[Effect of T-activin on peripheral immunity organs in intact and thymectomized mice].
Morphometry of the spleen, axillary lymph nodes and cytological assay of the bone marrow and peripheral blood were performed in (CBA X C57BL)F1 mice 1, 5, 10 and 15 days after subcutaneous injection of 0.5 microgram T-activin to intact and thymectomized (when adult) mice 2 months after operation. It was demonstrated that in intact animals, injection of T-activin stimulated the whole system of immunogenesis. The time course of plasmatization and the response of the germinative centers differing from that seen during antigen administration suggests that T-activin is not immunogenous, acting as a stimulant of the previous immune responses. The permanent amount of the degenerating cells attests to the lack of the toxic drug effect.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000276:immunology*; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000187:drug effects / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051379:Mice; D010455:Peptides; D013154:Spleen / Q000187:drug effects / Q000276:immunology*; D013934:Thymectomy; D013949:Thymus Extracts / Q000494:pharmacology*; D013950:Thymus Gland / Q000502:physiology*
D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin
Vliianie T-aktivina na perifericheskie organy immuniteta intaktnykh i timéktomirovannykh mysheĭ.