Light and electron microscopic studies of an antibiotic bonded vascular graft.
Polytetrafluoroethylene grafts were bonded to oxacillin with the cationic surfactant, benzalkonium chloride. Grafts were placed in the canine aorta and harvested six and twelve weeks after implantation. Light and scanning and transmission electron microscopy were performed in all specimens. No histological differences could be demonstrated between control and antibiotic bonded grafts. Significant antibacterial activity was demonstrated at the time of graft implantation. However, none remained six and twelve weeks later.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001011:Aorta / Q000601:surgery; D001548:Benzalkonium Compounds; D001807:Blood Vessel Prosthesis; D004285:Dogs; D008853:Microscopy; D008854:Microscopy, Electron; D010068:Oxacillin / Q000627:therapeutic use; D011138:Polytetrafluoroethylene; D011474:Prosthesis Design; D013203:Staphylococcal Infections / Q000517:prevention & control; D013501:Surface-Active Agents; D013530:Surgical Wound Infection / Q000517:prevention & control*
D000900:Anti-Bacterial Agents; D001548:Benzalkonium Compounds; D013501:Surface-Active Agents; D011138:Polytetrafluoroethylene; D010068:Oxacillin