Ceruletide analgesia in biliary colic.
Ceruletide is a decapeptide isolated from the skin of an Australian frog. Its chemical and biologic relationship to cholecystokinin and its potent relaxant effect on the sphincter of Oddi makes it useful in biliary colic. In this double-blind placebo-controlled experiment, 60 subjects with moderate to severe pain caused by biliary colic were injected with ceruletide, 1 ng/kg iv or with an equal volume of saline solution. Pain in the right hypochondrium, referred pain, and Murphy's sign were scored before and after treatment. Data indicate that ceruletide is effective in biliary colic.
D000328:Adult; D000368:Aged; D000700:Analgesics / Q000627:therapeutic use*; D001660:Biliary Tract Diseases / Q000188:drug therapy*; D002108:Ceruletide / Q000627:therapeutic use*; D003085:Colic / Q000188:drug therapy*; D004311:Double-Blind Method; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy*; D011897:Random Allocation
D000700:Analgesics; D002108:Ceruletide