title: Visual evoked potentials altered by serum IgG of patients with multiple sclerosis.
abstract: Immunoglobulin G, isolated from serum of patients with multiple sclerosis was repeatedly injected into guinea pigs and serial visual evoked potentials were recorded. Latency changes indicated a reversible delay in conduction velocity in the central visual pathways. This finding suggests that some component of immunoglobulin plays a role in the pathogenesis of multiple sclerosis.
mesh_terms: D000818:Animals; D001921:Brain / Q000503:physiopathology; D005074:Evoked Potentials, Visual; D006168:Guinea Pigs; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D009103:Multiple Sclerosis / Q000276:immunology* / Q000503:physiopathology; D014795:Visual Pathways / Q000276:immunology
chemical_list: D007074:Immunoglobulin G