[Concentrations of mezlocillin in cerebrospinal fluid in vira meningitis (author's transl)].
The concentrations of mezlocillin in the cerebrospinal fluid were measured in ten patients with viral meningitis after a single infusion of 5 g lasting 30 minutes. One to two hours after infusion the CSF concentrations were between 0.1 mcg/ml and 1.6 mcg/ml, and thus exceeded the minimal inhibitory concentrations of Neisseria meningitidis and Diplococcus pneumoniae, the most common pathogens in bacterial meningitis in adults. The minimal inhibitory concentration of ampicillin-sensitive strains of Haemophilus influenzae was also attained. Further investigations must be carried out, in order to ascertain whether higher CSF concentrations are attained in bacterial meningitis.
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008587:Meningitis, Viral / Q000134:cerebrospinal fluid*; D008802:Mezlocillin; D008875:Middle Aged; D010406:Penicillins / Q000008:administration & dosage / Q000097:blood / Q000134:cerebrospinal fluid*
D010406:Penicillins; D008802:Mezlocillin
Mezlocillinkonzentration im Liquor bei Virusmeningitis.