Penicillinase-producing Neisseria gonorrhoeae.
Penicillinase-producing Neisseria gonorrhoeae (PPNG) causes the same clinical picture as nonpenicillinase-producing gonococci. Definitive identification depends on demonstration of penicillin resistance followed by tests for the beta-lactamase enzyme (penicillinase). Spectinomycin is the drug of choice but should be carefully reserved for laboratory-confirmed PPNG. Other drugs are effective. Over 2,000 cases have been reported since 1976, most originating in the Far East. Continuing spread is a certainty.
D003140:Communicable Disease Control; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy* / Q000453:epidemiology; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D009344:Neisseria gonorrhoeae / Q000201:enzymology*; D010402:Penicillin G Procaine / Q000627:therapeutic use; D010403:Penicillin Resistance; D010405:Penicillinase / Q000096:biosynthesis*; D010679:Philippines; D011339:Probenecid / Q000627:therapeutic use; D000198:Spectinomycin / Q000627:therapeutic use; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use; D014481:United States; D001618:beta-Lactamases / Q000096:biosynthesis*
D010402:Penicillin G Procaine; D000198:Spectinomycin; D014295:Trimethoprim; D010405:Penicillinase; D001618:beta-Lactamases; D013420:Sulfamethoxazole; D011339:Probenecid