Falsely prolonged prothrombin time due to an inhibitor to human thromboplastin.
A patient with nephrotic syndrome of unknown aetiology was found to have a grossly prolonged prothrombin time in the absence of any other coagulation abnormality and with no clinical bleeding problem. Subsequent investigations showed his plasma contained an inhibitor-like substance, directed against human but not animal thromboplastin.
D006801:Humans; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000097:blood; D011517:Prothrombin Time; D013045:Species Specificity; D013925:Thromboplastin / Q000037:antagonists & inhibitors*
D013925:Thromboplastin