Vasoconstrictor and the anti-inflammatory effects of 7 corticosteroids.
The vasoconstrictor effect of 7 proprietary corticosteroid creams was compared with their effect on patches of allergic contact dermatitis provoked by patch testing in 20 subjects. A parallel between the blanching effect on the normal skin and the anti-inflammatory effect on the eczematous skin was generally found. A modified patch test method using the Finn chamber technique is described, which (with certain restrictions) offers an opportunity of studying the anti-inflammatory effect of corticosteroids on allergic dermatitis under standard conditions.
D000208:Acute Disease; D000305:Adrenal Cortex Hormones / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D001623:Betamethasone / Q000031:analogs & derivatives / Q000627:therapeutic use; D001624:Betamethasone Valerate / Q000627:therapeutic use; D002990:Clobetasol / Q000031:analogs & derivatives / Q000627:therapeutic use; D003877:Dermatitis, Contact / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000031:analogs & derivatives / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D012867:Skin / Q000098:blood supply*; D014222:Triamcinolone Acetonide / Q000627:therapeutic use; D014661:Vasoconstriction / Q000187:drug effects*
D000305:Adrenal Cortex Hormones; C007975:hydrocortisone-17-butyrate; C021650:hydrocortisone acetate; C011175:betamethasone-17,21-dipropionate; C010893:clobetasone butyrate; D001623:Betamethasone; D001624:Betamethasone Valerate; D002990:Clobetasol; D014222:Triamcinolone Acetonide; D006854:Hydrocortisone