title: Generation of slow-reacting substance (leukotrienes) by endotoxin and lipid A from human polymorphonuclear granulocytes.
abstract: Leukotrienes were released from human polymorphonuclear granulocytes on incubation with endotoxins and lipid A. The analysis was performed by their smooth muscle contracting properties, reversed phase high-pressure liquid chromatography and radioimmunoassay for leukotrienes C4 and D4. The active component of the lipopolysaccharides seems to be the lipid A portion.
mesh_terms: D001681:Biological Assay; D002851:Chromatography, High Pressure Liquid; D004731:Endotoxins / Q000494:pharmacology*; D006801:Humans; D008050:Lipid A / Q000494:pharmacology*; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism*; D013189:SRS-A / Q000032:analysis / Q000096:biosynthesis*; D012475:Salmonella
chemical_list: D004731:Endotoxins; D008050:Lipid A; D013189:SRS-A