title: Effects of antihypertensive drugs on cognitive function in adolescents.
abstract: The effects of clonidine and hydrochlorothiazide on cognitive function were studied in hypertensive adolescents requiring pharmacologic therapy for blood pressure control. Twenty-four adolescents with persistent blood pressure elevation (greater than 95th%) on placebo were randomized double blind to clonidine or hydrochlorothiazide treatment. A battery of cognitive tests were performed during the placebo phase and after 16 weeks of active therapy. Antihypertensive therapy resulted in significant blood pressure reduction (p less than .01). A slight interactive effect was observed in arithmetic performance (p less than .05). All other parameters of cognitive function were not affected by either treatment.
mesh_terms: D000293:Adolescent; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D003000:Clonidine / Q000009:adverse effects; D003071:Cognition / Q000187:drug effects*; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects; D006973:Hypertension / Q000188:drug therapy / Q000523:psychology; D008297:Male
chemical_list: D000959:Antihypertensive Agents; D006852:Hydrochlorothiazide; D003000:Clonidine