Creatine kinase isoenzymes in serum from children--especially focusing on CK-BB.
In 161 children with ages ranging from 7 months to 18 years the concentration of CK-BB in serum was measurable in 58%. The activity in serum of CK-BB (cCK-BB(S] in children varies with age and is not significantly influenced by seizure, epilepsy or body temperature. The values are most elevated during the first year of life and show a rapid fall, never reaching adult levels. Comparing mean cCK-BB(S) values in children to growth charts the resemblance is striking. CK-BB is the only CK-isoenzyme that changes with age. We postulate that cCK-BB(S) is related to growth as a physiological phenomenon. CK-MB was found in serum in 7% of the children and could not be of cardiac origin. Therefore CK-MB cannot be regarded as cardiac specific in children.
D000293:Adolescent; D000367:Age Factors; D001831:Body Temperature; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood*; D006128:Growth; D006801:Humans; D007223:Infant; D007527:Isoenzymes; D012016:Reference Values; D012640:Seizures / Q000201:enzymology
D007527:Isoenzymes; D003402:Creatine Kinase