Contact sensitization to benzoyl peroxide.
The incidence of contact allergy to a 5% benzoyl peroxide (BP) gel has been studied by patch testing in 222 patients. Positive allergic reactions to BP were found in 3.1% of cases in a general clinical population (94 patients), whereas 5.8% of 69 patients with eczematous dermatoses were found to be BP-sensitized. In a group of acne vulgaris patients having used a commercial 5% or 10% BP gel for a period of 12 days to 3 1/2 years (mean: 10.7 months), positive allergic reactions were found in three cases (5.1%).
D000152:Acne Vulgaris / Q000188:drug therapy; D000293:Adolescent; D000328:Adult; D000368:Aged; D000941:Antigens / Q000276:immunology; D001585:Benzoyl Peroxide / Q000009:adverse effects* / Q000276:immunology / Q000627:therapeutic use; D003877:Dermatitis, Contact / Q000209:etiology*; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010545:Peroxides / Q000009:adverse effects*
D000941:Antigens; D010545:Peroxides; D001585:Benzoyl Peroxide