Differential inhibition of contact sensitivity by suppressor T cells and suppressor factor induced by combined treatment with dinitrobenzenesulphonate and dinitrofluorobenzene.
Suppressor T cells acting on the efferent phase (Ts-eff) of dinitrofluorobenzene-contact sensitivity (DNFB-CS) were induced in BALB/c mice by injection of dinitrobenzenesulphonate (DNBSO3) and subsequent painting (sensitization) with DNFB. Ts-eff cells released a suppressor factor, antigen and strain specific, which was active in vivo in sensitized recipients. Administration of DNBSO3 alone generated suppressor T cells, which acted only on the afferent phase (Ts-aff). Suppressor T cells could not be detected in mice painted with DNFB and desensitized later by injection of DNBSO3.
D000818:Animals; D001557:Benzenesulfonates / Q000276:immunology*; D003877:Dermatitis, Contact / Q000276:immunology*; D004139:Dinitrofluorobenzene / Q000276:immunology*; D005260:Female; D006241:Haptens / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D009578:Nitrobenzenes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D001557:Benzenesulfonates; D006241:Haptens; D009578:Nitrobenzenes; C007488:dinitrobenzenesulfonic acid; D004139:Dinitrofluorobenzene