[Transketolase inhibitors based on disulfide derivatives of oxythiamine with branched hydrocarbon chains].
The experiments on mice have shown that oxythiamine disulphide derivatives with the branched hydrocarbon chains are less toxic in the organism as compared to oxythiamine and corresponding disulphides with the unbranched hydrocarbon chains and also induce a more pronounced inhibition of transketolase in the liver and other tissues. It is found that under the effect of the above substances the recovery of enzymic activity is slower than in the case with the oxythiamine application.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004220:Disulfides; D007928:Lethal Dose 50; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D010119:Oxythiamine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D013844:Thiazoles; D014174:Transketolase / Q000037:antagonists & inhibitors*
D004220:Disulfides; D013844:Thiazoles; D010119:Oxythiamine; D014174:Transketolase
Ingibitory transketolazy na osnove disul'fidnykh proizvodnykh oksitiamina s razvetvlennymi uglevodorodnymi tsepiami.