Ocular infection with orf virus.
Orf virus infection of the pericanthal eyelid skin and conjunctiva was diagnosed by electron microscopy. Orf is a paravaccinia virus responsible for contagious pustular dermatitis in sheep and goats. It occasionally affects humans. The patient was a farmwife who had recently handled lambs. She had a raised ulcerating lesion at the inner canthus, follicular conjunctivitis, and lymphadenopathy. Treatment with 35% idoxuridine in dimethylsulfoxide on the skin and 0.5% idoxuridine ointment on the conjunctiva led to resolution after three weeks.
D000328:Adult; D000818:Animals; D003229:Conjunctival Diseases / Q000188:drug therapy / Q000473:pathology; D004121:Dimethyl Sulfoxide / Q000627:therapeutic use; D004474:Ecthyma, Contagious / Q000188:drug therapy / Q000473:pathology*; D005141:Eyelid Diseases / Q000188:drug therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D007065:Idoxuridine / Q000627:therapeutic use; D012756:Sheep
D007065:Idoxuridine; D004121:Dimethyl Sulfoxide