[Glucocorticoid hormones and the immune response of CBA and C57BL strains of mice of different ages].
Experiments on CBA and C57BL mice were made to study the relationship between the function of the hypothalamus-pituitary-adrenocortical system (HPACS) and the intensity of immune response to sheep red blood cells. The immune response evaluated from the number of rosette-forming cells appeared to be lowered in low-respondent C57BL mice, depending on the age, whereas in CBA mice, the lowering of the immune response was not age-dependent. The intensity of the HPACS response measured according to the level of 11-OHCS two hours after immunization was not found to be dependent on the genetic differences. However, the level of 11-OHCS significantly dropped with age only in C57BL mice with a low response to sheep red blood cells. Thus, a correlation was discovered between the intensity of immune response to T-dependent antigen and the function of the HPACS, which was particularly noticeable during aging of mice belonging to a definite genotype.
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000375:Aging; D000818:Animals; D000937:Antigen-Antibody Reactions; D005938:Glucocorticoids / Q000502:physiology*; D007114:Immunization; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology*; D008808:Mice, Inbred CBA / Q000276:immunology*; D012397:Rosette Formation
D015062:11-Hydroxycorticosteroids; D005938:Glucocorticoids
Gliukokortikoidnye gormony i immunnyĭ otvet u mysheĭ linii CBA i C57BL raznogo vozrasta.