[Abnormalities in the erythrocyte membrane transport of oxalate in calcium oxalate lithogenesis].
The high incidence of a family history and the observation of abnormally high intestinal absorption and urinary excretion of oxalate suggest to consider idiopathic calcium oxalate nephrolithiasis as a metabolic disease characterized by a disorder in oxalate transport. To test this hypothesis, the flux of 14C Oxalate through the membrane of red blood cells was investigated in 24 calcium oxalate stone formers; 18 of the 24 "idiopathic" calcium oxalate stone formers showed an increased oxalate self exchange (75%). Our data seem to support the possibility that "idiopathic" calcium oxalate nephrolithiasis may be considered as a metabolic disease marked by a defect in transmembrane transport of oxalate.
D000328:Adult; D001692:Biological Transport; D002129:Calcium Oxalate / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007669:Kidney Calculi / Q000097:blood* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010070:Oxalates / Q000097:blood* / Q000378:metabolism; D012008:Recurrence
D010070:Oxalates; D002129:Calcium Oxalate
Anomalie du transport érythrocytaire de membrane de l'oxalate dans la lithogénèse oxalo-calcique.