Resolution of pulmonary inflammation.
Mononuclear phagocytes are suggested to play a major orchestrating role in the resolution of inflammatory processes in the lung. Particular emphasis is placed on their participation in the progression from a lesion with neutrophils as the dominant infiltrating cell to one that contains macrophages, on the macrophage's role in removing neutrophils and cell debris, and on their promotion of repair mechanisms. It is suggested that monocytes must mature into macrophages before they are capable of active participation in the resolution of inflammation.
D000818:Animals; D002454:Cell Differentiation; D003182:Complement C5; D015936:Complement C5a; D007249:Inflammation / Q000503:physiopathology; D008264:Macrophages / Q000502:physiology*; D008854:Microscopy, Electron; D009000:Monocytes / Q000502:physiology*; D009504:Neutrophils / Q000502:physiology; D010587:Phagocytosis; D011014:Pneumonia / Q000473:pathology / Q000503:physiopathology*; D011650:Pulmonary Alveoli / Q000503:physiopathology*; D011817:Rabbits
D003182:Complement C5; D015936:Complement C5a