Protective effect of uridine on D-galactosamine-induced deficiency in brain uridine phosphates.
In the rat, 2 h after intraventricular application of 10 mumoles D-galactosamine as well as 10 and 20 mumoles uridine, opposite effects on brain content of UDP-glucose and uracil nucleotides were observed. While D-galactosamine caused a strong decrease in content of uridine phosphates, the brain content of the latter substances was markedly increased after uridine application. Furthermore, 20 mumoles uridine applied 10 min prior to D-galactosamine administration prevented the D-galactosamine-induced drop in brain uridine phosphates. The results are discussed in the light of behavioural findings in which D-galactosamine-induced impairment of retention performance of an acquired behaviour could be abolished by uridine pretreatment.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry; D005688:Galactosamine / Q000008:administration & dosage / Q000633:toxicity*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014500:Uracil Nucleotides / Q000172:deficiency*; D014529:Uridine / Q000494:pharmacology*
D014500:Uracil Nucleotides; D005688:Galactosamine; D014529:Uridine