title: Optic nerve sheath meningiomas. Clinical manifestations.
abstract: A retrospective clinical study of optic nerve sheath meningiomas based on 22 patients showed that symptoms most commonly develop in women between the ages of 35 and 60 years. The most common presenting symptoms were decreased vision and transient visual obscurations. In the earliest stages, many patients presented with normal to mildly impaired acuity (despite subjectively decreased vision), optic disc edema and enlargement of the blind spot. Optic disc edema was frequently associated with refractile bodies indicative of chronic swelling. Optic disc edema preceded the development of optic atrophy. Another group of patients presented with a history of longstanding vision loss, visual acuity of 20/200 or worse and optic atrophy. Optociliary shunt vessels were late findings only seen in five patients. The most consistent visual field abnormality was peripheral constriction. Cecocentral scotomas were uncommon. Intracranial involvement was present in five patients. There were two patients with bilateral optic nerve sheath meningiomas without CT evidence of intracranial involvement. Computerized tomography was found to be indispensable in the diagnosis of optic nerve sheath meningiomas and the detection of intracranial involvement.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000792:Angiography; D003118:Color Perception; D003390:Cranial Nerve Neoplasms / Q000150:complications / Q000503:physiopathology*; D005094:Exophthalmos / Q000150:complications; D005128:Eye Diseases / Q000150:complications; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008579:Meningioma / Q000150:complications / Q000503:physiopathology*; D008875:Middle Aged; D009887:Ophthalmoscopy; D009901:Optic Nerve Diseases / Q000150:complications / Q000503:physiopathology*; D011680:Pupil; D014057:Tomography, X-Ray Computed; D014792:Visual Acuity; D014794:Visual Fields