Electrostatic effects in acylation of hemoglobin by aspirins.
Carboxylate substituents added to the salicylate ring increase the effectiveness of a variety of aspirins and diaspirins in acylating hemoglobin. Even more effective are a series of monoesters of dicarboxylate derivatives. Bis(5-carbomethoxysalicyl)fumarate and -succinate at 5 mM concentrations modify approximately 100% of the hemoglobin in solution and should alter the aggregation behavior of sickle hemoglobin.
D000215:Acylation; D001241:Aspirin / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D004560:Electricity; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D012459:Salicylates / Q000494:pharmacology
D006454:Hemoglobins; D012459:Salicylates; D001241:Aspirin