title: [Action of reumycin on the blood system in an experiment].
abstract: The effect of reumycin, an antitumor antibiotic on the peripheral circulatory system and bone marrow was studied on albino rats. The drug was injected intraperitoneally in a dose of 25 mg/kg daily for 30 days. It was shown that reumycin had a comparatively low toxic effect on the peripheral circulatory system and hemopoiesis. It induced the signs of transitory anemia and did not suppress the regenerative capacity of the bone marrow. After the drug repeated use there was an increase in the platelet count and in the rate of blood coagulation. These signs vanished a month after the end of the treatment course.
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001769:Blood / Q000187:drug effects*; D001772:Blood Cell Count; D001773:Blood Cells / Q000187:drug effects*; D001853:Bone Marrow / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006410:Hematopoiesis / Q000187:drug effects; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014227:Triazines / Q000494:pharmacology
chemical_list: D000903:Antibiotics, Antineoplastic; D011743:Pyrimidines; D014227:Triazines; C009169:reumycin
vernacular_title: Deĭstvie reumitsina na sistemu krovi v éksperimente.