Role of adherent suppressor cells in the depression of cell-mediated immunity in Hodgkin's disease and lung carcinoma.
The mechanism of the depression of cell-mediated immunity (CMI) in patients with Hodgkin's disease (HD) and lung carcinoma (LC) was investigated before any treatment. In 9 patients out of 14 with HD and in 4 patients out of 14 with LD, a depressed lymphocyte reactivity to phytohaemagglutinin (PHA) was observed. In 3 out of 9 patients with HD and in 2 out of 4 patients with LC who exhibited a depressed lymphocyte response to PHA, suppression caused by adherent cells and mediated by prostaglandins was evidenced. No relationship was found between this mechanism of suppression and depression of CMI in vivo as judged by skin tests to common recall antigens.
D000293:Adolescent; D000328:Adult; D002448:Cell Adhesion; D002675:Child, Preschool; D005260:Female; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D008175:Lung Neoplasms / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D012882:Skin Tests; D050378:T-Lymphocytes, Regulatory / Q000276:immunology* / Q000502:physiology