[Immunomodulating action of levamisole in influenzal infection in mice].
The time of the activation of the regulatory lymphocyte subpopulation in the spleen and the influence of levamisole on the course of influenza infection in mice were studied in parallel. The study revealed that the final effect of the immunomodulating action of levamisole was determined by the concrete phase of the regulatory activity of lymphocytes. At the same time the injection of the preparation at the peak of helper activity induced a transitory decrease in antibody formation and, in the fatal form of the infection, a rise in the death rate among the animals. The probable role of levamisole-activated macrophages in the transitory suppression of immune response in mice during influenza infection is discussed.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D000917:Antibody Formation / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D009980:Influenza A virus / Q000276:immunology; D007978:Levamisole / Q000276:immunology* / Q000627:therapeutic use; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009976:Orthomyxoviridae Infections / Q000188:drug therapy / Q000276:immunology* / Q000401:mortality; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000914:Antibodies, Viral; D007978:Levamisole
Immunomoduliruiushchee deĭstvie levamizola pri grippoznoĭ infektsii mysheĭ.