HLA and rheumatoid arthritis. A study of five families.
Five families with two or more members ill with rheumatoid arthritis were investigated clinically. Tissue typing for HLA A, B, C and D/DR antigens was performed. We could not define may HLA haplotype associated with disease within these families. However, the prevalence of the haplotypes containing HLA-DR4 was high, suggesting a direct relationship between DR4 and increased risk of contracting rheumatoid arthritis.
D001172:Arthritis, Rheumatoid / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006650:Histocompatibility Testing; D006801:Humans; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D010375:Pedigree; D010641:Phenotype
D006680:HLA Antigens; D000949:Histocompatibility Antigens Class II