Changes in acetylcholinesterase and cholinesterase activities in rat pancreas during postnatal development. Lack of relation with muscarinic receptor maturation.
This study was undertaken to establish if there is a correlation between the ontogenesis of cholinesterase activities and the cholinergic muscarinic receptors in the development of rat pancreas. Two different cholinesterase activities were detected in the pancreas: a true acetylcholinesterase and a pseudocholinesterase. The ratio of acetylcholinesterase to total cholinesterase activities varied as a function of age. Acetylcholinesterase and total cholinesterase specific activities (units per milligram protein) decreased sharply at weaning. When expressed on a DNA basis, both activities decreased constantly until age 30 days to increase slightly thereafter. However, a correlation could not be established between the development of acetylcholinesterase activity and the muscarinic receptors.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000375:Aging; D000818:Animals; D002091:Butyrylcholinesterase / Q000378:metabolism; D002802:Cholinesterases / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010179:Pancreas / Q000201:enzymology* / Q000254:growth & development; D011813:Quinuclidinyl Benzilate; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000378:metabolism / Q000502:physiology*
D011976:Receptors, Muscarinic; D011813:Quinuclidinyl Benzilate; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase; D002802:Cholinesterases