title: Oxygen-carrying substitutes other than fluorochemicals.
abstract: Beside the fluorochemicals, the research for oxygen carrying blood substitutes is pursued in two directions: hemoglobin derivatives and oxygen-binding chelates. Trials with hemoglobin had to overcome the following difficulties: renal toxicity, leakage outside the intravascular compartment, high affinity for oxygen and intravascular clotting effects. For several of these untoward effects, a satisfactory correction has been found. Other substances studied for possible oxygen-carrying fluids are various metal chelates. Several of these appear to be promising compounds, whereas no chelate is yet ready for in vivo investigation.
mesh_terms: D000818:Animals; D001778:Blood Coagulation Disorders / Q000209:etiology; D001802:Blood Substitutes; D002614:Chelating Agents / Q000627:therapeutic use*; D006454:Hemoglobins / Q000302:isolation & purification; D006801:Humans; D007668:Kidney / Q000187:drug effects; D010108:Oxyhemoglobins / Q000378:metabolism
chemical_list: D001802:Blood Substitutes; D002614:Chelating Agents; D006454:Hemoglobins; D010108:Oxyhemoglobins