[Experimental and clinical study of the biliary elimination of mezlocillin (author's transl)].
The biliary elimination of mezlocillin was studied in 5 perfused rabbit liver preparations. After adding 10 mg of mezlocillin to the perfusion medium, the biliary peak averaged 758 +/- 129 microgram/ml and total mezlocillin recovery within 3hr amounted to 20.3% of the administered dose. In 5 healthy subjects, the mean levels in the duodenal fluid collected during the 4 hrs following an infusion of 5 g of mezlocillin ranged from 440 to 637 microgram/ml. In cholecystectomized patients provided with a T-tube drainage, the maximal concentration after the same dosage (n = 10) was 505 +/- 158 microgram/ml and cumulative biliary excretion of mezlocillin over a 12 hr period corresponded to 1.3% of the administered dose. Under the same conditions, after intra-muscular injection of 1 g of mezlocillin to 10 subjects, the biliary peak averaged 292 +/- 58 microgram/ml and the total biliary recovery 2.6% of the administered dose. In 10 patients undergoing biliary tract surgery, the levels determined 1 hr after IV injection of 2 g of mezlocillin reached 896 +/- 196 microgram/ml and 402 +/- 133 microgram/ml in the main duct and in the gallbladder bile, respectively. These results were compared with the values obtained under identical conditions with 12 other beta-lactam antibiotics.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D004386:Duodenum; D006801:Humans; D007432:Intraoperative Period; D008099:Liver; D008802:Mezlocillin; D010406:Penicillins / Q000097:blood / Q000378:metabolism*; D010477:Perfusion; D011817:Rabbits; D013396:Suction; D013997:Time Factors
D010406:Penicillins; D008802:Mezlocillin
Détermination expérimentale et étude clinique de l'élimination bilaire de la mezlocilline.