Support of cochlear metabolic and ion transport processes solely by perilymphatic perfusion.
Morphologic considerations would seem to suggest that the cochlear duct could not be maintained in a fully functional state in the absence of a blood supply. We found, however, that perilymphatic perfusion could be used as a substitute for the normal vascular circulation. The criteria used to determine cochlear function included (1) normal endocochlear potential, (2) normal net secretory flux of rubidium (as a tracer for K), and (3) normal levels of ATP in both the organ of Corti and the stria vascularis. All criteria were satisfied by our perfusion regimen.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D003051:Cochlea / Q000098:blood supply / Q000378:metabolism*; D005072:Evoked Potentials, Auditory; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007511:Ischemia / Q000628:therapy; D009925:Organ of Corti / Q000378:metabolism; D010477:Perfusion / Q000379:methods*; D012533:Scala Tympani / Q000378:metabolism; D013316:Stria Vascularis / Q000378:metabolism
D000255:Adenosine Triphosphate