[The use of short-term tests for oxidation studies of drugs. 2. Kinetics of 2-mercaptobenzthiazole oxidation].
By the example of 2-mercapto-benzthiazole it has been ascertained how far the k25 value obtained by extrapolation from the Arrhenius equation corresponds with the k25 value of the long-term test. To record besides oxidation products the 2-mercapto-benzthiazole, a UV-spectrophotometric method has been produced. The isothermal short-term test has been performed at 50, 60, 70, 80 and 90 degrees C after identification of the temperature independence of the reaction mechanism and of the reaction rate pH dependence.
D052160:Benzothiazoles; D002626:Chemistry, Pharmaceutical; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D010084:Oxidation-Reduction; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature; D013844:Thiazoles / Q000032:analysis*
D052160:Benzothiazoles; D013844:Thiazoles; C005563:captax
Untersuchungen zur Anwendbarkeit des Kurzzeittestes für oxidationsempfindliche Pharmaka. 2. Mitteilung: Kinetik der 2-Mercapto-benzthiazoloxidation.