[Effect of fetal adrenal hormones on the reactivity of the hypothalamo-hypophyseal-adrenocortical system in the adult rat].
It was found in the experiments on adult males, descendants of the intact or adrenalectomized (prior to mating) female rats which were injected during the pregnancy with adrenaline, hydrocortisone or saline solution, that the reaction of their hypophysial-adrenocortical system to emotional stress or injection of noradrenaline into brain were inversely proportional to the content of corticosteroids, rather than of adrenaline, in the blood of their mothers during the pregnancy. On the other hand, the coupled changes of the levels of corticosteroids and adrenaline in the blood of pregnant mothers only was accompanied by the marked decrease in the sensitivity of brain cholinergic mechanisms in descendants. Hence, the changes of the levels of both adrenaline and corticosterids in the blood of pregnant females modify the reactivity of hypophysial-adrenocortical system of adult descendants, apparently, via the development of brain neurochemical mechanisms in the foetuses. But the role of these hormones is different.
D015062:11-Hydroxycorticosteroids / Q000097:blood; D000302:Adrenal Cortex / Q000187:drug effects* / Q000196:embryology; D000315:Adrenalectomy; D000818:Animals; D001921:Brain / Q000187:drug effects; D002217:Carbachol / Q000494:pharmacology; D003404:Creatinine / Q000494:pharmacology; D004338:Drug Combinations / Q000494:pharmacology; D004837:Epinephrine / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects* / Q000196:embryology; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D013315:Stress, Psychological / Q000097:blood
D015062:11-Hydroxycorticosteroids; D004338:Drug Combinations; C014050:creatinine sulfate, serotonin drug combination; D012701:Serotonin; D002217:Carbachol; D003404:Creatinine; D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine
Vliianie gormonov nadpochechnikov ploda na reaktivnost' gipotalamo-gipofizarno-adrenokortikal'noĭ sistemy vzroslykh krys.