Effects of nicardipine and other Ca2+-antagonists on catecholamine transport into chromaffin granule membrane vesicles.
Nicardipine (10(-7)-2 X 10(-5) M) inhibited the transport of noradrenaline into chromaffin granule membrane vesicles in a concentration-dependent manner. This inhibitory effect of nicardipine was found to be appreciably stronger than that of other Ca2+-antagonists(diltiazem, nifedipine and verapamil) and was not due to the blockade of Ca2+-channel in the granule membranes.
D000818:Animals; D001692:Biological Transport; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002395:Catecholamines / Q000378:metabolism*; D002417:Cattle; D002837:Chromaffin Granules / Q000378:metabolism*; D002838:Chromaffin System / Q000378:metabolism*; D004110:Diltiazem / Q000494:pharmacology; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000378:metabolism; D009529:Nicardipine; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism
D002121:Calcium Channel Blockers; D002395:Catecholamines; D009529:Nicardipine; D004110:Diltiazem; D009543:Nifedipine; D009638:Norepinephrine