Nasal mucosa from rat fetuses and neonates metabolizes the nasal carcinogen phenacetin.
In vitro experiments showed that excised ethmoturbinates of late gestational fetuses and neonatal rats have a marked ability to metabolize [14C-ethyl]phenacetin as determined by 14CO2 formation. Autoradiography of fetuses injected in utero with [14C-ethyl]phenacetin on day 22 of gestation showed a selective uptake and binding of radioactivity in the mucosa of the ethmoturbinates.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001345:Autoradiography; D002273:Carcinogens / Q000378:metabolism*; D005260:Female; D005333:Fetus / Q000378:metabolism; D005865:Gestational Age; D066298:In Vitro Techniques; D009297:Nasal Mucosa / Q000196:embryology / Q000378:metabolism*; D009669:Nose Neoplasms / Q000139:chemically induced; D010615:Phenacetin / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; D010615:Phenacetin