[Interrelation of diabetes mellitus, atherosclerosis and ischemic heart disease].
In patients with diabetes mellitus, the processes of lipid peroxidation are activated and the system of antioxidants is disturbed (the content of reduced glutathione and red cell glutathione reductase is lowered and red cell glutathione peroxidase activity is heightened). At the same time the patients demonstrate high concentration of sterols bound by fibrinogen, a considerable lowering of cholesterol content in high density lipoproteins having an antiiatrogenic action. The alterations found underlie the development of atherosclerosis and coronary heart disease.
D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000097:blood* / Q000209:etiology; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000097:blood* / Q000209:etiology; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005340:Fibrinogen / Q000097:blood; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D013261:Sterols / Q000097:blood
D008054:Lipid Peroxides; D008075:Lipoproteins, HDL; D013261:Sterols; D005340:Fibrinogen; D002784:Cholesterol; D005979:Glutathione Peroxidase; D005980:Glutathione Reductase; D005978:Glutathione
Issledovanie vzaimosviazi sakharnogo diabeta, ateroskleroza, ishemicheskoĭ bolezni serdtsa.