[Use of isoptin in the acute period of myocardial infarction (its effect on hemodynamics and myocardial metabolism)].
To study the hemodynamic and metabolic effects of isoptin, the drug was infused intravenously to 15 patients with acute transmural myocardial infarction at a dosage of 0.13-0.17 mg per kg bw. Along with the parameters of the central hemodynamics and the myocardial contractility of the left ventricle, using extraction coefficients the authors determined some parameters of myocardial metabolism. The drug was well tolerated by the patients, virtually did not affect the parameters of myocardial contractility, decreased the work of the heart at the expense of a significant reduction of the after-load and lowered manifestations of the ischemia of the intact myocardium (the coefficient of lactate extraction by the myocardium was found to elevate).
D000328:Adult; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007773:Lactates / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D009206:Myocardium / Q000378:metabolism*; D014700:Verapamil / Q000627:therapeutic use*
D005230:Fatty Acids, Nonesterified; D007773:Lactates; D014700:Verapamil; D005947:Glucose
Primenenie izoptina v ostrom periode infarkta miokarda (vliianie na gemodinamiku i metabolizm miokarda).