[Synthesis and analgesic activity of 4-(3-oxo-1,2-benzoisothiazoline-2-yl)phenylalkanoic derivatives].
The synthesis of a new series of 4-(3-oxo-1,2-benzisothiazolin-2-yl)phenylalkanoic compounds and some of their functional derivatives is described. The compounds, on the basis of data obtained from 1,2-benzisothiazolin-3-one derivatives, were biologically examined mainly for their antiphlogistic and analgesic actions. Results obtained, in analyzing the relationship between structure and pharmacological actions, suggest that both 4-(3-oxo-1,2-benzisothiazolin-2-yl)-phenyalkanoic acids and o-sulphobenzimido alkanoic esters are endowed with pain-killing effects comparable in potency and efficacy with phenylbutazone.
D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D051381:Rats; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013997:Time Factors
D000700:Analgesics; D013844:Thiazoles
Sintesi ed attività antalgiche di derivati 4-(3-oxo-1,2-benzisotiazolin-2-il)fenilalcanoici.