Comparison of i.v. glycopyrrolate and atropine in the prevention of bradycardia and arrhythmias following repeated doses of suxamethonium in children.
The effectiveness of administration of glycopyrrolate 5 and 10 micrograms kg-1 and atropine 10 and 20 micrograms kg-1 i.v. immediately before the induction of anaesthesia, to prevent arrhythmia and bradycardia following repeated doses of suxamethonium in children, was studied. A control group was included for comparison with the lower dose range of glycopyrrolate and atropine. A frequency of bradycardia of 50% was noted in the control group, but this was not significantly different from the frequency with the active drugs. Bradycardia (defined as a decrease in heart rate to less than 50 beat min-1) was prevented when the larger dose of either active drug was used. It is recommended that either glycopyrrolate 10 micrograms kg-1 or atropine 20 micrograms kg-1 i.v. should immediately precede induction of anaesthesia, in children, if the repeated administration of suxamethonium is anticipated.
D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control*; D001285:Atropine; D001919:Bradycardia / Q000139:chemically induced / Q000517:prevention & control; D002648:Child; D004311:Double-Blind Method; D005260:Female; D006024:Glycopyrrolate; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007431:Intraoperative Complications; D008297:Male; D011229:Preanesthetic Medication; D011759:Pyrrolidines; D011897:Random Allocation; D013390:Succinylcholine / Q000009:adverse effects*
D011759:Pyrrolidines; D001285:Atropine; D013390:Succinylcholine; D006024:Glycopyrrolate