Physico-chemical properties and stabilities of a new positive inotropic agent, 3,4-dihydro-6-[4-(3,4-dimethoxybenzoyl)-1-piperazinyl] -2(1H)-quinolinone (OPC-8212).
3,4-Dihydro-6-[4-(3,4- dimethoxybenzoyl )-1-piperazinyl]-2(1H)- qu inolinone ( OPC -8212), a new positive inotropic agent, was examined to clarify its physico-chemical properties, i.e. elemental analysis, melting point, spectra (UV, IR, NMR, MS), X-ray diffraction pattern, thermal analysis, solubilities, pKa, partition coefficient and chromatography (HPLC, TLC). Some degradation products of OPC -8212 were identified in acidic and basis solutions. OPC -8212 was determined by nonaqueous titration.
D002316:Cardiotonic Agents / Q000032:analysis; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D011719:Pyrazines; D011804:Quinolines / Q000032:analysis; D012995:Solubility
D002316:Cardiotonic Agents; D011719:Pyrazines; D011804:Quinolines; C041667:vesnarinone