Choline uptake by lipid liposomes and its diffusion across chloroform are saturable and inhibited by hemicholinium-3.
Uptake of choline by lipid liposomes formed by cholate dialysis was saturable, inhibited by hemicholinium-3 and increased by preloading with unlabelled choline. Diffusion of choline between two aqueous phases separated by chloroform was also saturable, inhibited by high concentrations of hemicholinium-3, and increased by choline on the opposite side of the chloroform. These results indicate that choline diffusion may sometimes demonstrate properties qualitatively similar to those of low affinity carrier mediated transport systems.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002725:Chloroform; D002794:Choline / Q000378:metabolism*; D004058:Diffusion; D006426:Hemicholinium 3; D007700:Kinetics; D008081:Liposomes / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism
D008081:Liposomes; D010713:Phosphatidylcholines; D010743:Phospholipids; D006426:Hemicholinium 3; C024990:asolectin; D002725:Chloroform; D002794:Choline