title: [Malignant thymoma with polymorphic exanthema and erosive mucous membrane changes].
abstract: We report on a 30-year-old female patient with therapy-refractory polymorphous exanthema and widespread erosions in the oral and genital mucosa. The alterations demonstrated in the skin and genital mucosa were associated with a malignant thymoma with metastases being interpretatet as a paraneoplastic syndrome. There was a remarkably large spectrum of circulating antibodies, which had no corresponding clinical correlation. Our examination results indicate a dysregulation between cellular and humoral immunity, obviously caused by the malignant thymoma, with an extraordinary, uncontrolled production of antibodies against structures belonging to the body and alien structures.
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D005076:Exanthema / Q000473:pathology*; D005260:Female; D006801:Humans; D009092:Mucous Membrane / Q000473:pathology*; D010257:Paraneoplastic Syndromes / Q000473:pathology; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology / Q000556:secondary*; D012883:Skin Ulcer / Q000473:pathology; D013945:Thymoma / Q000276:immunology / Q000473:pathology / Q000556:secondary*; D013950:Thymus Gland / Q000473:pathology; D013953:Thymus Neoplasms / Q000276:immunology / Q000473:pathology*
chemical_list: D001323:Autoantibodies
vernacular_title: Malignes Thymom mit polymorphem Exanthem und erosiven Schleimhautveränderungen.