[Effect of adrenaline on nucleotide composition and the degree of DNA methylation in the canine myocardium].
Nucleotide composition and changes of 5-methylcytosine content (m5C) in DNA isolated from male-dogs' cardiac muscle (stomach) under the influence of adrenalin have been studied. After slow intravenous injection of adrenalin in extremal doses (7 mg during 5 days) quantity of m5C in DNA decreases in 1,2 times in comparison with the control. Is has been suggested that the decrease of DNA methylation by cytosine is possible as a result of increase of enzyme activity demethylizing DNA by cytosine and (or) inactivation of methilase specifically methylizing DNA by cytosine.
D044503:5-Methylcytosine; D000818:Animals; D003596:Cytosine / Q000031:analogs & derivatives / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D008297:Male; D008745:Methylation; D009206:Myocardium / Q000378:metabolism*; D009711:Nucleotides / Q000378:metabolism*
D009711:Nucleotides; D044503:5-Methylcytosine; D003596:Cytosine; D004247:DNA; D004837:Epinephrine
Vliianie adrenalina na nukleotidnyĭ sostav i stepen' metilirovaniia DNK v serdechnoĭ myshtse sobak.