[Histidine-rich protein synthesis in the mouse epidermis in the early periods after stimulation of epidermocyte proliferation and the effect of chalones].
Using autoradiographic and biochemical methods, the induction of epidermocyte proliferation in adult rats by plucking was shown to stimulate histidine-rich protein synthesis molecular markers of epidermocyte differentiation 6-8 hours before DNA synthesis. Epidermal chalones stimulate 3H-leucine incorporation into urine-dissolving proteins of the epidermis and diminish histidine-rich protein synthesis. These data suggest that chalones not only inhibit the epidermocyte proliferative activity, but also influence the processes of its differentiation.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D000078404:Epidermal Cells; D004817:Epidermis / Q000378:metabolism*; D006131:Growth Inhibitors / Q000494:pharmacology*; D006204:Hair Removal; D006639:Histidine / Q000096:biosynthesis*; D051379:Mice; D008810:Mice, Inbred C57BL; D014176:Protein Biosynthesis; D013997:Time Factors
D006131:Growth Inhibitors; D006639:Histidine
Izuchenie sinteza gistidin-bogatykh belkov v épidermise mysheĭ v rannie sroki posle stimuliatsii proliferatsii épidermotsitov i vliianie na nego keĭlonov.