title: Fertility regulation in nursing women. VI. Contraceptive effectiveness of a subdermal progesterone implant.
abstract: Six progesterone pellets implanted subdermally were tested as contraceptive method for lactating women. One pregnancy was diagnosed in 1614 woman-months of observation, a failure rate which was similar to that observed in a contemporary group of Copper T users. Nineteen pregnancies were diagnosed in the 677 woman-months observed in untreated lactating women. The progesterone implants were effective when administered either at 30, 60 or 240 days after delivery. The duration of the effective life was 5 months and fertility was quickly restored afterwards. There were no deleterious effects upon maternal or infant health or upon lactation and the rate of child growth. The main problem encountered was the occurrence of pellet expulsion at a variable rate which appeared related to the manufacturing procedure.
mesh_terms: D000293:Adolescent; D000328:Adult; D001942:Breast Feeding; D004343:Drug Implants; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005500:Follow-Up Studies; D006801:Humans; D007435:Intrauterine Devices, Copper; D007774:Lactation / Q000187:drug effects*; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage* / Q000097:blood
chemical_list: D004343:Drug Implants; D011374:Progesterone