Beneficial influence of matching for D/DR antigens and treatment with cyclosporin-A on kidney graft survival in transfused rhesus monkeys.
The influence of matching for D/DR antigens and treatment with Cyclosporin-A (Cy-A) was investigated in rhesus monkeys given pretransplant blood transfusions. It was observed that the combination of D/DR matching and transfusions led to a higher percentage of animals with prolonged graft survival as well as a better kidney function in the early post-transplant period than was achieved with transfusions alone. Regarding the possible interference of Cy-A with the beneficial blood transfusion effect, it was found that transfused animals given Cy-A had survival times which were as good as those of transfused recipients without Cy-A or, sometimes, even slightly better.
D000818:Animals; D001379:Azathioprine / Q000627:therapeutic use; D001803:Blood Transfusion; D003524:Cyclosporins / Q000627:therapeutic use*; D005260:Female; D006085:Graft Survival; D006648:Histocompatibility; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D016030:Kidney Transplantation; D007959:Lymphocyte Culture Test, Mixed; D008253:Macaca mulatta; D008297:Male; D011239:Prednisolone / Q000627:therapeutic use; D011300:Preoperative Care
D003524:Cyclosporins; D000949:Histocompatibility Antigens Class II; D011239:Prednisolone; D001379:Azathioprine