About the effect of risk factors on the structure and the proliferation of arterial wall cells. Part 1: Changes in structure and proliferation of cultivated aortic smooth muscle cells from hypertensive-diabetic rats.
In cultivated aortic smooth muscle cells (SMC) from normal or hypertensive-diabetic rats respectively, two types of cells, small SMC and large ones, were observed. The differences between the surface areas, form factors and nucleus-plasma relations of the small and the large cells, measured by morphometric methods are evident. The ratio of small to large cells originating from the normal group was 87%: 13%, and of those originating from the hypertensive-diabetic group 76%: 24%. The percentages of polynuclear cells from the normal group were 3.9% and from the hypertensive-diabetic group 6.1%. The small cells from hypertensive-diabetic rats proliferated faster (3H-thymidine labeling index 23.7%) than those from the control rats (3H-thymidine labeling index 12.9%). Their large cells showed on the contrary a trend to slower proliferation.
D000818:Animals; D001011:Aorta / Q000166:cytology / Q000473:pathology* / Q000648:ultrastructure; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D001835:Body Weight; D002452:Cell Count; D002455:Cell Division; D002478:Cells, Cultured; D003921:Diabetes Mellitus, Experimental / Q000473:pathology* / Q000503:physiopathology; D006977:Hypertension, Renal / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000473:pathology* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D012306:Risk
D001786:Blood Glucose