Development of systemic lupus erythematosus after thymectomy for myasthenia gravis. Studies of suppressor cell function.
Systemic lupus erythematosus developed in an 18-year-old man three years after thymectomy for myasthenia gravis. The patient had considerable defects in suppressor cell function that seemed to be partially reversed in vitro by the addition of thymic hormone.
D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis; D006801:Humans; D007158:Immunologic Techniques; D066298:In Vitro Techniques; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D008297:Male; D009157:Myasthenia Gravis / Q000150:complications* / Q000276:immunology / Q000601:surgery; D011241:Prednisone / Q000627:therapeutic use; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology*; D013934:Thymectomy; D013951:Thymus Hormones / Q000494:pharmacology
D000974:Antibodies, Antinuclear; D013951:Thymus Hormones; D011241:Prednisone