title: The sensitivity of hippocampal pyramidal neurons to serotonin in vitro: effect of prolonged treatment with clorgyline or clomipramine.
abstract: The sensitivity of hippocampal pyramidal neurons to the depressant action of serotonin was studied in hippocampal slices obtained from rats treated repetitively with clomipramine (10 mg/kg i.p.; 10 days or 4 weeks), with clorgyline 0.3 mg/kg s.c.; 10 days) or with the vehicle. Whereas clorgyline produced a very pronounced subsensitivity to serotonin, a moderate, non-significant reduction in sensitivity was observed with clomipramine. These electrophysiological findings are consistent with previous biochemical studies.
mesh_terms: D000818:Animals; D002997:Clomipramine / Q000494:pharmacology*; D003010:Clorgyline / Q000494:pharmacology*; D004347:Drug Interactions; D004594:Electrophysiology; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*
chemical_list: D011437:Propylamines; D012701:Serotonin; D003010:Clorgyline; D002997:Clomipramine