[Modification of the FT4-level and the nonspecific peripheral thyroid parameter by heparin].
Heparin produces changes in FT4-levels both in vivo and in vitro as determined by commercial kits. Methods utilising the principle of equilibrium dialysis show significant increases whereas methods using T4-tracer analogue techniques reveal marked decreases in FT4-values. Possible clinical side-effects of heparin administration such as heparin-induced hyperthyroidism and tachyarrhythmias are discussed. The present results confirm the FT4-decreasing effect of in vivo and in vitro administration of heparin with FT4-RIAs based on the tracer analogue technique; however, the unspecific peripheral thyroid parameter of systolic time-intervals did not reveal any tendency towards hyperthyroidism. Also the discrepant results dependent on the method used, indicate that, following heparin administration FT4-levels do not reflect that hormone concentration is relevant to the metabolism of the whole body.
D000328:Adult; D000368:Aged; D003692:Delayed-Action Preparations; D005260:Female; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D006980:Hyperthyroidism / Q000503:physiopathology; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D013599:Systole / Q000187:drug effects*; D013974:Thyroxine / Q000097:blood*
D003692:Delayed-Action Preparations; D006493:Heparin; D013974:Thyroxine
Die Beeinflussung der FT4-Spiegel und eines unspezifischen peripheren Schilddrüsenparameters durch Heparingabe.