The effect of sodium hyaluronate and sodium chondroitin sulfate on the coagulation system in vitro.
Healon (sodium hyaluronate) and sodium chondroitin sulfate (CDS) are injected in the ocular cavities in a variety of operations, mainly intraocular lens (IOL) implantation. Both Healon and CDS are structurally similar to heparin. We found that like heparin CDS has an inhibiting action on blood coagulation in vitro. The inhibiting activity is of the antithrombin type. Healon does not possess anticoagulant activity. Since the anticoagulant effect of sodium chondroitin sulfate is observable at concentrations likely to occur in vivo the substance may impair ocular hemostasis.
D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D002807:Chondroitin / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D006820:Hyaluronic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D007910:Lenses, Intraocular; D013918:Thrombin Time
D006820:Hyaluronic Acid; D002807:Chondroitin