Effect of chromium(III) on poly(dG-dC) conformation.
The interaction of chromium(III) with poly(dG-dC) inhibits the B to Z transition and results in the condensation of the polymer at high Cr/nucleotide ratios. At low Cr/nucleotide ratios chromium(III) enhanced the ability of ethanol to induce the B to Z transition of poly(dG-dC). The effects of chromium(III) on the conformation of DNA may be related to the carcinogenicity of chromium compounds.
D002857:Chromium; D002942:Circular Dichroism; D000431:Ethanol; D007700:Kinetics; D009690:Nucleic Acid Conformation; D011089:Polydeoxyribonucleotides
D011089:Polydeoxyribonucleotides; D002857:Chromium; C019530:poly(dC-dG); D000431:Ethanol