[Cellular and humoral immunity in asymptomatic carriers of the hepatitis B virus].
Eighty-eight asymptomatic HBsAg carriers were examined for cellular and humoral immunity and markers of virus B hepatitis in liver tissue and blood serum. The following results were obtained: HBsAg and HBcAg in liver tissue were found in 10 and 19 out of the 24 examinees, respectively, HBeAg and anti-Hbe in blood serum in 2 and 20 out of the 25 examinees, respectively. No alterations were recorded on the part of humoral immunity. Changes in cellular immunity manifested themselves by reduction in the number of T lymphocytes, and decreased response to PHA. Sensitization to HBsAg led to the purification of hepatitis B virus whereas the presence of simultaneous sensitization to liver-specific lipoprotein contributed to development of graver patterns of liver injury. The role of the immune system and hepatitis B virus itself in the pathogenesis of liver injury in asymptomatic HBsAg carriers is discussed.
D000293:Adolescent; D000328:Adult; D000917:Antibody Formation; D001323:Autoantibodies / Q000032:analysis; D002353:Carrier State / Q000276:immunology*; D005260:Female; D006509:Hepatitis B / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000032:analysis; D006512:Hepatitis B Core Antigens / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006513:Hepatitis B e Antigens / Q000032:analysis; D006801:Humans; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged
D001323:Autoantibodies; D006510:Hepatitis B Antibodies; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens; D006513:Hepatitis B e Antigens; D007136:Immunoglobulins
Sostoianie kletochnogo i gumoral'nogo immuniteta u bessimptomnykh nositeleĭ virusa gepatita B.