Synthesis of 2-carbalkoxyamino-5(6)-(1-substituted piperazin-4-yl/piperazin-4-ylcarbonyl)benzimidazoles and related compounds as potential anthelmintics.
A number of 1,4-di-(3,4-disubstituted benzoyl)piperazines (3-6), 1-(3,4-disubstituted benzoyl)-4-(3,4-disubstituted phenyl)piperazines (9-11), 1,4-di-(2-carbalkoxyaminobenzimidazol-5(6)-yl-carbonyl)piperazines (12, 13), 1-(2-carbalkoxyaminobenzimidazol-5(6)- ylcarbonyl)-4-(2-carbalkoxyaminobenzimidazol-5(6)-yl) piperazines (14, 15) and 1-(2-carbalkoxyaminobenzimidazol-5(6)-yl)-4-(N,N- dicarbalkoxyamidino)piperazines (17, 18) have been synthesized and their anthelmintic activity is reported.
D000724:Ancylostomiasis / Q000188:drug therapy; D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis* / Q000627:therapeutic use; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D006224:Cricetinae; D006925:Hymenolepiasis / Q000188:drug therapy; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000871:Anthelmintics; D001562:Benzimidazoles; D010879:Piperazines