Influence of two prostaglandin synthesis inhibitors on the intratumor distribution of blood flow and vascular volume in a transplantable rat fibrosarcoma.
The intratumor and intramuscle distribution of blood flow and plasma volume was studied via isotope techniques in a transplantable rat fibrosarcoma. Administration of two prostaglandin synthesis inhibitors, indomethacin and diclofenac-sodium, had different effects. Indomethacin changed muscle plasma volume significantly towards higher values; a tendency to increased tumor plasma volume was also found. Diclofenac-sodium increased tumor blood flow, but had no significant influence on other parameters. These effects are discussed based on previous observations of reduction of tumor growth rate and tumor vascularization after administration of both drugs.
D000818:Animals; D004008:Diclofenac / Q000494:pharmacology*; D005354:Fibrosarcoma / Q000098:blood supply*; D007213:Indomethacin / Q000494:pharmacology*; D009132:Muscles / Q000098:blood supply; D009368:Neoplasm Transplantation; D010648:Phenylacetates / Q000494:pharmacology*; D010953:Plasma Volume / Q000187:drug effects*; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects
D010648:Phenylacetates; D011453:Prostaglandins; D004008:Diclofenac; D007213:Indomethacin