Application of the simple mathematical function for the quantitative description of in vitro release of drug agents from the ointment bases.
An attempt of the quantitative description of the release process by the simple mathematical functions has been made. It was found that the hyperbolic function q = t/(A + Bt) is the best for this application. The values of the parameters 1/A and 1/B are proportional to the released amounts of drug, so they can be useful for the evaluation of the rate of the release process.
D002626:Chemistry, Pharmaceutical; D007700:Kinetics; D008433:Mathematics; D008956:Models, Chemical; D009823:Ointment Bases / Q000032:analysis*; D010592:Pharmaceutic Aids / Q000032:analysis*; D004364:Pharmaceutical Preparations / Q000032:analysis*
D009823:Ointment Bases; D010592:Pharmaceutic Aids; D004364:Pharmaceutical Preparations