Effect of adrenergic blockers on the dog's sleep-wake pattern.
Different results are reported for the effects of an alpha and beta adrenergic blocker on the 24-hr sleep-wake patterns in dogs. While propranolol did not affect the 24-hr sleep-wake parameters, phentolamine significantly reduced delta sleep (stage 2), shortened the length of the sleep episodes, and decreased the number of REM episodes in each sleep-wake cycle. Phentolamine effects are explained by increased arousals within sleep episodes.
D000818:Animals; D004285:Dogs; D005260:Female; D010646:Phentolamine / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects*; D012894:Sleep Stages / Q000187:drug effects; D012895:Sleep, REM / Q000187:drug effects; D013223:Statistics as Topic; D013565:Sympatholytics / Q000494:pharmacology*; D013997:Time Factors; D014851:Wakefulness / Q000187:drug effects*
D013565:Sympatholytics; D011433:Propranolol; D010646:Phentolamine