title: Hydrostatic reduction of childhood intussusception. The role of adjuvant glucagon medication.
abstract: The value of glucagon to facilitate hydrostatic reduction of childhood ileo-colic intussusception was tested in a series of 188 consecutive cases. Sixty-nine patients selected at random received 0.05 mg glucagon/kg body weight intramuscularly before attempts at reduction were started. The rate of successfully accomplished reductions was 84 per cent in the test group and 76 per cent in the control group (not significant). The time for accomplished reduction was approximately equal in the two groups. After 3 unsuccessful attempts at hydrostatic reduction patients in the control group received glucagon. The subsequent attempt at reduction proved successful in slightly more than every second case. No complications occurred. In general, glucagon was not found to improve the rate of employed reductions nor on the time necessary for reduction to take place. The investigation indicated, however, that there may be a limited benefit of adjuvant medication of glucagon. After two unsuccessful barium enemas glucagon administration is therefore recommended before a third attempt at reduction is performed.
mesh_terms: D001466:Barium Sulfate / Q000627:therapeutic use*; D002675:Child, Preschool; D004733:Enema / Q000379:methods; D005934:Glucagon / Q000008:administration & dosage*; D006801:Humans; D006874:Hydrostatic Pressure; D007077:Ileal Diseases / Q000628:therapy*; D007223:Infant; D007231:Infant, Newborn; D007422:Intestines / Q000187:drug effects; D007443:Intussusception / Q000628:therapy*; D009126:Muscle Relaxation / Q000187:drug effects
chemical_list: D001466:Barium Sulfate; D005934:Glucagon