Typing for RhLA-D in rhesus monkeys: I. Characteristics of ten groups of homozygous typing cells.
Certain characteristics of 38 homozygous typing cell (TC's) of rhesus monkeys were determined. These TC's define ten RhLA-D locus specificities. Eight of them are associated with established RhLA-DR antigens. Two other groups of typing cells, D9 and D10, were previously considered to be associated with "blank" antigens of the DR series; they now appear to be associated with B-cell antigens which are also likely to be controlled by the DR locus. No influence of RhLA-A or B antigens of MLC reactivity was observed. It was shown, however, that products of at least one locus other than D/DR is responsible for MLC stimulation. Whether those MLC antigens are associated with serologically identifiable B-cell antigens which are not controlled by the DR locus, is not yet clear.
D000818:Animals; D005260:Female; D006649:Histocompatibility Antigens / Q000235:genetics; D006650:Histocompatibility Testing; D006720:Homozygote; D007959:Lymphocyte Culture Test, Mixed; D008251:Macaca / Q000276:immunology*; D008253:Macaca mulatta / Q000276:immunology*; D008297:Male
D006649:Histocompatibility Antigens