[Effect of the size of the ligand molecule on the stability of the DNA double helix].
The influence of ligand length on helix-coil transition parameters in the presence of different ligand concentrations has been considered theoretically. A decrease of this influence with an increase of ligand length when the binding constant has a constant value was shown. When binding free energy is proportional to the ligand length, i. e. when K = K0m (K-binding constant, m-ligand length) the length effect is unambigous. In the presence of low-ligand concentration the stability of DNA double helix increases with their length, whereas in the presence of high concentrations it decreases.
D004247:DNA / Q000378:metabolism*; D007700:Kinetics; D008024:Ligands / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D009691:Nucleic Acid Denaturation; D013696:Temperature
D008024:Ligands; D004247:DNA
O vliianii razmerov molekul ligandov na stabil'nost' dvoĭnoĭ spirali DNK.