Dapsone hypersensitivity. The sulfone syndrome revisited.
A hypersensitivity reaction to low-dose (50-mg), short-term dapsone administration developed in a 16-year-old girl. The reaction included fever, malaise, dermatitis, jaundice with hepatic dysfunction, lymphadenopathy, and hemolytic anemia. Physicians should be familiar with this "sulfone syndrome," an uncommon, potentially serious, side effect of dapsone therapy.
D000152:Acne Vulgaris / Q000188:drug therapy; D000293:Adolescent; D000743:Anemia, Hemolytic / Q000209:etiology; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D003622:Dapsone / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology; D004342:Drug Hypersensitivity / Q000175:diagnosis*; D005260:Female; D006801:Humans; D008206:Lymphatic Diseases / Q000139:chemically induced; D013577:Syndrome
D003622:Dapsone