[Inflammatory eye changes in the mouse caused by herpesvirus. Changes caused by the cytopathogenic effect. An animal model].
The reproducible inflammatory changes caused by infection with herpes simplex virus (Eidolon-Virus) in the anterior segment in mice represent a useful model. They are very similar to severe inflammation of the eye, as seen in herpes simplex infection. The method used by the authors to damage the corneal epithelium with a local anesthetic is similar to human pathology, in which a disturbance of the protective function of the corneal epithelium also facilitates infection by herpes simplex virus as well. The changes described are a starting point for further investigations.
D000818:Animals; D000867:Anterior Chamber / Q000473:pathology; D003315:Cornea / Q000473:pathology; D003588:Cytopathogenic Effect, Viral; D004195:Disease Models, Animal; D004848:Epithelium / Q000473:pathology; D005260:Female; D007635:Keratitis, Dendritic / Q000473:pathology*; D051379:Mice; D008855:Microscopy, Electron, Scanning; D014822:Vitreous Body / Q000473:pathology
Entzündliche Augenveränderungen bei der Maus durch das Herpes-Virus. Veränderungen durch den zytopathogenen Effekt. Ein Tiermodell.