Regional blood flow during cardiopulmonary resuscitation in dogs.
We studied regional blood flow (QR) using radiolabeled microspheres in 12 anesthetized dogs during cardiopulmonary resuscitation (CPR). A circumferential vest and abdominal binder were used with a mechanical ventilator to deliver 30 simultaneous chest compressions and ventilations per minute. When this device was modified to increase aortic pressure (Pao) during compression and the aortic-to-right atrial pressure gradient (Pao-Pra) during relaxation, cerebral and myocardial QR increased significantly. These findings suggest that QR during CPR can be improved by augmenting perfusion-pressure gradients across the cerebral and coronary circulations.
D000818:Animals; D001921:Brain / Q000098:blood supply*; D003331:Coronary Vessels; D004285:Dogs; D005676:Gravity Suits; D006439:Hemodynamics; D007668:Kidney / Q000098:blood supply; D008168:Lung / Q000098:blood supply; D008863:Microspheres; D012039:Regional Blood Flow; D012121:Respiration, Artificial; D012151:Resuscitation / Q000379:methods*; D014693:Ventricular Fibrillation / Q000628:therapy*