Central nervous system action of angiotensin during onset of renal hypertension in awake rats.
The increase in arterial pressure and vascular resistance during acute unilateral renal artery stenosis (RSt) in conscious rats is, in part, dependent on elevated neurogenic vascular tone produced by an indirect neural interaction of angiotensin II (ANG II) with the sympathetic nervous system. The present experiments examined whether this interaction occurs within the central nervous system. Conscious rats that had been chronically instrumented with miniaturized Doppler flow probes for measurement of regional vascular resistance were subjected to a 50% reduction in unilateral renal flow with an implanted pneumatic occluder. Arterial pressure increased by 35% after 60 min of RSt. In animals in which the pressor response to intracerebroventricular (icv) ANG II had been eliminated by prior surgical interruption of the "ANG II pressor pathway" in the anterior hypothalamus, the increase in blood pressure following RSt was attenuated by 44% (P less than 0.01). In a second series, a central action of ANG II during acute renal hypertension (RH) was assessed by central ANG II receptor blockade with icv saralasin. Unlike normotensive controls, acutely RH animals responded to saralasin with significant (P less than 0.01) decreases in arterial pressure (-32%) and hindquarters (-26%) and contralateral renal (-9%) resistance. These changes were accentuated (-57% decrease in pressure) in animals made areflexic by prior sinoaortic baroreceptor denervation. Thus activation of the sympathetic nervous system during the early high-renin phase of RH depends significantly on a central action of ANG II. This mechanism may account for some 40-50% of the pressure increase following acute RSt.
D000344:Afferent Pathways / Q000503:physiopathology; D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D002346:Carotid Sinus / Q000503:physiopathology; D002490:Central Nervous System / Q000503:physiopathology*; D003243:Consciousness; D003251:Constriction, Pathologic; D006977:Hypertension, Renal / Q000503:physiopathology*; D007031:Hypothalamus / Q000503:physiopathology; D008297:Male; D009407:Nerve Block; D011311:Pressoreceptors / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D011945:Receptors, Angiotensin / Q000187:drug effects; D012018:Reflex / Q000502:physiology; D012078:Renal Artery Obstruction / Q000503:physiopathology; D012504:Saralasin / Q000494:pharmacology
D011945:Receptors, Angiotensin; D000804:Angiotensin II; D012504:Saralasin