HLA-DR, D recombination in a kidney transplant recipient.
Immunogenetic studies of a consanguineous family revealed discordance in the inheritance pattern of the HLA-D and HLA-DR antigens in one offspring. The findings suggest a recombination between the HLA-D and HLA-DR loci in one of the paternal chromosomes. Results on segregation of B-cell alloantigens. MLC reactivity, and glyoxalase isoenzyme determination map the DR gene between the HLA-B and D loci.
D002874:Chromosome Mapping; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D016030:Kidney Transplantation; D007791:Lactoylglutathione Lyase / Q000235:genetics; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D010375:Pedigree; D011995:Recombination, Genetic
D000949:Histocompatibility Antigens Class II; D007791:Lactoylglutathione Lyase