[Immunologic analysis of the pathology developing in mice as a results of intrauterine infection with the influenza virus].
The progency of C57BL/6 mice consisting of three groups: with signs of slow influenza infection ("dwarf"), "nude-like" resembling nude mice, and "nude-like" with spontaneous fur growth, was examined. The slow influenza infection in "dwarf" mice was found to be characterized by marked immunosuppression manifested by a sharp reduction of the number of antibody- and rosette-forming cells and blasttransformation of spleen lymphocytes into T- and B-mitogens. The most marked immuno-suppression was found in the "dwarfs" born to the females infected with the virus enriched with standard virions. "Nude-like" animals also had marked immunosuppression (particularly with regard to the rosette-formation), however, the "dwarfs" appeared to have more marked affection of B-cells as compared with "nude-like" mice. Gradual restoration of fur in a portion of "nude-like" animals (spontaneous growth) was due to sharp stimulation of immune responsiveness in them as manifested by a two-fold (as compared with the controls) increase in the number of antibody- and rosette-forming cells and normalization of spleen cell response to T- and B-mitogens. Differences between nude and "nude-like" mice consisting in the latter in the affection of not only T- but also B-link of immunity are discussed.
D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000276:immunology; D003673:Defective Viruses / Q000472:pathogenicity; D004392:Dwarfism / Q000276:immunology; D005260:Female; D005315:Fetal Diseases / Q000276:immunology*; D007111:Immunity, Cellular; D009980:Influenza A virus / Q000472:pathogenicity; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D009976:Orthomyxoviridae Infections / Q000276:immunology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology*; D012397:Rosette Formation; D012897:Slow Virus Diseases / Q000276:immunology*
Immunologicheskiĭ analiz patologii, razvivaiushcheĭsia u mysheĭ v rezul'tate vnutriutrobongo zarazheniia virusom grippa.