[Role of M- and N-cholinergic systems in the recovery of motor functions after removal of the motor zones of the cerebral cortex in cats].
In chronic experiments on cats with unilateral ablations of the motor cortical area, recovery of motor function of the contralateral forelimb was observed in average on the 31-th day after ablation. Stimulation of M-cholinoreactive brain biosystems by galantamine in combination with simultaneous suppression of N-cholinoreactive biosystems by ganglerone, shortened the period of complete compesation up to 10 days. Suppression of M-cholinoreactive systems and simultaneous stimulation of N-cholinoreactive ones by metamisil combined with galantamine prolonged the recovery period up to several months. A conclusion is drawn of an important role of M- and N-cholinergic mechanisms in providing compensatory possibilities of the brain.
D000818:Animals; D001535:Benactyzine / Q000031:analogs & derivatives / Q000494:pharmacology; D001565:Benzoates / Q000494:pharmacology; D001921:Brain / Q000503:physiopathology*; D002415:Cats; D005702:Galantamine / Q000494:pharmacology; D009043:Motor Activity / Q000502:physiology*; D009044:Motor Cortex / Q000293:injuries*; D011976:Receptors, Muscarinic / Q000502:physiology*; D011978:Receptors, Nicotinic / Q000502:physiology*
D001565:Benzoates; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D005702:Galantamine; C008380:metamizil; D001535:Benactyzine; C007824:ganglerone
Rol' M- i N-kholinergicheskikh sistem v vosstanovlenii dvigatel'nykh funktsiĭ posle udaleniia motornykh zon kory bol'shikh polushariĭ u koshek.