Enhanced regional uptake of 2-deoxy-D-[14C]glucose in focal herpes simplex type 1 encephalitis: autoradiographic study in the rat.
We used the 2-deoxy-D-[14C]glucose (14C-DG) quantitative autoradiographic method to assess regional glucose metabolism in rats with focal herpes simplex virus type 1 (HSV-1) encephalitis. High 14C-DG uptake was detected in infected brain structures of both immunocompetent and immunosuppressed animals, likely as a result of increased glucose utilization by infected glia and neurons. Inflammatory infiltrates did not show augmented 14C-DG tissue uptake, and indeed regional isotope uptake declined in the later stages of infection as viral replication waned and necrosis developed. 14C-DG uptake was also depressed in uninfected brain regions that received afferents from the infected visual pathway.
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism; D004660:Encephalitis / Q000378:metabolism*; D005260:Female; D005829:Geniculate Bodies / Q000378:metabolism; D006561:Herpes Simplex / Q000378:metabolism*; D009900:Optic Nerve / Q000378:metabolism; D051381:Rats; D014795:Visual Pathways / Q000378:metabolism
D003847:Deoxyglucose