title: Excess of cancer deaths in close relatives of patients with bilateral retinoblastoma.
abstract: Cancer deaths among close relatives of 19 patients with bilateral retinoblastoma were reviewed. Altogether 18 deaths of nonocular cancer were found in 5 families. These constitute 5% of the entire material of 365 relatives. The main types of cancer were stomach (6 cases), bronchial (3 cases), urinary bladder carcinoma (2 cases), as well as 2 cases of reticulosarcoma and 1 of leukemia. The retinoblastoma gene may also be associated with higher incidence of cancer in families of retinoblastoma patients.
mesh_terms: D005134:Eye Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000235:genetics* / Q000401:mortality; D009378:Neoplasms, Multiple Primary / Q000235:genetics*; D009857:Oncogenes; D010375:Pedigree; D012175:Retinoblastoma / Q000235:genetics*