[Antidiuretic hormone content in the neurohypophysis of adult white rats after hydrocortisone administration in the early postnatal period].
The age-related time-course of changes in arginine-vasopressin (AVP) content in the pituitary gland was studied in adult intact Wistar rats. In 60-day-old rats, the hormone content was measured before and after 24 h of water deprivation. In adult rats treated with a single injection of hydrocortisone at different times after birth, the content of AVP remained high in rats injected with hydrocortisone on day 2 or day 5 after birth, exceeding significantly the content of AVP in intact rats. The animals injected with hydrocortisone on day 9 or 15 manifested a more noticeable reduction in the hormone content, as was the case in intact rats. It is suggested that the first five days after birth is a critical period in the formation of the central regulation of AVP secretion with high sensitivity to short-term changes in corticosteroid balance.
D000375:Aging / Q000187:drug effects*; D000818:Animals; D000831:Animals, Newborn; D002853:Chromatography, Liquid; D006854:Hydrocortisone / Q000494:pharmacology*; D010904:Pituitary Gland, Posterior / Q000032:analysis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D014667:Vasopressins / Q000032:analysis*; D014868:Water Deprivation / Q000187:drug effects / Q000502:physiology
D014667:Vasopressins; D006854:Hydrocortisone
Soderzhanie antidiureticheskogo gormona v neĭrogipofize u vzroslykh belykh krys posle vvedeniia gidrokortizona v rannem postnatal'nom periode.