Thyroid-testis interrelationship during the development and sexual maturity of the rat.
The effects of thyroidectomy and treatment with thyroxine (T4) were studied in immature male rats to evaluate the role of the thyroid in the development of testicular functions. Thyroidectomy inhibited gametogenesis and development of the Leydig cell in these rats. However, the effects could be reversed by administration of 10 micrograms T4 (i.p.) daily for 30 days.
D000818:Animals; D007985:Leydig Cells / Q000187:drug effects; D008297:Male; D009929:Organ Size; D051381:Rats; D012671:Seminiferous Tubules / Q000187:drug effects; D012741:Sexual Maturation; D013091:Spermatogenesis; D013737:Testis / Q000502:physiology*; D013961:Thyroid Gland / Q000502:physiology*; D013965:Thyroidectomy; D013974:Thyroxine / Q000494:pharmacology
D013974:Thyroxine