Urinary MHPG is not a good predictor of antidepressive drug response.
The final results of treatment with 4 antidepressants (amitriptyline, imipramine, chlorimipramine and mianserine) in 80 patients with endogenous depression were analyzed with respect to their pre-treatment levels of urinary MHPG. The analysis revealed that MHPG measurements were of no practical value in predicting individual response to antidepressants.
D000328:Adult; D000368:Aged; D000639:Amitriptyline / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use*; D002997:Clomipramine / Q000627:therapeutic use; D003866:Depressive Disorder / Q000188:drug therapy* / Q000652:urine; D005260:Female; D006018:Glycols / Q000652:urine*; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D008803:Mianserin / Q000627:therapeutic use; D008875:Middle Aged; D011379:Prognosis; D011569:Psychiatric Status Rating Scales
D000928:Antidepressive Agents; D006018:Glycols; D000639:Amitriptyline; D008803:Mianserin; D008734:Methoxyhydroxyphenylglycol; D002997:Clomipramine; D007099:Imipramine