The effects of pretreatment with stomach extract on the incidence of X-ray-induced gastric tumor in ICR mice.
The effect of crude stomach extracts (CSE) on X-ray-induced gastric tumorigenesis was examined. ICR mice were treated with two or four administrations of CSE at one-week intervals then irradiated with 20 Gy of X-rays one week after the final CSE administration. Unexpectedly, the incidence of X-ray-induced tumors was not significantly altered by two CSE pretreatments but was markedly reduced by four CSE pretreatments. Similarly, erosion and squamous metaplasia produced in the glandular stomach a week after X-irradiation were markedly diminished by four CSE pretreatments but not by two CSE pretreatments.
D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D006965:Hyperplasia; D051379:Mice; D008813:Mice, Inbred ICR; D008815:Mice, Inbred Strains; D009381:Neoplasms, Radiation-Induced / Q000473:pathology*; D013270:Stomach / Q000473:pathology / Q000502:physiology*; D013274:Stomach Neoplasms / Q000473:pathology*; D013997:Time Factors; D014020:Tissue Extracts / Q000494:pharmacology*
D014020:Tissue Extracts