Localization and function of myocardial lipolysis.
Mobilization of triacylglycerol stored in heart cells is accomplished by the combined action of lysosomal (acid) lipase and microsomal monoacylglycerol lipase or carboxylesterase. Non(heparin)-releasable neutral or alkaline lipase is similar to non(readily)-releasable lipoprotein lipase (LPL). The enzyme is mainly localized extracellularly. Non(readily)-releasable LPL probably represents LPL in caveola or vacuolae of vascular endothelium and/or LPL on myocardial interstitium. It contributes to the uptake of lipoprotein constituents in heart cells. Glycerol, an endproduct of lipolysis, is not a reliable marker for the net mobilization of lipid stored in heart cells. It is formed both intra- and extracellularly, and does not reflect the rate of oxidation of part of free fatty acids formed.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D005110:Extracellular Space / Q000201:enzymology; D005990:Glycerol / Q000378:metabolism; D008049:Lipase / Q000378:metabolism; D008066:Lipolysis; D008071:Lipoprotein Lipase / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology; D008854:Microscopy, Electron; D008861:Microsomes / Q000201:enzymology; D008994:Monoacylglycerol Lipases / Q000378:metabolism; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D014280:Triglycerides / Q000378:metabolism
D014280:Triglycerides; D008994:Monoacylglycerol Lipases; D008049:Lipase; D008071:Lipoprotein Lipase; D005990:Glycerol; D002118:Calcium