title: [Effect of various doses of aspirin after a single and long-term administration on platelet aggregation in patients with ischemic heart disease].
abstract: A study of 169 patients with coronary heart disease has shown that the duration and intensity of the inhibition of platelet aggregation following the single administration of 0.5, 1 and 1.5 g of aspirin is largely determined by the dose used. It has been established that in individuals sensitive to aspirin, the intake of 0.5 g of the drug causes a marked inhibition of platelet aggregation lasting for over 24 hours. A year-long follow-up of patients with myocardial infarction receiving 0.5 g of aspirin daily has demonstrated that platelet aggregation is consistently depressed throughout the entire period of observation.
mesh_terms: D000328:Adult; D000368:Aged; D000925:Anticoagulants; D001241:Aspirin / Q000008:administration & dosage*; D003327:Coronary Disease / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000517:prevention & control*; D010974:Platelet Aggregation / Q000187:drug effects*; D013997:Time Factors
chemical_list: D000925:Anticoagulants; D001241:Aspirin
vernacular_title: Vliianie razlichnykh doz aspirina pri odnokratnom i dlitel'nom ego primenenii na agregatsiiu trombotsitov u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.