[Effect of different forms of vitamin A and its combination with vitamin E on the peroxidation of lipids].
Effect of vitamins A and E derivatives on Fe-ascorbate dependent peroxidation was studied by means of thiobarbituric acid test in liposomes prepared from egg lecithin. Retinol, incorporated into liposomes at concentration less than 0.1 mol%, increases the lecithin oxidation, retinyl palmitate was less active and alpha-tocopherol inhibited the reaction. Synergistic effect of alpha-tocopherol and retinol was observed. After simultaneous administration of retinol and alpha-tocopherol into liposomes, vitamin A did not accelerate the lecithin oxidation but increased distinctly the inhibitory effect of alpha-tocopherol. This interaction did not occur between retinol and alpha-tocopherol acetate as well as between m-retinyl acetate and alpha-tocopherol. The data obtained suggest that vitamins A and E affect the lipid peroxidation not only via direct participation in free radical oxidation but also due to transformations of biological membranes structure.
D004224:Diterpenes; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism*; D000084562:Retinyl Esters; D014801:Vitamin A / Q000031:analogs & derivatives / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology*
D004224:Diterpenes; D008054:Lipid Peroxides; D008081:Liposomes; D010713:Phosphatidylcholines; D000084562:Retinyl Esters; D014801:Vitamin A; D014810:Vitamin E; C014794:retinol palmitate; C009166:retinol acetate
Vliianie razlichnykh form vitamina A i ego sochetaniia s vitaminom E na perekisnoe okislenie lipidov.