Fecal lipid chromatography--identification of an unusual fraction in relation to colon cancer.
The thin-layer chromatography of fecal lipids with revelation by phosphomolybdic reagent indicates the presence of an unusual fraction only in colon cancer patients. After isolation and identification, this fraction appears to be composed of coprostanol and its derivatives. The quantitative analysis of fecal neutral steroids in colon cancer patients compared to controls, patients with other digestive diseases and polypi shows a positive relationship between this fraction and colon cancer.
D000328:Adult; D000368:Aged; D055598:Chemical Phenomena; D002621:Chemistry; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D003110:Colonic Neoplasms / Q000378:metabolism*; D003111:Colonic Polyps / Q000378:metabolism; D005243:Feces / Q000032:analysis*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008055:Lipids / Q000302:isolation & purification*; D008297:Male; D008875:Middle Aged; D013261:Sterols / Q000302:isolation & purification
D008055:Lipids; D013261:Sterols