Sodium depletion of rats induces a mitochondrial protein in the zona glomerulosa of the adrenal cortex.
Sodium restriction of rats resulted in a marked increase in the concentration of a mitochondrial protein with a mol. wt of 49000 in the zona glomerulosa of the adrenal cortex. The same protein had been previously induced in potassium deficient rats by potassium repletion. Since both sodium depletion and potassium repletion are known to stimulate the activity of the mitochondrial mixed function oxidase involved in the conversion of corticosterone to aldosterone, the present observation supports the hypothesis that the potassium-induced protein might represent cytochrome P-450CMO (corticosterone methyl oxidase).
D000302:Adrenal Cortex / Q000378:metabolism*; D000818:Animals; D003720:Densitometry; D004039:Diet, Sodium-Restricted; D004591:Electrophoresis, Polyacrylamide Gel; D008297:Male; D008928:Mitochondria / Q000378:metabolism*; D008970:Molecular Weight; D011191:Potassium Deficiency / Q000378:metabolism; D014176:Protein Biosynthesis; D051381:Rats; D012964:Sodium / Q000172:deficiency*
D012964:Sodium