title: [Immune and hormonal response to dimethylnitrosamine].
abstract: The study was concerned with assay of levels of 11- HOCS in blood and adrenal tissues and antibody-producing cells in the spleen as well as spontaneous rosette-formation by blood thymic and splenic lymphocytes in the course of carcinogenesis induced in experimental animals by nitrosodimethylamine treatment. Heightening of adrenal cortical function was registered at two stages: at an early stage of carcinogenesis--two months after nitrosodimethylamine treatment, and during tumor progression--after 7 months. Cellular immunity inhibition was observed at the said periods.
mesh_terms: D015062:11-Hydroxycorticosteroids / Q000097:blood; D000302:Adrenal Cortex / Q000503:physiopathology*; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D004128:Dimethylnitrosamine / Q000494:pharmacology*; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000276:immunology* / Q000503:physiopathology; D008297:Male; D051381:Rats; D012397:Rosette Formation; D013997:Time Factors
chemical_list: D015062:11-Hydroxycorticosteroids; D004128:Dimethylnitrosamine
vernacular_title: Immunnyĭ i gormonal'nyĭ otvet organizma na deĭstvie nitrozodimetilamina.