Human leukemia K562 cells: relationship between hemin-mediated erythroid induction, cell proliferation and expression of c-abl and c-myc oncogenes.
We have studied the expression of the c-myc and c-abl oncogenes in two human leukemic K562 cell lines which do express hemoglobin genes retaining a differential rate of cell proliferation. Our data indicate that in hemin-induced K562(S) cells the expression of c-abl oncogene decreases and appears to be related to a decrease in the proliferation capacity rather than to the activation of differentiated functions. The K562(hC) cell line, which produces large amounts of Hb Gower 1 retaining an efficient rate of cell proliferation, expresses indeed the c-abl oncogene at high level.
D002455:Cell Division; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D004912:Erythrocytes / Q000166:cytology*; D005786:Gene Expression Regulation; D006418:Heme / Q000031:analogs & derivatives*; D006427:Hemin / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007938:Leukemia / Q000235:genetics*; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D012333:RNA, Messenger / Q000378:metabolism
D006454:Hemoglobins; D012333:RNA, Messenger; D006418:Heme; D006427:Hemin