Morphologic changes of the esophageal mucosa in the rat after chronic alcohol ingestion.
Fifteen litter-matched pairs of Sprague-Dawley rats were divided into two groups, one fed an alcoholic diet and the other fed an isocaloric but non-alcoholic diet. 5 animals each of the experimental and control groups were sacrificed at 98, 200 and 290 d. The upper part of esophagus was fixed for morphological analysis of semi-fine sections. The following histological observations were made on the oral-esophageal mucosa of the alcohol-consuming animals: An epithelial atrophy was observed between 200 and 290 d of alcoholisation . This atrophy was not the result of a decrease in the number of epithelial layers, but was associated with a decrease in basal cellular size. A basal cell pleomorphism and a tendency towards epithelial dysplasia were the rule after long time alcohol consumption. These observations reflect features resembling to those seen in Plummer- Vinson syndrome, a precancerous state in humans.
D000437:Alcoholism / Q000473:pathology*; D000818:Animals; D004848:Epithelium / Q000473:pathology; D004947:Esophagus / Q000473:pathology*; D005260:Female; D006801:Humans; D009092:Mucous Membrane / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains