[Certain Mechanisms regulating cell renewal in the gastric mucosa in peptic ulcer].
A study was made of the effect of an aqueous extract of human gastric mucosa on the mitotic activity of the surface epithelium of the mouse stomach. The extract was found to exert a statistically significant inhibitory action. An extract from the mucosa of the stomach resected for duodenal ulcer exerted a more pronounced inhibitory action as compared with an extract from the stomach resected for gastric ulcer. This fact may be accounted for by a greater content of mature differentiated cells in duodenal ulcer. Tissue-specific action of gastric chalone is indicated by the absence of mitotic inhibition in the small intestinal mucosa.
D000818:Animals; D003864:Depression, Chemical; D004381:Duodenal Ulcer / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects; D006131:Growth Inhibitors / Q000032:analysis; D006801:Humans; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D013274:Stomach Neoplasms / Q000378:metabolism*; D013276:Stomach Ulcer / Q000378:metabolism*; D014020:Tissue Extracts / Q000494:pharmacology*
D006131:Growth Inhibitors; D014020:Tissue Extracts
O nekotorykh mekhanizmakh reguliatsii kletochnogo obnovleniia v slizistoĭ obolochke zheludka pri iazvennoĭ bolezni.