Hepatic pathology in vitamin A toxicity.
This paper documents a case of vitamin A toxicity presenting with splenomegaly and ascites. The light microscopic, electron microscopic, and fluorescent findings are described in detail. The principal histopathologic finding was marked perisinusoidal fibrosis. The role of Ito cells in the storage of lipid-soluble vitamins and their subsequent transformation to fibroblasts producing collagen are discussed.
D000328:Adult; D005260:Female; D006801:Humans; D008099:Liver / Q000032:analysis / Q000187:drug effects / Q000473:pathology* / Q000648:ultrastructure; D014801:Vitamin A / Q000009:adverse effects* / Q000032:analysis
D014801:Vitamin A