title: Utilization of chlorhexidine gluconate to evaluate a nonhuman primate skin-degerming model.
abstract: We have developed a nonhuman skin-degerming model to predict the in vivo effectiveness of topical antimicrobial formulations. The model incorporates a balanced, randomized, complete block design and uses the hands of anesthetized cynomolgus monkeys as treatment sites to measure product effectiveness. Two different 4% chlorhexidine gluconate formulations were evaluated in the primate model and then retested in a human skin-degerming model of identical design. Statistical analysis of the data revealed no significant differences between the two models with regard to the response exhibited by each to the test formulations.
mesh_terms: D000287:Administration, Topical; D000704:Analysis of Variance; D000818:Animals; D001419:Bacteria / Q000187:drug effects / Q000302:isolation & purification; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004202:Disinfectants; D005260:Female; D006225:Hand; D006801:Humans; D008251:Macaca / Q000382:microbiology*; D008252:Macaca fascicularis / Q000382:microbiology*; D008297:Male; D008954:Models, Biological; D012867:Skin / Q000382:microbiology*
chemical_list: D004202:Disinfectants; C010882:chlorhexidine gluconate; D002710:Chlorhexidine