title: Membrane invasion culture system (MICS).
abstract: New methods for studying the invasive properties of malignant neoplasms are being developed continually. The advantages and disadvantages associated with currently available models have been capitalized upon in the development of a new system that is versatile, reliable, fast, and simple to operate. In order for a tumor cell to metastasize, it must be capable of traversing many complex biological barriers. Because treatment metastatic neoplasms poses many problems for the clinician, the elucidation of the invasion process is of vital importance for the successful treatment of malignant disease. We have developed a system for studying the invasive properties of cells that can be performed accurately with relative ease within a short period of time. This versatile system offers extensive applications for studying invasion properties and parameters. Our model is classified as the Membrane Invasion Culture System.
mesh_terms: D000650:Amnion; D001485:Basement Membrane; D002460:Cell Line; D006801:Humans; D008545:Melanoma / Q000473:pathology; D008722:Methods; D009361:Neoplasm Invasiveness