The role of fibrinolytic enzymes in inflammation and paranasal mucous membrane.
The distribution and role of tissue plasminogen activator (TA) and proactivator (PA) in various diseases of the nasal and paranasal cavity were investigated. The stronger the inflammatory and proliferative response of the paranasal mucous membrane, the weaker was the fibrinolytic activity of TA. The fibrinolytic activity of PA tended to be stronger than TA activity. It is considered that PA may play an important role in inflammatory enlargement and proliferation of the paranasal mucous membrane, but does not play an important role in carcinogenic enlargement and proliferation of the nasal and paranasal mucous membrane.
D004792:Enzyme Precursors / Q000378:metabolism / Q000502:physiology*; D005342:Fibrinolysis; D006801:Humans; D009297:Nasal Mucosa / Q000201:enzymology*; D010254:Paranasal Sinus Diseases / Q000201:enzymology*; D010960:Plasminogen Activators / Q000378:metabolism / Q000502:physiology*; D012852:Sinusitis / Q000201:enzymology*
D004792:Enzyme Precursors; C011074:plasminogen proactivator; D010960:Plasminogen Activators