Effect of hibernation on liver and kidney metabolism in 13-lined ground squirrels.
Metabolic rates and adenine nucleotide content of liver and kidney from hibernating ground squirrels were measured and compared to rats to study the biochemical adaptation to hibernation. High rates of renal and hepatic gluconeogenesis were observed in squirrels, particularly from propionate and glycerol compared to rat. During hibernation and starvation soluble phosphoenolpyruvate carboxykinase activity was increased in both liver and kidney. Although metabolic rates are decreased during hibernation the results suggest that the enzymic complement is maintained at high activity even during torpor.
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D004734:Energy Metabolism; D005260:Female; D005943:Gluconeogenesis; D006605:Hibernation; D007657:Ketone Bodies / Q000378:metabolism; D007672:Kidney Cortex / Q000378:metabolism*; D007684:Kidney Tubules / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D008392:Marmota / Q000502:physiology*; D009928:Organ Specificity; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000378:metabolism; D012589:Sciuridae / Q000502:physiology*; D013217:Starvation
D000227:Adenine Nucleotides; D007657:Ketone Bodies; D010729:Phosphoenolpyruvate Carboxykinase (GTP)