H2-receptors in the human ocular surface.
Ten normal human volunteers participated in a two-part study of H2-receptor activity in the ocular surface. Dimethylaminopropylisothiourea (trivial name, dimaprit dihydrochloride), a highly selective H2-receptor agonist, produced vasodilation without itch. Pretreatment with the H2-receptor antagonist, cimetidine, significantly blocked the vasodilatory effect of dimethylaminopropylisothiourea, whereas pretreatment with the H1-receptor antagonist, antazoline phosphate, did not. We conclude that H2-receptors are present in the human ocular surface.
D000865:Antazoline / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D003228:Conjunctiva / Q000032:analysis* / Q000098:blood supply; D017259:Dimaprit; D006801:Humans; D006940:Hyperemia / Q000139:chemically induced; D011968:Receptors, Histamine / Q000032:analysis*; D011970:Receptors, Histamine H2 / Q000032:analysis* / Q000187:drug effects; D013890:Thiourea / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects
D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D002927:Cimetidine; D000865:Antazoline; D013890:Thiourea; D017259:Dimaprit