Incidence of helminthic infections and comparative study of pyrantel pamoate with levamisole and mebendazole in hospital patients at Barisal, Bangladesh.
A study was carried out to find out the incidence of helminthic infections in hospitalized patients at Sher-e-Bangla Medical College, Barisal and to determine the comparative efficacy of pyrantel pamoate, levamisole, and mebendazole. It was observed that 76.2 per cent of total hospitalized patients were infected with intestinal helminths. Polyparasitism (52.6 per cent) was more frequent than single infection (21.8 per cent). Amongst these, 47.5 per cent was suffering from Asearis lumbricoides (AL), 42.5 per cent from Hookworm (H.W) and 65.8 per cent from trichuris trichura (TT). Out of 255 cases examined separately, 40 per cent was suffering from Enterobious vermicularis (EV) infection. The comparative study showed that mebendazole produced egg negative stool in 90.9 per cent of AL, 95.6 per cent of HW and 86.8 per cent of TT after eight days of treatment. On the other hand, pyrantel pamoate cured AL in 93.3 per cent, HW in 78.5 per cent and TT in 34.2 per cent eases. Levamisole cured 75 per cent AL, 4.1 per cent H.W. and 22.2 per cent TT within the same period.
D000293:Adolescent; D000328:Adult; D001196:Ascariasis / Q000188:drug therapy* / Q000453:epidemiology; D001459:Bangladesh; D001562:Benzimidazoles / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006725:Hookworm Infections / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D007978:Levamisole / Q000627:therapeutic use*; D008463:Mebendazole / Q000627:therapeutic use*; D011715:Pyrantel / Q000031:analogs & derivatives*; D011716:Pyrantel Pamoate / Q000627:therapeutic use*; D014257:Trichuriasis / Q000188:drug therapy* / Q000453:epidemiology
D001562:Benzimidazoles; D007978:Levamisole; D011715:Pyrantel; D011716:Pyrantel Pamoate; D008463:Mebendazole