title: DNA damage induced by asbestos in the presence of hydrogen peroxide.
abstract: Treatment of calf thymus DNA with various types of asbestos fibers in the presence of hydrogen peroxide under physiological conditions (pH 7.4, 37 degrees) resulted in the hydroxylation of the C-8 position of guanine residues. DNA strand scission was also detected after these treatments.
mesh_terms: D000818:Animals; D001194:Asbestos / Q000633:toxicity*; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D004247:DNA; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D006900:Hydroxylation; D013329:Structure-Activity Relationship; D013950:Thymus Gland
chemical_list: D001194:Asbestos; D004247:DNA; D006861:Hydrogen Peroxide