[Antibody-dependent cell cytotoxicity and the effect of interferon on K-cell functional activity in vitro in chronic viral hepatitis B in children].
Antibody-dependent cell-mediated cytotoxicity (ADCC) and in-vitro effect of interferon (IF) on the K cell activity was investigated in children with chronic hepatitis B (CHB) and normal donors. The ADCC in CHB was significantly decreased under normal values. The low K cell activity in CHB might determine inadequate elimination of infected liver cells and continuation of hepatitis B virus replication. IF in vitro significantly stimulated the ADCC of normal blood donors but was unable to significantly increase the ADCC of CHB patients. The in-vitro stimulation of the ADCC of normal donors by IF might be a phenomenon due to an increase of the adult K cell cytotoxic potential and/or activation of pre-K cell maturation. The lack of in-vitro augmentation of the ADCC of CHB patients by IF might result from the decreased quantity of K cells of pre-K cells in the peripheral blood and/or their low susceptibility to the stimulating effect of IF.
D000293:Adolescent; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects*; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004353:Drug Evaluation, Preclinical; D006509:Hepatitis B / Q000276:immunology*; D006521:Hepatitis, Chronic / Q000276:immunology; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*
D007370:Interferon Type I
Sostoianie antitelozavisimoĭ kletochnoĭ tsitotoksichnosti i vliianie interferona na funktsional'nuiu aktivnost' K-kletok in vitro pri khronicheskom virusnom gepatite B u deteĭ.