Effect of carbanilate local anesthetics on granulation tissue formation.
The effect of local anesthetics pentacaine ((+/-)-trans N-/2-(3-pentyloxy-phenylcarbamoyloxy)-cyclohexyl/- pyrrolidinium chloride), heptacaine (N-/2-(2-heptyloxy-phenyl-carbamoyloxy)-ethyl/-piperidini um chloride) and trimecaine (2, 4, 6-trimethylphenylcarbamoyl)-methyldiethylammonium chloride) on granulation tissue formation in open skin wounds was examined in rats. The anesthetics applied on the wounds 3 times a day for 5 days caused increase in granulation tissue weight, in DNA and hydroxyproline contents. Pentacaine had the most pronounced effects (190% dry weight, 253% DNA and 148% hydroxyproline content when compared to saline-treated controls). The smallest changes were observed after heptacaine treatment.
D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D002219:Carbamates / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis; D006097:Granulation Tissue / Q000187:drug effects*; D006909:Hydroxyproline / Q000378:metabolism; D008297:Male; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014288:Trimecaine / Q000494:pharmacology; D014945:Wound Healing / Q000187:drug effects
D000779:Anesthetics, Local; D002219:Carbamates; D010880:Piperidines; C013549:heptacaine; C010618:pentacaine; D004247:DNA; D014288:Trimecaine; D006909:Hydroxyproline