[Heart rate behaviour and hemodynamics after oral therapy with ipratropium bromide in patients with sinus bradycardia (author's transl)].
Haemodynamic parameters were measured in 11 patients with sinus bradycardia before and 2.5, 4, 6 and 10 h following p.o. administration of 10 mg 8-isopropyl-3 alpha-DL-tropoyloxy-1 alpha H, 5 alpha H-tropanium hydroxide (ipratropium-bromide, Sch 1000). 2.5 h after Sch 1000 there was a significant rise in heart rate (p less than 0.001) which was still significantly elevated above control values 10 h following ipratropiumbromide ingestion (57.5 +/- 13.2 beats/min; p less than 0.001). Cardiac index was increased following ipratropiumbromide treatment and this was accompanied by a decrease in stroke volume.
D000368:Aged; D001286:Atropine Derivatives / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D001919:Bradycardia / Q000188:drug therapy*; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D009241:Ipratropium / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011651:Pulmonary Artery / Q000502:physiology; D013997:Time Factors
D001286:Atropine Derivatives; D009241:Ipratropium
Frequenzverhalten und Hämodynamik nach oraler Therapie mit Ipratropiumbromid bei Patienten mit Sinusbradykardie.