Effects of pulmonary congestion on airway reactivity to histamine aerosol in dogs.
We examined the effect of acute pulmonary vascular congestion on bronchial reactivity in dogs in a standard challenge protocol. Airway responsiveness to histamine whose concentration was varied in a stepwise incremental fashion was assessed from changes in pulmonary resistance (RL) and dynamic compliance (Cdyn) in 10 anesthetized dogs. Brief acute pulmonary congestion was created by inflating a balloon placed in the left atrium to raise left atrial pressure to 20-30 cmH2O for 1 min. Pulmonary congestion did not change RL in the control condition. However, after histamine inhalation, RL was further increased by pulmonary congestion, making the two effects synergistic. This phenomenon could not be observed with vagi cut. Pulmonary congestion decreased Cdyn in all dogs regardless of histamine concentration, with or without vagotomy. We conclude that pulmonary vascular congestion makes the bronchi hyperreactive through vagal reflexes. The reduction in Cdyn caused by pulmonary congestion appears to stem mainly from the narrowing of peripheral airways by adjacent vascular engorgement.
D000336:Aerosols; D000818:Animals; D004285:Dogs; D006632:Histamine / Q000494:pharmacology*; D008170:Lung Compliance; D010827:Physiology / Q000295:instrumentation; D011652:Pulmonary Circulation; D012137:Respiratory System / Q000187:drug effects* / Q000503:physiopathology; D013990:Tidal Volume; D014628:Vagotomy; D014652:Vascular Diseases / Q000503:physiopathology*
D000336:Aerosols; D006632:Histamine