Postnatal variations of endo-beta-D-N-acetyl-glucosaminidase in the developing rat cerebellum.
Some properties and the level of endo-beta-N-acetylglucosaminidase were studied during the postnatal development of the rat cerebellum. No isoenzymes were detected. The enzyme (essentially cytosolic) showed a peak of total and specific activity at the 24th postnatal day. The hypothesis was formulated that glycoprotein glycans could be degraded in two steps: one lysosomal, the other cytosolic.
D000367:Age Factors; D000818:Animals; D002531:Cerebellum / Q000201:enzymology* / Q000254:growth & development; D003600:Cytosol / Q000378:metabolism; D006596:Hexosaminidases / Q000378:metabolism*; D007527:Isoenzymes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D008970:Molecular Weight; D011134:Polysaccharides / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D007527:Isoenzymes; D011134:Polysaccharides; D006596:Hexosaminidases; C028551:endo-beta-glucosaminidase