Primary intrasellar germinoma in a woman presenting with secondary amenorrhea and hyperprolactinemia.
A 32-year-old woman with secondary amenorrhea was found to have an elevated level of serum prolactin, partial diabetes insipidus, and a subtle visual field defect. A primary intrasellar tumor was noted on the computed tomographic scan. Although the tumor had some characteristics of a prolactinoma, transsphenoidal exploration revealed a primary germinoma. The tissue diagnosis led to appropriate treatment with radiotherapy. The tumor regressed, and the patient had a spontaneous pregnancy. Had dopamine agonists been used initially, amelioration of the hyperprolactinemia and delay in the proper diagnosis and treatment would have occurred.
D000328:Adult; D000568:Amenorrhea / Q000209:etiology*; D003131:Combined Modality Therapy; D003919:Diabetes Insipidus / Q000209:etiology; D004407:Dysgerminoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010902:Pituitary Gland / Q000473:pathology; D010910:Pituitary Irradiation; D010911:Pituitary Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D011247:Pregnancy; D011388:Prolactin / Q000097:blood*
D011388:Prolactin