A novel biologically active seleno-organic compound--I. Glutathione peroxidase-like activity in vitro and antioxidant capacity of PZ 51 (Ebselen).
a synthetic seleno-organic compound, 2-phenyl-1,2-benzoisoselenazol-3(2H)-one (PZ 51), exhibits GSH peroxidase-like activity in vitro, in contrast to its sulfur analog, PZ 25. In addition, PZ 51 behaves as an antioxidant shown by a temporary protection of rat liver microsomes against ascorbate/ADP-Fe-induced lipid peroxidation, an effect also elicited by PZ 25 but to a smaller extent. This protection against lipid peroxidation is independent of GSH and of P-450 monooxygenase activity.
D000818:Animals; D000975:Antioxidants; D001393:Azoles / Q000494:pharmacology*; D005979:Glutathione Peroxidase / Q000378:metabolism*; D066298:In Vitro Techniques; D054833:Isoindoles; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D016566:Organoselenium Compounds; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium
D000975:Antioxidants; D001393:Azoles; D054833:Isoindoles; D008054:Lipid Peroxides; D016566:Organoselenium Compounds; C042986:ebselen; D005979:Glutathione Peroxidase; D012643:Selenium