Efficacy of ivermectin in oral paste formulation against immature gastrointestinal and pulmonary nematodes in cattle.
The anthelmintic efficacy of ivermectin in oral paste formulation was evaluated against the 4th-stage larvae of 8 gastrointestinal nematodes and the common lung-worm in 14 experimentally inoculated calves. Two groups consisting of 7 calves each were formed by restricted randomization on body weight. The infective larvae were given orally to the animals on a staggered schedule so that the parasites were in the 4th larval stage when the animals were treated. One group was given vehicle paste, and the other group was treated with ivermectin in oral paste at the dose level of 200 micrograms/kg of body weight. The animals were killed 18 or 19 days after treatment. Ivermectin was 100% effective against Dictyocaulus viviparus, Oesophagostomum radiatum, Haemonchus placei, Ostertagia ostertagi, and Trichostrongylus axei and greater than 99% effective against Cooperia oncophora, C punctata, T colubriformis, and Nematodirus helvetianus.
D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000627:therapeutic use; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D004341:Drug Evaluation; D005767:Gastrointestinal Diseases / Q000188:drug therapy / Q000662:veterinary*; D007559:Ivermectin; D007783:Lactones / Q000008:administration & dosage* / Q000627:therapeutic use; D007814:Larva / Q000187:drug effects; D008174:Lung Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D009348:Nematoda / Q000187:drug effects; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D009824:Ointments
D000871:Anthelmintics; D007783:Lactones; D009824:Ointments; D007559:Ivermectin