Structural restriction in bile acids and non-ionic detergents for promotion of heparin absorption from rat gastro-intestinal tract.
Selected non-ionic surfactants of the polyoxyethylene ether series as well as selected bile acids elicit plasma clearing activity (PC) after oral heparin administration by action on the gastro-intestinal mucosa. Evidence obtained indicates that certain structural characteristics are needed for promoting heparin absorption, since this effect is observed with some but not all non-ionic detergents (cetyl and stearyl ethers but not lauryl) and bile components (deoxycholic, chenodeoxycholic and cholic acids, but not ursodeoxycholic or dehydrocholic acids or lecithin). It is suggested that a specific mechanism of action is involved.
D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology*; D003840:Deoxycholic Acid / Q000494:pharmacology; D003902:Detergents / Q000494:pharmacology*; D005260:Female; D006493:Heparin / Q000097:blood / Q000378:metabolism*; D007408:Intestinal Absorption / Q000187:drug effects*; D008657:Metabolic Clearance Rate; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents / Q000494:pharmacology*
D001647:Bile Acids and Salts; D003902:Detergents; D013501:Surface-Active Agents; D003840:Deoxycholic Acid; D006493:Heparin