[Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects. (2). Protective effect of latamoxef against gentamicin nephrotoxicity].
Effects of gentamicin (GM) alone and in combination with latamoxef (LMOX), an oxacefem antibiotic, were studied in rat kidney in order to determine the effect of combinations of nephrotoxic drugs. Groups of 7 male Sprague-Dawley rats, weighing approx. 230 g, were given daily s.c. doses of GM (80 mg/kg) or 80 mg/kg GM plus LMOX (500, 1000 or 2000 mg/kg) for 15 days. Treatment with GM alone resulted in marked increases in urinary lactate dehydrogenase, N-acetyl-beta-glucosaminidase and lysozyme activities, urinary protein contents and blood urea nitrogen contents, which peaked on the 10th day. The combination of GM plus LMOX significantly suppressed the increases in these biochemical parameters with GM alone. In this case, the suppressions were roughly dependent on the dose of LMOX. Although GM alone caused pronounced histological changes in proximal tubules between the 7th and 15th days, the combination with LMOX apparently protected against these changes. These results indicate that the combination with LMOX obviously protects the kidney from the nephrotoxicity of GM.
D000118:Acetylglucosaminidase / Q000652:urine; D058186:Acute Kidney Injury / Q000517:prevention & control*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001806:Blood Urea Nitrogen; D005839:Gentamicins / Q000037:antagonists & inhibitors*; D007668:Kidney / Q000473:pathology; D007683:Kidney Tubular Necrosis, Acute / Q000175:diagnosis / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D009070:Moxalactam / Q000627:therapeutic use*; D011507:Proteinuria / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D000118:Acetylglucosaminidase; D009070:Moxalactam