Gentamicin dosing in the newborn. Use of a one-compartment open pharmacokinetic model to individualize dosing.
Gentamicin 2.5 mg/kg was given to 60 term and preterm neonates. Serum gentamicin concentrations were determined at 1, 7 and 11 h postinfusion. Linear regression analysis was used to determine half-life and volume of distribution. From these data a new dosing regimen and a predicted steady-state peak and trough gentamicin concentration were determined for each neonate. The predicted peak and trough were compared to a measured peak or trough drawn at least 48 h later. Criteria for successful peaks were met in 93% of the patients, while criteria for successful troughs were met in 83%. Individualized gentamicin dosing in the newborn based on a one-compartment open pharmacokinetic model is a useful clinical tool in predicting peak and trough gentamicin concentrations.
D005839:Gentamicins / Q000008:administration & dosage* / Q000378:metabolism / Q000627:therapeutic use; D006207:Half-Life; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy*; D007700:Kinetics; D008956:Models, Chemical
D005839:Gentamicins