Effect of migraine attacks on paracetamol absorption.
The absorption of effervescent paracetamol (1000 mg) was investigated in nine female patients during a migraine attack and in the same patients when headache free. Migraine attack decreased (P less than 0.05) the areas under the serum paracetamol concentration-time curves (AUC) of 0-2 h, 0-4 h and 0-6 h and the peak serum concentration. The severity of nausea correlated significantly with the decrease in the AUC values. Our results support findings of delayed gastric emptying in migraine attacks. Both a delay and an impairment of drug absorption may follow.
D000082:Acetaminophen / Q000097:blood / Q000378:metabolism*; D000328:Adult; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D008875:Middle Aged; D008881:Migraine Disorders / Q000378:metabolism*; D009325:Nausea / Q000378:metabolism
D000082:Acetaminophen