The effect of the saturation and isomerization of dietary fatty acids on the osmotic fragility and water diffusional permeability of rat erythrocytes.
Weanling rats were fed semi-purified diets containing 15% by weight of either corn oil, a high oleic acid safflower oil, lard or hydrogenated soybean oil. Significant changes in the fatty acid composition of erythrocytes were induced by these dietary fats. The compositional changes did not effect water diffusional permeability, but did affect their osmotic fragility. An increased fragility appeared to be associated with an increased octadecenoate content of the membranes.
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004041:Dietary Fats / Q000494:pharmacology*; D004058:Diffusion; D004910:Erythrocyte Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000166:cytology*; D005227:Fatty Acids / Q000494:pharmacology*; D007536:Isomerism; D008297:Male; D008563:Membrane Lipids / Q000097:blood; D009996:Osmotic Fragility / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D014867:Water
D004041:Dietary Fats; D005227:Fatty Acids; D008563:Membrane Lipids; D014867:Water