Linkage of Pgm-3 in the house mouse and homologies of three phosphoglucomutase loci in mouse and man.
The discovery of a third phosphoglucomutase locus (Pgm-3) in the house mouse is reported. Three alleles are recognized on the basis of differences in electrophoretic mobility and enzymatic activity. Pgm-3A (fast mobility and high activity) is present in inbred strain C57BL/10J and 24 other strains; Pgm-3b (slow mobility and high activity) is present in LP/Pas and six other strains; and Pgm-3c (no detectable activity in any tissue tested) is present in strain DBA/2J and 14 other strains. Seventy-four recombinant inbred strains derived from progenitors that differed at Pgm-3 were used to study genic linkage. Pgm-3 is on chromosome 9 and is linked to Sep-1, d, Mod-1, and Ltw-3. Gene order and recombination frequencies are estimated as d 3.8 +/- 1.8%. Pgm-3 2.3 +/- 1.2% Mod-1. Substrate specificities and cofactor requirements show that mouse Pgm-1 is homologous with human Pgm-2, mouse Pgm-2 with human Pgm-1, and mouse Pgm-3 with human Pgm-3.
D000483:Alleles; D000818:Animals; D008040:Genetic Linkage; D006579:Heterozygote; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D008285:Major Histocompatibility Complex; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype; D010733:Phosphoglucomutase / Q000235:genetics*; D013045:Species Specificity
D007527:Isoenzymes; D010733:Phosphoglucomutase