[Iodine resorption from PVP-iodine preparations after their use in humans].
The absorption of iodine from iodine-containing PVP preparations and the possibility of iodide being split off from the organic compound were tested in subjects with normal thyroid function after they had used PVP-iodine as mouth-antiseptic (15 subjects), vaginal gel (20 subjects) or liquid soap (20 subjects). Serum I-, T3, T4, TSH and urinary iodide excretion were measured, as an index of thyroid function, before and after the PVP application. Increase in iodine supply was up to 2 mg daily in the test subjects. The overwhelming proportion of the absorbed iodine (greater than 75%) was as organically bound iodine. In none of the subjects was there evidence of developing hyper- or hypothyroidism as a result of the additional iodine supply. Approximate values for the biological half-life and the distribution volume of total iodine in the body were also obtained.
D000042:Absorption; D003802:Dentifrices / Q000009:adverse effects; D005260:Female; D006207:Half-Life; D006801:Humans; D007454:Iodides / Q000652:urine; D007455:Iodine / Q000378:metabolism*; D008297:Male; D011206:Povidone-Iodine / Q000378:metabolism; D012915:Soaps / Q000009:adverse effects; D013972:Thyrotropin / Q000032:analysis; D013974:Thyroxine / Q000032:analysis; D014284:Triiodothyronine / Q000032:analysis; D014622:Vaginal Creams, Foams, and Jellies / Q000009:adverse effects
D003802:Dentifrices; D007454:Iodides; D012915:Soaps; D014622:Vaginal Creams, Foams, and Jellies; D014284:Triiodothyronine; D011206:Povidone-Iodine; D013972:Thyrotropin; D007455:Iodine; D013974:Thyroxine
Resorption von Jod aus PVP-Jod-Präparaten nach Anwendung am Menschen.