[Continuous oral phenobarbital or intermittent rectal diazepam for the prevention of febrile convulsions].
During 18 months 100 children were submitted to a longitudinal study, in order to compare the efficacy of treatment with administration of intermittent rectal diazepam versus oral BID phenobarbital therapy, for prevention of febrile seizures. The group was divide in a randomized trial. Rectal diazepam was administered at dose os 0.5 mg/kg dose and the dose was repeated every eight hours during the period of fever. Diazepam was found to be as effective as oral phenobarbital in the prevention of new febrile seizures.
D000284:Administration, Oral; D002675:Child, Preschool; D003975:Diazepam / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007223:Infant; D008137:Longitudinal Studies; D008297:Male; D010634:Phenobarbital / Q000008:administration & dosage / Q000627:therapeutic use*; D011897:Random Allocation; D012007:Rectum; D012008:Recurrence; D003294:Seizures, Febrile / Q000517:prevention & control*
D003975:Diazepam; D010634:Phenobarbital
Fenobarbital oral continuado o diazepam rectal intermitente para la prevención de las crisis febriles.