Effects of prolonged treatment with cyproterone acetate on hydrolytic enzymes in seminal vesicles of the mouse.
Daily s.c. injections of cyproterone acetate cause a time-related decrease in the weight and beta-glucuronidase activity of seminal vesicles in mouse. Protein content shows an initial increase and subsequently, after 120-180 days of treatment, a decline (reaching control levels). Acid phosphatase activity also decreases but only after long-term treatments. 5 alpha-DHT tends to bring the values of various parameters towards the control range. However, its effects are of a lesser magnitude in animals treated for 90 days with the antiandrogen. It is proposed that the antifertility action of cyproterone acetate is due mainly to its negative influence not only on the epididymis but also on seminal vesicles.
D000135:Acid Phosphatase / Q000378:metabolism*; D000818:Animals; D003534:Cyproterone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D017373:Cyproterone Acetate; D013196:Dihydrotestosterone / Q000494:pharmacology; D005966:Glucuronidase / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D012669:Seminal Vesicles / Q000033:anatomy & histology / Q000187:drug effects* / Q000201:enzymology
D013196:Dihydrotestosterone; D017373:Cyproterone Acetate; D003534:Cyproterone; D000135:Acid Phosphatase; D005966:Glucuronidase