title: [Xenogeneic transplantation of human malignant melanoma under high-dose immunosuppression].
abstract: The application of methotrexate led in Wistar rats to the known toxic effects. Malignant human melanoma cells can be transplanted in pretreated animals by contribution of the immunosuppression by means of Azathioprine. The transplanted tumors spread and proliferate in the organism of the receiver.
mesh_terms: D000818:Animals; D001379:Azathioprine / Q000627:therapeutic use*; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D008545:Melanoma / Q000276:immunology* / Q000473:pathology; D008727:Methotrexate / Q000627:therapeutic use*; D009368:Neoplasm Transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D014183:Transplantation, Heterologous / Q000379:methods*
chemical_list: D001379:Azathioprine; D008727:Methotrexate
vernacular_title: Beitrag zur xenogenen Transplantation menschlicher maligner Melanome unter hochdosierter Immunsuppression.