[The percutaneous effect of a heparin-allantoin-dexpanthenol combination in a specific ointment base. Anti-allergic, anti-inflammatory effect in the PCA test in the rat].
Local application of a heparin-allantoin-dexpanthenol (Hepathrombin-Adenylchemie) ointment to rats 15 min prior to induction of a passive cutaneous anaphylaxis (PCA) reaction inhibits the anaphylactic reaction as compared to the ointment base. Also, the Evans Blue content as a measure for vascular permeability and the oedema weights are reduced under the heparin containing ointment. The antiallergic/antiinflammatory effect is probably due to heparin.
D000287:Administration, Topical; D000481:Allantoin / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D004338:Drug Combinations / Q000494:pharmacology; D006493:Heparin / Q000494:pharmacology*; D008297:Male; D009823:Ointment Bases; D009824:Ointments; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D004338:Drug Combinations; D009823:Ointment Bases; D009824:Ointments; D010205:Pantothenic Acid; D000481:Allantoin; C013325:Ulcrux; D006493:Heparin
Untersuchungen zur perkutanen Wirksamkeit einer Heparin-Allantoin-Dexpanthenol-Kombination in spezieller Salbengrundlage. Antiallergische/antiinflammatorische Wirkung im PCA-Test bei der Ratte.