Antibody in host defense against mouse pneumonitis agent (murine Chlamydia trachomatis).
In a murine model of chlamydial pneumonia employing murine Chlamydia trachomatis, immune serum given intranasally delayed death in nude (nu/nu) mice and prevented death in nu/+ mice. Serum-derived immunoglobulin G and A fractions and immune lavage fluid fractions containing immunoglobulins G and A were effective in producing protection when used to opsonize the murine C. trachomatis inoculum. In hyperclean mice (previously made germfree and then colonized with a limited flora nonpathogenic to mice) antibody given intravenously was ineffective. The effects of antibody and nonspecific stimulation of cell-mediated immunity (after previous infection with Histoplasma capsulatum) were additive in increasing host resistance to murine C. trachomatis.
D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology*; D002692:Chlamydia trachomatis / Q000276:immunology*; D007111:Immunity, Cellular; D007116:Immunization, Passive; D051379:Mice; D008819:Mice, Nude / Q000276:immunology; D011014:Pneumonia / Q000276:immunology* / Q000382:microbiology
D000907:Antibodies, Bacterial