Conformation takes precedence over sequence in adeno-associated virus DNA replication.
Deletion of an 11-base symmetrical sequence in the inverted terminal repetition of the adeno-associated virus 2 genome inhibits DNA replication. Substitution of either an 8- or a 12-base symmetrical sequence unrelated to the original 11-base sequence restores DNA replication.
D000260:Adenoviruses, Human / Q000235:genetics*; D001483:Base Sequence; D002872:Chromosome Deletion; D003001:Cloning, Molecular; D004261:DNA Replication; D004279:DNA, Viral / Q000235:genetics*; D006801:Humans; D009690:Nucleic Acid Conformation; D010957:Plasmids; D014162:Transfection; D014779:Virus Replication
D004279:DNA, Viral