title: Microsomal esterification of retinol in human liver.
abstract: Recent work has shown that esterification of retinol in microsomes from rat liver, mammary gland and small intestine and from human small intestine is catalyzed by an acyl CoA: retinol acyl transferase (ARAT). The current study demonstrates ARAT activity in human liver microsomes. At optimal incubation conditions the rate of retinyl ester formation due to ARAT (0.37 +/- 0.31 nmole ester formed X mg microsomal protein-1 X minute-1, mean +/- SD, n = 6) suggests that the enzyme is of physiological importance.
mesh_terms: D000217:Acyltransferases / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008862:Microsomes, Liver / Q000201:enzymology*; D051142:Retinol O-Fatty-Acyltransferase; D014801:Vitamin A / Q000378:metabolism*
chemical_list: D014801:Vitamin A; D000217:Acyltransferases; D051142:Retinol O-Fatty-Acyltransferase