[Hepatic artery of the rat in experimental cirrhosis of the liver].
In 30 male rats of Wistar strain (20 more rats served as controls) thickness of the internal elastic membrane, that of the media, cross section area of the media and that of the lumen were define 3, 4, 5 and 6 months after the experiment was started. The initial changes in the hepatic artery structure are noted on the 4th month, however, differences in the parameters are not yet statistically significant. On the 5th month certain signs of hypertrophy in the smooth muscle cells of the media are clearly seen, as well as an increasing thickness of the internal elastic membrane and that of the tunica media. Simultaneously, the index of labelling the myocyte nuclei reaches its maximum. The increasing thickness of the arterial wall causes certain decrease in the lumen cross section area. The changes of all the parameters are statistically significant. In 6 months after the beginning of the experiment, a pronounced hyperelastosis develops in the wall of the hepatic artery; a part of the smooth muscle cells in the tunica media undergoes atrophy. The area of the vascular lumen decreases by 16%, comparing to the age control. The experimental data confirm certain clinical observations and reveal some features in the mechanism of pathological changes occurring in the hepatic artery wall at cirrhosis.
D000818:Animals; D001345:Autoradiography; D004247:DNA / Q000096:biosynthesis; D006499:Hepatic Artery / Q000473:pathology* / Q000648:ultrastructure; D008106:Liver Cirrhosis, Experimental / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013936:Thymidine / Q000378:metabolism
D004247:DNA; D013936:Thymidine
Pechenochnaia arteriia krysy pri éksperimental'noĭ tsirroze pecheni.