The reactivation by oximes of phosphonylated acetylcholinesterase: the possible erroneous interpretation of reactivating potency.
A comparative study of the reactivation by two oximes of acetylcholinesterase inhibited by several organophosphates has been made, with particular reference to the dependence of the degree of reactivation produced by an oxime (reactivating potency) upon the concentration of inhibited enzyme. In the case of one inhibitor it is demonstrated that the relative reactivating potency of the two oximes can be reversed by a change in experimental conditions. It is concluded that the measurement of the reactivation produced by two or more oximes, particularly when carried out under standardized conditions, is of little value in determining their relative reactivating potencies, and of negligible value in predicting their likely therapeutic effectiveness against organophosphate poisoning.
D000110:Acetylcholinesterase / Q000032:analysis*; D002800:Cholinesterase Inhibitors; D009946:Organothiophosphorus Compounds / Q000494:pharmacology; D010091:Oximes / Q000494:pharmacology*; D012524:Sarin / Q000494:pharmacology; D012999:Soman / Q000494:pharmacology
D000110:Acetylcholinesterase; D002800:Cholinesterase Inhibitors; D009946:Organothiophosphorus Compounds; D010091:Oximes; D012524:Sarin; D012999:Soman; C009680:VX-agent