Polymorphism of C3 component of complement in the Polish population. I. Population and family studies.
In a sample of the Polish population numbering 4741 subjects, the three common types C3S, C3F and C3FS and 15 phenotype variants were found with frequencies 0.0046. The frequencies of C3S and C3F genes determining the common types were 0.8227 and 0.1750, respectively. Examination of 40 newborns and their mothers has revealed that C3 types are formed during the fetal life. The results of studies on 76 families with 157 children and 2332 mother-child pairs have confirmed that 3C3 types are determined by a single genetic locus in which codominant autosomal alleles are situated.
D000328:Adult; D000483:Alleles; D003176:Complement C3 / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005799:Genes, Dominant; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011044:Poland; D011110:Polymorphism, Genetic
D003176:Complement C3