The optimization of the analysis of 63Ni in urine.
A method has been developed that separates 63Ni from urine. The subsequent estimation of activity is by liquid scintillation counting. The urine is wet-ashed by a new procedure which is much faster than conventional ashing methods. Interfering phosphates are removed before a precipitation of Ni as the dimethylglyoxime complex. The effects of the carrier weight, the pH of the phosphate removal step and the pH of the dimethylglyoxime precipitation have been investigated and optimized to give a mean recovery of 97 +/- 8% for 63Ni. The detection limit as defined by Currie (1968) is estimated to be 4.0 pCi (147 mBq) per sample.
D006801:Humans; D008722:Methods; D009532:Nickel / Q000652:urine*; D011868:Radioisotopes / Q000032:analysis*
D011868:Radioisotopes; D009532:Nickel