'In situ' immune complex nephritis and basic proteins.
This investigation was designed to clarify the potential role of basic antigens in immune complex nephritis. The GBM is negatively charged and binds cationic substances. We studied 1) whether chemically cationised proteins can bind to the GBM, act as planted antigen, and induce 'in situ' immune complex formation or 2) if a pre-formed cationic antigen antibody complex can localise in the GBM. Results obtained with 5 chemically cationised proteins support the first possibility.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D001485:Basement Membrane / Q000378:metabolism; D002412:Cations; D005293:Ferritins / Q000378:metabolism; D006801:Humans; D007105:Immune Complex Diseases / Q000276:immunology*; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D007678:Kidney Glomerulus / Q000378:metabolism*; D009393:Nephritis / Q000276:immunology*; D010047:Ovalbumin / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism
D000936:Antigen-Antibody Complex; D002412:Cations; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011506:Proteins; D012709:Serum Albumin; D010047:Ovalbumin; D005293:Ferritins