Hematologic data of selenium-deficient and selenium-supplemented rats.
Effect of dietary selenium as sodium selenite on in vivo hematological parameters of Sprague-Dawley rats was examined over a 7-month period. Dietary selenium did not alter total hemoglobin, hematocrits, erythrocyte counts, or the osmotic fragility pattern of rat blood. Selenium-excessive (1.0 ppm) rats showed slightly lower but not significantly lower methemoglobin levels than selenium-adequate (0.1 ppm) or selenium-deficient rats. Platelet counts tended to be higher in selenium-excessive rats and lower in selenium-deficient rats than in selenium-adequate rats, but the differences were not statistically significant. No clear trends were observed regarding the effect of dietary selenium on total leukocyte and differential leukocyte counts. After 7 months of dietary treatment blood glutathione peroxidase activity in selenium-deficient rats and in selenium-excessive rats was 16.8% and 142.2% of the activity in selenium-adequate rats. The results indicate that long-term selenium deficiency in rats produces no abnormal hematological parameters or any compensated hemolytic anemia in vivo.
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D007958:Leukocyte Count; D007962:Leukocytes / Q000187:drug effects; D008706:Methemoglobin / Q000378:metabolism; D010976:Platelet Count; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium / Q000172:deficiency* / Q000494:pharmacology
D008706:Methemoglobin; D005979:Glutathione Peroxidase; D012643:Selenium