The time course of methanethiol in the rat.
The first order rate constant for the conversion of intraperitoneally administered methanethiol to sulfate in the rat was found to be 0.571 hr-1. The first order rate constant for the urinary excretion of sulfate was 0.0818 hr-1. Thus, the half-life for the metabolism of methanethiol to sulfate was 1.21 hr and for the elimination of sulfate in the urine was 8.47 hr.
D000818:Animals; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013431:Sulfates / Q000652:urine; D013438:Sulfhydryl Compounds / Q000378:metabolism*
D013431:Sulfates; D013438:Sulfhydryl Compounds; C005231:methylmercaptan