[Choice of a central analgesic for anesthesia with spontaneous respiration].
The ventilatory effects of tramadol (T) and nefopam (N) are evaluated in anesthetized patients with enflurane in a closed circuit breathing system and compared with the effects of pentazocine (P). The following parameters tidal volume (VT), minute ventilation (V), CO2 (capnometry) occlusion pressure (OP), ventilatory response to hypercarbia are recorded after 30 minutes of anaesthesia, before and after repeated injections of the analgesics, P: 15 mg, N: 40 mg, T: 100 mg are injected I.V., and analgesics administration is repeated at 30 minutes interval, so that the patients receive a total P dose of 30 mg, a total N dose of 60 mg and a total T dose of 200 mg. The administration of 15 mg of P induces a change in VT (-24%), ventilatory frequency (-40%), OP (-18) OP only returns to basal values after a second dose. The ventilatory response to hypercarbie is indeed satisfying (increase of 61% in V). After N and T, ventilatory frequency is not disturbed. V increases of 16% and 11% respectively after the first injection, and of 31% and 2% after the second injection. OP increases by 39% and 56% respectively after the first injection and gets better over time with nefopam (+ 58%), 30 mg of P. 20 mg of N and 100 mg of T are equivalent for analgesia.(ABSTRACT TRUNCATED AT 250 WORDS)
D000293:Adolescent; D000328:Adult; D000368:Aged; D000700:Analgesics / Q000494:pharmacology*; D000769:Anesthesia, Inhalation; D003511:Cyclohexanols / Q000494:pharmacology*; D004341:Drug Evaluation; D004737:Enflurane; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009340:Nefopam / Q000494:pharmacology*; D010079:Oxazocines / Q000494:pharmacology*; D010423:Pentazocine / Q000494:pharmacology; D011897:Random Allocation; D012119:Respiration / Q000187:drug effects*; D013990:Tidal Volume; D014147:Tramadol / Q000494:pharmacology*
D000700:Analgesics; D003511:Cyclohexanols; D010079:Oxazocines; D014147:Tramadol; D009340:Nefopam; D004737:Enflurane; D010423:Pentazocine
Choix d'un analgésique central pour l'anesthésie avec respiration spontanée.