Pharmacokinetics of GdDTPA/dimeglumine after intravenous injection into healthy volunteers.
Pharmacokinetic studies of GdDTPA/dimeglumine in man show a rapid renal clearance and no evidence for dissociation or retention of the complex in the body. These features, in conjunction with its strong proton relaxation enhancement and its low toxicity suggest that this complex may be an excellent contrast medium for magnetic resonance imaging.
D003287:Contrast Media; D004341:Drug Evaluation; D005682:Gadolinium; D006801:Humans; D007275:Injections, Intravenous; D007668:Kidney / Q000502:physiology; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008536:Meglumine / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D008657:Metabolic Clearance Rate; D004369:Pentetic Acid / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D013012:Sorbitol / Q000031:analogs & derivatives*
D003287:Contrast Media; D013012:Sorbitol; D008536:Meglumine; D004369:Pentetic Acid; D005682:Gadolinium