title: Clinical pharmacology. Clinical uses of pharmacokinetic principles in prescribing cardiac drugs.
abstract: Drug disposition is the sum of the processes of absorption, distribution, metabolism, and elimination. Knowledge of the factors affecting the rates and extent of these processes facilitates the design of dosing regimens, including calculation of loading dose, maintenance dose, and infusion rate. This information is especially useful in treating patients with low cardiac output, or with intrinsic hepatic or renal disease.
mesh_terms: D001711:Biotransformation; D002317:Cardiovascular Agents / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics
chemical_list: D002317:Cardiovascular Agents