[Effect of lipid peroxidation on DNA synthesis in Ehrlich ascites carcinoma cells].
The effect of lipid peroxidation (LPO) induced by Fe2+ and linoleic acid hydroperoxides in intact cells on the rate of DNA synthesis was investigated. It was found that intensification of LPO is accompanied by a decrease of DNA synthesis rate. Under effects of linoleic acid hydroperoxides, the repression of DNA synthesis is enhanced.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D007501:Iron / Q000378:metabolism; D008041:Linoleic Acids / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice
D004273:DNA, Neoplasm; D008041:Linoleic Acids; D008054:Lipid Peroxides; C008285:linoleic acid hydroperoxide; D008315:Malondialdehyde; D007501:Iron
Vliianie perekisnogo okisleniia lipidov na sintez DNK v kletkakh astsitnoĭ kartsinomy Erlikha.