title: Replacement of the anterior cruciate ligament by an allogeneic tendon graft. An experimental study in the dog.
abstract: The revascularisation and remodelling of allografts used to replace the anterior cruciate ligament in the canine knee were studied by microangiographic, histological and biomechanical methods. The 26 allografts were obtained from the patellar tendons of other dogs and were stored by deep freezing. In a control study a strip of patellar tendon from the same leg was used as an autologous free graft. Microangiography showed that the allografts had been revascularised from the sixth postoperative week, and had later developed an intrinsic vascular pattern similar to that of a normal anterior cruciate ligament. Histologically, the allograft regained a fibrous framework similar to that of a normal ligament, and showed no evidence of immunological rejection. Biomechanical tests on the allograft replacements showed that their mean maximum tensile strength at 30 weeks was about 30% of that of the control ligaments. There were no significant differences between the mechanical properties of the allografts and the autografts.
mesh_terms: D000792:Angiography / Q000379:methods; D000818:Animals; D001696:Biomechanical Phenomena; D004285:Dogs; D007717:Knee; D007719:Knee Joint / Q000033:anatomy & histology / Q000098:blood supply / Q000601:surgery*; D008023:Ligaments, Articular / Q000033:anatomy & histology / Q000098:blood supply / Q000601:surgery*; D013583:Synovial Membrane / Q000098:blood supply; D013710:Tendons / Q000033:anatomy & histology / Q000098:blood supply / Q000637:transplantation*; D013997:Time Factors; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous