Experimental endometriosis and fertility: compared effects of an antigonadotropin (danazol) and an antiprostaglandin (indomethacin).
The possible role of prostaglandins in infertility associated with endometriosis is not fully understood. We therefore compared the efficacy of danazol, the drug chosen for treating this disease with that of indomethacin, an anti-prostaglandin, in rats affected with experimentally produced endometriosis. Endometriosis was induced in two groups of ten rats. The rats in group A were given danazol orally and those in group B were given peritoneal injections of indomethacin. The resulting fertility rates were very good in group B and less so in group A. Group A showed better anatomical findings, but group B gave improved results regarding adhesions.
D000284:Administration, Oral; D000818:Animals; D003613:Danazol / Q000008:administration & dosage / Q000627:therapeutic use*; D004715:Endometriosis / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D007213:Indomethacin / Q000008:administration & dosage / Q000627:therapeutic use*; D007274:Injections, Intraperitoneal; D011245:Pregnadienes / Q000627:therapeutic use*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D011245:Pregnadienes; D003613:Danazol; D007213:Indomethacin