Plasma lipid peroxides and alpha-tocopherol in critically ill patients.
Plasma lipid peroxide measured as thiobarbituric acid reactive substances (TBARS) and alpha-tocopherol levels in 24 critically ill patients were compared with those of control subjects. The mean plasma alpha-tocopherol level was significantly lower and the mean TBARS level was significantly higher in critically ill patients. Eight ICU patients developed disseminated intravascular coagulation (DIC); the mean TBARS level during DIC was significantly above the mean pre-DIC level. These results indicate that lipid peroxidation may contribute to the development of DIC in critically ill patients.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D002675:Child, Preschool; D003422:Critical Care; D004211:Disseminated Intravascular Coagulation / Q000378:metabolism; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013858:Thiobarbiturates / Q000378:metabolism; D014810:Vitamin E / Q000097:blood* / Q000378:metabolism
D008054:Lipid Peroxides; D013858:Thiobarbiturates; D014810:Vitamin E; C029684:thiobarbituric acid