[Effect of whole-body irradiation of females on pregnancy and postnatal development of the offspring].
In 218 primigravida rats of Wistar strain with body mass 200-250 g radiosensitivity during the whole period of pregnancy has been studied after a single total gamma-radiation with 60Co given in LD50 2.0 Gy. The multifactor analysis includes: dynamics of the body mass of the pregnant rats, ability to implantation and pregnancy, duration of pregnancy, number of births that failed, body mass loss during delivery, death of the embryos during the antenatal period, number of viable offsprings, dynamics of body mass in the offsprings and their viability during 30 days after birth, time for covering with fur and eyes opening, developmental anomalies etc. Quantitative and qualitative postradiative disorders of the intrauterine and postnatal development of the offsprings are described. The most sensitive days of pregnancy are revealed (the 1st--3d and the 9th--11th days).
D000016:Abnormalities, Radiation-Induced / Q000209:etiology; D000818:Animals; D001835:Body Weight / Q000528:radiation effects; D003037:Cobalt Radioisotopes / Q000009:adverse effects; D010064:Embryo Implantation / Q000528:radiation effects; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005328:Fetal Viability / Q000528:radiation effects; D005333:Fetus / Q000528:radiation effects*; D008297:Male; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000528:radiation effects*; D011836:Radiation Tolerance; D051381:Rats; D011919:Rats, Inbred Strains
D003037:Cobalt Radioisotopes
Vliianie obshchego gamma-oblucheniia samok na beremennost' i postnatal'noe razvitie potomstva.