Antimitotic activity of strychnopentamine, a bisindolic alkaloid.
Strychnopentamine has been tested for its cytotoxic and antitumor activities and compared with two other bisindolic alkaloids that possess an usambarane skeleton. The presence of a N-methylpyrrolidine group increases the antimitotic activity of this type of alkaloids.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D002460:Cell Line; D055598:Chemical Phenomena; D002621:Chemistry; D006131:Growth Inhibitors / Q000494:pharmacology; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy; D008297:Male; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D008938:Mitosis / Q000187:drug effects*; D010947:Plants, Toxic / Q000032:analysis*; D051381:Rats; D011919:Rats, Inbred Strains
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D006131:Growth Inhibitors; C045110:strychnopentamine