[Comparative analysis of the proportion of genetic and environmental factors in the development of epilepsy].
With the help of genetic-dispersion analysis the authors studied a series of phenotypes, using both their own familial records (232 families, 5060 relatives of the I-III degree of kinship) as well as those of other researchers (570 families, 18415 relatives of the I-III degree of kinship). The results have shown that the contribution of the genetic and environmental factors to the determination of epilepsy constitutes 5% and 95% in the alternative phenotype model and 65% and 35% in the quasi-continuous phenotype model, respectively. The degree of the genetic factors involvement in the development of phenotypes of "genuine" and "centroencephalic" epilepsy increases irrespective of the phenotype model. The authors also present their outlook on further developments of the genetic dispersion analysis in the research of multifactorial mental diseases.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008905:Minicomputers; D008957:Models, Genetic; D010641:Phenotype; D012640:Seizures / Q000235:genetics
Sravnitel'nyĭ analiz udel'nogo vesa geneticheskikh i sredovykh faktorov v razvitii épilepsii.