title: [Extraction behavior of polypropylenes. 87. Problems in the use of plastic containers for fluid drugs].
abstract: Studies on the extraction of antioxidants in different polypropylene samples subjected to variable extraction terms proved that storing neutral or faintly acid infusion solutions or those with an ethanol content up to 10% for several months, the extracted antioxidants are in allowable ranges. Insignificantly increased amounts of antioxidants are delivered to alkaline solutions and to ethanol/water mixtures having increased ethanol contents. The methods and specified limiting values of the GDR pharmacopoeia have been consulted for the semiquantitative estimate of extractives.
mesh_terms: D000975:Antioxidants / Q000032:analysis; D002626:Chemistry, Pharmaceutical; D002855:Chromatography, Thin Layer; D004349:Drug Packaging; D004355:Drug Stability; D004364:Pharmaceutical Preparations / Q000032:analysis*; D010969:Plastics / Q000032:analysis*; D011126:Polypropylenes / Q000032:analysis*; D013242:Sterilization; D013696:Temperature
chemical_list: D000975:Antioxidants; D004364:Pharmaceutical Preparations; D010969:Plastics; D011126:Polypropylenes
vernacular_title: Extraktionsverhalten von Polypropylen. 87. Mitteilung: Zur Problematik des Einsatzes von Kunststoffbehältern für flüssige Arzneizubereitungen.