title: The ability of certain anorexic drugs to suppress food consumption depends on the nutrient composition of the test diet.
abstract: The effects of five anorexic agents on food consumption were tested in rats offered single, isocaloric, isonitrogenous diets differing in carbohydrate content. Three of the test agents, d-amphetamine, benzphetamine and chlorphentermine, are sympathomimetic and cause CNS stimulation; the others, MK-212 and d-fenfluramine, are thought to facilitate serotonin-mediated neurotransmission. At ED50 doses, the sympathomimetic drugs reduced food consumption whether the test diet was rich (75% dextrin) or poor (25% dextrin) in carbohydrate. In contrast, MK-212 and d-fenfluramine failed to reduce consumption of the 25% dextrin test diet. These observations suggest that anorexic drugs like d-amphetamine and d-fenfluramine do not act via a common "amphetamine receptor," and are compatible with earlier observations, made on rats given diet pairs simultaneously, that enhanced serotoninergic neurotransmission selectively suppresses appetite for carbohydrates.
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D001589:Benzphetamine / Q000494:pharmacology; D002745:Chlorphentermine / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004435:Eating / Q000187:drug effects*; D005277:Fenfluramine / Q000494:pharmacology; D008297:Male; D011719:Pyrazines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology
chemical_list: D001067:Appetite Depressants; D004040:Dietary Carbohydrates; D011719:Pyrazines; D001589:Benzphetamine; D005277:Fenfluramine; D012701:Serotonin; C014896:6-chloro-2-(1-piperazinyl)pyrazine; D002745:Chlorphentermine; D003913:Dextroamphetamine