[The pancreatic lipase/colipase system].
Pancreatic lipase (triacylglycerol-acylhydrolase EC 3.1.1.3) hydrolyzes triglycerides on the lipid-water-boundary surfaces of micelles. The adsorption of the pancreatic lipase to the triglyceride boundary surfaces is inhibited by bile acid salts. Whereas colipase can be bound to boundary surfaces covered by bile acids and to pancreatic lipase. Colipase eliminates the inhibitory effect of physiologic concentrations of bile acid salts on the activity of lipase. The lipolysis by pancreatic lipase is characterized by activation of products and a biphasic kinetics. Extrapancreatic lipases of tongue, pharynx, oesophagus and stomach evoke the lipolysis of the fats contained in food.
D000818:Animals; D001647:Bile Acids and Salts / Q000502:physiology; D003089:Colipases / Q000378:metabolism*; D004041:Dietary Fats / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008049:Lipase / Q000378:metabolism*; D008066:Lipolysis; D010179:Pancreas / Q000201:enzymology*; D011506:Proteins / Q000378:metabolism*; D013379:Substrate Specificity; D014280:Triglycerides / Q000378:metabolism
D001647:Bile Acids and Salts; D003089:Colipases; D004041:Dietary Fats; D011506:Proteins; D014280:Triglycerides; D008049:Lipase
Das Pankreaslipase/Colipase-System.