title: Urinary androgen and 17-hydroxylated corticosteroid metabolites and their relation to recurrence rates in early breast cancer.
abstract: The amounts of urinary androsterone and etiocholanolone are highly correlated with recurrence rates in patients with early breast cancer after treatment by mastectomy. A more efficient means of predicting the clinical course of the disease is obtained by using a ratio of these compounds to the amounts of individual 17-hydroxycorticosteroids in the urine. For instance, the ratio of androsterone to alpha-cortolone is particularly effective in identifying women with a high rate of recurrence, and this is largely independent of pathological stage and tumor grade.
mesh_terms: D015065:17-Hydroxycorticosteroids / Q000652:urine*; D000328:Adult; D000368:Aged; D000728:Androgens / Q000652:urine*; D000738:Androsterone / Q000652:urine; D001943:Breast Neoplasms / Q000473:pathology / Q000601:surgery / Q000652:urine*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis* / Q000652:urine; D009367:Neoplasm Staging; D011278:Pregnanes / Q000652:urine; D011336:Probability; D011379:Prognosis
chemical_list: D015065:17-Hydroxycorticosteroids; D000728:Androgens; D011278:Pregnanes; C003545:cortolone; D000738:Androsterone