title: Synthesis and cytotoxic activity of estrogen alpha-methylene-delta-lactones.
abstract: Several estrogen derivatives containing the alpha-methylene-delta-lactone group as part of the D-ring were prepared as anti-tumor agents. The compounds were highly toxic towards HeLa S3 cells grown in culture.
mesh_terms: D002470:Cell Survival / Q000187:drug effects; D045166:Estradiol Congeners / Q000138:chemical synthesis* / Q000633:toxicity; D006367:HeLa Cells / Q000166:cytology / Q000187:drug effects; D006801:Humans; D007202:Indicators and Reagents; D007700:Kinetics; D007783:Lactones / Q000138:chemical synthesis* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013053:Spectrophotometry; D013329:Structure-Activity Relationship
chemical_list: D045166:Estradiol Congeners; D007202:Indicators and Reagents; D007783:Lactones