Intra HLA-D region recombinant maps HLA-DR between HLA-B and HLA-D.
A consanguineous family has been typed for HLA-A, B, C, D, DR and GLO, Bf, C2 and C4 and other red cell markers. The results indicate that an expected Dw7 homozygous sibling is a "Dw1"/Dw7 recombinant, probably derived from a crossing over between DR and D on the paternal haplotypes. The anomalous typings by Dw1 HTCs of the recombinant haplotype are best explained by the likely presence of an additional Lad polymorphism which could be a serologically detectable second epitope on the same molecule as the HLA-D determinant or in the form of two linked chains, one encoded by HLA-D and one by another Lad gene in the HLA haplotype.
D001788:Blood Grouping and Crossmatching; D003175:Complement C2 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D011415:Complement Factor B / Q000032:analysis; D003241:Consanguinity; D003434:Crossing Over, Genetic; D005260:Female; D005455:Fluorescent Antibody Technique; D005838:Genotype; D006680:HLA Antigens / Q000032:analysis / Q000235:genetics*; D006801:Humans; D007791:Lactoylglutathione Lyase / Q000032:analysis; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D010375:Pedigree; D011995:Recombination, Genetic
D003175:Complement C2; D003181:Complement C4; D006680:HLA Antigens; D011415:Complement Factor B; D007791:Lactoylglutathione Lyase