[Radiation injury of hemopoiesis in alpine conditions depending upon the duration of adaptation].
A study was made of the disturbance of haemopoiesis in the small laboratory animals and dogs kept in Alpine conditions (3200 m) and exposed to ionizing radiation on days 3, 15, 22, 25 and 33 of adaptation. The radiation damage to haemopoiesis in Alpine conditions was shown to decrease at the beginning of the adaptation due to the intensification of the regenerating processes, which was manifested by the increase in the rate of DNA synthesis in the haemopoietic organs, and activation of erythropoiesis, myelopoiesis and lymphopoiesis. Later (after 30-35 days), a 2-4-fold increase was noted in the number of haemopoietic stem cells which improved the compensatory potency of the tissue under study and increased the total resistance of the organism.
D000222:Adaptation, Physiological; D000531:Altitude; D000818:Animals; D003114:Colony-Forming Units Assay; D004307:Dose-Response Relationship, Radiation; D006410:Hematopoiesis / Q000528:radiation effects*; D006412:Hematopoietic Stem Cells / Q000528:radiation effects; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000503:physiopathology*; D051381:Rats; D013997:Time Factors
Luchevoe porazhenie gemopoéza v usloviiakh vysokogor'ia v zavisimosti ot dlitel'nosti adaptatsii.