Effect of magnesium ion upon the calcitonin content of rat thyroid.
Thyroid calcitonin level was assayed in male rats after administration of magnesium gluconolactate. The resulting acute hypermagnesemia caused a significant decrease in calcitonin. However, calcemia showed unimportant changes, which suggests that the inhibitory action of magnesium is exerted directly on calcitonin secretion and is not affected by the calcium ion.
D000818:Animals; D002116:Calcitonin / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D007773:Lactates / Q000494:pharmacology*; D019344:Lactic Acid; D008274:Magnesium / Q000097:blood; D008297:Male; D051381:Rats; D013961:Thyroid Gland / Q000378:metabolism*
D007773:Lactates; D019344:Lactic Acid; D002116:Calcitonin; D008274:Magnesium; D002118:Calcium