title: Serum biochemical changes in calves with Johne's disease.
abstract: Calves clinically affected with experimentally induced Johne's disease exhibited elevation of caeruloplasmin oxidase activity, and marked depression of alpha-mannosidase activity during the period when clinical signs of the disease were most prominent. Changes in serum copper levels and alkaline phosphatase activity were closely correlated with the elevation of caeruloplasmin oxidase activity, and depression of alpha-mannosidase activity. The pattern of these changes was similar to nutritional and metabolic changes described previously in acute infectious conditions in man and animals.
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood*; D002570:Ceruloplasmin / Q000097:blood; D003300:Copper / Q000097:blood; D008361:Mannosidases / Q000097:blood; D010283:Paratuberculosis / Q000097:blood*; D015032:Zinc / Q000097:blood; D043323:alpha-Mannosidase
chemical_list: D003300:Copper; D002570:Ceruloplasmin; D000469:Alkaline Phosphatase; D008361:Mannosidases; D043323:alpha-Mannosidase; D015032:Zinc