Chronic stress enhances apomorphine-induced stereotyped behavior in mice: involvement of endogenous opioids.
Mice subjected to repeated stressful experiences showed an increase in stereotypic climbing behavior induced by apomorphine thus suggesting a modified sensitivity of dopaminergic receptors. Naltrexone, injected before each stressful experience, reversed this effect of chronic stress indicating an involvement of endogenous opioids.
D000818:Animals; D001058:Apomorphine; D004723:Endorphins / Q000502:physiology*; D006801:Humans; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009271:Naltrexone; D011954:Receptors, Dopamine / Q000502:physiology; D013239:Stereotyped Behavior / Q000502:physiology*; D013312:Stress, Physiological / Q000503:physiopathology*
D004723:Endorphins; D011954:Receptors, Dopamine; D009271:Naltrexone; D001058:Apomorphine