The effect of phenylbutazone on acute hemorrhagic pancreatitis in the rat.
The effect of phenylbutazone on acute experimental pancreatitis was investigated in the rat. Severe necrotico-hemorrhagic pancreatitis was produced by intraductal injection of trypsin. Pretreatment by phenylbutazone did not alter the mortality rate but reduced the severity of pancreatitis as was demonstrated by histological quantification (total score 13.35 +/- 0.80 in treated rats versus 17.67 +/- 0.69 in the control group; P less than 0.01). The protective effect of phenylbutazone seems to be related to the specific anti-inflammatory properties of the drug and not to inhibition of prostaglandin synthesis.
D000208:Acute Disease; D000818:Animals; D005260:Female; D006470:Hemorrhage / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D008297:Male; D010182:Pancreatic Diseases / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D010195:Pancreatitis / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D010653:Phenylbutazone / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D010653:Phenylbutazone