Effectiveness of psoralens in mycosis fungoides.
A 6-year follow-up of 12 patients with mycosis fungoides (MF) treated with psoralen photochemotherapy (PUVA) at the Cleveland Clinic revealed that 7 patients are clear of MF with 4 no longer receiving therapy and 3 on maintenance PUVA. Five patients died within 2 years of onset of therapy. Of 25 others with MF who were treated at Northwestern University, 20 are clear or partially clear after PUVA. Plaque-stage MF responds best to this type of treatment; Sézary syndrome, erythrodermic MF, and tumor-stage MF respond poorly to PUVA.
D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006801:Humans; D009182:Mycosis Fungoides / Q000188:drug therapy*; D009588:Nitrogen Mustard Compounds / Q000008:administration & dosage; D011701:PUVA Therapy; D010778:Photochemotherapy; D012176:Retinoids / Q000008:administration & dosage
D009588:Nitrogen Mustard Compounds; D012176:Retinoids