Dose-independence of early, cyclophosphamide-induced lung damage in mice.
Administration of cyclophosphamide to mice resulted in lung damage which was assessed by measuring breathing rate and lung compliance. Above a threshold dose (approximately 50-100 mg/kg b.w.) the time of onset and severity of early, acute pulmonary dysfunction was dose-independent in the range 100-400 mg/kg. At doses up to 200 mg/kg lung damage was reversible but above this second threshold level, pulmonary fibrosis invariably developed. The severity of late damage (approximately day 40) was dose-related. These findings may help in the interpretation of clinical lung damage associated with cyclophosphamide therapy.
D000818:Animals; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D006985:Hyperventilation / Q000139:chemically induced; D008168:Lung / Q000187:drug effects*; D008170:Lung Compliance; D008171:Lung Diseases / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011658:Pulmonary Fibrosis / Q000139:chemically induced
D003520:Cyclophosphamide