title: Pharmacokinetics of buflomedil after intravenous administration in patients with chronic renal failure.
abstract: The pharmacokinetics of single intravenous doses of buflomedil were studied in nine patients with chronic renal failure. The mean buflomedil half-life was 5.38 h (range 1.78-11.8 h); the mean buflomedil total clearance was 11.8 l/h (range 2.67-37.2 l/h). Comparisons of buflomedil kinetic parameters between the uraemic patients and healthy subjects revealed significant decreases in the renal elimination percentage u, the renal clearance Clr; significant increase in elimination half-life from the central compartment and no significant differences in the other parameters. Chronic renal failure is associated with a significant alteration in buflomedil elimination. This study suggests to reduce the usual dosage to half its value in the renal disease.
mesh_terms: D000328:Adult; D000368:Aged; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007676:Kidney Failure, Chronic / Q000097:blood / Q000378:metabolism* / Q000652:urine; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011485:Protein Binding / Q000187:drug effects; D011759:Pyrrolidines / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000652:urine
chemical_list: D011759:Pyrrolidines; D003404:Creatinine; C010651:buflomedil