Determination of sodium levothyroxine in bulk, tablet, and injection formulations by high-performance liquid chromatography.
Sodium levothyroxine was determined in bulk drugs, tablets, and injections by high-performance liquid chromatography (HPLC). Levothyroxine was separated from excipients and impurities on a 10-microns cyanoalkyl column using an acetonitrile-water-phosphoric acid mobile phase. The HPLC method is shown to be linear, accurate, and precise, and the results obtained by the HPLC and USP XX methods are compared.
D002851:Chromatography, High Pressure Liquid; D005612:Freeze Drying; D007267:Injections; D011208:Powders; D012996:Solutions; D013607:Tablets; D013974:Thyroxine / Q000032:analysis*
D011208:Powders; D012996:Solutions; D013607:Tablets; D013974:Thyroxine