title: Tissue reaction to a failed Bion hip prosthesis in a dog.
abstract: The tissue reaction in a dog to a failed constrained total hip replacement system with a Bion elastomer component was evaluated. The device consisted of Ti-6A1-4V alloy acetabular and femoral components connected with a Bion component. At necropsy the Bion component was found to have fractured. The tissue surrounding the Bion was granulomatous with numerous blackened regions. Histologically a severe chronic inflammatory response was present in the surrounding tissue with numerous giant cells and Bion laden macrophages.
mesh_terms: D000466:Alkadienes / Q000633:toxicity*; D000818:Animals; D001672:Biocompatible Materials; D004285:Dogs; D006622:Hip Prosthesis / Q000009:adverse effects*; D007249:Inflammation / Q000209:etiology* / Q000473:pathology; D011108:Polymers / Q000633:toxicity*
chemical_list: D000466:Alkadienes; D001672:Biocompatible Materials; D011108:Polymers; C045121:Bion