title: Antibacterial activities of nitrothiazole against Campylobacter jejuni and Campylobacter coli.
abstract: Niridazole (Ambilhar) and three other newly synthesized nitrothiazole derivatives were highly active against 19 microaerophilic campylobacters (minimum concentration required to inhibit 50% of strains [MIC50], 0.0075 to 0.015 mg/liter). There were, however, considerable differences in the susceptibility among strains tested, and one nitrothiazole derivative was rather inactive (MIC50, 2 mg/liter). Nitroimidazole derivatives, such as metronidazole and tinidazole, were less active (MIC50, 2 and 4 mg/liter, respectively). The nitrofuran derivatives, such as nitrofurazone and nitrofurantoin, were also less active (MIC50, 1 mg/liter). Niridazole and another potent nitrothiazole derivative killed the campylobacters rapidly at low concentrations. In contrast, much higher concentrations of metronidazole were required to achieve bactericidal values.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002167:Campylobacter / Q000187:drug effects*; D002168:Campylobacter fetus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009560:Niridazole / Q000494:pharmacology*; D009581:Nitrofurans / Q000494:pharmacology; D009593:Nitroimidazoles / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D009581:Nitrofurans; D009593:Nitroimidazoles; D009560:Niridazole