[Virus-like particles in cultures of rheumatoid synovial cells].
Cultures of synovial cells from 8 patients with classical or determined rheumatoid arthritis and 3 patients with non-rheumatoid arthrosis were examined electron microscopically. Cells of the monolayer formed upon prolonged incubation of tissue pieces had the conventional ultrastructure of synovial cells. In 2 out of 8 cultures of rheumatoid synovial cells after 14 days of incubation, budding virus-like particles with the external diameter of 100-120 nm were observed. Morphologically these particles were very similar to retroviruses. Isolated particles had a buoyant density in sucrose of 1.15-1.17 g/cm3.
D001172:Arthritis, Rheumatoid / Q000382:microbiology*; D002478:Cells, Cultured; D002499:Centrifugation, Density Gradient; D006801:Humans; D007181:Inclusion Bodies, Viral / Q000648:ultrastructure*; D007719:Knee Joint / Q000382:microbiology; D008854:Microscopy, Electron; D010003:Osteoarthritis / Q000382:microbiology; D013583:Synovial Membrane / Q000382:microbiology* / Q000648:ultrastructure; D013585:Synovitis / Q000382:microbiology
Virusopodobnye chastitsy v kul'turakh revmatoidnykh sinovial'nykh kletok.