[Effect of modification of the lipid bilayer on the functioning of the electron transport chain of endoplasmic reticulum membranes in nitrosodiethylamine-induced hepatic carcinogenesis].
The kinetics of cytochrome P-450 content in endoplasmic reticulum membranes at different stages of hepatocarcinogenesis was studied under the influence of unsaturated fatty acids by the EPR method. At early stages of carcinogenesis the preparations containing oleic, linoleic and arachidonic acids prevent changes in the cytochrome P-450 content usually observed in case of nitrosodiethylamine introduction. The diet containing unsaturated fatty acids has a stabilizing effect revealed by the similar changes in the content of cytochrome P-450, phosphatidyl choline and fatty acids composition and also in the level of organization of the endoplasmic reticulum membrane lipid bilayer.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004052:Diethylnitrosamine; D004579:Electron Transport / Q000187:drug effects; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000201:enzymology*; D005227:Fatty Acids / Q000032:analysis; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D007700:Kinetics; D008051:Lipid Bilayers / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000201:enzymology*; D008297:Male; D008563:Membrane Lipids / Q000032:analysis; D051381:Rats; D013997:Time Factors
D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D008051:Lipid Bilayers; D008563:Membrane Lipids; D004052:Diethylnitrosamine; D003577:Cytochrome P-450 Enzyme System
Vliianie modifikatsii lipidnogo bisloia na funktsionirovanie élektrontransportnoĭ tsepi membran éndoplazmaticheskogo retikuluma pri gepatokantserogeneze, indutsirovannom nitrozodiétilaminom.