[Blood fibronectin level in experimental burn shock].
The blood fibronectin concentration in rats was measured by the ELISA during burn shock. Fifteen minutes after burn the fibronectin level was found to drop by 30% of the initial level on the average. Deep hypofibronectinemis lasted up to 24 h after burn. At the same time the clinical and pathomorphological picture of the shock was fairly pronounced. The survived animals demonstrated a progressive normalization of the fibronectin level. The fibronectin level completely returned to normal by the outcome of the second day after burn and then progressed to reactive hyperfibronectinemia by 70-72 h. The data obtained point to the involvement of fibronectin into the pathogenesis of burn shock, which is likely to be connected with the mechanism of reticuloendothelial system dysfunction.
D000818:Animals; D002056:Burns / Q000150:complications*; D005353:Fibronectins / Q000097:blood*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012774:Shock, Traumatic / Q000097:blood*
D005353:Fibronectins
Uroven' fibronektina v krovi pri èksperimental'nom ozhogovom shoke.