[3H]Kainic acid binding and choline acetyltransferase activity in Alzheimer's dementia.
The binding of [3H]kainic acid to caudate nucleus membranes prepared from brains of examples of Alzheimer's dementia and controls has been determined. No changes were detected in either the affinity or the number of kainate binding sites in the Alzheimer samples compared to control, although there was a large decrease in choline acetyltransferase activity.
D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D001665:Binding Sites; D002421:Caudate Nucleus / Q000032:analysis / Q000378:metabolism* / Q000473:pathology; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D005260:Female; D006801:Humans; D007608:Kainic Acid / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis; D011759:Pyrrolidines / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D011759:Pyrrolidines; D002795:Choline O-Acetyltransferase; D007608:Kainic Acid