title: Experimental infection of mice by Fonsecaea pedrosoi and Wangiella dermatitidis.
abstract: After i.v. inoculation in cortisone-pretreated mice Fonsecaea pedrosoi produced a chronic infection characterized by black lesions in the skin and subcutis with sclerotic bodies resembling the tissue form of human chromomycosis in addition to lesions in the brain and other organs. Wangiella dermatitidis inoculated into unpretreated mice produced an acute, fatal cerebral infection closely resembling human phaeohyphomycosis. Abundant hyphal growth was observed in the brain tissue.
mesh_terms: D000818:Animals; D001922:Brain Abscess / Q000209:etiology; D001927:Brain Diseases / Q000382:microbiology*; D002862:Chromoblastomycosis / Q000382:microbiology; D003348:Cortisone / Q000494:pharmacology; D004195:Disease Models, Animal; D006099:Granuloma / Q000209:etiology; D008297:Male; D051379:Mice; D003904:Mitosporic Fungi / Q000254:growth & development; D009181:Mycoses / Q000382:microbiology
chemical_list: D003348:Cortisone