Colorectal juvenile polyps: an epidemiological and histopathological study of 144 cases in Jordanians.
The minimal incidence rate of colorectal juvenile polyps in Jordanians was 1.4 per 100 000 in the general population and 2.8 per 100 000 in children under 10 years of age. Out of 144 cases, nine had two to seven polyps and one juvenile polyposis coli. There was male preponderance and a mean age of 8 years: 96.5% of the polyps were in the rectum. Characteristically, stromal oedema, inflammation, ulceration with granulation tissue cap formation and gland regeneration were present. Epithelial hyperplasia was not uncommon and focal dysplastic change was occasionally noted, being always accompanied by hyperplastic change. Focal severe dysplasia was seen in one solitary juvenile polyp. It is concluded that varying degrees of focal epithelial atypia can occasionally develop in solitary juvenile polyps, rarely reaching severe dysplastic change. Malignant transformation in the commonly seen form of juvenile polyp (solitary type) is probably a rare phenomenon, but its frequency needs further evaluation.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D003111:Colonic Polyps / Q000453:epidemiology / Q000473:pathology*; D005260:Female; D006801:Humans; D007417:Intestinal Polyps / Q000453:epidemiology / Q000473:pathology*; D007597:Jordan; D008297:Male; D012004:Rectal Neoplasms / Q000453:epidemiology / Q000473:pathology*; D012737:Sex Factors; D012811:Sigmoid Neoplasms / Q000453:epidemiology / Q000473:pathology