[DNA synthesis in the mono- and binuclear cells of regenerating rat liver after x-ray irradiation].
The effect of X-irradiation on the dynamics of DNA synthesis during the S-period in bi- and mononucleated of regenerating rat liver was studied autoradiographically and microphotometrically. Rats were treated with X-rays at doses 3.84 X 10(-2), 15.48 X 10(-2), and 30.96 X 10(-2) Kl/kg 23 hours after a partial hepatectomy, and were sacrificed one hour after irradiation. In the control liver the rate of DNA synthesis was the lowest at the beginning of the S-period and the highest at the last quarter of this period in both mono- and binucleated cells. The irradiation results in the inhibition of DNA synthesis mainly at the end of the S-period depending on doses employed. This inhibition was the same in bi- and mononucleated cells. In addition, the increase of correlation of the 3H-thymidine incorporation rate and DNA content was found between nuclei of binucleated cells after irradiation.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism* / Q000528:radiation effects; D004247:DNA / Q000096:biosynthesis* / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006498:Hepatectomy; D007399:Interphase / Q000528:radiation effects; D008099:Liver / Q000378:metabolism / Q000528:radiation effects; D008115:Liver Regeneration / Q000528:radiation effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004247:DNA
Sintez DNK v odno- i dvuiadernykh kletkakh regeneriruiushcheĭ pecheni krys posle rentgenovskogo oblucheniia.