[Serum immunoglobulins in diabetic and healthy pregnant patients and their newborn infants].
The immunoglobulin G, A, and M levels in maternal serum sampled at delivery and in umbilical cord serum of diabetic and normal pregnant women and their newborns had been estimated and compared. The aim of the diabetic control was to achieve normoglycemic blood glucose levels during pregnancy. IgG and IgM of diabetics were significantly lower, IgA levels were comparable to normal pregnant women. Excluding the 39th week gestation however both series of newborns divided in groups of same gestational age had comparable immunoglobulin levels. The data are discussed with those of other authors. According to these results immunological host defense due to placental IgG transport and fetal production of IgA and IgM in infants of well-controlled pregnant diabetics can be considered to be comparable to those of normal pregnant women.
D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics / Q000276:immunology*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007136:Immunoglobulins / Q000378:metabolism*; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000276:immunology*
D007136:Immunoglobulins
Serum-Immunglobuline bei diabetischen und gesunden Schwangeren und deren Neugeborenen.