In vitro release of meclozine hydrochloride from lipophilic suppository bases with or without tensides.
Meclozine hydrochloride suppositories were prepared with lipophilic bases, and the release rate of the drug from molten suppositories was investigated in vitro. Among various suppository bases, the highest rate was obtained when Witepsol H 15 was used. The release rates were affected if nonionic tensides (Tween 20 and 80) were incorporated. In comparison to the tensides-free suppositories, the rates obtained with suppositories containing 5, 20 and 30% of tensides were higher, approximately the same, and lower (respectively). The results were interpreted in terms of the micellar solubilization of the drug with nonionic tensides.
D000818:Animals; D002626:Chemistry, Pharmaceutical; D003956:Dialysis; D004058:Diffusion; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects; D007700:Kinetics; D008468:Meclizine / Q000008:administration & dosage* / Q000032:analysis; D011136:Polysorbates / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility; D013488:Suppositories
D011136:Polysorbates; D013488:Suppositories; D008468:Meclizine