[Regulation of the excisional repair system in in vitro-cultured human cells by measles viruses depending on their attenuation].
The effect of measles viruses (attenuated strain L-16 and virulent strain Edmonston) was studied in human cells (line L-41) according to the criteria of repair: excision of thymine dimers, repair replication of DNA and resynthesis of DNA breaks induced by UV-irradiation. Reproduction of attenuated measles virus in cells was accompanied with stimulation of excision of thymine dimers and repair replication of DNA in contradistinction to mild virus. This phenomenon depended on multiplicity of infection.
D002460:Cell Line; D004260:DNA Repair / Q000528:radiation effects; D004261:DNA Replication / Q000528:radiation effects; D006801:Humans; D008457:Measles / Q000378:metabolism / Q000382:microbiology; D008459:Measles virus / Q000472:pathogenicity*; D011740:Pyrimidine Dimers / Q000528:radiation effects; D013997:Time Factors; D014466:Ultraviolet Rays; D014774:Virulence; D014776:Virus Cultivation
D011740:Pyrimidine Dimers
Reguliatsiia ékstsizionnoĭ sistemy reparatsii v kletkakh cheloveka, kul'tiviruemykh in vitro, virusami kori v zavisimosti ot ikh attenuatsii.