The influence of cigarette smoke and treatment with contraceptive hormones on the fibrinolytic activity in the rat.
The fibrinolytic activity in the vessel wall (FAV), in plasma and in euglobulin solution (FAE) was determined in rats exposed to cigarette smoke in an inhalation chamber or treated with contraceptive hormones. In the smoke-exposed rats increased FAE and significantly decreased FAV were demonstrated. No effect on fibrinolysis was recorded in the hormone-treated rats, in which mean plasma levels of ethinylestradiol and d-norgestrel were 74 pg/ml and 0.17 ng/ml, respectively, six hours after the last subcutaneous administration.
D000818:Animals; D001808:Blood Vessels / Q000187:drug effects / Q000378:metabolism; D003276:Contraceptives, Oral / Q000633:toxicity*; D003277:Contraceptives, Oral, Combined / Q000633:toxicity*; D004997:Ethinyl Estradiol / Q000633:toxicity; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D009644:Norgestrel / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains; D012907:Smoking
D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D009644:Norgestrel; D004997:Ethinyl Estradiol