Labilising effect of suramin on rat kidney lysosomes in vivo.
The effect of administration of suramin on the urinary levels of some lysosomal enzymes in rats was investigated. The urinary levels of acid phosphatase and lysozyme were significantly elevated 24 h after drug administration. The high levels were sustained for 9 days after drug administration was terminated. These actions were indicative of labilization of kidney lysosomal membrane by the drug molecules, the membrane being repaired and integrity restored some days following termination of drug administration.
D000135:Acid Phosphatase / Q000652:urine*; D000818:Animals; D007425:Intracellular Membranes / Q000378:metabolism; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D009113:Muramidase / Q000652:urine*; D051381:Rats; D013498:Suramin / Q000494:pharmacology*
D013498:Suramin; D000135:Acid Phosphatase; D009113:Muramidase