Protective effect of epomediol on calcium release induced by palmitoyl CoA in the sarcoplasmic reticulum.
Epomediol, used at 1 mM concentration, does not modify the calcium movements in the sarcoplasmic reticulum vesicles. Nevertheless it reduces by about 35% the calcium release induced by 30 microM palmitoyl CoA. This effect can be attributed to the stabilizing action of epomediol on the sarcoplasmic reticulum membrane.
D000214:Acyl Coenzyme A / Q000494:pharmacology*; D000818:Animals; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002118:Calcium / Q000378:metabolism*; D002756:Cholagogues and Choleretics / Q000494:pharmacology*; D066298:In Vitro Techniques; D010171:Palmitoyl Coenzyme A / Q000494:pharmacology*; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000187:drug effects* / Q000378:metabolism; D013729:Terpenes / Q000494:pharmacology*
D000214:Acyl Coenzyme A; D019086:Bridged Bicyclo Compounds, Heterocyclic; D002756:Cholagogues and Choleretics; D013729:Terpenes; D010171:Palmitoyl Coenzyme A; C031365:epomediol; D002118:Calcium