Dermatological findings in capacitor manufacturing workers exposed to dielectric fluids containing polychlorinated biphenyls (PCBs).
Significant occupational exposure to polychlorinated biphenyls (PCBs) may occur in the manufacturing of capacitors and transformers, in which PCBs are used as electrical insulators. Reports of adverse health effects resulting from PCB exposure have come primarily from an incident resulting from the accidental ingestion of contaminated rice oil in Japan in 1968 ("yusho"). Dermatological findings were prominent features and included pigmentation disturbances and chloracne. To evaluate the dermatological effects of long-term occupational exposure to PCBs, a cross-sectional clinical survey was conducted of 326 capacitor manufacturing workers. A high prevalence (37%) of dermatological abnormalities was found, but typical PCB-associated signs, such as chloracne, were less frequent than among patients with "yusho," despite high concentrations of plasma PCB. As association between dermatological signs and plasma levels of higher homologues of PCBs was suggested, but contaminants which have been reported to be present in commercial PCB mixtures (polychlorinated dibenzofurans) should be considered an etiologic factor or co-factor in the development of "PCB-associated" dermatological findings.
D000328:Adult; D003430:Cross-Sectional Studies; D009783:Dermatitis, Occupational / Q000139:chemically induced / Q000453:epidemiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011078:Polychlorinated Biphenyls / Q000097:blood / Q000506:poisoning*; D012871:Skin Diseases / Q000139:chemically induced*
D011078:Polychlorinated Biphenyls