Warfarin interaction with erythromycin.
The drug interaction between warfarin and erythromycin is not well known. We report a case in which erythromycin was observed to markedly potentiate warfarin anticoagulation, resulting in hemorrhage in a patient treated for Legionella pneumonia. The morbidity of this drug interaction is enhanced in elderly patients who have infection accompanied by anorexia and/or fever and who are receiving intravenous erythromycin. The well-documented, temporal relationship established erythromycin as the interacting drug.
D004347:Drug Interactions; D004917:Erythromycin / Q000009:adverse effects / Q000031:analogs & derivatives*; D006469:Hemoptysis / Q000139:chemically induced*; D006801:Humans; D007877:Legionnaires' Disease / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D014859:Warfarin / Q000009:adverse effects*
C010948:erythromycin lactobionate; D014859:Warfarin; D004917:Erythromycin