The derivation and use of mice which do not harbour lactobacilli in the gastrointestinal tract.
Penicillin treatment used in conjunction with germfree technology has allowed the derivation of a colony of BALB/c mice which do not harbour lactobacilli in the gastrointestinal tract. The animals continue to harbour Gram-negative anaerobes and coliforms, but not enterococci or filamentous segmented ileal microbes. Isolates of lactobacilli from rodents were able to colonize the gastrointestinal tract of the mice; and isolate from a fowl could not establish in these animals.
D000818:Animals; D004064:Digestive System / Q000382:microbiology*; D005260:Female; D007778:Lactobacillus / Q000187:drug effects / Q000254:growth & development*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000382:microbiology*; D008855:Microscopy, Electron, Scanning; D010400:Penicillin G / Q000494:pharmacology; D013270:Stomach / Q000382:microbiology
D010400:Penicillin G