[Effect of bulbar microinjections of noradrenaline, isoproterenol and phentolamine on the spino-bulbo-spinal reflex in the cat].
In chloralose-anesthetized cats a long lasting depression of spino-bulbo-spinal (SBS) reflex discharges following microinjections of noradrenaline and its agonist (isoproterenol) in the medial bulbar reticular formation was revealed. Microinjections of phentolamine (alpha-adrenoceptor antagonist) were followed by prominent enhancement of SBS-reflexes. Depressive action of the locus coeruleus stimulation on SBS-responses essentially decreased after these microinjections. The data evidence for a specific noradrenergic nature of inhibitory locus coeruleus influences on reticular centre of SBS-reflexes.
D000818:Animals; D002415:Cats; D003655:Decerebrate State / Q000503:physiopathology; D007545:Isoproterenol / Q000494:pharmacology*; D008125:Locus Coeruleus / Q000502:physiology; D008845:Microinjections; D009434:Neural Pathways / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology*; D010646:Phentolamine / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects*; D012154:Reticular Formation / Q000187:drug effects*; D013116:Spinal Cord / Q000187:drug effects*
D007545:Isoproterenol; D009638:Norepinephrine; D010646:Phentolamine
Vliianie bul'barnykh mikroin"ektsiĭ noradrenalina, izoproterenola i fentolamina na spino-bul'bo-spinal'nyĭ refleks u koshki.