Restoration of fertility with gonadotropin and bromocriptine in a hypogonadal man after removal of macroprolactinoma.
A case of male hypogonadism after removal of macroprolactinoma was successfully treated with gonadotropin. A 35-year-old man treated surgically for pituitary adenoma had elevated plasma prolactin and impaired pituitary function after the operation. He was on replacement of hydrocortisone, levothyroxine and testosterone depot along with bromocriptine. Normal plasma testosterone levels were achieved with HCG, 3,000 IU three times a week. The addition of 75 IU of FSH daily restored spermatogenesis and the sperm count reached the fertile range at the 11th month. Doses of HCG and FSH were cut in half at the 10th month without affecting the plasma testosterone levels. His wife was impregnated at the 12th month and gave birth to a normal baby girl.
D000328:Adult; D001971:Bromocriptine / Q000627:therapeutic use*; D006062:Gonadotropins / Q000627:therapeutic use*; D006801:Humans; D007006:Hypogonadism / Q000150:complications*; D007248:Infertility, Male / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D010911:Pituitary Neoplasms / Q000150:complications / Q000378:metabolism* / Q000601:surgery; D011388:Prolactin / Q000378:metabolism*; D013076:Sperm Count; D013739:Testosterone / Q000097:blood
D006062:Gonadotropins; D001971:Bromocriptine; D013739:Testosterone; D011388:Prolactin