An interspecies approach to the investigation of the red cell membrane glucose transporter.
Glucose transport differs in red cells of various species. The following sequence of transport velocities was found: man greater than newborn pig greater than rat, dog greater than cattle greater than pig. No correlation was found between the amount of protein in band 3 and glucose transport activity. By contrast, a very clear peak in the band 4.5 region was found for newborn pigs, whereas adult pigs did not exhibit a corresponding peak in the electrophoresis. Thus further evidence is provided by our investigations in favour of band 4.5 region for glucose transport activity in red cells.
D000818:Animals; D000831:Animals, Newborn; D001457:Anion Exchange Protein 1, Erythrocyte / Q000302:isolation & purification; D001786:Blood Glucose / Q000378:metabolism*; D001798:Blood Proteins / Q000302:isolation & purification; D002352:Carrier Proteins / Q000097:blood* / Q000302:isolation & purification; D002417:Cattle; D004285:Dogs; D004910:Erythrocyte Membrane / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008565:Membrane Proteins / Q000302:isolation & purification; D008970:Molecular Weight; D009004:Monosaccharide Transport Proteins; D033703:Nucleoside Transport Proteins; D051381:Rats; D013045:Species Specificity; D013552:Swine
D001457:Anion Exchange Protein 1, Erythrocyte; D001786:Blood Glucose; D001798:Blood Proteins; D002352:Carrier Proteins; D008565:Membrane Proteins; D009004:Monosaccharide Transport Proteins; D033703:Nucleoside Transport Proteins