title: A genetic model of dental reduction through the probable mutation effect.
abstract: A simulation approach is used in order to elucidate the nature of the hypothesized "probable mutation effect" as it applies to dental reduction in man. Computer-generated simulations of the accumulation of mutations in a human gene pool show the results of the proposed model under the influence of various parameters, as well as illustrating the nature of such genetic change through time. This approach supports a polygenic model of the probable mutation effect as a viable hypothesis for an explanation of the dental reduction which has occurred in some human populations over the last 40,000 years.
mesh_terms: D006801:Humans; D008957:Models, Genetic; D009154:Mutation; D009811:Odontometry; D011336:Probability; D014070:Tooth / Q000033:anatomy & histology*