[Comparison of the effects of piracetam and methohexital on cerebral energy metabolism].
Several authors suggest an influence of piracetam on brain energy metabolism. Therefore, we examined the effect of this drug on the levels of high-energy phosphates, glucose, some metabolites of glycolysis and free amino acids in the rat brain under normoxic, ischemic and postischemic conditions. In order to eliminate peripheral effects on the cerebral metabolism the isolated perfused rat brain was used as a model for this study. Methohexital was also administered for demonstrating protective effects on energy metabolism under the experimental conditions employed. The barbiturate, not piracetam, reduced the recovery time of the EEG after 1.5 or 2 min of ischemia. The depletion of energy reserves after the ischemic periods was diminished by methohexital but not by piracetam. The substrate and metabolite levels removed faster to the control levels under methohexital in the postischemic period whereas the piracetam treated brains did not differ from the controls. The subchronical treatment of rats in vivo with piracetam only caused a slightly smaller increase in the cerebral lactate concentration after anoxic periods. These results do not suggest an acute effect of piracetam on rat brain energy metabolism whereas the barbiturate methohexital may protect the brain against ischemic damage in a certain extent.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004569:Electroencephalography; D004594:Electrophysiology; D004734:Energy Metabolism / Q000187:drug effects*; D006019:Glycolysis / Q000187:drug effects; D008297:Male; D008723:Methohexital / Q000494:pharmacology*; D010783:Photometry; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013050:Spectrometry, Fluorescence
D000596:Amino Acids; D011760:Pyrrolidinones; D008723:Methohexital; D010889:Piracetam
Vergleich der Wirkungen von Piracetam und Methohexital auf den zerebralen Energiestoffwechsel.