[The influence of drug liberation from drug forms on local therapy of infected bone cavities].
With regard to an optimum local pharmaco-therapy in infected bone cavities, in vitro examinations by means of a flow model based on the half-change method had been performed to liberate Gentamycin from globular embeddings in polymethylmethacrylate. The Gentamycin had been determined in a micro-biological manner. The release behaviour of the polymere carrier could be controlled by adding Polyethylenglycol 400 as softener or butane dioldimethacrylate as wettener. Adding 20 vol.-% of Polyethylenglycol 400, the Gentamycin release could be increased to the 8-fold, whereas the addition of 5 vol.-% of butane dioldimethacrylate resulted in a decrease amounting to 7/8 exit value.
D001424:Bacterial Infections / Q000188:drug therapy*; D001847:Bone Diseases / Q000188:drug therapy*; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D005839:Gentamicins / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D066298:In Vitro Techniques; D011092:Polyethylene Glycols
D003692:Delayed-Action Preparations; D005839:Gentamicins; D011092:Polyethylene Glycols
Untersuchungen zur Beeinflussung der Wirkstoffliberation aus Arzneiformen zur lokalen Therapie infizierter Knochenhöhlen.