The effect of cyproterone acetate on the mouse adenohypophysis. II. Gonadotrophs and somatotrophs.
The adenohypophyses of adult male C57BL/6J mice pituitaries injected with cyproterone acetate for four weeks were examined with the electron microscope. The gonadotrophs showed an accumulation of the hormone-containing granules, and a noticeable decrease in the amount of rough endoplasmic reticulum. The somatotrophs exhibited proliferated profiles of rough endoplasmic reticulum, hypertrophied Golgi apparatus, and a slight decrease in the GH-containing granules. It is believed that the cyproterone acetate may have inhibited synthesis and release of the gonadotropins, and may have stimulated the GH -producing cells through the progestational activity of this antiandrogen.
D000818:Animals; D003272:Contraceptive Agents, Male / Q000494:pharmacology*; D003534:Cyproterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D017373:Cyproterone Acetate; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008854:Microscopy, Electron; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000648:ultrastructure*
D003272:Contraceptive Agents, Male; D017373:Cyproterone Acetate; D003534:Cyproterone