[Protective effect of alpha-tocopherol on the hydroxylating system in liver endoplasmic reticulum membranes against the damaging activity of hyperbaric oxygenation].
Effect of hyperbaric oxygenation (oxygen pressure 3039 hPa, exposition 3 hrs) on activity of the hydroxylating system and lipid peroxidation was studied in membranes of rat liver endoplasmic reticulum. Within the first 3 hrs after hyperbaric oxygenation the rates of aniline n-hydroxylation, amidopyrine N-demethylation, NADPH oxidation and the cytochrome P-450 level were decreased, while the rates of ascorbate- and NADPH-dependent lipid peroxidation were increased. Oil emulsion of alpha-tocopherol, administered per os into rats at a dose of 50 mg/kg every 12 hrs within 2 days before hyperbaric oxygenation, prevented the posthyperoxic deterioration of xenobiotic metabolism and the intensification of lipid peroxidation in liver microsomes.
D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004721:Endoplasmic Reticulum / Q000201:enzymology*; D006900:Hydroxylation; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000201:enzymology* / Q000378:metabolism; D008297:Male; D009249:NADP / Q000378:metabolism; D051381:Rats; D014810:Vitamin E / Q000494:pharmacology*
D008054:Lipid Peroxides; D014810:Vitamin E; D009249:NADP; D003577:Cytochrome P-450 Enzyme System; D000815:Aniline Hydroxylase
Zashchita al'fa-tokoferolom gidroksiliruiushcheĭ sistemy membran éndoplazmaticheskom retikuluma pecheni ot povrezhdaiushchego deĭstviia giperbaricheskoĭ oksigenatsii.