title: Hoe 263, a new substance with calcium channel antagonistic activity.
abstract: Hoe 263 inhibited the contraction of the potassium-depolarized pulmonary artery of the guinea pig. In this experiment it was slightly more active than verapamil. The calcium uptake of the potassium-depolarized pulmonary artery was inhibited by Hoe 263 more effectively than by prenylamine. The upstroke velocity of the potassium-depolarized papillary muscle of the guinea pig was depressed with similar concentrations of Hoe 263 and verapamil. In the (3H)-nitrendipine binding test, Hoe 263 was effective at similar concentrations as prenylamine and verapamil. The positive inotropic effect of K-strophanthin was depressed by Hoe 263 at concentrations which were comparable with those necessary for verapamil.
mesh_terms: D000818:Animals; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D002121:Calcium Channel Blockers; D002132:Calcium Radioisotopes; D003529:Cymarine / Q000494:pharmacology; D004285:Dogs; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008566:Membranes / Q000378:metabolism; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D009467:Neuromuscular Depolarizing Agents; D009543:Nifedipine / Q000031:analogs & derivatives / Q000378:metabolism; D009568:Nitrendipine; D010210:Papillary Muscles / Q000378:metabolism; D011188:Potassium / Q000494:pharmacology; D011299:Prenylamine / Q000494:pharmacology; D011651:Pulmonary Artery / Q000187:drug effects
chemical_list: D001559:Benzhydryl Compounds; D002121:Calcium Channel Blockers; D002132:Calcium Radioisotopes; D009467:Neuromuscular Depolarizing Agents; C042939:N-(2-benzhydryloxy)ethyl-N-methyl-(1-ethyl-2-(3-methoxyphenyl)ethyl)amine; D009568:Nitrendipine; D009543:Nifedipine; D011299:Prenylamine; D011188:Potassium; D003529:Cymarine