Selective IgA deficiency associated with recurrent sinopulmonary infections in sarcoidosis.
We present a case of pulmonary sarcoidosis associated with serum and secretory IgA deficiency. This association has only previously been reported in 6 patients and may be coincidental. However, in light of current knowledge of the immunoregulatory defects postulated for sarcoidosis and for patients with selective IgA deficiency, 2 other possible explanations for the association of sarcoidosis and selective IgA deficiency are presented.
D000328:Adult; D004406:Dysgammaglobulinemia / Q000276:immunology*; D006801:Humans; D017098:IgA Deficiency; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D008171:Lung Diseases / Q000276:immunology*; D008297:Male; D010254:Paranasal Sinus Diseases / Q000276:immunology; D012008:Recurrence; D012141:Respiratory Tract Infections / Q000276:immunology*; D012507:Sarcoidosis / Q000276:immunology*
D007071:Immunoglobulin A, Secretory