[Genetic restriction on interaction between the effects of delayed hypersensitivity and suppressor cells].
Injection of a massive dose of sheep red blood cells (SRBC) to mice leads to activation of delayed type hypersensitivity (DTH) T suppressors in the spleen. T suppressors inhibit sensitization of syngeneic recipients with an optimal dose of SRBC. They also inhibit sensitization when transferred to syngeneic recipients and to semi-syngeneic strains. An obligatory condition for efficient suppression transfer was H-2 compatibility. Suppressor cells inhibited activation of DTH effector progenitors during the first day after the transfer. However, some of allogeneic cells persist in intact recipients for 4 days. Analysis of the data obtained shows that the absence of suppressions in H-2 incompatible mice is due to genetic restriction of cell interaction rather than to rejection of donors' cells.
D000818:Animals; D006183:H-2 Antigens / Q000032:analysis; D006824:Hybridization, Genetic; D006968:Hypersensitivity, Delayed / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000637:transplantation; D014184:Transplantation, Homologous
D006183:H-2 Antigens
Geneticheskaia restriktsiia vzaimodeĭstviia éffektov giperchuvstvitel'nosti zamedlennogo tipa s kletkami-supressorami.