title: [Nitrogenous triterpene derivatives. 9. 3-Acetyloleanol acid-28-amides and their antiulcer effect].
abstract: The authors report on the synthesis of 3-acetyloleanol acid-28-amids 10, 12-16, 19, 20, 22 and 24. The amids 16 (30%) and 24 (37%) were of most favourable inhibiting effect on the formation of gastric ulcera following pylorus ligature. The ulcer formation caused by p. o. administration of indometacin (Metindol) was in the main reduced by the amids 15 (60%), 16 (34%), and 24 (46%). With both the methods the effect of carbenoxolon sodium amounts to 40 or 50%. In ulcera induced by indometacin, the 11- and 3-oxooleanol acid derivates 12 and 18 revealed stimulating characteristics.
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D007213:Indomethacin; D008297:Male; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D014315:Triterpenes / Q000138:chemical synthesis*
chemical_list: D000897:Anti-Ulcer Agents; D014315:Triterpenes; D007213:Indomethacin
vernacular_title: Stickstoffhaltige Triterpenderivate. 9. Mitteilung: 3-Acetyloleanolsäure-28-amide und ihre antiulceröse Wirkung.