Dissolution rate of cholesterol in monooctanoin.
Monooctanoin is used clinically for dissolution of common bile duct cholesterol gallstones. A number of factors influencing the dissolution rate of cholesterol monohydrate in this solvent were investigated. Water increased cholesterol dissolution rate in a manner inconsistent with previous solubility measurements. Dissolution rate increased approximately 50% in the presence of 10 to 15% water in monooctanoin. Further studies on viscosity, the effect of polymers and temperature showed that the solvent viscosity had a dominating influence on dissolution rate. This was thought to be caused by the interaction of cholesterol with the solvent in the dissolving surface layer which caused a decrease in the diffusion coefficient (and dissolution rate) of cholesterol. Reducing viscosity and increasing temperature were identified as possible approaches for increasing cholesterol gallstone dissolution rate in monooctanoin.
D002210:Caprylates; D002769:Cholelithiasis / Q000188:drug therapy; D002784:Cholesterol; D005989:Glycerides / Q000494:pharmacology*; D012995:Solubility; D014783:Viscosity; D014867:Water
D002210:Caprylates; D005989:Glycerides; D014867:Water; D002784:Cholesterol; C025343:monooctanoin