title: Factors influencing the release of noradrenaline from hypothalamic slices of the possum, Trichosurus vulpecula.
abstract: Slices of hypothalamus of the possum, Trichosurus vulpecula, were incubated with 3H noradrenaline and the subsequent spontaneous and K+-induced effluxes of 3H measured. Unchanged 3H noradrenaline comprised virtually all the K+-induced efflux, indicating that there was little, if any, metabolism of the amine after its release. Receptor-modulation of the K+-induced efflux of 3H was shown by inhibition of this efflux by noradrenaline, clonidine, angiotensin II and leu-enkephalin, and by the increase in efflux produced by yohimbine and isoprenaline. It is concluded that, in the possum, the control of spontaneous and K+-induced release of noradrenaline in the hypothalamus is similar to that in eutherian mammalian brain.
mesh_terms: D000818:Animals; D002395:Catecholamines / Q000494:pharmacology; D003000:Clonidine / Q000494:pharmacology; D005260:Female; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D008394:Marsupialia / Q000502:physiology*; D009638:Norepinephrine / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D015016:Yohimbine / Q000494:pharmacology
chemical_list: D002395:Catecholamines; D015016:Yohimbine; D003000:Clonidine; D011188:Potassium; D009638:Norepinephrine