Effects of salbutamol, ipratropium bromide and disodium cromoglycate on breathlessness induced by exercise in normal subjects.
1 Healthy volunteers undertook submaximal graded exercise while objective measurements of cardio-respiratory function were made and breathlessness was assessed with serial visual analogue scales. 2 A useful and consistent relationship existed between breathlessness and ventilation for individual subjects. 3 Drugs were examined in this system to test whether they modified the relationship between ventilation and breathlessness such that less breathlessness occurred for a given level of ventilation. 4 Salbutamol, ipratropium bromide and disodium cromoglycate given by inhalation did not reduce breathlessness in healthy subjects during exercise.
D000328:Adult; D000420:Albuterol / Q000494:pharmacology / Q000627:therapeutic use*; D001286:Atropine Derivatives / Q000627:therapeutic use*; D004205:Cromolyn Sodium / Q000494:pharmacology / Q000627:therapeutic use*; D004417:Dyspnea / Q000188:drug therapy*; D006801:Humans; D009241:Ipratropium / Q000494:pharmacology / Q000627:therapeutic use*; D005082:Physical Exertion; D012119:Respiration / Q000187:drug effects; D012129:Respiratory Function Tests
D001286:Atropine Derivatives; D009241:Ipratropium; D004205:Cromolyn Sodium; D000420:Albuterol