[Rectal adenocarcinoma in adults under 35 years of age. Apropos of 37 cases].
Minimum follow up of 37 cases treated at the "Institut Gustave-Roussy (IGR)" over the last 10 years has been for more than 23 months. Twenty-three of these patients had been treated entirely by the IGR using surgery and radiotherapy (45 to 60 Gy). Excision was curative in 13 cases and palliative in 10. Several conclusions can be drawn: The relative frequency in inhabitants of mediterranean countries (particularly North Africa and Italy where this cancer is respectively 15 ans 17 times more frequent than in young Frenchmen) and in women; the absence of obvious predisposing factors; the frequency of mucosal colloid forms (57%), and the extent of the lesion at diagnosis (60%, of Dukes C2 and 20% of Dukes D) even when there was no delay between first symptoms and diagnosis; and the 2-year survival (45%) in the patients treated in the IGR alone, whereas it is 75% for the 285 patients over 35 years of age. Early diagnosis, including in young adults, is essential, as well as immediate radical surgery and radiotherapy.
D000230:Adenocarcinoma / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D012004:Rectal Neoplasms / Q000175:diagnosis* / Q000453:epidemiology / Q000628:therapy; D012189:Retrospective Studies
Adénocarcinomes rectaux chez l'adulte de moins de 35 ans. A propos de 37 observations.