Activity of herbicolin A against Mycoplasma, Acholeplasma, Ureaplasma, and Spiroplasma species.
Herbicolin A, a novel acyl peptide antibiotic, inhibits the growth of the sterol-requiring Mycoplasma, Ureaplasma, and Spiroplasma species, with MICs varying from 1.5 to 100 micrograms/ml. With the exception of Acholeplasma modicum, all of the non-sterol-requiring species of the family Acholeplasmataceae were totally resistant to herbicolin A when tested on serum-containing medium but were inhibited to some extent on medium devoid of serum and any other source of sterol or fatty acids.
D000127:Acholeplasma / Q000187:drug effects; D000935:Antifungal Agents; D002784:Cholesterol / Q000378:metabolism; D008826:Microbial Sensitivity Tests; D009174:Mycoplasma / Q000187:drug effects; D009179:Mycoplasmatales / Q000187:drug effects*; D009842:Oligopeptides; D010455:Peptides / Q000494:pharmacology; D013149:Spiroplasma / Q000187:drug effects; D013261:Sterols / Q000378:metabolism; D014509:Ureaplasma / Q000187:drug effects
D000935:Antifungal Agents; D009842:Oligopeptides; D010455:Peptides; D013261:Sterols; C027099:herbicolin A; D002784:Cholesterol