The contribution of on-bipolar cells to the electroretinogram of rabbits and monkeys. A study using 2-amino-4-phosphonobutyrate (APB).
We have obtained electroretinograms (ERGs) from rabbits and macaque monkeys after vitreal administration of 2-amino-4-phosphonobutyrate (APB), which selectively blocks light-responsiveness in retinal on-bipolar cells. Microelectrode recordings from central visual structures provided an independent measure of the drug effects. In rabbits, APB blocked the b-wave, a sustained corneal-positive potential, and a transient corneal-negative off-response. In monkeys, APB abolished the b-wave but had little or no effect on the d-wave. The d-wave could be eliminated, however, by the use of broadband blue stimuli. The results are discussed in light of recent hypotheses about the cellular origins of the ERG.
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004596:Electroretinography; D008253:Macaca mulatta; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D012160:Retina / Q000166:cytology* / Q000187:drug effects
D000613:Aminobutyrates; C012729:2-amino-4-phosphonobutyric acid