Effects of high and low dosage of haloperidol on the brain in relation to schizophrenic thought disorder.
The drug difference between a low and a high dosage of haloperidol was investigated in 40 acutely ill schizophrenic patients. All patients were classified as being thought disordered or non-thought disordered schizophrenic using psychometric methods. From the pool of 40 patients two groups were randomly chosen for the double-blind study, one group receiving 80 mg of liquid haloperidol daily, the other group 16 mg of liquid haloperidol daily. On 5 days during the 21-day treatment the psychopathological state of the patient was evaluated by means of the AMDP system.
D006212:Hallucinations / Q000188:drug therapy; D006220:Haloperidol / Q000008:administration & dosage / Q000627:therapeutic use*; D006791:Hostility; D006801:Humans; D006998:Hypochondriasis / Q000188:drug therapy; D012559:Schizophrenia / Q000188:drug therapy*; D012563:Schizophrenia, Paranoid / Q000188:drug therapy; D012565:Schizophrenic Psychology; D013577:Syndrome; D013850:Thinking
D006220:Haloperidol