Dopaminergic activity is reduced in diabetic rats.
Dopamine synthesis rates in synaptosomes prepared from the striata of alloxan-diabetic rats were considerably lower than in control preparations. Striatal dopamine metabolite levels, after an initial increase, were also reduced at 3 and 6 weeks after alloxan administration. These findings suggest that dopaminergic functioning may be impaired in diabetic rats.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis; D000496:Alloxan; D000818:Animals; D003342:Corpus Striatum / Q000032:analysis / Q000378:metabolism*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D004298:Dopamine / Q000032:analysis / Q000096:biosynthesis*; D006719:Homovanillic Acid / Q000032:analysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013574:Synaptosomes / Q000378:metabolism
D015102:3,4-Dihydroxyphenylacetic Acid; D000496:Alloxan; D004298:Dopamine; D006719:Homovanillic Acid