Effect of a single dose of triiodothyronine on the uptake of (methyl-14C)choline into chick liver phospholipids.
The effects of a single dose of 3,3'-5-triiodothyronine (T3) on the uptake of (methyl-14C) choline into liver phosphatidylcholine (PC) and lysophosphatidylcholine (LPC) were studied in chicks as a function of time up to 6 h after injection of the radioactive precursor. In all cases, chicks received the T3 dose intraperitoneally 5 h before injection of the labelled compound. T3 enhances the incorporation of 14C-choline into liver PC, showing a biphasic response; the main uptake occurs between 2 and 3 h after administering the precursor. A smaller but significant hormone-dependent increase in incorporation of the labelled compound is observed in the case of LPC. Lipid P associated to PC and LPC remains constant throughout the experiment, and does not vary with hormone treatment. It is suggested that T3-injection increases, either directly or through other metabolic processes, PC and LPC turnover in chick liver cells.
D000818:Animals; D002645:Chickens; D002794:Choline / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008244:Lysophosphatidylcholines / Q000096:biosynthesis; D010713:Phosphatidylcholines / Q000096:biosynthesis*; D013997:Time Factors; D014284:Triiodothyronine / Q000494:pharmacology*
D008244:Lysophosphatidylcholines; D010713:Phosphatidylcholines; D014284:Triiodothyronine; D002794:Choline