title: [Determination of the parameters of the single 2-allele autosomal locus model with incomplete penetrance].
abstract: A method for estimating the parameters of the single autosomal two-allele locus model with incomplete penetrance (the gene frequency and penetrances of the three genotypes) is presented. The method requires the presence of (1) the population frequency of the trait; (2) any set of incidences in relatives of probands that would allow to obtain the estimations of additive and dominant genetic variances and (3) segregation frequencies determined by the generalized Weinberg's method. The method proposed yields the uniquel estimations of the model parameters for traits which have additive genetic variance differed from zero. Some aspects of practical use of the method are discussed.
mesh_terms: D000483:Alleles; D002877:Chromosomes, Human; D005787:Gene Frequency; D005799:Genes, Dominant; D014644:Genetic Variation; D005828:Genetics, Population; D005838:Genotype; D006801:Humans; D008433:Mathematics; D008957:Models, Genetic
vernacular_title: K voprosu ob opredelenii parametrov modeli odnogo autosomnogo dvukhallel'nogo lokusa s nepolnoĭ penetrantnost'iu.