Leg muscle circulation by 133Xenon clearance as a predictor of cardiovascular disease in an aged population.
In a 10-year cardiovascular survey of an unselected population aged 70 at entry. 133Xenon clearance was carried out in the anterior tibial muscle in both legs after maximal exercise during ischaemia in 211 men and 166 women. The maximal blood flow and the delay time (Ti) until this was achieved were measured. Using multivariate Cox's regression analyses with mortality from cardiovascular diseases (CVD) and CVD events in the eighth decade as end-points, and maximal blood flow, Ti, distal pulse abnormality and intermittent claudication as possible predictors, high Ti was found to be an independent predictor of both end-points in both sexes. In further multivariate Cox's regression analyses including other possible CVD risk markers, high Ti was of individual predictive value for excess total mortality, excess CVD mortality and excess CVD events in both sexes. It is concluded that high Ti by 133Xenon clearance at the age of 70 is a powerful predictor of future CVD events.
D000368:Aged; D001158:Arteries / Q000503:physiopathology; D002318:Cardiovascular Diseases / Q000453:epidemiology* / Q000401:mortality; D005080:Exercise Test; D005260:Female; D006801:Humans; D007383:Intermittent Claudication / Q000503:physiopathology; D007866:Leg / Q000098:blood supply*; D008297:Male; D009132:Muscles / Q000098:blood supply*; D011379:Prognosis; D011446:Prospective Studies; D012039:Regional Blood Flow; D012044:Regression Analysis; D012737:Sex Factors; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes