Seminoma in a 46,XX true hermaphrodite with positive H-Y antigen. A case report.
This case study represents the first report of a 46,XX phenotypic male true hermaphrodite with a pure seminoma. Serologic testing of tissue demonstrated the presence of the H-Y antigen. This finding supports the theory that the H-Y gene is essential for primary sex determination and raises the possibility that it may also be the specific factor responsible for malignant degeneration of dysgenetic gonads.
D000328:Adult; D012734:Disorders of Sex Development / Q000235:genetics* / Q000276:immunology; D004407:Dysgerminoma / Q000235:genetics* / Q000276:immunology; D005260:Female; D006060:Gonadal Dysgenesis, Mixed / Q000235:genetics; D006182:H-Y Antigen / Q000032:analysis*; D006801:Humans; D007621:Karyotyping; D008297:Male; D010641:Phenotype; D012732:Sex Determination Analysis; D013085:Spermatic Cord; D014565:Urogenital Neoplasms / Q000235:genetics*
D006182:H-Y Antigen