Familial juvenile generalized pustular psoriasis.
The acral form of generalized pustular psoriasis is characterized by macroscopic pustules surmounting erythematous plaques that may progress from a localized distal eruption to involve the entire cutaneous surface. Juvenile-onset and familial-generalized pustular psoriasis are rare; familial-juvenile-generalized pustular psoriasis is exceptionally uncommon. A kindred of three children in the same generation had chronic, localized-acral pustular psoriasis and episodic-generalized pustular psoriasis.
D000169:Acrodermatitis / Q000235:genetics; D000293:Adolescent; D000328:Adult; D002908:Chronic Disease; D005260:Female; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007169:Impetigo / Q000235:genetics; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D010375:Pedigree; D011565:Psoriasis / Q000188:drug therapy / Q000235:genetics* / Q000276:immunology / Q000473:pathology
D006680:HLA Antigens; D008727:Methotrexate