[Mechanism of action of dialkylaminoethylthiol derivatives of pyrimidine and quinazoline].
A study was made of acute toxicity and radioprotective efficiency of some heterocyclic isothiuronium analogues and their ability to change the oxygen uptake by the organism. The rate of hydrolysis of the preparations in vitro was determined. A correlation was found between the above-mentioned indices. On the basis of the data obtained it was concluded that aminothiol, formed as the result of enzymic digestion in the organism, was responsible for the radioprotective effect of the compounds under study since it reduced the oxygen uptake by the organism.
D000818:Animals; D005021:Ethylamines / Q000627:therapeutic use; D051379:Mice; D010101:Oxygen Consumption / Q000187:drug effects; D011743:Pyrimidines / Q000627:therapeutic use*; D011799:Quinazolines / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D013440:Sulfides / Q000627:therapeutic use
D005021:Ethylamines; D011743:Pyrimidines; D011799:Quinazolines; D011837:Radiation-Protective Agents; D013440:Sulfides
K voprosu o mekhanizme deĭstviia dialkilaminoétiltiol'nykh proizvodnykh pirimidina i khinazolina.