Use of taste repellants and emetics to prevent accidental poisoning of dogs.
Twelve taste repellents and 3 oral emetics were tested. The taste repellents were capsaicin, capsicum, oleoresin, sucrose octaacetate, quinine tonic, quassia wood extract, vanillamide, horseradish extract, caffeine, pepperoni enhancer, acorn extract, and commercially available bitter and hot flavors. The emetics tested were: antimony potassium tartrate, apomorphine, and copper sulfate. Intake of a 20% sucrose solution by Beagles was significantly depressed by addition of vanillamide at concentrations greater than 0.001%, by capsicum and capsaicin at concentrations greater than 0.01%, and by horseradish extract, pepperoni enhancer, and a commercially available hot flavor at concentrations greater than 0.1%. Antimony potassium tartrate, when added to the 20% sucrose solution at a concentration of 0.1%, produced emesis as did apomorphine at a concentration of 0.005% and copper sulfate at 1%. When the emetic antimony potassium tartrate was combined with vanillamide in a 20% sucrose solution, intake was reduced to less than 20 ml, and vomiting occurred within 15 minutes. Capsaicin (0.02%) inhibited intake of ethylene glycol to less than the lethal dose in 5 dogs tested. Incorporation of such taste repellents and/or emetics into potentially poisonous substances would reduce accidental poisoning of animals and children.
D000056:Accident Prevention; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002211:Capsaicin / Q000494:pharmacology; D003300:Copper / Q000494:pharmacology; D019327:Copper Sulfate; D004283:Dog Diseases / Q000517:prevention & control*; D004285:Dogs; D004639:Emetics / Q000494:pharmacology*; D005260:Female; D005421:Flavoring Agents / Q000494:pharmacology*; D008297:Male; D010575:Pesticides / Q000506:poisoning*; D013649:Taste / Q000187:drug effects*
D004639:Emetics; D005421:Flavoring Agents; D010575:Pesticides; D003300:Copper; D019327:Copper Sulfate; D001058:Apomorphine; D002211:Capsaicin