Corneomalacia perforans in a patient with rheumatoid arthritis.
Bilateral corneomalacia perforans occurred in a young woman who had had rheumatoid arthritis for 7 years. The perforations appeared to be precipitated by systemic corticosteroid therapy. The only symptom was a sudden loss of vision. Conservative treatment - withdrawal of the steroid therapy and application of soft contact lenses for 3 weeks - resulted in complete healing of the perforations and a marked increase in visual acuity.
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003263:Contact Lenses, Hydrophilic; D003316:Corneal Diseases / Q000139:chemically induced* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D011241:Prednisone / Q000009:adverse effects*; D014786:Vision Disorders / Q000209:etiology
D011241:Prednisone