Lack of tubal occlusion by intrauterine quinacrine and tetracycline in the primate.
The effects of slow- and fast-releasing quinacrine pellets and tetracycline tablets on the genital tracts of 20 cynomolgus monkeys was evaluated. After surgical implantation of the pellets, the primates were observed for three months. No signs of toxic effects to the drugs were observed during the three-month period and on autopsy. Histopathological evaluation of the fallopian tubes, cervix, ovaries and uterus (except the endometrium) indicated they were all within normal limits. In no case were the uterotubal junctions obstructed. Endometrial changes were more frequent for quinacrine-treated monkeys. The results of the study point to the need for additional research regarding the optimal dose and duration of quinacrine administration.
D000818:Animals; D003692:Delayed-Action Preparations; D004717:Endometrium / Q000187:drug effects; D005187:Fallopian Tubes / Q000187:drug effects*; D005260:Female; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008252:Macaca fascicularis; D011796:Quinacrine / Q000494:pharmacology*; D013246:Sterilization, Tubal / Q000379:methods*
D003692:Delayed-Action Preparations; D011796:Quinacrine