Zimelidine: comparison of different dosage regimes in general practice.
Various studies have demonstrated that depressive symptoms are a frequent and important problem in general practice. Zimelidine has been shown to have effective antidepressant activity. A controlled double-blind trial was set up to compare the efficacy and side effects of zimelidine when given as a single daily dose (200 mg night or morning) and when given as a divided dose (100 mg b.d.). These three dosage schedules were studied. The trial was conducted among patients attending their general practitioners and suffering from a depressive disorder. Using one of the three dosage schedules, these patients were treated with zimelidine for a minimum period of 6 weeks. Symptom severity was measured by means of the Hamilton Rating Scale for Depression and the side effects assessed using an adverse event record and a symptom checklist. The findings are discussed.
D000328:Adult; D000368:Aged; D000928:Antidepressive Agents / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D001977:Brompheniramine / Q000008:administration & dosage* / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy*; D005194:Family Practice; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D011725:Pyridines / Q000008:administration & dosage*; D015031:Zimeldine
D000928:Antidepressive Agents; D011725:Pyridines; D015031:Zimeldine; D001977:Brompheniramine