title: [Treatment of diffuse membranous glomerulonephritis with a combination of anticoagulants and corticosteroids].
abstract: The results are reported from the administration of an original therapeutic combination, including anticoagulants (heparin and acenocoumarol) and corticosteroids to 18 patients with diffuse membranous glomerulonephritis. The anticoagulant treatment begins with heparin intravenously (30 000 U daily) and continues, after 1-2 months with acenocoumarol. The corticosteroids were applied with an initial dose of 60 mg prednison, with further gradual decrease. The treatment lasts from 7 to 60 months (18,8 months on the average). Complete clinical-laboratory remission was obtained in 14 patients (77,8%), and partial in 3 (16,7%). The remission develops 6 to 24 months (8,7 months on the average) after the initiation of the treatment. According to the author, the good therapeutic results are due to the original combination of anticoagulants with corticosteroids, not administered so far by other authors to membranous glomerulonephritis, to the rather long-term treatment and to the qualitative follow-up care.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use*; D001485:Basement Membrane / Q000276:immunology; D002908:Chronic Disease; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D000305:Adrenal Cortex Hormones; D000925:Anticoagulants; D007136:Immunoglobulins
vernacular_title: Lechenie na difuznite membranozni glomerulonefriti s kombiniatsiia ot antikoagulanti i kortikosteroidi.