Interaction of vitamin A deficiency and excess fluoride in calcification of rat bones and teeth.
Using a 2 X 2 factorial design, we evaluated the possible interaction of vitamin A deficiency and excess fluoride in rat dentin and bone. Simultaneous presence of excess fluoride plus vitamin A deficiency resulted in a significant decrease in bone fluoride concentration compared to the presence of excess fluoride alone. Vitamin A deficiency alone significantly reduced calcium concentration in dentin formed during the deficient period.
D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D001835:Body Weight; D001842:Bone and Bones / Q000032:analysis / Q000378:metabolism*; D002118:Calcium / Q000652:urine; D003804:Dentin / Q000032:analysis / Q000378:metabolism*; D008297:Male; D010758:Phosphorus / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000032:analysis / Q000378:metabolism*; D014801:Vitamin A / Q000097:blood; D014802:Vitamin A Deficiency / Q000378:metabolism*
D014801:Vitamin A; D010758:Phosphorus; D012969:Sodium Fluoride; D002118:Calcium