title: Delayed aggregation of proteoglycans in adult human articular cartilage.
abstract: The biosynthesis and macromolecular organization of proteoglycans was studied in explants of adult human articular cartilage. In a series of pulse-chase experiments, labelling with (35S)sulphate, it was shown that the proteoglycan monomer is synthesized as a precursor that has a low affinity for hyaluronic acid. These findings suggest a possible mechanism by which the rate of incorporation of proteoglycans into the extracellular matrix may be controlled.
mesh_terms: D002358:Cartilage, Articular / Q000378:metabolism*; D046508:Culture Techniques; D005109:Extracellular Matrix / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000378:metabolism; D006801:Humans; D046911:Macromolecular Substances; D008970:Molecular Weight; D011509:Proteoglycans / Q000378:metabolism*; D013997:Time Factors
chemical_list: D006025:Glycosaminoglycans; D046911:Macromolecular Substances; D011509:Proteoglycans