[Mathematical model for energy metabolism in erythrocytes. Independence of scaled glycolytic characteristics of individual features of the donors].
A mathematical model for energy metabolism of erythrocytes includes the first three enzymes of the Embden-Meyerhof pathway as well as total ATPase. It was assumed that the ATPase is strongly inhibited by AMP. The model was used to calculate the dependence of the rate of ATP production and glucose consumption on ATP concentration, i. e. characteristics of glycolysis. The scaled characteristics were plotted in relative units, the normal physiological values of the rates of glucose consumption and ATP concentration being taken for 100%. It was shown that the scaled characteristics show a coincidence, the precision being 20%, when the values of the enzyme activities and other parameters of the model vary within 100%. This agrees with the data, where the scaled characteristics of glycolysis in different donors (in all donors) coincide with experimental precision, while the values of the rates and concentrations with respect to the absolute value varied within 100%.
D000251:Adenosine Triphosphatases / Q000097:blood; D000255:Adenosine Triphosphate / Q000097:blood; D001782:Blood Donors; D004734:Energy Metabolism; D004912:Erythrocytes / Q000378:metabolism*; D006019:Glycolysis; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological
D000255:Adenosine Triphosphate; D000251:Adenosine Triphosphatases
Matematicheskaia model' energeticheskogo metabolizma eritrotsitov. Nezavicimost' normirovannoi kharakteristiki glikoliza ot individual'nykh osobennosteĭ donorov.