title: Effects of agents known to antagonize the enhancement of in vitro transformation by 12-tetradecanoyl-phorbol-13-acetate (TPA) on the TPA suppression of metabolic cooperation.
abstract: Utilizing the phenomenon of metabolic cooperation in Chinese hamster V79 cells, we have studied the effects of agents which suppress the 12-tetradecanoyl-phorbol-13-acetate (TPA) enhancement of transformation in vitro, on the TPA suppression of cell-cell communication. None of the agents tested, namely all-trans-retinoic acid, the trimethyl methoxyphenyl analogue of N-ethyl-retinamide, soybean trypsin inhibitor, antipain nor superoxide dismutase, decreased the enhanced recovery effect of TPA on metabolic cooperation. One of the compounds, retinoic acid, significantly increased the % recovery above that observed for TPA alone.
mesh_terms: D000818:Animals; D000976:Antipain / Q000494:pharmacology*; D002450:Cell Communication / Q000187:drug effects*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D006224:Cricetinae; D009842:Oligopeptides / Q000494:pharmacology*; D010704:Phorbols / Q000037:antagonists & inhibitors*; D013482:Superoxide Dismutase / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000494:pharmacology*; D014361:Trypsin Inhibitors / Q000494:pharmacology*
chemical_list: D009842:Oligopeptides; D010704:Phorbols; D014361:Trypsin Inhibitors; D000976:Antipain; D014212:Tretinoin; D013482:Superoxide Dismutase; D013755:Tetradecanoylphorbol Acetate; C010832:motretinide