Lipid peroxidation and copper toxicity in rats.
Pentane production was used as an index of lipid peroxidation in male rats fed either 0 or 1000 ppm copper in diets with and without vitamin E. Pentane production by vitamin E-deficient rats not fed copper was greater than that by vitamin E-supplemented rats not fed copper. Pentane production was low by all groups of rats. Copper-fed, vitamin E-deficient and vitamin E-supplemented rats produced more pentane than did respective controls not fed copper. After 9 weeks of feeding the diets, more pentane was produced by vitamin E-deficient than by vitamin E-supplemented rats following intraperitoneal injection of 5 mg of copper/kg of body weight, and vitamin E-deficient rats fed copper produced 5-fold more pentane than did those not fed copper. Thiobarbituric acid-reactants were highest in blood, kidney and liver from copper-fed rats. Lipid-soluble fluorophores in spleen were lowest in vitamin E-supplemented rats not fed copper and highest in copper-fed, vitamin E-deficient rats.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003300:Copper / Q000378:metabolism / Q000633:toxicity*; D005453:Fluorescence; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D010420:Pentanes / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000187:drug effects; D013858:Thiobarbiturates / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology
D008054:Lipid Peroxides; D010420:Pentanes; D013858:Thiobarbiturates; D014810:Vitamin E; C033353:pentane; D003300:Copper; C029684:thiobarbituric acid