Urinary excretion of the N-acetyl cysteine conjugate of cis-1,3-dichloropropene by exposed individuals.
A gas chromatographic-mass spectrometric assay was developed to identify and measure the N-acetyl cysteine conjugate of cis-1,3-dichloropropene. The assay was used to show that individuals exposed to 1,3-dichloropropene vapor during field applications excrete this conjugate in their urine. The recoveries of the conjugate were correlated with the product of airborne concentrations and the duration of exposure (r = 0.83).
D000042:Absorption; D000111:Acetylcysteine / Q000031:analogs & derivatives* / Q000652:urine; D000395:Air Pollutants, Occupational / Q000032:analysis*; D000498:Allyl Compounds / Q000378:metabolism*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D006843:Hydrocarbons, Chlorinated; D008297:Male
D000395:Air Pollutants, Occupational; D000498:Allyl Compounds; D006843:Hydrocarbons, Chlorinated; C042828:N-acetyl-S-(3-chloroprop-2-enyl)cysteine; C023891:1,3-dichloro-1-propene; D000111:Acetylcysteine