[Prevention of the chronic persistence of typhoid microbes in rabbits with thymostimulin].
Typhoid infection was reproduced by introducing the infective agent into the bone marrow of noninbred rabbits. After the injection of thymostimulin on the first day of infection the release of typhoid bacilli continued for 1-3 weeks; when thymostimulin was injected on day 20, the release of typhoid bacilli stopped in two weeks. In the control group the release of typhoid bacilli continued during the whole term of observation. The injection of thymostimulin at an early period after infection was thus found to prevent the development of chronic typhoid infection with the elimination of the infective agent from the body of rabbits.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D002908:Chronic Disease; D004353:Drug Evaluation, Preclinical; D007111:Immunity, Cellular / Q000187:drug effects; D011817:Rabbits; D013949:Thymus Extracts / Q000627:therapeutic use*; D013997:Time Factors; D014435:Typhoid Fever / Q000276:immunology / Q000517:prevention & control*
D000276:Adjuvants, Immunologic; D013949:Thymus Extracts; C031407:thymostimulin
Preduprezhdenie khronicheskoĭ persistentsii briushnotifoznykh mikrobov u krolikov timostimulinom.