title: Potential hazards of NMR imaging. No evidence of the possible effects of static and changing magnetic fields on cardiac function of the rat and guinea pig.
abstract: Clinical proton NMR imaging uses magnetic field strengths in the range 0.1 to 0.5 T. In addition to the large static magnetic field, patients are exposed to magnetic field gradients during imaging and under extreme conditions, such as power failure or quenching, the field may collapse precipitously. A potential source of hazard to patients under these conditions is the induction of thoracic currents which may trigger ventricular fibrillation. In the present experiments, a 0.16 T resistive magnet with a time constant of 60 ms, powered by a programmable power supply, was used to examine any possible effects of static and changing magnetic field on the ECG and arterial blood pressure of anesthetized rats and guinea pigs. Animals were exposed to the following field conditions: static fields of 0.16 T; sine, triangular, and square wave modulated fields from 0.1 to 2 Hz; rapid field switches in excess of 2.0 T/s for 25 ms timed to occur at different stages of the cardiac cycle, including the vulnerable period during ventricular repolarization; and AC fields of 50 Hz. No change was observed in the blood pressure, heart rate, or ECG under any of the field conditions examined.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D004562:Electrocardiography; D004574:Electromagnetic Fields / Q000009:adverse effects*; D055590:Electromagnetic Phenomena / Q000009:adverse effects*; D006168:Guinea Pigs; D006321:Heart / Q000502:physiology*; D006339:Heart Rate; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats