Immunization with killed Acanthamoeba culbertsoni antigen and amoeba culture supernatant antigen in experimental Acanthamoeba meningoencephalitis.
Mice immunized with killed (sonicated) Acanthamoeba culbertsoni A-1 antigen displayed marked resistance to intranasal challenge with the amoeba. A primary immunization produced a survival rate of approximately 40%, and survival values of greater than 80% were obtained by multiple immunizations. Similarly mice immunized with fluids from A-1 cultures were highly resistant to infection.
D000562:Amebiasis / Q000401:mortality / Q000517:prevention & control*; D000656:Amoeba / Q000276:immunology; D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D005260:Female; D007114:Immunization; D008590:Meningoencephalitis / Q000401:mortality / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C
D000941:Antigens