Effect of phencyclidine (PCP) on blood pressure and catecholamine levels in discrete brain nuclei.
PCP (10 mg/kg, s.c.) causes hypertension that is associated with decrease or tendency to decrease the levels of epinephrine and norepinephrine in the hypothalamus and the brainstem regions. If this represents a decreased catecholaminergic activity, then this may enhance sympathetic activity and contribute to the PCP-induced hypertension.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects*; D001933:Brain Stem / Q000032:analysis; D002395:Catecholamines / Q000032:analysis*; D002421:Caudate Nucleus / Q000032:analysis; D004298:Dopamine / Q000032:analysis; D004837:Epinephrine / Q000032:analysis; D005260:Female; D007031:Hypothalamus / Q000032:analysis; D009638:Norepinephrine / Q000032:analysis; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D002395:Catecholamines; D010622:Phencyclidine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine