title: Effects of essential fatty acids on prostaglandin biosynthesis.
abstract: Prostaglandins (PGs) are derived from dietary essential fatty acids (EFAs) by relatively short biochemical pathways. PG synthesis can be manipulated by modifying EFA intake. PGs and related compounds of the 1 and 3 series have desirable or neutral actions while those of the 2 series are mixed, some being desirable but others being highly undesirable. Methods for selectively increasing 1 and 3 series products while simultaneously reducing the formation of arachidonic acid derivatives are described.
mesh_terms: D000818:Animals; D006224:Cricetinae; D004041:Dietary Fats; D004285:Dogs; D005228:Fatty Acids, Essential / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000096:biosynthesis; D006168:Guinea Pigs; D006801:Humans; D051379:Mice; D011453:Prostaglandins / Q000096:biosynthesis*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013329:Structure-Activity Relationship
chemical_list: D004041:Dietary Fats; D005228:Fatty Acids, Essential; D005231:Fatty Acids, Unsaturated; D011453:Prostaglandins