Toxicity of intravitreal antiviral drugs.
Two systemic agents, vidarabine and acyclovir, were tested for ocular toxicity in intravitreal injection and vitrectomy infusion solutions. On the basis of this study we recommend using up to 30 mcg/0.1 ml of vidarabine as an intraocular injection or 8 to 16 mcg/ml in vitrectomy infusion fluid. For acyclovir, 80 mcg/0.1 ml as an intraocular injection or 40 mcg/ml in vitrectomy infusion fluid may be a therapeutic adjunct for managing viral retinitis.
D000212:Acyclovir / Q000008:administration & dosage / Q000633:toxicity*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005123:Eye / Q000187:drug effects* / Q000473:pathology; D007267:Injections; D011817:Rabbits; D014740:Vidarabine / Q000008:administration & dosage / Q000633:toxicity*; D014822:Vitreous Body
D014740:Vidarabine; D000212:Acyclovir