Distribution and elimination of polymethyl methacrylate nanoparticles after peroral administration to rats.
Polymethyl [1-14C]methacrylate nanoparticles were administered orally to bile cannulated rats. Ten to fifteen percent of the administered radioactivity was absorbed and found in the bile and urine. Within 48 h, 94-97% of the absorbed radioactivity had been eliminated from the body. After 8 d, the highest residual radioactivity was found in the bone marrow, fatty renal tissue, stomach, liver, and lymph nodes.
D000284:Administration, Oral; D000818:Animals; D001646:Bile / Q000378:metabolism; D005260:Female; D007700:Kinetics; D008297:Male; D008768:Methylmethacrylates / Q000378:metabolism*; D008863:Microspheres; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D008768:Methylmethacrylates