Evaluation of habitual excessive alcohol consumption on myocardial infarction risk in coronary disease patients.
Overt coronary heart disease does occur at times in a setting of alcoholism. In an attempt to test the hypothesis that habitual excessive drinking may have an aggravating effect upon coexisting ischemic heart disease and may help precipitate new coronary events, we compared myocardial infarct prevalence among heavy drinkers and non-heavy drinkers with angiographically documented coronary artery disease. Infarct prevalence was found to be higher for heavy drinkers than for non-heavy drinkers under age 60 years, after controlling for differences in smoking habits and underlying atherosclerosis severity. A reversal in trend which may be due to the operation of selective factors causing premature coronary death among alcoholics was observed for individuals above age 60 years. These results, although open to differing interpretations, are consistent with the notion that heavy drinking has a destabilizing effect upon preexisting ischemic heart disease and may increase acute coronary event risk.
D000328:Adult; D000367:Age Factors; D000368:Aged; D000437:Alcoholism / Q000150:complications*; D003327:Coronary Disease / Q000150:complications* / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000150:complications; D008875:Middle Aged; D009203:Myocardial Infarction / Q000453:epidemiology / Q000209:etiology*; D012306:Risk; D012907:Smoking