[Experimental studies on the effect of thyrocalcitonin on secondary bone healing (author's transl)].
The effect of thyrocalcitonin on secondary bone healing was studied in 180 Sprague-Dawley-rats. The right tibia of all the rats was osteotomized. Half of the animals was treated with thyrocalcitonin. Until the 60th postoperative day, the increase in 99mTc-methylendiphosphonate activity was measured and significant differences in ratios were noted. Between the postoperative days 10 to 25, there was a significant difference in the impulse quotients between the thyrocalcitonin and untreated rats (P less than 0.05). These results indicate that thyrocalcitonin may aid in secondary bone healing.
D000818:Animals; D002116:Calcitonin / Q000627:therapeutic use*; D004164:Diphosphonates; D005593:Fracture Fixation, Internal; D008297:Male; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium; D013669:Technetium Tc 99m Medronate; D013978:Tibial Fractures / Q000000981:diagnostic imaging / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects*
D004164:Diphosphonates; D013667:Technetium; D002116:Calcitonin; D013669:Technetium Tc 99m Medronate
Experimentelle Untersuchungen zum Einfluss von Calcitonin auf die sekundäre Knochenbruchheilung.