Role of the virulence-associated plasmids of Yersinia enterocolitica on its immunogenicity against Y. pestis.
Forty-two strains selected from various serovars of Yersinia enterocolitica were studied for their ability to induce cross-protection against Y. pestis. Only primo-infected mice (i.v.) with inocula prepared from strains of Y. enterocolitica belonging to serovars 0:3, 0:9 and 0:5, 27 harbouring a 47-Mdal virulence-associated plasmid were resistant to Y. pestis. The spontaneously cured (plasmid-less) derivatives of these strains had lost the capacity to induce this cross-immunity.
D000818:Animals; D003429:Cross Reactions; D004269:DNA, Bacterial / Q000032:analysis; D004587:Electrophoresis, Agar Gel; D005260:Female; D007110:Immunity, Active; D007114:Immunization; D051379:Mice; D010930:Plague / Q000276:immunology*; D010957:Plasmids; D014774:Virulence; D015009:Yersinia Infections / Q000276:immunology*; D015008:Yersinia enterocolitica / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D015010:Yersinia pestis / Q000276:immunology
D004269:DNA, Bacterial