Effect of tricyclic antidepressant drugs on lymphocyte membrane structure.
Tricyclic antidepressant-induced perturbations of murine splenic lymphocyte membranes and cell surface concanavalin A receptor mobility have been investigated using the fluorescent probes diphenylhexatriene and fluorescein-conjugated concanavalin A. Results of these studies illustrate the possible relationship between tricyclic antidepressant-induced membrane perturbations and tricyclic antidepressant-induced suppression of the normal murine lymphocyte mitogen response. Tricyclic antidepressant effects on murine splenic lymphocyte membranes are dose-, time- and temperature- dependent. Murine lymphocyte concanavalin A cell surface receptor mobility is not apparently altered by the tricyclic antidepressants.
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D002462:Cell Membrane / Q000187:drug effects; D002478:Cells, Cultured; D003891:Desipramine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005456:Fluorescent Dyes; D007099:Imipramine / Q000494:pharmacology; D008214:Lymphocytes / Q000648:ultrastructure*; D008297:Male; D051379:Mice; D009661:Nortriptyline / Q000494:pharmacology; D011530:Protriptyline / Q000494:pharmacology; D013154:Spleen / Q000166:cytology; D013696:Temperature; D013997:Time Factors
D000929:Antidepressive Agents, Tricyclic; D005456:Fluorescent Dyes; D011530:Protriptyline; D009661:Nortriptyline; D007099:Imipramine; D003891:Desipramine