The permeability of human lymphocytes to chloride.
The normal amount of Cl in human lymphocytes is 82 mmoles/kg wet weight. Half of this undergoes rapid self-exchange with a half-time of 3 minutes, while the remainder exchanges slowly with a half-time of 180 minutes. The fast fraction of self-exchange of Cl also undergoes a rapid net loss into medium with a low concentration of Cl. Thus, exchange of Cl in lymphocytes has properties like that of K and Na with permeability constants on the order of 10(-6) cm/sec. The results are compatible with a simple model in which the fast fractions are dissolved within ordered cellular water at concentrations less than in the external medium and the slow fractions are adsorbed onto intracellular macromolecules.
D000328:Adult; D002463:Cell Membrane Permeability; D002712:Chlorides / Q000097:blood*; D002713:Chlorine; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008214:Lymphocytes / Q000378:metabolism*; D011868:Radioisotopes
D002712:Chlorides; D011868:Radioisotopes; D002713:Chlorine