title: [The effect of nitrofurans on the membrane apparatus of coccal bacteria].
abstract: Secondary membrane effects on the membrane apparatus of coccus bacteria were being studied. Cultivation of Micrococcus lysodeikticus and Staphylococcus aureus cells on subbacteriostatic concentrations of nitrofurans results in a lower biosynthesis of many membrane proteins, as well as in inhibiting the activity of respiratory enzymes, i. e. the specific concentration of cytochromes and specific activity of NADH-, malate-, lactate oxidases and some reductases drop. Some cytological changes were revealed, when cells were grown on solafur, furazolidone, and furacriline.
mesh_terms: D001426:Bacterial Proteins / Q000037:antagonists & inhibitors; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D005661:Furagin / Q000494:pharmacology; D005664:Furazolidone / Q000494:pharmacology; D008565:Membrane Proteins / Q000037:antagonists & inhibitors; D008837:Micrococcus / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D008854:Microscopy, Electron; D009581:Nitrofurans / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D014230:Triazoles / Q000494:pharmacology
chemical_list: D001426:Bacterial Proteins; D008565:Membrane Proteins; D009581:Nitrofurans; D014230:Triazoles; C007793:furacrylan; D005664:Furazolidone; D005661:Furagin
vernacular_title: Deĭstvie nitrofuranov na membrannyĭ apparat bakteriĭ kokkovoĭ gruppy.