[Effect of selenium on transplacental carcinogenesis].
The effect of prolonged postnatal treatment with sodium selenite dissolved in drinking water upon transplacental carcinogenicity of N-ethyl-N-nitrosourea (ENU) was studied in noninbred albino rats and that of urethan in noninbred albino mice. Selenium treatment (4 ppm) did not produce a significant influence upon the development of neurogenic tumors and mesenchymal kidney tumors induced by transplacental administration of ENU (75 mg/kg) in rat offsprings. On the contrary, in mice progeny, selenium (2 ppm) showed an inhibitory effect upon the development of lung adenomas induced by transplacental administration of urethan (1 g/kg). However, it decreased significantly tumor multiplicity only. Inhibition of non-epithelial tumor development by selenium treatment seems to be less effective at the stage of carcinogenesis promotion.
D000818:Animals; D004336:Drug Antagonism; D005038:Ethylnitrosourea; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000517:prevention & control; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced / Q000517:prevention & control; D009423:Nervous System Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D012643:Selenium / Q000494:pharmacology*; D014520:Urethane
D014520:Urethane; D012643:Selenium; D005038:Ethylnitrosourea
Vliianie selena na transplatsentarnyĭ kantserogenez.