2,3-Bisphosphoglycerate inhibits the transport of phosphoenolpyruvate across the erythrocyte membrane.
Mono- and bisphosphoglycerate competitively inhibited the transport of phosphoenolpyruvate across the erythrocyte membrane, although phosphoglycerates were impermeable to the cell membrane. The Ki values of 2-phosphoglycerate, 3-phosphoglycerate and 2,3-bisphosphoglycerate were 8.8 mM, 10.4 mM and 4.3 mM, respectively, whereas glucose 6-phosphate had almost no effect on the transport of phosphoenolpyruvate.
D019794:2,3-Diphosphoglycerate; D001692:Biological Transport / Q000187:drug effects; D004163:Diphosphoglyceric Acids / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D005988:Glyceric Acids / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D010728:Phosphoenolpyruvate / Q000097:blood*
D004163:Diphosphoglyceric Acids; D005988:Glyceric Acids; D019794:2,3-Diphosphoglycerate; C008885:2-phosphoglycerate; D010728:Phosphoenolpyruvate; C005156:3-phosphoglycerate