Cytogenetic and genetic effects of subchronic treatments with organophosphorus insecticides.
Male mice (Q strain) received 5 days a week for 7 weeks drinking water containing dichlorvos (2 ppm), dimethoate (0.6 ppm), malathion (8 ppm), methylparathion (0.15 ppm), or trichlorfon (0.5 ppm). At the end of the treatment, no chromosome damage was observed in bone marrow cells, spermatogonia, and primary spermatocytes. Dominant lethal mutation assays were performed to investigate the pre- and postimplantation foetal lethality. Only negative results were obtained.
D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure; D002875:Chromosomes / Q000187:drug effects / Q000648:ultrastructure; D005799:Genes, Dominant / Q000187:drug effects; D005804:Genes, Lethal / Q000187:drug effects; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D009943:Organophosphorus Compounds; D009946:Organothiophosphorus Compounds; D013093:Spermatogonia / Q000648:ultrastructure
D007306:Insecticides; D009153:Mutagens; D009943:Organophosphorus Compounds; D009946:Organothiophosphorus Compounds