Effect of chronic treatment of norethisterone (a progestogen-only contraceptive) on preputial gland activity of the female rat.
Long-term treatment of norethisterone (a progestogen-only contraceptive) at a daily dosage of 0.5 mg/rat for consecutive 75 days inhibited the preputial gland activity of the female albino rat. It was evident from the decreased mitotic rate as well as from the decline in the per cent of matured acini. It is suggested that chronic treatment of norethisterone perhaps also involves this gland in contraception in the rat.
D000818:Animals; D002987:Clitoris / Q000033:anatomy & histology / Q000187:drug effects*; D005260:Female; D008938:Mitosis / Q000187:drug effects; D009640:Norethindrone / Q000008:administration & dosage* / Q000494:pharmacology; D045167:Progesterone Congeners / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D045167:Progesterone Congeners; D009640:Norethindrone