Nodular (keloidal) scleroderma.
Two patients with progressive systemic sclerosis (PSS) developed keloidal-like nodules within areas of thickened skin. This extremely unusual event is most likely a keloidal response to the early inflammatory component of scleroderma in patients who are either genetically at risk for keloid formation or in areas of the skin that have a high predilection for keloid formation such as the chest.
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D005260:Female; D006801:Humans; D007627:Keloid / Q000209:etiology / Q000473:pathology*; D008297:Male; D012595:Scleroderma, Systemic / Q000150:complications / Q000473:pathology*; D012867:Skin / Q000473:pathology*