title: Depressed mononuclear cell phagocytic activity associated with menstruation.
abstract: The peak of the normal distribution curve for pelvic inflammatory disease occurs near the onset of menses. This study was undertaken to determine if there were changes in the cell-mediated immunity of normal menstruating women which could explain the increase in inflammatory disease. The cellular immune response of 8 normal women, measured by number of T- and B-cells and response of mononuclear cells to stimulation with mitogen, was not dependent on the menstrual cycle. However, there was a significant decrease in phagocytic activity of mononuclear cells early in the cycle. The depressed phagocytic activity was not altered by treating the subjects with ibuprofen.
mesh_terms: D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008597:Menstrual Cycle; D008598:Menstruation; D008934:Mitogens / Q000494:pharmacology; D000292:Pelvic Inflammatory Disease / Q000209:etiology; D010586:Phagocytes / Q000276:immunology*
chemical_list: D008934:Mitogens