title: The effects of capsaicin on the early outward current in identified snail neurones.
abstract: An investigation of the action of capsaicin (CAP) on the early outward current (IA) in identified neurones of Helix pomatia was performed using the single electrode clamp. CAP (60-300 microM) caused a dose-dependent reduction of the IA-currents in LPa3 and RPa3 neurones both in normal and Na-free solutions. There was also a marked shortening of the time constant for the inactivation of IA, and a 5-10 mV shift in the hyperpolarizing direction of the curve relating the steady-state inactivation of IA to membrane potential. The equilibrium potential for IA was not changed in up to 300 microM CAP solutions.
mesh_terms: D000818:Animals; D002211:Capsaicin / Q000494:pharmacology*; D006372:Helix, Snails; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
chemical_list: D002211:Capsaicin