Immunohistochemically detectable vitamin D-dependent calcium-binding protein is reduced in cerebellum of diabetic subjects.
The immunohistochemical distribution of the vitamin D-dependent calcium-binding protein (CaBP) was studied in the cerebellar vermis of 14 adult type (NIDDM) diabetic and 13 nondiabetic human subjects. In both groups, CaBP-immunoreactive material was found in Purkinje cells and in axons of the cortical white matter, but, when compared with controls, the positive structures had a significantly (P less than 0.001) reduced volume density in 12 of the 14 diabetic subjects. The reduction of the volume density of CaBP-positive structures in diabetic subjects was not due to an overall reduced volume of the molecular layer or of the cortical white matter. These results complement previous reports of a reduction of CaBP levels in duodenum and kidney of diabetic subjects.
D000368:Aged; D001369:Axons / Q000648:ultrastructure; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D003929:Diabetic Neuropathies / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011689:Purkinje Cells / Q000648:ultrastructure; D064030:S100 Calcium Binding Protein G / Q000378:metabolism*
D002135:Calcium-Binding Proteins; D064030:S100 Calcium Binding Protein G