[Participation of the kidneys in the reaction of the anticoagulation system to thrombin administered into the blood stream].
Thrombin injection into white rats jugular vein in dose 20 units on 200 g of body mass results in more considerable release of plasminogen activator in blood of renal vein as compared with blood of cava inferior and jugular veins. In this case the fibrinolytic activity of kidney cortical part decreases, but in medullar part it does not alter. The decrease of antiplasmin content in blood of renal vein is due to alpha 2-macroglobulins, in blood of jugular and cava inferior veins--to alpha 1-antithrypsin.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D005342:Fibrinolysis / Q000187:drug effects*; D007601:Jugular Veins / Q000502:physiology; D007668:Kidney / Q000502:physiology*; D051381:Rats; D012082:Renal Veins / Q000502:physiology; D012769:Shock / Q000139:chemically induced / Q000503:physiopathology; D013917:Thrombin / Q000494:pharmacology*; D014682:Vena Cava, Inferior / Q000502:physiology
D013917:Thrombin
Uchastie pochek v osushchestvlenii reaktsii protivosvertyvaiushcheĭ sistemy na vvedenie v krovotok trombina.