Acute 60Co-gamma irradiation of rats decreases the inhibitory effect of succinate on the lipid peroxidation of liver mitochondria.
Succinate inhibits NADPH-dependent lipid peroxidation of liver mitochondria. This effect of succinate decreased 12 h after whole-body 60Co-gamma irradiation, depending on the dose of irradiation.
D000818:Animals; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D051381:Rats; D013386:Succinates / Q000494:pharmacology*; D019802:Succinic Acid
D003037:Cobalt Radioisotopes; D008054:Lipid Peroxides; D013386:Succinates; D019802:Succinic Acid