Cyclic GABA-GABOB analogues. IV. Activity on learning and memory.
A number of N-substituted 4-hydroxy-, 4-acyloxy- and 4-alkoxy-2-pyrrolidinones were examined by a screening method predictive of their activity on cognitive processes. The 1-aminocarbonylmethyl-substituted compounds showed a favorable effect on learning and memory, and among them the most active was the 4-hydroxy derivative, oxiracetam, which had a potency considerably higher than piracetam, used for comparison purposes.
D000647:Amnesia / Q000517:prevention & control; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004597:Electroshock; D006801:Humans; D007858:Learning / Q000187:drug effects*; D007928:Lethal Dose 50; D008297:Male; D008568:Memory / Q000187:drug effects*; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
C004480:4-amino-3-hydroxybutyric acid; D005680:gamma-Aminobutyric Acid