title: Intestine-like remodeling of adult mouse glandular stomach by implanting of fetal intestinal mesenchyme.
abstract: A morphogenetic response of adult glandular stomach grown in contact with implanted fetal intestinal mesenchyme has been demonstrated. Mesenchymal tissues from intestines of 14- to 16-day-old BALB/c mouse fetuses were introduced beneath the epithelial layer of glandular stomach in 2-month-old mice and allowed to develop. Three to 4 weeks later, remodeling of the epithelial architecture had occurred; the characteristic glandular pit structure of normal stomach had been replaced by immature villi and crypts composed of mucus-secreting columnar cells more characteristic of intestinal tissues. Chief and parietal cells had disappeared, but neither goblet nor Paneth cells were observed. Such intestine-like morphogenesis was not induced by similarly implanted mesenchymal controls from fetal glandular stomach, forestomach, and salivary gland. A possible role of the mesenchymal stroma in the pathogenesis of intestinal metaplasia in stomach is discussed.
mesh_terms: D000375:Aging; D000818:Animals; D005260:Female; D007421:Intestine, Small / Q000166:cytology / Q000196:embryology* / Q000637:transplantation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009024:Morphogenesis; D011247:Pregnancy; D013270:Stomach / Q000166:cytology / Q000254:growth & development*; D014185:Transplantation, Isogeneic