[Effect of protein inhibitors of pancreatic proteinases on the breakdown and absorption of immunoreactive chicken ovalbumin in the intestines of adult rats].
Adult male Wistar rats received protein mixtures containing chick ovalbumin (OVA) intragastrically, whereupon immunoreactive OVA was determined in the chymus of the gastrointestinal tract and in blood serum by the immunofluorescence technique and radioimmunoassay. Combined administration of OVA and the soybean inhibitor of trypsin suppressed the degradation of the antigenic structure of OVA in the intestine and augmentation of immunoreactive protein absorption. The suppression was less pronounced if OVA was combined with chick ovomucoid.
D000818:Animals; D002645:Chickens; D007408:Intestinal Absorption / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D010047:Ovalbumin / Q000276:immunology / Q000378:metabolism*; D010059:Ovomucin / Q000378:metabolism; D010179:Pancreas / Q000201:enzymology*; D011480:Protease Inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000187:drug effects / Q000201:enzymology; D014360:Trypsin Inhibitor, Kunitz Soybean / Q000494:pharmacology
D011480:Protease Inhibitors; D010059:Ovomucin; D010047:Ovalbumin; D014360:Trypsin Inhibitor, Kunitz Soybean
Vliianie belkovykh ingibitorov pankreaticheskikh proteinaz na rasshcheplenie i vsasyvanie immunoreaktivnogo kurinogo oval'bumina v kishechnike vzroslykh krys.