Pathology of vaginal atresia in BALB/cA-nu/+ and BALB/cA-nu/nu mice.
Vaginal atresia was observed with 5.8% morbidity (58/998 females) in adult BALB/cA-nu/+ and -nu/nu mice. Twenty-seven of the diseased mice were pathologically examined. In the affected mice, the vaginal orifice failed to open even 2 months of age and the perineal region was swollen, being scrotum-like. In addition, an increase of the follicle and a decrease of the corpus luteum were noticed in the ovary. This disorder was regarded as a malformation concerned with a heredity.
D000818:Animals; D005260:Female; D051379:Mice; D008807:Mice, Inbred BALB C; D012376:Rodent Diseases / Q000151:congenital* / Q000473:pathology; D014621:Vagina / Q000002:abnormalities* / Q000473:pathology