A third example of haemolytic auto-anti-Vel.
A non-transfused, 43 year old Caucasian female presented with acute haemolytic anaemia and splenomegaly. Sections of bone marrow showed erythroid hyperplasia. The patient's red blood cells gave a negative reaction with polyspecific antiglobulin serum, but a positive reaction with specific anti-IgM. A heat eluate prepared from her red cells showed anti-Vel specificity. Her serum agglutinated only Vel-positive cells including her own. All papain pre-treated red cells including her own and Vel-negative cells were completely haemolysed at 37 degrees C. The percentage of haemolysis of Vel-positive cells was greater than that of Vel-negative cells.
D000328:Adult; D000743:Anemia, Hemolytic / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006386:Hemagglutination Tests; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology; D010206:Papain / Q000378:metabolism
D001323:Autoantibodies; D007075:Immunoglobulin M; D010206:Papain