Cortisol suppression index: a further evaluation.
The cortisol suppression index (CSI) is the ratio of pre- to postdexamethasone plasma cortisol concentrations. The 8 a.m. CSI was previously found to identify 66% of a sample of psychiatric inpatients with major depression. In the present study, a 4 p.m. CSI identified 71% of psychiatric inpatients with major depression, in contrast to 53% when using DST criteria alone. This finding adds further validation to the CSI. Further studies of the utility of the CSI are suggested to help improve the detection of major depression.
D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis*; D003907:Dexamethasone; D005069:Evaluation Studies as Topic; D006760:Hospitalization; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*
D003907:Dexamethasone; D006854:Hydrocortisone