Changes in distribution of the phases of mitosis in human tumor xenografts following drug treatment.
Distribution of individual mitotic phases in different human xenografts on nude mice showed significant changes after treatment with a range of drugs when compared with untreated controls. The total amount of mitoses in prophase significantly decreased in all responsive tumors while those in all other phases increased but in a very variable degree. There was some correlation in between the range of the mitotic phase distribution changes and the degree of tumor response to treatment.
D000818:Animals; D006801:Humans; D051379:Mice; D008808:Mice, Inbred CBA; D008819:Mice, Nude; D008938:Mitosis / Q000187:drug effects*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology*; D014183:Transplantation, Heterologous