Measurement of tyramine in human plasma, utilising ion-pair extraction and high-performance liquid chromatography with amperometric detection.
An assay for plasma tyramine has been developed which uses ion-pair extraction, reversed-phase ion-pair high-performance liquid chromatography and amperometric detection. Tritiated tyramine is used as the internal standard. The method can measure down to 0.5 ng/ml of tyramine in 1 ml of human plasma and is thus suitable for monoamine oxidase inhibitor studies involving oral dosing with tyramine.
D000499:Allylamine / Q000031:analogs & derivatives / Q000494:pharmacology; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002852:Chromatography, Ion Exchange / Q000379:methods; D004566:Electrodes; D006801:Humans; D007202:Indicators and Reagents; D010080:Oxazoles / Q000494:pharmacology; D023303:Oxazolidinones; D014439:Tyramine / Q000097:blood*
D007202:Indicators and Reagents; D010080:Oxazoles; D023303:Oxazolidinones; D000499:Allylamine; C040051:2-(3,4-dimethoxyphenyl)-3-fluoroallylamine; C026234:cimoxatone; D014439:Tyramine