In vitro serum glycogenolytic activity in rats during hypothermia induced with 2-deoxy-D-glucose.
During hypothermia induced by intraperitoneal administration of 2-deoxy-D-glucose (600 mg/kg of body weight) the serum levels of glucose and FFA rise and the hepatic glycogen content falls in relation to rats in control group. The glycogenolytic activity of the serum in vitro determined against liver slices is also higher in the group of rats receiving 2-DG. The obtained results point to an activation of the glycogenolysis process and glycolysis in the organism of rats after administration of hypothermia-inducing doses of 2-DG.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006003:Glycogen / Q000097:blood* / Q000378:metabolism; D007035:Hypothermia / Q000097:blood / Q000139:chemically induced*; D007773:Lactates / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D003837:Deoxy Sugars; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D006003:Glycogen; D003847:Deoxyglucose