Veno-occlusive liver disease after dacarbazine therapy (DTIC) for melanoma.
A case of veno-occlusive disease of the liver with fatal outcome after dacarbazine (DTIC) therapy for melanoma is reported. There was a fulminant clinical course from start of symptoms until death. At autopsy the liver was enlarged and firm with signs of venous congestion. Small- and medium-sized hepatic veins were blocked by thrombosis. Eosinophilic infiltrations were found around the vessels. Published cases from the literature are reviewed and pertinent features discussed.
D006502:Budd-Chiari Syndrome / Q000139:chemically induced* / Q000473:pathology; D003606:Dacarbazine / Q000009:adverse effects*; D006503:Hepatic Veins / Q000473:pathology; D006801:Humans; D008297:Male; D008545:Melanoma / Q000188:drug therapy*; D008875:Middle Aged; D009336:Necrosis
D003606:Dacarbazine