Plasma concentrations of theophylline and quinine in healthy volunteers following oral administration of a fixed drug combination.
Theophylline and quinine plasma concentrations were determined in 4 healthy volunteers following oral administration of two tablets of Limptar . According to the recommended dose schedule the second tablet was administered 3 h after the first tablet. Peak concentrations of theophylline and quinine in the plasma were observed at 5.4 h (theophylline) and 5.1 h (quinine), respectively, following administration of the first tablet. Half-life of theophylline ranged from 7.2 to 15.4 h (9.4 +/- 4.4 h; mean +/- SD) and that of quinine from 5.4 to 27.2 h (14.4 +/- 9.2 h). Peak concentrations of theophylline in the plasma (7.5 +/- 1.6 micrograms/ml) are below those which are thought to produce concentration-dependent side effects. Besides the superior therapeutic efficacy of the combination of quinine and theophylline compared to that of quinine alone, this combination seems to be favourable also from a pharmacokinetic point of view.
D000284:Administration, Oral; D000328:Adult; D000628:Aminophylline / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D004338:Drug Combinations / Q000008:administration & dosage / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008297:Male; D011803:Quinine / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism*; D013806:Theophylline / Q000097:blood*
D004338:Drug Combinations; D000628:Aminophylline; C025678:Limptar; D011803:Quinine; D013806:Theophylline