A new therapeutic antibody removal method using antigen-positive red cells. II. Application to a P-incompatible pregnant woman.
Therapeutic antibody removal using antigen-positive red cells was applied to a pregnant woman who has high titered IgG anti-P and had lost all of 4 previous fetuses in P-incompatible pregnancy. The treatment was commenced at the 6th week of gestation and was intensively performed 93 times up to the 35th week. The volume of plasma treated was 2.3 1 per procedure on the average and totalled 215 1. The antibody titer was kept at a low level. At the end of the 35th week of gestation a female infant was delivered by cesarean section. The baby did not require an exchange transfusion and encountered no complications.
D000026:Abortion, Habitual / Q000209:etiology; D000328:Adult; D000653:Amniotic Fluid / Q000032:analysis; D000937:Antigen-Antibody Reactions; D001663:Bilirubin / Q000032:analysis; D001769:Blood; D001789:Blood Group Antigens / Q000276:immunology*; D001787:Blood Group Incompatibility / Q000628:therapy*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000302:isolation & purification*; D007519:Isoantigens / Q000276:immunology; D007567:Jaundice, Neonatal / Q000209:etiology; D010127:P Blood-Group System / Q000276:immunology*; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000628:therapy*; D014462:Ultrafiltration
D001789:Blood Group Antigens; D007518:Isoantibodies; D007519:Isoantigens; D010127:P Blood-Group System; D001663:Bilirubin