[Structural and functional findings in experimental blind loop syndrome].
Proximal and distal the blindsack a villus and crypt prolongation connected with a decreasing absorption of octanoate could be pointed out. The structural changes are very likely a hyperplasia of the mucosa. Within the blindsack a hyperplasia in connection with an accelerated proliferation of cells and an almost three and a halffold enlargement of the surface of the villi could be found. Simultaneously, the mucosa was damaged. An artificial bile duct as well as a neomycin therapy caused a decrease of the structural and functional changes but did not prevent the mucosal hyperplasia. These results are explained with adaptive processes of the small intestinal mucosa in a sense of hyperregeneration alterations of sprue typus.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001693:Biological Transport, Active; D001765:Blind Loop Syndrome / Q000188:drug therapy / Q000378:metabolism* / Q000473:pathology; D001835:Body Weight; D006801:Humans; D006965:Hyperplasia; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D009747:Nutritional Physiological Phenomena; D010649:Phenylalanine / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D000900:Anti-Bacterial Agents; D010649:Phenylalanine
Strukturelle und funktionelle Befunde beim experimentellen Blindsacksyndrom.