Effect of phenylephrine hydrochloride on conjunctival PO2.
Phenylephrine hydrochloride eyedrops induce vasoconstriction through alpha-adrenergic mechanisms. Ten subjects underwent a 46% reduction in conjunctival PO2 when 2.5% phenylephrine eyedrops were administered. Compared with a control group, this reduction was significant. The induced conjunctival hypoxia lasted about 80 minutes. These findings suggest a number of clinical implications.
D000328:Adult; D003228:Conjunctiva / Q000187:drug effects*; D006801:Humans; D009883:Ophthalmic Solutions; D010100:Oxygen; D010313:Partial Pressure; D010656:Phenylephrine / Q000008:administration & dosage / Q000494:pharmacology*; D014331:Tropicamide / Q000008:administration & dosage / Q000494:pharmacology
D009883:Ophthalmic Solutions; D010656:Phenylephrine; D014331:Tropicamide; D010100:Oxygen