title: 2,4-Difluoroaniline and 4-fluoroaniline exposure: monitoring by methaemoglobin and urine analyses.
abstract: Two possible methods for monitoring exposure to 2,4-difluoroaniline and 4-fluoroaniline have been investigated: measurement of methaemoglobin content in blood and measurement of urinary metabolites. Experiments using rats dosed by the oral route as a model system show that measurement of methaemoglobin content provides a very rapid and simple monitoring method, but is not very sensitive. Measurement of the ortho-hydroxy metabolites of the two compounds, as their benzoxazole derivatives, provides a much more sensitive, but complicated technique. Details of both methods are presented.
mesh_terms: D000814:Aniline Compounds / Q000633:toxicity* / Q000652:urine; D000818:Animals; D004781:Environmental Exposure; D008297:Male; D008706:Methemoglobin / Q000032:analysis*; D008708:Methemoglobinemia / Q000209:etiology; D008991:Monitoring, Physiologic; D051381:Rats; D011919:Rats, Inbred Strains; D013464:Sulfuric Acids / Q000652:urine
chemical_list: D000814:Aniline Compounds; D013464:Sulfuric Acids; C043454:2,4-difluoroaniline; C043455:4-fluoroaniline; D008706:Methemoglobin