Synergistic anticonvulsant effects of a GABA agonist and glycine.
Administration of muscimol to mice in subcutaneous doses between 0.34 and 1.25 mg/kg produced partial protection against 3-mercaptopropionic acid (MPA)-induced seizures. Glycine at a dose of 750 mg/kg (10 mmol/kg) protected 20% of the animals 45 min after its administration. Combined treatment with the two compounds gave a near to complete protection against MPA-induced seizures. These observations suggest that the concomitant enhancement of glycinergic and GABAergic activities amplify the anticonvulsant effect of these neuronal systems against seizures induced by impairment of GABA-mediated transmission.
D015097:3-Mercaptopropionic Acid; D000818:Animals; D000927:Anticonvulsants; D004357:Drug Synergism; D005998:Glycine / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009118:Muscimol / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D000927:Anticonvulsants; D010080:Oxazoles; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D015097:3-Mercaptopropionic Acid; D005998:Glycine