Effects of cyproterone acetate on growth and androgen metabolism of rat ventral prostate transplants.
Cyproterone acetate (CA0 (10 or 20 mg kg-1 daily for 5 days) injected into castrate rats supplemented with testosterone propionate (TP) caused a significant decrease in ventral prostate weights in situ; no inhibitory effects were noted in transplant weights. CA failed to significantly inhibit DNA in either the in situ prostate or transplant, but his anti-androgen caused a significant decrease in the formation of 3H-dihydrotestosterone and 3H-androstanediol from radioactive testosterone in the in situ organ. Histologically, CA caused a decrease in epithelial cell secretory activity.
D000728:Androgens / Q000378:metabolism*; D000818:Animals; D002369:Castration; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017373:Cyproterone Acetate; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism* / Q000637:transplantation; D051381:Rats; D011916:Rats, Inbred F344; D013739:Testosterone / Q000494:pharmacology
D000728:Androgens; D013739:Testosterone; D017373:Cyproterone Acetate; D003534:Cyproterone