Studies on the role of taurine in Friedreich's ataxia.
New studies were undertaken to verify the previous findings of increased urinary excretion of taurine, in the basal state and after challenge with a taurine load, in Friedreich's disease. Particular attention was paid to possible causes of error such as weight, muscle mass, creatine and creatinine excretion, variability with time and appropriate control groups. Although the overall findings were confirmed, their interpretation is open to question because of all these factors of error. Many possibilities must still be further explored to account for the apparent taurine retention defect observed in many cases of Friedreich's disease.
D000293:Adolescent; D000328:Adult; D003401:Creatine / Q000652:urine; D003404:Creatinine / Q000652:urine; D005260:Female; D005621:Friedreich Ataxia / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008297:Male; D009136:Muscular Dystrophies / Q000378:metabolism; D013654:Taurine / Q000097:blood / Q000378:metabolism* / Q000652:urine
D013654:Taurine; D003404:Creatinine; D003401:Creatine