Comparison between two non-absorbable antibiotic regimens for decontamination of the oropharynx.
Fourteen healthy individuals were studied regarding the oropharyngeal microflora. Seven subjects were given a non-absorbable multi-drug regimen, consisting of 1% polymyxin B, 3% neomycin and 3% amphotericin B, that was directed against aerobic gram-negative rods and fungi for local decontamination of the oropharynx. Seven others were given another multi-drug regimen consisting of 1% polymyxin B, 1% neomycin, 3% amphotericin B and 0.5% vancomycin, that also included an agent directed against gram-positive bacteria. Both decontamination regimens were found to protect from new colonization with fungi and gram-negative rods in the oropharynx. Suppression of gram-positive cocci was only observed in those subjects receiving the regimen containing vancomycin.
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects*; D004338:Drug Combinations; D005232:Fatty Acids, Volatile / Q000032:analysis; D005260:Female; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009355:Neomycin / Q000627:therapeutic use; D009960:Oropharynx / Q000382:microbiology*; D011112:Polymyxin B / Q000627:therapeutic use; D012463:Saliva / Q000032:analysis / Q000382:microbiology; D014640:Vancomycin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D005232:Fatty Acids, Volatile; D014640:Vancomycin; D000666:Amphotericin B; D009355:Neomycin; D011112:Polymyxin B