A combination of cefuroxime and N-acetyl-cysteine for the treatment of maxillary sinusitis in children with respiratory allergy.
Twenty-four atopic children with allergic rhinitis, asthma and maxillary sinusitis were treated with a combination of cefuroxime 50-80 mg/kg/day and N-acetyl-cysteine 15-25 mg/kg/day administered intramuscularly for 10 days. The efficacy of the treatment was judged on the basis of radiological and clinical evolution. The treatment was effective in 95.8% of the children, and 37.5% of them were able to reduce their treatment for asthma. None of the patients suffered severe side effects. The data obtained confirm that appropriate treatment of the sinusitis frequently results in a significant improvement of the asthmatic condition.
D000111:Acetylcysteine / Q000627:therapeutic use*; D000293:Adolescent; D001249:Asthma / Q000150:complications / Q000628:therapy; D002444:Cefuroxime / Q000627:therapeutic use*; D002511:Cephalosporins / Q000627:therapeutic use*; D002648:Child; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D006801:Humans; D008443:Maxillary Sinus; D012130:Respiratory Hypersensitivity / Q000150:complications / Q000628:therapy*; D012852:Sinusitis / Q000150:complications / Q000188:drug therapy*
D002511:Cephalosporins; D002444:Cefuroxime; D000111:Acetylcysteine