Retention of labelled 5-iodo-2-deoxyuridine after intratumorous injection as a possible indicator of the cellular kinetics.
On the basis of an experimental model of the Lewis lung carcinoma a possibility was checked of obtaining basic kinetic data about the individual proliferation of tumour cells by a method of measuring the incorporation of labelles 125I 5-iodo-2-deoxyuridine intratumorously with a subsequent measurement of the retained activity in the tumour. These activity, which resides in the tumour for a time longer than 24 hours depends on the fraction of cells, that in the synthetic part of the cell cycle at the time of the injection.
D000818:Animals; D002455:Cell Division; D004273:DNA, Neoplasm / Q000378:metabolism; D007065:Idoxuridine / Q000008:administration & dosage / Q000378:metabolism*; D007267:Injections; D007700:Kinetics; D008175:Lung Neoplasms / Q000378:metabolism / Q000473:pathology*; D051379:Mice; D008810:Mice, Inbred C57BL
D004273:DNA, Neoplasm; D007065:Idoxuridine