Recombination between two mouse t haplotypes (tw12tf and tLub-1): mapping of the H-2 complex relative to centromere and tufted (tf) locus.
A monoclonal antibody known to recognize the H-2.m3 specificity is shown to react with the class I H-2 product of tLub-1 but not tw12tf mice. This reagent was used to study the segregation of the H-2 complex in the progeny of tLub-1 +/tw12tf females. The most straightforward interpretation of the results presented here is that these t haplotypes carry an H-2 complex located between the centromere and tufted locus. Possible consequences of such a location with regard to the recombination between t haplotypes and chromosome 17 from laboratory mice are discussed.
D000483:Alleles; D000818:Animals; D000911:Antibodies, Monoclonal; D002503:Centromere / Q000502:physiology*; D002874:Chromosome Mapping; D002875:Chromosomes / Q000502:physiology*; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000032:analysis / Q000235:genetics*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D000911:Antibodies, Monoclonal; D006183:H-2 Antigens