Comparison by nuclear angiography of resting left ventricular function in insulin-dependent diabetic patients and normal subjects and the effect of diabetic control.
Resting left ventricular ejection fraction (LVEF) was measured by nuclear angiography in 28 type 1 (insulin-dependent) diabetic patients and 31 control subjects. None had any clinical evidence of cardiac disease. The influence of age, duration of diabetes, plasma glucose (PG) and glycosylated haemoglobin (HbA1) levels at the time of testing was also assessed in a larger group of 52 type 1 diabetic patients. Resting LVEF was significantly lower in the diabetic patients, 0.46 +/- 0.11 (mean +/- SD), compared with the control subjects, 0.53 +/- 0.07 (p = 0.02). No significant correlation was found between resting LVEF and age, duration of diabetes, PG or HbA1 levels. While LV function may be abnormal in diabetic patients the causes are still unclear.
D000293:Adolescent; D000328:Adult; D002302:Cardiac Output; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D011877:Radionuclide Imaging; D013318:Stroke Volume; D013667:Technetium
D013667:Technetium