Role of uteroferrin in placental iron transport: effect of maternal iron treatment on fetal iron and uteroferrin content and neonatal hemoglobin.
Uteroferrin, an Fe-containing, progesterone-induced glycoprotein is involved in maternal to fetal Fe transport in swine. These studies examined the effect of im Fe injection of dam on conceptus and piglet Fe stores. In Exp. I, eight gilts were bred and assigned to either treatment I (no Fe injections) or treatment II (total of 22 mg iron-dextran/kg body weight on d 40, 45, 50, 55 and 60 of gestation) and hysterectomized on d 90 to determine whether Fe injections increased Fe stores in the conceptus. Total Fe in allantoic fluid (P less than .10) as well as uteroferrin concentration (P less than .05) and total uteroferrin (P less than .05) in placentae were greater for gilts in treatment II. In Exp. II, 19 cross-bred sows were bred and assigned to treatments I and II (d 40, 50 and 60 of gestation), as in Exp. I, and treatment III (total of 22 mg iron-dextran/kg body weight on d 90, 100 and 110 of gestation) to determine effects of treatment on hemoglobin (Hb) values of the piglets at 8 +/- 1 h and d 4 postpartum. Piglets from treatment II had higher (P less than .01) Hb at 8 +/- 1 h, but not on d 4 postpartum. Experiment III was a replication of Exp. II except that Hb values were determined at 8 +/- 1 h, d 4 and d 7 postpartum. On d 7, piglets from treatment II had higher (P less than .05) Hb, but differences at 8 +/- 1 h and d 4 were not significant (P greater than .10).(ABSTRACT TRUNCATED AT 250 WORDS)
D000135:Acid Phosphatase / Q000378:metabolism; D000482:Allantois; D000818:Animals; D000831:Animals, Newborn / Q000097:blood; D001693:Biological Transport, Active; D001826:Body Fluids / Q000378:metabolism; D005260:Female; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D007505:Iron-Dextran Complex / Q000494:pharmacology*; D007527:Isoenzymes; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D008667:Metalloproteins / Q000378:metabolism / Q000502:physiology*; D010920:Placenta / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D013552:Swine / Q000502:physiology*; D000071681:Tartrate-Resistant Acid Phosphatase
D006454:Hemoglobins; D007527:Isoenzymes; D008667:Metalloproteins; D007505:Iron-Dextran Complex; D007501:Iron; D000135:Acid Phosphatase; D000071681:Tartrate-Resistant Acid Phosphatase