title: [Gametotoxic action of oxytetracycline on the early antenatal oogenesis of mice in in vivo and in vitro experiments].
abstract: Examination of the histological sections of mouse ovaries in the antenatal period following oxytetracycline treatment during proliferation of oogonia has shown the adequacy of some indicators obtained in experiments in vivo and in vitro (the index of sexual cells, the mitotic index of oogonia, the index of pathological mitoses of oogonia). The gametotoxic action of the drug manifested itself in a significant increase of the pathological mitoses of oogonia.
mesh_terms: D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D009866:Oogenesis / Q000187:drug effects*; D009867:Oogonia / Q000187:drug effects*; D010053:Ovary / Q000166:cytology / Q000187:drug effects; D010063:Ovum / Q000187:drug effects*; D010118:Oxytetracycline / Q000633:toxicity*; D011247:Pregnancy; D013997:Time Factors
chemical_list: D010118:Oxytetracycline
vernacular_title: Gametotoksicheskoe deĭstvie oksitetratsiklina na ranniĭ antenatal'nyĭ oogenez mysheĭ v éksperimentakh in vivo i in vitro.