T-2 toxin effect on bacterial infection and leukocyte functions.
The effects of T-2 toxin on bacterial infection and leukocyte function and structure were examined in vivo and in vitro. Rats were innoculated with staphylococci after pretreatment with or without T-2 toxin. The T-2 pretreated rats failed to mount a cellular response to the bacteria. Blood and bone marrow cells were markedly suppressed by the T-2 toxin, the myeloid series being the most affected. In vitro studies with human leukocytes showed that small, nonkilling doses of T-2 toxin inhibited chemotaxis, chemiluminescence stimulated by bacteria, and phagocytosis of bacteria. It was concluded that this inhibition may contribute towards sepsis and rapid onset of death in T-2 toxin poisoning.
D000818:Animals; D001769:Blood / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects; D002633:Chemotaxis / Q000187:drug effects; D006801:Humans; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects* / Q000473:pathology; D008297:Male; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D012717:Sesquiterpenes / Q000494:pharmacology*; D013203:Staphylococcal Infections; D013605:T-2 Toxin / Q000494:pharmacology*
D012717:Sesquiterpenes; D013605:T-2 Toxin