[Alkyl-6-benzoxazolinones. A chemical and pharmacodynamic study].
A series of 6-alkylbenzoxazolinones was synthesized by reduction of corresponding acyl derivatives. Two reduction processes were used, Clemmensen reduction and triethylsilane-trifluoroacetic acid reduction, but only the latter represents a general procedure for synthesis of alkyl derivatives. Pharmacological study shows that reduction of the carbonyl group is accompanied by a decrease of analgesic activity with appearance of a psycholeptic profile.
D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D007928:Lethal Dose 50; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010080:Oxazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000700:Analgesics; D010080:Oxazoles
Alkyl-6-benzoxazolinones. Etude chimique et pharmacodynamique.