[Effect of hydroxyurea on the number of hematopoietic stem cells, stromal cell precursors and cell precursors of thymus lymphoid tissue in the bone marrow of mice during aging].
The concentration of hemopoietic stem cells (colony-forming cells in the spleen - CFC-S) decreases in the bone marrow of CBA mice during ageing, whereas the concentration of precursors for stromal fibroblasts (colony-forming cells for fibroblasts-CFC-F) increases. The total numbers of nucleated cells, CFC-S and CFC-F in the bone marrow of old mice essentially increase. Hydroxyurea, administered in vivo, does not effect the concentration of CFC-S, but it increases CFC-F concentration in the bone marrow of mice. Hydroxyurea produces just the same suppressive effect on the numbers of nucleated cells, CFC-S and CFC-F in the mice of different ages, and stimulates the capacity of bone marrow donors to repopulate the thymus of the irradiated young recipients.
D000375:Aging / Q000187:drug effects; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D002452:Cell Count; D003114:Colony-Forming Units Assay; D005260:Female; D006168:Guinea Pigs; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006918:Hydroxyurea / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D013234:Stem Cells / Q000187:drug effects*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects*; D013997:Time Factors
D006918:Hydroxyurea
Vliianie oksimocheviny na soderzhanie stvolovykh krovetvornykh kletok, stromal'nykh kletok-predshestvennikobv i kletok-predshestvennikov dlia limfoidnoĭ tkani timusa v kostnom mozge mysheĭ pri starenii.