Is cutaneous apoprotein B a better discriminator than serum lipoproteins for atherosclerosis?
Serum lipids, skin apoprotein B (apo B) and skin cholesterol measurements have been investigated in 2 populations: one with normal coronarography, the other with pathological coronarography. Within these 2 populations there were highly significant differences in serum apo B (P less than 0.001), skin cholesterol (P less than 0.01) and skin apo B (P less than 0.001) levels. Skin apo B is a valuable test because its increase is closely related to the coronary heart disease. From these 2 populations, 2 groups with normal serum apo B (less than 1.3 g/l) were selected and compared. No significant differences in the various serum lipids were observed except for triglycerides (P less than 0.05) and serum apo B (P less than 0.05). However, a very significant difference was noticed in the skin apo B (P less than 0.001). With this cutaneous apo B determination it was possible to foresee coronary heart disease in 75% of patients. This test can be therefore considered useful to predict coronary status.
D001055:Apolipoproteins B / Q000032:analysis* / Q000097:blood; D001161:Arteriosclerosis / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism; D002784:Cholesterol / Q000032:analysis; D017023:Coronary Angiography; D003327:Coronary Disease / Q000097:blood / Q000175:diagnosis / Q000378:metabolism; D003331:Coronary Vessels / Q000473:pathology*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000032:analysis*
D001055:Apolipoproteins B; D008055:Lipids; D002784:Cholesterol