An electrophysiological study of 2-hexanone and 2,5-hexanedione neurotoxicity in rats.
n-Hexane and its metabolites are neurotoxic to animals and man. Studies have revealed a progressive neuropathy which affects the distal regions of motor and sensory peripheral nerves. This paper describes efforts to determine whether 2-hexanone or 2,5-hexanedione is more neurotoxic than 2-hexanone and that it first affects the distal axon. Concentrations of 20 mM produced no effects after 3 weeks but 40 mM increased distal latency after 2 weeks.
D000284:Administration, Oral; D000818:Animals; D001369:Axons / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004594:Electrophysiology; D006588:Hexanones / Q000008:administration & dosage / Q000633:toxicity*; D007659:Ketones / Q000633:toxicity*; D008297:Male; D008742:Methyl n-Butyl Ketone / Q000008:administration & dosage / Q000633:toxicity*; D010525:Peripheral Nerves / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D006588:Hexanones; D007659:Ketones; D008742:Methyl n-Butyl Ketone; C011269:2,5-hexanedione