Evaluation of the neurovirulence test of oral poliovaccines in Japan during the period 1963-1982.
The present study showed that the neurovirulence test for the lesion-inducing virus dose in the spinal cord in 50% of monkeys inoculated with oral polio-vaccine (Sabin) (LID50) reflected to a large extent safety and efficacy of the vaccine upon administration to children. The degree of attenuation of the vaccine in terms of LID50 appeared to be related to the decrease in the vaccine-associated cases as well as the seroconversion rate. An exceptional case, however, was noted in which lot No. 301 was not classified into less attenuated vaccine by the neurovirulence test. This fact suggests that the method we have employed awaits further improvement.
D000818:Animals; D002648:Child; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007564:Japan; D008252:Macaca fascicularis; D011051:Poliomyelitis / Q000209:etiology*; D011055:Poliovirus Vaccine, Oral / Q000009:adverse effects* / Q000302:isolation & purification / Q000633:toxicity
D011055:Poliovirus Vaccine, Oral