Aminopeptidase activity in the livers of rats with experimental chronic renal failure.
Membrane-bound aminopeptidase activities in livers of rats with experimental renal failure were assayed. Only aminopeptidase A activity was decreased with the reduction in renal function, but aminopeptidase B and Leu-aminopeptidase activity did not change. The liver membrane-bound aminopeptidase A activity was inhibited by the addition of angiotensin I or -II in the enzyme assay system. From these results, it is expected that a decrease in liver membrane-bound aminopeptidase A activity may play a role in increasing angiotensin II during renal failure.
D000626:Aminopeptidases / Q000378:metabolism*; D000818:Animals; D006728:Hormones / Q000494:pharmacology; D007676:Kidney Failure, Chronic / Q000201:enzymology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008566:Membranes / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
D006728:Hormones; D000626:Aminopeptidases