title: Neutrophil migration in vitro and in vivo during hypothermia.
abstract: The effect of hypothermia on pig leukocyte migration in vitro and in vivo was studied. Neutrophil chemotaxis in vitro under agarose was significantly impaired at 29 degrees C (2.7 +/- 0.6 [mean +/- standard error]; 37 degrees C, 7.1 +/- 1.1). Leukocytes isolated from hypothermic pigs and tested at 37 degrees C migrated normally (7.8 +/- 0.6). Neutrophil and monocyte migration in vivo was markedly reduced at 29 degrees C. Reduced inflammatory responses may contribute to increased infections during hypothermia.
mesh_terms: D000818:Animals; D002634:Chemotaxis, Leukocyte; D003080:Cold Temperature; D007035:Hypothermia / Q000276:immunology / Q000503:physiopathology*; D007111:Immunity, Cellular; D009504:Neutrophils / Q000502:physiology*; D013552:Swine