title: The role of the intestinal microflora in the reductive metabolism of acenocoumarol in man.
abstract: Although the oral anticoagulant acenocoumarol (AC) is very effectively metabolized by the intestinal microflora to its amino metabolite, under clinical conditions this route of AC-disposition is of no importance because the compound is rapidly absorbed from its pharmaceutical application form. Only when the gastro-intestinal absorption is retarded, for instance by using a capsule as vehiculum, are appreciable amounts of reduced metabolites recovered in urine.
mesh_terms: D000074:Acenocoumarol / Q000031:analogs & derivatives / Q000378:metabolism*; D001711:Biotransformation; D002214:Capsules; D006801:Humans; D007408:Intestinal Absorption; D007422:Intestines / Q000382:microbiology*; D008297:Male; D010084:Oxidation-Reduction
chemical_list: D002214:Capsules; D000074:Acenocoumarol