Effect of linoleic acid hydroperoxide on uptake of low density lipoprotein by cultured smooth muscle cells from rabbit aorta.
The uptake of 125I-labelled low density lipoprotein by cultured smooth muscle cells from rabbit aorta was increased by linoleic acid hydroperoxide (3-6 nmol/ml); both the binding and the degradation of the low density lipoprotein were increased. These effects could be principally ascribed to the interaction of the hydroperoxide with the cells.
D000818:Animals; D001011:Aorta / Q000166:cytology; D001692:Biological Transport / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism; D002478:Cells, Cultured; D008041:Linoleic Acids / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*; D011817:Rabbits
D008041:Linoleic Acids; D008054:Lipid Peroxides; D008077:Lipoproteins, LDL; C008285:linoleic acid hydroperoxide