[The effect of cisplatin on the healing of intestinal anastomosis in the rat. Microangiography and light microscopy studies].
The influence of a single dose cisplatin on wound healing of enterostomies in rats was investigated by measurement of the wound-breaking strength, microangiographically and histologically. Cisplatin (5 mg/kg body weight) was given on day-1 or day-5 preoperatively. Cisplatin led to a significant reduction of the wound-breaking strength, mostly marked on day +14 after operation. The reasons are: a reduced induction of connective tissue proliferation; an inhibition of proliferation of fibroblasts and endothelial cells, and a retardation of vessel proliferation.
D000818:Animals; D002945:Cisplatin / Q000494:pharmacology*; D007420:Intestine, Large / Q000601:surgery; D007421:Intestine, Small / Q000601:surgery; D007422:Intestines / Q000098:blood supply / Q000473:pathology / Q000601:surgery*; D008297:Male; D008852:Microradiography; D011292:Premedication; D051381:Rats; D011919:Rats, Inbred Strains; D014945:Wound Healing / Q000187:drug effects*
D002945:Cisplatin
Einfluss von Cisplatin auf die Heilung von Darmanastomosen der Ratte. Mikroangiographische und lichtmikroskopische Untersuchungen.