Steroid-dependent nephrotic syndrome in lupus nephritis. Response to chlorambucil.
Nephrotic syndrome associated with mesangial lupus nephritis developed in a young woman. The heavy proteinuria exhibited a striking steroid-dependent course during a three-year period of time, with ten relapses occurring whenever attempts were made to withdraw prednisone therapy. A prolonged remission was induced by the administration of chlorambucil.
D000328:Adult; D002699:Chlorambucil / Q000627:therapeutic use*; D005260:Female; D005921:Glomerulonephritis / Q000150:complications*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D009404:Nephrotic Syndrome / Q000139:chemically induced* / Q000188:drug therapy; D011241:Prednisone / Q000009:adverse effects* / Q000627:therapeutic use; D011507:Proteinuria / Q000188:drug therapy; D012008:Recurrence; D013375:Substance Withdrawal Syndrome / Q000139:chemically induced*
D002699:Chlorambucil; D011241:Prednisone