title: Systematic error associated with apparatus 2 of the USP dissolution test V: Interaction of two tableted prednisone formulations with glass and plastic vessels.
abstract: Recently marketed glass vessels that are uniform and pass USP specifications were compared with uniform plastic vessels that also pass USP specifications. Two lots of prednisone tablets, Tablet 1 and Tablet 2, were tested in both types of vessels. Tablet 1 gave higher results (+12.7% of label claim) in glass vessels at 50 rpm but gave equivalent results in either vessel at 75 rpm. Tablet 2 gave equivalent results in either vessel at 50 rpm but gave higher results (+22% of label claim) in glass vessels at 75 rpm. The type of vessel used to obtain dissolution results for tablets should be specified.
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000295:instrumentation*; D005898:Glass; D010969:Plastics; D011241:Prednisone / Q000032:analysis*; D012016:Reference Values; D012995:Solubility; D013607:Tablets
chemical_list: D010969:Plastics; D013607:Tablets; D011241:Prednisone