[Immunogenic properties of epidemic and recombinant strains of influenza viruses H1N1 and H3N2].
The study of the immunogenic properties of epidemic influenza viruses H1N1 and H3N2 isolated from patients in 1979-1982 revealed a high immunogenic activity of H3N2 viruses. Recombinant strains of both subtypes (H1N1 and H3N2) had a higher immunogenicity than the original viruses. The intensity of immunity determined for an antigenically close pathogenic strain was considerably higher than for an antigenically remote pathogenic virus which is important for obtaining accurate information on the immunogenic activity of influenza viruses. No correlation between the immunity intensity and the antibody titres was observed.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D007114:Immunization; D053118:Influenza A Virus, H1N1 Subtype; D053122:Influenza A Virus, H3N2 Subtype; D009980:Influenza A virus / Q000276:immunology* / Q000302:isolation & purification / Q000472:pathogenicity; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000276:immunology / Q000401:mortality; D011995:Recombination, Genetic; D013997:Time Factors
D000914:Antibodies, Viral
Immunogennye svoĭstva épidemicheskikh i rekombinantnykh shtammov virusov grippa H1N1 i H3N2.