title: Transdermal therapeutic system scopolamine (TTSS), dimenhydrinate, and placebo--a comparative study at sea.
abstract: The efficacy of transdermally administered scopolamine was compared with the efficacy of oral dimenhydrinate and placebo therapy in the prevention of motion sickness at sea. Medication was administered on a controlled double blind basis to 140 subjects. A placebo effect reduced the motion sickness incidence (MSI) from 57.69% in the control group to 43.47%. Administration of dimenhydrinate reduced the MSI to 22.22% and the use of Transdermal Therapeutic System Scopolamine (TTSS) further reduced the MSI to 16.66%. TTSS afforded 61.67% protection against motion sickness at sea, compared to 48.88% protection with dimenhydrinate.
mesh_terms: D000287:Administration, Topical; D000328:Adult; D004111:Dimenhydrinate / Q000008:administration & dosage* / Q000627:therapeutic use; D004311:Double-Blind Method; D006801:Humans; D008297:Male; D009041:Motion Sickness / Q000453:epidemiology / Q000517:prevention & control*; D012601:Scopolamine / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D012601:Scopolamine; D004111:Dimenhydrinate