Aortic recognition sites for serotonin (5HT) are coupled to phospholipase C and modulate phosphatidylinositol turnover.
The 5HT-mediated contraction of rat thoracic aorta is competitively blocked by the specific receptor antagonist 5HT2 ketanserin. In this tissue the addition of 5HT activated the turnover of 3H-phosphatidylinositol in a ketanserin-reversible fashion. These 5HT2 recognition sites appear to be coupled to a phospholipase C mediated cleavage of phosphatidylinositol.
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000502:physiology*; D006868:Hydrolysis; D007650:Ketanserin; D008297:Male; D010716:Phosphatidylinositols / Q000378:metabolism*; D010740:Phospholipases / Q000378:metabolism*; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D011985:Receptors, Serotonin / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism*; D010738:Type C Phospholipases / Q000378:metabolism*; D014661:Vasoconstriction
D010716:Phosphatidylinositols; D010880:Piperidines; D011985:Receptors, Serotonin; D012701:Serotonin; D007650:Ketanserin; D010740:Phospholipases; D010738:Type C Phospholipases