title: Effects of low pH on synthesis and release of catecholamines in the cat carotid body in vitro.
abstract: The rates of dopamine and noradrenaline synthesis in the cat carotid body (c.b.) are 5.9 +/- 0.58 pmol/c.b./2 h and 0.3 +/- 0.02 pmol/c.b./2 h, respectively. The synthesis is doubled when the organs are incubated at pH 7. Similarly, low pH induces a release of dopamine from the c.b. which is proportional to increased activity in the carotid sinus nerve.
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000096:biosynthesis / Q000378:metabolism; D000818:Animals; D002344:Carotid Body / Q000378:metabolism*; D002415:Cats; D004298:Dopamine / Q000096:biosynthesis* / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009638:Norepinephrine / Q000096:biosynthesis* / Q000378:metabolism; D014443:Tyrosine / Q000096:biosynthesis
chemical_list: D015102:3,4-Dihydroxyphenylacetic Acid; D014443:Tyrosine; D004298:Dopamine; D009638:Norepinephrine