Metabolism of hydralazine by rat hepatocytes.
The metabolism of hydralazine and its pyruvic acid hydrazone was studied in a medium containing isolated adult rat hepatocytes. Hydralazine undergoes conversion to 3-methyltriazolophthalazine, while hydralazine pyruvic acid hydrazone is not metabolized in rat hepatocytes.
D000818:Animals; D002478:Cells, Cultured; D002855:Chromatography, Thin Layer; D005260:Female; D006830:Hydralazine / Q000031:analogs & derivatives / Q000378:metabolism*; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D010793:Phthalazines / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D010793:Phthalazines; C008508:3-methyl-s-triazolo(3,4-a)phthalazine; D006830:Hydralazine; C023497:hydralazine pyruvic acid hydrazone