Immunologic mechanism of childhood renal diseases.
Antigen-antibody complexes and antibasement antibodies are involved in the pathogenesis of most immune-mediated renal diseases. The major feature of these two kidney tissue-damaging mechanisms, and their interrelations with amplification systems (complement, coagulation, and kinin) are outlined. A brief discussion of current immunologic concepts applicable to representative experimental models and pediatric nephropathies, and of their immunohistopathologic and ultrastructural expressions is presented.
D000293:Adolescent; D000906:Antibodies / Q000276:immunology; D000917:Antibody Formation; D000936:Antigen-Antibody Complex / Q000276:immunology*; D001485:Basement Membrane / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003165:Complement System Proteins / Q000276:immunology; D005921:Glomerulonephritis / Q000209:etiology / Q000276:immunology; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D011695:IgA Vasculitis / Q000276:immunology; D007105:Immune Complex Diseases / Q000276:immunology* / Q000473:pathology; D007136:Immunoglobulins / Q000276:immunology; D007668:Kidney / Q000276:immunology* / Q000473:pathology; D007674:Kidney Diseases / Q000276:immunology* / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D013290:Streptococcal Infections / Q000150:complications; D014657:Vasculitis / Q000276:immunology
D000906:Antibodies; D000936:Antigen-Antibody Complex; D000949:Histocompatibility Antigens Class II; D007136:Immunoglobulins; D003165:Complement System Proteins