[Use of sodium nucleinate and its combinations with bacterial polysaccharides for preventing the nephrotoxic action of aminoglycoside antibiotics].
Possible prevention of the nephrotoxic effect of different doses of aminoglycoside antibiotics, such as monomycin, kanamycin and gentamicin was studied experimentally on chinchilla rabbits. Substances increasing the cell resistance (sodium nucleinate, prodigiosan and pyrogenal alone and sodium nucleinate combinations with the bacterial polysaccharides) were used. It was shown that sodium nucleinate prevented nephrotoxicity of the aminoglycosides in the doses 2.5 times higher than the therapeutic ones. The combined use of sodium nucleinate with pyrogenal or prodigiosan was most effective. It prevented the nephrotoxic effect of the antibiotics in the doses 5 times higher than the therapeutic ones.
D000617:Aminoglycosides / Q000037:antagonists & inhibitors / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D007668:Kidney / Q000187:drug effects*; D008070:Lipopolysaccharides / Q000627:therapeutic use; D009696:Nucleic Acids / Q000627:therapeutic use*; D011135:Polysaccharides, Bacterial / Q000627:therapeutic use*; D011354:Prodigiozan / Q000627:therapeutic use; D012331:RNA, Fungal / Q000627:therapeutic use*; D011817:Rabbits; D013997:Time Factors
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D008070:Lipopolysaccharides; D009696:Nucleic Acids; D011135:Polysaccharides, Bacterial; D012331:RNA, Fungal; C009136:pyrogenal; C013683:sodium nucleinate; D011354:Prodigiozan
Primenenie nukelinata natriia i ego sochetaniĭ s bakterial'nymi polisakharidami dlia predotvrashcheniia nefrotoksicheskogo deĭstviia antibiotikov-aminoglikozidov.