title: Chromosomal assignment of two murine genes controlling susceptibility to spleen focus formation by Rauscher leukemia virus.
abstract: Two murine genes affecting susceptibility to spleen focus formation by RLV were assigned to chromosomes. The gene Rv-2, which controls susceptibility to spleen focus formation, was assigned to chromosome 9, and closely linked to the Fv-2 gene, by using the two congenic strains B10.C(47N)/Sn and B6.C-H-7b/By. These congenic strains, which were previously shown to carry the BALB/cJ allele for susceptibility to FLV on chromosome 9, were also susceptible to RLV, as determined by number of foci on the spleens of infected mice. A second gene which contributes to the susceptibility to spleen focus formation by RLV was assigned to the X chromosome because hemizygous male offspring of crosses between resistant-strain females and susceptible-strain males (C57BL/6J X CBA/Lac) showed significantly lower numbers of foci/spleen than the female littermates and than the offsprings, males and females, of the reciprocal cross (CBA/Lac X C57BL/6J). We suggest this gene be called Rv-3.
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004198:Disease Susceptibility; D005260:Female; D008040:Genetic Linkage; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000235:genetics*; D009857:Oncogenes; D011925:Rauscher Virus / Q000235:genetics*; D013045:Species Specificity; D013154:Spleen / Q000382:microbiology*; D014960:X Chromosome