Gamma-carboxyglutamate in a neuroactive toxin.
The venom of a fish-hunting cone snail (Conus geographus) contains a novel toxin, the "sleeper" peptide, which induces a sleep-like state in mice when injected intracerebrally. We demonstrate that this peptide contains 5 mol of gamma-carboxyglutamate (Gla) in 17 amino acids. The amino acid sequence of the sleeper peptide is Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH2.
D015055:1-Carboxyglutamic Acid / Q000032:analysis*; D000595:Amino Acid Sequence; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D020916:Conotoxins; D005971:Glutamates / Q000032:analysis*; D009498:Neurotoxins / Q000302:isolation & purification*; D010446:Peptide Fragments / Q000032:analysis; D010455:Peptides / Q000302:isolation & purification*; D012908:Snails
D020916:Conotoxins; D005971:Glutamates; D009498:Neurotoxins; D010446:Peptide Fragments; D010455:Peptides; D015055:1-Carboxyglutamic Acid; C055407:conotoxin GV