Regulation of Mn-SOD activity in the mouse heart: glucose effect.
Intraperitoneal injection of glucose was found to cause a dose and time dependent suppression of superoxide dismutase activity in mouse heart. Manganese superoxide dismutase was more sensitive to glucose suppression than Cu-Zn superoxide dismutase. While glucose suppressed the Mn form of the enzyme at the concentration of 1.5 mg/kg, it did not have a significant effect on Cu-Zn superoxide dismutase activity at this concentration. The maximum suppression for both forms of superoxide dismutase activity occurred at 4.5 mg/kg. Glucose also suppressed manganese superoxide dismutase activity in mouse heart for a longer period of time compared to Cu-Zn superoxide dismutase. Glucose suppression also occurred in mouse brain. The glucose suppression effect on manganese superoxide dismutase activity in the heart was partially alleviated by X-irradiation.
D000818:Animals; D005260:Female; D005947:Glucose / Q000494:pharmacology*; D006321:Heart / Q000528:radiation effects; D007700:Kinetics; D051379:Mice; D009206:Myocardium / Q000201:enzymology*; D013482:Superoxide Dismutase / Q000378:metabolism* / Q000528:radiation effects
D013482:Superoxide Dismutase; D005947:Glucose