A comparison of diazepam and midazolam as sedatives for minor oral surgery.
Diazepam in propylene glycol (Valium, Roche) and midazolam (Hypnovel, Roche) were compared as sedatives in 40 patients undergoing minor oral surgery. Twenty patients received each drug. The cardiovascular effects, the acceptability of the drugs to patients and dentists and the incidence of anterograde amnesia and adverse venous sequelae were investigated. Serum benzodiazepine levels were measured and recovery studied by six psychomotor tests repeated over five hours. Both drugs provided safe and acceptable sedation. More amnesia was reported in the midazolam group and more adverse venous sequelae by the diazepam patients. The recovery tests showed that the time taken to return to pre-sedation scores varied with the tests used and there was no significant evidence of the midazolam group recovering more quickly. In particular, significant impairment of delayed memory recall persisted in both groups throughout the investigation period.
D000293:Adolescent; D000328:Adult; D001569:Benzodiazepines / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology; D003975:Diazepam / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006993:Hypnotics and Sedatives / Q000009:adverse effects / Q000097:blood / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects; D008874:Midazolam; D008875:Middle Aged; D009043:Motor Activity / Q000187:drug effects; D011581:Psychological Tests; D011930:Reaction Time / Q000187:drug effects; D013515:Surgery, Oral; D013997:Time Factors; D014680:Veins / Q000293:injuries
D006993:Hypnotics and Sedatives; D001569:Benzodiazepines; D003975:Diazepam; D008874:Midazolam