[Effect of GABA and piracetam on cerebral circulation and the neurogenic mechanisms of its regulation].
Resistography was applied in acute cat experiments to study the effects of GABA and piracetam on the neurogenic pressor vascular reactions of cerebral and hind limb vessels, induced by stimulation of bulbar structures (locus coeruleus field), of the cervical sympathetic and tibial nerves. GABA (50 mg/kg) and piracetam (100 mg/kg) reduced the central and reflex evoked contractions of the cerebral vessels but enhanced their reflex evoked reactions. A possible mechanism of such drug actions is discussed.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002561:Cerebrovascular Disorders / Q000188:drug therapy / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006614:Hindlimb / Q000098:blood supply; D009474:Neurons / Q000187:drug effects*; D010889:Piracetam / Q000494:pharmacology* / Q000627:therapeutic use; D011311:Pressoreceptors / Q000187:drug effects; D011760:Pyrrolidinones / Q000494:pharmacology*; D013035:Spasm / Q000188:drug therapy / Q000503:physiopathology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology* / Q000627:therapeutic use
D011760:Pyrrolidinones; D005680:gamma-Aminobutyric Acid; D010889:Piracetam
Vliianie GAMK i piratsetama na mozgovoe krovoobrashchenie i neĭrogennye mekhanizmy ego reguliatsii.