[Possible participation of a free-radical lipid intermediate in the coupling of oxidation and phosphorylation].
Data shown propose two regimes of lipid radicals and oxygen utilization realized in mitochondrial membranes. The first one--lipid peroxidation, i.e. interaction of lipid radical and oxygen is an empty step. In switching this regime to the functional one lipid peroxidation is inhibited. Setting L. -dependent coupling apparatus on phosphorylation in mitochondria takes place in the presence of ADP and Pi.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D005609:Free Radicals; D007700:Kinetics; D050356:Lipid Metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D010084:Oxidation-Reduction; D010085:Oxidative Phosphorylation; D010766:Phosphorylation; D051381:Rats
D005609:Free Radicals; D008054:Lipid Peroxides; D008315:Malondialdehyde; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate
Vozmozhnoe uchastie svobodnoradikal'nogo lipidnogo intermediata v sopriazheniia okisleniia i fosforilirovaniia.