A comparison of the postnatal development of post-activation potentiation in the neocortex and dentate gyrus of the rat.
The postnatal development of short-term potentiation (STP) and long-term potentiation (LTP) was examined in the neocortex and dentate gyrus of rats aged 7 days to adult. STP and LTP of the transcallosal response in the neocortex could not be demonstrated until the third postnatal week. STP and LTP of the perforant path-dentate response could not be demonstrated until the second postnatal week. In both cases, STP appeared several days before LTP. Structural and neurochemical correlates of STP/LTP development, and their implications for possible STP/LTP mechanisms, are discussed.
D000375:Aging; D000818:Animals; D002540:Cerebral Cortex / Q000254:growth & development* / Q000502:physiology; D004553:Electric Conductivity; D004558:Electric Stimulation; D005071:Evoked Potentials; D006624:Hippocampus / Q000254:growth & development* / Q000502:physiology; D008297:Male; D009929:Organ Size; D051381:Rats