Augmentation of flap survival by thymoxamine.
An experimental study in rats showed that the use of the alpha-receptor antagonist, thymoxamine could increase the blood supply to an ischaemic flap. Thymoxamine has a very short half-life, must be given frequently to be effective, but has the significant advantage that its action can be reversed by noradrenaline. When a flap is in trouble, alpha-receptor blockade by thymoxamine might help dramatically in its salvage.
D000818:Animals; D006085:Graft Survival / Q000187:drug effects*; D008297:Male; D013948:Moxisylyte / Q000008:administration & dosage / Q000494:pharmacology*; D011184:Postoperative Period; D011292:Premedication; D051381:Rats; D011919:Rats, Inbred Strains; D016038:Skin Transplantation; D013524:Surgical Flaps
D013948:Moxisylyte