Adverse toxic reaction to aqueous procaine penicillin G.
Aqueous procaine penicillin G therapy is frequently used in ambulatory care settings and clinicians have long been alerted to the potential allergic reactions that may occur with this therapy; however, the nonallergic toxic reaction has not been as widely publicized. A possible psychotic-like, pseudoanaphylactic reaction may occur within 60 seconds following an injection of aqueous procaine penicillin G. Two case reports and a review of the literature will be presented to alert clinicians to this reaction. Suggestions for management will also be offered.
D000293:Adolescent; D000328:Adult; D000707:Anaphylaxis / Q000097:blood / Q000139:chemically induced* / Q000517:prevention & control / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D009722:Nurse Practitioners; D010400:Penicillin G / Q000009:adverse effects*; D010402:Penicillin G Procaine / Q000008:administration & dosage / Q000009:adverse effects*; D011343:Procaine / Q000097:blood; D011605:Psychoses, Substance-Induced / Q000097:blood / Q000209:etiology* / Q000517:prevention & control / Q000628:therapy
D010402:Penicillin G Procaine; D011343:Procaine; D010400:Penicillin G