Biological activity of new phosphorylated analogues of oxotremorine.
A number of N-4 (4-dialkylamino-2-butynyl) phosphoramide derivatives related to the oxotremorine structure were prepared and evaluated for their muscarinic activity on isolated perfused rat hearts. A structure-activity relationship study revealed that among other factors, muscarinic activity is directly related to the environment of the phosphorus atom.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002800:Cholinesterase Inhibitors; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects; D010095:Oxotremorine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010477:Perfusion; D010766:Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000187:drug effects; D013329:Structure-Activity Relationship
D002800:Cholinesterase Inhibitors; D011976:Receptors, Muscarinic; D010095:Oxotremorine