Nifedipine has no effects on electrolytic equilibrium and hemoglobin oxygen affinity of human blood in vitro.
The in vitro effects of solutions of nifedipine on hemoglobin-oxygen affinity and electrolyte distribution between plasma and red cells were evaluated. Nifedipine did not show any effect on P50, nor in function of plasmatic pH, nor in function of intraerythrocytic pH. Red cell content of 2,3 DPG remained unchanged. There were no shifts of Na+, K+, Ca++ and Cl- between plasma and red cells.
D004910:Erythrocyte Membrane / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D009543:Nifedipine / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D006454:Hemoglobins; D009543:Nifedipine; D010100:Oxygen