title: Fetal lamb clearance of morphine as determined by high performance liquid chromatography with electrochemical detection.
abstract: Morphine clearance from plasma was determined during constant rate drug infusion in 10 late gestation fetal lambs. Clearance, 65 +/- 6 ml.min-1.kg-1, was independent of infusion rate. Morphine clearance was a first order process in the dose range studied.
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D009020:Morphine / Q000097:blood*; D011247:Pregnancy; D012756:Sheep
chemical_list: D009020:Morphine