title: [Sedimentation characteristics of the virions and subviral particles of influenza C viruses].
abstract: Investigation of sedimentation and some other properties of subviral particles and native virions of influenza C viruses was carried out in comparison with influenza A virions. Sedimentation rate of influenza C viruses was found to be 0.6 of that of influenza A viruses, the optical density peak coincided with the peaks of hemagglutinating and infectious activities of both influenza A and influenza C viruses. Studies with 4 influenza C virus strains isolated in different years revealed no differences in their sedimentation rates and the curve pattern. Electron microscopic, electrophoretic, and sedimentation analyses showed higher fragility of influenza C virions than those of influenza A virus, and their trend to self-disintegration. Our data showed significant differences in the effect of proteases on influenza A and C viruses. With due regard to these differences, we modified the method satisfactorily used for production of influenza A subviral particles. Some properties of subviral particles of influenza C virus were studied.
mesh_terms: D000818:Animals; D002642:Chick Embryo; D004587:Electrophoresis, Agar Gel; D006389:Hemagglutinins, Viral / Q000032:analysis; D009980:Influenza A virus / Q000302:isolation & purification / Q000472:pathogenicity / Q000648:ultrastructure; D008854:Microscopy, Electron; D009975:Orthomyxoviridae / Q000302:isolation & purification* / Q000472:pathogenicity / Q000648:ultrastructure; D014461:Ultracentrifugation; D014771:Virion / Q000302:isolation & purification* / Q000472:pathogenicity / Q000648:ultrastructure
chemical_list: D006389:Hemagglutinins, Viral
vernacular_title: Sedimentatsionnye kharakteristiki virionov i subvirusnykh chastits virusov grippa C.