title: A note on adult sheep vaccination with reduced dose of Brucella melitensis Rev 1.
abstract: This work describes results obtained by vaccinating pregnant ewes from a Brucella melitensis-infected flock, with 5 x 10(8) CFU (half dose) Rev 1. Only five abortions were recorded after vaccinating 600 pregnant ewes. The serological response was followed by rose bengal, complement fixation and radial immunodiffusion tests. A short-termed, low humoral immunoresponse was produced. The radial immunodiffusion test could be more useful than the other tests for differentiating infected from vaccinated sheep. It was concluded that vaccination with 5 x 10(8) CFU Rev 1 seems to have little or no effect on the normal development of pregnancy.
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D002002:Brucella / Q000276:immunology*; D002006:Brucellosis / Q000517:prevention & control / Q000662:veterinary*; D005260:Female; D007114:Immunization / Q000662:veterinary*; D011247:Pregnancy; D012756:Sheep; D012757:Sheep Diseases / Q000517:prevention & control*
chemical_list: D001428:Bacterial Vaccines