Nerve growth factor induces plasma extravasation in rat skin.
The intradermal application of both mouse and bovine nerve growth factor induced dose-dependently increased vascular permeability as indicated by Evans blue extravasation. Plasma extravasation by nerve growth factor was markedly reduced by capsaicin pretreatment or a combination of H1- and H2-histamine antagonists. The finding that biologically inactive nerve growth factor failed to elicit protein leakage indicates that plasma extravasation by nerve growth factor is a characteristic of the biologically active molecule.
D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D002417:Cattle; D005070:Evans Blue; D005119:Extravasation of Diagnostic and Therapeutic Materials; D008297:Male; D051379:Mice; D009414:Nerve Growth Factors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000098:blood supply*
D009414:Nerve Growth Factors; D005070:Evans Blue