5-hydroxytryptamine injected intraventricularly fails to influence the brain water content.
Measurement of the content of brain water and electrolytes after the intraventricular administration of 5-hydroxytryptamine in rats, with and without exposure to osmotic stress, failed to show water accumulation in the brain parenchyma. It is suggested that elevation of serotonin in the cerebrospinal fluid--resembling pathological situations such as subarachnoid hemorrhage--does not play a primary role in brain edema formation.
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D001834:Body Water / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D001923:Brain Chemistry; D001929:Brain Edema / Q000139:chemically induced*; D005260:Female; D007276:Injections, Intraventricular; D008297:Male; D009994:Osmolar Concentration; D009997:Osmotic Pressure; D051381:Rats; D012701:Serotonin / Q000008:administration & dosage / Q000134:cerebrospinal fluid / Q000633:toxicity*; D014882:Water-Electrolyte Balance
D012701:Serotonin