The effects of disconnection on two phases of kindled frontal-cingulate motor seizures.
The effects of various central nervous system cuts on different aspects of behavioral convulsions were observed in separate groups of rats after kindling in the frontal-cingulate area. Cuts in the corpus callosum lateralized the main aspects of the convulsions whereas coronal and sagittal cuts had little effect. Horizontal cuts beneath the electrode eliminated the phase of the convulsions attributable to the neocortex, even at high-intensity stimulation, but permitted the phase attributable to subcortical seizures. Placement of DC lesions in the lateral thalamus or the red nucleus and brachium conjunctivum abolished the tonic component of the neocortical phase, indicating possible involvement of cerebellar circuitry.
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D003337:Corpus Callosum / Q000503:physiopathology; D004827:Epilepsy / Q000145:classification / Q000503:physiopathology* / Q000523:psychology; D005625:Frontal Lobe / Q000503:physiopathology*; D006179:Gyrus Cinguli / Q000503:physiopathology*; D007696:Kindling, Neurologic; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D009626:Terminology as Topic