Cortical mechanisms underlying acquisition of latch-box problems in the white rat.
Adult rats, previously subjected to bilateral frontal, parietal, occipital, frontocingulate or posterior cingulate ablations, were required to learn two discrete latch-box tasks (sliding a barrel-bolt to the right and elevating a hook). Those groups showing significant learning impairments had lesions to either the frontal cortex or frontocingulate cortex. The data suggest that the neocortical focus for latch-box deficits lies rostral to Level 8 on the Lashley brain diagram, while the frontocingulate focus for latch-box deficits lies within the prelimbic area.
D000818:Animals; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology*; D005625:Frontal Lobe / Q000502:physiology; D006179:Gyrus Cinguli / Q000502:physiology; D007858:Learning / Q000502:physiology*; D008297:Male; D009048:Motor Skills / Q000502:physiology*; D009778:Occipital Lobe / Q000502:physiology; D010296:Parietal Lobe / Q000502:physiology; D051381:Rats