Cellular ATP content of heated Chinese hamster ovary cells.
Hyperthermia at either 41.5 or 45 degrees C with variable heating times to reduce cell survival up to three orders of magnitude did not decrease significantly cellular ATP content when measured either immediately or up to 7 hr after a heat treatment. Similarly, cellular ATP content was not significantly reduced with step-down heating, precooling prior to hyperthermia, or thermotolerance induction. The data suggest that heat-induced depletion of intracellular ATP content is not a critical factor in the thermal death of cells heated under normal culture conditions.
D000255:Adenosine Triphosphate / Q000032:analysis*; D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D006358:Hot Temperature; D010053:Ovary
D000255:Adenosine Triphosphate