Mast cell stabilizing compound FPL 55618 reduces right ventricular hypertrophy and lung mast cell hyperplasia in chronically hypoxic rats.
Rats treated with chronic hypobaric hypoxia (21 days, 380 Torr) and mast cell stabilizing compound FPL 55618 had significantly less right ventricular hypertrophy and lung mast cell hyperplasia than rats subjected to chronic hypoxia alone. Right ventricular blood pressure was not reduced.
D000818:Animals; D006332:Cardiomegaly / Q000188:drug therapy* / Q000209:etiology; D002867:Chromones / Q000627:therapeutic use*; D005260:Female; D006965:Hyperplasia / Q000188:drug therapy / Q000209:etiology; D000860:Hypoxia / Q000150:complications*; D008168:Lung / Q000473:pathology*; D008407:Mast Cells / Q000187:drug effects*; D051381:Rats
D002867:Chromones; C021947:FPL 55618