title: Time course of thyroglobulin autoantibodies in patients with differentiated thyroid carcinoma after radioiodine therapy.
abstract: The time course of thyroglobulin (Tg) was monitored in patients with differentiated thyroid carcinoma after ablative therapy (thyroidectomy + 131I-treatment) with particular respect to endogeneous antibodies (Tg-ABs). In 232 patients (196 without Tg-ABs, 36 with Tg-ABs at the time of treatment) a sensitivity of 88% (accuracy, 93%) was found at the first follow up examination. Twelve months later, 11 of the 36 patients did not present Tg-ABs, therefore, the sensitivity increased to 91% (accuracy, 94%) at that time. It is expected that the determination of Tg can also be employed in patients presenting ABs initially.
mesh_terms: D001323:Autoantibodies / Q000032:analysis*; D002277:Carcinoma / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery; D003131:Combined Modality Therapy; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D011863:Radioimmunoassay; D013954:Thyroglobulin / Q000032:analysis*; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000532:radiotherapy* / Q000601:surgery; D013965:Thyroidectomy; D013997:Time Factors
chemical_list: D001323:Autoantibodies; D007457:Iodine Radioisotopes; D013954:Thyroglobulin