The detection of mutants in mice by electrophoresis: results of a model induction experiment with procarbazine.
Male mice of the DBA/2J strain were treated with the mutagen procarbazine and mated with C57BL/6J females. Offspring and parents were then analyzed for electrophoretically expressed mutations. A control group, not mutagen treated, was also examined. Two mutants probably due to induction were identified, and several of spontaneous origin were also found.
D000818:Animals; D004592:Electrophoresis, Starch Gel; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005914:Globins / Q000235:genetics; D007668:Kidney / Q000201:enzymology; D008291:Malate Dehydrogenase / Q000235:genetics; D008297:Male; D051379:Mice; D009154:Mutation / Q000187:drug effects*; D010733:Phosphoglucomutase / Q000235:genetics; D010734:Phosphogluconate Dehydrogenase / Q000235:genetics; D011344:Procarbazine / Q000494:pharmacology*
D011344:Procarbazine; D005914:Globins; D008291:Malate Dehydrogenase; D010734:Phosphogluconate Dehydrogenase; D010733:Phosphoglucomutase