Transplacental effects of 3,5-dimethyl-3'-isopropyl-L-thyronine on tubulin content in fetal brains in rats.
When 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) (10 ng/(g X day] was administered to pregnant rats, their infants showed signs of hyperthyroidism with suppressed body weight, tachycardia, and tremor at the day of birth. The brain weight did not change but the wet weight of the cerebral cortex was increased in the infants. Tubulin content (per wet weight and per whole tissue) was increased in the cerebral cortex and cerebellum but remained unchanged in the hypothalamus in the DIMIT-treated group. DIMIT-induced hyperthyroidism was shown to affect the development of the fetal brain.
D000818:Animals; D001921:Brain / Q000196:embryology / Q000378:metabolism*; D005260:Female; D006980:Hyperthyroidism / Q000139:chemically induced / Q000196:embryology; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D013970:Thyronines / Q000494:pharmacology*; D014018:Tissue Distribution; D014404:Tubulin / Q000378:metabolism*
D013970:Thyronines; D014404:Tubulin; C022861:3,5-dimethyl-3'-isopropyl-L-thyronine