Regulatory effect of contraceptive steroids on the release of tissue-type plasminogen activator in vitro.
The release of tissue-type plasminogen activator (t-PA) from incubated specimens of human veins was investigated by an immunoradiometric determination of the concentration of t-PA in the medium. The initial release of t-PA was strongly correlated to the weight of the incubated specimens. T-PA was not demonstrable after the third day of incubation. The addition of d-norgestrel (83.3 ng/ml) to the medium significantly stimulated the release of t-PA; whereas, ethinylestradiol (16.6 ng/ml) did not have an effect.
D000328:Adult; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009644:Norgestrel / Q000494:pharmacology*; D010960:Plasminogen Activators / Q000378:metabolism*; D014680:Veins / Q000187:drug effects / Q000201:enzymology
D009644:Norgestrel; D004997:Ethinyl Estradiol; D010960:Plasminogen Activators