Effects of an anabolic steroid on acute uremia in the dog.
Four groups of dogs made acutely uremic were treated with placebo, 0.5 mg/kg, 1.0 mg/kg, and 1.5 mg/kg of an anabolic steroid (3-oxo-delta 1,4 androstadiene-17 beta-ol-undecylenate). Pretreatment and posttreatment measurements of food intake, body weight, PCV, serum creatinine concentration, plasma albumin concentration, nitrogen balance, lean body mass, and limb circumference did not indicate any beneficial effect of this drug in this model of acute uremia.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004435:Eating / Q000187:drug effects; D005260:Female; D006400:Hematocrit / Q000662:veterinary; D008297:Male; D010919:Placebos; D012709:Serum Albumin / Q000378:metabolism; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D014511:Uremia / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*
D010919:Placebos; D012709:Serum Albumin; D013739:Testosterone; D003404:Creatinine; C001371:boldenone undecylenate