title: Screening for early detection of radiation-associated thyroid cancer: a pilot study.
abstract: In the 1950s, approximately 20,000 Israeli children received scalp irradiation as treatment for tinea capitis (ringworm of the scalp). To evaluate the necessity and feasibility of early screening of these individuals for thyroid cancer, a small pilot program was undertaken. The examination consisted of a thorough palpation of the thyroid gland and the surrounding area. A 99mTc thyroid scan and thyroid function tests were performed on individuals in whom palpation suggested a nodular abnormality. A multidisciplinary committee then made a recommendation for or against surgery. A total of 443 persons were screened, and nodular abnormalities of the thyroid were detected in 24 (5.4%). Of these persons, nine displayed symptomatology or reported knowledge of a thyroid condition; despite this, three of them were not receiving treatment. This left 18 subjects--15 new cases and 3 previously untreated patients--needing follow-up care. Altogether nine persons were recommended for surgery, but one refused. All eight of the excised lesions were benign: four colloid nodules and four adenomas. While the screening program was feasible, the fact that no cancers were detected suggested that in a population exposed to a very low dose of radiation, thyroid screening may not be justified on a large scale.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007557:Israel; D008297:Male; D008403:Mass Screening / Q000191:economics / Q000379:methods*; D010865:Pilot Projects; D011878:Radiotherapy / Q000009:adverse effects*; D012306:Risk; D013964:Thyroid Neoplasms / Q000453:epidemiology* / Q000209:etiology; D013997:Time Factors