Platelet glyoxalases in thrombocytosis.
In platelets of patients suffering from thrombocytosis due to myeloproliferative disorders, glyoxalase I activity is significantly higher than in controls (P less than 0.01), while glyoxalase II levels are the same (P less than 0.3). The cellular concentration of glutathione is also increased in patients. Km values for methylglyoxal (glyoxalase I) and S-lactoylglutathione (glyoxalase II) are identical both in normal and pathological subjects, as are the thermostability of the two enzymes. The higher activity observed for glyoxalase I in patients could be related to a specific role of this enzyme in platelets.
D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000201:enzymology*; D005260:Female; D006801:Humans; D007791:Lactoylglutathione Lyase / Q000097:blood*; D008190:Lyases / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000150:complications; D013869:Thiolester Hydrolases / Q000097:blood*; D013922:Thrombocytosis / Q000201:enzymology* / Q000209:etiology; D000099301:Hydroxyacylglutathione Hydrolase
D007791:Lactoylglutathione Lyase; D008190:Lyases; D013869:Thiolester Hydrolases; D000099301:Hydroxyacylglutathione Hydrolase