title: IgG, IgA, IgM and IgE serum levels in asthmatic patients sensitive to house dust and mite allergens after two-year specific immunotherapy.
abstract: The investigations were carried out on 36 atopic asthma patients treated with a specific allergen vaccine--Allpyral. The serum immunoglobulin levels, specific IgE blocking antibodies were determined by various immunological methods. It was shown that a marked rise in the IgG level appeared after 6 months of therapy and maintained during the whole period of observation. This higher IgG level was often correlated with an increase in blocking antibody titer. IgE serum revealed a higher value after 6 months, but on prolongation of the immunotherapy the total IgE level decreased not statistically significantly. The specific IgE antibody showed a tendency to fall after 2-year hyposensitization. The most marked changes in the behaviour of specific IgE and blocking antibodies were observed in the patients with clinical improvement.
mesh_terms: D000328:Adult; D001249:Asthma / Q000276:immunology* / Q000628:therapy; D003888:Desensitization, Immunologic; D004391:Dust / Q000009:adverse effects; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D008925:Mites / Q000276:immunology; D013997:Time Factors
chemical_list: D004391:Dust; D007136:Immunoglobulins; D007073:Immunoglobulin E