[Properties of alkylating derivatives of estrogens].
The influence of phenestrol and XTJI-51 (hexestrol alkylating derivatives) on uterine tissues and their ability to bind to estrogen receptors were studied. The both compounds studied exhibited estrogenic properties and imitated all effects of estradiol: they increased the uterine wet weight and the activity of thymidine kinase and glucose-6-phosphate dehydrogenase. Although their affinity for estrogen receptors was much weaker than the affinity of estradiol, their complexes with estrogen receptors were more stable than estrogen-receptor complexes.
D000818:Animals; D001667:Binding, Competitive; D003600:Cytosol / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism / Q000494:pharmacology*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D008321:Mammary Glands, Animal / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011959:Receptors, Estradiol / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D013937:Thymidine Kinase / Q000378:metabolism; D014599:Uterus / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*
D011959:Receptors, Estradiol; D011960:Receptors, Estrogen; D004958:Estradiol; D005954:Glucosephosphate Dehydrogenase; D013937:Thymidine Kinase
Svoĭstva alkiliruiushchikh proizvodnykh éstrogenov.