Thymidine-kinase activity of cultured cells from individuals with inherited galactokinase deficiency.
Cells of a person homozygous for galactokinase deficiency and of her heterozygous parents were found to be deficient in the enzyme thymidine kinase. The decrease in thymidine-kinase activity may be the result of a qualitative alteration in the enzyme molecule. This is reflected in the apparent alteration in the sensitivity of the enzyme to trifluorothymidine. It is suggested that this relationship between the galactokinase and thymidine kinase is not fortuitous but a reflection of their interdependence as found previously in the Chinese hamster.
D000483:Alleles; D002460:Cell Line; D003470:Culture Media; D005347:Fibroblasts / Q000166:cytology / Q000201:enzymology; D005686:Galactokinase / Q000172:deficiency* / Q000235:genetics; D008040:Genetic Linkage; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D013937:Thymidine Kinase / Q000172:deficiency* / Q000235:genetics
D003470:Culture Media; D013937:Thymidine Kinase; D005686:Galactokinase