Dept. of Microbiology, School of Medicine, East Carolina University, Greenville, NC.
The responsiveness of spleen cells from C57BL/6J mice to various immunogenic stimuli was examined during the progressive growth of a poorly immunogenic fibrosarcoma T241. A strong correlation was observed between the progressive tumor growth and the depression of response to Concanavalin A, lipopolysaccharide, sheep red blood cells, and alloantigens in mixed lymphocyte reaction and cell-mediated lympholysis (CML). The maximum depression of these immune responses occurred when the animals had grown tumors for 3-4 weeks. Furthermore, serum from these animals collected 20 days after tumor transplantation was highly immunosuppressive. The possible mechanisms of tumor-induced immunosuppression have been discussed.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D004912:Erythrocytes / Q000276:immunology; D005354:Fibrosarcoma / Q000276:immunology*; D007108:Immune Tolerance; D007519:Isoantigens / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008934:Mitogens / Q000494:pharmacology; D012513:Sarcoma, Experimental / Q000276:immunology; D012756:Sheep / Q000276:immunology
D007519:Isoantigens; D008934:Mitogens