On the influence of hydrocortisone on the stimulation of mouse spleen cells by PHA. Evidence for the involvement of suppressor cells.
The stimulation rate with PHA of murine spleen cells increases after removal of glass-adherent cells from the total spleen population. Unfractionated spleen population from HC treated mice suppresses the response to PHA of glass non-adherent cells from untreated animals only 24-48 h after HC treatment. From the third day on after the treatment the suppressive effect disappears.
D000818:Animals; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology*; D051379:Mice; D010835:Phytohemagglutinins / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology* / Q000187:drug effects; D050378:T-Lymphocytes, Regulatory / Q000502:physiology*
D010835:Phytohemagglutinins; D006854:Hydrocortisone