title: The coulombic hypothesis of mitochondrial energy transduction: an attempt to quantify relationships in the energized zones.
abstract: From a consideration of (i) an assumed maximal respiration rate (ii) the ATP synthesis which can be obtained from mitochondria after respiratory inhibition and (iii) electrophoretic mobility data, the number of energized zones on the mitochondrial inner membrane has been assessed as 0.68 X 10(18)/g protein. For a single zone (representing one electron transport chain, three phosphorylating complexes and three fixed-charge cycles) in which all the cycles use molecular species doubly-charged in the energized form (b2-), the zone area will be 134 A2 and the specialized fixed charge concentration 4.5 X 10(-2) sigma/A2. The lifetime ("blink") of any energized form will be 24.4 ms, 5% of the cycle repeat time when a site 1 substrate is being oxidized.
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D004573:Electrolytes / Q000378:metabolism; D004579:Electron Transport; D004734:Energy Metabolism; D008566:Membranes / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism*; D013816:Thermodynamics
chemical_list: D004573:Electrolytes; D000255:Adenosine Triphosphate