[Pharmacological studies on drug dependence. (III): Intravenous self-administration of some CNS-affecting drugs and a new sleep-inducer, 1H-1, 2, 4-triazolyl benzophenone derivative (450191-S), in rats].
The present study examined comparative self-administration of some typical CNS-affecting drugs with a new sleep-inducer, 450191-S, in rats, Most animals self-administered both methamphetamine and cocaine in an extremely stable and invariable fashion with cycles of alternating responding and non-responding periods during the day and at night. Response frequency increased in proportion to a fixed-ratio value. An initial increase in response rate followed by cessation of the responding was observed during extinction. Sixty-five percent of the rats tested self-administered morphine in a relatively variable and less stable fashion. Total daily morphine intake was directly related to the unit dose. Eighty-three percent of the rats self-administered pentazocine. Fifty and sixty-four percent of the rats maintained self-administration of phenobarbital and diazepam, respectively, with higher intake at night than during the day. Responding persisted at a low rate for several days during extinction. Abrupt withdrawal of 450191-S caused the same slight weight loss and moderate decrease in food intake as those seen with diazepam and nitrazepam, and cross-physical dependence between 450191-S and diazepam was found. Self-administration of 450191-S at 0.5-2.5 mg/kg/infusion was observed with 2 out of 11 rats, which was much less than that found with diazepam. These results suggest that 450191-S possesses little, if any, drug dependence liability of the tranquilizer type.
D000818:Animals; D002491:Central Nervous System Agents; D003042:Cocaine; D003975:Diazepam; D006801:Humans; D006993:Hypnotics and Sedatives; D007275:Injections, Intravenous; D008297:Male; D008694:Methamphetamine; D009021:Morphine Dependence; D010423:Pentazocine; D010634:Phenobarbital; D051381:Rats; D011919:Rats, Inbred Strains; D012646:Self Administration; D019966:Substance-Related Disorders; D014230:Triazoles / Q000494:pharmacology*
D002491:Central Nervous System Agents; D006993:Hypnotics and Sedatives; D014230:Triazoles; D008694:Methamphetamine; C041075:rilmazafone; D003042:Cocaine; D003975:Diazepam; D010423:Pentazocine; D010634:Phenobarbital