[Dosage interval and in vivo action of penicillin against pneumococci].
The relationship between dosage intervals of penicillin and bactericidal efficacy was investigated in an experimental model using normal and granulocytopenic mice and Streptococcus pneumoniae. Pulsdosing at 4-hour intervals proved to be significantly less efficient than fractional doses of the same total amount of penicillin injected at 1-hour intervals.
D000380:Agranulocytosis / Q000150:complications; D000818:Animals; D004305:Dose-Response Relationship, Drug; D051379:Mice; D010406:Penicillins / Q000008:administration & dosage*; D011008:Pneumococcal Infections / Q000150:complications / Q000188:drug therapy*; D013997:Time Factors
D010406:Penicillins
Dosierungsintervall und In-vivo-Wirkung von Penicillin gegen Pneumokokken.