[Pharmacokinetics of a fluoride-calcium preparation for the treatment of osteoporosis].
The pharmacokinetics of fluoride and calcium were studied after administration of a combined fluoride and calcium preparation (Tridin) (1, 2 and 3 tablets) in 9 healthy male volunteers, using a cross-over study design. The total estimation of the pharmacokinetic data was performed by a simultaneous curve fitting to all single values, using a direct search procedure based on an open two-compartment model and three-compartment model, respectively. Maximum plasma concentrations and areas under the curve are proportional to the dose administered. Inter-subject variations are comparatively small, computerized multiple dose simulation for 3 days does not show any cumulation. The data fit the two-compartment model and the three-compartment model as well. The behaviour of the calcium concentrations reflects the immediate response of calcium homeostasis: plasma calcium concentrations are not affected.
D000328:Adult; D002118:Calcium / Q000378:metabolism* / Q000627:therapeutic use; D004338:Drug Combinations / Q000378:metabolism / Q000627:therapeutic use; D005459:Fluorides / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D007700:Kinetics; D008297:Male; D010024:Osteoporosis / Q000188:drug therapy*; D013997:Time Factors
D004338:Drug Combinations; C043342:tridin; D005459:Fluorides; D002118:Calcium
Pharmakokinetik eines Fluorid-Kalzium-Präparates zur Behandlung der Osteoporose.