[A quantitative morphologic study of cancellous bone--comparative study between physiological and pathological bone loss in autopsy cases].
The morphologic measurement of bone volume was made by using the lower lumbar vertebrae of 905 cases which were selected from 1,200 consecutive autopsy cases. The tendency and the degree of bone loss, under various pathological conditions and for aging, were compared and examined. Microscopic specimens of the lumbar vertebrae without bone marrow were used as source material and the dimensional ratios of the trabecular bone were calculated by video image processor (VIP). It is already well known that disappearance of transverse trabeculae first occurs in the progress of osteoporotic change, but in this study no clear difference appeared in the comparison of the dimensional ratios between the transverse and vertical trabeculae. On comparison between males and females in the control group, the loss of bone volume in females starts in the fifth decade with a rather rapid progress, while it starts gradually from the sixth decade in males. As regards the group with the diseases compared, the loss of bone volume appears very high for every age with high dose steroid hormone therapy and chronic renal failure but the group characterized by hypertensive vascular disorders showed an insignificant difference in comparison to the control group. In the group with malignant tumors, with liver cirrhosis and with heavy drinkers, the loss of bone volume appears to be considerable in younger individuals but no difference from the controls could be found in older individuals. In the group with diabetes mellitus, the bone volume appears to a high degree in younger individuals and the loss of bone volume makes for an accelerated increase in older individuals. This tendency is very different from the other diseased group. It can be considered that the mechanism of bone loss is accelerated with aging and various pathological factors together.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D000437:Alcoholism / Q000150:complications; D001862:Bone Resorption / Q000473:pathology*; D002648:Child; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D007676:Kidney Failure, Chronic / Q000150:complications; D008103:Liver Cirrhosis / Q000150:complications; D008159:Lumbar Vertebrae / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications; D010014:Osteolysis / Q000209:etiology / Q000473:pathology*; D011239:Prednisolone / Q000009:adverse effects; D012737:Sex Factors
D011239:Prednisolone