[Effect of aminoguanidine sulfate on the hepatic level of polyamines after partial hepatectomy in rats].
The injection of amino-guanidine sulfate, which is a diamine-oxydase inhibitor to Wistar rats partially hepatectomized modifies the putrescine, spermidine and spermine liver concentrations, estimated by thin layer chromatography after dansylation. The three polyamines reach a peak three hours after the beginning of the treatment, then decrease six hours later, especially for putrescine and spermine. Forty eight hours later, the spermidine rate increase again to reach a level superior to that of animals which were only hepatectomized, whereas putrescine and spermine levels remain until about the fourth day inferior to those of control animals. Contrary to shamoperated rats, those injected with amino-guanidine sulfate show higher polyamine concentrations. These observations probably show a reduction of the activity of the diamine oxidase under the influence of amino-guanidine sulfate. According to those results, the action of amino-guanidine sulfate previously observed on the hyperplasic component of liver regeneration, doesn't seem to have an effect upon diamine oxidase.
D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors; D000818:Animals; D006146:Guanidines / Q000494:pharmacology*; D006498:Hepatectomy; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008115:Liver Regeneration; D008297:Male; D011073:Polyamines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D006146:Guanidines; D011073:Polyamines; D006631:Amine Oxidase (Copper-Containing); C004479:pimagedine
Action du sulfate d'aminoguanidine sur les taux hépatiques de polyamines après hépatectomie partielle chez le rat.