Induction of host resistance to Brugia pahangi in jirds (Meriones unguiculatus) protected by chemoprophylaxis.
Jirds were given a chemoprophylactic inoculation of flubendazole (FMBZ) and then five injections of infective larvae of Brugia pahangi whilst still protected by the FMBZ. When the drug was thought to be non-effective the jirds (and controls) were given a challenge infection of B. pahangi larvae. By comparison with control jirds the treated-infected-challenged jirds had 40% fewer adult worms. The control treated-challenged jirds contained mostly sterile female worms showing that they were still partially protected by FMBZ but worms numbers were not significantly reduced as compared with untreated controls.
D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D002009:Brugia / Q000254:growth & development / Q000276:immunology*; D005260:Female; D005368:Filariasis / Q000276:immunology* / Q000469:parasitology / Q000517:prevention & control; D005370:Filarioidea / Q000276:immunology*; D005849:Gerbillinae; D007109:Immunity; D007114:Immunization; D007814:Larva / Q000276:immunology; D008297:Male; D008463:Mebendazole / Q000031:analogs & derivatives / Q000627:therapeutic use*; D008842:Microfilariae
D000969:Antinematodal Agents; D001562:Benzimidazoles; D008463:Mebendazole; C018945:flubendazole