Intravenous nicardipine in patients with chronic heart failure: a nuclear stethoscope study.
The effects of intravenous nicardipine (10 mg) on some aspects of left ventricular function have been studied with a radioisotope method in 10 male patients in chronic heart failure (NYHA Class II and III). Blood pressure (mean +/- s.d.) fell from 133 +/- 26/86 +/- 11 mm Hg to 103 +/- 22/69 +/- 13. Heart rate rose from 67 +/- 9 beats per minute to 85 +/- 10. Left ventricular ejection fraction rose from 31 +/- 7% to 38 +/- 6% and relative cardiac output from 24 +/- 9 to 41 +/- 11 (P less than 0.001 in all cases). This suggests that nicardipine has a potent vasodilator effect which results in increased left ventricular pumping activity in patients with mild to moderate heart failure.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000494:pharmacology* / Q000627:therapeutic use; D002302:Cardiac Output / Q000187:drug effects; D006333:Heart Failure / Q000188:drug therapy / Q000503:physiopathology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D009529:Nicardipine; D009543:Nifedipine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D002121:Calcium Channel Blockers; D009529:Nicardipine; D009543:Nifedipine