[Influence of carnosine on the immunosuppressive effect of histamine].
It has been demonstrated in experiments that histamine is capable of suppressing the antigen-induced proliferation of mouse spleen cells. This histamine effect was suppressed by its H-2 antagonist metiamide but not H-1 antagonist mepiramine. Carnosine exerted an action similar to metiamide, also inhibiting the histamine-caused suppression of murine lymphocyte proliferation. This makes it possible to classify it with the group of H-2-histamine blockers. The H-2-antihistamine properties exhibited by carnosine necessitate its further study as a new antiallergic drug.
D000818:Animals; D002336:Carnosine / Q000494:pharmacology*; D004151:Dipeptides / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology*; D007108:Immune Tolerance / Q000187:drug effects; D007166:Immunosuppressive Agents; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008785:Metiamide / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D011738:Pyrilamine / Q000494:pharmacology; D011970:Receptors, Histamine H2 / Q000187:drug effects / Q000276:immunology
D004151:Dipeptides; D007166:Immunosuppressive Agents; D011970:Receptors, Histamine H2; D008785:Metiamide; D006632:Histamine; D002336:Carnosine; D011738:Pyrilamine
Vliianie karnozina na immunosupressivnyĭ éffekt gistamina.