Experience with barbiturate therapy for cerebral protection during carotid endarterectomy.
Carotid endarterectomy was performed 28 times in 27 patients. All but one patient had symptomatic carotid artery disease, 59% had bilateral disease and 59% had associated intracranial disease. Barbiturate therapy was used as a means of cerebral protection during carotid artery cross-clamping. Neurological deficit occurred in two patients, being permanent in one patient (3.5%); both patients had bilateral carotid and intracranial disease and both had carotid stump pressures greater than 55 mmHg. No morbidity could be attributed to barbiturate usage.
D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage; D001794:Blood Pressure; D001927:Brain Diseases / Q000601:surgery; D002339:Carotid Arteries / Q000601:surgery*; D002340:Carotid Artery Diseases / Q000601:surgery; D002561:Cerebrovascular Disorders / Q000517:prevention & control*; D003250:Constriction; D004691:Endarterectomy; D005260:Female; D006801:Humans; D007431:Intraoperative Complications / Q000517:prevention & control; D002546:Ischemic Attack, Transient / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012306:Risk; D013874:Thiopental / Q000627:therapeutic use*
D000925:Anticoagulants; D013874:Thiopental