Lack of effect of bretylium tosylate on electrical ventricular defibrillation in a controlled study.
The threshold stored energy and transthoracic current for electrical defibrillation were determined in dogs anaesthetised with pentobarbitone. Groups were randomly allocated to pre-treatment with either saline or bretylium. The intravenous administration of bretylium tosylate (10 to 30 mg . kg-1) did not significantly alter either measurement. The drug caused large changes in heart rate and arterial blood pressure.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001949:Bretylium Compounds / Q000494:pharmacology*; D001950:Bretylium Tosylate / Q000494:pharmacology*; D004285:Dogs; D004553:Electric Conductivity; D004554:Electric Countershock; D006321:Heart / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D011897:Random Allocation; D013909:Thorax / Q000502:physiology
D001949:Bretylium Compounds; D001950:Bretylium Tosylate