D-amphetamine and DL-alpha-N-methyltryptamine eliminate the irreversible inhibition of mitochondrial monoamine oxidase, caused by clorgyline. The specific action on the tyramine oxidation.
A new hitherto unknown important property of D-amphetamine (but not L-isomer) and DL-alpha-N-methyltryptamine was discovered. These substances decrease the irreversible inhibition by clorgyline of tyramine deamination without affecting a sharply expressed inhibitory effect of clorgyline on serotonin oxidation. As a result of such a directed increase of selectivity, clorgyline became a still more highly specific inhibitor of serotonin oxidation without affecting, even at relatively high concentrations, tyramine deamination.
D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D003010:Clorgyline / Q000037:antagonists & inhibitors*; D003913:Dextroamphetamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000037:antagonists & inhibitors*; D010084:Oxidation-Reduction; D011437:Propylamines / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D013237:Stereoisomerism; D014363:Tryptamines / Q000494:pharmacology*; D014439:Tyramine / Q000378:metabolism*
D008996:Monoamine Oxidase Inhibitors; D011437:Propylamines; D014363:Tryptamines; D012701:Serotonin; C015293:indopan; D003010:Clorgyline; D003913:Dextroamphetamine; D014439:Tyramine