Fatal maprotiline intoxication.
We report a fatal case of drug toxicity associated with torsade de pointes following an overdose of the tetracyclic antidepressant, maprotiline (Ludiomil). Tissue and plasma levels were obtained at autopsy and are noted. In addition, the cardiovascular effects, pharmacokinetics, and toxicity of maprotiline are reviewed and compared with that of tricyclic antidepressants.
D000328:Adult; D000873:Anthracenes / Q000506:poisoning*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007700:Kinetics; D008376:Maprotiline / Q000378:metabolism / Q000506:poisoning*; D013610:Tachycardia / Q000139:chemically induced* / Q000503:physiopathology
D000873:Anthracenes; D008376:Maprotiline