[A microanalytical gas liquid chromatography method with a nitrogen-phosphorus detector in the assay of various psychotropic drugs of tricyclic structure and of their N-demethylated metabolites].
Nanogram amounts of chlorimipramine, chlorpromazine and their Nor1- and Nor2-metabolites were detected in plasma by GLC with nitrogen-sensitive detection. Two extraction procedures were compared. The use of Sep Pak C18 cartridges produced a higher degree of accuracy and precision with significant time and materials saving, as compared to the use of organic solvents in a three steps extraction procedure.
D002746:Chlorpromazine / Q000031:analogs & derivatives* / Q000097:blood*; D002849:Chromatography, Gas / Q000379:methods; D002997:Clomipramine / Q000031:analogs & derivatives* / Q000097:blood*; D006801:Humans; D007099:Imipramine; D008832:Microchemistry / Q000379:methods; D009584:Nitrogen; D010758:Phosphorus
D010758:Phosphorus; D009584:Nitrogen; D002997:Clomipramine; C029699:norchlorpromazine; D007099:Imipramine; D002746:Chlorpromazine
Metodo microanalitico GLC con un rivelatore azoto-fosforo per il dosaggio di alcuni farmaci psicotropi a struttura triciclica e dei loro metaboliti N-demetilati.