Chronic active hepatitis in mice induced by 3-hydroxy-4-pyrone.
Chronic active hepatitis was selectively induced in mice by the feeding of a diet containing 3-hydroxy-4-pyrone (0.5% by weight) for periods of 6 weeks and longer. This model should be of particular value in elucidating the pathogenesis of drug-induced forms of chronic active hepatitis. Maltol (3-hydroxy-2-methyl-4-pyrone) did not produce any liver lesion.
D000818:Animals; D056487:Chemical and Drug Induced Liver Injury, Chronic; D002867:Chromones / Q000008:administration & dosage; D004032:Diet; D004195:Disease Models, Animal; D005260:Female; D006521:Hepatitis, Chronic / Q000473:pathology; D008099:Liver / Q000473:pathology; D051379:Mice
D002867:Chromones; C030415:pyromeconic acid