[Toxicological characteristics of disodium salt of N-lauroyl-L-glutamic acid--a surface-active agent used in the food processing industry].
To synthesize the disodium salt of N-lauroyl-L-glutamic acid (LG-Na2), use was made of the chloranhydride method with some modifications. The yield of the product was 85%. LG-Na2 possesses good surface-active properties and an emulsifying effect. The critical concentration of micelloformation of LG-Na2 is 6 10(-3) mol/l. LG-Na2 is a non-toxic compound. It is not cumulated in the animals' body. The LD50 for albino rats per os exceeds 10 000 mg/kg, that for mice 6500 mg/kg. It was shown in subacute experiments in rats that LG-Na2 did not produce any substantial influence on the animals' status or on some biochemical and morphological indicators of blood and organs. The authors suggest a tentative level of a safe oral action of LG-Na2 on man (10 mg per kg bw/day). LG-Na2 is likely to be widely used in food industry.
D000311:Adrenal Glands / Q000378:metabolism; D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002802:Cholinesterases / Q000378:metabolism; D005506:Food Contamination / Q000032:analysis*; D005525:Food-Processing Industry; D006454:Hemoglobins / Q000032:analysis; D007850:Lauric Acids / Q000633:toxicity*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011506:Proteins / Q000378:metabolism; D051381:Rats; D013501:Surface-Active Agents; D013737:Testis / Q000378:metabolism
D006454:Hemoglobins; D007850:Lauric Acids; D011506:Proteins; D013501:Surface-Active Agents; C030358:lauric acid; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D002802:Cholinesterases; D001205:Ascorbic Acid
Toksikologicneskaia kharakteristika dinatrievoĭ soli N-lauroil-L-glutaminovoĭ kisloty--poverkhnostno-aktivnogo veshchestva dlia pishchevoĭ promyshlennosti.