[Comparative study of the effect of ethacizin and lidocaine on the blood supply and function of the intact and ischemic myocardium].
It has been shown in experiments on cats anesthesized with nembutal that lidocaine (1.0 and 2.0 mg/kg) and etacizine (0.5 and 1.0 mg/kg) decrease heart work and create in the heart muscle a definite oxygen reserve, without exerting any inhibitory effect on myocardial contractile function. The drugs improve the function of the focus of myocardial ischemia, with the effect of etacizine being more lasting.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D002415:Cats; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D008012:Lidocaine / Q000627:therapeutic use*; D016293:Moricizine / Q000031:analogs & derivatives*; D010640:Phenothiazines / Q000627:therapeutic use*; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; C027240:diethylamino-ethmozine; D016293:Moricizine; D008012:Lidocaine
Sravnitel'noe izuchenie vliianiia étatsizina i lidokaina na krovosnabzhenie i funktsional'noe sostoianie intaktnogo i ishemizirovannogo miokarda.