Action of tizanidine on responses of forearm flexors and extensors to torque disturbances.
The effects of tizanidine on the electromyographic responses of forearm flexors and extensors to torque disturbances were studied in normal subjects. Tizanidine had a strong depressive action on all the reflex responses, and on muscle background activity. It is concluded that the action on reflexes is not specific, but secondary to decreased spinal cord excitability.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004576:Electromyography; D005260:Female; D005542:Forearm / Q000294:innervation; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D009129:Muscle Tonus / Q000187:drug effects*; D009132:Muscles / Q000294:innervation*; D012026:Reflex, Stretch / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects
D009125:Muscle Relaxants, Central; C023754:tizanidine; D003000:Clonidine