title: The influence of dietary citrate on the absorption and retention of orally ingested lead.
abstract: The influence of dietary citrate on the toxicity of orally ingested lead was investigated in male weanling mice. Twenty-four animals were divided into three equal groups. Group 1 served as controls, groups 2 and 3 were given 20 micrograms lead (as lead acetate) per g/diet, group 3 also received 4% sodium citrate in the diet. After 5 weeks, blood and tissue lead levels were measured. All mice given lead-supplemented diets had higher concentrations of lead in blood, liver, kidney, brain and bone than the control group, but the increase was significantly greater in the group given 4% sodium citrate in the diet. This work demonstrated that dietary citrate at levels which can be present in food significantly increases lead toxicity.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002951:Citrates / Q000008:administration & dosage / Q000494:pharmacology*; D019343:Citric Acid; D004032:Diet; D007408:Intestinal Absorption / Q000187:drug effects*; D007854:Lead / Q000378:metabolism*; D008297:Male; D051379:Mice; D014018:Tissue Distribution
chemical_list: D002951:Citrates; D019343:Citric Acid; D007854:Lead