Synthesis and pharmacological evaluation of imidazopyridinium derivatives as neuromuscular blocking agents.
A series of new imidazo[1,2-a]pyridinium derivatives have been prepared and studied as neuromuscular blocking agents in rats. These new substances are structurally related to fazadinium whose heterocyclic moieties were retained. All the new synthetized compounds are endowed with competitive neuromuscular blocking activity both in vitro and in vivo. Some were found to be equieffective with fazadinium with similar cardiovascular effects while some others possess more favorable therapeutic indexes.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002645:Chickens; D006439:Hemodynamics / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D009466:Neuromuscular Blocking Agents / Q000138:chemical synthesis*; D010243:Paralysis / Q000139:chemically induced; D010791:Phrenic Nerve / Q000187:drug effects; D011726:Pyridinium Compounds / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D007093:Imidazoles; D009466:Neuromuscular Blocking Agents; D011726:Pyridinium Compounds