Kinetics of digitoxin and the bis- and monodigitoxosides of digitoxigenin in normal subjects.
The kinetics of digitoxin and two of its metabolites, the bis- and monodigitoxosides of digitoxigenin, were determined in six normal subjects. Mean t 1/2s and total body clearances were 134.4, 15.4, and 0.59 hr and 2.66, 27.3, and 1071 ml/min. Mean renal clearance of the monodigitoxoside was more rapid (7.24 ml/min) than those of digitoxin (0.81 ml/min) or the bisdigitoxoside (0.94 ml/min). The volumes of distribution were of the same order, 0.45 l/kg for digitoxin, 0.57 l/kg for the bisdigitoxoside, and 0.83 l/kg for the monodigitoxoside. The short t 1/2 of monodigitoxoside would make it unsuitable for clinical use, but the bisdigitoxoside of digitoxigenin has a t 1/2 of an intermediate length and may have significant therapeutic advantages.
D000328:Adult; D000368:Aged; D004073:Digitoxigenin / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000652:urine; D004074:Digitoxin / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004341:Drug Evaluation; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D004073:Digitoxigenin; C038148:digitoxigenin-bis(digitoxoside); C035486:digitoxigenin monodigitoxoside; D004074:Digitoxin