Simulation of the metabolism of absorbed energy-yielding nutrients in young sheep.
A mathematical model is described, which simulates the metabolism of absorbed nutrients (amino acids, acetic acid, butyric acid, glucose, lipid and propionic acid) in growing sheep. The basic assumption of the model is that each nutrient is partitioned between synthetic, oxidative or intermediate reactions with rates of reaction which are described using enzyme kinetics. These rates depend on the relationship between maximum reaction rates, constants of affinity and inhibition and the concentrations of metabolites as determined by the model. Synthetic reactions calculate fat and protein deposition while intermediate reactions involve the production of ATP and NADPH. There is a total of twelve state variables and the model, programmed in CSMP and ACSL, is solved by integration of twelve differential equations. The model calculates the efficiency of utilization of metabolizable energy for different nutrient inputs and the results may be interpreted in terms of fluxes through the metabolite pools. Simulations using inputs representing forage- and concentrate-based diets indicated decreased efficiency for the forage at high levels of intake and possible reasons for this were further studied in simulations where the inputs of protein and glucose were varied.
D000085:Acetates / Q000378:metabolism; D019342:Acetic Acid; D000596:Amino Acids / Q000378:metabolism; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001823:Body Composition; D002087:Butyrates / Q000378:metabolism; D020148:Butyric Acid; D004041:Dietary Fats / Q000378:metabolism; D004044:Dietary Proteins / Q000378:metabolism; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism; D006128:Growth; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D011422:Propionates / Q000378:metabolism; D012756:Sheep
D000085:Acetates; D000596:Amino Acids; D002087:Butyrates; D004041:Dietary Fats; D004044:Dietary Proteins; D011422:Propionates; D020148:Butyric Acid; D005947:Glucose; C029658:propionic acid; D019342:Acetic Acid