title: [Tissue metallosis of the implant bed as a late complication of metal osteosynthesis].
abstract: Biopsies of soft tissues of 28 patients taken from the region of metallic construction implantation which were in the host for osteosynthesis from 5 months to 4 years were examined histologically, histochemically and electron microscopically. Control biopsis were taken in 4 patients with false joints of long bones 5 months--1 year after the trauma. It is proven that the signs of the metal corrosion destruction are most frequently observed when complex multicomponential metallic implants prepared from heterogeneous metals are used. Corrosion results in the "metallic" tissue response long after the implantation. This is characterized by the formation of dense fibrillar connective tissue, its focal infiltration with fragments of metallic constructions and the products of their destruction in the form of various metal-protein complexes, syderosis, acute or chronic inflammation as a results of corrosion, metallosis and trauma. Metallosis of tissues in the implant bed is to be considered as a late complication of the metallic osteosynthesis.
mesh_terms: D001706:Biopsy; D001842:Bone and Bones / Q000378:metabolism / Q000648:ultrastructure; D003238:Connective Tissue / Q000378:metabolism / Q000648:ultrastructure*; D003343:Corrosion; D005593:Fracture Fixation, Internal / Q000009:adverse effects*; D006651:Histocytochemistry; D006801:Humans; D008670:Metals / Q000009:adverse effects*; D008854:Microscopy, Electron; D011542:Pseudarthrosis / Q000378:metabolism / Q000473:pathology; D013193:Stainless Steel / Q000009:adverse effects; D013997:Time Factors; D014025:Titanium / Q000009:adverse effects
chemical_list: D008670:Metals; D013193:Stainless Steel; D014025:Titanium
vernacular_title: Metalloz tkaneĭ lozha implantata kak pozdnee oslozhnenie metallicheskogo osteosinteza.