Absence of 5 alpha-dihydrotestosterone action in the sebaceous-like uropygial gland of the male Japanese quail.
The uropygial gland of the quail, a sebaceous-like gland, has been proven to be androgen-dependent. Waxes secreted by this gland consist of fatty acids esterified by alkane-2,3-diols [12]. In castrated quails, the relative concentration of dodecane diol was enhanced after testosterone treatment; but 5 alpha-DHT could not evoke any increase in the relative concentration of dodecane diol. It is not possible from our present results to know if this lack of gland response to DHT administration is related to a high level of DHT metabolism in the gland cells or to a decreased affinity of the androgen receptor for DHT. However, because of the high similarity existing between uropygial gland of birds and mammalian sebaceous glands, these results give rise to the question of the true role of DHT in mammalian sebaceous glands.
D000818:Animals; D002369:Castration; D003370:Coturnix; D013196:Dihydrotestosterone / Q000494:pharmacology*; D008297:Male; D012627:Sebaceous Glands / Q000187:drug effects*; D013739:Testosterone / Q000097:blood
D013196:Dihydrotestosterone; D013739:Testosterone