Catecholamine toxicity: a proposal for the molecular pathogenesis of manganese neurotoxicity and Parkinson's disease.
An hypothesis is presented which attempts to relate the pathogenesis of both manganese neurotoxicity and Parkinson's disease to cytotoxicity from products of catecholamine oxidation. These include the products resulting from the partial reduction of oxygen (superoxide anion, hydroxyl radical, and hydrogen peroxide) and the semiquinones and ortho quinones produced during autoxidation or oxidation of catecholamines initiated by trivalent manganese.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D002395:Catecholamines / Q000378:metabolism* / Q000633:toxicity; D002648:Child; D004257:DNA Polymerase II / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D020149:Manganese Poisoning; D008543:Melanins / Q000378:metabolism; D008875:Middle Aged; D009422:Nervous System Diseases / Q000139:chemically induced*; D009447:Neuroblastoma / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology; D010084:Oxidation-Reduction; D010300:Parkinson Disease / Q000209:etiology* / Q000503:physiopathology; D011809:Quinones / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism; D013936:Thymidine / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism
D002395:Catecholamines; D008543:Melanins; D011809:Quinones; D013438:Sulfhydryl Compounds; C014121:neuromelanin; D004257:DNA Polymerase II; D013936:Thymidine; D009638:Norepinephrine