Platelet monoamine uptake in relatives of patients with Huntington's chorea.
Uptake of dopamine and 5-hydroxytryptamine (5-HT) by the platelets of 25 symptom-free relatives of patients with established Huntington's chorea (HC) was not significantly different from that of control subjects. Platelet uptake of 5-HT in 3 subjects with early signs of the disease showed increased Km and Vmax values. Increased platelet uptake of 5-HT in patients with established HC was confirmed in a further 3 patients. It seems that this phenomenon appears with the clinical evidence of the disease. Further investigation of the nature of the platelet uptake abnormality may cast light on pathogenic factors in HC.
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D002648:Child; D004298:Dopamine / Q000097:blood*; D005260:Female; D006801:Humans; D006816:Huntington Disease / Q000097:blood / Q000175:diagnosis / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000097:blood*
D012701:Serotonin; D004298:Dopamine