title: The effects of cigarette smoking on pain and anxiety.
abstract: The antinociceptive and anxiolytic consequences of smoking a nicotine-containing cigarette or a zero-nicotine cigarette were investigated in minimally deprived habitual smokers, using a within-subject design. Five subjects were studied in each of two experiments. In one, pain was induced using the cold pressor test; in the other, anxiety, using unsolvable anagrams. All subjects exhibited pain- and anxiety-reduction after smoking a nicotine-containing cigarette. The results support the hypothesis that nicotine from smoking can produce psychological changes that are independent of the state of nicotine withdrawal.
mesh_terms: D000328:Adult; D001007:Anxiety / Q000503:physiopathology*; D003080:Cold Temperature; D006801:Humans; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D010146:Pain / Q000503:physiopathology*; D012684:Sensory Thresholds / Q000187:drug effects; D012907:Smoking; D014029:Tobacco Use Disorder / Q000503:physiopathology
chemical_list: D009538:Nicotine