title: Mitral valve replacement in the neonate: a report of two cases.
abstract: Mitral valve replacement was performed in two critically ill neonates with severe mitral stenosis and regurgitation. Both patients had coexisting severe aortic stenosis previously treated by transventricular aortic valve dilatation. Preoperative echocardiography showed a mitral annulus measuring between 11 and 12 mm in diameter--too small for any of the commercially available free-standing valve prostheses. Accordingly, the porcine valve from a commercially available 12-mm external-valved conduit was removed and sutured into position. The function of the valve was satisfactory in both cases and cardiopulmonary bypass was discontinued easily with a good cardiac output established in both. Both patients died--one at 20 h and one 36 h after surgery. In each case, the immediate cause of death was acute bleeding secondary to preexisting hepatic failure and depletion of coagulation factors. At autopsy, both prostheses had been correctly placed and were competent. Left ventricular outflow tract obstruction secondary to strut imposition was not evident. Both patients were very ill preoperatively. Although neither patient survived mitral valve replacement, we were encouraged by the relative hemodynamic improvement in the immediate postoperative period. We believe that prosthetic valve replacement could become a viable therapy for the neonate with severe mitral valve abnormalities.
mesh_terms: D001021:Aortic Valve / Q000473:pathology; D001024:Aortic Valve Stenosis / Q000151:congenital / Q000473:pathology / Q000601:surgery; D001705:Bioprosthesis; D004106:Dilatation; D004374:Ductus Arteriosus, Patent / Q000601:surgery; D005260:Female; D006350:Heart Valve Prosthesis; D006439:Hemodynamics; D006801:Humans; D007223:Infant; D008943:Mitral Valve / Q000473:pathology; D008944:Mitral Valve Insufficiency / Q000151:congenital* / Q000473:pathology / Q000601:surgery; D008946:Mitral Valve Stenosis / Q000151:congenital* / Q000473:pathology / Q000601:surgery