[Ultrastructural changes in the components of the filtration barrier in the glomerular capillaries of a remaining kidney following its temporary ischemia].
The components of the filtration barrier of the glomerular capillaries of the rat remaining kidney were studied ultrastructurally 3, 7, 14, 30, 60, 180 and 360 days after exposure to 30 minutes and to 1-2 hours of ischemia. Submicroscopic changes found in the glomerular capillaries and in compensation -adaptive processes occurring in the remaining kidney were ascertained to be dependent on the duration of ischemia and the time elapsed since recirculation in the kidney. After 30-minute ischemia experienced by the remaining kidney the structural alterations in the glomerular capillaries were not remarkable, disappearing 14 days following recirculation, with the emergence by that time of the signs of hyperplasia and hypertrophy of intracellular structures. After raising the time of temporary ischemia of the remaining kidney up to 60 min followed by recirculation, appreciable ultrastructural postischemic disorders were recorded in the components of the filtration barrier of the glomerular capillaries. In addition, the compensation-adaptive processes in the kidney remained suppressed for a longer period of time. All these disorders were particularly demonstrable as a result of 2-hour ischemia. It was also discovered that destructive processes dominated over reparative ones thereby leading to the animals' death at early times of experiment.
D000818:Animals; D002196:Capillaries / Q000648:ultrastructure; D002199:Capillary Permeability; D007511:Ischemia / Q000473:pathology*; D007668:Kidney / Q000098:blood supply*; D007678:Kidney Glomerulus / Q000098:blood supply*; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains
Ul'trastrukturnye izmeneniia komponentov fil'tratsionnogo bar'era klubochkovykh kapilliarov ostavsheĭsia pochki posle ee vremennoĭ ishemii.