Renal pelvic and ureteral dilatation in male rats ingesting trisodium nitrilotriacetate.
Renal pelvic and proximal ureteral dilatation has been observed in male Charles River (CD) and Fischer 344 rats ingesting comparable doses of Na3NTA X H2O. Ureteral dilatation is accompanied by epithelial surface ulceration and erosion. Taken together with previous work (Anderson, Alden & Merski, Fd Chem. Toxic. 1982, 20, 105), these findings demonstrate that the ingestion of high doses of NTA results in similar effects on the transitional epithelium throughout the urinary tract.
D000085:Acetates / Q000633:toxicity*; D000818:Animals; D004108:Dilatation, Pathologic / Q000139:chemically induced; D006869:Hydronephrosis / Q000139:chemically induced / Q000473:pathology; D007682:Kidney Pelvis / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009571:Nitrilotriacetic Acid / Q000633:toxicity*; D011859:Radiography; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D014513:Ureter / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology
D000085:Acetates; D009571:Nitrilotriacetic Acid