Changes in calmodulin level after fertilization and during first cleavage in the egg of the urodelan amphibian Pleurodeles waltlii.
We report three significant calmodulin rises related to Pleurodeles waltlii egg fertilization and following developmental events. These elevations are correlated to the major obvious Ca2+-dependent events: Na+-H+ exchange, activation of NAD kinase, triggering of cortical reaction, resumption of meiotic division II, initiation of DNA synthesis and regulation of cell division. Therefore, it is suggested that alterations in calmodulin level in fertilized egg may be part of the Ca2+-dependent regulatory mechanisms which turn on metabolisms, initiate development and govern cell cleavages.
D000818:Animals; D001755:Blastocyst / Q000166:cytology / Q000502:physiology*; D002147:Calmodulin / Q000378:metabolism*; D004261:DNA Replication; D005260:Female; D005306:Fertilization; D007700:Kinetics; D009865:Oocytes / Q000166:cytology / Q000502:physiology*; D010999:Pleurodeles
D002147:Calmodulin