Effect of serotonin on albumin and low density lipoprotein uptake in perfused rabbit femoral arteries.
Uptake by the arterial wall of plasma constituents has considerable clinical implication; thus, uptake of low density lipoprotein (LDL) plays an important role in the development of atherosclerosis. Serotonin and other vasoactive material may result in changes in the arterial wall leading to increased uptake of albumin or low density lipoprotein. This study was conducted to determine the effect of serotonin (10(-5)M 5-hydroxytryptamine) and serotonin-induced arterial constriction on albumin and low density lipoprotein uptake rates in perfused rabbit femoral arteries. The results show that the presence of serotonin inhibits the rate of uptake of both albumin and LDL. The effect on albumin uptake does not have a direct dose response dependence and is linearly dependent on transmural pressure. In contrast, LDL uptake rates are only slightly affected by pressure. Thus, albumin and LDL uptake processes appear to be due to separate mechanisms.
D000818:Animals; D001794:Blood Pressure; D005263:Femoral Artery / Q000187:drug effects* / Q000378:metabolism; D007457:Iodine Radioisotopes; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D011817:Rabbits; D012701:Serotonin / Q000494:pharmacology*; D012709:Serum Albumin / Q000378:metabolism*; D013223:Statistics as Topic
D007457:Iodine Radioisotopes; D008077:Lipoproteins, LDL; D012709:Serum Albumin; D012701:Serotonin