Enhancing effect of sodium taurocholate on N-methyl-N'-nitro-N-nitrosoguanidine-induced stomach tumorigenesis in rats.
Male Wistar rats that had received a low dose of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and sodium taurocholate showed a significantly higher incidence of hyperplastic and neoplastic lesions in the stomach mucosa than did the MNNG-treated controls. The result suggested an enhancing effect of taurocholate in stomach tumorigenesis.
D000818:Animals; D004357:Drug Synergism; D008297:Male; D008769:Methylnitronitrosoguanidine; D051381:Rats; D011919:Rats, Inbred Strains; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology; D013656:Taurocholic Acid / Q000633:toxicity*
D008769:Methylnitronitrosoguanidine; D013656:Taurocholic Acid