Acute behavioral toxicity of the organophosphate sarin in rats.
Three experiments were performed to determine the behavioral effects of acutely administered isopropyl methylphosphonofluoridate, sarin (61-115 micrograms/kg, SC) to male rats. Dosages of 71 micrograms/kg or greater produced conditioned flavor aversions while spontaneous locomotor activity was increased at 61 micrograms/kg and significantly decreased at dosages of 84 to 115 micrograms/kg, when compared to vehicle control levels. Significant decrements in rotorod performance were observed at 98 and 115 micrograms/kg sarin. The LD50 of sarin was determined to be 165 micrograms/kg. Behavioral alterations were thus obtained at dosages that were between 37 and 59 percent of the LD50.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D007928:Lethal Dose 50; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009943:Organophosphorus Compounds / Q000633:toxicity*; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012524:Sarin / Q000633:toxicity*; D013649:Taste / Q000187:drug effects
D009943:Organophosphorus Compounds; D012524:Sarin