The effect of pH on electronic spectra of butobendin (Craviten) and its spectrophotometric and spectrofluorometric assay in tablets.
Electronic spectra of butobendin are stable between pH 1.00 and 10.89, but they change with pH in the range 10.89-2.19, due to hydrolysis. Spectrophotometric (in aqueous solution at 212 or 270 nm) and spectrofluorometric (in 1N acetic acid, at 270/368 nm) methods of butobendin assay in tablets were elaborated and found to yield precise and reproducible results.
D000889:Anti-Arrhythmia Agents / Q000032:analysis*; D005029:Ethylenediamines / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D013050:Spectrometry, Fluorescence / Q000379:methods; D013607:Tablets / Q000032:analysis
D000889:Anti-Arrhythmia Agents; D005029:Ethylenediamines; D013607:Tablets; C030706:butobendin