Monoclonal idiotope vaccine against Streptococcus pneumoniae infection.
A monoclonal anti-idiotope antibody coupled to a carrier protein was used to immunize BALB/c mice against a lethal Streptococcus pneumoniae infection. Vaccinated mice developed a high titer of antibody to phosphorylcholine, which is known to protect against infection with Streptococcus pneumoniae. Measurement of the median lethal dose of the bacteria indicated that anti-idiotope immunization significantly increased the resistance of BALB/c mice to the bacterial challenge. Antibody to an idiotope can thus be used as an antigen substitute for the induction of protective immunity.
D000818:Animals; D000911:Antibodies, Monoclonal; D001428:Bacterial Vaccines; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010767:Phosphorylcholine / Q000276:immunology; D011008:Pneumococcal Infections / Q000517:prevention & control*; D013296:Streptococcus pneumoniae / Q000276:immunology; D014611:Vaccination
D000911:Antibodies, Monoclonal; D001428:Bacterial Vaccines; D007130:Immunoglobulin Idiotypes; D010767:Phosphorylcholine