A technique for monitoring respiratory responses in guinea pigs.
A piezoelectric crystal was used to detect respiration rates and pulmonary retractions of guinea pigs in response to intratracheal administration of histamine. Voltage output from the crystal was displayed on a recorder for visual processing and interfaced to a microcomputer for automatic data processing. Using intratracheal instillation of histamine, this system accurately reproduced the visual observations of respiratory responses in guinea pigs.
D000818:Animals; D000830:Animals, Laboratory; D001249:Asthma / Q000503:physiopathology; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs / Q000502:physiology*; D006632:Histamine / Q000008:administration & dosage / Q000494:pharmacology; D008838:Microcomputers; D012119:Respiration / Q000187:drug effects*; D012129:Respiratory Function Tests / Q000379:methods / Q000662:veterinary*
D006632:Histamine