Effect of irradiation on Concanavalin A-induced suppression of mitogen responses in human lymphocyte cultures.
Concanavalin a (Con A)-induced and Con A-inducible human suppressor lymphocytes were examined for their radiosensitivity (16 Gy). It was observed that X-ray exposure of Con A-induced suppressor cells abolished some of the suppressive activity. Exposure of lymphocyte preparations did not prevent the subsequent induction by Con A of suppressor cells capable of inhibiting mitogen responses of lymphocytes. The relative size of the Con A-inducible suppressor population in the blood was not changed in breast cancer patients after local radiation therapy.
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000532:radiotherapy*; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000528:radiation effects*; D008875:Middle Aged; D008937:Mitomycins / Q000494:pharmacology; D050378:T-Lymphocytes, Regulatory / Q000528:radiation effects*
D008937:Mitomycins; D003208:Concanavalin A