Microbial short-term assays with thiram in vitro.
The fungicide thiram was assayed in the following tests in vitro, with and without metabolic activation: (1) prophage lambda induction of Escherichia coli K12; (2) repair test in Salmonella typhimurium (strains TA1538 and TA1978); (3) induction of gene mutations in Aspergillus nidulans (methA1 suppressor induction). Thiram was positive in the repair test and in the A. nidulans forward-mutation test (4-6 fold increase) in the absence of metabolic activation. A slight increase was observed in prophage lambda induction with thiram in the presence of the metabolic activation system.
D001233:Aspergillus nidulans / Q000235:genetics; D010582:Bacteriophage lambda / Q000235:genetics; D001711:Biotransformation; D004260:DNA Repair / Q000187:drug effects*; D004926:Escherichia coli / Q000235:genetics; D008242:Lysogeny / Q000187:drug effects; D008862:Microsomes, Liver / Q000201:enzymology; D009152:Mutagenicity Tests; D009153:Mutagens; D012486:Salmonella typhimurium / Q000235:genetics; D013859:Thiocarbamates / Q000494:pharmacology*; D013893:Thiram / Q000494:pharmacology*
D009153:Mutagens; D013859:Thiocarbamates; D013893:Thiram