[Are HBsAg positive viral hepatitis and its fate caused by the genetically determined immune response to the infection?].
The Authors, after a review of the latest researches about the immunopathogenesis of hepatitis B, propose a new hypothesis that points out the importance of antigen-specific suppressor T-lymphocyte activity for the evolution of hepatitis-B-virus infection. It is possible to verify this working hypothesis by employing a modified migration inhibition factor test, using preparations of isolated T-lymphocytes.
D000914:Antibodies, Viral / Q000276:immunology*; D002464:Cell Migration Inhibition; D005802:Genes, MHC Class II; D006509:Hepatitis B / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology; D006801:Humans; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014764:Viral Proteins
D000914:Antibodies, Viral; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D014764:Viral Proteins
L'epatite virale HBsAg positiva ed il suo destino evolutivo sono dovuti alla risposta immunitaria, geneticamente determinata, verso l'infezione?