Oestrogenic response of the CD-1 mouse to the soya-bean isoflavones genistein, genistin and daidzin.
The soya-bean isoflavones genistein and daidzein have been reported to exhibit oestrogenic activity in mice, but there is a significant difference in the response of different mouse strains to these compounds. The CD-1 mouse was found not to respond to these oestrogenic compounds from soya-beans or to diethystilboestrol at levels previously reported to be effective in other strains.
D000818:Animals; D004054:Diethylstilbestrol / Q000494:pharmacology; D004968:Estrogens, Non-Steroidal; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D019833:Genistein; D007529:Isoflavones / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D013025:Glycine max; D014599:Uterus / Q000187:drug effects
D004968:Estrogens, Non-Steroidal; D005419:Flavonoids; D007529:Isoflavones; C040641:genistin; C013908:daidzin; D004054:Diethylstilbestrol; D019833:Genistein