Correlation between disintegration, dissolution and in vivo absorption rate in the case of compounds with benzyl-isoquinoline structures and its pharmacokinetic aspects.
Investigations have proved that in the case of po preparations disintegration time, dissolution rate and in vivo absorption rate are closely interrelated. These correlations described by adequate mathematical formulas are valid in the case of papaverine, drotaverine and Depogen--compounds with benzyl-isoquinoline structure.
D000042:Absorption; D000818:Animals; D002626:Chemistry, Pharmaceutical; D002851:Chromatography, High Pressure Liquid; D004058:Diffusion; D004285:Dogs; D004338:Drug Combinations / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000378:metabolism*; D007700:Kinetics; D010208:Papaverine / Q000031:analogs & derivatives / Q000378:metabolism; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets; D013806:Theophylline / Q000031:analogs & derivatives / Q000378:metabolism
D004338:Drug Combinations; D007546:Isoquinolines; D013607:Tablets; C034813:drotaverine, acephyllinate drug combination; C005317:drotaverin; D013806:Theophylline; D010208:Papaverine