[Should we still explore placental sulfatase deficiencies? Reflections apropos of a case report].
The finding of low or very low levels of oestrogen during pregnancy should suggest the diagnosis of placental sulfatase deficiency, which is confirmed by performing dynamic biochemical tests. These biochemical tests also enable sulfatase deficiency to be differentiated from other conditions which may be accompanied by an abnormal decrease in oestrogens. The authors report one case and stress the harmlessness of sulfatase deficiency and the associated ichthyosis in boys and they question the value of the dehydroepiandrosterone sulfate test which only confirms an abnormality which is now well known and benign.
D000328:Adult; D004967:Estrogens / Q000097:blood; D005260:Female; D006801:Humans; D007057:Ichthyosis / Q000175:diagnosis* / Q000235:genetics; D007231:Infant, Newborn; D008297:Male; D010375:Pedigree; D010922:Placenta Diseases / Q000175:diagnosis*; D010927:Placental Insufficiency / Q000175:diagnosis* / Q000201:enzymology; D011247:Pregnancy; D013429:Sulfatases / Q000172:deficiency*
D004967:Estrogens; D013429:Sulfatases
Faut-il encore explorer les déficits en sulfatase placentaire? Réflexions à propos d'une observation.