The influence of potassium loading on the pressor and metabolic effects of 9-alpha-fluoro-cortisol in sheep.
9 alpha-Fluorocortisol (9 alpha FF) is an analogue of cortisol with 'mineralocorticoid', 'glucocorticoid' and 'hypertensinogenic' activity. 9 alpha FF was infused at 2 mg/day for 5 days to sheep receiving a normal Na intake (100 mmol/d) and a high K intake (congruent to 800 mmol/d). K loading modified the Na retaining effects of 9 alpha FF but had no effect on the development of the hypertension. These experiments suggest that the effects of K loading on the development of 9 alpha-FF hypertension are not related simply to the effects that K has on modifying the Na retaining effects of the steroid.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D003348:Cortisone / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D011188:Potassium / Q000097:blood; D011189:Potassium Chloride / Q000494:pharmacology*; D012756:Sheep; D012964:Sodium / Q000097:blood; D014882:Water-Electrolyte Balance / Q000187:drug effects
D011189:Potassium Chloride; C033001:9-fluorocortisone; D012964:Sodium; D011188:Potassium; D003348:Cortisone