Ly-18, a new alloantigen present on cytotoxic T cells and controlled by a gene(s) to the Igh-V locus.
Antiserum raised in allotype-congenic mice recognizes a T cell differentiation antigen designated Ly-18. This antiserum was raised by immunization of (CB.20 x CBA-Igh-1b)F1 mice with secondary BALB/c anti-CBA allospecific cytotoxic cells. This antigenic specificity is expressed on cytotoxic T cells but not on cells proliferating in an MLR, plaque-forming cells specific for SRBC, or resting lymphoid cells. The expression of Ly-18 is controlled by gene(s) linked to the VH gene complex of Igh-1 allotype strains. There is no evidence at present for MHC gene control. Unlike other putative antibodies against antigen receptors, anti-Ly 18 does not block cytotoxicity. In addition, Ly-18 expression is not altered by the antigenic specificity of the Igh-1 effector. We conclude Ly-18 is a differentiation antigen present on a subpopulation of activated T cells. The gene(s) that codes for expression of Ly-18 is linked to the expression of Igh-1 genes.
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics; D002874:Chromosome Mapping; D003602:Cytotoxicity, Immunologic; D008040:Genetic Linkage; D007106:Immune Sera / Q000494:pharmacology; D007135:Immunoglobulin Variable Region / Q000235:genetics; D007519:Isoantigens / Q000235:genetics*; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011817:Rabbits; D011971:Receptors, Immunologic; D013601:T-Lymphocytes / Q000276:immunology*
D000954:Antigens, Surface; D007106:Immune Sera; D007135:Immunoglobulin Variable Region; D007519:Isoantigens; D011971:Receptors, Immunologic