Irradiation crosslinking of the polytetrapeptide of elastin and compounding to dacron to produce a potential prosthetic material with elasticity and strength.
The poly(tetra peptide), H-(L . Val1-L . Pro2-Gly3-Gly4)n-L . Val-OMe, which is a recurring sequence in tropoelastin the precursor protein of the elastic fiber, has been irradiation crosslinked to produce an elastomeric material with limited strength. When a material such as a Dacron fabric is impregnated by the coacervate phase of the poly(tetrapeptide) prior to irradiation crosslinking at 50 Mrad, the crosslinked product exhibits stress-strain curves with good elastomeric properties and high strength. In addition to the stress-strain curves, the material is characterized by scanning electron microscopy.
D001672:Biocompatible Materials / Q000138:chemical synthesis*; D001705:Bioprosthesis; D055598:Chemical Phenomena; D002621:Chemistry; D004548:Elasticity; D004549:Elastin; D011093:Polyethylene Terephthalates; D013718:Tensile Strength
D001672:Biocompatible Materials; D011093:Polyethylene Terephthalates; D004549:Elastin