The characterization and function of human immunoregulatory T lymphocyte subsets.
Functional T lymphocyte subpopulations can be identified in humans by antibodies which detect stable glycoprotein antigens on their surface. Thus, inducer T lymphocytes bear an antigen termed T4 while suppressor T lymphocytes bear an antigen termed T5. Immune homeostasis results from a delicate balance between inducer and suppressor subsets within the T-cell circuit and perturbation in subset dynamics may initiate a wide variety of immunopathological disorders. Here Ellis Reinherz and Stuart Schlossman discuss the present understanding of this circuit, its role in the pathogenesis of a number of diseases, and how the human immune response can be manipulated in an orderly way through modulation of selected T-cell subsets.
D000941:Antigens; D001327:Autoimmune Diseases / Q000097:blood; D002454:Cell Differentiation; D002470:Cell Survival; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007154:Immune System Diseases / Q000097:blood; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes / Q000097:blood; D007167:Immunotherapy / Q000379:methods; D007375:Interleukin-1; D008213:Lymphocyte Activation; D008232:Lymphoproliferative Disorders / Q000097:blood; D011506:Proteins / Q000502:physiology; D013601:T-Lymphocytes / Q000145:classification / Q000502:physiology*; D050378:T-Lymphocytes, Regulatory / Q000502:physiology
D000941:Antigens; D007375:Interleukin-1; D011506:Proteins