[Role of prostaglandins in the pathogenesis of bronchial asthma in children and possibilities in therapeutic treatment].
During the past few years, in relation to study of prostaglandins, biochemical active lipids recently identified, a large quantity of physiological and pathological processes involving these compounds have been described. Convincing data confirm the regulation of the tone of smooth trachea and bronchial muscles by these substances. In this sense and within the pathological states of the respiratory system, bronchial asthma is of special interest. Recently, a detailed description of the pathogenesis of bronchial asthma, and particularly of this atypical form, has been investigated. Classic mediators of anaphylaxis, such as histamin, SRS-A, serotonin, acetylcholin, etc., have important roles in the pathogeny. Fewer works, however, have been dedicated to the study of prostaglandins and the results obtained are often contradictory. In this study, the importance of prostaglandins E, F-2 alpha, A and B are investigated in 84 patients with a diagnosis of bronchial asthma. Their ages varies between 2 and 11 years. 51 suffered from the atypical form, 11 from infectious form and 22 the mixed form. To diagnose each case, detailed anamnesis and clinical tests were carried out as well as cutaneous tests with non bacterial and fungous allergens. The RAST technique and total levels of IgE were also used. The control group of 45 children were studied in the same way. With regard to the results obtained, during the intercrisis period a rise in PGF2-alpha and a decrease in PGE could be observed. During the crisis period, an even greater rise in the concentration of PGF2-alpha and a lesser of increase of PGE were observed.(ABSTRACT TRUNCATED AT 250 WORDS)
D000628:Aminophylline / Q000494:pharmacology / Q000627:therapeutic use; D001249:Asthma / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D001980:Bronchi / Q000503:physiopathology; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006911:Hydroxyprostaglandin Dehydrogenases / Q000037:antagonists & inhibitors; D011453:Prostaglandins / Q000097:blood / Q000378:metabolism / Q000502:physiology*
D001993:Bronchodilator Agents; D011453:Prostaglandins; D000628:Aminophylline; D006911:Hydroxyprostaglandin Dehydrogenases; C035858:prostaglandin-E2 9-reductase
Papel de las prostaglandinas en la patogenia del asma bronquial en los niños y posibilidades en el tratamiento terapéutico.