Akinesia after locally applied morphine near the nucleus raphe pontis of the rat.
Morphine (10 micrograms/microliter) was injected into different sites within the pontine brainstem in different groups of rats with indwelling guide cannulae. The rats were tested for the persistence of abnormal postures as a measure for the degree of akinesia. Local morphine was most effective in inducing akinesia at a site identical or close to the nucleus raphe pontis. Midline injections were effective in contrast to bilateral injections. Fenfluramine, a serotonin releaser, strongly potentiated morphine akinesia.
D000818:Animals; D001931:Brain Mapping; D004357:Drug Synergism; D005277:Fenfluramine / Q000008:administration & dosage; D009020:Morphine / Q000008:administration & dosage / Q000633:toxicity*; D009069:Movement Disorders / Q000139:chemically induced*; D011149:Pons / Q000187:drug effects*; D011903:Raphe Nuclei / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology
D005277:Fenfluramine; D012701:Serotonin; D009020:Morphine