[Cellular immune reactions to the multiple administration of a chromatographic inactivated influenza vaccine in an experiment].
The administration of inactivated chromatographic influenza vaccine to mice in three injections induced the formation of the pronounced clone of antigen-reactive lymphocytes, detected in the leukocyte blast transformation test. Slight fluctuations in the phytohemagglutinin level and lipopolysaccharide response in mice subjected to multiple immunization with the inactivated vaccine indicated that this preparation produced no damaging effect on the T- and B-lymphocyte populations.
D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization / Q000379:methods; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology / Q000302:isolation & purification; D008213:Lymphocyte Activation / Q000187:drug effects; D008221:Lymphoid Tissue / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated
Kletochnye immunnye reaktsii na mnogokratnoe vvedenie inaktivirovannoĭ grippoznoĭ khromatograficheskoĭ vaktsimy v éksperimente.