Acentric craniofacial cleft in a newborn female prenatally exposed to a high dose of diazepam.
A newborn female with craniofacial clefts, including cleft lip and palate, was studied. The mother had ingested 580 mg of diazepam in a single dose at about the 43rd day of gestation. The synchronism of the drug intake and the embryological development of the affected structures suggests an etiopathogenic relationship.
D000014:Abnormalities, Drug-Induced / Q000473:pathology*; D003975:Diazepam / Q000506:poisoning*; D005145:Face / Q000002:abnormalities* / Q000473:pathology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012886:Skull / Q000002:abnormalities* / Q000473:pathology
D003975:Diazepam