Improved red cell survival in patients with chronic subclinical haemolysis due to artificial heart valve. Observations after in vitro treatment of the cells with potassium cyanate.
Red cell survival was studied with use of Chromium-51 isotope and standard haematologic tests of haemolysis. The study comprised 30 patients with normally functioning single artificial heart valves of various types. They were investigated on 2 or 3 occasions. Red cells labelled with Cr-51 were treated for 30 min with potassium cyanate (0.5 mg/100 ml) in 5% invertose or with only 5% invertose. The mean red cell survival without cyanate treatment was 25 (+/- 4.2) days. Following cyanate treatment this figure improved to 31 (+/-4.8) days. Low-grade chronic intravascular haemolysis was associated with all the valve types. Abnormal results were found in 67% and 62% of the tests in patients with ball-type valve (deBakey and Starr-Edwards, respectively). The figures for tilting disc values (Lillehei-Kaster and Björk-Shiley) were 51 and 45.5%, while Carpentier-Edwards bioprosthetic valves gave 15.5% abnormal test results. The findings thus suggested that ball valves are more haemolytic than tilting disc valves, which in turn are more haemolytic than tissue valves.
D000743:Anemia, Hemolytic / Q000209:etiology* / Q000517:prevention & control; D001021:Aortic Valve; D002860:Chromium Radioisotopes; D003485:Cyanates / Q000494:pharmacology*; D004905:Erythrocyte Aging / Q000187:drug effects*; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008943:Mitral Valve; D011474:Prosthesis Design
D002860:Chromium Radioisotopes; D003485:Cyanates; C024835:potassium cyanate