title: Effect of plant extracts on the in vitro interferon synthesis.
abstract: The extracts of roots and rhizomes of Angelica and Peucedanum genera, known in popular medicine for their various activities, were investigated in search of non-virus interferon inducers. It has been found that none of the extracts tested, induce interferon in human cell cultures. However, the extract from Peucedanum verticillare augmented the yield of interferon in the in vitro human fibroblast cell culture and human leukocytes suspensions when Sendai or NDV viruses were used as inducers. The increase of interferon yield was observed when the plant extract was administered at the time of interferon messenger RNA synthesis.
mesh_terms: D002478:Cells, Cultured; D006801:Humans; D007370:Interferon Type I / Q000096:biosynthesis*; D010936:Plant Extracts / Q000494:pharmacology*
chemical_list: D007370:Interferon Type I; D010936:Plant Extracts