Transfer of ferritin-bound iron to adriamycin.
Interactions of adriamycin with ferritin-bound iron have been investigated. It is demonstrated (i) that adriamycin stimulates an iron-dependent lipid peroxidation in submitochondrial particles in the presence of ferritin, and (ii) that incubation of adriamycin with ferritin results in a slow transfer of iron to adriamycin with formation of an adriamycin-iron complex. The results are discussed in relation to the possible role for intracellular iron in adriamycin toxicity.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D004317:Doxorubicin / Q000378:metabolism* / Q000494:pharmacology; D004347:Drug Interactions; D005293:Ferritins / Q000378:metabolism* / Q000494:pharmacology; D007501:Iron / Q000378:metabolism* / Q000494:pharmacology; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors; D009247:NADH, NADPH Oxidoreductases / Q000037:antagonists & inhibitors; D013053:Spectrophotometry; D013367:Submitochondrial Particles / Q000201:enzymology; D013552:Swine
D009097:Multienzyme Complexes; D000244:Adenosine Diphosphate; D004317:Doxorubicin; D005293:Ferritins; D007501:Iron; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases