title: Lymphosarcoma and associated immune-mediated hemolytic anemia and thrombocytopenia in horses.
abstract: Three horses with equine lymphosarcoma were examined because of clinical signs including chronic weight loss, respiratory distress, peripheral edema, and chronic colic. Clinicopathologic findings included evidence of an immune-mediated hemolytic anemia. Immune-mediated thrombocytopenia also was diagnosed in 1 of the horses and suspected in another. One horse died in spite of treatment, 1 died 5 hours after surgical removal of a tumor encircling the jejunum, and 1 was euthanatized because of deteriorating condition. Necropsy of each horse revealed extensive neoplastic infiltration of peripheral lymph nodes and abdominal or thoracic viscera with neoplastic lymphocytes.
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications / Q000662:veterinary*; D000818:Animals; D001327:Autoimmune Diseases / Q000150:complications / Q000662:veterinary*; D005260:Female; D006734:Horse Diseases; D006736:Horses; D007414:Intestinal Neoplasms / Q000150:complications / Q000662:veterinary*; D008207:Lymphatic Metastasis; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000556:secondary / Q000662:veterinary*; D008297:Male; D011247:Pregnancy; D013921:Thrombocytopenia / Q000150:complications / Q000662:veterinary*