Stereoselective binding of propranolol enantiomers to human alpha 1-acid glycoprotein and human plasma.
The binding of propranolol enantiomers to human albumin (ALB), alpha 1-acid glycoprotein (alpha 1-AGP) and plasma was studied. (-) propranolol is more bound than (+)propranolol to alpha 1-AGP (P less than 0.001) and to plasma (P less than 0.05). In solutions containing ALB at a constant concentration (580 mumol/l) and alpha 1-AGP at increasing concentrations, the binding of both isomers increases but the stereo selectivity is evident throughout the alpha 1-AGP concentration range examined (25-100 mumol/l).
D000328:Adult; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D009961:Orosomucoid / Q000378:metabolism*; D011433:Propranolol / Q000097:blood*; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism*; D013237:Stereoisomerism
D009961:Orosomucoid; D012709:Serum Albumin; D011433:Propranolol