The effect of incorporation of indomethacin with polyethylene glycol 6000 in a solid dispersion on its in vivo properties in the rat.
Preparations of indomethacin and indomethacin in combination with PEG 6000 were administered in solid form by the oral route to male rats. No significant differences in anti-oedema activity were observed between the different preparations of indomethacin, but high blood levels of drug were observed following dosing with indomethacin, in a PEG 6000 melt. Rapid dispersion formulations of indomethacin were also found to be gastro-toxic.
D000818:Animals; D002351:Carrageenan; D004487:Edema / Q000209:etiology / Q000517:prevention & control; D005753:Gastric Mucosa / Q000187:drug effects; D007213:Indomethacin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D013535:Suspensions
D013535:Suspensions; D011092:Polyethylene Glycols; D002351:Carrageenan; D007213:Indomethacin