title: [Leu5]enkephalin inhibits norepinephrine-induced contraction of rat aorta.
abstract: Leucine-enkephalin produces a dose related decrease in the contractile response of spirally cut strips of rat aorta to norepinephrine (NE). The maximal effect (55.0 +/- 1.0 percent reduction in developed tension) occurs at a leucine-enkephalin concentration of 10(-10) M. The attenuation of contractile response is reversed by naloxone.
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D004743:Enkephalin, Leucine / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014661:Vasoconstriction / Q000187:drug effects
chemical_list: D004743:Enkephalin, Leucine; D009638:Norepinephrine