Effect of alkaloids of Solanum melongena on the central nervous system.
Crude alkaloidal fraction isolated from the leaves of Solanum melongena was screened for its effects on the central nervous system. It exhibited significant analgesic effect and some CNS depression but no anticonvulsant action. The analgesic effects were of non-narcotic type. LD50 was estimated to be higher than 1 g/kg i.p. in mice.
D000661:Amphetamine / Q000633:toxicity; D000700:Analgesics; D000818:Animals; D000927:Anticonvulsants; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D002415:Cats; D002492:Central Nervous System Depressants; D007928:Lethal Dose 50; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009042:Motivation; D009043:Motor Activity / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats; D012890:Sleep / Q000187:drug effects; D012991:Solanaceous Alkaloids / Q000494:pharmacology* / Q000633:toxicity
D000700:Analgesics; D000927:Anticonvulsants; D002492:Central Nervous System Depressants; D012991:Solanaceous Alkaloids; D009020:Morphine; D000661:Amphetamine; D010424:Pentobarbital