title: The colchicine experimental epileptic focus: an intracellular study.
abstract: A new experimental epileptic focus is described in which colchicine is topically applied to neocortex. Stable epileptiform discharges developed, with bursts of action potentials, coincident with the surface epileptiform events. There were depolarizing and hyperpolarizing neuronal potentials and glial depolarizations concomitantly with the surface epileptic spikes.
mesh_terms: D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology / Q000633:toxicity*; D003292:Convulsants; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced*; D008564:Membrane Potentials / Q000187:drug effects; D009457:Neuroglia / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D051381:Rats
chemical_list: D003292:Convulsants; D003078:Colchicine