Actions of cysteinyl leukotrienes in coronary, femoral and carotid vessels of the pig.
Coronary, femoral and carotid vascular beds of anaesthetised pigs were perfused with heparinised arterial blood using an extracorporeal perfusion system. Blood flow was measured in each vascular bed. Leukotriene (LT) D4 caused a dose-related reduction in flow in the left anterior descending (LAD) artery. LTs C4 and D4, angiotensin and noradrenaline caused dose-related reductions in flow in femoral and carotid vascular beds. High doses of LTD4 caused total cessation of blood flow in the LAD and femoral beds. In the femoral and carotid beds LTC4 but not LTD4 caused an initial increase followed by a prolonged reduction in flow. Indomethacin (1.4 X 10(-5) mol kg-1, i.v.) did not affect the vasoconstrictor action of LTs.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D002339:Carotid Arteries / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects*; D005260:Female; D005263:Femoral Artery / Q000187:drug effects*; D006614:Hindlimb / Q000098:blood supply; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D013189:SRS-A / Q000494:pharmacology*; D013552:Swine
D013189:SRS-A; D000804:Angiotensin II; D009638:Norepinephrine; D007213:Indomethacin