The effect of endotoxin and radio-detoxified endotoxin on the serum T4 level of rats and response of their thyroid gland to exogenous TSH.
We have demonstrated that, while the shock-inducing dose of parent (toxic) endotoxin significantly decreases the serum T4 level of rats and inhibits the T4 response given to exogenous thyroid stimulating hormone (TSH), the radio-detoxified (60Co-gamma, 150 kGy) endotoxin preparation does not inhibit the response to exogenous TSH and decreases serum T4 level to a lesser extent than untreated endotoxin.
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects; D004731:Endotoxins / Q000494:pharmacology* / Q000528:radiation effects; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000187:drug effects*; D013972:Thyrotropin / Q000494:pharmacology*; D013974:Thyroxine / Q000097:blood*
D004731:Endotoxins; D013972:Thyrotropin; D013974:Thyroxine