Potentiative interactions between caffeine and various teratogenic agents.
Acetazolamide and inhibitors of DNA synthesis (hydroxyurea, 5-fluoro-2'-deoxyuridine), RNA synthesis (actinomycin D), and protein synthesis (cycloheximide, emetine) were each administered to pregnant rats together with caffeine at doses where each agent alone caused minimal embryotoxicity. Caffeine co-administered with any of the other agents induced a powerful potentiative response. It is not clear from the present experiments whether much lower caffeine dosage, as normally encountered in humans, would potentiate embryotoxicity due to other agents.
D000014:Abnormalities, Drug-Induced; D000086:Acetazolamide / Q000633:toxicity; D000818:Animals; D002110:Caffeine / Q000633:toxicity*; D003513:Cycloheximide / Q000633:toxicity; D003609:Dactinomycin / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004640:Emetine / Q000633:toxicity; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005467:Floxuridine / Q000633:toxicity; D006918:Hydroxyurea / Q000633:toxicity; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D005467:Floxuridine; D003609:Dactinomycin; D002110:Caffeine; D003513:Cycloheximide; D000086:Acetazolamide; D006918:Hydroxyurea; D004640:Emetine