title: Treatment of shock in a canine model of pulmonary embolism.
abstract: Despite the high mortality (greater than 30%) associated with hypotension complicating pulmonary embolism, previous studies have not systematically investigated how best to treat shock resulting from pulmonary embolism. In 24 dogs, we measured relevant hemodynamic parameters before and after shock was produced by intravenously injected autologous blood clots. When systemic blood pressure fell to 70 mmHg, dogs were randomly divided into groups and treated blindly for 1 h. All control dogs and all dogs treated with volume and isoproterenol died. In contrast, all dogs treated with noradrenaline were resuscitated and remained hemodynamically stable for 1 h. This effect of noradrenaline was significant (p less than 0.01, Fisher's exact test). Noradrenaline improved right ventricular performance by increasing blood pressure and improving right ventricular perfusion and/or by a direct increase in contractility. We conclude that in a canine model of pulmonary embolism and shock, noradrenaline may be the drug of choice for acute resuscitation.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D007545:Isoproterenol / Q000627:therapeutic use*; D009200:Myocardial Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000627:therapeutic use*; D010952:Plasma Substitutes / Q000627:therapeutic use*; D011655:Pulmonary Embolism / Q000150:complications*; D011897:Random Allocation; D012769:Shock / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D010952:Plasma Substitutes; D007545:Isoproterenol; D009638:Norepinephrine