title: Physiological circulating levels of secretin-like immunoreactivity in the human do not stimulate free fatty acid production.
abstract: An in vivo study was carried out to establish whether infused secretin, which achieves physiological levels of secretin-like immunoreactivity (SLI), promotes lipolysis. Six healthy volunteers received two infusions after separate 8 h overnight fasts. The paired infusions of either 500 ml of normal saline or 150 C.U. of porcine secretin in 500 ml of normal saline were infused at a constant rate of 1.38 ml/min. Venous blood was sampled at 0, 1, 2, 3, 4, 5 and 6 h after the infusion started. Mean plasma concentrations of SLI were significantly higher after infusion of saline with secretin in comparison to infusion of saline alone but remained within the physiological range. Mean serum free fatty acid (FFA) and 3-hydroxybutyrate concentrations rose significantly with time during both infusions but the mean FFA and 3-hydroxybutyrate concentrations did not differ significantly between infusions at each time of assessment. We conclude that a lipolytic role for secretin has not been shown to be of importance in relation to the in vivo rise in FFA concentrations observed in the fasting normal subject.
mesh_terms: D020155:3-Hydroxybutyric Acid; D000328:Adult; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D012633:Secretin / Q000097:blood* / Q000276:immunology / Q000494:pharmacology
chemical_list: D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D012633:Secretin; D020155:3-Hydroxybutyric Acid