Functional palatal incompetence in the fetal anticonvulsant syndrome.
We report two children with mild mental retardation and appreciable articulation difficulties whose mothers took phenobarbitone and phenytoin throughout their pregnancies. The speech difficulties in both children were due to malfunction of an anatomically normal palate.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008431:Maternal-Fetal Exchange; D010634:Phenobarbital / Q000009:adverse effects*; D010672:Phenytoin / Q000009:adverse effects*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D014681:Velopharyngeal Insufficiency / Q000139:chemically induced* / Q000151:congenital
D010672:Phenytoin; D010634:Phenobarbital