Male sex hormone and nephropathy in Cohen diabetic rat. (Genetically selected sucrose fed).
In the Cohen diabetic rat (genetically-selected sucrose fed) ovariectomy caused a significant decrease in the incidence of nephropathy, from 52% in the unovariectomized, to 16% in the ovariectomized rat, [X2 (d.f. = 1) = 7.21905 P/0.01]. Testosterone administration to the ovariectomized diabetic animal resulted in a significantly increased incidence of nephropathy, from 16 to 92% [X2 (d.f. = 1) = 28.04427 P/0.01]. This change in incidence of nephropathy was directly correlated with a corresponding decrease or increase in the plasma oestradiol levels (in the ovariectomized and in the ovariectomized-testosterone treated diabetic animals, respectively). No such correlation was found with carbohydrate metabolism disturbances (as demonstrated by spontaneous blood glucose and spontaneous insulin) or with plasma testosterone levels.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D002369:Castration; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D003928:Diabetic Nephropathies / Q000209:etiology* / Q000473:pathology; D004958:Estradiol / Q000097:blood; D005260:Female; D005951:Glucose Tolerance Test; D007678:Kidney Glomerulus / Q000473:pathology; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D013739:Testosterone / Q000097:blood / Q000502:physiology*
D001786:Blood Glucose; D008055:Lipids; D013739:Testosterone; D004958:Estradiol