title: Drug-induced repetitive sharp EEG discharges in multi-infarct dementia.
abstract: Elderly patients are usually more susceptible to and more often show adverse drug reactions. Repetitive sharp EEG transients, reversible upon withdrawal of neuroleptic drugs, are reported in clinical multi-infarct dementia. The predisposing and eliciting mechanisms underlying the occurrence of this neurotoxic electroclinical syndrome are discussed. Our observations suggest a relation between repetitive sharp EEG discharges and dysfunction of adrenergic transmission.
mesh_terms: D000368:Aged; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D002544:Cerebral Infarction / Q000150:complications / Q000503:physiopathology*; D003704:Dementia / Q000150:complications / Q000503:physiopathology*; D004569:Electroencephalography; D006801:Humans; D008297:Male; D008728:Methotrimeprazine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D008728:Methotrimeprazine