The effect on pregnancy of treatment with antibodies against pregnancy-associated murine protein I (PAMP-I) in inbred and outbred mice.
Intravenous injection of small amounts of monospecific rabbit IgG against pregnancy-associated murine protein I (PAMP-I) induced abortion in mice where there was a histocompatibility difference between mother and fetuses. No abortion could be induced in inbred mice by a similar treatment. The maternal serum level was found to be higher in inbred than in outbred mice. The abortive dose of antibodies did not influence the serum levels of PAMP-I. Histological examination of uterine, placental and liver tissue showed only morphological changes in the placental tissue of mice which aborted due to the treatment with anti-PAMP-I antibodies.
D000022:Abortion, Spontaneous / Q000209:etiology; D000818:Animals; D000906:Antibodies / Q000008:administration & dosage; D005260:Female; D006648:Histocompatibility; D051379:Mice; D008815:Mice, Inbred Strains; D010920:Placenta / Q000473:pathology; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000037:antagonists & inhibitors / Q000097:blood / Q000276:immunology*
D000906:Antibodies; D011257:Pregnancy Proteins; C033484:pregnancy-associated murine protein 1