title: Effect of aging on liver glutathione levels and hepatocellular injury from carbon tetrachloride, allyl alcohol or galactosamine.
abstract: Severity of liver damage 24 hr after i.p. administration of carbon tetrachloride (0.2 ml/kg), allyl alcohol (0.036 ml/kg) or galactosamine (400 mg/kg) was evaluated in male rats at 4-5, 14-15 or 24-25 months of age. Allyl alcohol hepatotoxicity, as judged by light microscopy and serum alanine aminotransferase levels, increased markedly as a function of age. In contrast, carbon tetrachloride and galactosamine toxicities were unchanged or slightly diminished in old rats. Hepatic glutathione (GSH) concentrations were unaffected by aging; thus, the age-dependent increase in susceptibility to allyl alcohol toxicity was not a result of diminished GSH availability in old age. Hepatotoxicant-induced changes in GSH were observed in allyl alcohol-treated old rats (20% increase) and in galactosamine-treated young-adult and middle-aged rats (30% decrease).
mesh_terms: D000433:1-Propanol / Q000633:toxicity; D000375:Aging; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000378:metabolism*; D005688:Galactosamine / Q000633:toxicity*; D005978:Glutathione / Q000378:metabolism*; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008297:Male; D020005:Propanols; D051381:Rats; D011916:Rats, Inbred F344; D013438:Sulfhydryl Compounds / Q000378:metabolism
chemical_list: D020005:Propanols; D013438:Sulfhydryl Compounds; C006463:allyl alcohol; D005688:Galactosamine; D000433:1-Propanol; D000410:Alanine Transaminase; D005978:Glutathione