[Nitrosomethylurea in the treatment of patients with disseminated cutaneous melanoma].
Thirty cases of disseminated skin melanoma were treated with nitrosomethylurea which was given in 2-3 week courses (10 mg/kg twice a week each) at 1-2 month intervals. Complete response with a recurrence-free period of 6 months to over 3 years was registered in 3 patients (10%). A decrease in tumor size by more than 50% within 5-12 months was secured in 6 patients (20%). The responders survived longer than those in whom the treatment had failed. Side-effects were moderate and reversible. Nitrosomethylurea should be widely used in treatment of skin melanoma.
D000328:Adult; D000368:Aged; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000188:drug therapy* / Q000401:mortality; D008770:Methylnitrosourea / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009607:Nitrosourea Compounds / Q000627:therapeutic use*; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000401:mortality; D013997:Time Factors
D009607:Nitrosourea Compounds; D008770:Methylnitrosourea
Nitrozometilmochevina v lechenii bol'nykh disseminirovannoĭ melanomoĭ kozhi.