Lymphoblastogenesis stimulates proliferation of interacting Lyt1 T cells in a syngeneic system.
The intravenous transfer of polyclonally activated lymphoblasts elicited a proliferative response of host-derived Lyt1 T cells in the spleens of syngeneic recipient mice. These Lyt1 T cells (responding in vivo to a syngeneic lymphoblast graft) stimulated proliferation of resting, syngeneic splenic Lyt1 T cells, derived from uninjected mice, in a one-way syngeneic mixed lymphocyte culture in vitro. The data are discussed in the context of T cell activation induced by lymphoblastogenesis in a syngeneic system.
D000818:Animals; D002417:Cattle; D003165:Complement System Proteins; D005260:Female; D007518:Isoantibodies; D007519:Isoantigens; D008213:Lymphocyte Activation; D007959:Lymphocyte Culture Test, Mixed; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008937:Mitomycins / Q000494:pharmacology; D010641:Phenotype; D011817:Rabbits; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology
D007518:Isoantibodies; D007519:Isoantigens; D008937:Mitomycins; D003165:Complement System Proteins