Alteration of lidocaine- or procaine-induced convulsions by manipulation of brain amines.
Lidocaine and procaine seizure thresholds were studied. The i.p. median convulsant dose (CD50) of lidocaine and procaine with saline pre-treatment was 95 and 240 mg/kg, respectively. Dopamine depletion by pre-treatment with d1-alpha-methyl-p-tyrosine plus dihydroxyphenylserine resulted in a significant drop of CD50 to 69 and 175 mg/kg for lidocaine and procaine, respectively. Serotonin depletion by pre-treatment with p-chlorophenylalanine resulted in a significant drop of CD50 to 68 mg/kg for lidocaine, but no significant change for procaine.
D000818:Animals; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide / Q000494:pharmacology; D001921:Brain / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D015103:Droxidopa / Q000494:pharmacology; D010134:Fenclonine / Q000031:analogs & derivatives / Q000494:pharmacology; D008012:Lidocaine / Q000009:adverse effects*; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D011343:Procaine / Q000009:adverse effects*; D051381:Rats; D012640:Seizures / Q000139:chemically induced* / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D014191:Tranylcypromine / Q000494:pharmacology
D008781:Methyltyrosines; D005406:Bis(4-Methyl-1-Homopiperazinylthiocarbonyl)disulfide; D012701:Serotonin; C028490:4-chlorophenylalanine ethyl ester; D014191:Tranylcypromine; C022260:alpha-methyltyrosine methyl ester; D011343:Procaine; D008012:Lidocaine; D015103:Droxidopa; D010134:Fenclonine; D004298:Dopamine; D009638:Norepinephrine