Effects of carbamazepine or imipramine alone or in association with amphetamine on the fighting time of REM sleep-deprived rats.
The fighting time of REM sleep-deprived rats was measured after both acute and long-term intraperitoneal treatment with carbamazepine (CBZ) or imipramine (IMI) alone or associated with amphetamine. Fighting time was increased by the lower doses of CBZ (5-20 mg/kg) or IMI (0.5-2 mg/kg) administered acutely. At the highest dose tested, CBZ (40 mg/kg) was not significantly different from the control value, and the fighting time observed after 4 mg/kg IMI was less than that observed with 2 mg/kg. Amphetamine (2 mg/kg) alone increased the fighting time and this effect was not modified by association with 5-40 mg/kg CBZ or 0.5-4 mg/kg IMI. Long-term treatment (14 days) with CBZ (20 mg kg-1 day-1) or IMI (2 mg kg-1 day-1) significantly reduced fighting time in contrast to the increase observed with a single acute treatment at the same dose. The fighting time of rats acutely treated with amphetamine (2 mg/kg) was significantly but not completely reduced by previous long-term pretreatment with CBZ, whereas IMI pretreatment had no effect. The differences between the effects of acute and long-term treatment with CBZ cannot be explained by the development of metabolic tolerance, since serum CBZ levels were the same in both situations.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D002220:Carbamazepine / Q000097:blood / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology*; D006801:Humans; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012892:Sleep Deprivation
D002220:Carbamazepine; D007099:Imipramine; D003913:Dextroamphetamine