Generation of suppressor cells in the response of human lymphocytes to a polysaccharide from Candida albicans.
MPPS stimulation of human lymphocytes is characterized by a 2-way cooperation phenomenon, i.e., T help of B cells and B help of T cells. In this system suppressor cells are generated after 6 days of culture. They were characterized as Ia- T cells. Their suppressor activity affected both T and B cell stimulation, and it may involve 2 different mechanisms: direct cell suppression, and interaction with soluble helper factors.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002176:Candida albicans / Q000276:immunology*; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D000949:Histocompatibility Antigens Class II; D006801:Humans; D007700:Kinetics; D008214:Lymphocytes / Q000276:immunology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D011134:Polysaccharides / Q000494:pharmacology*; D012756:Sheep; D012995:Solubility; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000949:Histocompatibility Antigens Class II; D010835:Phytohemagglutinins; D011134:Polysaccharides; D003208:Concanavalin A