Fetal lamb clearance of morphine as determined by high performance liquid chromatography with electrochemical detection.
Morphine clearance from plasma was determined during constant rate drug infusion in 10 late gestation fetal lambs. Clearance, 65 +/- 6 ml.min-1.kg-1, was independent of infusion rate. Morphine clearance was a first order process in the dose range studied.
D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D009020:Morphine / Q000097:blood*; D011247:Pregnancy; D012756:Sheep
D009020:Morphine