[Microvascular changes in the lungs of rats with bronchiolo-alveolar fibrosis caused by the intrabronchial administration of trypsin].
Rats were injected intrabronchially with trypsin solution. During the first 3 days, the animals developed acute desquamative alveolitis and at the second week bronchioloalveolar fibrosis. As for the capillaries of the alveolar walls, some of the capillary loops manifested obliteration, whereas other ones ectasia to the alveolar lumen. Deposition of immunoglobulins in the walls of pulmonary vessels was not revealed.
D000818:Animals; D001980:Bronchi; D005260:Female; D008168:Lung / Q000098:blood supply* / Q000187:drug effects; D008297:Male; D008833:Microcirculation / Q000187:drug effects / Q000648:ultrastructure; D008854:Microscopy, Electron; D011650:Pulmonary Alveoli / Q000187:drug effects / Q000648:ultrastructure; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000473:pathology*; D051381:Rats; D013997:Time Factors; D014357:Trypsin / Q000494:pharmacology*
D014357:Trypsin
Izmeneniia mikrososudov legkikh krys pri bronkhiolo-al'veoliarnom fibroze, vyzvannom vnutribronkhial'nym vvedeniem tripsina.