The role of central dopaminergic processes in chemical carcinogenesis.
The effect of chemical carcinogen N-nitrosodiethylamine (NDEA) was studied in white noninbred male rats in a series of experiments. The animals treated with dopamine receptor agonist (apomorphine) showed statistically significant inhibition of carcinogenesis. Dopamine receptor antagonist (haloperidol) showed a tendency to stimulate the carcinogenesis. Also, the modifying effect of NDEA on behavior stereotypy and aggressiveness of experimental animals was found following apomorphine injection at various dosages. The data obtained are discussed from the point of view of the leading role of ANS in homeostatic regulation of the organism and in carcinogenesis.
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001341:Autonomic Nervous System / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D003043:Cocarcinogenesis; D004052:Diethylnitrosamine / Q000037:antagonists & inhibitors*; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008297:Male; D009602:Nitrosamines / Q000037:antagonists & inhibitors*; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects
D009602:Nitrosamines; D004052:Diethylnitrosamine; D006220:Haloperidol; D001058:Apomorphine