Peroxidation of the dried thin film of lipid by high-energy alpha particles from a cyclotron.
High-energy alpha particles produced a dose-dependent linear increase in different lipid peroxidation products (e.g., malondialdehyde (MDA), conjugated dienes, and hydroperoxides) in the dried thin film state. An inverse dose-rate effect was observed when the dose rate was varied by changing either the alpha-particle fluence rate or the alpha-particle energy. The antioxidants alpha-tocopherol and butylated hydroxytoluene (BHT) suppressed the alpha-particle-induced lipid peroxidation in the dried thin film state, and in this respect alpha-tocopherol was found superior to BHT. It was found that alpha-tocopherol was equally efficient in inhibiting lipid peroxidations by alpha particles and ultraviolet light.
D000512:Alpha Particles; D000975:Antioxidants / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D008054:Lipid Peroxides; D008315:Malondialdehyde; D010315:Particle Accelerators; D010743:Phospholipids / Q000528:radiation effects*; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D008054:Lipid Peroxides; D010743:Phospholipids; D014810:Vitamin E; D002084:Butylated Hydroxytoluene; D008315:Malondialdehyde