Long-term controlled navel administration of testosterone.
Male fertility has reportedly been regulated by the long-term, continuous administration of testosterone. To deliver the testosterone at a controlled rate for a month or longer, a bandage-type, testosterone-releasing, disk-shaped device was developed. In vitro drug elution studies demonstrated that a constant release profile of testosterone was achieved. In vivo studies in rhesus monkeys with the medicated device directly overlaying the navel for 46 d, yielded a fairly steady plasma level and also a constant urinary excretion rate for 32 d. A greater systemic bioavailability (more than twofold) was achieved as compared with drug disposition directly onto the navel or via the placebo device (i.e., drug is deposited onto the prefabricated placebo device). A fairly constant cumulative urinary recovery profile was achieved for longer than 1 month, in which greater than 90% of the dose was administered. The in vitro and in vivo relationship was analyzed and discussed.
D000287:Administration, Topical; D000818:Animals; D003692:Delayed-Action Preparations; D008253:Macaca mulatta; D012869:Skin Absorption; D013739:Testosterone / Q000008:administration & dosage* / Q000378:metabolism; D013997:Time Factors; D014472:Umbilicus
D003692:Delayed-Action Preparations; D013739:Testosterone