title: Microbial contamination of a vitamin A formulation, prepared in local pharmacies, and its preservation against yeasts and moulds.
abstract: The microbial contamination of 44 samples of a vitamin A preparation in sucrose syrup was investigated. The contaminants were almost exclusively yeasts and moulds. Microbiological and physicochemical studies showed that sorbic acid was the preservative of choice for this formulation. The results are discussed with respect to the preservation of non-sterile pharmaceuticals.
mesh_terms: D004340:Drug Contamination / Q000517:prevention & control*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects / Q000302:isolation & purification; D009426:Netherlands; D010592:Pharmaceutic Aids / Q000592:standards*; D011136:Polysorbates / Q000378:metabolism / Q000494:pharmacology; D011310:Preservatives, Pharmaceutical / Q000494:pharmacology / Q000592:standards*; D013011:Sorbic Acid / Q000378:metabolism / Q000494:pharmacology; D014801:Vitamin A / Q000592:standards*
chemical_list: D005231:Fatty Acids, Unsaturated; D010592:Pharmaceutic Aids; D011136:Polysorbates; D011310:Preservatives, Pharmaceutical; D014801:Vitamin A; D013011:Sorbic Acid