Induction of DNA synthesis in cultured rabbit uterine cells by estradiol and inhibition of the estrogen response.
Addition of 17 beta-estradiol to primary cultures of rabbit uterine cells resulted in the induction of DNA synthesis. This phenomenon is present only in cells cultured at low density. Culture medium taken from high density cultures inhibited it, suggesting that those cells produce a soluble estrogen-inhibiting factor.
D000818:Animals; D002455:Cell Division; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D004261:DNA Replication / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D011817:Rabbits; D014599:Uterus / Q000166:cytology / Q000187:drug effects / Q000502:physiology*
D004958:Estradiol; D004247:DNA