Pharmacological protection against hypoxia-induced effects on medium-term memory in a two-way avoidance paradigm.
Male guinea-pigs were trained in a two-way avoidance task. They were exposed for 1 min to 100% nitrogen after each of the two daily sessions on 5 consecutive days. Eight groups of 10 animals were pretreated with a single dose of either flunarizine (0.16 or 0.63 mg/kg), nimodipine (0.16 or 0.63 mg/kg), nifedipine (0.16 or 0.63 mg/kg) or verapamil (0.63 or 2.5 mg/kg) 1 h before the first daily session. Only flunarizine protected against the hypoxia-induced amnesia. The results are discussed with reference to protective effects in other paradigms and the utility of the paradigm for pharmacological research purposes.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects; D002936:Cinnarizine / Q000031:analogs & derivatives / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005444:Flunarizine; D006168:Guinea Pigs; D002534:Hypoxia, Brain / Q000188:drug therapy*; D008297:Male; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects; D009539:Nicotinic Acids / Q000494:pharmacology; D009543:Nifedipine / Q000494:pharmacology; D009553:Nimodipine; D012153:Retention, Psychology / Q000187:drug effects*; D014664:Vasodilation / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D009539:Nicotinic Acids; D002936:Cinnarizine; D009553:Nimodipine; D014700:Verapamil; D009543:Nifedipine; D005444:Flunarizine