Pharmacokinetics of twelve anticonvulsant drugs in the rat.
The pharmacokinetic data for 12 anticonvulsant drugs was evaluated after administration to laboratory rats. In all cases the half-life and elimination rate constants were significantly different from clinically-determinant values which suggests that pharmacokinetic parameters should be treated as species specific.
D000818:Animals; D000927:Anticonvulsants / Q000097:blood / Q000378:metabolism*; D002257:Carbonic Anhydrase Inhibitors / Q000378:metabolism; D002855:Chromatography, Thin Layer; D005260:Female; D006207:Half-Life; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013056:Spectrophotometry, Ultraviolet
D000927:Anticonvulsants; D002257:Carbonic Anhydrase Inhibitors