Moderate homocysteinemia--a possible risk factor for arteriosclerotic cerebrovascular disease.
Highly elevated concentrations of homocysteine measured as homocysteine or cysteine-homocysteine mixed disulfide (MDS) are found in plasma and urine in subjects with inherited abnormalities of the methionine metabolism. These subjects have a high incidence of arteriosclerotic vascular complications during childhood. Homocysteine causes endothelial cell injury and cell detachment that initiates the development of arteriosclerosis. The present study demonstrates a significantly elevated mean plasma MDS concentration in 19 patients with arteriosclerotic cerebrovascular disease compared to 17 controls. Our findings suggest that moderate homocysteinemia might be a risk factor for arteriosclerotic cerebrovascular disease.
D000328:Adult; D002561:Cerebrovascular Disorders / Q000097:blood; D002784:Cholesterol / Q000097:blood; D003541:Cystathionine beta-Synthase / Q000172:deficiency; D003553:Cystine / Q000097:blood; D004151:Dipeptides / Q000097:blood; D005260:Female; D005492:Folic Acid / Q000097:blood; D006710:Homocysteine / Q000097:blood*; D006712:Homocystinuria / Q000150:complications; D006801:Humans; D002537:Intracranial Arteriosclerosis / Q000097:blood / Q000209:etiology*; D002546:Ischemic Attack, Transient / Q000097:blood; D008297:Male; D008715:Methionine / Q000097:blood / Q000378:metabolism; D008875:Middle Aged; D012306:Risk; D012907:Smoking; D014280:Triglycerides / Q000097:blood; D014805:Vitamin B 12 / Q000097:blood
D004151:Dipeptides; D014280:Triglycerides; D006710:Homocysteine; D003553:Cystine; C022802:cysteinylhomocysteine mixed disulfide; D005492:Folic Acid; D002784:Cholesterol; D008715:Methionine; D003541:Cystathionine beta-Synthase; D014805:Vitamin B 12