title: Single case experiments in psychopharmacological trials.
abstract: Single case experiments have been used to make pharmacotherapeutic decision making more objective. 4 single case experiments are presented. In the case of 3 patients the question was whether flunitrazepam (Rohypnol) should be administered. In the 4th patient the issue was whether self-administration of Limbitrol (amitriptyline + chlordiazepoxide) should be terminated. Planning and analysis of these experiments was carried out by the randomization test.
mesh_terms: D000328:Adult; D000639:Amitriptyline / Q000627:therapeutic use; D002707:Chlordiazepoxide / Q000627:therapeutic use; D002986:Clinical Trials as Topic / Q000379:methods*; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D005445:Flunitrazepam / Q000627:therapeutic use; D006331:Heart Diseases / Q000523:psychology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011600:Psychopharmacology / Q000379:methods*; D011602:Psychophysiologic Disorders / Q000188:drug therapy*; D011619:Psychotropic Drugs / Q000627:therapeutic use*; D011897:Random Allocation; D012893:Sleep Wake Disorders / Q000188:drug therapy*
chemical_list: D004338:Drug Combinations; D011619:Psychotropic Drugs; C001834:amitriptyline, chlordiazepoxide drug combination; D000639:Amitriptyline; D005445:Flunitrazepam; D002707:Chlordiazepoxide