title: Third order linkage disequilibrium.
abstract: For third order linkage disequilibrium there is a constraint on the maximum value the disequilibrium can take, given pairwise disequilibria values and allele frequencies. As distinct from second order disequilibrium (considered in the context of a two locus model) there is also in some cases a constraint on the minimum value. The appropriate procedures to determine these maximum and minimum values are given, as well as numerical values utilizing HLA data.
mesh_terms: D000483:Alleles; D005787:Gene Frequency; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008957:Models, Genetic; D013223:Statistics as Topic
chemical_list: D006680:HLA Antigens