[The evaluation of non-isothermal short-term tests of drug solutions].
Non-isothermal short-term tests to examine the stability of drug solutions, are critically discussed with regard to their application to simple and complex reaction mechanisms. The influence of additional temperature dependences (ionic product of water, activity coefficient) is assayed. By example of the decomposition of tetracaine hydrochloride and acetylsalicylic acid, the evaluation of experimental results is discussed considering these factors.
D001241:Aspirin / Q000032:analysis; D002021:Buffers; D002384:Catalysis; D002626:Chemistry, Pharmaceutical / Q000379:methods; D002849:Chromatography, Gas; D004355:Drug Stability; D005069:Evaluation Studies as Topic; D004364:Pharmaceutical Preparations / Q000032:analysis*; D013696:Temperature; D013748:Tetracaine / Q000032:analysis; D013816:Thermodynamics; D013997:Time Factors
D002021:Buffers; D004364:Pharmaceutical Preparations; D013748:Tetracaine; D001241:Aspirin
Zur Auswertung nichtisothermer Kurzzeittests von Arzneistofflösungen.