Influence of acute diuresis on calcium balance--a comparative study of furosemide and azosemide.
The influence of acute diuresis on calcium balance induced by furosemide (FM) and azosemide (AM) was observed and compared in the human body. The treatment resulted in significant diuresis (FM: 2488 +/- 163 ml; AM: 2930 +/- 109 ml for 6 hours) and calciuresis (FM: 132.0 +/- 15.2 mg; AM: 181.0 +/- 16.6 mg for 6 hours). In spite of the urinary calcium loss, the serum calcium concentrations were elevated by both drugs. The elevation was also found even when the correction to serum protein concentrations was performed, and the magnitude of this change was less by AM than by FM. Plasma parathyroid hormone (PTH) concentrations were slightly elevated by AM only at 6 hours, but they remained unchanged by FM. This mild elevation of PTH could not be explained sufficiently by the concentration changes of serum calcium as noted above, and might be caused by factors other than serum calcium. The alkaline phosphatase concentrations corrected by means of serum protein concentrations were unchanged in both drugs, and it was suggested that the calciuresis may not extend to bone calcium remodeling at least in such a short-term experiment.
D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D002118:Calcium / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004231:Diuresis / Q000187:drug effects*; D004232:Diuretics / Q000494:pharmacology*; D005260:Female; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood / Q000652:urine; D013424:Sulfanilamides / Q000494:pharmacology*; D013997:Time Factors; D013777:Tetrazoles; D013876:Thiophenes; D000096926:Benzenesulfonamides
D000469:Alkaline Phosphatase; D001798:Blood Proteins; D002118:Calcium; D004232:Diuretics; D005665:Furosemide; D010281:Parathyroid Hormone; D010758:Phosphorus; D013424:Sulfanilamides; C018222:azosemide; D013777:Tetrazoles; D013876:Thiophenes; D000096926:Benzenesulfonamides