title: Calcospherites in pituitary prolactinomas. A hypothesis for their formation.
abstract: Calcospherites are being reported with increasing frequency in pituitary prolactinomas. Ultrastructural study of such a case, along with the recent characterization of the molecular composition of prolactin granules, has led us to hypothesize that a unique intracellular milieu exists in which calcification can be initiated and can proceed to calcospherite formation.
mesh_terms: D000328:Adult; D002113:Calcification, Physiologic; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D010911:Pituitary Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D011388:Prolactin / Q000378:metabolism*
chemical_list: D011388:Prolactin