Hypothalamic knife cuts attenuate maintenance of deoxycorticosterone acetate-salt induced hypertension.
These experiments tested the effects of knife cuts transecting neural pathways associated with the anteroventral third ventricle (AV3V) region on deoxycorticosterone acetate (DOCA)-salt induced hypertension. Coronal knife cuts of the descending medial neural pathway from the AV3V region between the medial preoptic area and anterior hypothalamus did not significantly alter DOCA-salt hypertension. However, parasagittal cuts which separated the AV3V region from the medial forebrain bundle attenuated the hypertension following 5 weeks of DOCA-salt treatment.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003900:Desoxycorticosterone / Q000494:pharmacology*; D006973:Hypertension / Q000503:physiopathology*; D007031:Hypothalamus / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains
D003900:Desoxycorticosterone