Neonatal pancreatic function in infants born to mothers with gestational and overt diabetes.
Neonatal pancreatic function was assessed in infants born to non-diabetic mothers and to mothers with well-controlled gestational diabetes (GD) and overt diabetes (OD) using cord blood C-peptide estimations and the calculation of cord C-peptide/glucose ratios. Exaggerated pancreatic function was present in infants born to mothers with GD. In these infants the increased cord C-peptide values and cord C-peptide/glucose ratios correlated with their increased birth weight ratios. These results could not be explained on the basis of maternal hyperglycaemia and a possible intrinsic difference in pancreatic response between infants born to mothers with GD and those born to mothers with OD is suggested.
D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000032:analysis; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D010179:Pancreas / Q000502:physiology*; D010186:Pancreatic Function Tests; D011247:Pregnancy; D011254:Pregnancy in Diabetics; D011446:Prospective Studies
D001786:Blood Glucose; D002096:C-Peptide