[Effectiveness of radiotherapy and chemoradiotherapy of disseminated laryngeal cancer].
The results of therapy of 112 patients with squamous cell laryngeal carcinoma, Stage III, were analysed. All the patients were given gamma-beam therapy by a split course. The first group was composed of 29 patients who received radiotherapy alone, 33 patients of the 2nd group also received chemotherapy with methotrexate, 5 mg daily, and 50 patients of the 3rd group were given radiotherapy and methotrexate, 60 mg once a week. Somewhat better short- and long-term results were achieved in the 2nd group. Statistically significant difference was obtained depending on the immediate efficacy of radio- and chemotherapy: 5-year survival rates in complete tumor regression were 57.1 +/- 7,7%, and in the presence of a residual tumor 26.3 +/- 7.2%. Radiation reactions and complications were more frequently observed in patients on radiotherapy combined with methotrexate, 60 mg once a week.
D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D003131:Combined Modality Therapy; D005720:Gamma Rays; D006801:Humans; D007822:Laryngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use
D008727:Methotrexate
Effektivnost' luchevogo i khimioluchevogo lecheniia rasprostranennogo raka gortanii.