Magnetic fields abolish the enhanced nocturnal analgesic response to morphine in mice.
Mice given morphine displayed diel rhythms in the latency of their behavioral response to placement on a hot plate, there being a several fold increase in their nocturnal reaction times. Exposure to a rotating magnetic field eliminated the day-night analgesia rhythms, reducing over 5-10 days the enhanced nocturnal latencies to those found during the day. The attenuation returned to normal nocturnal levels several days after removal of the rotating magnetic field and could be subsequently re-established by reapplication of the magnetic field condition. It is suggested that these changes in analgesia may reflect alterations in the activity of the pineal gland during exposure to magnetic fields.
D000698:Analgesia; D000818:Animals; D002940:Circadian Rhythm; D006358:Hot Temperature; D008280:Magnetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000494:pharmacology*; D010870:Pineal Gland / Q000502:physiology; D011930:Reaction Time
D009020:Morphine