Biological, microscopic and scanning electron microscopic investigations of the effects of postinor /d-norgestrel/ in rabbits.
The contraceptive effect of d-norgestrel given immediately after copulation in various quantities was investigated in rabbits. It was established that the effect is dose-dependent. A correlation was found between the amount of dose administered and the changes taking place on the surface of endometrium. It can be suggested that d-norgestrel alters the surface of the endometrium to such an extent that nidation is unable to take place; therefore, it can be used for postcoital contraception at any time.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D010064:Embryo Implantation / Q000187:drug effects; D004717:Endometrium / Q000187:drug effects*; D004848:Epithelium / Q000187:drug effects; D005260:Female; D008855:Microscopy, Electron, Scanning; D009644:Norgestrel / Q000494:pharmacology*; D011817:Rabbits
D009644:Norgestrel