title: Changes in distribution of the phases of mitosis in human tumor xenografts following drug treatment.
abstract: Distribution of individual mitotic phases in different human xenografts on nude mice showed significant changes after treatment with a range of drugs when compared with untreated controls. The total amount of mitoses in prophase significantly decreased in all responsive tumors while those in all other phases increased but in a very variable degree. There was some correlation in between the range of the mitotic phase distribution changes and the degree of tumor response to treatment.
mesh_terms: D000818:Animals; D006801:Humans; D051379:Mice; D008808:Mice, Inbred CBA; D008819:Mice, Nude; D008938:Mitosis / Q000187:drug effects*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology*; D014183:Transplantation, Heterologous