[The influence of climatic treatment on INT-reductase activity in leukocytes of patients with asthma bronchiale (author's transl)].
The mean values of INT-reductase in nonstimulated (nonphagocytising) polymorphs as well as in polymorphs stimulated by zymosan were higher in patients with asthma bronchiale than in a group of clinically healthy volunteers of the same age. The activities of INT-reductase in the leukocytes of patients with asthma bronchiale decreased during a climatic treatment in the high mountain conditions of Strbské Pleso (altitude 1,350 m) and after 3-5 weeks of treatment they reached the normal values ascertained in healthy volunteers. When the climatic treatment ended and the patients returned back to Bratislava, the ability of their leukocytes to reduce INT gradually increased to the levels which were found before the treatment. The changes in the activity of INT-reductase are statistically significant and may be used as an objective criterion for the control of climatic treatment and for its rational dosage.
D000328:Adult; D001249:Asthma / Q000201:enzymology* / Q000628:therapy; D002980:Climate; D006801:Humans; D007962:Leukocytes / Q000201:enzymology*; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D010587:Phagocytosis
D009247:NADH, NADPH Oxidoreductases; C028796:iodophenyl-nitrophenyl-phenyltetrazolium reductase
Einfluss der klimatischen Behandlung auf die INT-Leukozytenreduktaseaktivität bei Patienten mit Asthma bronchiale.