Fructose-1,6-diphosphate counteracts potassium effects on cardiac muscle.
Fructose-1,6-diphosphate (FDP) counteracts the inhibition of contractile strength of rabbit cardiac muscle induced by KCl "in vitro" and the valinomycin induced depolarization. FDP also protects in a dose-dependent fashion, up to 100 mg/kg, different strains of mice from the lethal effect of KCl that is due to a complete atrio-ventricular block and related to a high value of plasma potassium level. A protective effect of FDP is observed when increasing doses of (+/-) propranolol are injected before maximum non lethal dose of KCl.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D005635:Fructosediphosphates / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006598:Hexosediphosphates / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009200:Myocardial Contraction / Q000187:drug effects; D011188:Potassium / Q000037:antagonists & inhibitors*; D011189:Potassium Chloride / Q000037:antagonists & inhibitors / Q000633:toxicity; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D013050:Spectrometry, Fluorescence; D014634:Valinomycin / Q000494:pharmacology
D005635:Fructosediphosphates; D006598:Hexosediphosphates; D014634:Valinomycin; D011189:Potassium Chloride; D011433:Propranolol; C029063:fructose-1,6-diphosphate; D011188:Potassium