[Evaluation of pressure and mechanical effects on the aggregation of human platelets induced by adenosine diphosphate in a system simulating a dialysis circuit].
Blood samples in sodium citrate 3.8% (ratio 1:10) of 15 healthy people were subjected to the pressure of 0, 50, 150 mm Hg respectively in a circuit operated by a peristaltic pump as during dialysis. The platelet aggregation induced by adenosine diphosphate (ADP) was determined in all cases. We found a significant reduction of the maximum percent aggregation of the samples exposed to the pressure of 150 mm Hg. We then suppose that a positive correlation exists between high pressure in the dialytic circuit and platelet damage.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D005260:Female; D006801:Humans; D007688:Kidneys, Artificial; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011312:Pressure; D006435:Renal Dialysis
D000244:Adenosine Diphosphate
Valutazione delle azioni pressorie e meccaniche sull'aggregazione delle piastrine umane indotta con adenosina difosfato (ADP) in un sistema simulante il circuito di dialisi.