Absence of genetic and cytogenetic effects in mice treated by the organophosphorus insecticide parathion, its methyl analogue, and paraoxon.
Male mice (Q strain) received a single i.p. injection of 3 organophosphorus compounds: ethylparathion (10 mg/kg), its methyl analogue (methylparathion, 10 mg/kg), or its phosphate derivative (ethylparaoxon, 0.3 mg/kg). The number of chromosome aberrations observed in bone marrow cells and spermatogonia, and the frequency of pre- and postimplantation foetal lethality obtained in a dominant lethal mutation assay, did not conclusively prove that the tested compounds produced a mutagenic effect.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D005260:Female; D005799:Genes, Dominant / Q000187:drug effects*; D005804:Genes, Lethal / Q000187:drug effects*; D008297:Male; D008741:Methyl Methanesulfonate / Q000633:toxicity; D008743:Methyl Parathion / Q000633:toxicity*; D051379:Mice; D009154:Mutation; D010261:Paraoxon / Q000633:toxicity*; D010278:Parathion / Q000031:analogs & derivatives* / Q000633:toxicity*; D011247:Pregnancy; D013093:Spermatogonia / Q000187:drug effects; D013997:Time Factors
D008743:Methyl Parathion; D010278:Parathion; D008741:Methyl Methanesulfonate; D010261:Paraoxon