[Ultrastructural and microanalytic study of gold depots in the synovial membrane of man and animals during treatment with sodium aurothiopropanol sulfonate].
In inflammatory rheumatism treated by gold therapy synoviocytes A are stuffed with gold salt deposits leading to a therapeutic thesaurismosis. These deposits are localized in lysosomes, then called aurosomes. However they may be rarely near collagen fibers or free, particularly in ankylosing spondylitis synovitis. Their structural morphological aspect is the same in several human rheumatic diseases and in rabbit experimental arthritis whatever the gold salt used. In such deposits, microprobe analysis shows gold and sulphur. This latter is probably given by the cell. Therapeutic effect of gold salts may imply the effect of the thiol moiety and the gold metal one.
D000328:Adult; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000473:pathology; D004112:Dimercaprol / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D005260:Female; D006046:Gold / Q000032:analysis* / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D050607:Organogold Compounds; D009942:Organometallic Compounds; D020005:Propanols; D011817:Rabbits; D013438:Sulfhydryl Compounds; D013583:Synovial Membrane / Q000032:analysis* / Q000648:ultrastructure
D050607:Organogold Compounds; D009942:Organometallic Compounds; D020005:Propanols; D013438:Sulfhydryl Compounds; D004112:Dimercaprol; D006046:Gold; C013394:aurotioprol
Etude ultrastructurale et microanalyse des dépôts d'or dans la membrane synoviale chez l'homme et chez l'animal au cours des traitements par l'aurothiopropanol-sulfonate de sodium.