Hypotensive effects in cats caused by horseradish peroxidase mediated by metabolites of arachidonic acid.
Horseradish peroxidase (HRP) given intravenously was shown to possess a marked hypotensive effect in cats. The effect was not noticeably influenced by antihistamines. Indomethacin and acetylsalicylic acid completely blocked the hypotensive effect of HRP. It is concluded that the effect of HRP on blood pressure is due to stimulation of the synthesis of metabolites of arachidonic acid.
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D002339:Carotid Arteries / Q000187:drug effects / Q000503:physiopathology; D002415:Cats; D006735:Horseradish Peroxidase / Q000494:pharmacology*; D007022:Hypotension / Q000139:chemically induced / Q000503:physiopathology*; D008784:Methysergide / Q000494:pharmacology; D010544:Peroxidases / Q000494:pharmacology*; D013997:Time Factors
D001095:Arachidonic Acids; D006735:Horseradish Peroxidase; D010544:Peroxidases; D008784:Methysergide