Interaction with host stroma as a promotional factor in tumor malignancy.
Cells of a Yoshida sarcoma implanted subcutaneously in the rat are heterogeneous. Nuclei vary microscopically from regularly vesicular to irregular and hyperchromatic. Cells with hyperchromatic nuclei are in remarkably close association with stromal elements. This finding is consistent with the theory that stromal influences have a promotional effect on tumor cells. The nature of the hypothetical factor is conjectural.
D000818:Animals; D005260:Female; D009361:Neoplasm Invasiveness / Q000473:pathology*; D051381:Rats; D012517:Sarcoma, Yoshida / Q000473:pathology