[Effects of clindamycin and josamycin in experimental Toxoplasma gondii infections].
The effects of clindamycin and josamycin on experimental toxoplasmosis of mice (RH strain) are studied. Oral administration of clindamycin 800 mg/kg daily for 14 days cured 80% of Toxoplasma-infected mice at 60 days after infection. Josamycin, administered subcutaneously at 100, 200, 500, 1000 mg/kg daily for 14 days did not prevent death due to acute infection, and no difference was demonstrated with untreated infected mice.
D000284:Administration, Oral; D000818:Animals; D002981:Clindamycin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D007279:Injections, Subcutaneous; D007933:Leucomycins / Q000008:administration & dosage / Q000627:therapeutic use*; D051379:Mice; D014124:Toxoplasmosis, Animal / Q000188:drug therapy*
D007933:Leucomycins; D002981:Clindamycin
Attività della clindamicina e della josamicina nell'infezione sperimentale da Toxoplasma gondii.