The blood pressure and metabolic effects of 19-nor-deoxycorticosterone and 19-nor-progesterone in sheep.
The present study examines the blood pressure and metabolic effects of 5 day infusions of 19-nor-deoxycorticosterone (19-nor-DOC) and 19- nor-progesterone (19-nor-PROG) in the intact conscious sheep. Both these steroids raise blood pressure in the rat. 19-nor-DOC (5 mg/d) produced a significant increase in mean arterial pressure (MAP) of 17 mmHg on day 5 (p less than 0.001), associated with 'mineralocorticoid' effects hypokalaemia, hypernatraemia and an initial urinary sodium retention. In contrast 19-nor-PROG (5 mg/d and 50 mg/d) had no effect on MAP and displayed no 'mineralocorticoid' activity.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003900:Desoxycorticosterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D009652:Norpregnenes / Q000494:pharmacology*; D009653:Norprogesterones / Q000494:pharmacology*; D011188:Potassium / Q000097:blood; D012756:Sheep; D012964:Sodium / Q000097:blood; D014882:Water-Electrolyte Balance / Q000187:drug effects
D009652:Norpregnenes; D009653:Norprogesterones; C030703:19-norprogesterone; D003900:Desoxycorticosterone; C019026:19-nordeoxycorticosterone; D012964:Sodium; D011188:Potassium