Anti-androgens do not alter androgen-dependent characteristics of acid phosphatase in the rat ventral prostate.
When administered to intact adult male rats, cyproterone acetate (10 mg/day), flutamide (15 mg/day), or Compound I (1 mg/day) caused a significant decrease in the organ weight to body weight ratios, with a concomitant rise in the specific activity of prostatic acid phosphatase. These compounds do not affect two other markers of androgen activity in the prostate. Neither the percentage inhibition of acid phosphatase activity by tartrate nor the appearance of the secretory band of acid phosphatase on polyacrylamide gels was altered by the administration of anti-androgens. When administered to castrated rats given doses of 5 alpha-dihydrotestosterone (250-750 micrograms/day), flutamide (15 mg/day) was unable to alter the percentage inhibition of acid phosphatase activity by tartrate, or the pattern of activity on polyacrylamide gels. These results suggest that these anti-androgens affect only some of the androgen-dependent functions of the prostate.
D000135:Acid Phosphatase / Q000032:analysis*; D000726:Androgen Antagonists / Q000378:metabolism / Q000494:pharmacology*; D000728:Androgens / Q000502:physiology*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002369:Castration; D013196:Dihydrotestosterone / Q000494:pharmacology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains
D000726:Androgen Antagonists; D000728:Androgens; D013196:Dihydrotestosterone; D000135:Acid Phosphatase