Bronchospasm induced by vanillin and lactose.
Bronchospasm caused by vanillin and lactose was detected in controlled double-blind challenge tests in an asthmatic patient. It is recommended that all flavouring agents and dyes should be removed from drugs. Lactose is not a suitable placebo for challenges in asthmatic patients. A better choice is cellulose, which is not resorbed by man.
D001547:Benzaldehydes / Q000009:adverse effects*; D001986:Bronchial Spasm / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000175:diagnosis; D005260:Female; D006801:Humans; D007785:Lactose / Q000009:adverse effects*; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate; D010592:Pharmaceutic Aids / Q000009:adverse effects
D001547:Benzaldehydes; D010592:Pharmaceutic Aids; C100058:vanillin; D007785:Lactose