[Focal-segmental glomerulosclerosis in analgesic nephropathy].
The presence and extent of focal-segmental glomerulosclerosis/hyalinosis (FSSH) was determined in 79 autopsy cases of analgesic nephropathy and correlated with the levels of proteinuria, serum creatinine and arterial blood pressure. FSSH was present in 77% of cases. The extent of FSSH correlates positively with increasing proteinuria and serum creatinine. The widely scattered pattern suggests a multifactorial pathogenesis for FSSH in analgesic nephropathy, including, for example, glomerular overload and arterial hypertension. Mesangial proliferative glomerulonephritis was observed in only two cases.
D000328:Adult; D000368:Aged; D000700:Analgesics / Q000009:adverse effects*; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology*; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000150:complications; D008297:Male; D008875:Middle Aged
D000700:Analgesics
Fokal-segmentale Glomerulosklerose bei Analgetika-Nephropathie.