Lack of effect of haemodialysis on mebendazole kinetics: studies in a patient with echinococcosis and renal failure.
The effect of haemodialysis on mebendazole kinetics has been studied in a patient receiving both mebendazole therapy and haemodialysis. The procedure of haemodialysis did not influence the plasma concentration-time profiles or the mean daily plasma levels. The arterio-venous difference in the dialyser was negligible and no mebendazole could be detected in the dialysate. Protein binding of mebendazole was 90% before dialysis and 88% during dialysis and not significantly different from the binding in patients without renal disease (91.4 +/- 1.9%, n = 22).
D000328:Adult; D001562:Benzimidazoles / Q000378:metabolism*; D004443:Echinococcosis / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D007700:Kinetics; D008297:Male; D008463:Mebendazole / Q000378:metabolism* / Q000627:therapeutic use; D006435:Renal Dialysis
D001562:Benzimidazoles; D008463:Mebendazole