Plasma EC-superoxide dismutase activity in insulin-dependent diabetic children.
Toxic oxygen-centered radicals have been linked to beta-cell damage brought about by some chemicals and might conceivably also be of importance in the pathogenesis of spontaneous insulin-dependent diabetes mellitus (IDDM). In several model systems, superoxide dismutase has been protective. The major protector against superoxide radicals in the extracellular space appears to be a recently discovered superoxide dismutase, EC-superoxide dismutase. This enzyme was analysed in plasma from children with insulin-dependent diabetes mellitus. The specimens were obtained from 8 patients with disease of recent onset and from 15 patients with disease of longer duration. There was no significant difference in EC-superoxide dismutase between the patients and controls.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000201:enzymology*; D005110:Extracellular Space / Q000201:enzymology; D005260:Female; D006801:Humans; D008297:Male; D013482:Superoxide Dismutase / Q000097:blood*
D013482:Superoxide Dismutase