title: Cephabacins, new cephem antibiotics of bacterial origin. II. Isolation and characterization.
abstract: Fifteen components of new antibiotics, cephabacins, were isolated from the culture filtrates of Lysobacter lactamgenus YK-90, Xanthomonas lactamgena YK-280 and X. lactamgena YK-278. They were purified by column chromatography using cation-exchange resins, activated carbon, high porous resins and cation-exchange Sephadex and by preparative reverse-phase HPLC. The basic, water-soluble antibiotics were characterized as having a cephem skeleton and oligopeptide(s) as a side chain constituent from their spectroscopic analyses and amino acid analyses.
mesh_terms: D002511:Cephalosporins / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D009682:Magnetic Resonance Spectroscopy; D014974:Xanthomonas / Q000378:metabolism
chemical_list: D002511:Cephalosporins; C044529:cephabacins