Inhibition of 12-O-tetradecanoylphorbol-13-acetate-stimulated 3-O-methyl-glucose transport in mouse Swiss 3T3 fibroblasts by glycyrrhetic acid.
12-O-Tetradecanoylphorbol-13-acetate (TPA), a potent tumor promoter, stimulated 3-O-methyl-glucose (3MeGlu) transport in Swiss 3T3 mouse fibroblasts. Application of glycyrrhetic acid, a terpenoid derivative, to cells prior to the treatment with TPA showed a time- and dose-dependent inhibitory effect on the TPA-stimulated 3MeGlu transport. From the kinetic analysis, it was suggested that the TPA-induced stimulation of hexose transport was due to the enhancement of the number of hexose carrier, which was completely inhibited by glycyrrhetic acid.
D019325:3-O-Methylglucose; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001693:Biological Transport, Active / Q000187:drug effects; D002478:Cells, Cultured; D004622:Embryo, Mammalian; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D019695:Glycyrrhizic Acid; D007700:Kinetics; D008757:Methylglucosides / Q000378:metabolism*; D008759:Methylglycosides / Q000378:metabolism*; D051379:Mice; D010704:Phorbols / Q000494:pharmacology*; D013729:Terpenes / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D000998:Antiviral Agents; D008757:Methylglucosides; D008759:Methylglycosides; D010704:Phorbols; D013729:Terpenes; D019325:3-O-Methylglucose; D019695:Glycyrrhizic Acid; D013755:Tetradecanoylphorbol Acetate; D006034:Glycyrrhetinic Acid