Microiontophoretic bicuculline restores binocular responses to visual cortical neurons in strabismic cats.
Rearing cats with surgically induced strabismus resulted in an abnormally high percentage (80%) of monocularly driven neurons in visual cortex. Microiontophoretic application of the GABA antagonist bicuculline restored binocular responses to over 50% of these monocular cells. Elevation of spontaneous rate by glutamate failed to produce binocularity. These results indicate that intracortical inhibition plays a role in the abnormal ocular dominance distribution of strabismic cats.
D000818:Animals; D001640:Bicuculline / Q000008:administration & dosage / Q000494:pharmacology*; D002415:Cats; D004292:Dominance, Cerebral; D007839:Functional Laterality; D008845:Microinjections; D009474:Neurons / Q000502:physiology*; D013285:Strabismus / Q000503:physiopathology*; D014793:Visual Cortex / Q000503:physiopathology*
D001640:Bicuculline