title: Hyperpolarization produced by methohexitone in the chick biventer cervicis skeletal muscle.
abstract: The effect of methohexitone on endplate potential and on depolarizations produced by acetylcholine (ACh) and tetraethylammonium (TEA) was studied in the isolated chick biventer cervicis skeletal muscle using a sucrose-gap recording technique. Methohexitone (5.5-180 uM) produced concentration-dependent hyperpolarization in the chick skeletal muscle without producing an initial contracture. Methohexitone had a differential effect on the depolarizations produced by ACh (5.5 uM- 11 mM) and TEA (0.95- 48 mM); it greatly reduced the ACh whereas it increased the TEA-induced responses. It was suggested that methohexitone had a dual postjunctional action, but a presynaptic effect was not ruled out.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002645:Chickens; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D008723:Methohexital / Q000494:pharmacology*; D009132:Muscles / Q000187:drug effects*; D009469:Neuromuscular Junction / Q000187:drug effects; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
chemical_list: D013757:Tetraethylammonium Compounds; D008723:Methohexital; D000109:Acetylcholine