Analysis of the cytotoxic T cell response to H-Y in CBA/H mice.
The dose response, kinetics, and target cell specificity of the H-Y immune Tc-cell response of fp-primed CBA/H mice was analyzed. Non-MHC genes were shown to influence responsiveness in fp-primed H-2k strains of mice. The possibility that dominant T-suppressor cells mask responsiveness in i.p. primed CBA/H mice was not confirmed in mixing experiments. Female spleen-adherent cells injected with male spleen cells i.p. elicited H-Y immune Tc-cell responses.
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D002874:Chromosome Mapping; D003602:Cytotoxicity, Immunologic; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology*; D006649:Histocompatibility Antigens; D007111:Immunity, Cellular; D007700:Kinetics; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012397:Rosette Formation; D012732:Sex Determination Analysis; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000961:Antilymphocyte Serum; D006183:H-2 Antigens; D006649:Histocompatibility Antigens