Pancreatic polypeptide response to sham feeding in man.
The relationship between gastric acid secretion and the release of pancreatic polypeptide (PP) during modified sham feeding was studied in 29 duodenal ulcer patients and 10 healthy controls. Ulcer patients showed higher basal plasma PP levels than age-matched controls (p less than 0.01). Acid secretion and PP levels were stimulated in the majority of patients and controls during sham feeding; however, no correlation was found between basal and vagally stimulated acid secretion and basal PP levels. Gastrin levels did not change in both groups. It is concluded from the present study that changes in plasma PP levels do not reflect sham feeding induced stimulation of the parietal cells.
D000328:Adult; D000368:Aged; D004381:Duodenal Ulcer / Q000378:metabolism; D004435:Eating; D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000097:blood; D006801:Humans; D008875:Middle Aged; D010191:Pancreatic Polypeptide / Q000097:blood*; D014630:Vagus Nerve / Q000502:physiology
D005755:Gastrins; D010191:Pancreatic Polypeptide