A comparison between the efficacy of thiabendazole and febantel on experimental trichinellosis in rats.
Febantel at a dose level of 5 mg kg-1 had a lethal efficacy of 54.1% against the adult worm and 69.5% against the migrating larvae of Trichinella spiralis in rats. When administered at 15 mg kg-1, it demonstrated lethal effects of 94.4, 92.5 and 74.7% against adult, young and encysted larvae, respectively. Infected rats treated with 300 mg kg-1 died. Thiabendazole had efficiencies of 96.4 and 83.3% against intestinal and migrating early muscle phases, respectively, and was 42% effective against the encysting phase.
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D009132:Muscles / Q000469:parasitology; D051381:Rats; D011919:Rats, Inbred Strains; D013827:Thiabendazole / Q000627:therapeutic use*; D014234:Trichinella / Q000187:drug effects* / Q000254:growth & development; D014235:Trichinellosis / Q000188:drug therapy* / Q000469:parasitology
D000871:Anthelmintics; D006146:Guanidines; D013827:Thiabendazole; C017309:febantel