[Acute renal failure caused by clometacin hypersensitivity].
Renal involvement is not frequently observed during therapy with clometacine and its mechanism not fully understood. We report on a case of acute renal failure occurring four times in conjunction with acute hepatitis before the causative effect of clometacine was demonstrated. Drug hypersensitivity was documented by anatomical findings consisting in renal interstitial infiltration by mononuclear cells and eosinophils and by hypereosinophilia, increase in plasma IgE and a positive basophil degranulation test.
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000139:chemically induced / Q000473:pathology; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D007210:Indoleacetic Acids / Q000009:adverse effects*; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology
D007210:Indoleacetic Acids; C017136:clometacin
Insuffisance rénale aiguë par hypersensibilité à la clométacine.