Response of the upper respiratory tract of the rat to white spirit vapour.
The threshold limit value (TLV) adopted by industry for white spirit is that of Stoddard's solvent and is currently set at 100 ppm (525 mg/m3). Exposure of rats to atmospheres containing an average of 214 mg/m3, 4 h/day, for 4 consecutive days resulted in irritation of the membranes lining the upper respiratory tract but only minimal signs of lung injury. Histopathological changes were observed in the nasal cavity, trachea and larynx and included loss of cilia, mucous and basal cell hyperplasia and squamous metaplasia. These results suggest that in man exposure to white spirit at or around the TLV may result in irritation of the upper respiratory tract.
D000818:Animals; D005260:Female; D006838:Hydrocarbons / Q000633:toxicity*; D008452:Maximum Allowable Concentration; D051381:Rats; D012119:Respiration / Q000187:drug effects; D012137:Respiratory System / Q000187:drug effects* / Q000473:pathology; D012997:Solvents / Q000633:toxicity*; D013997:Time Factors
D006838:Hydrocarbons; D012997:Solvents; C013089:ligroin