[Hypolipidemic action of liposome-incorporated beta-sitosterol on rats].
Daily administration to rats with experimental hypercholesterolemia of beta-sitosterol (5 mg/kg) contained by lecithin liposomes provoked a 25% reduction in blood plasma cholesterol in 3 weeks, whereas crystalline beta-sitosterol (50 mg/kg) produced an analogous effect in 6 weeks. The drug under study decreased the level of atherogenic beta-lipoproteins in blood plasma and intestinal mucosa, raised the content of phospholipids in blood plasma and normalized the cholesterol/phospholipid ratio. The drug high hypolipidemic activity was supported in experiments in vitro with inverted sacs of the small intestine. The drug was found to be long-acting.
D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D003460:Crystallization; D004353:Drug Evaluation, Preclinical; D006937:Hypercholesterolemia / Q000188:drug therapy / Q000378:metabolism; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D008077:Lipoproteins, LDL / Q000378:metabolism; D008081:Liposomes / Q000008:administration & dosage*; D051381:Rats; D012855:Sitosterols / Q000627:therapeutic use*
D000960:Hypolipidemic Agents; D008077:Lipoproteins, LDL; D008081:Liposomes; D012855:Sitosterols; C025473:gamma-sitosterol; D002784:Cholesterol
Gipolipidemicheskoe deĭstvie zakliuchennogo v liposomy beta-sitosterina u krys.