[Effect of tri-iodine-containing x-ray contrast substances on the blood coagulation system in an experiment].
Experiments on white rats were made to examine the time course of hemocoagulation changes induced by intravenous injection of the triiodine-containing radiographic contrast agents, bilignost, verografin, triombrast, iodamide-380. The substances were found to exert a biphasic action: an initial decrease in the total coagulation is replaced by a tendency toward hypercoagulemia. In experiments in vitro, the radiographic contrast agents increased the time of plasma recalcification, the prothrombin time and retarded the thrombin-fibrinogen and thrombin-plasma reactions. Bilignost produced the most marked hypocoagulemia. It is suggested that the direct effects of the drugs on blood coagulation involve a decrease in the total blood coagulation activity.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D003287:Contrast Media / Q000494:pharmacology*; D003974:Diatrizoate Meglumine / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D007451:Iodamide / Q000494:pharmacology; D007462:Iodobenzenes / Q000494:pharmacology; D007463:Iodobenzoates / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013997:Time Factors; D014283:Triiodobenzoic Acids / Q000494:pharmacology*
D003287:Contrast Media; D007462:Iodobenzenes; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; C034344:iodoalphionic acid; D003974:Diatrizoate Meglumine; D007451:Iodamide
Vliianie nekotorykh triĭodsoderzhashchikh rentgenokontrastnykh veshchestv na sistemu svertyvaniia krovi v éksperimente.