title: [Precocious pseudopuberty secondary to granulosa cell tumor].
abstract: A case report of pseudoprecocity secondary to a unilateral ovarian tumor of granulosa cells is presented in a 13 month old female. Clinical manifestations appeared at two months of age as unilateral enlargement of the breast, development of pubic hair and vaginal discharge. Plasma estrogen levels were elevated, whereas there was no response of FSH and LH to LH-RH stimulation. The absence of a palpable abdominal mass and a normal ultrasound examination of the abdomen must be pointed out in our case. The suspected clinical and laboratory diagnosis was later confirmed by surgical abdominal examination and ovarian histopathology study. With the exception of a minimal breast enlargement which persists at two years of age, all other signs of pseudoprecocity have disappeared after the surgical removal of the neoplasm. The importance of surgical abdominal examination must be pointed out as a diagnostic method when clinical and laboratory findings suggest an ovarian tumor inspite of normal abdominal palpation, ultrasound and roentgenology.
mesh_terms: D005260:Female; D006106:Granulosa Cell Tumor / Q000150:complications* / Q000473:pathology; D006801:Humans; D007223:Infant; D010051:Ovarian Neoplasms / Q000150:complications* / Q000473:pathology; D011629:Puberty, Precocious / Q000209:etiology*
vernacular_title: Pseudopubertad precoz secundaria a tumor de la granulosa.