title: Frequency threshold curves and simultaneous masking functions in high-threshold, broadly-tuned, fibres of the guinea pig auditory nerve.
abstract: Tuning curves for simultaneous masking were measured electrophysiologically, in single fibres of the auditory nerve. The recordings were made in guinea pigs with cochlear hearing losses. The masking paradigm was an analogy of that used in the determination of psychophysical tuning curves in man. Below the probe frequency, the slope of the masking function was similar to that of the frequency-threshold curve. Here, changes in the slope of the frequency-threshold curve with hearing loss were closely mirrored by changes in the slope of the masking function. Above the probe frequency, however, the masking function for low-threshold fibres had a shallower slope than the frequency-threshold curve. When the high-frequency slope of the frequency-threshold curve became shallower with hearing loss, the changes were not mirrored in the masking function, until the threshold was raised to 70-80 dB SPL. The results are discussed in terms of the influence of cochlear nonlinearity on frequency resolution, and the vulnerability of the nonlinearity.
mesh_terms: D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects / Q000502:physiology*; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D006168:Guinea Pigs; D008144:Loudness Perception / Q000502:physiology; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology*; D010470:Perceptual Masking / Q000502:physiology*; D010898:Pitch Perception / Q000187:drug effects / Q000502:physiology*; D011571:Psychoacoustics; D014520:Urethane / Q000633:toxicity; D000159:Vestibulocochlear Nerve / Q000187:drug effects / Q000502:physiology*
chemical_list: D014520:Urethane