Indomethacin potentiates the operant behavior suppressant and rectal temperature lowering effects of low doses of d-amphetamine in rats.
Prostaglandins (PGs) may be important in modulating the actions of d-amphetamine. To test this hypothesis male rats were pretreated with indomethacin to inhibit PG synthesis before d-amphetamine was injected. Indomethacin (5 mg/kg, IP) was found to be without direct effect upon fixed-ratio behavior or rectal temperature, but significantly enhanced the capacity of low doses of d-amphetamine to suppress behavior and lower temperature. These effects were not due to partial food deprivation or to an increase in the concentration of d-amphetamine in brain. It is concluded that one or more of the PGs modulate the central actions of d-amphetamine, perhaps by modifying the release and/or reuptake of catecholamines, or through a postsynaptic action.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D003216:Conditioning, Operant / Q000187:drug effects*; D003913:Dextroamphetamine / Q000378:metabolism / Q000494:pharmacology*; D004357:Drug Synergism; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D051381:Rats
D003913:Dextroamphetamine; D007213:Indomethacin