Bombesin and the C-terminal tetradecapeptide of gastrin-releasing peptide are growth factors for normal human bronchial epithelial cells.
Bombesin and the C-terminal portion of gastrin-releasing peptide (GRP14-27) each increase clonal growth rate and colony-forming efficiency of normal human bronchial epithelial cells. These effects occur in the presence or absence of an optimal concentration (5 ng/ml) of epidermal growth factor (EGF). In contrast to EGF bombesin and GRP14-27 do not stimulate cell migration. Thus, bombesin and the C-terminal fragment of gastrin-releasing peptide represent a new class of peptides mitogenic for normal human epithelial cells.
D000328:Adult; D001839:Bombesin / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects / Q000502:physiology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D002999:Clone Cells; D004848:Epithelium / Q000187:drug effects / Q000502:physiology; D019886:Gastrin-Releasing Peptide; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D010446:Peptide Fragments / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*
D006133:Growth Substances; D010446:Peptide Fragments; D010455:Peptides; D019886:Gastrin-Releasing Peptide; C041922:gastrin releasing peptide (14-27); D001839:Bombesin