[The effect of preparations of microbial glutamin(asparagin)ase on cultured tumor cells].
Glutamin (asparagin)ase from Pseudomonas boreopolis 526 is shown to produce a cytotoxic effect on the human ovary carcinoma cells (CaOv line), Fisher lympholeukemia (L-8 line) and Burkitt's lymphoma cells (P3HR line). A significant inhibition of the DNA synthesis is found in L-8 and P3HR cell lines. The enzyme is less active in the cells of the CaOv line.
D000581:Amidohydrolases / Q000494:pharmacology*; D002051:Burkitt Lymphoma / Q000378:metabolism; D002478:Cells, Cultured; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D009369:Neoplasms / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000378:metabolism; D011549:Pseudomonas / Q000201:enzymology
D004273:DNA, Neoplasm; D000581:Amidohydrolases; C020654:glutamin-(asparagin-)ase
Deĭstvie preparatov glutamin[asparagin]azy iz mikroorganizmov na opukholevye kletki v kul'ture.