Effect of bromocriptine, a dopamine receptor agonist, on the experimentally induced gastric ulcers in albino rats.
The effect of bromocriptine, a dopamine receptor agonist, has been studied on the aspirin, phenylbutazone and reserpine induced gastric ulcers in rats. A single dose of bromocriptine 4 mg/kg s.c. produced a significant exacerbation of gastric ulcers induced by all the three ulcerogenic drugs, whereas in the same dose administered once daily for 5 consecutive days, it produced a marked protective effect in all the models. A review of the literature shows that different mechanisms may be involved in the opposite effects of acutely and chronically administered bromocriptine observed in this study. The study also points towards a role of dopamine in the pathogenesis of gastroduodenal ulceration.
D000818:Animals; D001241:Aspirin; D001971:Bromocriptine / Q000494:pharmacology*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects; D008297:Male; D010653:Phenylbutazone; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine; D013276:Stomach Ulcer / Q000139:chemically induced / Q000473:pathology*
D001971:Bromocriptine; D012110:Reserpine; D010653:Phenylbutazone; D001241:Aspirin