[Compounds with presumable antitumor activity. III. 1-Substituted N,N'-di-2-pyrimidinyl (or pyrazinyl)methylenediamine].
A series of 1-substituted N,N'-di-2-pyrimidinyl (or pyrazinyl)methylenediamines were synthesized as potential antitumor agents. The compounds were tested on lymphocytic murine leukemia P 388. The active 1-(2-chlorophenyl)-N,N'-(2-pyrazinyl)methylenediamine (IX) was also tested on other experimental tumors.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D003959:Diamines / Q000138:chemical synthesis / Q000494:pharmacology; D005260:Female; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D010051:Ovarian Neoplasms / Q000188:drug therapy; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000970:Antineoplastic Agents; D003959:Diamines; D011719:Pyrazines; D011743:Pyrimidines
Composti a presumibile attività antitumorale. Nota III. N,N'-di-2-pirimidinil (o pirazinil)metilendiamine-1-sostituite.