Nitrogen mustard (mechlorethamine) and UVB photocarcinogenesis: a dose response effect.
The effects of UVB energy and nitrogen mustard (mechlorethamine, HN2) on tumor formation in the hairless mouse skin was examined. Twice weekly applications of HN2 produced tumors in 34% of the mice. In addition, the HN2 treatments plus UVB radiation resulted in a significant acceleration in tumor formation as compared to either carcinogenic stimulus alone. The twice weekly application of HN2 plus UVB exposure was more tumorigenic than UVB plus HN2 applied once a week. Thus a positive carcinogenic dose response was noted. No tumor-suppressing effects were detected in this study.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000209:etiology*; D004305:Dose-Response Relationship, Drug; D008466:Mechlorethamine / Q000008:administration & dosage / Q000009:adverse effects*; D051379:Mice; D008812:Mice, Hairless; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000209:etiology*; D014466:Ultraviolet Rays / Q000009:adverse effects*
D008466:Mechlorethamine