Evolution of the hyperandrogenism-polycystic ovary syndrome from isosexual precocious puberty: report of two cases.
Two girls who presented initially with isosexual precocity later developed the hyperandrogenism-polycystic ovary syndrome. We propose that the pathogenesis of the hyperandrogenism-polycystic ovary syndrome in these two children is related to an abnormal release of hypothalamic gonadotropin-releasing hormone, a subsequent sustained secretion of luteinizing hormone, and a consequent excessive secretion of ovarian androgens that results in hyperandrogenism. The clinical findings in these patients suggest that the dysfunction of the hypothalamic-pituitary regulation of luteinizing hormone secretion that leads to the hyperandrogenism-polycystic ovary syndrome may occur prior to puberty.
D000293:Adolescent; D000728:Androgens / Q000378:metabolism*; D001940:Breast / Q000254:growth & development; D002648:Child; D002675:Child, Preschool; D005260:Female; D006197:Hair / Q000254:growth & development; D006728:Hormones / Q000097:blood / Q000652:urine; D006801:Humans; D007223:Infant; D011085:Polycystic Ovary Syndrome / Q000209:etiology*; D011629:Puberty, Precocious / Q000150:complications*; D014626:Vaginal Smears
D000728:Androgens; D006728:Hormones