[Effect of phenobarbital, hexamidine and benzonal on the toxicity of dioxidine].
It has been shown in experiments on rats that phenobarbital, hexamidine and benzonal administered in doses producing the induction of liver microsomal enzymes reduce the total toxic action of dioxydin and pathological alterations in the adrenals induced by dioxydin. A possible mechanism of the effect under consideration is discussed.
D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D001463:Barbiturates / Q000494:pharmacology*; D001550:Benzamidines / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D004347:Drug Interactions; D004790:Enzyme Induction / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D010634:Phenobarbital / Q000494:pharmacology*; D011810:Quinoxalines / Q000633:toxicity*; D051381:Rats; D013997:Time Factors
D000890:Anti-Infective Agents; D001463:Barbiturates; D001550:Benzamidines; D011810:Quinoxalines; C001077:dioxidine; C018961:hexamidine; C002915:benzobarbital; D010634:Phenobarbital
Vliianie fenobarbitala, geksamidina i benzonala na toksichnost' dioksidina.