15-Deacetylsergeolide, a potent antileukemic quassinoid from Picrolemma pseudocoffea.
Investigation of the leaf extract of Picrolemma pseudocoffea afforded a new antineoplastic quassinoid, 15-deacetylsergeolide (3), and two known quassinoids, isobruceine B (1) and sergeolide (2). The structure of 3, which displayed strong antileukemic activity in the P-388 test system, was established through the interpretation of spectral data and chemical correlation to 2.
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002621:Chemistry; D003460:Crystallization; D007941:Leukemia P388 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051379:Mice; D010616:Phenanthrenes / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000032:analysis
D000972:Antineoplastic Agents, Phytogenic; D010616:Phenanthrenes; C044994:15-deacetylsergeolide