title: Aging, regional cerebral blood flow, and neuropsychological functioning.
abstract: Previous studies found changes in regional cerebral blood flow (rCBF) patterns related to both age and various cognitive tasks. However, no study has yet demonstrated a relationship between rCBF and performance on the Luria-Nebraska Neuropsychological Battery (LNNB) in an elderly group. Seventy-nine elderly volunteers (56-88 years old), both healthy and demented, underwent the 133xenon inhalation rCBF procedure and were given the LNNB. The decrements in the gray-matter blood flow paralleled decrements in performance on the LNNB. Using partial correlations, a significant proportion of shared variance was observed between gray-matter blood flow and the LNNB scales. However, there was much less of a relationship between white-matter blood flow and performance on the LNNB. This study suggests that even within a restricted age sample rCBF is related in a global way to neuropsychological functioning.
mesh_terms: D000368:Aged; D000375:Aging; D002560:Cerebrovascular Circulation; D003071:Cognition / Q000502:physiology*; D005260:Female; D006801:Humans; D008182:Luria-Nebraska Neuropsychological Battery; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D012039:Regional Blood Flow; D014980:Xenon Radioisotopes
chemical_list: D014980:Xenon Radioisotopes