Interaction of parachlorophenylalanine, mianserine and danitracen with amphetamine.
Three antiserotonin compounds, p-chlorphenylalanine, mianserine and danitracen, were investigated for their influence on amphetamine stereotypy in correlation with concentration of this amine in blood serum and brain tissue. A positive correlation (decrease of stereotypy as well as the concentration of amphetamine in serum and brain) was found only for danitracen. p-Chlorphenylalanine and mianserine premedication decreased serum and brain tissue concentration of amphetamine, but enhanced amphetamine stereotypy effect. It is assumed that in the mixed pharmacodynamic-pharmacokinetic interaction in the case of mianserine and p-chlorphenylalanine the pharmacodynamic component (inhibition of the serotoninergic system in CNS) prevails, whereas in the case of danitracen the pharmacokinetic effect was superior.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D010134:Fenclonine / Q000494:pharmacology; D006801:Humans; D008297:Male; D008803:Mianserin / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects*
D010880:Piperidines; D012702:Serotonin Antagonists; D008803:Mianserin; D000661:Amphetamine; D010134:Fenclonine