title: Urinary excretion of digoxin and its metabolites in hyperacidic patients and in patients during coronary care.
abstract: The hydrolytic cleavage of digoxin was studied after single oral doses of tritiated glycoside to four patients with gastric hyperacidity (GH-group) and to six patients during coronary care (CCU-group). Drug analysis was performed with a high-pressure liquid chromatographic method. Results in the two groups did not differ and were similar to results in a previous study in healthy volunteers. On the average 22% of the radioactivity was recovered in 24-h urine specimen. Of this 24.8 +/- 8.5% (GH-group, mean +/- SEM) and 19.3 +/- 6.6% (CCU-group) were cleavage products and unidentified, polar metabolites in equal amounts. This indicates that hydrolysis of digoxin is on average limited even in patients at risk for such metabolic cleavage.
mesh_terms: D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000652:urine*; D004077:Digoxin / Q000652:urine*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D004077:Digoxin