Regulation of contact sensitivity of oxazolone by lipopolysaccharide-induced B lymphocytes.
The activation of B lymphocytes, which regulates contact sensitivity to oxazolone, was studied in mice injected with bacterial lipopolysaccharide (LPS) 24 h before sensitization. These regulatory cells bear Ig receptors, are sensitive to mitomycin C treatment in vitro, and have precursors sensitive to cyclophosphamide. Their early induction needed the mitogenic signal of LPS, in that LPS deprived of lipid A did not induce B-cell-mediated suppression, and required little or no T-cell help, as they were produced in B mice. Possible mechanisms by which LPS-induced regulatory cells act and their relevance to other suppressor systems are discussed.
D000468:Alkalies / Q000494:pharmacology; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D003520:Cyclophosphamide / Q000494:pharmacology; D003877:Dermatitis, Contact / Q000276:immunology*; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010080:Oxazoles / Q000494:pharmacology*; D010081:Oxazolone / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000468:Alkalies; D008070:Lipopolysaccharides; D010080:Oxazoles; D010081:Oxazolone; D003520:Cyclophosphamide