In vitro effect of thyroid hormones on lipolysis of rat fat cells during aging.
The in vitro effect of triiodothyronine (T3) 10(-5) M upon lipolysis was studied on white fat cells isolated from 1.5-6- and 30-month-old rats. We couldn't see any consistent effect of this hormone upon the basal lipolysis. We observed a T3 effect on epinephrine-stimulated lipolysis on the three groups of animals. After 1 h of incubation the increase of glycerol release varies with the dose of epinephrine; after 3 h the T3 effect persisted only in the 6-month and 30-month groups.
D000273:Adipose Tissue / Q000187:drug effects* / Q000378:metabolism; D000375:Aging; D000818:Animals; D004837:Epinephrine / Q000494:pharmacology; D005990:Glycerol / Q000378:metabolism; D066298:In Vitro Techniques; D008066:Lipolysis / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014284:Triiodothyronine / Q000494:pharmacology*
D014284:Triiodothyronine; D005990:Glycerol; D004837:Epinephrine