Ibuprofen in experimental vascular surgery.
Animal studies have been conducted to determine the effectiveness of ibuprofen in reducing early platelet deposition on small diameter (4 mm) Gore-Tex (polytetrafluoroethylene) arterial grafts and larger (10 mm) Gore-Tex grafts placed in the inferior vena cava. These studies demonstrated a significant reduction in platelet deposition at one and three hours. Additional studies of animals undergoing treatment with ibuprofen and subjected to arterial replacement with 1 or 4 mm Gore-Tex grafts demonstrated enhanced patency at 30 days. Cautious evaluation of ibuprofen as an adjunct in vascular surgery appears warranted.
D000818:Animals; D001012:Aorta, Abdominal / Q000601:surgery; D001807:Blood Vessel Prosthesis; D004285:Dogs; D005263:Femoral Artery / Q000601:surgery; D007052:Ibuprofen / Q000627:therapeutic use*; D007204:Indium; D008855:Microscopy, Electron, Scanning; D010974:Platelet Aggregation / Q000187:drug effects*; D011138:Polytetrafluoroethylene; D011292:Premedication; D011868:Radioisotopes; D051381:Rats; D013997:Time Factors; D014682:Vena Cava, Inferior / Q000601:surgery
D011868:Radioisotopes; D007204:Indium; D011138:Polytetrafluoroethylene; D007052:Ibuprofen