[The effect of antitumor vaccine on the recurrence of solid tumors in mice subjected to surgery].
The frequency of tumour recurrences in A/Sn mice with operated Ehrlich carcinomas and treated with lyophylized antitumour vaccine and trypan blue or both of them was investigated. The tumours in vaccinated mice relapsed by the 47th day after the operation in 10% of cases, in 50% of control animals, the injection of trypan blue increased the tumour recurrences by 20%. The antitumour effect of vaccination is associated with the enhancement of the activity of the cellular and humoral immune systems. The trypan blue inhibition of the macrophage function suppresses the antitumor activity of the immunity cellular components.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology / Q000601:surgery / Q000628:therapy*; D003131:Combined Modality Therapy; D007167:Immunotherapy; D008264:Macrophages / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D014343:Trypan Blue / Q000494:pharmacology; D014612:Vaccines / Q000008:administration & dosage*
D014612:Vaccines; D014343:Trypan Blue
Vliianie protivoopukholevoĭ vaktsiny na retsidivirovanie solidnykh novoobrazovaniĭ u prooperirovannykh mysheĭ.