Comparison of the elimination and metabolism of 10% Travamulsion and 10% Intralipid lipid emulsion in the dog.
A study was performed comparing the elimination kinetics of two soybean oil/egg phosphatide lipid emulsions (10% Travamulsion vs 10% Intralipid) from the vascular compartment of the dog. Elimination kinetics were evaluated after bolus injection and after continuous infusion studies. Evaluation of triglyceride and free fatty acid data indicates the emulsions are similar metabolic substrates. Phospholipid and cholesterol data indicate a possible difference in remnant particle removal. At the higher lipid dosages, remnant particles from Travamulsion injection were removed at a faster rate than those from Intralipid.
D000818:Animals; D002784:Cholesterol / Q000097:blood; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004655:Emulsions; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007700:Kinetics; D008055:Lipids / Q000097:blood*; D010743:Phospholipids / Q000097:blood; D013024:Soybean Oil; D014280:Triglycerides / Q000097:blood
D004655:Emulsions; D005217:Fat Emulsions, Intravenous; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D010743:Phospholipids; D014280:Triglycerides; C545823:soybean oil, phospholipid emulsion; D013024:Soybean Oil; D002784:Cholesterol