title: Calmodulin during development and metamorphosis in urodelan amphibians.
abstract: Calmodulin isolated and purified to homogeneity from young larvae is very similar to that obtained from adult Pleurodeles waltlii and these proteins are almost identical to previously described vertebrate calmodulins. During P. waltlii development, an increase in total individual calmodulin content is observed after the heart beating stage. In dorsal axial muscle, calmodulin level which is very high at the beginning of larval life (premetamorphosis) decreases strikingly in the first part of prometamorphosis. Such an evolution is observed in Ambystoma mexicanum too. Then, a significant increase occurs during metamorphosis. In contrast, calmodulin level in P. waltlii cardiac ventricular muscle increases continuously from hatching to the end of metamorphic climax. Thyroxine treatment which promotes precocious metamorphosis in P. waltlii and experimental metamorphosis in neotenic A. mexicanum, induces a rapid and significant increase in muscle calmodulin concentration.
mesh_terms: D000557:Ambystoma / Q000254:growth & development*; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002147:Calmodulin / Q000502:physiology*; D005260:Female; D007814:Larva; D008675:Metamorphosis, Biological / Q000187:drug effects; D008970:Molecular Weight; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009865:Oocytes / Q000378:metabolism; D010999:Pleurodeles / Q000254:growth & development*; D012455:Salamandridae / Q000254:growth & development*; D013056:Spectrophotometry, Ultraviolet; D013974:Thyroxine / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D002147:Calmodulin; D013974:Thyroxine