The effect of omeprazole on gastric emptying in patients with duodenal ulcer disease.
The effect of a single oral dose of omeprazole (90 mg) on gastric emptying was assessed with a dual isotope scintigraphic technique in eight patients with a history of duodenal ulcer disease. Omeprazole had no significant effect on solid or liquid gastric emptying. The bioavailability (AUC0-2 h) of omeprazole in all patients was greater than that required for total suppression of acid secretion. No adverse clinical or laboratory effects were observed.
D000328:Adult; D001562:Benzimidazoles / Q000097:blood / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000503:physiopathology*; D005746:Gastric Emptying / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009853:Omeprazole
D001562:Benzimidazoles; D009853:Omeprazole