Double balanced de novo translocations involving chromosomes 4/15 and 5/12 in a mentally retarded boy.
This report describes a compound structural rearrangement containing two apparently unrelated reciprocal translocations, one between chromosomes 4 and 15, the other between 5 and 12. It is suggested that the patient's mental retardation and osteosclerosis may be the result of the loss of a small amount of chromosomal material and/or position effect accompanying these translocations.
D000293:Adolescent; D002901:Chromosomes, Human, 13-15; D002905:Chromosomes, Human, 4-5; D002906:Chromosomes, Human, 6-12 and X; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic