Pharmacokinetics of mezlocillin during haemodialysis.
The pharmacokinetics of mezlocillin was studied in six patients with end stage renal failure. They were given 2.0 g mezlocillin intravenously both during and without haemodialysis. The mean serum half-life was 2.1 h off dialysis and 1.2 h on dialysis. The distribution volumes were of the same order with and without dialysis. While the patients are on haemodialysis, dosage may be as in patients with normal renal function. Only very minor or no dosage adjustments in relation to normal dosage appear necessary for mezlocillin when the patients are not on dialysis.
D000328:Adult; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008802:Mezlocillin; D010406:Penicillins / Q000378:metabolism*; D006435:Renal Dialysis
D010406:Penicillins; D008802:Mezlocillin