Recurrent meningococcal meningitis. A case report.
A 17-year-old Coloured youth presented at Tygerberg Hospital on six occasions between 1978 and 1981. He was admitted three times for meningococcal meningitis and three times for a meningitic illness clinically suggestive thereof. He had been admitted twice before to the City Hospital, Cape Town, in 1966 and 1968, for presumed meningococcal meningitis. He was fully evaluated in the outpatient department and found to have no detectable total haemolytic complement activity. There was no evidence of classic or alternative pathway activation. He has been tentatively designated as having a deficiency in the C6 or C8 components of the terminal membrane attack mechanism of the complement cascade.
D000293:Adolescent; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D003165:Complement System Proteins / Q000032:analysis*; D006801:Humans; D008297:Male; D008585:Meningitis, Meningococcal / Q000276:immunology*; D012008:Recurrence
D003176:Complement C3; D003181:Complement C4; D003165:Complement System Proteins