[Experimental study of the teratogenicity and embryotoxicity of endodan].
An experiment was carried out on albino rats for the assessment of the effect, during gestation, of the fungicide endodan (ethylene - thiuram monosulphide) on the intrauterine and postnatal development of the progeny. A low teratogenic and embryotoxic activity was established after a single treatment with I/2 LD50 on 13 th gestation day. The preparation is with a pronounced cumulative effect in a daily administration of 1/5, 1/10 and 1/20 LD50, manifested by clinical symptomatics and lethality of a part of the pregnant animals. Via tests for the assessment of the behaviour, deviations in the functional state of the nervous system of the progeny were established, with no changes in the integral indices - viability and body weight gain during the postnatal period.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D002219:Carbamates; D004305:Dose-Response Relationship, Drug; D020964:Embryo Loss / Q000139:chemically induced; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D006540:Herbicides / Q000633:toxicity*; D008297:Male; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013844:Thiazoles / Q000633:toxicity*; D013997:Time Factors
D002219:Carbamates; D006540:Herbicides; D013844:Thiazoles; C010145:ethylene thiuram monosulfide
Eksperimentalno prouchvane na endodan za teratogennost i embriotoksichnost.