DNA sequence analysis of prm-mutations of coliphage lambda.
Nucleotide sequence changes associated with mutation of the prm promoter of bacteriophage lambda have been determined. Prm-mutations have been assigned to two classes. Class I mutations appear to affect the interaction of RNA polymerase with prm; six class I mutations affect four sites, located 14, 33, 38, and 39 bp preceding the prm transcription startpoint. Class II mutations appear to owe their Prm-phenotype to a change in OR, which could prevent activation of prm by repressor. All three class II mutations are in OR 1.
D010582:Bacteriophage lambda / Q000235:genetics*; D001483:Base Sequence; D005809:Genes, Regulator; D005814:Genes, Viral; D009154:Mutation; D009876:Operon; D012318:RNA Polymerase I / Q000378:metabolism; D012097:Repressor Proteins / Q000378:metabolism
D012097:Repressor Proteins; D012318:RNA Polymerase I