Effect of 5 alpha-dihydrocorticoids on enzymes of gluconeogenesis in rat liver.
5 alpha-Dihydrocortisol (11 beta, 17, 21-trihydroxy-5 alpha-pregnane-3,20-dione), 5 alpha-dihydrocorticosterone (11 beta, 21-dihydroxy-5 alpha-pregnane-3,20-dione) as well as cortisol (11 beta, 17, 21-trihydroxy-4-pregnene-3,20-dione) and corticosterone (11 beta, 21-dihydroxy-4-pregnene-3,20-dione) were administered for seven days to male rats. Blood glucose increased in cortisol- and corticosterone-treated rats and blood insulin decreased after 5 alpha-dihydrocorticosteroid treatment. In the liver, total protein was elevated after cortisol, corticosterone and 5 alpha-dihydrocorticosterone application. Phosphoenolpyruvate carboxykinase and fructose-1,6-diphosphatase activities in liver were significantly lowered after treatment with 5 alpha-dihydrocortisol and 5 alpha-dihydrocorticosterone.
D000818:Animals; D003345:Corticosterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D005943:Gluconeogenesis / Q000187:drug effects*; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000494:pharmacology; D008099:Liver / Q000201:enzymology*; D008297:Male; D011506:Proteins / Q000378:metabolism; D051381:Rats
D011506:Proteins; C013939:5-dihydrocorticosterone; C018921:5-dihydrocortisol; D003345:Corticosterone; D006854:Hydrocortisone