[Anti-inflammatory effect and tachyphylaxis of systemic and combined systemic-topical treatment with corticosteroids in the pyrexal erythema test].
On account of clinical experience as well as experimental findings, we noticed subsiding anti-inflammatory and antiproliferative effects of topical corticosteroids after regularly repeated application. Following four-day's oral therapy with methylprednisolone 40 mg daily, the pyrexal erythema test did not reveal any decrease of anti-inflammatory effect in six volunteers. The efficacy of this therapy was similar to that of occlusive topical therapy with 0.25% desoxymethasone ointment. The anti-inflammatory effect of systemic steroid treatment could even be slightly increased by additional topical steroid therapy.
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents; D003899:Desoximetasone / Q000008:administration & dosage / Q000494:pharmacology*; D003907:Dexamethasone / Q000031:analogs & derivatives*; D004359:Drug Therapy, Combination; D004361:Drug Tolerance; D004890:Erythema / Q000188:drug therapy / Q000209:etiology; D006801:Humans; D007275:Injections, Intravenous; D007428:Intradermal Tests / Q000379:methods; D008070:Lipopolysaccharides / Q000276:immunology; D008775:Methylprednisolone / Q000008:administration & dosage / Q000494:pharmacology*; D012475:Salmonella; D012882:Skin Tests / Q000379:methods
D000893:Anti-Inflammatory Agents; D008070:Lipopolysaccharides; D003899:Desoximetasone; D003907:Dexamethasone; D008775:Methylprednisolone
Antientzündlicher Effekt und Tachyphylaxie bei systemischer und kombinierter systemisch-topischer Kortikosteroidbehandlung im Pyrexal-Erythem-Test.