Iron overload and lysosomal stability in beta zero-thalassaemia intermedia and trait: correlation between serum ferritin and serum N-acetyl-beta-D-glucosaminidase levels.
Increased iron storage represents a characteristic condition in patients with beta zero-thalassaemia intermedia. Iron overload is an important factor in cellular damage. Recent studies have shown an enhanced lysosomal fragility due to increased iron storage. 13 patients with beta-thalassaemia intermedia, aged 17-44 years, were studied. Both serum ferritin and serum N-acetyl-beta-D-glucosaminidase levels were evaluated in all subjects studied. A significant linear correlation (P less than 0.05) between serum ferritin and serum N-acetyl-beta-D-glucosaminidase levels were found.
D000118:Acetylglucosaminidase / Q000097:blood*; D000328:Adult; D005260:Female; D005293:Ferritins / Q000032:analysis*; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008247:Lysosomes / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D013789:Thalassemia / Q000097:blood*
D005293:Ferritins; D007501:Iron; D006596:Hexosaminidases; D000118:Acetylglucosaminidase