Combination effect of piperacillin with four aminoglycosides on nonfermenting gram-negative bacteria.
The in vitro efficacy of piperacillin in combination with gentamicin, tobramycin, amikacin and netilmicin against 57 nonfermenting gram-negative bacterial strains was compared by use of the checkerboard agar dilution technique. On average 34% of all nonfermenting strains were inhibited by additive, 13% by synergistic piperacillin-amino-glycoside combinations. Great variation occurred between the different bacterial species. Piperacillin-aminoglycoside combinations were most active on Pseudomonas aeruginosa and least potent on Pseudomonas cepacia. Piperacillin was highly active against P. aeruginosa, P. cepacia, Pseudomonas fluorescens-putida and Acinetobacter species.
D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004357:Drug Synergism; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000494:pharmacology*; D010878:Piperacillin
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D010406:Penicillins; D010878:Piperacillin