title: [Cytotoxic activity of large granular lymphocytes (LGL) infiltrated into metastatic tumors of lung cancer].
abstract: Large granular lymphocytes (LGL) showing Leu 7 and weak E rosettes were separated from two metastatic tumors of lung cancer. Weak cytotoxic activity of these cells was recognized against autochthonous tumors, but never against K-562 cells. After OK-432 therapy, this cytotoxicity was not enhanced, but antibody dependent cell-mediated cytotoxicity (ADCC) of peripheral blood mononuclear cells of the patient was induced against metastatic tumors. These signs may suggest that specific immunotherapy should be available for these cancers.
mesh_terms: D000920:Antibody-Dependent Cell Cytotoxicity; D002276:Carcinoid Tumor / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008175:Lung Neoplasms / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D008207:Lymphatic Metastasis; D008875:Middle Aged; D010844:Picibanil / Q000627:therapeutic use
chemical_list: D010844:Picibanil