Interaction of povidone with aromatic compounds V: Relationship of binding tendency in a macromolecular solution treated as a pseudo two phase and a monophase.
The pseudo-two-phase model is proposed to correlate complex formation of ligand molecules with povidone with partition coefficients (log P or II constants). The conditions which permit the use of the pseudo-two-phase model for binding of ligand onto macromolecules are determined. This model seems to be a more rational choice than the frequently used complex formation model (monophase). This is demonstrated theoretically and confirmed experimentally. The advantages of the use of such a model are also discussed.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D046911:Macromolecular Substances; D011205:Povidone; D012459:Salicylates; D020156:Salicylic Acid; D012995:Solubility; D012996:Solutions; D014462:Ultrafiltration
D046911:Macromolecular Substances; D012459:Salicylates; D012996:Solutions; D011205:Povidone; D020156:Salicylic Acid