[Changes in various biochemical indices and ultrastructure of ascites tumors after combined administration of cyclophosphamide and levorin].
The fractional composition of chromatin proteins and an electron-microscopic pattern of cell ultrastructure of the Ehrlich ascite tumours and ascite lymphoma NK/Ly were studied when suppressing their growth by a combined action of cyclophosphane and polyene antibiotic. Changes in the fractional composition of chromatin proteins were found under the effect of levorin. A sharp increase in this effect and summation of heterogeneous morphological changes provoked by each of the preparation occur under a combined application of the preparations.
D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage*; D002174:Candicidin / Q000008:administration & dosage* / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000378:metabolism* / Q000648:ultrastructure; D002843:Chromatin / Q000378:metabolism; D003520:Cyclophosphamide / Q000008:administration & dosage* / Q000494:pharmacology; D004359:Drug Therapy, Combination; D005260:Female; D006657:Histones / Q000378:metabolism; D008223:Lymphoma / Q000188:drug therapy / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D009363:Neoplasm Proteins / Q000378:metabolism
D000935:Antifungal Agents; D002843:Chromatin; D006657:Histones; D009363:Neoplasm Proteins; D002174:Candicidin; D003520:Cyclophosphamide
Izmenenie nekotorykh biokhimicheskikh pokazateleĭ i ul'trastruktury astsitnykh opukholeĭ pri sochetannom vozdeĭstvii tsiklofosfana i levorina.