Continuous naloxone infusion for opiate poisoning in infancy.
I report the successful treatment of severe infantile opiate poisoning with continuous naloxone infusions. Two infants, one aged 12 months and the other 3 days, were intoxicated with 100 mg normethadone and 5 mg morphine, respectively. They were given constant infusions of 0.04 and 0.16 mg/kg/hr for 2 1/2 and 5 days, respectively. Continuous naloxone infusion should be considered in the management of severe opiate poisoning.
D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007263:Infusions, Parenteral; D008297:Male; D008614:Meperidine / Q000506:poisoning*; D008691:Methadone / Q000031:analogs & derivatives* / Q000506:poisoning; D009270:Naloxone / Q000008:administration & dosage*; D011041:Poisoning / Q000188:drug therapy*
D009270:Naloxone; D008614:Meperidine; C005845:normethadone; D008691:Methadone