Comparative evaluation of the vasodilator effect of verapamil, nifedipine and diltiazem on isolated perfused coronary arteries of rabbit.
In experiments with isolated perfused rabbit heart, nifedipine (1, 2 and 4 micrograms) produced a dose-dependent increase in coronary outflow (P less than 0.01). On the other hand effects after verapamil and diltiazem were negligible in such doses, though in high doses (10, 20 and 40 micrograms) they produced a significant (P less than 0.01) increase in coronary outflow. In experiments where noradrenaline (0.1 micrograms/ml) was added in the perfusion fluid, nifedipine (1, 2 and 4 micrograms), as well as verapamil and diltiazem (10, 20 and 40 micrograms) produced a dose-dependent, significant increase in coronary outflow (P less than 0.01).
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003331:Coronary Vessels / Q000187:drug effects*; D004110:Diltiazem / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009543:Nifedipine / Q000494:pharmacology; D011817:Rabbits; D014664:Vasodilation / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D014700:Verapamil; D004110:Diltiazem; D009543:Nifedipine