Adrenal changes in genetically hypothyroid mice.
The adrenocortical X-zone was very poorly developed in young female mice homozygous for the hypothyroid, hyt, mutation, Feeding the mice thyroid powder resulted in the development of an X-zone. This subsequently degenerated in the same way as the X-zone found in the normal litter-mates of the mutants. We suggest that the adrenocortical effects may be due to changes in prolactin stimulation consequent upon the lack of response to thyrotrophin of the mutants.
D000302:Adrenal Cortex / Q000254:growth & development* / Q000473:pathology; D000818:Animals; D005260:Female; D007037:Hypothyroidism / Q000473:pathology / Q000503:physiopathology*; D051379:Mice; D008817:Mice, Mutant Strains; D013962:Thyroid (USP) / Q000494:pharmacology
D013962:Thyroid (USP)