Pharmacokinetic study of 3H-labelled PAF-acether II. Comparison with 3H-labelled lyso-PAF-acether after intravenous administration in the rabbit and protein binding.
The blood and plasma kinetics of intravenously administered 3H-labelled PAF-acether were determined in seven rabbits. PAF-acether was rapidly distributed and slowly eliminated. Individual variations were very small. The main route of metabolism involves deacetylation of the PAF-acether into lyso-PAF-acether, leading to an equilibrium between the two molecules (10%/90%). This equilibrium, observed within 30 minutes, was still the same after 6 hours suggesting in vivo reacetylation of lyso-PAF-acether into PAF-acether. However, this could not be verified. After intravenous administration of lyso-PAF-acether in two rabbits, PAF-acether could not be found in any blood sample. The pharmacokinetic behaviour of both PAF-acether and lyso-PAF-acether can be described by a three-compartment model.
D000818:Animals; D007700:Kinetics; D010972:Platelet Activating Factor / Q000031:analogs & derivatives / Q000378:metabolism / Q000502:physiology*; D011485:Protein Binding; D011817:Rabbits; D014316:Tritium
C029271:O-deacetyl platelet activating factor; D010972:Platelet Activating Factor; D014316:Tritium