[Preferential segregation of chromosome 21p- in 3 generations. Ultimate role in non-disjunction (apropos of a case of trisomy 21 in this family)].
A chromosome 21p- was observed in double dose in a trisomic 21 patient; the mother and other members of her family, in three generations, were carriers of this marker chromosome. After the analysis of similar families reported in the literature, the possible role of this marker in non disjunction and its segregation during meiosis is discussed.
D000328:Adult; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D002904:Chromosomes, Human, 21-22 and Y; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D005819:Genetic Markers; D006801:Humans; D007231:Infant, Newborn; D008297:Male
D005819:Genetic Markers
Segrégation préférentielle d'un chromosome 21p- dans trois générations. Rôle éventuel dans la non-disjonction (à propos d'un cas de trisomie 21 dans cette famille).