Neuropeptide Y in human spinal cord.
The distribution of a newly described peptide, neuropeptide Y (NPY) within the human spinal cord has been determined using radioimmunoassay and immunocytochemistry. Higher concentrations were found in the lumbar (49.9 +/- 6.8 pmol/g) and sacral (47.0 +/- 10.6 pmol/g) regions than in the cervical (27.6 +/- 2.7 pmol/g) and thoracic spinal cord (33.8 +/- 5.3 pmol/g). Immunocytochemistry revealed numerous nerve fibers containing NPY in the spinal cord; these were particularly concentrated in the substantia gelatinosa of the dorsal horn. In the ventral spinal cord NPY-containing nerves were sparse becoming more abundant in lumbosacral segments.
D000328:Adult; D000368:Aged; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007106:Immune Sera; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009478:Neuropeptide Y; D011863:Radioimmunoassay; D013116:Spinal Cord / Q000032:analysis* / Q000166:cytology; D014018:Tissue Distribution
D007106:Immune Sera; D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y