[The penetration of moxalactam into bone (author's transl)].
After injection of 2 g of moxalactam over 5 minutes in 8 patients with mean age of 71,5 years, serum halflife was found to be T 50% beta = 184 min and the volume of distribution at steady state VDSS = 17,45l, whereas these figures in volunteers with mean age of 22.8 years were T 50% beta = 134 min and VDSS 16,80l respectively. The concentrations in organic bone were 30 to 60 min after injection of 2 g of Moxalactam 19,40 mg/l with a deviation factor of 1,43 and 61 to 120 min after injection 19,08 mg/l with a deviation factor of 1,16. The problems of penetration of antibiotics into bone are discussed. Moxalactam does not penetrate into anorganic bone (hydroxylapatite).
D000368:Aged; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D002511:Cephalosporins / Q000378:metabolism*; D002513:Cephamycins / Q000378:metabolism*; D003201:Computers; D005260:Female; D005269:Femur / Q000378:metabolism*; D006207:Half-Life; D006622:Hip Prosthesis; D006801:Humans; D008297:Male; D009070:Moxalactam
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002513:Cephamycins; D009070:Moxalactam
Zur Frage der Penetration von Moxalactam in den Knochen.