title: [A new technic for the sealing of a frontobasal cerebrospinal fluid fistula. Experiences with a hardening alcoholic protamine solution].
abstract: Fractures of the frontal base of the skull are often accompanied by rhinoliquorrhea. To prevent infections of the brain they must always be closed surgically. We report on a new method of closing the dura mater defect using an alcoholic prolamine solution, which hardens within a few minutes. After 40 to 90 days the mass has been replaced by connective tissue. We describe our experience with 24 patients who were successfully operated on using this method and followed up for two years.
mesh_terms: D000818:Animals; D002559:Cerebrospinal Fluid Rhinorrhea / Q000601:surgery*; D003973:Diatrizoate; D004338:Drug Combinations; D004388:Dura Mater / Q000293:injuries; D005004:Ethmoid Bone / Q000293:injuries; D005227:Fatty Acids; D005500:Follow-Up Studies; D005624:Frontal Bone / Q000293:injuries*; D006801:Humans; D010256:Paranasal Sinuses / Q000293:injuries; D011409:Propylene Glycols; D011506:Proteins / Q000627:therapeutic use*; D011817:Rabbits; D051381:Rats; D012887:Skull Fractures / Q000601:surgery*; D014945:Wound Healing / Q000187:drug effects; D015028:Zein
chemical_list: D004338:Drug Combinations; D005227:Fatty Acids; D011409:Propylene Glycols; D011506:Proteins; D003973:Diatrizoate; D015028:Zein; C020481:alcoholic prolamine solution
vernacular_title: Eine neue Technik zum Verschluss der frontobasalen Liquorfistel. Erfahrungen mit einer aushärtenden alkoholischen Prolaminlösung.