Effects of naloxone on the cardiovascular responses to muscular contraction in decerebrate cats.
The cardiovascular responses to muscular contraction induced by ventral root (L7 and S1) stimulation were studied in unanesthetized decerebrate cats before and after the administration of the opiate antagonist naloxone. Intravenous naloxone (1.0-2.0 mg/kg) did not alter the heart rate or arterial pressure responses to either tetanic or repeated twitch contractions. However, naloxone did increase resting arterial pressure.
D000818:Animals; D001794:Blood Pressure; D002319:Cardiovascular System / Q000503:physiopathology*; D002415:Cats; D003655:Decerebrate State / Q000503:physiopathology*; D004723:Endorphins / Q000502:physiology*; D006339:Heart Rate; D009119:Muscle Contraction; D009270:Naloxone / Q000494:pharmacology*; D005082:Physical Exertion; D012021:Reflex, Abnormal; D013126:Spinal Nerve Roots / Q000503:physiopathology
D004723:Endorphins; D009270:Naloxone