Coronary artery spasm and cardiac arrest in carcinoid heart disease.
Previously reported cardiac manifestations of carcinoid disease include right-sided valvular dysfunction and vasomotor disturbances. This report describes a 62-year-old white man who had electrocardiographically documented widespread elevation of the S-T segment, arrhythmias, and cardiac arrest after exercise. Noninvasive and laboratory studies confirmed the diagnosis of malignant carcinoid disease with tricuspid valve involvement. Coronary angiography revealed mild atherosclerosis. Thus, coronary artery spasm is a previously unrecognized manifestation of carcinoid heart disease and introduces what may be an important relationship of endogenous, excessive vasoactive amines to human coronary vasospasm.
D002275:Carcinoid Heart Disease / Q000150:complications* / Q000175:diagnosis; D003329:Coronary Vasospasm / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism; D006323:Heart Arrest / Q000175:diagnosis / Q000209:etiology*; D006632:Histamine; D006801:Humans; D008297:Male; D008303:Malignant Carcinoid Syndrome / Q000150:complications*; D008875:Middle Aged
D006632:Histamine