[Mezlocillin and beta-lactamases (author's transl)].
Like all penicillins, mezlocillin is degraded by beta-lactamases of the penicillinase type. It is also degraded to some extent by beta-lactamases of the cephalosporinase type. Yet in both cases mezlocillin behaves approximately like the first and second generation cephalosporins. This, together with good intrinsic activity, accounts for the valuable antibacterial properties of the antibiotic, particularly against Enterobacteriacaea.
D002510:Cephalosporinase / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology; D007700:Kinetics; D008802:Mezlocillin; D010405:Penicillinase / Q000378:metabolism; D010406:Penicillins / Q000378:metabolism* / Q000494:pharmacology; D001618:beta-Lactamases / Q000378:metabolism*
D010406:Penicillins; D002510:Cephalosporinase; D010405:Penicillinase; D001618:beta-Lactamases; D008802:Mezlocillin
Mezlocilline : action des bêta-lactamases.