title: Analysis of tablets containing aspirin, acetaminophen, and ascorbic acid by high-performance liquid chromatography.
abstract: The high-performance liquid chromatographic method described enables the quantitation of the components and the main impurities of tablets containing aspirin, acetaminophen, and ascorbic acid. A C8 reverse-phase column was used; the mobile phase was methanol-0.2 M phosphate buffer (pH 3.5)-water (20:10:70). Results obtained for a brand of effervescent tablets, normally aged for 5 years and stressed at 37 degrees C, 50 degrees C, or in 79% relative humidity at room temperature, are reported. Salicylic acid was the main product of decomposition. Diacetyl-p-aminophenol was observed to be formed by transacetylation.
mesh_terms: D000082:Acetaminophen / Q000031:analogs & derivatives / Q000032:analysis*; D001205:Ascorbic Acid / Q000032:analysis*; D001241:Aspirin / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D006813:Humidity; D006863:Hydrogen-Ion Concentration; D012459:Salicylates / Q000032:analysis; D020156:Salicylic Acid; D013607:Tablets; D013696:Temperature; D013997:Time Factors
chemical_list: D012459:Salicylates; D013607:Tablets; D000082:Acetaminophen; C029014:diacetamate; D020156:Salicylic Acid; D001205:Ascorbic Acid; D001241:Aspirin