[Participation of brain neuromediator systems in the action of parlodel on prolactin and luteinizing hormone secretion by the rat hypophysis].
The data are presented, obtained in experiments on cyclic female rats. The blood prolactin and luteinizing hormone content was examined and the dopamin level in the preoptic region and mediobasal hypothalamus was determined after a single parlodel injection to animals during the proestrous and/or estrous stage. The most pronounced effect of the drug manifested itself in a decrease in the blood prolactin content, especially in rats within the proestrous stage and, to a lesser degree, during the estrous cycle. An increased dopamin level in the mediobasal hypothalamus and the brain preoptic region of the animals during the proestrous stage was probably secondary. Marked changes in the serotonin levels were not revealed. It is suggested that the relationship between the lactotropic and luteotropic functions of the hypophysis is conditioned, to a considerable extent, by the dopaminergic system of both brain regions, involving in regulation of the gonadotropin secretion. The cyclicity disturbance was not prevented and the estrous cycle was not restored in female rats under experimental conditions of hyperestrogenemia after dopamin precursor injection.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001971:Bromocriptine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D004971:Estrus / Q000187:drug effects; D005260:Female; D007986:Luteinizing Hormone / Q000378:metabolism*; D009490:Neurosecretory Systems / Q000187:drug effects* / Q000502:physiology; D010902:Pituitary Gland / Q000187:drug effects* / Q000378:metabolism; D011247:Pregnancy; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000378:metabolism
D012701:Serotonin; D001971:Bromocriptine; D011388:Prolactin; D007986:Luteinizing Hormone; D004298:Dopamine
Uchastie neĭromediatornykh sistem mozga v deĭstvii parlodela na sekretsiiu prolaktina i liuteiniziruiushchego gormona gipofizom krys.