3-Aminobenzamide-induced sister chromatid exchanges are dependent on incorporated bromodeoxyuridine in DNA.
Data are presented establishing a direct correlation between 3-aminobenzamide-induced sister chromatid exchange (SCE) frequency and the level of bromodeoxyuridine (BrdU) incorporated into DNA. In addition, it is shown that most of the SCEs are induced in the second cell cycle, in which BrdU-containing DNA is used as the template for replication.
D000818:Animals; D001549:Benzamides / Q000494:pharmacology*; D001973:Bromodeoxyuridine; D002453:Cell Cycle; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000235:genetics* / Q000302:isolation & purification; D005260:Female; D010053:Ovary; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D001549:Benzamides; C025160:3-aminobenzamide; D004247:DNA; D001973:Bromodeoxyuridine