cis-Dichlorodiammineplatinum nephrotoxicity in rats of different ages.
In 5-, 15-, 30-, and 60-day-old rats there was a distinct decrease of body weight 24 hours after a single i.p. injection of cis-dichlorodiammineplatinum (CDDP) over a dose range from 0.25 to 2.0 mg/100 g b.w.t. Compared with a control group the kidney weights appeared nearly unchanged. The increase of blood urea nitrogen (BUN) concentrations following CDDP treatment was dose dependent and more profound in 5- and 15-day-old rats than in older animals. In higher doses, CDDP impaired the renal concentrating ability in rats of all age groups as reflected in a significant increase in urine volume with only a slightly increased renal sodium excretion. Following CDDP treatment there was a moderate proteinuria. In 30- and 60-day-old rats the renal excretion of p-aminohippurate (PAH) was more reduced by CDDP compared to younger rats.
D000367:Age Factors; D000818:Animals; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D002945:Cisplatin / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007671:Kidney Concentrating Ability; D009929:Organ Size / Q000187:drug effects; D011507:Proteinuria / Q000139:chemically induced; D051381:Rats; D011916:Rats, Inbred F344; D010130:p-Aminohippuric Acid / Q000652:urine
D002945:Cisplatin; D010130:p-Aminohippuric Acid