title: Early carotid endarterectomy in patients with small, fixed neurologic deficits.
abstract: Patients who have sustained a large hemispheric stroke are not candidates for early carotid endarterectomy, but there is less agreement regarding the role of carotid endarterectomy in patients with small, fixed neurologic deficits. Accepted practice in many centers is to wait 4 to 6 weeks after the onset of the deficit before proceeding with carotid endarterectomy because of the fear that early revascularization will increase the size of the infarct. Earlier endarterectomy, however, in patients with significant residual ipsilateral carotid territory at risk may prevent repeated infarctions. For the past 5 years our approach to patients with a small stable stroke and significant stenosis (greater than 75%) has been prompt ipsilateral endarterectomy. Of the 337 carotid endarterectomies at our institution since 1979, a subset of 28 patients with hemodynamically significant carotid lesions presented with a small, fixed stroke. The period of time between the appearance of the stroke and carotid endarterectomy averaged 11 days, but 53% of patients were operated on within 7 days of the onset of symptoms. Selective shunting based on intraoperative EEG monitoring was utilized and 40% of the 28 patients required shunts. Operative mortality consisted of one death from a pulmonary embolus, and no patient sustained a new postoperative deficit. Long-term follow-up was available for 96% of patients over a mean of 2 years. During this time two new neurologic events occurred: one fatal stroke and one transient deficit. This experience indicates that patients with small, fixed neurologic deficits who continue to have carotid territory at risk may safely undergo carotid endarterectomy without waiting 4 to 6 weeks.
mesh_terms: D000368:Aged; D002340:Carotid Artery Diseases / Q000601:surgery*; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000517:prevention & control; D002561:Cerebrovascular Disorders / Q000601:surgery*; D003251:Constriction, Pathologic; D004569:Electroencephalography; D004691:Endarterectomy; D005260:Female; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic; D012189:Retrospective Studies; D012306:Risk; D013997:Time Factors; D014057:Tomography, X-Ray Computed