Non-linear accumulation of gentamicin in guinea-pig kidney.
The dose dependence of gentamicin renal uptake in guinea-pigs was studied. The concentration of gentamicin in the kidneys was determined 2 h post administration. The plot of gentamicin concentration vs. dose over the range 0.3-48 mg/kg iv revealed nonlinearity of the uptake. As the delivery of gentamicin to proximal tubule cells apparently obeys first order kinetics, the nonlinear process should occur at the cellular uptake level.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005839:Gentamicins / Q000097:blood / Q000378:metabolism*; D006168:Guinea Pigs; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism*; D007700:Kinetics; D008297:Male
D005839:Gentamicins