Large bowel stenosis in rats after fractionated local irradiation.
After local irradiation of the distal large bowel rats may develop fatal large bowel stenosis within 200 days. The incidence rises steeply with dose. The LD50 for single dose irradiation is 20 Gy. The tolerance of the large bowel to local irradiation depends strongly on dose fractionation. Extending the intervals between the fractions and decreasing the dose per fraction both have a pronounced dose-sparing effect.
D000818:Animals; D003106:Colon / Q000528:radiation effects; D003108:Colonic Diseases / Q000209:etiology*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D007415:Intestinal Obstruction / Q000209:etiology*; D011833:Radiation Injuries, Experimental; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors