Tissue-specific induction of intestinal glutathione S-transferases by alpha beta-unsaturated carbonyl compounds.
Glutathione S-transferase activity in rat intestinal mucosa was increased by the injection of alpha beta-unsaturated carbonyl compounds such as phorone and diethylmaleate, but that in the liver and kidney was not. Since the administration of cycloheximide completely blocked the increase of the enzyme activity by phorone, the increase of the activity may be due to de novo synthesis rather than enzyme activation.
D000818:Animals; D004790:Enzyme Induction / Q000187:drug effects; D005982:Glutathione Transferase / Q000096:biosynthesis*; D007413:Intestinal Mucosa / Q000201:enzymology*; D007659:Ketones / Q000494:pharmacology*; D007668:Kidney / Q000201:enzymology; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D008297:Male; D008298:Maleates / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D007659:Ketones; D008298:Maleates; C018637:phorone; D005982:Glutathione Transferase; C014476:diethyl maleate