[Effect of metoprolol on the flow properties of blood].
In the present article the interaction of 1- isopropylamino-3-[4-(2-methoxyethyl)-phenoxy]-2-propanol (metoprolol, Beloc) with human erythrocytes is reported. Metoprolol is well known and acts mainly as a selective beta-1-antagonist. While erythrocyte aggregation, suspension osmolality and pH-values were unchanged, red cell deformability was markedly improved. Investigation into the furosemide-sensitive fluxes resulted in an inhibition of sodium efflux and in a constant water content of human erythrocytes. These in vitro results suggest that metoprolol induced improvement of red cell deformability cannot be explained by shape changes of erythrocytes.
D001809:Blood Viscosity / Q000187:drug effects*; D002449:Cell Aggregation / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D006400:Hematocrit; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008790:Metoprolol / Q000097:blood*; D008855:Microscopy, Electron, Scanning; D009994:Osmolar Concentration; D012964:Sodium / Q000097:blood; D013997:Time Factors
D012964:Sodium; D008790:Metoprolol
Der Effekt von Metoprolol auf die Fliesseigenschaften des Blutes.