title: A health index to evaluate clinically a beta-hemolytic streptococcal infectious disease model in the horse.
abstract: Quantification of the clinical manifestations of a disease has been a serious problem particularly as related to clinical trials or drug efficacy studies. Historically, this quantification has been limited to categorizing each patient into one of three or four groups, e.g. worse, no improvement, improved. This problem becomes serious when an investigation utilizes an experimentally induced animal disease model. A health index, which quantifies the clinical state of horses which have an experimentally induced beta-hemolytic streptococcal infection, is described. Aspects of experimental design and statistical analysis are also discussed in relationship to the use of the index for drug efficacy studies.
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006734:Horse Diseases / Q000188:drug therapy / Q000382:microbiology*; D006736:Horses / Q000502:physiology; D008826:Microbial Sensitivity Tests; D010400:Penicillin G / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D013290:Streptococcal Infections / Q000503:physiopathology / Q000662:veterinary*; D013291:Streptococcus / Q000187:drug effects
chemical_list: D010400:Penicillin G