Immunity against genital infection by Histophilus ovis in rams.
Rams have been immunized against an infection of their genitalia by Histophilus ovis. An alum-precipitated antigen and an antigen plus Freund's complete adjuvant proved equally effective. An injection of live H. ovis into the epididymal tissue proved to be a better method of challenging immunity than an injection into the vas deferens. It was shown that cell-mediated immunity, as evidenced by tests for lymphocyte transformation, the presence of a macrophage migration inhibition factor and a delayed hypersensitivity skin reaction did not play a role in the resistance, nor did specific IgG antibodies have any protective influence. It was shown that neutrophils play a cardinal role in the immunity against H. ovis infection in so far as they phagocytize and destroy the organisms and are attracted to them by chemotaxis in immune animals.
D000276:Adjuvants, Immunologic; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D002634:Chemotaxis, Leukocyte; D005832:Genital Diseases, Male / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D006190:Haemophilus / Q000276:immunology*; D006192:Haemophilus Infections / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D007111:Immunity, Cellular; D007114:Immunization / Q000662:veterinary*; D008297:Male; D009504:Neutrophils / Q000276:immunology; D010587:Phagocytosis; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology* / Q000517:prevention & control
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial