[123-I-labeled fatty acids for myocardial functional diagnosis].
For 17-123I-heptadecanoic acid (IHA) and 15-(para-123I-phenyl)-pentadecanoic acid (IPPA) the biochemical and pharmacokinetic results show a physiological behaviour similar to the normally occurring fatty acids. For the nuclear medical application both 123I-fatty acids are very well suited; they are fast and efficiently accumulated in the myocardium and, keeping the patient at rest, they allow to record scintigrams of the myocardium with a quality which is obtained with thallium 201 only under stress conditions of the patient. By sequential registration of the scintigrams time activity curves can be generated reflecting the regional in-vivo turnover of fatty acids in the myocardium. Thus in a non-invasive way it is possible to obtain differential informations of the myocardial function in-vivo.
D000818:Animals; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D005227:Fatty Acids / Q000378:metabolism; D006321:Heart / Q000000981:diagnostic imaging*; D006334:Heart Function Tests / Q000379:methods; D006801:Humans; D007457:Iodine Radioisotopes / Q000378:metabolism; D007700:Kinetics; D009206:Myocardium / Q000378:metabolism; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013793:Thallium; D013997:Time Factors
D005227:Fatty Acids; D007457:Iodine Radioisotopes; D011868:Radioisotopes; C027252:17-iodoheptadecanoic acid; D013793:Thallium
123-J-Markierte Fettsäuren für die Funktionsdiagnostik des Myokards.