Myoclonus in Down's syndrome. Association with alzheimer's disease.
Myoclonus and progressive intellectual deterioration developed in a 46-year-old woman with trisomy 21 (Down's syndrome) during the final stages of her illness. Her condition was clinically diagnosed as Creutzfeldt-Jakob disease, but necropsy demonstrated the changes characteristic of Alzheimer's disease and cerebrovascular amyloidosis.
D000544:Alzheimer Disease / Q000150:complications* / Q000473:pathology; D001921:Brain / Q000473:pathology; D003704:Dementia / Q000150:complications*; D004314:Down Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009207:Myoclonus / Q000150:complications* / Q000473:pathology