Effect of premedication with diazepam, morphine or nalbuphine on gastrointestinal motility after surgery.
Premedication with nalbuphine and morphine delayed gastric emptying in the period after operation, but oral diazepam did not. All three drugs delayed co-ordinated intestinal motility, although nalbuphine did so for less than half as long as morphine. This property of nalbuphine, if confirmed, could make it a valuable analgesic drug in the period after operation.
D000082:Acetaminophen / Q000097:blood; D000328:Adult; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D009019:Morphinans / Q000494:pharmacology*; D009020:Morphine / Q000494:pharmacology*; D009266:Nalbuphine / Q000494:pharmacology*; D011184:Postoperative Period; D011229:Preanesthetic Medication; D013997:Time Factors
D009019:Morphinans; D000082:Acetaminophen; D009020:Morphine; D009266:Nalbuphine; D003975:Diazepam