Preparation and properties of mouse monoclonal antibody (W14A) to human chorionic gonadotropin.
A mouse monoclonal antibody, W14A, has been prepared which reacts with intact human chorionic gonadotropin and its beta-subunit, showing less than 2% cross-reactivity towards the alpha-subunit and 0.5% cross-reactivity towards the beta-subunit of luteinizing hormone. The reagent is suitable for the radioimmunolocalization of choriocarcinoma and trophoblastic teratoma in humans. A preliminary radioimmunoassay has been developed.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000302:isolation & purification; D001932:Brain Neoplasms / Q000175:diagnosis* / Q000556:secondary; D002822:Choriocarcinoma / Q000175:diagnosis* / Q000378:metabolism / Q000556:secondary; D006063:Chorionic Gonadotropin / Q000032:analysis / Q000276:immunology* / Q000378:metabolism; D003429:Cross Reactions; D005260:Female; D006801:Humans; D006825:Hybridomas; D007457:Iodine Radioisotopes; D007553:Isotope Labeling; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D011247:Pregnancy; D011863:Radioimmunoassay; D051381:Rats; D014018:Tissue Distribution; D014594:Uterine Neoplasms / Q000175:diagnosis* / Q000378:metabolism
D000911:Antibodies, Monoclonal; D006063:Chorionic Gonadotropin; D007457:Iodine Radioisotopes