Prolonged cholestatic jaundice and leukopenia associated with piroxicam.
A case of prolonged cholestatic jaundice and leukopenia occurring in a 60 year old wh piroxicam--a non-steroidal antiinflammatory agent--is reported. Histological examination of liver biopsy revealed pronounced canalicular and intracellular bile retention. After discontinuation of the drug serum bilirubin declined to normal values over a period of 10 weeks.
D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000627:therapeutic use; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced*; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy; D010894:Piroxicam; D013843:Thiazines / Q000009:adverse effects* / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D013843:Thiazines; D010894:Piroxicam