Elevated erythrocyte adenosine deaminase activity in Down's syndrome.
Erythrocyte ADA activity was measured in 29 cases of Down's syndrome and in 29 age- and sex-matched controls subjects. The mean activity (+/- S.D.) of ADA in Down's syndrome was 1883 +/- 463 mU/g Hb (37 degrees C) and 1361 +/- 294 mU/g Hb in the controls. The difference was statistically significant (p less than 0.001). The purine metabolism of Down's syndrome patients is discussed.
D000243:Adenosine Deaminase / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004314:Down Syndrome / Q000201:enzymology*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009700:Nucleoside Deaminases / Q000378:metabolism*; D011687:Purines / Q000378:metabolism
D011687:Purines; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase