Little effect of dimethyl sulfoxide on blood-brain barrier to dopamine.
Rats were treated with dimethyl sulfoxide (DMSO) intraperitoneally or intravenously, and simultaneously with dopamine (DA). The presence of DMSO resulted in small or no increases in brain levels of DA or its metabolites.
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000378:metabolism*; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D008297:Male; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D010293:Pargyline; D004298:Dopamine; D004121:Dimethyl Sulfoxide