Urinary excretion of 3-hydroxy-benzo[a]pyrene after percutaneous penetration and oral absorption of benzo[a]pyrene in rats.
A method for the monitoring of exposure to benzo[a]pyrene was applied to rat urine samples. Benzo[a]pyrene was administered percutaneously and orally with repeated doses of 10, 20 and 50 mumol/kg body wt. At low dose levels, the urinary excretion of 3-OH-benzo[a]pyrene was higher after percutaneous treatment than after oral administration. The excretion of 4 benzo[a]pyrene metabolites, including 3-OH-benzo[a]pyrene, is faster after oral administration. The percutaneous absorption of small doses of benzo[a]pyrene appears to be greater than the oral absorption.
D000818:Animals; D001564:Benzo(a)pyrene / Q000008:administration & dosage / Q000378:metabolism*; D001580:Benzopyrenes / Q000652:urine*; D002851:Chromatography, High Pressure Liquid; D007408:Intestinal Absorption; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012869:Skin Absorption; D013997:Time Factors
D001580:Benzopyrenes; D001564:Benzo(a)pyrene; C021338:3-hydroxybenzo(a)pyrene