Selective deficits in the sense of smell caused by chemical modification of the olfactory epithelium.
A chemically selective procedure for covalent modification of Schiff base-forming binding sites in proteins is demonstrated in vitro. In vivo studies show that the same procedure produces a selective anosmia ("odor blindness") when applied to the olfactory epithelia of experimental animals. Surgical experiments confirm that the sense of smell is specifically affected.
D000557:Ambystoma; D000818:Animals; D001362:Avoidance Learning; D002490:Central Nervous System / Q000502:physiology*; D004193:Discrimination Learning; D004848:Epithelium / Q000502:physiology; D009666:Nose / Q000502:physiology; D009812:Odorants; D009832:Olfactory Nerve / Q000502:physiology; D009833:Olfactory Pathways / Q000502:physiology*; D012545:Schiff Bases; D012903:Smell
D012545:Schiff Bases