[Plasma protein and cerebral soluble protein disc electrophoresis in Down's syndrome].
Blood plasma proteins and soluble proteins from brain lobus frontalis of patients with mongolism were studied using polyacrylamide gel disc electrophoresis. A decrease in content of albumins, proteins of Gc system, transferrine, fast posttransferrines and an increase in amount of immunoglobulin proteins as well as of alpha 2-macroglobulin were observed in the preparations of blood plasma proteins. These alterations were apparently determined by impairments in functions of protein-synthesizing systems. Content of four different protein fractions was altered as shown by brain proteinogramms.
D000293:Adolescent; D001798:Blood Proteins / Q000032:analysis*; D001923:Brain Chemistry; D002648:Child; D002675:Child, Preschool; D003720:Densitometry; D004314:Down Syndrome / Q000097:blood / Q000378:metabolism*; D004589:Electrophoresis, Disc; D005625:Frontal Lobe / Q000032:analysis; D006801:Humans; D009419:Nerve Tissue Proteins / Q000032:analysis*; D012016:Reference Values; D012995:Solubility
D001798:Blood Proteins; D009419:Nerve Tissue Proteins
Disk-élektroforez belkov plazmy krovi i rastvorimykh belkov mozga pri sindrome Dauna.