Molecular cloning and chromosomal assignment of the human homolog of int-1, a mouse gene implicated in mammary tumorigenesis.
Viral mammary tumorigenesis in mice is frequently initiated by proviral activation of a highly conserved cellular gene called int-1. We have cloned the human homolog of this putative mammary oncogene and compared its structure to that of the mouse gene by heteroduplex analysis. The human int-1 gene was localized on chromosome 12 by use of somatic cell hybrids.
D000818:Animals; D001943:Breast Neoplasms / Q000235:genetics*; D002906:Chromosomes, Human, 6-12 and X; D003001:Cloning, Molecular; D006801:Humans; D008325:Mammary Neoplasms, Experimental / Q000235:genetics*; D051379:Mice; D009857:Oncogenes; D013045:Species Specificity