The effect of 3-methyl substitution on the carcinogenicity of nitroso-4-piperidone.
The carcinogenic activity of the 3-methyl derivative of nitroso-4-piperidone was compared with that of the compound without the methyl group, by chronic administration to rats at equimolar doses in drinking water. Nitrosopiperidone induced both liver and esophageal tumors, whereas the 3-methyl derivative induced only tumors of the esophagus in a much shorter time.
D000818:Animals; D002273:Carcinogens; D004938:Esophageal Neoplasms / Q000139:chemically induced; D005260:Female; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008968:Molecular Conformation; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009602:Nitrosamines / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D013329:Structure-Activity Relationship
D002273:Carcinogens; D009602:Nitrosamines; C043305:1-nitroso-4-piperidone; C043306:1-nitroso-3-methyl-4-piperidone