Biological evaluation of radiolabeled D-methionine as a parent compound in potential nuclear imaging.
Based on the high radioactivity uptake of some 14C-labeled D-amino acids in tumors and pancreas of mice, this investigation was undertaken to ascertain possible usefulness of radioactive D-methionine as a nuclear imaging agent. Radioactivity derived from D-[3,4-14C]-methionine in Ehrlich solid tumor was approximately three times higher than that from the L-isomer, but was the same as for mouse pancreas. Excretion rate of the radioactivity of D-[14C]-methionine into urine was approximately two times faster than that of the L-isomer. As compared with two potential imaging agents, 1-aminocyclopentane-1-carboxylic acid and alpha-aminoisobutyric acid, D-methionine showed almost the same radioactivity biodistribution in tumor and pancreas. These results suggest potential for D-methionine as a mother compound for use in tumor and pancreas imaging.
D000818:Animals; D002250:Carbon Radioisotopes / Q000378:metabolism; D002286:Carcinoma, Ehrlich Tumor / Q000000981:diagnostic imaging / Q000378:metabolism; D007536:Isomerism; D008715:Methionine / Q000378:metabolism; D051379:Mice; D009369:Neoplasms / Q000000981:diagnostic imaging*; D010179:Pancreas / Q000000981:diagnostic imaging* / Q000378:metabolism; D011877:Radionuclide Imaging; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D008715:Methionine