Effect of venous stasis on vessel wall fibrinolysis.
The effects of prolonged venous stasis on release of plasminogen activators (PA) from the caval vein of rats were studied. PA activity was continuously reduced in the intimal layer and after 8 hr of stasis the reduction was statistically significant. After 2 and 3 days no intimal PA activity was found. The PA activity in the adventitial vasa vasorum was unchanged during the experimental period.
D000818:Animals; D004727:Endothelium / Q000378:metabolism; D005342:Fibrinolysis; D008297:Male; D010960:Plasminogen Activators / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013924:Thrombophlebitis / Q000097:blood*; D014682:Vena Cava, Inferior / Q000378:metabolism; D014689:Venous Insufficiency / Q000097:blood*
D010960:Plasminogen Activators