title: The genetic analysis of quantitative trait differences between two homozygous lines.
abstract: Previous maximum likelihood methods to analyze quantitative data on two inbred parental strains, their F1 and backcross generations are extended in three directions: (1) a method is suggested to transform the data to better satisfy the assumptions of normality and homoscedasticity; (2) the likelihoods are modified to allow for litter correlations and heteroscedasticity and (3) allowance is made for the incorporation of F2 data. The problem of making a choice among a set of simple genetic hypotheses is further discussed.
mesh_terms: D003433:Crosses, Genetic; D014644:Genetic Variation; D006720:Homozygote; D007178:Inbreeding; D008957:Models, Genetic; D010641:Phenotype; D011336:Probability