Pharmacokinetics of intravenously administered desmosine in sheep.
The pharmacokinetics of desmosine following a 5 mg intravenous dose was determined in five sheep. The biological half-life (t 1/2 beta) of desmosine varied between 81-489 min. Urinary recovery of unchanged desmosine indicated that the compound is not extensively metabolized and that the primary route of elimination is via the kidney.
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D003895:Desmosine / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D006207:Half-Life; D007275:Injections, Intravenous; D007700:Kinetics; D008954:Models, Biological; D012756:Sheep
D000596:Amino Acids; D003895:Desmosine