title: High-performance liquid chromatographic determination of the nitrate esters isosorbide dinitrate, pentaerythritol tetranitrate, and erythrityl tetranitrate in various tablet forms.
abstract: A reliable, sensitive, and specific assay for isosorbide dinitrate pentaerythritol tetranitrate, and erythrityl tetranitrate in sublingual, uncoated, sustained-release, and chewable dosage forms, using high-performance liquid chromatography, is described. The nitrate ester dosage forms were dissolved in methanol, filtered, and injected directly into the liquid chromatograph. A variable-wavelength UV detector, operated at 220 nm, and a reverse-phase C18 microporous silica column were employed. The mobile phase was methanol-water (40:60). The proposed method is quantitative and reproducible.
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004897:Erythrityl Tetranitrate / Q000032:analysis*; D007548:Isosorbide Dinitrate / Q000032:analysis*; D010417:Pentaerythritol Tetranitrate / Q000032:analysis*; D013607:Tablets
chemical_list: D013607:Tablets; D010417:Pentaerythritol Tetranitrate; D004897:Erythrityl Tetranitrate; D007548:Isosorbide Dinitrate