title: Evidence of a thromboxane A2-Ca2+ complex: a conformational approach.
abstract: Thromboxane A2 has been proposed as an ionophore capable to transport calcium from the platelet dense tubular system to the cytoplasm to activate the contractile proteins. However the half-life (30 sec.) of this compound limits considerably the experimental approach. The conformational analysis is proposed here as a possible way to identify such transient conformations. We bring evidence of the existence of two Ca2+-thromboxane A2 isomeric complexes: one structure responsible for the complexation-decomplexation process at the interface and one lipophilic structure able to cross the lipid membrane.
mesh_terms: D002118:Calcium / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D008968:Molecular Conformation; D013237:Stereoisomerism; D013928:Thromboxane A2 / Q000378:metabolism*; D013931:Thromboxanes / Q000378:metabolism*; D014961:X-Ray Diffraction
chemical_list: D013931:Thromboxanes; D013928:Thromboxane A2; D002118:Calcium