title: Changes in functional ceruloplasmin concentrations of plasma and exudate and the effect of exogenous ceruloplasmin on the carrageenin-induced inflammation in rats.
abstract: Changes in functional ceruloplasmin (Cp) concentrations of plasma and exudate during acute and chronic inflammatory processes were studied in detail by measuring Cp oxidase activity in the carrageenin-induced inflammation in rats. In contrast with the plasma functional Cp level as an acute-phase reactant, the exudate functional Cp level was very low during the acute phase, increased in the chronic phase and reached a constant value which was only half value of the plasma functional Cp level. The locally injected Cp had no effect on the carrageenin-induced inflammation, suggesting that exogenous Cp has no anti-inflammatory effect on the inflamed rats eating normal diet.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D002351:Carrageenan; D002570:Ceruloplasmin / Q000378:metabolism* / Q000494:pharmacology; D005122:Exudates and Transudates / Q000378:metabolism*; D007249:Inflammation / Q000139:chemically induced*; D008297:Male; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D000893:Anti-Inflammatory Agents; D002351:Carrageenan; D002570:Ceruloplasmin; C019052:ceruloplasmin amine oxidase; D000587:Oxidoreductases Acting on CH-NH Group Donors