Lack of effect of influenza and pneumococcal vaccines on anticoagulation by warfarin.
The effects on anticoagulation of a purified trivalent sub-unit influenza vaccine and a 14-valent pneumococcal vaccine were investigated in a single-blind controlled study involving 69 well-stabilised warfarin recipients. There were no clinically or statistically significant alterations of anticoagulant control in vaccine recipients as compared with controls at 2, 7 and 21 days after vaccination. On the basis of these data, concern about warfarin-vaccine interaction should not deter practitioners from immunising warfarin recipients against influenza or infection with Streptococcus pneumoniae.
D000368:Aged; D001428:Bacterial Vaccines / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood / Q000188:drug therapy; D006801:Humans; D007252:Influenza Vaccines / Q000494:pharmacology*; D007251:Influenza, Human / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D011008:Pneumococcal Infections / Q000517:prevention & control; D022242:Pneumococcal Vaccines; D013296:Streptococcus pneumoniae / Q000276:immunology*; D014611:Vaccination; D014859:Warfarin / Q000494:pharmacology*
D001428:Bacterial Vaccines; D007252:Influenza Vaccines; D022242:Pneumococcal Vaccines; D014859:Warfarin