Unit responses at cochlear nucleus to electrical stimulation through a cochlear prosthesis.
Afferent auditory fibers of the guinea pig cochlea were electrically stimulated with current introduced through electrodes in the scala tympani. Thresholds were determined for unit responses recorded in the ventral cochlear nuclei to a sinusoid of 98 Hz from response-rate growth functions versus stimulus intensity. Suprathreshold response rates for most units grew rapidly from threshold to saturation at 2-15 dB above threshold. Peristimulus time histograms were collected for responses to single sinusoids and combinations of two and five sinusoids ranging from 86 to 134 Hz. Spike occurrences were highly synchronous with individual cycles of the pure sinusoids, but responses to the more complex waveforms occurred primarily to the more intense peaks. The amplitude envelope was thus a major contributor to responses to multiple sinusoids. Destruction of cochlear structures with neomycin increased unit thresholds and produced some changes in waveform encoding.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001309:Auditory Threshold / Q000187:drug effects; D003051:Cochlea / Q000187:drug effects / Q000502:physiology*; D003054:Cochlear Implants; D004558:Electric Stimulation; D006168:Guinea Pigs; D009355:Neomycin / Q000494:pharmacology
D009355:Neomycin