title: Condensation of 1-(4,4-dimethyl-2-piperidon-6-yl)-2-propanone with benzaldehyde derivatives.
abstract: Condensation of 1-(4,4-dimethyl-2-piperidon-6-yl)-2-propanone with benzaldehyde derivatives and with cinnamic aldehyde was investigated. Generally, alpha, beta-unsaturated ketones with structures of the (E) -chalcone type were formed. The biological activity of the compounds, particularly given orally, seems to be negligible.
mesh_terms: D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D001522:Behavior, Animal / Q000187:drug effects; D001547:Benzaldehydes / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D001831:Body Temperature / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010880:Piperidines / Q000138:chemical synthesis*; D010881:Piperidones / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D001547:Benzaldehydes; D010880:Piperidines; D010881:Piperidones