[Antibiotic concentration in kidney cell fractions].
A two-compartment model of kidney cells is designed. The first compartment is the cytoplasm, the other is a large organelle fraction consisting of lysosomes and mitochondria. Drugs easily accumulated in the second compartment are considered to be harmful to the kidney. Although small molecular antibiotics move across membranes, they reach a certain equilibrium within 30 minutes. Therefore reproducible values of antibiotic concentrations in both fractions can be obtained. The two-compartment model provides a new approach to pharmacokinetic study at a subcellular level.
D000900:Anti-Bacterial Agents / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007700:Kinetics; D008247:Lysosomes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D008954:Models, Biological; D013347:Subcellular Fractions / Q000378:metabolism
D000900:Anti-Bacterial Agents