The use of doubly-labeled 13C-acetate in the study of streptolydigin biosynthesis.
Using [13C2]acetate the biosynthesis of streptolydigin has been investigated. It has been demonstrated that a total of 4 acetate units are incorporated into the antibiotic, 3 into the acyl side chain and 1 into the tetramic acid portion.
D000085:Acetates / Q000378:metabolism*; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D002247:Carbon Isotopes; D002250:Carbon Radioisotopes; D009682:Magnetic Resonance Spectroscopy; D013302:Streptomyces / Q000378:metabolism*
D000085:Acetates; D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D002247:Carbon Isotopes; D002250:Carbon Radioisotopes; C100307:streptolydigin