title: [Endocurie therapy of breast cancer I. Indication and value of the implantation of iridium 192 within the total concept of conservative organ-preserving therapy of breast cancer].
abstract: The goal of conservative surgery is reduction of macroscopic tumour masses and lymph node sampling. In combination with adequate radiotherapy the local control rates reported by some authors are as good as those of radical surgery. Interstitial implantation of Ir192 offers the possibility of applying very high radiation doses without early complications and late effects. This method could also be carried out effectively as primary treatment, even for locally advanced stages. The recurrence rates for early breast cancer in a few reports are lower than 10%. Combined with systemic therapy the treatment results even in T3 and T4 lesions are relatively satisfactory. These treatment concepts remain to be tested in controlled clinical trials.
mesh_terms: D001918:Brachytherapy; D001943:Breast Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D007495:Iridium / Q000627:therapeutic use*; D008017:Life Expectancy; D009364:Neoplasm Recurrence, Local / Q000601:surgery; D011829:Radiation Dosage; D011868:Radioisotopes / Q000627:therapeutic use*
chemical_list: D011868:Radioisotopes; D007495:Iridium
vernacular_title: Endocurietherapie des Mammakarzinoms I. Indikation und Stellenwert der Implantation von Iridium192 innerhalb des Gesamtkonzepts der konservativen organerhaltenden Therapie des Brustkrebses.