title: Regulated transcription of c-Ki-ras and c-myc during compensatory growth of rat liver.
abstract: We examined the transcription of six cellular oncogenes during the process of compensatory growth in rat liver after partial hepatectomy. We have previously reported that transcripts of c-rasH are elevated during regenerative growth of the liver. We now report that transcripts of c-rasK and c-myc genes are significantly elevated after partial hepatectomy, whereas transcripts of c-abl and c-src are essentially unchanged and transcripts of c-mos are undetectable in either normal or regenerating rat liver. In liver regeneration after partial hepatectomy or chemical injury, changes in c-myc transcripts occur before DNA synthesis. The elevation of c-myc and c-ras transcripts is sequential in that highest levels of c-myc transcripts were detected 12 to 18 h after partial hepatectomy, whereas the levels of c-rasH and c-rasK were maximal by 36 to 48 h. Transcripts of all three activated oncogenes returned to their basal levels by 96 h.
mesh_terms: D000818:Animals; D004261:DNA Replication; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008115:Liver Regeneration; D008297:Male; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D051381:Rats; D013997:Time Factors; D014158:Transcription, Genetic