Together intracranial angiotensin and systemic mineralocorticoid produce avidity for salt in the rat.
Rats that have no need for sodium will run to small rewards of 3% NaCl solution in a runway after they have been treated with both a mineralocorticoid and angiotensin II. When given alone at the low doses used here, neither the mineralocorticoid nor the angiotensin produce the behavior. This result encourages the idea that it is a synergy of the hormones of sodium conservation, angiotensin and aldosterone, that apprises the brain of the need for salt and generates the appetite for the taste of salt.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001066:Appetite / Q000187:drug effects*; D001070:Appetitive Behavior / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects; D003900:Desoxycorticosterone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012462:Saline Solution, Hypertonic; D012646:Self Administration; D012965:Sodium Chloride / Q000008:administration & dosage*; D013894:Thirst / Q000187:drug effects; D014868:Water Deprivation
D012462:Saline Solution, Hypertonic; D000804:Angiotensin II; D003900:Desoxycorticosterone; D012965:Sodium Chloride