Amiodarone-induced pulmonary toxicity.
Amiodarone hydrochloride, an investigational drug used to suppress ventricular arrhythmias, may cause pulmonary toxicity with associated radiographic abnormalities. Two patients are presented who illustrate the variability of these abnormalities. One of these patients died of respiratory failure while the other recovered after amiodarone was stopped and corticosteroid therapy was started.
D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D001344:Autopsy; D001572:Benzofurans / Q000009:adverse effects*; D001706:Biopsy; D005500:Follow-Up Studies; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D008168:Lung / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000000981:diagnostic imaging* / Q000188:drug therapy; D011859:Radiography
D001572:Benzofurans; D005938:Glucocorticoids; D000638:Amiodarone