[Bradykinin, thrombin and prostaglandins as modulators of microthrombogenesis in local injury of the blood vessel wall].
The microthrombogenesis parameters were studied after local laser injury to the rat mesenterial venule in the presence of infusion of bradykinin (20 micrograms/kg/min) and thrombin (10 Units/kg/min). Bradykinin diminished and thrombin, on the contrary, increased the hemostasis parameters, this effect being observed only during the first minutes after the drug infusion. Activation of the blood kallikrein-kinin system preceded the action of thrombin. It is suggested that apart from prostaglandins, the component of the Hageman factor system may play an important role in the control of microhemostasis in the injured vascular wall.
D000818:Animals; D001777:Blood Coagulation; D001920:Bradykinin / Q000502:physiology*; D007610:Kallikreins / Q000097:blood; D007705:Kinins / Q000097:blood; D008297:Male; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013917:Thrombin / Q000502:physiology*; D014680:Veins / Q000503:physiopathology*; D014699:Venules / Q000293:injuries / Q000503:physiopathology*
D007705:Kinins; D011453:Prostaglandins; D007610:Kallikreins; D013917:Thrombin; D001920:Bradykinin
Bradikinin, trombin i prostaglandiny kak moduliatory protsessa mikrotromboobrazovaniia pri lokal'nom povrezhdenii sosudistoĭ stenki.