[Effect of thyroid hormones on noradrenaline-stimulated lipolysis in obesity].
11 extremely adipose patients were over 4 days loaded with a noradrenalin infusion of 0.1 microgram/kg body weight/minute over 60 minutes before and after a daily application of 200 micrograms tri-iodothyronine. The determination of the free fatty acids and of glycerin resulted in a significant elevation basally as well as after stimulation with noradrenalin. Thus the lipolytic influence of the thyroid hormones is confirmed under in-vivo-conditions. The possible mechanisms of lipolysis in the fatty tissue are discussed on the basis of literature.
D000293:Adolescent; D000328:Adult; D004359:Drug Therapy, Combination; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D005990:Glycerol / Q000097:blood; D006801:Humans; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D009765:Obesity / Q000097:blood*; D014284:Triiodothyronine / Q000494:pharmacology*
D005230:Fatty Acids, Nonesterified; D014284:Triiodothyronine; D005990:Glycerol; D009638:Norepinephrine
Die Wirkung von Schilddrüsenhormonen auf die noradrenalinstimulierte Lipolyse bei Adipositas.