Intravenous extravasation injuries: the effectiveness of hyaluronidase in their treatment.
This experimental study in the rabbit establishes a reliable model for the production of skin necrosis analogous to intravenous extravasation injuries in humans. The effectiveness of hyaluronidase in reducing the extent of tissue injury is examined, using several different toxic agents.
D000818:Animals; D002122:Calcium Chloride / Q000009:adverse effects; D004317:Doxorubicin / Q000009:adverse effects; D005119:Extravasation of Diagnostic and Therapeutic Materials; D005526:Food, Formulated / Q000009:adverse effects; D006821:Hyaluronoglucosaminidase / Q000627:therapeutic use*; D009336:Necrosis; D011817:Rabbits; D012867:Skin / Q000187:drug effects* / Q000473:pathology; D013997:Time Factors
D004317:Doxorubicin; D006821:Hyaluronoglucosaminidase; D002122:Calcium Chloride