[Effect of methionine, retinol, tocopherol and pyridoxine on fibrogenesis in the lungs and vitamin metabolism in rats in an anthracosis model].
It has been discovered in rat experiments that the diet containing an additional amount of methionine and pyridoxine and optimal quantity of fat favoured to a certain degree the retardation of the development of pulmonary fibrosis and reduced the disorders in metabolism of vitamins, characteristic for animals with experimental anthracosis. On the contrary, introduction of an additional amount of retinol into the above complex aggravated the development of pulmonary fibrosis and alterations in vitamin metabolism. At the same time the negative manifestations seen in the animals with experimental anthracosis were removed to a certain measure by administering additional doses of vitamin E.
D000818:Animals; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D008297:Male; D008715:Methionine / Q000627:therapeutic use*; D011009:Pneumoconiosis / Q000188:drug therapy* / Q000378:metabolism; D011658:Pulmonary Fibrosis / Q000378:metabolism / Q000517:prevention & control*; D011736:Pyridoxine / Q000627:therapeutic use*; D051381:Rats; D014801:Vitamin A / Q000627:therapeutic use*; D014810:Vitamin E / Q000627:therapeutic use*; D014815:Vitamins / Q000378:metabolism*
D014815:Vitamins; D014801:Vitamin A; D014810:Vitamin E; D008715:Methionine; D011736:Pyridoxine
Vliianie metionina, retinola, tokoferola i piridoksina na fibrogenez v legkikh i metabolizm vitaminov u krys s model'iu antrakoza.