Nonspecific human lymphocyte-mediated cytotoxicity induced by immobilized IgG aggregate: regulation by suppressor cells.
Normal human lymphocytes lyse a variety of erythrocytes when effector cells and target cells are incubated on immobilized, normal human IgG aggregates (10). Lymphocyte-mediated cytolysis induced by immobilized aggregate requires an overnight incubation with adherent mononuclear cells. This study was carried out to determine whether preincubation with adherent cells effects the activation of a cytolytic cell or inactivation of a suppressor cell. It was determined that a suppressor cell function is inactivated, and the suppressor cells were characterized as T gamma and T mu lymphocytes.
D000920:Antibody-Dependent Cell Cytotoxicity; D003602:Cytotoxicity, Immunologic; D006461:Hemolysis; D006801:Humans; D007113:Immunity, Innate; D007074:Immunoglobulin G; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000276:immunology*; D009000:Monocytes / Q000276:immunology; D011961:Receptors, Fc; D013601:T-Lymphocytes / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D007074:Immunoglobulin G; D011961:Receptors, Fc