Urinary excretion of digoxin and its metabolites in hyperacidic patients and in patients during coronary care.
The hydrolytic cleavage of digoxin was studied after single oral doses of tritiated glycoside to four patients with gastric hyperacidity (GH-group) and to six patients during coronary care (CCU-group). Drug analysis was performed with a high-pressure liquid chromatographic method. Results in the two groups did not differ and were similar to results in a previous study in healthy volunteers. On the average 22% of the radioactivity was recovered in 24-h urine specimen. Of this 24.8 +/- 8.5% (GH-group, mean +/- SEM) and 19.3 +/- 6.6% (CCU-group) were cleavage products and unidentified, polar metabolites in equal amounts. This indicates that hydrolysis of digoxin is on average limited even in patients at risk for such metabolic cleavage.
D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000652:urine*; D004077:Digoxin / Q000652:urine*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged
D004077:Digoxin