Bis(3,5-diisopropylsalicylato)copper(II), a potent radioprotectant with superoxide dismutase mimetic activity.
Superoxide disproportionation may partially account for the noteworthy radioprotectant activity of bis(3,5-diisopropylsalicylato)copper(II) [CuII(3,5-dips)2]. Groups of mice treated with CuII(3,5-dips)2 3 or 24 h before exposure to a lethal dose of gamma-radiation had survival rates of 33% and 58%, respectively. These results suggest that copper complexes might be developed for protection of normal tissues in association with cancer radiotherapy and protection against occupational exposures to hazardous radiation.
D000818:Animals; D003037:Cobalt Radioisotopes; D005260:Female; D007202:Indicators and Reagents; D051379:Mice; D008815:Mice, Inbred Strains; D011837:Radiation-Protective Agents / Q000138:chemical synthesis*; D012459:Salicylates / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship; D013482:Superoxide Dismutase / Q000378:metabolism*
D003037:Cobalt Radioisotopes; D007202:Indicators and Reagents; D011837:Radiation-Protective Agents; D012459:Salicylates; C030865:copper bis(3,5-diisopropylsalicylate); D013482:Superoxide Dismutase