Mutation-induction in repair-deficient strains of Neurospora.
Various mutants sensitive to UV-induced inactivation have been used to study the process of spontaneous and induced mutation in the ad-3 region of Neurospora crassa. Studies on haploid strains have shown that the process of mutation-induction in the ad-3 region is under genetic control. Studies on two-component heterokaryons have shown that this control effects both point mutations and multilocus deletions. Comparisons made between an excision-repair deficient two-component heterokaryon (59) have shown that the level of effect is markedly mutagen-specific. All possible effects on the process of mutation-induction in the ad-3 region have been found in the strains tested.
D000225:Adenine / Q000378:metabolism; D002872:Chromosome Deletion; D005656:Fungal Proteins / Q000378:metabolism; D006238:Haploidy; D006801:Humans; D009153:Mutagens / Q000494:pharmacology; D009154:Mutation; D009491:Neurospora / Q000235:genetics*; D009492:Neurospora crassa / Q000187:drug effects / Q000235:genetics* / Q000528:radiation effects; D014466:Ultraviolet Rays; D014983:Xeroderma Pigmentosum / Q000235:genetics
D005656:Fungal Proteins; D009153:Mutagens; D000225:Adenine