Tricatecholamide analogs of enterobactin as gallium- and indium-binding radiopharmaceuticals.
Isopropyl N-substituted tricatecholamide analogs of enterobactin have been found to form gallium and indium complexes with very high stability constants and to exhibit in vivo characteristics significantly different from gallium- or indium-transferrin and EDTA. The 3,4-DiP-LICAMS and TiP-MECAMS complexes were found to clear primarily through the kidneys, whereas the less polar 3,4-DiP-LICAM complex was eliminated through the liver. The rationale for developing new metal-binding analogs with larger organic groups attached to the amide nitrogens is discussed.
D000818:Animals; D004758:Enterobactin / Q000031:analogs & derivatives*; D005710:Gallium Radioisotopes / Q000378:metabolism*; D007204:Indium / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D007553:Isotope Labeling; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008433:Mathematics; D051381:Rats; D012694:Serine / Q000031:analogs & derivatives*; D013997:Time Factors; D014018:Tissue Distribution; D001743:Urinary Bladder / Q000378:metabolism
D005710:Gallium Radioisotopes; D007204:Indium; D004758:Enterobactin; D012694:Serine