The effect of indomethacin on the local cerebral blood flow increase induced by somato-sensory stimulation.
The local cerebral blood flow in cerebral cortical and subcortical regions of the rat brain was studied with the 14C-iodoantipyrine autoradiographic technique at rest and during strong non-noxious stimulation of the nose. Patterns of local blood flow changes evoked by stimulation with and without pretreatment of indomethacin, a potent cyclooxygenase inhibitor were determined. Stimulation produced a marked heterogeneous enhancement of CBF. Indomethacin did not prevent this effect although the absolute flow levels were considerably lower in indomethacin-treated animals. Indomethacin was especially effective in reducing the cerebral cortical blood flow response to stimulation whereas the subcortical response was much less affected.
D000818:Animals; D002540:Cerebral Cortex / Q000098:blood supply; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004558:Electric Stimulation; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011984:Sensory Receptor Cells / Q000502:physiology*; D014738:Vibrissae / Q000502:physiology
D007213:Indomethacin