Effects of early tamoxifen treatment on hormonal content of 15-day quail embryo gonads.
An early treatment of quail eggs with an antiestrogen (Tamoxifen = TAM) modifies the female gonads morphologically. In the left ovary, the proliferation of the germinal epithelium and formation of a cortex is markedly inhibited, while the medulla on both sides becomes more developed and keeps a cordal organization. The effects of TAM on the hormonal potentialities of 15-day embryo gonads have been investigated by radioimmunoassay. The data have been compared with those of normal gonads. The results indicate that the TAM treatment does not mainly modify the hormonal levels and patterns in the gonads of both sexes and does not inhibit the function of the hypothalamo-hypophyseal-gonadal axis. The reduced cortical development is thus not linked to an estrogen decrease but to competitive effects on receptors at the level of this tissue.
D000818:Animals; D003370:Coturnix / Q000196:embryology*; D004958:Estradiol / Q000378:metabolism; D004970:Estrone / Q000378:metabolism; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D008297:Male; D010053:Ovary / Q000187:drug effects / Q000196:embryology* / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011784:Quail / Q000196:embryology*; D013629:Tamoxifen / Q000494:pharmacology*; D013737:Testis / Q000187:drug effects / Q000196:embryology* / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism
D012739:Gonadal Steroid Hormones; D011506:Proteins; D013629:Tamoxifen; D004970:Estrone; D013739:Testosterone; D004958:Estradiol