[Effect of sodium oxybutyrate on metabolic indices in ischemic hypoxia of muscle tissue].
It has been demonstrated in experiments on rats with an ischemized hind limb that sodium hydroxybutyrate promoted activation of glucose-6-phosphate dehydrogenase of the pentosophosphate cycle, prevented the changes in the content of lactic acid and activity of lactate dehydrogenase in the ischemized muscle, interfered with the development of metabolic acidosis during devascularization of the ischemized limb.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006614:Hindlimb / Q000098:blood supply; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D007511:Ischemia / Q000188:drug therapy* / Q000201:enzymology; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009132:Muscles / Q000098:blood supply* / Q000201:enzymology; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D012978:Sodium Oxybate / Q000627:therapeutic use*; D013997:Time Factors
D006885:Hydroxybutyrates; D012978:Sodium Oxybate; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase
Vliianie natriia oksibutirata na nekotorye pokazateli metabolizma pri ishemicheskoĭ gipoksii myshechnoĭ tkani.