Histamine as an endogenous antagonist of nicotinic ACh-receptor.
The mechanism of an inhibitory effect of histamine on the sensitivity of frog skeletal muscle endplate was analyzed by studying the dose-response relation between the quantity of ACh applied iontophoretically and the ACh-induced postsynaptic current (ACh current), and also the interaction between histamine and erabutoxin-b (ETX-b). The results obtained show that histamine, like curare, decreased the sensitivity of ACh-receptor in a competitive manner.
D000818:Animals; D001667:Binding, Competitive; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004870:Erabutoxins / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D009045:Motor Endplate / Q000187:drug effects*; D009433:Neural Inhibition; D009469:Neuromuscular Junction / Q000187:drug effects*; D011898:Ranidae; D011978:Receptors, Nicotinic / Q000187:drug effects* / Q000378:metabolism
D011978:Receptors, Nicotinic; D004870:Erabutoxins; D006632:Histamine; C032917:erabutoxin b