The effect of gastrectomy on pharmacokinetics of orally administered paracetamol in man.
Pharmacokinetics of paracetamol was investigated after administration of a single oral dose in patients with gastric and duodenal ulcers shortly before surgery and 4 weeks after partial Reichel-Poly gastrectomy. The course of changes of paracetamol concentrations was described with a two compartment model for extravascular administration. The calculations were carried out with an Odra 1300 computer. After gastrectomy the absorption of paracetamol was significantly depressed, particularly in patients with duodenal ulcers.
D000082:Acetaminophen / Q000008:administration & dosage / Q000378:metabolism*; D000284:Administration, Oral; D000328:Adult; D004381:Duodenal Ulcer / Q000378:metabolism / Q000601:surgery; D005260:Female; D005743:Gastrectomy; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011300:Preoperative Care; D013276:Stomach Ulcer / Q000378:metabolism / Q000601:surgery
D000082:Acetaminophen