1-Acyltriazoles as antiinflammatory agents.
Certain 1-acyl-3-phenyl-5-alkyltriazoles were synthesized and evaluated for antiinflammatory activity using the mouse active Arthus (MAA) reaction as the test system. Modification of the acyl group, 4-phenyl substituent, and alkyl group led to the selection of the most active member of this series, 1-acetyl-3-(4-chlorophenyl)-5-methyl-1,2,4-triazole (3c), for further evaluation as a novel nonacidic antiinflammatory agent.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000633:toxicity; D001169:Arthritis, Experimental / Q000188:drug therapy; D001183:Arthus Reaction / Q000188:drug therapy; D004487:Edema / Q000188:drug therapy; D007052:Ibuprofen / Q000494:pharmacology; D008297:Male; D051379:Mice; D013329:Structure-Activity Relationship; D014230:Triazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D014230:Triazoles; D007052:Ibuprofen