Deoxyribonucleoside-3',5'-cyclic silanediyl derivatives: formation and properties.
Formation of 3',5'-O-(dialkylsilanediyl)deoxyribonucleosides was studied. Treatment of deoxythymidine in DMF with bifunctional silylating reagent such as di-t-butyldichlorosilane and diisopropyldichlorosilane in the presence of imidazole gave the expected silanediyl derivatives. The structure was confirmed mainly by NMR spectroscopy. The stability of these cyclic silyl derivatives toward hydrolysis is also described.
D003853:Deoxyribonucleosides / Q000138:chemical synthesis*; D004355:Drug Stability; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D012821:Silanes / Q000138:chemical synthesis*; D012825:Silicon / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
D003853:Deoxyribonucleosides; D007202:Indicators and Reagents; D012821:Silanes; D012825:Silicon