title: The effects of oral clonidine on the growth hormone level in acromegalic patients.
abstract: The effects of the noradrenergic agent clonidine on GH secretion of the adenohypophysis were studied in 10 healthy volunteers and 11 acromegalic patients. Orally administered clonidine led to a considerable serum human growth hormone (GH) level increase in the healthy individuals. In the acromegalic patients the clonidine resulted in a slight, but not significant GH increase. These results support the findings that the mechanism of noradrenergic regulation of serum GH secretion is impaired in acromegaly.
mesh_terms: D000172:Acromegaly / Q000503:physiopathology*; D000284:Administration, Oral; D000328:Adult; D003000:Clonidine / Q000008:administration & dosage; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010903:Pituitary Gland, Anterior / Q000503:physiopathology
chemical_list: D013006:Growth Hormone; D003000:Clonidine