Neuritic plaque-like structures in the rat cerebellum following prolonged alcohol consumption.
Primitive neuritic plaques were observed in the inner third of the molecular layer of the cerebellar cortex of rats following chronic alcohol consumption. Neurites were identified as dystrophic parallel fiber boutons. Amyloid material dispersed among neurites was not clearly recognized, dystrophic some fibrils were frequently seen among them. Astrocytic processes were noted in the periphery of the plaque. Microglial reaction, however, was non-existent. The rarity of these lesions in the rat cerebellum and their probable relation to long periods of alcohol consumption is discussed.
D000437:Alcoholism / Q000473:pathology*; D000682:Amyloid / Q000378:metabolism; D000818:Animals; D001369:Axons / Q000473:pathology; D002525:Cerebellar Cortex / Q000473:pathology*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009457:Neuroglia / Q000473:pathology; D051381:Rats
D000682:Amyloid