Lack of a pharmacokinetic interaction between nifedipine and the beta-adrenoceptor blockers metoprolol and atenolol.
Nifedipine, metoprolol and atenolol were administered orally to young, healthy volunteers. Each drug was given alone and nifedipine was also given with both beta-adrenoceptor blockers. Each drug was given for 3 days immediately before the study days. Plasma and urine drug concentrations were measured and the relevant pharmacokinetic parameters calculated. No pharmacokinetic interaction between nifedipine and the beta-adrenoceptor blockers was revealed.
D000328:Adult; D001262:Atenolol / Q000097:blood / Q000378:metabolism*; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008790:Metoprolol / Q000097:blood / Q000378:metabolism*; D009543:Nifedipine / Q000097:blood / Q000378:metabolism*
D001262:Atenolol; D008790:Metoprolol; D009543:Nifedipine