Cancer precursors and their control by stimulation of the immune system.
BCG vaccination at birth according to our studies and those from Montreal, Austria, and Israel, lowers the mortality from leukemia and, in my studies, to all forms of cancer followed over a period of 20 years. It has been proposed by several studies that the lymphoreticulo-endothelial system detects and destroys neoantigens such as would be the case in remnant embryonic antigens. It follows that stimulation of the immune system would be desirable at birth to augment the removal of such neoantigens. There are numerous vaccines which stimulate the immune system, and BCG is among the foremost. I propose, therefore, that the mechanism of cancer mortality reduction in those BCG vaccinated at birth was at least in part due to the detection and destruction of embryonic cells or components thereof. To prove this theory, I recommend: Retrospective studies be done in those BCG vaccinated at birth and those not vaccinated for the incidence of cancer and leukemia over the years. Test cells, sera, and urine of those BCG vaccinated and non-vaccinated for the presence of embryonic antigens or antibodies. BCG vaccinated individuals should have lower titers of fetal antigens or antibodies than the non-vaccinated. Examine the organs on post mortem of BCG vaccinated and non-vaccinated individuals who died from trauma for the presence of fetal antigens or antibodies.
D000293:Adolescent; D000328:Adult; D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis; D001500:BCG Vaccine / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D005326:Fetal Proteins / Q000276:immunology; D005333:Fetus / Q000276:immunology; D006168:Guinea Pigs; D006801:Humans; D007107:Immune System / Q000502:physiology*; D007114:Immunization; D007223:Infant; D007231:Infant, Newborn; D007938:Leukemia / Q000401:mortality; D008208:Lymphatic System / Q000502:physiology; D012157:Mononuclear Phagocyte System / Q000502:physiology; D009369:Neoplasms / Q000276:immunology / Q000517:prevention & control*; D009857:Oncogenes; D010587:Phagocytosis
D000951:Antigens, Neoplasm; D001500:BCG Vaccine; D005326:Fetal Proteins