title: Treatment of urinary incontinence after radical hysterectomy.
abstract: The results of therapy of eight previously untreated women without urinary fistulas who had been severely incontinent for three to eight years after radical hysterectomy are presented and the principles of management discussed. Radiologic and urodynamic studies are required to assess the bladder pressure response to filling, proximal urethral pressures, bladder neck closure at rest, and mobility of the bladder neck, to determine the mechanism responsible for the urine loss and to select appropriate therapy. Augmentation of proximal urethral pressures by medical or surgical means is required if the bladder neck is open at rest. All such patients improved dramatically on ephedrine, but tachyphylaxis developed in cases of total sphincter failure. Retropubic urethropexy did not relieve the incontinence in these cases, whereas a sling operation restored complete continence. If an incremental bladder pressure response to filling is present, operations to increase bladder outlet resistance are contraindicated. Treatment with anticholinergic medications was unsuccessful in these cases.
mesh_terms: D000230:Adenocarcinoma / Q000601:surgery; D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000601:surgery; D004809:Ephedrine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011312:Pressure; D014521:Urethra / Q000503:physiopathology / Q000601:surgery; D001743:Urinary Bladder / Q000503:physiopathology / Q000601:surgery; D014549:Urinary Incontinence / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology / Q000601:surgery*; D014563:Urodynamics; D002583:Uterine Cervical Neoplasms / Q000601:surgery; D014625:Vaginal Neoplasms / Q000601:surgery
chemical_list: D004809:Ephedrine