Weak serum and intestinal antibody responses to Vibrio cholerae soluble hemagglutinin in cholera patients.
A soluble hemagglutinin/protease from Vibrio cholerae has been suggested to be a putative virulence factor and protective antigen. However, clinical cholera infection gave rise to detectable serum antibody responses to soluble hemagglutinin in only 2 of 10 Bangladeshi patients or 1 of 17 cholera-infected North American volunteers. A gut mucosal immunoglobulin A antibody response to soluble hemagglutinin was seen in 4 of 8 Bangladeshi patients, but in 0 of 10 North American volunteers. These responses were much weaker than those to cholera toxin or lipopolysaccharide.
D000293:Adolescent; D000328:Adult; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D001459:Bangladesh; D002648:Child; D002675:Child, Preschool; D002771:Cholera / Q000276:immunology*; D006388:Hemagglutinins / Q000276:immunology*; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000276:immunology; D007422:Intestines / Q000276:immunology; D008875:Middle Aged; D009656:North America; D013548:Sweden; D014734:Vibrio cholerae / Q000276:immunology*
D000907:Antibodies, Bacterial; D006388:Hemagglutinins; D007071:Immunoglobulin A, Secretory