[Acid-soluble CoA and free amino acid levels in the liver of pantothenic acid-deficient albino rats after separate and combined administration of panthotenic acid and cysteine].
The feeding of white rats with a synthetic diet deprived of pantothenic acid (PAA) for 10 weeks led to a decrease in the content of acid-soluble CoA (AS-CoA) and to an increase in the liver taurine and glycine concentration. One hour after pantothenate injection (30 mg/kg) to PAA-deficient animals the level of AS-CoA rose by 96%, whereas after administration of an equimolar dose of cystein by 63%. Combined administration of CoA precursors did not result in summation of the effects. In all the cases of cystein injections, substantial changes were recorded in the structure of the liver amino acid pool, which were less marked if cystein was combined with pantothenate. It is assumed that the metabolism of cystein, glycine and, probably, that of alanine may depend on the changes in the CoA pool in hepatocytes.
D000143:Acids / Q000494:pharmacology; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D003065:Coenzyme A / Q000378:metabolism*; D003545:Cysteine / Q000008:administration & dosage; D004338:Drug Combinations; D008099:Liver / Q000378:metabolism*; D010205:Pantothenic Acid / Q000008:administration & dosage / Q000172:deficiency*; D051381:Rats; D012995:Solubility
D000143:Acids; D000596:Amino Acids; D004338:Drug Combinations; D010205:Pantothenic Acid; D003545:Cysteine; D003065:Coenzyme A
Uroven' kislotorastvorimogo KoA i svobodnykh aminokislot pecheni pantotenatdefitsitnykh belykh krys pri razdel'nom i sochetannom vvedenii pantotenata i tsisteina.