The effect of continuous subcutaneous insulin infusion on serum lipids.
The effect of continuous subcutaneous insulin infusion (CSII) on serum lipids was examined in 2 groups of insulin dependent diabetic patients. Twelve paired patients selected by a random procedure to be treated with CSII or conventional insulin injections had lipids measured monthly for 6 months. A more heterogenous group of 13 CSII treated patients including the 6 randomised patients had lipids measured initially and after their maximum duration of CSII (range 3 to 18 months). Significant falls were seen in HbAI, plasma glucose and triglycerides in CSII treated patients whether the 6 randomised or the group of 13 were examined. High density, lipoprotein cholesterol (HDL-C) rose significantly in both groups. In the larger group of 13, a drop in the low density lipoprotein cholesterol (LDL-C) to HDL-C ratio and LDL-C was also seen. Control patients showed no significant changes. These findings confirm but are slightly different from improvements in lipids found in other studies of long-term CSII. In addition it was demonstrated that these changes could be maintained in patients managed outside the strict rigors of a controlled study.
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007332:Insulin Infusion Systems; D008055:Lipids / Q000097:blood*; D008297:Male; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D002784:Cholesterol; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006442:Glycated Hemoglobin; D008055:Lipids; D014280:Triglycerides