title: Induction of implantation by aromatase inhibitors in ovariectomized mice.
abstract: The ability of aromatase inhibitors to induce implantation in mice was tested in animals in which implantation was delayed by ovariectomy and progesterone treatment. Implantation was consistently induced by 7 mg 4-hydroxyandrostene-3,17-dione (4-OH-A), 7 X 5 mg 1,4,6-androstatriene-3,17-dione (ATD) or 15 mg 4-acetoxyandrostene-3,17-dione, an activity comparable to that of 1 mg testosterone. In intact mice treated with 2 or 10 mg 4-OH-A or ATD/day from Day 2 of pregnancy (Day 1 = vaginal plug), the number and size of implantation sites were not affected. These results may not be necessarily due to inhibitory effects of the compounds on aromatase.
mesh_terms: D000733:Androstatrienes / Q000494:pharmacology; D000735:Androstenedione / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D047072:Aromatase Inhibitors; D002369:Castration; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology; D013739:Testosterone / Q000494:pharmacology
chemical_list: D000733:Androstatrienes; D047072:Aromatase Inhibitors; C011658:androsta-1,4,6-triene-3,17-dione; D013739:Testosterone; D000735:Androstenedione; D011374:Progesterone; C022569:4-acetoxy-4-androstene-3,17-dione; D010088:Oxidoreductases; C014594:formestane