Ciprofloxacin concentrations in tonsils following a single intravenous infusion.
Penetration of ciprofloxacin into human tonsils was studied following an intravenous infusion of 200 mg over 15 minutes to adult humans undergoing tonsillectomy. Samples were taken one-and-a-half to four hours after dosing. Generally, tissue levels exceeded corresponding serum concentrations by 50% (range of intraindividual ratios between tonsil and serum concentrations 100% to 288%). Ciprofloxacin distribution was homogeneous and independent of sampling time.
D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood; D002939:Ciprofloxacin; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D014066:Palatine Tonsil / Q000032:analysis*; D011804:Quinolines / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood; D014018:Tissue Distribution; D014068:Tonsillectomy
D000890:Anti-Infective Agents; D011804:Quinolines; D002939:Ciprofloxacin