[Effect of diets of different isomer composition of fatty acids on the blood vessel wall, blood lipids and platelet aggregation].
It was established in rat experiments that prolonged (4.5 months) use of the diet with a high content of spatial (trans-) and positional isomers of fatty acids exerted an adverse effect on the laboratory animals. They showed the impairment of the hemostasis integrity; namely of the walls of blood vessels (aorta, intraorgan arteries of the heart and kidneys), blood lipids, fatty acid composition and aggregation properties of platelets. The animals developed alterations similar to those occurring with the use of the diets rich in saturated fatty acids. The vessels manifested dystrophic alterations of elasticity and smooth muscle cells, whereas blood an increase in the content of atherogenic lipoproteins associated with a high content of total lipids and cholesterol. The ADP-induced enhancement of platelet aggregation was observed in experiments in vitro.
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology; D001808:Blood Vessels / Q000473:pathology*; D004041:Dietary Fats / Q000008:administration & dosage* / Q000009:adverse effects; D004547:Elastic Tissue / Q000473:pathology; D005227:Fatty Acids / Q000008:administration & dosage* / Q000009:adverse effects; D008055:Lipids / Q000097:blood*; D009131:Muscle, Smooth, Vascular / Q000473:pathology; D010974:Platelet Aggregation; D051381:Rats; D013237:Stereoisomerism
D004041:Dietary Fats; D005227:Fatty Acids; D008055:Lipids
Vliianie ratsionov s razlichnym izomernym sostavom zhirnykh kislot na stenku krovenosnykh sosudov, lipidy krovi i agregatsiiu trombotsitov.