title: [Recurring thrombosis of the subclavian vein during estrogen therapy of prostatic cancer].
abstract: A cardiac pacemaker had been implanted in a patient with carcinoma of the prostate because of a sick sinus node. Thrombosis of the left subclavian vein occurred four weeks later. After complete recanalisation following thrombolytic treatment a recurrence of the thrombosis occurred during high-dosage intravenous oestrogen treatment. Continuous increase of prothrombin time was observed during oestrogen administration while the oral anticoagulation had remained unaltered. This indicated increase of synthesis of vitamin-K-dependent clotting factors by the oestrogens. This case demonstrates that in patients with implanted material and oral long-term anticoagulation the indication for oestrogen treatment must be extremely accurately. In every case very close surveillance of coagulation is necessary.
mesh_terms: D001780:Blood Coagulation Tests; D004967:Estrogens / Q000627:therapeutic use*; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D012008:Recurrence; D013300:Streptokinase / Q000627:therapeutic use; D013350:Subclavian Vein; D013924:Thrombophlebitis / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D004967:Estrogens; D006493:Heparin; D013300:Streptokinase
vernacular_title: Rezidivierende Thrombose der Vena subclavia während Ostrogentherapie eines Prostatakarzinoms.