[Further study of the antiepileptic properties of nicotinamide].
Acute experiments on cats have shown that nicotinamide (100-500 mg/kg) injected intravenously suppresses the epileptic activity in solitary foci produced in the cortex by application for several seconds of a 0.5% solution of penicillin as well as in the complex of foci produced by application of a 0.1--3% solution of strychnine to various cortical zones. Nicotinamide (500-100 mg/kg) does not affect the character of the epileptic activity of foci created by application of 1% penicillin to the cerebral cortex or on the generalized epileptic activity produced by application of concentrated solutions of strychnine or penicillin. In an epileptic focus produced by application of 5-10% acetylcholine and 0.5% proserine, injection of nicotinamide leads at first to the disappearance of after-effect discharge and then of spike potential. It is concluded that nicotinamide has an antiepileptic activity.
D015097:3-Mercaptopropionic Acid / Q000037:antagonists & inhibitors; D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000818:Animals; D000927:Anticonvulsants; D001921:Brain / Q000378:metabolism; D002415:Cats; D009388:Neostigmine / Q000037:antagonists & inhibitors; D009536:Niacinamide / Q000627:therapeutic use*; D010406:Penicillins / Q000037:antagonists & inhibitors; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D013331:Strychnine / Q000037:antagonists & inhibitors; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000927:Anticonvulsants; D010406:Penicillins; D009536:Niacinamide; D009388:Neostigmine; D005680:gamma-Aminobutyric Acid; D015097:3-Mercaptopropionic Acid; D013331:Strychnine; D000109:Acetylcholine
Dal'neĭshee izuchenie protivoépilepticheskikh svoĭstv nikotinamida.