[Mechanism of the clinical effects of UV-irradiated blood: the stimulation of DNA synthetic activity of human cells in culture].
Supernatants of UV-irradiated specimens of donor whole blood, leukocyte-platelet or red cell suspensions added to human embryonic cells in vitro produce a 1.4-1.6-fold increase in 3H-thymidine incorporation into human embryonic cells. Irradiation of blood plasma without the cells by the same doses as therapeutic ones is not followed by the effect indicated. Therefore the stimulation of the growth capacity of the blood after irradiation is connected with its cells. It is suggested that the effect under discussion is derived from the release of some active components from the blood cell surface (outer perimembranous layer) because of its photochemical destruction during UV-irradiation.
D001769:Blood / Q000378:metabolism / Q000528:radiation effects*; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis / Q000528:radiation effects*; D004622:Embryo, Mammalian / Q000166:cytology; D004912:Erythrocytes / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D010949:Plasma / Q000528:radiation effects; D013936:Thymidine / Q000097:blood; D014466:Ultraviolet Rays
D004247:DNA; D013936:Thymidine
Mekhanizm klinicheskikh éffektov UF-obluchennoĭ krovi: stimuliatsiia DNK-sinteticheskoĭ aktivnosti kletok cheloveka v kul'ture.