[Effect of fenformin, L-DOPA and para-chlorophenylalanine on the immunological reactivity and chemical carcinogenesis in BALB/c mice].
Treatment with 20-methylcholanthrene resulted in the increase in hypothalamic levels of noradrenaline and serotonin in BALB/c mice. Immunization of carcinogen-treated animals with ovine erythrocytes was followed by changes in the hypothalamic levels of central neurotransmitters, opposite to those in intact immunized controls. After correction of the levels of neurotransmitters in the hypothalamus with phenformin, parachlorophenylalanine or L-dopa carried out prior to immunization, the fraction of antibody-producing cells in the spleen of carcinogen-treated mice returned to normal. A combined administration of immunostimulators and drugs for correction of hypothalamic levels of noradrenaline and serotonin potentiated inhibitory effect of the former on chemical carcinogenesis.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D010134:Fenclonine / Q000276:immunology* / Q000627:therapeutic use; D007031:Hypothalamus / Q000187:drug effects / Q000276:immunology; D007109:Immunity / Q000187:drug effects; D007114:Immunization; D007980:Levodopa / Q000276:immunology* / Q000627:therapeutic use; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000276:immunology*; D010629:Phenformin / Q000276:immunology* / Q000627:therapeutic use
D007980:Levodopa; D008748:Methylcholanthrene; D010629:Phenformin; D010134:Fenclonine
Vliianie fenformina, L-DOFA i parakhlorfenilalanina na immunologicheskuiu reaktivnost' i razvitiie khimicheskogo kantserogeneza u myshei BALB/c.