Type II collagen-induced arthritis in mice. II. Passive transfer and suppression by intravenous injection of anti-type II collagen antibody or free native type II collagen.
The passive transfer of high levels of anti-type II collagen antibody from mice with type II collagen-induced arthritis may transfer arthritis to syngeneic recipient animals. However, the transfer of either arthritogenic or sub-arthritogenic doses of polyclonal anti-type II collagen antibody, or non-arthritogenic monoclonal anti-type II collagen antibody may protect mice against the subsequent induction of arthritis by type II collagen. A protective effect was also observed in mice given free native type II collagen intravenously before the administration of collagen in an arthritogenic protocol.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001168:Arthritis / Q000276:immunology*; D001169:Arthritis, Experimental / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D002645:Chickens; D003094:Collagen / Q000276:immunology*; D003429:Cross Reactions; D007116:Immunization, Passive; D007165:Immunosuppression Therapy; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D003094:Collagen