Cefoperazone in Klebsiella meningitis: a case report.
A 51-year-old man with meningitis due to Klebsiella pneumoniae was treated with cefoperazone 6 to 8 g/day intravenously and was cured. Simultaneous blood and cerebrospinal fluid levels were measured. Trough levels of cefoperazone in cerebrospinal fluid were 9 and 12 mg/L. Cefoperazone should be considered for meningitis due to susceptible organisms resistant to customarily used antibacterial drugs.
D002438:Cefoperazone; D002511:Cephalosporins / Q000134:cerebrospinal fluid / Q000627:therapeutic use*; D006801:Humans; D007710:Klebsiella Infections / Q000188:drug therapy*; D007711:Klebsiella pneumoniae / Q000187:drug effects; D008297:Male; D008581:Meningitis / Q000188:drug therapy* / Q000382:microbiology; D008826:Microbial Sensitivity Tests; D008875:Middle Aged
D002511:Cephalosporins; D002438:Cefoperazone