Influence of DL-2-phenyl[6-ethoxybenzothiazolyl-(2)-thio]propionic acid (EMD 34853) on gallstone formation in hamsters.
The effects of two levels (50 and 167 mg/kg) of a new hypocholesterolemic drug (EMD 34853) on gallstone formation in hamsters were investigated. Lithogenicity was inhibited by 28-45%. Levels of biliary lipids (cholesterol, phospholipid, bile acids) were reduced in the drug-treated animals.
D000818:Animals; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D001647:Bile Acids and Salts / Q000378:metabolism; D002769:Cholelithiasis / Q000517:prevention & control*; D002784:Cholesterol / Q000378:metabolism; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D050356:Lipid Metabolism; D008297:Male; D008647:Mesocricetus; D013844:Thiazoles / Q000494:pharmacology*
D000924:Anticholesteremic Agents; D001647:Bile Acids and Salts; D013844:Thiazoles; C041008:tazasubrate; D002784:Cholesterol