title: Differential responses to osmotic stress of vasopressin-neurophysin mRNA in hypothalamic nuclei.
abstract: mRNA encoding the vasopressin-neurophysin precursor was quantitated in individual hypothalamic nuclei of rats by a liquid hybridization assay. Drinking of 2% saline for 14 days, a treatment that increased the plasma vasopressin concentration 9-fold, resulted in a 5- and 2-fold increase in mRNA levels in the supraoptic and paraventricular nucleus, respectively. This osmotic stimulus had no effect on vasopressin-neurophysin mRNA content of the suprachiasmatic nucleus. This dissociation in regulation of vasopressin-neurophysin mRNA in hypothalamic nuclei indicates the existence of two separate vasopressin systems that are independently activated.
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D009481:Neurophysins / Q000235:genetics*; D009997:Osmotic Pressure; D010286:Paraventricular Hypothalamic Nucleus / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000097:blood / Q000235:genetics*; D013493:Suprachiasmatic Nucleus / Q000378:metabolism; D013495:Supraoptic Nucleus / Q000378:metabolism; D014667:Vasopressins / Q000235:genetics*
chemical_list: D009481:Neurophysins; D012333:RNA, Messenger; D014667:Vasopressins; D001127:Arginine Vasopressin