2',3'-Dideoxy-3'-aminonucleoside 5'-triphosphates inhibit the repair of DNA in rat liver chromatin.
2',3'-Dideoxy-3'-aminonucleoside 5'-triphosphates are shown to be strong inhibitors of repair DNA synthesis in gamma-irradiated rat liver chromatin. The activity of these compounds is comparable with that of the most effective inhibitor of the DNA polymerase beta-catalyzed repair DNA synthesis.
D000818:Animals; D002843:Chromatin / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects*; D004261:DNA Replication / Q000187:drug effects; D003854:Deoxyribonucleotides / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D051381:Rats; D013329:Structure-Activity Relationship
D002843:Chromatin; D003854:Deoxyribonucleotides