Chemical modification of tylosin. Thioether derivatives of tylosin and demycarosyltylosin.
Thioether derivatives of tylosin and demycarosyltylosin were synthesized by Michael-type addition of thiol to C-11 of the enone moiety on the aglycone. Some of tylosin derivatives were effective to macrolide resistant Staphylococcus aureus, and their in vivo activities were same or superior than that of tylosin.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D007933:Leucomycins / Q000138:chemical synthesis*; D015645:Tylosin / Q000031:analogs & derivatives
D000900:Anti-Bacterial Agents; D007933:Leucomycins; C032965:4'-dexydemycarosyltylosin; D015645:Tylosin