Effect of lidocaine on in vitro absorption of glucose in jejunal and ileal segments of the rat.
The influence of lidocaine on the intestinal glucose absorption was investigated on Tyrode-perfused isolated intestinal segments of the rat. In ileal segments the transmural transfer of glucose decreased with increasing lidocaine concentration (5 X 10(-9) -2 X 10(-4) mol/l), whereas the water movement was unaffected. No inhibitory effect on glucose and water absorption was observed in the proximal jejunum.
D000818:Animals; D005947:Glucose / Q000378:metabolism*; D007082:Ileum / Q000378:metabolism; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000378:metabolism; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D008012:Lidocaine; D005947:Glucose