[Changes in blood lipoproteins in patients with peripheral atherosclerosis after hemosorption].
Concentrations of cholesterol, triglycerides and the molar ratio cholesterol/phospholipids were higher while the values of cholesterol in high density lipoproteins (HDL) was lower in blood of patients with obliterating peripheric atherosclerosis as compared with control values. After extracorporal haemosorption on columns with activated charcoal and preadministration of heparin all the patterns studied were decreased, thus indicating the sorption of all the lipoprotein classes, including anti-atherogenic HDL, simultaneously with lipolysis of very low density lipoproteins, triglycerides as well as the sorption and destruction of large erythrocytes containing relatively high amount of cholesterol. Within the subsequent period all the patterns studied returned to the initial level. At the same time, concentration of HDL cholesterol, which, as shown earlier, correlated inversely with severity of clinical manifestations in the patients, continued to increase, exceeding the initial level by 39% within 7-14 days; these data were also corroborated by polyacrylamide gel disc electrophoresis. The alterations found may be among the factors, responsible for favourable clinical effect of haemosorption in the patients with peripheric atherosclerosis. Possible reasons for the HDL concentration increase are discussed.
D001161:Arteriosclerosis / Q000097:blood* / Q000628:therapy; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D004591:Electrophoresis, Polyacrylamide Gel; D006464:Hemoperfusion; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol
Izmeneniia lipoproteidov krovi u bol'nykh perifericheskim aterosklerozom posle gemosorbtsii.