title: [Methodologic references for clinical function diagnosis of glomerular permeability selectivity by molecular wight related protein analysis and additional para-aminohippuric acid load].
abstract: Glomerular perm selectivity can be approximately estimated from the apparent glomerular protein clearance in terms of molecular weight since the relative protein clearance is approximately identical with the corresponding screen coefficient relation. Systematic relativization of individual protein clearances by reference to albumin (or transferrin) clearance requires the application of special calculations to find out the regression coefficients relevant to functional diagnosis. A PAH load influences tubular protein reabsorption so that the clearance of higher-molecular proteins (IgA alpha 2-macroglobuli, IgM) rises. Taking the changes in protein clearance under renotubular PAH load into account allows a more precise estimation of glomerular permeability to be made, in comparison with protein analyses not using PAH load.
mesh_terms: D000618:Aminohippuric Acids; D002199:Capillary Permeability; D005919:Glomerular Filtration Rate; D006801:Humans; D007677:Kidney Function Tests / Q000379:methods*; D007678:Kidney Glomerulus / Q000503:physiopathology; D007684:Kidney Tubules / Q000503:physiopathology; D008970:Molecular Weight; D011507:Proteinuria / Q000175:diagnosis* / Q000503:physiopathology; D010130:p-Aminohippuric Acid
chemical_list: D000618:Aminohippuric Acids; D010130:p-Aminohippuric Acid
vernacular_title: Methodologische Hinweise zur klinischen Funktionsdiagnostik der glomerulären Permselektivität durch molekulargewichtsbezogene Proteinanalyse und zusätzlicher Paraamonohippursäure-Belastung.