Murine leukemia L1210 cell lines with different patterns of resistance to platinum coordination complexes.
A murine leukemia L1210 cell line has been developed that exhibits 30-fold resistance to 1,2-diaminocyclohexaneplatinum(II) analogs but retains sensitivity to cisplatin. This contrasts existing cell lines which exhibit the opposite pattern of resistance. Both cell lines retain their sensitivity to melphalan.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002460:Cell Line; D002945:Cisplatin / Q000494:pharmacology*; D004351:Drug Resistance; D007939:Leukemia L1210 / Q000188:drug therapy*; D008558:Melphalan / Q000494:pharmacology; D051379:Mice; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D014410:Tumor Stem Cell Assay
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D002945:Cisplatin; D008558:Melphalan