Antifungal activity of four antifungal drugs in the cutaneous retention time test.
The protective prophylactic activity of tolciclate, bifonazole, oxiconazole and Ro 14-4767/002 which may reflect their presence in the horny layer was examined in guinea pigs. Guinea pigs were topically treated with the drug and infected on the application site with Trichophyton mentagrophytes spores at various time intervals. Tolciclate showed the highest prophylactic activity, followed by oxiconazole, Ro 14-4767/002 and bifonazole.
D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006168:Guinea Pigs; D007093:Imidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D009025:Morpholines / Q000008:administration & dosage / Q000627:therapeutic use*; D009824:Ointments; D013859:Thiocarbamates / Q000008:administration & dosage / Q000627:therapeutic use; D014005:Tinea / Q000517:prevention & control*; D014249:Trichophyton
D000935:Antifungal Agents; D007093:Imidazoles; D009025:Morpholines; D009824:Ointments; D013859:Thiocarbamates; C038974:amorolfine; C022155:oxiconazole; C036596:bifonazole; C013305:tolciclate