Parathyroid hormone concentration in the serum of people with cadmium-induced renal damage.
Serum parathyroid hormone (PTH) and renal functions were measured in thirty subjects with cadmium-induced renal damage and in the same number of control subjects. The negative correlations between PTH and creatinine clearance (Ccr) and between PTH and percentage renal phosphorus reabsorption (% TRP) were significant in the cadmium (Cd)-exposed group. Serum PTH concentrations were clearly high in two cases of the cadmium-exposed group. Their renal functions decreased severely compared with those of the other Cd-exposed people. The present study indicates that chronic cadmium intoxication could cause increased secretions of PTH, which may be related to cadmium-induced bone damage.
D000368:Aged; D002105:Cadmium Poisoning / Q000097:blood* / Q000503:physiopathology; D003404:Creatinine / Q000378:metabolism*; D004781:Environmental Exposure; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007564:Japan; D007674:Kidney Diseases / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D007677:Kidney Function Tests; D007684:Kidney Tubules / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood*; D010758:Phosphorus / Q000378:metabolism
D010281:Parathyroid Hormone; D010758:Phosphorus; D003404:Creatinine