Gossypol inhibits Ehrlich ascites tumor cell proliferation.
Neutral gossypol solution injected peritoneally into NMRI mice preimplanted with Ehrlich ascites tumour cell, at a dose of 25-100 micrograms/mouse per day, lengthened the number of survival days of the hosts. This gossypol effect on tumour cell proliferation is concentration dependent. The optimum dose is 100 micrograms. However, at too high a dose, the gossypol caused a body weight loss and the death of the tumour-bearing mice.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006072:Gossypol / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D006072:Gossypol