Suppression of xenogeneic local graft versus host reaction by rat fetal spleen cells.
Xenogeneic local graft versus host reaction was induced by the injection of 5 X 10(7) adult rat spleen cells under the capsule of cyclophosphamide-treated adult mice. A significant decrease in the reaction, measured by the kidney enlargement index, was obtained by adding to the reacting cells 5-20% of fetal rat spleen cells. Fetal rat thymocytes of fetal mouse splenocytes were not found to be inhibitory. The suppressive activity of rat spleen cells waned completely on day 3 of the postnatal life.
D000818:Animals; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D005333:Fetus / Q000276:immunology*; D006087:Graft vs Host Reaction / Q000187:drug effects; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000276:immunology* / Q000637:transplantation; D014183:Transplantation, Heterologous
D003520:Cyclophosphamide