Synthesis of some 6 beta-acetylthio hydroxysteroids.
The reactions of 3 beta-hydroxy-20-oxo-5-pregnene-16 alpha-carbonitrile, 3 beta-hydroxy-5-androsten-17-one, 3 beta-hydroxy-5-pregnen-20-one, and 5-cholesten-3 beta-ol with thioacetic acid in dioxane afford mainly 6 beta-acetylthio derivatives which were characterized by IR, NMR (1H, 13C), and mass spectroscopy. A similar reaction of 17 beta-hydroxy-1,4-androstadien-3-one yields chiefly the known 1 alpha-SCOCH3 derivative.
D002614:Chelating Agents / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D006914:Hydroxysteroids / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008628:Mercury / Q000037:antagonists & inhibitors; D008968:Molecular Conformation; D013055:Spectrophotometry, Infrared
D002614:Chelating Agents; D006914:Hydroxysteroids; D008628:Mercury