Investigations on derivatives of 5-aminomethyl-6-/p-chloro-phenyl/-4, 5-dihydro-2H-pyridazin-3-one.
Several new derivatives of 5-aminomethyl-6-/p-chlorophenyl/-4, 5-dihydro-2H-pyridazin-3-one have been obtained. The substrates, beta-aminomethyl-beta-/p-chlorobenzoyl/-propionic acid derivatives 1-5, were converted by reactions with hydrazine hydrate or monosubstituted hydrazines, i.e. phenylhydrazine and N-/beta-hydroxyethyl/-hydrazine into appropriate derivatives of 5-aminomethyl-6-/p-chlorophenyl/-4,5-dihydro-2H-pyridazin-3-one 6-18. Compounds 7, 8, 11, 12, 14, 15, and 18 show depressant activity on CNS, while compounds 7a, 9a, 10, 11, 14, 15 possess cytostatic and immunosuppressive activities.
D000818:Animals; D001921:Brain / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D007166:Immunosuppressive Agents; D011724:Pyridazines / Q000138:chemical synthesis / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D011724:Pyridazines