Effects of an anti-androgen in the laying hen (Gallus domesticus).
The daily injection of the anti-androgen, cyproterone acetate, into regularly laying hens failed to prevent ovulation immediately. The delayed response suggested that testosterone is not part of the ovarian positive feedback stimulus resulting from the presence of an ovulable follicle and leading to ovulation. Ovarian changes in treated birds, and their unimpaired response to LH-RH, suggested that the drug might be acting by altering ovarian steroid metabolism.
D000818:Animals; D002645:Chickens / Q000502:physiology*; D003129:Comb and Wattles / Q000187:drug effects; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017373:Cyproterone Acetate; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000097:blood; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects; D010057:Oviducts / Q000187:drug effects; D010058:Oviposition / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects*
D007987:Gonadotropin-Releasing Hormone; D017373:Cyproterone Acetate; D007986:Luteinizing Hormone; D003534:Cyproterone