title: [Clinical value of determining pepsinogen I].
abstract: The serum values of PG I and gastrin have been established in a normal population and in several clinical diseases. The PG I is raised in duodenal, gastric, and pyloric ulcer even though the gastrin is normal. Both PG I and gastrin values are raised in renal insufficiency and the Zollinger-Ellison syndrome. The PG I is lowered in atrophic gastritis and alcoholic cirrhosis, and is at the limit of detection in Biermer anemia and total gastrectomy. Insulin and sham-feeding are stimulants for PG I release by patients with duodenal ulcer, but no correlation is observed between PG I output and PAO in the studied group. The results show that PG I is able to distinguish between associated hypergastrinemia and hypoacidity (Biermer anemia type) or a hyperacidity (Zollinger-Ellison syndrome type), and that PG I is a good indicator for gastric hypoacidity. Overlapping between normal and ulcer subjects is comparable to those obtained in acid output determinations.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000752:Anemia, Pernicious / Q000097:blood; D004381:Duodenal Ulcer / Q000097:blood; D005260:Female; D005743:Gastrectomy; D005755:Gastrins / Q000097:blood; D005757:Gastritis, Atrophic / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood; D008103:Liver Cirrhosis / Q000097:blood; D008297:Male; D008875:Middle Aged; D010435:Pepsinogens / Q000097:blood*; D012016:Reference Values; D013276:Stomach Ulcer / Q000097:blood; D015043:Zollinger-Ellison Syndrome / Q000097:blood
chemical_list: D005755:Gastrins; D010435:Pepsinogens
vernacular_title: Intérêt clinique du dosage du pepsinogène I.