Reductive metabolism of halothane in children.
The volatile halothane metabolites, 2-chloro-1,1,1,-trifluoroethane and 2-chloro-1,1-difluoroethylene, were identified in the exhaled breath of ten children during halothane anaesthesia. Although there was considerable variation among children in the concentration and time-course of metabolite exhalation, exhaled concentrations of these metabolites were of a similar magnitude to those reported in adults. This result suggests that the lower incidence of halothane hepatitis in children compared with adults is not due to a poor ability to metabolise halothane by the reductive pathway.
D000769:Anesthesia, Inhalation; D002648:Child; D002675:Child, Preschool; D017402:Chlorofluorocarbons; D005260:Female; D006221:Halothane / Q000378:metabolism*; D006801:Humans; D006846:Hydrocarbons, Halogenated / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D013997:Time Factors
D017402:Chlorofluorocarbons; D006846:Hydrocarbons, Halogenated; C016304:chlorotrifluoroethylene; C018483:2-chloro-1,1-difluoroethylene; D006221:Halothane