Hemophilia in dogs, with special reference to hemophilia A among German shepherd dogs in Denmark. II: Clinical study, therapy and prophylaxis.
Clinical data, pedigrees, screening tests (APTT, PT and TT) and specific tests (VIII:C, VIIIC:Ag, VIIIR:Ag and IX:C) were used to diagnose hemophilia A (classical hemophilia) in two colonies of German Shepherd dogs in Denmark. The affected individuals in both colonies were males, and they descended from a common, hemophilic ancestor. All observations were in accordance with X-linked, recessive inheritance. Therapeutic and prophylactic measures are discussed.
D000818:Animals; D001803:Blood Transfusion; D004283:Dog Diseases / Q000097:blood*; D004285:Dogs; D005260:Female; D006467:Hemophilia A / Q000517:prevention & control / Q000628:therapy / Q000662:veterinary*; D008297:Male; D010375:Pedigree