Inhibition of 7,12-dimethylbenz[a]anthracene- and urethan-induced lung tumor formation in A/J mice by long-term treatment with dehydroepiandrosterone.
Long-term treatment with the adrenal steroid dehydro-epiandrosterone reduces weight gain without suppressing appetite and inhibits the occurrence of 7,12-dimethylbenz[a]anthracene- and urethan-induced lung tumors in A/J mice.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001551:Benz(a)Anthracenes; D001835:Body Weight / Q000187:drug effects; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000503:physiopathology; D014520:Urethane
D001551:Benz(a)Anthracenes; D014520:Urethane; D003687:Dehydroepiandrosterone; D015127:9,10-Dimethyl-1,2-benzanthracene