Influence of nicotine on N-nitrosomethylurea-induced mammary tumors in rats.
The possible influence of nicotine tartrate on carcinogenesis induced by N-Nitrosomethylurea (NMU) in the mammary gland of female Sprague-Dawley rats was investigated. NMU given i.v. at a single dose of 50 mg/kg on day 52 induced a 100% yield of mammary tumors. Additional subcutaneous administration of individual doses of 0.5 mg/kg of nicotine on days 46-52 and 55-145 (twice a week), respectively, did not modify the NMU-induced carcinogenesis. No further tumors developed in untreated and nicotine-treated animals, thus giving no evidence that nicotine can influence chemical-induced tumors.
D000236:Adenoma / Q000139:chemically induced / Q000473:pathology*; D000818:Animals; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology*; D008770:Methylnitrosourea; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D008770:Methylnitrosourea; D009538:Nicotine