Glucan effect on the survival of mice after radiation exposure.
The effect of glucan (beta-1,3-polyglucose) was investigated on the radiation-induced damage to the system of non-specific immunity in mice. A positive influence of glucan administered before exposure to a dose of 200 R was observed on the following parameters of postradiation regeneration: while blood cell count, due mainly to increased granulocyte count, increased per cent of peroxidase-positive cells in bone marrow, increased mass and cellularity of the spleen, in relation to the group of the animals not receiving the preparation. Administration of glucan 5 days before exposure to 650 R of X-rays prolonged the mean survival time. Administration of the preparation after exposure to radiation had no significant effect on the survival time of mice.
D000818:Animals; D002452:Cell Count; D005260:Female; D005936:Glucans / Q000494:pharmacology*; D006098:Granulocytes / Q000187:drug effects; D007113:Immunity, Innate / Q000528:radiation effects; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects; D007970:Leukopenia / Q000517:prevention & control; D051379:Mice; D008815:Mice, Inbred Strains; D009026:Mortality; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*
D005936:Glucans