Studies of phenylalanine hydroxylase activity in patients with chronic renal failure: the effect of haemodialysis.
The effect of serum from patients with renal failure on phenylalanine hydroxylase activity has been measured in normal individuals, patients with steady-state chronic renal failure and patients undergoing haemodialysis. Significant inhibition of enzyme activity was induced by serum from patients with steady-state chronic renal failure but not from patients undergoing haemodialysis. Inhibitor(s) was readily diffusible in vitro and appeared to have an approximate molecular mass of 800. The results suggest that the low-plasma tyrosine levels observed in patients with chronic renal failure are due, at least in part, to the inhibition of phenylalanine hydroxylase.
D000328:Adult; D000368:Aged; D002850:Chromatography, Gel; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000201:enzymology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010651:Phenylalanine Hydroxylase / Q000037:antagonists & inhibitors / Q000097:blood*; D006435:Renal Dialysis; D014443:Tyrosine / Q000097:blood
D014443:Tyrosine; D010651:Phenylalanine Hydroxylase