[Changes in the composition of phospholipids bound to supramolecular DNA of the thymus and liver in gamma-irradiated rats].
The composition of supramolecular DNA (SM DNA)-bound phospholipids (PL) of thymus and liver of intact rats and those 2 min, 2, 6 and 24 h after gamma-irradiation (9,7 Gy) was studied. In norm, supramolecular DNA of the thymus was shown to contain 6.7 micrograms PL/mg DNA, and that of the liver, 6.1 micrograms PL/mg DNA, the main components of PL being cardiolipin (CL) and phosphatidylethanolamine (PEA). Substantial changes were detected in the PL composition of SM DNA of gamma-irradiated rat organs. During the postirradiation period the concentration of PEA and CL in thymus SM DNA changed symbatically and irreversibly decreased to traces; whereas in SM DNA of the liver, their concentrations changed antibatically and decreased only to a definite level thus maintaining the necessary "lipid volume". It was shown that PL were not restored in SM DNA of the radioresistant liver.
D000818:Animals; D002855:Chromatography, Thin Layer; D004247:DNA / Q000032:analysis / Q000378:metabolism / Q000528:radiation effects*; D005720:Gamma Rays; D008099:Liver / Q000032:analysis / Q000378:metabolism / Q000528:radiation effects*; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism / Q000528:radiation effects*; D051381:Rats; D013950:Thymus Gland / Q000032:analysis / Q000378:metabolism / Q000528:radiation effects*; D013997:Time Factors
D010743:Phospholipids; D004247:DNA
Izmenenie sostava fosfolipidov, sviazannykh s nadmolekuliarnoĭ DNK timusa i pecheni gamma-obluchennykh krys.