[Chemotherapy of biliary tract infections (XXIV). Biliary excretion and gallbladder tissue levels of mezlocillin].
Mezlocillin (MZPC), a new broad spectrum penicillin, was studied for its biliary excretion and levels in gallbladder tissues. The mean serum concentration immediately after intravenous administration of 2 g of MZPC in 6 cholecystectomized patients was found to be 535.5 +/- 43.5 micrograms/ml, while its concentration in their gallbladder bile was 1,500-6,500 micrograms/ml at 30 minutes-1.5 hours and its concentration in their common duct bile was 6,500 and 4,000 micrograms/ml at 2 hours and 2.5 hours, respectively. Besides, its gallbladder tissue level around 2 hours was 37.5-500 micrograms/g, averaging as high as 215.6 +/- 79.5 micrograms/g. Crossover method was made to compare the biliary excretion of MZPC and PIPC in 4 patients inserted with a T-tube in their common bile duct. Each patient received 2 g each of 2 antibiotics intravenously. In case 1 with normal liver function, both drugs revealed the peak concentration of 3,500 micrograms/ml or more. In case 2, the peak concentration was 3,625 micrograms/ml for MZPC but 2,125 micrograms/ml for PIPC. In case 3 with slight hepatic dysfunction, the peak concentration for MZPC and PIPC was 906.4 micrograms/ml and 375.2 micrograms/ml, respectively. In case 4 with moderate hepatic dysfunction, the peak concentration for MZPC and PIPC was 27.6 micrograms/ml and 14.7 micrograms/ml, respectively. Simultaneous intravenous administration of MZPC and PIPC was made to compare the biliary excretion of these 2 antibiotics in 1 patient with T-tube drain in common bile duct. The bile concentration was measured by HPLC method which was developed by our laboratory.(ABSTRACT TRUNCATED AT 250 WORDS)
D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000378:metabolism; D001646:Bile / Q000378:metabolism*; D001660:Biliary Tract Diseases / Q000378:metabolism; D005260:Female; D005704:Gallbladder / Q000378:metabolism*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008802:Mezlocillin / Q000008:administration & dosage / Q000378:metabolism*; D008875:Middle Aged; D010878:Piperacillin / Q000008:administration & dosage / Q000378:metabolism
D008802:Mezlocillin; D010878:Piperacillin