[Differences in the properties of specific T-suppressors and cytotoxic T-lymphocytes immune to H-2 complex antigens].
Intravenous immunization of mice with a large dose of gamma-irradiated allogenic spleen cells gives rise to specific suppressor T cells and cytotoxic lymphocytes (CTL). However, being optimal form suppressor T cell induction, these conditions of immunization are not conducive to identification of CTL unless they are enriched by elution from the allogenic target monolayer. Unlike CTL, specific suppressor T cells are highly susceptible to gamma-irradiation while their precursors differ from those of CTL by high susceptibility to cyclophosphamide and hydrocortisone.
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D003602:Cytotoxicity, Immunologic; D005720:Gamma Rays; D006183:H-2 Antigens / Q000276:immunology*; D006854:Hydrocortisone / Q000494:pharmacology; D007942:Leukemia, Experimental / Q000276:immunology; D051379:Mice; D013154:Spleen / Q000276:immunology / Q000528:radiation effects; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology* / Q000528:radiation effects
D006183:H-2 Antigens; D003520:Cyclophosphamide; D006854:Hydrocortisone
Razlichiia svoĭstv spetsificheskikh T-supressorov i tsitotoksicheskikh T-limfotsitov, immunykh k antigenam kompleksa H-2.