Use of lipids to potentiate the antibacterial activity of aminoglycosides.
Linolenyl alcohol has been shown to inhibit the in vitro growth of several species of gram-positive bacteria. Since the double bonds in linolenyl alcohol could undergo autooxidation, the antimicrobial activities of saturated primary alcohols of similar molecular sizes against Streptococcus mutans BHT were evaluated. Tridecan-1-ol was identified as the most active compound, eliciting a bacteriostatic effect at concentrations at which growth occurred in the presence of other saturated alcohols or linolenyl alcohol. Evidence is also presented that the combined use of tridecan-1-ol and gentamicin sulfate produces a synergistic effect that is bactericidal to S. mutans BHT. A similar bactericidal response was observed when tridecan-1-ol was combined with other aminoglycosides or tested alone against other strains of S. mutans.
D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D003470:Culture Media; D004357:Drug Synergism; D005233:Fatty Alcohols / Q000494:pharmacology*; D005839:Gentamicins / Q000494:pharmacology; D013295:Streptococcus mutans / Q000187:drug effects
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003470:Culture Media; D005233:Fatty Alcohols; D005839:Gentamicins; C037936:linolenyl alcohol