title: Nondisjunction frequencies in Robertsonian heterozygotes from natural populations of the common shrew, Sorex araneus L.
abstract: Pregnant female common shrews were collected from an area of Robertsonian polymorphism, involving five different arm combinations, around Oxford (England). The females and their fetuses were karyotyped, and the karyotypes of the sires were deduced. Ten pregnancies where at least one parent was known to be either a single or double Robertsonian heterozygote were available for analysis. From these pregnancies, upper and lower estimates of anaphase I nondisjunction arising from Robertsonian heterozygosity were calculated to be 1.0-2.5% per heterozygous arm combination and 1.5-3.7% per heterozygous parent. One trisomic fetus with retarded development was identified. This trisomy can be attributed to anaphase I nondisjunction of a trivalent in a female Robertsonian heterozygote.
mesh_terms: D000818:Animals; D002871:Chromosome Banding; D005260:Female; D005333:Fetus; D006579:Heterozygote; D007621:Karyotyping; D009630:Nondisjunction, Genetic; D011110:Polymorphism, Genetic; D011247:Pregnancy; D012788:Shrews / Q000235:genetics*; D014314:Trisomy