Amitrole-induced cell transformation and gene mutations in Syrian hamster embryo cells in culture.
Amitrole, a widely used herbicide, is an animal carcinogen and an inducer of cell transformation. However, it is inactive as a mutagen in bacterial test systems. Thus, it has been suggested that amitrole is a non-mutagenic carcinogen. Over the dose range that induces morphological transformation of Syrian hamster embryo cells in culture, amitrole induced gene mutations at the Na+/K+ ATPase and hypoxanthine phosphoribosyl transferase loci measured concomitantly in the same cells. These results indicate that amitrole may act via a mutational mechanism.
D000640:Amitrole / Q000494:pharmacology*; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002478:Cells, Cultured; D006224:Cricetinae; D008647:Mesocricetus; D009154:Mutation / Q000187:drug effects*; D014230:Triazoles / Q000494:pharmacology*
D014230:Triazoles; D000640:Amitrole