Peptide sweeteners. 7. Taste relationships of trifluoroacetyl-L-aspartylanilides.
A series of analogues of trifluoroacetyl-alpha-L-aspartylanilides substituted at various positions on the aromatic ring was synthesized and tasted. The position of the substitution is essential for the nature of the taste response. The results clearly establish the close relationship between sweet and bitter taste for these compounds. Combined electronic and topochemical contributions are discussed.
D000813:Anilides / Q000138:chemical synthesis*; D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D002855:Chromatography, Thin Layer; D006801:Humans; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009904:Optical Rotation; D013329:Structure-Activity Relationship; D013549:Sweetening Agents / Q000138:chemical synthesis*; D013649:Taste
D000813:Anilides; D007202:Indicators and Reagents; D013549:Sweetening Agents; D001224:Aspartic Acid