Species-dependent differences in the nature of endothelium-derived vascular relaxing factor.
Effluents from perfused acetylcholine-relaxed endothelium segments of rabbit aorta (or canin femoral artery) contained endothelium-derived relaxing factors (EDRF) which dilated the endothelium-free segments of rabbit femoral artery (or side branches of canine femoral artery). The half-life of EDRF was 24 +/- 3 s for the rabbit and 49 +/- 5 s for the canine system. Nordihydroguaiaretic acid was less effective against the formation of canine EDRF than of rabbit EDRF. These findings suggest species differences in the nature of EDRF.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001681:Biological Assay; D001808:Blood Vessels / Q000032:analysis*; D004285:Dogs; D004727:Endothelium / Q000032:analysis; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D011817:Rabbits; D013045:Species Specificity; D014665:Vasodilator Agents / Q000032:analysis* / Q000378:metabolism
D014665:Vasodilator Agents; D000109:Acetylcholine