Supraventricular tachycardia. A probable complication of platinum treatment.
A 51-year-old woman with carcinoma of the ovary developed two episodes of supraventricular tachycardia during two consecutive cycles of combination chemotherapy. Both episodes occurred on day 5 of the 5-day continuous infusion schedule of cis-platinum. Underlying causes known to produce supraventricular tachycardia were ruled out. The possibility of platinum-related cardiac toxicity is discussed.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000008:administration & dosage; D003536:Cystadenocarcinoma / Q000188:drug therapy; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects; D004342:Drug Hypersensitivity / Q000209:etiology; D004562:Electrocardiography; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy; D013610:Tachycardia / Q000139:chemically induced*
D004317:Doxorubicin; D003520:Cyclophosphamide; D002945:Cisplatin; D005472:Fluorouracil