Effect of chronic exposure to carbon disulfide on biotransformation of phenazone in rabbits.
A significant but reversible inhibition of phenazone elimination was observed in rabbits chronically exposed to CS2. Lack of significant difference of phenazone pharmacokinetics in exposed rabbits 24 h after the last exposure compared with the control group, indicates that alteration of phenazone elimination after chronic exposure to CS2 is reversible. The results obtained with phenazone as a model substance suggest that, during chronic exposure to CS2, elimination of other drugs metabolized by the pathway similar to phenazone may also be altered. This should be taken into account in selecting their dosage.
D000818:Animals; D000983:Antipyrine / Q000378:metabolism*; D001711:Biotransformation / Q000187:drug effects; D002246:Carbon Disulfide / Q000633:toxicity*; D005260:Female; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D011817:Rabbits; D013997:Time Factors
D002246:Carbon Disulfide; D000983:Antipyrine