Synthesis of 2-carboxy-11 beta, 17 beta-dihydroxy-17-methyl-1, 4-androstadien-3-one and related compounds.
A series of 2-carboxy-1, 4-androstadien-3-one derivatives and their alkyl esters, were prepared by high-yield syntheses. The compounds were structurally identified by physical methods. All these steroids are characterized by a marked antiglucocorticoid activity that proved long-acting in the case of the ester derivatives. 2-Carboxy-11 beta, 17 beta-dihydroxy-17-methyl-1, 4-androstadien-3-one or roxibolone, and its n-decylester or decylroxibolone, are the most promising derivatives in consideration of their pharmacological properties.
D000730:Androstadienes / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009904:Optical Rotation; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship; D045165:Testosterone Congeners / Q000138:chemical synthesis*
D000730:Androstadienes; D007202:Indicators and Reagents; D045165:Testosterone Congeners; C044300:roxibolone