Amputation neuroma of the orbit. Report of two cases and review of the literature.
Two patients developed proptosis and a slowly enlarging mass with increasing discomfort in the orbital socket 17 and 25 years following enucleation. Preoperative CT scans revealed a single cystic structure within the orbits of each case with distinct soft tissue tumors adjacent to the cysts. The cystic structures and the adjacent solid masses were removed en bloc necessitating reconstruction of the orbits with a dermal fat pad (case 1) and a mucous membrane graft (case 2). Postoperatively the patients were free of complaints. Microscopically, the cystic structures were identified as conjunctival inclusion cysts while the soft tissue masses were traumatic neuromas with irregular tangles and whorls composed of proliferated axons, Schwann cells and connective tissue. Only seven amputation neuromas of the orbit have been reported. Pain related to the neuroma is rarely encountered and is probably caused by mechanical irritation of the amputation neuroma, by retracting scar tissue, or compression from an adjacent cystic mass as in one of our cases.
D000328:Adult; D000671:Amputation, Surgical / Q000009:adverse effects*; D005128:Eye Diseases / Q000601:surgery; D005131:Eye Injuries / Q000601:surgery; D006801:Humans; D008297:Male; D009463:Neuroma / Q000209:etiology* / Q000473:pathology; D013508:Ophthalmologic Surgical Procedures; D009918:Orbital Neoplasms / Q000209:etiology* / Q000473:pathology; D014951:Wounds, Stab