Dose response of monoclonal tumor induction with 3-methylcholanthrene in mosaic mice.
Inductions of monoclonal tumors, as judged by their single phenotype of phosphoglycerate kinase, in mice with X-chromosome inactivation mosaicism, were observed after s.c. injection of doses of 3-methylcholanthrene of 0.005 to 2 mg/mouse. The tumors induced (79% fibrosarcomas) exhibited the single-enzyme phenotype with 93% frequency at the lowest dose and with 57% frequency at the highest dose, indicating the dependence of monoclonal tumor induction on the dose of carcinogen.
D000818:Animals; D008748:Methylcholanthrene / Q000633:toxicity*; D051379:Mice; D008817:Mice, Mutant Strains; D009030:Mosaicism; D009374:Neoplasms, Experimental / Q000235:genetics / Q000473:pathology*; D010641:Phenotype; D010735:Phosphoglycerate Kinase / Q000235:genetics
D008748:Methylcholanthrene; D010735:Phosphoglycerate Kinase