Induction of sister-chromatid exchanges in vivo in mice by the mycotoxins sterigmatocystin and griseofulvin.
Two naturally occurring fungal mycotoxins, sterigmatocystin and griseofulvin, were tested for induction of sister-chromatid exchanges (SCEs) in bone marrow cells of female Swiss albino mice. Sterigmatocystin gave elevated SCE frequencies at all doses tested (0.06-6.0 mg/kg). In contrast, griseofulvin, tested from 0.4 to 200 mg/kg, elevated the SCE frequency only in those mice which received doses of 100 or 200 mg/kg body weight. These results indicate that both fungal mycotoxins induce SCE in vivo and are potentially mutagenic.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D003434:Crossing Over, Genetic / Q000187:drug effects*; D005260:Female; D006118:Griseofulvin / Q000633:toxicity*; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013241:Sterigmatocystin / Q000633:toxicity*; D014966:Xanthenes / Q000633:toxicity*
D009153:Mutagens; D014966:Xanthenes; D013241:Sterigmatocystin; D006118:Griseofulvin