Preparation of a 211At-IgG conjugate which is stable in vivo.
The short lived (t 1/2 7.2 h) alpha-particle emitting halogen 211At has been attached to an antibody by using an acylation reaction to conjugate para-[211At]astato-benzoic acid with rabbit IgG. The conjugate, which is stable in vivo, contains at least 30% of the initial activity of 211At.
D000818:Animals; D001246:Astatine; D004355:Drug Stability; D007074:Immunoglobulin G; D007553:Isotope Labeling / Q000379:methods; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA
D007074:Immunoglobulin G; D001246:Astatine