In vivo chronic lead exposure alters [3H]nitrendipine binding in rat striatum.
The effect of lead as a neurotoxic agent has been associated with alterations in calcium metabolism. On this line, the present study shows that lead alters the characteristics of [3H]nitrendipine ([ 3H]NDP) binding to rat striatal membranes. In vitro, lead shares the action of calcium in enhancing [3H]NDP binding although it is more potent on a molar basis. In vivo, lead exposure through drinking water enhances [3H]NDP binding to crude synaptosomal membrane preparations. This effect is lost when membranes are washed with EDTA-EGTA, indicating that the increased binding is due to the persistence of lead in the brain of treated rats.
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D005260:Female; D007855:Lead Poisoning / Q000151:congenital / Q000378:metabolism*; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000378:metabolism; D009568:Nitrendipine; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013570:Synaptic Membranes / Q000378:metabolism
D009568:Nitrendipine; D009543:Nifedipine