title: [Changes in the biological properties of influenza virus (HON1) strains virulent for mice when exposed to homologous antibodies].
abstract: A decrease in the virulent properties of two influenza virus strains (A/PR/8/34 and A/Mel/35 (HON1) pathogenic for mice was demonstrated in multiple passages in chick embryos in the presence of homologous antibody. The artificially developed avirulent A/PR/8/240 and A/Mel/375 variants had low immunogenic activity and a marked temperature sensitivity to 40 degrees C. Common ts mutations in the genomes of these avirulent variants located in genes 1 and 7 coding for P3 and M proteins were demonstrated.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D000956:Antigens, Viral / Q000276:immunology; D002642:Chick Embryo; D006224:Cricetinae; D005814:Genes, Viral; D007114:Immunization; D009980:Influenza A virus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D051379:Mice; D009154:Mutation; D011817:Rabbits; D051381:Rats; D013696:Temperature; D014774:Virulence; D014779:Virus Replication
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral
vernacular_title: Izmeneniia biologicheskikh svoĭstv virulentnykh dlia mysheĭ shtammov virusa grippa (HON1) pod vozdeĭstviem gomologichnykh antitel.