Histological assessment of skin damage by irritants: its possible use in the evaluation of a 'barrier cream'.
The histological changes induced by topical application of selected irritants are reported. The possible application of this methodology to the evaluation of the protective value of a silicone-containing barrier cream is discussed. Although this crude method only allows objectivity of the later stages of a toxic reaction, it gives useful information about the potential protective effect of a silicone-containing barrier cream.
D000818:Animals; D004341:Drug Evaluation; D004655:Emulsions / Q000008:administration & dosage*; D005260:Female; D006168:Guinea Pigs; D007509:Irritants / Q000009:adverse effects*; D008899:Mineral Oil / Q000009:adverse effects; D009824:Ointments; D012828:Silicones / Q000008:administration & dosage*; D012833:Siloxanes / Q000008:administration & dosage*; D012867:Skin / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology / Q000517:prevention & control*; D012967:Sodium Dodecyl Sulfate / Q000009:adverse effects; D012972:Sodium Hydroxide / Q000009:adverse effects; D013262:Stevens-Johnson Syndrome / Q000209:etiology / Q000517:prevention & control; D014050:Toluene / Q000009:adverse effects
C043599:Cophasil; D004655:Emulsions; D007509:Irritants; C043700:Kubitrac; D009824:Ointments; D012828:Silicones; D012833:Siloxanes; D012967:Sodium Dodecyl Sulfate; D014050:Toluene; D012972:Sodium Hydroxide; D008899:Mineral Oil