Death in sheep following dosing with copper diethylamine oxyquinoline sulphonate as a commercial injectable copper preparation.
Death occurred in sheep following diethylamine oxyquinoline sulphonate (DOS) copper injections given at recommended dose rates. The copper content in unused portions of DOS copper packs was normal and free of bacterial contamination. Liver and blood copper levels in dead and sick sheep were not high. Sick sheep showed signs of hepatic encephalopathy and dead sheep were generally piled against fences and scrub. Deaths were associated with acute, severe, generalised, centrilobular, hepatocellular necrosis and live sheep had elevated circulating levels of liver enzymes consistent with liver damage. In recovered sheep there were no residual complications. It would appear that even at 0.5 mg/kg of DOS copper the safety threshold may sometimes be exceeded in some sheep.
D000818:Animals; D001315:Australia; D002417:Cattle; D002614:Chelating Agents / Q000506:poisoning; D003035:Cobalt / Q000627:therapeutic use; D003300:Copper / Q000378:metabolism / Q000506:poisoning* / Q000627:therapeutic use; D004338:Drug Combinations / Q000627:therapeutic use; D006501:Hepatic Encephalopathy / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D008099:Liver / Q000187:drug effects*; D009942:Organometallic Compounds; D011804:Quinolines / Q000506:poisoning* / Q000627:therapeutic use; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced* / Q000473:pathology
D002614:Chelating Agents; D004338:Drug Combinations; D009942:Organometallic Compounds; D011804:Quinolines; C033773:copper diethylamine oxyquinoline sulfonate; D003035:Cobalt; D003300:Copper