[The effect of testosterone propionate, 5 alpha-dihydrotestosterone and 5 alpha-androstan-3 beta, 17 beta-diol on acid phosphatase activity in the prostate of castrated rats].
The acid phosphatase is studied in the prostate gland of rats. It is shown that 10 days after gonadectomy the activity of acid phosphatase lowered considerably. Administration of testosterone propionate or 5 alpha-dihydrotestosterone to castrated animals restored the enzyme activity whereas 5 alpha-androstan-3 beta,17-diol was not effective. Administration of testosterone propionate with one of its metabolites increased the activity of acid phosphatase in the prostate gland, however to a less extent than with the use of the hormone itself. The lowest activity is detected with the simultaneous application of three androgens.
D000135:Acid Phosphatase / Q000378:metabolism*; D015113:Androstane-3,17-diol / Q000494:pharmacology*; D000732:Androstanols / Q000494:pharmacology*; D000818:Animals; D002369:Castration; D013196:Dihydrotestosterone / Q000494:pharmacology*; D004357:Drug Synergism; D004789:Enzyme Activation / Q000187:drug effects; D008297:Male; D011467:Prostate / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000494:pharmacology*
D000732:Androstanols; D013196:Dihydrotestosterone; D015113:Androstane-3,17-diol; D013739:Testosterone; D000135:Acid Phosphatase
Deĭstvie propionata testosterona, 5 alpha-digidrotestosterona i 5 alpha-androstan-3 beta, 17 beta-diola na aktivnost' kisloĭ fosfatazy predstatel'noĭ zhelezy kastrirovannykh krys.