The actions of the hydroxamic acid of gamma amino butyric acid on the isolated rabbit atria and jejunum.
The hydroxamic acid of gamma amino butyric acid (HAGABA) has been prepared and was studied in the isolated rabbit atria and jejunum. HAGABA did not interfere with the spontaneous contractile rhythm and frequency of the isolated atria except in large mM concentrations in the bath. HAGABA displayed a biphasic effect in the isolated jejunum, which manifested itself first as stimulation followed by inhibition with an increasing concentration in the bath. Bicuculline and HAGABA did not antagonize each other in the enteric nervous system, but rather an augmentation was observed.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D005260:Female; D006321:Heart / Q000187:drug effects*; D006325:Heart Atria / Q000187:drug effects; D066298:In Vitro Techniques; D007583:Jejunum / Q000187:drug effects*; D008297:Male; D011817:Rabbits; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D005680:gamma-Aminobutyric Acid; C034160:gamma-aminobutyric acid hydroxamate; D000109:Acetylcholine; D001640:Bicuculline