Haemopoiesis by clonal succession?
Alloenzymes of phosphoglycerate kinase (Pgk-1A and 1B), an X-linked enzyme of the glycolytic pathway that is expressed on all somatic cells, were used to study properties of developmentally early haemopoietic cells of mice (high proliferation potential colony-forming cells, HPP CFC) This study showed that: The colonies formed by HPP CFC are clones; There are distinct populations of HPP CFC that can respond to different haemopoietic growth factors; There are substantial differences in the proportions of Pgk alloenzymes of similar sets of HPP CFC found in similar and neighbouring bones; and In the whole animal, there is no evidence of any single population of HPP CFC that is permanently derived from a limited set of precursors.
D000818:Animals; D001853:Bone Marrow / Q000201:enzymology; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D002999:Clone Cells; D005260:Female; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000166:cytology* / Q000201:enzymology; D007527:Isoenzymes / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D010735:Phosphoglycerate Kinase / Q000378:metabolism
D007527:Isoenzymes; D010735:Phosphoglycerate Kinase