Association of Fanconi's anemia and squamous-cell carcinoma of the lower female genital tract with condyloma acuminatum. A report of two cases.
Two young women had Fanconi's anemia and genital human papillomavirus infection associated with multicentric genital neoplasia. One of these women represented the first documented case of death from vaginal squamous carcinoma associated with Fanconi's anemia. In these two women an apparent biologic compression of the natural history of vulvar and vaginal carcinoma was observed. The finding of condyloma acuminatum in both of them prior to the onset of carcinoma suggests a partial causal association. Involvement of the cervix, vagina, vulva and perianal epithelium by the oncogenic process implies that a field effect occurred in those areas.
D000328:Adult; D000741:Anemia, Aplastic / Q000150:complications*; D002278:Carcinoma in Situ / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000150:complications / Q000473:pathology*; D003218:Condylomata Acuminata / Q000150:complications / Q000473:pathology*; D005199:Fanconi Anemia / Q000150:complications*; D005260:Female; D005833:Genital Neoplasms, Female / Q000150:complications / Q000473:pathology*; D006801:Humans; D009361:Neoplasm Invasiveness; D002583:Uterine Cervical Neoplasms / Q000473:pathology; D014625:Vaginal Neoplasms / Q000473:pathology; D014846:Vulvar Neoplasms / Q000150:complications / Q000473:pathology