Prevention of methionine and ammonia-induced coma by intravenous infusion of a branched chain amino acid solution to rats with liver injury.
The prevention of hepatic encephalopathy by the intravenous infusion of a branched chain amino acid (BCAA)-enriched solution was investigated in methionine and ammonium acetate-treated rats whose liver was already injured with carbon tetrachloride. A BCAA-enriched solution protected the rats from entering a coma. The brain BCAA contents became higher, and the brain methionine and tyrosine levels and the ratio of glutamine to glutamic acid in the brain diminished after administering the BCAA-enriched solution.
D000085:Acetates / Q000633:toxicity*; D000596:Amino Acids / Q000032:analysis; D000597:Amino Acids, Branched-Chain / Q000627:therapeutic use*; D000818:Animals; D001923:Brain Chemistry; D002252:Carbon Tetrachloride Poisoning / Q000150:complications; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications*; D006501:Hepatic Encephalopathy / Q000139:chemically induced / Q000517:prevention & control*; D008297:Male; D008715:Methionine / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D000085:Acetates; D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D008715:Methionine; C018824:ammonium acetate