[Studies on influence of thiocyanate on immune response by use of the hemolytic plaque technique (author's transl)].
Mice immunized with sheep red blood cells produce more direct plaque-forming cells, estimated with the hemolytic plaque-technique, during the primary immune response if they receive in that time 150 mg NaSCN/kg body mass with the drinking-water every day. The thiocyanate quantity of serum in immunized animals is higher than that in non-immunized animals. The titers of antibodies estimated by the hemagglutination test is about 1 titer step higher in thiocyanate-treated animals than in non-thiocyanate-treated animals. That applies also to the secondary immune response, in which course thiocyanate was not supplied. It is possible, that for instance a greater number of memory-cells was produced during the primary immune response in consequence of the thiocyanate application. Studies in similar arrangement with guinea-pigs confirm these statements in certain parameters.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects; D004912:Erythrocytes / Q000276:immunology; D006168:Guinea Pigs; D006462:Hemolytic Plaque Technique; D007117:Immunization, Secondary; D051379:Mice; D013861:Thiocyanates / Q000494:pharmacology*
D013861:Thiocyanates
Untersuchungen zum Einfluss von Thiocyanat auf die Immunantwort mit der direkten Hämolyse-Plaque-Technik.