Absence of histopathology in somatic tissues of rats made infertile with gossypol.
Although the effect of gossypol on the testis and epididymis has been well documented, its effect on the somatic tissues of animals made infertile with the drug has been less well studied. In this study rats were treated daily with gossypol at either 20 mg/kg or 30 mg/kg for 6 weeks and at 10 mg/kg for 7 months. Complete tissue sets from control and gossypol-treated rats, including 26 organs, were subjected to histological examination. No significant histopathological differences were noted at the light microscope level between the control and infertile groups.
D000302:Adrenal Cortex / Q000473:pathology; D000818:Animals; D002531:Cerebellum / Q000473:pathology; D003272:Contraceptive Agents, Male / Q000633:toxicity*; D006072:Gossypol / Q000633:toxicity*; D007672:Kidney Cortex / Q000473:pathology; D007765:Lacrimal Apparatus / Q000473:pathology; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D010179:Pancreas / Q000473:pathology; D010280:Parathyroid Glands / Q000473:pathology; D051381:Rats; D013950:Thymus Gland / Q000473:pathology
D003272:Contraceptive Agents, Male; D006072:Gossypol