Mutagenicity of instant coffee on cultured Chinese hamster lung cells.
Coffee showed mutagenic activity in cultured Chinese hamster lung (CHL) cells as assessed by using diphtheria toxin resistance as a selective marker. Most of the mutagenicity was suppressed in the presence of sodium bisulfite. The contribution of methylglyoxal to the total mutagenicity of coffee was less than 3%.
D000447:Aldehydes / Q000633:toxicity*; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003069:Coffee / Q000633:toxicity*; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D009154:Mutation / Q000187:drug effects*; D010053:Ovary; D011765:Pyruvaldehyde / Q000633:toxicity*; D013447:Sulfites / Q000633:toxicity
D000447:Aldehydes; D003069:Coffee; D013447:Sulfites; D011765:Pyruvaldehyde; C009279:sodium bisulfite