title: [Toxic components of the venom of the Central Asian scorpion, Orthochirus scrobiculosus].
abstract: Four polypeptide neurotoxins, possessing paralytic activity for mice, were isolated from the venom of the Central Asian black scorpion Orthochirus scrobiculosus. All these toxins, Os-1 - Os-4, were shown to be homogeneous by disc-electrophoresis and N-terminal group analyses. The amino acid composition of the toxins was determined, methionine residues being found in toxin Os-1. The neurotoxin Os-3 was subjected to tryptic and chymotryptic hydrolyses and its total amino acid sequence was established. It was shown that neurotoxin Os-3 consists of 67 amino acid residues with four intramolecular disulfide bonds.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D006868:Hydrolysis; D007928:Lethal Dose 50; D051379:Mice; D009498:Neurotoxins / Q000032:analysis* / Q000633:toxicity; D010455:Peptides / Q000032:analysis; D012604:Scorpion Venoms / Q000032:analysis* / Q000633:toxicity
chemical_list: D009498:Neurotoxins; D010455:Peptides; D012604:Scorpion Venoms
vernacular_title: Toksicheskie komponenty iada sredneaziatskogo skorpiona Orthochirus scrobiculosus.