Effect of polyprenoic acid (E5166) on a human neuroblastoma cell line in culture.
The antineoplastic effects of a novel retinoid derivative E5166 on cultured human neuroblastoma, GOTO cells, were investigated. E5166, as well as retinoic acid and retinol, suppressed the proliferation of GOTO cells and the synthesis of DNA, RNA and protein; the inhibitory potency of E5166 was not stronger than that of the natural vitamin A derivatives. E5166 also inhibited amino acid transport, but was found to stimulate sugar transport in the neuroblastoma cells.
D000596:Amino Acids / Q000378:metabolism; D001693:Biological Transport, Active / Q000187:drug effects; D050260:Carbohydrate Metabolism; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004224:Diterpenes / Q000494:pharmacology*; D006801:Humans; D009363:Neoplasm Proteins / Q000096:biosynthesis; D009447:Neuroblastoma / Q000188:drug therapy* / Q000378:metabolism; D012334:RNA, Neoplasm / Q000096:biosynthesis; D014212:Tretinoin / Q000031:analogs & derivatives*
D000596:Amino Acids; D004273:DNA, Neoplasm; D004224:Diterpenes; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm; D014212:Tretinoin; C034534:3,7,11,15-tetramethyl-2,4,6,10,14-hexadecapentaenoic acid