Ultrastructural and biochemical alterations induced by propranolol treatment in experimental myocardial ischaemia.
The effect of propranolol within the first ten days after a transient experimental myocardial ischaemia was investigated. As compared to the untreated control lot, the ultrastructural and biochemical lesions appeared to be much reduced and within reversible limits. Worthy of note was the slight affection of mitochondria revealed by the level of mitochondrial enzymes, the presence of lysosomal and phagolysosomal structures and capillaries of normal aspect, and the absence of cytolysis. The favourable effect of this beta-blocking drug might be attributed to its protective action on the cellular and capillary membrane systems.
D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy* / Q000473:pathology; D004285:Dogs; D008247:Lysosomes / Q000187:drug effects; D008854:Microscopy, Electron; D008929:Mitochondria, Heart / Q000187:drug effects; D009206:Myocardium / Q000201:enzymology / Q000648:ultrastructure*; D011433:Propranolol / Q000494:pharmacology* / Q000627:therapeutic use
D011433:Propranolol