[Effectiveness of vitamin E and sodium selenate in carbon tetrachloride-induced liver damage depending on the season].
Seasonal features of the efficacy of antioxidants for liver poisoning with carbon tetrachloride (CCl4) were revealed in 175 random-bred male rats. Liver function was appraised according to the bile secretion characteristics (bile secretion rate, the level of bile acids, cholesterol and bilirubin in bile). It was discovered that CCl4 hepatotoxicity was the highest during spring and summer. Vitamin D was more efficacious in spring and summer, whereas sodium selenite in autumn and winter. The use of combined vitamin E and sodium selenite prevered the toxic action of CCl4 on the liver in autumn, winter and spring and minimized it in summer. The mechanisms of seasonal differences in the action of CCl4 on the liver and antioxidant efficacy for damage in question are discussed. The conclusion was made about an important role of the time factor in the prophylaxis and treatment with antioxidants of liver toxic damages.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications*; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000517:prevention & control; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D008297:Male; D051381:Rats; D012621:Seasons; D064586:Selenic Acid; D012643:Selenium / Q000008:administration & dosage / Q000627:therapeutic use*; D018036:Selenium Compounds; D014810:Vitamin E / Q000008:administration & dosage / Q000627:therapeutic use*
D018036:Selenium Compounds; D014810:Vitamin E; D012643:Selenium; D064586:Selenic Acid
Effektiveness vitamina E i selenita natriia pri porazhenii pecheni chetyrekhkhloristym uglerodom v zavisimosti ot sezona goda.