Comparative pharmacokinetics of [65Zn]zinc sulfate and [65Zn]zinc pantothenate injected intravenously in rabbits.
The pharmacokinetics of zinc sulfate were compared with those of a new zinc salt, pantothenate, in rabbits. Each salt was administered at a dosage of 3.3 microCi of zinc-65/kg of body weight. The measured pharmacokinetics of the two compounds responded to a two-compartment open model. The urinary elimination of the two salts was similar, as was their localization in the skin and fur, but zinc pantothenate was fixed by the liver to a lesser extent than was zinc sulfate.
D000818:Animals; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D010205:Pantothenic Acid / Q000378:metabolism*; D011817:Rabbits; D013431:Sulfates / Q000378:metabolism*; D014018:Tissue Distribution; D015032:Zinc / Q000378:metabolism*; D015037:Zinc Radioisotopes; D019287:Zinc Sulfate
D013431:Sulfates; D015037:Zinc Radioisotopes; D010205:Pantothenic Acid; D019287:Zinc Sulfate; D015032:Zinc