Nephrectomy enhances alcohol-induced hypoglycemia in fasted rats.
Male Wistar rats (N = 84) weighing 230-270 g were fasted 48 hr. Equal groups were controls, nephrectomized bilaterally and sham-operated. Equal subgroups were then given 4.0, 6.0 or 7.5 g of alcohol per kg of body weight or water by orogastric intubation. Blood glucose levels did not decrease significantly after nephrectomy alone or after the 4.0 g/kg dose. Blood glucose declined significantly more in the nephrectomized than in the sham-operated rats at 90 and 180 min after the 6.0 g/kg dose. Blood glucose decreased significantly in both the nephrectomized and sham-operated rats after the 7.5 g/kg dose.
D000428:Alcohol Drinking; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D005215:Fasting; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose