Synthesis of Methyl 2,3-bis(hydroxymethyl)-5-phenyl-7-oxabicyclo[2.2.1]hepta-2,5-diene- 6-carboxylate bis(N-methylcarbamate) derivatives as potential antitumor agents.
Methyl 2,3-bis(hydroxymethyl)-5-phenyl-7-oxabicyclo[2.2.1]hepta-2,5- diene-6-carboxylate bis(N-methylcarbamate) along with the p-chlorophenyl and p-nitrophenyl analogues were synthesized using a Diels Alder reaction. The title compound and the p-chlorophenyl analogue were inactive against murine P388 lymphocytic leukemia.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis*; D002219:Carbamates / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice
D000970:Antineoplastic Agents; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D002219:Carbamates