The effect of a milk diet on the retention of 74As labelled arsenic in mice.
The effect of 3 diets with different proportion of milk proteins on retention of arsenic was studied in mice. Arsenic was administered via drinking water in concentration 50 mg As [III] per litre labelled with 74As in amount 2.96 MBq per 100 ml. After 2, 4, 8, 16 and 32 days of exposure the mice in groups of 6 each from all 3 experimental cohorts were decapitated and the content of 74As was determined in whole body, blood, liver, kidneys, spleen, lungs and heart by measuring of the activity in Gamma Scintillation Counter Tesla. From the intake of drinking water and amount of arsenic found in the experimental animals was calculated retention of arsenic in mice at different exposure intervals in all three diets. The values of arsenic found at the exposure intervals in examined materials of all three experimental cohorts were compared. The results obtained indicate that a milk diet has no adverse effect at exposure to arsenic in the sense of enhancing of its retention in mice at given experimental conditions. The found data seemed to suggest that the milk protein rich diet caused retardation of the increase of arsenic concentrations in blood, liver and kidneys that might lead at a lower exposure rate to a decrease in arsenic content in tissues of exposed animals.
D000818:Animals; D001151:Arsenic / Q000378:metabolism*; D004032:Diet; D051379:Mice; D008813:Mice, Inbred ICR / Q000378:metabolism; D008894:Milk Proteins / Q000494:pharmacology*; D011868:Radioisotopes; D013047:Specific Pathogen-Free Organisms; D013997:Time Factors; D014018:Tissue Distribution
D008894:Milk Proteins; D011868:Radioisotopes; D001151:Arsenic