Effects of oxytetracycline in propylene glycol, oxytetracycline in saline solution, and propylene glycol alone on blood ionized calcium and plasma total calcium in sheep.
Intravenous injection of oxytetracycline HC1 (OTC) in propylene glycol (PG), OTC in saline solution, and PG alone in sheep had no significant (P less than 0.01) effects on total plasma calcium concentrations over a 60-minute period. In contrast, ionized calcium concentrations in whole blood were significantly (P less than 0.01) depressed for approximately 3 minutes after OTC in PG and OTC in saline solution, IV. A slight depression of ionized calcium concentrations was noticed after injection of PG alone. Seemingly, calcium chelation by OTC may be a major factor in the collapse syndrome of ungulates given preparations containing OTC by rapid IV injection.
D000818:Animals; D002118:Calcium / Q000097:blood*; D005260:Female; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D010118:Oxytetracycline / Q000008:administration & dosage / Q000494:pharmacology*; D014677:Pharmaceutical Vehicles; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000008:administration & dosage / Q000494:pharmacology*; D012756:Sheep / Q000097:blood*; D012965:Sodium Chloride / Q000008:administration & dosage
D014677:Pharmaceutical Vehicles; D011409:Propylene Glycols; D012965:Sodium Chloride; D019946:Propylene Glycol; D002118:Calcium; D010118:Oxytetracycline