Identical specificity of lupus antibodies and antibodies elicited in rabbits against Sm and RNP antigens.
Rabbits immunized with purified Sm and RNP small nuclear ribonucleoproteins (snRNPs) produced precipitating and hemagglutinating antibodies against these antigens. These antibodies had immunological specificity identical to the naturally occurring SLE anti-Sm/RNP antibodies as demonstrated by immunoprecipitation results and studies involving the characterization of immunoaffinity purified antigens isolated from the rabbit immune and SLE anti-Sm/RNP IgG affinity columns.
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D000918:Antibody Specificity; D000941:Antigens / Q000276:immunology*; D001324:Autoantigens; D006386:Hemagglutination Tests; D008177:Lupus Vulgaris / Q000276:immunology*; D011233:Precipitin Tests; D011817:Rabbits / Q000276:immunology; D017411:Ribonucleoproteins, Small Nuclear; D055517:snRNP Core Proteins
D000906:Antibodies; D000941:Antigens; D001324:Autoantigens; D017411:Ribonucleoproteins, Small Nuclear; D055517:snRNP Core Proteins