title: Informativeness in stimulus-response modelling.
abstract: The concept of informativeness is introduced in the context of A.J. Clark's pioneering "concentration-action" studies, in relation to the stimulus-response function of the accepted theory of agonist/receptor reactions and their observable consequences. The dominance of so-called "null-methods" in the existing literature is noted and contrasted with an informativeness analysis in which the unknown but estimable stimulus-response function plays an explicit rôle. Some statistical advantages of the latter approach are emphasised.
mesh_terms: D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D008954:Models, Biological; D010600:Pharmacology; D011955:Receptors, Drug; D013223:Statistics as Topic
chemical_list: D011955:Receptors, Drug