Clozapine blocks disruptive and discriminative stimulus effects of quipazine.
Clozapine was tested in two serotonin-dependent behavioral measures. One group of rats was trained to discriminate the serotonin agonist, quipazine, from saline in a two-lever operant choice task. Pretreatment with clozapine completely blocked the discrimination of quipazine. Another group of rats was trained to bar press for milk on a variable interval schedule of reinforcement. Quipazine decreased the response rate in these animals and pretreatment with clozapine completely reversed this effect. Thus, clozapine acted as a serotonin antagonist in both measures of serotonin function.
D000818:Animals; D003024:Clozapine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D003984:Dibenzazepines / Q000494:pharmacology*; D004193:Discrimination Learning / Q000187:drug effects*; D008297:Male; D011804:Quinolines / Q000037:antagonists & inhibitors*; D011814:Quipazine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012055:Reinforcement Schedule
D003984:Dibenzazepines; D011804:Quinolines; D011814:Quipazine; D003024:Clozapine