title: Neural-tube defects produced in Syrian hamsters by potato glycoalkaloids.
abstract: Keeler et al. (78) showed that potato sprouts could be teratogens for the central nervous system in the Syrian hamster. We demonstrate here the same teratogenic effect from a British cultivar, Arran Pilot. Most of the activity was traced to the two solanidine triglycosides, alpha-chaconine and, at a higher dose level, alpha-solanine. Some possible implications for the study of human neural-tube defects are considered.
mesh_terms: D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008647:Mesocricetus; D009436:Neural Tube Defects / Q000139:chemically induced*; D011247:Pregnancy; D012737:Sex Factors; D012992:Solanine / Q000031:analogs & derivatives* / Q000633:toxicity*; D014675:Vegetables / Q000032:analysis
chemical_list: D012992:Solanine; C011860:alpha-chaconine