Stimulation of DNA synthesis after a single administration of cadmium nitrate.
The effect of a single intravenous (i.v.) injection of cadmium nitrate was investigated in livers of male Wistar rats. A significant increase in liver weight, accompanied by an elevation of total hepatic DNA content was observed. DNA synthesis as measured by the incorporation of [3H]thymidine, was found to be 6 times greater than the control, at 24 h after treatment, and remained elevated over a period of 72 h. This elevation in DNA synthesis was not a consequence of cell necrosis, since no increase of serum glutamate-pyruvate transaminase (SGPT) activity was observed.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001345:Autoradiography; D002104:Cadmium / Q000494:pharmacology*; D019187:Cadmium Compounds; D004247:DNA / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009566:Nitrates; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013936:Thymidine / Q000378:metabolism
D019187:Cadmium Compounds; D009566:Nitrates; D002104:Cadmium; D004247:DNA; D000410:Alanine Transaminase; D013936:Thymidine; C035196:cadmium nitrate