title: Measurement of maprotiline and oxaprotiline in plasma by high-performance liquid chromatography of fluorescent derivatives.
abstract: The antidepressant maprotiline and its hydroxylated analogue oxaprotiline were assayed in plasma by solvent extraction and formation of fluorescent derivatives, which were purified by thin-layer chromatography and quantitated by high-performance liquid chromatography with fluorescence monitoring. The procedure possesses a high sensitivity, accuracy and reproducibility, and metabolites of the drugs did not interfere.
mesh_terms: D000873:Anthracenes / Q000097:blood*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002855:Chromatography, Thin Layer / Q000379:methods; D003619:Dansyl Compounds; D006801:Humans; D008376:Maprotiline / Q000031:analogs & derivatives / Q000097:blood*; D013050:Spectrometry, Fluorescence / Q000379:methods
chemical_list: D000873:Anthracenes; D003619:Dansyl Compounds; D008376:Maprotiline; C027299:hydroxymaprotilin; C029038:dansyl chloride