Effects of histamine inhalation and airway vibration on phrenic nerve activity in rabbits.
Experiments were performed on 8 rabbits under urethane-chloralose anesthesia. Histamine aerosol (5%) administered into the trachea by a cannula produced tonic activity of the phrenic nerve, with discharges also being evident during the expiratory phase. Airway vibration (100 Hz) inhibited this tonic activity and caused silence during the expiratory phase.
D000222:Adaptation, Physiological; D000818:Animals; D006632:Histamine / Q000494:pharmacology*; D008465:Mechanoreceptors / Q000187:drug effects; D010791:Phrenic Nerve / Q000187:drug effects*; D011817:Rabbits; D012119:Respiration / Q000187:drug effects; D012137:Respiratory System / Q000294:innervation; D014732:Vibration
D006632:Histamine