Inhibition of replicative DNA synthesis in nuclei of Strongylocentrotus intermedium urchin embryo by 2',3'-dideoxy-3'-aminonucleoside 5'-triphosphates.
2',3'-Dideoxy-3'-aminonucleoside 5'-triphosphates have been shown to be inhibitors of replicative DNA synthesis in isolated nuclei of sea urchin embryo. These compounds inhibit the Okazaki fragment synthesis. The effect of 2',3'-dideoxy-3'-aminothymidine 5'-triphosphate and arabinothymidine 5'-triphosphate is reversible when adding the corresponding substrate for DNA synthesis, 2'-deoxythymidine 5'-triphosphate.
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism*; D004247:DNA / Q000096:biosynthesis; D004261:DNA Replication / Q000187:drug effects*; D003854:Deoxyribonucleotides / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D012617:Sea Urchins / Q000196:embryology
D003854:Deoxyribonucleotides; C022262:Okazaki fragments; D004247:DNA