title: A syndrome of hepatogenous photosensitisation, resembling geeldikkop, in sheep grazing Tribulus terrestris.
abstract: Two outbreaks of photosensitivity disease occurred in weaner sheep in south western New South Wales during early autumn 1982. In each instance there was a history of access to the annual herb, Tribulus terrestris and both the clinical and pathological findings were consistent with geeldikkop, a major disease in the Republic of South Africa. The prevalence rates of clinical cases were 21 and 37%, while the case fatality rates approached 70%. Clinical signs were dominated by jaundice and photosensitisation. Ochre and khaki discolouration were present in the liver and kidneys, respectively. Histopathologically, the most characteristic lesion was the presence of acicular, cholesterol-like clefts in the lumens of bile ducts and in the cytoplasm of hepatocytes and Kupffer cells. Similar structures were also evident in the lumens of nephrons in association with segmental hyperplasia of the neighbouring tubular epithelium. The possible pathogenesis of the hepatogenous photosensitisation and its resemblance to geeldikkop are discussed.
mesh_terms: D000818:Animals; D001315:Australia; D004196:Disease Outbreaks / Q000662:veterinary*; D005260:Female; D008297:Male; D010787:Photosensitivity Disorders / Q000453:epidemiology / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D010939:Plant Poisoning / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000453:epidemiology* / Q000209:etiology / Q000473:pathology; D013577:Syndrome / Q000662:veterinary