title: A simple method for measuring the respiratory uptake of carbon monoxide in unanesthetized rats: an application to rats acutely exposed to ozone.
abstract: A simple method for measuring the respiratory uptake of carbon monoxide in unanesthetized rats is described. This method is easy to operate, inexpensive, and is a sensitive means for detecting effects of short-term exposure to low concentrations of ozone. In this study, the exposure of 6- to 7-wk-old rats to 2 ppm ozone for 3 hr and 1 ppm ozone for 3-6 hr resulted in an apparent decrease in carbon monoxide uptake without significant change in the lung weight.
mesh_terms: D000818:Animals; D002248:Carbon Monoxide; D008168:Lung / Q000033:anatomy & histology; D008297:Male; D009929:Organ Size; D010126:Ozone / Q000494:pharmacology*; D011653:Pulmonary Diffusing Capacity; D051381:Rats; D011919:Rats, Inbred Strains; D012129:Respiratory Function Tests / Q000379:methods
chemical_list: D010126:Ozone; D002248:Carbon Monoxide