[Changes in the arterial pressure and evoked potential in the sensorimotor cortex induced by nalorphine injected in the hypothalamus during painful electric shock in rabbits].
During the hypotensive phase of electronocuous shock in rabbits, injection of nalorphine to the hypothalamus provoked elevation in the blood pressure (BP), recovery of the evoked potential (EP) of the sensorimotor brain cortex in response to electrodermal stimulation (EDS) of the hind limb. Injection of the drug to the central gray of the midbrain resulted in an insignificant short-term elevation of the BP followed by its drop. It is concluded that the endogenous opioid system of the hypothalamus is of importance in the genesis of the hypotensive response and suppression of the EP of the rabbit sensorimotor brain cortex in response to EDS during electronocuous shock.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D006801:Humans; D007031:Hypothalamus / Q000187:drug effects*; D007267:Injections; D009269:Nalorphine / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D013315:Stress, Psychological / Q000503:physiopathology*
D009269:Nalorphine
Izmenenie arterial'nogo davleniia i vyzvannogo potentsiala sensomotornoĭ kory golovnogo mozga pod vliianiem nalorfina, vvedennogo v gipotalamus pri élektrobolevom shoke u krolikov.