[Meningioma and acoustic neurinoma occurring in two siblings of two different families].
The authors reported familial brain tumors in which meningioma and acoustic neurinoma occurred in two siblings of each two families with no evidence of the neurocutaneous syndromes, nor the familial cancer syndromes. Case A-1 is a 49-year-old female admitted to the hospital because of bilateral visual disturbance in July of 1976. A suprasellar mass was observed by CT scan. Right frontal craniotomy and removal of the tumor were done in July of 1976. Histological diagnosis was meningothelimatous meningioma. Case A-2 is a 47-year-old female, a younger sister of case A-1. Tinnitus, hearing disturbance, hemifacial sensory involvement of right side and impaired gait occurred at the end of 1981. Tomography revealed the dilatation of the right internal auditory canal. A multicystic mass was observed at the right cerebellopontine angle by CT scan. An operation was performed in May of 1982, and the tumor was diagnosed as Antoni A type neurinoma. Case B-1 is 23-year-old male who was admitted to the hospital in April of 1975, following the sudden onset of general convulsion. Left carotid angiogram showed the elevation of middle cerebral arteries and a tumor stain at the left temporal region. An operation was performed to remove the left sylvian tumor in April of 1975, and the tumor was diagnosed as transitional meningioma. Case B-2 is a 32-year-old female, an elder sister of case B-1. Bilateral tinnitus and hearing disturbance occurred in 1973. She complained left hemifacial sensory involvement and impaired gait in July of 1979. CT scan showed mass lesions with markedly contrast enhancement effect at the bilateral cerebellopontine angles. An operation was performed to remove the left tumor in November of 1979 and the right tumor in July of 1980. Histologically the both tumors were diagnosed as Schwannoma. The authors have collected reports of 117 families in which intracranial tumors occurred without evidence of the neurocutaneous syndromes and the familial cancer syndromes. Six out of 117 families showed histologically different kind of tumors, however the combination of meningioma and neurinoma could not be found. Consequently our cases of meningioma and neurinoma occurred in two siblings of two different families must be the first report.
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000473:pathology; D008579:Meningioma / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D009464:Neuroma, Acoustic / Q000235:genetics* / Q000473:pathology