[Biophysical mechanisms and kinetics of thrombocyte aggregation].
The basic stages of platelet interaction and their relationship with kinetics of aggregation are considered. The aggregation is expressed theoretically as adsorbtion of stimulated platelets on the agglutinative surface, including surfaces of single cells and all aggregates that are formed. It is also suggested that the inductor determines the number of activated cells, and that cofactors of aggregation increase the reactivable surface aggregating platelets as a result of interaction with receptors of the platelet membrane. Equations are deduced for describing the dependence of aggregation kinetics from the concentration of inductor and cofactor of aggregation. A method is proposed for determination of binding parameters of inductor and aggregation cofactors with cell membranes by kinetic curves of aggregation.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D055592:Biophysical Phenomena; D001703:Biophysics; D001792:Blood Platelets / Q000502:physiology; D002118:Calcium / Q000494:pharmacology; D002450:Cell Communication; D004305:Dose-Response Relationship, Drug; D005340:Fibrinogen / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count; D013997:Time Factors
D000244:Adenosine Diphosphate; D005340:Fibrinogen; D002118:Calcium
Biofizicheskie mekhanizmy i kinetika agregatsii trombotsitov.