DNA damage induced by asbestos in the presence of hydrogen peroxide.
Treatment of calf thymus DNA with various types of asbestos fibers in the presence of hydrogen peroxide under physiological conditions (pH 7.4, 37 degrees) resulted in the hydroxylation of the C-8 position of guanine residues. DNA strand scission was also detected after these treatments.
D000818:Animals; D001194:Asbestos / Q000633:toxicity*; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D004247:DNA; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D006900:Hydroxylation; D013329:Structure-Activity Relationship; D013950:Thymus Gland
D001194:Asbestos; D004247:DNA; D006861:Hydrogen Peroxide