Investigation on the carcinogenicity of emission condensate from brown coal-fired residential furnaces applied to mouse skin.
Flue gas condensate emitted from brown coal-fired stoves was tested in 3 dosages applied chronically to the skin of female CFLP mice twice a week over a period of 104 weeks. To answer the question which portion of the total carcinogenicity results from benzo[a]pyrene (BaP), this compound was taken as reference substance. The probit and Weibull analysis of the results showed a linear dose-response relationship for both tumor incidences and tumor induction times. The amount of BaP in the emission condensate (0.593 mg/g condensate) contributes about 15% to the total carcinogenic effect of the brown coal flue gas condensate.
D000393:Air Pollutants / Q000633:toxicity*; D000818:Animals; D001564:Benzo(a)pyrene; D003031:Coal / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006361:Heating / Q000009:adverse effects*; D051379:Mice; D008815:Mice, Inbred Strains; D012878:Skin Neoplasms / Q000139:chemically induced*; D013997:Time Factors
D000393:Air Pollutants; D003031:Coal; D001564:Benzo(a)pyrene