title: Stimulation of crop sac and pituitary lactotrophs after intraventricular administration of dermorphin in pigeons.
abstract: The effects of dermorphin, a new potent opioid peptide, on structural and ultrastructural changes in the crop sac and in pituitary lactotrophs were assessed in pigeons (Columba livia). A single administration of dermorphin into the third cerebral ventricle (1 microgram) and the same dose repeated for 3 consecutive days both produced maximal crop sac stimulation, as documented by the presence of milk-like material as well as by scanning and transmission electron microscopy of crop sac mucosa. In addition, marked stimulatory effects were also observed in pituitary lactotrophs, as shown by stimulation of Golgi apparatus, enlargement of rough endoplasmic reticulum, increase in mitochondria size, and the presence of lysosomes and electron-opaque granules. The stimulatory effects of dermorphin on the crop sac and lactotrophs were completely prevented by naloxone, an antagonist at opiate receptors. Since dermorphin is a natural constituent of the avian brain, it has been suggested that this peptide may represent the still-obscure hypothalamic prolactin stimulatory factor.
mesh_terms: D000818:Animals; D010856:Columbidae / Q000378:metabolism*; D003426:Crop, Avian / Q000187:drug effects*; D005260:Female; D007276:Injections, Intraventricular; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009270:Naloxone / Q000494:pharmacology; D009842:Oligopeptides / Q000008:administration & dosage / Q000494:pharmacology*; D018847:Opioid Peptides; D010903:Pituitary Gland, Anterior / Q000166:cytology* / Q000187:drug effects; D011388:Prolactin / Q000378:metabolism*
chemical_list: D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin; D009270:Naloxone; D011388:Prolactin