Semiautomated determination of tridihexethyl chloride in meprobamate tablets.
A semiautomated method has been developed for the analysis of tablets containing tridihexethyl chloride in combination with meprobamate. The method is based on the USP assay for tridihexethyl chloride in tablets. The active ingredient is dissolved in water, the aqueous solution is mixed with buffer and dye solution, and the dye complex is extracted into chloroform. The absorbance of the chloroform solution is monitored at 408 nm. Results from the semiautomated method agree with results for the USP method. Recoveries from authentic formulations show no interference from the excipients tested.
D001322:Autoanalysis / Q000295:instrumentation; D055598:Chemical Phenomena; D002621:Chemistry; D008620:Meprobamate / Q000032:analysis*; D000644:Quaternary Ammonium Compounds / Q000032:analysis*; D013607:Tablets / Q000032:analysis
D000644:Quaternary Ammonium Compounds; D013607:Tablets; C005386:tridihexethyl; D008620:Meprobamate