[ATPase activity of rat liver mitochondria in acute tetrachloromethane poisoning].
The ATPase activity (proton ATPase) of rat liver mitochondria was studied 2, 24, 28, 96 and 168 h after acute tetrachloromethane poisoning. It is established that the tetrachloromethane poisoning. It is established that the tetrachloromethane poisoning is accompanied by a considerable activation of mitochondrial H+-ATPase and a decrease of the DNP and Ca+, Na+ and K+ activating influence on it. Maximum changes in the H+-ATPase activity is observed 24 h after poisoning. Changes in the H+-ATPase properties are accompanied by a fall in the alpha-ketoglutarate dehydrogenase and succinate dehydrogenase activities and by disturbance of the liver mitochondria contractile properties. The electrochemical membrane potential of the mitochondria under the effect of tetrachloromethane is supposed to be reduced due to a primary damage of the phospholipid matrix of the coupling membrane and an increase in its proton conductivity.
D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology*; D007655:Ketoglutarate Dehydrogenase Complex / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology*; D006180:Proton-Translocating ATPases; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism
D007655:Ketoglutarate Dehydrogenase Complex; D013385:Succinate Dehydrogenase; D000251:Adenosine Triphosphatases; D006180:Proton-Translocating ATPases
ATP-aznaia aktivnost' mitokhondriĭ pecheni krys pri ostrom otravlenni tetrakhlormetanom.