Hypoglycemic effect of disopyramide in a case of diabetes mellitus under insulin treatment.
In a 41-year-old male with diabetes mellitus well controlled with insulin (50 units/day), hypoglycemia developed after starting disopyramide treatment (200 mg/day) for correction of tachycardia. Lower levels of blood glucose and smaller amounts of urinary sugar persisted until disopyramide was withdrawn even after reducing insulin to a minimum dose of 20 units/day. The insulin requirement increased again thereafter to the original dose. These results indicate that disopyramide had a hypoglycemic effect in this patient.
D000328:Adult; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy; D004206:Disopyramide / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D011725:Pyridines / Q000009:adverse effects*; D013610:Tachycardia / Q000188:drug therapy
D007328:Insulin; D011725:Pyridines; D004206:Disopyramide