[Comparative studies on toxicity of various dielectrics, petroleum derivatives, used in electroerosion technology. IV. Morphological and cytoenzymatic changes in the lungs and acid-base imbalance in rats chronically exposed to petroleum hydrocarbons].
In rats exposed to odourless kerosene of 75 and 300 mg/m3 concentration, for 14 weeks, morphologic and cytoenzymatic examinations of lungs have been carried out and acid-base equilibrium indices in blood have been determined. Passive congestion of lung parenchyma, subpleural blood extravasation, atelectasis foci, thickened interalveolar septa with infiltrates from neutrophils, lymphocytes, eosinophils and macrophages have been found. In addition a decrease in succinic dehydrogenase activity, NADPH -- tetrazolium reductase, and Mg++-ATP-ase and increase in acid phosphatase activity have been revealed. Those have been focal changes, involving, apart from bronchial tree (low exposure -- 75 mg/m3), the remaining lung parenchyma segments (high exposure -- 300 mg/m3). In addition, disturbances in acid-base equilibrium in form of compensated metabolic alkalosis (75 mg/m3) and compensated metabolic acidosis (300 mg/m3) have occurred. The obtained results demonstrate toxic effects of kerosene hydrocarbons on the function and structure of lungs.
D000135:Acid Phosphatase / Q000378:metabolism; D000136:Acid-Base Equilibrium; D000137:Acid-Base Imbalance / Q000139:chemically induced*; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D003516:Cycloparaffins / Q000633:toxicity*; D008168:Lung / Q000378:metabolism* / Q000473:pathology; D008297:Male; D009246:NADH Tetrazolium Reductase / Q000378:metabolism; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013997:Time Factors
D003516:Cycloparaffins; D013385:Succinate Dehydrogenase; D009246:NADH Tetrazolium Reductase; D000135:Acid Phosphatase; D000251:Adenosine Triphosphatases
Porównawcze badania nad toksycznościa niektórych dielektryków pochodnych ropy naftowej stosowanych w obróbce elektroerozyjnej. IV. Zmiany morfologiczne i cytoenzymatyczne w płucach oraz zaburzenia równowagi kwasowo-zasadawej u szczurów przewlekle eksponowanych na weglowodory nafty.