[Relation between acute changes in diuresis and renal prostaglandins. I: Induced hypotonic polyuria].
We have evaluated the effects of indomethacin (I) and of a rich in linoleic acid phosphatidylcholine (E) on the renal function and on the PGE urinary excretion during steady hypotonic polyuria. 5 normal subjects have been studied in the absence of treatment (TA) and after treatment with I, E, E + I. The renal function has been estimated by clearance (cl.) method during hypotonic polyuria induced by oral water loading and i.v. infusion of 5% dextrose solution. The glomerular filtration rate has been estimated by cl. of endogenous creatinine; moreover have been measured the osmotic clearances (Cosm, CH2O), the sodium and potassium clearances (CNa, CK), the mean arterial pressure (PA) and the urinary prostaglandins of E series (PGE) by RIA method. In I condition is observed: a) a trend to a glomerular filtration rate decrement; b) a significant decline of the urinary flow rate, CH2O, UPGV and a significant increment of the urinary osmolarity; c) a trend to an increment of potassium and a decrement of sodium urinary excretions; d) a significant increase of PA. It is possible that the contrary effects observed during the hypotonic polyuria in E condition depend on the stimulating effects of this material on the PG intrarenal synthesis.
D000328:Adult; D004231:Diuresis / Q000187:drug effects; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology; D007677:Kidney Function Tests; D019787:Linoleic Acid; D008041:Linoleic Acids; D009318:Natriuresis; D010713:Phosphatidylcholines / Q000494:pharmacology; D011141:Polyuria / Q000652:urine*; D011188:Potassium / Q000652:urine; D011458:Prostaglandins E / Q000652:urine*
D008041:Linoleic Acids; D010713:Phosphatidylcholines; D011458:Prostaglandins E; D019787:Linoleic Acid; D011188:Potassium; D007213:Indomethacin
Relazione tra variazioni acute della diuresi e prostaglandine renali. I: Poliuria ipotonica provocata.