The effect of delta-aminolaevulinic acid on the high affinity uptake of aspartic acid by rat brain synaptosomes.
delta-Aminolaevulinic (delta-ALA) acid is an analogue of GABA, glutamate and aspartate. High affinity GABA uptake by synaptosomes is inhibited by delta-ALA in a competitive fashion at high concentrations (greater than 0.5 mM). Glutamate uptake is inhibited in a non-competitive fashion at all delta-ALA concentrations (0.05-2.0 mM). High affinity aspartate uptake is inhibited in a non-competitive fashion at high concentration (greater than 1.0 mM) but exhibits a curve which resembles that for the inhibition of GABA uptake. The different interactions between delta-ALA, glutamate and aspartate may be evidence for a separate transport system for aspartate.
D000622:Aminolevulinic Acid / Q000494:pharmacology*; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism; D066298:In Vitro Techniques; D007982:Levulinic Acids / Q000494:pharmacology*; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D005971:Glutamates; D007982:Levulinic Acids; D001224:Aspartic Acid; D005680:gamma-Aminobutyric Acid; D000622:Aminolevulinic Acid