title: Carcinogenicity in mice of mutagenic compounds from glutamic acid and soybean globulin pyrolysates.
abstract: 2-Amino-6-methyldipyrido[1,2-a:3',2'-d]imidazole and 2- aminodipyrido [1,2-a:3',2'-d]imidazole, potent mutagens from glutamic acid pyrolysate, were given orally to CDF1 mice of both sexes at concentrations of 0.05% in pellet diet. 2-Amino-3-methyl-9H-pyrido[2,3-b]indole and 2-amino-9H-pyrido[2,3-b]indole, potent mutagens from soybean globulin pyrolysate, were given to CDF1 mice of both sexes at concentrations of 0.08%. Hepatocellular carcinomas and hemangioendothelial sarcomas in the brown adipose tissue were induced in high incidence by all these compounds.
mesh_terms: D000818:Animals; D002243:Carbolines / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D005260:Female; D005916:Globulins; D007093:Imidazoles / Q000633:toxicity*; D007211:Indoles / Q000633:toxicity*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000473:pathology*; D012737:Sex Factors; D013025:Glycine max
chemical_list: D002243:Carbolines; D002273:Carcinogens; D005916:Globulins; D007093:Imidazoles; D007211:Indoles; C017821:2-amino-3-methyl-9H-pyrido(2,3-b)indole; C023785:2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole; C038742:3-aminonorharman; C023847:Glu-P-2