Rifampicin-induced chromatid exchanges in Sarcoma-180 mouse ascites cells.
Sarcoma-180 ascites tumour-bearing male mice were injected i.p. with single dose of 0.5, 2.5, 5 mg/kg body wt. of rifampicin. Cells were sampled for mitotic chromosome analysis 4, 16 or 24 h after treatment. The maximal yield of chromatid-type aberrations induced was found 24 h after treatment with 5 mg/kg of rifampicin. More than 60% of the cells carried at least one chromatid exchange. The majority of these were exchanges derived from breaks in the centromeric heterochromatin.
D000818:Animals; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D008677:Metaphase / Q000187:drug effects; D051379:Mice; D012293:Rifampin / Q000633:toxicity*; D012510:Sarcoma 180 / Q000235:genetics / Q000473:pathology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D012293:Rifampin