Effects of acebutolol combined with mefruside on total-body and serum potassium in essential hypertensive patients.
Fifteen essentially hypertensive patients were treated with a fixed combination of the beta-adrenoceptor antagonist acebutolol and the diuretic substance mefruside for 6 weeks. The systolic and diastolic blood pressure as well as the heart rate were significantly reduced. Before and after the treatment period, total-body and serum potassium were examined. Both parameters were not significantly changed. Diuretic therapy causes hypokalemia by increased potassium excretion in the distal tubulus, whereas beta-adrenoceptor antagonists could compensate this effect by a mechanism which is not yet clarified.
D000070:Acebutolol / Q000009:adverse effects* / Q000627:therapeutic use; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004232:Diuretics / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008529:Mefruside / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D011188:Potassium / Q000097:blood / Q000378:metabolism*
D004232:Diuretics; D000070:Acebutolol; D011188:Potassium; D008529:Mefruside