[Isolation and characteristics of an antibacterial substance produced by strains of Streptococcus sp. Thom-1606. I. Study of the conditions for increasing the synthesis of an antibacterial substance during the stab cultivation of Streptococcus sp. TOM-1606].
In the process of investigations the antibacterial substance released by the producer strain has been found to be the secondary product of biosynthesis. The substance is synthetized under the conditions of low carbohydrate concentration in the culture fluid. The addition of glutamine into the culture medium at a concentration of 25 micrograms/ml increases the accumulation of the target product 4-fold in comparison with the control. The maximum synthesis of the antibacterial substance is shown to occur at the lowest rate of sucrose utilization.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D001430:Bacteriocins; D050260:Carbohydrate Metabolism; D003470:Culture Media / Q000378:metabolism; D005285:Fermentation; D005973:Glutamine / Q000378:metabolism; D008837:Micrococcus / Q000187:drug effects; D013291:Streptococcus / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D001430:Bacteriocins; D003470:Culture Media; D005973:Glutamine; C026129:tomicide
Vydelenie i kharakteristika antibakterial'noĭ substantsii, produtsiruemoĭ shtammom Streptococcus sp. TOM-1606. Soobshchenie I. Izuchenie usloviĭ povysheniia sinteza antibakterial'nogo veshchestva v protsesse glubinnogo kul'tivirovaniia Streptococcus sp. TOM-1606.