title: Effect of amphotericin B and gestational age on sodium transport across the rat visceral yolk sac placenta in vitro.
abstract: The transport properties of the rat visceral yolk sac placenta from Days 14.5 to 18.5 of gestation were studied in vitro. All tissues had a positive potential difference, fetal side relative to maternal side, and showed net Na transport towards the fetus. Basal short-circuit current and net Na flux increased rapidly with gestational age over the period studied. Amphotericin B applied to the maternal surface of the yolk sac stimulated current and net Na flux, indicating that the apical membrane Na permeability limited transport and revealing a reserve capacity for transport. Contrary to their basal values, current and Na flux following treatment with amphotericin were independent of gestational age.
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D004594:Electrophysiology; D005260:Female; D005865:Gestational Age; D066298:In Vitro Techniques; D011247:Pregnancy; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D015017:Yolk Sac / Q000378:metabolism*
chemical_list: D000666:Amphotericin B; D012964:Sodium