Platelet storage in glow discharge-treated polyvinylchloride bags: effects of a plasticizer on platelet hypotonic shock response.
The effect of a plasticizer (DEHP) of PVC blood bags on platelet response to hypotonic shock was examined. The response of the platelet concentrate (PC), stored in the bag in which DEHP elution was prevented by glow-discharge treatment, did not change until 72 h of storage. On the other hand, during PC storage in control bags or in plasma containing DEHP, the response decreased approximately linearly. The time course of DEHP incorporation into platelet agreed well with that of the decrease of the response to hypotonic shock.
D001792:Blood Platelets / Q000187:drug effects*; D001793:Blood Preservation / Q000295:instrumentation*; D001800:Blood Specimen Collection / Q000295:instrumentation*; D002462:Cell Membrane / Q000378:metabolism; D004051:Diethylhexyl Phthalate / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D007038:Hypotonic Solutions / Q000494:pharmacology; D009996:Osmotic Fragility; D010795:Phthalic Acids / Q000494:pharmacology*; D010968:Plasticizers / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects
D007038:Hypotonic Solutions; D010795:Phthalic Acids; D010968:Plasticizers; D004051:Diethylhexyl Phthalate