Nuclear medicine studies in evaluation of skeletal lesions in children with histiocytosis X.
Radiographs were compared with 99mTc scans of the bones and bone marrow as well as 67Ga-citrate scans to evaluate their sensitivity in identifying skeletal lesions in 21 children with histiocytosis X. Seven of 20 bone scans were completely normal in patients with extensive radiographic evidence of skeletal disease. In only one patient were bone scan changes demonstrated prior to radiographic abnormalities. None of the lesions was "cold" on the bone scans. 99mTc-sulfur colloid bone marrow scans and 67Ga-citrate whole-body scans were not valuable. Radiographic survey of the skeleton should be the primary diagnostic test employed in patients with histiocytosis X who have suspected skeletal lesions. Bone scans should be obtained only when the radiographs are normal or equivocal.
D001847:Bone Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D001853:Bone Marrow / Q000000981:diagnostic imaging; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002648:Child; D002675:Child, Preschool; D004164:Diphosphonates; D012968:Etidronic Acid; D005188:False Negative Reactions; D005260:Female; D005710:Gallium Radioisotopes; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000000981:diagnostic imaging*; D006801:Humans; D007223:Infant; D008297:Male; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D013455:Sulfur; D013667:Technetium; D013669:Technetium Tc 99m Medronate; D013671:Technetium Tc 99m Sulfur Colloid
D004164:Diphosphonates; D005710:Gallium Radioisotopes; D015609:Organotechnetium Compounds; C019561:technetium Tc 99m etidronate; D013671:Technetium Tc 99m Sulfur Colloid; D013455:Sulfur; D013667:Technetium; D012968:Etidronic Acid; D013669:Technetium Tc 99m Medronate