Effect of piroxicam on primary intestinal tumors induced in rats by N-methylnitrosourea.
Piroxicam, a non-steroidal anti-inflammatory agent, was administered in the feed to rats which had been inoculated intra-rectally with N-methylnitrosourea (MNU). When examined 5 months later, the piroxicam-treated rats had a significant reduction of intestinal tumors compared to tumor incidences and tumor numbers in rats which were fed drug-free diet. There was no evidence of toxicity associated with the consumption of piroxicam.
D000818:Animals; D001835:Body Weight; D004032:Diet; D007414:Intestinal Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D008770:Methylnitrosourea; D010894:Piroxicam; D051381:Rats; D011919:Rats, Inbred Strains; D013843:Thiazines / Q000627:therapeutic use*
D013843:Thiazines; D010894:Piroxicam; D008770:Methylnitrosourea