title: [Antiemetic activity of dimetpramid].
abstract: It has been shown that dimethpramide, a new Soviet-made antiemetic belonging to the group of substituted benzamides, effectively prevents the emetic action of L-DOPA and apomorphine in dogs (the ED50 is 0.04 and 0.12 mg/kg, respectively). When given in doses of 10-25 mg/kg dimethpramide suppresses vomiting induced by adrenaline, histamine, strophanthine, sodium salicylate, and copper sulfate. The drug exerts a selective dopamine-blocking action on the receptors of the triggering zone of the vomiting center without producing any substantial action on the dopaminergic brain systems that regulate behavioral activity.
mesh_terms: D000818:Animals; D000932:Antiemetics / Q000494:pharmacology* / Q000627:therapeutic use; D001549:Benzamides / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced; D003214:Conditioning, Classical / Q000187:drug effects; D004285:Dogs; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008297:Male; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy
chemical_list: D000932:Antiemetics; D001549:Benzamides; D011954:Receptors, Dopamine; C037141:dimetpramid; D004298:Dopamine
vernacular_title: Issledovanie protivorvotnoĭ aktivnosti dimetpramida.