Evaluation of anti-emetics in association with intrathecal diamorphine.
Intrathecal diamorphine is associated with a high incidence of emetic symptoms. Six anti-emetic drugs representing various chemical groups were given in random order to patients undergoing total hip replacement and who had received intrathecal diamorphine 0.5-1.0 mg. The phenothiazines, perphenazine and prochlorperazine, were more effective than the others. It is suggested that this might be a useful model for the evaluation of new anti-emetics.
D000368:Aged; D000932:Antiemetics / Q000627:therapeutic use*; D004341:Drug Evaluation; D003932:Heroin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006622:Hip Prosthesis; D006801:Humans; D007278:Injections, Spinal; D009325:Nausea / Q000517:prevention & control*; D010149:Postoperative Pain / Q000188:drug therapy; D011897:Random Allocation; D014839:Vomiting / Q000517:prevention & control*
D000932:Antiemetics; D003932:Heroin