Oral flunitrazepam in the prevention of local anaesthetic-induced convulsions in mice.
The present study determined whether oral flunitrazepam was effective reducing CNS toxicity of lidocaine and bupivacaine. Pretreatment of mice with flunitrazepam, 0.065-0.25 mg X kg-1, significantly reduced or prevented convulsions and mortality induced by lidocaine 106 and 209 mg X kg-1 or bupivacaine 58 and 90 mg X kg-1 injected intraperitoneally. The doses of flunitrazepam used did not cause measurable sedation in mice. The efficacy of oral flunitrazepam in preventing local anaesthetic-induced convulsions is similar to that previously reported by intraperitoneal or intramuscular injections in mice. Flunitrazepam could be useful for oral premedication of patients before regional anaesthesia.
D000284:Administration, Oral; D000779:Anesthetics, Local / Q000633:toxicity*; D000818:Animals; D002045:Bupivacaine / Q000633:toxicity; D005445:Flunitrazepam / Q000627:therapeutic use*; D008012:Lidocaine / Q000633:toxicity; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011229:Preanesthetic Medication; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*
D000779:Anesthetics, Local; D005445:Flunitrazepam; D008012:Lidocaine; D002045:Bupivacaine