Effect of norepinephrine and vasopressin on carotid sinus baroreceptor activity in the anesthetized rabbit.
Norepinephrine (NE) 10(-6) M or vasopressin (VP) 12.5 microU/ml were injected into the isolated carotid sinus of anesthetized rabbits. The sinus was exposed either to the arterial pressure or to a pressure controlled reservoir. Multifiber and single fiber recordings were made. Both NE and VP increased baroreceptor activity at all sinus pressures but decreased activity in a few fibers. The results are consistent with the drugs having their effects on smooth muscle fibers in the adventitia.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001794:Blood Pressure; D002346:Carotid Sinus / Q000294:innervation*; D009638:Norepinephrine / Q000494:pharmacology*; D011311:Pressoreceptors / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits; D014667:Vasopressins / Q000494:pharmacology*
D014667:Vasopressins; D009638:Norepinephrine