Failure of mineral-vitamin supplements to prevent tansy ragwort (Senecio jacobaea) toxicosis in cattle.
The efficacy of 2 mineral-vitamin supplements in preventing or alleviating initial pyrrolizidine alkaloid (PA) toxicosis in cattle was tested. Three groups of calves were fed 1 of the 2 supplements plus tansy ragwort (Senecio jacobaea) containing PA and 2 groups of calves were fed tansy ragwort without the supplement. Toxicity comparisons were based on differences in observed clinical signs, serum enzyme changes, survival time of calves, and histopathologic examination of hepatic tissue. Typical tansy ragwort toxicosis terminating in death developed in all calves. There were no marked differences in responses of the groups of calves. Seemingly, the supplements did not afford protection or alleviate tansy ragwort-related PA toxicosis in calves.
D000818:Animals; D001216:Asparagine / Q000494:pharmacology / Q000627:therapeutic use; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000209:etiology / Q000517:prevention & control*; D003035:Cobalt / Q000494:pharmacology / Q000627:therapeutic use; D003300:Copper / Q000494:pharmacology / Q000627:therapeutic use; D003545:Cysteine / Q000494:pharmacology; D004338:Drug Combinations; D008903:Minerals / Q000008:administration & dosage / Q000627:therapeutic use*; D009536:Niacinamide / Q000494:pharmacology / Q000627:therapeutic use; D010939:Plant Poisoning / Q000188:drug therapy / Q000662:veterinary*; D010947:Plants, Toxic; D011763:Pyrrolizidine Alkaloids / Q000506:poisoning*; D012674:Senecio; D014815:Vitamins / Q000008:administration & dosage / Q000627:therapeutic use*
D004338:Drug Combinations; D008903:Minerals; D011763:Pyrrolizidine Alkaloids; D014815:Vitamins; D009536:Niacinamide; D003035:Cobalt; D001216:Asparagine; D003300:Copper; D003545:Cysteine