title: Distribution of glucose-6-phosphate dehydrogenase phenotypes in five East Asian population groups.
abstract: 1205 adult males comprising 287 Chinese from Singapore, 448 Thais, 123 Filipinos, 140 Koreans and 207 Taiwanese were investigated for the phenotypic distribution of red cell G6PD by starch-gel electrophoresis. The incidence of the deficient alleles (GdB- and Gd-) was found to be as follows: Chinese - 8%, Thais - 6.7%, Filipinos - 13%, Koreans - 3.5%, and Taiwanese - 11.6%. Low frequency of fast variant of Gd with normal activity was observed in Filipinos (0.8%), Koreans (2.1%) and Taiwanese (0.5%). Two slow variants of Gd alleles with normal activity were detected. The one with 95% mobility was present in Chinese (2.1%), Thais (1.6%), Filipinos (0.8%), Koreans (1.4%) and Taiwanese (1.0%), while the other slower variant was encountered only in Chinese (1.0%) and Thais (0.2%). One instance of Gd B with about 150% enzyme activity was detected in a Thai. Partially deficient fast variant of G6PD was observed in one Thai and one Filipino.
mesh_terms: D000483:Alleles; D002681:China / Q000208:ethnology; D004592:Electrophoresis, Starch Gel; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D006801:Humans; D007723:Korea / Q000208:ethnology; D008297:Male; D010641:Phenotype; D010679:Philippines / Q000208:ethnology; D012846:Singapore; D013624:Taiwan / Q000208:ethnology; D013785:Thailand / Q000208:ethnology
chemical_list: D005954:Glucosephosphate Dehydrogenase