[Effect of obzidan on the indices of gas exchange and the sympathetic-adrenal system in ischemic heart disease patients with different types of circulation].
The relationship between the effect of propranolol treatment on oxygen consumption during exercise and the activity of the sympathoadrenal system (SAS) and the initial hemodynamic circulatory type was established in patients with coronary heart disease (CHD). In patients with the hyper- and eukinetic circulatory types, propranolol caused an increase in the maximal oxygen consumption (MOC), pointing to the improvement of the functional possibilities of the cardiovascular system during exercise, with this improvement being more marked in patients with the hyperkinetic type. This effect of propranolol in the latter group patients was coupled with a reduction in the transmitter activity of the SAS. In patients with the hypokinetic circulatory type, propranolol did not produce any substantial change in the MOC, modifying the conditions of exercise performance toward anaerobic process without exerting any effect on the SAS.
D000311:Adrenal Glands / Q000187:drug effects*; D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy / Q000503:physiopathology; D001775:Blood Circulation / Q000187:drug effects*; D002395:Catecholamines / Q000652:urine; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D004341:Drug Evaluation; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D005082:Physical Exertion / Q000187:drug effects; D011433:Propranolol / Q000627:therapeutic use*; D011659:Pulmonary Gas Exchange / Q000187:drug effects*; D013564:Sympathetic Nervous System / Q000187:drug effects*
D002395:Catecholamines; D011433:Propranolol
Vliianie obzidana na pokazateli gazoobmena i simpatiko-adrenalovoĭ sistemy u bol'nykh ishemicheskoĭ bolezn'iu serdtsa s razlichnymi tipami krovoobrashcheniia.