Immunohistology of normal and ovarian cancer tissue with a monoclonal antibody to placental alkaline phosphatase.
A monoclonal antibody, designated NDOG2, has been shown to react with placental alkaline phosphatase. It does not bind to liver, kidney, bone, or intestinal alkaline phosphatase enzymes and has shown a positive reaction with all of over 50 placentae. Immunohistological studies have shown (a) a reaction with respiratory bronchiolar epithelium of lung, endocervical gland epithelium, the epithelium of fallopian tube, and certain reticular cells in the thymic medulla; (b) no detectable staining with ten other normal tissues including testis and tonsil; and (c) a significant reaction with nine of 13 ovarian cystadenocarcinomas and little or no staining with four malignant ovarian tumors of other histopathological types. The NDOG2 antibody may be of value as a marker in patients with ovarian cystadenocarcinoma.
D000328:Adult; D000469:Alkaline Phosphatase / Q000032:analysis*; D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D003429:Cross Reactions; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007527:Isoenzymes / Q000032:analysis; D010051:Ovarian Neoplasms / Q000201:enzymology* / Q000473:pathology; D010053:Ovary / Q000166:cytology / Q000201:enzymology*; D010920:Placenta / Q000201:enzymology*
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D007527:Isoenzymes; D000469:Alkaline Phosphatase