title: [Role of endorphins in the function of the lower urinary tract].
abstract: In order to investigate the influence of the endorphins on lower urinary tract function we antagonized the endogenous opiates with naloxone. We performed urodynamic examination in 17 incontinent women, administered intravenously 0.4 mg naloxone, and repeated the urodynamic examination. Bladder volume and pressure were not influenced by naloxone; the maximum urethral pressure showed a slight and urethral closure pressure a significant rise after naloxone treatment. Contrary to other authors, our results do not support a role of endorphins in lower urinary tract function.
mesh_terms: D000328:Adult; D004723:Endorphins / Q000037:antagonists & inhibitors / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000494:pharmacology; D011312:Pressure; D014521:Urethra / Q000187:drug effects; D001743:Urinary Bladder / Q000187:drug effects; D014549:Urinary Incontinence / Q000503:physiopathology; D014563:Urodynamics / Q000187:drug effects
chemical_list: D004723:Endorphins; D009270:Naloxone
vernacular_title: Rolle der Endorphine für die Funktion des unteren Harntrakts.