[Analysis of uterine sarcoma induced in mice in terms of the two-staged development of tumors].
The results of combined treatment of CBA female mice with 1,2-dimethylhydrazine (DMH) and estradiol dipropionate (EP) are discussed in terms of a two-stage carcinogenesis hypothesis. 20% of mice treated with DMH alone developed uterine sarcomas. EP given after the cessation of DMH-treatment increased sarcoma incidence as high as 60.6% (5 micrograms EP) or 66.7% (10 micrograms EP) and significantly decreased the time of the first tumour appearance. From the standpoint of the two-stage carcinogenesis it is considered possible for EP to influence the tumour-initiating stage.
D019813:1,2-Dimethylhydrazine; D000818:Animals; D003043:Cocarcinogenesis; D004127:Dimethylhydrazines; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D011336:Probability; D012513:Sarcoma, Experimental / Q000139:chemically induced*; D013997:Time Factors; D014594:Uterine Neoplasms / Q000139:chemically induced*
D004127:Dimethylhydrazines; D004958:Estradiol; D019813:1,2-Dimethylhydrazine; C023482:estradiol dipropionate
Analiz indutsirovaniia sarkomy matki u mysheĭ s tochki zreniia gipotezy o dvukhstadiĭnom razvitii opukholeĭ.