Uterine stimulant action of some 16-phenoxy analogues of (+)-11-deoxyprostaglandin E1.
Some (+)-11-deoxy-16-phenoxyprostaglandin E1 analogues have been evaluated as uterine stimulants in the anaesthetised pregnant rat. Gastrointestinal side effects, assessed by the antagonism of morphine-induced constipation in the mouse, were relatively low with some of these compounds, six of which had a much more favourable relative selectivity than 16,16-dimethyl-PGE2 methyl ester.
D000527:Alprostadil / Q000031:analogs & derivatives*; D000818:Animals; D004064:Digestive System / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D011247:Pregnancy; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000187:drug effects*
D011459:Prostaglandins E, Synthetic; D009020:Morphine; C032405:11-deoxy-16-phenoxy-17,18,19,20-tetranorprostaglandin E1; D000527:Alprostadil; C034008:11-deoxyprostaglandin E1