Doxorubicin affects actin assembly in vitro.
In vitro experiments on actin polymerization in the presence of doxorubicin show that the rate of salt-induced actin assembly is negatively affected by the drug. The decreased amount of actin monomers keeping their ability to self-interact to give F actin (microfilaments) probably explains the reduction of assembly value. Drug action is dose-dependent and various discrepancies are explained by the limitations of the techniques used.
D000199:Actins / Q000378:metabolism*; D000818:Animals; D002474:Cell-Free System; D003599:Cytoskeleton / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000494:pharmacology*; D005782:Gels; D008854:Microscopy, Electron; D011485:Protein Binding / Q000187:drug effects; D011817:Rabbits
D000199:Actins; D005782:Gels; D004317:Doxorubicin