Development of a standardized analysis strategy for basic drugs, using ion-pair extraction and high-performance liquid chromatography. VI. Drug level determination in saliva.
Assay methods for measuring saliva levels of carbamazepine and its active metabolite, and of amidopyrine are developed using a standardized analysis strategy. Both assay methods include ion-pair extraction of the analytes with octylsulphate as the counter-ion and chromatography on a CN-bonded phase using a hexane--dichloromethane--acetonitrile--propylamine mixture as the mobile phase. Both methods are applied to patient samples.
D000632:Aminopyrine / Q000032:analysis* / Q000097:blood; D002220:Carbamazepine / Q000031:analogs & derivatives / Q000032:analysis* / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D012463:Saliva / Q000032:analysis*
D000632:Aminopyrine; D002220:Carbamazepine; C012227:carbamazepine epoxide