Structure of the influenza C glycoprotein gene as determined from cloned DNA.
The complete nucleotide sequence of RNA segment 4 of influenza C/JHB/1/66 virus has been determined, utilizing cloned cDNA derived from the viral RNA segment. The gene is 2073 nucleotides in length, and can code for a polypeptide of 655 amino acids, which corresponds to the viral glycoprotein. The predicted polypeptide has a molecular weight of 72 063, not including oligosaccharides linked to eight predicted glycosylation sites. The influenza C glycoprotein shares structural features with hemagglutinin (HA) glycoproteins of influenza A and B viruses, including three stretches of hydrophobic amino acids believed to function as a signal sequence, a fusion function, and a membrane anchor. However, a substantial part of the protein lacks direct sequence homology to these HA glycoproteins. The results suggest a more distant evolutionary relationship between influenza C virus and influenza A and B viruses, compared to that between influenza A and B themselves.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D001483:Base Sequence; D003001:Cloning, Molecular; D004247:DNA / Q000032:analysis; D006023:Glycoproteins / Q000235:genetics*; D009975:Orthomyxoviridae / Q000235:genetics*; D012367:RNA, Viral / Q000032:analysis*; D014764:Viral Proteins / Q000235:genetics*
D000596:Amino Acids; D006023:Glycoproteins; D012367:RNA, Viral; D014764:Viral Proteins; D004247:DNA