Ciprofloxacin penetration into extravascular spaces in a rabbit model.
Ciprofloxacin penetration into extravascular spaces was studied in a rabbit Visking chamber model. The drug was administered (7 mg/kg) intramuscularly every 4 h for eight doses. Peak and trough drug levels by dose 8 were 1.3 and 0.35 micrograms/ml in serum and 0.61 and 0.50 micrograms/ml in extravascular sites. The ratio of extravascular site to serum free drug area under the drug curve by dose 8 was 91.1%. This potent, new antimicrobial agent appears to distribute freely to extravascular spaces in this animal model.
D000818:Animals; D000890:Anti-Infective Agents / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism; D002939:Ciprofloxacin; D005110:Extracellular Space / Q000378:metabolism*; D005260:Female; D008954:Models, Biological; D011485:Protein Binding; D011804:Quinolines / Q000097:blood / Q000378:metabolism*; D011817:Rabbits
D000890:Anti-Infective Agents; D001798:Blood Proteins; D011804:Quinolines; D002939:Ciprofloxacin