Screening for acidic and neutral drugs by high performance liquid chromatography in post-mortem blood.
A procedure for screening acidic and neutral drugs in post-mortem blood is presented. The procedure, which is sensitive and specific, employs high performance liquid chromatography with a reversed-phase column and an ultraviolet detector. The volume of specimen used is 1 mL. Over 40 drugs are identifiable by this technique, including analgesics, anti-inflammatory agents, barbiturates and other hypnotic-sedatives, and anti-epileptic drugs. To date, over 500 post-mortem blood specimens have been analyzed by the authors.
D000893:Anti-Inflammatory Agents / Q000097:blood; D000927:Anticonvulsants / Q000097:blood; D001463:Barbiturates / Q000097:blood; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D006863:Hydrogen-Ion Concentration; D004364:Pharmaceutical Preparations / Q000097:blood*; D011180:Postmortem Changes; D012997:Solvents
D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D001463:Barbiturates; D004364:Pharmaceutical Preparations; D012997:Solvents