The two apolipoprotein loci apo A-I and apo A-IV are closely linked in man.
In man the closely linked genes for the apolipoproteins A-I and C-III have been assigned to chromosome 11. Linkage studies performed in a Norwegian family with a mutant apoA-I gene established a close linkage between the loci for apoA-I and apoA-IV. For both sexes combined, the peak lod score was 3.01 at a recombination fraction of 0 = 0.00. Thus this study adds the locus of apoA-IV to the previously reported apolipoprotein gene cluster on chromosome 11. The previously unidentified polymorphic serum protein, USP1, is by immunochemical and electrophoretical methods identified as apoA-IV. ApoA-IV typing should be a valuable tool in elucidating the genomic organization of chromosome 11.
D001054:Apolipoproteins A / Q000235:genetics*; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D007526:Isoelectric Point; D008297:Male; D008970:Molecular Weight; D010375:Pedigree
D001054:Apolipoproteins A