Excretion and peripheral metabolism of 1, 2-3H-testosterone and androgens in rats following intoxication with organophosphorous insecticides. 1--Acute exposure.
The effects of methylbromphenvinfos (MBFV) and fenitrothion on androgen levels, excretion and peripheral metabolism were studied in male rats. The insecticides were administered orally in high, single doses. Plasma testosterone levels and urinary excretion of 11-deoxy-17-ketosteroids had increased 24 and 48 h after MBVF administration. During the same time period, fenitrothion reduced plasma and urine androgens, but after 72 h significant increases in steroid levels and excretion were apparent. Investigation of the peripheral metabolism of 3H-testosterone indicated that fenitrothion markedly diminished the urinary excretion of 3H-androstenedione during the first 48 h and then increased its level after 72 h. Simultaneously, 3H-testosterone elimination was increased during the first 24-48 h and then decreased after 72 h. These data suggest that MBFV and fenithrothion in high doses can produce significant alteration in physiological hormonal balance of the male reproductive system.
D000728:Androgens / Q000378:metabolism*; D000818:Animals; D002709:Chlorfenvinphos / Q000031:analogs & derivatives / Q000506:poisoning; D005278:Fenitrothion / Q000506:poisoning; D007306:Insecticides / Q000506:poisoning*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000378:metabolism*; D014316:Tritium
D000728:Androgens; D007306:Insecticides; D014316:Tritium; D013739:Testosterone; C006037:methylbromfenvinphos; D002709:Chlorfenvinphos; D005278:Fenitrothion