Vaccination of turkeys against air-sac infection with a temperature-sensitive mutant of Mycoplasma gallisepticum.
Turkeys were vaccinated with temperature-sensitive (TS) mutants of Mycoplasma gallisepticum (MG) to determine pathogenicity and immunogenicity. TS 37 was apathogenic yet immunogenic to turkeys, TS 100 was highly pathogenic, and TS 102 was slightly pathogenic and nonimmunogenic. Five or 7 weeks after intranasal vaccination of turkeys with the TS 37 mutant, a highly statistically significant resistance against intra-air-sac challenge with the S6 strain of MG was observed.
D000400:Air Sacs; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001428:Bacterial Vaccines / Q000276:immunology*; D005260:Female; D008297:Male; D009154:Mutation; D009174:Mycoplasma / Q000235:genetics / Q000276:immunology*; D009175:Mycoplasma Infections / Q000517:prevention & control / Q000662:veterinary*; D011201:Poultry Diseases / Q000517:prevention & control*; D012141:Respiratory Tract Infections / Q000517:prevention & control / Q000662:veterinary*; D013696:Temperature; D014422:Turkeys; D014611:Vaccination / Q000379:methods / Q000662:veterinary*
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines