title: [In vitro studies on the effect of dissolved and undissolved heterologous collagen sponge on human thrombocytes].
abstract: Hemostasis in bone-bleeding is difficult. Local haemostatics are often used. We take xenolog collagen-sponge--in bone defects--combined with synthetic apatite, to achieve additional osteoinduction. Mechanism of haemostasis by collagen-sponge is examined. After a detailed discussion of literature in vitro experiments with xenolog collagen-sponge and dissolved collagen-sponge (Pentapharm Braun Melsungen) are reported. While native collagen is an important natural haemostatic agent, this collagen-specific effect is not observed in our experiments, neither in platelets nor in endoplasmatic haemostasis. Regarding clinical eperiences physical effects must be considered as mechanism of haemostasis by xenolog collagen-sponge.
mesh_terms: D001792:Blood Platelets / Q000187:drug effects*; D003094:Collagen / Q000494:pharmacology*; D006490:Hemostatics / Q000494:pharmacology*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*
chemical_list: D006490:Hemostatics; D003094:Collagen
vernacular_title: In vitro-Untersuchungen über die Wirkung von gelöstem und ungelöstem heterologen Collagen-Vlies auf menschliche Thrombozyten.