Ethanol preference in mice following acute or chronic ethanol administration.
C57Bl mice, unlike LACG or BALB mice, show a significant preference for 12% (w/v) ethanol solution compared to water. C57Bl mice which have been rendered tolerant to but not dependent upon ethanol by a programme of enforced ethanol drinking lose this preference on withdrawal of compulsory ethanol. Loss of preference also occurs following one or more acute injections of ethanol ( 4ml /kg) and persists in mice 12 weeks following withdrawal. It is suggested that this long-lasting loss of preference has a CNS basis and is not due merely to taste aversion.
D000428:Alcohol Drinking; D000818:Animals; D000431:Ethanol / Q000008:administration & dosage*; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D013045:Species Specificity; D013649:Taste
D000431:Ethanol