title: Saturable uptake of [3H]-tryptamine in rabbit platelets is inhibited by 5-hydroxytryptamine uptake blockers.
abstract: [3H]-tryptamine is taken up by rabbit platelets through an active and saturable process which is temperature sensitive, sodium-dependent and inhibited by imipramine and non-tricyclic 5-hydroxytryptamine (5-HT) uptake blockers. There is an excellent correlation between the Ki for the inhibition of [3H]-tryptamine and [3H]-5-HT uptake in rabbit platelets for a series of 5-HT uptake blockers. These results indicate that [3H]-tryptamine is actively transported through the membrane of blood platelets by the same carrier that transports 5-HT.
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D007099:Imipramine / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D011817:Rabbits; D012702:Serotonin Antagonists / Q000494:pharmacology*; D012964:Sodium / Q000502:physiology; D014363:Tryptamines / Q000097:blood*
chemical_list: D012702:Serotonin Antagonists; D014363:Tryptamines; C030820:tryptamine; D012964:Sodium; D007099:Imipramine