[Effect of hydrocortisone on the liver cytochrome P-450 system and the intensity of food anaphylaxis in guinea pigs].
Intraperitoneal injection of hydrocortisone in single daily doses from 0.1 to 25.0 mg/kg, for 3 days was followed by reduced activity of liver microsomal monooxygenases and decreased content of cytochrome P-450 and b5. Hydrocortisone diminished the activity of the liver cytochrome P-450 system in vivo that significantly potentiated hexenal sleep. The hydrocortisone-inhibited activity of the liver chromosome P-450 system was followed by intensified food anaphylaxis in guinea-pigs.
D000707:Anaphylaxis / Q000276:immunology*; D000818:Animals; D065607:Cytochrome P-450 Enzyme Inhibitors; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004527:Egg Proteins / Q000276:immunology; D005512:Food Hypersensitivity / Q000276:immunology*; D006168:Guinea Pigs; D006591:Hexobarbital / Q000494:pharmacology; D006854:Hydrocortisone / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D012890:Sleep / Q000187:drug effects
D065607:Cytochrome P-450 Enzyme Inhibitors; D004527:Egg Proteins; D006591:Hexobarbital; D006854:Hydrocortisone
Vliianie gidrokortizona na sistemu tsitokhroma P-450 pecheni i vyrazhennost' pishchevoĭ anafilaksii u morskikh svinok.