Analysis of lipids and dioxin in chloracne due to tetrachloro-2,3,7,8-p-dibenzodioxin.
Biochemical investigations on the lipid and dioxin content of the cysts and comedo-like lesions of three children exposed to tetrachloro-2,3,7,8-p-dibenzodioxin (TCDD) have been performed. Gas chromatography and mass spectrometry failed to demonstrate the presence of dioxin despite the high sensitivity of the method. Further investigation by thin layer and gas chromatography-mass spectrometry showed that the lipids of the chloracne lesions in these children were exclusively epidermal in origin. These findings support the hypothesis that exposure to dioxin produces a hyperproliferative reaction of the cutaneous epithelium with squamous metaplasia of the cells lining the ducts of skin glands.
D000152:Acne Vulgaris / Q000139:chemically induced* / Q000378:metabolism; D002675:Child, Preschool; D002849:Chromatography, Gas; D004147:Dioxins / Q000032:analysis*; D005260:Female; D006801:Humans; D008055:Lipids / Q000032:analysis*; D008297:Male; D000072317:Polychlorinated Dibenzodioxins / Q000009:adverse effects
D004147:Dioxins; D008055:Lipids; D000072317:Polychlorinated Dibenzodioxins