[Sensitizing action of nonvirion admixtures in inactivated influenza vaccines in an experiment].
The side-effect of nonvirion admixtures in inactivated influenza vaccines has been experimentally studied. The minimal sensitizing dose of allantoic admixtures other than ovalbumin has been experimentally determined in vivo. This dose has proved to be 4 times higher than the sensitizing dose of ovalbumin. The presence of sharply defined correlations between the concentration of the admixtures contained in inactivated influenza vaccines, the titers of antibodies to these admixtures and the severity of anaphylactic reactions has been established in guinea pigs after their multiple immunization.
D000482:Allantois / Q000276:immunology; D000818:Animals; D000941:Antigens / Q000276:immunology; D002642:Chick Embryo; D004306:Dose-Response Relationship, Immunologic; D004340:Drug Contamination; D004912:Erythrocytes / Q000276:immunology; D006168:Guinea Pigs; D007114:Immunization; D007252:Influenza Vaccines / Q000276:immunology*; D010047:Ovalbumin / Q000276:immunology; D014613:Vaccines, Attenuated / Q000276:immunology
D000941:Antigens; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated; D010047:Ovalbumin
Izuchenie sensibiliziruiushchego deĭstviia nevirionnykh primeseĭ v inaktivirovannykh grippoznykh vaktsinakh v éksperimente.