Inhibition of Na-alanine cotransport in oocytes of Xenopus laevis during meiotic maturation is voltage-regulated.
During progesterone-induced maturation of oocytes of Xenopus laevis the fast decrease of the rate of Na+-alanine cotransport is accompanied by a depolarization of the membrane potential and an increase in the intracellular Na+ activity. It is demonstrated that the decrease of the Na+-dependent alanine uptake is the result of the depolarization while the simultaneous increase in intracellular Na+ activity has no significant effect.
D000409:Alanine / Q000378:metabolism*; D000818:Animals; D004594:Electrophysiology; D005260:Female; D008540:Meiosis; D008564:Membrane Potentials / Q000187:drug effects; D008677:Metaphase; D008839:Microelectrodes; D009865:Oocytes / Q000378:metabolism* / Q000502:physiology; D009866:Oogenesis; D011374:Progesterone / Q000494:pharmacology; D011418:Prophase; D012964:Sodium / Q000378:metabolism*; D014982:Xenopus laevis
D011374:Progesterone; D012964:Sodium; D000409:Alanine