Release of pentobarbital-induced depression of metabolic rate during bilateral ischemia in the gerbil brain.
Treatment of gerbils with 40 mg/kg of pentobarbital (i.p.) reduced the metabolic rate in the hippocampus and cerebral cortex by approximately 60%. However, the depression of metabolic rate was lost within 40 s of ischemia and further, pentobarbital delayed but did not prevent the depletion of energy metabolites observed in the ischemic brain.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects*; D005849:Gerbillinae; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D002546:Ischemic Attack, Transient / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D010725:Phosphocreatine / Q000378:metabolism
D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D006003:Glycogen; D010424:Pentobarbital; D005947:Glucose