[Effects of autonomic blockades, beta-adrenergic agent and cholinergic agent on the FHR variability of "Shiba goats"].
The effects of atropine, propranolol, isoproterenol and acetylcholine on the fetal heart rate variability were studied using chronically prepared fetal goats. When atropine, propranolol and atropine-propranolol were injected the STVs decreased by 45.2%, 43.2% and 57.3%, respectively; LTVs also decreased by 72.3%, 52.2% and 73.3%, respectively. STVs and LTVs increased by 39.5% and 34.5% with the injection of isoproterenol, and decreased by 27.6% and 22.7% with acetylcholine. These results suggest that FHR variability represents a change in the heart rate due to reciprocal innervation of adrenergic and cholinergic systems; moreover, the activity of the heart itself exerts some influence on variability. It is also suggested that LTV more strongly reflects autonomic nervous tone whereas STV more strongly reflects heart activity.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D005260:Female; D005318:Fetal Heart / Q000187:drug effects* / Q000502:physiology; D005323:Fetal Monitoring; D006041:Goats; D006339:Heart Rate / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology*; D011247:Pregnancy; D011433:Propranolol / Q000494:pharmacology*
D001285:Atropine; D011433:Propranolol; D007545:Isoproterenol; D000109:Acetylcholine