title: Study of serum and urine hydroxyproline level of patients with prostatic cancer.
abstract: The serum and urine hydroxyproline levels of patients with prostatic cancer were regularly studied for 30 months. Bone metastases were found in 4 patients at the beginning of the study; metastases formed in 8 patients during the test period, and in 9 patients no metastases formed during the study. At the time of X-ray diagnosis of metastasis, significantly higher serum and urine hydroxyproline levels and enzymatic phosphatase were found, but in the tests performed 3 months earlier, in spite of the negative X-ray results, the hydroxyproline results differed significantly from the reference values. The above findings support the use of the hydroxyproline test for the diagnosis of metastases.
mesh_terms: D000368:Aged; D001859:Bone Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000556:secondary*; D006801:Humans; D006909:Hydroxyproline / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000378:metabolism*
chemical_list: D006909:Hydroxyproline