Synergistic antileukemic activity of combinations of two nitrosoureas.
A rationale based on known chemical, biochemical, and biologic properties of nitrosoureas led to the testing of combinations of CCNU with chlorozotocin for in vivo activity against L1210 leukemia. Several combinations yielded synergistic antileukemic activity.
D000818:Animals; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D007274:Injections, Intraperitoneal; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000473:pathology; D008130:Lomustine / Q000008:administration & dosage* / Q000633:toxicity; D051379:Mice; D009368:Neoplasm Transplantation; D009607:Nitrosourea Compounds / Q000008:administration & dosage*; D013311:Streptozocin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D013997:Time Factors
D009607:Nitrosourea Compounds; C007028:chlorozotocin; D013311:Streptozocin; D008130:Lomustine