The immunomodulatory property of a novel synthetic compound adamantylamide dipeptide.
The adjuvant effect of a novel synthetic compound adamantylamide dipeptide (AdDP) was tested in a model of delayed hypersensitivity to ovalbumin in guinea pigs, and of immunostimulatory activity in the experiments with 3H thymidine where DNA biosynthesis was measured in several immunocompetent organs after administration of adamantylamide dipeptide. In both tests, the compound proved to be active since delayed hypersensitivity was potentiated and a marked increase in the utilization of 3H thymidine in liver, thymus and spleen has been observed. The novel compound appeared to be devoid of other effects of MDP such as pyrogenicity and arthritogenicity.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000276:immunology; D000276:Adjuvants, Immunologic; D000547:Amantadine / Q000031:analogs & derivatives* / Q000276:immunology; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004247:DNA / Q000378:metabolism; D004151:Dipeptides / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D008297:Male; D010047:Ovalbumin; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
D000276:Adjuvants, Immunologic; D004151:Dipeptides; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C044891:adamantylamide-alanyl-isoglutamine; D010047:Ovalbumin; D004247:DNA; D000547:Amantadine