Changes in the levels of marker expression by mononuclear phagocytes in zinc-deficient mice.
To define the effects of dietary zinc deficiency on mononuclear phagocytes young adult A/J mice were fed zinc-deficient, zinc-adequate, or restricted amounts of a zinc-adequate diet for 28 days. The deficiency did not affect the total number or the percentage of nonspecific esterase (NSE)-positive cell populations in the blood or peritoneal cavity of the mice; however, the total numbers of leukocytes and NSE-positive cells in the spleen were reduced in the deficient and restricted mice to about 50% of the zinc-adequate group. In the peripheral blood of deficient mice, the percentages of adherent cells expressing Fc (FcR) and complement (CR) receptors were five and two times greater, respectively, than zinc-adequate controls. The FcR-bearing cells of the spleens of zinc-deficient mice were also increased twofold over controls. Adherent cells from the peripheral blood and spleen of zinc-deficient mice were able to phagocytize a slightly greater number of latex particles than cells from the zinc-adequate or restricted mice. The presence of zinc in fetal bovine serum did not enhance the ability of mononuclear phagocytes from deficient mice to engulf latex in vitro.
D000818:Animals; D001835:Body Weight; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism; D002448:Cell Adhesion; D004032:Diet; D005260:Female; D007958:Leukocyte Count; D051379:Mice; D008805:Mice, Inbred A; D009000:Monocytes / Q000276:immunology / Q000502:physiology*; D010587:Phagocytosis; D011971:Receptors, Immunologic / Q000378:metabolism; D015032:Zinc / Q000172:deficiency*
D011971:Receptors, Immunologic; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase; D015032:Zinc