Spurious increase in serum creatinine associated with intravenous methyldopate therapy.
A patient with subarachnoid hemorrhage treated with intravenous methyldopate experienced a sudden marked increase in serum creatinine. This increase was due to interference by methyldopate in the assay for serum creatinine. By performing in vitro interference studies, we confirmed that methyldopate interferes with the creatinine assay.
D000368:Aged; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood*; D004573:Electrolytes / Q000097:blood; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008750:Methyldopa / Q000008:administration & dosage / Q000009:adverse effects*
D004573:Electrolytes; D008750:Methyldopa; D003404:Creatinine