[Biopsy data on the ultrastructural changes in the cerebral cortex in Vilyui encephalomyelitis].
Biopsies from the cortex of the right frontal lobe of 3 patients with chronic Vilyui encephalomyelitis were examined light- and electron microscopically. The characteristic degenerative changes in the gangliocytes and especially in the nerve fibers are typical for this disease; particularly severe lesions were found in the myelin sheaths and to a lesser extent in the axons. Myelin sheaths lamella, external mitochondrial membranes and other organelles showed osmiophilic degeneration with their destruction and release of peculiar crystal-like formations having an elective localization in the processes cytoplasm and not in the perikaryon. Abnormal chromatin agglomeration, increase in size and ectopy of nucleoli were observed.
D002908:Chronic Disease; D003593:Cytoplasm / Q000648:ultrastructure; D004679:Encephalomyelitis / Q000473:pathology*; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D008854:Microscopy, Electron; D009186:Myelin Sheath / Q000648:ultrastructure*; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure; D009457:Neuroglia / Q000648:ultrastructure*
Ul'trastrukturnye izmeneniia kory golovnogo mozga pri Viliuĭskom entsefalomielite po dannym biopsii.