[Results of long-term treatment of cystine lithiasis with D-penicillamine].
Eight patients with cystine stones (7 adults, 1 children) are treated by D-penicillamine since at least 5 years and at the most 9 years. The goal of the treatment is to obtain free cystinuria concentration less than 200 mg/l by the conjunction of a high urine flow and D-penicillamine. Cystinuria is measured by automatic analyser chromatography. In 2 patients, lithiasis got worse and cystinuria remained highly pathologic because bad compliance. In the 6 other cases, no lithiasis recurrence was noted; 5 patients had renal unilateral or bilateral lithiasis before treatment. A partial stone dissolution was obtained in 3 patients and total stone dissolution in 1 patient. Despite important posology often used, D-penicillamine has been remarkably well tolered since the only side effect observed was erythrodermia in 1 case at the beginning of the treatment.
D000328:Adult; D000367:Age Factors; D002675:Child, Preschool; D003553:Cystine / Q000378:metabolism; D003555:Cystinuria / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D007669:Kidney Calculi / Q000209:etiology* / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000627:therapeutic use*
D003553:Cystine; D010396:Penicillamine
Résultats du traitement au long cours de la lithiase cystinique par la D-pénicillamine.