Central effects of aldosterone infused into the rat subcommissural organ region.
D-Aldosterone (5 ng/microliter/h) was infused for 6 days into the region of the subcommissural organ (SCO) of conscious, adult male Sprague-Dawley rats. Aldosterone increased urinary sodium loss and the sodium/potassium ratio. Although probably central in origin, these effects still occurred when cannulae were displaced up to 1 mm from the targeted SCO placement. Aldosterone decreased adrenal medullary cross-sectional area without affecting cell density. This effect was highly dependent on proper cannula placement and was not observed when the cannula tip was not in contact with the cerebrospinal fluid of the pineal recess over the rostral two-thirds of the SCO. We conclude that aldosterone increases sodium excretion by an action in the SCO and/or adjacent structures. We also postulate a negative trophic relationship between mineralocorticoids and the adrenal medulla mediated by the SCO.
D000311:Adrenal Glands / Q000033:anatomy & histology / Q000187:drug effects*; D000450:Aldosterone / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D001834:Body Water / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002452:Cell Count; D006706:Homeostasis / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D009490:Neurosecretory Systems / Q000187:drug effects*; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism; D013351:Subcommissural Organ / Q000187:drug effects*
D000450:Aldosterone; D012964:Sodium; D011188:Potassium