title: [Diffusion of tetroxoprim and sulfadiazine in the cerebrospinal fluid of neurosurgery patients].
abstract: Two studies were conducted in neurosurgical patients to establish cerebrospinal fluid (CSF) and plasma levels of tetroxoprim (TXP) and sulphadiazine (SDZ) following the oral administration of co-tetroxazin in a standard dosage regimen. Both TXP (0,62-0,42 micrograms/ml) and SDZ (2,5-4,5 micrograms/ml) adequately penetrated into the CSF, resulting in concentrations above the MICs for most relevant pathogens. In relation to the respective plasma levels and under steady state conditions, CSF-availability is 37,5% for TXP and 31,8% for SDZ.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000134:cerebrospinal fluid*; D001927:Brain Diseases / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011743:Pyrimidines / Q000097:blood / Q000134:cerebrospinal fluid*; D013411:Sulfadiazine / Q000097:blood / Q000134:cerebrospinal fluid*
chemical_list: D000890:Anti-Infective Agents; D011743:Pyrimidines; D013411:Sulfadiazine; C023507:tetroxoprim
vernacular_title: Diffusion von Tetroxoprim und Sulfadiazin in den Liquor cerebrospinalis bei neurochirurgischen Patienten.