Effect of food on pharmacokinetics of chlorambucil and its main metabolite, phenylacetic acid mustard.
The influence of food intake on the pharmacokinetics of chlorambucil (C) and its cytotoxic metabolite, phenylacetic acid mustard (PAM), has been studied in man after oral doses of chlorambucil. The administration of chlorambucil with food resulted in slower absorption than when fasting. However, the area under the plasma concentration-time curve (AUC) was unaffected. The mean ratio AUCPAM/AUCC was 2.8 (range 1.4-7.1) under fasting and 3.3 (range 1.3-7.4) under nonfasting conditions. The metabolite very probably plays an important role in the cytotoxic effects observed after administration of C, since calculations show that a major fraction of the metabolite is eliminated by alkylation reactions.
D000328:Adult; D000368:Aged; D001711:Biotransformation; D002699:Chlorambucil / Q000378:metabolism*; D004435:Eating; D005260:Female; D006801:Humans; D007700:Kinetics; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009588:Nitrogen Mustard Compounds / Q000378:metabolism*; D013997:Time Factors
D009588:Nitrogen Mustard Compounds; C008826:phenacid; D002699:Chlorambucil