title: Heterochromatinization as a key factor in aging.
abstract: An analysis of observations on modifications during aging of the characteristics of chromosomes during the mitotic cycle of their mutations and unscheduled aging leads to the conclusion that enhanced heterochromatinization during aging prevents the action of reparative enzymes, and results in increased numbers of cells with chromosomal aberrations.
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging; D002869:Chromosome Aberrations; D004260:DNA Repair; D006570:Heterochromatin / Q000648:ultrastructure*; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008875:Middle Aged; D008938:Mitosis; D009154:Mutation; D009697:Nucleolus Organizer Region / Q000648:ultrastructure
chemical_list: D006570:Heterochromatin