Effects of chronic manganese intake on the levels of biogenic amines in rat brain regions.
After eight months of chronic manganese intake a significant decrease in the concentration of NA in striatum and pons of rats treated with 0.1 mg Mn/ml water was produced. A highly significant decrease in the levels of DOPAC was found in striatum and hypothalamus of rats receiving 0.1 and 1.0 mg Mn/ml water. HVA content diminished in the striatum of the 0.1 mg Mn/ml group. The concentration of 5-HT was reduced in midbrain of rats ingesting 1.0 mg Mn/ml water. 5-HIAA was found to be diminished in hippocampus and pons of the same group of animals and in the hippocampus of the 0.1 mg Mn/ml group. According to our findings serotonergic neurons seem to be less sensitive to manganese poisoning than catecholaminergic neurons.
D000704:Analysis of Variance; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002845:Chromatography; D004032:Diet; D008297:Male; D020149:Manganese Poisoning; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014018:Tissue Distribution
D001679:Biogenic Amines