Augmentation of the in vitro activity of azlocillin against Bacteroides fragilis by clavulanic acid.
Azlocillin was active against 90% of 154 strains of Bacteroides fragilis at a concentration of 64 micrograms/ml. Twenty-eight strains of B. fragilis with an azlocillin MIC of greater than or equal to 8 micrograms/ml were retested with a combination of azlocillin plus clavulanic acid. Of these strains, 71% showed a 4- to 32-fold decrease in the MIC of azlocillin plus clavulanic acid.
D001390:Azlocillin / Q000494:pharmacology*; D001441:Bacteroides fragilis / Q000187:drug effects*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000494:pharmacology*; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests
D002969:Clavulanic Acids; D019818:Clavulanic Acid; D001390:Azlocillin