title: A review of health risks in acrylonitrile industry.
abstract: The Occupational Health Branch of the Ontario Ministry of Labour began a study in 1978 for the evaluation of health risks associated with acrylonitrile (AN) exposure. Detailed hygiene and medical investigations were conducted in fourteen plants for evaluating AN exposure in various industrial processes. For companies were also studied in relation to mixed chemical exposure representing acrylic fibres, nitrile rubber, ABS-resin, and acrylic emulsions production. The possible interaction between AN and other coexisting chemical exposures was reviewed since dimethyl formamide, styrene, and butadiene have similar pharmacokinetics and possible synergistic effects. Exposure in acrylic fibre production may be synergistic and carcinogenic. Results of air monitoring indicated exposure levels to AN below 2 ppm (TWA) in most cases. Exposure to other co-existing chemicals was evaluated. Results of medical tests indicated no significant abnormalities in chest x-rays or liver function tests in currently exposed workers.
mesh_terms: D000081:Acetamides / Q000378:metabolism; D000181:Acrylonitrile / Q000009:adverse effects* / Q000032:analysis / Q000378:metabolism; D000395:Air Pollutants, Occupational / Q000009:adverse effects / Q000032:analysis; D001711:Biotransformation; D002617:Chemical Industry; D004126:Dimethylformamide / Q000378:metabolism; D004357:Drug Synergism; D006801:Humans; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D009570:Nitriles / Q000009:adverse effects*; D009784:Occupational Diseases / Q000139:chemically induced; D012306:Risk
chemical_list: D000081:Acetamides; D000395:Air Pollutants, Occupational; D009570:Nitriles; D004126:Dimethylformamide; C013959:dimethylacetamide; D000181:Acrylonitrile