[Retrospective study on side effects in 410 patients in antiepileptic therapy. Proposal for new biochemical screening].
The authors evaluated hematological side effects in 410 epileptic patients under chronic therapy. The aim of the study was to find out the most suitable parametres for preliminary screening. Values outside the normal range were seen in patients treated with multiple drug therapy and in patients receiving antiepileptic drugs from 3 years at least. The following tests were the most frequently influenced: GOT, GPT, alcaline phosphatase, protrombin time, fibrinogen.
D000927:Anticonvulsants / Q000009:adverse effects*; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006801:Humans; D007122:Immunoelectrophoresis; D008297:Male; D008403:Mass Screening; D011517:Prothrombin Time; D012189:Retrospective Studies; D013448:Sulfobromophthalein
D000927:Anticonvulsants; D002556:Cerebrospinal Fluid Proteins; D013448:Sulfobromophthalein; D005340:Fibrinogen
Studio retrospettivo sugli effetti collaterali di 410 pazienti in terapia antiepilettica. Proposta di un nuovo screening bioumorale.