Ca2+-transport in skeletal muscle sarcoplasmic reticulum of the chronically diabetic rat.
Ca2+-transport in fast skeletal muscle sarcoplasmic reticulum preparations was studied in experimentally-induced diabetic rats 90 days after treatment. A significant decrease in ATP-dependent oxalate facilitated Ca2+-uptake was observed in these animals at all free Ca2+ concentrations tested (0.1-2.0 microM). A concomitant elevation in the levels of both free carnitine and long-chain acylcarnitine was also found. These observations paralleled results obtained in diabetic rat heart sarcoplasmic reticulum preparations and suggest a generalized pathophysiological mechanism affecting muscle tissue function in the diabetic animal.
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D002331:Carnitine / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D008861:Microsomes / Q000378:metabolism; D009132:Muscles / Q000378:metabolism*; D051381:Rats; D012519:Sarcoplasmic Reticulum / Q000378:metabolism*
D002331:Carnitine; D002118:Calcium