[An ischemic-septic disease picture following acute occlusion of the superior mesenteric artery].
The pattern of symptoms which evidences acute mesenterial infarction has been investigated on more than 40 pigs by applying diverse non-surgical therapeutic approaches during transarterial balloon occlusion of the A. mesenterica superior. All animals died within 38 hours, much earlier after central occlusion than after blockage of the peripheral branches of the artery. A convincing delay could only be observed in the group treated by antibiotics. In two groups of clinical patients, 20 before and 28 after the experimental study, we found a significantly better prognosis in the latter group. About 46% of them got an antibiotic treatment immediately after being admitted to hospital. However, recently the time elapsing from the vascular accident to laparotomy has been shorter than in the last two decades. This contributes to better chance of survival in mesenterial ischaemia. Thus, antibiotic protection and early surgical intervention can be considered to be crucial for survival after mesenterial infarction.
D000328:Adult; D000368:Aged; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D007422:Intestines / Q000098:blood supply*; D007511:Ischemia / Q000175:diagnosis*; D007677:Kidney Function Tests; D008297:Male; D008638:Mesenteric Arteries / Q000601:surgery; D008641:Mesenteric Vascular Occlusion / Q000175:diagnosis* / Q000601:surgery; D008875:Middle Aged; D011379:Prognosis; D018805:Sepsis / Q000175:diagnosis* / Q000601:surgery; D013552:Swine
D000900:Anti-Bacterial Agents; D006493:Heparin
Das ischämisch-septische Krankheitsbild nach akutem Vershluss der A. mesenterica superior.