[Effect of methylcobalamine on the processes of posttraumatic regeneration of the salivary glands].
Experiments on rats were made to study membrane potentials (MP) of secretory cells of the salivary glands, the content of biogenic amines and lactate dehydrogenase (LDH) isozymes of the salivary gland tissue in trauma after pretreatment with methylcobalamine. Twenty-four hours after trauma the salivary gland showed a decrease in the content of LDH aerobic fractions, the lowering of noradrenaline concentration with no changes in the MP of glandular cells outside the zone of injury. Administration of cobalamine did not cause any changes in the parameters under study. There was an increase in the polarization level of acinar and duct cells, normalization of noradrenaline content, and a rise of adrenalin concentration with persistent reduction in aerobic fractions of LDH in salivary gland trauma after pretreatment with methylcobalamine. It is concluded that methylcobalamine administration may have a therapeutic effect in salivary gland trauma.
D000818:Animals; D004837:Epinephrine / Q000378:metabolism; D005260:Female; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012038:Regeneration / Q000187:drug effects*; D013363:Submandibular Gland / Q000293:injuries / Q000502:physiology*; D014805:Vitamin B 12 / Q000031:analogs & derivatives* / Q000494:pharmacology
D007527:Isoenzymes; C019476:mecobalamin; D007770:L-Lactate Dehydrogenase; D014805:Vitamin B 12; D009638:Norepinephrine; D004837:Epinephrine
Deĭstvie metilkobalamina na protsessy posttravmaticheskoĭ regeneratsii sliunnykh zhelez.