[Effect of the synthetic antioxidants ionol and dibunol on hemorrhagic ulcerative lesions of the stomach in rats].
Comparative studies made on 79 male rats indicate that the synthetic antioxidants ionol and dibunol liniment administered intragastrically in a dose of 50 mg/kg for 7 days do not exert any protective effect on gastric mucosa lesions caused by ligation of the pylorus by Shay's method. At the same time the antioxidants had an inhibitory effect on activation of lipid peroxidation in gastric tissues of rats operated on according to Shay. The absence of the protective action of the antioxidants on ulcer formation together with an inhibitory effect on activation of lipid peroxidation in gastric tissues provide no evidence in favor of the leading role of lipid peroxidation during gastric lesion in animals with ligated pylorus.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010438:Peptic Ulcer Hemorrhage / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D013276:Stomach Ulcer / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism
D000975:Antioxidants; D008054:Lipid Peroxides; D002084:Butylated Hydroxytoluene
Vliianie sinteticheskikh antioksidantov ionola i dibunola na gemorragicheski-iazvennye porazheniia zheludka u krys.