title: Placental alkaline phosphatase compared with human placental lactogen and oestriol in high-risk pregnancies.
abstract: Serum levels of placental alkaline phosphatase (PLAP), human placental lactogen (HPL) and oestriol (E3) were investigated in 33 women with high-risk pregnancies. In pregnancies complicated by intrauterine growth retardation (IUGR) low PLAP values were constantly recorded. HPL values showed a similar pattern while E3 levels were between normal mean and the lower limit of -2 SD. A clear differentiation between IUGR and pre-eclampsia was achieved by the simultaneous determination of PLAP and HPL. It is suggested that PLAP determinations may be more informative than E3 to detect placental insufficiency.
mesh_terms: D000328:Adult; D000469:Alkaline Phosphatase / Q000097:blood*; D004964:Estriol / Q000097:blood*; D005260:Female; D005317:Fetal Growth Retardation / Q000097:blood; D006801:Humans; D010920:Placenta / Q000201:enzymology; D010928:Placental Lactogen / Q000097:blood*; D011225:Pre-Eclampsia / Q000097:blood; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood*
chemical_list: D010928:Placental Lactogen; D000469:Alkaline Phosphatase; D004964:Estriol