Acceleration of peritoneal solute transport by cytochalasin D.
Because cytochalasin D affects intercellular junctions the effect of this agent on peritoneal transport was investigated in normal rabbits. Using commercially available dialysis solution, short-term control peritoneal dialyses were compared in the same animals to dialyses in which cytochalasin D was added intraperitoneally. A dose (325-920 micrograms/kg) dependent increase in peritoneal clearances of urea (49% increment at high dose) and of creatinine (67% increment) occurred when cytochalasin D was added. When solute transport was highest at the maximal dose, osmotically induced ultrafiltration decreased significantly to 33% of control values. Cytochalasin D induces aberrations in solute transport that resemble those accompanying and occasionally following peritonitis.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003404:Creatinine / Q000378:metabolism; D015638:Cytochalasin D; D003572:Cytochalasins / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D010530:Peritoneal Dialysis / Q000379:methods*; D011817:Rabbits; D014508:Urea / Q000378:metabolism; D014882:Water-Electrolyte Balance / Q000187:drug effects
D003572:Cytochalasins; D015638:Cytochalasin D; D014508:Urea; D003404:Creatinine