title: [The course of pain in patients with confirmed duodenal ulcer under therapy with cimetidine].
abstract: In an open multicenter trial 1047 patients with endoscopically or X-ray verified duodenal ulcer were treated with 400 mg Cimetidin (Tagamet) b.i.d. The analysis of subjective pain records demonstrates 69% of the patients to suffer from severe pain before start of treatment while 3% were pain-free. Two days after start of treatment a statistically significant reduction (p less than 0.01) of intensity of pain has been proven. Five days after onset of treatment 30% of the patients are pain-free, 33% show minor impairment of well-being, 25% report moderate pain and 12% show clinically relevant pain.
mesh_terms: D000328:Adult; D002927:Cimetidine / Q000627:therapeutic use*; D004381:Duodenal Ulcer / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors
chemical_list: D002927:Cimetidine
vernacular_title: Schmerzverlauf bei Patienten mit gesichertem Ulcus duodeni unter Therapie mit Cimetidin.