title: Stereoselective binding of disopyramide to human plasma protein.
abstract: The binding of racemic disopyramide and its two enantiomers to protein were compared in two samples of human plasma, two samples of freshly drawn serum and in a solution of alpha 1-acid glycoprotein. The binding of S(+)-disopyramide was higher at all concentrations as compared to to R(-)-disopyramide, and the binding of the racemate was intermediate. Differences in binding were due to differences in the association constant.
mesh_terms: D001665:Binding Sites; D001798:Blood Proteins / Q000378:metabolism*; D004206:Disopyramide / Q000097:blood*; D006801:Humans; D013237:Stereoisomerism
chemical_list: D001798:Blood Proteins; D004206:Disopyramide