[Bactericidal activity of the serum against Staphylococcus aureus grown in the presence of subinhibitory doses of cefamandole and gentamicin].
Growth of S. aureus in the presence of subinhibitory concentrations of cefamandole alone (at 1/5 the MIC) or with gentamicin (both at 1/5 the MIC) produced large, globular cells with reduced viability (50%) as compared to untreated bacteria. Gentamicin (1/5 the MIC) did not modify bacteria and also reduced viability of inoculum (57% vs. controls). Cefamandole treated bacteria were more susceptible to the rat serum bactericidal activity then control bacteria. The growth of S. aureus in the presence of cefamandole plus gentamicin did not modify further bacterial susceptibility to serum opsonins. The data suggest that even at subinhibitory concentrations cefamandole may exert an antibacterial effect by acting in cooperation with serum factors.
D000818:Animals; D001770:Blood Bactericidal Activity; D002435:Cefamandole / Q000008:administration & dosage / Q000494:pharmacology*; D005839:Gentamicins / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013211:Staphylococcus aureus / Q000187:drug effects*
D005839:Gentamicins; D002435:Cefamandole
Attivita' battericida del siero nei confronti di Staphylococcus aureus cresciuto in presenza di dosi subinibenti di cefamandolo e gentamicina.