Pharmacokinetics in baclofen overdose.
The pharmacokinetics of baclofen analyzed by gas chromatography mass spectrometry in a massive intoxication case (baclofen 1230 mg orally) is presented. In contrast to earlier reports, no increase in the plasma half-life of elimination of baclofen could be observed (t1/2 = 4.58 hours). On the contrary, we found an increased plasma clearance (Clpl = 0.368 l/kg) in this highly intoxicated patient compared to the kinetics usually found in healthy subjects.
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D001418:Baclofen / Q000097:blood / Q000378:metabolism* / Q000506:poisoning / Q000652:urine; D001784:Blood Gas Analysis; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D019966:Substance-Related Disorders; D013406:Suicide, Attempted; D007507:Therapeutic Irrigation
D001418:Baclofen