Preliminary model for streptozocin metabolism in mice.
A mathematical model for streptozocin metabolism in mice is presented. By using the available bioassay and chemical assay data for a 300-mg/kg ip injection and the principles of physiologically based pharmacokinetics, a membrane-limited transport model with first-order kinetics was found to simulate the data adequately (average error of less than 20%). Furthermore, the first-order reaction constant derived in analyzing the bioassay data (0.009 min-1) was in close agreement with the half-life of streptozocin (1 hr) reported previously.
D000818:Animals; D001693:Biological Transport, Active; D002462:Cell Membrane / Q000378:metabolism; D005110:Extracellular Space / Q000378:metabolism; D007424:Intracellular Fluid / Q000378:metabolism; D007700:Kinetics; D051379:Mice; D008954:Models, Biological; D013311:Streptozocin / Q000097:blood / Q000378:metabolism*; D014018:Tissue Distribution
D013311:Streptozocin