[Neuroradiology of the normal and pathological anatomy of the rat brain. II Microangiographic investigations of the vascularisation of transplanted malignant brain tumors (author's transl)].
70 BD-IX rats, in which chemically induced mixed gliomas have been transplanted intracerebrally, were investigated by microangiography. The pattern and the degree of tumor vascularisation of all animals was correlated with the histological findings. Depended on the type of the tumor different localisations of tumor growth could be found: G XII-gliomas preferred the juxtaventricular region and subarachnoid space whereas GL 2.2-gliomas mainly grew as solid intracerebral space occupying lesions. Microangiograms of all tumor stages from the 14th to 42nd day after transplantation revealed a typical vascular pattern consisting of lacunar, glomerulose and netlike vessels. Further, necrosis, bleedings into the tumor, and irregularities of the capillary network could be demonstrated. The volume, age and vascularisation of the tumors are correlated and the results are discussed with regard to the principles of tumor growth and malignancy.
D000818:Animals; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000098:blood supply* / Q000473:pathology; D002551:Cerebral Ventricle Neoplasms / Q000098:blood supply / Q000473:pathology; D005910:Glioma / Q000098:blood supply* / Q000473:pathology; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000098:blood supply* / Q000473:pathology; D051381:Rats
Neuroradiologie der normalen und pathologischen Anatomie des Rattenhirnes. II. Mikroangiographische Untersuchungen zur Vaskularisation transplantierter maligner.