title: [Progression of coronary sclerosis. Studies in 19 patients over a 6-year period using quantitative coronary angiography].
abstract: The characteristics of progressive coronary artery disease as judged from sequential angiography were quantitatively analysed in 19 patients with stable angina in whom coronary angiograms were repeated after 64-104 months (average 76.5 months). The diameters of at most 15 corresponding segments were measured with a vernier caliper (accuracy: 0.05 mm) at identical sites and in the same projections. Considering the error in measurement (less than 10%) and spontaneous changes in smooth muscle tone only a diameter decrease of greater than 20% and/or every transition to an occlusion were recorded as progression. The progression over a 6-year interval was predominately characterized by: A large amount of total occlusions (61% of all progressive stenoses), relatively independent of the initial degree of stenosis. A large amount of newly developed obstructions which are more severe in coronary arteries already segmentally diseased at the onset, indicating a diffuse intramural disease of the entire vessel. A different pattern of progression in the 3 main coronary arteries. No influence of risk factors on natural history.
mesh_terms: D000787:Angina Pectoris / Q000000981:diagnostic imaging; D003251:Constriction, Pathologic / Q000000981:diagnostic imaging; D017023:Coronary Angiography; D003327:Coronary Disease / Q000000981:diagnostic imaging*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging; D012306:Risk
vernacular_title: Zur Progression der Koronarsklerose. Untersuchungen bei 19 Patienten über 6 Jahre mittels quantitativer Koronarangiographie.