[Effect of x-rays on the intracellular transport of thymidine in human lymphocytes stimulated by phytohemagglutinins].
The effect of X-irradiation on thymidine transport in human lymphocytes PHA stimulated was investigated. Mediated transport sistem, the predominant mechanism at low extracellular concentration of thymidine (less than 10(-7) M) in the medium is highly radiosensitive. The transport sistem was damaged considerably by high doses of X-rays (at least until 10 Krad); the decrease of thymidine uptake was a function of the time of incubation after irradiation. It suggest that repair mechanisms are not involved at high doses of X-rays within 120 minutes of incubation.
D001693:Biological Transport, Active / Q000528:radiation effects; D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000528:radiation effects*; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects; D010835:Phytohemagglutinins / Q000494:pharmacology; D013936:Thymidine / Q000097:blood*; D013997:Time Factors
D010835:Phytohemagglutinins; D013936:Thymidine
Effetto dei raggi X sul trasporto intracellulare della timidina in linfociti umani PHA stimolati.