title: [Effect of lyophilization on IgG aggregation processes in immunoglobulin preparations].
abstract: The conditions of the lyophilization of immunoglobulins as prescribed by the current technical regulations lead to the increased content of aggregated molecules in the preparation. The storage of the bulk preparation for two months after drying considerably decreases the content of aggregations. The authors believe it to be expedient to introduce the stage of storage after drying into the regulations for drying immunoglobulin preparations in the process of their production.
mesh_terms: D002850:Chromatography, Gel; D002855:Chromatography, Thin Layer; D005612:Freeze Drying / Q000379:methods; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000302:isolation & purification*; D013696:Temperature
chemical_list: D007074:Immunoglobulin G
vernacular_title: Vliianie liofilizatsii na protsessy agregatsii IgG v preparatakh immunoglobulinov.