[Molecular mechanisms of interphase death of lymphoid cells. Distribution of transcribable sequences in products of the postradiation degradation of rat thymus chromatin].
The method of hybridization was used to study the presence of the transcribed sequences in PDN subfractions. As a component of mononucleosomes possessing a high electrophoretic motility DNA was enriched with the diverse unique transcribed siquences. It was shown that during the postirradiation degradation of the chromatin the mononucleosome fragments of PDN were mainly formed from the genome sites active in transcription whereas the high molecular weight fragments contained its repressed sequences.
D000818:Animals; D001483:Base Sequence; D002843:Chromatin / Q000528:radiation effects*; D008297:Male; D009693:Nucleic Acid Hybridization; D011089:Polydeoxyribonucleotides / Q000032:analysis; D011831:Radiation Genetics; D051381:Rats; D013950:Thymus Gland / Q000166:cytology / Q000528:radiation effects; D014158:Transcription, Genetic / Q000528:radiation effects*
D002843:Chromatin; D011089:Polydeoxyribonucleotides
Molekuliarnye mekhanizmy interfaznoĭ gibeli limfoidnykh kletok. Raspredelenie transkribiruemykh posledovatel'nosteĭ v produktakh posttradiatsionnoĭ degradatsii khromatina timusa krys.