title: Anatomic basis of transcortical motor aphasia.
abstract: Analysis of language profiles and CT anatomy in transcortical motor aphasia (TCMA) suggests that the essential lesion is disruption of connections at sites between the supplementary motor area and the frontal perisylvian speech zone. If the lesion is extended, there may also be poor articulation (lesion deep to motor strip for face), impaired auditory comprehension (lesion in anterior head of caudate, anterior limb internal capsule, anterior putamen, and anterior portion of external capsule, claustrum, extreme capsule, and insula), or stuttering (lesion in pars opercularis and lower third of premotor region). This concept unifies disparate anatomic and psychophysiologic observations about three syndromes: classical TCMA, aphasia after left medial frontal infarction, and TCMA during recovery from Broca's aphasia.
mesh_terms: D000328:Adult; D000368:Aged; D001037:Aphasia / Q000503:physiopathology*; D001039:Aphasia, Broca / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology*; D001184:Articulation Disorders / Q000503:physiopathology; D001307:Auditory Perception; D001921:Brain / Q000000981:diagnostic imaging*; D002543:Cerebral Hemorrhage / Q000150:complications; D002544:Cerebral Infarction / Q000150:complications; D005625:Frontal Lobe / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed