Normal and malignant T cells in the regulation of inflammation and immunity.
Normal T cells play an important role in the regulation of humoral immune responses by acting as potentiators (helper cells) or inhibitors (suppressor cells) of the process by which B cells mature into immunoglobulin-secreting plasma cells. Certain diseases in which malignant T cells appear to retain an immunoregulatory function are characterized by the propensity of a lymphomatous T-cell population to infiltrate skin. This may lead to an extensive inflammatory syndrome with cutaneous exfoliation. Some cutaneous T-cell lymphomas, as well as some T-cell neoplasms without dermatologic involvement, provide a homogeneous supply of T lymphocytes which have immunoregulatory functions. The availability of such neoplastic T immunoregulators might accelerate the serologic and biochemical analysis of the cellular control of normal immunity in man.
D000328:Adult; D000361:Agammaglobulinemia / Q000150:complications; D000818:Animals; D000912:Antibodies, Neoplasm / Q000276:immunology*; D000921:Antibody-Producing Cells / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D002999:Clone Cells / Q000276:immunology; D006801:Humans; D007223:Infant; D007249:Inflammation / Q000276:immunology*; D007938:Leukemia / Q000276:immunology; D007945:Leukemia, Lymphoid / Q000150:complications; D008223:Lymphoma / Q000276:immunology*; D051379:Mice; D012751:Sezary Syndrome / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000912:Antibodies, Neoplasm