[Pharmacological activity of modified analogs of steroid estrogens. Racemic 8-isoestradiol].
The authors have studied pharmacological activity of an estradiol isoanalog-8-isoestradiol. The drug has been shown to possess dissociated hormonal properties. Having a relatively high vaginotropic and antifertile activity, the drug exerts a negligible antigonadotropic effect on the pituitary and a fairly weak uterotropic action.
D000818:Animals; D003283:Contraceptives, Postcoital, Synthetic / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013737:Testis / Q000187:drug effects; D014599:Uterus / Q000187:drug effects; D014621:Vagina / Q000187:drug effects; D014626:Vaginal Smears
D003283:Contraceptives, Postcoital, Synthetic; D004958:Estradiol
Izuchenie farmakologicheskoĭ aktivnosti modifitsirovannykh analogov steroidnykh éstrogenov. Ratsemicheskiĭ 8-izoéstradiol.