Hormonal monitoring of early pregnancy by a direct radioimmunoassay of steroid glucuronides in first morning urine.
The usefulness of the direct 4-hour radioimmunoassay of estriol-16-glucuronide (E3G) and pregnanediol-3-glucuronide (P2G) in first morning urine (FMU) for establishing a prognosis of the early pregnancy outcome was evaluated in 106 patients that became pregnant. Microaliquots of FMU were serially assayed from day 3 of the conception cycle until day 80 of pregnancy. The E3G and P2G profiles of 19 pregnancies which terminated in spontaneous abortion with either a diagnosis of the blighted ovum syndrome (n = 11) or presumption of a corpus luteum/trophoblast failure (n = 8) have been compared with those of clinically normal pregnancies (n = 87). Normal pregnancies displayed typical patterns of E3G and P2G development, while variations were observed in abortive events that reflected changes of the fetoplacental unit.
D000022:Abortion, Spontaneous / Q000175:diagnosis; D004964:Estriol / Q000031:analogs & derivatives* / Q000652:urine; D005260:Female; D006801:Humans; D011247:Pregnancy; D011276:Pregnanediol / Q000031:analogs & derivatives* / Q000652:urine; D011379:Prognosis; D011863:Radioimmunoassay
C022270:pregnanediol-3 alpha-glucuronide; C032095:estriol glucuronide; D004964:Estriol; D011276:Pregnanediol