[Right ventricular hemodynamics and lung function following amrinone injection].
Amrinone is a positive inotropic agent which has been widely used for treatment of left heart failure. As this drug has a relaxing effect on smooth muscle cells, we considered that hemodynamics and ventilatory mechanics could be simultaneously improved in patients with right heart failure caused by obstructive lung disease. Swan-Ganz catheters were used in 11 patients. Following injection of 1.5 mg/kg Amrinone, cardiac output increased from 6.1 to 6.9 l/min (p less than 0.05). Stroke volume showed only a slight increase; pulmonary vascular resistance was reduced from 407 to 308 dynes . s . cm-5 (p less than 0.01). Body plethysmographic examination revealed a decrease of specific airway resistance from 33 to 24 cm H2O . s (p less than 0.01).


CONCLUSIONS
In patients with right heart failure due to obstructive lung disease Amrinone application can result in an improvement in both hemodynamics and ventilatory mechanics.
D000403:Airway Resistance / Q000187:drug effects*; D000631:Aminopyridines / Q000097:blood / Q000627:therapeutic use*; D000676:Amrinone; D002316:Cardiotonic Agents / Q000097:blood / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy*; D006352:Heart Ventricles / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000150:complications; D008176:Lung Volume Measurements; D009200:Myocardial Contraction / Q000187:drug effects*
D000631:Aminopyridines; D002316:Cardiotonic Agents; D000676:Amrinone
Rechtsventrikuläre Hämodynamik und Lungenfunktion nach Amrinone-Injektion.