Changes of plasma bile acid levels and their clinical significance in drug-induced liver injury.
Previously, the author described bile acid levels in plasma of patients with liver diseases and their clinical significance (8). This paper gives characteristics of changes in bile acid levels and composition in blood plasma of patients with drug-induced liver injury compared with those of other liver diseases and healthy controls. Based on the results, it can be said that bile acid levels in plasma can be utilized as a diagnostic procedure in drug-induced liver injury and the author also wants to stress that we must direct our attention to the appearance of lithocholic acid in plasma of patients with drug-induced liver injury because the appearance of lithocholic acid in plasma was one of the outstanding findings in this study.
D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001647:Bile Acids and Salts / Q000097:blood*; D056486:Chemical and Drug Induced Liver Injury; D002779:Cholestasis / Q000097:blood; D006525:Hepatitis, Viral, Human / Q000097:blood; D006801:Humans; D008107:Liver Diseases / Q000097:blood
D001647:Bile Acids and Salts; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase