[Mutagenic action of tritium on the germ cells of male mice. II. The genetic damages in stem spermatogonia induced by tritium oxide and gamma radiation].
The frequency of reciprocal translocations (RT) induced by single injection of tritiated water (THO) (3.3; 6.3 and 12.6 MBq/g) or by referent 137Cs gamma irradiation was studied. The absorbed doses in testis were: 1; 2 and 4 Gr. The frequency of RT per 100 cells were 0.4; 1.1 and 2.5 after THO administration, and 0,5; 0.9 and 1.2 after single exposure to gamma irradiation, respectively. The RBE of tritium increased from 1 at the dose of 1 Gr to 2, at the dose of 4 Gr.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004583:Electrons; D005720:Gamma Rays; D005799:Genes, Dominant / Q000528:radiation effects; D005804:Genes, Lethal / Q000528:radiation effects; D008297:Male; D051379:Mice; D009154:Mutation; D013077:Sperm Head / Q000528:radiation effects / Q000648:ultrastructure; D013093:Spermatogonia / Q000528:radiation effects* / Q000648:ultrastructure; D013094:Spermatozoa / Q000528:radiation effects*; D013234:Stem Cells / Q000528:radiation effects* / Q000648:ultrastructure; D013997:Time Factors; D014178:Translocation, Genetic / Q000528:radiation effects*; D014316:Tritium / Q000494:pharmacology*; D014867:Water / Q000494:pharmacology*
D014867:Water; D014316:Tritium; C033961:tritium oxide
Mutagennoe dĭestvie tritiia na polovye kletki samtsov myshi. Soobshchenie II. Geneticheskie povrezhdeniia v stvolovykh spermatogoniiakh, indutsirovannye okis'iu tritiia i gamma-izlucheniem.