Dynamic radioisotope bone imaging as a noninvasive indicator of canine tibial blood flow.
The relative values of dynamic and static bone imaging with hydroxymethylenediphosphonate technetium 99m (99mTc HDP) as an indicator of bone blood flow was investigated in the tibia of mature dogs. The dynamic bone scan consisted of 60 1-s images formed after the intravenous injection of 99mTc HDP, and the static bone scan was a 45-min uptake image. Blood flow to the tibia was determined by using radioactively labeled microspheres. Studies were carried out in control dogs, in dogs in which blood flow was increased in one leg with ATP, and in dogs in which blood flow was decreased in one leg with norepinephrine. A significant (p less than 0.001) linear relationship between the dynamic scan values and bone blood flow was found at a wide range of blood flow rates. When blood flow increased by more than 50%, the effects of "diffusion limitation" were seen in the static scans: increase in tracer uptake was disproportionately small for a significant increase in blood flow. There is no method currently available for estimating bone blood flow by a noninvasive technique. The method described here may be useful for providing a semiquantitative measure of bone blood flow. This improved versatility of bone imaging may have a role in the management of osteomyelitis or complicated fractures, or in assessing the viability of vascularized bone grafts.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D001783:Blood Flow Velocity; D004164:Diphosphonates; D004285:Dogs; D008863:Microspheres; D009638:Norepinephrine / Q000494:pharmacology; D011877:Radionuclide Imaging; D012039:Regional Blood Flow / Q000187:drug effects; D013667:Technetium; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives*; D013977:Tibia / Q000098:blood supply* / Q000000981:diagnostic imaging
D004164:Diphosphonates; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013667:Technetium; D000255:Adenosine Triphosphate; D009638:Norepinephrine; D013669:Technetium Tc 99m Medronate