Apomorphine and haloperidol-induced effects on male rat sexual behavior: no evidence for actions due to stimulation of central dopamine autoreceptors.
The administration of apomorphine (0.2-0.8 mg/kg IP) or (+)3-PPP(4-8 mg/kg IP) produced a facilitation of the male rat sexual behavior. Apomorphine in lower doses, as well as the selective DA autoreceptor agonist (-)3-PPP were ineffective. Except for a decrease in number of intromissions and an increase in the postejaculatory interval at the highest dose (0.32 mg/kg IP) there were no effects after administration of haloperidol. These data indicate that activation or inhibition of the presynaptic dopamine receptor does not affect male rat sexual behavior.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D010880:Piperidines; D011954:Receptors, Dopamine; C026539:preclamol; D006220:Haloperidol; D001058:Apomorphine