title: [Midazolam as an induction agent for surgery of the anterior segment of the eye].
abstract: A new water-soluble benzodiazepine, midazolam maleate, was used at a dosage of 0.15 mg X kg-1 to induce general anaesthesia for eye surgery in 30 patients. The following parameters were measured at times C (control), t1, t2 and t3 (2, 5 and 10 min after induction): systemic arterial blood pressure, heart rate, respiratory rate, arterial blood gases and eye tone. Results showed very significant changes in acid-base balance, with an increase in PaCO2 and a significant fall in eye tone; changes in haemodynamic parameters were not significant. Midazolam therefore appeared to be a good drug to use for inducing anaesthesia in eye surgery, particularly in the elderly.
mesh_terms: D000368:Aged; D000768:Anesthesia, General / Q000379:methods*; D000777:Anesthetics; D000869:Anterior Eye Segment / Q000601:surgery*; D001569:Benzodiazepines / Q000008:administration & dosage / Q000494:pharmacology*; D001784:Blood Gas Analysis; D005128:Eye Diseases / Q000601:surgery; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008874:Midazolam; D008875:Middle Aged; D012119:Respiration / Q000187:drug effects
chemical_list: D000777:Anesthetics; D001569:Benzodiazepines; D008874:Midazolam
vernacular_title: Le midazolam comme agent d'induction pour la chirurgie du segment antérieur de l'oeil.