Cisplatin-induced autonomic neuropathy.
A 57-year-old man with bronchogenic squamous cell carcinoma developed an autonomic neuropathy following treatment with a chemotherapy combination which included cisplatin. The autonomic neuropathy resolved following discontinuation of the cisplatin and treatment with dextroamphetamine. The following case represents a patient with bronchogenic carcinoma treated with cyclophosphamide, doxorubicin, and cisplatin, who developed a severe autonomic neuropathy following chemotherapy administration. This is the first report of cisplatin-associated autonomic neuropathy to appear in the literature.
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001342:Autonomic Nervous System Diseases / Q000139:chemically induced* / Q000188:drug therapy; D002283:Carcinoma, Bronchogenic / Q000188:drug therapy; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000008:administration & dosage; D003913:Dextroamphetamine / Q000627:therapeutic use; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male
D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin; D003913:Dextroamphetamine