title: Tumor vascularization, hypoxia, staging of tumors and radiocurability.
abstract: Retrospective, morphometric analysis of histological preparations from cervical cancers indicate that the stromal component of the neoplastic tissue is richer in vascular elements in the cases in which the patients have a prolonged survival after radiotherapy. The finding supports earlier observations which indicate a relationship between intercapillary distance and radiocurability of cervical cancers. The routine determination of a vascularity index V, denoting the grade of vascular density in the neoplastic tissue, is suggested as a complementary parameter for the classification of tumours. Access to such an index could promote a more individualized tumor therapy, especially in regard to the control of radioresistant, hypoxic cells.
mesh_terms: D005260:Female; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology*; D009367:Neoplasm Staging; D009369:Neoplasms / Q000098:blood supply* / Q000473:pathology / Q000532:radiotherapy; D011836:Radiation Tolerance; D002583:Uterine Cervical Neoplasms / Q000098:blood supply / Q000532:radiotherapy