A model of irritant-induced bronchoconstriction in the spontaneously breathing guinea-pig.
1 Inhalation of an aqueous aerosol of citric acid caused bronchoconstriction in anaesthetized guinea-pigs which was abolished by bilateral vagal section. 2 Conscious guinea-pigs developed slow, laboured breathing within 90 s of exposure to citric acid aerosol. The onset of this pattern of breathing was delayed by prior aerosol administration of atropine, ipratropium bromide, isoprenaline and tetracaine. 3 The data suggest that exposure of guinea-pigs to citric acid may be a useful model of reflex bronchoconstriction.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001986:Bronchial Spasm / Q000139:chemically induced*; D005260:Female; D006168:Guinea Pigs; D009241:Ipratropium / Q000494:pharmacology; D007509:Irritants / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology; D008168:Lung / Q000502:physiology; D008297:Male; D013748:Tetracaine / Q000494:pharmacology
D007509:Irritants; D013748:Tetracaine; D001285:Atropine; D009241:Ipratropium; D007545:Isoproterenol