Gentamicin diffusion across hydrogel bandage lenses and its kinetic distribution on the eye.
Soft contact lenses have been used as therapeutic bandages to aid epithelial healing following pentrating keratoplasty. Often the hydrogel lenses are used in conjunction with topical medications such as gentamicin. A reported complication is the persistence of infectious ulcers even though the eye is being treated with topical antibiotics. The purpose of this study was to measure the gentamicin diffusion coefficients for some hydrogel bandage lenses and to design a kinetic model to estimate the drug distribution on an eye covered with a hydrogel contact lens. The model includes the hydrogel diffusion coefficients and literature values for tear production, tear exchange per blink around the edge of a lens, fit, etc. From the computer generated data, it can be shown that the permeability of gentamicin sulfate through the Saulfon-80 hydrogel lens on a normal eye was only 0.002% of the amount of the drug under the contact lens after 10 minute intervals of topical drug application. The important drug distribution pathway was around the edge of the lens.
D001682:Biological Availability; D001692:Biological Transport; D003263:Contact Lenses, Hydrophilic; D003315:Cornea / Q000378:metabolism* / Q000601:surgery; D004058:Diffusion; D005839:Gentamicins / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D009883:Ophthalmic Solutions; D011182:Postoperative Care; D013499:Surface Properties; D013666:Tears / Q000502:physiology; D014945:Wound Healing / Q000187:drug effects
D005839:Gentamicins; D009883:Ophthalmic Solutions