[Electrochemical reduction of the anthracycline antibiotic 5-iminodaunorubicin. Isolation and structural clarification of the reduction products].
After electrochemical reduction of the potential cancer chemotherapeutic 5-iminodaunorubicine two new compounds, were isolated purely by chromatographic separation. Based on 1H-NMR, IR-, UV/VIS- and MS-investigations the one reaction product was identified as 7-desoxy-5-iminodaunorubicinone as expected, while the other was proofed as 9-acetyl-9,12-dihydroxy-4-methoxy-7,8,9,10-tetrahydroxy-6,11-naphthac enchinone.
D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000032:analysis; D004563:Electrochemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D011048:Polarography; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
C018979:5-iminodaunorubicin; D003630:Daunorubicin
Elektrochemische Reduktion des Anthracyclin-Antibioticums 5-Iminodaunorubicin. Zur Isolierung und Strukturaufklärung der Reduktionsprodukte.