Mutation frequency in human lymphocytes increases with age.
Several theories of ageing predict that somatic mutations should increase with age. This prediction was tested for human lymphocytes using a recently developed clonal technique for enumeration of mutations, and an increase of 1.6% per year in mutations with age was detected.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D002999:Clone Cells; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008214:Lymphocytes / Q000166:cytology*; D008875:Middle Aged; D009154:Mutation