[Kinetic characteristics of the normal enterocyte population and in carcinogenesis].
A correlation was revealed between the crypt cell proliferation changes and variations in adhesion among mature enterocytes at the extrusion zone: an increase in the proliferative activity is accompanied by a decrease in the cell adhesion, and vice versa. This dependence exists in the normal tissue and possibly serves for the epithelium protection from hypo- and hyperplasia. A distinctive feature of carcinogen treatment is the irreversible disturbance of the dependence.
D019813:1,2-Dimethylhydrazine; D000818:Animals; D002448:Cell Adhesion; D002455:Cell Division; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000473:pathology; D004127:Dimethylhydrazines; D005260:Female; D007414:Intestinal Neoplasms / Q000139:chemically induced / Q000473:pathology*; D007420:Intestine, Large / Q000166:cytology*; D007700:Kinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008938:Mitosis; D051381:Rats; D013997:Time Factors
D004127:Dimethylhydrazines; D019813:1,2-Dimethylhydrazine
Osobennosti kinetiki populiatsii énterotsitov v norme i pri kantserogeneze.