Can functional reorganization of area 17 following monocular deprivation be modified by GM1 internal ester treatment?
It has been extensively reported that monocular exposure early in life leads to profound alterations in visual cortical areas, where the majority of cells become responsive only to the stimulation of the normal eye. We have investigated a possible effect of the monosialoganglioside internal ester, termed AGF2, on the neuronal cortical plasticity of the kitten's visual cortex following monocular deprivation. Results indicate that in monocularly deprived kittens treated with ganglioside the ocular dominance shift in favor of the normal eye is partially prevented.
D000818:Animals; D001927:Brain Diseases / Q000188:drug therapy; D002415:Cats; D007839:Functional Laterality; D005677:G(M1) Ganglioside / Q000627:therapeutic use*; D005732:Gangliosides / Q000627:therapeutic use*; D012683:Sensory Deprivation; D014785:Vision, Ocular; D014793:Visual Cortex
D005732:Gangliosides; D005677:G(M1) Ganglioside