Trichothecenes, 1: The synthesis of 4-deoxyverrucarol from verrucarol and diacetoxyscirpenol.
4-Deoxyverrucarol (4) has been synthesized for use in studies for the preparation and development of monoclonal antibodies for trichothecenes. Both verrucarol (1) and anguidine (2) have been converted to deoxyverrucarol (DOVE) (4) by deoxygenation at C3 and at C3 and C4, respectively.
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D007928:Lethal Dose 50; D051379:Mice; D012717:Sesquiterpenes / Q000138:chemical synthesis*; D014255:Trichothecenes / Q000138:chemical synthesis* / Q000633:toxicity
D000972:Antineoplastic Agents, Phytogenic; D012717:Sesquiterpenes; D014255:Trichothecenes; C011140:verrucarol; C042673:4-deoxyverrucarol; C001809:diacetoxyscirpenol