Lymphoid subpopulations of peripheral blood and spleen in untreated Hodgkin's disease.
A panel of monoclonal antibodies with well-defined specificities were used as probes to investigate the phenotypes and lineage of circulating lymphoid cells and splenocytes in untreated patients with Hodgkin's disease. A significant relative and absolute reduction in T cells (anti-T3+) was found only in patients with B-symptoms. There was no alteration in the fraction of helper (anti-T4+) or cytotoxic/suppressor (anti-T5+) T cells circulating in peripheral blood when compared to normals, nor was there activation of these cells as measured by the development of surface Ia (anti-I1+). Circulating T cell subsets were not altered 5 to 14 days after splenectomy. Splenic T cells were increased equally in involved and uninvolved spleen when compared with control spleens obtained from accident victims. These findings indicate that abnormal T cell function in Hodgkin's disease may be the result of subtle alterations in T cells or non-T immunoregulatory mechanisms.
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology; D002648:Child; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006689:Hodgkin Disease / Q000276:immunology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013156:Splenectomy; D013601:T-Lymphocytes / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology
D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II