Effects of beta-neo-endorphin on behaviors in mice using multi-dimensional behavioral analyses.
The effect of beta-neo-endorphin on mouse behaviors were examined using multi-dimensional behavioral analyser. The intracerebral injection of beta-neo-endorphin (30 micrograms) decreased the ambulation. However, the decrease in the ambulation was not antagonized by pretreatment with 2 and 4 mg/kg doses of naloxone. These results suggest that the decrease in the ambulation induced by beta-neo-endorphin is not mediated by opioid receptors in the brain.
D000818:Animals; D001921:Brain / Q000187:drug effects; D004723:Endorphins / Q000494:pharmacology*; D007276:Injections, Intraventricular; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology; D013997:Time Factors; D001615:beta-Endorphin / Q000031:analogs & derivatives*
D004723:Endorphins; D009270:Naloxone; D001615:beta-Endorphin; C030719:beta-neo-endorphin