Formation of 2-methyl-2,4-thiazolidinedicarboxylic acid from L-cysteine in rat tissues.
The adduct formed non-enzymatically from L-cysteine and pyruvate: 2-methyl-2,4-thiazolidinecarboxylic acid (CP) was isolated, and identified by the electron impact mass spectroscopy. It was found that CP is formed (by cysteine transformation) and is metabolized in rat tissues. Formation of CP from cysteine or cystine was catalysed by partially purified rat liver gamma-cystathionase.
D000818:Animals; D001711:Biotransformation; D003542:Cystathionine gamma-Lyase / Q000378:metabolism; D003545:Cysteine / Q000378:metabolism*; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013844:Thiazoles / Q000096:biosynthesis*; D053778:Thiazolidines; D013997:Time Factors; D014018:Tissue Distribution
D011773:Pyruvates; D013844:Thiazoles; D053778:Thiazolidines; C014107:2-methyl-2,4-thiazolidine dicarboxylate; D019289:Pyruvic Acid; D003542:Cystathionine gamma-Lyase; D003545:Cysteine