[Tumors secreting choriogonadotropin in children].
Fourteen cases of sexual precocity due to choriogonadotropin (hCG) secreting tumors are reported. One pineal and 4 gonadal tumors were observed in 5 girls, whilst 2 supra-sellar, 4 mediastinal, 1 gonadal and 2 hepatic tumors were observed in 9 boys. In all children, immunoreactive plasma LH was high (4 to 30 mIU/ml) but non-responsive to LH-RH, due to the presence of hCG (15 to 6,000 mIU/ml). In the 4 boys with mediastinal tumors the karyotype was 47,XXY. In girls, hCG secreting tumors are a uncommon cause of sexual precocity (less than 1 p. 100). In boys their incidence seems to be the same as the incidence of idiopathic precocious puberty, that is 21 p. 100 of sexual precocities due to androgenic secretion of testicular origin.
D000293:Adolescent; D001932:Brain Neoplasms / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D006063:Chorionic Gonadotropin / Q000378:metabolism*; D005260:Female; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000378:metabolism; D008297:Male; D008479:Mediastinal Neoplasms / Q000378:metabolism; D009369:Neoplasms / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000378:metabolism; D009384:Paraneoplastic Endocrine Syndromes / Q000209:etiology*; D011629:Puberty, Precocious / Q000209:etiology; D013736:Testicular Neoplasms / Q000378:metabolism
D006063:Chorionic Gonadotropin
Les tumeurs de l'enfant sécrétant de la choriogonadotropine.