[Free and sulfo-conjugated dehydroepiandrosterone in the brain of mice with myelin biosynthesis disorders].
Dehydroepiandrosterone, either unconjugated (D) or conjugated to sulfuric acid (DS), has been identified in the brain of male Mice; DS had been previously found in Rat brain. DS amounts in posterior brain, were 0.8-2.0 ng/g in controls, and very much lower in dysmyelinic jimpy and quaking Mice of the same age. Conversely, amounts of D were increased in affected Mice, suggesting an impaired sulfoconjugation. Results may be explained by accumulation of D and DS in brain, unrelated to the endocrine system.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003687:Dehydroepiandrosterone / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008816:Mice, Jimpy / Q000378:metabolism*; D008818:Mice, Neurologic Mutants / Q000378:metabolism*; D008821:Mice, Quaking / Q000378:metabolism*; D013431:Sulfates / Q000378:metabolism
D013431:Sulfates; D003687:Dehydroepiandrosterone
Déhydroépiandrostérone libre et sulfo-conjuguée dans le cerveau de souris dysmyéliniques.