Nifedipine in scleroderma ulcerations.
Cutaneous ulcerations may be due to a variety of causes, including vasculitis, infections, arterial insufficiency, and microvascular damage. The net effect is diminished blood flow to the skin. Nifedipine, a calcium antagonist, has been shown to improve cutaneous blood flow and to alleviate reactive vasospastic ischemia (Raynaud's phenomenon). The authors report an ischemic ulcer of scleroderma showing visible improvement with nifedipine therapy.
D000368:Aged; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000188:drug therapy* / Q000209:etiology; D009543:Nifedipine / Q000627:therapeutic use*; D012595:Scleroderma, Systemic / Q000150:complications*; D013997:Time Factors
D009543:Nifedipine