Effects of piperazine citrate and of the anti-Ascaris fraction of the ethanolic extract of the bark of Polyadoa umbellata (erin) on mammalian non-vascular smooth muscle.
At 500 micrograms-4 mg/ml piperazine and the anti-Ascaris fraction of the ethanolic extract of the bark of the erin tree (Polyadoa umbelleta) have equipotent inhibitory effects on submaximal contractions induced by equipotent doses of acetylcholine, nicotine and 5-hydroxytryptamine on the guinea-pig ileum and the rabbit duodenum. Similar inhibitory effects were noted on: acetylcholine, adrenaline, histamine, and barium chloride-induced contractions in the guinea-pig vas deferens, oxytocin and acetylcholine-induced contractions in the non-pregnant rat uterus. These actions indicate that piperazine and erin possess definite non-specific smooth muscle depressant properties. The need for the elucidation of the chemical nature of the active constituent in "erin" and for in-vivo anti-Ascaris activity studies in man is stressed.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D004386:Duodenum / Q000187:drug effects; D004558:Electric Stimulation; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects*; D009538:Nicotine / Q000494:pharmacology; D010121:Oxytocin / Q000494:pharmacology; D010879:Piperazines / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D014599:Uterus / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects
D000969:Antinematodal Agents; D010879:Piperazines; D010936:Plant Extracts; D012701:Serotonin; D010121:Oxytocin; C006589:piperazine citrate; D009538:Nicotine; D006632:Histamine; D000109:Acetylcholine