Effect of SAS 650 (Furofenac) on malondialydehyde production by platelets.
The activity of SAS 650, a new anti-inflammatory drug, on ex vivo and in vitro MDA production by platelets was compared to that of aspirin. The drug induced dose-dependent inhibition of in vitro MDA production by rat and guinea-pig platelets and also had good activity after 30 second of incubation in rat platelets, quicker than aspirin. SAS 650 preincubation reduced the in vitro inhibitory effect of ASA, as shown also by ex vivo experiments. The results of the present study support the involvement of SAS 650 in the platelet cyclooxygenase pathway.
D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D001792:Blood Platelets / Q000378:metabolism*; D006168:Guinea Pigs; D007700:Kinetics; D008297:Male; D008314:Malonates / Q000096:biosynthesis*; D008315:Malondialdehyde / Q000096:biosynthesis*; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D000085:Acetates; D000893:Anti-Inflammatory Agents; D008314:Malonates; D008315:Malondialdehyde; C023654:furofenac; D001241:Aspirin