[Formation of endogenous pyrogen by mononuclear phagocytes].
Production of endogenous pyrogen by human and rabbit blood monocytes in response to stimulation with agents of different origin was studied by inhibitory analysis under comparable conditions. Actinomycin D and cytochalasin B were applied. New evidence was obtained about an important role in the mechanism of activation of mononuclear phagocytes of initial interaction between a stimulating agent and the leukocyte membrane and of the biphasic process of endogenous pyrogen production.
D000818:Animals; D005260:Female; D006801:Humans; D008297:Male; D009000:Monocytes / Q000378:metabolism*; D010586:Phagocytes / Q000378:metabolism*; D011749:Pyrogens / Q000097:blood*; D011817:Rabbits
D011749:Pyrogens
Obrazovanie éndogennogo pirogena mononuklearnymi fagotsitami.