Role of prostaglandins during reversal of one-kidney, one-clip hypertension in the rat.
Unclipping the one-kidney, one-clip rat returned blood pressure to normotensive levels within 24 h and was associated with a substantial increase in urinary PGE2 and 6-keto PGF1 alpha excretion. Prior treatment with indomethacin (6.0 mg/kg) markedly reduced urinary prostaglandins after clip removal and attenuated the fall in blood pressure. Aspirin (100 mg/kg) treatment, which reduced 6-keto PGF1 alpha to a lesser degree without altering PGE2 excretion, had no significant effect on the blood pressure fall. It is suggested that in the one-kidney, one-clip rat prostaglandins are released as the result of exposing the unclipped kidney to elevated arterial pressure, and that these contribute to the subsequent fall in blood pressure.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D006978:Hypertension, Renovascular / Q000503:physiopathology*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009392:Nephrectomy; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D011453:Prostaglandins; D001241:Aspirin; D007213:Indomethacin