Hodgkin's and non-Hodgkin's lymphomas masquerading as "idiopathic" liver granulomas.
Three patients presented with liver granulomas and fever. An intensive investigation was initially negative. Corticosteroids were administered with dramatic clinical improvement. Ten months to 3 years later, upon tapering the corticosteroid dose, the initial manifestations reappeared. In two patients Hodgkin's lymphoma was discovered and in a third histiocytic lymphoma. Thus, the diagnosis of lymphoma should be considered in patients with idiopathic liver granulomas, fever, and hepatosplenomegaly without lymph node enlargement, who respond initially to steroid administration but relapse upon tapering the dose.
D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D006099:Granuloma / Q000175:diagnosis* / Q000188:drug therapy; D006505:Hepatitis / Q000175:diagnosis* / Q000188:drug therapy; D006689:Hodgkin Disease / Q000175:diagnosis*; D006801:Humans; D008223:Lymphoma / Q000175:diagnosis*; D008297:Male; D011241:Prednisone / Q000627:therapeutic use
D011241:Prednisone