Postpartum regeneration of the guinea pig endometrium: relationship to serum estradiol and progesterone concentrations.
The pattern of cell mitotic activity in the uterus of postpartum, pregnant guinea pigs was correlated with the associated changes in serum progesterone and estradiol levels between days 1-8 of pregnancy. Stromal and glandular epithelial mitotic patterns mimicked the associated fluctuations in serum progesterone and estradiol levels, respectively. No changes in myometrial mitotic activity were observed. The luminal epithelial mitotic index was apparently sensitive to the relative change in the ratio of progesterone-to-estradiol in circulation. These studies indicate that postpartum, endometrial preparation for blastocyst implantation depends on the proper priming of the uterus by both progesterone and estradiol in the guinea pig.
D000818:Animals; D004717:Endometrium / Q000502:physiology*; D004958:Estradiol / Q000097:blood*; D005260:Female; D006168:Guinea Pigs; D008940:Mitotic Index; D009215:Myometrium / Q000166:cytology; D049590:Postpartum Period; D011247:Pregnancy; D011374:Progesterone / Q000097:blood*; D013997:Time Factors
D011374:Progesterone; D004958:Estradiol