The competitive equilibrium between aluminium and ferric ions for the binding sites of transferrin.
Human transferrin is shown to bind 2 mol of aluminium per mol of protein using spectrophotometric titration. Competitive equilibrium between aluminium and ferric ions for transferrin binding sites is observed, and a value of 2.5 (+/- 0.4) X 10(15) M-1 is found for the apparent binding constant under physiological conditions.
D000535:Aluminum / Q000378:metabolism*; D001665:Binding Sites; D001667:Binding, Competitive; D002412:Cations; D002951:Citrates / Q000378:metabolism; D019343:Citric Acid; D005290:Ferric Compounds / Q000378:metabolism*; D007501:Iron / Q000378:metabolism*; D013056:Spectrophotometry, Ultraviolet; D014168:Transferrin / Q000378:metabolism*
D002412:Cations; D002951:Citrates; D005290:Ferric Compounds; D014168:Transferrin; D019343:Citric Acid; D000535:Aluminum; D007501:Iron