Tachycardia prevention by programmed stimulation.
Ten patients with an atrioventricular accessory pathway were studied by standard electrophysiologic techniques to determine if reentrant tachycardia can be prevented in these patients by delivery of a single extrastimulus, applied at a critical time after the tachycardia-initiating stimulus (or stimuli). In all 10 patients, reentrant tachycardia was reproducibly induced from the high right atrium with a single premature beat, and initiation of tachycardia could be prevented from the same site by a second premature beat. This second extrastimulus was effective if delivered within a zone that began 10 ms outside of the effective refractory period of the tachycardia-initiating stimulus and averaged 50 ms in width. This zone was termed the "preventive zone." The width of the preventive zone was independent of the initial tachycardia interval and the tachycardia cycle length. Prevention of reentrant tachycardia was always possible with a single atrial extrastimulus, whereas termination of the ongoing tachycardia required at least 2 atrial extrastimuli or stimulation from the right ventricle.
D000293:Adolescent; D000328:Adult; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D013610:Tachycardia / Q000503:physiopathology / Q000517:prevention & control*