[Effect of kynurenines on the actions of acetylcholine, oxotremorine, and nicotine].
Kynurenine, 3-hydroxyanthranilic, anthranilic and nicotinic acids at concentrations 10(-4) and 10(-5) M potentiated contractions of the isolated rat rectum produced by acetylcholine. Contractile response of the phrenico-diaphragmatic preparation of young rats to acetylcholine was diminished by kynurenine, 3-hydroxykynurenine and by quinolinic acid. In rats of both sexes, 3-hydroxyanthranilic, anthranilic, picolinic and nicotinic acids in doses of 10 and 20 mg/kg shortened the latency of oxotremorine tremor. Quinolinic and nicotinic acids reduced the latency of nicotinic tremor and potentiated hypothermia.
D015095:3-Hydroxyanthranilic Acid / Q000008:administration & dosage; D000109:Acetylcholine / Q000008:administration & dosage*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D007737:Kynurenine / Q000008:administration & dosage* / Q000031:analogs & derivatives; D008297:Male; D009469:Neuromuscular Junction / Q000187:drug effects; D009525:Niacin; D009538:Nicotine / Q000008:administration & dosage*; D009539:Nicotinic Acids / Q000008:administration & dosage; D010095:Oxotremorine / Q000008:administration & dosage*; D010848:Picolinic Acids / Q000008:administration & dosage; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000008:administration & dosage; D051381:Rats; D062367:ortho-Aminobenzoates / Q000008:administration & dosage
D009539:Nicotinic Acids; D010848:Picolinic Acids; D011805:Quinolinic Acids; D062367:ortho-Aminobenzoates; C031385:anthranilic acid; D015095:3-Hydroxyanthranilic Acid; D009525:Niacin; C005045:3-hydroxykynurenine; D007737:Kynurenine; D010095:Oxotremorine; D009538:Nicotine; D017378:Quinolinic Acid; D000109:Acetylcholine; C030614:picolinic acid
Vliianie kinureninov na éffekty atsetilkholina, oksotremorina i nikotina.