Heterogeneous oxygenation of rectal carcinomas in humans: a critical parameter for preoperative irradiation?
Tissue oxygenation was measured in 10 patients with differentiated adenocarcinoma in a very localized region in the middle part of the rectum (grade I - II, clinical stage II) by means of a cryophotometric micromethod. The results obtained clearly show that the oxygenation of differentiated rectal adenocarcinoma is distinctly lower than that of the normal rectal mucosa; tissue hypoxia or even anoxia are a common feature in those tumors; There exist considerable inter- individual differences among tumors of the same clinical staging and histological grading; substantial intra- individual heterogeneities in the oxygenation are evident within the same tumor and even within neighbouring microareas of the tissue. These findings imply that the commonly used classifications do not allow any conclusions concerning the oxygenation status, and probably the radiosensitivity of a tumor, respectively.
D000230:Adenocarcinoma / Q000378:metabolism* / Q000532:radiotherapy / Q000601:surgery; D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000378:metabolism; D008875:Middle Aged; D010101:Oxygen Consumption; D010108:Oxyhemoglobins / Q000378:metabolism; D011836:Radiation Tolerance; D012004:Rectal Neoplasms / Q000378:metabolism* / Q000532:radiotherapy / Q000601:surgery
D010108:Oxyhemoglobins