Assessment of potential activation of gonyautoxin V in the stomach of mice and rats.
Transformation of gonyautoxin V, a paralytic shellfish toxin of low lethality, to highly potent saxitoxin in the stomach was assessed by incubation in gastric juices. Only 8-15% of the toxin was converted to saxitoxin under drastic conditions. Comparison of oral and i.p. LD50 values of both toxins indicated that little conversion took place in the stomach of mice.
D000818:Animals; D001711:Biotransformation; D005750:Gastric Juice / Q000378:metabolism*; D051379:Mice; D051381:Rats; D012530:Saxitoxin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000633:toxicity; D013045:Species Specificity
D012530:Saxitoxin; C042155:gonyautoxin V