Tissue sensitivity to acetylcholine, adrenaline, noradrenaline and serotonin and agents acting on sulphydryl groups.
Parachloromercury benzoate (PCMB), a sulphydryl inactivator, caused a progressively increasing inhibition of tissue responses to acetylcholine, adrenaline, noradrenaline and serotonin in vitro. This inhibition was progressively and completely reversed by penicillamine, a sulphydryl activator. It is inferred that intact sulphydryl groups are essential for constancy of responses of excitable tissues to the neurotransmitters.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D002729:Chloromercuribenzoates / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology*; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology*; D010396:Penicillamine / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D020245:p-Chloromercuribenzoic Acid
D002729:Chloromercuribenzoates; D013438:Sulfhydryl Compounds; D012701:Serotonin; D020245:p-Chloromercuribenzoic Acid; D010396:Penicillamine; D000109:Acetylcholine; D009638:Norepinephrine; D004837:Epinephrine