Nimesulide and antibiotics in the treatment of acute urinary tract infections.
A double-blind parallel 20-day trial was carried out in 40 patients with acute infectious inflammation of the urogenital tract to compare the effectiveness of antibiotic treatments alone or with concomitant use of a new non-steroidal antiinflammatory drug, 4-nitro-2-phenoxymethane sulfonanilide (nimesulide) 200 mg/d. During the course of the treatment, nimesulide plus antibiotics induced a significantly greater and more rapid improvement of the treated patients in comparison with antibiotics plus placebo, in case of prostate swelling, redness, oedema, compulsion, pollakiuria, nycturia and body temperature. The assessment on efficacy expressed by the investigator and the patient was significantly better in the case of antibiotic plus nimesulide as compared to the antibiotic treatment alone (p less than 0.01). With the improvement of clinical complaints, there resulted a significant reduction of erythrocyte sedimentation rate and of white blood cell count. In the antibiotic plus nimesulide treatment group, the laboratory parameters used as a control for the tolerability of the drug did not show any significant variation. There were no side-effects reported.
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001772:Blood Cell Count; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013449:Sulfonamides / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000097:blood / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D013449:Sulfonamides; C012655:nimesulide