Regression of atherosclerotic lesions and control of plasma lipids and lipoprotein cholesterol by Anna Pavala Sindhooram therapy.
Plasma and lipoprotein distribution of cholesterol and triglycerides were measured in experimentally induced hypercholesterolemia associated with moderate hypothyroidism and after Anna Pavala Sindhooram (APSm) therapy in rat models. Feeding atherogenic diet increased all the three lipoprotein classes (HDL, LDL and VLDL). When APSm was administered for 90 days at a dose of 30 mg/rat/day, orally with and without atherogenic diet, it brought down the already raised levels of cholesterol and triglycerides in LDL and VLDL. Histological studies on the aorta revealed that APSm therapy produces regression of the atherosclerotic lesions.
D000818:Animals; D001011:Aorta / Q000473:pathology; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D001798:Blood Proteins / Q000378:metabolism; D002784:Cholesterol / Q000097:blood*; D004036:Diet, Atherogenic; D007455:Iodine / Q000097:blood; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008903:Minerals / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000097:blood
D001798:Blood Proteins; D008055:Lipids; D008074:Lipoproteins; D008903:Minerals; D010936:Plant Extracts; D014280:Triglycerides; C035984:Anna Pavala Sindhooram; D007455:Iodine; D002784:Cholesterol