[Antitumor activity of bacterial fractions and related synthetic compounds].
We have purified the cell-wall skeletons (CWS) of Mycobacterium bovis BCG, Nocardia rubra, Propionibacterium acnes and Listeria monocytogenes as the adjuvant-active principles of these bacterial cells. These cell-wall skeleton preparations were shown to have antitumor activities in experimental tumor systems. Especially BCG-CWS and N. rubra-CWS were applied for the treatment of human cancer. The synthetic immunoadjuvants such as cord factor, mycoloyl and quinonyl derivatives of N-acetylmuramyldipeptides were prepared and their immunological properties were investigated. The effectiveness of synthetic adjuvants on the stimulation of nonspecific host resistance against bacterial and viral infections was also discussed.
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D001500:BCG Vaccine / Q000276:immunology / Q000627:therapeutic use*; D002473:Cell Wall / Q000276:immunology; D003311:Cord Factors / Q000276:immunology; D006801:Humans; D007251:Influenza, Human / Q000276:immunology; D008087:Listeria / Q000276:immunology; D009369:Neoplasms / Q000276:immunology / Q000628:therapy*; D009615:Nocardia / Q000276:immunology; D013274:Stomach Neoplasms / Q000276:immunology / Q000628:therapy
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D001500:BCG Vaccine; D003311:Cord Factors