Effect of clozapine and molindone on plasma and brain levels of mescaline in mice.
Levels of unchanged mescaline were examined in the plasma and brain of albino Swiss-Webster mice pretreated with various doses of either clozapine or molindone. In clozapine treated mice, the mescaline levels were statistically significantly higher at 2 and 3 h with 7.5 and 15.0 mg/kg and at 1, 2 and 3 h with 30 mg/kg. Molindone at 4.0 and 8.0 mg/kg produced no significant effect; at 16.0 and 48.0 mg/kg, the levels were significantly higher at 1 and 2 h. Elevated brain levels of mescaline by clozapine and molindone indicate an adverse metabolic interaction between a hallucinogen and drugs that are commonly used to treat mescaline-induced psychosis.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003024:Clozapine / Q000494:pharmacology*; D003984:Dibenzazepines / Q000494:pharmacology*; D005260:Female; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008635:Mescaline / Q000097:blood / Q000494:pharmacology*; D051379:Mice; D008972:Molindone / Q000494:pharmacology*; D013997:Time Factors
D003984:Dibenzazepines; D007211:Indoles; D003024:Clozapine; D008635:Mescaline; D008972:Molindone