Studies of the vasorelaxant effect of acetate.
Sodium acetate caused dose-dependent relaxation of helical rat tail artery strips constricted by phenylephrine, potassium chloride and arginine vasopressin. Substantial relaxation was evident at acetate concentrations as low as 4 mM. The results suggest that the vasodilatation of acetate is not limited to receptor-dependent or voltage-dependent mechanisms. Acute increases in bath sodium chloride concentration resulted in marked relaxation of vessel strips constricted by phenylephrine and potassium chloride. Arginine vasopressin-constricted strips were quite resistant to the vasorelaxant effect of increased bath sodium chloride.
D000085:Acetates / Q000494:pharmacology*; D019342:Acetic Acid; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014662:Vasoconstrictor Agents / Q000494:pharmacology; D014664:Vasodilation / Q000187:drug effects*
D000085:Acetates; D014662:Vasoconstrictor Agents; D019342:Acetic Acid