[The bioenergy aspect of the mechanism of action of phlogolytics and its study using dielectric spectrometry].
Free radical metabolism was discovered to correlate with dielectric characteristics of the tissue. The time-course of the rate of liver tissue relaxation mirrors the status of the detoxifying antioxidant system. The effects of phlogolytics on the time-course of the dielectric characteristics of liver tissue under autolysis indicate that their action is mediated via free radical endoplasmic oxidation aimed at detoxification and repair.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism; D004734:Energy Metabolism / Q000187:drug effects*; D005609:Free Radicals; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D013053:Spectrophotometry / Q000379:methods; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D005609:Free Radicals
Bioénergeticheskiĭ aspekt mekhanizma deĭstviia flogolitikov i ego izuchenie s pomoshch'iu diél'spektrometrii.