Constriction of fetal ductus arteriosus by non-steroidal anti-inflammatory drugs:study of additional 34 drugs.
Our study on transplacental effects of 24 non-steroidal anti-inflammatory drugs (NSAID) on the fetal ductus arteriosus of full-term pregnant rats was extended to 34 other NSAID using the same whole-body freezing technique (1). In total, 58 NSAID were evaluated, and their potency in usual clinical doses was classified into 4 grades. Indomethacin and 15 other NSAID caused strong fetal ductal constriction, phenylbutazone and 14 other NSAID caused moderate, and aspirin and 16 other NSAID caused mild constriction of the fetal ductus arteriosus. Salicylamides, and six out of eight basic NSAID did not constrict the fetal ductus arteriosus. Further clinical implications of these results are discussed.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D004373:Ductus Arteriosus / Q000187:drug effects*; D005260:Female; D008431:Maternal-Fetal Exchange; D009200:Myocardial Contraction / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents