Radiation absorbed dose estimates at the cellular level for some electron-emitting radionuclides for radioimmunotherapy.
Calculation of the radiation dose at the cellular level is given for several radionuclides that appear promising for radioimmunotherapy using the radiation dose distribution from a point source. The radionuclides have half-lives in the 1-3 day range and have electron ranges up to several hundred micrometers. The investigation emphasizes the physical considerations in radionuclide choice for the radiolabeling of monoclonal antibodies or antibody fragments.
D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000912:Antibodies, Neoplasm / Q000276:immunology; D003131:Combined Modality Therapy; D004583:Electrons; D006801:Humans; D007128:Immunoglobulin Fragments / Q000276:immunology; D007167:Immunotherapy; D009369:Neoplasms / Q000532:radiotherapy / Q000628:therapy*; D011829:Radiation Dosage; D011868:Radioisotopes / Q000627:therapeutic use*
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D007128:Immunoglobulin Fragments; D011868:Radioisotopes