Use of an electromechanical infusion pump for transfusion of platelet concentrates.
To determine whether platelet concentrates can be administered safely through electromechanical infusion devices, we studied stored platelet concentrates passed through one pump system (Abbott). We measured in vitro changes in platelet count and lactic dehydrogenase (LDH) and beta-thromboglobulin (beta-TG) release which occurred after passing the concentrates through the pump system. To compare in vivo survival, five normal volunteers were given an injection of autologous Indium-111-labeled platelet concentrates at two different times, once using platelets which had been passed through the pump system (test group) and once using platelet concentrates which had not (control group). In vitro studies showed no significant changes (p greater than 0.05) in platelet count, or in LDH or beta-TG release after passage through the pump system. In vivo platelet recovery at 2 hours was 39.8 +/- 4.7 percent (mean +/- 1 SD) for the control platelets and 40.7 +/- 9.3 percent for the platelets passed through the pump system (p greater than 0.05; n = 5). There was no significant difference in platelet survival measured in days between the control group and the test group using a linear (8.0 +/- 0.9 vs. 7.2 +/- 0.3), exponential (3.7 +/- 0.7 vs. 3.1 +/- 0.5), or multiple hit (5.4 +/- 2.3 vs. 4.8 +/- 1.0) (p greater than 0.05; n = 5) model. We conclude that this pump system is acceptable for use in clinical practice when control over volume and rate of platelet transfusion is important.
D001803:Blood Transfusion / Q000379:methods*; D006801:Humans; D007263:Infusions, Parenteral / Q000295:instrumentation*; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D010976:Platelet Count; D017713:Platelet Transfusion; D013954:Thyroglobulin / Q000032:analysis; D013997:Time Factors
D013954:Thyroglobulin; D007770:L-Lactate Dehydrogenase