Similar effects of various low-molecular-weight enzyme inhibitors on enzyme networks in dystrophic mice.
We compared the therapeutic effects of various low-molecular-weight enzyme inhibitors on dystrophic mice. Leupeptin, bestatin, forphenicinol and forphenicine significantly affected the enzymatic activities in the dystrophic muscles. The pattern of enzymatic changes in the muscles of forelimb and hindlimb caused by these inhibitors were similar in spite of the variety of their inhibitory spectra in vitro. However, comparing the pattern of enzymatic changes in spleen, forphenicinol differed from the other inhibitors tested. This may be related to the peculiar effects of this inhibitor on immunologically responsive cells.
D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors; D000626:Aminopeptidases / Q000037:antagonists & inhibitors; D000818:Animals; D004950:Esterases / Q000037:antagonists & inhibitors; D005552:Forelimb; D043384:Glutamyl Aminopeptidase; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006614:Hindlimb; D007930:Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007931:Leucyl Aminopeptidase / Q000037:antagonists & inhibitors; D007976:Leupeptins / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D008970:Molecular Weight; D009132:Muscles / Q000201:enzymology; D009137:Muscular Dystrophy, Animal / Q000201:enzymology*; D009842:Oligopeptides / Q000494:pharmacology*; D013154:Spleen / Q000201:enzymology
D007976:Leupeptins; D009842:Oligopeptides; C016464:forphenicine; C035946:forphenicinol; D004950:Esterases; D000469:Alkaline Phosphatase; D000626:Aminopeptidases; D007931:Leucyl Aminopeptidase; D043384:Glutamyl Aminopeptidase; D007930:Leucine; C012211:ubenimex; C032854:leupeptin; D005998:Glycine