Mutachromosomal effects of tert-butylhydroquinone in bone-marrow cells of mice.
When given to mice either in a single ip injection of 200 mg/kg body weight or in 30 daily oral doses of 2 mg/kg, tert-butylhydroquinone had severe clastogenic effects on the bone-marrow cells. However mitostatic activity was observed only with the acute treatment.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D006873:Hydroquinones / Q000633:toxicity*; D008297:Male; D051379:Mice; D008938:Mitosis / Q000187:drug effects*
D006873:Hydroquinones; C018855:2-tert-butylhydroquinone