Early clinicopathologic findings in dogs ingesting ethylene glycol.
Fifteen dogs were given 9.5 ml of ethylene glycol/kg of body weight, orally. Physical examination and clinical laboratory findings were evaluated at 1 and 3 hours after ingestion. Three of these dogs were also evaluated at 6, 9, 12, 24, 48, and 72 hours after ingestion. At 1 and 3 hours, the dogs were depressed, ataxic, and polydipsic with increased urine output and serum osmolality. Plasma bicarbonate and urine osmolality were decreased. The osmolal and anion gaps were increased at 1 and 3 hours, respectively. Calcium oxalate crystalluria was first observed at 6 hours. Diminished renal excretory function was not evident until 48 hours. Depression, ataxia, metabolic acidosis, polydipsia, and polyuria in the presence of serum hyperosmolality were early (1 and 3 hour) findings that indicated ethylene glycol intoxication in dogs.
D000818:Animals; D001806:Blood Urea Nitrogen; D002129:Calcium Oxalate / Q000652:urine; D004283:Dog Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D004285:Dogs; D019855:Ethylene Glycol; D005026:Ethylene Glycols / Q000097:blood / Q000506:poisoning* / Q000652:urine; D005260:Female; D008297:Male; D009994:Osmolar Concentration; D010758:Phosphorus / Q000097:blood
D005026:Ethylene Glycols; D002129:Calcium Oxalate; D010758:Phosphorus; D019855:Ethylene Glycol