Surface modification of polycarbonate with synthetic polyelectrolyte-anticoagulant activity.
Natural rubber with C = C bonds had been modified by reaction with chlorosulfonyl isocyanate (CSI) and 70% of the products were obtained, which yielded polyelectrolyte on treatment with NaOH, having sulfamate and carboxylate groups. The polyelectrolyte showed anticoagulant activity. This might be due to the presence of both sulfamate and carboxylate groups arranged in a steric manner in the molecule as that of Heparin. Surface energy parameters, platelet adhesion and plasma recalcification time were investigated. Possible comparison with heparin had been demonstrated.
D000925:Anticoagulants / Q000138:chemical synthesis*; D001672:Biocompatible Materials / Q000138:chemical synthesis*; D001769:Blood; D001777:Blood Coagulation; D002264:Carboxylic Acids / Q000138:chemical synthesis; D003485:Cyanates; D006493:Heparin / Q000138:chemical synthesis; D006801:Humans; D017953:Isocyanates; D010973:Platelet Adhesiveness; D011108:Polymers / Q000138:chemical synthesis*; D012408:Rubber; D013329:Structure-Activity Relationship; D013451:Sulfonic Acids / Q000138:chemical synthesis; D013499:Surface Properties
D000925:Anticoagulants; D001672:Biocompatible Materials; D002264:Carboxylic Acids; D003485:Cyanates; D017953:Isocyanates; D011108:Polymers; D013451:Sulfonic Acids; C041875:N-chlorosulfonyl isocyanate; D006493:Heparin; D012408:Rubber