title: The pharmacokinetics of fenbendazole and oxfendazole in cattle.
abstract: The pharmacokinetics of fenbendazole and oxfendazole in cattle are described. The pharmacokinetics of oxfendazole were not significantly different when administered orally and by intra-ruminal injection. At a dose rate of 4.5 mg/kg, administered orally, fenbendazole gave rise to mean peak concentrations in plasma of fenbendazole and oxfendazole of 0.11 and 0.13 microgram/ml respectively. Oral administration of oxfendazole, at 4.5 mg/kg body weight, gave rise to plasma peak concentrations of fenbendazole and oxfendazole of 0.10 and 0.20 microgram/ml respectively. Following intra-ruminal administration of oxfendazole, the peak concentrations were 0.11 and 0.18 microgram/ml respectively.
mesh_terms: D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage / Q000378:metabolism*; D002417:Cattle / Q000378:metabolism*; D002418:Cattle Diseases / Q000188:drug therapy; D005260:Female; D005273:Fenbendazole / Q000008:administration & dosage / Q000378:metabolism*; D007700:Kinetics; D008297:Male
chemical_list: D001562:Benzimidazoles; D005273:Fenbendazole; C011030:oxfendazole