Amplification of the c-myc oncogene in human stomach cancers.
Amplified c-myc oncogene was found in the DNAs of 2 of 11 human stomach cancers transplanted into nude mice; the amplification was 8- to 10-fold in one tumor and 13- to 15-fold in the other. Both tumors in which the c-myc oncogene was amplified were poorly differentiated adenocarcinomas, but there was no clear-cut correlation between the histological types or growth rates of the tumors and amplification of the c-myc oncogene. No amplification of the c-myc gene was detected in DNAs from 4 cultured stomach cancer cell lines, 19 primary stomach cancers or 11 metastases to lymph nodes from human stomach cancers.
D000230:Adenocarcinoma / Q000235:genetics; D000818:Animals; D004273:DNA, Neoplasm / Q000032:analysis; D005784:Gene Amplification; D006801:Humans; D008207:Lymphatic Metastasis; D051379:Mice; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D013274:Stomach Neoplasms / Q000235:genetics*
D004273:DNA, Neoplasm