[Renal blood flow in rabbit using hydrogen clearance method].
The local renal blood flow in rabbits was determined by means of hydrogen gas clearance. Simultaneously, to clarify intrarenal redistribution during ischemic renal failure, renal vessels were occluded for some period. Namely, the rabbits were divided into three groups according to the duration of warm ischemia, which was 30, 60 and 120 minutes. The cortical and paramedullary blood flow were 215.0 +/- 29.8 and 145.6 +/- 26.3 ml/min/100 g, respectively, in the control group. In the three ischemic groups, each renal blood flow was only reduced by about 30% after 10 minutes following release of occlusion. In cases of ischemia of 30 or 60 minutes, no distinct intrarenal redistribution was seen. However, in 120 minute ischemia a slight decrement of cortical blood flow occurred after 40 minutes following release of clamp. Hydrogen gas clearance can be used to measure regional blood flow repeatedly. This method should be clinically applicable.
D058186:Acute Kidney Injury / Q000503:physiopathology; D000818:Animals; D001811:Blood Volume Determination / Q000379:methods*; D006859:Hydrogen / Q000032:analysis*; D011817:Rabbits; D012079:Renal Circulation
D006859:Hydrogen