[Effect of anticonvulsants on convulsions induced by kynurenine, quinolinic acid, strychnine and corazole].
Benzobarbital, primidone, phenobarbital, phynytoin and trimethadionum (in order of decreasing activity) were moderately effective against DL-kynurenine (50 micrograms, i. c. v.)-induced seizures in SHR albino male mice. Diazepam was ineffective even in doses of 15 and 25 mg/kg. Against seizures induced by quinolinic acid (5 micrograms, i. c. v.) anticonvulsants, particularly primidone and phenytoin, were more effective than against kynurenine-induced seizures. Diazepam was slightly effective in high doses of 7-15 mg/kg. Primidone and benzobarbital in doses used (10-50 mg/kg) were ineffective against strychnine and pentylenetetrazol. Selective efficacy of primidone and benzobarbital in this model of seizures suggests that kynurenine and quinolinic acid could be involved in the grand mal fits in epileptic patients.
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D007737:Kynurenine / Q000037:antagonists & inhibitors; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D017378:Quinolinic Acid; D011805:Quinolinic Acids / Q000037:antagonists & inhibitors; D012640:Seizures / Q000139:chemically induced*
D000927:Anticonvulsants; D011805:Quinolinic Acids; D007737:Kynurenine; D017378:Quinolinic Acid; D010433:Pentylenetetrazole
Vliianie antikonvul'santov na sudorogi, vyzyvaemye kinureninom, khinolinovoĭ kislotoĭ, strikhninom i korazolom.