title: Practical application of the concept of mean times in biopharmaceutics.
abstract: The "concept of mean times" (1) in combination with the "method of moments" (3, 4) provides a practical basis for handling biopharmaceutical problems. This holds for in vitro, in vitro/in vivo and in vivo situations. Using several examples, it was demonstrated that questions concerning the comparability of in vitro dissolution models and their in vivo relevance can be answered, and that the rate of bioavailability can be evaluated exactly.
mesh_terms: D000818:Animals; D001682:Biological Availability; D001702:Biopharmaceutics; D006801:Humans; D066298:In Vitro Techniques; D008954:Models, Biological; D012995:Solubility; D013997:Time Factors