[Changes induced by dimethylformamide on platelet function and coagulation activity].
The effect of Dimethylformamide on platelet function and on clotting system has been studied on eight workers exposed to the product, widely used in industry as a solvent of acrylic resins. A significant reduction of the number of the platelets and a drawing out of PTT and PT has been noticed. Such informations has been explained as chronical peripheral use or as modification of phospholipid components induced by DMF instead of synthesis defect, as no significant variation of the fibrinogen and of AT III values, proteins synthetized by liver, has been observed. The platelet aggregation has pointed out, in vivo, a reduction of ADP aggregation in the exposed subjects; in vitro, increasing quantities have determined an increasing reduction of the primary ADP and adrenaline aggregation.
D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D001792:Blood Platelets / Q000187:drug effects*; D004126:Dimethylformamide / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation / Q000187:drug effects*
D004126:Dimethylformamide
Modificazioni indotte da dimetilformamide (DMF) sulla funzionalita' piastrinica e sull'attivita' coagulativa.