[A study on the enhancement of pulmonary metastasis by intra-arterial adriamycin in Lewis lung carcinoma].
Intra-arterial adriamycin was shown to enhance the spontaneous production of pulmonary metastases from the primary subcutaneous tumor in mice. This enhancement of metastasis was not observed in mice treated with adriamycin intravenously. These results suggest that the enhancement of metastasis is induced by vascular damage in tumor tissue under a high concentration of adriamycin.
D000818:Animals; D004317:Doxorubicin / Q000008:administration & dosage* / Q000009:adverse effects; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D008175:Lung Neoplasms / Q000556:secondary*; D051379:Mice; D008810:Mice, Inbred C57BL
D004317:Doxorubicin