A continuous estrogen-progestogen regimen for climacteric complaints. Effects on lipid and lipoprotein metabolism.
The lipid composition of serum and the lipoprotein fractions, very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL) were determined in 26 peri- and postmenopausal women treated with a daily dose of 2 mg 17-beta-estradiol, 1 mg estriol and 1 mg norethisteroneacetate in a continuous regimen for 12 months. A decrease was noted in all serum lipids, triglycerides, cholesterol and phospholipids during treatment. When comparing the lipid values after 3 and 12 months of treatment a tendency was found to approach pretreatment values with time. A reduction of triglycerides in VLDL after 3 months, concomitant with a decrease in HDL-cholesterol, was interpreted as an effect mainly of the progestogen component. A decrease of free cholesterol in LDL was found during treatment. The ratio of LDL-cholesterol/HDL-cholesterol was unaltered when comparing values before vs. after 3 and 12 months of treatment. Decreased levels of HDL-cholesterol and elevated levels of LDL-cholesterol are considered to be risk factors for coronary heart disease. The significance of lipid metabolic effects induced by treatment in the present study on a longterm basis is hard to evaluate in terms of atherogenicity.
D000328:Adult; D002979:Climacteric / Q000187:drug effects*; D004338:Drug Combinations; D004958:Estradiol / Q000627:therapeutic use*; D004964:Estriol / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008593:Menopause / Q000187:drug effects; D008875:Middle Aged; D009640:Norethindrone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000077563:Norethindrone Acetate; D013997:Time Factors
D004338:Drug Combinations; D008055:Lipids; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D004958:Estradiol; D000077563:Norethindrone Acetate; D004964:Estriol; D009640:Norethindrone