Antagonism by haloperidol of the suppression of exploratory locomotor activity induced by the local application of (-)3-(3-hydroxyphenyl)-N-n-propylpiperidine into the nucleus accumbens of the rat.
The injection of (-)3-PPP into the nucleus accumbens, 10 microgram/side, produced a suppression of exploratory locomotor activity without affecting treadmill locomotion. Furthermore, the suppression of exploratory locomotor activity produced by (-)3-PPP was antagonized by the administration of haloperidol, 25-50 micrograms/kg i.p.
D000818:Animals; D005106:Exploratory Behavior / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000502:physiology; D010880:Piperidines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000187:drug effects*
D010880:Piperidines; C026539:preclamol; D006220:Haloperidol