title: Effect of zinc supplementation on copper status in adult man.
abstract: The effects of zinc supplementation on the copper status of healthy adult men, as assessed by the activities of the copper-metalloenzymes, plasma ferroxidase (ceruloplasmin), and erythrocyte Cu,Zn-superoxide dismutase, were determined. The subjects were given either two daily doses of 25 mg zinc or placebo for 6 wk. No significant differences in the plasma copper levels or the ferroxidase activities between the supplemented and control groups could be detected at 2, 4, or 6 wk. Plasma zinc increased and erythrocyte Cu,Zn-superoxide dismutase decreased in the supplemented group, the difference between the groups becoming significant at 6 wk (p less than 0.05). This suggested that the zinc supplements decreased the copper status of the experimental group.
mesh_terms: D000328:Adult; D002570:Ceruloplasmin / Q000378:metabolism; D003300:Copper / Q000097:blood* / Q000172:deficiency; D004032:Diet; D004912:Erythrocytes / Q000201:enzymology*; D006801:Humans; D008099:Liver / Q000201:enzymology; D008297:Male; D013482:Superoxide Dismutase / Q000097:blood; D015032:Zinc / Q000009:adverse effects* / Q000097:blood
chemical_list: D003300:Copper; D013482:Superoxide Dismutase; D002570:Ceruloplasmin; D015032:Zinc