[Studies of the cellular immune response in patients with urinary bladder carcinoma. X. Evaluation of serum IAP and ASP levels].
Serum levels of immunosuppressive acidic protein (IAP) and acid soluble glycoprotein (ASP) were measured in 48 patients with urinary bladder carcinoma and 51 control subjects. Both IAP and ASP levels were significantly higher in the patients than in the control subjects, and the increase of these two serum substances seemed to be closely related to grading and staging of urinary bladder carcinoma. In many patients, serum IAP and ASP levels decreased after resection of tumors. There was an inverse correlation between IAP or ASP level and phytohemagglutinin (PHA)-induced lymphocyte blastogenesis (stimulation index, SI). This suggested an immunosuppressive effect of these serum factors. After chemotherapy of urinary bladder carcinoma, both IAP and ASP levels would decrease. It is suggested that serum IAP and ASP levels could be good indicators for evaluating the effect of chemotherapy.
D000368:Aged; D004341:Drug Evaluation; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D006801:Humans; D007111:Immunity, Cellular; D008297:Male; D009363:Neoplasm Proteins / Q000097:blood*; D009367:Neoplasm Staging; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000276:immunology* / Q000473:pathology
D006023:Glycoproteins; D009363:Neoplasm Proteins; C030193:immunosuppressive acidic protein