title: Cochlear deoxyglucose uptake: relationship to stimulus intensity.
abstract: The relationship between stimulus intensity and the uptake of 2-deoxyglucose (2-DG) in the cochlea of the gerbil was studied using an autoradiographic technique. In silence, incorporation of labeled 2-DG into stria vascularis and the spiral ligament was significantly higher than for other inner ear structures. With increasing intensity of noise exposure, 2-DG uptake in the spiral ganglion and VIIIth nerve increased dramatically when compared to the lateral wall structures. In contrast, relative 2-DG uptake in the organ of Corti was much less affected by noise exposure. Only at 105 dB SPL, the highest intensity tested, was a modest but statistically significant increase observed in the sensory epithelium. The small change in relative 2-DG uptake observed in the organ of Corti during acoustic stimulation is consistent with Davis' (1965: Quant. Biol. 30, 181-190) battery model of the cochlear transduction process. Alternatively, a larger change may have occurred, but been restricted to a small portion of the epithelium, such as one or both populations of hair cells.
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001345:Autoradiography; D002250:Carbon Radioisotopes; D003051:Cochlea / Q000378:metabolism*; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D005849:Gerbillinae; D009622:Noise; D009925:Organ of Corti / Q000378:metabolism; D013136:Spiral Ganglion / Q000378:metabolism; D013316:Stria Vascularis / Q000378:metabolism; D000159:Vestibulocochlear Nerve / Q000378:metabolism
chemical_list: D002250:Carbon Radioisotopes; D003837:Deoxy Sugars; D003847:Deoxyglucose