title: Calcitonin in a chronoepidemiologic perspective.
abstract: Calcitonin seasonal (circannual) variations in apparently healthy women and in women suffering from breast cancer in different evolutive-TNM-stage, were studied. Annual values are higher in patients with breast cancer, but there is no correlation with metastases. A significant calcitonin circannual rhythm with acrophase in winter was detectable in controls but not in breast cancer patients. The circannual rhythm obliteration could be a predictive signal of disease and not only metastatic disease.
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001943:Breast Neoplasms / Q000097:blood* / Q000473:pathology; D002116:Calcitonin / Q000097:blood*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008875:Middle Aged; D012621:Seasons
chemical_list: D002116:Calcitonin