Effect of Tween 80 on adriamycin cytotoxicity in murine P388 leukemia.
Studies on mice bearing P388 adriamycin sensitive and resistant lymphocytic leukemia were carried out to compare antitumor activity of adriamycin dissolved in Tween 80 (10% in distilled water) with that of adriamycin dissolved in distilled water alone. The antitumor activity of adriamycin dissolved in acqueous solutions of Tween 80 was higher than that of adriamycin dissolved in distilled water against P388 leukemia sensitive to adriamycin. However, no change in the activity was observed in P388 leukemia resistant to adriamycin when the drug was administered either in aqueous solution of Tween 80 or in distilled water alone.
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D004317:Doxorubicin / Q000008:administration & dosage*; D004351:Drug Resistance; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051379:Mice; D014677:Pharmaceutical Vehicles; D011136:Polysorbates / Q000494:pharmacology / Q000627:therapeutic use*
D014677:Pharmaceutical Vehicles; D011136:Polysorbates; D004317:Doxorubicin