[Use of antioxidants for preventing the hepatotoxic effect of acrylonitrile].
The authors examined the possibility of using antiooxidants in the chemoprophylaxis of poisonings with alkylating chemical compounds. It was demonstrated that vitamin E, ionol and low-molecular thiols (cystein, glutatione and unithiol) prevent the increased permeability of plasma membranes and impairment of the protein-synthesizing function of the endoplasmic reticulum of hepatoytes in acute and chronic acrylonitrile poisoning.
D000181:Acrylonitrile / Q000506:poisoning* / Q000633:toxicity; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002091:Butyrylcholinesterase / Q000097:blood; D004353:Drug Evaluation, Preclinical; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009570:Nitriles / Q000506:poisoning*; D051381:Rats; D013997:Time Factors
D000975:Antioxidants; D009570:Nitriles; D002091:Butyrylcholinesterase; D005634:Fructose-Bisphosphate Aldolase; D000181:Acrylonitrile
Ispol'zovanie antioksidantov dlia preduprezhdeniia gepatotoksicheskogo éffekta akrilonitrila.