Effects of a placental hormone, human chorionic somatomammotropin on normal and malignant cells.
Studies were made on the effects of human chorionic somatomammotropin (HCS) on normal and malignant cells and tissues in Swiss mice. HCS was found to produce a significant increase in the fresh weight of normal liver, kidney, spleen, testis, ovary and uterus. Total cell counts of leukocytes and erythrocytes were elevated. The percentage of granulocytes in blood was found to be increased and the percentage of lymphocytes was decreased following HCS treatment. HCS stimulated the growth of ascitic Ehrlich's carcinoma and Sarcoma 180, and nucleic acid synthesis by these tumor cells. A depression in the mitogen induced blastogenesis of lymphocytes was also noted following HCS treatment.
D000818:Animals; D001773:Blood Cells / Q000187:drug effects; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology*; D002452:Cell Count; D002455:Cell Division / Q000187:drug effects; D002477:Cells / Q000187:drug effects*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D009368:Neoplasm Transplantation; D010928:Placental Lactogen / Q000494:pharmacology*; D012509:Sarcoma / Q000473:pathology*
D010928:Placental Lactogen