[Cholestatic effect of amphotericin B on the isolated perfused rat liver. Preliminary observations].
We evaluated the effect of Amphotericin B, a polyen antimycotic agent, on the excretory functions of the isolated perfused rat liver. At 5 X 10(-6) and 10(-5) M, Amphotericin caused a rapid dose-dependent cholestasis. This effect was paralleled by an increase in canalicular permeability, as evaluated by sucrose C14 B/P ratio. The data indicate that Amphotericin B is a potent cholestatic agent in vitro and suggest that caution should be exercised in the use of this drug in hepatopatic patients.
D000666:Amphotericin B / Q000494:pharmacology*; D000818:Animals; D002779:Cholestasis / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects*; D008297:Male; D010477:Perfusion; D010539:Permeability; D051381:Rats; D011919:Rats, Inbred Strains
D000666:Amphotericin B
Effetto colestatico della anfotericina B nel fegato di ratto isolato e perfuso. Osservazioni preliminari.