Comparison of rat plasma glycoprotein composition with biochemical activity and morphology of liver Golgi apparatus in streptozotocin diabetes treated with insulin.
The seromucoid level and its neutral sugar composition were studied and the results compared with Golgi-enriched membrane UDP-Gal leads to GlcNAc transferase activity and the morphology of the liver Golgi apparatus in situ. Four groups of rats were studied: 1. control, 2. streptozotocin diabetic, 3. insulin treated, and 4. streptozotocin diabetic and insulin treated. In many respects a correlation was observed between the seromucoid level and composition and the biochemical and morphological properties and composition and the biochemical morphological properties of the Golgi apparatus.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006056:Golgi Apparatus / Q000201:enzymology* / Q000648:ultrastructure; D007328:Insulin / Q000627:therapeutic use; D007788:Lactose Synthase / Q000378:metabolism*; D008099:Liver / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D009237:N-Acetyllactosamine Synthase / Q000378:metabolism*; D009961:Orosomucoid / Q000097:blood*; D051381:Rats; D013311:Streptozocin
D007328:Insulin; D009961:Orosomucoid; D013311:Streptozocin; D007788:Lactose Synthase; D009237:N-Acetyllactosamine Synthase