Adjuvant therapy of Dukes' C colon cancer by intra-arterial P-32 colloid for internal radiation therapy of the liver.
To prevent probable occult metastatic liver cancer from progressing to clinical disease, the author used internal radiation therapy as an effective adjuvant to surgical excision of primary Dukes' C colonic cancer. A calculated radiation dose of 5000 rads was delivered to the liver by injecting radioactive 32-P chromic phosphate colloid through the superior mesenteric and celiac arteries. When this was done, the colloid passed through the intestines and was mixed thoroughly with the blood and delivered to the liver by the portal vein. The Kupffer cells in the liver trapped the colloid, and a minimum amount passed through the liver and got into the general circulation. This kept the amount of colloid deposited in the bone marrow to a minimum. In a phase-I pilot study in which nine patients were treated, no serious side effects were noted. In eight patients, the liver has remained free of cancer for more than 1 year.
D000328:Adult; D000368:Aged; D000818:Animals; D002857:Chromium / Q000627:therapeutic use*; D017608:Chromium Compounds; D003102:Colloids; D003110:Colonic Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006801:Humans; D007269:Injections, Intra-Arterial; D008113:Liver Neoplasms / Q000532:radiotherapy* / Q000556:secondary / Q000601:surgery; D008875:Middle Aged; D010710:Phosphates / Q000627:therapeutic use*; D011829:Radiation Dosage; D011868:Radioisotopes / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D017608:Chromium Compounds; D003102:Colloids; D010710:Phosphates; D011868:Radioisotopes; D002857:Chromium; C509369:chromic phosphate