Systemic effects of chronically administered methyl prednisolonate and methyl 17-deoxyprednisolonate.
The systemic activities of methyl prednisolonate and methyl 17-deoxyprednisolonate (1) were studied in rats. Methyl 17-deoxyprednisolonate produced significant changes in the amount of sodium ion (decreased) and potassium ion (increased) in urine; however, methyl prednisolonate had no effect on electrolyte balance. Both methyl prednisolonate and methyl 17-deoxyprednisolonate had no effect on liver glycogen content, plasma corticosterone level and relative adrenal weight. In contrast, the parent compound prednisolone caused a significant decrease in liver glycogen content, plasma corticosterone level and relative adrenal weight.
D000311:Adrenal Glands / Q000033:anatomy & histology; D000818:Animals; D003345:Corticosterone / Q000097:blood; D003900:Desoxycorticosterone / Q000494:pharmacology; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011188:Potassium / Q000652:urine; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine; D013329:Structure-Activity Relationship
D008112:Liver Glycogen; D003900:Desoxycorticosterone; C025429:methyl prednisolonate; D012964:Sodium; D011239:Prednisolone; D011188:Potassium; D003345:Corticosterone