title: [Comparative studies on necrosis susceptibility of capsular tissue in arthrosis and endoprosthetic joint replacement].
abstract: We examined the rates of necrosis of newly formed capsula tissue (the number of newly formed capsular tissues with necrosis) after the reoperation of 95 cemented and 11 uncemented total and cup endoprostheses, consisting of different arteficial joint materials. A comparison was made to the joint capsular tissue of 492 patients with arthrosis. The necrosis rate shows a lack of statistical significance within the two year-groups over a period of 12 years and between the different types of prostheses by using PMMA-bone cement. Therefore, it is assumed that a biological equivalence of the prostheses wear products is reached. It is also argued that necrosis can possibly develop from the sudden increased accumulation of PMMA-bone cement particles from the bone bed, caused by the loosening of the prosthesis. In comparison the newly formed capsular tissue of the uncemented prostheses, of which no necrosis was shown, evidence is given that the development of necrosis is chiefly due the quantity of PMMA wear products present. Because of the difficulty to exactly identify the PMMA-bone cement wear products, the toxicity of the PMMA-bone cement--who ist good known and in agreement in recent literature--or its wear products continues to be of hypothetical value in the production of necrosis. This is inspite of the successful detection by the gaschromatograph of the highly toxic paratoliudine in PMMA-bone cement. On the basis of the high statistical significance of the rate of necrosis in comparing the arthrosis joint capsules (14.83%) to the newly formed capsules (73 : 100%) it is shown that the capsulare fibrosis and scar formation to the obliteration of the lymphatic vessels is of secondary importance.
mesh_terms: D000368:Aged; D001168:Arthritis / Q000473:pathology*; D002358:Cartilage, Articular / Q000473:pathology*; D005271:Femur Head Necrosis / Q000473:pathology; D006622:Hip Prosthesis; D006801:Humans; D007720:Knee Prosthesis; D008768:Methylmethacrylates / Q000009:adverse effects; D009336:Necrosis; D010003:Osteoarthritis / Q000473:pathology*; D011183:Postoperative Complications / Q000473:pathology; D011474:Prosthesis Design; D012038:Regeneration / Q000187:drug effects; D012086:Reoperation
chemical_list: D008768:Methylmethacrylates
vernacular_title: Vergleichende Untersuchungen zur Nekrosebereitschaft des Kapselgewebes bei Arthrose und endoprothetischem Gelenkersatz.