Guanethidine sympathectomy does not prevent meal-induced increases in the weight or oxygen consumption of brown fat.
The interscapular brown adipose tissue (BAT) of adult rats that were neonatally sympathectomized with guanethidine (GUA) consumed less oxygen but weighed the same as BAT from intact controls. In response to a 2-hr mixed-constituent meal, BAT from sympathectomized and control rats showed similar increases in oxygen uptake and weight. These data suggest that some functions of BAT can be maintained even without sympathetic stimulation.
D002001:Adipose Tissue, Brown / Q000033:anatomy & histology / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001833:Body Temperature Regulation; D004435:Eating; D006145:Guanethidine; D008297:Male; D009929:Organ Size; D010101:Oxygen Consumption; D051381:Rats; D013563:Sympathectomy, Chemical; D013564:Sympathetic Nervous System / Q000502:physiology*
D006145:Guanethidine