Empedopeptin (BMY-28117), a new depsipeptide antibiotic. I. Production, isolation and properties.
Empedopeptin is a new antibiotic produced by empedobacter haloabium nov. sp. (ATCC 31962). It is a water-soluble depsipeptide antibiotic containing eight amino acid residues and a C14-fatty acid moiety in the molecule. Although structurally unrelated, empedopeptin and vancomycin have similar antimicrobial spectra against aerobic and anaerobic Gram-positive bacteria including antibiotic-resistant strains. Empedopeptin is highly active in vivo in mice against systemic infections of Staphylococcus aureus, Streptococcus pyogenes and Clostridium perfringens. Empedopeptin is not absorbed orally.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D005417:Flavobacterium / Q000145:classification / Q000378:metabolism*; D051379:Mice; D008826:Microbial Sensitivity Tests; D009842:Oligopeptides / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D009842:Oligopeptides; C043469:empedopeptin