title: Vitamin D conversion by sarcoid lymph node homogenate.
abstract: Recent studies suggest that hypercalcemia of sarcoidosis is due to high blood concentrations of calcitriol and that this compound may be synthesized at an extra-renal site. We report that sarcoid lymph node homogenate metabolized calcifediol to a substance indistinguishable from calcitriol, whereas six nonsarcoid lymph nodes failed to produce this compound.
mesh_terms: D002112:Calcifediol / Q000378:metabolism; D002117:Calcitriol / Q000378:metabolism; D004100:Dihydroxycholecalciferols / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008198:Lymph Nodes / Q000378:metabolism*; D008206:Lymphatic Diseases / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000378:metabolism*; D014807:Vitamin D / Q000378:metabolism*
chemical_list: D004100:Dihydroxycholecalciferols; D014807:Vitamin D; D002117:Calcitriol; D002112:Calcifediol; C026032:25,26-dihydroxycholecalciferol