Effect of charcoal hemoperfusion on amino acid disturbance in experimental hepatic coma.
Using the galactosamine induced hepatic coma rat model, we studied the effects of coated charcoal hemoperfusion on amino acids in plasma and CSF in grade III hepatic coma. We found that 1 hour of hemoperfusion significantly reduced AAAs and BCAAs in plasma and increased the molar ratio of BCAA:AAA. When rats in grade III coma were treated with 2 consecutive 1-hour hemoperfusions, the substantial reduction of plasma AAAs resulted in a significant decrease of AAA levels in CSF.
D000327:Adsorption; D000596:Amino Acids / Q000378:metabolism*; D000597:Amino Acids, Branched-Chain / Q000378:metabolism; D000818:Animals; D002606:Charcoal; D002851:Chromatography, High Pressure Liquid; D004195:Disease Models, Animal; D005688:Galactosamine; D006464:Hemoperfusion; D006501:Hepatic Encephalopathy / Q000139:chemically induced / Q000378:metabolism* / Q000628:therapy; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D002606:Charcoal; D005688:Galactosamine