title: Calcium-dependent potentials in mammalian red nucleus neurons in vitro.
abstract: Intracellular recordings were made from red nucleus (RN) neurons in guinea-pig slice preparations. The slow afterhyperpolarization (AHP) following an action potential was reversibly abolished by Co2+ or Mn2+. Its amplitude was dependent on the extracellular K+ concentration. When tetraethylammonium was added to the perfusing solution, a tetrodotoxin-resistant regenerative depolarization was evoked which was blocked by Co2+ or Mn2+. There results suggest that the slow AHP is produced by an increase in Ca2+-dependent K+ conductance and that RN neurons have a voltage-dependent Ca2+ conductance.
mesh_terms: D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000502:physiology*; D003035:Cobalt / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008345:Manganese / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D012012:Red Nucleus / Q000502:physiology*; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology
chemical_list: D013757:Tetraethylammonium Compounds; D003035:Cobalt; D008345:Manganese; D013779:Tetrodotoxin; D019789:Tetraethylammonium; D011188:Potassium; D002118:Calcium