Destruction of acetylcholine receptor by decaying 125I-alpha-bungarotoxin.
Decay of 125I in 125I-alpha-bungarotoxin bound to detergent-solubilized acetylcholine receptor from Torpedo californica electric tissue results in the inactivation of virtually all of the directly occupied and of the second toxin-binding sites. This finding establishes the usefulness of 125I-labeled ligands for binding-site multiplicity analysis of proteins.
D000818:Animals; D002038:Bungarotoxins / Q000378:metabolism*; D007457:Iodine Radioisotopes / Q000378:metabolism*; D007553:Isotope Labeling; D008433:Mathematics; D011950:Receptors, Cholinergic / Q000378:metabolism*; D014101:Torpedo
D002038:Bungarotoxins; D007457:Iodine Radioisotopes; D011950:Receptors, Cholinergic