The serum levels of unbound bilirubin that induce changes in some brain mitochondrial reactions in newborn guinea-pigs.
Bilirubin in different concentrations was injected in newborn guinea-pigs and the following parameters were determined: serum total and unbound bilirubin, whole brain bilirubin content and oxygen consumption, NADH-cytochrome c reductase and ATPase activities in brain mitochondria. The results showed a significant correlation between decreased rates of brain metabolism and the elevation of serum total and unbound bilirubin.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001663:Bilirubin / Q000097:blood* / Q000378:metabolism / Q000494:pharmacology; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D006168:Guinea Pigs; D008928:Mitochondria / Q000201:enzymology*; D009245:NADH Dehydrogenase / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects
D009245:NADH Dehydrogenase; D000251:Adenosine Triphosphatases; D001663:Bilirubin