[Effect of sex steroids in vivo and in vitro on the binding of uric acid to plasma proteins].
Modifications on the binding of uric acid to human plasma proteins have been studied in regularly menstruating females aged 25-30 years with a normal cycle, in comparison with a group of healthy age-matched males and with a group of post-menopausal females. The binding of uric acid to plasma proteins was estimated using micropartition system Amicon. The results obtained demonstrate a significant increase of uric acid binding during ovulatory and mid-luteal phase of menstrual cycle. No modifications are shown in post-menopausal females and in healthy males. No modifications have been shown with the same experiments performed in vitro.
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism*; D005260:Female; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008593:Menopause; D008598:Menstruation; D014527:Uric Acid / Q000097:blood*
D001798:Blood Proteins; D012739:Gonadal Steroid Hormones; D014527:Uric Acid
Influenza degli steroidi sessuali in vivo ed in vitro sul legame acido urico-proteine plasmatiche.