The effect of dietary linoleic acid and pectin on lipoprotein and apolipoprotein A1 concentrations in rhesus monkeys.
Medium term effects (3 months) on serum lipoprotein levels of a diet with a high P/S ratio (2.2) and a low P/S ratio (0.3) were investigated in 13 normolipoproteinemic rhesus monkeys. Both diets were studied with and without added gel-forming fibre, as pectin. Addition of pectin did not have major influences on serum lipid levels. Changing from a low to a high P/S diet resulted in a significant decrease of total cholesterol (23%) and LDL cholesterol (18%) levels, but also HDL cholesterol (23%) and apolipoprotein A1 (Apo A1; 13%) concentrations fell significantly. However, after 12 weeks on the high P/S diet, HDL cholesterol concentrations rose by 24%, not significantly different from the levels during the low P/S diet. We conclude that the medium-term effects of a high P/S diet are a decrease in LDL cholesterol with only a transient effect on HDL cholesterol.
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003561:Cytarabine / Q000097:blood; D004032:Diet; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D004317:Doxorubicin / Q000097:blood; D005260:Female; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000494:pharmacology*; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008253:Macaca mulatta; D010368:Pectins / Q000494:pharmacology*; D013997:Time Factors
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D004041:Dietary Fats; D008041:Linoleic Acids; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D003561:Cytarabine; D004317:Doxorubicin; D010368:Pectins; D002784:Cholesterol; D019787:Linoleic Acid