New low-molecular inhibitors of pancreatic elastase with possible in vivo application: alkylamides of N-acylated tripeptides.
Out of a series of alkylamides of N-acylated tripeptides, Glt-(Ala)2-Pro-NH-Et and Glt-(Ala)3-NH-Pr were found to be potent inhibitors of porcine and human pancreatic elastase, and because they are free of toxic groups they might be considered for in vivo application.
D000818:Animals; D006801:Humans; D007700:Kinetics; D009842:Oligopeptides / Q000494:pharmacology*; D010179:Pancreas / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors*; D013552:Swine
D009842:Oligopeptides; C037894:glutaryl-alanyl-alanyl-prolylethylamide; C037893:glutaryl-alanyl-alanyl-alanyl-propylamide; D010196:Pancreatic Elastase