Autoradiography of nadolol and propranolol in the rat.
Whole-body autoradiography of rats dosed with [14C]propranolol or [14C]nadolol have confirmed physicochemical predictions that nadolol, in contrast to propranolol, penetrates the CNS only to a slight extent, if at all. Differences between the CNS penetration of different beta-blockers have implications for the mechanism of the hypotensive action and the prevalence of side-effects associated with disturbance of the CNS.
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism; D002490:Central Nervous System / Q000378:metabolism*; D005260:Female; D008297:Male; D009248:Nadolol; D011412:Propanolamines / Q000378:metabolism*; D011433:Propranolol / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D011412:Propanolamines; D009248:Nadolol; D011433:Propranolol