Single cell origin of radiation-induced thymic lymphoma in mice with cellular mosaicism.
The clonal origin of radiation-induced thymic lymphoma was studied in mice with cellular mosaicism for phosphoglycerate kinase (PGK). Repeated whole-body X-irradiations (4 doses, 1.7 Gy each) with intervals of 7 days resulted in development of thymic lymphomas in the mosaic mice. PGK from all lymphomas gave only a single spot on electrophoresis. The results demonstrate the single cell origin of the thymic lymphoma.
D000818:Animals; D005260:Female; D008223:Lymphoma / Q000201:enzymology / Q000209:etiology / Q000473:pathology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009030:Mosaicism; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D014411:Neoplastic Stem Cells; D010735:Phosphoglycerate Kinase / Q000032:analysis; D013953:Thymus Neoplasms / Q000201:enzymology / Q000209:etiology / Q000473:pathology*
D010735:Phosphoglycerate Kinase