Observable tumours, risk assessment and experimental design.
The first goal of this article is to outline a design for an efficient experiment for testing each of many chemicals for carcinogenic potential by dermal exposure, including a risk assessment when appropriate. The second is to validate a general mathematical model for the dose-response function in this situation by using the results from a large experiment in skin painting done by the Oak Ridge National Laboratory. These two goals are related because the general model is used as a guide in the choice of an efficient design for testing the many chemicals on which information is required.
D000818:Animals; D002274:Carcinogens, Environmental / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008433:Mathematics; D051379:Mice; D008954:Models, Biological; D009784:Occupational Diseases / Q000139:chemically induced*; D010578:Petroleum; D012306:Risk; D012869:Skin Absorption; D012878:Skin Neoplasms / Q000139:chemically induced*
D002274:Carcinogens, Environmental; D010578:Petroleum