Slow saccades and hypometria in anticonvulsant toxicity.
We report a patient with abnormal saccades in association with anticonvulsant toxicity (phenytoin 27.5 micrograms/ml, phenobarbital 18.8 micrograms/ml). The patient looked toward visual targets either with multiple, small, hypometric saccades or with single slow saccades. These abnormalities resolved when anticonvulsant levels returned to therapeutic range. Thus, slow saccades may be clinical evidence of anticonvulsant toxicity.
D001921:Brain / Q000187:drug effects; D005128:Eye Diseases / Q000139:chemically induced; D005133:Eye Movements / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced; D010634:Phenobarbital / Q000009:adverse effects*; D010672:Phenytoin / Q000009:adverse effects*
D010672:Phenytoin; D010634:Phenobarbital