Postcortisone medullary changes in the irradiated and unirradiated male Wistar rat.
Cortisone administration in male Wistar rat induces a depletion of the granulocytic-normoblastic cell population in the bone marrow in parallel with a numerical increase by accumulation of lymphoid and undifferentiated cells. These changes are more intense under irradiation conditions. The reversibility of medullary modifications is shown by the integrity of the reticulinic skeleton of the bone marrow.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects*; D003348:Cortisone / Q000009:adverse effects*; D008198:Lymph Nodes / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects
D003348:Cortisone