title: Regional ultrastructural and cytochemical comparisons of the epithelial-mesenchymal interface during rat incisor development.
abstract: A major theme in understanding epithelial-mesenchymal interactions during development focuses upon regional mesenchyme specification of epithelial differentiation. One particularly useful epidermal organ system for studying this issue is the rodent continuously growing and erupting incisor tooth organ. One advantage of this particular system resides in the regional features of the rodent incisor tooth organ. Along the labial surface, inner dental epithelial cells differentiate into ameloblasts that produce enamel extracellular matrix, whereas the epithelia along the lingual surface do not become ameloblasts and do not produce enamel matrix. This study has been designed to compare ultrastructural features of labial versus lingual surfaces, with particular emphasis upon mesenchymal cell shape, the orientation of extracellular matrix collagen, the basal lamina, and the distribution of sulfated glycoconjugates. Critical analyses of the data indicated that different microenvironments exist between epithelia and mesenchyme in the labial versus the lingual surfaces of the developing rodent incisor tooth organ.
mesh_terms: D000818:Animals; D002449:Cell Aggregation; D003804:Dentin / Q000254:growth & development; D004848:Epithelium / Q000378:metabolism / Q000648:ultrastructure; D005260:Female; D006023:Glycoproteins / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism; D006651:Histocytochemistry; D007180:Incisor / Q000254:growth & development* / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013464:Sulfuric Acids / Q000378:metabolism
chemical_list: D006023:Glycoproteins; D006025:Glycosaminoglycans; D013464:Sulfuric Acids; C013786:A73025