Clofibrate-induced myotoxicity in rats. Temporal profile of myopathology.
In this report, the temporal sequence of myopathology during a clofibrate-induced muscular syndrome and its recovery in rats is described using histopathologic, histochemical and electron microscopic technics. Two stages of myopathology are described: an early stage characterized by myopathic features, and a later stage characterized by neurogenic features. Although muscle histology returns to normal after 1 week of discontinuing the drug, electron microscopic abnormalities persist through the second week. It is proposed that clofibrate, in addition to its myotoxic effect, may be neurotoxic.
D000818:Animals; D002994:Clofibrate / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D008854:Microscopy, Electron; D009132:Muscles / Q000473:pathology; D009133:Muscular Atrophy / Q000139:chemically induced* / Q000473:pathology; D051381:Rats
D002994:Clofibrate