Hypernatraemic dehydration revisited.
After discussing earlier concepts of hypernatraemic dehydration, experiments on infantile mini-pigs are reported. After giving osmolar NaCl and NH4Cl solution, dehydration with chloride acidosis was produced and then rehydration was started for 24 h. From the findings the conclusion was drawn that in hypernatraemic dehydration cerebral lesions are not primarily due to an overall impairment of brain blood flow and that blood pressure is a misguiding criterion of fluid loss and circulatory assessment.
D000818:Animals; D001794:Blood Pressure; D001921:Brain / Q000098:blood supply; D003681:Dehydration / Q000209:etiology* / Q000503:physiopathology; D004195:Disease Models, Animal; D006955:Hypernatremia / Q000150:complications*; D013552:Swine; D013556:Swine, Miniature