Antagonism of acute alcohol intoxication by naloxone.
We have previously shown that proprietary naloxone hydrochloride (Narcan) reverses the disturbance of the redox states of the hepatic NAD(P) couples and causes a simultaneous lowering of blood-ethanol concentration in acutely-ethanol-intoxicated rats. We now confirm these findings by using pure naloxone hydrochloride and demonstrate the inability of the methyl-4-hydroxybenzoate preservative present in the Narcan ampoules to influence the above effects of ethanol.
D000435:Alcoholic Intoxication / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D000431:Ethanol / Q000097:blood; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D009270:Naloxone / Q000627:therapeutic use*; D010084:Oxidation-Reduction; D010226:Parabens / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
D010226:Parabens; D009243:NAD; D009270:Naloxone; D000431:Ethanol; D009249:NADP; C015358:methylparaben