Acidic lens-protein degrading activity: I. Distribution in bovine ocular tissues.
Bovine lens-protein degradation by ocular tissue homogenates was studied biochemically. Acidic lens-protein degrading activity was widespread in ocular tissues. The ciliary body enzyme, which showed the highest activity at pH 3.8, was inhibited by pepstatin and leupeptin. Lens-protein degrading activity may result from a combination of cathepsins B, D, H and L.
D000818:Animals; D002417:Cattle; D002829:Choroid / Q000378:metabolism; D002924:Ciliary Body / Q000378:metabolism; D003315:Cornea / Q000378:metabolism; D003459:Crystallins / Q000378:metabolism*; D005123:Eye / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D007498:Iris / Q000378:metabolism; D007700:Kinetics; D007908:Lens, Crystalline / Q000378:metabolism; D010857:Pigment Epithelium of Eye / Q000378:metabolism; D012160:Retina / Q000378:metabolism
D003459:Crystallins