Pentoxifylline reverses age-related deficits in spatial memory.
Pentoxifylline, a phosphodiesterase inhibitor, produces a marked reversal of an age-dependent spatial memory deficit in Fischer 344 strain male rats. Performance of 26-month-old animals treated chronically with pentoxifylline approached that of 3-month-old controls. The effect was not dependent upon concurrent administration of the acetylcholine precursor choline chloride. It is concluded that the pentoxifylline-induced reversal of the age-dependent memory decline is not dependent on any presumed facilitation of acetylation and utilization of exogenously supplied transmitter substrate.
D000375:Aging / Q000187:drug effects*; D000818:Animals; D002794:Choline / Q000494:pharmacology; D003463:Cues; D004193:Discrimination Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D009949:Orientation / Q000187:drug effects*; D010431:Pentoxifylline / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D013028:Space Perception / Q000187:drug effects*; D013805:Theobromine / Q000031:analogs & derivatives*
D002794:Choline; D013805:Theobromine; D010431:Pentoxifylline