Halo nevi and melanoma.
Halo nevi may be associated with occult melanoma or may signify melanoma in a remote location. When a single halo nevus is present, the lesion should be biopsied to exclude melanoma. In addition, the patient's entire skin surface should be examined, and a careful ophthalmologic examination should be performed to exclude intraocular melanoma. Although the pathophysiologic relationship of halo nevus to melanoma is unclear, immunologic mechanisms have been postulated.
D000328:Adult; D003937:Diagnosis, Differential; D005134:Eye Neoplasms / Q000175:diagnosis; D005260:Female; D006801:Humans; D008545:Melanoma / Q000175:diagnosis*; D009508:Nevus, Pigmented / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D012878:Skin Neoplasms / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology