title: Mucosal ganglioneuromatosis associated with multiple colonic polyps.
abstract: Two unusual cases of colonic ganglioneuromatosis are described. One case was associated with multiple adenomatous polyps in a 74-year-old man and the second case was associated with juvenile polyps in a 16-year-old boy. To our knowledge this is the first report of colonic mucosal ganglioneuromatosis associated with multiple adenomatous polyps and the second report associated with multiple juvenile polyps. In the first case the ganglioneuromatosis was found in colonic mucosa without adenomatous changes, while in the second case ganglioneuromatosis was found both within normal mucosa and within juvenile polyps. The relationship between mucosal ganglioneuromatosis and multiple colonic polyps remains unclear. Neither patient has yet developed features to suggest either multiple endocrine neoplasia type 2b or von Recklinghausen's disease.
mesh_terms: D000293:Adolescent; D000368:Aged; D003110:Colonic Neoplasms / Q000150:complications / Q000473:pathology*; D003111:Colonic Polyps / Q000150:complications / Q000473:pathology*; D005729:Ganglioneuroma / Q000150:complications / Q000473:pathology*; D006801:Humans; D008297:Male