Steroid effects on uveal transport.
Hydrocortisone (10(-4)M) causes a significant depression of cholic acid accumulation by the isolated rabbit ciliary body-iris while causing little, if any, depression of p-aminohippuric acid uptake and not affecting alpha-aminoisobutyric acid uptake. Because no lag period is present for this inhibition and because cyclohexamide pretreatments fails to eliminate it, the hydrocortisone effect does not appear to be mediated by a protein synthesis mechanism. Deoxycorticosterone (10(-4)M) not only inhibits cholic acid uptake but also depresses p-aminohippuric acid uptake; no deoxycorticosterone effect on alpha-aminoisobutyric acid uptake is seen.
D000621:Aminoisobutyric Acids; D000818:Animals; D001692:Biological Transport; D019826:Cholic Acid; D002793:Cholic Acids / Q000378:metabolism; D003900:Desoxycorticosterone / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology*; D006854:Hydrocortisone / Q000494:pharmacology*; D011817:Rabbits; D014602:Uvea / Q000378:metabolism*; D010130:p-Aminohippuric Acid / Q000378:metabolism
D000621:Aminoisobutyric Acids; D002793:Cholic Acids; C100049:2-aminoisobutyric acid; D003900:Desoxycorticosterone; D003907:Dexamethasone; D019826:Cholic Acid; D006854:Hydrocortisone; D010130:p-Aminohippuric Acid