Degradative behavior of cadralazine in aqueous solution.
The degradation of cadralazine in aqueous solution was investigated in relation to pH, concentration, and temperature, under aerobic and anaerobic conditions in light and dark. The appearance of three main degradation products was also studied. Drug disappearance was dependent on temperature, pH, concentration, and oxygen and followed three different mechanistic pathways: thermal, hydrolytic, and oxidative. The individual rate constants were determined by nonlinear regression fitting.
D000388:Air; D002626:Chemistry, Pharmaceutical; D006863:Hydrogen-Ion Concentration; D008027:Light; D011724:Pyridazines / Q000032:analysis*; D012996:Solutions; D013696:Temperature
D011724:Pyridazines; D012996:Solutions; C031877:cadralazine