title: Bispyridinamines: a new class of topical antimicrobial agents as inhibitors of dental plaque.
abstract: A series of N,N'-polyalkylenebis[4-(substituted-amino)pyridines] has been prepared, and members have been evaluated as potential anti-dental plaque agents. From among the most active members of the series, one compound, N,N'-[1,10-decanediyldi-1(4H)-pyridinyl-4-ylidene]bis(1-octanam ine) dihydrochloride, octenidine, was selected as a candidate for clinical study.
mesh_terms: D000631:Aminopyridines / Q000627:therapeutic use*; D003773:Dental Plaque / Q000188:drug therapy*; D006801:Humans; D013329:Structure-Activity Relationship
chemical_list: D000631:Aminopyridines