Difference of the inhibitory action of verapamil on the positive inotropic effect of Ca2+ between spontaneously hypertensive and normotensive rat myocardium.
Verapamil, a calcium entry blocker, had a greater inhibitory effect on the positive inotropic effect of excess Ca2+ in SHR than in NWR, suggesting that the cardiac responsiveness to verapamil was enhanced in SHR.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006325:Heart Atria / Q000503:physiopathology; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D010210:Papillary Muscles / Q000503:physiopathology; D051381:Rats; D011918:Rats, Inbred SHR; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil; D002118:Calcium