The behavior of neutral amine oxime chelates labelled with Tc at tracer level.
Neutral 99mTc-chelates were formed with propylene amine oxime, 3,3'-(1,3-propanediyldiimino)bis-(3-methyl-2-butanone)-dioxime and other PnAO analogues. Even though the other amine oxime ligands form neutral chelates with 99mTc, the stability, lipophilic and the brain uptake characteristics are less desirable than [99mTc]-PnAO. These results demonstrate that slight modifications in the amine oxime ligand backbone produces significant effects on the chemical and biological behavior of the [99mTc]dioxime chelates.
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging*; D002614:Chelating Agents; D010091:Oximes / Q000378:metabolism; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D013667:Technetium / Q000378:metabolism; D014018:Tissue Distribution
D002614:Chelating Agents; D010091:Oximes; D013667:Technetium