Morphometric analysis of platelets in Bernard-Soulier syndrome: size and configuration in patients and carriers.
Quantitative ultrastructural morphometric analysis has been carried out on thin sections of platelets from two Bernard-Soulier sisters and their parents. Measurements were made for the major and minor axes, axial ratios, cross-sectional circumference and cross-sectional area. Platelets were collected either into CPD anticoagulant or directly into glutaraldehyde. The results confirm that Bernard-Soulier platelets are significantly larger than normals (p less than 0.05) in all the parameters mentioned and indicate (I) that the morphology of platelets from Bernard-Soulier patients is affected by the presence of anticoagulant, and (II) a more spherocytic configuration is characteristic of Bernard-Soulier disease both in patients and carriers.
D001778:Blood Coagulation Disorders / Q000097:blood* / Q000235:genetics; D001791:Blood Platelet Disorders / Q000097:blood* / Q000235:genetics; D001792:Blood Platelets / Q000473:pathology*; D006579:Heterozygote; D006801:Humans; D013577:Syndrome