Partial hydatidiform mole with diploid karyotype: report of three cases.
Recent studies suggest that a partial mole with a triploid karyotype has little tendency to invade and metastasize and usually requires no therapy other than evacuation. This report describes three patients with a mole of normal diploid karyotype coexisting with a living fetus. Each patient had persistent elevation of human chorionic gonadotropin. Two patients required chemotherapy; one of these had invasive mole. The partial mole with normal diploid karyotype is a distinct clinical entity with the potential for malignant sequelae. The possibility of twin gestation cannot be excluded.
D000328:Adult; D003609:Dactinomycin / Q000627:therapeutic use; D004171:Diploidy; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000235:genetics* / Q000628:therapy; D007621:Karyotyping; D008297:Male; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000235:genetics* / Q000628:therapy; D014619:Vacuum Curettage
D003609:Dactinomycin