[Clinical, immunological and therapeutic research in mesangial immunoglobulin-A glomerulonephritis].
Forty seven patients with IgA glomerulonephritis (GN) were studied. The males predominated among them--the ratio males-female--2,9:1. The first clinical manifestations were macroscopic hematuria (in 2/3 of the cases) or only urine changes--low-degree proteinuria and microscopic erythrocyturia. As early as the establishment--38,2 per cent of the patients had elevated arterial pressure, and it reached, 59,5 per cent during the follow-up period. Anemia was rare. Manifestations of nephrotic syndrome were absent. ESR was normal in 1/3 of the employees or slightly accelerated. Chronic renal insufficiency developed 6,31 per cent of the patient all of them males. Terminal renal insufficiency developed 8 patients. The elevated arterial pressure, proteinuria over 2g/24 h, accelerated ESR, high serum levels of IgA, the longer duration of the disease and higher age of the patients to a certain extent--were unfavourable prognostic criteria. The basic immune deviations of IgA GN are the high serum levels of IgA (in 53,1% of the patients) and to a lower extent of IgG (in 17% of the patients) as well as the reduced serum levels of C3 (in 31,9% of the patients). CIC are not a frequent finding. The percentage of ERF is lower than in the healthy subjects. The treatment with a combination of azathioprine (acenocoumarol, indomethacin or levamisole) has no effect on the clinical manifestations and evolution.
D000074:Acenocoumarol / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis; D001379:Azathioprine / Q000627:therapeutic use; D002908:Chronic Disease; D003176:Complement C3 / Q000032:analysis; D004359:Drug Therapy, Combination; D005260:Female; D005922:Glomerulonephritis, IGA / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007213:Indomethacin / Q000627:therapeutic use; D007978:Levamisole / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation; D013997:Time Factors
D000936:Antigen-Antibody Complex; D003176:Complement C3; D007136:Immunoglobulins; D007978:Levamisole; D000074:Acenocoumarol; D001379:Azathioprine; D007213:Indomethacin
Klinichni, imunologichni i terapevtichni prouchvaniia pri mezangialniia imunoglobulin-A-glomerulonefrit.