[Administration of tetracycline to the intact and thyroidectomized rat: its effect on the ultrastructure of hepatocytes, lipids in the liver and plasma].
Tetracycline hydrochlorohydrate was administered to fed adult female rats. Ultrastructural hepatocytes, liver and plasmatic lipids were studied. Tetracycline administration induced a fatty liver in both euthyroid and thyroidectomized group. Blockade of formation or release of lipoproteins into plasma in thyroidectomized rats occurred earlier than in intact ones. In intoxicated thyroidectomized rats, REG was disorganized, and Golgi was poorly loaded with VLDL particles whereas in intact rats REG was regular and Golgi vesicles were hypertrophied. Serum FFA increased only in the thyroidectomized rats after tetracycline.
D000818:Animals; D005260:Female; D008055:Lipids / Q000032:analysis*; D008099:Liver / Q000032:analysis*; D008854:Microscopy, Electron; D051381:Rats; D011919:Rats, Inbred Strains; D013752:Tetracycline / Q000494:pharmacology*; D013961:Thyroid Gland / Q000648:ultrastructure*; D013965:Thyroidectomy
D008055:Lipids; D013752:Tetracycline
Administration de tétracycline au rat intact et éthyroïdé: ses effets sur l'ultrastructure des hépatocytes, les lipides du foie et du plasma.