Influence of decontamination of the digestive tract on the urinary excretion of histamine and some of its metabolites.
Urinary excretions of histamine, N tau-methylhistamine and N tau-methylimidazoleacetic acid have been determined for 8 healthy volunteers during 14 consecutive days. Selective decontamination of the digestive tract was performed from day 3 to day 6, followed by total decontamination from day 7 to day 10. Urinary excretions of N tau-methylhistamine and N tau-methylimidazoleacetic acid decreased to a small though significant degree (about 15-20%) after total decontamination, suggesting a histamine production by anaerobic bacteria. Cadaverine decreased for about 70% under both selective and total decontamination, suggesting that this amine in human urine mainly originates from aerobic bacteria in the intestinal tract.
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D002103:Cadaverine / Q000652:urine; D004064:Digestive System / Q000382:microbiology*; D005243:Feces / Q000382:microbiology; D005260:Female; D006632:Histamine / Q000652:urine*; D006801:Humans; D007093:Imidazoles / Q000652:urine; D007422:Intestines / Q000382:microbiology; D008297:Male; D008761:Methylhistamines / Q000652:urine; D008875:Middle Aged; D013997:Time Factors
D000900:Anti-Bacterial Agents; D007093:Imidazoles; D008761:Methylhistamines; C002667:methylimidazoleacetic acid; C031205:3-methylhistamine; D006632:Histamine; D002103:Cadaverine