[Defect in the caffeine-dependent postreplication DNA repair in UV-sensitive Chinese hamster clone cells].
The postreplication repair of DNA in the presence of caffeine was investigated in the Chinese hamster clones cells of different UV-sensitivity. Caffeine (10(-2)M) inhibits the repair of daughter DNA (PRR of DNA) in the UV-light irradiated cells of UV-resistant clones CHO-K1, 14-2C-1 and V79, but does not influence the PRR of DNA in cells of UV-sensitive clones CHS1 and CHS2. Thus, deficiency of PRR of DNA in cells of UV-sensitive clones (the repair of daughter DNA is significantly retarded) is associated with the defect of the caffeine-dependent component of this repair process.
D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D002460:Cell Line; D002999:Clone Cells / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000096:biosynthesis / Q000528:radiation effects; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects; D004261:DNA Replication / Q000187:drug effects* / Q000528:radiation effects; D008970:Molecular Weight; D011836:Radiation Tolerance; D014466:Ultraviolet Rays
D002110:Caffeine; D004247:DNA
Defekt kofein-zavisimoĭ postreplikativnoĭ reparatsii DNK v kletkakh UF-chuvstvitel'nykh klonov kitaĭskogo khomiachka.