T suppressor cells activated by anti-Tsud serum are Igh-V-restricted.
T suppressor (Ts) cells can be activated by alloantiserum directed against Tsud, a cell surface marker associated with the Ts cell receptor for antigen. These cells are restricted in their ability to transfer suppression in allotype-congenic mice. Transfer of suppression requires matching of donor recipient mice at Igh-V loci, but recipient mice need not share the Tsud allele nor the same allotype as the activated Ts cells. Genes linked to the kappa light chain locus apparently do not affect this transfer.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D000950:Antigens, Ly / Q000235:genetics; D001666:Binding Sites, Antibody / Q000235:genetics*; D008040:Genetic Linkage; D006462:Hemolytic Plaque Technique; D007106:Immune Sera / Q000494:pharmacology; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007147:Immunoglobulin Light Chains / Q000235:genetics; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D007519:Isoantigens / Q000235:genetics*; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D000950:Antigens, Ly; D007106:Immune Sera; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007135:Immunoglobulin Variable Region; D007519:Isoantigens