Functional tolerance to alprazolam-induced neurologic deficits in mice.
Tolerance to alprazolam-induced neurologic deficits was assessed in mice by a rotarod test. Tolerance was found following a second administration of 2 mg/kg alprazolam 24 h after the first dose and it decayed gradually over a period of several weeks. Brain and plasma concentrations of alprazolam indicated that this tolerance was functional.
D000525:Alprazolam; D000818:Animals; D001569:Benzodiazepines / Q000378:metabolism / Q000633:toxicity*; D001921:Brain / Q000187:drug effects; D004361:Drug Tolerance; D006993:Hypnotics and Sedatives / Q000633:toxicity*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009420:Nervous System / Q000187:drug effects / Q000503:physiopathology*
D006993:Hypnotics and Sedatives; D001569:Benzodiazepines; D000525:Alprazolam