Inhibition of acetate incorporation into lipids by adriamycin.
Adriamycin (ADM) inhibits 14C-acetate incorporation into cardiomyocytes, with the ID50 being 0.9 microM. Incorporation into neutral lipids were inhibited except for cholesterol ester. Cholesterol and phospholipids demonstrated the strongest inhibition at 5 microM ADM.
D000085:Acetates / Q000037:antagonists & inhibitors* / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D002855:Chromatography, Thin Layer; D004317:Doxorubicin / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects; D008055:Lipids / Q000096:biosynthesis*; D009206:Myocardium / Q000378:metabolism; D010743:Phospholipids / Q000096:biosynthesis; D051381:Rats
D000085:Acetates; D008055:Lipids; D010743:Phospholipids; D004317:Doxorubicin