[Modulation of phagocytic activity with prodigiozan and obsidan].
Neutrophils and peritoneal macrophages of mice treated with prodigiozan and propranolol were studied for their capacity to reduce nitroblue tetrazolium and absorption and inactivation of the cells of staphylococci and dermatophytes. It was shown that prodigiozan stimulated bactericidal activity of phagocytes, amplified macrophage fungicidity, and decreased neutrophil fungicidity in respect to the dermatophytes. Propranolol increased the prodigiozan capacity for stimulation of the oxygen-dependent metabolism of phagocytes and absorption and inactivation of staphylococci. However, it inhibited inactivation of dermatophytes by phagocytes.
D000818:Animals; D001770:Blood Bactericidal Activity / Q000187:drug effects*; D004357:Drug Synergism; D066298:In Vitro Techniques; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D009504:Neutrophils / Q000276:immunology*; D010587:Phagocytosis / Q000187:drug effects*; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D011354:Prodigiozan / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D013210:Staphylococcus / Q000276:immunology; D014249:Trichophyton / Q000276:immunology
D011135:Polysaccharides, Bacterial; D011354:Prodigiozan; D011433:Propranolol
Moduliatsiia aktivnosti fagotsitov prodigiozanom i obzidanom.