[Precancerous conditions and carcinomas of the lower lip. Coincidence with leukoplakia and carcinomas of the oral cavity and larynx].
In a prospective study of 102 patients with pre-neoplasia and/or manifest squamous-cell carcinoma of the lower lip the synchronous occurrence of intra-oral, pharyngeal or laryngeal leukoplakia and carcinoma was assessed. There was a coincidence rate of almost 15% leukoplakias, including individual carcinomas. This high coincidence is probably due to a combination of various "risk profiles" in patients with threatened or manifest lower-lip cancer. Chronic exposure to sunlight, especially in the presence of a genetic disposition, is the most important risk factor in lower-lip cancer and its preceding stages, while chronic alcoholism and smoking abuse have little etiological significance.
D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology*; D005260:Female; D005860:Germany, West; D006801:Humans; D007822:Laryngeal Neoplasms / Q000453:epidemiology*; D007972:Leukoplakia, Oral / Q000453:epidemiology*; D008048:Lip Neoplasms / Q000453:epidemiology*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000453:epidemiology*; D009378:Neoplasms, Multiple Primary / Q000453:epidemiology*; D011230:Precancerous Conditions / Q000453:epidemiology*; D011446:Prospective Studies; D012306:Risk
Präkanzerosen und Karzinome der Unterlippe. Koinzidenz mit Leukoplakien und Karzinomen der Mundhöhle und des Kehlkopfes.