Diurnal rhythms in the liver hexokinase and glucokinase activity, in the level of glycogen in liver, skeletal and heart muscles and in the level of blood glucose in laboratory mice.
The experiments were carried out on 84 male Swiss mice. The first group was kept in light-dark conditions L:D = 6:18 and the second one--in reversed photoperiod--L:D = 18:6. After 6 weeks of the experiment the level of glucose in blood, the activity of hexokinase and glucokinase, and the summary activity of these enzymes in the liver, the concentration of glycogen in the liver, myocardium and gastrocnemius muscle were determined. A diurnal rhythm in the level of blood glucose was observed in L:D = 6:18. The rhythm of hexokinase and glucokinase activity in the liver was detected neither under conditions of L:D = 6:18 nor in L:D = 18:6. A diurnal rhythm of the summary activity of hexokinase and glucokinase in the liver was detected in L:D = 6:18. The diurnal rhythm of the level of glycogen in the liver and gastrocnemius muscle was observed in both types of photoperiod. In the myocardium the rhythm was detected neither under L:D = 6:18 nor L:D = 18:6 conditions.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002940:Circadian Rhythm; D005941:Glucokinase / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism*; D006593:Hexokinase / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D051379:Mice; D009132:Muscles / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D009928:Organ Specificity
D001786:Blood Glucose; D008112:Liver Glycogen; D006003:Glycogen; D006593:Hexokinase; D005941:Glucokinase