title: Comparison of three hypotensive anaesthetic methods for middle ear microsurgery.
abstract: Three hypotensive anaesthetic methods were compared in 123 patients undergoing middle ear microsurgery. Hypotension was induced with halothane (1 vol.%), nitroprusside (4.4 micrograms/kg/min) or the combination of halothane (0.5 vol.%) and nitroprusside (1.2 micrograms/kg/min). The compensatory rise in the heart rate was controlled with a beta-adrenergic receptor blocking agent, practolol, the mean need for which was 0.03 mg/kg in the halothane group and 0.1 mg/kg in the other groups. The mean duration of the hypotensive period ranged from 79 to 107 min in the groups. During the hypotension, the average mean arterial pressure ranged from 55 to 60 mmHg (7.33 to 8.00 kPa) and the mean heart rate from 67 to 79 beats/min in the groups. The PaO2 value in the nitroprusside and halothane + nitroprusside groups, but not in the halothane group, decreased statistically and in some cases clinically significantly. The only peroperative side effects were ECG changes (mostly junctional rhythm), the incidence of which ranged from 16 to 24% in the groups. The mean values for the degree of haemostasis rated by the otologist on a visual analogue scale between poor (0 mm) and excellent (100 mm) were 90, 73 and 89 mm in the halothane, nitroprusside and halothane + nitroprusside groups, respectively. Recovery in the halothane group was statistically highly significantly longer than in the other groups. No rebound hypertension occurred in any of the groups after discontinuation of the hypotension. The most common side effect was nausea + vomiting, the incidence of which ranged from 15 to 26% in the groups.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000136:Acid-Base Equilibrium; D000328:Adult; D000768:Anesthesia, General; D001794:Blood Pressure; D004432:Ear, Middle / Q000601:surgery*; D004562:Electrocardiography; D005260:Female; D006221:Halothane; D006487:Hemostasis; D006801:Humans; D007023:Hypotension, Controlled / Q000379:methods*; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D009599:Nitroprusside; D010101:Oxygen Consumption; D010149:Postoperative Pain / Q000517:prevention & control; D011182:Postoperative Care; D011217:Practolol / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D009599:Nitroprusside; D011217:Practolol; D006221:Halothane