The effect of acute administration of the mycotoxin zearalenone to female pigs.
Crystalline zearalenone was administered to young female pigs at dose levels of 0, 3.5, 7.5 and 11.5 mg zearalenone/kg body weight. All animals receiving the mycotoxin exhibited vulva vaginitis and had enlarged reproductive tracts, 1 week after dosing. Free zearalenone was found in the blood, feces and urine of dosed animals. The highest zearalenone level detected was 2.61 ng/ml from a pig that received the 7.5 mg/kg dose. After 24 hours, feces collected contained on average upto 308 ng zearalenone per g of dried feces. Zearalenone levels of up to 59 ng/ml, and alpha-zearalenol levels of up to 155 ng/ml urine were found. beta-zearalenol was also detected in the urine.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000032:analysis; D005260:Female; D005836:Genitalia, Female / Q000187:drug effects; D009183:Mycotoxins / Q000378:metabolism / Q000633:toxicity*; D012118:Resorcinols / Q000633:toxicity*; D012894:Sleep Stages / Q000187:drug effects; D013552:Swine / Q000378:metabolism*; D014848:Vulvovaginitis / Q000139:chemically induced*; D015025:Zearalenone / Q000378:metabolism / Q000633:toxicity*
D009183:Mycotoxins; D012118:Resorcinols; D015025:Zearalenone