title: The decarboxylation of 3-mercaptopyruvate to 2-mercaptoacetate.
abstract: Rat brain mitochondria were found to convert 3-mercaptopyruvate to 2-mercaptoacetate in the presence of NAD+, coenzyme A and thiamin pyrophosphate. The overall reaction probably consists of an oxidative decarboxylation of 3-mercaptopyruvate with 2-mercaptoacetyl CoA as a product which is then hydrolyzed to 2-mercaptoacetate by acyl CoA hydrolase.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D003065:Coenzyme A / Q000378:metabolism; D003545:Cysteine / Q000031:analogs & derivatives* / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D017830:Octoxynol; D011092:Polyethylene Glycols; D051381:Rats; D013835:Thiamine Pyrophosphate / Q000378:metabolism; D013864:Thioglycolates / Q000378:metabolism*
chemical_list: D013864:Thioglycolates; D009243:NAD; D011092:Polyethylene Glycols; C008366:3-mercaptopyruvic acid; C017487:2-mercaptoacetate; D017830:Octoxynol; D003545:Cysteine; D013835:Thiamine Pyrophosphate; D003065:Coenzyme A