Prevention of the teratogenic effect of 6-aminonicotinamide in chick embryos by nicotinic acid and L-methionine.
Administration of 6-aminonicotinamide into eggs may interfere with the development of the chick embryo. The prevention of this effect by nicotinamide has been shown before. In the present study, it could be demonstrated that a combination of nicotinic and L-methionine may also produce this effect. If applied alone nicotinic acid exhibited low effectiveness and L-methionine none at all.
D015120:6-Aminonicotinamide / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000818:Animals; D002642:Chick Embryo; D005121:Extremities / Q000196:embryology; D008715:Methionine / Q000494:pharmacology*; D009536:Niacinamide / Q000031:analogs & derivatives*; D009539:Nicotinic Acids / Q000494:pharmacology*; D013723:Teratogens / Q000037:antagonists & inhibitors*
D009539:Nicotinic Acids; D013723:Teratogens; D009536:Niacinamide; D015120:6-Aminonicotinamide; D008715:Methionine