Syntheses of tetra- and pentapeptides from skin extracts of Phyllomedusa rhodei (tryptophyllins).
Syntheses by solution methods of tryptophyllins -4 and -5 (TPH-4 and TPH-5), tetra- and pentapeptides isolated from the skin extracts of the South American frog Phyllomedusa rhodei, are reported. The incorporation of the Pro2-Pro3 sequence into pentapeptides and the use of flash chromatography for purification of intermediates and target compounds are discussed. Preliminary biological results seem to indicate a growth-promoting activity for this peptide family.
D000595:Amino Acid Sequence; D000818:Animals; D001001:Anura; D004590:Electrophoresis, Paper; D007202:Indicators and Reagents; D009842:Oligopeptides / Q000138:chemical synthesis*; D012867:Skin / Q000032:analysis*; D012997:Solvents
D007202:Indicators and Reagents; D009842:Oligopeptides; D012997:Solvents