title: Protection with butylated hydroxytoluene and other compounds against intoxication and mortality caused by hexachlorophene.
abstract: The antioxidants butylated hydroxytoluene (BHT) and ethoxyquin protected rats against intoxication and mortality normally produced by hexachlorophene (HCP, 100 mg/kg). BHT also prevented the elevation of cerebrospinal fluid pressure, a central nervous system effect of HCP poisoning. In addition, both phenobarbital and SKF-525A protected against HCP poisoning, with the barbiturate also offering significant protection against triethyltin. L-Ascorbic acid, vitamin E, N,N-diphenyl-p-phenylenediamine and reduced and oxidized glutathione over a range of doses were ineffective in preventing HCP lethality. The protective effect of phenobarbital against HCP and triethyltin intoxication further supports existing evidence of a common or similar mechanism of toxic action for these two structurally dissimilar compounds.
mesh_terms: D000818:Animals; D000931:Antidotes / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology; D001929:Brain Edema / Q000517:prevention & control; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D004487:Edema / Q000517:prevention & control; D006582:Hexachlorophene / Q000037:antagonists & inhibitors / Q000506:poisoning*; D007427:Intracranial Pressure / Q000187:drug effects; D008297:Male; D051381:Rats; D014267:Triethyltin Compounds / Q000506:poisoning
chemical_list: D000931:Antidotes; D000975:Antioxidants; D014267:Triethyltin Compounds; D002084:Butylated Hydroxytoluene; D006582:Hexachlorophene