[Effect of interferon on cell cycle phases in cultured human tumor cells].
The action of homological and heterological (pig) leukocytic interferon on cell cycle kinetics of cultivated human tumour cells (lines HeLa, CaOv) and diploid strain was studied by flow cytofluorimetry. The cells of HeLa line and dFch strain demonstrated low sensitivity to interferon administration. The cells of interferon-sensitive line CaOv reacted by the change in cell cycle kinetics (arrest in G2/M). The action of heterological interferon on sensitive cells was similar to that of homological one.
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005347:Fibroblasts / Q000166:cytology; D006367:HeLa Cells; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D009369:Neoplasms / Q000473:pathology*; D013552:Swine
D007370:Interferon Type I
Deĭstvie interferona na raspredelenie po fazam kletochnogo tsikla kul'tiviruemykh opukholevykh kletok cheloveka.