Stabilizing effects of coenzyme Q10 on potassium ion release, membrane potential and fluidity of rabbit red blood cells.
The effects of coenzyme Q10 (Co Q10) on potassium ion release, membrane potential and fluidity of rabbit red blood cells were studied. Co Q10 inhibited the increased potassium ion release induced by cetylamine or lysolecithin from the cells. Co Q10 slightly decreased the membrane potential monitored by changes in fluorescence intensity of cyanine dye, 3,3'-dipropyl-2,2'-thiodicarbocyanine iodide [diS-C3-(5)], and also slightly decreased the membrane fluidity measured by using 1,6-diphenyl-1,3,5-hexatriene (DPH). These effects of Co Q10 on the membrane are considered to be due to its membrane stabilizing activity by interaction with lipid bilayers of the membrane.
D000588:Amines / Q000037:antagonists & inhibitors; D000818:Animals; D003864:Depression, Chemical; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D006838:Hydrocarbons; D066298:In Vitro Techniques; D007477:Ions; D008244:Lysophosphatidylcholines / Q000037:antagonists & inhibitors; D008560:Membrane Fluidity / Q000187:drug effects*; D008563:Membrane Lipids / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D011188:Potassium / Q000097:blood*; D011817:Rabbits; D014451:Ubiquinone / Q000494:pharmacology*
D000588:Amines; D006838:Hydrocarbons; D007477:Ions; D008244:Lysophosphatidylcholines; D008563:Membrane Lipids; D014451:Ubiquinone; C013553:hexadecylamine; D011188:Potassium