Inflammation-induced increases in dolichol synthesis and hydroxymethylglutaryl-coenzyme A reductase activity in mouse liver are prevented by a high-cholesterol diet but not by fasting.
The inflammatory response in mammals is characterized by the synthesis in the liver of several N-linked serum glycoproteins called acute-phase reactants. In C57BL/6J mice, turpentine-induced inflammation was accompanied by increases in 3-hydroxy-3-methylglutaryl-coenzyme A reductase activity, dolichol synthesis, and dolichyl phosphoryl mannose synthesis. Cholesterol feeding, but not fasting, prevented these inflammation-induced increases in reductase activity and dolichol synthesis. However, the rate of incorporation of [3H]mannose into total serum glycoproteins was not affected by the high-cholesterol diet, and this rate increased during acute inflammation in control and cholesterol-fed mice.
D000085:Acetates / Q000378:metabolism; D019342:Acetic Acid; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D004224:Diterpenes / Q000096:biosynthesis*; D004287:Dolichol Monophosphate Mannose / Q000096:biosynthesis; D004286:Dolichols / Q000096:biosynthesis*; D005215:Fasting; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008862:Microsomes, Liver / Q000378:metabolism; D014316:Tritium
D000085:Acetates; D002791:Cholesterol, Dietary; D004224:Diterpenes; D004286:Dolichols; D014316:Tritium; D004287:Dolichol Monophosphate Mannose; D006903:Hydroxymethylglutaryl CoA Reductases; D019342:Acetic Acid