Diuretics 1984.
Diuretics increase water excretion by inhibiting sodium transport in the nephron. They can be grouped according to their chemical class or (more practically) their site of action in the nephron. The site determines certain features of their effect, an important one being their effect on potassium excretion. Diuretics which act late in the nephron inhibit sodium transport in the region in which potassium is secreted, causing retention of potassium and hydrogen ions. These diuretics produce a hyperkalaemic acidosis; most others cause loss of potassium and hydrogen and a hypokalaemic alkalosis.
D000777:Anesthetics / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D004232:Diuretics / Q000009:adverse effects / Q000378:metabolism / Q000494:pharmacology*; D004347:Drug Interactions; D004487:Edema / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007700:Kinetics
D000777:Anesthetics; D000900:Anti-Bacterial Agents; D004232:Diuretics