Demonstration of antibody and cellular immune response to brain extract in West and Lennox-Gastaut syndromes.
We investigated humoral and cellular immune response to brain tissues in 15 patients with West syndrome, in 9 patients with Lennox-Gastaut syndrome and in 20 healthy children. High levels of a precipitating antibody to a saline extract of brain tissue were detected in all patients; leucocyte migration inhibition test with the same antigen was found to be positive in most of them. The role of this autoimmune response in the pathogenesis of West and Lennox-Gastaut syndromes remains to the elucidated.
D000293:Adolescent; D000906:Antibodies / Q000276:immunology*; D000917:Antibody Formation; D001921:Brain / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000150:complications / Q000276:immunology*; D005260:Female; D006429:Hemiplegia / Q000150:complications / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007223:Infant; D008297:Male; D013036:Spasms, Infantile / Q000276:immunology*; D013577:Syndrome; D014020:Tissue Extracts / Q000276:immunology*
D000906:Antibodies; D014020:Tissue Extracts