Preparation and in vivo studies of a new drug delivery system. Nanoparticles of alkylcyanoacrylate.
Polyhexylcyanoacrylate nanoparticles have been prepared with vincamine as the model drug. These particles had an average size of 200 nm and adsorbed approximately 43% of vincamine. The adsorption of vincamine to nanoparticles modified the distribution of vincamine in tissues. After iv injection the distribution volumes were increased in comparison with an aqueous solution of drug. In comparison with an aqueous solution of drug, the absolute bioavailability of vincamine was also increased after an oral administration of nanoparticles.
D000327:Adsorption; D000818:Animals; D001682:Biological Availability; D002214:Capsules; D003487:Cyanoacrylates; D004364:Pharmaceutical Preparations / Q000008:administration & dosage*; D011817:Rabbits; D014749:Vincamine / Q000008:administration & dosage / Q000378:metabolism
D002214:Capsules; D003487:Cyanoacrylates; D004364:Pharmaceutical Preparations; C042633:poly(hexyl-2-cyanoacrylate); D014749:Vincamine