title: Sinoaortic baroreceptors and the control of blood volume in the nonhuman primate.
abstract: The purpose of this study was to determine the role of the aortic and carotid baroreceptors in regulating blood volume in the conscious non-human primate. Eighteen control animals were surgically instrumented to permit the recording of blood pressure, pulse rate, and left atrial pressure. After a urethral catheter was inserted into the bladder, the animals were given an intravenous infusion equal to 20% of the estimated blood volume. Renal function was determined before and after the volume expansion. Nine monkeys received the same infusion after undergoing chronic sinoaortic denervation. The denervated animals responded with a potentiated diuresis and natriuresis. The control animals excreted 24% of the infused volume and 4% of the infused salt while the sinoaortic-denervated animals excreted a volume equal to 113% of that infused and an amount of sodium equal to 46% of that infused. We conclude that high-pressure receptors exert an inhibitory influence on whatever mechanisms are involved in the renal response to acute volume expansion.
mesh_terms: D000818:Animals; D001011:Aorta / Q000502:physiology*; D001794:Blood Pressure; D001810:Blood Volume; D002346:Carotid Sinus / Q000502:physiology*; D003404:Creatinine / Q000378:metabolism; D006339:Heart Rate; D008252:Macaca fascicularis; D008253:Macaca mulatta; D009994:Osmolar Concentration; D010215:Papio; D011188:Potassium / Q000378:metabolism; D011311:Pressoreceptors / Q000502:physiology*; D012964:Sodium / Q000378:metabolism; D014556:Urine
chemical_list: D012964:Sodium; D003404:Creatinine; D011188:Potassium