Vitamin K-dependent carboxylation: inhibition by a peptide containing 4-methylene glutamic acid.
The peptide Boc-4-methylene Glu-Glu-Val has been synthesized and shown to be a strong inhibitor of the vitamin K-dependent carboxylation catalyzed by a detergent solubilized rat liver microsome preparation. The inhibition is apparently competitive with respect to the substrate peptide and non-competitive with respect to HCO3-.
D000818:Animals; D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D005971:Glutamates; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D008862:Microsomes, Liver / Q000378:metabolism*; D009842:Oligopeptides / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D014813:Vitamin K Deficiency / Q000378:metabolism*
D005971:Glutamates; D009842:Oligopeptides; C030977:4-methyleneglutamic acid; C043395:butyloxycarbonyl-4-methylene-glutamyl-glutamyl-valine; D002265:Carboxylic Ester Hydrolases