[Anticancer drug sensitivity tested by tumor stem cell assay].
Accurate in vitro anticancer drug sensitivity is helpful for successful chemotherapy of cancer patients. The purpose of the present study was to evaluate the tumor stem cell assay for the selection of effective drugs for individual patients with cancer and for the in vitro phase II screening of new anticancer drugs. Sixty-six specimens obtained from cancer patients were tested drug sensitivity by this assay. The results showed that this assay as an excellent technique for testing in vitro sensitivity of anticancer drugs against tumor cells from specimens removed from individual patients. The in vitro results correlated with in vivo response data in 93% of the instances observed in vitro-in vivo associations and a true negative rate was 100%.
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D003114:Colony-Forming Units Assay; D004351:Drug Resistance; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D013274:Stomach Neoplasms / Q000473:pathology; D014410:Tumor Stem Cell Assay
D000970:Antineoplastic Agents