Comparison of human and siamang ABH and MN blood groups using monoclonal antibodies.
Comparison of human and siamang ABHIi and MNSs blood groups using monoclonal antibodies and enzyme-modified erythrocytes showed a different organization of ABHIi in the siamang, and a greatly altered expression of the sialoglycoproteins that express MNSs. While several monoclonal antibodies to human MNSs sialoglycoproteins failed to agglutinate siamang erythrocytes, MoAb145, a monoclonal antibody that reacts with the MN sialoglycoprotein, agglutinated siamang erythrocytes to almost the same titer as human red blood cells. These studies suggest the potential usefulness of monoclonal antibodies in seroprimatology.
D000017:ABO Blood-Group System / Q000276:immunology*; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000957:Antigens, Viral, Tumor / Q000276:immunology; D002417:Cattle; D002522:Chlorocebus aethiops; D004591:Electrophoresis, Polyacrylamide Gel; D006168:Guinea Pigs; D006385:Hemagglutination Inhibition Tests; D006386:Hemagglutination Tests; D015186:Hominidae / Q000097:blood*; D006801:Humans; D006922:Hylobates / Q000097:blood* / Q000235:genetics / Q000276:immunology; D008951:MNSs Blood-Group System / Q000276:immunology*; D008253:Macaca mulatta; D011817:Rabbits; D051381:Rats; D012756:Sheep
D000017:ABO Blood-Group System; D000911:Antibodies, Monoclonal; D000957:Antigens, Viral, Tumor; D008951:MNSs Blood-Group System