Synthesis of hypolipidemic silybin analog 3',4'-ethylenedioxyflavonoids.
For pharmacological investigation various types of silybin analogues have been synthesized. According to the results of preliminary tests, many of the prepared benzodioxane analogues of chalcones, chalcone epoxides, isoflavones, flavanones and aurones possessed hypolipidemic activity.
D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D005419:Flavonoids / Q000138:chemical synthesis*; D000960:Hypolipidemic Agents / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D012838:Silymarin / Q000031:analogs & derivatives / Q000138:chemical synthesis*
D005419:Flavonoids; D000960:Hypolipidemic Agents; D012838:Silymarin