The effect of 6-amidino-2-naphtyl-4-guanidinobenzoate dimethane sulfonate (FUT-175) on experimental glomerulonephritis in mice.
Effect of 6-amidino-2-naphtyl-4-guanidinobenzoate dimethane sulfonate (FUT-175) on experimental glomerulonephritis in mice was studied. Employed models are nephrotoxic serum (NTS) nephritis in ddY or A/He mice, rabbit IgG (RGG) accelerated NTS nephritis in ddY mice and spontaneous nephritis in (NZB x NZW) F1 mice. The severity of nephritis was evaluated by measuring proteinuria and serological parameters and examining renal tissue by light microscopy. Therapy with FUT-175 clearly prevented the pathological changes of proteinuria and serological parameters in all four nephritis models. By contrast, treatment hardly affected histopathological changes of the kidney in any of the models. Cyclophosphamide used as a comparative drug showed more clearly remission of the onset and development of NTS nephritis and RGG accelerated NTS nephritis in ddY mice by means of the changes of urinary and selorogical parameters. These evidences suggest that FUT-175 shows beneficial effects on the nephritis in either normal or complement deficient mice.
D000818:Animals; D001550:Benzamidines; D003169:Complement Inactivator Proteins / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004195:Disease Models, Animal; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000473:pathology; D006146:Guanidines / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D009393:Nephritis / Q000139:chemically induced / Q000503:physiopathology; D011817:Rabbits
D001550:Benzamidines; D003169:Complement Inactivator Proteins; D006146:Guanidines; D003520:Cyclophosphamide; C032855:nafamostat