Inhibition of granulocyte-macrophage (GM) colony formation by sera of patients with neoplasma of digestive tract in the course of surgical treatment.
The effect of sera from patients with neoplasm of the digestive tract obtained during intervention has been tested on granulocyte-macrophage (GM) colony formation. Independently of the source of blood (peripheral or tumour draining vein) and the time of sampling (during or 2-3 weeks after operation) the tested sera suppressed GM colony formation. The highest decrease was caused by blood sampled from the vein draining the tumour. It is concluded that tumour cells may be a source of the GM colony formation inhibitory activity. The possible character of the activity is discussed.
D000328:Adult; D000368:Aged; D004067:Digestive System Neoplasms / Q000097:blood* / Q000601:surgery; D005260:Female; D006098:Granulocytes / Q000502:physiology*; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D008264:Macrophages / Q000502:physiology*; D008297:Male; D008875:Middle Aged