[The effect of dietary lipids on microsomal electron transport proteins in the rat].
Feeding a fat-free diet for 3 weeks decreases the activity of ascorbate:ferricytochrome b5 oxidoreductase and increases NADH:monodehydroascorbate oxidoreductase in rat liver microsomes. Contrary to Vmax, the apparent Km for monodehydroascorbate of the first enzyme was not depressed. The activity of ascorbate:ferricytochrome b5 oxidoreductase is increased by incubation with microsomal lipid extract, thus showing that the loss of activity results from dietary-induced changes of microsomal fatty acid composition.
D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D004041:Dietary Fats / Q000494:pharmacology*; D004579:Electron Transport / Q000187:drug effects; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D002352:Carrier Proteins; D004041:Dietary Fats; D009243:NAD; D010088:Oxidoreductases; C019739:L-ascorbate--cytochrome-b5 reductase
Wirkung von Nahrungslipiden auf mikrosomale Elektronentransportproteine der Ratte.