On mechanism of urate kidney stone formation.
Experimental hyperuricemic kidney and urate kidney stone were made in rats, and the mechanism of urate stone formation was investigated at electron microscopic level. Continuous hyperuricosuria caused first the microcrystal, probably a stone embryo, in the distal tubule. In the surroundings of the crystal there were wandering and infiltration of numerous polymorphonuclear leucocytes which, in the distal tubule, showed phagocytosis of enlarged urate crystal and encircled the crystal. These results suggested that the polymorphonuclear leucocytes greatly contribute to an increase of urate crystal with continuous hyperuricosuria. The urate crystal in the collecting tube, expanded and flowed down, and progressed two ways; one stayed, occluded and developed to stone in the duct and the other was released from the papilla opening into the duct to be excreted.
D000818:Animals; D003460:Crystallization; D007669:Kidney Calculi / Q000473:pathology*; D008297:Male; D008855:Microscopy, Electron, Scanning; D051381:Rats; D011919:Rats, Inbred Strains; D014527:Uric Acid
D014527:Uric Acid