Antagonism by taurine of pressure-induced tremor in the guinea pig.
The tremorogenic effect of high pressure was antagonized in guinea pigs by intravenous treatment with taurine in doses of 250 and 500 mg/kg. Also pretreatment with 250 mg/kg taurine suppressed tremor development as evidenced by increased threshold and decreased amplitude. It is hypothesized that antagonism of pressure-induced tremor by taurine may be related to changes in membrane calcium transport.
D000818:Animals; D001274:Atmospheric Pressure; D004056:Differential Threshold; D004569:Electroencephalography; D006168:Guinea Pigs; D008297:Male; D009422:Nervous System Diseases / Q000150:complications; D013577:Syndrome; D013654:Taurine / Q000627:therapeutic use*; D013997:Time Factors; D014202:Tremor / Q000150:complications / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology
D013654:Taurine