title: [N-dealkylation of chlorimipramine and chlorpromazine in patients undergoing chronic treatment with both drugs: preliminary results].
abstract: Data obtained in this preliminary study show that in patients chronically treated either with Chlorimipramine (n = 6) or with Chlorpromazine (n = 2), significant amounts of the corresponding Nor1- and Nor2-metabolites were detected in plasma. The role of these metabolites in the overall therapeutic effect is under investigation.
mesh_terms: D002746:Chlorpromazine / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use*; D002997:Clomipramine / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use*; D003863:Depression / Q000188:drug therapy; D004213:Dissociative Disorders / Q000188:drug therapy; D006801:Humans; D007099:Imipramine
chemical_list: D002997:Clomipramine; C029699:norchlorpromazine; D007099:Imipramine; D002746:Chlorpromazine
vernacular_title: Studio della N-dealchilazione di clorimipramina e clorpromazina in pazienti sottoposti a trattamento cronico con i due farmaci: risultati preliminari.