[Diabetogenic action of alloxan in short-term termination of the blood supply to the pancreas and spleen].
It has been shown that the development of alloxan diabetes in rats and the appearance of diabetogenic factor in blood is caused by the direct alloxan action on pancreas and spleen--the organs supplying by blood through the spleen artery. The stopping of blood circulation in that artery preserves rat's organism from the development of general toxic effect of alloxan. The inactivation of alloxan as a diabetogenic agent has been shown after its 5-minute at 37 degrees C incubation with blood. It has been established that the half activity of intravenous injected alloxan disappears in rat's organism during 50 s. and does not depend on alloxan sensitivity of animals.
D000496:Alloxan / Q000097:blood; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000209:etiology* / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D006207:Half-Life; D008297:Male; D010179:Pancreas / Q000098:blood supply* / Q000187:drug effects; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D013154:Spleen / Q000098:blood supply* / Q000187:drug effects; D013997:Time Factors
D001786:Blood Glucose; D000496:Alloxan
Izuchenie diabetogennogo deĭstviia alloksana pri kratkovremennom prekrashchenii krovosnabzheniia podzheludochnoĭ zhelezy i selezenki.