Effects of synthetic porcine GIP on the PP release in healthy subjects.
Six healthy subjects were given 30 min intravenous infusions of synthetic porcine GIP in doses of 0.52, 1.04 and 1.56 micrograms X kg-1 X h-1 on one occasion and a bolus injection of 1 microgram X kg-1 on another. The GIP infusions gave physiological GIP levels which did not affect plasma PP, whereas the GIP injection giving supraphysiological GIP levels evoked a significant elevation in plasma PP.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D005215:Fasting; D005260:Female; D005749:Gastric Inhibitory Polypeptide / Q000008:administration & dosage / Q000494:pharmacology*; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010191:Pancreatic Polypeptide / Q000097:blood / Q000378:metabolism*
D005768:Gastrointestinal Hormones; D005749:Gastric Inhibitory Polypeptide; D010191:Pancreatic Polypeptide