[Nonenzymatic fibrinolytic reaction to the intravenous administration of small doses of Salmonella endotoxin to rabbits].
Intravenous injection of a low dose of Salmonella endotoxin (10 micrograms/kg bw) into rabbits results in an increase in the non-enzymatic fibrinolytic activity of blood at early stages of a pathological process followed by depression of this response at later stages of the pathology. At higher degrees of non-enzymatic fibrinolysis activation the morphological and ultrastructural changes in renal tissues caused by endotoxin injection are the least pronounced. Intravenous injection of heparin after injection of a lethal dose of Salmonella endotoxin (100-200 micrograms/kg) enhances non-enzymatic fibrinolysis activation and decreases the morphological and ultrastructural lesions in renal tissues.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004731:Endotoxins / Q000008:administration & dosage / Q000633:toxicity*; D005342:Fibrinolysis / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects / Q000648:ultrastructure; D011817:Rabbits; D012475:Salmonella; D013916:Thrombelastography
D004731:Endotoxins; D006493:Heparin
Reaktsiia nefermentativnogo fibrinoliza na vnutrivennoe vvedenie malykh doz sal'monelleznogo éndotoksina krolikam.