Influence of cerebral spinal fluid on the affinity of human red cells for oxygen.
The oxygen affinity of washed red cells suspended in their own plasma or in CSF has been studied to demonstrate a possible effect of CSF on the oxygen affinity of human haemoglobin. The CSF was found to reduce the oxygen affinity of haemoglobin significatively, and this was not imputable to the action of pH, PCO2, temperature, 2,3DPG A hypothesis to explain the data found and their clinical interest towards the regulation of brain oxygenation was formulated considering the Monod-Wyman-Changeux model and the effect of solutions on proteins.
D000328:Adult; D002555:Cerebrospinal Fluid / Q000502:physiology*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010100:Oxygen / Q000378:metabolism*; D010108:Oxyhemoglobins / Q000378:metabolism*
D010108:Oxyhemoglobins; D010100:Oxygen