Penicillin-induced lysis of Streptococcus mutans.
Treatment of Streptococcus mutans GS-5 cells with concentrations of penicillin G within a relatively narrow range resulted in substantial lysis. This penicillin-induced lysis was dependent upon cell density and pH of the lysis medium. Other oral streptococci (Streptococcus sobrinus, Streptococcus rattus, and Streptococcus cricetus) also demonstrated substantial levels of penicillin-induced lysis under appropriate conditions. Lesser degrees of lysis were seen in a related organism, Streptococcus ferus.
D004305:Dose-Response Relationship, Drug; D006863:Hydrogen-Ion Concentration; D010400:Penicillin G / Q000494:pharmacology*; D013295:Streptococcus mutans / Q000187:drug effects* / Q000254:growth & development
D010400:Penicillin G