[Transfusion-induced acid load caused by erythrocyte concentrates in the newborn].
Erythrocyte concentrates are preferred increasingly to whole-blood transfusions in treatment of neonatal anemias. By means of their application even very important restorations of hematocrit are possible without the risk of fluid overload. A possible side-effect of these erythrocyte suspensions is a transfusion mediated acidosis, which depends on the used buffer solution, temperature and storage conditions before and during use. The case report of a preterm infant with Rh-Erythroblastosis and postpartal shock demonstrates the problem of an additional acidosis caused by the ACD-adenin stabilised erythrocyte concentrate. The impression of a transfusion mediated acidaemia is confirmed by 30 comparative pH-measurements in ACD-adenin and heparin stored erythrocytes. We conclude that erythrocyte transfusions in very ill neonates with severe disturbances of metabolism and reduced organ functions should be done with heparin erythrocyte preparations.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000138:Acidosis / Q000209:etiology*; D000328:Adult; D001805:Blood Transfusion, Intrauterine / Q000009:adverse effects*; D019343:Citric Acid; D004899:Erythroblastosis, Fetal / Q000628:therapy*; D017707:Erythrocyte Transfusion; D005078:Exchange Transfusion, Whole Blood / Q000009:adverse effects; D005260:Female; D005947:Glucose / Q000009:adverse effects / Q000031:analogs & derivatives; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy
C002113:acid citrate dextrose; D019343:Citric Acid; D005947:Glucose
Transfusionsbedingte Säurebelastung durch Erythrozytenkonzentrate im Neugeborenenalter.