Calcium complexes of xanthine derivatives: a new aspect of the mode of action of haemorheologically active drugs.
External Ca2+-ions as well as certain xanthine derivatives are known to influence red blood cell properties. Therefore interaction of some xanthine derivatives with Ca-salts have been examined in vitro. Synthesis of five Ca-xanthine derivative complexes is described. The ability of complexing Ca2+-ions gives an insight into the probable mode of action of certain xanthine drugs.
D001809:Blood Viscosity / Q000187:drug effects; D002118:Calcium / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D012212:Rheology; D014970:Xanthines / Q000138:chemical synthesis / Q000494:pharmacology*
D014970:Xanthines; D002118:Calcium