[Total vagal deafferentation and gastric emptying in swine].
50-kg pigs fed a purified wheat starch and casein diet were fitted with a gastric cannula. Gastric emptying was studied by checking the residual gastric contents at 30 min and 1, 2, 4 and 7 hrs after feeding. Five of the 25 pigs were used as controls; 5 were submitted to total vagal deafferentation including removal of the left nodose ganglion, right truncal vagotomy at the diaphragm and resection of the interconnecting branches between the two vagi on their intrathoracic course; 5 were submitted to total contralateral vagal deafferentation; 5 only underwent left truncal vagotomy and resection of the connectives; 5 were submitted to the contralateral operation. Total vagal deafferentation, suppressing bilateral afferences originating below the diaphragm, resulted in much higher residual gastric contents at all times studied after the meal. Significant gastric retention was also observed after unilateral truncal vagotomy as compared to the controls. Nevertheless, this retention was significantly lower than after total deafferentation. The reduced emptying rate after total vagal deafferentation was a result of the loss of all afferences, while the simultaneous reduction of efferences was of little importance. The mechanisms responsible for gastric retention have been discussed in relation with the sustained antral hyperactivity previously found in deafferented pigs and with the various controls of gastric emptying. Several factors may be involved, including both motor and secretory changes. The prolonged postprandial activity of the gastric antrum seemed to be a consequence of gastric retention.
D000821:Animal Feed; D000818:Animals; D005746:Gastric Emptying; D008297:Male; D009475:Neurons, Afferent / Q000502:physiology; D013552:Swine / Q000502:physiology*; D013997:Time Factors; D014628:Vagotomy / Q000662:veterinary; D014630:Vagus Nerve / Q000502:physiology*
Déafférentation vagale totale et évacuation gastrique chez le porc.