Regulation of enterochelin synthetase in Escherichia coli K-12.
Enterochelin synthetase activity is controlled by both repression and feed-back inhibition mechanisms. Inclusion of iron in growth media results in synthesis of all four (D, E, F and G) components of enterochelin synthetase being repressed. The specific inhibition of L-serine activation (partial reaction catalyzed by the F component) by the end products, ferric-enterochelin and 2,3-dihydroxybenzoylserine, is shown to inhibit overall enterochelin synthetase activity.
D015082:2,2'-Dipyridyl / Q000494:pharmacology; D002712:Chlorides; D004758:Enterobactin / Q000494:pharmacology; D004926:Escherichia coli / Q000201:enzymology*; D005246:Feedback; D005290:Ferric Compounds / Q000494:pharmacology; D010453:Peptide Synthases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012694:Serine / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology
D002712:Chlorides; D005290:Ferric Compounds; D004758:Enterobactin; D012694:Serine; D015082:2,2'-Dipyridyl; C014554:ferrienterochelin; C031920:2,3-dihydroxybenzoylserine; D010453:Peptide Synthases; C026269:2,3-dihydroxybenzoate - serine ligase; C024555:ferric chloride