Regeneration of retinal pigment epithelium damaged in rat foetuses by 6-aminonicotinamide.
The pathological changes induced by 6-AN (administered i. p. on day 15 of pregnancy) in the pigment epithelium of the retina were studied on days 17, 18, 19 and 20 of pregnancy by light and electronmicroscopy. The marked vacuolar degeneration (enlargement of the perinuclear cisterns) observed until day 18 of pregnancy is followed on days 19 and 20 by a practically total regeneration, by the restitution of the normal microscopic and submicroscopic feature. Within the eye, the regenerative phenomena mentioned are limited to the pigment epithelium (although initially similar pathological changes are observed also in its other components.
D015120:6-Aminonicotinamide / Q000009:adverse effects*; D000818:Animals; D005333:Fetus / Q000187:drug effects*; D009536:Niacinamide / Q000031:analogs & derivatives*; D010857:Pigment Epithelium of Eye / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D012038:Regeneration; D012160:Retina / Q000187:drug effects* / Q000196:embryology
D009536:Niacinamide; D015120:6-Aminonicotinamide