The mode of inheritance of psoriasis: evidence for a major gene as well as a multifactorial component and its implication for genetic counselling.
Complex segregation analysis of Lomholt's family data on psoriasis on the Faroe Islands gave evidence for an additive major gene with gene frequency of 0.07 and penetrance 0.12 and 0.44 in the heterozygote and in the homozygote, respectively. In addition, there was a multifactorial component with heritability 0.87. The implications of these findings for genetic counseling are discussed and analytical risk figures are presented for chosen pedigrees.
D000367:Age Factors; D005260:Female; D005787:Gene Frequency; D005799:Genes, Dominant; D005817:Genetic Counseling; D006801:Humans; D008297:Male; D010375:Pedigree; D011565:Psoriasis / Q000175:diagnosis / Q000235:genetics*