title: Acute diverticulitis. Comparison of treatment in immunocompromised and nonimmunocompromised patients.
abstract: The clinical course and required treatment of diverticulitis were reviewed in 76 nonimmunocompromised patients and 10 immunocompromised patients. The immunocompromised patients presented with either minimal or no symptoms and findings. Therefore, to make the diagnosis of acute diverticulitis in this group, a high index of suspicion must be maintained. The required treatment varied considerably between the two groups. In 45 nonimmunocompromised patients (76 percent), medical therapy was successful. Medical treatment failed in the other 14 patients (24 percent). However, the compromised group had no patients in whom medical therapy was successful (100 percent failure rate). Thirty-one of the nonimmunocompromised patients (41 percent) required an operation, whereas 100 percent of the immunocompromised patients with acute diverticulitis required an operation. By relating postoperative complications, we were unable to determine the initial operative procedure of choice in the nonimmunocompromised group; however, in the immunocompromised group, colostomy and resection had fewer surgical complications than colostomy and drainage. The immunocompromised patient with acute diverticulitis requires operation. We believe the operation of choice is colostomy and resection of the involved segment.
mesh_terms: D000208:Acute Disease; D000328:Adult; D000368:Aged; D001379:Azathioprine / Q000627:therapeutic use; D003125:Colostomy; D003520:Cyclophosphamide / Q000627:therapeutic use; D004239:Diverticulitis, Colonic / Q000188:drug therapy / Q000601:surgery*; D004322:Drainage; D005260:Female; D006801:Humans; D007108:Immune Tolerance; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011241:Prednisone / Q000627:therapeutic use; D012086:Reoperation; D012189:Retrospective Studies
chemical_list: D003520:Cyclophosphamide; D001379:Azathioprine; D011241:Prednisone