Hypolipidemic activity of 4-pyrimidinecarboxylic acids in CF1 mice.
A series of 4-pyrimidinecarboxylic acids were evaluated for hypolipidemic activity in mice at 20-30 mg/kg/d ip. A number of these derivatives were observed to be active at this dose. Substitution of the hydroxyl group in position 2 and 6 of the 4-pyrimidinecarboxylic acid with a sulfhydryl and an amino group, respectively, led to a compound which produced a greater than 40% reduction of serum cholesterol and triglyceride levels in mice. Similarly, a compound which was substituted with an amino group in position 2 and an isobutyl group in position 5 led to equally potent activity as a hypolipidemic agent.
D000818:Animals; D002264:Carboxylic Acids / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002994:Clofibrate / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011743:Pyrimidines / Q000494:pharmacology*
D002264:Carboxylic Acids; D000960:Hypolipidemic Agents; D011743:Pyrimidines; D002994:Clofibrate