title: Genetic selection for tolerance to niclosamide and copper in Biomphalara glabrata (Mollusca: Pulmonata).
abstract: Successive generations of the PR-79 and M-line laboratory stocks of Biomphalaria glabrata were exposed in the LC90 of niclosamide or copper sulfate. Survivors from each generation produced the succeeding generation by self fertilization. The PR-79 stock showed no evidence of tolerance to either molluscicide following five generations of selection. On the other hand, M-line F5 snails demonstrated approximately two-fold higher tolerance to both molluscicides than did non-selected M-line snails.
mesh_terms: D000818:Animals; D001700:Biomphalaria / Q000187:drug effects* / Q000235:genetics; D003300:Copper / Q000494:pharmacology*; D019327:Copper Sulfate; D004361:Drug Tolerance; D009026:Mortality; D009534:Niclosamide / Q000494:pharmacology*; D012641:Selection, Genetic; D013045:Species Specificity
chemical_list: D003300:Copper; D009534:Niclosamide; D019327:Copper Sulfate