title: Ethanol depresses inferior olive neurones and reduces Purkinje cell complex spike activity evoked by cerebral cortical stimulation.
abstract: Complex spike activity was evoked in cerebellar Purkinje cells by submaximal stimulation of the sensory cerebral cortex of urethane anaesthetised rats. Ethanol (1.5 g/kg, i.v. over 10 min) produced a parallel decrease in spontaneous and cerebral cortex-evoked CS activity. The spontaneous firing rate of inferior olive neurones was decreased by ethanol administered intravenously (1.5 g/kg, over 10 min) or locally by micropressure ejection. Thus, the decrease in CS activity produced by ethanol is due to a depression of inferior olive neurones, possibly by a direct action of ethanol on these neurones.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002540:Cerebral Cortex / Q000502:physiology*; D004558:Electric Stimulation; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D011689:Purkinje Cells / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000431:Ethanol