Enhancement of the in vitro antibody response by thyrotropin.
The pituitary hormone thyrotropin (TSH) has been shown to enhance in a dose dependent manner the in vitro antibody response. Highly purified preparations of bovine and human TSH enhanced up to 375% the number of cells producing antibody to sheep erythrocytes. TSH had to be present prior to 24-48h of the initiation of culture for enhancement of the antibody response. An analogy is discussed between TSH and B lymphocyte growth and differentiation factors.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002417:Cattle; D004305:Dose-Response Relationship, Drug; D005260:Female; D007700:Kinetics; D051379:Mice; D008810:Mice, Inbred C57BL; D013045:Species Specificity; D013154:Spleen / Q000276:immunology; D013972:Thyrotropin / Q000494:pharmacology*
D013972:Thyrotropin