[Lung tissue in intratracheal exposure to mine dust].
The experiment was performed 64 albino female rats by a single, intretracheal treatment with 50 mg mine dust. Dynamic biochemical studies were carried out - by 3th and 6th months of the experiment. The data obtained were compared with the changes observed in the positive controls - DQ12 and Ti02 The activity of the oxidation-reduction enzymes and hydrolytic ones was enhanced, the content of sulphhydryl groups and soluble proteins was increased. The results obtained are an evidence of the advancing metabolic disturbances in pulmonary tissue, being better manifested by 6th month of the experiment.
D000135:Acid Phosphatase / Q000378:metabolism; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004391:Dust / Q000009:adverse effects*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D007267:Injections; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000201:enzymology; D008906:Mining; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014132:Trachea
D004391:Dust; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase
Belodrobnata tŭkan pri intratrakhealno tretirane s rudnichen prakh.