[Effect of levorin on the intracellular pool of free amino acids in Ehrlich ascites carcinoma cells].
Levorene, a polyenic antibiotic, lowered the concentration of amino acids in the cells of Ehrlich carcinoma. The decrease in the intracellular level of the amino acids was due not only to inhibition of their entrance to the cells but also to their increased leaching from the cells. The effect of levorene on the intracellular level of the neutral amino acids was higher than that on the main amino acids which was associated with different sensitivity of the amino acid transport systems to the antibiotic.
D000596:Amino Acids / Q000032:analysis / Q000378:metabolism*; D000818:Animals; D000935:Antifungal Agents / Q000627:therapeutic use*; D001692:Biological Transport / Q000187:drug effects; D002174:Candicidin / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000032:analysis / Q000188:drug therapy* / Q000378:metabolism; D002478:Cells, Cultured; D013997:Time Factors
D000596:Amino Acids; D000935:Antifungal Agents; D002174:Candicidin
Vliianie levorina na vnutrikletochnyĭ fond svobodnykh aminokislot v kletkakh astsitnoĭ kartsinomy Erlikha.