Absence of arsenite mutagenicity in E coli and Chinese hamster cells.
Because exposure to compounds of arsenic has been implicated as a cause of cancer, an investigation of the mutagenicity of sodium aresenite in E coli and in Chinese hamster cells was performed. In the E coli system, Trp + revertants were not induced by arsenite in a variety of experimental protocols including spot tests, treat and plate protocols, and fluctuation tests. The mutator effect of a tif-1 strain was partially blocked by arsenite. Arsenite did not cause the induction of lambda prophage. In Chinese hamster cells, arsenite did not induce ouabain-resistant mutants or thioguanine-resistant mutants. We conclude that arsenite is not mutagenic to E coli or to Chinese hamster cells. When added to the plating medium, arsenite can act as an anti-mutagen by inhibition of induction of the error-prone SOS repair system in E coli.
D000818:Animals; D001151:Arsenic / Q000494:pharmacology*; D018053:Arsenites; D010582:Bacteriophage lambda / Q000254:growth & development; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D004260:DNA Repair / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D009152:Mutagenicity Tests; D009154:Mutation; D017670:Sodium Compounds; D014775:Virus Activation / Q000187:drug effects
D018053:Arsenites; D017670:Sodium Compounds; C017947:sodium arsenite; D001151:Arsenic