title: A study of cyanide-insensitive respiration in the genus Dekkera and Brettanomyces.
abstract: Dekkera intermedia and Brettanomyces custersii were shown to have a respiratory pathway resistant to cyanide, antimycin A, and azide. This respiration remained sensitive to salicylhydroxamic acid (SHAM). The "cyanide-resistant" respiration was induced mainly at the end of the growth phase and could reach 50% of total respiratory capacity. The mitochondrial "petite colony" mutation had no effect on this oxidation pathway. The presence of this respiration pathway in these strains constitutes a compensation mechanism for the reducing activity of acetaldehyde dehydrogenase. This alternate pathway would thus be a fundamental element of the Custer effect, a characteristic feature of these strains.
mesh_terms: D000445:Aldehyde Oxidoreductases / Q000378:metabolism; D003486:Cyanides / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D009154:Mutation; D010101:Oxygen Consumption / Q000187:drug effects; D012457:Salicylamides / Q000494:pharmacology; D013045:Species Specificity; D015003:Yeasts / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*
chemical_list: D003486:Cyanides; D012457:Salicylamides; C005703:salicylhydroxamic acid; D000445:Aldehyde Oxidoreductases; C018699:aldehyde dehydrogenase (NAD(P)+)