[Colony-forming ability of bone marrow hematopoietic cells in mice with transplanted leukemia during administration of carminomycin].
Effects of carminomycin on the colony-forming ability of bone marrow haemopoietic stem cells (CFUs) were compared in normal mice with steady state and actively regenerating bone marrow, and in P-388 and La leukemia-bearing mice. CFUs assays were performed 24 h after treatment of donor mice with the increasing doses of the drug. Leukemia-bearing mice received carminomycin on the 5th day after transplantation. The dose-effect curves were exponential for CFUS normal mice with both the steady state and active proliferation state of bone marrow. The maximal effect was found 24 h after injection of 0.7 mg/kg of carminomycin (ED50 for CFUS) being more pronounced in regenerating bone marrow. The dose-effect curves for leukemias were also exponential. In the case of La leukemia the killing of CFUs by carminomycin was the highest as compared with P-388 leukemia.
D000818:Animals; D002360:Carubicin / Q000627:therapeutic use / Q000633:toxicity*; D003114:Colony-Forming Units Assay; D003630:Daunorubicin / Q000031:analogs & derivatives*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000473:pathology; D007941:Leukemia P388 / Q000188:drug therapy / Q000473:pathology; D007942:Leukemia, Experimental / Q000188:drug therapy / Q000473:pathology*; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D051381:Rats
D002360:Carubicin; D003630:Daunorubicin
Kolonieobrazuiushchaia sposobnost' gemopoéticheskikh kletok kostnogo mozga mysheĭ s perevivnym leĭkozom pri vvedenii karminomitsina.