Functional properties of subsets of T lymphocytes defined by specific antigens.
Heteroantisera raised to the acute lymphocytic T (ALL) cell line HSB2 and to Sézary cells react with distinct subpopulations of T lymphocytes. Each antiserum reacts with a different T cell antigen and defines a distinct subpopulation that represents approximately 50% of peripheral blood T lymphocytes. The anti-HSB2-positive subpopulation contained suppressor cells for pokeweed mitogen-dependent immunoglobin (Ig) synthesis whereas the anti-Sézary cell serum-positive population included helper cells for Ig synthesis and mixed lymphocyte responder cells.
D000941:Antigens / Q000276:immunology; D002460:Cell Line; D003208:Concanavalin A / Q000494:pharmacology; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis; D007945:Leukemia, Lymphoid / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D012751:Sezary Syndrome / Q000276:immunology; D013601:T-Lymphocytes / Q000145:classification* / Q000276:immunology
D000941:Antigens; D007136:Immunoglobulins; D003208:Concanavalin A