Study of ocular tissue changes, brain GABA and polyamine levels in rats exposed to carbon disulfide.
The authors observed Wistar rats exposed to the various concentrations of carbon disulphide. They studied as the histological tissue changes as brain GABA and polyamine levels. They found the identical tissue changes in the both exposed groups and changes in the control one. The level of spermine was increased for about 1103% in the brain of animals exposed to CS2 concentration of 2500 mg/m3 and 137% in exposure to 5000 mg/m3 of CS2, which differences were statistically significant in comparison with the control group. It suggests that CS2 was producing inhibition of enzyme system involved in the degradation of spermine.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002246:Carbon Disulfide / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005123:Eye / Q000187:drug effects* / Q000378:metabolism; D006651:Histocytochemistry; D008297:Male; D011073:Polyamines / Q000378:metabolism*; D011700:Putrescine / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013096:Spermine / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D011073:Polyamines; D013096:Spermine; D005680:gamma-Aminobutyric Acid; D002246:Carbon Disulfide; D011700:Putrescine