Neurocrest and colonic tumors: new clinical syndrome. Report of three cases.
This report describes three patients with both multiple intestinal polyps and tumors of neural crest origin. This combination of findings may represent a new clinical syndrome. The embryologic relationships between tumors derived from endoderm and tumors derived from neurocrest are described. An inherent defect in tissue proliferation or repair is postulated to explain the abnormal growth in these two different cell lines.
D000236:Adenoma / Q000196:embryology; D000310:Adrenal Gland Neoplasms / Q000196:embryology; D000328:Adult; D002276:Carcinoid Tumor / Q000196:embryology / Q000556:secondary; D002277:Carcinoma / Q000196:embryology / Q000556:secondary; D003110:Colonic Neoplasms / Q000196:embryology*; D004707:Endoderm; D006801:Humans; D007417:Intestinal Polyps / Q000196:embryology; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000196:embryology*; D009432:Neural Crest; D010673:Pheochromocytoma / Q000196:embryology* / Q000556:secondary; D013577:Syndrome; D013964:Thyroid Neoplasms / Q000196:embryology