[Effect of adrenaline on kidney lysosome function in rats during prolonged soft tissue crushing].
The total and unsedimentable activity of acid DNase, RNase, phosphatase and arylsulfatases A and B was examined in the rat kidneys during long-term compression of soft tissues in the presence of high excitability of the sympathoadrenal system. Injection of adrenalin to rats with trauma reduced the total activity of DNase, acid phosphatase and arylsulfatases A and B, particularly at the late periods of soft tissue compression, whereas the total activity of acid RNase slightly increased as compared with control. Compression of soft tissues after adrenalin preinjection was accompanied by a substantial rise of unsedimentable activity of the lysosomal enzymes under study in the kidneys. The activity of the enzymes in cytosol progressively ascended as the time of soft tissue injury increased.
D000818:Animals; D003444:Crush Syndrome / Q000201:enzymology*; D004837:Epinephrine / Q000494:pharmacology*; D006867:Hydrolases / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051381:Rats; D012774:Shock, Traumatic / Q000201:enzymology*; D013997:Time Factors
D006867:Hydrolases; D004837:Epinephrine
Vliianie adrenalina na funktsional'noe sostoianie lizosom pochek krys pri dlitel'nom sdavlenii miagkikh tkaneĭ.