Comparison of adrenergic receptor binding in blood cells from alcoholics and controls.
Ethanol inhibited in vitro alpha-2 adrenergic receptor binding in platelets with an IC50 of 380 mM and beta adrenergic receptor binding in lymphocytes and polymorphonuclear leucocytes with IC50 values of about 1 M. The characteristics of alpha-2 receptor binding were similar in platelets from chronic alcoholics and from non-alcoholics. The densities of beta adrenergic receptors were similar in blood cells from alcoholics and controls, although there were some changes in receptor affinities. Thus, chronic alcohol consumption does not appear to have a substantial effect on adrenergic receptor binding in blood cells.
D000328:Adult; D000437:Alcoholism / Q000097:blood*; D001773:Blood Cells / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism; D006801:Humans; D007700:Kinetics; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism; D011941:Receptors, Adrenergic / Q000378:metabolism*; D015016:Yohimbine / Q000378:metabolism
D011941:Receptors, Adrenergic; D015016:Yohimbine