Estrogen-like effects of combined dexamethasone and tamoxifen in the chick oviduct.
The effects of dexamethasone alone on withdrawn chick oviduct weight, DNA, protein content and progesterone receptor concentration were barely detectable, whereas ovalbumin and conalbumin synthesis were increased. When dexamethasone and tamoxifen were combined, a marked increase of total proteins, including egg white proteins, DNA and wet weight occurred. Progesterone receptor also was increased. The most striking result was the stimulation of DNA polymerase-alpha activity by combined dexamethasone and tamoxifen, whereas either compound was completely ineffective.
D000818:Animals; D002645:Chickens; D004247:DNA / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology*; D004347:Drug Interactions; D004967:Estrogens; D005260:Female; D007700:Kinetics; D009929:Organ Size / Q000187:drug effects; D010057:Oviducts / Q000187:drug effects / Q000502:physiology*; D011506:Proteins / Q000378:metabolism; D011980:Receptors, Progesterone / Q000187:drug effects / Q000378:metabolism; D013629:Tamoxifen / Q000494:pharmacology*
D004967:Estrogens; D011506:Proteins; D011980:Receptors, Progesterone; D013629:Tamoxifen; D003907:Dexamethasone; D004247:DNA