title: Interaction of peroxyacetyl nitrate and ozone on pulmonary functions.
abstract: The metabolic and pulmonary function effects were investigated in 10 nonsmoking, young adult men who were exposed for 2 h (20 degrees C (wet-bulb globe temperature) (WBGT] to 4 conditions: (1) filtered air (FA), (2) 0.30 ppm peroxyacetyl nitrate (PAN), (3) 0.45 ppm ozone (O3), and (4) 0.45 ppm O3 + 0.30 ppm PAN (PAN/O3). The subjects alternated 15-min periods of rest and 20-min periods of bicycle ergometer exercise at a work load predetermined to elicit a ventilatory minute volume (VE) of 27 L/min (BTPS). Functional residual capacity (FRC) was determined pre- and postexposure. Forced vital capacity (FVC) was determined before and after exposure, and 5 min after each exercise period. Heart rate was monitored throughout the exposure, and (VE), oxygen uptake (VO2), respiratory rate (fR), and tidal volume (VT) were measured during the last 2 min of each exercise period. There were no changes in any variable consequent to FA or PAN exposure. The only metabolic changes to occur because of O3 and PAN/O3 exposure were a decrease in VT, a concomitant increase in fR, and consequently no change in VE. Both O3 and PAN/O3 induced significant (p less than 0.05) decrements in FVC, FEV1.0, FEV2.0, FEV3.0, FEF25-75%, IC, ERV, and TLC. The decrements after PAN/O3 exposure averaged 10% greater than the decrements after O3 exposure. The results suggest an interactive effect between PAN and O3, possibly explained by total oxidant load.
mesh_terms: D000085:Acetates / Q000494:pharmacology*; D000293:Adolescent; D000328:Adult; D004347:Drug Interactions; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000187:drug effects*; D008297:Male; D008450:Maximal Midexpiratory Flow Rate; D010101:Oxygen Consumption; D010126:Ozone / Q000494:pharmacology*; D010463:Peracetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology*; D005082:Physical Exertion; D012129:Respiratory Function Tests; D013990:Tidal Volume; D013997:Time Factors; D014109:Total Lung Capacity; D014797:Vital Capacity
chemical_list: D000085:Acetates; D010126:Ozone; D010463:Peracetic Acid; C004185:peroxyacetyl nitrate