[Effect of bone marrow mediator myelopeptides on the summation-threshold index and behavioral reactions of rats].
Transmitter peptides having immunostimulant and endorphine-like properties were isolated from supernatant of medullary cell culture. Bioregulatory peptides were called myelopeptides. Myelopeptides provoked changes of the summation-threshold index in rats, which augmented in time. These changes pointed to the realization of the analgetic effect of myelopeptides via the spinal-stem structures of the central nervous system. Having a remarkable analgesic effect myelopeptides administered in the doses tested did not produce any action on the behavioral responses. The latter circumstance makes them differ from narcotic analgesics and known endorphines.
D000276:Adjuvants, Immunologic / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001853:Bone Marrow / Q000276:immunology*; D005260:Female; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D010146:Pain / Q000503:physiopathology; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology*; D051381:Rats; D012684:Sensory Thresholds / Q000187:drug effects; D013552:Swine; D013997:Time Factors
D000276:Adjuvants, Immunologic; D010455:Peptides; D009270:Naloxone
Vliianie kostnomogovykh mediatorov-mielopeptidov na summatsionno-porogovyĭ pokazatel'i povedencheskie reaktsii u krys.