title: 'ZSTATS'--a statistical analysis for potential Z-DNA sequences.
abstract: We have developed a FORTRAN programme for scanning DNA sequences for potential Z-DNA forming regions using the One-Sample Runs Test. The programme also detects other non-random arrangements of purines and pyrimidines on the same strand and will detect purine- or pyrimidine-rich strands and G:C- or A:T-rich regions. A series of test statistics are produced as a graphical output and these have been used to search a number of beta- type globin DNA sequences for potential Z-DNA regions whose biological significance is briefly discussed.
mesh_terms: D000328:Adult; D001482:Base Composition; D001483:Base Sequence; D003201:Computers; D004247:DNA / Q000235:genetics*; D004622:Embryo, Mammalian; D005260:Female; D005914:Globins / Q000235:genetics*; D006801:Humans; D008722:Methods; D008838:Microcomputers; D009690:Nucleic Acid Conformation; D011247:Pregnancy; D012984:Software
chemical_list: D005914:Globins; D004247:DNA