title: Total chemical synthesis and antitumor evaluation of 4-demethoxy-10,10-dimethyldaunomycin.
abstract: The novel anthracycline analogue 4-demethoxy-10,10-dimethyldaunomycin was prepared in nine chemical steps from 5,8-dimethoxy-2-tetralone. It proved to be inactive as an antitumor agent in the mouse P388 lymphocytic leukemia model.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000633:toxicity; D004317:Doxorubicin / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D015255:Idarubicin / Q000031:analogs & derivatives*; D007202:Indicators and Reagents; D007941:Leukemia P388 / Q000188:drug therapy; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D008811:Mice, Inbred DBA
chemical_list: D000970:Antineoplastic Agents; D007202:Indicators and Reagents; D004317:Doxorubicin; C042926:4-demethoxy-10,10-dimethyldaunomycin; D015255:Idarubicin; D003630:Daunorubicin