Can pharmacologic hyperprolactinemia and breast-suction induce lactation in women with normal menstrual cycles?
Six women--age range 21/24--with regular ovulatory cycles, voluntarily underwent with L-Sulpiride (100 mg/die) from the 5th to the 19th day of the cycle. On the 13th, 14th and 15th day of therapy breast suction by syringe breast-pump was performed on each woman every 6 hours and for 4' from either breast. Milk secretion was poor and showed no noticeable increase in the three days of breast suction. L-Sulpiride-induced hyperprolactinemia combined with nipple stimulation-induced increased PRL secretion failed to stimulate milk secretion at a level comparable with physiologic lactation in puerperium.
D000328:Adult; D005260:Female; D005687:Galactorrhea / Q000209:etiology*; D006801:Humans; D007774:Lactation; D007775:Lactation Disorders / Q000209:etiology*; D008597:Menstrual Cycle; D049590:Postpartum Period; D011247:Pregnancy; D011388:Prolactin / Q000097:blood*; D013396:Suction; D013469:Sulpiride / Q000494:pharmacology
D013469:Sulpiride; D011388:Prolactin