[Modification of selected leukocyte functions in albino rats caused by the transplantable Jensen sarcoma and by therapeutic trials of cyclophosphamide and vinblastine, Clostridium butyricum M55 and short-term hyperglycemia].
A significant increase in leukocyte adhesion and agglomeration was observed in white rats with Jensen sarcoma. Glucose induced short-term hyperglycemia temporarily stimulated these leukocyte functions in healthy rats. This effect was not notably influenced by administration of tumorlyzing spores. In contrast administration of the cytostatic agents vinblastine and cyclophosphamide demonstrated dose-related inhibition of leukocyte agglomeration and adhesion.
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002449:Cell Aggregation / Q000187:drug effects; D003013:Clostridium; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use*; D006943:Hyperglycemia / Q000097:blood*; D007962:Leukocytes / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D012513:Sarcoma, Experimental / Q000097:blood* / Q000628:therapy; D013997:Time Factors; D014747:Vinblastine / Q000627:therapeutic use*
D014747:Vinblastine; D003520:Cyclophosphamide
Beeinflussung ausgewählter Leukozytenfunktionen der weissen Ratte durch den Transplantationstumor "Jensen-Sarkom" sowie onkologische Therapieversuche mit Cyclophosphamid und Vinblastin, Clostridium butyricum M 55 und artefizieller Kurzzeithyperglykämie.