title: Salicylate prophylaxis in migraine.
abstract: 46 migraine patients and 4 patients suffering from "nonmigrainous" vascular headache were treated with 250 mg salicylate daily for 2 months. Platelet aggregability before and under treatment was measured in all patients and in 10 controls. The results confirm platelet hyperaggregability in migraine patients and a reduction of aggregability under salicylate out provide no evidence of any significant clinical improvement, thus falsifying the hypothesis of migraine as a platelet aggregation disorder.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001241:Aspirin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood / Q000517:prevention & control*; D010974:Platelet Aggregation / Q000187:drug effects; D012459:Salicylates / Q000627:therapeutic use*; D020156:Salicylic Acid; D014653:Vascular Headaches / Q000188:drug therapy
chemical_list: D012459:Salicylates; D020156:Salicylic Acid; D001241:Aspirin