title: Failure of mexiletine to relieve severe pruritus.
abstract: Mexiletine, an antiarrhythmic drug with pharmacological properties similar to lidocaine, was tested for antipruritic effect in 4 patients with severe pruritus. Although the plasma levels were within the therapeutic range for antiarrhythmic effects, a consistent relief of pruritus could not be found.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008801:Mexiletine / Q000097:blood / Q000627:therapeutic use*; D011437:Propylamines / Q000627:therapeutic use*; D011537:Pruritus / Q000097:blood / Q000188:drug therapy*
chemical_list: D011437:Propylamines; D008801:Mexiletine