title: Pregnancy outcome after combined amputation and conization of the uterine cervix.
abstract: The outcome of 109 pregnancies after combined amputation and conization of the uterine cervix for CIN was compared with 204 previous pregnancies of the same 84 women. Late spontaneous abortion and preterm delivery occurred significantly more often after the operation than before it (p less than 0.001). The occurrence of early abortion was equal in both groups. The rate of legal pregnancy termination of the postconization pregnancies increased with the age of the women at the time of conization. The rate of caesarean sections (25.5%) in conized patients was significantly higher (p less than 0.05) than the mean section rate in the clinic (14.6%) during the study period. One fourth of them were done for chorion-amnionitis suggesting cervical incompetence in these cases. However, prophylactic second trimester cerclage did not improve the prognosis of postconization pregnancies. Combined amputation and conization seems to be a significant risk factor in subsequent pregnancies requiring careful supervising of the patients.
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000328:Adult; D002584:Cervix Uteri / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008423:Maternal Age; D007752:Obstetric Labor, Premature / Q000209:etiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000209:etiology*; D002583:Uterine Cervical Neoplasms / Q000601:surgery*