Cellular radiosensitivity: expression of an MS susceptibility gene?
As a group, of 40 MS patients exhibited significantly more cellular sensitivity to ionizing (gamma) radiation than 30 age- and sex-matched controls (p less than 0.0001), as measured by radiation-induced chromosome aberrations. Studies of phytohemagglutinin-stimulated T lymphocytes, B lymphoblastoid cell lines, and fibroblasts indicated that the cellular radiosensitivity was a general property of the cells of an individual. Patterns of cellular radiosensitivity among the unaffected first-degree relatives of some MS patients suggested autosomal dominant inheritance. Cellular radiosensitivity may be due to mutations of DNA-processing that predispose to MS.
D002869:Chromosome Aberrations; D004247:DNA / Q000528:radiation effects; D004198:Disease Susceptibility; D005260:Female; D005799:Genes, Dominant / Q000528:radiation effects*; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics*
D004247:DNA