title: Toxicity in utility pigeons caused by the coccidiostat dinitolmide.
abstract: Utility pigeons on 3 farms were affected by a severe neurological disturbance manifested by fine tremors, rolling gait and incoordination. Affected birds had necrosis of the Purkinje cells of the cerebellar cortex. The birds from the 3 farms had been fed a pelleted diet obtained from a single mix of feed prepared by a stockfeed manufacturer. When feed obtained from the farms was given to utility pigeons under controlled conditions at the laboratory, they suffered the same clinical signs and lesions as seen in birds from the farms. Cross-bred cockerels were not affected when given this feed from day-old to 6 weeks of age. Samples of the feed contained 185 to 226 ppm of the coccidiostat dinitolmide. Utility pigeons given a prepared diet containing a similar level (234 ppm) of dinitolmide developed an identical condition after 3 to 4 weeks feeding. Laying hens were not affected by this feed. Dimetridazole, which was also present in some of the original feed samples, did not exacerbate the condition when included in the diet at a rate of 233 ppm. Production of squabs from the affected farms was dramatically reduced, and many of the breeder had to be culled because of the long-standing neurological disease.
mesh_terms: D000821:Animal Feed; D000818:Animals; D001549:Benzamides / Q000009:adverse effects*; D001715:Bird Diseases / Q000139:chemically induced* / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D002645:Chickens; D010856:Columbidae; D004135:Dinitolmide / Q000009:adverse effects* / Q000633:toxicity; D005260:Female; D008297:Male; D009336:Necrosis; D009422:Nervous System Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D011201:Poultry Diseases / Q000139:chemically induced; D011689:Purkinje Cells / Q000473:pathology
chemical_list: D001549:Benzamides; D004135:Dinitolmide