Non-activated progesterone receptor extracted from nuclei of hen oviduct.
When the progesterone receptor was extracted from nuclei of laying hen oviduct with 0.5 M sodium molybdate, a large, 7-8 S, form of the receptor was observed. This receptor form resembled non-activated cytoplasmic receptor not only in displaying the same sedimentation coefficient, but also in rapid dissociation rate of the hormone-receptor complex. This finding suggests that either activation may occur within the nuclear compartment, or that activation may be reversed under certain conditions.
D000818:Animals; D002467:Cell Nucleus / Q000032:analysis*; D002499:Centrifugation, Density Gradient; D002645:Chickens; D005260:Female; D007700:Kinetics; D010057:Oviducts / Q000032:analysis*; D011980:Receptors, Progesterone / Q000302:isolation & purification*
D011980:Receptors, Progesterone