The effects of aminopyridines on the cortical evoked potentials.
The effects of 3-AP, 4-AP and 3,4-DAP were studied on auditory and somatosensory evoked potentials of the cat. Particular attention was paid to differentiation between the effects exerted in the pre-convulsive and convulsive phase of AP action. Surface recording and depth analysis were carried out with simultaneous surface-depth records presented in case of 3,4-DAP. All three APs exerted a general depressant action on the evoked potentials in the preconvulsive phase. The most sensitive to depression proved to be the surface negative wave. In the ictal periods of the convulsive phase the potentials were strongly facilitated and broadened. In subsequent periods of the convulsive phase the surface records became similar to the deep ones, as a consequence of depression of the surface positive and enhancement of the surface negative wave. In interictal periods the depression remained dominant.
D015761:4-Aminopyridine; D000077770:Amifampridine; D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects; D005260:Female; D008297:Male; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology
D000631:Aminopyridines; C031283:3-aminopyridine; D015761:4-Aminopyridine; D000077770:Amifampridine