[Compounds with presumable antitumor activity. II. 2-Substituted 3-(2-thiazolyl) and 3-[2-(1,3,4,-thiadizolyl)]-4-thiazolidinones].
2-Substituted 3-(2-thiazolyl) and 3-[2-(1,3,4-thiadiazolyl)]-4-thiazolidinones were prepared and tested for their activity against the leukemic P 388 tumor system in mice. The thiadiazolyl derivatives are generally more active than the thiazolyl ones and some of them showed significant activity.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D013830:Thiadiazoles; D013844:Thiazoles
Composti a presumibile attività antitumorale. 3-(2-Tiazolil) e 3-[2-(1,3,4-tiadiazolil)]-4-tiazolidinoni 2-sostituiti.