[Effect of local moderate hyperthermia in combination with chemotherapy by N-nitroso-1,3-bis-(2-chloroethyl)urea (BCNU) on the descending colon of the rat with transplanted Yoshida sarcoma. 2. Monochemotherapy in combination with subsequent hyperthermia at various time intervals].
There are numerous reports on in vitro and in vivo investigations of hyperthermia for cytostasis of malignant tumors. Combination of chemotherapy and hyperthermia is to potentiate the therapeutic effect. The time interval between the two types of therapy was the main subject of the present investigation. Local hyperthermia (43 degrees C, 60 min) following BCNU chemotherapy at intervals of 0, 3, 6, 9, 12, and 24 h, respectively, was studied in a colonic Yoshida sarcoma model in Sprague-Dawley rats. No significant increase in the curing rate resulted from hyperthermic treatment. The results suggest that the highly anticipated hyperthermic peritoneal lavages should be investigated in controlled animal experiments prior to clinical use.
D000818:Animals; D002330:Carmustine / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000628:therapy*; D003131:Combined Modality Therapy; D006979:Hyperthermia, Induced / Q000379:methods*; D008297:Male; D009368:Neoplasm Transplantation; D011379:Prognosis; D051381:Rats; D011919:Rats, Inbred Strains; D012517:Sarcoma, Yoshida / Q000628:therapy*; D013997:Time Factors
D002330:Carmustine
Wirkung der lokalen moderaten Hyperthermie in Kombination mit einer Chemotherapie durch N-Nitroso-1,3-bis-(2-chloroethyl)-harnstoff (BCNU) auf das in das Colon descendens der Ratte transplantierte Yoshida-Sarkom. 2. Mitteilung: Monochemotherapie in Kombination mit nachfolgender Hyperthermie in unterschiedlichen Zeitintervallen.