Pharmacological studies of a series of dermorphin related pentapeptides.
Pharmacological activity in vitro and in vivo of 17 pentapeptide analogs of dermorphin (opioid heptapeptide) are reported. Substitutions of the Tyr5 residue afford dermorphin related pentapeptides which are likely to discriminate between mu- and delta-receptors.
D000818:Animals; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology*; D018847:Opioid Peptides; D011930:Reaction Time / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects
D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin