Effects of oral lynestrenol administration on prenatal and postnatal progeny development in rabbits.
Pregnant Belted Dutch rabbits were administered lynestrenol (17-alpha-ethynyl-oestr-4-en-17-beta-ol) orally on days 6-18 of gestation at a dose of 0.5 mg/kg/day. The dose littered on term and the surviving offspring were observed until four weeks old. Neurological disturbances characterized by behavioural abnormalities and locomotor disabilities were observed. About 40% of the offspring died within four weeks, and more than 70% of these had congenital malformations.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000284:Administration, Oral; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D005260:Female; D008234:Lynestrenol / Q000008:administration & dosage / Q000633:toxicity*; D009043:Motor Activity / Q000187:drug effects*; D011247:Pregnancy; D011817:Rabbits
D008234:Lynestrenol