Effect of zinc ions on farnesyl pyrophosphate synthetase activity.
Farnesyl pyrophosphate synthetases from pig and avian livers exhibit higher catalytic activities in the presence of 0.2 mM ZnCl2 than in the presence of MgCl2 or MnCl2 which are known to be required for enzyme activity. This is not the case for isopentenyl pyrophosphate isomerase or squalene synthetase.
D000818:Animals; D002413:Cations, Divalent; D002645:Chickens; D002712:Chlorides; D003600:Cytosol / Q000201:enzymology; D004122:Dimethylallyltranstransferase / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008274:Magnesium / Q000494:pharmacology; D015636:Magnesium Chloride; D008345:Manganese / Q000494:pharmacology; D017895:Manganese Compounds; D008862:Microsomes, Liver / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D013045:Species Specificity; D013552:Swine; D014166:Transferases / Q000378:metabolism*; D015032:Zinc / Q000494:pharmacology*; D017967:Zinc Compounds
D002413:Cations, Divalent; D002712:Chlorides; D017895:Manganese Compounds; D017967:Zinc Compounds; D015636:Magnesium Chloride; D008345:Manganese; C016837:zinc chloride; D014166:Transferases; D004122:Dimethylallyltranstransferase; D008274:Magnesium; D015032:Zinc; C025340:manganese chloride