Dithiocarbamato complexes of technetium: relationship between structure and hepatobiliary excretion.
A series of dithiocarbamato complexes of 99mTc have been prepared and their potential as radiopharmaceuticals investigated in mice. The complexes ranged from non-polar and colloidal to polar and completely soluble. The non-polar complexes were rapidly extracted by the liver and then only slowly excreted while the polar complexes were cleared more slowly from the blood with concurrent rapid hepatobiliary excretion.
D000818:Animals; D001659:Biliary Tract / Q000000981:diagnostic imaging* / Q000378:metabolism; D008099:Liver / Q000000981:diagnostic imaging* / Q000378:metabolism; D008297:Male; D051379:Mice; D011877:Radionuclide Imaging; D013329:Structure-Activity Relationship; D013667:Technetium; D013859:Thiocarbamates; D013997:Time Factors
D013859:Thiocarbamates; D013667:Technetium