title: Chemotherapy in combination with pelvic irradiation: a time-dependence study in mice.
abstract: The importance of timing of drug administration in combination with pelvic irradiation on animal lethality was investigated in male CBA mice. The chemotherapeutic agents cyclophosphamide, cytosine arabinoside, 5-fluorouracil, methotrexate, cis-dichlorodiammine platinum (II), adriamycin, CCNU, VP-16 and bleomycin were administered at various times up to 2 weeks before and 2 weeks after pelvic irradiation (4 weeks before and after in the case of cyclophosphamide) of unanaesthetised mice and the LD50/30 days and dose enhancement factors determined. The results indicate a potentiation of radiation-induced damage when drugs are given near to the time of irradiation, particularly at about 3 days post-irradiation.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010388:Pelvis / Q000528:radiation effects; D011878:Radiotherapy; D013997:Time Factors
chemical_list: D000970:Antineoplastic Agents