Effects of oxytocin and vasopressin on thoracic sympathetic preganglionic neurones in the cat.
When applied by iontophoresis onto single sympathetic preganglionic neurones in the intermediolateral nucleus of segments T1-T3 in the cat, oxytocin and vasopressin each had an excitatory effect. This effect consisted of a prolonged (30-300 sec) after-discharge following termination of application. These results indicate that oxytocin and vasopressin each exert excitatory effects on sympathetic preganglionic neurones and support the possibility that they may be chemical mediators of synaptic transmission in the intermediolateral nucleus, perhaps in cardioacceleratory and/or pressor pathways descending from the paraventricular nucleus of the hypothalamus.
D000818:Animals; D001339:Autonomic Fibers, Preganglionic / Q000187:drug effects*; D002415:Cats; D007478:Iontophoresis; D008236:Lypressin / Q000494:pharmacology*; D010121:Oxytocin / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013564:Sympathetic Nervous System / Q000187:drug effects*
D010121:Oxytocin; D008236:Lypressin