A rapid method for repeated collection of blood from the tail vein of rats.
A method was developed for obtaining serial blood samples from the tail vein of rats. Seventy microliters of blood were collected at the rate of approximately one sample per minute for the quantitative determination of whole blood clearance of radiolabeled compounds. The technique was rapid, reproducible, and kept stress to the test animals at a minimum.
D000818:Animals; D001800:Blood Specimen Collection / Q000379:methods / Q000662:veterinary*; D005260:Female; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344 / Q000097:blood*; D011919:Rats, Inbred Strains / Q000097:blood*; D013623:Tail / Q000098:blood supply; D014680:Veins