Cholinergic receptor binding in the frontal cortex of suicide victims.
Muscarinic binding sites were assessed in the frontal cortex of 22 suicide victims and 22 control subjects. There were no significant differences between the two groups in either the number of binding sites (Bmax) or their relative affinity (Kd). The results of this study are discussed in reference to the cholinergic hypothesis of affective disorders.
D000293:Adolescent; D000328:Adult; D000368:Aged; D003866:Depressive Disorder / Q000378:metabolism; D005260:Female; D005625:Frontal Lobe / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D011813:Quinuclidinyl Benzilate / Q000032:analysis / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000032:analysis* / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000032:analysis / Q000378:metabolism; D013405:Suicide
D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D011813:Quinuclidinyl Benzilate