[Differences in the action of typical and atypical tranquilizers on the structure and function of mitochondria during emotional-painful stress].
Experiments were made to study the effect of a typical (chlorodiasepoxide) and an atypical (lithonite) tranquilizers on the structure and function of mitochondria in emotional-painful stress. It was demonstrated that emotional-painful stress gives rise to the disturbance of the activity of mitochondrial enzymes responsible for tissue respiration and oxidative phosphorylation. This is accompanied by an increase in the relative volume of the mitochondria, their swelling, diminution in the number of crysts and by their fragmentation. As shown by the data of fluorescent studies, the intermolecular relations of the mitochondrial membranes get disturbed, which is likely to be a reason for a change in the activity of mitochondrial enzymes. Lithonite made the activity of the enzymes and the structure of the mitochondria return to normal and stabilized membrane permeability. Chlorodiasepoxide did not exert any such action on the majority of indicators under study.
D000818:Animals; D001921:Brain / Q000201:enzymology; D002707:Chlordiazepoxide / Q000627:therapeutic use; D004734:Energy Metabolism; D006801:Humans; D008297:Male; D008928:Mitochondria / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D009539:Nicotinic Acids / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013003:Somatosensory Cortex / Q000648:ultrastructure; D013315:Stress, Psychological / Q000188:drug therapy*; D014149:Tranquilizing Agents / Q000627:therapeutic use*
D009539:Nicotinic Acids; D014149:Tranquilizing Agents; D002707:Chlordiazepoxide; C041554:litonit
O razlichiiakh v deĭstvii tipichnykh i atipichnykh trankvilizatorov na strukturu i funktsiiu mitokhondriĭ pri émotsional'no-bolevom stresse.