NADP redox state and mitochondrial Ca2+ efflux: a controversial issue.
It has been shown that Ca2+ efflux from respiring liver mitochondria is promoted by the oxidized steady state of mitochondrial pyridine nucleotides (NAD(P)), whereas Ca2+ retention is favored by a more reduced state (Lehninger, A.L., Vercesi, A.E. and Bababunmi, E.A., Proceedings of the National Academy of Sciences USA, 75, 1690-1694, 1978). The physiological relevance and the molecular mechanism responsible for the process are controversial and are discussed here.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002463:Cell Membrane Permeability; D008564:Membrane Potentials; D008930:Mitochondria, Liver / Q000378:metabolism*; D009249:NADP / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats
D009249:NADP; D002118:Calcium