Dietary trans-fatty acid effects on mitochondrial functionality and phospholipid composition in rat perfused hearts in oxygenation and anoxia.
Dietary fatty acid fraction influence on heart composition is known and we have previously demonstrated a trans-fatty acid accumulation in heart. In this work we will verify trans-fatty acid effect on heart phospholipid fatty acid composition and miocardic mitochondrial respiratory activity under the influence of perfusion techniques in oxygenation and anoxic conditions. Results have pointed out, in group fed with 28% trans-fatty acid hydrogenated fat, a decreased mitochondrial functionality during perfusion in different oxygenation condition, probably correlated to different fatty acid composition of heart phospholipids.
D000818:Animals; D004041:Dietary Fats / Q000494:pharmacology*; D005227:Fatty Acids / Q000032:analysis / Q000494:pharmacology*; D000860:Hypoxia / Q000503:physiopathology*; D008929:Mitochondria, Heart / Q000502:physiology*; D010101:Oxygen Consumption / Q000187:drug effects; D010477:Perfusion; D010743:Phospholipids / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D004041:Dietary Fats; D005227:Fatty Acids; D010743:Phospholipids