Inhibition by heparin of platelet accumulation in vivo.
In vivo platelet aggregation has been studied using a novel, minimally invasive technique. No aggregatory effects of heparin were observed on normal circulating platelets nor was there enhancement of aggregation of platelets during activation by intravenous injection of ADP, collagen, PAF acether or thrombin. On the contrary, high doses of heparin were found to inhibit platelet accumulation induced by ADP, collagen or PAF-acether. Inhibition of these responses necessitated doses of heparin in excess of those required for anti-coagulant effects. The present experiments do not establish a mechanism for such inhibition. Extension to other species, including man, is needed before attributing clinical relevance to the present observations.
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D002860:Chromium Radioisotopes; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006493:Heparin / Q000494:pharmacology*; D007700:Kinetics; D010974:Platelet Aggregation / Q000187:drug effects*; D010976:Platelet Count; D014859:Warfarin / Q000494:pharmacology
D002860:Chromium Radioisotopes; D014859:Warfarin; D006493:Heparin