title: Primary hemangiosarcoma of the spleen with angioscintigraphic demonstration of metastases.
abstract: A case of primary hemangiosarcoma of the spleen in a 48-year-old woman is presented. Twenty-eight months after splenectomy the patient developed a severe anemia of the microangiopathic type, thrombocytopenia, and a leukoerythroblastic peripheral blood picture. In contrast to x-ray and conventional 99mTc-methylene-diphosphonate (MDP) bone scintigraphy, which showed only a few minor focal changes in the spine and ribs, angioscintigraphy with in vitro labeled 99mTc-erythrocytes revealed extensive pathologic accumulations throughout the spine, femurs, and the liver, indicating the presence of extremely vascular metastases. Autopsy 15 months later confirmed the scintigraphic findings. Angiography with 99mTc-labeled erythrocytes seems to be useful for monitoring metastases from hemangiosarcomas.
mesh_terms: D000740:Anemia / Q000209:etiology; D001853:Bone Marrow / Q000473:pathology; D001859:Bone Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging / Q000556:secondary*; D004912:Erythrocytes; D005260:Female; D006394:Hemangiosarcoma / Q000000981:diagnostic imaging*; D006801:Humans; D008113:Liver Neoplasms / Q000098:blood supply / Q000000981:diagnostic imaging / Q000556:secondary*; D008833:Microcirculation; D008875:Middle Aged; D011877:Radionuclide Imaging; D013156:Splenectomy / Q000009:adverse effects; D013160:Splenic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D013667:Technetium
chemical_list: D013667:Technetium