The effect of phenylephrine on the accommodative process in man.
Accommodation was measured in a double-blind study on 10 healthy volunteers (22-29 years) before and after the instillation of 0.1%, 1.0% and 10% phenylephrine eye drops. Accommodation decreased exponentially with increasing concentration, reaching an average of 3 dioptres after one drop of 10% phenylephrine. The effect of adding phenylephrine to an atropinized eye was studied in 20 children (3-6 years). The children were randomized to placebo or phenylephrine treatment. The cycloplegic effect of atropine was unchanged in 8 out of 9 placebo-treated children, whereas 5 out of 11 phenylephrine-treated children showed a slight, but not significant, increase in hypermetropia.
D000065:Accommodation, Ocular / Q000187:drug effects*; D000328:Adult; D001285:Atropine / Q000494:pharmacology; D002648:Child; D002924:Ciliary Body / Q000294:innervation; D004311:Double-Blind Method; D006801:Humans; D006956:Hyperopia; D009801:Oculomotor Muscles / Q000294:innervation; D009883:Ophthalmic Solutions; D010656:Phenylephrine / Q000494:pharmacology*; D011897:Random Allocation; D011950:Receptors, Cholinergic / Q000187:drug effects; D012029:Refraction, Ocular
D009883:Ophthalmic Solutions; D011950:Receptors, Cholinergic; D010656:Phenylephrine; D001285:Atropine