Experiences with unexpected structural chromosome aberrations in prenatal diagnosis in a Danish series.
The investigation of 5547 prenatal diagnoses showed 31 unexpected structural chromosome rearrangements. These included 3 Robertsonian translocations, 14 reciprocal translocations and 14 inversions. All were balanced, including 5 de novo rearrangements. In 3 of these cases an induced abortion was performed and in 2 cases children without detectable malformations were delivered.
D000328:Adult; D002869:Chromosome Aberrations; D007446:Chromosome Inversion; D003718:Denmark; D005260:Female; D006801:Humans; D008423:Maternal Age; D010331:Paternal Age; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014178:Translocation, Genetic