title: The effect of incorporation of indomethacin with polyethylene glycol 6000 in a solid dispersion on its in vivo properties in the rat.
abstract: Preparations of indomethacin and indomethacin in combination with PEG 6000 were administered in solid form by the oral route to male rats. No significant differences in anti-oedema activity were observed between the different preparations of indomethacin, but high blood levels of drug were observed following dosing with indomethacin, in a PEG 6000 melt. Rapid dispersion formulations of indomethacin were also found to be gastro-toxic.
mesh_terms: D000818:Animals; D002351:Carrageenan; D004487:Edema / Q000209:etiology / Q000517:prevention & control; D005753:Gastric Mucosa / Q000187:drug effects; D007213:Indomethacin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D013535:Suspensions
chemical_list: D013535:Suspensions; D011092:Polyethylene Glycols; D002351:Carrageenan; D007213:Indomethacin