Adenosine deaminase antagonizes inhibitory responses to adenosine and non-adrenergic, non-cholinergic inhibitory nerve stimulation in isolated preparations of guinea-pig trachea.
In guinea-pig isolated tracheal tube preparations treated with dipyridamole, adenosine deaminase antagonized inhibitory responses to adenosine and non-adrenergic, non-cholinergic nerve stimulation. Inhibitory responses to vasoactive intestinal peptide (VIP) were unaffected and hyoscine-sensitive excitatory responses to field stimulation were not reduced. The evidence supports a role of adenosine as an inhibitory neurotransmitter in non-adrenergic, non-cholinergic nerves in trachea.
D000241:Adenosine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000243:Adenosine Deaminase / Q000494:pharmacology*; D000818:Animals; D004176:Dipyridamole / Q000494:pharmacology; D004558:Electric Stimulation; D005260:Female; D006145:Guanethidine / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D009474:Neurons / Q000187:drug effects*; D009700:Nucleoside Deaminases / Q000494:pharmacology*; D012601:Scopolamine / Q000494:pharmacology; D014132:Trachea / Q000294:innervation
D004176:Dipyridamole; D012601:Scopolamine; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase; D000241:Adenosine; D006145:Guanethidine