Pharmacokinetic and anti-inflammatory properties in the rat of superoxide dismutases (Cu SODs and Mn SOD) from various species.
The comparison of the anti-inflammatory properties (carrageenan paw edema in the rat) of exogenous Cu SODs from various species and human Mn SOD administered at doses corresponding to clinical schedules, shows that human and bovine Cu SOD are fully active, whereas rat Cu SOD and Mn SOD are inefficient. This difference does not correspond to the similarity of pharmacokinetic properties (blood levels, subcellar location in kidney cortex) of the Cu proteins or to the increased circulating life time of Mn SOD. The pharmacological activity of exogenous SOD is limited to heterologous Cu SODs in the rat. A similar problem may occur in man. The true mechanism of action of Cu SOD remains to be elucidated.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002417:Cattle; D003300:Copper / Q000378:metabolism; D006801:Humans; D007672:Kidney Cortex / Q000201:enzymology; D007700:Kinetics; D008297:Male; D008345:Manganese / Q000378:metabolism; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism* / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D008345:Manganese; D003300:Copper; D013482:Superoxide Dismutase