[Sister chromatid exchanges induced in human lymphocyte chromosomes by trifluralin, atrazine and simazine].
Many epidemiological and experimental "in vivo" studies have proved in recent years the carcinogenic properties of herbicides. In order to evaluate the "in vitro" action on the human DNA of Trifluralin, Atrazine and Simazine (active principles of herbicides Treflan and Fogard S respectively) the authors have studied the rates of SCE in cultures of human lymphocytes exposed to different concentrations of a solution 1 ppm of the substances. Trifluralin and Simazine, but not Atrazine, increase SCE per cell, with statistical significance, in the cultures with the highest concentrations of these substances. (SCE per cell: Trifluralin 5.27 +/- 1.38, Simazine 5.09 +/- 1.19, Control 3.51 +/- 1.14).
D001280:Atrazine / Q000494:pharmacology*; D006540:Herbicides / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D012839:Simazine / Q000494:pharmacology*; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D014052:Toluidines / Q000494:pharmacology*; D014274:Trifluralin / Q000494:pharmacology*
D006540:Herbicides; D014052:Toluidines; D014274:Trifluralin; D001280:Atrazine; D012839:Simazine
Sce (sister chromatid exchanges) indotti nei cromosomi dei linfociti umani da trifluralin, atrazina e simazina.