[Fosfomycin, a new antibiotic: in vitro activity compared with mezlocillin, cefuroxime and gentamicin].
In vitro investigations with fosfomycin, mezlocillin, cefuroxime, and gentamicin against staphylococci, enterobacteriaceae an pseudomonadaceae were carried out by Agar Dilution method on Mueller-Hinton agar. The fosfomycin breakpoint for the low dosage of 2-3 times 3 g per infusion daily was defined with 16 micro g/ml and for the high dosage of 2-3 times 5 g fosfomycin per infusion with 64 micro g/ml. At a concentration of 16 micro g/l fosfomycin more than 90% of the cultures of staph. aureus (penicillin-resistant), e. coli, proteus mirabilis an proteus vulgaris examined were inhibited. At a concentration of less than 64 micro g/ml fosfomycin 80 toi 100% of the cultures of serratia marcescens, klebsiella pneumoniae, enterobacter cloacae, proteus morgani et rettgeri and pseudomonas aeruginosa (gentamicin sensitive and resistant) were inhibited. Fosfomycin showed an absolute stability against many Beta-Lactamases of different bacterial species.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002444:Cefuroxime / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology*; D004755:Enterobacteriaceae / Q000187:drug effects; D005578:Fosfomycin / Q000494:pharmacology*; D005839:Gentamicins / Q000494:pharmacology*; D066298:In Vitro Techniques; D008802:Mezlocillin; D010403:Penicillin Resistance; D010406:Penicillins / Q000494:pharmacology*; D011548:Pseudomonadaceae / Q000187:drug effects; D013210:Staphylococcus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D005839:Gentamicins; D010406:Penicillins; D005578:Fosfomycin; D002444:Cefuroxime; D008802:Mezlocillin
Fosfomycin, ein neues Antibiotikum: In-vitro-aktivität im Vergleich mit Mezlocillin, Cefuroxim und Gentamicin.