[Changes in the hemostatic system and the progression of arteriosclerosis in ischemic heart disease patients].
The effect of standardized mental stress on the hemostatic system was studied in 160 patients with coronary heart disease. The diagnosis of coronary atherosclerosis was documented by selective coronary angiographic findings. Emotional tension was modelled using the method of counting with interswitching in conditions of time deficit, irritating light and sound signals, as well as critical remarks about the work performed. According to the protective-adaptive activation of the anti-clotting system, the patients were divided into two groups: 1 with activation of heparin activity of the blood and fibrinolysis, 2 with depressed fibrinolysis and lowered blood heparin. Prior to the onset of the study the patients of both groups exhibited hypercoagulation as compared with the control group. The maximum degree of hypercoagulation was observed in the second group patients. Hypercoagulative changes both at rest and under stress were shown to depend on the degree of coronary artery damage.
D000328:Adult; D001778:Blood Coagulation Disorders / Q000503:physiopathology; D001780:Blood Coagulation Tests; D017023:Coronary Angiography; D003327:Coronary Disease / Q000503:physiopathology*; D006487:Hemostasis; D006801:Humans; D008297:Male; D008875:Middle Aged; D013315:Stress, Psychological / Q000503:physiopathology
Izmeneniia sistemy gemostaza i progressirovanie ateroskleroza u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.