In vivo and in vitro pharmacokinetics and fate of furaltadone in meat- and milk-producing animals.
The metabolism of furaltadone was examined by an in vitro hepatic study in cows and goats and an in vivo study in goats using 14C-labeled and unlabeled drug. The half-life of furaltadone was 13 min in the homogenates of caprine and bovine liver and 35 min in the in vivo study of the goat. Less than 2% of the parent drug was present in the urine of animals dosed either intravenously or intramammarily. No furaltadone was detected in the milk after 24 h. Overall, the parent compound was rapidly absorbed, distributed, and widely degraded in the lactating goat. The compound, labeled at the 2-formyl carbon of the furan ring, had a radioactivity recovery of 81% in the feces and urine. Of the total radioactivity, 99.4% infused into the udder had been absorbed after 72 h. Tissue distributions of radioactivity in decreasing order of abundance were: kidney, udder, liver, duodenum, muscular tissue, adipose tissue, and bile.
D000818:Animals; D002417:Cattle; D005260:Female; D006041:Goats; D066298:In Vitro Techniques; D007700:Kinetics; D007774:Lactation; D008099:Liver / Q000378:metabolism; D008460:Meat; D008892:Milk; D009581:Nitrofurans / Q000378:metabolism* / Q000652:urine; D023303:Oxazolidinones; D011247:Pregnancy; D013997:Time Factors; D014018:Tissue Distribution
D009581:Nitrofurans; D023303:Oxazolidinones; C007795:furaltadon