Potentiation of ampicillin skin reactions by allopurinol or hyperuricemia.
Of 4434 hospitalized medical patients who received ampicillin in the absence of allopurinol, 251 (5.9 per cent) developed a rash within 21 days of exposure. Of 252 patients who received ampicillin and allopurinol together, 35 (13.9 percent) developed a rash. The present data confirm the previously reported increase in rash frequency in patients who receive both ampicillin and allopurinol.
D000493:Allopurinol / Q000009:adverse effects*; D000667:Ampicillin / Q000009:adverse effects*; D003875:Drug Eruptions / Q000209:etiology*; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008297:Male; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid; D000493:Allopurinol; D000667:Ampicillin