The effect of high dose glucocorticoid therapy on immunoglobulin E in asthma.
Serum IgE levels were measured before and after high dose intravenous methylprednisolone therapy in 14 patients with severe asthma. Eight patients received methylprednisolone 125 mg every 6 hours, four received methylprednisolone 60 mg every 6 hours, and two patients received hydrocortisone 100 mg every 6 hours. In patients receiving the higher dose, in extrinsic asthma, and in those not recently receiving corticosteroids, total serum IgE levels tended to decrease within a short interval after corticosteroid therapy.
D000328:Adult; D000368:Aged; D001249:Asthma / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D004305:Dose-Response Relationship, Drug; D005541:Forced Expiratory Volume; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged
D007073:Immunoglobulin E; D008775:Methylprednisolone