title: Human maternal-fetal lactate relationships.
abstract: This study attempts to determine the major source of lactate in the normal and in the depressed human fetus, in order to assess the applicability of fetal blood lactate measurement for the evaluation of fetal stress during labor. We obtained umbilical arterial and venous blood samples at delivery in 132 liveborn infants, together with simultaneous maternal radial arterial samples. All samples were analyzed immediately for pH, blood gases, and lactate. In vigorous newborns (1-minute Apgar score greater than or equal to 7), umbilical arterial and venous lactate levels were lowest with elective cesarean section done before the onset of labor, higher with cesarean section performed during labor, and highest at the time of vaginal delivery (p less than 0.001, Tab. I). Fetal lactate levels were also significantly higher than maternal levels in vigorous newborns (p less than 0.01), the lactate difference between umbilical artery and maternal artery being lowest with elective cesarean section, higher with cesarean section performed during labor, and highest with vaginal delivery (p less than 0.02, Tab. II). Depressed newborns (1-minute Apgar score less than 7) had higher umbilical lactates and higher fetal-maternal lactate differences than vigorous newborns (p less than 0.01, Tab. III). Our results indicate that the blood lactate levels in both mother and fetus increase with labor and reach their highest values at the time of vaginal delivery. The lactate levels are highest in the umbilical artery, lower in the umbilical vein, and lowest in the maternal artery before the onset of labor.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D001158:Arteries; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D006801:Humans; D007773:Lactates / Q000097:blood*; D019344:Lactic Acid; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D014469:Umbilical Arteries; D014471:Umbilical Veins
chemical_list: D007773:Lactates; D019344:Lactic Acid