Bimodal effects of MVE-2 on cytotoxic activity of natural killer cell and macrophage tumoricidal activities.
Maleic anhydride divinyl ether of molecular weight 15,500 (MVE-2) increased tumoricidal activity of NK cells and M phi in a dose-dependent manner with the peak response of both effector cells occurring 3 days following treatment. Both effector cell responses were sustained for over 7 days following one injection. However, repeated injections with MVE-2 led to a hyporesponsiveness of NK cells whereas M phi activity remained high. Poly ICLC, but not C. parvum, reconstituted NK cell activity in mice hyporesponsive to MVE-2. Significant antitumor response was achieved when tumor cells were inoculated at the peak time of effector cell response, indicating the in vivo role of NK and/or M phi in exerting a tumoricidal effect.
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D004306:Dose-Response Relationship, Immunologic; D007694:Killer Cells, Natural / Q000276:immunology*; D007700:Kinetics; D008223:Lymphoma / Q000276:immunology* / Q000628:therapy; D008262:Macrophage Activation / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011108:Polymers / Q000494:pharmacology*; D011425:Propionibacterium acnes / Q000276:immunology; D011713:Pyran Copolymer / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D011108:Polymers; D011713:Pyran Copolymer