Studies on new antiplatelet agents, WS-30581 A and B.
WS-30581 A and B are antiplatelet agents produced by a strain of Streptoverticillium waksmanii. The compounds were purified by solvent extraction and column chromatography, and identified as new pimprinine analogs on the basis of their physico-chemical properties. The producing organism produced pimprinine along with these compounds. Pimprinine and the two new analogs have potent inhibitory effects on platelet aggregation.
D000818:Animals; D005343:Fibrinolytic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D010080:Oxazoles / Q000302:isolation & purification*; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D013306:Streptomycetaceae / Q000145:classification / Q000378:metabolism
D005343:Fibrinolytic Agents; D010080:Oxazoles; C043673:WS 30581B; C043672:WS 30581A