[Derivatives of 2-thiocyanobenzoic acid with antifungal activity].
A series of amides, esters and thioesters of 2-thiocyanobenzoic acid were synthesised and tested for antifungal activity in vitro and in vivo against various strains of fungus pathological to plants. The phytotoxicity against representative plants was studied in parallel. The substances were prepared by condensation of suitable mercaptobenzamides with cyanogen bromide or of 2-thiocyanobenzoyl chloride with amines, alcohols or mercaptans. This research showed in vitro antifungal activity of some N-monosubstituted amides and in vivo activity of some N-monosubstituted and N,N-disubstituted amides of 2-thiocyanobenzoic acid which have the same protective activity towards P. viticola as Zineb.
D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis*; D001565:Benzoates / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D008930:Mitochondria, Liver / Q000187:drug effects; D009181:Mycoses / Q000188:drug therapy; D051381:Rats; D013329:Structure-Activity Relationship; D013861:Thiocyanates / Q000138:chemical synthesis* / Q000494:pharmacology
D000935:Antifungal Agents; D001565:Benzoates; D013861:Thiocyanates
Derivati dell'acido 2-tiocianobenzoico ad attività antifungina.