title: Multiple primary malignant tumors involving the large bowel.
abstract: We reviewed 5680 autopsy protocols in order to determine the frequency of Multiple Primary Malignant Tumors (MPMT) in different organs. The large bowel was the organ most frequently involved, making up to 32 per cent of all MPMT cases. Of 26 patients with colorectal MPMT, six were multicentric in the large bowel, and 20 were associated with extracolonic malignancies. The tissues harboring primary malignancies were, in order of decreasing frequency, liver, lung, and female and male reproductive organs. We compared the exact location of large bowel cancers in patients with and without a prior cholecystectomy; there was no statistically significant difference between the two groups, especially for right-sided colonic carcinoma in women.
mesh_terms: D000368:Aged; D002430:Cecal Neoplasms / Q000473:pathology; D003110:Colonic Neoplasms / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009378:Neoplasms, Multiple Primary / Q000473:pathology* / Q000503:physiopathology; D012004:Rectal Neoplasms / Q000473:pathology* / Q000503:physiopathology; D012737:Sex Factors; D012811:Sigmoid Neoplasms / Q000473:pathology