Nortriptyline and debrisoquine hydroxylations in Ghanaian and Swedish subjects.
Eleven Ghanaian and 12 Swedish subjects phenotyped with a debrisoquine (D) hydroxylation test were given a single oral dose of nortriptyline (NT). Much the same percentage of the given NT dose was excreted as 10-hydroxy-NT (10-OH-NT) by Ghanaians (43.1%) and Swedes (49.2%). There was a close correlation between plasma clearance of NT by 10-hydroxylation and the D metabolic ratio (D/4-OH-D in urine) in the Ghanaians (rs = -0.95; P less than 0.01) and Swedes (rs = -0.84; P less than 0.01). The E-isomer of 10-OH-NT is the major isomer in both Ghanaians (76% to 92% of total 10-OH-NT) and Swedes (78% to 95%). It is suggested that the E-10-hydroxylation of NT and the 4-hydroxylation of D are similarly coregulated in Ghanaians and Swedes.
D000284:Administration, Oral; D000328:Adult; D003647:Debrisoquin / Q000097:blood / Q000378:metabolism*; D005260:Female; D005869:Ghana; D006801:Humans; D006900:Hydroxylation; D007546:Isoquinolines / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009661:Nortriptyline / Q000097:blood / Q000378:metabolism* / Q000652:urine; D010641:Phenotype; D013548:Sweden / Q000208:ethnology
D007546:Isoquinolines; D009661:Nortriptyline; D003647:Debrisoquin