Effect of erythrocyte transfusion on the circulation of Guérin carcinoma-bearing rats.
In Guérin carcinoma-bearing rats during tumour growth cardiac output and blood flow to several organs were increased whereas TPR, vascular resistance of some regions and haematocrit gradually decreased. In response to erythrocyte transfusion the anaemia of tumour-bearing rats was considerably improved or corrected, however, the parameters for systemic and regional circulation were only partially restored. We presume that the circulatory "hyperkinesis" of tumour-bearing rats is partly due to the anaemia but also an unknown factor must be considered. The blood perfusion of the Guérin carcinoma was not affected by the erythrocyte transfusion thus it is feasible that the tumour vasculature is maximally dilated even with a normal haematocrit of the host.
D000740:Anemia / Q000209:etiology / Q000503:physiopathology; D000818:Animals; D001775:Blood Circulation; D001803:Blood Transfusion; D002277:Carcinoma / Q000150:complications; D002302:Cardiac Output; D017707:Erythrocyte Transfusion; D006400:Hematocrit; D008297:Male; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000503:physiopathology*; D051381:Rats; D012039:Regional Blood Flow; D014655:Vascular Resistance