Formulation of a stable vidarabine phosphate injection.
An injection fluid with vidarabine phosphate (37.5 mg/ml, pH 7.4) was formulated. After steam sterilization for 20 min at 120 degrees C a 6.1% degradation was observed. No significant (p greater than 0.05) degradation could be observed after heating in steam for 30 min at 100 degrees C and after storage for four months at 4 degrees C. From the results of an investigation of the degradation rate at elevated temperatures a negligible loss of content after a three years' storage period at 4 degrees C could be predicted.
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002855:Chromatography, Thin Layer / Q000379:methods; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007267:Injections; D010084:Oxidation-Reduction; D013696:Temperature; D014740:Vidarabine / Q000032:analysis
D014740:Vidarabine