[High adrenaline sensitivity of the mitochondrial processes in the mucosa of the small intestine in rats].
Higher adrenalin sensitivity of mitochondrial processes in the small intestinal mucosa compared to that in liver mitochondria, was revealed under specially devised conditions of work with isolated mitochondria retaining their natural properties. Fifteen minutes after intraperitoneal injection of adrenalin into rats in a dose of 5 micrograms/100 bw an increase in Ca2+ capacity was seen only in intestinal mucosa mitochondria. The adrenalin-induced activation of oxidative phosphorylation was more remarkable in intestinal than in liver mitochondria at the initial stages of adrenalin action. The effect of adrenalin was completely reversed by the beta-blocker propranolol only in liver mitochondria. After 3 hours the adrenalin-induced activation of phosphorylation in the mitochondria ceases, whereas in the small intestinal mucosa it still persists.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000378:metabolism; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D011433:Propranolol; D004837:Epinephrine
Vysokaia chuvstvitel'nost' k adrenalinu mitokhondrial'nykh protsessov v slizistoĭ obolochki tonkoĭ kishki krysy.