Synthesis of N1- and N3-glycosyl pyrimidines from protected pyrimidines and halo sugars in the presence of tert-amine.
The reaction of N1- and N3-(octylthio)carbonyl pyrimidines with acylglycosyl halides in the presence of tert-amine affords fully protected nucleosides with (N1-C1') and (N3-C1') glycosidic linkages in good yields. The (octylthio)carbonyl and acyl groups are removed stepwise or at once.
D007202:Indicators and Reagents; D011742:Pyrimidine Nucleotides / Q000138:chemical synthesis*; D011743:Pyrimidines / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; D011742:Pyrimidine Nucleotides; D011743:Pyrimidines