The influence of cysteine on the reaction of d-guanosine with cis-diamminedichloroplatinum (II).
Mono- and bifunctional complexes of cis DDP and d-guanosine were isolated on Sephadex G-25. The presence of cysteine in incubation mixture resulted in the vanishing of bifunctional complex of d-guanosine and the appearance of d-guanosine-cis DDP-cysteine complex in the eluted peak. It is also possible that the eluted peak contained no homogeneous product of the reaction.
D055598:Chemical Phenomena; D002621:Chemistry; D002850:Chromatography, Gel; D002945:Cisplatin; D003545:Cysteine / Q000494:pharmacology*; D003849:Deoxyguanosine; D013056:Spectrophotometry, Ultraviolet
D003849:Deoxyguanosine; D003545:Cysteine; D002945:Cisplatin