title: Plasma protein binding interaction of prednisone and prednisolone.
abstract: The plasma protein binding interaction of prednisone and prednisolone were characterized by equilibrium dialysis. Prednisone and prednisolone are bound equally but weakly to human albumin (affinity constant, K approximately equal to 1 X 10(3) M-1). Transcortin affinity for prednisolone is 10-fold greater (51.3 X 10(6) M-1) than that for prednisone (4.3 X 10(6) M-1). In competition under pharmacologic conditions, prednisolone inhibits prednisone binding to transcortin producing linear binding averaging 55%. Prednisone does not affect prednisolone binding and does not complicate pharmacokinetic studies of the latter.
mesh_terms: D001667:Binding, Competitive; D001798:Blood Proteins / Q000378:metabolism*; D006801:Humans; D011239:Prednisolone / Q000097:blood*; D011241:Prednisone / Q000097:blood*; D011485:Protein Binding
chemical_list: D001798:Blood Proteins; D011239:Prednisolone; D011241:Prednisone