The association between long-term diabetic control and early retinopathy.
A study was performed to determine the relationship between level of long-term antecedent diabetic control and early diabetic retinopathy changes. Fifty-eight insulin dependent diabetics aged 14 to 17 1/2 years, with duration of diabetes of at least 8 years, were studied. Glycosylated hemoglobins were assessed a mean of 8.5 times per patient, over a mean period of 3.1 years, representing 28% of the mean duration of diabetes in this patient population. Fluorescein angiography, obtained according to a standardized technique, was assessed in masked fashion for number of microaneurysms, presence of abnormal areas of capillary nonperfusion, and presence of intraretinal dye leakage. Sixty-four percent of the study population showed some evidence of retinopathy. There was a high correlation found between degree of metabolic control as measured by glycosylated hemoglobin level, and presence of early retinopathy changes as defined by angiography.
D000293:Adolescent; D000783:Aneurysm / Q000175:diagnosis; D002196:Capillaries; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000150:complications* / Q000517:prevention & control; D003925:Diabetic Angiopathies / Q000175:diagnosis; D003930:Diabetic Retinopathy / Q000175:diagnosis / Q000453:epidemiology*; D005260:Female; D005451:Fluorescein Angiography; D006442:Glycated Hemoglobin / Q000032:analysis*; D006801:Humans; D008266:Macula Lutea; D008297:Male; D012171:Retinal Vessels; D013997:Time Factors
D006442:Glycated Hemoglobin