Prolonged culture of cells from normal human thyroid tissue and toxic goiters.
Normal human thyroid cells and cells from patients with Grave's disease were cultured for 5 months (11 passages) in vitro. Both normal and diseased thyreocytes, similar in morphology, proliferated actively and responded to thyrotropin stimulation by cytoplasmic arborization of a part of the population. Slight inhibition of mitotic activity was present under the influence of thyrotropin.
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D006111:Graves Disease / Q000473:pathology*; D006801:Humans; D013961:Thyroid Gland / Q000166:cytology* / Q000473:pathology; D013972:Thyrotropin / Q000494:pharmacology
D013972:Thyrotropin