[Selective action of hydrazine sulfate in combination with thiophosphamide on tumor cell mitochondria].
Hydrazine sulfate significantly potentiated antitumor effect of thiophosphamide in experiments on rats with Walker's tumor. The treatment with hydrazine sulfate (60 mg/kg) plus thiophosphamide (1 mg/kg) resulted in suppression of tumor growth up to 90%, the dosage of thiophosphamide being therapeutically ineffective. Following hydrazine sulfate treatment, the activity (pH: 7.0-7.5-7.75) derived from tumors doubled, as compared with control. Similar results were obtained with enzymatic preparations. The activities of DNP-stimulated ATPase and solubilized enzymes in rat liver were not influenced by treatment.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D002279:Carcinoma 256, Walker / Q000188:drug therapy* / Q000201:enzymology; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D006834:Hydrazines / Q000627:therapeutic use*; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology; D009368:Neoplasm Transplantation; D051381:Rats; D013852:Thiotepa / Q000627:therapeutic use*
D006834:Hydrazines; C029424:hydrazine; D013852:Thiotepa; D000251:Adenosine Triphosphatases
Izbiratel'noe deĭstvie gidrazinsul'fata v sochetanii s tiofosfamidom na mitokhondrii opukholevykh kletok.