[Suppressive effects of 5-bromuracile and 5-bromuracile-epsilon-aminocaproic acid on the humoral anti-sheep erythrocyte immune response of mice in vivo and in vitro (author's transl)].
4 x 30 mg/kg 5-bromuracile (5-BrU) - injected shortly after the antigen once per day - suppress the development of direct plaque forming cells (PFC) in the spleen of immunized mice on the 4th day of the primary reaction weakly. 5 higher doses epsilon-aminocapronic acid (ACA) were not immunosuppressive, but those of 5-BrU-ACA. The immunosuppression was of short time, 6 days later equal direct PFCs were found in the spleens of experimental and control groups. 5 x 150 mg/kg 5-BrU-ACA or ACA decreased the formation of indirect PFCs on the 10th day of immune response. In vivo 5-BrU and 5-BrU-ACA inhibited the development of non or specific stimulated spleen cells to direct PFCs only in partially cytotoxic concentrations of 5 times 10(-4) Mol.
D000614:Aminocaproates / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001976:Bromouracil / Q000494:pharmacology*; D002478:Cells, Cultured; D004912:Erythrocytes / Q000276:immunology*; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology
D000614:Aminocaproates; D001976:Bromouracil
Suppressive Wirkungen von 5-Bromuracil und 5-Bromuracil-Aminocapronsäure auf die humorale Anti-Schaferythrozyten-Immunreaktion der Maus in vivo und in vitro.