title: Effect of pretreatment with carbimazole on early outcome following radio-iodine (131I) therapy.
abstract: Of a group of 55 thyrotoxic patients given therapeutic radio-iodine (131I), 24 were made euthyroid with carbimazole before 131I: the remainder were given 131I alone. Carbimazole was discontinued 5 days before 131I was administered. By 3 months after 131I treatment there was a greater incidence of hypothyroidism in the group given 131I alone (42% vs 25%), but a lower incidence of persistent thyrotoxicosis (16% vs 46%), (P less than 0.05). One year after treatment a similar proportion of each group had persistent thyrotoxicosis (21% vs 23%), but there remained a lower incidence of hypothyroidism in the group pretreated with carbimazole (25% vs 45%). It is suggested that pretreatment with carbimazole reduces the degree of radiation induced thyroid damage.
mesh_terms: D000368:Aged; D002231:Carbimazole / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy* / Q000532:radiotherapy; D007037:Hypothyroidism / Q000209:etiology; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011837:Radiation-Protective Agents / Q000627:therapeutic use; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000528:radiation effects; D013997:Time Factors
chemical_list: D007457:Iodine Radioisotopes; D011837:Radiation-Protective Agents; D002231:Carbimazole