Metabolism of geraniol and linalool in the rat and effects on liver and lung microsomal enzymes.
Metabolites isolated from the urine of rats after oral administration of geraniol (I) were: geranic acid (II), 3-hydroxy-citronellic acid (III), 8-hydroxy-geraniol (IV), 8-carboxy-geraniol (V) and Hildebrandt acid (VI). Metabolites isolated from urine of rats after oral administration of linalool (VII) were 8-hydroxy-linalool (VIII) and 8-carboxy-linalool (IX). After three days of feeding rats with either geraniol or linalool, liver-microsomal cytochrome P-450 was increased. Both NADH- and NADPH-cytochrome c reductase activities were not significantly changed during the six days of treatment. Oral administration of these two terpenoids did not affect any of the lung-microsomal parameters measured.
D000080462:Acyclic Monoterpenes; D000284:Administration, Oral; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003573:Cytochrome b Group / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D039821:Monoterpenes; D009245:NADH Dehydrogenase / Q000378:metabolism; D051381:Rats; D013729:Terpenes / Q000378:metabolism* / Q000494:pharmacology / Q000652:urine
D000080462:Acyclic Monoterpenes; D003573:Cytochrome b Group; D039821:Monoterpenes; D013729:Terpenes; D003577:Cytochrome P-450 Enzyme System; C018584:linalool; D009245:NADH Dehydrogenase; C007836:geraniol