Isolation of monoclonal rheumatoid factors in hypergammaglobulinemic purpura.
Rheumatoid factors were isolated for immunochemical study by a simple procedure based on immunoadsorption after dissociation of immune complexes. A monoclonal IgA that was not detectable in the patient's unseparated serum was thus demonstrated in one case of hypergammaglobulinemic purpura whereas polyclonal anti-IgG antibodies were isolated in several patients with autoimmune diseases.
D000911:Antibodies, Monoclonal / Q000302:isolation & purification*; D006801:Humans; D007122:Immunoelectrophoresis; D007070:Immunoglobulin A / Q000302:isolation & purification; D007074:Immunoglobulin G / Q000302:isolation & purification; D008297:Male; D008875:Middle Aged; D011694:Purpura, Hyperglobulinemic / Q000276:immunology*; D012217:Rheumatoid Factor / Q000302:isolation & purification*
D000911:Antibodies, Monoclonal; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D012217:Rheumatoid Factor