Effect of a muscle relaxant, chlorphenesin carbamate, on the spinal neurons of rats.
The effects of chlorphenesin carbamate (CPC) and mephenesin on spinal neurons were investigated in spinal rats. CPC (50 mg/kg i.v.) inhibited the mono-(MSR) and poly-synaptic reflex (PSR), the latter being more susceptible than the former to CPC depression. Mephenesin also inhibited MSR and PSR, though the effects were short in duration. CPC had no effect on the dorsal root potential evoked by the stimulation of the dorsal root, while mephenesin reduced the dorsal root-dorsal root reflex. The excitability of motoneuron was reduced by the administration of CPC or mephenesin. The excitability of primary afferent terminal was unchanged by CPC, while it was inhibited by mephenesin. Neither CPC nor mephenesin influenced the field potential evoked by the dorsal root stimulation. Both CPC and mephenesin had no effect on the synaptic recovery. These results suggest that both CPC and mephenesin inhibit the firing of motoneurons by stabilizing the neuronal membrane, while mephenesin additionally suppresses the dorsal root reflex and the excitability of the primary afferent terminal. These inhibitory actions of CPC on spinal activities may contribute, at least partly, to its muscle relaxing action.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002743:Chlorphenesin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008615:Mephenesin / Q000494:pharmacology; D009046:Motor Neurons / Q000187:drug effects*; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D009475:Neurons, Afferent / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology
D009125:Muscle Relaxants, Central; C015071:chlorphenesin carbamate; D008615:Mephenesin; D002743:Chlorphenesin