A test in vero cell monolayers for toxin production by strains of Pasteurella multocida isolated from pigs suspected of having atrophic rhinitis.
Monolayers of Vero cells showed a morphological change after exposure to supernatants of certain porcine Pasteurella multocida cultures. It appeared possible to screen Pasteurella multocida isolates for their ability to produce toxin and to cause atrophic rhinitis in pigs. A close correlation with the guinea pig skin test was demonstrated.
D000818:Animals; D001681:Biological Assay; D002460:Cell Line; D002522:Chlorocebus aethiops; D003885:Dermotoxins / Q000096:biosynthesis*; D006168:Guinea Pigs; D007668:Kidney; D010325:Pasteurella / Q000378:metabolism*; D012222:Rhinitis, Atrophic / Q000382:microbiology / Q000662:veterinary*; D012882:Skin Tests / Q000662:veterinary; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology*
D003885:Dermotoxins