Imaging of platelets in right-sided extracardiac conduits in humans.
As a connection between the systemic venous ventricle and the pulmonary artery, valved Dacron extracardiac conduits have remarkably influenced the surgical approach to many complex congenital heart defects. Obstruction of the conduit, however, can reduce the long-term effectiveness of this corrective procedure. In addition to stenosis of the porcine valve, formation of thick fibrous neointima plays a major role in the pathogenesis of conduit obstruction. The purpose of this study was to determine whether platelet deposition could be demonstrated in these conduits by external imaging with In-111-labeled autologous platelets. After injection of labeled platelets either immediately after operation or on the fifth to eighth postoperative day, imaging was performed by standard procedures. Eight of nine patients had platelet accumulation in the conduit, and treatment with aspirin and dipyridamole caused no recognizable change in platelet deposition. This study demonstrates the feasibility of imaging platelet deposition in Dacron conduits and shows that the pattern of deposition varies with time.
D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects; D001807:Blood Vessel Prosthesis / Q000009:adverse effects*; D002648:Child; D004176:Dipyridamole / Q000627:therapeutic use; D005069:Evaluation Studies as Topic; D005260:Female; D006330:Heart Defects, Congenital / Q000097:blood / Q000000981:diagnostic imaging* / Q000601:surgery; D006350:Heart Valve Prosthesis / Q000009:adverse effects; D006801:Humans; D007204:Indium; D008297:Male; D011093:Polyethylene Terephthalates; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013997:Time Factors
D011093:Polyethylene Terephthalates; D011868:Radioisotopes; D007204:Indium; D004176:Dipyridamole; D001241:Aspirin