[The problem of enhancing the biological action of ionizing radiations. Glucose as an agent for increasing the radiosensitivity of Ehrlich ascitic carcinoma cells in vitro].
The effect of short-term incubation of Ehrlich ascites tumor cells in a medium containing excess glucose on their radiosensitivity was studied with a reference to the growth of tumors of ascitic and solid forms. It was shown that the incubation of cells with glucose, being accompanied by a change in pH of the suspension, caused, by itself, only a slight increase in the duration of the latent period of solid tumor formation and in the life-span of mice with ascitic tumors but increased considerably the lethal effect of radiation, as was estimated by the above mentioned criteria and the percentage of inoculated tumors.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000532:radiotherapy*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005947:Glucose / Q000627:therapeutic use*; D006863:Hydrogen-Ion Concentration; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D011836:Radiation Tolerance; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*
D011838:Radiation-Sensitizing Agents; D005947:Glucose
Problema usileniia biologicheskogo deĭstviia ioniziruiushchikh izlucheniĭ. Gliukoza kak sredstvo povysheniia radiochuvstvitel'nosti kletok astsitnoĭ kartsinomy Erlikha in vitro.