Acquired paternal influence in mice. Altered serum antibody response in the progeny population of immunized CBA/H males.
First generation offspring derived from CBA/H males immunized in adult life against rat blood cell antigens displayed altered immune reactivity to rat erythrocytes (RE) as assayed at a single time point after challenge. For the low antigen challenge doses employed (10(6) to 10(7) RE i.p.) the population of test offspring showed a significant enhancement of serum antibody response relative to the control population of progeny of unimmunized males; at higher antigen challenge doses (10(8) RE i.p.) the response in the test progeny population was suppressed.
D000818:Animals; D000917:Antibody Formation; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007114:Immunization; D007125:Immunogenetics; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D010334:Paternity; D011247:Pregnancy; D051381:Rats