Nephrotic syndrome with reversible severe renal failure after gold therapy.
A patient with rheumatoid arthritis developed nephrotic syndrome with reversible renal failure following gold therapy. Histological examination of renal biopsy disclosed the typical picture of membranous nephropathy. After prolonged treatment with steroids and cyclophosphamide, complete recovery was achieved. The likely mechanism involved and the clinical implications are discussed.
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000188:drug therapy; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001794:Blood Pressure / Q000187:drug effects; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D006046:Gold / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D009404:Nephrotic Syndrome / Q000139:chemically induced* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use
D006046:Gold; D003520:Cyclophosphamide; D011241:Prednisone