D-tryptophan-6-LH-RH-at los doses in the treatment of male subfertility.
The aim of this trial was to evaluate the effect of D-TRP-6-LH-RH in patients with idiopathic normogonadotropic oligoasthenozoospermia (I.N.O.). The LH and FSH response to LH-RH before and during treatment was also studied. Seven patients (age 27 to 32 years) with long standing infertility were incorporated. All of them were considered to have I.N.O. on the basis of at least three spermatograms and absence of evidence of other diseases. All patients were treated wtih D-TRP-6-LH-RH (2 microgram i.m. every two days) during 90 days. Control spermatograms were performed at monthly intervals during and after treatment. The responses of LH and FSH to 50 microgram i.v. LH-RH were studied before and after 90 days of treatment. Five of the patients achieved a normalization of the concentration of spermatozoa per ml and of the percentage of forwardly progressive spermatozoa. None of the patients showed inhibition of the response to LH and FSH to LH-RH during treatment. These results differ from others in which larger doses of D-TRP-6-LH-RH determined an inhibition of the pituitary response to LH-RH and an impairment of the spermogram.
D000328:Adult; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009845:Oligospermia / Q000188:drug therapy*; D013076:Sperm Count; D013081:Sperm Motility; D017329:Triptorelin Pamoate
D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone