[Efficacy of intrapleural treatment with aclacinomycin combined with closed tube thoracostomy for malignant pleural effusion].
Intrapleural treatment with aclacinomycin combined with closed tube thoracostomy was used in 7 patients with malignant pleural effusion. Five patients had no recurrence of effusion 3 months after the treatment. Aclacinomycin levels were much higher in blood cells than in plasma, and metabolites were present as the active form. We posit that the local instillation of aclacinomycin is indicated in the management of malignant pleural effusion.
D015250:Aclarubicin / Q000031:analogs & derivatives*; D000230:Adenocarcinoma / Q000150:complications*; D000328:Adult; D000368:Aged; D004322:Drainage / Q000379:methods*; D005260:Female; D006801:Humans; D007440:Intubation; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009279:Naphthacenes / Q000008:administration & dosage; D010996:Pleural Effusion / Q000378:metabolism; D013909:Thorax
D009279:Naphthacenes; C011157:aclacinomycins; D015250:Aclarubicin