Cerebellar ataxia due to procainamide toxicity.
It has become appreciated that drug levels of procainamide hydrochloride needed to suppress inducible ventricular tachycardia by programmed ventricular stimulation exceed the previously published therapeutic range. Cerebellar ataxia developed acutely in a patient receiving high-dose procainamide. This was associated with a marked increase in the serum drug level. Resolution occurred within three days after drug therapy was discontinued.
D000284:Administration, Oral; D002524:Cerebellar Ataxia / Q000139:chemically induced*; D004334:Drug Administration Schedule; D006352:Heart Ventricles; D006801:Humans; D008297:Male; D008875:Middle Aged; D011342:Procainamide / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D013610:Tachycardia / Q000188:drug therapy
D011342:Procainamide