Synthesis of 4-substituted aminoquinoline-3-carboxylates as potential antimicrobial agents.
A series of 4-substituted aminoquinoline-3-carboxylates was prepared and evaluated for antimicrobial activity. Four of the compounds (VIII, XIII, XV, and XXIII) exhibited low activity against Staphylococcus aureus.
D000634:Aminoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects*; D002264:Carboxylic Acids / Q000138:chemical synthesis / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006868:Hydrolysis; D008826:Microbial Sensitivity Tests
D000634:Aminoquinolines; D000900:Anti-Bacterial Agents; D002264:Carboxylic Acids