An efficient synthesis of 3 alpha-hydroxy-5 alpha-pregna-9(11),16-diene-20-one.
3 alpha-Hydroxy-5 alpha-pregna-9(11),16-diene-20-one (6) was synthesized for the first time from the commercially available 16,17 alpha-epoxy-3 beta-hydroxy-5-pregnen-20-one(1) in several steps. The key step involves a remote chlorination reaction utilizing m-iodobenzoate group as a free-radical guide.
D055598:Chemical Phenomena; D002621:Chemistry; D011245:Pregnadienes / Q000138:chemical synthesis*
D011245:Pregnadienes; C045017:3 alpha-hydroxy-5 alpha-pregna-9(11),16-diene-20-one