[Effect of isatin and its derivatives on some indicators of carbohydrate metabolism].
Effect of isatin and of three its derivatives on content of lactate, pyruvate and glycogen was studied in rat tissues. The substances studied, except of 5-butylisatin, decreased the content of lactic acid with simultaneous increase of glycogen content in liver tissue under normal conditions. The pyruvate content was most markedly altered in presence of 5-bromoisatin and 5-butylisatin. In deficiency of oxygen a distinct increase in content of lactate and pyruvate was noted in animal tissues after the 5-bromoisatin preadministration. Under conditions of oxygen deficiency the substances studied were of distinct significance for more economical utilization of glycogen in liver tissue and skeletal muscles.
D000818:Animals; D050260:Carbohydrate Metabolism; D006003:Glycogen / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D000860:Hypoxia / Q000378:metabolism*; D007211:Indoles / Q000494:pharmacology*; D007510:Isatin / Q000031:analogs & derivatives / Q000494:pharmacology*; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D011773:Pyruvates / Q000378:metabolism; D051381:Rats; D014018:Tissue Distribution
D007211:Indoles; D007773:Lactates; D011773:Pyruvates; C044415:5-butylisatin; D019344:Lactic Acid; D007510:Isatin; C044414:5-bromoisatin; D006003:Glycogen
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