Effect of the binding of anti-Zwa antibodies on platelet function.
Anti-Zwa antibodies can induce a Glanzmann-like platelet dysfunction in normal Zwa-positive platelets. Although a normal shape change and release reaction was always recorded in response to adenosine diphosphate and collagen, the aggregation on these inducers could be completely inhibited by anti-Zwa antibodies. Analogous to the platelets from patients with Glanzmann's thrombasthenia, normal platelets sensitized with anti-Zwa did not associate with fibrinogen upon exposure to adenosine diphosphate. Our data indicate that the binding site for fibrinogen is closely associated with the Zwa-antigenic determinants on the platelet membrane glycoproteins and thus with glycoprotein IIIa which is known to carry Zwa.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D016824:Antigens, Human Platelet; D001792:Blood Platelets / Q000276:immunology / Q000502:physiology*; D003018:Clot Retraction; D003094:Collagen / Q000494:pharmacology; D005260:Female; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D007231:Infant, Newborn; D039661:Integrin beta3; D007518:Isoantibodies / Q000276:immunology*; D007519:Isoantigens / Q000276:immunology*; D007700:Kinetics; D010974:Platelet Aggregation / Q000187:drug effects; D012701:Serotonin / Q000097:blood; D013921:Thrombocytopenia / Q000276:immunology / Q000503:physiopathology*
D016824:Antigens, Human Platelet; C061248:ITGB3 protein, human; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D039661:Integrin beta3; D007518:Isoantibodies; D007519:Isoantigens; D012701:Serotonin; D000244:Adenosine Diphosphate; D003094:Collagen