title: Experimental medication of equine ringworm due to Trichophyton equinum var. autotrophicum.
abstract: Twelve medicaments were tested for their efficacy in the treatment of Trichophyton equinum var. autotrophicum; povidone iodine, thiabendazole ointment, captan ointment and Burroughs Wellcome Ringworm Ointment gave satisfactory results but their usefulness may be limited for treatment of large numbers of horses. Aqueous washes containing 0.5% hexetidine or 0.3% chloramine-T did not prevent fungi being isolated from lesions for up to 7 days after treatment. Similarly neither etisazole nor thiabendazole suspension prevented fungi from being isolated from lesions for up to 15 days after treatment. Commonly used aqueous solution of 2.5% lime sulphur and 2% captan were least successful, as fungi could still be isolated from lesions for up to 30 days after treatment. The need to treat large numbers of horses may dictate the use of such solutions rather than ointments because of ease of application and cost factors. Treatments consisting of 10% nystatin ointment, 10% iodine fortis, 10% Medol and a proprietary ointment, Queensland Itch Dressing, were not satisfactory. Clinical appraisal and a scratch test must be used together to evaluate progress of treatment. Mass medication of large numbers of horses should be primarily aimed at reduction of spread of infection; normal hair growth should not be used as an indication of the removal of infective agents in the hair as regrowth was altered very little by medication. Hence assessments of cure on the basis of regrowth of hair alone are of dubious value.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006197:Hair / Q000254:growth & development; D006734:Horse Diseases / Q000188:drug therapy* / Q000503:physiopathology; D006736:Horses; D009824:Ointments; D014005:Tinea / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*
chemical_list: D000891:Anti-Infective Agents, Local; D000935:Antifungal Agents; D009824:Ointments