A balance study of 14C-labelled 3H-imidazo[4,5-f]quinolin-2-amines (IQ and MeIQ) in rats.
The absorption and excretion of 14C-labelled 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) and 2-amino-3,4-dimethylimidazo[4,5-f]quinoline (MeIQ) were studied in rats of both sexes. The excretion was rapid and within 24 hr more than 90% of the radioactivity had left the rats. After 72 hr the faecal excretion of both compounds was approximately 45-65% and the corresponding excretion via the urine amounted to 37-49%. Only 1-2% was left in the carcasses and less than 0.2% was found in the expired air. About 70% of the IQ and 80% of the MeIQ was found in the bile fluid in a separate 24-hr study. The two compounds had different biliary excretion patterns and the mutagenicity of the bile correlated closely with the excretion of radioactivity.
D000818:Animals; D001646:Bile / Q000032:analysis; D001944:Breath Tests; D002250:Carbon Radioisotopes; D005243:Feces / Q000032:analysis; D005260:Female; D007553:Isotope Labeling; D008297:Male; D009152:Mutagenicity Tests; D011804:Quinolines / Q000378:metabolism* / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains
D002250:Carbon Radioisotopes; D011804:Quinolines; C029216:2-amino-3-methylimidazo(4,5-f)quinoline; C036989:2-amino-3,4-dimethylimidazo(4,5-f)quinoline