Tinidazole prophylaxis in elective colorectal surgery.
Bowel wall concentrations of tinidazole in two patient groups undergoing elective colorectal surgery were determined 8 h (22 patients) and 12 h (26 patients) after a single 500-mg intravenous infusion. In addition, the efficacy of 1-day tinidazole prophylaxis with 8- and 12-h dosage intervals in the prevention of postoperative infection complications was evaluated. The mean bowel wall tinidazole concentrations 8 and 12 h after infusion were 5.1 +/- 2.5 micrograms/g and 4.3 +/- 1.8 micrograms/g, respectively, which are considerably higher than the minimal inhibitory concentration for Bacteroides fragilis strains. Three patients out of 48 (6.3%) developed a wound infection: 1 from the 8-h dosage interval group (4.5%) and 2 from the 12-h interval group (7.7%). Wound cultures revealed only aerobic growth. The results confirm that an adequate bowel wall concentration remains for more than 12 h after a single 500-mg intravenous infusion of tinidazole. One-day tinidazole prophylaxis is an effective means of preventing postoperative infections after colorectal surgery.
D000328:Adult; D000368:Aged; D003108:Colonic Diseases / Q000601:surgery*; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009593:Nitroimidazoles / Q000627:therapeutic use*; D011292:Premedication; D012002:Rectal Diseases / Q000601:surgery*; D013530:Surgical Wound Infection / Q000382:microbiology / Q000517:prevention & control*; D014011:Tinidazole / Q000032:analysis / Q000627:therapeutic use*
D009593:Nitroimidazoles; D014011:Tinidazole