Effect of D,L-propargylglycine on cystathionine metabolism in rats.
Hepatic gamma-cystathionase activity at 12 h after the intraperitoneal injection decreased in proportion to the amount of D,L-propargylglycine administered, but hepatic cystathionine beta-synthase activity did not change. Contents of cystathionine in the liver increased gradually from 0.25 mg to 30 mg/200 g body weight in proportion to the amounts of D,L-propargylglycine injected; in the kidney, 0.5 mg to 10 mg; in the brain, 5 mg to 20 mg; in the serum, 0.25 mg to 30 mg. Contents of N-acetylcystathionine in the liver and kidney also increased in parallel with the accumulation of cystathionine.
D000480:Alkynes / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism; D003540:Cystathionine / Q000378:metabolism*; D003542:Cystathionine gamma-Lyase / Q000378:metabolism*; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008190:Lyases / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000480:Alkynes; D003540:Cystathionine; C009055:propargylglycine; D008190:Lyases; D003542:Cystathionine gamma-Lyase; D005998:Glycine