Applicability of biosuppressin as an urease-inhibitor.
Prevention of the formation of struvite and carbonate-apatite calculi, which rapidly increase in size and tend to recur, is of prime importance. One of the urease inhibitors, hydroxycarbamide, was studied in vitro. The results are favourable and justify further studies aimed at the local application of the inhibitor.
D000641:Ammonia / Q000652:urine; D001031:Apatites / Q000652:urine; D001437:Bacteriuria / Q000517:prevention & control*; D002254:Carbonates / Q000652:urine; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006918:Hydroxyurea / Q000627:therapeutic use*; D007669:Kidney Calculi / Q000517:prevention & control*; D008274:Magnesium / Q000652:urine; D017616:Magnesium Compounds; D010710:Phosphates / Q000652:urine; D011512:Proteus Infections / Q000517:prevention & control*; D000069877:Struvite; D014510:Urease / Q000037:antagonists & inhibitors*
D001031:Apatites; D002254:Carbonates; D017616:Magnesium Compounds; D010710:Phosphates; D000641:Ammonia; D000069877:Struvite; D014510:Urease; D008274:Magnesium; D006918:Hydroxyurea