Synthesis and biodistribution of radioarsenic labeled dimethylarsinothiols: derivatives of penicillamine and mercaptoethanol.
Arsenic analogs of sulfhydryl containing biomolecules can be derived from dimethylchloroarsine as a precursor. Arsenic-76 labeled dimethylarsinothiols (dimethylarsinopenicillamine and dimethylarsinomercaptoethanol) were synthesized, purified by chromatography, and their biodistributions obtained in mice. The present study demonstrates the possibility of developing a group of radioarsenicals from SH-containing biomolecules.
D000818:Animals; D001151:Arsenic; D001152:Arsenicals / Q000138:chemical synthesis* / Q000378:metabolism; D007553:Isotope Labeling / Q000379:methods; D008297:Male; D051379:Mice; D011868:Radioisotopes; D014018:Tissue Distribution
D001152:Arsenicals; D011868:Radioisotopes; C044974:dimethylarsinopenicillamine; C044975:dimethylarsinomercaptoethanol; D001151:Arsenic