Expression of endogenous retroviral glycoprotein 70 by antigen-activated cytotoxic and suppressor T lymphocytes of nice.
Concanavalin A-stimulated murine spleen cells and antigen-stimulated B lymphocytes of normal mice express an antigen that reacts with goat antiserum against glycoprotein (gp) 70. Structural analysis of this antigen characterizes it as endogenous viral gp70 that is most likely of xenotropic origin. Activated nonspecific T suppressor cells and cytotoxic T lymphocytes express endogenous viral gp70, whereas nonactivated mouse T or B lymphocytes do not. The presence of endogenous retroviral gp70 is thus a novel marker for activated mouse lymphocytes in general.
D000818:Animals; D001402:B-Lymphocytes / Q000032:analysis; D003602:Cytotoxicity, Immunologic; D006023:Glycoproteins / Q000032:analysis; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D012190:Retroviridae / Q000032:analysis*; D013601:T-Lymphocytes / Q000032:analysis* / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000032:analysis*; D014759:Viral Envelope Proteins; D014764:Viral Proteins / Q000032:analysis*
D006023:Glycoproteins; D014759:Viral Envelope Proteins; D014764:Viral Proteins