[Effect of 1,2:5,6-dianhydrogalactitol and 1,2:5,6-dianhydro-3,4-diacetylgalactitol on DNA synthesis in the cells of melanoma B16, bone marrow, small intestine epithelium, spleen and liver of mice].
Alterations in DNA synthesis induced by 1,2:5,6-dianhydrogalactitol (DAG) and 1,2:5,6-dianhydro-3,4-diacetyldianhydrocalactitol (Diac-DAG) were studied in host normal cells and tumor cells. After administration of these antitumor drugs to melanoma B16-bearing mice, DNA synthesis in host tissues (bone marrow, gastrointestinal mucosa, spleen, liver) got recovered more rapidly than DNA synthesis in melanoma B16. Diac-DAG differed from DAG from the standpoint of damage to DNA synthesis in normal cells. Only DAG inhibited the DNA synthesis in liver cells. Inhibition of DNA synthesis in the bone marrow and spleen with Diac-DAG was less remarkable than with DAG.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis*; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D003961:Dianhydrogalactitol / Q000031:analogs & derivatives / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008545:Melanoma / Q000188:drug therapy / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013402:Sugar Alcohols / Q000494:pharmacology*; D013997:Time Factors
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D013402:Sugar Alcohols; D003961:Dianhydrogalactitol; C027991:dianhydro-3,4-diacetylgalactitol; D004247:DNA
Vliianie 1,2:5,6-diangidrogalaktitola i 1,2:5,6-diangidro-3,4-diatsetilgalaktitola na sintez DNK v kletkakh melanomy B16, kostnogo mozga, épiteliia tonkogo kishechnika. selezenki i pecheni mysheĭ.