3'-Deoxyinosine as an anti-leishmanial agent: the metabolism and cytotoxic effects of 3'-deoxyinosine in Leishmania tropica promastigotes.
3'-Deoxyinosine is a potent inhibitor for growth of the promastigote form of Leishmania tropica. In culture, EC50 value is 4.43 X 10(-7) M for the promastigote. On the other hand, it is less toxic towards mouse mammary tumor FM3A cells: EC50 value is 1.25 X 10(-4) M. 3'-Deoxyinosine is metabolized by Leishmania promastigote to give 3'-deoxyinosine-5'-monophosphate and 3'-deoxyadenosine(cordycepin)-5'-mono-, di-, and triphosphates. This metabolic conversion provides a mechanism for the parasite-selective toxicity of 3'-deoxyinosine: Leishmania can aminate the 6-position of 3'-deoxyinosine residue, thereby converting a less toxic nucleoside into the cordycepin nucleotides that are known to be highly toxic to cells.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D007288:Inosine / Q000031:analogs & derivatives* / Q000378:metabolism / Q000494:pharmacology; D007891:Leishmania / Q000187:drug effects*; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism; D051379:Mice
D007288:Inosine; C012271:deoxyinosine