Phosphorylation of cerebral cortex proteins during spreading cortical depression.
Spreading cortical depression induced by the topical application of 25 % KC1 onto on hemisphere of the rat brain produced an increase in 32P radioactivity in the proteins of the microsomal [+39 %] and membrane [+21 %] fraction of the affected hemicortex compared with the intact contralateral hemicortex; conversely, radioactivity in the cytosol fraction fell by 19 %, while in the mitochondrial fraction it remained the same. The results are evaluated from the aspects of a possible difference in the response of cAMP-dependent and cAMP-independent protein phosphorylation to the depolarization of cortical cells in vivo.
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002467:Cell Nucleus / Q000378:metabolism; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism*; D013181:Cortical Spreading Depression; D003600:Cytosol / Q000378:metabolism; D008297:Male; D008861:Microsomes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010758:Phosphorus / Q000378:metabolism*; D010766:Phosphorylation; D051381:Rats
D009419:Nerve Tissue Proteins; D010758:Phosphorus