title: The activity of pars compacta neurons of the monkey substantia nigra is depressed by apomorphine.
abstract: In the substantia nigra of anesthetized and awake monkeys, presumptive dopamine cells of the pars compacta were electrophysiologically discriminated against non-dopaminergic cells of the pars reticulata by their lower discharge rate (0.5-8 vs 20-130 imp./s), their longer impulse duration (means 2.05 vs 0.92 ms), and their exclusive depression following systemic injection of the dopamine agonist apomorphine (24 out of 30 compacta neurons at 0.05-0.1 mg/kg s.c.).
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001931:Brain Mapping; D003864:Depression, Chemical; D004298:Dopamine / Q000502:physiology*; D008252:Macaca fascicularis; D009043:Motor Activity / Q000502:physiology; D013378:Substantia Nigra / Q000187:drug effects / Q000502:physiology*
chemical_list: D001058:Apomorphine; D004298:Dopamine