Polymer resins with amino acid containing pendants for sorption of bilirubin. I. Comparison of Merrifield and polyamide resins.
Merrifield resins with various amino acid containing pendants and a water swellable polyamide resin with the peptide alanine-alanine-alanine-arginine as the pendant group have been prepared by solid phase peptide synthesis. Merrifield resins with either arginine or lysine pendants are capable of sorbing bilirubin from aqueous solution (pH = 7.8) but those with other amino acid pendants gave no indication of sorption. The polyamide-arginine resin showed, on a functional group basis, a higher capacity for bilirubin than does cholestyramine. It is proposed that the formation of salt linkages causes a strong interaction of bilirubin with arginine and lysine.
D000327:Adsorption; D000596:Amino Acids; D001120:Arginine; D001663:Bilirubin; D009757:Nylons / Q000138:chemical synthesis; D009842:Oligopeptides; D011137:Polystyrenes / Q000138:chemical synthesis; D011145:Polyvinyls / Q000138:chemical synthesis; D012116:Resins, Plant / Q000138:chemical synthesis
D000596:Amino Acids; D009757:Nylons; D009842:Oligopeptides; D011137:Polystyrenes; D011145:Polyvinyls; D012116:Resins, Plant; D001120:Arginine; D001663:Bilirubin