Methylation of protein and nucleic acids in vivo: use of trideuteromethylating agents or precursors.
Dose-dependent excretion of 7-(d3-methyl)guanine in rat urine was observed following administration by gavage of d6-aminopyrine and nitrite. Preliminary experiments showed that S-(d3-methyl)cysteine in haemoglobin is formed under the same dosing conditions that result in 7-(d3-methyl)guanine excretion in the urine.
D000818:Animals; D001345:Autoradiography; D002273:Carcinogens / Q000494:pharmacology*; D004247:DNA / Q000378:metabolism*; D004064:Digestive System / Q000187:drug effects / Q000378:metabolism; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D005849:Gerbillinae; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008745:Methylation; D051379:Mice; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; D011506:Proteins; D004247:DNA; C014707:nitrosobenzylmethylamine; D004128:Dimethylnitrosamine