title: Caenorhabditis elegans and Panagrellus redivivus: enzyme-mediated modification of chemotaxis.
abstract: Treatment with mannosidase or sialidase completely inhibited chemotactic responses of Caenorhabditis elegans wild type, C. elegans mutants CB1377 (daf-6)X and CB1379 (che-3)I, and Panagrellus redivivus to a source of attractants. Trypsin (EC3.4.21.4) caused a partial reduction in the level of chemoresponse. Normal chemotaxis was renewed within 20 hr following exposure to the enzymes. Other enzymes tested had no effect. Experimental and supporting evidence is presented that behavioral modification resulted from functional impairments to receptors located within chemosensory sensilla.
mesh_terms: D000818:Animals; D002107:Caenorhabditis / Q000187:drug effects / Q000502:physiology*; D002628:Chemoreceptor Cells / Q000032:analysis / Q000502:physiology*; D002633:Chemotaxis / Q000187:drug effects*; D006867:Hydrolases / Q000494:pharmacology*; D008361:Mannosidases / Q000494:pharmacology; D008954:Models, Biological; D009068:Movement / Q000187:drug effects; D009348:Nematoda / Q000187:drug effects / Q000502:physiology*; D009439:Neuraminidase / Q000494:pharmacology; D014357:Trypsin / Q000494:pharmacology
chemical_list: D006867:Hydrolases; D008361:Mannosidases; D009439:Neuraminidase; D014357:Trypsin