Low dose choline chloride in cerebellar degeneration.
Sixteen patients with cerebellar degeneration were treated with oral choline chloride for six weeks at doses of 3 and 6 g daily. Two patients improved with choline but another four improved with placebo. Choline chloride in a dose of 3-6 g daily is no better than placebo in improving ataxia due to cerebellar degeneration.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002524:Cerebellar Ataxia / Q000188:drug therapy; D002526:Cerebellar Diseases / Q000188:drug therapy*; D002794:Choline / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006261:Headache / Q000139:chemically induced; D006801:Humans; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration / Q000187:drug effects*; D013118:Spinal Cord Diseases / Q000188:drug therapy
D002794:Choline