Spinal leptomeningeal epidermoid cysts in inbred mouse strains.
The anatomic location and histological appearance of spinal cord epidermoid cysts in a variety of inbred mouse strains was examined. A variable incidence of cysts was found in mice of the C57BR/cdJ, C57BL/6J, B10.BR/SgSnJ, C58/J, AKR/J, C57L/J, and RF/J strains. Cysts were largely found in the leptomeninges, adjacent to the posterior horn and the lateral or anterior columns. The cysts consisted of a central whorled mass of keratinized cells surrounded by polygonal epithelial cells; some of these cells contained keratohyaline granules. Basal cells were absent. The presence of cysts did not correlate with the H-2k or H-2b haplotypes of the mouse.
D000818:Animals; D003520:Cyclophosphamide / Q000633:toxicity; D004814:Epidermal Cyst / Q000139:chemically induced / Q000473:pathology*; D007772:Lactate dehydrogenase-elevating virus / Q000472:pathogenicity; D008578:Meninges / Q000473:pathology*; D051379:Mice; D008815:Mice, Inbred Strains; D013116:Spinal Cord / Q000473:pathology; D013118:Spinal Cord Diseases / Q000139:chemically induced / Q000473:pathology*; D013126:Spinal Nerve Roots / Q000473:pathology; D014777:Virus Diseases / Q000473:pathology
D003520:Cyclophosphamide