title: Mesophase formation during cholesterol gallstone dissolution in human bile: effect of bile acid composition.
abstract: Duodenal bile obtained from patients with gallstones who were acutely infused with chenodeoxycholic acid, ursodeoxycholic acid, or cholic acid were examined for the propensity toward the formation of a liquid crystalline mesomorphic phase when cholesterol gallstones were incubated in these bile acids. Bile taken from patients infused with ursodeoxycholic acid was found to be enriched in ursodeoxycholic acid; mesophase formation was detected in these samples but not in bile from patients infused with chenodeoxycholic acid or cholic acid.
mesh_terms: D001646:Bile / Q000032:analysis*; D001647:Bile Acids and Salts / Q000032:analysis*; D002635:Chenodeoxycholic Acid / Q000032:analysis; D002769:Cholelithiasis / Q000378:metabolism*; D002784:Cholesterol / Q000032:analysis; D019826:Cholic Acid; D002793:Cholic Acids / Q000032:analysis; D004386:Duodenum; D006801:Humans; D008095:Lithocholic Acid; D010743:Phospholipids / Q000032:analysis; D012995:Solubility; D013997:Time Factors; D014580:Ursodeoxycholic Acid / Q000032:analysis
chemical_list: D001647:Bile Acids and Salts; D002793:Cholic Acids; D010743:Phospholipids; D002635:Chenodeoxycholic Acid; D008095:Lithocholic Acid; D014580:Ursodeoxycholic Acid; D002784:Cholesterol; D019826:Cholic Acid