Dipeptides delay the onset of morphine withdrawal in the mouse.
The effect of dipeptides was studied on naloxone-precipitated morphine withdrawal in the mouse. In accordance with previous data, s.c. treatment with Z-prolyl-D-leucine delayed the onset of withdrawal jumpings . Replacement of L-proline by L-glutamate or L-pyroglutamate resulted in dipeptides which were more potent in morphine withdrawal than was Z-prolyl-D-leucine.
D000704:Analysis of Variance; D000818:Animals; D004151:Dipeptides / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D051379:Mice; D009020:Morphine / Q000633:toxicity*; D009021:Morphine Dependence / Q000188:drug therapy; D009270:Naloxone; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D013375:Substance Withdrawal Syndrome / Q000517:prevention & control*
D004151:Dipeptides; C041765:pyroglutamylleucine; D009270:Naloxone; C018170:prolylleucine; D009020:Morphine; D011761:Pyrrolidonecarboxylic Acid