Nature and incidence of serum precipitins against aeroallergens in non-atopic individuals.
Thirty-seven (74%) of 50 randomly selected non-atopic individuals gave precipitins against one or more of the seven common aeroallergen extracts surveyed by counterimmunoelectrophoresis. The precipitin lines could be absorbed out by antihuman IgG and homologous extracts, but were not affected by N-acetyl-glucosamine, protein A, heterologous extracts, heating, anti-reactive protein, anti-IgA, or anti-IgM. Our data suggest that the precipitins to allergen extracts are probably IgG3 and are more prevalent than had been previously reported in non-atopic individuals.
D000293:Adolescent; D000328:Adult; D000388:Air; D000485:Allergens / Q000276:immunology*; D000906:Antibodies / Q000032:analysis*; D000937:Antigen-Antibody Reactions; D003378:Counterimmunoelectrophoresis; D005312:Fetal Blood / Q000032:analysis; D006801:Humans; D011234:Precipitins / Q000097:blood*
D000485:Allergens; D000906:Antibodies; D011234:Precipitins