Vitamin D metabolism and bone histomorphometry in a patient with antacid-induced osteomalacia.
A patient with hypophosphatemic osteomalacia secondary to ingestion of large amounts of phosphate-binding antacids is presented. Vitamin D metabolites were measured during the course of his illness and recovery and demonstrated an initially elevated concentration of 1,25-dihydroxyvitamin D, an undetectable level of 24,25-dihydroxyvitamin D, and a normal level of 25-hydroxyvitamin D. These metabolites returned to normal levels when the hypophosphatemia was corrected. Bone histomorphometry showed osteomalacia with increased resorption. The possible role of altered vitamin D metabolism in the pathogenesis of this disorder is discussed.
D000368:Aged; D000863:Antacids / Q000009:adverse effects*; D000886:Anthropometry; D001706:Biopsy; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood / Q000378:metabolism; D007866:Leg; D008297:Male; D010018:Osteomalacia / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000378:metabolism; D010710:Phosphates / Q000097:blood; D011859:Radiography; D014807:Vitamin D / Q000378:metabolism*
D000863:Antacids; D006887:Hydroxycholecalciferols; D010710:Phosphates; D014807:Vitamin D