title: [Inhibitor interaction in the suppression of ribosomal RNA synthesis in Ehrlich ascites carcinoma cells].
abstract: Kinetic analysis of inhibitory action of papaverine, 2,4-dinitrophenol (DNP) and actinomycin D on RNA synthesis in the intact Ehrlich ascites carcinoma cells has shown that the action of these agents is mediated by their effect on the same step of rRNA synthesis.
mesh_terms: D019297:2,4-Dinitrophenol; D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy / Q000378:metabolism*; D003596:Cytosine / Q000031:analogs & derivatives / Q000627:therapeutic use; D003609:Dactinomycin / Q000627:therapeutic use; D004140:Dinitrophenols / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D007700:Kinetics; D051379:Mice; D009368:Neoplasm Transplantation; D010208:Papaverine / Q000627:therapeutic use; D012334:RNA, Neoplasm / Q000037:antagonists & inhibitors*; D012335:RNA, Ribosomal / Q000037:antagonists & inhibitors*
chemical_list: D004140:Dinitrophenols; D012334:RNA, Neoplasm; D012335:RNA, Ribosomal; D003609:Dactinomycin; D003596:Cytosine; C039855:6-azacytosine; D010208:Papaverine; D019297:2,4-Dinitrophenol
vernacular_title: Vzaimodeĭstvie ingibitorov pri podavlenii sinteza ribosomnoĭ RNK v kletkakh astsitnoĭ kartsinomy Erlikha.