title: Positive intradermal tests to D-tubocurarine in patients with cholinergic urticaria.
abstract: Patients with cholinergic urticaria exhibit increased hypersensitivity to cholinergic drugs. In the present study, an attempt was made to determine whether these patients would also cross-react to various neuromuscular blocking agents having structures analogous with acetylcholine. The four patients tested showed positive skin tests for D-tubocurarine at concentrations of 1/10,000. None of the 10 subjects in the control group and none of the patients with urticaria had positive responses, not even to a 10-fold higher concentration of D-tubocurarine. These findings suggest that caution should be exercised in the use of neuromuscular blocking agents in patients with cholinergic urticaria.
mesh_terms: D000293:Adolescent; D002648:Child; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000276:immunology; D006801:Humans; D008297:Male; D012882:Skin Tests; D014403:Tubocurarine / Q000009:adverse effects / Q000276:immunology*; D014581:Urticaria / Q000209:etiology / Q000276:immunology*
chemical_list: D014403:Tubocurarine