A visual technique for the study of the pharmacological modification of polymorphonuclear chemotaxis.
The authors have shown the advantages of the necrotactic assay for the study of polymorphonuclear chemotactic responsiveness: observation of cellular behaviour during all the experiments, observation of a true chemotaxis and constant measure of cellular speed. Some examples of pharmacological treatment of the cells demonstrated the use of this technique for the study of modification of neutrophil chemotaxis by drugs.
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002470:Cell Survival; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D066298:In Vitro Techniques; D007705:Kinins / Q000494:pharmacology; D009504:Neutrophils / Q000502:physiology*; D051381:Rats
D000276:Adjuvants, Immunologic; D000893:Anti-Inflammatory Agents; D007705:Kinins