Intrathecal morphine for pelvic and sacral pain caused by cancer.
Ten patients underwent placement of a lumbar subarachnoid catheter attached to a subcutaneous reservoir allowing daily injection of intrathecal morphine sulfate by family members. Sacral and pelvic pain were fairly well controlled. Neck and leg pain and pain mediated by the celiac plexus were not as well controlled by the intrathecal injection of morphine. The only significant complication was collection of cerebrospinal fluid around three reservoirs. Using this technique, narcotic concentration and frequency of administration can be easily altered to provide a safe but effective dose. Lumbar administration appears to block pain from lumbar and sacral dermatomes without the sedating and mood-altering effects of systemic narcotics.
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000150:complications / Q000188:drug therapy*; D005260:Female; D005770:Gastrointestinal Neoplasms / Q000150:complications / Q000188:drug therapy*; D005833:Genital Neoplasms, Female / Q000150:complications / Q000188:drug therapy*; D005834:Genital Neoplasms, Male / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D007278:Injections, Spinal; D008161:Lumbosacral Region; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D010388:Pelvis
D009020:Morphine