[Action of adrenergic substances on the healing of experimental neurogenic mucosal damages and on the noradrenaline level in the stomach wall].
A study was made of the effect of the MAO inhibitor iprazide (50 mg/kg), alpha-methyldopa (150 mg/kg), and the beta-adrenoblocker inderal (15 mg/kg) on the rate of the healing of gastric mucosa erosions and noradrenaline content in the gastric wall of rats exposed to 3 hours of electric stimulation and immobilization. Iprazide accelerated the reparation of the gastric mucosa, alpha-methyldopa retarded it, whereas inderal did not influence that process. The drugs did not affect the rate of the recovery of noradrenaline content.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D007490:Iproniazid / Q000627:therapeutic use; D008297:Male; D008750:Methyldopa / Q000627:therapeutic use; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use; D009638:Norepinephrine / Q000378:metabolism*; D011433:Propranolol / Q000627:therapeutic use; D051381:Rats; D012149:Restraint, Physical; D013270:Stomach / Q000187:drug effects; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D013566:Sympathomimetics / Q000627:therapeutic use*; D014945:Wound Healing / Q000187:drug effects*
D008996:Monoamine Oxidase Inhibitors; D013566:Sympathomimetics; D008750:Methyldopa; D011433:Propranolol; D007490:Iproniazid; D009638:Norepinephrine
Deĭstvie nekotorykh adrenergicheskikh veshchestv na zazhivlenie éksperimental'nykh neĭrogennykh povrezhdeniĭ slizistoĭ i uroven' noradrenalina v stenke zheludka.