title: Primary gastrin cell hyperplasia. Report of five cases and a review of the literature.
abstract: Primary gastrin cell hyperfunction of the gastric antrum as a clinical syndrome consists of basal hypergastrinemia, an exaggerated gastrin response to feeding, the absence of any ectopic source of gastrin secretion, and peptic ulcer disease. The number of G-cells were quantitated in the gastric antrum of five patients with clinically diagnosed primary G-cell hyperfunction, and the results were compared to controls with a variety of gastric diseases. Patients with the clinical diagnosis of primary G-cell hyperfunction had a significantly increased number of antral G-cells (p less than 0.05). The clinical syndrome of primary G-cell hyperplasia appears to be associated with hyperplasia of G-cells rather than with the hypersecretion of gastrin by a normal number of G-cells.
mesh_terms: D000328:Adult; D002838:Chromaffin System / Q000473:pathology*; D003937:Diagnosis, Differential; D004759:Enterochromaffin Cells / Q000473:pathology*; D005744:Gastric Acid / Q000378:metabolism; D005753:Gastric Mucosa / Q000473:pathology; D005755:Gastrins / Q000097:blood* / Q000378:metabolism; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000150:complications; D011706:Pyloric Antrum / Q000473:pathology*; D013272:Stomach Diseases / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D013577:Syndrome; D015043:Zollinger-Ellison Syndrome / Q000175:diagnosis
chemical_list: D005755:Gastrins