In vitro study of ticlopidine, as a model of antisickling action of platelet antiaggregant.
The in vitro antisickling effect of ticlopidine may be explained by the action of the drug on the membrane. The drug molecule increases slightly the volume of the cell, decreases the mean intra-erythrocytic hemoglobin concentration and therefore affects the delay time for hemoglobin S polymerization.
D000925:Anticoagulants / Q000494:pharmacology*; D000986:Antisickling Agents / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects* / Q000378:metabolism; D006451:Hemoglobin, Sickle / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D013876:Thiophenes / Q000378:metabolism / Q000494:pharmacology*; D013988:Ticlopidine
D000925:Anticoagulants; D000986:Antisickling Agents; D006451:Hemoglobin, Sickle; D013876:Thiophenes; D013988:Ticlopidine