title: Clonal origin of spontaneous multiple mammary tumors in mice with cellular mosaicism.
abstract: The clonal origin of spontaneous multiple mammary tumors in mice was examined. For this purpose, hybrid female mice (Pgk-1b/Pgk-1a), F1[SHN(Pgk-1b) X C3H/He (Pgk-1a)], with X-chromosome inactivation mosaicism with regard to the phosphoglycerate kinase (PGK)-1 isozyme together with a high incidence of spontaneous mammary tumors were constructed. Thirty-seven of 45 mammary tumors (82%) in mosaic mice had a single phenotype of PGK, indicating monoclonal origin. The multiple mammary tumors formed in these mice varied in PGK type, indicating independent cellular origins.
mesh_terms: D000818:Animals; D004303:Dosage Compensation, Genetic; D005260:Female; D008321:Mammary Glands, Animal; D051379:Mice; D008815:Mice, Inbred Strains; D009030:Mosaicism; D009369:Neoplasms / Q000201:enzymology / Q000209:etiology / Q000662:veterinary*; D010735:Phosphoglycerate Kinase / Q000032:analysis / Q000235:genetics; D012376:Rodent Diseases / Q000201:enzymology / Q000209:etiology*
chemical_list: D010735:Phosphoglycerate Kinase