title: Coronary artery spasm--1984.
abstract: Coronary artery spasm was virtually unknown not long ago, but the intense, ongoing interest it has generated in the past decade has produced a number of specific diagnostic techniques and therapeutic approaches, as well as considerable insight into mechanisms of coronary vascular tone and various coronary syndromes. There is growing evidence that coronary artery spasm is involved in unstable angina, stable angina, myocardial infarction, and sudden death. It is by no means a benign process and is associated with significant morbidity or mortality if misdiagnosed or untreated. It seems clear that what started as a mere clinical curiosity involving a minority of patients with the so-called Prinzmetal's variant angina is snowballing into a major arena for research, diagnosis, and treatment in the field of ischemic coronary artery disease.
mesh_terms: D001145:Arrhythmias, Cardiac / Q000150:complications; D002118:Calcium / Q000378:metabolism; D002121:Calcium Channel Blockers / Q000627:therapeutic use; D003329:Coronary Vasospasm / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000378:metabolism; D003645:Death, Sudden / Q000150:complications; D004562:Electrocardiography; D006801:Humans; D011453:Prostaglandins / Q000378:metabolism; D013928:Thromboxane A2 / Q000378:metabolism
chemical_list: D002121:Calcium Channel Blockers; D011453:Prostaglandins; D013928:Thromboxane A2; D002118:Calcium