A family with sickle cell trait and hereditary spherocytosis.
The rare combination of sickle cell trait with hereditary spherocytosis in a Sudanese family is reported. The splenic hypofunction and fibrosis as a result of sickling has ameliorated the clinical course of the 35 year old father. The symptoms of a six years old son seem to be getting milder with age too. The family is managed conservatively and splenectomy was not required.
D000328:Adult; D000755:Anemia, Sickle Cell / Q000235:genetics*; D002648:Child; D005260:Female; D006454:Hemoglobins; D006801:Humans; D007223:Infant; D008297:Male; D009996:Osmotic Fragility; D012805:Sickle Cell Trait / Q000150:complications / Q000235:genetics*; D013103:Spherocytosis, Hereditary / Q000150:complications*; D013154:Spleen / Q000473:pathology / Q000503:physiopathology
D006454:Hemoglobins