Mental impairment in Parkinson's disease. The role of anticholinergic drugs.
The trial has been carried out on 33 treated Parkinsonian patients and 14 healthy controls. A series of psychometric tests were employed in order to show a possible intellectual deterioration in Parkinsonian patients. Bender's test showed greater motor-perceptive deterioration in Parkinsonian patients respect to control, the Wechsler-Bellevue Intelligence Scale evidenced in patients significant deterioration of mnesic and psychomotor capacity. When considering drug treatments patients undergoing combined treatment or anti-cholinergics alone obtained worse results in all tests made whilst patients on L-Dopa alone obtained the best results.
D000368:Aged; D003704:Dementia / Q000139:chemically induced*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D009966:Orphenadrine / Q000009:adverse effects; D010276:Parasympatholytics / Q000009:adverse effects*; D010300:Parkinson Disease / Q000188:drug therapy*; D014282:Trihexyphenidyl / Q000008:administration & dosage / Q000009:adverse effects
D010276:Parasympatholytics; D007980:Levodopa; D014282:Trihexyphenidyl; D009966:Orphenadrine