Inhibition of fibroblastic cell division by a fraction of structural glycoproteins extracted from rabbit dermis.
A fraction of structural glycoproteins (SGP) extracted from rabbit dermis exerted a concentration-dependent inhibition on the multiplication of normal dermal fibroblasts and of mouse sarcoma fibroblastic cells CCRF S-180 II. The inhibition was fully reversible when the SGP was eliminated from the culture medium.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D003598:Cytoskeletal Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D004261:DNA Replication / Q000187:drug effects; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects; D006023:Glycoproteins / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D007231:Infant, Newborn; D007700:Kinetics; D008297:Male; D051379:Mice; D011817:Rabbits; D012513:Sarcoma, Experimental / Q000473:pathology; D012867:Skin / Q000166:cytology; D012879:Skin Physiological Phenomena
D003598:Cytoskeletal Proteins; D006023:Glycoproteins