[Effect of protein metabolism inhibitors on parasympathetic innervation and cholinergic factors in the frog heart].
Protein exchange inhibitors levomycetine and cyclophosphane weakened parasympathetic effects. Levomycetine decreased the content (and synthesis) of acetylcholine (Ach) in heart homogenate while causing no changes of cholinesterase (ChE) activity. Cyclophosphane induced both the decrease of Ach content in the heart and the simultaneous reduction of ChE activity.
D000109:Acetylcholine / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D002701:Chloramphenicol / Q000494:pharmacology*; D002800:Cholinesterase Inhibitors; D002802:Cholinesterases / Q000378:metabolism*; D003520:Cyclophosphamide / Q000494:pharmacology*; D006321:Heart / Q000294:innervation*; D066298:In Vitro Techniques; D009206:Myocardium / Q000648:ultrastructure*; D011898:Ranidae; D011950:Receptors, Cholinergic / Q000187:drug effects*; D013347:Subcellular Fractions / Q000378:metabolism; D013997:Time Factors; D014630:Vagus Nerve / Q000187:drug effects*
D002800:Cholinesterase Inhibitors; D011950:Receptors, Cholinergic; D002701:Chloramphenicol; D003520:Cyclophosphamide; D002802:Cholinesterases; D000109:Acetylcholine
Vliianie ingibitorov belkovogo obmena na parasimpaticheskuiu innervatsiiu i kholinergicheskie faktory serdtsa liagushki.