[Plasma concentrations of phenobarbital and dosage according to age].
Phenobarbital was used as first treatment in 198 subjects with different loading doses adjusted according to age, followed by a daily maintenance dose of 5 mg/kg. A loading dose was given per os to 136 infants in four groups and intravenously to 62 subjects in five groups (including 30 adults). We found that the intravenous route must be used for the rapid production of therapeutic plasma concentrations and accordingly we recommend it in intensive care. Posology of 20 mg/kg i.v. appears to be adequate in children up to 15 years old while a posology of 15 mg/kg seems to be too high in adults. The maximum probability of efficiency is delayed up to 12 h when phenobarbital is given per os. Various posologies were found to be adequate in infants except for premature newborns.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007275:Injections, Intravenous; D010634:Phenobarbital / Q000008:administration & dosage / Q000097:blood*; D013997:Time Factors
D010634:Phenobarbital
Concentrations plasmatiques de phénobarbital et posologie en fonction de l'âge.