Sodium lauryl sulfate irritant patch tests. III. Evaporation of aqueous vehicle influences inflammatory response.
Patch tests with aqueous solutions of the irritating detergent sodium lauryl sulfate (SLS) elicit varying degrees of inflammation from subject to subject and from site to site. For an investigation of the causes of this variability, two patch tests with 10% aqueous solutions of SLS were applied to adjacent areas of ventral forearm skin of eighteen volunteers. In one test the water vehicle was allowed to evaporate from the patch test unit before the patches were applied. After 22 hours the patch tests were removed, and 2 hours later the degree of inflammation was graded. Less inflammation was present at the site of the dry patch test in fifteen of eighteen subjects, and the score of inflammation between each pair was significantly less at the dry patch test site (p less than 0.001). These studies show that evaporation of water from aqueous solutions can influence the irritating potential of SLS on human skin.
D000328:Adult; D002626:Chemistry, Pharmaceutical; D003877:Dermatitis, Contact / Q000175:diagnosis*; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced*; D004890:Erythema / Q000139:chemically induced*; D005260:Female; D005542:Forearm / Q000187:drug effects; D006801:Humans; D007509:Irritants; D008297:Male; D010328:Patch Tests / Q000379:methods; D014677:Pharmaceutical Vehicles; D012867:Skin / Q000187:drug effects; D012967:Sodium Dodecyl Sulfate / Q000008:administration & dosage / Q000633:toxicity*; D013997:Time Factors; D014835:Volatilization; D014867:Water
D007509:Irritants; D014677:Pharmaceutical Vehicles; D014867:Water; D012967:Sodium Dodecyl Sulfate