Hyperpolarizing action of baclofen on neurons in the rat substantia nigra slice.
GABA, muscimol and L-baclofen inhibited zona compacta neurons in the rat substantia nigra slice, D-baclofen was inactive, L-baclofen produced a potent hyperpolarization of the membrane potential. The actions of muscimol but not GABA and L-baclofen were reversed by bicuculline. The actions of muscimol and baclofen are likely to be mediated by interactions with two different receptors.
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D001640:Bicuculline / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D009118:Muscimol / Q000494:pharmacology; D051381:Rats; D013378:Substantia Nigra / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D001418:Baclofen; D004298:Dopamine; D001640:Bicuculline