Effect of dietary niacin supplementation on phlorhizin and 1,3-butanediol-induced ketonemia and hypoglycemia in steers.
1,3-Butanediol and phlorhizin were used to induce ketonemia and hypoglycemia in steers. Oral administration of butanediol increased blood beta-hydroxybutyrate (BHB) and plasma nonesterified fatty acids (NEFA) and decreased serum glucose. Subcutaneous injections of phlorhizin, given in addition to butanediol orally, further increased NEFA and BHB concentrations and decreased glucose. Dietary niacin supplementation of steers given phlorhizin and butanediol caused serum glucose concentration to increase and blood BHB and plasma NEFA concentrations to decrease.
D020155:3-Hydroxybutyric Acid; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002072:Butylene Glycols; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006885:Hydroxybutyrates / Q000097:blood; D007003:Hypoglycemia / Q000097:blood / Q000139:chemically induced / Q000188:drug therapy / Q000662:veterinary*; D007657:Ketone Bodies / Q000097:blood*; D008297:Male; D009525:Niacin / Q000627:therapeutic use*; D010695:Phlorhizin; D011247:Pregnancy
D001786:Blood Glucose; D002072:Butylene Glycols; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D007657:Ketone Bodies; D009525:Niacin; C028491:1,3-butylene glycol; D010695:Phlorhizin; D020155:3-Hydroxybutyric Acid