Deposits of immunoglobulins and C3 in the walls of human renal arteries.
Ninety-one renal biopsies were examined by immunofluorescent staining for the presence of C3 and immunoglobulins in the walls of renal arteries (RAW), tubules and glomeruli. The diseases studied were non-systemic renal immune complex diseases, systemic diseases with kidney involvement, renal diseases with minimal pathological changes and histological normal kidneys. In a high percentage of cases C3 and, to a lesser degree, deposits of immunoglobulins were found in the RAW, the deposits being found both in immunological and non-immunological diseases. Deposits of C3 but not of C4, C1q, fibrinogen, and immunoglobulins were found in the RAW of 11 normal kidneys examined.
D003928:Diabetic Nephropathies / Q000276:immunology; D005455:Fluorescent Antibody Technique; D005921:Glomerulonephritis / Q000276:immunology; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology; D007136:Immunoglobulins / Q000032:analysis*; D007678:Kidney Glomerulus / Q000032:analysis; D007684:Kidney Tubules / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D009393:Nephritis / Q000276:immunology; D012077:Renal Artery / Q000032:analysis / Q000276:immunology*
D007136:Immunoglobulins