title: 2-Pyrrolidinone and succinimide endogenously present in several mammalian species.
abstract: 2-Pyrrolidinone and succinimide were identified in blood plasma of man, rat, and mouse. Dog plasma contained only traces of 2-pyrrolidinone not exceeding significantly the detection limit of our GCMS-method. Succinimide but not 2-pyrrolidinone could also be found in the brains of rat and mouse. Evidence is presented for a metabolic pathway leading from 2-pyrrolidinone to succinimide, with 5-hydroxy-2-pyrrolidinone as an intermediate.
mesh_terms: D000328:Adult; D000818:Animals; D001711:Biotransformation; D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid; D004285:Dogs; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D051379:Mice; D011760:Pyrrolidinones / Q000032:analysis* / Q000097:blood; D051381:Rats; D013388:Succinimides / Q000032:analysis* / Q000097:blood
chemical_list: D011760:Pyrrolidinones; D013388:Succinimides; C032620:succinimide; C024842:5-hydroxy-2-pyrrolidone; C028537:2-pyrrolidone