Morphological changes in myofibrils and glycerinated muscle fibers on treatment with cathepsins D and L.
Morphological changes in myofibrils and glycerinated muscle fibers on treatment with cathepsins D and L obtained from rabbit skeletal muscle were studied by phase contrast and electron microscopy. Cathepsin D degraded the Z-line and filaments adjacent to the H-zone. Cathepsin L caused the fragmentation of myofibrils, and degraded the Z-line and M-line. Both cathepsins induced disturbance of the lateral arrangement of myofibrils.
D000818:Animals; D002403:Cathepsins; D005990:Glycerol / Q000494:pharmacology; D008854:Microscopy, Electron; D009132:Muscles / Q000187:drug effects / Q000648:ultrastructure*; D009210:Myofibrils / Q000648:ultrastructure*; D011817:Rabbits
D002403:Cathepsins; D005990:Glycerol