Depression of lymphocyte traffic in sheep by induced systemic arterial hypotension and by acute arterial occlusion.
Shock and arterial insufficiency have been observed to be associated with increased levels of sepsis and mortality. As the vast majority of small recirculating lymphocytes reach lymph nodes in arterial blood, the haemodynamic components of lymph node function would appear to be of importance. Lymphocyte traffic in sheep, as mirrored by the output of lymphocytes into the efferent lymph of popliteal lymph nodes, obtained by chronic cannulation of efferent lymphatics, was found to be sharply depressed both by intravenous nitroprusside infusion induced systemic arterial hypotension and by acute femoral arterial ligation on the side of the study node. In the nitroprusside infusion induced arterial hypotension studies, the depressions in lymphocyte traffic were closely related to the depressions in systemic arterial blood pressure. Excellent colateral circulation and compensatory physiological mechanisms in the sheep limited the duration of these depressions in lymphocyte traffic.
D000818:Animals; D001157:Arterial Occlusive Diseases / Q000473:pathology*; D001794:Blood Pressure; D002465:Cell Movement; D005263:Femoral Artery; D007022:Hypotension / Q000139:chemically induced / Q000473:pathology*; D008196:Lymph / Q000166:cytology; D008198:Lymph Nodes / Q000473:pathology; D008214:Lymphocytes / Q000502:physiology*; D009599:Nitroprusside; D012756:Sheep
D009599:Nitroprusside