title: Urine lactic dehydrogenase--an aid in the management of patients with spinal cord injury.
abstract: Urine lactic dehydrogenase (LD) and urinary LD isoenzyme determinations were performed for 59 adult afebrile patients with spinal cord lesions. Twenty-eight were found to have a predominance of LD 1 and 2. Thirteen had positive urine cultures and 12 also had positive antibody coated bacteria (ACB). Twenty were found to have a predominance of LD 4 and 5, with a mean total urine LD activity of 175.7 mU/ml. Sixteen of this group had positive urine cultures and 12 also ACB positive. Eleven had no demonstrable LD isoenzyme with a mean total urine LD activity of 17.5 mU/ml. Eight had positive urine cultures and four were also ACB positive. Forty-six normal controls had a mean LD activity of 15.1 mU/ml. In the study population changes in U-LD occurred in the absence of bacteriuria most frequently in patients who were appliance-free or used catheterization. In the absence of bacteriuria bladder overdistention may contribute to changes in LD isoenzyme patterns.
mesh_terms: D000328:Adult; D006801:Humans; D007527:Isoenzymes; D007674:Kidney Diseases / Q000175:diagnosis; D007770:L-Lactate Dehydrogenase / Q000652:urine*; D013119:Spinal Cord Injuries / Q000201:enzymology* / Q000652:urine; D001745:Urinary Bladder Diseases / Q000175:diagnosis; D014546:Urinary Catheterization
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase