Effect of hemodialysis on contact group of coagulation factors, platelets, and leukocytes.
Earlier reports have suggested possible activation and consumption of factor XII during hemodialysis. To investigate this possibility, a series of in vivo and in vitro experiments were conducted using different dialysis membranes and two different dialysates (acetate and bicarbonate). Factors XII and XI activities, factor XII concentration, and high-molecular-weight kininogen were measured. In addition, platelet count, white blood cell count, and hematocrit were monitored. Contrary to the previous reports, no discernible consumption of factor XII, factor XI, or high-molecular-weight kininogen was found irrespective of the type of membrane or the composition of the dialysate used. Transient leukopenia was noted with cellulosic membranes, whereas none occurred with polyacrylonitrile dialyzers. The composition of dialysate did not affect the white blood cell count during dialysis.
D000180:Acrylic Resins; D000328:Adult; D000368:Aged; D001797:Blood Protein Electrophoresis; D002482:Cellulose; D005172:Factor XI / Q000378:metabolism; D005174:Factor XII / Q000378:metabolism*; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis / Q000379:methods; D007704:Kininogens / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D006435:Renal Dialysis / Q000009:adverse effects*
D000180:Acrylic Resins; D007704:Kininogens; C010504:polyacrylonitrile; D005174:Factor XII; D002482:Cellulose; D005172:Factor XI