title: Gas chromatographic and gas chromatographic-mass spectrometric analysis of organic acids in plasma of patients with chronic renal failure.
abstract: Apart from increased concentrations of aliphatic dicarboxylic acids and phenolic aromatic acids in plasma from patients with chronic renal failure, there is large elevation of a furanoid acid, 3-carboxy-4-methyl-5-propyl-2- furanpropionic acid, and of hippuric acid. The levels of 3-hydroxy- and 4- hydroxyhippuric acid are also raised. The quantitative results are as follows: furanoid acid in hemodialysis patients, 1.4 +/- 0.6 mg/dl; in healthy individuals, 0.2 +/- 0.1 mg/dl; hippuric acid in hemodialysis patients, 9.8 +/- 6.5 mg/dl; in health individuals, 0.4 +/- 0.5 mg/dl. Both compounds are dialysable, but less effectively than creatinine and urea. The mean elimination rate of the furanoid acid is only 21%.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002264:Carboxylic Acids / Q000097:blood*; D002849:Chromatography, Gas / Q000379:methods; D005260:Female; D005663:Furans; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006626:Hippurates / Q000097:blood*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011422:Propionates / Q000097:blood*; D006435:Renal Dialysis
chemical_list: D002264:Carboxylic Acids; D005663:Furans; D006626:Hippurates; D011422:Propionates; C041693:3-carboxy-4-methyl-5-propyl-2-furanpropionic acid; C030514:hippuric acid