Glucocorticoid-induced cleft palate genes in chromosome 17: genetic linkage and mapping analyses.
Genes that influence susceptibility to dexamethasone-induced cleft palate and tentatively designated Dep are linked to the major histocompatibility complex H-2 in chromosome 17 of the mouse. Experiments presented refine the map of genes. The results show two or three Dep loci. The two-locus model maps Dep genes to the class II gene E beta and to the chromosomal region between the S and D genes. The three-locus model maps the Dep genes to the chromosomal regions from the centromere to E beta, from E beta to S, and from D to Pgk-2. Experiments were done by comparing the dexamethasone-induced cleft palate dose response of congenic strains with H-2 haplotypes that are recombinants of H-2a and H-2b. The analysis of genetic linkage between H-2 and Dep was expanded to include reciprocal backcrosses. A maternal factor was found to influence the frequency of dexamethasone-induced cleft palate in the backcross fetuses. The factor's origin is associated with the H-2 haplotype of the outcross mother, so the effect is actually a "grandmother effect" that probably is transmitted horizontally. Finally, the sexes were distributed unevenly between the fetuses with cleft palate in two of the congenic strains. This suggests interaction between the H-2-linked Dep genes and a Dep sex-associated gene that modulates susceptibility to dexamethasone-induced cleft palate.
D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D002972:Cleft Palate / Q000139:chemically induced / Q000235:genetics*; D003433:Crosses, Genetic; D003907:Dexamethasone / Q000633:toxicity*; D005260:Female; D005327:Fetal Resorption; D005333:Fetus; D005787:Gene Frequency; D005796:Genes; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics*; D008285:Major Histocompatibility Complex; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D011247:Pregnancy; D013045:Species Specificity
D006183:H-2 Antigens; D003907:Dexamethasone