title: [Experimental study of lincomycin ointment and gel].
abstract: The pharmacokinetics and safety of the lincomycin ointment and gel were studied. It was shown that diffusion of lincomycin through the skin was satisfactory. Investigation of their general toxicity and organotropic properties revealed neither irritating effect nor changes in the internal organs associated with the toxic effect of the drugs. On the basis of the data on the stability of the lincomycin ointment and gel obtained on their storage the lincomycin ointment was recommended for industrial production.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D004058:Diffusion; D004355:Drug Stability; D005782:Gels; D006168:Guinea Pigs; D007700:Kinetics; D008034:Lincomycin / Q000008:administration & dosage* / Q000378:metabolism / Q000633:toxicity; D009824:Ointments; D011817:Rabbits; D012867:Skin / Q000187:drug effects; D012869:Skin Absorption / Q000187:drug effects; D013997:Time Factors
chemical_list: D005782:Gels; D009824:Ointments; D008034:Lincomycin
vernacular_title: Eksperimental'noe izuchenie mazi i gelia linkomitsina.