title: Identification of class I major histocompatibility complex encoded molecules in the amphibian Xenopus.
abstract: Class I-like molecules have been immunoprecipitated from Xenopus leukocytes and erythrocytes with alloantisera directed against major histocompatibility complex (MHC)-linked antigens. The heavy chains, depending on the allele examined, have molecular weights of 40 000-44 000 of which 3000 daltons are asparagine-linked carbohydrates, probably present as one N-linked glycan. The presumed analogue of beta 2-microglobulin has a molecular weight of 13 000 and bears no asparagine-linked glycans. Family studies show that the heavy chains are encoded by genes residing in or closely linked to the MHC.
mesh_terms: D000483:Alleles; D000818:Animals; D004912:Erythrocytes / Q000276:immunology; D006023:Glycoproteins / Q000276:immunology; D006649:Histocompatibility Antigens / Q000235:genetics* / Q000276:immunology; D006824:Hybridization, Genetic; D007526:Isoelectric Point; D007962:Leukocytes / Q000276:immunology; D008285:Major Histocompatibility Complex; D008970:Molecular Weight; D014981:Xenopus / Q000276:immunology*
chemical_list: D006023:Glycoproteins; D006649:Histocompatibility Antigens