title: Disulfiram is protective against postischemic cell death in the liver.
abstract: The effect of the scavenger compound disulfiram (Antabus) on postischemic cell injury was investigated. Rats were subjected to 90 min of liver ischemia and 3 h of reperfusion. The extent of cell injury was evaluated morphologically by a dye exclusion test and a histochemical stain for calcium. It was found that pretreatment with disulfiram significantly reduced the number of injured cells compared to untreated controls.
mesh_terms: D000818:Animals; D002452:Cell Count; D002470:Cell Survival / Q000187:drug effects; D004221:Disulfiram / Q000494:pharmacology*; D007511:Ischemia; D008099:Liver / Q000098:blood supply / Q000166:cytology*; D008297:Male; D008856:Microscopy, Fluorescence; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D004221:Disulfiram