Influence of propranolol, metoprolol, and pindolol on mucociliary clearance in patients with coronary heart disease.
The effects of the beta-adrenoceptor-blocking drugs propranolol, metoprolol, pindolol, and placebo, on mucociliary clearance were studied in three groups of 6 subjects with coronary heart disease and normal lung function. Clearance rates of inhaled 99mTc-labeled human serum albumin minimicrospheres were determined over the apical right region of the lung with a gamma camera. A 3-day medication of propranolol 40 mg b.i.d., when compared with placebo, led to a significant decrease (p less than or equal to 0.05) in mucociliary clearance. Metoprolol 50 mg b.i.d. or pindolol 5 mg b.i.d. did not show any influence on mucociliary clearance. Implications for the use of different types of beta-adrenoceptor-blocking drugs in the treatment of coronary heart disease are discussed.
D000328:Adult; D000368:Aged; D001980:Bronchi / Q000187:drug effects; D002923:Cilia / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008168:Lung / Q000187:drug effects*; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use*; D008875:Middle Aged; D009093:Mucus / Q000187:drug effects*; D010869:Pindolol / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use*; D014132:Trachea / Q000187:drug effects
D011433:Propranolol; D010869:Pindolol; D008790:Metoprolol