title: Cyclodextrin-stabilized volatile substances for inhalation therapy.
abstract: Diapulmon (Chinoin) which comprise camphor, 1-menthol, eucalyptus oil and quinine dissolved in sunflower oil (Oleum helianthi) is marketed in ampoules of 2 ml but utilized almost exclusively for inhalation therapy. Complexing the active ingredients of Diapulmon with beta-cyclodextrin (beta-CD) a stable non hygroscopic microcrystalline substance is obtained. When this powder sprinkled on hot water, the included volatile compounds are gradually released and the desired pharmacological effect can be brought about.
mesh_terms: D002164:Camphor / Q000032:analysis; D002849:Chromatography, Gas / Q000379:methods; D003505:Cyclodextrins; D003912:Dextrins; D004338:Drug Combinations / Q000032:analysis; D004355:Drug Stability; D005079:Excipients; D008610:Menthol / Q000032:analysis; D009822:Oils, Volatile / Q000032:analysis; D011803:Quinine / Q000032:analysis; D012138:Respiratory Therapy; D013213:Starch
chemical_list: D003505:Cyclodextrins; D003912:Dextrins; C043568:Diapulmon; D004338:Drug Combinations; D005079:Excipients; D009822:Oils, Volatile; D008610:Menthol; D002164:Camphor; D013213:Starch; D011803:Quinine