Protective effect of butylated hydroxytoluene on adriamycin-induced skin necrosis in the rat.
The effect of butylated hydroxytoluene (BHT) on adriamycin (ADR)-induced skin ulcers was investigated using rats. The application of BHT reduced the size of the skin ulcers by the following amounts: topical application (20%); intradermal injection (50%); repeated applications of BHT (82%). Additional studies are required to determine if BHT will be a modifier of ADR extravasation in cancer patients.
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D004317:Doxorubicin / Q000633:toxicity*; D008297:Male; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains; D012883:Skin Ulcer / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*
D002084:Butylated Hydroxytoluene; D004317:Doxorubicin