title: Androgen-dependent peptides of the rat ventral prostate nuclear envelope.
abstract: Nuclear envelope peptides of the rat ventral prostate in the molecular weight region 18,400 to 19,400 show marked androgen dependence. After castration these peptides disappear. Re-administration of testosterone restores them. They were not extracted by 0.1 M NaCl or 5% HClO4 but were partially extracted by 0.35 M NaCl and 1% Triton. These peptides were not present in rat liver nuclear envelopes. As these androgen-dependent non-histone peptides have similar characteristics to androgen-dependent peptides identified in the prostate nucleus, we conclude that the nuclear peptides are at least partially localized to the nuclear envelope.
mesh_terms: D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D008970:Molecular Weight; D009685:Nuclear Envelope / Q000187:drug effects / Q000378:metabolism*; D009698:Nucleoproteins / Q000378:metabolism*; D010455:Peptides / Q000302:isolation & purification / Q000378:metabolism; D011467:Prostate / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D008565:Membrane Proteins; D009698:Nucleoproteins; D010455:Peptides; D013739:Testosterone