Liquid crystals as a potential ointment vehicle.
A lecithin-water lyotropic liquid crystal was used as an ointment vehicle for a hydrocortisone formulation. The hydrocortisone was soluble in the liquid crystalline phase up to 5% by weight. The diffusion coefficient determined for the hydrocortisone in the liquid crystalline phase was 5.5 X 10(-9) cm X s-1, which is four magnitudes higher than the corresponding value for skin.
D002626:Chemistry, Pharmaceutical; D003460:Crystallization; D004058:Diffusion; D004355:Drug Stability; D006854:Hydrocortisone / Q000032:analysis; D007700:Kinetics; D009823:Ointment Bases; D010592:Pharmaceutic Aids; D014677:Pharmaceutical Vehicles; D012995:Solubility; D013816:Thermodynamics; D014961:X-Ray Diffraction
D009823:Ointment Bases; D010592:Pharmaceutic Aids; D014677:Pharmaceutical Vehicles; D006854:Hydrocortisone