Mutagen-sensitive mutants in Neurospora.
Initial work on the fungus Neurospora crassa has shown that a least two DNA-repair systems exist in this eukaryote: excision repair and a mutation-prone repair. The evidence suggests that there is also a third repair system. Recently, new mutagen-sensitive strains have been isolated in several laboratories, but they are not yet fully characterized. A hunt for cytoplasmically inherited UV sensitivity has failed to turn up any such mutants among 25 new UV-sensitive isolates.
D004260:DNA Repair; D004271:DNA, Fungal / Q000528:radiation effects; D003851:Deoxyribonucleases / Q000172:deficiency; D004352:Drug Resistance, Microbial; D005111:Extrachromosomal Inheritance; D005260:Female; D005656:Fungal Proteins / Q000235:genetics; D007246:Infertility / Q000235:genetics; D008297:Male; D008741:Methyl Methanesulfonate / Q000494:pharmacology; D009153:Mutagens / Q000494:pharmacology*; D009491:Neurospora / Q000235:genetics*; D009492:Neurospora crassa / Q000187:drug effects / Q000201:enzymology / Q000235:genetics* / Q000528:radiation effects; D014466:Ultraviolet Rays
D004271:DNA, Fungal; D005656:Fungal Proteins; D009153:Mutagens; D008741:Methyl Methanesulfonate; D003851:Deoxyribonucleases