title: The behaviour of urokinase and porcine kidney cell plasminogen activator towards some synthetic peptides.
abstract: The behaviour of human urokinase and porcine kidney cell plasminogen activator towards some synthetic substrates has been investigated. Although N- benzyloxycarbonylglycylglycyl -L-arginine 4-methyl-7- coumarylamide (Z-Gly-Gly-Arg-Amc) (I), glutaryl-Gly-Arg-Amc (II) and Z-Gly-Gly-Arg-Val-OMe (III) were substrates, Boc-Gly-Gly-Arg-Val-Val-Gly-Gly-OEt (IV) and Z-Ala-Pro-Gly-Arg-Val-Val-Gly-Gly-OEt (V) were neither substrates nor inhibitors. Steady-state kinetic parameters for the hydrolysis of (II) and (III) by urokinase and porcine kidney cell plasminogen activator were similar.
mesh_terms: D000818:Animals; D003374:Coumarins / Q000378:metabolism; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007700:Kinetics; D009842:Oligopeptides / Q000378:metabolism*; D010960:Plasminogen Activators / Q000378:metabolism*; D013552:Swine; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism*
chemical_list: D003374:Coumarins; D009842:Oligopeptides; D010960:Plasminogen Activators; D014568:Urokinase-Type Plasminogen Activator