title: Quantitation of acetaminophen, chlorpheniramine maleate, dextromethorphan hydrobromide, and phenylpropanolamine hydrochloride in combination using high-performance liquid chromatography.
abstract: A high-performance liquid chromatographic (HPLC) method has been developed for the quantitation of acetaminophen, chlorpheniramine maleate, dextromethorphan hydrobromide, and phenylpropanolamine hydrochloride in combination in pharmaceutical dosage forms using a single column and three different mobile phases. The method developed is sensitive for the content uniformity test for tablets. No preliminary extraction procedure is required for liquid preparation and a very simple extraction procedure is required for tablets. The method is accurate and precise with RSD (based on five injections) of 1.2, 2.4, 1.9, and 1.6% for acetaminophen, chlorpheniramine, dextromethorphan, and phenylpropanolamine, respectively.
mesh_terms: D000082:Acetaminophen / Q000032:analysis*; D002744:Chlorpheniramine / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003915:Dextromethorphan / Q000032:analysis*; D004338:Drug Combinations; D007981:Levorphanol / Q000031:analogs & derivatives*; D010665:Phenylpropanolamine / Q000032:analysis*; D012996:Solutions; D013607:Tablets
chemical_list: D004338:Drug Combinations; D012996:Solutions; D013607:Tablets; D007981:Levorphanol; D010665:Phenylpropanolamine; D000082:Acetaminophen; D002744:Chlorpheniramine; D003915:Dextromethorphan