Activated expression of the N-myc gene in human neuroblastomas and related tumors.
In neuroblastoma lines in which the N-myc gene is present as a single copy, the expression of N-myc as messenger RNA is increased relative to that in nonneuroblastoma cell lines and tumors. The increase of expression in neuroblastomas with amplified N-myc genes is the result of (i) an increase in the absolute amount of expression of each N-myc gene and (ii) an increase in the copy number of the N-myc gene. A second gene--which is amplified in many of the same lines as N-myc--is expressed to about the same degree in most human cell lines and primary tumors regardless of origin (when normalized to gene copy number). Thus, a change in the regulation of N-myc expression in neuroblastomas and certain other tumors results in greatly increased expression of each N-myc gene copy.
D002460:Cell Line; D005784:Gene Amplification; D005786:Gene Expression Regulation; D006801:Humans; D009447:Neuroblastoma / Q000235:genetics*; D009857:Oncogenes; D012333:RNA, Messenger / Q000378:metabolism
D012333:RNA, Messenger