title: Anti-inflammatory activity of Eryngium maritimum L. rhizome extracts in intact rats.
abstract: The administration of rough hydrophilic extract of Eryngium maritimum L. to intact rats inhibits carrageenin induced paw oedema, but it is inactive against cotton pellet granuloma; moreover, the extract does not reduce the weight of thymus, adrenals and spleen. These data show that the anti-inflammatory effect of E. maritimum extract is unlikely to be produced by a steroid-like compound or to be a consequence of adrenal stimulation. Further fractionation of total hydrophilic extract showed that the anti-inflammatory activity is retained by a sub-alkaline fraction.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents; D001241:Aspirin / Q000494:pharmacology; D002351:Carrageenan; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D005528:Foot; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy; D006854:Hydrocortisone / Q000494:pharmacology; D007558:Italy; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D002351:Carrageenan; D001241:Aspirin; D006854:Hydrocortisone