Effects of di-2-ethylhexyl phthalate on lipid composition of serum and testis in rats.
Dietary administration of di-2-ethylhexyl phthalate (DEHP; 2%) to male rats caused testicular atrophy. Serum non-esterified fatty acid increased while cholesterol, triglyceride and phospholipid decreased in treated rats. Testicular concentration of cholesterol and non-esterified fatty acid increased in DEHP-treated rats. Fatty acid composition of phospholipid and triglyceride were also changed. These changes were similar to those in rats fed a zinc(Zn)-deficient diet.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004051:Diethylhexyl Phthalate / Q000633:toxicity*; D005227:Fatty Acids / Q000032:analysis; D008055:Lipids / Q000032:analysis* / Q000097:blood; D008099:Liver / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010743:Phospholipids / Q000032:analysis; D010795:Phthalic Acids / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000032:analysis* / Q000187:drug effects; D014280:Triglycerides / Q000032:analysis; D015032:Zinc / Q000032:analysis*
D005227:Fatty Acids; D008055:Lipids; D010743:Phospholipids; D010795:Phthalic Acids; D014280:Triglycerides; D004051:Diethylhexyl Phthalate; D015032:Zinc