title: Binding of centchroman--a nonsteroidal antifertility agent to human plasma proteins.
abstract: Centchroman, a non-steroidal antifertility agent showed a low affinity (Kd = 13.19 X 10(-6) M) and nonsaturable binding to human plasma. Centchroman did not compete either with sex hormone binding globulin or corticosteroid binding globulin. Polyacrylamide gel electrophoresis and temperature dependent binding characteristics revealed that the protein responsible for centchroman binding to human plasma resembles albumin.
mesh_terms: D001578:Benzopyrans / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism; D002486:Centchroman / Q000097:blood*; D005260:Female; D006801:Humans; D007700:Kinetics; D012709:Serum Albumin / Q000378:metabolism; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D014156:Transcortin / Q000378:metabolism
chemical_list: D001578:Benzopyrans; D001798:Blood Proteins; D002352:Carrier Proteins; D012709:Serum Albumin; D012738:Sex Hormone-Binding Globulin; D002486:Centchroman; D014156:Transcortin