Silicon compounds as substrates and inhibitors of acetylcholinesterase.
Several trimethylsilyl derivatives were found to be ligands of acetylcholinesterase (acetylcholine acetylhydrolase, EC 3.1.1.7): trimethylsilylethyl acetate (III) and trimethylsilylmethyl acetate (V) are substrates of the enzyme, whereas trimethylsilylethanol (VIII) is a competitive inhibitor. The silicon compounds have kinetic parameters similar to those of their carbon analogues, except for trimethylsilylmethyl acetate, which is a substrate of acetylcholinesterase, whereas its carbon analogue is not susceptible to enzymic hydrolysis.
D001667:Binding, Competitive; D002800:Cholinesterase Inhibitors / Q000378:metabolism*; D007700:Kinetics; D012825:Silicon / Q000378:metabolism*; D014297:Trimethylsilyl Compounds / Q000378:metabolism* / Q000494:pharmacology
D002800:Cholinesterase Inhibitors; D014297:Trimethylsilyl Compounds; C043884:2-(trimethylsilyl)ethyl acetate; C043885:2-(trimethylsilyl)ethanol; C043886:2-(trimethylsilyl)methyl acetate; D012825:Silicon