Case report of barbiturate-induced enhancement of methadone metabolism and withdrawal syndrome.
A methadone maintenance patient with a decreased plasma methadone level, possibly due to phenobarbital-induced acceleration of methadone biotransformation, experienced opioid withdrawal symptoms. This finding suggests that when phenobarbital is used with methadone the plasma methadone level must be monitored.
D000328:Adult; D001711:Biotransformation; D005260:Female; D006556:Heroin Dependence / Q000378:metabolism / Q000534:rehabilitation*; D006801:Humans; D008297:Male; D008691:Methadone / Q000097:blood* / Q000378:metabolism / Q000627:therapeutic use; D010634:Phenobarbital / Q000009:adverse effects*; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
D008691:Methadone; D010634:Phenobarbital