title: An unusual case of generalized ceroid-lipofuscinosis in a cynomolgus monkey.
abstract: Histologic, histochemical, and electron microscopic studies of generalized ceroid-lipofuscinosis in a cynomolgus monkey are presented. Histologically, a wide variety of tissue cells contained numerous bright eosinophilic intracytoplasmic granules that varied in size from 0.5 micron to 4.0 microns in diameter. Histochemically, the granules gave a weakly positive reaction with periodic acid-Schiff and for lipids. They were weakly acid fast and capable of emitting autofluorescence. Ultrastructurally, the granules were single unit membrane-bound, and contained dense osmiophilic material with frequent concentric or fingerprint-type lamellar formation. The granules were different than hemofuscin, iron, and bilirubin. Tinctorially the granules were unique--they were bright red with hematoxylin and eosin and, thus, differed from typical age-related lipofuscin pigment.
mesh_terms: D000375:Aging; D000818:Animals; D003594:Cytoplasmic Granules / Q000378:metabolism / Q000648:ultrastructure; D006651:Histocytochemistry; D006801:Humans; D008062:Lipofuscin / Q000378:metabolism; D008251:Macaca; D008252:Macaca fascicularis; D008297:Male; D008992:Monkey Diseases / Q000378:metabolism / Q000473:pathology*; D009472:Neuronal Ceroid-Lipofuscinoses / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*
chemical_list: D008062:Lipofuscin