[Effect of metronidazole on the intensity of cell respiration].
The time-course of the metronidazole (MZ) radiosensitizing effect after the administration of the agent to mice 7 days following the inoculation of ascites tumor cells is better correlated with the time-course of the MZ content in the above cells than with the time-course of their potential respiration intensity evaluated by the polarographic method in a closed unit. Five minutes after MZ administration the depression of respiration intensity reached 50% and might contribute to the radiosensitizing effect. After MZ administration not only "metronidazole" but also "oxygen" waves were recorded in ascites tumors of mice using the polarographic method.
D000818:Animals; D008795:Metronidazole / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism* / Q000532:radiotherapy; D010101:Oxygen Consumption / Q000187:drug effects* / Q000528:radiation effects; D011048:Polarography; D011836:Radiation Tolerance; D013997:Time Factors
D008795:Metronidazole
Vliianie metronidazola na intensivnost' kletochnogo dykhaniia.