Superoxide dismutase, catalase and lipid peroxidation in liver of young mice of different ages.
The lipid peroxidation and activities of main enzymes involved in the peroxide metabolism were measured at resting conditions and after completion of a 2-month treatment with H2O2. At the start of the experiments 1- and 3-month-old female BALB/c mice received either a high dose of H2O2 (0.5% H2O2 in drinking water; intake 12.5 x 10(-3) g/day/mouse) or a low dose of H2O2 (0.5 ml of 0.5% H2O2 by esophageal canula on every alternate day; intake 1.0 x 10(-3) g/day/mouse). The following conclusions can be drawn: a relative higher increase in activity of catalase could be induced at the age of 3 months than at the age of 5 months by a high dose of H2O2. The activity of superoxide dismutase (SOD) was not changed by a high dose of H2O2. A moderate increase in the activity of catalase and a remarkable decrease in SOD-activity resulted from a low-dose H2O2 treatment at the age of 5 months. The level of lipid peroxidation was increased by the low-dose and not influenced by the high-dose H2O2 treatment in 5-month-old-mice.
D000375:Aging; D000818:Animals; D002374:Catalase / Q000378:metabolism; D005260:Female; D006861:Hydrogen Peroxide / Q000494:pharmacology; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D051379:Mice; D008807:Mice, Inbred BALB C; D013482:Superoxide Dismutase / Q000378:metabolism
D008054:Lipid Peroxides; D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase