title: Differences in the control of virus mRNA splicing during permissive or abortive infection with influenza A (fowl plague) virus.
abstract: Spliced transcripts of influenza A (fowl plague) virus (FPV) RNA (vRNA) segments 7 and 8 accumulate to a much greater extent during non-productive infection of mouse L cells, than they do during productive infection in primary chick embryo fibroblasts (CEF). Virus-specific protein synthesis, or a consequent event in virus replication appears necessary to promote splicing of vRNA segment 8-encoded mRNAs in both cell types, and of vRNA segment 7-encoded mRNAs in CEF. In L cells, however, splicing of the segment 7-encoded mRNAs seems to be independent of such virus-specific control. This observation is discussed in relation to the defect in expression of vRNA 7 which has been observed previously in FPV-infected L cells, and which is thought to account for the failure of virus replication.
mesh_terms: D000818:Animals; D002642:Chick Embryo; D004247:DNA / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D005786:Gene Expression Regulation; D009980:Influenza A virus / Q000235:genetics*; D007739:L Cells / Q000382:microbiology; D051379:Mice; D009693:Nucleic Acid Hybridization; D010455:Peptides / Q000235:genetics; D012326:RNA Splicing; D012367:RNA, Viral / Q000235:genetics*; D014764:Viral Proteins / Q000096:biosynthesis; D014776:Virus Cultivation; D014779:Virus Replication
chemical_list: D004279:DNA, Viral; D010455:Peptides; D012367:RNA, Viral; D014764:Viral Proteins; D004247:DNA