Penicillamine-induced pemphigus. Immunoglobulin from this patient induces plasminogen activator synthesis by human epidermal cells in culture: mechanism for acantholysis in pemphigus.
The incubation of cultured epidermal cells with IgG obtained from a 56-year-old man with penicillamine-induced pemphigus resulted in an increase in extracellular and intracellular plasminogen activator. This suggests that penicillamine-induced pemphigus and spontaneously occurring pemphigus share common pathophysiologic processes in the induction of blister formation.
D000051:Acantholysis / Q000209:etiology; D002478:Cells, Cultured; D004817:Epidermis; D006801:Humans; D007074:Immunoglobulin G / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000139:chemically induced* / Q000276:immunology / Q000378:metabolism; D010396:Penicillamine / Q000009:adverse effects*; D010960:Plasminogen Activators / Q000096:biosynthesis*
D007074:Immunoglobulin G; D010960:Plasminogen Activators; D010396:Penicillamine