Biochemical aspects of cesium administration in tumor-bearing mice.
The effect of pretreatment with CsCl on mice bearing sarcoma I implants was studied as a function of duration of treatment period, life span and tissue Cs+ and K+ levels. Treatment with CsCl for 14 consecutive days prior to sarcoma implantation resulted in initial reduction of the tumor-mediated mortality compared to controls and to a one week pretreatment period with identical doses of CsCl. A large accumulation of endogenous K+ was noted in tumor mass compared to nonmalignant tissue of the same animals or to tumor-free controls receiving identical Cs-treatment. The entry of exogenously administered Cs+ into malignant tissue was less than that accumulating in respective controls. The accumulation of Cs+ in tumor mass was dose-dependent. The ratio of K+:C+ was greater in tumor tissue than in nonmalignant tissue. The results suggest that a critical balance between these alkali metals may be required for adequate Cs effect against the tumor studied.
D000818:Animals; D002586:Cesium / Q000378:metabolism / Q000627:therapeutic use*; D002712:Chlorides; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D011188:Potassium / Q000378:metabolism; D012513:Sarcoma, Experimental / Q000188:drug therapy* / Q000378:metabolism
D002712:Chlorides; D002586:Cesium; C028019:cesium chloride; D011188:Potassium