Effects of radiomodifiers on high and low LET responses in vivo.
The radioprotector WR-2721 and the radiosensitizer misonidazole have been studied for their influence on the response of mouse skin and tumours when irradiated with either single or fractionated doses of 240 kV X-rays or 3 MeV neutrons. The modification of radiosensitivity to neutrons was significantly less than that for X-rays, both for tumours and skin. When the two drugs were given in combination before single neutron doses, competitive interaction was observed.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004735:Energy Transfer; D005260:Female; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000532:radiotherapy; D009502:Neutrons; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D012867:Skin / Q000528:radiation effects; D014965:X-Rays
D011837:Radiation-Protective Agents; D011838:Radiation-Sensitizing Agents