Lymphocyte homing in mice: lack of significant alteration when H-2 antigen expression is moderately modified.
The part played by MHC antigens on lymphocyte homing has been investigated by inducing modifications of their expression on lymphoid cells. A significant, though moderate, enhancement of H-2 antigen expression has been observed following in vitro treatment of lymphocytes with alpha-IFN. A decrease has been obtained after in vivo treatment of mice with chloramphenicol. These rather moderate alterations of H-2 density (ca. 20-30%, as determined by cytofluorometry) did not induced changes of lymphocyte capacity to home into the different lymphoid organs.
D000818:Animals; D002465:Cell Movement; D002701:Chloramphenicol / Q000494:pharmacology; D006183:H-2 Antigens; D066298:In Vitro Techniques; D007370:Interferon Type I / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D006183:H-2 Antigens; D007370:Interferon Type I; D002701:Chloramphenicol