Modifications of brain steroidogenesis and plasma steroids after p-chlorophenylalanine-methyl-ester treatment in male rats and rabbits.
The effect of p-chlorophenylalanine (p-CPA) on testosterone (T) hypothalamic metabolism and on plasma levels of T, estradiol (E2) and corticosterone (B) was studied in male rats and rabbits: both were sacrificed 48 hours after the last injection. In both rats and rabbits a significant increase in T leads to E2 transformation (aromatization) was evident after p-CPA treatment. This increase could be responsible for the stimulatory effect on sexual behavior which has been described in literature following p-CPA administration. Moreover p-CPA caused a decrease of circulating T and E2 in both species.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003345:Corticosterone / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D010134:Fenclonine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013256:Steroids / Q000096:biosynthesis* / Q000097:blood; D013739:Testosterone / Q000378:metabolism
D013256:Steroids; C020261:4-chlorophenylalanine methyl ester; D013739:Testosterone; D004958:Estradiol; D010134:Fenclonine; D003345:Corticosterone