Differing sensitivity to fluorescent light in Chinese hamster cells containing equally incorporated quantities of BUdR versus IUdR.
Chinese hamster V79 cells that had incorporated approximately equal levels of either BUdR or IUdR into their DNA were found to be equal sensitizers to X rays. However, BUdR-substituted cells were much more sensitive to fluorescent light than IUdR-substituted cells, both on a cell survival basis and by the initial number of single strand DNA breaks induced. Since a major toxicity to the use of BUdR clinically has been light-induced skin rash, these data indicate that the use of IUdR clinically might cause less untoward toxicity but yet provide the same radiosensitization as BUdR.
D000818:Animals; D001973:Bromodeoxyuridine / Q000378:metabolism*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D007065:Idoxuridine / Q000378:metabolism*; D008027:Light; D010787:Photosensitivity Disorders / Q000139:chemically induced; D011838:Radiation-Sensitizing Agents / Q000378:metabolism*
D011838:Radiation-Sensitizing Agents; D001973:Bromodeoxyuridine; D007065:Idoxuridine