Statistical analysis of the micronucleus test.
Various statistical procedures are discussed to compare the incidence of micronucleated polychromatic erythrocytes between various treatment groups and a negative control. The effect of toxicity on the choice of statistical procedure is discussed. The procedure which is recommended is based on likelihood ratio tests comparing each dose group separately against the negative control. The significance level is controlled to allow for the multiple comparisons.
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects*; D003520:Cyclophosphamide / Q000633:toxicity*; D004912:Erythrocytes / Q000187:drug effects*; D007854:Lead / Q000633:toxicity*; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens; D009942:Organometallic Compounds; D013223:Statistics as Topic
D009153:Mutagens; D009942:Organometallic Compounds; D007854:Lead; D003520:Cyclophosphamide; C008261:lead acetate