[Frontal evoked potentials and sensitivity to methylphenidate. Individual differences].
Auditory evoked potentials (AEPs) were recorded from 2 sites (Cz and Fz) on 17 subjects while awake. Five sound intensities were used (40-50-60-70-80 dB). Regression slopes relating AEP amplitude (N1-P2 component) to stimulus intensity were used to describe augmentation or reduction (A/R) of amplitude with increasing intensity. The individual differences thereby obtained have been related with the individual responsiveness to methylphenidate (MPD) measured by the modifications of polygraphic sleep parameters after absorption of this substance. The sleep parameters were recorded under 3 conditions: N1, night of habituation; N2, reference night (placebo); N3, night after 20 mg of methylphenidate (MPD); nights 2 and 3 consisted of a double blind cross-over. For the placebo condition, the lower the A/R slope while awake (and particularly the Fz slope), the higher the sleep efficiency, with scarcity of nocturnal awakening and precocity of the morning awakening. Individual differences concerning MPD responsiveness measured with sleep parameter modifications are significantly correlated with the frontal A/R slopes: the wakefulness effect of MPD increases as the frontal A/R slope weakens while a paradoxal drowsiness effect is observed at the other extreme (frontal augmenters). Moreover, sleep modifications due to the first night effect show similarities with those due to MPD and are correlated in the same way with frontal A/R slopes.
D000328:Adult; D004361:Drug Tolerance; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects*; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects
D008774:Methylphenidate
Potentiels évoqués frontaux et sensibilité au méthylphénidate. Differences individuelles.