The effect of chlorpromazine on pharmacokinetics and pharmacodynamics of phenobarbital in X-irradiated rats.
Male Wistar rats were irradiated with a single 600R dose of X-rays on the whole body. Chlorpromazine was given 30 min before phenobarbital. Phenobarbital sleeping time was prolonged by chlorpromazine both in irradiated and non-irradiated rats. On the 3rd day after irradiation the prolongation of the phenobarbital sleep by chlorpromazine was more marked than on the 6th day. No correlation between the pharmacodynamic action of phenobarbital and its cerebral level was noted.
D000818:Animals; D001711:Biotransformation / Q000187:drug effects / Q000528:radiation effects; D001921:Brain / Q000378:metabolism; D002746:Chlorpromazine / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D010634:Phenobarbital / Q000378:metabolism* / Q000494:pharmacology; D011827:Radiation; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects; D014018:Tissue Distribution / Q000187:drug effects / Q000528:radiation effects
D002746:Chlorpromazine; D010634:Phenobarbital