Alteration of convulsive threshold and conditioned avoidance response in mice fed diets containing contraceptive steroids.
Female CD1 mice given the contraceptive steroids mestranol and norethynodrel (1:10) in the diet (0.0033%) for 4 months had a growth reduction of 20% when compared with mice fed a normal diet, and had lower convulsive thresholds when tested with the vitamin B6 antagonists 2,4-dimethyl-5-methyl-hydroxypyrimidine and thiosemicarbazide. In conditioned avoidance response (CAR) tests, mice fed the steroid-containing diets showed a decreased acquisition performance during all six sessions; however, mice fed the same diet supplemented with vitamin B6 (0.04%) performed as well during the last three sessions of the CAR tests as mice fed the normal diet.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003276:Contraceptives, Oral / Q000633:toxicity*; D003278:Contraceptives, Oral, Hormonal / Q000633:toxicity*; D004032:Diet; D005260:Female; D008656:Mestranol / Q000633:toxicity; D051379:Mice; D009641:Norethynodrel / Q000633:toxicity; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D011736:Pyridoxine / Q000494:pharmacology; D012640:Seizures / Q000503:physiopathology*
D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D009641:Norethynodrel; D008656:Mestranol; D011736:Pyridoxine; D010433:Pentylenetetrazole