A case of agammaglobulinaemia complicated by meningoencephalitis due to Echo virus 27.
A boy with agammaglobulinaemia diagnosed and treated from the age of 3 years 2 months developed encephalitis at 4 years 3 months. The illness showed a remitting but deteriorating course until death aged 6 years 5 months. Echo virus type 27 was isolated from the cerebrospinal fluid during the terminal illness. The virus was not isolated from five earlier cerebrospinal fluid samples nor was virus detected in a temporal lobe biopsy.
D000361:Agammaglobulinemia / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D004457:Echovirus Infections / Q000134:cerebrospinal fluid / Q000150:complications*; D029822:Enterovirus B, Human / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid / Q000150:complications*