A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.
Four human complement genes, which have previously been mapped between HLA-D and HLA-B on chromosome 6, have now been aligned on a 98-kilobase (kb) section of the chromosome on the basis of four overlapping cosmid clones of genomic DNA. The C2 and factor B genes, less than 2 kb apart, are about 30 kb from two C4 genes separated from each other by about 10 kb.
D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D003175:Complement C2 / Q000235:genetics*; D003181:Complement C4 / Q000235:genetics*; D011415:Complement Factor B / Q000235:genetics*; D004792:Enzyme Precursors / Q000235:genetics*; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D008285:Major Histocompatibility Complex
D003175:Complement C2; D003181:Complement C4; D004792:Enzyme Precursors; D011415:Complement Factor B