Direction of bacteriophage lambda DNA replication in a thymine requiring Escherichia coli K-12 strain. Effect of thymidine concentration.
The direction of replication was established for the first round of bacteriophage lambda DNA replication in thymine requiring E. coli K-12 cells exposed to different concentrations of thymidine. It was found that a dramatic decrease in the proportion of bidirectionally replicating molecules followed a decrease in the concentration of thymidine. Moreover, the rightward mode of replication appears to be exclusively favored in unidirectionally replicating molecules found at low concentrations of thymidine.
D010582:Bacteriophage lambda / Q000187:drug effects* / Q000378:metabolism; D004261:DNA Replication / Q000187:drug effects*; D004279:DNA, Viral / Q000096:biosynthesis; D004926:Escherichia coli / Q000378:metabolism; D013936:Thymidine / Q000494:pharmacology*; D013941:Thymine / Q000378:metabolism
D004279:DNA, Viral; D013941:Thymine; D013936:Thymidine