Autoradiographic demonstration of human 125I-interferon alpha in lysosomes of rabbit proximal tubule cells.
This investigation proves for the first time that by electron microscope autoradiography, 125I-interferon alpha can be located in the lysosomal system of the renal proximal tubule cells of the rabbit. The observation provides further evidence that the kidney has a major role in interferon catabolism.
D000818:Animals; D001345:Autoradiography; D007370:Interferon Type I / Q000032:analysis*; D007457:Iodine Radioisotopes; D007687:Kidney Tubules, Proximal / Q000648:ultrastructure*; D008247:Lysosomes / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D011817:Rabbits
D007370:Interferon Type I; D007457:Iodine Radioisotopes