Platelet-derived growth factor stimulates chemotaxis and nucleic acid synthesis in the protozoan Tetrahymena.
Platelet-derived growth factor (PDGF) is in concentrations of a few nanograms per ml a very active chemoattractant for the free-living ciliated protozoan Tetrahymena; at the same time it induces a rapid increase in incorporation of radioactive nucleic acid precursors into RNA and DNA. We find it remarkable that this lower eukaryote responds to platelet-derived growth factor in very much the same way as fibroblastic cells.
D000818:Animals; D002633:Chemotaxis / Q000187:drug effects*; D004261:DNA Replication / Q000187:drug effects*; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D013768:Tetrahymena / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D013936:Thymidine / Q000378:metabolism; D014158:Transcription, Genetic / Q000187:drug effects*; D014529:Uridine / Q000378:metabolism
D010982:Platelet-Derived Growth Factor; D013936:Thymidine; D014529:Uridine