title: Assessment of immunological mechanism in infertility of the rat after experimental testicular torsion.
abstract: A necrotic torted testis left in the scrotum affects the contralateral testis, resulting in depressed fertility. It was suggested that testicular torsion provoked a systemic response of an immunologic nature. In order to prove this theory, 56 rats were operated. Ten had a sham operation, in 17 a testis was torted and excised after 24 h, and in 29 a testis was torted and excised after 24 h, and in 29 a testis was torted but left in situ till the sacrifice. Antisperm-antibodies were not found in any phase of the experiment in the sham group. Using indirect immunofluorescence, antisperm-antibodies were found in the sera of 8/17 rats of the orchiectomy group and in 24/29 of the detorted group. In the direct immunofluorescence study, all the antibodies were localized in the tail of the spermatozoid. The antisperm-antibodies disappeared after 3 to 6 months.
mesh_terms: D000818:Animals; D001323:Autoantibodies / Q000276:immunology; D007248:Infertility, Male / Q000209:etiology / Q000276:immunology*; D008297:Male; D051381:Rats; D013086:Spermatic Cord Torsion / Q000150:complications / Q000276:immunology*; D013091:Spermatogenesis; D013094:Spermatozoa / Q000276:immunology
chemical_list: D001323:Autoantibodies