Decreased red cell enolase activity in a 40-year-old woman with compensated haemolysis.
A 40-year-old woman splenectomized 17 years previously for hereditary haemolytic anaemia was investigated in our laboratory because of persistent conjunctival subicterus associated with compensated haemolysis. The results of the autohaemolysis and osmotic fragility tests were similar to those usually observed in hereditary spherocytosis. Red cell enzyme assays indicated a decreased amount of kinetically normal enolase. The genetic transmission of this defect could not be established since the only other affected member of the family was the proposita's father who died several years ago after splenectomy for an undefined haemolytic disorder.
D000328:Adult; D000745:Anemia, Hemolytic, Congenital / Q000201:enzymology*; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D006801:Humans; D010375:Pedigree; D010751:Phosphopyruvate Hydratase / Q000097:blood*; D013103:Spherocytosis, Hereditary / Q000201:enzymology
D010751:Phosphopyruvate Hydratase