title: Toxicity of seeds of three Aesculus spp to chicks and hamsters.
abstract: Seeds of horse chestnut (Aesculus hippocastanum), Ohio buckeye (A glabra), and yellow buckeye (A octandra) were tested for toxicity to 2-week-old Leghorn chicks and adult female Syrian hamsters. The LD50 of the water soluble portion of alcoholic extracts of horse-chestnut seeds (for hamsters and chicks) and of dried, powdered seeds (chicks only) was determined. The LD50 for a single dose of extract from horse-chestnut seeds was 10.6 mg/g of body weight for chicks and 10.7 mg/g of body weight for hamsters. The LD50 for chicks given 2 consecutive daily doses of horse-chestnut seed was 6.5 mg/g. Toxic signs included depression, muscular incoordination, paralysis, coma, and death. Extracts of seeds of Ohio buckeye were nontoxic to chicks and hamsters when fed at 80 mg/g. One of 5 hamsters died after dosing for 5 days with 80 mg/g of extract of seeds of yellow buckeye/g.
mesh_terms: D000818:Animals; D002645:Chickens; D006224:Cricetinae; D005260:Female; D008647:Mesocricetus; D010936:Plant Extracts / Q000506:poisoning*; D010946:Plants, Medicinal; D011201:Poultry Diseases / Q000209:etiology* / Q000503:physiopathology; D012376:Rodent Diseases / Q000209:etiology* / Q000503:physiopathology; D012639:Seeds
chemical_list: D010936:Plant Extracts