Relief of asthma in two patients receiving danazol for endometriosis.
This paper describes two patients with endometriosis in whom treatment with danazol resulted in a concomitant remission of asthma. Neither patient reported an association of clinical symptoms with phases of their menstrual cycle. Whether the remission was fortuitous or related to suppression of the activity of the endometriotic tissue or to the ability of danazol to increase the serum levels of two protease inhibitors that are deficient in patients with asthma remains to be determined.
D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D003613:Danazol / Q000494:pharmacology / Q000627:therapeutic use*; D004715:Endometriosis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D011245:Pregnadienes / Q000627:therapeutic use*; D011460:Prostaglandins F / Q000502:physiology; D011480:Protease Inhibitors / Q000097:blood
D011245:Pregnadienes; D011460:Prostaglandins F; D011480:Protease Inhibitors; D003613:Danazol