Effect of anionic polymeric hydrogels on spermatozoa motility.
The effects of a few synthetic polymers on the motility of human spermatozoa in vitro have been studied. An alternate copolymer of styrene and maleic anhydride, poly(S-MA), poly (styrene-maleic acid), poly(S-MC), poly(hydroxy-ethyl methacrylate-methacrylic acid) copolymer, poly(HEMA-MAC), poly(HEMA) homopolymer and poly(MAC) homopolymer were chosen for this purpose. It was found that all the carboxylic acid containing polymers are strong inhibitors of the motility of spermatozoa. Poly(HEMA) did not have any inhibitory effect on the motility of spermatozoa.
D003272:Contraceptive Agents, Male; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008298:Maleates / Q000494:pharmacology; D008299:Maleic Anhydrides / Q000494:pharmacology; D011108:Polymers / Q000494:pharmacology*; D011109:Polymethacrylic Acids / Q000494:pharmacology; D011137:Polystyrenes / Q000494:pharmacology; D013081:Sperm Motility / Q000187:drug effects*; D013329:Structure-Activity Relationship
D003272:Contraceptive Agents, Male; D008298:Maleates; D008299:Maleic Anhydrides; D011108:Polymers; D011109:Polymethacrylic Acids; D011137:Polystyrenes; C030613:polymethacrylic acid; C024074:styrene-maleic acid polymer; C025704:Styromal