[Hodgkin's disease complicated with autoimmune thrombocytopenic purpura and a nephrotic syndrome due to deposition of circulating immunocomplexes (author's transl)].
This report deals with a case of Hodgkin's disease presenting during its evolution with autoimmune thrombocytopenic purpura and a nephrotic syndrome with extramembranous glomerulonephritis. The histopathological study of renal tissue demonstrated the presence of IgG and the C3 fraction of complement in the extramembranous deposits. The same type of immunoglobulins and C3 existed in the serum as circulating immunocomplexes, suggesting that the glomerulonephritis was due to the deposition of such immunocomplexes in the glomerular membrane. A review of the literature discloses 32 cases of autoimmune thrombocytopenic purpura associated to Hodgkin's lymphoma, and 47 cases of Hodgkin's lymphoma associated to the nephrotic syndrome. However, the association of both complications in the same patient with lymphoma has been heretofore unreported. The possible etiopathogenic mechanisms of these autoimmune complications and its pathological features are discussed along with the response to treatment. Generally the activity of such disorders parallels that of the lymphoma, thus making them potentially useful parameters to appraise lymphomatous activity.
D000328:Adult; D001706:Biopsy; D003176:Complement C3 / Q000032:analysis; D005921:Glomerulonephritis / Q000209:etiology / Q000276:immunology; D006689:Hodgkin Disease / Q000150:complications / Q000276:immunology*; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology*; D007074:Immunoglobulin G / Q000032:analysis; D007668:Kidney / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000209:etiology* / Q000276:immunology; D011696:Purpura, Thrombocytopenic / Q000209:etiology* / Q000276:immunology
D003176:Complement C3; D007074:Immunoglobulin G
Enfermedad de Hodgkin complicada con púrpura trombopénica autoimmune y síndrome nefrótico por depósito de immunocomplejos circulantes.