[The effect of thyroid hormone administration and its exclusion on the development of cardiac hypertrophy in rabbits].
The authors, using rabbits for their experiments (26), studied the effect of application of thyroid hormones (Thyreoiodine Spofa) and that exclusion of these hormones by means of thyroidectomy on the mass of the heart, the concentration of nucleic acids and proteins in the subcellular structures of the heart muscle of intact animals. They observed that administration of hormones of the thyroid gland in a relatively short time led to hyperthrophy of the heart, increased concentration of ribonucleic acid and to modifications of the concentration of proteins in the subcellular structures of the heart muscle. Exclusion of the thyroid hormones, on the other hand, caused a decrease of the mass of the myocardium, decrease concentrations of RNA, DNA and also that of the proteins of the mitochondrial and myofibrillar fractions of the myocardium. The authors express the opinion that the thyroid hormones may participate in the evolution of hypertrophy of the heart muscle directly by stimulating synthesis of nucleic acids and proteins. Indirectly they may influence the process of hypertrophy through their heamodynamic actions by means of which they change the load of the heart.
D000818:Animals; D006332:Cardiomegaly / Q000503:physiopathology*; D008297:Male; D011817:Rabbits; D013963:Thyroid Hormones / Q000494:pharmacology / Q000502:physiology*; D013965:Thyroidectomy
D013963:Thyroid Hormones
Vplyv podávania a vyradenia tyreoidálnych hormónov na rozvoj hypertrofie srdca králikov.