Comparative trial of oltipraz versus praziquantel in the treatment of urinary schistosomiasis in the Gabon.
The efficacy of oltipraz as a schistosomicidal drug was investigated in Gabonese children suffering from urinary schistosomiasis in the dosages of 1 X 25 mg/kg body weight, 1 X 35 mg/kg body weight, and 2 X 20 mg/kg body weight and compared to praziquantel, 2 X 30 mg/kg body weight. The study was undertaken in 165 patients, and follow-up investigations were carried out 6 weeks and 12 weeks after treatment. Oltipraz showed less efficacy compared to praziquantel when dosages of 1 X 25 and 1 X 35 mg/kg body weight were given. However, oltipraz 2 X 20 mg/kg body weight was equivalent to praziquantel 2 X 30 mg/kg body weight. Parasitological cure was obtained in 79% of patients treated by oltipraz and 81% of patients treated by praziquantel. Side effects were insignificant in both treatment groups. Thus, the same parasitological cure could be achieved by oltipraz as well as by praziquantel, but with a lower dosage of oltipraz.
D000293:Adolescent; D002648:Child; D005260:Female; D005681:Gabon; D006801:Humans; D007546:Isoquinolines / Q000627:therapeutic use*; D008297:Male; D010270:Parasite Egg Count; D011223:Praziquantel / Q000008:administration & dosage / Q000627:therapeutic use*; D011719:Pyrazines / Q000008:administration & dosage / Q000627:therapeutic use*; D012547:Schistosoma; D012548:Schistosoma haematobium; D012552:Schistosomiasis / Q000188:drug therapy*; D012556:Schistosomicides / Q000008:administration & dosage / Q000627:therapeutic use*; D013045:Species Specificity; D013871:Thiones; D013876:Thiophenes; D014556:Urine / Q000469:parasitology; D014570:Urologic Diseases / Q000188:drug therapy*
D007546:Isoquinolines; D011719:Pyrazines; D012556:Schistosomicides; D013871:Thiones; D013876:Thiophenes; D011223:Praziquantel; C026209:oltipraz