title: Rapid modulation of platelet aggregation in plasma by oxygenated sterols.
abstract: The effect of oxygenated sterols on platelet aggregation induced by thrombin and ADP has been studied. All oxygenated sterols tested with a hydroxyl group on the side chain enhanced thrombin-induced aggregation at 25 microM. In the case of ADP-induced aggregation, however, only 22S-hydroxycholesterol[(22S)-5-cholestene-3 beta,22-diol] enhanced the aggregation, and 22R-hydroxycholesterol[(22R)-5-cholestene-3 beta,22-diol], 24S-hydroxycholesterol[(24S)-5-cholestene-3 beta,24-diol], and 25-hydroxycholesterol[5-cholestene-3 beta,25-diol] inhibited it. These effects were observed within 10 min after the addition of oxygenated sterols to platelet suspensions in plasma.
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D002417:Cattle; D002784:Cholesterol / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D006888:Hydroxycholesterols / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects*; D013261:Sterols / Q000494:pharmacology*; D013917:Thrombin / Q000494:pharmacology; D013997:Time Factors
chemical_list: D006888:Hydroxycholesterols; D013261:Sterols; D000431:Ethanol; D000244:Adenosine Diphosphate; D002784:Cholesterol; D013917:Thrombin