[Radioimmunoassay in the testing of new pharmacological agents].
The activity of Parathorm, a pharmaceutical obtained from parathyroid hormone (PTH), was studied. Human blood plasma proteins as well as bivalent anions have been shown to produce a negative effect on the antigen-antibody interaction. The proportion of the PTH-protein complexes with the elevation of the pharmaceutical dose is constant in many concentrations whereas with the elevation of the PTH dose the PTH-low molecular complexes account for ever increasing proportion of the radioactive complexes.
D001798:Blood Proteins / Q000378:metabolism; D002021:Buffers; D006801:Humans; D066298:In Vitro Techniques; D007700:Kinetics; D010281:Parathyroid Hormone / Q000097:blood* / Q000627:therapeutic use; D011485:Protein Binding; D011863:Radioimmunoassay
D001798:Blood Proteins; D002021:Buffers; D010281:Parathyroid Hormone
Radioimmunologicheskiĭ metod pri ispytanii novykh farmakologicheskikhsredstv.