A fresh look at iontophoresis.
The rate of penetration of fluorescein and gentamicin ions into the anterior chamber of the rabbit was increased more than 100-fold by the passage of 1 mamp; the amount of drug that penetrates is better controlled by iontophoresis than by instillation. The potential value, the safety and the limitations of this procedure are discussed, and a theoretical basis for the increase is provided. Practical methods of using iontophoresis in the clinic are described. A 30-s application should result in a therapeutic level of the antibiotic in the anterior segment over a 12-hour period in eyes with an intact epithelium.
D000818:Animals; D000867:Anterior Chamber / Q000032:analysis / Q000378:metabolism; D001082:Aqueous Humor / Q000032:analysis / Q000378:metabolism; D003315:Cornea / Q000032:analysis / Q000378:metabolism; D005260:Female; D019793:Fluorescein; D005452:Fluoresceins / Q000032:analysis / Q000378:metabolism; D005839:Gentamicins / Q000032:analysis / Q000378:metabolism; D006801:Humans; D007478:Iontophoresis / Q000009:adverse effects / Q000379:methods; D008962:Models, Theoretical; D010539:Permeability; D011817:Rabbits; D012306:Risk
D005452:Fluoresceins; D005839:Gentamicins; D019793:Fluorescein