[Mechanism of hydrogen exchange in DNA].
The hydrogen exchange mechanism of DNA bases imino- and amino protons is explained according to a suggested exchangeable state model. This state can be formed as a result of significant structural fluctuations which are not complete base pair openings. The exchangeable state model represents the hydrogen-bonded complex of two nucleotide bases and one water molecule made up dynamically. Quantum-mechanical calculations for the values of energy as the function of H-bond proton positions in the complex were carried out and the two-proton positions in the complex were carried out and the two-proton transfer is shown to be possible. The suggested model allows to give a noncontradictary interpretation of the hydrogen exchange data in double-helical polynucleotides.
D004247:DNA; D006859:Hydrogen; D006860:Hydrogen Bonding; D007700:Kinetics; D008956:Models, Chemical; D008958:Models, Molecular
D006859:Hydrogen; D004247:DNA
O mekhanizme vodorodnogo obmena v DNK.