Dose- and sex-independent disposition of ciprofloxacin.
Serum concentrations and urinary excretion of ciprofloxacin were studied in female and male volunteers following a single oral administration of 100 mg, 250 mg, 500 mg or 1000 mg. Serum and urine concentrations increased proportionally to the increasing dose administered but independently of sex. Twenty-five percent of the administered dose was excreted in the urine as unmetabolized ciprofloxacin within the first 24 hours after oral administration. Renal clearance averaged 5 ml/min X kg.
D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000097:blood*; D002939:Ciprofloxacin; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D011804:Quinolines / Q000008:administration & dosage / Q000097:blood*; D012737:Sex Factors
D000890:Anti-Infective Agents; D011804:Quinolines; D002939:Ciprofloxacin