Angiosarcomas in hamsters after inoculation of brain tissue from a case of progressive multifocal leukoencephalopathy.
Subcutaneous inoculation of minced brain tissue from a case of progressive multifocal leukoencephalopathy into newborn Syrian hamsters produced transplantable angiosarcomas in 2 of 11 animals. Immunostaining revealed the presence of SV40 in the progressive multifocal leukoencephalopathy (PML) tissue, indicating this virus as the tumor-inducing agent.
D000368:Aged; D000818:Animals; D000831:Animals, Newborn; D001921:Brain; D006224:Cricetinae; D006394:Hemangiosarcoma / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D007968:Leukoencephalopathy, Progressive Multifocal / Q000473:pathology*; D008297:Male; D008647:Mesocricetus; D008854:Microscopy, Electron; D009368:Neoplasm Transplantation; D009417:Nerve Tissue / Q000637:transplantation; D051381:Rats; D011919:Rats, Inbred Strains; D014412:Tumor Virus Infections