Anticonvulsant action of 2-amino-7-phosphonoheptanoic acid in the substantia nigra.
Focal injection of 2-amino-7-phosphonoheptanoic acid in the substantia nigra, pars reticulata or pars compacta, in rats produces a dose-dependent suppression of the tonic extensor seizure component in the electroshock test. Haloperidol pretreatment prevents stereotyped behaviour induced by 2-amino-7-phosphonoheptanoic acid, but does not change the effect on the electroshock test. This anticonvulsant effect of 2-amino-7-phosphonoheptanoic acid probably results from an antagonist action at a receptor site sensitive to N-methyl-D-aspartate leading to a decrease in activity in nigral efferent systems.
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives*; D000596:Amino Acids / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects / Q000503:physiopathology; D004597:Electroshock; D006220:Haloperidol / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000503:physiopathology; D007267:Injections; D008297:Male; D009118:Muscimol / Q000008:administration & dosage / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology / Q000517:prevention & control*; D013378:Substantia Nigra / Q000187:drug effects* / Q000503:physiopathology
D000596:Amino Acids; D009118:Muscimol; D015763:2-Amino-5-phosphonovalerate; D006220:Haloperidol; C031231:2-amino-7-phosphonoheptanoic acid