Hemoglobin Chongqing [alpha 2(NA2)Leu----Arg] and hemoglobin Harbin [alpha 16(A14)Lys----Met] found in China.
Hemoglobin Chongqing is a new slowly-moving and unstable hemoglobin variant with a high oxygen affinity, that was discovered in five members of a Chinese family in the suburb of Chongqing. Hemoglobin Harbin is another new rapidly-moving hemoglobin variant with slightly reduced stability and slightly increased oxygen affinity, found in a Chinese woman living in Harbin. The relative amounts of these two variants in the propositi were about 9% and 18%, respectively. Sequence analyses identified a Leu----Arg substitution at position alpha 2(NA2) of Hb Chongqing, and a Lys----Met substitution at position alpha 16(A14) of Hb Harbin.
D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis*; D001797:Blood Protein Electrophoresis; D002648:Child; D002681:China; D004592:Electrophoresis, Starch Gel; D005260:Female; D006455:Hemoglobins, Abnormal / Q000032:analysis / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree
D000596:Amino Acids; D006455:Hemoglobins, Abnormal; C044392:hemoglobin Chongqing; C044393:hemoglobin Harbin