The proliferative state of early erythropoietic progenitor cells (BFU-E) in human umbilical cord blood: low probability of finding BFU-E in DNA synthesis.
We have investigated the proliferative behavior of early erythropoietic progenitor cells (BFU-E) in human umbilical cord blood with hydroxyurea and tritiated-thymidine suicide experiments. Our results indicate that the great majority of these progenitors are normally either in a quiescent state with respect to DNA synthesis or in a prolonged cell cycle experimentally indistinguishable from this state. In this regard, neonatal BFU-E resemble adult circulating BFU-E.
D002455:Cell Division; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004261:DNA Replication; D004920:Erythropoiesis; D005260:Female; D005312:Fetal Blood / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000502:physiology*; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology; D011247:Pregnancy; D014470:Umbilical Cord
D006918:Hydroxyurea