[Mechanism of the anabolic action of phytoecdisteroids in mammals].
In experiments with white mice it has been established that phytoecdisteroides turkesteron, ecdisteron and 2-desoxy-alpha-ecdison in the dose of 5 mg on 1 kg of body mass stimulate the protein synthesis. Using the model of protein synthesis from mice liver it has been shown that the action of phytoecdisteroides is connected with the rise of poliribosome functional activity and rate increase of protein macromolecules formation. Preliminary administration of actinomycin D does not prevent the effect of protein synthesis stimulation. It has been concluded that the anabolic effect of phytoecdisteroides in mammals organism is connected not with induction of RNA synthesis but with the acceleration of translocation processes.
D000818:Animals; D002783:Cholestenones / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D004440:Ecdysone / Q000031:analogs & derivatives / Q000494:pharmacology; D004441:Ecdysterone / Q000494:pharmacology / Q000031:analogs & derivatives; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008660:Metabolism / Q000187:drug effects*; D051379:Mice; D010840:Phytosterols / Q000494:pharmacology*; D011132:Polyribosomes / Q000187:drug effects / Q000378:metabolism; D014176:Protein Biosynthesis
D002783:Cholestenones; D010840:Phytosterols; D003609:Dactinomycin; C044348:2-deoxyecdysone; D004440:Ecdysone; D004441:Ecdysterone; C017787:turkesterone
K mekhanizmu anabolicheskogo deĭstviia fitoékdisteroidov v organizme mlekopitaiushchikh.