title: Quantitation of excretion of dolichol and dolichyl phosphate from the rat.
abstract: In order to gain information on the metabolism of dolichol, the rates of excretion of dolichol and dolichyl phosphate were determined in rats maintained on a dolichol-free diet for 10 days. Analysis of fecal samples collected every 48 h yielded mean output values of 9.0 +/- 1.4 and 20.7 +/- 3.0 micrograms/rat/day of dolichol and dolichyl phosphate, respectively. Urinary output rates were 0.56 +/- 0.12 and 0.50 +/- 0.28 microgram/rat/day of dolichol and dolichyl phosphate, respectively. Thus, excretion is one fate of endogenously synthesized dolichol compounds in the rat.
mesh_terms: D000818:Animals; D001835:Body Weight; D002851:Chromatography, High Pressure Liquid; D004224:Diterpenes / Q000378:metabolism*; D004288:Dolichol Phosphates / Q000378:metabolism* / Q000652:urine; D004286:Dolichols / Q000172:deficiency / Q000378:metabolism* / Q000652:urine; D005243:Feces / Q000032:analysis; D008099:Liver / Q000378:metabolism; D008297:Male; D011106:Polyisoprenyl Phosphates / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014316:Tritium
chemical_list: D004224:Diterpenes; D004288:Dolichol Phosphates; D004286:Dolichols; D011106:Polyisoprenyl Phosphates; D014316:Tritium