title: [Immunoprevention of hepatitis B in children of HBsAg-positive pregnant patients].
abstract: Children of hepatitis-B-surface-antigen-positive women are, depending upon the degree of maternal infectivity, exposed to a very different risk of hepatitis B. In the GDR the rate of infectious pregnant women is low. The serious consequences of a perinatal hepatitis B, which very often leads to a chronic course and virus carriers, may widely by prevented by immunoprophylaxis. Various methods for the establishment of a risk are described. The hepatitis-B-surface-antigen screening in 28 127 pregnant woman showed 20 = 0,07% of carriers of findings, 4 out of them HBeAg-positive. From the performance of the passive immunisation in 6 babies of HbeAg-positive mothers and 2 newborn without maternal HBe- or anti-HBe-proof and from the results of the control of 17 children, who were not immunized, when there was an anti-HBe-positiveness or when there was no proof of HBe-markers, result recommendations for practice.
mesh_terms: D002353:Carrier State / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006509:Hepatitis B / Q000276:immunology* / Q000517:prevention & control; D006510:Hepatitis B Antibodies / Q000008:administration & dosage*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006513:Hepatitis B e Antigens / Q000032:analysis; D006801:Humans; D007116:Immunization, Passive / Q000379:methods*; D007223:Infant; D007231:Infant, Newborn; D008111:Liver Function Tests; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology*
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens
vernacular_title: Zur Immunprophylaxe der Hepatitis B bei Kindern von HBsAg-positiven Schwangeren.