Antagonism of 5-hydroxytryptamine-evoked excitation in the superficial dorsal horn of the cat spinal cord by methysergide.
Ionophoretically applied methysergide was tested on 9 units excited by 5-hydroxytryptamine (5-HT) recorded in the superficial dorsal horn of cat spinal cord. In all cases, methysergide produced a prolonged and repeatable antagonism of the excitatory action of 5-HT, but it had no effect on glutamate-evoked activity or on that caused by adequate stimulation of the receptive field. This result supports the proposal that excitation by 5-HT is a direct synaptic effect, and not a 'non-specific' action.
D000818:Animals; D002415:Cats; D005071:Evoked Potentials / Q000187:drug effects; D008784:Methysergide / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology*; D013116:Spinal Cord / Q000187:drug effects*; D013569:Synapses / Q000187:drug effects
D012701:Serotonin; D008784:Methysergide