A 14q+ chromosome in adult T-cell leukemia.
Chromosome studies were conducted on two patients with adult T-cell leukemia. In both patients, a marker chromosome 14q+ and a structural change involving chromosome 1 with trisomy of the q arm were found in peripheral blood leukocytes. The 14q+ marker chromosome had resulted from translocation from #5p in one patient and #5q in the other patient. The present and previous studies suggest that the donor chromosomes involved in the 14q+ translocation are variable. This indicates that the 14q+ marker chromosome rather than the donor chromosome is intimately related with adult T-cell leukemia.
D000328:Adult; D002900:Chromosomes, Human, 1-3; D002901:Chromosomes, Human, 13-15; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000097:blood*; D007962:Leukocytes / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes; D014314:Trisomy