Biosynthesis of the bufadienolide ring of scillirosid in Scilla maritima.
Administration of sodium [1,2-14C2]oxaloacetate and sodium [1-14C]acetate to Scilla maritima plants yielded labelled scillirosid. A systematic degradation of scillirosid indicated that the alpha-pyrone ring of the bufadienolide is formed by the condensation of a pregnane derivative (derived from mevalonic acid via squalene) and one molecule of oxaloacetic acid.
D000085:Acetates / Q000378:metabolism; D019342:Acetic Acid; D002018:Bufanolides / Q000096:biosynthesis*; D002250:Carbon Radioisotopes; D055598:Chemical Phenomena; D002621:Chemistry; D010071:Oxaloacetates / Q000378:metabolism; D010946:Plants, Medicinal / Q000378:metabolism*; D012378:Rodenticides
D000085:Acetates; D002018:Bufanolides; D002250:Carbon Radioisotopes; D010071:Oxaloacetates; D012378:Rodenticides; C022879:scilliroside; D019342:Acetic Acid