The morphology and patency of arterial and venous microvascular anastomoses throughout the first post-operative year. A histological study.
End-to-end microvascular suture anastomoses, 40 arterial and 41 venous, from the rabbits carotid artery and posterior facial vein were harvested at 5 different time intervals (1, 2, 3, 6 and 12 months) post surgery and evaluated with light microscopy. A 100% long-term patency was noted both in arteries and veins. Quantitative measurements of the width of the vessel wall components indicated that a statistically significant temporary hypertrophic response occurred in the arterial intima, culminating in the third month when the width of the vessel wall at the anastomotic level almost doubled the normal. After that the width of the vessel wall again declined but it remained thicker than the adjacent vessel wall at one year post surgery. Among the venous anastomoses, however, the wall thickness at the anastomotic level remained thinner than the adjacent vessel wall throughout the evaluation period. The original vessel wall characteristics are not restored at the anastomotic site with intimal hyperplasia compensating for medial necrosis. Despite these events a technically satisfactory microvascular anastomosis should remain patent for years.
D000818:Animals; D001166:Arteriovenous Shunt, Surgical; D002339:Carotid Arteries / Q000473:pathology / Q000601:surgery*; D005145:Face / Q000098:blood supply; D006083:Graft Occlusion, Vascular; D006965:Hyperplasia; D006984:Hypertrophy; D011817:Rabbits; D013537:Sutures; D014680:Veins / Q000473:pathology / Q000601:surgery; D014945:Wound Healing