Separation and functional analysis of subpopulations of T cells in the bone marrow of the mouse.
Functional capacities of T-cells precursors have been evaluated by cell culture experiments after fractionation of bone marrow cells from normal and nude mice by 1 g velocity sedimentation. The results indicate that the T-cell precursors in the bone marrow are cycling cells, that T-cell precursors in the bone marrow of nude mice have more limited potentials than those of normal mice, and that both Thy-1.2-positive and Thy-1.2-negative precursors are stimulated by T-cell activators.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001854:Bone Marrow Cells; D002469:Cell Separation; D003208:Concanavalin A / Q000494:pharmacology; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D010835:Phytohemagglutinins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000145:classification* / Q000276:immunology
D000961:Antilymphocyte Serum; D010835:Phytohemagglutinins; D003208:Concanavalin A