title: Treatment of metritis with antibiotics or prostaglandin F2 alpha and influence of ovarian cyclicity in dairy cows.
abstract: From 4 dairy herds with a high prevalence of metritis, 153 cows with clinical metritis diagnosed at 30 days after calving were allotted randomly to 3 groups: (1) intrauterine antibiotics (chloramphenicol, framycetin) given in 3 doses, 1 week between doses (n = 53); (2) prostaglandin F2 alpha given IM in 2 doses, 14 days between doses (n = 61); and (3) control cows given a placebo (n = 39). To further evaluate the efficiency of the treatments, uterine swabs were prepared from 59 of the cows; Corynebacterium pyogenes was isolated in 51% of the cows. All isolated bacteria were susceptible to chloramphenicol and 85% to neomycin and related antibiotics (framycetin). The overall clinical recovery rates, estimated by 60 days after parturition, were identical (49%) in the 2 treated groups vs 33% in controls. The mean interval from calving to conception was 147 days in the controls and was shortened by 16 days in group 1 and 24 days in group 2. The physiologic status, ie, ovarian cyclicity, was shown to exert a significant influence on the time required for recovery. On the average, anestrous cows recovered in 14 days and conceived 34 days later than did cycling cows.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000503:physiopathology; D004716:Endometritis / Q000188:drug therapy / Q000382:microbiology / Q000503:physiopathology / Q000662:veterinary*; D004971:Estrus / Q000187:drug effects; D005260:Female; D010053:Ovary / Q000187:drug effects; D011247:Pregnancy; D011460:Prostaglandins F / Q000627:therapeutic use*; D014599:Uterus / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D011460:Prostaglandins F