Antimicrobial spectrum of Win 49375.
Win 49375 had excellent activity against members of the family Enterobacteriaceae and staphylococcal species. Its activity against Pseudomonas aeruginosa was equal to that of gentamicin. Win 49375 had moderate activity against clostridia but little against Bacteroides fragilis. The drug showed a marked inoculum effect at 10(8) CFU/ml and a slight decrease in potency at pH 5.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001420:Bacteria, Aerobic / Q000187:drug effects; D001421:Bacteria, Anaerobic / Q000187:drug effects; D002939:Ciprofloxacin / Q000031:analogs & derivatives*; D003470:Culture Media; D024841:Fluoroquinolones; D006863:Hydrogen-Ion Concentration; D008826:Microbial Sensitivity Tests; D011804:Quinolines / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D003470:Culture Media; D024841:Fluoroquinolones; D011804:Quinolines; D002939:Ciprofloxacin; C040691:amifloxacin