Regeneration of endothelium in knitted and velour dacron vascular grafts in dogs.
Velour Dacron vascular grafts have been developed for clinical use because previous investigations of conventional fabric grafts in animals suggested that fibroblastic ingrowth contributed directly to neoendothelialization. In order to determine whether fibroblastic ingrowth was casually related to regeneration of endothelium in velour grafts, composite grafts of knitted and velour Dacron were used to replace either the carotid arteries or the abdominal aorta in 12 adult dogs and were studied by scanning electron microscopy and light microscopy. Partial or complete endothelialization occurred in all aortic grafts. Regeneration of endothelium was identified in three of six carotid velour grafts but was not observed in carotid knitted grafts. although velour grafts stimulated more aggressive perigraft fibrosis in both carotid and aortic replacement than did knitted grafts, transmural migration of fibroblasts from perigraft tissues was not observed in any specimen. The results of this study do not support a causal relationship between fibroblastic ingrowth and regeneration of endothelium in dogs.
D000818:Animals; D001158:Arteries / Q000502:physiology / Q000601:surgery; D001807:Blood Vessel Prosthesis / Q000295:instrumentation; D004285:Dogs; D004727:Endothelium / Q000502:physiology; D011093:Polyethylene Terephthalates / Q000627:therapeutic use*; D012038:Regeneration
D011093:Polyethylene Terephthalates