Structure revision and cytotoxicity of the germacranolide, stizolicin, from Stizolophus balsamitus (Asteraceae).
The structure of the cytotoxic sesquiterpene lactone, stizolicin, reisolated from Stizolophus balsamitus (Centaurea b.) was revised to a trans, trans germacranolide (1) on the basis of simultaneous application of lanthanide shift reagent and NOE in the NMR.
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D006801:Humans; D007942:Leukemia, Experimental / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008968:Molecular Conformation; D009369:Neoplasms / Q000473:pathology; D010944:Plants / Q000032:analysis; D012717:Sesquiterpenes / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; C042748:stizolicin