Beneficial effect of cyclosporin A on the lymphocytic choriomeningitis virus infection in mice.
The effect of cyclosporin A on the course of lymphocytic choriomeningitis virus infection in mice was investigated. Evidence is presented that administration of this immunosuppressive drug spares a majority of lethally infected mice. This beneficial effect is different from the one obtained with other treatments leading to the abolition of T cell functions. Surviving animals rapidly eliminate the virus and produce high titers of neutralizing IgG antibodies.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D003524:Cyclosporins / Q000627:therapeutic use*; D005260:Female; D007668:Kidney / Q000382:microbiology; D008216:Lymphocytic Choriomeningitis / Q000188:drug therapy*; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology / Q000302:isolation & purification; D051379:Mice; D008809:Mice, Inbred C3H; D013045:Species Specificity
D000914:Antibodies, Viral; D003524:Cyclosporins