title: Effects of cholinergic stimulation of the caudate nucleus on active avoidance.
abstract: Experiments dealing with the effects of applications of cholinergic drugs into the caudate nucleus on learned behaviors have yielded contradictory results; both improvements and deficits have been found. In the present experiment choline was injected into the CN of rats previously trained in a two-way active avoidance task. The results show that an improvement in performance can be seen when a small dose of choline is used and suggest that the reported deficits in learned performance were due to an overactivation of acetylcholine receptors.
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002421:Caudate Nucleus / Q000187:drug effects*; D002794:Choline / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D007267:Injections; D007274:Injections, Intraperitoneal; D008297:Male; D010277:Parasympathomimetics / Q000494:pharmacology*; D011699:Putamen; D051381:Rats; D012601:Scopolamine / Q000494:pharmacology; D013268:Stimulation, Chemical
chemical_list: D010277:Parasympathomimetics; D012601:Scopolamine; D002794:Choline