Autoimmunity and increased c-myb transcription.
A single recessive gene, lpr, induces an autoimmune-lymphoproliferative syndrome in several strains of mice. The lymphoid organs of lpr/lpr mice contained cells with increased amounts of myb RNA, which codes for a protein found in the nucleus. A similar human lymphoproliferative disorder also had an increase in c-myb expression. Mouse T cells induced by mitogens to proliferate did not express large amounts of myb RNA, indicating that marked myb expression is not a general feature of lymphocyte activation and proliferation.
D000818:Animals; D001323:Autoantibodies / Q000235:genetics*; D001327:Autoimmune Diseases / Q000235:genetics*; D005260:Female; D005808:Genes, Recessive; D008214:Lymphocytes / Q000276:immunology; D008232:Lymphoproliferative Disorders / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D013045:Species Specificity; D013154:Spleen / Q000276:immunology; D014158:Transcription, Genetic
D001323:Autoantibodies