Idiotypic interrelationship among human myeloma proteins with distinct antibody-binding specificities.
There have been several reports of human myeloma proteins exhibiting autoantibody activity. Such immunoglobulins represent therefore an appropriate system for investigating idiotypic diversity of human autoantibodies. Using this approach, we confirmed the marked idiotypic restriction of polyclonal anti-DNA autoantibodies and we showed that immunoglobulins without known binding affinity may express autoantibody-related idiotopes. These results are discussed in lights of recent concepts upon autoimmune processes and idiotypic interactions.
D000918:Antibody Specificity; D001323:Autoantibodies / Q000276:immunology*; D004247:DNA / Q000276:immunology*; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D009194:Myeloma Proteins / Q000276:immunology*
D001323:Autoantibodies; D007130:Immunoglobulin Idiotypes; D009194:Myeloma Proteins; D004247:DNA