Use of decline in D-xylose absorption to predict infection following intensive chemotherapy.
Oral D-xylose absorption and urinary excretion were measured before and after 32 courses of intensive chemotherapy in 14 patients with acute leukemia in complete remission. The incidence of severe and life-threatening infectious complications was greatest in those patients in whom the absorption and excretion of D-xylose fell below normal immediately following 4-7 days of chemotherapy. Gram-negative bacilli and staphylococci were the most common organisms to cause bacteremia in these patients.
D000208:Acute Disease; D000284:Administration, Oral; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D007408:Intestinal Absorption; D007938:Leukemia / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D018805:Sepsis / Q000150:complications / Q000175:diagnosis*; D014994:Xylose / Q000008:administration & dosage / Q000378:metabolism
D000970:Antineoplastic Agents; D014994:Xylose