Vancomycin ototoxicity in patients with normal renal function.
Three patients with normal renal function developed ototoxicity during vancomycin therapy. This is an uncommon occurrence and the literature is reviewed. Assumptions on "safe' levels of vancomycin are questioned.
D000328:Adult; D001301:Audiometry, Pure-Tone; D001309:Auditory Threshold / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced*; D006801:Humans; D007677:Kidney Function Tests; D008297:Male; D008875:Middle Aged; D010898:Pitch Perception / Q000187:drug effects; D011014:Pneumonia / Q000188:drug therapy; D013530:Surgical Wound Infection / Q000188:drug therapy; D014640:Vancomycin / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use
D014640:Vancomycin