Various colony-formers of Mycobacterium avium-intracellulare.
Four disease-associated strains of Mycobacterium avium-intracellular isolated in our laboratory from human sputum gave rise to transparent, opaque, intermediate, and rough colony forms on cornmeal glycerol medium. Each colony-former was purified, and both the virulence to conventional ddY strain of mice and in vitro susceptibilities to various antimicrobial drugs were compared among different colony-formers. The opaque colony-formers were more susceptible to cephalothin, rifampicin, gentamicin, tobramycin, and kanamycin than the other colony-formers. Simultaneous evaluation of virulence to the mice revealed both opaque and intermediate colony-formers to be less virulent than transparent and rough colony-formers.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000502:physiology*; D009162:Mycobacterium avium / Q000472:pathogenicity / Q000502:physiology*; D013234:Stem Cells / Q000145:classification* / Q000187:drug effects
D000900:Anti-Bacterial Agents