title: [Mechanisms of action of high and superhigh doses of gamma-quanta and neutrons on the central nervous system].
abstract: Wistar rats were exposed to gamma-quanta (60Co, 100-400 Gy) and neutrons (100-200 Gy). The C. N. S. syndrome was shown to develop the neuron lesions being relatively minor. With a reference to this index, the RBE of neutrons was 1.75. The permeability of blood vessels of the brain was decreased during the development of the C. N. S.-syndrome. Disturbances in the functional state of neurons and interneuron reactions, including the changes in the mediator metabolism (these changes were manifested by the increased GABA content of the cerebellum), play, in all appearance, an important role in the impairment of the brain function under the effect of high doses of neutrons and gamma-quanta.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects*; D002531:Cerebellum / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D005720:Gamma Rays; D008297:Male; D009502:Neutrons; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D012062:Relative Biological Effectiveness; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D005680:gamma-Aminobutyric Acid
vernacular_title: K issledovaniiu mekhanizmov deĭstviia vysokikh i sverkhvysokikh doz gamma-kvantov i neĭtronov na tsentral'nuiu nervnuiu sistemu.