Antiinflammatory activity of N-(2-benzoylphenyl)alanine derivatives.
A series of N-(2-benzoylphenyl)alanine derivatives were synthesized and tested for antiinflammatory activity in the Evans blue-carrageenan induced pleural effusion assay. The target compounds were envisioned to bind to a receptor site on the cyclooxygenase enzyme by a mechanism first proposed by Appleton and Brown. Of the 21 compounds prepared, two were found to be one-tenth as potent as indomethacin in the pleurisy model and one compound was tested and found to be weakly active in the adjuvant arthritis model.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D001168:Arthritis / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D055598:Chemical Phenomena; D002621:Chemistry; D004195:Disease Models, Animal; D007202:Indicators and Reagents; D007213:Indomethacin / Q000627:therapeutic use; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000627:therapeutic use; D010998:Pleurisy / Q000188:drug therapy; D051381:Rats; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D007202:Indicators and Reagents; D010649:Phenylalanine; C042925:N-(2-benzoylphenyl)alanine; D007213:Indomethacin