[Learning behavior in rats after chronic haloperidol treatment].
The effect of 3 week chronic haloperidol treatment has been investigated in rats by retention of active avoidance (pole jumping). In the period of dopaminergic supersensitivity, i.e. after withdrawal of haloperidol, pretreated rats showed a better retention of the learned reaction than controls. The results demonstrate that the neuroleptic-induced supersensitivity enhanced not only the spontaneous and stimulated locomotor activity, but also improved the retention of an active avoidance reaction.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D006220:Haloperidol / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D006220:Haloperidol
Lernverhalten von Ratten nach chronischer Haloperidolvorbehandlung.