Pregnancy and delivery in Ehlers-Danlos syndrome. Role of copper and zinc.
Two pregnancies of a patient with the mitis type of the Ehlers-Danlos syndrome (EDS) were followed up. The first pregnancy ended at 26 weeks. The second one proceeded to term, but the infant had a low birth weight and the placenta showed dysmaturity. In view of these pregnancies, the authors consider the vaginal route as an alternative to caesarean section for delivery of patients with the mitis type of EDS. In connection with both deliveries, serum zinc and copper levels were determined with the method of particle-induced X-ray emission (PIXE); the concentrations of both trace elements were low. The ceruloplasmin levels, on the other hand, were within the normal range. The relevance of these findings is discussed.
D000328:Adult; D002570:Ceruloplasmin / Q000378:metabolism; D003300:Copper / Q000097:blood*; D004535:Ehlers-Danlos Syndrome / Q000097:blood*; D005260:Female; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*; D015032:Zinc / Q000097:blood*
D003300:Copper; D002570:Ceruloplasmin; D015032:Zinc