Pharmacokinetics and bioavailability of theophylline in horses.
The pharmacokinetics and bioavailability of theophylline in horses were investigated following both intravenous and intragastric administration of aminophylline solutions at doses corresponding to 15 and 10 mg/kg theophylline base. A rapid distributive phase with a half-life of approximately 15-30 min was followed by a slower elimination half-life averaging 15-17 h. The apparent volume of distribution averaged 850-900 ml/kg. Theophylline, administered as aminophylline solution, was both rapidly and completely absorbed from the equine digestive tract. Based on the bioavailability and disposition kinetics of theophylline, an intragastric dosage regimen for aminophylline consisting of the administration of 5 mg/kg at 12 h intervals would be expected to maintain plasma theophylline concentrations within the therapeutic range.
D000628:Aminophylline / Q000378:metabolism; D000818:Animals; D001682:Biological Availability; D001798:Blood Proteins / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006207:Half-Life; D006736:Horses / Q000378:metabolism*; D007700:Kinetics; D011485:Protein Binding; D013806:Theophylline / Q000097:blood / Q000378:metabolism*
D001798:Blood Proteins; D000628:Aminophylline; D013806:Theophylline