Effect of intracerebroventricularly infused glucagon on feeding behavior.
Administration of pancreatic glucagon into 3rd cerebral ventricle of rats suppressed feeding with potency greater than 1000 times that of peripheral administration. A low dose of glucagon (5 ng) suppressed food intake mainly in short-term and slightly in long-term. A medium dose (25 ng) produced delayed feeding suppression. A high dose (100 ng) suppressed only short-term food intake. From this evidence, it is concluded that intracerebroventricular administration of physiological concentration of pancreatic glucagon suppresses short-term food intake through the hypothalamus. The possible mechanism of feeding suppression by glucagon is discussed.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects*; D005934:Glucagon / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005934:Glucagon