title: The effects of various doses and various applications of heparin on the fat metabolism and on blood coagulation.
abstract: Various effects of heparin were compared after intravenous infusion and after subcutaneous injection. Administration by the intravenous route causes a considerable amount of heparin to remain in circulation. A strong anticoagulant effect is thereby achieved, but also a diminution of the activity of antithrombin III, a decrease in platelet count and an increase in platelet aggregation. In addition, there is a considerable lipolytic effect. After subcutaneous injection heparin is mainly stored in the RES from where it is gradually released. This causes a much weaker effect on coagulation, on platelets, on antithrombin III and on lipid metabolism. The advantages and disadvantages of both routes of heparin administration are discussed.
mesh_terms: D001777:Blood Coagulation / Q000187:drug effects*; D001792:Blood Platelets / Q000187:drug effects; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D007263:Infusions, Parenteral; D007279:Injections, Subcutaneous; D050356:Lipid Metabolism; D010976:Platelet Count
chemical_list: D006493:Heparin