Chemotherapy-induced fatal pulmonary fibrosis.
The case of a girl with relapsing ependymoma is described, who received BCNU and vincristine treatment. She developed progressive, pulmonary fibrosis as a consequence of chemotherapy, which lead to her death. Predisposing factors, clinical and histological findings are discussed and suggestions are made for the regular and preventive checking of the patients' pulmonary function.
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001932:Brain Neoplasms / Q000532:radiotherapy / Q000601:surgery; D002330:Carmustine / Q000009:adverse effects; D002675:Child, Preschool; D004806:Ependymoma / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000601:surgery; D011030:Pneumothorax / Q000000981:diagnostic imaging; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000401:mortality; D011859:Radiography; D012306:Risk; D013997:Time Factors; D014750:Vincristine / Q000009:adverse effects
D014750:Vincristine; D002330:Carmustine