title: Protein and platelet interactions with polymer surfaces.
abstract: An attempt is made to develop an understanding of the basic mechanism governing the interaction of the major blood proteins and cells with polymer surfaces with a focus on thermodynamic approach. It is believed that such investigations may be helpful to provide a rational for the design of suitable cardiovascular prosthetic materials and to choose materials in such a way that adsorption of certain proteins eg. 'fibrinogen' is thermodynamically unfavourable compared to adsorption of other proteins eg. 'albumin'.
mesh_terms: D000327:Adsorption; D001672:Biocompatible Materials; D001792:Blood Platelets / Q000502:physiology*; D001798:Blood Proteins / Q000502:physiology*; D004560:Electricity; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D010973:Platelet Adhesiveness; D011108:Polymers; D019736:Prostheses and Implants; D011474:Prosthesis Design; D012212:Rheology; D013499:Surface Properties; D013816:Thermodynamics
chemical_list: D001672:Biocompatible Materials; D001798:Blood Proteins; D011108:Polymers