[Evaluation of the toxicity of a chemical by adsorbed typhoid vaccine by a pharmacological test (hexenal sleep) and by a change in thymus weight in white mice].
With the wide spread of immunoprophylaxis, investigations aimed at introducing new methods for the control of vaccines are gaining in importance. As indicated by the results of investigations, the reactogenicity of vaccinal preparations for humans may be evaluated, to a certain extent, by the degree of the stress action produced by these preparations and the duration of hexenal narcosis in laboratory animals.
D000293:Adolescent; D000327:Adsorption; D000328:Adult; D000818:Animals; D006591:Hexobarbital / Q000494:pharmacology*; D006801:Humans; D007114:Immunization; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D012890:Sleep / Q000187:drug effects*; D013950:Thymus Gland / Q000187:drug effects*; D013997:Time Factors; D014436:Typhoid-Paratyphoid Vaccines / Q000009:adverse effects / Q000633:toxicity*
D014436:Typhoid-Paratyphoid Vaccines; D006591:Hexobarbital
Otsenka toksichnosti khimicheskoĭ sorbirovannoĭ briushnotifoznoĭ vaktsiny po farmakologicheskomu testu (geksenalovyĭ son) i izmeneniiu massy timusa belykh mysheĭ.