Strain differences in testes degeneration, myopathy, and the lymphocyte mitogen response in vitamin E-deficient rats.
The differences in sensitivity to vitamin E deficiency were examined in two genetically related inbred strains of rat, the spontaneously hypertensive rat and its genetic ancestor, the Wistar-Kyoto rat, as well as in the outbred Sprague-Dawley strain. The three strains showed differences in growth rate, myopathy, testes degeneration, and immunological responses in response to vitamin E deficiency with the spontaneously hypertensive rat showing the greatest sensitivity to the deficiency.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008934:Mitogens; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013154:Spleen / Q000187:drug effects; D013737:Testis / Q000187:drug effects / Q000473:pathology*; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives / Q000494:pharmacology; D014811:Vitamin E Deficiency / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D008934:Mitogens; D014810:Vitamin E; D024502:alpha-Tocopherol; D024505:Tocopherols