Splenic macrophages during pregnancy in the mouse.
Pregnant CBA/Ca mice at mid-gestation showed a two-fold increase in the relative content of splenic macrophages, a change which was suggested to be due to enhanced migration. The proportion of spleen cells carrying a high density of Fc-receptors (assayed by EA-rosetting) was similarly increased in pregnant mice. The splenic content of non-lymphoid strongly esterase-positive cells was dramatically elevated at mid-gestation, but this increase was shown basically to be due to elevated numbers of esterase-staining erythroid blast cells. The pattern of the increase of Ig-secreting spleen cells was compared with that of macrophages and erythroid blast cells, and possible unspecific interaction at tissue-level is discussed.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D002448:Cell Adhesion; D002452:Cell Count; D002470:Cell Survival; D004950:Esterases / Q000032:analysis; D005260:Female; D006412:Hematopoietic Stem Cells / Q000032:analysis; D008264:Macrophages / Q000201:enzymology / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D011270:Pregnancy, Animal; D011961:Receptors, Fc / Q000032:analysis; D012397:Rosette Formation; D013154:Spleen / Q000166:cytology / Q000276:immunology*
D011961:Receptors, Fc; D004950:Esterases