Ethanol diminishes the toxicity of the mushroom Amanita phalloides.
Survival of mice after lethal doses of a lyophilizate from Amanita phalloides ('death cap') was markedly increased by single doses of ethanol applied 30 min before or 5 min after the mushroom. Hepatic histopathological damage (confluent necrosis) was largely prevented. Acute, but not chronic, consumption of ethanol may thus influence favorably the outcome of death cap poisoning and should be taken into consideration in the evaluation of therapeutic measures.
D000545:Amanita; D000546:Amanitins / Q000633:toxicity; D000818:Animals; D004347:Drug Interactions; D000431:Ethanol / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D008099:Liver / Q000473:pathology; D051379:Mice; D009145:Mushroom Poisoning / Q000188:drug therapy* / Q000473:pathology; D009183:Mycotoxins / Q000633:toxicity*; D010590:Phalloidine / Q000633:toxicity
D000546:Amanitins; D009183:Mycotoxins; D010590:Phalloidine; D000431:Ethanol