Determination of isosorbide 5-mononitrate in human plasma by capillary column gas chromatography.
An electron-capture gas chromatographic method for the determination of isosorbide 5-mononitrate in human plasma using a capillary column is described. Isosorbide 5-mononitrate and the internal standard (isosorbide dinitrate) are extracted from the alkalinized plasma with ether. The lower limit of detection for isosorbide 5-mononitrate is 1 ng/mL of plasma.
D002849:Chromatography, Gas / Q000379:methods; D006801:Humans; D007548:Isosorbide Dinitrate / Q000031:analogs & derivatives* / Q000097:blood
D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate