Evaluation of cefmetazole and piperacillin with or without tobramycin for infections in patients with hematological disorders.
The combination of cefmetazole and piperacillin was compared with the combination of cefmetazole, piperacillin and tobramycin in the treatment of 20 patients with hematological disorders. The response rate was similar for both treatments (90% vs. 80%), and the difference was not statistically significant. The rate of serum glutamic pyruvic transaminase elevation was higher in patients treated with cefmetazole, piperacillin and tobramycin than in those treated with cefmetazole and piperacillin. Cefmetazole and piperacillin without tobramycin appear to be an effective combination with acceptable toxicity for empirical therapy of febrile episodes occurring in patients with hematological disorders.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000150:complications; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy*; D015311:Cefmetazole; D002511:Cephalosporins / Q000627:therapeutic use*; D002513:Cephamycins / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006402:Hematologic Diseases / Q000150:complications*; D006801:Humans; D007938:Leukemia / Q000150:complications; D007958:Leukocyte Count; D008223:Lymphoma / Q000150:complications; D008297:Male; D008875:Middle Aged; D009504:Neutrophils; D010406:Penicillins / Q000627:therapeutic use*; D010878:Piperacillin; D014031:Tobramycin / Q000627:therapeutic use*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002513:Cephamycins; D010406:Penicillins; D015311:Cefmetazole; D014031:Tobramycin; D010878:Piperacillin