The role of afferents from the parafascicular-centromedian complex in the excitatory striatal neuronal response to dexamphetamine in freely moving animals.
The striatal neuronal response to dexamphetamine, 2.5 mg/kg, was studied in normal freely moving animals and in freely moving animals with unilateral lesions of the parafascicular-centromedian complex. Whereas dexamphetamine produced predominantly excitation of striatal neurons in control animals, the predominant response in lesioned animals was inhibition. In lesioned animals dexamphetamine-induced behavioral activation was unchanged. It is concluded that the PF-CM complex plays an important role in the striatal neuronal response to dexamphetamine in freely moving animals and may be one of the neural substrates conveying sensory feedback from drug-induced behavior to the striatum.
D000818:Animals; D001931:Brain Mapping; D003342:Corpus Striatum / Q000187:drug effects* / Q000502:physiology; D003913:Dextroamphetamine / Q000494:pharmacology*; D005246:Feedback; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D051381:Rats; D013787:Thalamic Nuclei / Q000502:physiology*
D003913:Dextroamphetamine