Incorporation of cis-octadecenoic acids into the rat liver mitochondrial membrane phospholipids and adipose tissue triglycerides.
The incorporation of the dietary cis 18:1(n-12) and cis 18:1(n-10) into liver mitochondrial membrane phospholipids and adipose tissue triglycerides was studied in 4 groups of rats fed diets containing 10 weight percent (wt %) of fat with the following contents of octadecenoic acids: 50% cis 18:1(n-12) + 9% cis 18:1(n-9); 25% cis 18:1(n-12) + 32% cis 18:1(n-9); 50% cis 18:1(n-10) + 10% cis 18:1(n-9); or 54% cis 18:1(n-9). Dietary linoleic acid was 3 wt % in all 4 groups. In the mitochondrial membranes, the isomeric octadecenoic acids were primarily incorporated into the 1-position of phosphatidylcholines and phosphatidylethanolamines at the expense of saturated fatty acids. The maximal incorporations observed in the 1-position of phosphatidylethanolamines were 4.8% 18:1(n-12) and 8.9% 18:1(n-10). No effects on the contents of polyunsaturated fatty acids in the phospholipids were seen. In the adipose tissue, the isomeric octadecenoic acids were incorporated at a level of 13% cis 18:1(n-12) or 23% cis 18:1(n-10), paralleled by a reduction in the content of oleic acid.
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage; D005227:Fatty Acids / Q000378:metabolism; D007425:Intracellular Membranes / Q000378:metabolism; D007536:Isomerism; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D009829:Oleic Acids / Q000378:metabolism*; D010743:Phospholipids / Q000096:biosynthesis*; D051381:Rats; D013047:Specific Pathogen-Free Organisms; D014280:Triglycerides / Q000096:biosynthesis*
D004041:Dietary Fats; D005227:Fatty Acids; D009829:Oleic Acids; D010743:Phospholipids; D014280:Triglycerides; C030245:8-octadecenoic acid; C008820:petroselinic acid