title: The uptake of lead by small intestine, colon and gallbladder of the guinea pig in vivo.
abstract: The binding and uptake of lead by the jejunal, colonic and gallbladder epithelium of guinea pig has been investigated by electron microscopy. Binding occurred rapidly, the most marked by the microvilli was by the jejunum, followed by colon and gallbladder. The tracer was subsequently internalised in small membrane bound vesicles and smooth endoplasmic reticulum. By 30 min, it appeared in multivesicular bodies at all three sites.
mesh_terms: D000818:Animals; D003106:Colon / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism / Q000648:ultrastructure; D005704:Gallbladder / Q000378:metabolism* / Q000648:ultrastructure; D006168:Guinea Pigs; D007421:Intestine, Small / Q000378:metabolism* / Q000648:ultrastructure; D007700:Kinetics; D007854:Lead / Q000378:metabolism*; D008854:Microscopy, Electron; D008871:Microvilli / Q000378:metabolism* / Q000648:ultrastructure; D009928:Organ Specificity
chemical_list: D007854:Lead