[Protective action of antioxidant preparations on the development of experimental allergic encephalomyelitis in guinea pigs].
The authors studied the action of combined tocopherol, lithium hydroxybutyrate and pyridoxal phosphate on the development of experimental allergic encephalomyelitis (EAE) in guinea-pigs. The use of the combined drug from the first days of immunization with encephalitis-inducing material prevented the development of EAE, activation of lipid peroxidation (LPO), and the appearance of the blood serum neurotropic activity. Administration of the combined drug starting from the 7th day after immunization appeared ineffective as was the administration of each drug alone, starting from the first days of immunization. The data obtained support an important role of LPO activation for the pathogenesis of the neuroallergic process.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology / Q000378:metabolism / Q000517:prevention & control*; D006168:Guinea Pigs; D006885:Hydroxybutyrates / Q000627:therapeutic use; D008054:Lipid Peroxides / Q000378:metabolism; D008094:Lithium / Q000627:therapeutic use; D009942:Organometallic Compounds; D010544:Peroxidases / Q000097:blood; D011732:Pyridoxal Phosphate / Q000627:therapeutic use; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use
D000975:Antioxidants; D006885:Hydroxybutyrates; D008054:Lipid Peroxides; D009942:Organometallic Compounds; D014810:Vitamin E; D011732:Pyridoxal Phosphate; C022826:lithium hydroxybutyrate; D008094:Lithium; D010544:Peroxidases
Protektivnoe deĭstvie preparatov antioksidantnogo deĭstviia na razvitie éksperimental'nogo allergicheskogo éntsefalomielita u morskikh svinok.