Pharmacokinetics and bacteriological efficacies of apalcillin and cefpiramide in experimental pneumococcal meningitis.
Rabbits with experimentally induced pneumococcal meningitis were given single 25-mg/kg doses of apalcillin or cefpiramide. Mean percentages of the drug concentration in cerebrospinal fluid versus that in blood serum were 7.6% with apalcillin and 3.9% with cefpiramide. Bactericidal activity in cerebrospinal fluid resulted in mean reductions of from 4 to 5 log10 CFU/ml, and cerebrospinal fluid cultures became sterile for four of six animals treated with each drug.
D000667:Ampicillin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D000818:Animals; D002511:Cephalosporins / Q000378:metabolism* / Q000627:therapeutic use; D007700:Kinetics; D008297:Male; D008586:Meningitis, Pneumococcal / Q000188:drug therapy*; D009287:Naphthyridines; D011817:Rabbits; D013296:Streptococcus pneumoniae / Q000187:drug effects
D002511:Cephalosporins; D009287:Naphthyridines; C012122:apalcillin; D000667:Ampicillin; C036666:cefpiramide