title: Zomepirac sodium (Zomax) hypersensitivity in aspirin-sensitive asthmatics.
abstract: Three asthmatic patients with a history of bronchoconstriction after aspirin ingestion were challenged with a new analgesic, zomepirac sodium (Zomax), for determination of sensitivity to this drug. Each patient had previously demonstrated sensitivity to aspirin during oral provocative challenges. In all 3 patients, zomepirac produced the typical asthmatic and nasal response, indicating hypersensitivity. These findings indicate that zomepirac sodium is not tolerated in aspirin-sensitive asthmatics and should not be prescribed to such patients.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001241:Aspirin; D001249:Asthma / Q000150:complications* / Q000188:drug therapy; D004342:Drug Hypersensitivity / Q000150:complications*; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008875:Middle Aged; D011758:Pyrroles; D014046:Tolmetin / Q000031:analogs & derivatives
chemical_list: D000305:Adrenal Cortex Hormones; D011758:Pyrroles; C020549:zomepirac; D014046:Tolmetin; D001241:Aspirin