[Estrogen and progesterone hormonal receptors in meningioma. Results and comments apropos of 26 cases].
In the first part: the charcoal-assay method was briefly described (sensitivity: PR = 10 fmol/mg protein, ER = 5 fmol/mg protein), and criteria for the validity of this method were analysed: sufficient amount of tumor (150-200 mg) minimum protein concentration should be 2 mg/ml choice of a suitable labeled hormone plotting of Scatchard curve with at least 4 aligned points and systematic control of the dissociation constant (Kd) systematic assay of a reference cytosol. In the second part: the results were analysed and compared with those of various authors: PR were positive in 13 out of 23 determinations (56,5%), 12-230 fmol/mg protein (mean: 93 fmol/mg protein) ER were positive in 2 out of 25 determinations (8%), 5 and 16 fmol/mg protein. Only one tumor showed positive ER and PR and no significant difference was shown between ER and PR results on male and female patients. In conclusion, the physiopathological significance of ER and PR is discussed and a new approach to treatment of some meningiomas is mentioned.
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000032:analysis* / Q000473:pathology / Q000503:physiopathology; D008579:Meningioma / Q000032:analysis* / Q000473:pathology / Q000503:physiopathology; D008875:Middle Aged; D011960:Receptors, Estrogen / Q000032:analysis* / Q000502:physiology; D011980:Receptors, Progesterone / Q000032:analysis* / Q000502:physiology
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone
Les récepteurs hormonaux d'oestrogènes et de progestérone dans les méningiomes. Résultats et réflexions à propos de 26 cas.