The plasma and erythrocyte fatty acid composition of poorly controlled, insulin-dependent (type I) diabetic patients and the effect of improved metabolic control.
Analysis of the plasma and erythrocyte fatty acid composition of poorly controlled, insulin-dependent (type I) diabetic patients revealed a low level of 18:3c, omega 6, 20:3c, omega 6, 22:6c, omega 3 and total polyunsaturated fatty acids, and a high level of 18:0 and total saturated fatty acids. Improvement of diabetic control, achieved by treatment with continuous subcutaneous insulin infusion coincided with an increase of arachidonic acid and a normalization of total polyunsaturated fatty acids, with a concomitant decrease of total saturated fatty acids and total monounsaturated fatty acids, especially 18:1c, omega 9. The results of this study can be important for the dietary advice to poorly controlled, diabetic patients.
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood* / Q000628:therapy; D004912:Erythrocytes / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood*; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D010743:Phospholipids / Q000097:blood; D010949:Plasma / Q000378:metabolism; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D002784:Cholesterol; D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D006442:Glycated Hemoglobin; D010743:Phospholipids; D014280:Triglycerides