Antimycotic action of some amino-N-(5-pyrimidinyl)benzenesulfonamides.
2-, 3- and 4-amino-N-(6-amino-1,4-dihydro-4-oxo-2-mercapto (or alkylthio)-5-pyrimidinyl)benzenesulfonamides were synthesized and biologically tested on different strains of Candida albicans and Candida tropicalis. Some of the 4-aminoderivatives were also tested for antibacterial properties on numerous bacterial strains. Antimycotic activity of 4-amino compounds, expressed as MIC, is around 50 micrograms/ml and higher than that of both 2-amino- and 3-aminoderivatives. In all these compounds alkyl chain length does not seem to have any notable effects on biological activity, an exception being made for some aralkyl compounds. Antibacterial activity of 4-aminoderivatives is very low for all strains tested.
D000935:Antifungal Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D013424:Sulfanilamides / Q000138:chemical synthesis* / Q000494:pharmacology
D000935:Antifungal Agents; D011743:Pyrimidines; D013424:Sulfanilamides