[D-Arg]Kyotorphin-induced ipsilateral rotation: evidence for in vivo effects independent of Met-enkephalin release.
Kyotorphin (Tyr-Arg) and its stable analogue [D-Arg]kyotorphin were injected into the substantia nigra of rats. Intranigral [D-Arg]-kyotorphin resulted in consistent ipsilateral rotational behavior which was naloxone-reversible. In comparison, intranigral Met-enkephalin induces naloxone-sensitive contralateral rotation. These results indicate a pharmacological effect of [D-Arg]kyotorphin in the substantia nigra that would appear to be independent of Met-enkephalin release.
D000818:Animals; D004723:Endorphins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D004744:Enkephalin, Methionine / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012399:Rotation; D013378:Substantia Nigra / Q000187:drug effects*
D004723:Endorphins; C019448:kyotorphin; D009270:Naloxone; D004744:Enkephalin, Methionine