title: [In vitro sensitivity of epidermoid lung cancer to cytostatics depending upon the degree of tumor differentiation].
abstract: In vitro sensitivity of epidermoid lung carcinoma to chemotherapeutic agents in short-term cultures versus degree of tumor differentiation was evaluated for the following drugs: 5-fluorouracil, methotrexate, olivomycin, bleomycin, carminomycin, adriablastin, prospidium chloride, vincristine, thiophosphamide, novembichine and photrine. The results of the investigation using resected material from 77 cases of histologically confirmed epidermoid lung carcinoma failed to establish any relationship between the parameters under study for all above drugs except vincristine. However, tumors showing similar levels of differentiation demonstrated different sensitivity to certain drugs.
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000473:pathology*; D002470:Cell Survival / Q000187:drug effects; D004351:Drug Resistance; D006801:Humans; D066298:In Vitro Techniques; D008175:Lung Neoplasms / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents
vernacular_title: Chuvstvitel'nost' épidermoidnogo raka legkikh in vitro k tsitostatikam v zavisimosti ot stepeni differentsiatsii opukholi.