Behavioral recovery in albino rats with glutamate-damaged retinas.
Adult, male, albino rats were trained to discriminate between two patterned stimuli in a T-maze. Performance on this task was assessed following intravitreal injection of 1 mumol glutamate. Discrimination performance declined to nearly random levels by 1 day postinjection and remained significantly depressed for 2 weeks. However, by 2 months after injection, there was evidence of behavioral recovery to preinjection levels despite significant loss of inner retinal neurons. Task-related experience immediately following or 2 months after injection proved both necessary and facilitative for recovery.
D000818:Animals; D001522:Behavior, Animal; D005971:Glutamates / Q000633:toxicity*; D007267:Injections; D008297:Male; D010364:Pattern Recognition, Visual; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000187:drug effects*; D012162:Retinal Degeneration / Q000139:chemically induced / Q000503:physiopathology*; D012970:Sodium Glutamate / Q000008:administration & dosage / Q000633:toxicity*; D014785:Vision, Ocular; D014822:Vitreous Body
D005971:Glutamates; D012970:Sodium Glutamate