Some observations on vinca alkaloid and ethanol neurotoxicity using dissociated neuronal cultures.
Dissociated neuronal cultures have become a popular tool to address a number of questions in neurobiology. These culture systems may provide useful paradigms to approach problems related to in vivo neurotoxicity of xenobiotics. The clinical spectra of vinca neurotoxicity and alcohol teratogenesis is reviewed, and some observations on the use of dissociated cultures to study neuronal toxicity of vinca alkaloids and alcohol are presented.
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D000431:Ethanol / Q000633:toxicity*; D007928:Lethal Dose 50; D009474:Neurons / Q000187:drug effects*; D009475:Neurons, Afferent / Q000187:drug effects; D010944:Plants / Q000032:analysis; D014748:Vinca Alkaloids / Q000633:toxicity*; D014750:Vincristine / Q000633:toxicity
D014748:Vinca Alkaloids; D000431:Ethanol; D014750:Vincristine