title: Toxic effects of selenium on growing swine fed corn-soybean meal diets.
abstract: A total of 96 crossbred pigs received various levels of sodium selenite to determine the effect of dietary selenium (Se) on growing swine fed corn-soybean meal diets. Levels of supplemental Se were 0, 4, 8, 12, 16 and 20 micrograms/g. There were linear decreases (P less than .01) in both gain and feed intake with increasing levels of dietary Se. Feed/gain increased numerically as dietary Se increased. Hair Se increased quadratically (P less than .01) and blood Se increased linearly (P less than .01) with increasing level of dietary Se. Cell volume and hemoglobin were not affected by dietary treatment. Increasing dietary Se significantly increased glutathione peroxidase (GSH-Px), glutamic-oxalacetic transaminase (GOT). and glutamic-pyruvic transaminase (GPT). External signs of selenosis were noted in some pigs fed 12 or 20 micrograms/g of Se. The toxic level of Se in a corn-soybean meal diet for crossbred pigs appears to be between 4 and 8 micrograms/g. Of variables studied, growth rate was the most sensitive indicator of chronic selenosis in swine.
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000821:Animal Feed / Q000633:toxicity*; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D005260:Female; D005527:Food, Fortified; D005979:Glutathione Peroxidase / Q000097:blood; D006197:Hair / Q000032:analysis; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D008297:Male; D020887:Selenious Acid; D012643:Selenium / Q000008:administration & dosage / Q000097:blood / Q000506:poisoning / Q000633:toxicity*; D013025:Glycine max; D013552:Swine / Q000254:growth & development*; D013553:Swine Diseases / Q000175:diagnosis; D003313:Zea mays
chemical_list: D006454:Hemoglobins; D005979:Glutathione Peroxidase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D020887:Selenious Acid; D012643:Selenium