[Clinical and experimental animal studies made to determine the influence of topically applied chlorohexidine upon plaque formation, germ flora, and caries production (author's transl)].
A clinical and microbiological study has been made to determine, within a period of four weeks and on a total of ten Soviet schoolchildren, the effects of daily rinses with Polfa, a 0.2% solution of chlorohexidine gluconate, upon plaque formation, plaque flora, and gingival condition within the framework of controlled oral hygiene, with the subjects included in this program being twelve-year-olds. A 20-day experiment on forty Wistar rats was performed with the object of determining the effect of two applications per week of chlorohexidine upon both caries production and oral germ flora. Topical application of chlorohexidine resulted in a marked reduction of plaque formation, substantial improvement in gingival condition, and considerable decrease in the germ content of the plaque. A significant reduction in oral germ count could be determined in the experimental animals. However, it was not possible to observe a significant inhibition of caries production.
D000818:Animals; D002648:Child; D002710:Chlorhexidine / Q000008:administration & dosage*; D004245:DMF Index; D003731:Dental Caries / Q000382:microbiology / Q000517:prevention & control*; D003773:Dental Plaque / Q000382:microbiology / Q000517:prevention & control*; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006801:Humans; D009067:Mouthwashes; D009911:Oral Hygiene Index; D010512:Periodontal Index; D051381:Rats; D013997:Time Factors
D009067:Mouthwashes; D002710:Chlorhexidine
Klinische und tierexperimentelle Untersuchungen üben den Einfluss lokalapplizierten Chlorhexidins auf Plaquebildung, Keimflora und Kariesbefall.