Fibrinolytic activity in plasma and vessels of the hind leg in rats treated with ethinylestradiol and D-norgestrel.
The separate effect of ethinylestradiol (4 micrograms/kg b.w./day) and d-norgestrel (20 micrograms/kg b.w./day) on the fibrinolytic activity in plasma and in vessel walls of the hind leg was investigated in an experimental study on rats. No hormonal effect on the fibrinolytic activity in plasma was registered. However, a significantly increased fibrinolytic activity in the vessel wall of the distal hind leg was demonstrated in the d-norgestrel-treated rats with plasma levels well below those reported in women using combined contraceptive pills. On the contrary, the fibrinolytic activity of the vessel wall was uninfluenced in the ethinylestradiol-treated rats with plasma levels corresponding to those in women on contraceptive pills containing 30 micrograms ethinylestradiol.
D000818:Animals; D004997:Ethinyl Estradiol / Q000097:blood / Q000494:pharmacology*; D005342:Fibrinolysis / Q000187:drug effects*; D006614:Hindlimb / Q000098:blood supply*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009644:Norgestrel / Q000097:blood / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D009644:Norgestrel; D004997:Ethinyl Estradiol