title: TTX displacement of [H3]-nitrendipine binding in developing spinal cord neurons.
abstract: [3H] Nitrendipine binding was partially blocked by the presence of tetrodotoxin in developing spinal cord neurons. In young cultures, 1 micron tetrodotoxin displaced 29% and 26% of [3H] nitrendipine binding from the high and low affinity binding sites, respectively. In one month old cultures, tetrodotoxin had no effect on [3H] nitrendipine binding. The interaction between tetrodotoxin and nitrendipine in young cultures suggests ligand binding site similarities during development.
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D002478:Cells, Cultured; D005260:Female; D051379:Mice; D009474:Neurons / Q000378:metabolism*; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000378:metabolism; D009568:Nitrendipine; D011247:Pregnancy; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism*; D013779:Tetrodotoxin / Q000378:metabolism*; D013997:Time Factors
chemical_list: D013779:Tetrodotoxin; D009568:Nitrendipine; D009543:Nifedipine