title: Perfusion of the cerebral cortex by use of abdominal counterpulsation during cardiopulmonary resuscitation.
abstract: Perfusion of the cerebral cortex (rCCBF) during resuscitation from cardiac arrest was studied using 24 large dogs and three different resuscitation models. Conventional cardiopulmonary resuscitation (CPR) was compared with interposed abdominal compression CPR (IAC-CPR) and with IAC-CPR together with infusion of epinephrine. Conventional CPR produced a mean rCCBF of only 11% (0.057 +/- 0.07 ml/min/g) normal perfusion (0.54 +/- 0.14 ml/min/g). Even without epinephrine, IAC-CPR produced mean rCCBF equal to 51% (0.27 +/- 0.17 ml/min/g) of normal. With epinephrine, IAC-CPR produced rCCBF (0.93 +/- 0.49 ml/min/g) statistically indistinguishable from normal. Both models of IAC-CPR were significantly superior to conventional CPR in perfusion of the cerebral cortex.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002540:Cerebral Cortex / Q000098:blood supply*; D004195:Disease Models, Animal; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology; D006323:Heart Arrest / Q000503:physiopathology; D012039:Regional Blood Flow / Q000187:drug effects; D012151:Resuscitation / Q000379:methods*
chemical_list: D004837:Epinephrine