Ampicillin trihydrate in foals: serum concentrations and clearance after a single oral dose.
Five foals from two to three days old were given a single oral dose of ampicillin trihydrate (20 mg/kg bodyweight [bwt]). Serum ampicillin concentrations were measured serially over a 24 h period. The study was repeated in the same foals at 16 to 21 days old. The mean peak serum ampicillin concentration at two to three days old was 5.0 micrograms/ml at 1 h after treatment; the mean peak serum concentration at 16 to 21 days old was 2.7 micrograms/ml at 2 h. The concentrations steadily declined and ampicillin was not detected in the serum from any of the foals by 24 h. Serum clearance averaged 17.7 ml/min/kg at two to three days and 35.8 ml/min/kg at 16 to 21 days.
D000667:Ampicillin / Q000097:blood / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000097:blood*; D005260:Female; D006736:Horses / Q000097:blood*; D007700:Kinetics; D008297:Male
D000667:Ampicillin