Comparative effects of various lead salts on delayed hypersensitivity in mice.
Intraperitoneal administration of lead acetate, lead carbonate, lead chloride, lead nitrate or lead oxide at 0.5 or 6 mg per kg per day on five consecutive days was found to produce diverging effects on delayed hypersensitivity to sheep erythrocytes in Balb/c mice according to the salt used. Lead carbonate, lead nitrate and lead oxide exerted immunosuppressing properties, while lead acetate and lead chloride enhanced this cell-mediated immune response. From these findings, it is concluded that lead immunotoxicity critically depends on which salt is present.
D000818:Animals; D002254:Carbonates / Q000633:toxicity; D005260:Female; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular / Q000187:drug effects; D007854:Lead / Q000633:toxicity*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009566:Nitrates / Q000633:toxicity; D009942:Organometallic Compounds
D002254:Carbonates; D009566:Nitrates; D009942:Organometallic Compounds; D007854:Lead; C043262:lead carbonate; C029891:lead chloride; C017461:lead nitrate; C028356:lead tetroxide; C008261:lead acetate