Effect of caffeine on induced damage in cells of Xenopus laevis.
Xenopus laevis cells were treated with mitomycin C and subsequently treated with caffeine during either the S- or G2-phase of the cell cycle. The frequency of induced chromatid exchanges was especially increased by caffeine posttreatment during the S-phase. This increase took place at the expense of the frequency of isochromatid breaks, which was reduced, both when the caffeine posttreatment was given during the S- and G2-phase.
D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D002460:Cell Line; D002869:Chromosome Aberrations; D003043:Cocarcinogenesis; D004357:Drug Synergism; D008937:Mitomycins / Q000494:pharmacology; D014982:Xenopus laevis
D008937:Mitomycins; D002110:Caffeine