The effect of nonspecific immune stimulation with Corynebacterium parvum and polidin on the Ehrlich ascites tumor growth.
Investigations were performed: a) to compare the effect of two nonspecific immunostimulants, Polidin and Corynebacterium parvum, on the development of Ehrlich ascites carcinoma in mice; b) to determine whether the effects are dependent on the tumor cell dose inoculated into the animals. C. parvum and Polidin administered prior to Ehrlich ascites tumor inoculation have a protective effect evidenced by a delay in tumor development, a retardation in tumor growth and a prolonged survival of the tumor host. The effect of immunostimulants was highly dependent on the tumor cell dose inoculated into mice and was more marked with C. parvum.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use; D000818:Animals; D001561:Benzilates / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000517:prevention & control*; D005260:Female; D007114:Immunization; D051379:Mice; D009368:Neoplasm Transplantation; D011425:Propionibacterium acnes / Q000276:immunology*
D000276:Adjuvants, Immunologic; D001561:Benzilates; C100295:poldine