The up-and-down method for the determination of nociceptive thresholds in rats.
The up-and-down method applied to the jump-flinch technique provided estimates of shock thresholds for jump and flinch with high statistical efficiency and a much reduced amount of experimentation compared with traditional methods. Reproducible results were obtained after repeated testing and flinch and jump thresholds were significantly increased by treatment with morphine or oxotremorine.
D000818:Animals; D004597:Electroshock; D007279:Injections, Subcutaneous; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology; D009619:Nociceptors / Q000502:physiology*; D010095:Oxotremorine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012684:Sensory Thresholds
D010095:Oxotremorine; D009020:Morphine