[Effect of PS-K on experimental neurogenic tumors in rats induced by ethylnitrosourea].
The effect of PS-K as immunomodulator was studied in Fischer rats bearing neurogenic tumors induced transplacentally by ENU. 114 rats were divided into control and PS-K treated groups. all rats were subjected to an autopsy at death and all of central nervous system were examined macroscopically. Final neurogenic tumor incidence in PS-K treated groups was significantly lower than that in the control group, but distribution of these neurogenic tumors and number of neurogenic tumors in a rat remained unchanged between the control and the each PS-K treated groups. Survival time of PS-K treated groups did not increase than the control group. From these experiments, it might be that induction of neurogenic tumors may be suppressed by administration of PS-K.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D005038:Ethylnitrosourea; D009423:Nervous System Neoplasms / Q000139:chemically induced* / Q000517:prevention & control; D010524:Peripheral Nervous System Neoplasms / Q000139:chemically induced / Q000517:prevention & control; D011509:Proteoglycans / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013120:Spinal Cord Neoplasms / Q000139:chemically induced / Q000517:prevention & control
D000276:Adjuvants, Immunologic; D011509:Proteoglycans; C010770:polysaccharide-K; D005038:Ethylnitrosourea