title: Phospholipid composition of dystrophic chicken erythrocyte plasmalemmae. II. Characterization of a unique lipid from dystrophic erythrocyte membranes as ethanolamine plasmalogen.
abstract: The phospholipid content of normal (line 412) and dystrophic (line 413) chicken erythrocyte plasmalemmae has been quantified on a developmental basis using sex matched controls. A specific minor phospholipid component, ethanolamine plasmalogen, is identified from dystrophic erythrocyte membrane preparations. To arrive at this identification, data from studies utilizing gas-liquid chromatography, thin-layer chromatography, [14C]ethanolamine incorporation, and biochemical assay for specific organic moieties were correlated. This phospholipid has the potential to alter and regulate membrane fluidity and thus membrane function. The possible presence of significant concentrations of plasmalogen in human dystrophic tissues may serve as a marker for dystrophy and thus be of clinical importance.
mesh_terms: D000818:Animals; D002645:Chickens; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D004910:Erythrocyte Membrane / Q000378:metabolism*; D019856:Ethanolamine; D004983:Ethanolamines / Q000097:blood; D008563:Membrane Lipids / Q000097:blood*; D009137:Muscular Dystrophy, Animal / Q000097:blood*; D010659:Phenylhydrazines; D010955:Plasmalogens / Q000097:blood*
chemical_list: D004983:Ethanolamines; D008563:Membrane Lipids; D010659:Phenylhydrazines; D010955:Plasmalogens; C020791:phosphatidal ethanolamines; C004787:2,4-dinitrophenylhydrazine; D019856:Ethanolamine