title: [Effect of fluoride on the skeletal system].
abstract: The chronic fluoride intoxication in man and animal may cause so different diseases of the bones as osteosclerosis, osteomalacia, secondary hyperparathyroidism and osteoporosis--partly in combination. On the basis of own examinations and of literature an own theory is developed which tries to explain these 4 contrary findings on the bone. According to this theory the fluor dosage, the calcium and vitamin D deficiency, differences of the species, duration of the fluoride supply and an individual sensitiveness to fluoride play an important role. Fluor has an effect on the 3 constituents of bones: osteoblasts, osteoclasts and the bone material.
mesh_terms: D000367:Age Factors; D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000139:chemically induced*; D008903:Minerals / Q000378:metabolism; D010006:Osteoblasts / Q000187:drug effects; D010010:Osteoclasts / Q000187:drug effects; D010018:Osteomalacia / Q000139:chemically induced*; D010026:Osteosclerosis / Q000139:chemically induced*; D012969:Sodium Fluoride / Q000009:adverse effects*; D013045:Species Specificity
chemical_list: D008903:Minerals; D012969:Sodium Fluoride
vernacular_title: Wirkung von Fluor auf das Skelettsystem.