[Potentially bioactive pyrimidine derivatives. 1. 2-Amino-4-aryl-8-arylidene-3,4,5,6,7,8-hexahydroquinazoline].
Six condensed 2-amino-4-arylpyrimidines (1a-f) were synthesized by the base catalyzed reaction of some monoarylidenecycloalkanones and guanidine. The reaction of 2,6-diarylidenecyclohexanones with guanidine yielded 2-amino-4-aryl-3,4,5,6,7,8-hexahydroquinazolines which were stable only as salts 3a-j. The oxidation of 3a-j led to 2-amino-4-aryl-8-arylidene-5,6,7,8-tetrahydroquinazolines 4a-j.
D055598:Chemical Phenomena; D002621:Chemistry; D009682:Magnetic Resonance Spectroscopy; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared
D011799:Quinazolines
Potentiell bioaktive Pyrimidinderivate. 1. Mitteilung: 2-Amino-4-aryl-8-aryliden-3,4,5,6,7,8-hexahydrochinazoline.