Molecular mechanisms of action of general anesthetics.
While a plethora of information exists describing particular changes caused by anesthetics on the molecular architecture of membranes, it is clear that models for anesthetic action remain unproven by rigid scientific criteria. This article describes historical and contemporary theories of how anesthetics act on a molecular level, and examines the discrepancies between these hypotheses and current data.
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000502:physiology; D006801:Humans; D008051:Lipid Bilayers; D008563:Membrane Lipids / Q000502:physiology*; D008565:Membrane Proteins / Q000502:physiology; D008954:Models, Biological; D012995:Solubility; D013329:Structure-Activity Relationship
D000777:Anesthetics; D008051:Lipid Bilayers; D008563:Membrane Lipids; D008565:Membrane Proteins