Treatment of childhood neuroblastoma at the Clinic of Pediatric Oncology of the Faculty Hospital in Prague during 1965-1982.
The results of a complex treatment of 93 patients with neuroblastoma treated at the Clinic of Pediatric Oncology in Prague during the period of 1965-1982 are presented. A group of 41 patients treated during 1965-1977 was compared to that of 52 patients treated during 1978-1982. The latter group received a more intense chemotherapy treatment. In Group A there survived 7 patients (16.28%), all of them without symptoms of neuroblastoma. In Group B did so 31 patients (59.61%), 25 of them (48.08%) without symptoms of the disease, however, the results obtained in this group are of rather recent origin. A comparison made by means of the log-rank test and by extrapolating the data from curves of survival rates revealed no statistically significant improvement.
D000310:Adrenal Gland Neoplasms / Q000188:drug therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003604:Czechoslovakia; D005260:Female; D006258:Head and Neck Neoplasms / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000188:drug therapy; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D012186:Retroperitoneal Neoplasms / Q000188:drug therapy