title: Adaptations to reduction of endometrial surface available for placental development in sheep.
abstract: On Day 5 of pregnancy, before the blastocyst migrates to the uterus, one uterine horn was ligated to restrict the trophoblast to the lumen ipsilateral to the corpus luteum. The numbers of placentomes (caruncles and cotyledons) were reduced by half, but neither at 120 nor at 140 days of pregnancy (term 147 days) did the weights of placentae and fetuses of treated ewes differ significantly from those of control ewes. Amongst uterus-ligated animals prepared for chronic study, the rate of uterine blood flow (electromagnetic flow transducer, ml/min) to the pregnant horn was higher than in control ewes, as was the concentration of progestagens in maternal peripheral blood. There may be a compensatory response that causes hypertrophy of placentomes and that increases blood flow to the uterine horn containing placental tissue.
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D005314:Embryonic and Fetal Development; D004717:Endometrium / Q000502:physiology*; D004970:Estrone / Q000097:blood; D005260:Female; D005333:Fetus / Q000033:anatomy & histology; D008026:Ligation; D009929:Organ Size; D010920:Placenta / Q000033:anatomy & histology / Q000502:physiology*; D011247:Pregnancy; D011372:Progestins / Q000097:blood; D012039:Regional Blood Flow; D012756:Sheep; D014599:Uterus / Q000098:blood supply
chemical_list: D011372:Progestins; D004970:Estrone