Glucose-6-phosphate dehydrogenase revisited.
Hemolytic diseases associated with drugs have been recognized since antiquity. Many of these anemias have been associated with oxidizing agents and deficiencies in the intraerythrocytic enzyme glucose-6-phosphate dehydrogenase. This paper outlines the discovery, prevalence, and variants of this enzyme. Methods of diagnosis of associated anemias are offered.
D000634:Aminoquinolines / Q000009:adverse effects; D000743:Anemia, Hemolytic / Q000139:chemically induced / Q000175:diagnosis / Q000201:enzymology* / Q000453:epidemiology / Q000503:physiopathology; D002237:Carbohydrate Dehydrogenases / Q000172:deficiency*; D005236:Favism / Q000201:enzymology; D005260:Female; D005948:Glucose Dehydrogenases / Q000172:deficiency* / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D044469:Racial Groups
D000634:Aminoquinolines; D006454:Hemoglobins; C004331:pamaquine; D002237:Carbohydrate Dehydrogenases; D005948:Glucose Dehydrogenases