Mitogenic response of lymphocytes from C3H/HeJ mice in the presence of lipid A and lipid A fractions.
Purified lipid A and eight fractions of lipid A were examined for the ability to elicit a mitogenic response in spleen lymphocytes of endotoxin-resistant C3H/HeJ mice. The pattern of results obtained with different lipid A fractions was similar to that observed with spleen cells from the endotoxin-responsive C57Bl/6J mouse. Although the absolute mitogenic response of C3H/HeJ lymphocytes to lipid A was diminished, the cells apparently were completely normal with respect to the pattern of relative mitogenic responses induced by purified fractions of lipid A.
D000818:Animals; D066298:In Vitro Techniques; D008050:Lipid A / Q000032:analysis / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D013045:Species Specificity
D008050:Lipid A