title: High dose barbiturate therapy in neurosurgery and intensive care.
abstract: To assess the uses of high dose barbiturate therapy in neurosurgery and intensive care, the authors have undertaken a concise survey of relevant experimental investigations and a comprehensive review of published clinical experiences.
mesh_terms: D001463:Barbiturates / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects; D001927:Brain Diseases / Q000601:surgery*; D001929:Brain Edema / Q000188:drug therapy; D002545:Brain Ischemia / Q000188:drug therapy; D002560:Cerebrovascular Circulation / Q000187:drug effects; D003422:Critical Care / Q000379:methods*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D004734:Energy Metabolism / Q000187:drug effects; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects; D008054:Lipid Peroxides / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D010424:Pentobarbital / Q000627:therapeutic use; D010634:Phenobarbital / Q000627:therapeutic use; D013874:Thiopental / Q000627:therapeutic use
chemical_list: D001463:Barbiturates; D008054:Lipid Peroxides; D010424:Pentobarbital; D013874:Thiopental; D010634:Phenobarbital