Activity of Carbetimer in a human tumor cloning system.
The antitumor activity of Carbetimer was tested against 171 patient's tumors in a human tumor cloning system. Sixty-seven tumor specimens had adequate growth to be considered evaluable. In 21 specimens survival of tumor colony forming units was less than or equal to 50% that in control plates. Antitumor effect was most impressive in carcinomas of the breast, ovary, and lung. This information will be useful in planning disease oriented Phase II trials.
D000970:Antineoplastic Agents / Q000494:pharmacology*; D003114:Colony-Forming Units Assay; D006801:Humans; D011108:Polymers / Q000494:pharmacology*
D000970:Antineoplastic Agents; D011108:Polymers; C022084:carboxyimamidate