title: In vivo percutaneous absorption of paraquat from hand, leg, and forearm of humans.
abstract: This study determines the in vivo percutaneous absorption of paraquat in humans. Three skin sites of application were used in a crossover manner for six subjects. The percents of applied dose (9 micrograms/cm2) absorbed were 0.29 +/- 0.2 (SD) for the leg, 0.23 +/- 0.1 for the hand, and 0.29 +/- 0.1 for the forearm. This gives an in vivo absorption rate of 0.03 microgram/cm2 for the 24-h exposure. Paraquat can be absorbed in vivo through the skin of humans; however, it is considered a minimally absorbed chemical.
mesh_terms: D005542:Forearm; D006225:Hand; D006801:Humans; D007866:Leg; D010269:Paraquat / Q000378:metabolism*; D012869:Skin Absorption
chemical_list: D010269:Paraquat