title: Detection of HBs-Ag in the pancreas in cases of pancreatic carcinoma.
abstract: Detection of HBs-Ag in the pancreatic juice in acute and chronic hepatic failure caused by hepatitis-B-infection leads to the assumption that parts of that virus are produced by the pancreas. We investigated pancreatic tissue obtained during Whipple's procedure in 51 cases of pancreatic carcinoma. In 5 specimens HBs-Ag was detected, mostly located in acinar cells and inside small ducts. In view of our knowledge of the carcinogenesis of human hepatocellular carcinoma, hepatitis B virus could produce an oncogenic effect in pancreatic carcinoma, too.
mesh_terms: D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D010179:Pancreas / Q000032:analysis*; D010190:Pancreatic Neoplasms / Q000032:analysis* / Q000209:etiology
chemical_list: D006514:Hepatitis B Surface Antigens