Adoptive transfer of immunity to Histoplasma capsulatum in athymic nude mice.
Studies of adoptive transfer of resistance to Histoplasma capsulatum were performed with athymic nude (nu/nu) recipients and heterozygous (nu/+) donor mice. This model has the benefit of employing a recipient mouse (nu/nu) which cannot be immunized actively against H. capsulatum. Nu/nu mice were protected against H. capsulatum by whole spleen cells, fractioned T lymphocytes, and macrophages from immunized nu/+ donor mice. Similar cell populations from nonimmune nu/+ mice were not protective. Treatment with gold sodium thiomalate, an inhibitor of macrophage function, increased susceptibility to H. capsulatum in nu/+ and nu/nu mice. Adoptive transfer of immunity to H. capsulatum is multifactorial and depends on both T lymphocytes and macrophages.
D000818:Animals; D005856:Germ-Free Life; D006660:Histoplasmosis / Q000276:immunology*; D007112:Immunity, Maternally-Acquired / Q000187:drug effects; D007116:Immunization, Passive; D008264:Macrophages / Q000637:transplantation; D051379:Mice; D008819:Mice, Nude; D013047:Specific Pathogen-Free Organisms; D013154:Spleen / Q000637:transplantation; D013601:T-Lymphocytes / Q000637:transplantation; D013870:Thiomalates / Q000494:pharmacology; D014184:Transplantation, Homologous
D013870:Thiomalates