Fibrosarcoma complicating irradiated pituitary adenoma.
Eight years after radiation therapy (5000 rads of 60Co) for a pituitary adenoma, a patient developed a sellar fibrosarcoma. The tumor had an aggressive growth pattern: it infiltrated the optic nerve, sphenoidal air sinus, hypothalamus, and both cavernous sinuses, where compression of the left internal carotid artery resulted in a massive hemispheric infarction. Surgery was ineffective in arresting rapid growth of the lesion; death occurring 5 months after onset of symptoms.
D000238:Adenoma, Chromophobe / Q000532:radiotherapy*; D003037:Cobalt Radioisotopes / Q000009:adverse effects*; D005354:Fibrosarcoma / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D010911:Pituitary Neoplasms / Q000532:radiotherapy*; D011867:Radioisotope Teletherapy / Q000009:adverse effects*; D012658:Sella Turcica / Q000473:pathology; D012888:Skull Neoplasms / Q000209:etiology* / Q000473:pathology; D013997:Time Factors
D003037:Cobalt Radioisotopes