Human maximization testing of D&C Yellow no. 10 and Yellow no. 11.
By the maximization test, using 0.5% D&C Yellow no. 11 in pet., 15 of 20 human volunteers became contact sensitized. All reacted to a challenge concentration of 1000 ppm and one down to 1 ppm. The high allergenic potential of this dyestuff was confirmed. There were no cross reactions to purified samples of D&C Yellow no. 10. In contrast, 5% solutions of pure D&C Yellow no. 10 failed to sensitize human subjects. Cross reactions to this substance in persons sensitized to D&C Yellow no. 11 are due to impurities.
D000293:Adolescent; D000328:Adult; D004396:Coloring Agents / Q000633:toxicity*; D003877:Dermatitis, Contact / Q000209:etiology* / Q000276:immunology; D006801:Humans; D011804:Quinolines / Q000633:toxicity*; D012882:Skin Tests
D004396:Coloring Agents; D011804:Quinolines; C019303:quinoline yellow; C027012:2-((2'-quinolinyl)-1,3-indandione)