HLA and filariasis in Sri Lankans and Indians.
Similar HLA association was found in patients with elephantiasis in Sri Lankans and Southern Indians. HLA-B15 was observed in 13/44 (30%) Sri Lankan patients with elephantiasis compared to 1/27 (4%) Sri Lankan controls (p = .0058; RR = 10.9) and in 5/8 (28%) Southern Indian elephantiasis compared to 10/101 (10%) Southern Indian controls (p = 0.04; RR = 3.5). In combining the data, the significance of the difference of the frequency of B15 between patients with elephantiasis and controls was even more marked (p = 0.00045; corrected p = 0.012; RR = 4.4).
D044466:Asian People; D004198:Disease Susceptibility; D004604:Elephantiasis / Q000235:genetics* / Q000276:immunology; D005260:Female; D005368:Filariasis / Q000235:genetics* / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008209:Lymphedema / Q000235:genetics*; D008296:Malaysia; D008297:Male; D012846:Singapore; D013188:Sri Lanka
D006680:HLA Antigens