title: [Morphogenetic role of the cortical cytoskeleton and plasma membrane of the ovum].
abstract: The classical embryological conception of egg cortex localization of morphogenetic determinants is interpreted in terms of current data on cell cortex and cell surface organization. The egg surface complex that involves cortical cytoskeleton--oolemma (stabilized with transmembrane linkage between the cytoskeleton and ligands of egg envelope extracellular matrix) presumably ensures storage of cortical morphogenetic information, i.e. the spatial memory of egg and zygote as a heterogeneous distribution of membrane and cortex components. Any of the rigid cortical complex component--membrane receptors, structural cytoskeletal proteins and also embedded in cortical gel-like framework of actin filaments RNP's and non-structural proteins (e.g. enzymes) may function as possible morphogenetic determinants. The coupling of general cortical rigidity and local contractility during the cleavage may be accounted (after Condeelis, 1981) for the actin-myosin interaction following a local dissociation of the stiff structural complex of actin--actin-binding proteins.
mesh_terms: D000199:Actins / Q000502:physiology; D000818:Animals; D001757:Blastomeres / Q000166:cytology / Q000502:physiology; D002455:Cell Division; D002970:Cleavage Stage, Ovum / Q000502:physiology / Q000648:ultrastructure; D003593:Cytoplasm / Q000502:physiology / Q000648:ultrastructure*; D003599:Cytoskeleton / Q000502:physiology / Q000648:ultrastructure; D005260:Female; D005786:Gene Expression Regulation; D008870:Microtubules / Q000502:physiology / Q000648:ultrastructure; D008938:Mitosis; D009024:Morphogenesis; D009940:Organoids / Q000502:physiology / Q000648:ultrastructure; D010063:Ovum / Q000502:physiology / Q000648:ultrastructure*; D011485:Protein Binding; D013499:Surface Properties; D015044:Zona Pellucida / Q000502:physiology / Q000648:ultrastructure*; D015053:Zygote / Q000502:physiology / Q000648:ultrastructure
chemical_list: D000199:Actins
vernacular_title: O morfogeneticheskoĭ roli kortikal'nogo tsitoskeleta i plazamaticheskoĭ membrany iaĭtsekletki.