title: Antidepressant tachyphylaxis.
abstract: We report eleven patients in whom tachyphylaxis to antidepressants, lithium or ECT occurred. These cases are a small sample of patients we have encountered in whom an initial good response to mood regulating drugs was not sustained. We suspect that systematic studies would reveal that tachyphylaxis is a common phenomenon with antidepressant therapies.
mesh_terms: D000328:Adult; D000804:Angiotensin II / Q000494:pharmacology; D000928:Antidepressive Agents / Q000494:pharmacology*; D002118:Calcium / Q000502:physiology; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009712:Nucleotides, Cyclic / Q000502:physiology; D011453:Prostaglandins / Q000502:physiology; D013564:Sympathetic Nervous System / Q000502:physiology; D013618:Tachyphylaxis; D013696:Temperature
chemical_list: D000928:Antidepressive Agents; D008996:Monoamine Oxidase Inhibitors; D009712:Nucleotides, Cyclic; D011453:Prostaglandins; D000804:Angiotensin II; D002118:Calcium