[Role of serotonin2 receptors in regulating aggressive behavior].
Quipazine and pirenperone , the drugs interacting with serotonin2 -receptors, more readily displaced 3H-spiroperidol from its binding sites in the frontal cortex than in the striatum. Pirenperone (0,07-0,3 mg/kg), antagonist of serotonin2 -receptors, selectively decreased the intensity of apomorphine aggressiveness. The antiaggressive action of haloperidol (0,01-0,2 mg/kg) was in correlation with its antistereotypic activity. Long-term administration of naloxone (0,5; 15,0 mg/kg), together with apomorphine (0,5 mg/kg) reduced the number of head-twitches caused by quipazine (2,5 mg/kg). The administration of quipazine 48 hours after the last injection of naloxone and apomorphine caused spontaneous aggressiveness that did not differ from apomorphine aggressiveness. Intracerebroventricular injection of cholecystokinin tetrapeptide (CCK-4) markedly enhanced the foot-shock aggression. The same dose of CCK-4 also decreased the intensity of quipazine (2,5 mg/kg) head-twitches. Compared to haloperidol, pirenperone was a more selective antagonist of CCK-4. After long-term apomorphine treatment (0,5 mg/kg during 10 days, twice daily), the effect of CCK-4 on aggressive behaviour was markedly enhanced. It is possible that two subtypes of serotonin2 -receptors exist in the brain and have opposite action on the aggressive behaviour. CCK-4 may play the role of an endogenous modulator of sensitivity of serotonin2 -receptors involved in the control of aggressiveness.
D000374:Aggression / Q000502:physiology*; D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors; D001921:Brain / Q000502:physiology*; D003342:Corpus Striatum / Q000378:metabolism; D005625:Frontal Lobe / Q000378:metabolism; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008297:Male; D009270:Naloxone / Q000008:administration & dosage; D010880:Piperidines / Q000494:pharmacology; D011814:Quipazine / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000502:physiology*; D013134:Spiperone / Q000378:metabolism; D013758:Tetragastrin / Q000494:pharmacology
D010880:Piperidines; D011985:Receptors, Serotonin; D013758:Tetragastrin; D009270:Naloxone; D011814:Quipazine; D013134:Spiperone; D006220:Haloperidol; D001058:Apomorphine; C034177:pirenperone
Rol' serotonin2-retseptorov v reguliatsii agressivnogo povedeniia.