Potential mutagenic activity of some vitamin preparations in the human gut.
Rutin is a nonmutagenic flavonol glycoside, whereas its aglycone quercetin is mutagenic. Cell-free preparations from fecal cultures (fecal preparations) contain a beta-glucosidase that, when incubated with rutin, hydrolyzes it to quercetin. This activity can be further induced when rutin is added to the fecal culture from which the cell-free preparation is made. When vitamin pills that contain rutin are added to the cultures, this induction is equally effective. The vitamin extracts by themselves, like rutin, were nonmutagenic; however, when the vitamin extracts were incubated with fecal preparations containing induced beta-glucosidase, a great increase in mutagenicity was observed.
D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D009153:Mutagens / Q000378:metabolism*; D012431:Rutin / Q000378:metabolism*; D014815:Vitamins / Q000009:adverse effects*
D009153:Mutagens; D014815:Vitamins; D012431:Rutin