Euploidization of human hepatocytes from donors of different ages and both sexes compared with those from cases of Werner's syndrome and progeria.
Quantitative cytochemical studies of ploidy values for mono- and bi-nucleate hepatocytes from human livers of individuals from 15 weeks to 80 years of age, confirm earlier reports that the main ploidy shifts occur at 6-7 years, puberty and 21 years of age. In addition, the pattern of ploidy increase is similar to that described for other mammals. Ploidy values obtained for hepatocytes from two patients with Werner's Syndrome are in excess of those from livers of normal individuals of similar age. In contrast, ploidy values from the liver of a single case of Hutchinson-Gilford Syndrome were similar to those from children of a similar age group.
D000293:Adolescent; D000368:Aged; D000375:Aging; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008099:Liver / Q000648:ultrastructure*; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D011371:Progeria / Q000473:pathology*; D014898:Werner Syndrome / Q000473:pathology*