[Micropenis. Results of treatment with testosterone].
Two groups of children presenting with micropenis (penis length less than or equal to 2.5 cm) were treated according to 2 different therapeutic schedules. The first consisted of the transcutaneous administration of testosterone propionate (4 mg twice a day) and the second of the intramuscular injection of sustained action testosterone enanthate (25 mg every 2 weeks). Only the intramuscular treatment was able to induce a normal and durable penis growth, owing to the hyperplastic action that the testosterone injection exerted on the level of the cellular tissues of the penis. Using testosterone enanthate dosages varying from 25 to 50 mg, the risks for an abnormal acceleration of growth and bone age seem to be minimized.
D000287:Administration, Topical; D000365:Age Determination by Skeleton; D002648:Child; D002675:Child, Preschool; D003692:Delayed-Action Preparations; D005500:Follow-Up Studies; D006128:Growth / Q000187:drug effects; D006801:Humans; D007223:Infant; D007273:Injections, Intramuscular; D008297:Male; D010413:Penis / Q000002:abnormalities*; D013739:Testosterone / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D003692:Delayed-Action Preparations; D013739:Testosterone
Micropénis. Résultats du traitement par la testostérone.