Effects of neonatal treatment with clomipramine on adult ethanol related behavior in the rat.
Male rat pups were deprived of active (REM) sleep by giving daily injections of clomipramine between 8 and 21 days after birth. At the age of 55 days their ambulation and defecation in the open-field were tested. Thereafter, beginning at the age of 66 days, the voluntary ethanol consumption of the rats was tested for 4 weeks. Compared to saline-treated rats, the CLM rats consumed more ethanol, tended to be more active in the open-field, and responded with a decrease in ambulation to an ethanol dose which stimulated locomotion in control rats. These results indicate that neonatal treatment with clomipramine has an influence on later ethanol-related behavior in rats.
D000428:Alcohol Drinking; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D002997:Clomipramine / Q000494:pharmacology*; D004609:Eliminative Behavior, Animal / Q000187:drug effects; D006824:Hybridization, Genetic; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012895:Sleep, REM / Q000187:drug effects / Q000502:physiology*
D002997:Clomipramine