[Influence of retinol acetate and carbon tetrachloride on the transplacental carcinogenic effect of N-nitrosoethylurea].
The influence of high doses of retinol acetate (RA) fed with the diet and carbon tetrachloride (CCl4) injected intraperitoneally into rat offspring on transplacental carcinogenic effect of N-nitrosoethylurea (NEU) was studied. Neither RA nor CCl4 affected significantly the development of the nervous system and kidney tumors induced transplacentally by NEU. CCl4 did not induce liver tumors either under these conditions. Obviously, it is rather difficult to modify the transplacental carcinogenesis.
D000818:Animals; D000831:Animals, Newborn; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D004224:Diterpenes; D004347:Drug Interactions; D005038:Ethylnitrosourea / Q000494:pharmacology*; D005260:Female; D007680:Kidney Neoplasms / Q000139:chemically induced*; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D009423:Nervous System Neoplasms / Q000139:chemically induced*; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D010920:Placenta / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D000084562:Retinyl Esters; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology
D004224:Diterpenes; D009607:Nitrosourea Compounds; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate; D002251:Carbon Tetrachloride; D005038:Ethylnitrosourea
Vliianie retinola atsetata i chetyrekhkhloristogo ugleroda na transplatsentarnyĭ kantserogennyĭ éffekt N-nitrozoétilmocheviny.