[HLA and rheumatoid purpura with or without nephropathy].
HLA profile was determined in 121 caucasoid children with rheumatoid purpura: out of those 55 developed nephropathy, of variable severity. HLA A and B were studied in all children, DR in 87. HLA BW 35 was more frequently found in total group of rheumatoid purpura (28,9%) and especially in nephropathies: 38,2% vs 20,4% in controls. However the increase is not significative even in nephropathy. On the other hand BW 35-DR 4 association is significatively higher in rheumatoid purpura with or without nephropathy than in controls. Analysis of 3 families with 2 affected sibs and 7 families with 1 affected child does not show any linkage with HLA. Determination of HLA profile does not allow to predict that the disease will be complicated by a nephropathy.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D011695:IgA Vasculitis / Q000150:complications / Q000276:immunology*; D007223:Infant; D007674:Kidney Diseases / Q000209:etiology / Q000276:immunology*; D008297:Male; D010375:Pedigree; D011379:Prognosis; D012306:Risk; D044465:White People
D006680:HLA Antigens
HLA et purpura rhumatoide avec ou sans néphropathie.