Effects of fominoben-HCl on rat liver.
The effect of Fominoben-HCl (Noleptan) was studied in male rats given 200 mg/kg/day over one, two or four weeks. In all three experiments a slight enlargement of the liver was observed. After one-week treatment, activity of microsomal mixed-function oxidase was stimulated without an increase in cytochrome P-450 content. After 2 or 4 weeks of treatment the activity of microsomal mixed-function oxidase expressed as the activity per microsomal protein remained unchanged. The fominoben-HCl-caused biochemical changes and the slight increase in organ weight of the liver were completely reversible within 2 weeks after cessation of treatment.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009025:Morpholines / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D009025:Morpholines; D002784:Cholesterol; D006899:Mixed Function Oxygenases