Late preventive effects on carbon tetrachloride-induced necrosis of the inhibitor of proteases 1-1-chloro-3-tosyl amido-7-amino-2-heptanone (TLCK).
The administration to rats of the inhibitor of proteases 1-1-chloro-3-tosyl-amido-7-amino-2-heptanone (TLCK) 6 or 10 h after carbon tetrachloride (CCl4), significantly prevented liver necrosis induced by this hepatotoxin at 24 h. The present and previous results from our laboratory suggest that degradative processes mediated by proteases and esterases might play a role in late stages of CCl4-induced liver cell injury.
D000590:Amino Acid Chloromethyl Ketones / Q000494:pharmacology*; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology / Q000517:prevention & control*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009336:Necrosis; D011480:Protease Inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014107:Tosyllysine Chloromethyl Ketone / Q000494:pharmacology*
D000590:Amino Acid Chloromethyl Ketones; D011480:Protease Inhibitors; D014107:Tosyllysine Chloromethyl Ketone