Vitamin A does not alter immunosuppressive properties of simultaneously administered steroids.
The use of immunosuppressive steroids in transplant patients is associated with complications of wound healing and increased peptic ulceration. Vitamin A is known to reverse ill effects of steroids on wound healing and peptic ulcerogenesis; however, its effects on the immunologic properties of steroids are less well defined. The effect of vitamin A on steroid-induced immunosuppression was assessed through first and second set skin graft rejection, mixed lymphocyte culture reaction, and humoral antibody response to sheep erythrocytes. Results show tha vitamin A does not affect in vivo immunosuppression, although in vitro studies yield a conflicting result.
D000305:Adrenal Cortex Hormones / Q000037:antagonists & inhibitors*; D000818:Animals; D004912:Erythrocytes / Q000276:immunology; D006084:Graft Rejection / Q000187:drug effects; D006388:Hemagglutinins / Q000032:analysis; D007166:Immunosuppressive Agents / Q000037:antagonists & inhibitors*; D007959:Lymphocyte Culture Test, Mixed; D051381:Rats; D012756:Sheep / Q000276:immunology; D016038:Skin Transplantation; D014801:Vitamin A / Q000494:pharmacology
D000305:Adrenal Cortex Hormones; D006388:Hemagglutinins; D007166:Immunosuppressive Agents; D014801:Vitamin A