Rat liver DNA damage by the non-hepatocarcinogen 3,2'-dimethyl-4-aminobiphenyl.
The intestinal carcinogen 3,2'-dimethyl-4-aminobiphenyl (DMAB) and the hepatocarcinogen N-2-acetylaminofluorene (AAF) were administered intraperitoneally to male F344 rats to determine if both would produce DNA damage in the liver. Hepatocyte primary cultures (HPC) were prepared and DNA-repair was assessed in vitro by autoradiography. Hepatocytes from both DMAB- and AAF-exposed rats displayed DNA repair synthesis. These results confirm other observations that non-hepatocarcinogens can produce DNA damage in the liver, and that they can be detected in both in vitro and in vivo HPC/DNA repair assays.
D015073:2-Acetylaminofluorene / Q000633:toxicity; D000611:Aminobiphenyl Compounds; D000814:Aniline Compounds / Q000633:toxicity*; D000818:Animals; D001345:Autoradiography; D002273:Carcinogens; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D004247:DNA / Q000378:metabolism*; D004260:DNA Repair; D004121:Dimethyl Sulfoxide / Q000633:toxicity; D004159:Diphenylamine / Q000031:analogs & derivatives / Q000633:toxicity*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
D000611:Aminobiphenyl Compounds; D000814:Aniline Compounds; D002273:Carcinogens; C001042:2',3-dimethyl-4-aminobiphenyl; D004247:DNA; D015073:2-Acetylaminofluorene; D004159:Diphenylamine; D004121:Dimethyl Sulfoxide