Suppressor lymphocytes during open heart surgery.
Open heart surgery is associated with a moderate to severe postoperative of cell-mediated immunity. To characterize this defect, T-suppressor lymphocytes were studied in nine patients undergoing elective aortic/mitral valve replacement surgery. A decrease of the number of T-suppressor lymphocytes was observed after the operation. At the same time the activity of concanavalin A (Con A)- and phytohaemagglutinin (PHA)-induced suppressor cells decrease. Thus the decrease of cell-mediated immunity after open heart surgery seems not to be due to activation of suppressor lymphocytes.
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D006348:Cardiac Surgical Procedures; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012397:Rosette Formation; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D013806:Theophylline / Q000494:pharmacology
D011947:Receptors, Antigen, B-Cell; D013806:Theophylline