The effect of heparin on endothelial stability.
Heparin in ultra low doses had a stabilizing effect on endothelial lining in rats. This effect was demonstrated as prevention of increases in counts of circulating endothelial cells after a standard intravenous citrate injection. The same effect of heparin was observed even with other provoking agents /adrenaline, hypotonic saline/. The duration of heparin effect was very prolonged, a 50% effect having been observed 5 hours after the administration. Subcutaneous heparin was effective only in relatively high doses and had a lower maximum effect compared with intravenous heparin.
D000818:Animals; D001772:Blood Cell Count; D001808:Blood Vessels / Q000187:drug effects; D002951:Citrates / Q000633:toxicity; D004727:Endothelium / Q000187:drug effects*; D004837:Epinephrine / Q000633:toxicity; D005260:Female; D006493:Heparin / Q000494:pharmacology*; D006494:Heparin Antagonists / Q000494:pharmacology; D007038:Hypotonic Solutions / Q000633:toxicity; D011479:Protamines / Q000494:pharmacology; D051381:Rats; D014652:Vascular Diseases / Q000139:chemically induced
D002951:Citrates; D006494:Heparin Antagonists; D007038:Hypotonic Solutions; D011479:Protamines; D006493:Heparin; D004837:Epinephrine