Contrast media induced pulmonary edema. Comparison of ionic and nonionic agents in an animal model.
High intravenous doses of diatrizoate are known to induce pulmonary edema in the rat. The newer generation of contrast media--nonionics and monovalent dimers--are considered less toxic than diatrizoate. In this study we evaluated the degree of pulmonary edema induced by a high dose (6 g I/kg) of these new agents and found that Ioxaglate produced higher lung weights than Renografin 60 and Iopamidol. Iohexol and Amipaque did not induce a significant degree of edema. The model used in this study demonstrates distinct differences in pulmonary toxicity among these new agents, when given in doses exceedingly higher than given in clinical practice.
D000818:Animals; D003287:Contrast Media / Q000633:toxicity*; D003973:Diatrizoate / Q000633:toxicity; D003974:Diatrizoate Meglumine / Q000633:toxicity; D004338:Drug Combinations / Q000633:toxicity; D007472:Iohexol; D007479:Iopamidol; D007483:Iothalamic Acid / Q000031:analogs & derivatives / Q000633:toxicity; D007485:Ioxaglic Acid; D008297:Male; D008793:Metrizamide / Q000633:toxicity; D011654:Pulmonary Edema / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D014283:Triiodobenzoic Acids / Q000633:toxicity
D003287:Contrast Media; D004338:Drug Combinations; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; D007483:Iothalamic Acid; D003974:Diatrizoate Meglumine; D007472:Iohexol; C027278:urovision; D007479:Iopamidol; D008793:Metrizamide; D007485:Ioxaglic Acid