Influence of in vivo hydrocortisone on some human blood leucocyte sub-populations. II. Effects on T cell-monocyte cooperation.
The effect of in vivo hydrocortisone (OHC) on various in vitro T cell responses was studied in five volunteers. Four hours after the administration of 300 mg OHC intravenously, the T cell response to soluble antigen (PPD) was only slightly depressed - as was the response to alloantigen - whereas the T cell response to autologous non-T cells was nearly abolished. In vivo OHC caused a profound depression of the number of circulating monocytes, but those still remaining in circulation had retained their antigen presenting capacity. In vitro OHC-treatment for four hours prior to PPD stimulation did not affect the antigen presenting capacity of monocytes or the proliferative responsiveness of T Cells.
D000328:Adult; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology*; D007519:Isoantigens / Q000276:immunology; D007958:Leukocyte Count; D008211:Lymphocyte Cooperation / Q000187:drug effects*; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D009000:Monocytes / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014373:Tuberculin / Q000276:immunology
D007519:Isoantigens; D014373:Tuberculin; D006854:Hydrocortisone