The cholecystokinin antagonist, proglumide, increases food intake in the rat.
Cholecystokinin, secreted in response to ingested food entering the duodenum, may play a role in limiting food intake. Inhibition of cholecystokinin should therefore induce an increase in food intake. Proglumide, a specific antagonist of cholecystokinin was used to block the satiety effect of a food preload in rats. A significant increase in food intake was obtained following proglumide injection, thus supporting the hypothesis that cholecystokinin, released by food in the duodenum, acts as a short-term satiety factor.
D000818:Animals; D001066:Appetite / Q000187:drug effects*; D002766:Cholecystokinin / Q000037:antagonists & inhibitors*; D002149:Energy Intake; D005215:Fasting; D005973:Glutamine / Q000031:analogs & derivatives*; D006815:Hunger / Q000187:drug effects; D008297:Male; D011377:Proglumide / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D005973:Glutamine; D002766:Cholecystokinin; D011377:Proglumide