title: An assessment of ciclazindol in stimulating thermo-genesis in human volunteers: a detailed metabolic study.
abstract: Seven normal-weight young men lived for seven weeks in a metabolic unit on a diet (12 per cent protein, 30 per cent fat) equivalent in energy content to that calculated from a previous seven-day weighted intake. Three different doses of ciclazindol and a placebo were given for a week each on a Latin Square double-blind cross-over basis. At the end of each experimental week the subject occupied a whole-body indirect calorimeter at 26 degrees C for 36 h. Heart rate was monitored and a strict time-table of activity defined. Appetite and mood were assessed throughout the study period. Faecal and urinary energy excretion were used to define metabolisable energy intake. Multiple regression analysis showed a small but dose-dependent increase in energy output with the drug. This effect was present during the daytime when the subject was active and fed but not at night when he was lying still in bed. Heart rate rose significantly in both the day and night, and sleep was shortened. Appetite was suppressed; however, all but one subject maintained the diet. In conclusion, ciclazindol in man affects appetite, has a general arousal and a small thermogenic effect.
mesh_terms: D000328:Adult; D000339:Affect / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects*; D002151:Calorimetry; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004341:Drug Evaluation; D002149:Energy Intake; D004734:Energy Metabolism / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006815:Hunger / Q000187:drug effects; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D012044:Regression Analysis; D012890:Sleep / Q000187:drug effects
chemical_list: D007211:Indoles; C009990:ciclazindol