title: Is progression of coronary artery disease occurring at bouts or as a continuous process? Serial cineangiographic studies in 44 patients.
abstract: In order to assess if coronary artery disease progression occurs as a slow, continuous process or at bouts, the coronary angiograms of 44 patients catheterized three times were reviewed. A previously developed logistic model, taking into account time interval between the angiograms, age, occurrence of unstable angina, and extent score of coronary artery disease, was used to compute a probability of progression from the second to the third angiogram. Two groups of patients were considered: those with (n = 15) and those without (n = 29) progression from the first to the second angiogram (PROGRESSION 1-2). A simulation provided in each group the distribution of the expected number of patients with progression from the second to the third catheterization. In the group without PROGRESSION 1-2, the observed number of progressions from the second to the third angiogram was in agreement with the expected one. However, in the group with PROGRESSION 1-2, the progression from the second to the third angiogram was more frequent than expected (p = 0.068). These results suggest that, in many patients, coronary artery disease progression is continuous over several years.
mesh_terms: D002932:Cineangiography; D003201:Computers; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D006801:Humans; D008955:Models, Cardiovascular; D011336:Probability; D013997:Time Factors