[Statistical analysis of the elimination of chromosome-type aberrations and the fate of the aberrant cells].
The regularities of elimination of gamma-ray induced chromosome aberrations in human nonstimulated lymphocytes and the fate of aberrant cells have been studied. The cells at the first, second and third post-irradiation divisions were identified by the technique of differential staining of sister chromatids. A mathematical model has been suggested to describe the processes of formation, multiplication and death of the cells with dicentrics. This model has been shown to be in a good agreement with the experimental data. According to the model, the distribution of dicentrics among cells at the first and second mitoses follows the Poisson distribution. The analysis of the model has shown that the probability of divergence of two chromatids from one dicentric chromosome is equal 1/2, and that the acentric and monocentric types of chromosome aberrations have no influence upon cell survival in vitro. A method for empirical estimation of survival of other types of aberrations has been suggested. According to these estimates, the probabilities of transmission to the next mitosis are equal 2/3, 1 and 1/3 for paired fragments, ring chromosomes and interstitial deletions, respectively. It has been shown that approximately 1/4 of survived acentric structures can diverge to both daughter cells.
D001973:Bromodeoxyuridine / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure; D008957:Models, Genetic; D011336:Probability; D013223:Statistics as Topic
D001973:Bromodeoxyuridine
Statisticheskiĭ analiz éliminatsii aberratsiĭ khromosomnogo tipa i sud'by aberrantnykh kletok.