Interleukin 2, production in the syngeneic mixed lymphocyte reaction.
In the syngeneic mixed lymphocyte reaction, Ly 1 cells proliferate following stimulation with Ia-positive macrophage-like cells. The proliferation is accompanied by the release of interleukin 2 into the medium. Both the proliferation and interleukin 2 production are dependent on the expression of Ia antigenic determinants, as the addition of haplotype-specific anti-Ia antisera to the cultures inhibits both parameters.
D000818:Animals; D000918:Antibody Specificity; D002448:Cell Adhesion; D003165:Complement System Proteins; D006238:Haploidy; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007106:Immune Sera / Q000494:pharmacology; D007376:Interleukin-2 / Q000096:biosynthesis*; D007519:Isoantigens / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D008222:Lymphokines / Q000096:biosynthesis*; D051379:Mice; D008808:Mice, Inbred CBA; D010586:Phagocytes / Q000276:immunology
D000949:Histocompatibility Antigens Class II; D007106:Immune Sera; D007376:Interleukin-2; D007519:Isoantigens; D008222:Lymphokines; D003165:Complement System Proteins