title: Retinoblastoma. CT diagnosis.
abstract: Computed tomography (CT) scan is a valuable adjunct in the differential diagnosis and management of retinoblastoma. Thirty-one of 33 retinoblastoma patients studied with high resolution computed tomography had intraocular calcification demonstrable in at least one eye. Over 80% of tumors showed evidence of calcification on CT scan. The degree of calcification appeared to depend upon tumor size; only small tumors were devoid of calcification. The amount and distribution of calcification was similar on both histological and CT review. In patients under three years of age in whom a retinoblastoma is suspected, the presence of calcification on CT scan is virtually diagnostic of retinoblastoma; patients with leukocoria without calcification on CT probably have a simulating lesion.
mesh_terms: D002114:Calcinosis / Q000150:complications / Q000000981:diagnostic imaging; D002675:Child, Preschool; D003937:Diagnosis, Differential; D005128:Eye Diseases / Q000150:complications / Q000000981:diagnostic imaging; D005134:Eye Neoplasms / Q000150:complications / Q000000981:diagnostic imaging*; D006651:Histocytochemistry; D006801:Humans; D007223:Infant; D009367:Neoplasm Staging; D011446:Prospective Studies; D012173:Retinitis / Q000000981:diagnostic imaging; D012175:Retinoblastoma / Q000150:complications / Q000000981:diagnostic imaging*; D014057:Tomography, X-Ray Computed; D014120:Toxocariasis / Q000000981:diagnostic imaging