Primary renal candidiasis in two preterm neonates. Report of cases and review of literature on renal candidiasis in infancy.
Primary renal candidiasis and hydronephrosis were diagnosed in two premature neonates in whom systemic hypertension developed. The clinical course in these patients and in 16 patients with renal candidiasis described in the literature indicated that prematurity, use of broad-spectrum antibiotics, and use of intravenous (IV) catheters are predisposing factors. Anuria and flank mass were the initial manifestations in the reviewed cases. Only four of the 16 patients survived following either antifungal therapy or nephrectomy. Both of our patients survived after antifungal therapy with amphotericin B and flucytosine for systemic effect as well as topical instillation of amphotericin B solution via a nephrostomy. We believe that a high index of suspicion in infants at risk and early institution of antifungal therapy for systemic as well as topical effect can improve the outcome in infants with renal candidiasis.
D000666:Amphotericin B / Q000627:therapeutic use; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D006869:Hydronephrosis / Q000209:etiology; D006973:Hypertension / Q000209:etiology; D007223:Infant; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000382:microbiology*; D007674:Kidney Diseases / Q000150:complications / Q000382:microbiology*; D007682:Kidney Pelvis / Q000382:microbiology; D008297:Male
D000666:Amphotericin B; D005437:Flucytosine