title: [Use of tamoxifen in patients with disseminated and local breast neoplasms].
abstract: The efficacy of tamoxifen treatment was studied in 46 postmenopausal patients with localized and disseminated breast cancer. Objective remissions were observed in 47.8, stabilization of tumor process-in 21.7%, mostly in cases of metastasis into the skin, subcutaneous fat, lymph nodes, pleura and bones. Tamoxifen proved sufficiently effective both in primary treatment and as a measure taken when the effect of a specific therapy (radiation, cytostatic or hormonal) was over. Side-effects were slight and were registered in 19.6%.
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003556:Cystitis / Q000139:chemically induced; D005260:Female; D006801:Humans; D008593:Menopause; D008796:Metrorrhagia / Q000139:chemically induced; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced; D009362:Neoplasm Metastasis; D013629:Tamoxifen / Q000009:adverse effects / Q000627:therapeutic use*; D013921:Thrombocytopenia / Q000139:chemically induced
chemical_list: D013629:Tamoxifen
vernacular_title: Primenenie tamoksifena pri lechenii bol'nykh disseminirovannymi i mestno-rasprostranennymi formami raka molochnoĭ zhelezy.