Impact of scorpion Heterometrus fulvipes venom on cholinesterase rhythmicity in the tropical mouse Mus booduga.
Rhythmicities of acetylcholine (ACh) and acetylcholinesterase (AChE) were studied in the mouse, Mus booduga (Gray), following intramuscular injection of scorpion, Heterometrus fulvipes (C. Koch) venom. Envenomation inhibited the activity levels of ACh and AChE in all the tissues selected for experimentation. Control animals exhibited diel rhythmicity in ACh and AChE while envenomated animals showed fluctuation in the Phase (delta phi), amplitude (A), Acrophase (phi) and the extreme activity hours (X and X1).
D000109:Acetylcholine / Q000378:metabolism*; D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D002800:Cholinesterase Inhibitors; D002940:Circadian Rhythm / Q000187:drug effects*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism; D012604:Scorpion Venoms / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D012604:Scorpion Venoms; D000110:Acetylcholinesterase; D000109:Acetylcholine