[Safety and effectiveness study of the aerosol method of administering inactivated influenza chromatographic vaccine in an experiment].
Experiments in laboratory animals demonstrated safety, areactogenicity, and low allergenic potential of inactivated influenza chromatographic vaccine (IICV) administered by aerosol method. Aerosol immunization of white rats resulted in the development of the same level of secretory antibody as after intraperitoneal inoculation of IICV but the immunizing aspirational dose was 10-20 times as low as parenteral. Marked protection of mice was achieved after triple aerosol immunization of immunologically experienced animals.
D000336:Aerosols; D000707:Anaphylaxis / Q000276:immunology; D000818:Animals; D000914:Antibodies, Viral / Q000032:analysis; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D007114:Immunization / Q000379:methods; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage / Q000276:immunology / Q000633:toxicity*; D007273:Injections, Intramuscular; D051379:Mice; D051381:Rats; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology / Q000633:toxicity
D000336:Aerosols; D000914:Antibodies, Viral; D007252:Influenza Vaccines; D014613:Vaccines, Attenuated
Izuchenie bezvrednosti i éffektivnosti aérozol'nogo metoda vvedeniia inaktivirovannoĭ grippoznoĭ khromatograficheskoĭ vaktsiny v éksperimente.