title: A simple synthesis of 18F-labelled 5-fluorouracil using acetylhypofluorite.
abstract: 18F-labelled 5-fluorouracil was synthesized by reacting labelled acetylhypofluorite in situ with uracil. Evaporation in the presence of triethylamine yielded 18F-5-fluorouracil in an overall radiochemical yield of about 20-30%. The solution was purified by passing it through a Sep-Pak column.
mesh_terms: D000085:Acetates; D004952:Esters; D005461:Fluorine; D005472:Fluorouracil / Q000138:chemical synthesis*; D011868:Radioisotopes
chemical_list: D000085:Acetates; D004952:Esters; D011868:Radioisotopes; D005461:Fluorine; C040801:acetyl hypofluorite; D005472:Fluorouracil