Inhibitory effect of tumour cells on leukocyte motility.
Hep-2 cells inhibit the random migration of human polymorphonuclear leukocytes in a tumour cell-leukocyte microenvironmental model, which is a special form of co-migration. The inhibition is indomethacin-sensitive. It is very likely that prostaglandins, produced as a consequence of interaction between tumour cells and leukocytes, are the mediators of this phenomenon. The tumour-induced inhibition of leukocyte motility may represent a tumour-protective mechanism.
D002460:Cell Line; D002465:Cell Movement; D046508:Culture Techniques; D006801:Humans; D007165:Immunosuppression Therapy; D007213:Indomethacin / Q000494:pharmacology; D009504:Neutrophils / Q000502:physiology*; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011453:Prostaglandins / Q000502:physiology; D011458:Prostaglandins E / Q000096:biosynthesis
D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D011458:Prostaglandins E; D007213:Indomethacin