[Effect of synthetic regulators of radical reactions on the course of experimental silicosis].
Therapeutic properties of N-oxide poly-1,2-ethylene piperidine (NO-PEP) as well as of free radical reaction inhibitors, bound with polymers by means of complex and covalent linkages, were studied in experimental silicosis. The preparations studied were used depending on the step of silicosis development as well as on the type of impairment in lipid peroxidation and the antioxidative activity (AOA) of lung lipids. The data obtained are discussed in relation to properties of the preparations used and to alterations in lipid peroxidation and AOA reactions found in silicosis. Use of immobilized physiologically active substances enabled to establish some principles in development of antisilicosis drugs.
D000818:Animals; D005453:Fluorescence; D005609:Free Radicals; D008054:Lipid Peroxides / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D008297:Male; D010880:Piperidines / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains; D012829:Silicosis / Q000188:drug therapy / Q000378:metabolism*; D013997:Time Factors
D005609:Free Radicals; D008054:Lipid Peroxides; D010880:Piperidines; C044413:poly(1,2-ethylenepiperidine) N-oxide
Vliianie sinteticheskikh reguliatorov radikal'nykh reaktsiĭ na techenie éksperimental'nogo silikoza.