Delayed release peppermint oil capsules (Colpermin) for the spastic colon syndrome: a pharmacokinetic study.
Excretion of menthol (as glucuronide) from orally ingested peppermint oil contained in Colpermin was compared with oil contained in two soft gelatine capsules. Total 24 h urinary excretion of menthol was similar in the two formulations in healthy volunteers, but peak menthol excretion levels were lower and excretion delayed with Colpermin. Menthol excretion was reduced in ileostomy patients who took Colpermin and moderate amounts of unmetabolised menthol were recovered from the ileostomy effluent. This is consistent with Colpermin being a delayed-release form of peppermint oil.
D000293:Adolescent; D000328:Adult; D002214:Capsules; D003109:Colonic Diseases, Functional / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D007081:Ileostomy; D007700:Kinetics; D008297:Male; D036142:Mentha piperita; D008610:Menthol / Q000378:metabolism; D008875:Middle Aged; D009822:Oils, Volatile / Q000008:administration & dosage / Q000378:metabolism*; D010936:Plant Extracts / Q000008:administration & dosage / Q000378:metabolism*; D010938:Plant Oils
D002214:Capsules; D003692:Delayed-Action Preparations; D009822:Oils, Volatile; D010936:Plant Extracts; D010938:Plant Oils; D008610:Menthol; C015424:peppermint oil