Lymphoblastic lymphoma with convoluted nuclei. A report of 19 cases.
A clinically homogeneous population of patients who presented with lymphoblastic lymphoma of convoluted nuclear type was isolated using a histopathological criterion that can easily be applied by trained pathologists. This disease type preferentially affects young male patients, in over half of whom there is initial mediastinal involvement. There is a tendency for the disease to become leukemic and to invade the central nervous system. In spite of heavy chemotherapy and early neuromeningeal prophylaxis, the prognosis is poor.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002467:Cell Nucleus / Q000473:pathology*; D002648:Child; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007938:Leukemia / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology*; D008223:Lymphoma / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy / Q000517:prevention & control / Q000532:radiotherapy; D008875:Middle Aged; D011379:Prognosis; D013736:Testicular Neoplasms / Q000473:pathology; D013997:Time Factors