Persistence of patch test reactions to clioquinol (Vioform) and cross-sensitization.
Ten patients with positive patch test reactions to clioquinol were retested in 1979 after an average interval of 6 years. On subsequent testing we also examined test reactions to other quinoline derivatives (including antimalarial drugs) and potassium iodide. All patients showed a positive reaction to clioquinol at retesting. Many cross-reactions of hydroxyquinolines included reactions to quinoline-based antimalarial drugs, and a few allergic reactions to potassium iodide. The consequences of these findings are discussed.
D000328:Adult; D000368:Aged; D000962:Antimalarials / Q000009:adverse effects; D007464:Clioquinol / Q000009:adverse effects / Q000276:immunology*; D003429:Cross Reactions; D003876:Dermatitis, Atopic / Q000209:etiology* / Q000276:immunology; D004342:Drug Hypersensitivity / Q000209:etiology / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D011193:Potassium Iodide / Q000009:adverse effects; D011804:Quinolines / Q000009:adverse effects*
D000962:Antimalarials; D011804:Quinolines; D011193:Potassium Iodide; D007464:Clioquinol