title: Cerebroprotective effect of dexamethasone by increasing the tolerance to hypoxia and preventing brain oedema in newborn piglets with experimental pneumothorax.
abstract: The effect of dexamethasone (DXM) pretreatment in newborn piglets with experimental pneumothorax (EPT) was studied. Neither low DXM doses nor those administered 1 or 2 h prior to the induction of EPT were found to be effective against its course. In contrast, 5 mg/kg of body wt. of DXM given subcutaneously 4 h prior to EPT improved significantly both the tolerance and laboratory data of the animals. The extent of brain oedema, measured 4 h after recovery, was also considerably lowered. Actinomycin D pretreatment prevented almost completely the beneficial effect offered by DXM suggesting the involvement of newly synthesized protein(s) in the cerebroprotective effect of DXM.
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D001929:Brain Edema / Q000378:metabolism / Q000517:prevention & control*; D003609:Dactinomycin / Q000494:pharmacology; D003907:Dexamethasone / Q000627:therapeutic use*; D005260:Female; D002534:Hypoxia, Brain / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D011030:Pneumothorax / Q000188:drug therapy*; D013552:Swine; D014867:Water / Q000032:analysis
chemical_list: D009419:Nerve Tissue Proteins; D014867:Water; D003609:Dactinomycin; D003907:Dexamethasone