title: The effects of xylitol on gastric emptying and secretion of gastric inhibitory polypeptide in the rat.
abstract: The effects of xylitol on the rate of gastric emptying and plasma gastric inhibitory polypeptide secretion in the rat were studied to relate xylitol adaptation to these phenomena. Male Sprague-Dawley rats, weighing about 250-270 g, were either gradually adapted to 20% xylitol diets or given a basal diet. The animals were, after a 24-hour fast, given a 1.2 g/kg body weight dose of xylitol or glucose either alone or with a 99mTc-tin colloid marker to study gastric emptying by using a gamma camera. Blood was taken from the tail vein, and plasma was analyzed for immunoreactive gastric inhibitory polypeptide by using a double-antibody radioimmunoassay. Xylitol adaptation did not appear to have any effect on the secretion of gastric inhibitory polypeptide. However, adaptation of rats to 20% dietary xylitol appeared to change the rate of gastric emptying by decreasing it. Therefore, it was concluded that gastric emptying plays a role in the adaptation to high xylitol doses while gastric inhibitory polypeptide appears not to be involved.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D005746:Gastric Emptying / Q000187:drug effects*; D005749:Gastric Inhibitory Polypeptide / Q000097:blood / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D014993:Xylitol / Q000494:pharmacology*
chemical_list: D005749:Gastric Inhibitory Polypeptide; D005947:Glucose; D014993:Xylitol