Ultrastructural study of lysosomes in the myocardium of spontaneously hypertensive rats under chronic salt ingestion.
The presence of lysosomes and lysosomal-like bodies in the myocardium of spontaneously hypertensive rats (SHRs) under the influence of 1% NaCl was studied. In SHRs, 2 weeks and older, there was an observable increase of lysosomes and lysosomal-like bodies in the myocardium when compared to the myocardium of age-matched controls. It is postulated that degradation is initiated by primary lysosomes and that mitochondria seem to be a prime target. The degradation process is also believed to be a relevant factor in cardiac hypertrophy of SHRs and that a high NaCl intake coupled with a sustained high blood pressure enhanced this process.
D000818:Animals; D005260:Female; D006321:Heart / Q000187:drug effects; D006973:Hypertension / Q000473:pathology*; D008247:Lysosomes / Q000187:drug effects / Q000648:ultrastructure*; D008297:Male; D008854:Microscopy, Electron; D008929:Mitochondria, Heart / Q000648:ultrastructure; D009206:Myocardium / Q000648:ultrastructure*; D051381:Rats; D011918:Rats, Inbred SHR; D012965:Sodium Chloride / Q000494:pharmacology*
D012965:Sodium Chloride