Fatty acyl-coenzyme A oxidase activity and H2O2 production in Phanerochaete chrysosporium mycelia.
Mycelia of the lignin-degrading fungus Phanerochaete chrysosporium consume O2 and produce extracellular H2O2 when incubated with fatty acyl-CoA substrates, even in the presence of mitochondrial respiratory chain inhibitors such as antimycin A and cyanide. These results suggest the possibility that peroxisomal fatty acyl-CoA oxidase activity in P. chrysosporium mycelia may be an important metabolic source for the extracellular H2O2 believed to be involved in lignin biodegradation.
D042962:Acyl-CoA Oxidase; D000363:Agaricales / Q000201:enzymology*; D006861:Hydrogen Peroxide / Q000378:metabolism*; D007700:Kinetics; D008830:Microbodies / Q000201:enzymology; D008928:Mitochondria / Q000201:enzymology; D010088:Oxidoreductases / Q000378:metabolism*; D013379:Substrate Specificity
D006861:Hydrogen Peroxide; D010088:Oxidoreductases; D042962:Acyl-CoA Oxidase