On the mechanism of action of anesthetics. Direct inhibition of mitochondrial F1-ATPase by n-butanol and tetracaine.
The concentrations of n-butanol and tetracaine required for 50% inhibition of the ATPase activity of F1 particles isolated from bovine heart mitochondria were 160 mM and 1.1 mM, respectively. The results are offered as evidence that the physiological effects of these anesthetics may be due to direct interaction with membrane proteins rather than with the lipids.
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000779:Anesthetics, Local; D000818:Animals; D000440:Butanols / Q000494:pharmacology*; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D008929:Mitochondria, Heart / Q000201:enzymology*; D006180:Proton-Translocating ATPases; D013748:Tetracaine / Q000494:pharmacology*
D000779:Anesthetics, Local; D000440:Butanols; D013748:Tetracaine; D000251:Adenosine Triphosphatases; D006180:Proton-Translocating ATPases