Bronchospastic responses to aerosolized metabisulfite in asthmatic subjects: potential mechanisms and clinical implications.
Eight asthmatic patients with a history suggestive of sulfite sensitivity were studied, six of whom had a positive oral challenge to doses from 10 mg to 50 mg. All eight patients had aerosol metabisulfite challenge; six positive tests were observed at doses of 0.5 mg/ml and 5.0 mg/ml. Aerosolizing solutions of metabisulfite at 5.0 mg/ml generated significant amounts of free sulfur dioxide. Implications of these findings are discussed.
D000284:Administration, Oral; D000328:Adult; D000336:Aerosols; D001249:Asthma / Q000276:immunology*; D001986:Bronchial Spasm / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008297:Male; D012882:Skin Tests; D013447:Sulfites / Q000008:administration & dosage / Q000009:adverse effects*
D000336:Aerosols; D013447:Sulfites; C005199:potassium metabisulfite