[Effects of trimebutine maleate (TM-906) on the gastrointestinal motility in anesthetized dogs].
Effects of trimebutine maleate (TM-906) on the spontaneous motility of the gastrointestinal tracts were investigated in anesthetized dogs by means of force transducers. TM-906, administrated intravenously or intraduodenally, produced an inhibition followed by a potentiation of the spontaneous motility in the stomach, and caused a potentiation of the spontaneous motility in the duodenum, jejunum, ileum and colon. These effects of TM-906 were observed also in the vagotomized dogs as in the intact dogs. From these results, it is suggested that TM-906 modulates the spontaneous motility of the gastrointestinal tracts primarily through the peripheral mechanism.
D000758:Anesthesia; D000818:Animals; D001565:Benzoates / Q000494:pharmacology*; D004285:Dogs; D005769:Gastrointestinal Motility / Q000187:drug effects*; D008297:Male; D013268:Stimulation, Chemical; D014287:Trimebutine / Q000494:pharmacology*; D014628:Vagotomy
D001565:Benzoates; D014287:Trimebutine