A new formulation of Tc-99m minimicroaggregated albumin for marrow imaging: comparison with other colloids, In-111 and Fe-59.
The biodistributions of five Tc-99m colloids were compared with the 24-hr distributions of Fe-59 and In-111 in dogs by direct radioassay 1 hr after intravenous injection. One formulation of Tc-99m minmicroaggregated albumin (particle size 30-100 mn), produced the highest marrow concentration, approximately six times that of Tc-99m sulfur colloid, with similar blood, and liver concentrations and a lower splenic uptake. Nevertheless, the best colloid marrow uptake was lower than the 24-hr value for In-11 and much lower than that for Fe-59. The marrow concentration of minimicroaggregated albumin was also higher than that of sulfur colloid in rats at 30 min after injection. The principal disadvantage of Tc-99m antimony sulfide colloid was its slow blood clearance. Clinical evaluation of Tc-99m minimicroaggregated albumin for marrow imaging appears warranted, although its hepatic activity will obscure overlying and immediately adjacent marrow.
D000818:Animals; D001853:Bone Marrow / Q000000981:diagnostic imaging* / Q000378:metabolism; D003102:Colloids; D004285:Dogs; D005260:Female; D006207:Half-Life; D007204:Indium / Q000378:metabolism*; D007504:Iron Radioisotopes / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D010316:Particle Size; D011868:Radioisotopes / Q000378:metabolism; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000378:metabolism*; D013667:Technetium / Q000378:metabolism*; D013668:Technetium Tc 99m Aggregated Albumin; D013678:Technology, Pharmaceutical; D013997:Time Factors; D014018:Tissue Distribution
D003102:Colloids; D007504:Iron Radioisotopes; D011868:Radioisotopes; D012709:Serum Albumin; D013668:Technetium Tc 99m Aggregated Albumin; D007204:Indium; D013667:Technetium