Fatal pneumococcal epiglottitis in lupus overlap syndrome.
A 35-year-old woman with a six-year history of polymyositis, having developed a vasculitic skin rash in the first trimester of her first pregnancy and biopsy-proven lupus glomerulonephritis during the third trimester is described. Investigations performed one month post-partum revealed high DNA binding, the presence of RNP antibodies, a serum CH50 of 0% and a serum C2 of 1%. Despite marked clinical and serological improvement and the reduction of her prednisolone dose to 5 mgs./day, she died at one-year post-partum of acute pneumococcal epiglottitis.
D000328:Adult; D004826:Epiglottitis / Q000150:complications*; D005260:Female; D006801:Humans; D007827:Laryngitis / Q000150:complications*; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy; D009220:Myositis / Q000150:complications* / Q000188:drug therapy; D011008:Pneumococcal Infections / Q000150:complications*; D011239:Prednisolone / Q000627:therapeutic use; D013577:Syndrome
D011239:Prednisolone