title: Conversion of longstanding atrial flutter to sinus rhythm and transient complete A-V block following oral administration of verapamil. Report of a case.
abstract: In a patient with ischaemic heart disease chronic atrial flutter reverted to sinus rhythm during treatment with oral Verapamil, given at dosage of 240 mg once a day in order to prevent spontaneous angina. Such an unexpected event was accompanied by a remarkable sinus node depression and by a transient complete a-v block, that gradually subsides leaving a slight permanent a-v conduction delay. Either a higher bioavailability of the drug or an extremely increased sensitivity of the receptors can explain such a marked electrophysiological effect at a moderate drug dosage.
mesh_terms: D000368:Aged; D001282:Atrial Flutter / Q000188:drug therapy* / Q000503:physiopathology; D004562:Electrocardiography; D006327:Heart Block / Q000139:chemically induced*; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000150:complications; D014700:Verapamil / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D014700:Verapamil