Hemodynamic changes in human anaphylaxis.
Human anaphylactic reactions are usually unexpected and catastrophic. Therefore, opportunities to record the physiologic changes that occur are uncommon. A patient is described who experienced an anaphylactic reaction to a penicillin drug while being monitored in an intensive care unit for ischemic heart disease. Hemodynamic monitoring indicated that the decrease in cardiac output was most likely due to a decrease in venous return. In addition, this patient's previous reactions to other penicillins demonstrated that variations in the clinical manifestations of systemic anaphylaxis can occur within the same person.
D000368:Aged; D000707:Anaphylaxis / Q000139:chemically induced / Q000503:physiopathology*; D001794:Blood Pressure; D002302:Cardiac Output; D003327:Coronary Disease / Q000503:physiopathology; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D006439:Hemodynamics; D006801:Humans; D009254:Nafcillin / Q000009:adverse effects; D010406:Penicillins / Q000009:adverse effects; D011654:Pulmonary Edema / Q000503:physiopathology; D011669:Pulmonary Wedge Pressure; D012128:Respiratory Distress Syndrome / Q000503:physiopathology; D013997:Time Factors; D014655:Vascular Resistance
D010406:Penicillins; D009254:Nafcillin