Testosterone and tolerance in rat vas deferens.
Testosterone is able to inhibit the development of tolerance in the smooth muscle of the rat vas deferens. Cycloheximide and actinomycin D also inhibit the tolerance to morphine and ethanol in smooth muscle of rat vas deferens. The toxic effect of cycloheximide and actinomycin D do not play roles in the inhibition of tolerance. The physiological responses of vas deferens to norepinephrine are not altered by cycloheximide and actinomycin D.
D000818:Animals; D002369:Castration; D003513:Cycloheximide / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000494:pharmacology*; D014649:Vas Deferens / Q000187:drug effects*
D003609:Dactinomycin; D000431:Ethanol; D013739:Testosterone; D009020:Morphine; D003513:Cycloheximide; D009638:Norepinephrine