Modelling of drug release kinetics from a laminated device having an erodible drug reservoir.
The purpose of this communication is to present a preliminary analysis to demonstrate the effect of laminating a drug-containing erodible polymer matrix with a second barrier membrane. A mathematical model for the diffusive release of the drug from an erodible polymer device undergoing surface erosion has been extended to similar devices with a secondary membrane to allow a comparison of the results. The results indicate that the constant rate of release characteristic of erodible devices is not sacrificed with the addition of the secondary membrane; moreover, the membrane provides additional controllable parameters at the disposal of the device designer.
D003692:Delayed-Action Preparations; D007700:Kinetics; D008962:Models, Theoretical; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011108:Polymers
D003692:Delayed-Action Preparations; D004364:Pharmaceutical Preparations; D011108:Polymers