Induction of single-strand breaks in DNA of mice after inhalation of vinyl chloride.
Female mice were exposed to 500 ppm vinyl chloride (VC) for 6 h/day 5 days/week for 1-8 weeks. Groups of mice were killed at different times during this period. DNA damage, expressed as single-strand breaks (SSB), was studied in liver, kidneys, lungs, spleen and brain. The level of SSB increased in liver, kidneys, spleen and lungs with time of exposure and reached a plateau for kidneys and lungs after 80 and 120 h of exposure. In spleen there was only a slight increase in the SSB, and in brain no detectable increase was found.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D004277:DNA, Single-Stranded / Q000378:metabolism*; D004781:Environmental Exposure; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors; D014752:Vinyl Chloride / Q000494:pharmacology*; D014753:Vinyl Compounds / Q000494:pharmacology*
D004277:DNA, Single-Stranded; D014753:Vinyl Compounds; D014752:Vinyl Chloride