Establishment of an albumin-deficient and fatty strain of rats.
An albumin-deficient and fatty strain of rats (AFR) was established from crosses between albumin-deficient rats (NAR) and fatty Zucker rats. AFRs have double homozygous mutant genes (alb/alb, fa/fa). The AFRs are heavier than the fatty Zucker rats and they have enlarged livers and adrenal glands. In addition, AFRs show more severe hyperlipidemia than fatty Zucker rats. This strain of rats may serve as a model of human obesity and hyperlipidemia.
D000822:Animal Husbandry; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006579:Heterozygote; D006720:Homozygote; D006949:Hyperlipidemias / Q000235:genetics; D008297:Male; D009765:Obesity / Q000235:genetics; D051381:Rats; D011922:Rats, Mutant Strains / Q000235:genetics*; D011924:Rats, Zucker / Q000235:genetics*; D012709:Serum Albumin / Q000172:deficiency*
D012709:Serum Albumin