Enflurane, isoflurane and the eye.
The intra-ocular pressure was monitored in ophthalmological patients in whom nitrous oxide/oxygen anaesthesia was supplemented with an inspired concentration of 1% enflurane (10 patients) or 0.7% isoflurane (10 patients). These concentrations are proportionate to 0.6 MAC in oxygen. Both agents caused a significant decrease in intra-ocular pressure, enflurane by a mean of 3.1 mmHg (0.4 kPa) and isoflurane by 2.1 mmHg (0.3 kPa). There was no significant difference between agents. Isoflurane offers an alternative to enflurane in surgery when intra-ocular pressure is of importance.
D000328:Adult; D000368:Aged; D000768:Anesthesia, General; D001784:Blood Gas Analysis; D001794:Blood Pressure / Q000187:drug effects; D004737:Enflurane / Q000009:adverse effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D007530:Isoflurane / Q000009:adverse effects*; D008738:Methyl Ethers / Q000009:adverse effects*; D008875:Middle Aged; D013508:Ophthalmologic Surgical Procedures; D011897:Random Allocation
D008738:Methyl Ethers; D004737:Enflurane; D007530:Isoflurane