title: Evidence for sphincter dysfunction in patients with gallstone associated pancreatitis: effect of ceruletide in patients undergoing cholecystectomy for gallbladder disease and gallstone associated pancreatitis.
abstract: The functional activity of the sphincter of Oddi complex has been examined by ceruletide manometry in patients undergoing cholecystectomy with a normal peroperative cholangiogram. In Group I (n = 14), which included patients with previous acute cholecystitis/biliary colic, the sphincter activity appeared to be normal and responded to intravenous ceruletide by a marked relaxation with a significant fall in both the infusion and postinfusion pressures. In patients undergoing cholecystectomy for gallstone-associated pancreatitis (n = 8), the sphincter exhibited manometric features of hypotonia with low infusion and postinfusion pressures which were not significantly altered by intravenous ceruletide.
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D014670:Ampulla of Vater / Q000503:physiopathology*; D002108:Ceruletide / Q000494:pharmacology*; D002763:Cholecystectomy; D002764:Cholecystitis / Q000503:physiopathology; D002769:Cholelithiasis / Q000503:physiopathology* / Q000601:surgery; D003085:Colic / Q000503:physiopathology; D003135:Common Bile Duct / Q000503:physiopathology; D006801:Humans; D008365:Manometry; D008875:Middle Aged; D010195:Pancreatitis / Q000503:physiopathology*; D009803:Sphincter of Oddi / Q000187:drug effects / Q000503:physiopathology*
chemical_list: D002108:Ceruletide