Experimental studies of the anatomical and functional characteristics of kangaroo aortic valve bioprostheses.
In many tests done in vitro and in vivo on porcine aortic valve grafts, high pressure gradients were found under normal as well as under stress conditions. The transvalvular pressure difference is due to the immobility of the right aortic porcine leaflet that is fixed tightly to the muscular septum of the ventricle. Our own studies of 24 kangaroo hearts show different anatomical features: the right leaflet is practically free in this movement. Thus the maximum orifice area of the kangaroo aortic valve is reduced by only 24.2 per cent, whereas the porcine valve shows a reduction of 36.5 per cent. This difference proved to be highly significant (P less than 0.001). Therefore, in cooperation with Hancock Laboratories, kangaroo aortic valve grafts were tested as xenotransplants, using a pulse duplicator. The first results show that larger orifice areas are achieved by kangaroo valves one or two sizes smaller than their porcine counterparts.
D000818:Animals; D001021:Aortic Valve; D001705:Bioprosthesis / Q000592:standards; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology; D006350:Heart Valve Prosthesis / Q000592:standards; D006439:Hemodynamics; D007614:Macropodidae; D008394:Marsupialia; D013552:Swine