title: Age-dependent retention of [14C]DDT in the brain of the postnatal mouse.
abstract: Postnatal mice, at the age of 0 (newborn), 3, 7, 10, 15, 20 and 55 days, were given a single administration of dichlorodi[U-14C]phenyltrichloroethane [( 14C]DDT; 1.48 MBq/kg body wt.) per os. They were killed 24 h or 1 week post-treatment and the amount of radioactivity in the brain was measured. The most pronounced retention was found in mice receiving [14C]DDT on the tenth postnatal day. The activity found after 1 week was as high as that observed after 24 h, and it was also highest in this age category even though older mice displayed a higher activity 1 day after administration.
mesh_terms: D000367:Age Factors; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D002250:Carbon Radioisotopes; D003634:DDT / Q000378:metabolism* / Q000633:toxicity; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D002250:Carbon Radioisotopes; D003634:DDT