title: [Cytogenetic effects of 1,4-dihydropyridine in various test systems].
abstract: Cytogenetic effect of 1,4-dihydropyridine was studied in different test-systems. The preparation is shown to decrease the level of complete sex-chromosome losses in Drosophila and chromosome aberration frequency in Allium fistulosum seedlings. The preparation does not affect spontaneous mutability of bone marrow cells in mice, high doses of the preparation have no mutagenic potential. Thus, 1,4-dihydropyridine shows antimutagenic activity reducing the chromosome mutation level in sex and somatic cells of eucaryotic organisms. Absence of the effect on mice chromosomes may testify to the specificity of 1,4-dihydropyridine action.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D004095:Dihydropyridines; D004305:Dose-Response Relationship, Drug; D004330:Drosophila; D005260:Female; D005720:Gamma Rays; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009154:Mutation; D011725:Pyridines / Q000494:pharmacology*; D012639:Seeds / Q000187:drug effects; D012730:Sex Chromosomes / Q000187:drug effects / Q000528:radiation effects
chemical_list: D004095:Dihydropyridines; D011725:Pyridines; C038806:1,4-dihydropyridine
vernacular_title: Tsitogeneticheskiĭ éffekt 1,4-digidropiridina v razlichnykh test-sistemakh.