Repeated treatment with antidepressant drugs prevents salbutamol-induced hypoactivity in rats.
We have found earlier that a number of antidepressant drugs, administered repeatedly, prevent the salbutamol-induced hypoactivity in rats. Our further experiments show that a similar effect is produced by repeated, but not acute, treatment with other antidepressants: clomipramine, mianserin and nialamide. Two non-antidepressant psychotropic drugs, haloperidol and diazepam, were inactive after repeated administration. These results seem to support our earlier hypothesis that prevention of the salbutamol-induced hypoactivity may be regarded as functional evidence at the behavioral level for the subsitivity of beta-adrenoceptors.
D000420:Albuterol / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002997:Clomipramine / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D008803:Mianserin / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects*; D009526:Nialamide / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000928:Antidepressive Agents; D008803:Mianserin; D006220:Haloperidol; D002997:Clomipramine; D003975:Diazepam; D000420:Albuterol; D009526:Nialamide