Family studies in multiple sclerosis: HLA haplotypes of affected sib-pairs.
The occurrence of multiple sclerosis (MS) in several members of families has been observed in 4.8% of 105 MS patients from a limited epidemiological area of Rostock. Typing of the HLA antigens in 4 affected sib-pairs showed two identical HLA haplotypes in 3 of the pairs: 1 pair shared one haplotype. These findings point to a dominant mode of inheritance of the disease susceptibility gene together with the HLA haplotype. The assessment of family studies in MS is discussed.
D000328:Adult; D002874:Chromosome Mapping; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D011995:Recombination, Genetic
D006680:HLA Antigens