[Pharmacological correction of disordered function of the myocardial contractile proteins].
The ability of some drugs to normalize the disturbed interaction of myocardial contractile proteins with ATP determined by superprecipitation of myocyte actomyosin was studied in experimental allergic and caffeine-adrenaline-induced injury to the rabbit myocardium. Ethimizole (2.5 mg/kg) appeared the most effective, while isolanide (0.005 mg/kg), contrykal (500 Units/kg), propranolol (1 mg/kg) and amidopyrine (10 mg/kg) were less effective. The action of prednisolone (5 mg/kg) appeared especially demonstrable in allergic myocardial injury.
D000205:Actomyosin / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002110:Caffeine / Q000633:toxicity; D002316:Cardiotonic Agents / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004837:Epinephrine / Q000633:toxicity; D007114:Immunization; D009124:Muscle Proteins / Q000378:metabolism*; D009205:Myocarditis / Q000188:drug therapy* / Q000209:etiology / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D011817:Rabbits; D013997:Time Factors
D002316:Cardiotonic Agents; D009124:Muscle Proteins; D002110:Caffeine; D000255:Adenosine Triphosphate; D000205:Actomyosin; D004837:Epinephrine
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