A possible explanation for the occurrence of increased beta-hexosaminidase activity in pregnancy serum.
The activities of the lysosomal enzymes beta-hexosaminidase, beta-glucuronidase, and beta-galactosidase were confirmed to be elevated in serum from pregnant women. The increased activity of beta-hexosaminidase and beta-glucuronidase showed the same changes in the isoenzyme pattern as found in serum from patients with some liver affections. In the light of recent findings, the increased activity of beta-hexosaminidase (and some other lysosomal enzymes) in pregnancy and liver disease might depend upon the non-parenchymal liver cells not being able properly to clear these enzymes from the blood.
D000135:Acid Phosphatase / Q000097:blood; D005260:Female; D005966:Glucuronidase / Q000097:blood; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D007525:Isoelectric Focusing; D007527:Isoenzymes / Q000097:blood*; D008247:Lysosomes / Q000201:enzymology; D011247:Pregnancy; D013997:Time Factors; D001616:beta-Galactosidase / Q000097:blood; D001619:beta-N-Acetylhexosaminidases
D007527:Isoenzymes; D000135:Acid Phosphatase; D006596:Hexosaminidases; D001616:beta-Galactosidase; D005966:Glucuronidase; D001619:beta-N-Acetylhexosaminidases