Evidence for thimerosal induced cytoprotection on rat stomach.
Intragastrically administered thimerosal protects against ethanol induced ulceration with an ID50 of 1.6 mg/kg body weight. In contrast, intravenously administered thimerosal exhibits an ID50 of greater than 30 mg/kg. The antiulcerogenic effect of thimerosal persists for at least 20 hours before allowing gastric ulcers to be induced by ethanol. Intragastric application of thimerosal protects against acetyl salicylic acid induced with an ID50 of 6.8 mg/kg. Stress ulceration is inhibited by thimerosal with an ID50 of 9.2 mg/kg body weight. Investigations on the structure-activity relationship show that it is the mercury moiety and not the thiosalicylic acid moiety which is responsible for the inhibition by thimerosal.
D000818:Animals; D001241:Aspirin / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity; D005035:Ethylmercury Compounds / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications; D013329:Structure-Activity Relationship; D013849:Thimerosal / Q000494:pharmacology*
D005035:Ethylmercury Compounds; D013849:Thimerosal; D000431:Ethanol; D001241:Aspirin