Oxidised glutathione reductase activity in mouse epidermis: TPA induced change and its modulation by vitamin A.
Single cutaneous application of 12-O-tetradecanoyl-phorbol-13-acetate (TPA) increased epidermal oxidised glutathione reductase activity in adult mouse by almost 100%. Pretreatment of animals with vitamin A for a week resulted in 75% inhibition of TPA induced change in the enzyme activity which remained unaffected in skin treated with vitamin A alone. This biochemical change in skin induced by TPA and modulated by vitamin A has been discussed in relation to epidermal hyperplasia.
D000818:Animals; D004817:Epidermis / Q000201:enzymology*; D005260:Female; D005980:Glutathione Reductase / Q000378:metabolism*; D051379:Mice; D008954:Models, Biological; D009249:NADP / Q000378:metabolism; D010704:Phorbols / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D014801:Vitamin A / Q000494:pharmacology*
D010704:Phorbols; D014801:Vitamin A; D009249:NADP; D005980:Glutathione Reductase; D013755:Tetradecanoylphorbol Acetate