Qualitative changes in saliva composition after short-term administration of imipramine and zimelidine in healthy volunteers.
Ten healthy volunteers participated in a double-blind controlled, randomized, cross-over trial, where the effects of the antidepressant drugs imipramine (75 mg/day) and zimelidine (100 mg/day and 200 mg/day) on saliva secretion rate and saliva composition were tested. The saliva secretion decreased and qualitative changes were found. Imipramine (75 mg/day) and zimelidine (200 mg/day), but not zimelidine (100 mg/day), increased buffer capacity and the components of the salivary glycoproteins (sialic acid, fucose, hexoses). Total proteins, amylase, secretory component and electrolytes (Na+, K+, Ca++, PO43-) did not change significantly.
D000328:Adult; D001977:Brompheniramine / Q000031:analogs & derivatives / Q000494:pharmacology*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D011725:Pyridines / Q000494:pharmacology*; D011897:Random Allocation; D012463:Saliva / Q000032:analysis / Q000187:drug effects*; D012472:Salivation / Q000187:drug effects; D015031:Zimeldine
D011725:Pyridines; D015031:Zimeldine; D001977:Brompheniramine; D007099:Imipramine