Flurbiprofen interaction with single doses of atenolol and propranolol.
In patients with mild hypertension, flurbiprofen in a dose of 100 mg daily for 7 days attenuated the hypotensive effect of a single dose of propranolol 80 mg but not of atenolol 100 mg. The attenuation was not due to an effect on the pharmacokinetic profile of either propranolol or atenolol. An alternative explanation is required.
D000328:Adult; D000450:Aldosterone / Q000097:blood; D001262:Atenolol / Q000037:antagonists & inhibitors* / Q000097:blood / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight; D005260:Female; D005480:Flurbiprofen / Q000009:adverse effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy; D005082:Physical Exertion; D011422:Propionates / Q000009:adverse effects*; D011433:Propranolol / Q000037:antagonists & inhibitors* / Q000097:blood / Q000627:therapeutic use
D011422:Propionates; D000450:Aldosterone; D001262:Atenolol; D005480:Flurbiprofen; D011433:Propranolol