title: Ejection fraction and regional wall motion at rest and during stress in the diagnosis of coronary artery disease.
abstract: Stress radio nuclide ventriculography is used to determine ejection fraction and changes in regional wall motion for the detection of ischemia-induced left ventricular dysfunction in patients with coronary artery disease. We have evaluated the relative sensitivity of regional wall motion and of ejection fraction during hand-grip and cold pressor test, in 21 patients with angina pectoris and documented coronary artery disease at angiography. Regional wall motion appeared a more sensitive index than global ejection fraction producing only two false negative cases. Ejection fraction showed great variability among the patients during both hand-grip and cold pressor test. This might be explained by the fact that both tests do not produce a sufficient degree of ischemic stress on the left ventricle. Hand-grip and cold pressor tests appear useful alternative to dynamic exercise in the diagnosis of coronary artery disease being also safe and simple to perform.
mesh_terms: D000328:Adult; D000368:Aged; D003080:Cold Temperature; D003327:Coronary Disease / Q000175:diagnosis* / Q000503:physiopathology; D005069:Evaluation Studies as Topic; D005260:Female; D006352:Heart Ventricles / Q000000981:diagnostic imaging / Q000503:physiopathology; D006801:Humans; D007537:Isometric Contraction; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D011877:Radionuclide Imaging; D012146:Rest; D013318:Stroke Volume