[Combination chemotherapy and radiotherapy. Differential effect, on the medullary syndrome, of fractionated irradiation with fractionated drug administration].
The study of the different effects of 5 FU administration before and after fractional irradiation on the medullar syndrome show the importance of the schedule in the effectiveness of the administration of the gamma rays and the cytostatic. As for the intestinal syndrome, the best results were obtained when 5 FU is administrated in one single dose per week 9 hours after the fifth irradiation for a two weeks schedule.
D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced / Q000209:etiology*; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000009:adverse effects*; D008526:Medulla Oblongata / Q000187:drug effects / Q000528:radiation effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D011832:Radiation Injuries / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D013577:Syndrome
D005472:Fluorouracil
Association de chimiothérapie et de radiothérapie. Effet différentiel sur le syndrome médullaire de l'association du fractionnement dans le temps de l'irradiation et de la drogue.