title: [Changes in the histamine content and morphology of the gastric mucosa in duodenal ulcer after pentagastrin stimulation].
abstract: A parallel study on histamine concentration and morphology of biopsy from gastric mucosa, was carried out with 60 patients with duodenal ulcer, prior to and post stimulation with pentagastrin--6 micrograms/kg. Histamine was spectrofluorimetrically determined. The functional-morphological changes that developed were followed up on 15, 30 and 60 min after the stimulation. They were a functional character and were due to disturbed microcirculation of the gastric mucosa: edema, venous stasis and leukopedesis. The latter were progressively increased within the course of 1 hour after the stimulation. The histamine-mobilizing effect of pentagastrin was manifested with a short-term decrease, followed by a considerable increase of histamine content in gastric mucosa of the patients with duodenal ulcer.
mesh_terms: D001707:Biopsy, Needle; D004381:Duodenal Ulcer / Q000378:metabolism* / Q000473:pathology; D005753:Gastric Mucosa / Q000473:pathology*; D006632:Histamine / Q000032:analysis*; D006801:Humans; D010418:Pentagastrin; D013050:Spectrometry, Fluorescence
chemical_list: D006632:Histamine; D010418:Pentagastrin
vernacular_title: Promeni v khistaminovoto sŭdŭrzhanie i morfologiiata na stomashnata ligavitsa pri duodenalna iazva sled stimulatsiia s pentagastrin.