Misonidazole neurotoxicity in rats: Part II. Effect of pre- and intermittent treatment with pentobarbital on misonidazole neurotoxicity in the rat.
Rats pretreated for 5 days with 50 mg/kg of pentobarbital tolerated statistically significant higher doses of misonidazole before the onset of misonidazole-induced neurotoxicity than rats treated intermittently with the same dose of pentobarbital. Presumably in pretreated rats, pentobarbital induced an increase in the activities of hepatic microsomal enzymes that led to a more rapid metabolism of misonidazole than in rats treated only intermittently.
D000818:Animals; D004790:Enzyme Induction; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology / Q000378:metabolism; D008920:Misonidazole / Q000037:antagonists & inhibitors* / Q000378:metabolism; D009593:Nitroimidazoles / Q000037:antagonists & inhibitors*; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009593:Nitroimidazoles; D008920:Misonidazole; D010424:Pentobarbital