Cerebral high energy phosphates after hypoxic-hypotension: effect of verapamil and nifedipine.
Rats were subjected to 30 minutes of hypoxic-hypotension and then allocated to one of four treatment groups. Group I was resuscitated by restoration of FIO2 = 30% and reinfusion of shed blood plus an equal volume of additional saline. Group II received in addition nifedipine, 10 micrograms/kg, and groups III and IV received in addition either verapamil, 0.2 mg/kg or 1 mg/kg, respectively. Significantly (P less than 0.01) higher concentrations of creatine phosphate and ATP were present in the brain after nifedipine and after 1 mg/kg verapamil treatment.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002560:Cerebrovascular Circulation; D007022:Hypotension / Q000188:drug therapy / Q000378:metabolism*; D002534:Hypoxia, Brain / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D009543:Nifedipine / Q000494:pharmacology; D010710:Phosphates / Q000378:metabolism*; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014700:Verapamil / Q000494:pharmacology
D010710:Phosphates; D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D014700:Verapamil; D009543:Nifedipine