The sensitizing capacity of atranorin.
The allergenic potential of the aromatic lichen substance atranorin has been investigated by means of the guinea pig maximization test of Magnusson & Kligman. Sensitivity was induced in 30% of the animals, which corresponds to a moderate allergenic capacity (grade III). This is in agreement with the clinically-observed frequency of 1.5% among our patients. A modified photoallergy test on the same animals was performed, but irradiation did not increase the number of positive reactions. 4 patients with proven contact sensitivity to atranorin, evernic, usnic or physodic acid, were examined with different dilutions from 0.001 to 0.1%. Irradiation of the test series did not provoke any clear-cut photoallergic reaction.
D000328:Adult; D000368:Aged; D000818:Animals; D003877:Dermatitis, Contact / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D062385:Hydroxybenzoates / Q000009:adverse effects* / Q000276:immunology; D008011:Lichens / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000175:diagnosis; D010936:Plant Extracts / Q000276:immunology
D062385:Hydroxybenzoates; D010936:Plant Extracts; C026304:atranorin