frequency and time intervals of casting; in group A the animals were cast once, in group B cast twice with one week interval between the 1st and 2nd casting and in group C cast twice as group B but with four-week interval. Radiological, pathohistological changes and RI uptake in the capital femoral epiphysis were sequentially studied at certain intervals (1, 3, 5, 9, 15 and 20 weeks after the 1st casting). The results were as follows: 1) The radiological and pathohistological changes in the upper parts of the femora were simulated to those of human LCPD. At three to five weeks after the 1st casting (in group B and C, after the 2nd casting) radionuclide (99mTc-MDP) accumulation in the capital femoral epiphysis decreased compared with the healthy side. At this point X-ray showed coxa plana or vara and sclerotic changes in ossific nucleus, and "head within a head" feature was recognized in several cases. Pathohistologically, osseous healing and connective tissue invasion into the marrow spaces were recognized surrounding the central necrotized focus with multifarious features. 2) Radiologically in the cases of groups B and C, more severe deformities of the femoral head such as coxa vara and/or coxa plana were noted than in group A. 3) As to the RI accumulation, for 3 to 5 weeks after the last casting RI uptake was shown to decrease and then gradually increase compared with the healthy side, and this tendency was more conspicuous in group C than in groups A and B. It can be concluded that 99mTc-MDP is accumulated greatly at the site of active osteogenesis.
D000818:Animals; D004164:Diphosphonates / Q000378:metabolism; D004285:Dogs; D005271:Femur Head Necrosis / Q000000981:diagnostic imaging* / Q000473:pathology; D011859:Radiography; D011877:Radionuclide Imaging; D013667:Technetium / Q000378:metabolism; D013669:Technetium Tc 99m Medronate; D014945:Wound Healing
D004164:Diphosphonates; D013667:Technetium; D013669:Technetium Tc 99m Medronate