[Gastric emptying in the aged. Effect of clebopride].
Fifteen patients considered as "geronts" (average 70 years) have been performed Radiology, Endoscopy and Gastric Biopsies, with differents degrees of chronic gastritis as only gastric pathology, and 8 "healthy adults" (controls) were assessed on the T1/2 of gastric evacuation, with a solid meal marked with DPTA Tc 99 and measurement of isotopic activity in Gamma Camera before and after administration of a therapeutic dose of Clebopride. In the basal trial it was found that geronts gastric emptying is delayed more than controls (112 and 89 minutes). The activity of Clebopride revealed a significant decrease in both groups, being more important in geronts. This findings suggests the clinic usefulness in different pathological situations, where its useful to accelerate the time of gastric evacuation (gastric esofagic reflux, gastric ulcer) and in the geront with dispeptic symptoms and chronic gastritis related to age, as the only gastric pathology.
D000328:Adult; D000368:Aged; D000932:Antiemetics / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D005757:Gastritis, Atrophic / Q000503:physiopathology; D006801:Humans; D008297:Male; D004369:Pentetic Acid; D011877:Radionuclide Imaging; D013270:Stomach / Q000000981:diagnostic imaging
D000932:Antiemetics; D001549:Benzamides; D004369:Pentetic Acid; C014417:clebopride
Evacuación gástrica en el geronte. Acción del clebopride.