title: Influence of dietary casein or soy protein on serum lipids and lipoproteins of monkeys (Macaca fascicularis).
abstract: In order to learn whether a complete exchange of dietary soy protein for casein causes a change of serum lipid levels in primates, 8 Macaca fascicularis monkeys were fed a semi-purified ration; its basic composition was similar to diets consumed in Western Europe. In a crossover experiment, casein was exchanged for a soy protein isolate and vice versa. Plasma and lipoprotein cholesterol and triglyceride levels were determined following a 3-week dietary regimen. There was no significant difference of total serum cholesterol levels between the soy protein and casein periods (4.6 vs. 4.7 mmol/l). However, high-density lipoprotein (HDL) cholesterol levels were significantly higher (1.6 vs. 1.2 mmol/l, p less than 0.01) and very-low-density lipoprotein (VLDL) cholesterol levels were significantly lower (0.39 vs. 0.55 mmol/l, p less than 0.01) following the soy protein diet. There was no distinct change in total or lipoprotein triglyceride levels following exchange of the dietary protein. It is concluded that in nonhuman primates a complete exchange of soy protein for casein produces changes of HDL, but not of total or low-density lipoprotein (LDL) cholesterol.
mesh_terms: D000818:Animals; D002364:Caseins / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D004044:Dietary Proteins / Q000494:pharmacology*; D005260:Female; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood; D008252:Macaca fascicularis; D008297:Male; D014674:Plant Proteins, Dietary / Q000494:pharmacology; D013025:Glycine max; D014280:Triglycerides / Q000097:blood
chemical_list: D002364:Caseins; D004044:Dietary Proteins; D008055:Lipids; D008074:Lipoproteins; D014674:Plant Proteins, Dietary; D014280:Triglycerides; D002784:Cholesterol