Se-Aryl selenenylthiosulphates and S-aryl sulphenylthiosulphates as thiol-blocking reagents.
Se-Aryl selenenylthiosulphates and S-aryl sulphenylthiosulphates inhibit papain at pH 5.8 much more rapidly than do the corresponding Se-aryl selenosulphates and S-aryl thiosulphates, and also more rapidly than do Se-alkyl selenosulphates. Se-p-Nitrophenyl selenenylthiosulphate and S-p-nitrophenyl sulphenylthiosulphate inactivate papain most rapidly, but the inactivation is slowly and spontaneously reversible. Inactivation by Se-o-nitrophenyl selenenylthiosulphate and S-o-nitrophenyl sulphenylthiosulphate, although less rapid than that by the para isomers, is essentially irreversible.
D055598:Chemical Phenomena; D002621:Chemistry; D005033:Ethylmaleimide / Q000494:pharmacology; D007700:Kinetics; D009578:Nitrobenzenes / Q000494:pharmacology*; D010206:Papain / Q000037:antagonists & inhibitors*; D012643:Selenium / Q000494:pharmacology*; D013434:Sulfenic Acids / Q000494:pharmacology*; D013439:Sulfhydryl Reagents / Q000494:pharmacology*; D013885:Thiosulfates / Q000494:pharmacology*
D009578:Nitrobenzenes; D013434:Sulfenic Acids; D013439:Sulfhydryl Reagents; D013885:Thiosulfates; D010206:Papain; D012643:Selenium; D005033:Ethylmaleimide