title: Mycoplasma pneumoniae: acute illness, antibiotics, and subsequent pulmonary function.
abstract: One hundred and eight children presenting with Mycoplasma pneumoniae infection were assessed during the acute illness and followed for three years. The incidence of wheezing with the acute infection (40%) was greater than expected in a normal childhood population. The initial illness precipitated wheezing for the first time in some subjects but others wheezed only with the acute illness. In non-asthmatic subjects significant bronchodilator responsiveness was present one month after infection. Children given erythromycin during the first seven days of their illness had a significantly shorter fever duration compared with those treated inappropriately. No significant effects of treatment were noted on pulmonary function three years later but non-asthmatic children had abnormal mean forced expiratory volume in one second and forced expiratory flow after 50% of the expired vital capacity compared with 64 healthy controls. These findings indicate impaired function three years after initial infection.
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000150:complications; D002648:Child; D002675:Child, Preschool; D004917:Erythromycin / Q000627:therapeutic use; D005260:Female; D005540:Forced Expiratory Flow Rates; D005541:Forced Expiratory Volume; D006801:Humans; D007223:Infant; D008168:Lung / Q000503:physiopathology*; D008297:Male; D011019:Pneumonia, Mycoplasma / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*; D012135:Respiratory Sounds; D013997:Time Factors; D014797:Vital Capacity
chemical_list: D004917:Erythromycin