[Experience in combination therapy with amikacin and cephapirin for infections complicated with acute leukemia during induction chemotherapy].
We treated infections accompanied with induction chemotherapy in 9 patients with acute leukemia by the combination of amikacin (AMK) and cephapirin (CEPR). The result was that 1 case was markedly effective, 2 cases were effective, 3 cases were marginally effective, 2 cases showed no effect and 1 case who underwent prophylactic medication had no infection. We recognized no adverse effects by AMK or CEPR. We concluded that the combination of AMK and CEPR was useful as first choice to the treatment of infections during induction chemotherapy of acute leukemia.
D000208:Acute Disease; D000328:Adult; D000583:Amikacin / Q000008:administration & dosage*; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000188:drug therapy* / Q000209:etiology; D002511:Cephalosporins / Q000008:administration & dosage*; D002514:Cephapirin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007612:Kanamycin / Q000031:analogs & derivatives*; D007938:Leukemia / Q000150:complications* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged
D000970:Antineoplastic Agents; D002511:Cephalosporins; D007612:Kanamycin; D000583:Amikacin; D002514:Cephapirin