title: Post-natal ontogenesis of graft-versus-host reactivity of peanut agglutinin lectin-negative thymocytes in the chicken.
abstract: Chicken thymocyte fractionation by peanut agglutinin lectin yields two cell subpopulations which differ in their GvH competence when injected into major histocompatibility complex (MHC)-(B locus) incompatible embryos. The nonagglutinated PNA- fraction displayed a degree of alloreactivity similar to that of peripheral blood lymphocytes while the PNA+ cells were nonreactive. Analysis of chickens at the age of 4 to 24 weeks showed that the development of GvH-reactive PBL preceded by 12 weeks the maturation of GvH-reactive PNA- thymocytes. Possible interpretations for this difference between the time of appearance of GvH reactivity of PNA- thymocytes and PBL are discussed.
mesh_terms: D000818:Animals; D010367:Arachis; D002642:Chick Embryo; D003433:Crosses, Genetic; D006087:Graft vs Host Reaction; D037102:Lectins; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D019887:Peanut Agglutinin; D037121:Plant Lectins; D013045:Species Specificity; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000254:growth & development* / Q000276:immunology
chemical_list: D037102:Lectins; D019887:Peanut Agglutinin; D037121:Plant Lectins