Electrocardiographic and echocardiographic changes after one to two-years' treatment of hypertension. Analyses of voltages (Sv1+RV5), wall thickness, cavity, mass, and hemodynamics of the left ventricle.
The changes of left ventricular anatomy and function following treatment with antihypertensive agents for 1 to 2 years were studied by echo-cardiography in 34 patients with hypertension whose blood pressures and electrocardiographic voltages (SV1+RV5) were significantly decreased (p less than 0.001 and 0.01, respectively). The drugs administered or used were trichlormethiazide, beta-blockers, alpha-methyldopa, clonidine hydrochloride, and guanethidine. Most patients received 2 or more of the above drugs. The interventricular septal thickness, the left ventricular posterior wall thickness, the calculated left ventricular mass, the atrial dimensions, all decreased following treatment of hypertension for 1 to 2 years (p less than 0.001-0.05), and the ejection fraction improved (p less than 0.001). It is concluded that cardiac hypertrophy is not irreversible in patients with hypertension if their blood pressure is adequately controlled.
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001794:Blood Pressure; D006332:Cardiomegaly / Q000188:drug therapy; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D006439:Hemodynamics; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology
D000959:Antihypertensive Agents