Piperazinylquinoxalines with central serotoninmimetic activity.
Regioselective syntheses of substituted 2-chloroquinoxalines and derived 2-(1-piperazinyl)quinoxalines are described. Selectivity in regards to serotonin reuptake blocking and serotoninmimetic activities of the piperazinylquinoxalines is reported. In general, introduction of a 6-substituent into the piperazinylquinoxaline enhanced serotonin reuptake blocking activity and diminished serotoninmimetic activity. Unsubstituted and 3-hydroxypiperazinylquinoxalines had primarily serotoninmimetic activity.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors; D009474:Neurons / Q000378:metabolism; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000502:physiology*
D010879:Piperazines; D011810:Quinoxalines; D012701:Serotonin; D008694:Methamphetamine