title: [Derivatives of N-hydroxyfenfluramine and their anorectic activity].
abstract: Some derivatives of N-hydroxyfenfluramine substituted at the oxygen atom with benzyl, N-methylcarbamoyl, aliphatic and aromatic acyl groups, were prepared and the anorectic activity was investigated in the rat in comparison with fenfluramine. The most interesting compound was N-(2,6-dimethoxybenzoyloxy)fenfluramine (XIV), which exhibited a LD50 about 5 times higher than that of fenfluramine and a remarkably delayed activity.
mesh_terms: D000818:Animals; D001067:Appetite Depressants / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D005277:Fenfluramine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D051381:Rats
chemical_list: D001067:Appetite Depressants; D005277:Fenfluramine
vernacular_title: Derivati della N-idrossifenfluramina e loro attività anoressica.