title: Ascorbic acid nutritional status does not affect the biochemical response to paraquat.
abstract: Guinea pigs were subjected to dietary control of ascorbic acid intake to produce deficient, normal, and supplemented tissue ascorbate concentrations. Paraquat, a potent pulmonary toxin, was then administered. Tissue distribution and covalent binding of paraquat were not affected significantly by ascorbate nutritional status except for decreased 24-hr kidney burdens in deficient animals. Paraquat increased pulmonary thiobarbituric acid reactivity and mixed disulfide formation, but no evidence of either a protective or a potentiative interaction of endogenous ascorbate and paraquat was observed. This study indicates that alteration of endogenous ascorbic acid levels does not alter the biochemical response to paraquat.
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001205:Ascorbic Acid / Q000032:analysis / Q000502:physiology*; D004220:Disulfides / Q000032:analysis; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008168:Lung / Q000032:analysis; D008297:Male; D010269:Paraquat / Q000378:metabolism / Q000633:toxicity*; D013858:Thiobarbiturates / Q000494:pharmacology; D014018:Tissue Distribution
chemical_list: D004220:Disulfides; D013858:Thiobarbiturates; D010269:Paraquat; D001205:Ascorbic Acid