Inhibition of pig kidney dopa decarboxylase by coenzyme-5-hydroxytryptophan adducts.
The effect of N-(5'-phosphopyridoxyl)-L-5-hydroxytryptophan, N-(5'-phosphopyridoxyl)-D-5-hydroxytryptophan and N-(5'-phosphopyridoxyl)-5-hydroxytryptamine on the reactivation of apoDopa decarboxylase to holoenzyme has been investigated. The different degree of inhibition exerted by these adducts has been interpreted on the basis of a different orientation of the 2 isomers of 5-HTP at the active of Dopa decarboxylase.
D000818:Animals; D001051:Apoenzymes / Q000037:antagonists & inhibitors*; D001059:Apoproteins / Q000037:antagonists & inhibitors*; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D004789:Enzyme Activation / Q000187:drug effects; D004793:Enzyme Reactivators; D007668:Kidney / Q000201:enzymology*; D011732:Pyridoxal Phosphate; D012701:Serotonin / Q000031:analogs & derivatives*; D013552:Swine
D001051:Apoenzymes; D001059:Apoproteins; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D004793:Enzyme Reactivators; D012701:Serotonin; D011732:Pyridoxal Phosphate