Selective depletion of norepinephrine in brain by N-2-chloroethyl-N-ethyl-2-bromobenzylamine fails to alter the voluntary consumption of ethanol in rats.
The effects of the selective norepinephrine neurotoxin, DSP-4, on the maintenance of voluntary consumption of ethanol was tested in male Long-Evans rats. The drug, DSP-4, produced a 51% reduction in whole brain levels of NE without affecting the consumption of ethanol. These results, however, do not rule out a role for NE in mediating this behavior.
D000428:Alcohol Drinking; D000588:Amines / Q000494:pharmacology*; D000818:Animals; D001596:Benzylamines / Q000494:pharmacology*; D001679:Biogenic Amines / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009498:Neurotoxins / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D000588:Amines; D001596:Benzylamines; D001679:Biogenic Amines; D009498:Neurotoxins; C012102:DSP 4; D009638:Norepinephrine