[Pharmacokinetics of nitrofurantoin in the bodies of pregnant rats].
The investigation of nitrofurantoin (NTF) pharmacokinetics in pregnant rats was undertaken to estimate its cumulation in the fetus unit. It was found that pharmacokinetics of NTF is dose-dependent in non-pregnant rats. The biological half-life time increased from 0.24 to 0.41 and 0.72 h for NTF doses 10.20 and 40 mg/kg, respectively. The elimination of NTF was diminished in pregnant rats. The pharmacokinetic analysis revealed a possibility of strong NTF accumulation in the pregnant rats (increased K12/K21 ratio). Taking into account increased renal function in pregnancy, one may suspect that decreased elimination of NTF was rather caused by its significant cumulation in the changed tissue compartment.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006207:Half-Life; D007275:Injections, Intravenous; D007700:Kinetics; D008657:Metabolic Clearance Rate; D009582:Nitrofurantoin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D009582:Nitrofurantoin
Farmakokinetyka nitrofurantoiny (NTF) w ustroju szczurów ciezarnych.