An electron microscopic study on the type I pneumocyte in the cat: postnatal morphogenesis.
This investigation describes the morphogenesis of the type I pneumocyte from the neonatal stage to the age of 3 months. Cells lining subpleural air spaces were photographed from electron microscopic serial sections and a three-dimensional representation of each cell was obtained by transferring the contours of the cell membranes from micrographs to transparent plastic sheets which were then spaced to scale and stacked. The portion of the reconstructed cell surface taking part in the formation of the blood-air barrier increased extensively in postnatal stages when compared with reconstructed cells of prenatal stages. Reconstructed cell-surface irregularities decrease during distension. A cytoplasmic plate seen in the last stage studied may represent a forming alveolar pore.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000033:anatomy & histology / Q000254:growth & development*; D002415:Cats; D008168:Lung / Q000166:cytology* / Q000254:growth & development / Q000648:ultrastructure; D008854:Microscopy, Electron; D008953:Models, Anatomic