Quantitative structure-activity relationships in a set of antimuscarinic agents.
Quantitative structure-activity relationships (QSAR) have been formulated for the interactions of a set of antimuscarinic agents. The antagonistic activity is found to be dependent on hydrophobic-lipophilic character and steric requirements of substituents R1 and R2 in structures of type R1R2N--CH2--CH2--+NR3R4R5. Moreover, it is shown that the incumbrance of R3, R4 and R5 groups and their polar effects on the onium ending greatly affect the antagonistic activity. A binding model which suggests new avenues for exploration is presented.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008954:Models, Biological; D008968:Molecular Conformation; D009119:Muscle Contraction / Q000187:drug effects; D010276:Parasympatholytics / Q000494:pharmacology*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D010276:Parasympatholytics; D000644:Quaternary Ammonium Compounds; C028530:furtrethonium; D000109:Acetylcholine