The effect of protamine on serum complement activity in aminonucleoside nephropathy.
Combined administration of protamine sulfate (Ps) and aminonucleoside (AN) to rats causes severe nephrotic syndrome and, histologically, focal glomerular sclerosis. These changes are more distinct than those produced by AN alone. While the exact mechanism of Ps acting on AN nephropathy is not known, marked hypocomplementemia was observed regularly after the Ps + AN injection, suggesting that complement is activated and consumed in the kidney. It is suggested that complement may play an important role in AN + Ps nephropathy.
D000818:Animals; D003167:Complement Activation / Q000187:drug effects*; D004347:Drug Interactions; D005923:Glomerulosclerosis, Focal Segmental / Q000139:chemically induced; D009404:Nephrotic Syndrome / Q000139:chemically induced*; D011479:Protamines / Q000008:administration & dosage; D011691:Puromycin / Q000031:analogs & derivatives; D011692:Puromycin Aminonucleoside / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D011479:Protamines; D011691:Puromycin; D011692:Puromycin Aminonucleoside