[Glutathione and tissue uptake of triiodothyronine].
The effect of glutathione (GSH) on the 125I-Triiodothyronine uptake was studied in renal cortex slices. Addition of Diamide (30 mM), oxidizing reagent for GSH, to the incubation buffer decreases the hormonal uptake (-28%) while GSH (20mM) can reverse the effect of diamide. So the modification of T3 distribution previously shown in vitamin A-deficient rats can be attributed to the GSH deficiency already observed in these animals.
D000818:Animals; D003958:Diamide / Q000494:pharmacology; D005978:Glutathione / Q000502:physiology*; D066298:In Vitro Techniques; D007672:Kidney Cortex / Q000378:metabolism*; D008297:Male; D051381:Rats; D014284:Triiodothyronine / Q000378:metabolism*
D014284:Triiodothyronine; D003958:Diamide; D005978:Glutathione
Glutathion et captation tissulaire de la triiodothyronine.