title: [Biological control of the brucellin INRA in sensitized guinea pigs: a guide for the statistical analysis of results].
abstract: Brucellin INRA is a new allergen used for the screening of brucellosis. It shows, by a delayed-type skin hypersensitivity reaction, the sensitization induced in animals by a brucella infection. The biological potency of each batch must be compared to that of a standard allergen. The use of guinea-pigs necessary for this quality control and the statistical analysis of the results are described and discussed. The aim of this paper is to provide the end-user with a simple and accurate method, and to alert him to the difficulties and limits of such a test.
mesh_terms: D000485:Allergens / Q000276:immunology; D000704:Analysis of Variance; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D002002:Brucella / Q000276:immunology; D002006:Brucellosis / Q000175:diagnosis / Q000662:veterinary*; D004306:Dose-Response Relationship, Immunologic; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000175:diagnosis / Q000662:veterinary*; D007428:Intradermal Tests / Q000662:veterinary; D011786:Quality Control
chemical_list: D000485:Allergens; D000942:Antigens, Bacterial; C005641:brucellin
vernacular_title: Contröle biologique de la brucelline INRA sur cobayes sensibilisés: guide pour l'analyse statistique des résultats.