Biphasic development of splenic suppressor cells in tumor-bearing mice.
The splenic lymphocytes of A/J mice bearing anaplastic carcinoma (15091 A) exhibited a biphasic response to Concanavalin A-stimulated DNA synthesis during the progressive growth of tumors. In this paper we attribute the changing lymphocyte responses to Con A to the biphasic development of splenic suppressor cells in tumor-bearing mice. Anaplastic carcinoma in syngeneic A/J mice offers an ideal tumor model to study the functional relationship of suppressor cells to other parameters of immune response such as T-cells cytotoxicity.
D000818:Animals; D002448:Cell Adhesion; D003208:Concanavalin A / Q000494:pharmacology; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D051379:Mice; D008805:Mice, Inbred A; D009374:Neoplasms, Experimental / Q000276:immunology*; D013154:Spleen / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013997:Time Factors
D003208:Concanavalin A