[Effect of phenformin and succinic acid on the transplacental carcinogenic effect of N-nitroso-N-ethylurea in rats].
The study was concerned with the influence of a long-term postnatal treatment with an antidiabetic biguanide-phenformin and a biologic stimulating agent-succinic acid upon the realization of transplacental carcinogenic effect of N-ethyl-N-nitrosourea (ENU) in rats. Phenformin treatment inhibited the development of induced tumors in the nervous system and kidneys, significantly decreased the total incidence and multiplicity of these tumors, the incidence of brain and spinal cord tumors and multiplicity of brain tumors. Succinic acid did not influence the transplacental carcinogenic effect of ENU.
D000818:Animals; D005038:Ethylnitrosourea; D005260:Female; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D008431:Maternal-Fetal Exchange; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000517:prevention & control; D009423:Nervous System Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D009607:Nitrosourea Compounds; D010629:Phenformin / Q000627:therapeutic use*; D011247:Pregnancy; D051381:Rats; D013386:Succinates / Q000627:therapeutic use*; D019802:Succinic Acid
D009607:Nitrosourea Compounds; D013386:Succinates; D019802:Succinic Acid; D010629:Phenformin; D005038:Ethylnitrosourea
Vliianie fenformina i iantarnoĭ kisloty na transplatsentarnyĭ kantserogennyĭ éffekt N-nitrozo-N-étilmocheviny u krys.