Regulation of IgE response by IgE binding factors.
T lymphocytes from rats infected with Nippostrongylus brasiliensis (Nb) release a soluble factor with affinity for IgE that selectively potentiates the IgE response to an unrelated antigen. The factor is derived from Fc omega receptors on T cells, binds to surface IgE on precursors of IgE-forming cells, and enhances their differentiation. The factor had a molecular weight between 10,000 to 20,000 and an affinity for lentil lectin. T cells from Nb-infected rats formed another IgE-binding factor upon incubation with rat IgE. The factor has the ability to suppress rather than enhance the IgE response. The IgE-specific suppressive factor is comparable to IgE-potentiating factor with respect to molecular weight and affinity for IgE but it fails to bind to lentil lectin. The IgE-specific suppressive factor is formed by lymphocytes complete Freund's adjuvant-treated rats. The results strongly suggest that IgE-binding factors are involved in the regulation of IgE response.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007165:Immunosuppression Therapy; D008198:Lymph Nodes / Q000276:immunology; D008970:Molecular Weight; D009559:Nippostrongylus / Q000276:immunology; D051381:Rats; D011961:Receptors, Fc / Q000276:immunology; D017455:Receptors, IgE; D011971:Receptors, Immunologic / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D011961:Receptors, Fc; D017455:Receptors, IgE; D011971:Receptors, Immunologic; D007073:Immunoglobulin E