Protective effect of nifedipine upon digitalis intoxication.
Protective action of nifedipine (Bay a 1040, Adalat) in cardiac arrhythmias was tested in digitalis-intoxicated cats. Animals of both sexes weighing from 1.4 to 3.2 kg were anesthetized with sodium pentobarbital (35 mg/kg i.p.) heparinized (500 U/kg i.v.) and mechanically ventilated. Mean intracarotid blood pressure and heart rate were recorded. Two study groups were compared with a control group. Group I (N = 19): nifedipine (6.25; 12.50 or 25 micrograms/kg/min) was given in a 10-min infusion into the femoral vein of the cat, before a fast intravenous injection of lanatoside C (0.15 mg/kg). Group II (N = 19): cats intoxicated with lanatoside C were treated with nifedipine in the same doses and conditions described for Group I. The calcium antagonist was administered as soon as cardiac arrhythmias appeared. Control group (N = 10): lanatoside C was given as the only drug. In each group the observation period was maintained from 60 to 180 min after the administration of the last drug (nifedipine or lanatoside C). Results showed that pre-treatment with nifedipine inhibited digitalis arrhythmias in 10 out of 19 cats and prevented death in the majority of cases (16 out of 19). When given after lanatoside C, nifedipine was unable to suppress cardiac arrhythmias but improved the survival rate (8 out of 19). In lethal cases, the time of death of nifedipine-treated animals was earlier compared with the control group (p less than 0.05). It is concluded that nifedipine prevents and, in a minor proportion, protects from the toxic effects of digitalis.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004071:Digitalis Glycosides / Q000506:poisoning*; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D007799:Lanatosides / Q000494:pharmacology; D008297:Male; D009543:Nifedipine / Q000627:therapeutic use*; D013997:Time Factors; D014693:Ventricular Fibrillation / Q000517:prevention & control
D004071:Digitalis Glycosides; D007799:Lanatosides; C018548:lanatoside C; D009543:Nifedipine