[The hyperglycemic effect of N-methylglucamine antimonate (glucantime)].
We applied meglumine antimonate (Glucantime) to 10 albino mice in a dose of 15-30 mg/kg for first three days and then 60 mg/kg for twelve days intramuscularly, and double dose to another 10 mice. No drug was administered to 9 mice which were control group. On 16th day, there were hyperglycemia, parenchymal degeneration and inflammation in liver which were more marked in double dose group. The monitoring of blood glucose of the patients with kala-azar receiving Glucantime, was suggested.
D000818:Animals; D000965:Antimony / Q000008:administration & dosage / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis; D056486:Chemical and Drug Induced Liver Injury / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D006943:Hyperglycemia / Q000139:chemically induced*; D008536:Meglumine; D000077485:Meglumine Antimoniate; D051379:Mice; D009942:Organometallic Compounds
D001786:Blood Glucose; D009942:Organometallic Compounds; D008536:Meglumine; D000077485:Meglumine Antimoniate; D000965:Antimony
N-methylglucamine antimoniate (Glucantime)'in hiperglisemik etkisi.