[Hydrochlorides of N-hydroxyalkyl-alpha-piperidine carboxylic arylamides possessing antiarrhythmic activity].
It has been demonstrated in experimental arrhythmias of animals (aconitine one in rats, strophanthine in guinea-pigs, creation of an "ectopic focus of excitation" in cats by electric stimulation) that new compounds, the derivatives of piperidine carboxylic acids, possess antiarrhythmic activity. In doses of 6-23 mg/kg, the compounds under study prevented the development of the mixed type arrhythmia induced by intravenous injection of aconitine, prolonged the time of survival and prevented the animals' death during intravenous injection of the arrhythmogenic doses of strophanthine, prolonged the refractory period, and increased the threshold of ventricular fibrillation in cats. As regards the power of the antiarrhythmic effect, the compounds under study--hydrochlorides of arylamides of N-hydroxyalkly-alpha-piperidine carboxylic acids--approach lidocaine, yield to marcaine, and exhibit a broader range of therapeutic action.
D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use* / Q000633:toxicity; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D002415:Cats; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation; D006168:Guinea Pigs; D051379:Mice; D010875:Pipecolic Acids / Q000627:therapeutic use* / Q000633:toxicity; D051381:Rats; D013328:Strophanthins; D014693:Ventricular Fibrillation / Q000188:drug therapy / Q000209:etiology
D000889:Anti-Arrhythmia Agents; D010875:Pipecolic Acids; D013328:Strophanthins; D000157:Aconitine
Khlorgidraty nekotorykh arilamidov N-oksialkil-al'fa-piperidinkarbonovykh kislot, obladaiushchie antiaritmicheskoĭ aktivnost'iu.