BW 5147 supernatants suppress Con A stimulation of mouse spleen cells.
Conditioned medium from mouse T lymphoma BW 5147 cell cultures suppressed Con A-stimulated DNA synthesis in cultures of mouse spleen cells. Supernatants from control mouse T cell lymphoma EL-4 were not effective. Conditioned medium from BW 5147 cells did not inhibit DNA synthesis in control cultures of IL-2-dependent mouse T cells or mouse leukaemias of T cell or erythroblastic origin. It is suggested that constitutive production of a soluble suppressor factor by BW 5147 lymphoma cells is responsible for the effects observed.
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D007108:Immune Tolerance; D008213:Lymphocyte Activation; D051379:Mice; D013154:Spleen / Q000276:immunology; D013945:Thymoma / Q000276:immunology*; D013953:Thymus Neoplasms / Q000276:immunology*
D003208:Concanavalin A