Immunoreactive trypsin level in fetoscopically-obtained cord sera of second trimester fetuses.
Immunoreactive trypsin (IRT) has been assayed in cord blood collection by fetoscopy from fetuses with estimated gestational ages of between 16-24 weeks. Eighty per cent of the specimens contained more than 5 ng/ml of IRT indicating pancreatic synthesis of trypsin by mid-term. A prenatal test for cystic fibrosis based on IRT estimation might be valid if the onset of pancreatic dysfunction associated with the disease also occurs at mid-trimester.
D003550:Cystic Fibrosis / Q000175:diagnosis*; D005260:Female; D005312:Fetal Blood / Q000201:enzymology*; D005332:Fetoscopy; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014357:Trypsin / Q000097:blood*
D014357:Trypsin