Continuous naloxone infusion in pediatric narcotic overdose.
A 31-month-old girl required constant intravenous (IV) infusion of naloxone hydrochloride to treat codeine-induced respiratory and CNS depression. The infusion rate was 0.4 mg/hr (27 micrograms/kg/hr) over nine hours, without apparent side effects or evidence of toxic effects, for a total naloxone hydrochloride dose of 4.1 mg (280 micrograms/kg). Constant naloxone hydrochloride infusion at an initial rate of 0.4 mg/hr in pediatric narcotic poisoning should be considered if the patient responds inadequately to an initial 0.01-mg/kg bolus, requires repeated administration to reverse narcotic-induced effects, or has ingested long-acting agents. Continuous IV naloxone infusion is a convenient, safe, and effective method to treat narcotic overdose.
D000082:Acetaminophen / Q000506:poisoning; D001143:Arousal / Q000187:drug effects; D002675:Child, Preschool; D003061:Codeine / Q000506:poisoning; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D009270:Naloxone / Q000008:administration & dosage / Q000627:therapeutic use*; D009294:Narcotics / Q000506:poisoning*; D012119:Respiration / Q000187:drug effects
D009294:Narcotics; D000082:Acetaminophen; D009270:Naloxone; D003061:Codeine