Perinatal linoleate deprivation impairs learning and memory in adult rats.
Rats receiving polyunsaturated fatty acid (PUFA) deficient diets during the perinatal period showed in adult age undisturbed acquisition of a footshock motivated brightness discrimination task, but a significant impairment of retention. The same effects on retention were obtained in rats receiving the PUFA deficient diet in adulthood, when the behavioral parameters were investigated at the end of the dietary treatment.
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000254:growth & development; D004193:Discrimination Learning / Q000502:physiology; D005260:Female; D006801:Humans; D007859:Learning Disabilities / Q000209:etiology*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000172:deficiency*; D008569:Memory Disorders / Q000209:etiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011453:Prostaglandins / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012153:Retention, Psychology / Q000502:physiology; D014796:Visual Perception / Q000502:physiology
D008041:Linoleic Acids; D011453:Prostaglandins; D019787:Linoleic Acid