Carcinogenicity in rats of ptaquiloside isolated from bracken.
The nature of the carcinogen present in bracken fern has not yet been elucidated. Very recently, we succeeded in isolating ptaquiloside, a novel norsesquiterpene glucoside of the illudane type, from bracken. Ptaquiloside was shown to be a carcinogenic principle of bracken fern. It induces mammary cancer and multiple ileal tumors in high incidences when given orally to female Sprague-Dawley rats.
D000818:Animals; D002273:Carcinogens / Q000302:isolation & purification*; D005260:Female; D007078:Ileal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D007189:Indans; D008325:Mammary Neoplasms, Experimental / Q000473:pathology*; D010944:Plants; D051381:Rats; D011919:Rats, Inbred Strains; D012717:Sesquiterpenes; D013729:Terpenes / Q000302:isolation & purification* / Q000633:toxicity
D002273:Carcinogens; D007189:Indans; D012717:Sesquiterpenes; D013729:Terpenes; C043680:ptaquiloside