[Effect of digoxin, strophanthin and isolanid on oxygen absorption, oxidative phosphorylation and the amount of cytochromes in the myocardial mitochondria and their ATPase activity].
A total of 200 nonlinear rats were used to study the release and utilization of energy in the normal myocardium on administration of clinical concentrations of cardiac glycosides. It was found that cardiac glycosides exert no effect on oxidative phosphorylation under utilization of alpha-ketoglutarate. At the same time digoxin and strophanthin ( to a less degree) intensify the phosphorylating activity of mitochondria, while isolanid has no effect on the oxidative and phosphorylating activity under oxidation of succinate. The content of the enzymes in the terminal portion of the respiratory chain, namely the myocardial mitochondria - cytochromes, did not change under the effect of cardiac glycosides. The test animals were shown to have an increased activity of actomyosin ATPase.
D000205:Actomyosin / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000378:metabolism*; D000818:Animals; D002301:Cardiac Glycosides / Q000494:pharmacology*; D003580:Cytochromes / Q000378:metabolism*; D004077:Digoxin / Q000494:pharmacology*; D007799:Lanatosides / Q000494:pharmacology*; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D013328:Strophanthins / Q000494:pharmacology*
D002301:Cardiac Glycosides; D003580:Cytochromes; D007799:Lanatosides; D013328:Strophanthins; C018548:lanatoside C; D004077:Digoxin; D000205:Actomyosin; D000251:Adenosine Triphosphatases
Vliianie digoksina, strofantina i izolanida na pogloshchenie kisloroda, okislitel'noe fosforilirovanie, kolichestvo tsitokhromov v mitokhondriiakh miokarda i ego ATF-aznuiu aktivnost'.