Esterase-26 (ES-26): characterization and genetic location on chromosome 3 of an eserine-sensitive esterase of the house mouse (Mus musculus).
Genetic variation of a codominantly inherited esterase, designated ES-26, has been discovered in the house mouse using isoelectric focusing in polyacrylamide gels. The ES-26A phenotype (pI 8.2) was found in C57BL/10Sn. A/J showed the ES-26B phenotype (pI 7.8-7.9). A third phenotype, ES-26C (double-banded: pI's 8.1 and 8.3), was observed in SJL/J. ES-26 was detected only in liver, stomach, and small intestine. The enzyme was shown to be controlled by the presumed structural locus Es-26, located on chromosome 3. From a four-point cross, the gene order Car-2--6.2 +/- 2.7--Es-16--21.0 +/- 4.5--Es-26--13.6 +/- 3.8--Amy-1 was established.
D000818:Animals; D002874:Chromosome Mapping; D004591:Electrophoresis, Polyacrylamide Gel; D004950:Esterases / Q000235:genetics*; D014644:Genetic Variation; D007421:Intestine, Small / Q000201:enzymology; D007525:Isoelectric Focusing; D008099:Liver / Q000201:enzymology; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D010641:Phenotype; D010830:Physostigmine / Q000494:pharmacology; D013270:Stomach / Q000201:enzymology
D010830:Physostigmine; D004950:Esterases