[Progress on the way to an "artificial liver"].
Recently lipophilic fluid membrane hollow fiber modules have been developed, which allow continuous extracorporal enzymatic detoxification by elimination of endogenous toxins out of the blood in vivo without loss of enzymatic activity and without immunological risks. The clearance for phenol glucuronisation is 6.8 nMol/min/mg enzyme protein/cm2 hollow fiber surface the hydroxylation rate for dodecanic acid using the cytochrome - P-450 system is 0.5 nMol/nMol P450/min/cm2 hollow fiber surface. Detoxification procedures using methyl, sulfat and glutathion transferase are still in an experimental phase. This new enzyme fluid membrane technology in conjunction with modified established techniques like aminoacid dialysis and plasma exchange will make possible the development of partial extracorporal substitution of liver function in the near future.
D000596:Amino Acids / Q000097:blood; D000818:Animals; D001187:Artificial Organs; D004798:Enzymes / Q000502:physiology; D005112:Extracorporeal Circulation / Q000295:instrumentation; D006498:Hepatectomy; D006501:Hepatic Encephalopathy / Q000628:therapy; D006801:Humans; D008099:Liver / Q000502:physiology*; D008103:Liver Cirrhosis / Q000628:therapy; D008115:Liver Regeneration; D008567:Membranes, Artificial; D011817:Rabbits
D000596:Amino Acids; D004798:Enzymes; D008567:Membranes, Artificial
Fortschritte auf dem Weg zur "künstlichen Leber".