title: Structural asymmetries in brains of mice selected for strong lateralization.
abstract: The brains of 18 female mice from two lines selectively bred for lateralization of paw preference were investigated for morphological asymmetries in 5 horizontal sections from mid-dorsoventral planes. Cortical thickness was measured at orbitofrontal, somatosensory and lateral entorhinal regions; volume measures included the hippocampal formation and the striatum. Mice of the strongly lateralized line had stronger asymmetries in 4 of the 5 variables. Discriminant analysis showed that the two mouse lines could be differentiated best by their asymmetries in orbitofrontal cortex and hippocampus (P less than 0.02).
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology*; D002540:Cerebral Cortex / Q000033:anatomy & histology; D003342:Corpus Striatum / Q000033:anatomy & histology; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006624:Hippocampus / Q000033:anatomy & histology; D008032:Limbic System / Q000033:anatomy & histology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D013045:Species Specificity