title: Change-over clinical trial with binary data: mixed-model-based comparison of tests.
abstract: A mixed model is proposed for the two-period change-over clinical trial with binary responses. Tests for the treatment effect are derived under several versions of this model. This approach reveals the relative merits of tests previously described in the literature and leads to a new test for the carry-over effect.
mesh_terms: D001699:Biometry / Q000379:methods*; D002986:Clinical Trials as Topic / Q000379:methods*; D006801:Humans