title: High CSF lactate and pyruvate content in Kearns-Sayre syndrome.
abstract: We studied lactate and pyruvate concentrations in CSF and blood of a patient with Kearns-Sayre syndrome (KSS), 3 patients with ocular myopathy and 11 normal control subjects. We found significant elevation of lactate and pyruvate in the CSF of the patient with KSS, suggesting a disorder of CNS lactate-pyruvate metabolism.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007625:Kearns-Sayre Syndrome / Q000134:cerebrospinal fluid* / Q000473:pathology; D007773:Lactates / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D008931:Mitochondria, Muscle / Q000648:ultrastructure; D009886:Ophthalmoplegia / Q000134:cerebrospinal fluid*; D011773:Pyruvates / Q000134:cerebrospinal fluid*
chemical_list: D007773:Lactates; D011773:Pyruvates