[Acute non-bacterial interstitial tubular nephritis].
With the idea in mind to review the etiologic characteristics and evolution of nonbacterial acute tubulointerstitial nephritis, 29 cases seen at the Hospital Infantil de México between 1972 and 1978 were studied. The ages of patients fluctuated from 3 months to 14 years; 18 of them were males. The disease was associated with the administration of nephrotoxic agents, fundamentally antibiotics, being in order of frequency; gentamicin, kanamycin, ampicillin and streptomycin. The main initial manifestations were hematuria and oliguria. At the onset of the disease, acute renal failure was found in 5 of the patients. Two patients developed chronic renal failure, which in one of them was caused by diphenylhydantoin and was reversible on discontinuance of the drug. There were 3 deaths which in 2 cases followed infectious complication and in 1, renal failure. Considerations are made on the pathogenesis of the disease which is predominantly immunologic of following direct toxic action.
D000208:Acute Disease; D058186:Acute Kidney Injury / Q000209:etiology; D000293:Adolescent; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001706:Biopsy; D002648:Child; D002675:Child, Preschool; D005260:Female; D006417:Hematuria / Q000209:etiology; D006801:Humans; D007105:Immune Complex Diseases / Q000150:complications; D007223:Infant; D007684:Kidney Tubules / Q000473:pathology; D008297:Male; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D009846:Oliguria / Q000209:etiology
D000900:Anti-Bacterial Agents
Nefritis tubulointersticial aguda no bacteriana.