Fructose 2,6-bisphosphate, the probably structure of the glucose- and glucagon-sensitive stimulator of phosphofructokinase.
The low-molecular-weight stimulator of phosphofructokinase [Van Schaftingen, Hue & Hers (1980) Biochem. J. 192, 887-895] has been purified from rat liver. It was completely destroyed upon incubation with 0.01 M-HCl for 10 min at 20 degrees C and fructose 6-phosphate and a reducing power equivalent in amount to the acid-labile organic phosphate were formed. It was therefore tentatively identified as fructose 2,6-bisphosphate.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002852:Chromatography, Ion Exchange; D005635:Fructosediphosphates / Q000302:isolation & purification* / Q000494:pharmacology; D005934:Glucagon / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology*; D006598:Hexosediphosphates / Q000302:isolation & purification*; D066298:In Vitro Techniques; D008099:Liver / Q000032:analysis* / Q000187:drug effects / Q000201:enzymology; D008297:Male; D010732:Phosphofructokinase-1 / Q000378:metabolism*; D051381:Rats; D013268:Stimulation, Chemical
D005635:Fructosediphosphates; D006598:Hexosediphosphates; D005934:Glucagon; D010732:Phosphofructokinase-1; D005947:Glucose