[Participation of the brain serotoninergic system in creating the stress reactivity of the hypophyseal-adrenal axis].
The concentration of corticosteroids in the blood of rats was shown to increase in response to the immobilization stress at an earlier age than the brain serotonin metabolism changes. The level of corticosteroids in blood increased in response to the intraperitoneal serotonin injection also earlier than the reaction to the serotonin injection in the brain lateral ventricle sets up. The increase of the reaction of hypophysial-suprarenal system to stress during the period from the 12th till the 16th day of postnatal development coincided with the changes in serotonin metabolism in the brain stem and the reaction to serotonin injection in the brain lateral ventricle. It is suggested that the system of serotonin brain neurons connected with the hypophysial-suprarenal complex matures later tran the serotonin receptors in the periphery; the reaction to immobilization may be realized at the early developmental stages without the participation of brain serotonin.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000187:drug effects / Q000254:growth & development* / Q000503:physiopathology; D010134:Fenclonine / Q000494:pharmacology; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000254:growth & development* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects; D012149:Restraint, Physical; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology*; D013312:Stress, Physiological / Q000209:etiology* / Q000503:physiopathology
D011985:Receptors, Serotonin; D012701:Serotonin; D010134:Fenclonine
Uchastie serotoninergicheskoĭ sistemy mozga v formirovanii stressornoĭ reaktivnosti gipofizarno-nadpochechnikovogo kompleksa.