[Increased erythrocyte membrane permeability to sodium--a risk factor for hypertension].
Monitoring the sodium-lithium counter transport, the authors examined the membrane permeability of red cells for sodium in 70 females and 127 males aged 20 to 70 years. In subjects with normal arterial pressure, the membrane permeability of the red cells showed no age-specific changes or differences in males and females at the age of 20 to 31 years and those over 40 years. Arterial hypertension (AH) according to the WHO criteria was diagnosed in 31% of those studied. The individuals with an increased permeability of the red cell membrane for sodium, exhibited AH twice as frequently as the individuals with the normal or decreased permeability. The rate of AH was found to rise (from 46 to 68%) with age in the subjects with the elevated permeability of the red cell membrane whilst there was no such tendency in the individuals with normal and decreased permeability of the red cell membrane.
D000328:Adult; D000368:Aged; D000375:Aging; D001794:Blood Pressure; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000209:etiology; D008094:Lithium / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D012306:Risk; D012727:Sex Characteristics; D012964:Sodium / Q000097:blood*
D008094:Lithium; D012964:Sodium
Povyshennaia pronitsaemost' membrany éritrotsitov dlia natriia--faktor riska zabolevaniia gipertonicheskoĭ bolezn'iu.