Inhibitory actions of enprofylline and aminophylline on extravasation of plasma proteins induced by various agents in the rat skin.
Increased plasma protein leakage induced by i.d. injections of histamine, 5-hydroxytryptamine, bradykinin, prostaglandin E2 and ionophore A23187 in the rat skin was inhibited non-specifically by enprofylline and aminophylline in a dose related manner. Depending on the agonist used, on a weight basis enprofylline was 2.9-6.6 times more potent than aminophylline when both were given i.p. and 1.4-2.2 times more active when administered orally. Inhibitory actions of enprofylline and aminophylline were unaffected by pretreatment of animals with phentolamine and propranolol, but reduced in adrenalectomized animals.
D000628:Aminophylline / Q000494:pharmacology*; D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D001993:Bronchodilator Agents / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects*; D002395:Catecholamines / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000378:metabolism; D014970:Xanthines / Q000494:pharmacology*
D001798:Blood Proteins; D001993:Bronchodilator Agents; D002395:Catecholamines; D014970:Xanthines; D000628:Aminophylline; C034347:enprofylline