Are flaviviruses again active in Mali?
Using a hemagglutinating yellow fever antigen, a serologic investigation was done on 1237 blood samples collected between 1979 and 1983 in five regions of Mali. The results showed that the percentage of positive reactions (greater than 1:10) was higher in the sera of mothers than in their new borns (24.8 versus 12.4). In young children (6 months to 3 years old) the percentages of positive sera varied between 4.4 and 9.6. The values were much higher for persons between 15 to 70 years (28.3% to 43.7%). The presence of high antibody titers in sera of adults, the occurrence of seroconversion in young children (less than 1:10 to 1:40) are arguments for supposing that yellow fever virus or other flaviviruses were active in Mali in the period of our investigation.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D002980:Climate; D003716:Dengue Virus / Q000276:immunology; D005260:Female; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008302:Mali; D008875:Middle Aged; D014902:West Nile virus / Q000276:immunology; D015005:Yellow fever virus / Q000276:immunology*
D000914:Antibodies, Viral