Red cell metabolism: a comparative study of some mammalian species.
The activities of six enzymes--glucose-6-phosphate dehydrogenase (G-6-PD), 6-phosphogluconate dehydrogenase (6-PGD), glutathione reductase (GR), glutathione peroxidase (GSH-Px), catalase and superoxide dismutase (SOD)--and levels of reduced glutathione (GSH) and GSH regeneration rates were measured in the red blood cells of eight mammalian species--rabbit, guinea-pig, rat, golden hamster, sheep, goat, cattle and human. The results show that whereas the activities of G-6-PD, 6-PGD and GR are widely different among the experimental animals, there is no such variation in the activity of SOD. There does not appear to be a relationship between GSH regeneration rate and the activities of G-6-PD, 6-PGD and GR--the enzymes associated with GSH metabolism.
D000818:Animals; D002374:Catalase / Q000097:blood; D006224:Cricetinae; D004912:Erythrocytes / Q000201:enzymology*; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005978:Glutathione / Q000097:blood; D005979:Glutathione Peroxidase / Q000097:blood; D005980:Glutathione Reductase / Q000097:blood; D006041:Goats; D006168:Guinea Pigs; D006801:Humans; D007700:Kinetics; D008647:Mesocricetus; D010734:Phosphogluconate Dehydrogenase / Q000097:blood; D011817:Rabbits; D051381:Rats; D012756:Sheep; D013045:Species Specificity; D013482:Superoxide Dismutase / Q000097:blood
D010734:Phosphogluconate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione