The influence of ethanol on synthesis of N-nitrosodimethylamine in vivo and in vitro.
The yield of N-nitrosodimethylamine (NDMA) has been studied in the nitrosation reaction in the presence or in the absence of ethanol. In the experiments in vivo the mice underwent intragastric administration of amidopyrin and sodium nitrite, and in the experiments in vitro dimethylamine (DMA) and sodium nitrite were used. It has been established that both in vivo (in the stomach of mice) and in vitro (in the medium of pure reagents and human gastric juice) ethanol inhibited the reaction of nitrosation by amines in acid media, thus decreasing the yield of NDMA.
D000818:Animals; D004123:Dimethylamines / Q000378:metabolism; D004128:Dimethylnitrosamine / Q000032:analysis / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000494:pharmacology*; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D008815:Mice, Inbred Strains; D012977:Sodium Nitrite / Q000378:metabolism; D013270:Stomach / Q000187:drug effects; D013997:Time Factors
D004123:Dimethylamines; D000431:Ethanol; D012977:Sodium Nitrite; D004128:Dimethylnitrosamine