title: [Various methods of overcoming secondary resistance to treatment developing in relation to adaptation to psychotropic drugs during long-term treatment (clinico-experimental study)].
abstract: Clinical and experimental studies into the phenomenon of adaptation to neuroleptic agents and into the methods of its overcoming were carried out. An experimental study of the long-term administrations of haloperidol revealed the formation of adaptation to the drug which can be overcome by a zigzag-like sharp elevation of the dosage followed by rapid reduction to the baseline level. The trial of this method under clinical conditions showed that it was expedient to use on a large scale the experimental findings on the specific features of the formation and prevention of the secondary therapeutic resistance.
mesh_terms: D000328:Adult; D000818:Animals; D002375:Catalepsy / Q000139:chemically induced; D003342:Corpus Striatum / Q000378:metabolism; D004195:Disease Models, Animal; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D006220:Haloperidol / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D051379:Mice; D011954:Receptors, Dopamine / Q000378:metabolism; D012563:Schizophrenia, Paranoid / Q000188:drug therapy*; D013134:Spiperone / Q000378:metabolism; D014268:Trifluoperazine / Q000627:therapeutic use
chemical_list: D011954:Receptors, Dopamine; D014268:Trifluoperazine; D013134:Spiperone; D006220:Haloperidol
vernacular_title: Nekotorye metody preodoleniia vtorichnoĭ terapevticheskoĭ rezistentnosti, formiruiushcheĭsia v sviazi s adaptatsieĭ k psikhotropnym sredstvam pri dlitel'nom lechenii (kliniko-éksperimental'noe issledovanie).