Biliary elimination of apalcillin in humans.
Apalcillin was administered intravenously as a single 1-g dose on day 8 after surgery to 10 cholecystectomized patients with T-tube drainage. A peak of 2,093 +/- standard error of the mean 859 micrograms/ml of bile was attained at 3 h after dosage. Biliary recovery over a 12-h period amounted to 12.2% of the dose. In 20 patients undergoing biliary surgery, apalcillin concentrations 1 h after a 1-g dose were 65.5 +/- 5.0, 3,680 +/- 551, and 2,552 +/- 627 micrograms/ml in serum, choledochal bile, and gallbladder bile, respectively.
D000667:Ampicillin / Q000031:analogs & derivatives* / Q000378:metabolism; D001646:Bile / Q000378:metabolism*; D002763:Cholecystectomy; D006801:Humans; D007700:Kinetics; D009287:Naphthyridines
D009287:Naphthyridines; C012122:apalcillin; D000667:Ampicillin