title: General anaesthesia with halothane and drug absorption. The effect of general anaesthesia with halothane and diazepam on postoperative gastric emptying in man.
abstract: The effect of general anaesthesia with halothane on postoperative absorption of paracetamol was measured in seven patients, after minor surgery on the extremities. Gastric emptying, estimated indirectly by the rise in serum paracetamol following oral administration of the drug, was significantly delayed after general anaesthesia with halothane compared with gastric emptying when general anaesthesia with halothane was not administered. It was furthermore demonstrated that absorption of paracetamol and therefore gastric emptying were normal or nearly normal when diazepam 15 mg was given orally to the same patients 2 weeks later.
mesh_terms: D000082:Acetaminophen / Q000378:metabolism; D000328:Adult; D000768:Anesthesia, General; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D006221:Halothane / Q000494:pharmacology*; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011184:Postoperative Period; D013997:Time Factors
chemical_list: D004364:Pharmaceutical Preparations; D000082:Acetaminophen; D003975:Diazepam; D006221:Halothane