title: Reduction of the lethality and the nephrocalcinotic effect of single fluoride doses by magnesium in rats.
abstract: Magnesium chloride, administered by gavage to fasting young rats, 30 min prior to sodium fluoride, elevated the LD50 for fluoride from 76 to 104 mg/kg body wt. The LD50 was elevated to greater than 180 mg/kg when magnesium was given in a dose equivalent to 2 or 3 times that of fluoride. In two experiments, a dose of 50 mg F/kg caused a mean 14- and 19-fold increase above the level of the control animals in the renal calcium content. The nephrocalcinotic effect of fluoride was nearly completely prevented by administering magnesium in a dose which is 3-fold the equivalent of the fluoride dose 30 min prior to fluoride.
mesh_terms: D000818:Animals; D000931:Antidotes; D002114:Calcinosis / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D004573:Electrolytes / Q000378:metabolism; D005260:Female; D005458:Fluoride Poisoning / Q000517:prevention & control*; D007674:Kidney Diseases / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D007928:Lethal Dose 50; D008274:Magnesium / Q000627:therapeutic use*; D008297:Male; D011188:Potassium / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000931:Antidotes; D004573:Electrolytes; D008274:Magnesium; D011188:Potassium