title: [Significance of serum uric acid determination for the early detection of complications of hypertensive pregnancy in primigravidae].
abstract: In 100 healthy primigravidae the concentration of serum uric acid was examined in a prospective longitudinal study between the 12th and 40th gestational week. Serum uric acid increased continuously and was elevated significantly in 9 women who developed toxaemia of late pregnancy at the 16th, 32nd, and 36th week of pregnancy. If serum concentration are higher than 220 mumol/l or 241 mumol/l in the 32nd gestational week they were considered for a increased risk of developing a hypertensive complication. Sensitivity, specificity and the predictive value of a "positive test" were low in the 16th (22 or 20%) and 32nd (16 or 17%) week of pregnancy. The predictive value of a "negative test" was relative high in the 16th and 32nd week with 93 or 90% respectively 95 or 92%.
mesh_terms: D000293:Adolescent; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D005865:Gestational Age; D006801:Humans; D011225:Pre-Eclampsia / Q000097:blood / Q000175:diagnosis*; D011247:Pregnancy; D012306:Risk; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid
vernacular_title: Zur Bedeutung der Serum-Harnsäurebestimmung für die Früherkennung einer hypertensiven Schwangerschaftskomplikation bei Primigravidae.