The effect of beta-blockade on gastric acid secretion, gastrin release, and plasma catecholamine concentrations during modified sham feeding in duodenal ulcer patients.
The effects of beta-blockade (propranolol, 100 mg orally) on gastric acid output and on circulating levels of gastrin, adrenaline, noradrenaline, and dopamine during modified sham feeding (MSF) were investigated by a randomized, double-blind method in six patients with asymptomatic duodenal ulcer disease. No differences occurred in peak acid output during MSF, whereas basal acid output was significantly suppressed by beta-blockade and peak acid output was unaffected. Basal gastrin concentration was lower during beta-blockade but rose in response to MSF. Without beta-blockade serum gastrin levels were unaffected by MSF. Plasma catecholamine concentrations were not affected by the beta-blockade. It is concluded that acid output and gastrin release in response to MSF, unlike that to insulin hypoglycaemia, is not influenced by beta-adrenoceptor blockade.
D000328:Adult; D002395:Catecholamines / Q000097:blood*; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000378:metabolism*; D005260:Female; D005502:Food; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000627:therapeutic use*; D012636:Secretory Rate / Q000187:drug effects
D002395:Catecholamines; D005755:Gastrins; D011433:Propranolol