[Changes in the cholinesterase activity and glucose concentration in the blood induced by paraoxon in rabbits immunized against paraoxon].
The immunization of rabbits with a paraoxon-HSA-conjugate resulted in an antibody response with titres of 1:25000 to 1:100000 of antisera dilution and average affinity constants K0 of 10(6) M-1 and heterogeneity indices of 0.8 to 0.9 calculated by means of the Sips equation. The serum cholinesterases and the erythrocyte acetylcholinesterase in immunized rabbits were protected against a stronger inhibition by parenteral application of paraoxon. An increase of blood glucose after paraoxon application to immunized rabbits could not be observed but was detectable in unimmunized animals.
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002802:Cholinesterases / Q000097:blood*; D005949:Glucose Oxidase / Q000378:metabolism; D007114:Immunization; D010261:Paraoxon / Q000276:immunology / Q000633:toxicity*; D011817:Rabbits
D001786:Blood Glucose; D005949:Glucose Oxidase; D000110:Acetylcholinesterase; D002802:Cholinesterases; D010261:Paraoxon
Veränderungen der Cholinesteraseaktivitäten und der Glukosekonzentration im Blut durch Paraoxon bei gegen Paraoxon immunisierten Kaninchen.