Response to ultraviolet radiation: ear swelling in hairless mice.
Ear swelling, as measured by an engineer's micrometer, shows a positive relationship to doses of ultraviolet radiation (over a range of 0 to 7.4 times the minimally damaging dose) during the first 4 d after irradiation. Subsequently, doses greater than 3 D (see text) caused significant thickening associated with scab formation. Doses of 3 D and lower continued to show a well-correlated dose-response to the end of the study. Changes in ear thickness afford a metric indication (non-invasively and repetitively) of the severity of a skin response to UV.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D004423:Ear / Q000473:pathology; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D012867:Skin / Q000528:radiation effects*; D014466:Ultraviolet Rays / Q000009:adverse effects*