[Hepatitis secondary to a gold salt overdose].
The authors report the case of a 51-year-old woman who developed cholestatic and cytolytic hepatitis after an overdose of sodium aurothiopropanol sulfonate 1.1 g, namely 300 mg gold metal. Liver biopsy demonstrated cholestasis, centrolobular steatosis and portal fibrosis. Electron microscopy showed abundant lipo-pigments in the hepatic and cellular cells, as well as myelinic bodies. Gold analysis by atomic absorption spectroscopy showed a level of 22.76 micrograms per ml in the plasma and a level of 2.16 micrograms per g in the liver. Chelating agents increased the urinary gold excretion, but were without effect on the course of hepatitis. Dimercaptopropanol seemed to favor the occurrence of other gold salt side-effects and penicillamine increased the hepatic cytolysis. The patient recovered without sequelae.
D000893:Anti-Inflammatory Agents / Q000009:adverse effects* / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced*; D004112:Dimercaprol / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism; D005260:Female; D005500:Follow-Up Studies; D006046:Gold / Q000009:adverse effects* / Q000097:blood / Q000378:metabolism; D006801:Humans; D008875:Middle Aged; D050607:Organogold Compounds; D009942:Organometallic Compounds; D020005:Propanols; D013438:Sulfhydryl Compounds
D000893:Anti-Inflammatory Agents; D050607:Organogold Compounds; D009942:Organometallic Compounds; D020005:Propanols; D013438:Sulfhydryl Compounds; D004112:Dimercaprol; D006046:Gold; C013394:aurotioprol
Hépatite secondaire à un surdosage en un sel d'or.