[Cellular mechanism of the antileukemic action of quinoline dibromide].
Autoradiography (3H-thymidine) and DNA-cytofluorometry were used to study the effect of quinoline dibromide (QD), a potential inhibitor of cobalamine-dependent methionine synthetase, on the kinetics of cell proliferation of L-1210 mouse leukemia. QD was found to produce the secondary blockade of leukemic cells in the late S-phase of the mitotic cycle. Such a mechanism of QD action promoted the potentiation of antitumor activity of the antimetabolites methotrexate, cytosine arabinoside and 5-fluorouracil during combined chemotherapy.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D005434:Flow Cytometry; D007399:Interphase / Q000187:drug effects; D007939:Leukemia L1210 / Q000188:drug therapy*; D051379:Mice; D008811:Mice, Inbred DBA; D008938:Mitosis / Q000187:drug effects; D009368:Neoplasm Transplantation; D011806:Quinolinium Compounds / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D011806:Quinolinium Compounds; C018435:quinolinium dibromide
Kletochnyĭ mekhanizm antileĭkemicheskogo deĭstviia dibromid-khinolina.