[Determination of systolic time intervals in healthy and in adriamycin-treated children].
The systolic time intervals have been measured in 212 normal children, aged 3 to 16 years, and in 30 children with malignant tumours, who were treated with Adriamycin. The normal values of STI in children were calculated and evaluated. Nomogramms for Left Ventricular Ejection Time (LVET) and Pre-ejection Period (PEP) are presented to permit rapid estimation of predicted normal values in children. The evaluation of 5 consecutive heart cycles is enough for measuring STI. Statistically no significant differences were found not only between STI in girls and boys but also between STI-values measuring in the morning, at noon or in the afternoon. Adriamycin-cardiomyopathy can be detected early and reliable through the estimation of the STI.
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D004317:Doxorubicin / Q000009:adverse effects / Q000494:pharmacology*; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000502:physiology*; D006331:Heart Diseases / Q000139:chemically induced* / Q000175:diagnosis; D006338:Heart Neoplasms / Q000188:drug therapy; D006801:Humans; D008297:Male; D009200:Myocardial Contraction; D010701:Phonocardiography; D011674:Pulse; D012737:Sex Factors; D013599:Systole
D004317:Doxorubicin
Die Bestimmung der systolischen Zeitintervalle bei herzgesunden und mit Adriamycin behandelten Kindern.