Fatal colchicine toxicity: report of a case.
This report describes fatal colchicine toxicity occurring after a total dose of 9.3 mg. The reaction was characterized by leukopenia, thrombocytopenia, hypotension. disseminated intravascular coagulation and metabolic acidosis. Autopsy findings included a markedly hypocellular bone marrow, epithelial atypia of the trachea and esophagus, mid-zonal hepatic necrosis, sepsis and small vessel occlusion by fibrin thrombi. Possible mechanisms of colchicine toxicity are discussed.
D000368:Aged; D002177:Candidiasis / Q000150:complications; D003078:Colchicine / Q000506:poisoning*; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced; D005767:Gastrointestinal Diseases / Q000150:complications; D006073:Gout / Q000188:drug therapy / Q000473:pathology; D006470:Hemorrhage / Q000150:complications; D006801:Humans; D007022:Hypotension / Q000139:chemically induced; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D013921:Thrombocytopenia / Q000139:chemically induced
D003078:Colchicine