[Routes of protein transport into the lungs from the bronchial vascular system].
In order to study the role of the bronchial vascular system in pulmonary protein transport, experiments have been performed in 6 anesthesized dogs, 16 isolated canine lungs and 10 white rats. When bilateral ligation of the bronchial arteries is performed in the anesthesized dogs, cessation of the bronchial blood stream results in decreasing protein transport and lymph outflow from the lungs. In the isolated canine lungs perfused through the pulmonary and bronchial vessels, lymph formation is determined by presence of the bronchial perfusion. As demonstrated the electron microscopical investigations with the marker of the protein transport--horseradish peroxidase--for 15 min of observation the marker does not get out of the limits of endothelium in the pulmonary capillaries. During this time horseradish peroxidase gets out of the bronchial vessels into the loose connective tissue of the lung, the lymphatic capillaries and the alveolar epithelium. Therefore, it is possible to make a conclusion on a predominated role of the protein transport in the lungs out of the bronchial vascular system as compared to the pulmonary system.
D000818:Animals; D001692:Biological Transport; D001798:Blood Proteins / Q000378:metabolism*; D001980:Bronchi / Q000098:blood supply*; D002196:Capillaries / Q000648:ultrastructure; D002199:Capillary Permeability; D004285:Dogs; D008168:Lung / Q000378:metabolism*; D008208:Lymphatic System / Q000378:metabolism*; D008264:Macrophages / Q000378:metabolism; D008854:Microscopy, Electron; D011650:Pulmonary Alveoli / Q000378:metabolism; D051381:Rats
D001798:Blood Proteins
Puti transporta belka v legkikh iz sistemy bronkhial'nykh sosudov.