The Crow-Fukase syndrome: a study of 102 cases in Japan.
Clinical manifestations of 102 cases with the Crow- Fukase syndrome (the syndrome of polyneuropathy, anasarca, skin changes, endocrinopathy, dysglobulinemia, and organomegaly), with or without myeloma, were reviewed. Fifty-six cases with myeloma consisted of 31 with osteosclerotic, 17 with mixed osteosclerotic and osteolytic, and 8 with osteolytic. Forty-six cases without myeloma consisted of 2 with extramedullary plasmacytoma, 33 with M protein alone, and 11 with polyclonal protein alone. There was no significant difference in incidence of the major clinical manifestations between the two groups with and without myeloma. They had a common characteristic histologic finding of the lymph node resembling that of Castleman's disease.
D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000032:analysis; D001859:Bone Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology*; D005260:Female; D006801:Humans; D007136:Immunoglobulins; D007564:Japan; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009431:Neural Conduction; D010954:Plasmacytoma / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology*; D011115:Polyneuropathies / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D011859:Radiography; D012871:Skin Diseases / Q000097:blood / Q000473:pathology*; D013577:Syndrome
D001798:Blood Proteins; D007136:Immunoglobulins; C009823:M-proteins (Myeloma)