[Varicose vein drugs--new attempts at objectivation of the effects of therapy].
The ultrasound Doppler examination has proved itself to be a very promising non-invasive method for the trials of vein medication under defined test conditions. In patients with postthrombotic syndrome the medium blood stream velocity in the V. femoralis increased on the diseased side two hours after oral application of a high-dosed combination of ruscogenin, trimethyl-hesperidin-chalkon and ascorbic acid (1 X 6 capsules Phlebodril) by the mean of 24%. If one observes the quotients from the middle arterial inflow and venous outflow velocity in the femoral vessels, in order to comprehend the relation between both these necessarily correlated hemodynamic parameters, one sees that this quotient shows a decrease after medication of 40%, which was significant on the 5% level. Corresponding drug effects in the early phase after getting upright could also be proved. The importance of these results, which are from an acute trial, must still be tested in a practical long-term therapy.
D001783:Blood Flow Velocity; D002599:Chalcone / Q000031:analogs & derivatives / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D005419:Flavonoids / Q000627:therapeutic use*; D006569:Hesperidin / Q000031:analogs & derivatives / Q000627:therapeutic use*; D006801:Humans; D010936:Plant Extracts / Q000627:therapeutic use*; D011187:Posture; D011427:Propiophenones / Q000627:therapeutic use*; D014648:Varicose Veins / Q000188:drug therapy*; D014689:Venous Insufficiency / Q000188:drug therapy*
D004338:Drug Combinations; D005419:Flavonoids; D010936:Plant Extracts; D011427:Propiophenones; C035564:phlebodril; D002599:Chalcone; D006569:Hesperidin
Venenpharmaka--neue Ansätze zur Objektivierung der Therapie-Effekte.