Influence of methyldopa and bromocriptine on negative pressure breathing-induced diuresis.
The effects of methyldopa, a central alpha 2-agonist, and bromocriptine, a dopaminergic drug, on negative pressure breathing-induced diuresis were studied in the dog. Methyldopa (20 mg/kg i.v. during 20 min) or bromocriptine (0.3 mg/kg i.v.) suppressed the diuretic reflex without changing blood pressure. Since negative pressure breathing-induced diuresis is mainly due to an inhibition of vasopressin secretion, it is suggested that central alpha 2-adrenoceptors and dopaminergic receptors play an inhibitory role in mediating vasopressin release to non osmotic stimuli.
D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects*; D004285:Dogs; D005260:Female; D008297:Male; D008750:Methyldopa / Q000494:pharmacology*; D012121:Respiration, Artificial
D001971:Bromocriptine; D008750:Methyldopa