The metabolic fate of [14C]oxaprotiline.HCl in man. II. Isolation and identification of metabolites.
The new antidepressant agent oxaprotiline is extensively metabolized by man. Following an oral 50 mg dose of racemic [14C]oxaprotiline, most of the 14C was excreted in the urine as metabolites (greater than 98% total 14C); only 1% was excreted unchanged. Glucuronidation at the carbinol group of the molecule is the major metabolic pathway (83%). The two diastereoisomeric glucuronides were separated; the more polar O-glucuronide of S(+)-oxaprotiline predominates (44%), suggesting stereoselective disposition of the two enantiomers. Oxidative pathways are minor, and yield desmethyl oxaprotiline (10%) and 3-hydroxy R(-)-oxaprotiline (4%), both of which are conjugated with glucuronic acid. The biotransformation of oxaprotiline in man is less complex than that of other polycyclic antidepressants, which are metabolized mainly by oxidative reactions.
D000873:Anthracenes / Q000652:urine*; D000928:Antidepressive Agents / Q000652:urine*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007700:Kinetics; D008297:Male; D008376:Maprotiline / Q000031:analogs & derivatives / Q000652:urine*; D008875:Middle Aged; D013237:Stereoisomerism
D000873:Anthracenes; D000928:Antidepressive Agents; D008376:Maprotiline; C027299:hydroxymaprotilin