[Effect of repeated haloperidol and apomorphine administration on the development of tolerance for catalepsy and dopamine receptor hypersensitivity in mice].
It has been shown in experiments on mice that repeated administration of haloperidol (20 days) in doses of 0.1 and 5.0 mg/kg provoked an increase in the tolerance to the drug cataleptic effect. When administered in a higher dose (5.0 mg/kg), the drug increased 3H-spiroperidol binding with the striatal membranes 72 hours after withdrawal. Repeated administration of apomorphine in doses of 0.1 and 1 mg/kg combined with haloperidol antagonized the development of the tolerance and reduced the hypersensitivity of dopamine receptors, observed after withdrawal of haloperidol in a dose of 5.0 mg/kg. The low apomorphine dose also potentiated the haloperidol-induced catalepsy.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D002375:Catalepsy / Q000139:chemically induced*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D004361:Drug Tolerance; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D011954:Receptors, Dopamine / Q000187:drug effects*; D013134:Spiperone / Q000378:metabolism; D013997:Time Factors
D011954:Receptors, Dopamine; D013134:Spiperone; D006220:Haloperidol; D001058:Apomorphine
Vliianie povtornogo vvedeniia galoperidola s apomorfinom na vyrabotku tolerantnosti k katalepsii i giperchuvstvitel'nosti dofaminovykh retseptorov u mysheĭ.