Further experiments on the pharmacological actions of ergometrine.
Ergometrine is able to increase the acid output from stomach-perfused rat preparation and its effect is antagonized by cimetidine. The drug excite the H1 receptors of guinea-pig's long strip. On the coronary artery isolated strip the alkaloid causes a potent vasoconstrictor effect mediator through receptors for biogenic amines.
D000818:Animals; D002417:Cattle; D002927:Cimetidine / Q000494:pharmacology; D003331:Coronary Vessels / Q000187:drug effects* / Q000502:physiology; D017259:Dimaprit; D004874:Ergonovine / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D011738:Pyrilamine / Q000494:pharmacology; D051381:Rats; D011969:Receptors, Histamine H1 / Q000187:drug effects; D011970:Receptors, Histamine H2 / Q000187:drug effects; D013890:Thiourea / Q000494:pharmacology
D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D002927:Cimetidine; D006632:Histamine; D013890:Thiourea; D011738:Pyrilamine; D004874:Ergonovine; D017259:Dimaprit