[Combined antiviral effect of synthetic polyribonucleotide interferonogens and specific antiviral antibodies in arbovirus infections].
A model of tick-borne encephalitis in BALB/c mice was used to investigate the protective anti-viral effect of an interferon inducer, poly(G).poly(C), and specific gamma-globulin administered to the animals together or separately in small doses 24 hours before or after virus inoculation. Administration to the animals of poly(G).poly(C) alone or gamma-globulin alone was shown to produce a poor protective effect. Simultaneous administration of both preparations resulted in a significant decrease of mouse mortality after infection. As a result of the pretreatment of chick embryo cell cultures with poly(G).poly(C) before inoculation and the addition of specific immune serum to the agar overlay after the Sindbis virus inoculation, its multiplication was inhibited much more than after treatment of the cells with interferon inducer alone or antibody alone. Possible mechanisms of the observed additive antiviral effects of the interferon inducer and antibody, including those associated with the influence on the virus-induced interferon production, as well as the possibility of their combined use for the prevention and treatment of viral infections are discussed.
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D000918:Antibody Specificity; D000998:Antiviral Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004675:Encephalitis, Tick-Borne / Q000276:immunology / Q000628:therapy*; D007116:Immunization, Passive; D007369:Interferon Inducers / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D011066:Poly C / Q000627:therapeutic use; D011068:Poly G / Q000627:therapeutic use; D011131:Polyribonucleotides / Q000627:therapeutic use*
D000914:Antibodies, Viral; D000998:Antiviral Agents; D007369:Interferon Inducers; D011131:Polyribonucleotides; D011068:Poly G; C008961:poly G-poly C; D011066:Poly C
Kombinirovannyĭ protivovirusnyĭ éffekt sinteticheskikh poliribonukleotidnykh interferonogenov i spetsificheskikh protivovirusnykh antitel pri arbovirusnykh infektsiiakh.