title: Decidual changes in the endometrium and morphological adaptation of the associated supplying arteries in the normal and diabetic pseudopregnant rat.
abstract: After an electrically induced pseudopregnancy in rats in which deciduomas were produced by an intraluminal oil injection, the decidual tissue was studied morphologically on days 7, 10 and 13. A constant and dynamic wave of mitotic figures was found, which started on day 7 in the antimesometrial decidua, moving to the mesometrial decidua on day 10 and finally to the mesometrial triangle area on day 13 of pseudopregnancy. This and other morphological changes were compared with those found in pseudopregnant rats with streptozotocin-induced diabetes. On days 7 and 10 the incidence and distribution of mitotic figures were practically identical in both groups and statistically no significant difference was found in the uterine weight between the two groups on these two days. On day 13, two statistically significant differences were observed in the diabetic group: a fall in the uterine weight and a fall in the incidence of mitotic figures in the mesometrial triangle decidual cells. Associated with decidualization, a series of histological changes were studied in the arteries of the mesometrial triangle. Although the difference was not statistically significant, changes seemed to occur to a lesser degree in the diabetic group. It is concluded that the diabetic state has no influence in the early decidualization period, but it does have influence late in pseudopregnancy: a fall in the mitotic activity in the decidual tissue, a fall in the uterine weight and a less marked change in the spiral arteries which during pregnancy would supply the developing placenta with maternal blood.
mesh_terms: D000818:Animals; D003656:Decidua / Q000473:pathology*; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000473:pathology*; D004717:Endometrium / Q000473:pathology*; D005260:Female; D009929:Organ Size; D011555:Pseudopregnancy / Q000150:complications / Q000473:pathology*; D051381:Rats