[Role of the total and prolonged diversion of portal blood on hepatic function in the rat].
In this experience the effect on hepatic parenchyma and function has been analyzed 180 days after total portacaval shunt. The portacaval shunt induces 50% mortality rate at six months. In the survived animals a significant reduction of hepatic mass has been observed. The liver still presents significant elevation of necrosis and cholestasis enzymes. The residual hepatocellular function related to hepatic mass is comparable to sham operated rats, but it is quite insufficient to maintain endogenous clearances.
D000818:Animals; D008099:Liver / Q000473:pathology*; D008111:Liver Function Tests; D009336:Necrosis; D011167:Portacaval Shunt, Surgical / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains
Ruolo della derivazione totale e protratta del sangue portale sulla funzionalita' epatica nel ratto.