Gas chromatographic analysis of cetiedil, a candidate antisickling agent, in human plasma with nitrogen-sensitive detection.
In this report a sensitive gas chromatographic assay for cetiedil, a candidate antisickling agent, in human plasma is described. After a triple extraction procedure, cetiedil was analyzed without derivatization with a nitrogen-phosphorus detector (with papaverine used as the internal standard.) Cetiedil was measured in plasma samples taken from human volunteers administered the drug intravenously.
D000328:Adult; D000986:Antisickling Agents / Q000097:blood*; D001381:Azepines / Q000097:blood*; D002021:Buffers; D002849:Chromatography, Gas; D006801:Humans; D007700:Kinetics; D008297:Male; D009584:Nitrogen
D000986:Antisickling Agents; D001381:Azepines; D002021:Buffers; C006955:cetiedil; D009584:Nitrogen