Pharmacokinetics of zinc tannate after intratesticular injection.
Forty-eight sexually mature male rats were injected intratesticularly with either 1, 3, or 6 mg zinc tannate (Kastrin) or with saline (as control). Zinc localized only in low concentration in primary spermatocytes and could not be detected in spermatogonia, Sertoli cells, spermatids, or spermatozoa. Forty-eight hours after injection of 1 mg Kastrin, zinc was accumulated in the spermatogonia and primary spermatocytes while, after injection of 3 mg, zinc was preferentially localized in Sertoli cells and spermatids; however, zinc was observed in the spermatids and spermatozoa 48 h after injection with 6 mg, and germ cells lost their identity and were fragmented after 1 week.
D000818:Animals; D047348:Hydrolyzable Tannins; D007700:Kinetics; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012671:Seminiferous Tubules / Q000166:cytology / Q000187:drug effects; D013087:Spermatids / Q000166:cytology / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013094:Spermatozoa / Q000166:cytology / Q000187:drug effects; D013634:Tannins / Q000008:administration & dosage / Q000378:metabolism*; D013737:Testis / Q000378:metabolism*
D047348:Hydrolyzable Tannins; D013634:Tannins; C036335:kastrin