The effects of Eimeria acervulina infection on the metabolism of chick duodenal tissue.
Broiler chicks, 2--3 weeks old were infected with eimeria acervulina, and the metabolism and ultrastructure of the infected duodenal tissue were studied during the period 3--14 days after inoculation (DAI). Between 4 and 5 DAI duodenal rings showed an increase in C-1/C-6 ratios of CO2 evolved from glucose as well as decreases in the rates of oxidation of glucose and octanoic acid. Between 4--7 DAI mitochondria from infected epithelial layers had reduced rates of octanoic acid and alpha-ketoglutaric acid oxidation as compared to controls. Electron microscopic observations confirmed the biochemical findings. At 5--6 DAI mitochondria in many uninfected cells were progressively swollen and then vacuolated as the cristae appeared to break down. Mitochondria in cells which contained parasites did not show these changes.
D000818:Animals; D002210:Caprylates / Q000378:metabolism; D002645:Chickens / Q000378:metabolism / Q000469:parasitology*; D003048:Coccidiosis / Q000378:metabolism / Q000473:pathology / Q000662:veterinary*; D004386:Duodenum / Q000378:metabolism* / Q000648:ultrastructure; D005947:Glucose / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism / Q000648:ultrastructure; D008928:Mitochondria / Q000378:metabolism / Q000648:ultrastructure; D010084:Oxidation-Reduction; D011201:Poultry Diseases / Q000378:metabolism* / Q000473:pathology
D002210:Caprylates; D005947:Glucose; C031492:octanoic acid