Vasoactive intestinal polypeptide (VIP) in cerebrospinal fluid from men after long-term exposure to organic solvents.
Vasoactive intestinal polypeptide (VIP) is widely distributed within the central nervous system (CNS) and is thought to function as a neurotransmitter. VIP was measured in CSF from 14 men with psycho-organic syndrome occupationally exposed to organic solvents for 7-38 years and in CSF from 8 neurologically healthy male volunteers. The concentration of VIP in the exposed group, 28 +/- 15 (SD) pmol/l, did not significantly differ from that of controls, 38 +/- 14 pmol/l. Thus, determination of VIP in CSF appears to be of little value for detecting effects of long-term solvent exposure.
D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000139:chemically induced*; D012997:Solvents / Q000506:poisoning*; D019966:Substance-Related Disorders / Q000134:cerebrospinal fluid*; D014660:Vasoactive Intestinal Peptide / Q000134:cerebrospinal fluid*
D012997:Solvents; D014660:Vasoactive Intestinal Peptide