Intracellular mechanism of quinidine action on muscle contraction. A comparison between rabbit cardiac and skeletal muscle.
The mechanism of quinidine action on rabbit cardiac and skeletal muscle was examined with "functionally skinned" muscle-fiber preparations. By using these preparations we could correlate measurements of muscle tension with the effect of quinidine on the Ca2+ activation of the contractile proteins and on the Ca2+ uptake and release from the sarcoplasmic reticulum (SR).
D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009124:Muscle Proteins / Q000378:metabolism; D009132:Muscles / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects*; D011802:Quinidine / Q000494:pharmacology*; D011817:Rabbits
D009124:Muscle Proteins; D002110:Caffeine; D008274:Magnesium; D011802:Quinidine; D002118:Calcium