[Bioelectric activity and metabolism of individual brain structures at different times after administration of synthetic tetrapeptidamide].
Complex study of the opioid tetrapeptide amid (TPA) effect on metabolism and neurophysiological processes of different cortical areas, caudate nucleus n. accumbens allowed to detect prolonged (several days) specific action on these structures. The influence was manifested in certain changes of transmitter metabolism, background bioelectric activity, as well as in changes of EEG reactions to adequate afferent signals. The duration of the detected changes significantly exceeded the duration of anti-pain TPA effect.
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects*; D002682:Chinchilla; D003201:Computers; D004569:Electroencephalography; D005074:Evoked Potentials, Visual; D008995:Monoamine Oxidase / Q000378:metabolism; D009714:Nucleus Accumbens / Q000187:drug effects*; D009842:Oligopeptides / Q000494:pharmacology*; D012686:Septal Nuclei / Q000187:drug effects*
D009842:Oligopeptides; C037379:tyrosyl alanyl-glycyl-phenylalaninamide; D008995:Monoamine Oxidase; D000110:Acetylcholinesterase
Bioélektricheskaia aktivnost' i metabolizm otdel'nykh struktur mozga v razlichnye sroki posle vvedeniia sinteticheskogo tetrapeptidamida.