Empedopeptin (BMY-28117), a new depsipeptide antibiotic. II. Structure determination.
Structure of a new antibiotic, empedopeptin, has been determined. It is a cyclic depsipeptide composed of two mol of D-serine and one mol each of beta-hydroxytetradecanoic acid, L-arginine, D- and L-proline, L-3-hydroxyproline and D- and L-beta-hydroxyaspartic acid. The sequence of these moieties was established by partial hydrolysis and mass spectral analysis of the antibiotic.
D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D006868:Hydrolysis; D009842:Oligopeptides / Q000032:analysis*
D000900:Anti-Bacterial Agents; D009842:Oligopeptides; C043469:empedopeptin