Gentamicin penetration into diseased appendix tissue.
Gentamicin concentrations in appendix tissue, serum, and peritoneal fluid were obtained in suspected cases of gangrenous or perforated appendicitis. Despite widely ranging gentamicin concentrations, no infectious complications developed. Correlations were made between the pathologic state of the tissue and the tissue gentamicin concentrations. Correlations were also made with tissue gentamicin concentrations and the time after the antibiotic dose to the time of sampling.
D000328:Adult; D001064:Appendicitis / Q000188:drug therapy / Q000378:metabolism*; D001065:Appendix / Q000378:metabolism*; D001826:Body Fluids / Q000378:metabolism; D005839:Gentamicins / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D011292:Premedication
D005839:Gentamicins