Pharmacokinetics of buflomedil after intravenous administration in patients with chronic renal failure.
The pharmacokinetics of single intravenous doses of buflomedil were studied in nine patients with chronic renal failure. The mean buflomedil half-life was 5.38 h (range 1.78-11.8 h); the mean buflomedil total clearance was 11.8 l/h (range 2.67-37.2 l/h). Comparisons of buflomedil kinetic parameters between the uraemic patients and healthy subjects revealed significant decreases in the renal elimination percentage u, the renal clearance Clr; significant increase in elimination half-life from the central compartment and no significant differences in the other parameters. Chronic renal failure is associated with a significant alteration in buflomedil elimination. This study suggests to reduce the usual dosage to half its value in the renal disease.
D000328:Adult; D000368:Aged; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007676:Kidney Failure, Chronic / Q000097:blood / Q000378:metabolism* / Q000652:urine; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011485:Protein Binding / Q000187:drug effects; D011759:Pyrrolidines / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism* / Q000652:urine
D011759:Pyrrolidines; D003404:Creatinine; C010651:buflomedil