[Reaction of the ovary of the young rat to transplantation into the spleen of adult castrated diabetic animals].
The ovary of an infantile rat was grafted into the spleen of adult castrated females. After 7-9 days half of the animals were injected with alloxan subcutaneously. The rats were decapitated 33 days after ovary grafting. In all diabetic rats and 62% of the control animals, the vaginal smears showed persistent diestrus. The height of the uterine epithelium was fairly low. Persistent estrus was detected in 38% of the control animals. In the diabetic group, the degree of ovarian hypertrophy was significantly lower than in the control group, although no differences were discovered in pituitary gonadotropin content in both the groups. It is suggested that the pituitary of diabetic animals slightly responds to estrogenic deficiency. This was manifested in a lesser degree of ovarian hypertrophy and in the absence in the ovaries of the majority of diabetic rats of the phenomena such as the proliferation of the connective tissue and the appearance of granulocellular tissue accumulations.
D000375:Aging; D000818:Animals; D002369:Castration; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004031:Diestrus; D005260:Female; D006984:Hypertrophy / Q000209:etiology; D010053:Ovary / Q000473:pathology / Q000637:transplantation*; D010902:Pituitary Gland / Q000503:physiopathology; D011247:Pregnancy; D051381:Rats
Reaktsiia iachnika infantil'noĭ krysy na transplantatsiiu v selezenku vzroslykh kastrirovannykh diabeticheskikh zhivotnykh.