title: A corpus callosal deficit in sequential analysis by schizophrenics.
abstract: This preliminary study evaluated interhemispheric (i.e., corpus callosal) information processing by chronic schizophrenic and normal subjects. In right-handed normals the left hemisphere has been reported to be superior in temporal sequential analysis. Consequently temporal information presented to the right hemisphere requires time to cross to the left hemisphere for analysis. Measurement of hemispheric laterality and corpus callosal transfer time were evaluated by a two-pulse temporal discrimination task. Two dot stimuli were presented with decreasing temporal separation during bilateral and unilateral conditions. Subjects were required to judge perceived simultaneity and nonsimultaneity of dot onset. The results indicate that left hemisphere function in chronic schizophrenic and normal controls is superior to the right hemisphere in temporal analysis. Corpus callosal transfer time was significantly slower for chronic schizophrenics than for normal controls.
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003337:Corpus Callosum / Q000503:physiopathology*; D004193:Discrimination Learning / Q000502:physiology; D004292:Dominance, Cerebral / Q000502:physiology; D006801:Humans; D008297:Male; D010364:Pattern Recognition, Visual / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology*; D012565:Schizophrenic Psychology; D012691:Serial Learning / Q000502:physiology*