title: Synthesis of new 2-(2-phenylethenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-7-carboxylic acids.
abstract: New 2-(2-phenylethenyl)-4-oxo-4H-pyrido[1,2-a]pyrimidine-7-carboxylic acids with a hydroxy or alkoxy substituent in the 3-position were synthesized as potential antiallergic agents. None of them was effective in passive cutaneous anaphylactic reaction test in the rat.
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006633:Histamine Antagonists / Q000138:chemical synthesis*; D007073:Immunoglobulin E / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
chemical_list: D006633:Histamine Antagonists; D011725:Pyridines; D011743:Pyrimidines; D007073:Immunoglobulin E