Absorption, distribution, and excretion of 8-methoxypsoralen in HRA/Skh mice.
The tissue distribution and excretion of [3H]8-methoxypsoralen (8-MOP), a well-accepted therapeutic agent for the treatment of psoriasis, was studied in hairless HRA/Skh female mice. Mice were given single oral doses of 6 mg of [3H]8-MOP or 5-[14C]8-MOP/kg in corn oil. Radiochemical analyses of tissues and excreta were accomplished by liquid scintillation counting. The 8-MOP appeared to be rapidly absorbed through the gastrointestinal tract, where the tritium levels were highest, followed by skin, blood, and liver; levels were lowest in fat (adipose tissue). In female HRA/Skh mice which had not been irradiated with UVA (320-400 nm), 84% of the carbon-14 and 58% of the tritium were recovered in the urine and feces within 24 hours of oral administration of 5-[14C]8-MOP or [3H]8-MOP, respectively. Animals that were exposed to UVA and received [3H]8-MOP excreted approximately 12% less tritium in the urine and feces compared with the animals which received no UVA.
D000042:Absorption; D000818:Animals; D002250:Carbon Radioisotopes; D005260:Female; D008730:Methoxsalen / Q000378:metabolism*; D051379:Mice; D008812:Mice, Hairless; D008817:Mice, Mutant Strains; D011701:PUVA Therapy; D014018:Tissue Distribution; D014316:Tritium
D002250:Carbon Radioisotopes; D014316:Tritium; D008730:Methoxsalen