SSEP chronotopography in patients with multiple sclerosis.
In 10 patients with definite MS, an SSEP chronotopogram was constructed of 7 different, well-defined components: N20, P25, P45, P100, N140, P200 and P300. Chronotopographical maps were constructed on the basis of the localization of maximal amplitudes of the different components and their dipolar counterparts (when present). Most patients showed a delay of different specific as well as aspecific components. The chronotopogram was not much different from normal except for P45. Most generators therefore seem to stay stable. One of the P45 dipole generators vanished, probably due to a slight change in its direction, or more probably as a consequence of loss of association fibres in the cortical white matter. Spatio-temporal mapping provides new, clinically relevant information. The development of automatic methods for this mapping is justified for routine clinical use in neurology.
D000328:Adult; D004594:Electrophysiology / Q000379:methods; D005073:Evoked Potentials, Somatosensory; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000503:physiopathology*; D011930:Reaction Time