Nuclear localization and DNA binding properties of a protein expressed by human c-myc oncogene.
Antisera to the human cellular myc oncogene product were used to identify a human c-myc specific protein with a molecular weight of 65,000. Subcellular fractionation showed that the human c-myc protein is predominantly found in the cell nucleus. The p65Kc-myc protein binds to double- and single-stranded DNA as measured by a DNA affinity chromatography assay.
D001483:Base Sequence; D002467:Cell Nucleus / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D002846:Chromatography, Affinity; D004273:DNA, Neoplasm / Q000378:metabolism*; D006801:Humans; D009363:Neoplasm Proteins / Q000378:metabolism*; D009857:Oncogenes; D012333:RNA, Messenger / Q000378:metabolism; D013347:Subcellular Fractions / Q000378:metabolism
D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D012333:RNA, Messenger