Associative learning and regulation of immune responses.
Conventional genetically inbred mice were exposed to an immunologically inert stimulus (CS) along with a stimulus known to perturb immune functioning [either non-specifically, an immunosuppressive drug; or specifically, an antigen]. After repeated trials of this type subsequent re-exposure of such "conditioned mice" to the CS alone was found to produce a change in immune response potential. This phenomenon has been examined in situations as diverse as those in which the test antigenic challenge is a tumour cell innoculum, or a tissue allograft. Some possible clinical implications of these findings are discussed.
D000818:Animals; D000917:Antibody Formation; D001245:Association Learning / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology; D003463:Cues; D003520:Cyclophosphamide / Q000494:pharmacology; D005108:Extinction, Psychological / Q000502:physiology; D006084:Graft Rejection; D007109:Immunity; D007694:Killer Cells, Natural / Q000276:immunology; D007858:Learning / Q000502:physiology*; D051379:Mice; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA
D003520:Cyclophosphamide