[Effect of ceruloplasmin on the growth of experimental tumors and proliferative activity of cells].
Exogenous ceruloplasmin influence on experimental tumour growth and intensity of normal and malignant cell proliferation in tissue culture was investigated. It was found that ceruloplasmin administration to animals with transplanted tumours caused a 25-50% inhibition of tumour growth. A growth inhibiting activity of ceruloplasmin observed in tissue culture at the concentration of 5 mg/ml was established. It is also shown that ceruloplasmin did not reduce the antitumour effect of cyclophosphamide.
D000418:Albumins / Q000494:pharmacology; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured; D002570:Ceruloplasmin / Q000097:blood / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D051379:Mice; D009374:Neoplasms, Experimental / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D051381:Rats; D012510:Sarcoma 180 / Q000097:blood / Q000188:drug therapy / Q000473:pathology
D000418:Albumins; D003520:Cyclophosphamide; D002570:Ceruloplasmin
Vliianie tseruloplazmina na rost éksperimental'nykh opukholeĭ i proliferativnuiu aktivnost' kletok.