The role of cytoskeletal integrity in cellular transformation.
The cytoskeleton appears to function as a linkage between the nuclear and the plasma membranes, permitting environmental stimuli acting at the cell membrane to be transmitted to the nucleus for initiation of an appropriate response. This interplay can account for cases of temporary phenotypic reversions in transformed cell lines, where a deficient cytoskeleton prevents the cell membrane and nucleus from acting in a coordinated manner. Implications for the clinical aspects of cancer therapy are briefly discussed.
D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000648:ultrastructure*; D003599:Cytoskeleton / Q000502:physiology*; D005246:Feedback; D008054:Lipid Peroxides / Q000378:metabolism; D008938:Mitosis; D009685:Nuclear Envelope / Q000502:physiology
D008054:Lipid Peroxides