title: Nitrogen mustard (mechlorethamine) and UVB photocarcinogenesis: a dose response effect.
abstract: The effects of UVB energy and nitrogen mustard (mechlorethamine, HN2) on tumor formation in the hairless mouse skin was examined. Twice weekly applications of HN2 produced tumors in 34% of the mice. In addition, the HN2 treatments plus UVB radiation resulted in a significant acceleration in tumor formation as compared to either carcinogenic stimulus alone. The twice weekly application of HN2 plus UVB exposure was more tumorigenic than UVB plus HN2 applied once a week. Thus a positive carcinogenic dose response was noted. No tumor-suppressing effects were detected in this study.
mesh_terms: D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000209:etiology*; D004305:Dose-Response Relationship, Drug; D008466:Mechlorethamine / Q000008:administration & dosage / Q000009:adverse effects*; D051379:Mice; D008812:Mice, Hairless; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D012878:Skin Neoplasms / Q000139:chemically induced / Q000209:etiology*; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D008466:Mechlorethamine