Improved method for the synthesis of phosphatidylcholines.
An improved method for the synthesis of phosphatidylcholines from phosphatidic acid and choline is described. The technique utilizes the tetraphenylborate salt of choline together with the condensing agent 2,4,6-triisopropylbenzenesulfonyl chloride. The yields in the reaction are consistently in the range 70-75%.
D055598:Chemical Phenomena; D002621:Chemistry; D002794:Choline; D004134:Dimyristoylphosphatidylcholine / Q000138:chemical synthesis; D010713:Phosphatidylcholines / Q000138:chemical synthesis*; D013775:Tetraphenylborate
D010713:Phosphatidylcholines; D013775:Tetraphenylborate; D002794:Choline; D004134:Dimyristoylphosphatidylcholine