Distribution and excretion of a new insect repellent, 14C-DEM, in the mouse after intravenous, cutaneous, and oral administration.
The distribution of 14C after administration of 14C-DEM was qualitatively similar irrespective of the administration route (intravenous, cutaneous or oral). The major accumulation sites were lacrimal and nasal glands, parotis, liver, and kidney. The main excretion was through the urine and only minor quantities through the faeces and the expired gases. It could be confirmed that the new repellent had a low skin uptake.
D000081:Acetamides / Q000008:administration & dosage / Q000378:metabolism*; D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D001345:Autoradiography; D044482:Benzeneacetamides; D005260:Female; D007275:Injections, Intravenous; D007302:Insect Repellents / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy
D000081:Acetamides; D044482:Benzeneacetamides; D007302:Insect Repellents; C040575:2-hydroxy-2-phenyl-N,N-diethylacetamide