Cerebral antioedematous effect of Teproside and of some vincamine derivatives.
Alkyltin compounds are known to produce in the rat a selective oedema of the CNS, especially of the white matter. Vincamine and vincamine derivatives, among which Teproside is the most potent, are able to prevent the occurrence of such an oedematous reaction whereas xanthine derivatives and papaverine fail to prevent this oedema. It is suggested that there may be a potentiation of the effect of vincamine by the xanthine part of the Teproside chemical structure.
D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced / Q000188:drug therapy*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013806:Theophylline / Q000494:pharmacology; D014220:Trialkyltin Compounds / Q000633:toxicity*; D014267:Triethyltin Compounds / Q000633:toxicity*; D014748:Vinca Alkaloids / Q000494:pharmacology* / Q000627:therapeutic use*; D014749:Vincamine / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000627:therapeutic use*
D014220:Trialkyltin Compounds; D014267:Triethyltin Compounds; D014748:Vinca Alkaloids; C038060:vincamine teproside; D014749:Vincamine; D013806:Theophylline