Target neurons for [3H]corticosterone in the rat spinal cord.
Rats were injected with [3H]corticosterone and their spinal cords processed for autoradiography. Nuclear concentration of the tritiated steroid was observed in motor neurons in cervical, thoracic, lumbar, and sacral regions. Nuclear concentrations of [3H]corticosterone was also observed in certain neurons of laminae VII and III in all levels of the spinal cord. Injection of unlabeled corticosterone 5 min before the [3H]corticosterone injection abolished the nuclear concentration of the adrenal steroid. These results provide the morphological basis for a direct genomic action of corticosterone in spinal motor neurons and in neurons of laminae III and VII.
D000315:Adrenalectomy; D000818:Animals; D001345:Autoradiography; D002467:Cell Nucleus / Q000378:metabolism; D003345:Corticosterone / Q000378:metabolism* / Q000494:pharmacology; D005938:Glucocorticoids / Q000627:therapeutic use; D008297:Male; D009046:Motor Neurons / Q000378:metabolism*; D009157:Myasthenia Gravis / Q000188:drug therapy; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism*
D005938:Glucocorticoids; D003345:Corticosterone