Antihepatotoxic actions of papyriogenins and papyriosides, triterpenoids of Tetrapanax papyriferum leaves.
Antihepatotoxic actions of the papyriogenins and papyriosides from Tetrapanax papyriferum leaves were examined utilizing carbon tetrachloride (CCl4)- and galactosamine (GalN)-induced cytotoxicity in primary cultured rat hepatocytes. Remarkable antihepatotoxic effects were observed with papyriogenin B, papyriogenin A, propapyriogenin A2, papyriogenin C, 11-dehydropropapyriogenin A2, 16-epi-saikogenin C and propapyriogenin A1 in the CCl4-induced cytotoxicity assay, and papyriogenin A, propapyriogenin A1 and propapyriogenin A2 were active in preventing GalN-induced cytotoxicity although these triterpenoids were rather cytotoxic at a higher dose in the latter assay. Structure-activity relationship is discussed.
D000410:Alanine Transaminase / Q000378:metabolism; D000818:Animals; D002251:Carbon Tetrachloride / Q000037:antagonists & inhibitors; D002478:Cells, Cultured; D005688:Galactosamine / Q000037:antagonists & inhibitors; D008099:Liver / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D009828:Oleanolic Acid / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D012502:Sapogenins / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000302:isolation & purification / Q000494:pharmacology*
D012502:Sapogenins; D014315:Triterpenes; D009828:Oleanolic Acid; D005688:Galactosamine; D002251:Carbon Tetrachloride; D000410:Alanine Transaminase