UV irradiation and cutaneous vitamin A: an experimental study in rabbit and human skin.
The effect of UV irradiation on the concentration of cutaneous retinoids (retinol and 3-dehydroretinol) in rabbit skin in vivo and in human skin in vitro was investigated. Irradiation with 4 different narrow-wavelength bands produced dose-dependent reductions of retinol in epidermis and dermis. The maximal effect was obtained at 334 nm, a wavelength which coincides with the absorption maximum for retinol in organic solutions. 3-Dehydroretinol was not reduced to the same extent as was retinol. In human skin the photodecomposition of retinol was most extensive in epidermis and progressively less so in dermis, presumably reflecting the extent to which 334 nm radiation penetrates the tissue. The regeneration of cutaneous retinol took over a week in the rabbit. The nutritional and biologic implications of the UV-induced reduction of cutaneous retinol remain to be established.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004817:Epidermis / Q000032:analysis / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D066298:In Vitro Techniques; D011817:Rabbits; D012867:Skin / Q000032:analysis / Q000378:metabolism / Q000528:radiation effects*; D014466:Ultraviolet Rays; D014801:Vitamin A / Q000031:analogs & derivatives / Q000032:analysis*
C024366:vitamin A2; D014801:Vitamin A