Low-density lipoprotein metabolism by cultured human fibroblasts: relationship with aging and atherosclerosis.
22 male subjects aged 21-55 years with normal plasma lipid concentrations were divided into two groups on the basis of the presence or absence of proven coronary artery disease and/or peripheral vascular disease. The rates of uptake and degradation of low-density lipoprotein (LDL) by fibroblast cultures obtained from each subject were assessed using 125I-labelled LDL, and an attempt was made to relate them to the presence or absence of atherosclerosis and to the age of the subject. Atherosclerosis was found to be significantly correlated with elevated rates of LDL uptake and degradation. On the other hand, aging was shown to be associated with a significant reduction in cellular LDL metabolism.
D000328:Adult; D000375:Aging; D001161:Arteriosclerosis / Q000378:metabolism*; D001692:Biological Transport; D001706:Biopsy; D002478:Cells, Cultured; D006801:Humans; D007700:Kinetics; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012867:Skin / Q000378:metabolism*
D008077:Lipoproteins, LDL