Effect of a single dose of T3 on the incorporation of (Methyl-14C) methionine into phosphatidylcholine and lysophosphatidylcholine in chick liver.
The preliminary effect of a single dose of T3 (Triidothyronine) on the incorporation of (Methyl-14C) Methionine into liver phosphatidylcholine, lysophosphatidylcholine and methylated precursors was studied in chick liver from 0.25 to 6 hours. Chicks received a T3 dose intraperitoneally 5 h prior labeled compound administration. It can be deduced that the hormone effect is similar in phosphatidylcholine and lysophosphatidylcholine. In our conditions, the preliminary hormone effect is maximum 5 1/2 h after T3 injection. The levels of methylated precursors have been studied by radioactivity and lipid P determinations; these levels are constant throughout the time course experiment. We conclude that the increase in methyl group incorporation is due to a hormone-dependent increase in phospholipid turnover.
D000818:Animals; D002250:Carbon Radioisotopes; D002645:Chickens; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008244:Lysophosphatidylcholines / Q000096:biosynthesis*; D008715:Methionine / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000096:biosynthesis*; D014284:Triiodothyronine / Q000494:pharmacology*
D002250:Carbon Radioisotopes; D008244:Lysophosphatidylcholines; D010713:Phosphatidylcholines; D014284:Triiodothyronine; D008715:Methionine