Loss of intrinsic striatal neurons after methylazoxymethanol acetate treatment in pregnant rats.
Treatment of pregnant rats with methylazoxymethanol (MAM) induces a marked microencephaly in the offspring. The striatum is one of the brain areas affected by treatment. We show that in striatum there is a 30% loss of dopamine (DA)-dependent adenylate-cyclase activity: this indicates that cells bearing type 1 DA receptors are affected by MAM treatment. Moreover, since kainic acid retains its neurotoxic activity, corticostriatal fibers do not seem to be affected, despite the dramatic reduction of cortex size.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001391:Azo Compounds / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000196:embryology / Q000201:enzymology; D005260:Female; D007608:Kainic Acid / Q000494:pharmacology; D008431:Maternal-Fetal Exchange; D008746:Methylazoxymethanol Acetate / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*
D001391:Azo Compounds; D011954:Receptors, Dopamine; D008746:Methylazoxymethanol Acetate; D000262:Adenylyl Cyclases; D007608:Kainic Acid