Effects of treatments with apomorphine, haloperidol and ethanol on apomorphine-induced changes in body temperature in the rat.
In previous research, we discovered two DA-related thermoregulatory mechanisms in the rat: a haloperidol-sensitive, hypothermia-inducing mechanism and a haloperidol-nonsensitive, hyperthermia-inducing mechanism. The latter mechanism must also involve serotonin, since its activity can be blocked by serotonin antagonists. We have now found that the responsiveness of these mechanisms to apomorphine could be selectively affected by acute pretreatments with apomorphine, haloperidol and ethanol. The hypothermia-inducing mechanism was supersensitized by pretreatment with either haloperidol (0.25 mg/kg, administered 5 days earlier) or ethanol (3 g/kg, 15 h), but was not affected by pretreatment with apomorphine (1 mg/kg, 15h). In contrast, the hyperthermia-inducing mechanism was supersensitized and desensitized by similar pretreatments with apomorphine and ethanol, respectively, but was not affected by pretreatment with haloperidol.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001833:Body Temperature Regulation / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000431:Ethanol; D006220:Haloperidol; D001058:Apomorphine