Nodulocystic acne, chromosomal abnormality, and diabetes mellitus.
Nodulocystic acne (NCA), a severe dermatologic facial condition, has previously been described in association with the XYY genotype. Presented herein is a severely retarded insulin-dependent diabetic with grade three hypospadias, fibrous testes, and severe NCA. Chromosomal analysis revealed his karyotype to be 46 XY+, (4 p+, 14q-). This case report demonstrates that NCA may occur with chromosomal abnormalities other than a 46 XYY genotype. The need to have karyotypic proof of a phenotypic diagnosis is emphasized.
D000152:Acne Vulgaris / Q000150:complications* / Q000473:pathology; D000328:Adult; D002869:Chromosome Aberrations / Q000473:pathology*; D025063:Chromosome Disorders; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000473:pathology; D006801:Humans; D008607:Intellectual Disability / Q000150:complications / Q000235:genetics / Q000473:pathology; D007621:Karyotyping; D008297:Male; D012867:Skin / Q000473:pathology*