Plasmin--alpha 2-antiplasmin complex as an indicator of in vivo fibrinolysis.
alpha 2-Antiplasmin is the principal plasma inhibitor of plasmin, with which it rapidly and irreversibly forms a complex. The simple technique of crossed immunoelectrophoresis against antiserum to alpha 2-antiplasmin has been applied to detect plasmin-alpha 2-antiplasmin complex in plasma. The presence of this complex is demonstrated in patients in whom overactive fibrinolysis was the only or major contributor to severe haemorrhagic disorders arising spontaneously.
D000328:Adult; D005260:Female; D005341:Fibrinolysin / Q000032:analysis*; D005342:Fibrinolysis; D006470:Hemorrhage / Q000175:diagnosis*; D006487:Hemostasis; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D008297:Male; D008875:Middle Aged; D000979:alpha-2-Antiplasmin / Q000032:analysis*
D000979:alpha-2-Antiplasmin; D005341:Fibrinolysin