title: Drug-induced modulation of locomotor hyperactivity induced by picrotoxin in nucleus accumbens.
abstract: Locomotor hyperactivity was induced in rats by bilateral injection of picrotoxin (PIC) into the nucleus accumbens (NAC) followed by intraperitoneal (IP) or intra-accumbens (IA) injection of agents affecting dopamine (DA), acetylcholine, serotonin, or GABA receptors. IP injection of haloperidol and diazepam attenuated PIC-induced hypermotility in a dose-dependent manner. Low (sedative) doses of the DA agonists apomorphine (APO) and lisuride, or pretreatment with reserpine abolished PIC-induced hypermotility. Independent of a preceding IA injection of PIC, higher IP doses of APO produced the well-known locomotor effect. LSD, and the atypical neuroleptic, sulpiride, potentiated PIC-induced hypermotility strongly whereas clozapine was ineffective. IA injection of carbachol or haloperidol, in doses which antagonized hypermotility induced by APO IP, did not influence PIC-induced hypermotility. The atypical neuroleptics, clozapine and sulpiride, and the benzodiazepine, diazepam, inhibited PIC-induced hypermotility. The results suggest that there is a complex involvement of GABA, DA and serotonin functions in the effectuation of PIC-induced hypermotility and that PIC-induced hypermotility may be affected by DA-sensitive structures situated outside the NAC.
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D003024:Clozapine / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D008090:Lisuride / Q000494:pharmacology; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology*; D010852:Picrotoxin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D012686:Septal Nuclei / Q000502:physiology*; D013469:Sulpiride / Q000494:pharmacology
chemical_list: D001058:Apomorphine; D002217:Carbachol; D003024:Clozapine; D003975:Diazepam; D006220:Haloperidol; D008090:Lisuride; D008238:Lysergic Acid Diethylamide; D010852:Picrotoxin; D012110:Reserpine; D013469:Sulpiride