Platelet aggregability, disaggregability and serotonin uptake in migraine.
Several disturbances in platelet function have been reported in migraineurs including serotonin (5-HT) metabolism and abnormal aggregability of platelets. The present work compared platelets taken from migraineurs during attacks and at headache-free periods with those of controls. The results demonstrated a tendency to increased aggregability during attacks compared to headache-free periods, and lower still in controls. Kinetic analysis of 5-HT uptake revealed normal Km, increased Vmax values and lower imipramine inhibition in migraineurs (both during headache and at headache-free periods). However, although the differences were significant statistically, they were small, and their clinical relevance remains to be proven.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000097:blood*; D010974:Platelet Aggregation / Q000187:drug effects; D012701:Serotonin / Q000097:blood*
D012701:Serotonin; D000244:Adenosine Diphosphate; D004837:Epinephrine