Vitamin A and biochemical development. I. Effect of postnatal excess vitamin-A administration on lipogenesis in various organs of the rat.
The effect of the administration of an excessive dose of vitamin A (1,000 IU) to rat pups on the 4th, 6th, 8th and 10th days of age was studied on the contents of saponifiable (total fatty acids) and non-saponifiable (cholesterol) lipids. Lipogenesis and cholesterogenesis was studied with the help of sodium-1-14C-acetate incorporation. The heart, liver and lung showed impaired lipogenesis while in the brain only cholesterogenesis was affected.
D000085:Acetates / Q000378:metabolism; D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002784:Cholesterol / Q000096:biosynthesis; D005227:Fatty Acids / Q000096:biosynthesis; D005260:Female; D006321:Heart / Q000187:drug effects; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014801:Vitamin A / Q000494:pharmacology*
D000085:Acetates; D005227:Fatty Acids; D008055:Lipids; D014801:Vitamin A; D002784:Cholesterol