Genetic analysis of adenine-3 mutants induced by hycanthone, lucanthone and their indazole analogs in Neurospora crassa.
Ad-3 mutants induced by hycanthone, lucanthone and their indazole analogs, IA-3, IA-4 and IA-5 were studied to characterize the genetic alterations produced by these agents in Neurospora crassa. The results of genetic analysis indicate that, in marked contrast to past experiments with chemical mutagens on heterokaryon 12, all of these antischistosomal agents induce a very high frequency of multilocus deletions.
D000225:Adenine / Q000378:metabolism*; D002875:Chromosomes / Q000187:drug effects; D005816:Genetic Complementation Test; D006826:Hycanthone / Q000031:analogs & derivatives / Q000633:toxicity*; D007191:Indazoles / Q000633:toxicity*; D008154:Lucanthone / Q000031:analogs & derivatives* / Q000633:toxicity*; D009153:Mutagens; D009492:Neurospora crassa / Q000235:genetics; D011720:Pyrazoles / Q000633:toxicity*; D013892:Thioxanthenes / Q000633:toxicity*
D007191:Indazoles; D009153:Mutagens; D011720:Pyrazoles; D013892:Thioxanthenes; D006826:Hycanthone; D008154:Lucanthone; D000225:Adenine