Glomerulonephritis in leprosy.
A renal biopsy from a patient with lepromatous leprosy but no history of erythrema nodosum leprosum (ENL) showed histologic, immunofluorescent, and ultrastructural features typical of immune-complex glomerulonephritis. A literature review found reports of 187 renal biopsies from leprosy patients, with glomerulonephritis in 31% of the cases, and a variety of other renal lesions. This accumulated evidence demonstrates that, contrary to widely held opinion, there is no association between glomerulonephritis and a history of ENL. Furthermore, it suggests that glomerulonephritis in leprosy patients has a similar incidence in lepromatous and non-lepromatous cases. These observations have an important bearing on concepts regarding the pathogenesis of immune complex glomerulonephritis in leprosy and the humoral immune mechanisms in patients with leprosy.
D000936:Antigen-Antibody Complex; D001706:Biopsy; D004893:Erythema Nodosum; D005921:Glomerulonephritis / Q000150:complications* / Q000276:immunology; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology; D007668:Kidney / Q000473:pathology; D007918:Leprosy / Q000150:complications*; D008297:Male; D008875:Middle Aged
D000936:Antigen-Antibody Complex