The spondylitis of inflammatory bowel disease. Evidence for a non-HLA linked axial arthropathy.
Of 12 patients with inflammatory bowel disease (IBD) and ankylosing spondylitis (AS) or sacroiliitis (SI), only 4 (32%) had HLA-B27. Family studies revealed 3 B27-negative relatives with AS, 1 with SI, 1 with SI and IBD, and 1 with IBD alone. HLA haplotypes did not segregate with disease. These data suggest a non-HLA linked genetic predisposition to IBD which also confers susceptibility to spondylitis, even in the absence of expression of bowel disease.
D000328:Adult; D001168:Arthritis / Q000150:complications / Q000235:genetics*; D001416:Back Pain / Q000150:complications; D003093:Colitis, Ulcerative / Q000150:complications / Q000235:genetics*; D003424:Crohn Disease / Q000150:complications / Q000235:genetics*; D004198:Disease Susceptibility; D005260:Female; D005838:Genotype; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012446:Sacroiliac Joint; D013167:Spondylitis, Ankylosing / Q000150:complications / Q000235:genetics*
D006680:HLA Antigens