title: Blockade of dopamine-induced chemosensory inhibition by domperidone.
abstract: The sensory discharges from the carotid body chemoreceptors of the cat are transiently inhibited by dopamine (DA) injections. This chemosensory inhibition was effectively blocked by domperidone, a selective antagonist of D2 dopaminoceptors. The basal frequency of spontaneous chemosensory impulses was immediately and sustainly increased after domperidone, suggesting the withdrawal of a tonic inhibition of chemosensory discharges by endogenous DA released from glomus cells. The peripheral dopaminergic modulation of chemoreflexes may be separately blocked by domperidone, a drug unable to cross the blood-brain barrier.
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D002344:Carotid Body / Q000187:drug effects*; D002415:Cats; D004294:Domperidone / Q000494:pharmacology*; D018492:Dopamine Antagonists; D004305:Dose-Response Relationship, Drug
chemical_list: D018492:Dopamine Antagonists; D004294:Domperidone