[Chemical protection against the long-term effects in mice exposed to supralethal doses of X rays].
Our results demonstrate that mixtures of radioprotectors increase the degree of protection against the short and the long term effects compared with that obtained with each substance given separately. The most potent mixtures of radioprotectors (AET, MEA, Cyst, GSH, 5-HT) yield for the long term survival a dose reduction factor of 2.1. Pulmonary lesions are most often the cause of death in protected mice irradiated with 13.5 Gy or more. At the time of death signs of sclerosis and atrophy in several tissues are associated with these lung lesions in most mice and increase with dose and time after exposure. The tissues most affected are the kidney, the alimentary tract, the liver and the lymphoid tissues.
D000818:Animals; D004064:Digestive System / Q000528:radiation effects; D005260:Female; D007668:Kidney / Q000528:radiation effects; D008099:Liver / Q000528:radiation effects; D008168:Lung / Q000528:radiation effects; D008214:Lymphocytes / Q000528:radiation effects; D051379:Mice; D008807:Mice, Inbred BALB C; D011832:Radiation Injuries / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013997:Time Factors
D011837:Radiation-Protective Agents
Protection chimique contre les effets à long terme survenant chez les souris irradiées par des doses supralétales de rayons X.