[Effects of iodine deficiency during intrauterine and early postnatal life on DNA synthesis in liver and brain of rats].
Iodine deficiency during intrauterine and early postnatal life of the rat produces a transient decrease in the DNA content of brain and cerebellum, which is spontaneously recovered without replacement therapy. Results of the study revealed that DNA synthesis measured through thymidine-H3 incorporation to DNA, was increased at 21 days of life in liver, brain and cerebellum, indicative of a higher activity of DNA synthesis. This prolongation of the critical period of brain cell multiplication in iodine deficient rats, suggests, therefore, an alteration of brain maturation.
D000818:Animals; D001835:Body Weight; D001921:Brain / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis*; D004032:Diet; D005260:Female; D005333:Fetus / Q000378:metabolism*; D007455:Iodine / Q000172:deficiency*; D008099:Liver / Q000378:metabolism*; D009929:Organ Size; D011247:Pregnancy; D051381:Rats
D004247:DNA; D007455:Iodine
Effectos del déficit de yodo durante la vida intrauterina y postnatal precoz en la síntesis de ADN en hígado y encéfalo de ratas.