Efficacy of antibodies generated by Pr-beta-hCG-TT to terminate pregnancy in baboons: its reversibility and rescue by medroxyprogesterone acetate.
Antibodies produced by the vaccine Pr-beta-hCG-TT in monkeys were effective in terminating pregnancy in baboons on passive administration. The animals returned to cyclicity soon after the onset of vaginal bleeding. Fertility was regained. Globulins from non-immunized control monkeys in amounts, volume and injection schedule similar to those employed for passive termination did not intercept pregnancy. The abortifacient action of anti-CG antibodies could be counteracted by administration of medroxyprogesterone acetate.
D000028:Abortion, Induced; D000818:Animals; D000917:Antibody Formation; D006063:Chorionic Gonadotropin / Q000097:blood / Q000276:immunology*; D005260:Female; D007116:Immunization, Passive; D008253:Macaca mulatta / Q000276:immunology; D008525:Medroxyprogesterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017258:Medroxyprogesterone Acetate; D010215:Papio / Q000276:immunology*; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D013745:Tetanus Toxoid / Q000276:immunology*
D006063:Chorionic Gonadotropin; D013745:Tetanus Toxoid; D011374:Progesterone; D017258:Medroxyprogesterone Acetate; D008525:Medroxyprogesterone