Ascorbic acid nutritional status does not affect the biochemical response to paraquat.
Guinea pigs were subjected to dietary control of ascorbic acid intake to produce deficient, normal, and supplemented tissue ascorbate concentrations. Paraquat, a potent pulmonary toxin, was then administered. Tissue distribution and covalent binding of paraquat were not affected significantly by ascorbate nutritional status except for decreased 24-hr kidney burdens in deficient animals. Paraquat increased pulmonary thiobarbituric acid reactivity and mixed disulfide formation, but no evidence of either a protective or a potentiative interaction of endogenous ascorbate and paraquat was observed. This study indicates that alteration of endogenous ascorbic acid levels does not alter the biochemical response to paraquat.
D000704:Analysis of Variance; D000818:Animals; D001205:Ascorbic Acid / Q000032:analysis / Q000502:physiology*; D004220:Disulfides / Q000032:analysis; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008168:Lung / Q000032:analysis; D008297:Male; D010269:Paraquat / Q000378:metabolism / Q000633:toxicity*; D013858:Thiobarbiturates / Q000494:pharmacology; D014018:Tissue Distribution
D004220:Disulfides; D013858:Thiobarbiturates; D010269:Paraquat; D001205:Ascorbic Acid