The pharmacokinetics of fenbendazole and oxfendazole in cattle.
The pharmacokinetics of fenbendazole and oxfendazole in cattle are described. The pharmacokinetics of oxfendazole were not significantly different when administered orally and by intra-ruminal injection. At a dose rate of 4.5 mg/kg, administered orally, fenbendazole gave rise to mean peak concentrations in plasma of fenbendazole and oxfendazole of 0.11 and 0.13 microgram/ml respectively. Oral administration of oxfendazole, at 4.5 mg/kg body weight, gave rise to plasma peak concentrations of fenbendazole and oxfendazole of 0.10 and 0.20 microgram/ml respectively. Following intra-ruminal administration of oxfendazole, the peak concentrations were 0.11 and 0.18 microgram/ml respectively.
D000818:Animals; D001562:Benzimidazoles / Q000008:administration & dosage / Q000378:metabolism*; D002417:Cattle / Q000378:metabolism*; D002418:Cattle Diseases / Q000188:drug therapy; D005260:Female; D005273:Fenbendazole / Q000008:administration & dosage / Q000378:metabolism*; D007700:Kinetics; D008297:Male
D001562:Benzimidazoles; D005273:Fenbendazole; C011030:oxfendazole