[Effect of cysteine hydrochloride and sulfate ion on morphological changes in the liver during chronic poisoning with yellow phosphorus].
It has been demonstrated that intragastric administration of cysteine hydrochloride in a dose of 50 mg/kg and sodium sulfate in a dose of 25 mg/kg with reference to sulfate ion reduced the circulatory disturbances, dystrophic and sclerotic changes in the rat liver caused by intragastric administration of yellow phosphorus in a dose of 1 mg/kg. Administration of the drugs interfered with the development of liver cirrhosis, stimulated regeneration, raised the adaptive abilities of hepatocytes. Cysteine protected hepatocyte mitochondria from phosphorus and activated their function. Meanwhile sulfate ion favoured glycogen accumulation in the cytoplasm of hepatocytes; cysteine hydrochloride and sulfate ion increased the content of total protein and glycogen in the liver and exerted an activating and normalizing effect on the enzymes of fatty, and carbohydrate metabolism, oxidative and energy processes.
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology* / Q000517:prevention & control; D003545:Cysteine / Q000627:therapeutic use*; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D010758:Phosphorus / Q000506:poisoning*; D051381:Rats; D013431:Sulfates / Q000627:therapeutic use*; D013997:Time Factors
D013431:Sulfates; D010758:Phosphorus; D003545:Cysteine
Vliianie solianokislogo tsisteina i sul'fat-iona na morfologicheskie izmeneniia v pecheni pri khronicheskoĭ intoksikatsii zheltym fosforom.