Diglyceryl lipase activity in mouse platelets.
These studies reveal for the first time that mouse platelets have substantial diglyceryl lipase (DGL) activity (138 +/- 29 nmols/hr/10(9) platelets) compared with human 37 +/- 56 nmols/hr/10(9) platelets) or rat platelets (25 +/- 11 nmols/hr/10(9) platelets). Our demonstration of the enzyme in rat platelets contrasts with the scant activity of DGL in that species as reported by others. The activity of DGL in mouse platelets was inhibited by RHC80267, an agent previously described as an inhibitor of DGL in dog and rat platelets.
D000818:Animals; D001792:Blood Platelets / Q000201:enzymology*; D003512:Cyclohexanones / Q000494:pharmacology; D006801:Humans; D008071:Lipoprotein Lipase / Q000037:antagonists & inhibitors / Q000097:blood*; D051379:Mice / Q000097:blood*; D010741:Phospholipases A / Q000037:antagonists & inhibitors; D051381:Rats; D013045:Species Specificity; D010738:Type C Phospholipases / Q000037:antagonists & inhibitors
D003512:Cyclohexanones; C036535:1,6-bis(cyclohexyloximinocarbonyl)hexane; D010741:Phospholipases A; D008071:Lipoprotein Lipase; D010738:Type C Phospholipases