Screening for new microbial products by high-performance liquid chromatography using a photodiode array detector.
The screening for new microbial metabolites in culture filtrates from Streptomyces tendae TU 901 by high-performance liquid chromatography using a photodiode array detector resulted in detection of new compounds related to the parent compounds. Six peaks in the elution profiles of different strains could be identified as potential new nikkomycins, a group of nucleoside-peptide antibiotics. Structure elucidation confirmed the assumption for new nikkomycin structures.
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003470:Culture Media; D006863:Hydrogen-Ion Concentration; D009705:Nucleosides / Q000032:analysis; D013302:Streptomyces / Q000378:metabolism
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D003470:Culture Media; D009705:Nucleosides; C011952:nikkomycin