On induced fragmentation of ovarian oocytes.
Fragmentation of oocytes was induced in the ovary, via ovulation suppression, by administration of dehydroepiandrosterone acetate (DHA-Ac) to mature cycling rats. The maximal fragmentation ratio, 15.0 +/- 3.2%, was obtained by 10 mg/100 g b.wt/day for 7-day administration of DHA-Ac. The relationship of fragmentation to the first stage of meiosis is also discussed.
D000818:Animals; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D009865:Oocytes / Q000187:drug effects / Q000502:physiology*; D010060:Ovulation / Q000187:drug effects; D010063:Ovum / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D003687:Dehydroepiandrosterone; C028163:dehydroepiandrosterone acetate