Substantia innominata: critical link in the behavioral expression of mesolimbic dopamine stimulation in the rat.
The 'supersensitive' locomotor response to apomorphine resulting from 6-hydroxydopamine (6-OHDA)-induced denervation of the nucleus accumbens (N.Acc.) was studied in animals following selective damage to cell bodies within the substantia innominata (SI) and lateral preoptic region (LPO). Ibotenic acid-induced lesions of the SI and LPO dramatically attenuated the locomotor response to apomorphine in 6-OHDA-infused animals. Thus, the locomotor response that follows dopaminergic stimulation within the N.Acc. depends to a great degree on the integrity of cells within the SI and LPO region.
D000818:Animals; D001479:Basal Ganglia / Q000502:physiology*; D001931:Brain Mapping; D004298:Dopamine / Q000502:physiology*; D007051:Ibotenic Acid / Q000494:pharmacology; D008124:Locomotion; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009434:Neural Pathways / Q000502:physiology; D009714:Nucleus Accumbens / Q000502:physiology*; D011301:Preoptic Area / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000502:physiology*; D013377:Substantia Innominata / Q000502:physiology*
D007051:Ibotenic Acid; D004298:Dopamine