Severe liver injuries due to sulfamethoxazole-trimethoprim and sulfamethoxydiazine.
Two cases of severe sulfonamide liver injury are described. In one patient, fulminant liver failure developed after two days of taking sulfamethoxazole-trimethoprim. The patient was treated with resin hemoperfusion and recovered completely. Another patient became jaundiced after using sulfamethoxydiazine for ten days. Very severe intrahepatic cholestasis developed and cleared up only after high-dose prednison treatment. Marked hyperbilirubinemia persisted for four months and aminotransferase activity had not normalized ten months after the onset of the disease.
D000328:Adult; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects; D056486:Chemical and Drug Induced Liver Injury; D004338:Drug Combinations; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013417:Sulfameter / Q000009:adverse effects*; D013424:Sulfanilamides / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects*
D000892:Anti-Infective Agents, Urinary; D004338:Drug Combinations; D013424:Sulfanilamides; D013417:Sulfameter; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim