Platelet-derived growth factor induces rapid but transient expression of the c-fos gene and protein.
Exposure of quiescent mouse fibroblasts to platelet-derived growth factor induces mRNA from the c-fos proto-oncogene within 10 min followed by synthesis of nuclear c-fos proteins. These are amongst the earliest described nuclear events that follow a mitogenic stimulus.
D000818:Animals; D005347:Fibroblasts; D005786:Gene Expression Regulation / Q000187:drug effects; D051379:Mice; D008934:Mitogens / Q000494:pharmacology; D008938:Mitosis; D009857:Oncogenes; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D011499:Protein Processing, Post-Translational; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic
D008934:Mitogens; D010982:Platelet-Derived Growth Factor; D012333:RNA, Messenger