Fatal hyperpyrexia after withdrawal of levodopa.
We studied a patient affected with idiopathic Parkinson's disease and levodopa-induced dyskinesias. Fatal hyperpyrexia followed simultaneous levodopa withdrawal and a decrease in the dosage of diphenhydramine. The clinical features were those of the neuroleptic malignant syndrome. The rapid decrease in dopaminergic activity may have been important in causing the syndrome.
D001480:Basal Ganglia Diseases / Q000139:chemically induced*; D004409:Dyskinesia, Drug-Induced / Q000503:physiopathology; D006801:Humans; D007980:Levodopa / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*
D007980:Levodopa