title: [Characteristics of hepatocyte proliferation in the regenerating rat liver with hydroxyurea synchronization of the proliferative processes].
abstract: 5-week old rats underwent a partial hepatectomy (2/3 of the liver was removed). The operated rats were repeatedly injected hydroxyurea, within 9-24 or 12-24 hours following operation. Proliferation of hepatocytes and non-parenchymal cells in the regenerating liver was studied. Five or six injections of hydroxyurea increased the labelling index of hepatocytes up to 62.5% and induced proliferation of bile duct cells significantly.
mesh_terms: D000818:Animals; D001345:Autoradiography; D002455:Cell Division / Q000187:drug effects; D006498:Hepatectomy; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology*; D008099:Liver / Q000166:cytology / Q000187:drug effects*; D008115:Liver Regeneration / Q000187:drug effects*; D008940:Mitotic Index / Q000187:drug effects; D051381:Rats; D013997:Time Factors
chemical_list: D006918:Hydroxyurea
vernacular_title: Osobennosti proliferatsii gepatotsitov regeneriruiushcheĭ pecheni krys pri sinkhronizatsii proliferativnykh protsessov oksimochevinoĭ.