The biological functions of low-frequency vibrations (phonons). 4. Resonance effects and allosteric transition.
Based on the internal structure of oligoprotein as well as the basic physical characteristics+ of vibrations, it is deduced that the low-frequency vibrations possess some exceptional functions in transmitting biological information at the molecular level. In particular, according to the viewpoint of energy exchange and intramolecular displacement, it is demonstrated that the low-frequency resonance plays a very significant role during the dynamic process of allosterism of an oligomeric protein molecule. Furthermore, the cooperative reaction between hemoglobins and ligands is taken as an example, through which it is seen that some observed phenomena, whose dynamic principle has thus far been unclear, can be explicitly interpreted in terms of the concept of low-frequency resonance.
D000494:Allosteric Regulation; D000595:Amino Acid Sequence; D000818:Animals; D006454:Hemoglobins; D006860:Hydrogen Bonding; D046911:Macromolecular Substances; D008433:Mathematics; D008958:Models, Molecular; D011487:Protein Conformation; D011506:Proteins; D014732:Vibration
D006454:Hemoglobins; D046911:Macromolecular Substances; D011506:Proteins