Coronary heart disease in treated hypertensive patients and risk-matched normotensive control subjects.
The incidence of coronary heart disease (CHD) was recorded prospectively for 543 persons--335 treated hypertensive patients and a group of 208 normotensive control subjects, individually matched to a subgroup of the hypertensive patients on the basis of seven risk factors. If antihypertensive therapy reduces CHD, CHD should have occurred at a rate predicted by initial blood pressure levels in the normotensive control subjects and at a rate predicted by post-treatment blood pressure levels in the hypertensive patients. A treatment effect seemed possible in hypertensive men, since CHD occurred at the rate predicted by post-treatment blood pressure levels. However, because the reduction was not statistically significant and was similar to a reduction observed in the normotensive control subjects, a treatment effect could not be confirmed. There was no evidence of a treatment effect in hypertensive women, since CHD occurred at a rate higher than that predicted by post-treatment blood pressure levels and the normotensive control subjects showed a lower than expected rate.
D001794:Blood Pressure; D003327:Coronary Disease / Q000453:epidemiology / Q000503:physiopathology / Q000517:prevention & control*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012306:Risk