Nitrogen analogues of phencyclidine: 1-alkyl-4-phenyl-4-(1-piperidinyl)piperidines.
In order to investigate the effect of the introduction of a nitrogen atom in the alicyclic moiety of phencyclidine (PCP) a series of 1-alkyl-4-phenyl-4-(1-piperidinyl)piperidines were synthesized. The in vivo assays in mice and EEG in rabbits indicated that the presence of a second basic center in the molecule resulted in a loss of PCP-like activity. The new compounds were devoid of analgesic activity.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D001921:Brain / Q000502:physiology; D055598:Chemical Phenomena; D002621:Chemistry; D004569:Electroencephalography; D004594:Electrophysiology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008968:Molecular Conformation; D009043:Motor Activity / Q000187:drug effects; D010622:Phencyclidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D011199:Potentiometry; D011817:Rabbits; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D010622:Phencyclidine