[Nonspecific oxidase activity in the liver of rats undergoing chemotherapy with cis-dichlorodiammineplatinum].
A combined administration of cis-dichlorodiaminoplatinum (DDP) and phenobarbital increases the activity of nonspecific oxidases, decreases the toxic effect of DDP especially its nephrotoxic action, but does not decrease the antiblastic action of DDP in rats. On the basis of experimental data the optimum regime of DDP repeated administrations is suggested.
D000818:Animals; D002945:Cisplatin / Q000627:therapeutic use* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004790:Enzyme Induction / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000201:enzymology; D010088:Oxidoreductases / Q000378:metabolism*; D010634:Phenobarbital / Q000627:therapeutic use; D051381:Rats
D010088:Oxidoreductases; D002945:Cisplatin; D010634:Phenobarbital
Aktivnost' nespetsificheskikh oksidaz pecheni krys pri khimioterapii tsis-dikhlordiaminoplatinoĭ.