Preliminary pharmacokinetic study of isometamidium chloride in camels.
Isometamidium chloride was given to camels at a single intravenous dose rate of 0.5 or 1 mg kg-1 and the plasma drug concentration measured spectrophotometrically at frequent intervals for up to 48 hours. Isometamidium chloride concentrations were found to be 9.8 +/- 0.2 and 8.7 +/- 0.2 micrograms ml-1 half an hour after treatment with 1 and 0.5 mg kg-1, respectively, and 1.7 +/- 0.3 and 0.7 +/- 0.3 micrograms ml-1 after 24 hours. No measurable drug concentration was found 48 hours after dosing.
D000818:Animals; D002162:Camelus; D005260:Female; D007275:Injections, Intravenous / Q000662:veterinary; D008297:Male; D010617:Phenanthridines / Q000008:administration & dosage / Q000097:blood*; D013397:Sudan; D013997:Time Factors; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000097:blood*; D014353:Trypanosomiasis, African / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*
D010617:Phenanthridines; D014344:Trypanocidal Agents; C000702:isometamidium chloride