Synthesis and determination of 10-oxomorphine, a decomposition product of morphine.
10-Oxomorphine, a decomposition product of morphine, was synthesized from 6-O-acetylcodeine, which was oxidized with chromic acid to 6-O-acetyl-10-hydroxycodeine. This substance was then oxidized with manganese dioxide to 6-O-acetyl-10-oxocodeine, which on hydrolysis and O-demethylation gave 10-oxomorphine. UV-, fluorimetric spectrometry, TLC and HPLC methods were used for determination of 10-oxomorphine.
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002855:Chromatography, Thin Layer / Q000379:methods; D009020:Morphine / Q000032:analysis*; D009022:Morphine Derivatives / Q000032:analysis / Q000138:chemical synthesis*; D013050:Spectrometry, Fluorescence / Q000379:methods; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
D009022:Morphine Derivatives; C044406:10-oxomorphine; D009020:Morphine