title: Dysfibrinogenaemia associated with a defect in the aggregation of the fibrin monomers (Almeria I fibrinogen). A preliminary study.
abstract: A patient with functionally defective fibrinogen has been studied. Fibrinogen Almeria I was found to have a prolonged of latency time (LT) and a decrease in rate of gelation (RG) when plasma or isolated fibrinogen were activated by thrombin or reptilase. This fibrinogen also has the unusual formation of cross-linked fibrin; the existence of unpolymerized alpha chains was confirmed.
mesh_terms: D000328:Adult; D012103:Batroxobin / Q000378:metabolism; D001778:Blood Coagulation Disorders / Q000097:blood*; D005260:Female; D005337:Fibrin / Q000032:analysis*; D005340:Fibrinogen / Q000032:analysis*; D015241:Fibrinogens, Abnormal; D006801:Humans; D011108:Polymers / Q000032:analysis; D013918:Thrombin Time
chemical_list: D015241:Fibrinogens, Abnormal; D011108:Polymers; C044205:fibrinogen Almeria I; D005337:Fibrin; D005340:Fibrinogen; D012103:Batroxobin