A comparison of mirex-induced liver growth to liver regeneration.
In intact rats given a single oral dose of mirex there was a dose-dependent increase in liver weight which peaked at 4 days. There were increases in hepatic RNA and protein, but DNA content per liver and DNA synthesis as measured by [3H]thymidine incorporation were unchanged. In partially hepatectomized rats dosed with mirex 24 h post-surgery, there was a dose-dependent increase in relative liver weight which peaked at 5 days. In partially hepatectomized rats simultaneously dosed with mirex, [3H]thymidine incorporation into DNA was unaltered. However, in rats dosed with mirex 24 h prior to partial hepatectomy, there was a 50% reduction in [3H]thymidine incorporation into hepatic DNA.
D000367:Age Factors; D000818:Animals; D004247:DNA / Q000378:metabolism; D006498:Hepatectomy; D006965:Hyperplasia; D006984:Hypertrophy; D007306:Insecticides / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008115:Liver Regeneration; D008297:Male; D008917:Mirex / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013936:Thymidine / Q000378:metabolism
D007306:Insecticides; D004247:DNA; D013936:Thymidine; D008917:Mirex