[From the search for a lymphocytic chalone to the rediscovery of serum thymic factor (FTS)].
Looking for a "lymphocytic chalone" in Bovine spleen extracts, we isolated an immunosuppressive peptide, whose biochemical and biological properties are identical to those of the serum thymic factor FTS. This factor appeared to be a regulator of the humoral immune response.
D000818:Animals; D000961:Antilymphocyte Serum / Q000302:isolation & purification*; D002417:Cattle; D006131:Growth Inhibitors; D006462:Hemolytic Plaque Technique; D007166:Immunosuppressive Agents / Q000302:isolation & purification*; D013154:Spleen / Q000032:analysis*; D013935:Thymic Factor, Circulating / Q000302:isolation & purification*; D013951:Thymus Hormones / Q000302:isolation & purification*
D000961:Antilymphocyte Serum; D006131:Growth Inhibitors; D007166:Immunosuppressive Agents; D013951:Thymus Hormones; D013935:Thymic Factor, Circulating
De la recherche d'une chalone lymphocytaire à la redécouverte du facteur thymique sérique (FTS).