Release and vasoconstrictor effect of leukotriene C-like immunoreactive material in the anaphylactic guinea-pig mesenteric vascular bed.
Antigen challenge of sensitized isolated guinea-pig mesentery perfused under constant pressure resulted in a significant flow reduction, which was paralleled by the release of leukotriene (LT)C4-like immunoreactivity into the perfusates. The lipoxygenase inhibitor quercetin inhibited the release of immunoreactive LTC4 and simultaneously abolished the antigen-induced mesenteric flow reduction. Mesenteric flow reduction was also observed after injection of exogenous LTC4. The results demonstrate that LTC4 is a constrictor of the mesenteric vascular bed and that endogenous LTC4-like immunoreactive material is a mediator of anaphylactic vasoconstriction in the guinea-pig mesentery.
D000707:Anaphylaxis / Q000503:physiopathology*; D000818:Animals; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D008643:Mesentery / Q000098:blood supply / Q000378:metabolism*; D011794:Quercetin / Q000494:pharmacology; D011863:Radioimmunoassay; D013189:SRS-A / Q000378:metabolism* / Q000502:physiology; D013152:Splanchnic Circulation / Q000187:drug effects; D013997:Time Factors; D014661:Vasoconstriction
D013189:SRS-A; D011794:Quercetin