[Radiomodifying effect of glucose load on oxygenated and hypoxic tumor cells].
A study was made of the radiomodifying effect of the glucose load on the oxygenated and hypoxic cells of Ehrlich's ascites carcinoma (EAC) in vitro. It has been shown that EAC cells actively utilize glucose causing a decrease in pH cell suspensions. Under hypoxia conditions it was slightly more pronounced than under oxygenation conditions (up to 5.2 and 5.6 respectively). The incubation of EAC cells with glucose prior to and after irradiation under hypoxia conditions enhances, to a great extent, their radiation injury: effect modifying factor (EMF) exceeds 3.5. The volume of the modification with the glucose load of the lethal effect of irradiation on EAC cells varies with EMF from 1.1. to 1.5.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism / Q000532:radiotherapy*; D002478:Cells, Cultured; D004307:Dose-Response Relationship, Radiation; D005947:Glucose / Q000494:pharmacology*; D051379:Mice; D009368:Neoplasm Transplantation; D010101:Oxygen Consumption / Q000187:drug effects* / Q000528:radiation effects; D011836:Radiation Tolerance
D005947:Glucose
Radiomodifitsiruiushchee deĭstvie gliukoznoĭ nagruzki na oksigenirovannye i gipoksicheskie opukholevye kletki.