Effect of a mercurial ayurvedic drug (kajyoli) on the ion concentration and respiratory activity in brain, liver and kidney of the albino rat.
The effect of a mercurial ayurvedic drug (kajyoli), on the concentration of Na+, K+ and Ca2+ in rat liver, kidney and brain, and on the respiratory activity of these tissues is reported. The doses used were 20 mg and 40 mg X day-1 X kg-1 body wt. daily for 30 days, the lower level being equivalent to the human dose. A marked dose-dependent decrease in respiratory activity occurred in the three tissues. The only significant changes seen in the ion concentration were a decrease in Na+ at the higher dose level in the kidney and a dose-dependent decrease in Ca2+ in the liver.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D002118:Calcium / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D008515:Medicine, Ayurvedic; D008628:Mercury / Q000633:toxicity*; D010101:Oxygen Consumption / Q000187:drug effects*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism
C042473:kajyoli; D012964:Sodium; D008628:Mercury; D011188:Potassium; D002118:Calcium