Naloxone reduces abdominal muscle tone in mice and rats.
The effect of naloxone on muscle tone was investigated in mice and rats at various times after administration. The naloxone effect was also tested in diazepam-pretreated animals. Naloxone was found to display muscle relaxant activity. This effect appeared to be additive to that of diazepam.
D000009:Abdominal Muscles / Q000187:drug effects*; D000818:Animals; D003975:Diazepam / Q000494:pharmacology; D004347:Drug Interactions; D007700:Kinetics; D008297:Male; D051379:Mice; D009129:Muscle Tonus / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009270:Naloxone; D003975:Diazepam