Synthesis and pharmacological properties of the products of condensation of tryptamine derivatives with pyridoxal.
Four new derivatives of 1,2,3,4-tetrahydro-beta-carboline 2a--d were synthetized with the pyridoxal moiety in position 1; there were also obtained four Schiff bases 1a--d which are intermediate products in this synthesis. Schiff bases 1a--d revealed a sedative and analgesic action, and compound 1b also had potential antidepressive properties. The derivatives of tetrahydro-beta-carboline 2a--d were inactive in the carried out tests.
D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D000928:Antidepressive Agents / Q000138:chemical synthesis; D001763:Blepharoptosis / Q000139:chemically induced; D001831:Body Temperature / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004357:Drug Synergism; D007928:Lethal Dose 50; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011730:Pyridoxal / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D012110:Reserpine / Q000037:antagonists & inhibitors; D012545:Schiff Bases / Q000138:chemical synthesis; D012640:Seizures / Q000139:chemically induced; D014363:Tryptamines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000700:Analgesics; D000928:Antidepressive Agents; D012545:Schiff Bases; D014363:Tryptamines; D011730:Pyridoxal; D007980:Levodopa; D012110:Reserpine