Effects of extracellular calcium and magnesium on junctional intercellular communication in human fibroblasts.
The role of extracellular calcium and magnesium in intercellular communication via permeable junctions was studied by measuring metabolic co-operation between ASS- and ASL- human fibroblasts. Communication through pre-existing junctions was not affected by the removal of extracellular calcium and magnesium from the medium. On the other hand, the establishment of communication through new permeable junctions, when ASS- and ASL- cells were mixed, was dependent on the presence of extracellular calcium and magnesium.
D002118:Calcium / Q000494:pharmacology*; D002450:Cell Communication / Q000187:drug effects*; D002460:Cell Line; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D007365:Intercellular Junctions / Q000187:drug effects / Q000502:physiology* / Q000648:ultrastructure; D007700:Kinetics; D008274:Magnesium / Q000494:pharmacology*; D012867:Skin / Q000166:cytology
D008274:Magnesium; D002118:Calcium