[Possibility of N-dimethylnitrosamine formation after parenteral administration of amidopyrine and nitrite to rats].
The intravenous or intraperitoneal injection of amidopyrine and sodium nitrite to rats induces liver necrosis caused by endogenic synthesis of carcinogenic N-nitrosodimethylamine (NDMA). Ascorbic acid, which inhibits this synthesis when injected intravenously, phenobarbital, which is an inductor of enzymatic decomposition when injected intraperitoneally, prevented the formation of necrosis.
D000632:Aminopyrine / Q000008:administration & dosage / Q000378:metabolism*; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D004128:Dimethylnitrosamine / Q000378:metabolism*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009336:Necrosis; D009573:Nitrites / Q000008:administration & dosage / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats
D009573:Nitrites; D000632:Aminopyrine; D004128:Dimethylnitrosamine; D001205:Ascorbic Acid; D010634:Phenobarbital
Vozmozhnost' obrazovaniia N-nitrozodimetilamina pri parenteral'nom vvedenii krysam amidopirina i nitrita.