Inhibition of brain enolases by acrylamide and its related compounds in vitro, and the structure-activity relationship.
Acrylamide and its related compounds inhibited brain enolases in vitro independently of their neurotoxicity. The inhibitory potency was a function of the binding constants of the compounds for phenylalanine. The binding constant for tryptophan was higher in neurotoxic compounds than in non-neurotoxic ones.
D000178:Acrylamides / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D008297:Male; D010649:Phenylalanine / Q000378:metabolism; D010751:Phosphopyruvate Hydratase / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
D000178:Acrylamides; D007527:Isoenzymes; D010649:Phenylalanine; D010751:Phosphopyruvate Hydratase