[In vitro studies of fetal rat fibroblasts after experimental fenoterol administration].
White female rats were daily treated with Fenoterol in a dose of 1.8 mg/kg of body weight beginning with the 10th d till the end of gestation. Cell cultures were made by using the skin of mature foetuses. Fibroblast-like cells of primary and passaged cultures were examined. The slices were stained by Giemsa's reagent and examined with Brachet's reaction to ribonucleic acid. Histological reactions to acid phosphatase activity, succinic and lactic dehydrogenases demonstrated changes showing disturbed metabolism of the examined cells.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002478:Cells, Cultured; D004983:Ethanolamines / Q000494:pharmacology*; D005260:Female; D005280:Fenoterol / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects / Q000201:enzymology; D006651:Histocytochemistry; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects* / Q000196:embryology / Q000201:enzymology; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013997:Time Factors
D004983:Ethanolamines; D005280:Fenoterol; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D000135:Acid Phosphatase
In-vitro-Untersuchungen fetaler Rattenfibroblasten nach experimenteller Fenoterol-Anwendung.