Two non-allelic human interferon alpha genes with identical coding regions.
A hitherto undescribed human interferon-alpha (IFN-alpha) gene, IFN-alpha 13, has been isolated and characterized. Its entire coding sequence is completely identical with that of IFN-alpha 1; the 5' and 3' non-coding regions differ by 4.5% and 3.8%, respectively. As the two genes are not allelic, we conclude that the similarity is due to a very recent gene conversion event. Both genes are expressed in virus-induced leukocytes.
D001483:Base Sequence; D003001:Cloning, Molecular; D004274:DNA, Recombinant / Q000032:analysis; D005785:Gene Conversion; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D007370:Interferon Type I / Q000235:genetics*; D007962:Leukocytes / Q000032:analysis; D012333:RNA, Messenger / Q000032:analysis; D014158:Transcription, Genetic
D004274:DNA, Recombinant; D007370:Interferon Type I; D012333:RNA, Messenger