Effects of various levels of dietary calcium during pregnancy on maternal calcium utilization and fetal growth in rats.
The effects of calcium-free and normal (0.6%) and high (1.0%) calcium diets on the transfer of calcium from pregnant mothers to fetuses were investigated by balance experiments. Pregnant rats receiving calcium-free, normal and high calcium diets ate totals of 353, 324 and 280 g of the diet, respectively, during pregnancy, and the food consumption of the latter two groups decreased near term. The group on calcium-free diet was able to maintain pregnancy and produce normal fetuses by using calcium resorbed from the dam's bones. The calcium retentions due to pregnancy in rats on normal and high calcium diets were 116 and 128 mg, respectively, during the first 15 days, and -9 and -109 mg, respectively, during the last 6 days of pregnancy. Fetuses contained about 130 mg of calcium at term and most of this calcium was supplied from the dam's bones, in which extra calcium were retained during early-mid pregnancy. Unexpectedly, the true rate of calcium absorption was appreciably lower during late pregnancy than during early-mid pregnancy in both dietary groups. Thus, extra calcium retention during early-mid pregnancy seemed to be physiological adaptation to a decrease in either food consumption or calcium absorption during late pregnancy. Phosphorus absorption and its balance were examined in relation with the dietary calcium levels.
D000818:Animals; D001835:Body Weight; D001842:Bone and Bones / Q000378:metabolism; D002136:Calcium, Dietary / Q000378:metabolism / Q000494:pharmacology*; D005314:Embryonic and Fetal Development; D005247:Feeding Behavior / Q000502:physiology; D005260:Female; D005865:Gestational Age; D007408:Intestinal Absorption; D008431:Maternal-Fetal Exchange; D010758:Phosphorus / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D011919:Rats, Inbred Strains
D002136:Calcium, Dietary; D010758:Phosphorus