[Possible correction of the isoenzyme spectrum of lactate dehydrogenase in the developing rat brain in antenatal hypoxia].
In ontogenesis (within 14 and 30 days of postnatal period) in brain cortex and medulla oblongata of rats the LDH isoenzyme spectrum was altered exhibiting an increase in LDH1 and a decrease in LDH5 content. Antenatal hypoxia caused a decrease in aerobic isoenzymes in brain cortex and an increase in their content in medulla oblongata. Nootropyl (pyracetame) corrected the LDH isoenzyme spectra in brain cortex of 14 days old rats and in medulla oblongata of 30 days old animals. The correction of the isoenzyme spectra was not observed in 30 days old animals.
D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000201:enzymology* / Q000254:growth & development; D002540:Cerebral Cortex / Q000201:enzymology; D000860:Hypoxia / Q000201:enzymology*; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D008526:Medulla Oblongata / Q000201:enzymology; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats
D007527:Isoenzymes; D011760:Pyrrolidinones; D007770:L-Lactate Dehydrogenase; D010889:Piracetam
K vozmozhnosti korrektsii izofermentnogo spektra laktatdegidrogenazy razvivaiushchegosia mozga krys s antenatal'noĭ gipoksieĭ.