title: Computed tomography appearances in the linear sebaceous naevus syndrome.
abstract: The appearance of C.T. of the head in 11 cases of the linear sebaceous naevus syndrome are presented. From these it is argued that the pathology represents a disorder of neuronal migration and organisation rather than differentiation. Since three of the cases had evidence of CNS tumour in addition to two in the literature, it would appear that a further aspect of this disorder is a failure of growth constraint. This is paralleled by a similar tendency in the skin lesion which should be considered premalignant. Normal intelligence is rare in this condition and co-exists only with a normal C.T. scan. The early onset of fits is not necessarily associated with subsequent mental handicap.
mesh_terms: D001921:Brain / Q000002:abnormalities* / Q000000981:diagnostic imaging; D001932:Brain Neoplasms / Q000000981:diagnostic imaging*; D002114:Calcinosis / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D005153:Facial Neoplasms / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000000981:diagnostic imaging*; D009506:Nevus / Q000000981:diagnostic imaging*; D012626:Sebaceous Gland Neoplasms / Q000000981:diagnostic imaging*; D012886:Skull / Q000002:abnormalities / Q000000981:diagnostic imaging; D013577:Syndrome; D014057:Tomography, X-Ray Computed / Q000379:methods*