[Evaluation of the effect of cloxacillin on human lymphocyte chromosomes through the study of karyotypic changes and sister chromatid exchanges].
The aim of this work was the evaluation of the possible mutagenic effect of an antibiotic, the Cloxacillin. Therefore the authors have performed the analysis of the chromosomal alterations and the study of the SCE (Sister Chromatid Exchanges) induced with the exposition of cultures of lymphocytes to different concentrations of this drug. The work reveals that Cloxacillin induces chromosomal alterations at high concentrations, while at concentrations similar to its therapeutic levels the drug does not seem to interfere with human DNA.
D002869:Chromosome Aberrations / Q000187:drug effects*; D003023:Cloxacillin / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D007621:Karyotyping; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D003023:Cloxacillin
Valutazione dell'effetto della cloxacillina sui cromosomi di linfociti umani attraverso lo studio delle alterazioni cariotipiche e degli sce (sister chromatid exchanges).