title: [Determination of bacterial endotoxin admixtures in inactivated influenza vaccines].
abstract: The materials substantiating the possibility of using the method for the determination of the lethal effect of endotoxin on dactinomycin-treated mice are presented. This determination is made with a view to detecting the admixtures of endotoxins in whole-virion and subvirion inactivated influenza vaccines at different stages of their manufacture, as well as in the final product. The proposed test is highly sensitive, rather simple in its practical realization and can be used for evaluating the degree of the purification of influenza vaccines from endotoxins.
mesh_terms: D000818:Animals; D003609:Dactinomycin / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000032:analysis* / Q000633:toxicity; D007252:Influenza Vaccines / Q000032:analysis* / Q000633:toxicity; D008722:Methods; D051379:Mice; D011786:Quality Control; D012485:Salmonella typhi; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000032:analysis / Q000633:toxicity
chemical_list: D004731:Endotoxins; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated; D003609:Dactinomycin
vernacular_title: Opredelenie primeseĭ bakterial'nykh éndotoksinov v inaktivirovannykh grippoznykh vaktsinakh.