MLR inhibitory activity of pretransplant anti-donor B cell antibodies, and kidney graft survival.
The prognostic significance of different types of pretransplant anti-donor B cell antibodies on graft outcome was studied in 193 cadaver kidney recipients. Additionally, in 84 combinations the MLR inhibitory activity of patient sera was determined, and the relationship of pretransplant anti-donor B cell antibodies, MLR inhibitory activity in graft outcome was analysed. Graft survival was high in recipients with cold B cell antibodies, whereas it was unfavourable in recipients positive for warm B cell antibodies. MLR inhibitory activity was highly correlated with the latter type of antibody. In patients with high pretransplant MLR inhibitory activity graft outcome was significantly impaired. In recipients wild cold-reactive B cell antibodies who had excellent graft outcome, MLR inhibitory activity was not demonstrable.
D000906:Antibodies / Q000032:analysis / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D003080:Cold Temperature; D006085:Graft Survival; D006648:Histocompatibility; D006801:Humans; D016030:Kidney Transplantation; D007959:Lymphocyte Culture Test, Mixed
D000906:Antibodies