Thermal model for ultrasonic treatment of glaucoma.
Focused ultrasound, at a frequency of 4.6 MHz, was used to create lesions of the sclera in the proptosed glaucomatous eye of the anesthetized albino rabbit, with the result that elevated intra-ocular pressures were reduced to normal levels. Initial trials on carefully selected glaucoma patients have also shown that pressure reductions can be produced with high-intensity ultrasound. A theoretical model was developed to compute the spatio-temporal features of temperature rises induced in the sclera during these treatments. Experimental data confirmed the accuracy of the model.
D000818:Animals; D001831:Body Temperature; D005901:Glaucoma / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D007429:Intraocular Pressure; D008954:Models, Biological; D011817:Rabbits; D012590:Sclera / Q000503:physiopathology; D013997:Time Factors; D014464:Ultrasonic Therapy