title: A new protein quality evaluation index based on growth responses of rats.
abstract: The protein efficiency ratio (PER) is the official method for protein quality evaluation in the United States and Canada. Two other widely used indices of evaluation are the slope ratio and net protein ratio (NPR) methods. Each of these methods has problems associated with its calculation and interpretation. In this paper, a new index, actual protein utilization ( APU ) is discussed, and its relationship to the other indices is examined. Each of the indices is given a theoretical basis by relating it to the four parameter mathematical model for physiological responses. To compare the indices, growth bioassays were carried out using male rats (40, 60, 115 g) consuming three different proteins (casein, lactalbumin and soy) and an amino acid mixture (Rogers and Harper). Dose-response curves were generated for each diet, and the indices PER, NPR, Slope and APU were calculated. APU was shown to have certain characteristics that make it superior to the other methods of protein quality evaluation, i.e., it closely approximates the growth response curve and it incorporates a term for the protein intake required for maintenance.
mesh_terms: D000596:Amino Acids / Q000008:administration & dosage; D000818:Animals; D001681:Biological Assay; D001835:Body Weight / Q000187:drug effects; D002364:Caseins / Q000008:administration & dosage; D004044:Dietary Proteins / Q000008:administration & dosage / Q000592:standards*; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects; D006128:Growth / Q000187:drug effects*; D007768:Lactalbumin / Q000008:administration & dosage; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013025:Glycine max
chemical_list: D000596:Amino Acids; D002364:Caseins; D004044:Dietary Proteins; D007768:Lactalbumin