title: Disseminated xanthosiderohistiocytosis, a variant of xanthoma disseminatum, in a patient with a plasma cell dyscrasia.
abstract: A 57-year-old man was evaluated for infiltrative sclerotic nodules and plaques of the skin, the oral cavity, and the eye. Skin biopsy revealed a proliferation of mature histiocytes and extensive hemosiderin deposition, findings most consistent with xanthoma disseminatum and its variant, disseminated xanthosiderohistiocytosis. The subsequent development of a plasma cell dyscrasia was consistent with previous reports and suggests that xanthoma disseminatum is a marker for plasma cell disorders.
mesh_terms: D006644:Histiocytes / Q000648:ultrastructure; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications; D007074:Immunoglobulin G; D008206:Lymphatic Diseases / Q000150:complications / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000150:complications*; D012867:Skin / Q000473:pathology; D014973:Xanthomatosis / Q000150:complications / Q000473:pathology*
chemical_list: D007074:Immunoglobulin G