Comparison of the emotional effects of a beta-adrenergic blocking agent and a tranquilizer under different situational conditions. I. Anxiety-arousing situations.
This study investigated the emotional effects of the beta-adrenergic blocking agent oxprenolol (40 mg, p.o.) and the tranquilizing agent diazepam (5 mg, p.o.) in healthy subjects under three situational conditions: an emotionally neutral control situation and two situations designed to arouse different levels of anxiety. Both oxprenolol and diazepam induced positive emotional changes only in the more strongly anxiety-arousing situation. Significant differences between oxprenolol and diazepam in inducing emotional stabilization were not demonstrable.
D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000209:etiology / Q000517:prevention & control*; D001143:Arousal / Q000187:drug effects; D003975:Diazepam / Q000494:pharmacology / Q000627:therapeutic use*; D004644:Emotions / Q000187:drug effects; D006801:Humans; D008297:Male; D009622:Noise / Q000009:adverse effects; D010096:Oxprenolol / Q000494:pharmacology / Q000627:therapeutic use*
D010096:Oxprenolol; D003975:Diazepam