Attenuation of exercise-induced R wave increase after diltiazem in effort angina pectoris.
Body surface mapping was used to study the effects of diltiazem on exercise-induced QRS amplitude changes in 7 patients with stable effort angina pectoris. Body surface areas showing R or S amplitude changes (greater than 0.2 mV) after treadmill exercise were calculated. After the administration of 90 mg of diltiazem, the R increased area was significantly smaller than that without diltiazem (p less than 0.02), although the same workload was performed. It was suggested that diltiazem diminished the exercise-induced myocardial ischemia and this improvement of ischemia resulted in the reduction of the R increased area after exercise.
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000503:physiopathology*; D001552:Benzazepines / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000175:diagnosis; D004110:Diltiazem / Q000494:pharmacology*; D004562:Electrocardiography; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D012044:Regression Analysis
D001552:Benzazepines; D004110:Diltiazem