[Free and bound hydroxyproline in patients with diabetes mellitus].
Collagen metabolism was studied in 120 male patients with diabetes mellitus of different standing and severity. Collagen metabolism was assessed on the basis of free and peptide-bound blood hydroxyproline (FH and PBH). Collagen distruction prevailed over its biosynthesis in development and progress of diabetic microangiopathies, that resulted in the increased FH/PBH coefficient. Prolonged multimodality therapy of diabetes vascular complications led to a decrease in the FH level and simultaneous growth of PBH concentrations in the blood. The FH/PBH coefficient is an informative test for monitoring the vascular status in diabetes mellitus; this coefficient may be an indicator of the efficacy of treatment of diabetic microangiopathies.
D000293:Adolescent; D000328:Adult; D002196:Capillaries / Q000378:metabolism; D003094:Collagen / Q000378:metabolism*; D003228:Conjunctiva / Q000098:blood supply; D003922:Diabetes Mellitus, Type 1 / Q000378:metabolism*; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D003925:Diabetic Angiopathies / Q000209:etiology*; D006801:Humans; D006909:Hydroxyproline / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000378:metabolism; D011485:Protein Binding
D010455:Peptides; D003094:Collagen; D006909:Hydroxyproline
Svobodnyĭ i sviazannyĭ oksiprolin u bol'nykh sakharnym diabetom.