Chlordiazepoxide injection elevates the NaCl solution acceptance-rejection function.
Injection (SC) of chlordiazepoxide (2-8 mg/kg) increased the intake of NaCl solution (0.5-3.0% NaCl) as well as water in water-deprived rats when these fluids were made available singly during daily 1-hr rehydration periods. The marked enhancement of this drug effect when NaCl solution was the available fluid does not appear to be due to the induction of a sodium appetite or the mimicking of an increase in water deprivation. The exaggeration of the drug effect when an NaCl solution is the drinking fluid, as opposed to water, may be useful as a sensitive index of action for punishment-attenuating (anxiolytic) drugs.
D000704:Analysis of Variance; D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004326:Drinking / Q000187:drug effects; D005518:Food Preferences / Q000187:drug effects*; D008297:Male; D011678:Punishment; D051381:Rats; D012965:Sodium Chloride / Q000008:administration & dosage*
D012965:Sodium Chloride; D002707:Chlordiazepoxide