Single-dose thiamphenicol for the treatment of gonorrhea.
Acute gonococcal urethritis was treated with a single oral dose of 2.5 g of thiamphenicol in 62 patients after diagnosis by gram-staining of urethral smears and/or cultures for Neisseria gonorrhoeae in Thayer-Martin medium. Therapy resulted in bacteriologic and clinical cure in 50 cases. Three cases were not cured by this treatment. Nine patients failed to return for follow-up examination. The only adverse reaction to treatment was diarrhea in one patient. The taste of the preparation of thiamphenicol administered was considered acceptable by most patients.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013839:Thiamphenicol / Q000008:administration & dosage / Q000627:therapeutic use*; D014526:Urethritis / Q000188:drug therapy* / Q000209:etiology
D013839:Thiamphenicol