title: [Restoration of the biological activity of hemagglutinin--neuraminidase in NDV with phospholipids].
abstract: The phospholipids in the membrane of the Newcastle disease virus were hydrolysed by means of the phospholipase enzyme C, whereas the infectious titer of the virus did not change, however its neuraminidase activity dropped. It was found that sphingomyelin in conc. of 250 micrograms/cm3 or lipids of the Newcastle disease virus membrane added to phospholipase C-treated hemagglutinin-neuraminidase restored its activity. The phospholipid 'phosphatidiletanolamine' could not restore the activity of the virus neuraminidase.
mesh_terms: D015707:HN Protein; D006389:Hemagglutinins, Viral / Q000276:immunology*; D006868:Hydrolysis; D009522:Newcastle disease virus / Q000187:drug effects* / Q000201:enzymology / Q000472:pathogenicity; D010743:Phospholipids / Q000378:metabolism / Q000494:pharmacology*; D010738:Type C Phospholipases / Q000494:pharmacology; D014764:Viral Proteins / Q000378:metabolism*; D014774:Virulence / Q000187:drug effects
chemical_list: D015707:HN Protein; D006389:Hemagglutinins, Viral; D010743:Phospholipids; D014764:Viral Proteins; D010738:Type C Phospholipases
vernacular_title: Vŭzstanoviavane na biologichnata aktivnost na khemaglutinin--neuraminidazata na NDV s fosfolipidi.