[Experimental evidence of the cholinoreactivity of tissue basophils of the dura mater of the brain in the rat].
The mast cells of the rat dura mater were taken at different periods of functional activity. Their reaction to injection of acetylpholine, atropine was studied. The change in the functional activity of the mast cells was also studied when acetylcholine was injected after a single administration of atropine and after a prolonged atropinization. When acetylcholine is injected, the number of degranulated mast cells is increasing, when atropine is injected--there is an abatement of their functional activity. After a preliminary single atropinization, there is no reaction of the mast cells to acetylcholine. When acetylcholine is injected, after a prolonged atropinization, the phenomenon of tolerance appears and the number of degradating cells increases. The reaction to administration of various pharmacological preparations depends on the degree of the initial functional activity of the mast cells. Acetylcholine sharply increases, and atropine essentially decreases the active function of the cells, when the initial functional activity of the mast cells is minimal; regardless the initial state of the mast cells, acetylcholine, injected on the background of atropine, does not change the active function of the cells. Restoration of the active function of the cells after a prolonged atropinization occurs quicker and is more effective in the mast cells with a maximal initial functional activity. Certain pharmacological evidences have been obtained on presence of M-cholinoreceptors in the mast cells of the rat dura mater.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D003594:Cytoplasmic Granules / Q000187:drug effects; D004388:Dura Mater / Q000166:cytology*; D008407:Mast Cells / Q000032:analysis / Q000187:drug effects* / Q000502:physiology; D010275:Parasympathetic Nervous System / Q000502:physiology; D051381:Rats; D011976:Receptors, Muscarinic / Q000032:analysis
D011976:Receptors, Muscarinic; D001285:Atropine; D000109:Acetylcholine
Eksperimental'nye dokazatel'stva kholinoreaktivnosti tkanevykh bazofilov tverdoĭ obolochki golovnogo mozga krys.