[Distribution and removal of magnetic microcarriers of anti-neoplastic agents from the body].
The dynamics of distribution and removal of different types of magnetic microcarriers have been examined in 450 rats by the method of nuclear absorption spectrophotometry. The concentration of magnetic microcarriers was studied in the brain, heart, lungs, liver, spleen and kidneys in different periods (1 min to 30 days) after single intravenous injection of different types of magnetic fluids. The latter were prepared from the ultrafine powders of magnetite and metallic iron. The magnetic particles had a spherical form and varied from 10 to 70 nm in size. The results of studies have shown that microcarriers made of high-disperse metal iron are most preferable as drug carriers.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D003102:Colloids / Q000008:administration & dosage / Q000378:metabolism*; D052203:Ferrosoferric Oxide; D007501:Iron / Q000378:metabolism; D008280:Magnetics; D008863:Microspheres; D010087:Oxides; D051381:Rats; D013054:Spectrophotometry, Atomic; D014018:Tissue Distribution
D000970:Antineoplastic Agents; D003102:Colloids; D010087:Oxides; D007501:Iron; D052203:Ferrosoferric Oxide
Raspredelenia i vyvedenia iz organizma magnitnykh mikronositeleĭ protivoopukholevykh preparatov.