Unilateral glomerular DNA-anti-DNA complex formation in situ.
DNA has a high affinity for collagenous structures such as glomerular basement membrane. DNA was infused into the isolated left kidney in rats to determine whether this antigen though negatively charged would bind to glomerular structures. Mainly mesangial localization with minimal capillary localization was noted. Infusion of anti-DNA antibody after glomerular DNA binding allowed for formation of DNA-anti-DNA deposits in situ.
D000818:Animals; D000936:Antigen-Antibody Complex; D000937:Antigen-Antibody Reactions; D001327:Autoimmune Diseases / Q000276:immunology; D001485:Basement Membrane / Q000276:immunology; D003176:Complement C3; D004247:DNA / Q000276:immunology*; D005921:Glomerulonephritis / Q000276:immunology; D007074:Immunoglobulin G; D007678:Kidney Glomerulus / Q000276:immunology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000936:Antigen-Antibody Complex; D003176:Complement C3; D007074:Immunoglobulin G; D004247:DNA