In vitro synergism of nalidixic acid with other broad spectrum antibiotics.
In vitro studies of the activity of antibiotic combinations in the ratio 1:1: nalidixic acid plus cephaloridine, nalidixic acid plus kanamycin and nalidixic acid plus erythromycin were performed by using an agar dilution technique with Mueller-Hinton Agar. Of 156 Enterobacteriaceae tested, nalidixic acid plus cephaloridine were synergistic for 96 (61.5%) strains compared with 101 (64.7%) with nalidixic acid plus kanamycin (P less than 0.01) and 85 (54.5%) with nalidixic acid plus erythromycin (P less than 0.001). These data suggest these combinations as possible effective tools in clinical trials, especially directed toward high level resistant urinary tract pathogens.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004338:Drug Combinations; D004357:Drug Synergism; D008826:Microbial Sensitivity Tests; D009268:Nalidixic Acid / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D009268:Nalidixic Acid