[Comparative evaluation of the lymphocyte blast-transformation reaction induced by various mitogens in the polychemotherapy of patients with breast cancer].
The immunity system condition was studied in 118 patients with breast cancer of stage III who received combination chemotherapy: 91 patients--according to the Cooper scheme and 27 patients--according to CMF scheme. The reaction of lymphocyte blast transformation (LBT) was determined by three mitogens: phytohemagglutinin (PHA "O"), PHA "D" and lipopolysaccharide (LPS). The levels of Ig A, G, M were also determined. A decrease in immunological indices of different degree was observed in all patients. LBT was proved to have a high response to phytohemagglutinin "O" and it is recommended for immunological investigations. No significant changes in the immunological state of LPS were revealed.
D000328:Adult; D000368:Aged; D000917:Antibody Formation; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology; D008213:Lymphocyte Activation; D008875:Middle Aged; D008934:Mitogens / Q000494:pharmacology*; D010835:Phytohemagglutinins / Q000494:pharmacology
D008070:Lipopolysaccharides; D008934:Mitogens; D010835:Phytohemagglutinins
Sravnitel'naia otsenka reaktsii blasttransformatsii limfotsitov pri deĭstvii razlichnykh mitogenov v protsesse polikhimioterapii bol'nykh rakom molochnoĭ zhelezy.