Hypoxic radiosensitization by the antimicrobial methyl paraben.
The antimicrobial preservative, methyl paraben (methyl-4-hydroxybenzoate) sensitizes anoxic buffered suspensions of Staphylococcus aureus to gamma-radiation. The maximal response at an 0.5 mM concentration represents a 150 percent increase in response over that for deoxygenated suspensions without additive (E.R. = 2.5), and 80 percent of the response for aerated suspensions alone. Methyl paraben is not toxic to the test organism under the present test conditions.
D003037:Cobalt Radioisotopes; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D010100:Oxygen / Q000502:physiology*; D010226:Parabens / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000528:radiation effects*; D013997:Time Factors
D003037:Cobalt Radioisotopes; D010226:Parabens; D011838:Radiation-Sensitizing Agents; C015358:methylparaben; D010100:Oxygen