Effect of stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine on host resistance to Corynebacterium kutscheri infection in cortisone-treated mice.
Opportunistic corynebacteriosis was induced successfully by infection with Corynebacterium kutscheri in cortisone-treated mice and the ability of stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine derivatives in phosphate buffered saline (PBS) solution or encapsulated into liposomes for restoring impaired resistance was examined. 6-O-Stearoyl-N-acetylmuramyl-L-alanyl-D-isoglutamine (L18-MDP) in liposomes and N alpha-acetyl muramyl-L-alanyl-D-isoglutaminyl-N epsilon-stearoyl-L-lysine (MDP-Lys-L18) both in PBS solution and in liposomes were shown to restore depressed resistance to infection of C. kutscheri when injected intravenously before infection. Treatment with L18-MDP in cortisone-treated mice inhibited growth of C. kutscheri in the liver and kidney for as long as three days after infection.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D003348:Cortisone / Q000494:pharmacology*; D003354:Corynebacterium Infections / Q000276:immunology*; D007113:Immunity, Innate / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D000119:Acetylmuramyl-Alanyl-Isoglutamine; C035295:6-O-stearoyl-N-acetylmuramyl-alanylisoglutamine; C036866:romurtide; D003348:Cortisone