title: [Genetics of congenital esophageal defects].
abstract: An analysis of 304 cases of esophageal atresia in fetuses and neonates showed that frequency of other congenital malformations is 43.1% including 10% of chromosomal disorders and monogenous syndromes. Summarizing the authors' own data and evidences from literature the genetic risk for sibs is calculated to be 0.88% and heredity--57.3 +/- 5.1%. The hypothesis that esophageal atresia is a malformation of multifactorial genesis with polygenic hereditary component is confirmed.
mesh_terms: D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D004933:Esophageal Atresia / Q000235:genetics*; D004940:Esophageal Stenosis / Q000235:genetics; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D012306:Risk; D014138:Tracheoesophageal Fistula / Q000235:genetics
vernacular_title: Genetika vrozhdennykh porokov pishchevoda.