Plasma vasopressin, cortisol, and growth hormone concentrations in relation to surgery in the suprasellar region.
Posterior and anterior pituitary functions were assessed in 8 patients before, during, and after surgery for tumors in the suprasellar region. Preoperatively, all patients but one responded adequately to an osmotic stimulus with a rise in plasma vasopressin (AVP) and all but one showed adequate cortisol response to adrenocorticotropic hormone (ACTH) and hypoglycemia. During surgery a transient rise was seen in plasma levels of AVP (5 out of 8 patients), cortisol (7 out of 8 patients) and growth hormone (4 out of 8 patients). This response could be predicted from the preoperative stimulation tests. Postoperatively the AVP response to osmotic stimuli was impaired in 4 out of 5 patients, although urine volume had returned to normal after a transient polyuric phase. The response of plasma cortisol to ACTH was still adequate but lower than preoperatively.
D000236:Adenoma / Q000097:blood / Q000601:surgery; D000328:Adult; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008579:Meningioma / Q000097:blood / Q000601:surgery; D008875:Middle Aged; D009994:Osmolar Concentration; D010911:Pituitary Neoplasms / Q000097:blood / Q000601:surgery; D012658:Sella Turcica / Q000601:surgery*; D012888:Skull Neoplasms / Q000097:blood / Q000601:surgery; D014667:Vasopressins / Q000097:blood*
D014667:Vasopressins; D013006:Growth Hormone; D006854:Hydrocortisone