Metabolism of tenoxicam in rats.
The structures of six metabolites of tenoxicam in rats (2 mg/kg, orally), elucidated by physicochemical analyses or the reverse-isotope dilution method, were 5'-hydroxytenoxicam (5% dose), 3-(methylsulphamoyl)-2-thiophenecarboxylic acid (9% dose), and the C-7 or C-8 O-glucuronide of tenoxicam (30% dose). The mechanism of formation of N-methylthiophenesulphimide, a possible precursor of 3-(methylsulphamoyl)-2-thiophenecarboxylic acid from tenoxicam, is discussed.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism*; D001711:Biotransformation; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D010894:Piroxicam / Q000031:analogs & derivatives*; D051381:Rats; D011919:Rats, Inbred Strains; D013843:Thiazines / Q000378:metabolism*
D000893:Anti-Inflammatory Agents; D013843:Thiazines; D010894:Piroxicam; C032801:tenoxicam