In vitro toxicity of MS sera correlates with new clinical signs.
In vitro toxicity of sera from 10 MS patients was followed for up to 3 years. Myelinotoxicity and cytotoxicity measured as radiolabel release from rat cerebellar explants were almost continuously higher in than in controls while peaks of radiolabel release were associated with the emergence of new clinical signs in the MS patients.
D000328:Adult; D001327:Autoimmune Diseases / Q000276:immunology; D005260:Female; D006801:Humans; D007106:Immune Sera; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000276:immunology*
D007106:Immune Sera