The role of the tubulointerstitial changes in the prognosis of IgA glomerulonephritis.
The authors investigated the tubulointerstitial changes (atrophic tubuli, interstitial fibrosis and round-cell infiltration) by two methods in renal biopsies from 56 patients with IgA glomerulonephritis. A statistically significant correlation was found to exist between the tubulointerstitial changes and serum creatinine level at the time of renal biopsy. A statistical significant correlation was also established between serum creatinine at the end of a period of 5 years of follow-up and tubulointerstitial changes. Their results suggest that severe tubulointerstitial lesions in IgA glomerulonephritis carry a poor prognosis.
D000293:Adolescent; D000328:Adult; D001706:Biopsy; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D005922:Glomerulonephritis, IGA / Q000473:pathology*; D006801:Humans; D007684:Kidney Tubules / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000473:pathology*; D011379:Prognosis
D003404:Creatinine