[Electroencephalogram changes in animals with neurosis as a correlate of metabolic brain disorders].
Experiments were made to correlate changes in bioelectrical activity of the brain of different animals (rats, cats, monkeys) with neurosis and its treatment to the time course of the activity of ATPase, one of the most important enzymes of energy metabolism. It was demonstrated that the electroencephalogram (EEG) taken during neurosis is marked by an increase in the total energy of quick-wave components and reduction in the total energy of slow-wave ones in all the structures under study, by the deterioration of the rhythm change response. These changes corresponded with the inhibited activity of brain Na, K-ATPase, particularly of Mg-ATPase. The EEG returned to normal and ATPases were activated after nikogamol injections.
D000818:Animals; D001921:Brain / Q000378:metabolism; D001928:Brain Diseases, Metabolic / Q000503:physiopathology*; D002415:Cats; D004562:Electrocardiography; D004734:Energy Metabolism / Q000187:drug effects; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D009474:Neurons / Q000378:metabolism; D009497:Neurotic Disorders / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology*; D009539:Nicotinic Acids / Q000008:administration & dosage; D010775:Photic Stimulation; D051381:Rats; D012149:Restraint, Physical; D013963:Thyroid Hormones / Q000494:pharmacology
D009539:Nicotinic Acids; D013963:Thyroid Hormones; C004227:thyroidin; C041555:nikogamol
Izmeneniia élektroéntsefalogrammy zhivotnykh pri nevroze kak korrelat metabolicheskikh narusheniĭ mozga.