The cyclic motor activity of the ovine gut: its reset at a faster rhythm.
In adult sheep, the frequency of the migrating motor complexes (MMC) was increased by the duodenal administration of methysergide, but not affected by other 5-HT1 or 5-HT2 antagonists. This reset of the MMC pattern at a faster rhythm suggests a selective action on the enteric neuronal serotoninergic mechanism modulating the pacing of the gut cyclic motor activity.
D000818:Animals; D001683:Biological Clocks / Q000187:drug effects*; D004386:Duodenum / Q000502:physiology; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007583:Jejunum / Q000502:physiology; D008784:Methysergide / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology*; D012756:Sheep / Q000502:physiology*; D014628:Vagotomy
D012702:Serotonin Antagonists; D008784:Methysergide