Six blind men explore an elephant: aspects of fuel metabolism and the control of tricarboxylic acid cycle activity in heart muscle.
Many aspects of the interactions of energy providing substrates and the operational control of the tricarboxylic acid cycle are still unclear. This statement is well supported by the sometimes conflicting observations in heart muscle. The paper discusses some of the knowns and unknowns of tricarboxylic acid cycle regulation and discusses mechanisms of metabolite accumulation in this tissue. It is concluded that the data available at this time are insufficient to propose a unifying concept.
D000105:Acetyl Coenzyme A / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002950:Citrate (si)-Synthase / Q000378:metabolism; D002952:Citric Acid Cycle; D004734:Energy Metabolism; D005227:Fatty Acids / Q000378:metabolism; D006801:Humans; D008929:Mitochondria, Heart / Q000201:enzymology; D009206:Myocardium / Q000201:enzymology*; D010088:Oxidoreductases / Q000378:metabolism; D010101:Oxygen Consumption
D001786:Blood Glucose; D005227:Fatty Acids; D000105:Acetyl Coenzyme A; D000255:Adenosine Triphosphate; D010088:Oxidoreductases; D002950:Citrate (si)-Synthase