Hormonal control of fracture healing in a dog with chorea.
An experimental fracture in a dog with chorea was found to heal faster, and with a larger callus, than normal. Serum levels of parathormone (PTH), calcitonin (CT) and vitamin D metabolities were determined during callus formation. Serum concentrations of vitamin D metabolites were lower from the beginning while serum CT levels were higher compared to normal dogs. A massive increase in serum levels of 24,25-dihydroxyvitamin D was noted during the healing period. These results and observations suggest the existence of some disturbances in the secretion of hormones regulating calcium metabolism during bone repair where a nervous system lesion exists.
D000818:Animals; D002146:Bony Callus / Q000000981:diagnostic imaging; D002116:Calcitonin / Q000097:blood; D002118:Calcium / Q000378:metabolism; D002819:Chorea / Q000503:physiopathology*; D004100:Dihydroxycholecalciferols / Q000097:blood; D004285:Dogs; D050723:Fractures, Bone / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006728:Hormones / Q000502:physiology*; D008297:Male; D011859:Radiography; D014945:Wound Healing
D004100:Dihydroxycholecalciferols; D006728:Hormones; D002116:Calcitonin; D002118:Calcium