Kinetics of penetration and clearance of mezlocillin in the bronchopulmonary tract.
Mezlocillin is an expanded spectrum semisynthetic penicillin for parenteral administration, with a good activity against a wide range of pathogenic bacteria including most anaerobes. The pharmacokinetic parameters of mezlocillin were determined in serum and sputum at the first and the seventh day of treatment with 1 g/im/12 h in patients suffering from bronchopulmonary infections. In a second group of volunteer patients who had to undergo surgery for lung cancer, mezlocillin levels in pulmonary tissue and the corresponding serum levels were determined at different times after drug administration. The data obtained made it possible to obtain information on the penetration and clearance of this drug in the bronchopulmonary tract in comparison with that of the serum. The pharmacokinetic behaviour of mezlocillin ensures an efficient antibacterial action in the respiratory tract.
D001980:Bronchi / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008168:Lung / Q000378:metabolism*; D008802:Mezlocillin / Q000097:blood / Q000378:metabolism*; D013997:Time Factors
D008802:Mezlocillin