title: Sequence-dependant polymorphism of DNA duplex in solutions.
abstract: Raman spectra of six synthetic polydeoxyribonucleotide duplexes with different base sequences have been examined in aqueous solutions with different salt or nucleotide concentrations. Detailed conformational differences have been indicated between B and Z forms of poly[d(G-C)] X poly[d(G-C)], between B forms of poly[d(G-C)] X poly[d(G-C)] and poly[d(G-m5C)] X poly[d(G-m5C)], between A and B forms of poly(dG) X poly(dC), between B and "CsF" forms of poly[d(A-T)] X poly[d(A-T)], between B forms of poly[d(A-U)] X poly[d(A-U)] and poly[d(A-T)] X poly[d(A-T)], and between low- and high-salt (CsF) forms of poly(dA) X poly(dT). The Raman spectrum of calf-thymus DNA in aqueous solution was also observed and was compared with the Raman spectra of its fibers in A, B, and C forms.
mesh_terms: D000818:Animals; D002417:Cattle; D004247:DNA; D008957:Models, Genetic; D009690:Nucleic Acid Conformation; D011089:Polydeoxyribonucleotides; D013059:Spectrum Analysis, Raman; D013329:Structure-Activity Relationship; D013950:Thymus Gland
chemical_list: D011089:Polydeoxyribonucleotides; D004247:DNA