title: [Persistent influenza virus infection in a MDCK cell culture].
abstract: A model of persistent influenza infection (PII) induced by influenza A/Victoria/35/72 (H3N2) virus in MDCK cell culture has been constructed. The model was observed for 165 days. It was characterized by the lack of visible signs of virus reproduction, a low number of antigen-containing cells (0.02-0.05%), irregular virus isolation (at 20, 28, 32, 44, 52, 62, 92, 135, 148, 158 days after primary inoculation) which was possible only with special methods. Interferon and DIP were found not to be the factors responsible for maintenance of PII in MDCK culture.
mesh_terms: D000818:Animals; D002460:Cell Line; D002642:Chick Embryo; D003673:Defective Viruses / Q000302:isolation & purification / Q000502:physiology; D009980:Influenza A virus / Q000302:isolation & purification / Q000502:physiology; D009976:Orthomyxoviridae Infections / Q000382:microbiology*; D013696:Temperature; D013997:Time Factors; D014762:Viral Interference; D014776:Virus Cultivation / Q000379:methods; D014779:Virus Replication
vernacular_title: Persistentnaia infektsiia virusa grippa v kul'ture kletok MDCK.