Metabolism of nitrosamines by cytochrome P-450 isozymes.
Results are presented to show that N-nitrosodimethylamine demethylase is P-450 mediated and N-nitrosodimethylamine is efficiently metabolized by specific P-450 isozymes inducible by a group of new inducers. The P-450-mediated N-nitrosodimethylamine demethylase also responds differently to inhibitors when activities are compared with those of classical monooxygenase systems.
D000818:Animals; D001711:Biotransformation; D019392:Cytochrome P-450 CYP2E1; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000378:metabolism*; D004128:Dimethylnitrosamine / Q000378:metabolism; D004790:Enzyme Induction; D066298:In Vitro Techniques; D007527:Isoenzymes / Q000096:biosynthesis / Q000378:metabolism*; D007700:Kinetics; D008862:Microsomes, Liver / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D009602:Nitrosamines / Q000378:metabolism*; D010089:Oxidoreductases, N-Demethylating / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats; D013379:Substrate Specificity
D007527:Isoenzymes; D009602:Nitrosamines; D003577:Cytochrome P-450 Enzyme System; D019392:Cytochrome P-450 CYP2E1; D010089:Oxidoreductases, N-Demethylating; D004128:Dimethylnitrosamine