Studies on the biosynthesis of terrecyclic acid A, an antitumor antibiotic from Aspergillus terreus.
The biosynthesis of terrecyclic acid A was investigated using 13C-labeled acetates and mevalonate. 13C NMR spectral analysis of isolated labeled terrecyclic acid demonstrated that the structure is assembled via an isoprene pathway.
D000085:Acetates / Q000378:metabolism; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D001230:Aspergillus / Q000378:metabolism*; D002247:Carbon Isotopes; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D008798:Mevalonic Acid / Q000378:metabolism; D012717:Sesquiterpenes / Q000096:biosynthesis
D000085:Acetates; D000903:Antibiotics, Antineoplastic; D002247:Carbon Isotopes; D012717:Sesquiterpenes; C036622:terrecyclic acid A; D008798:Mevalonic Acid