Additional studies on pregnancy termination and inhibition of the monkey corpus luteum with 5-oxa-17-phenyl-18,19,20-trinor-PGF1 alpha methyl ester and structurally related prostaglandins.
Oral administration of 5-oxa-17-phenyl-18,19,20-trinor-PGF1 alpha methyl ester (PGF-analog) resulted in a consistent and dose-dependent inhibition of corpus luteum progesterone production in nonpregnant rhesus monkeys concomitantly treated with human chorionic gonadotropin. Similarly, vaginal suppositories containing PGF-analog also inhibited the monkey corpus luteum. Side effects by the oral route of administration were minimal, whereas side effects following vaginal treatment with PGF-analog were higher. Five prostaglandins with structural similarity to PGF-analog were studied for their ability to inhibit the monkey corpus luteum, but none showed an advantage over the parent molecule. PGF-analog did not synergize with 9-deoxo-16,16-dimethyl-9-methylene-PGE2 for the inhibition of the monkey corpus luteum, nor did it synergize with (15S)-15-methyl-PGF2 alpha methyl ester for the interruption of early pregnancy in the monkey. 9-Deoxo-9-methylene-5-oxa-17-phenyl-18,19-20-trinor-PGE1 methyl ester did not terminate early gestation in the monkey at doses of 8 or 24 mg.
D000019:Abortifacient Agents / Q000494:pharmacology*; D000020:Abortifacient Agents, Nonsteroidal / Q000494:pharmacology*; D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D003338:Corpus Luteum / Q000187:drug effects / Q000502:physiology*; D005260:Female; D008253:Macaca mulatta; D008598:Menstruation / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011374:Progesterone / Q000097:blood; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000019:Abortifacient Agents; D000020:Abortifacient Agents, Nonsteroidal; D006063:Chorionic Gonadotropin; D011461:Prostaglandins F, Synthetic; D011374:Progesterone; C041755:5-oxa-17-phenyl-18,19,20-trinor prostaglandin F1 alpha methyl ester