Effect of ipratropium bromide on the action of bronchoactive agents.
The effect of (8r)-3 alpha-hydroxy-8-isopropyl-1 alpha H, 5 alpha H-tropanium-bromide-(+/-)-tropate (ipratropium bromide, Sch 1000), a newly developed anticholinergic agent, on the action of various bronchoactive agents was examined using isolated guinea pig strips. Ipratropium bromide has not only an anticholinergic effect but also has an attenuating one on the contractile responses induced by serotonin, prostaglandin F2 alpha, histamine and bradykinin, and has a potentiating one on the relaxation responses induced by prostaglandin E2, isoprenaline and adrenaline. Ipratropium bromide could be a useful therapeutic agent for patients with chronic obstructive lung diseases.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001286:Atropine Derivatives / Q000494:pharmacology*; D001920:Bradykinin / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects*; D015237:Dinoprost; D004347:Drug Interactions; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009241:Ipratropium / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011460:Prostaglandins F / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects
D001286:Atropine Derivatives; D011460:Prostaglandins F; D012701:Serotonin; D015237:Dinoprost; D009241:Ipratropium; D007545:Isoproterenol; D000109:Acetylcholine; D001920:Bradykinin