A-16686, a new antibiotic from Actinoplanes. II. Biological properties.
A-16686, a new glycoproteide antibiotic obtained from fermentation of an Actinoplanes strain, is active against Gram-positive aerobic and anaerobic bacteria; MIC values ranged from 0.016 to 2.0 micrograms/ml. A-16686 is bactericidal for growing cells of Staphylococcus aureus, S. epidermidis, Streptococcus faecalis, S. faecium, S. mutans, S. mitis and S. sanguis. There is no cross-resistance with clinically used antibiotics. A-16686, administered subcutaneously, is very effective in experimental S. pyogenes and S. pneumoniae septicemias in the mouse.
D000667:Ampicillin / Q000633:toxicity; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D047630:Depsipeptides; D006020:Glycopeptides / Q000633:toxicity; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic; D013045:Species Specificity; D014640:Vancomycin / Q000633:toxicity
D000900:Anti-Bacterial Agents; D047630:Depsipeptides; D006020:Glycopeptides; D010456:Peptides, Cyclic; C041438:ramoplanin; D014640:Vancomycin; D000667:Ampicillin