title: Synenkephalin is coreleased with Met-enkephalin from neuronal terminals in vitro.
abstract: Synenkephalin, the amino-terminal 1-70 residues of proenkephalin, is released intact from bovine globus pallidus and neurohypophysis following potassium-induced depolarization in vitro via a Ca2+-dependent mechanism. The release of synenkephalin accompanies that of Met-enkephalin in a molar ratio of 1/4. In contrast to Met-enkephalin, which is readily destroyed when released, synenkephalin is not destroyed.
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology; D002417:Cattle; D004744:Enkephalin, Methionine / Q000378:metabolism*; D004745:Enkephalins / Q000378:metabolism*; D005917:Globus Pallidus / Q000378:metabolism*; D066298:In Vitro Techniques; D009411:Nerve Endings / Q000378:metabolism; D010904:Pituitary Gland, Posterior / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D011498:Protein Precursors / Q000378:metabolism*
chemical_list: D004745:Enkephalins; D011498:Protein Precursors; D004744:Enkephalin, Methionine; C036693:synenkephalin; D011188:Potassium; D002118:Calcium