A multivalent lacto-N-fucopentaose III-lysyllysine conjugate decompacts preimplantation mouse embryos, while the free oligosaccharide is ineffective.
A multivalent lacto-N-fucopentaose (LNFP) III-lysyllysine conjugate was observed to decompact preimplantation mouse embryos. Decompaction was not obtained with free oligosaccharides (LNFP II and III), nor with multivalent LNFP II-lysyllysine or chitotriose-lysyllysine conjugates. These results suggest a role for X hapten recognition during compaction and suggest further that X hapten valency may play a key role in modulating this developmental process.
D000818:Animals; D001755:Blastocyst / Q000187:drug effects / Q000502:physiology*; D002448:Cell Adhesion / Q000187:drug effects; D002450:Cell Communication / Q000187:drug effects; D004151:Dipeptides / Q000502:physiology*; D005314:Embryonic and Fetal Development / Q000187:drug effects; D005260:Female; D006241:Haptens / Q000502:physiology; D006801:Humans; D016256:Lewis X Antigen / Q000502:physiology*; D051379:Mice; D011247:Pregnancy
D004151:Dipeptides; D006241:Haptens; D016256:Lewis X Antigen; C024575:lysyllysine