title: Hypoxic moderation of renal hypertension in the miniature swine.
abstract: Eleven male Yucatan miniature swine were subjected to unilateral renal artery constriction (RAC) with an intact contralateral kidney. Five pigs remained at laboratory altitude of 1524 m and served as normoxic, hypertensive controls (NH) while the other six (HH) were subjected to a simulated altitude of 4267 m for 9 weeks to determine the effect of hypoxia on the development of renal hypertension. Systemic blood pressure was increased less in HH as compared with NH. Data from three sib-pairs represented in each treatment group suggested a diverse, apparently familial response to RAC. The hypertensive process, irrespective of treatment groups, included a diminution of free circulating serum thyroxin and an increase in serum sodium. Hypoxia moderates renal hypertension in the miniature pig primarily via a decrement in stroke volume and cardiac output.
mesh_terms: D000818:Animals; D001274:Atmospheric Pressure; D001794:Blood Pressure; D002302:Cardiac Output; D003250:Constriction; D006977:Hypertension, Renal / Q000150:complications / Q000235:genetics / Q000503:physiopathology*; D000860:Hypoxia / Q000150:complications / Q000503:physiopathology*; D008297:Male; D011188:Potassium / Q000652:urine; D012077:Renal Artery / Q000502:physiology; D012964:Sodium / Q000378:metabolism; D013318:Stroke Volume; D013552:Swine; D013556:Swine, Miniature; D013974:Thyroxine / Q000097:blood
chemical_list: D012964:Sodium; D013974:Thyroxine; D011188:Potassium