title: [Radiotherapy of cervix cancer in an advanced stage].
abstract: Fifty nine stage II-distal (i.e. with involvement of medium third of parametrium and/or vagina), 220 stage III and 5 stage IV cervical carcinomas were treated with radiotherapy alone (combination of intracavitary radium therapy and megavoltage external irradiation on the pelvis) in the years 1971-79. The 5-year relapse free survival by actuarial method was 52.0% for stage II-distal and 40.6% for stage III, while all stage IV patients relapsed within the third year from the start of the treatment. Failures were pelvic recurrence in 98/227 patients with follow-up greater than or equal to 1 year (43.2%), distant metastases in 15 (6.7%), pelvic plus distant relapse in 10 (4.4%) and 2nd tumor in 2 (0.9%). In stage III patients the renal exclusion and positivity at lymphography were the major adverse prognostic factors and 5-year relapse free survival was respectively 28.5% and 19.6%. Improvement of the results can probably derive from a combined therapeutic approach with chemotherapy and radiotherapy in a sequential scheme.
mesh_terms: D000328:Adult; D000368:Aged; D001918:Brachytherapy; D003125:Colostomy; D005260:Female; D006801:Humans; D008796:Metrorrhagia / Q000209:etiology; D008875:Middle Aged; D009367:Neoplasm Staging; D011349:Proctitis / Q000209:etiology / Q000601:surgery; D011832:Radiation Injuries / Q000401:mortality; D011867:Radioisotope Teletherapy; D013923:Thromboembolism / Q000209:etiology; D002583:Uterine Cervical Neoplasms / Q000401:mortality / Q000532:radiotherapy*
vernacular_title: Radioterapia del carcinoma cervicale in stadio avanzato.