Vaginal absorption of oestradiol and progesterone.
The vaginal absorption of micronized oestradiol/progesterone from a hydrophilic matrix system was investigated before and after 10 days of treatment in 7 post-menopausal women with an average age of 56.1 yr. Oestradiol and progesterone levels were measured on days 1 and 11 before administration and 0.5, 1, 2, 3, 4, 6, 8, 12, and 24 h afterwards by radioimmunoassay. Peak values were seen 6-12 h after administration. This finding differs from those of other investigations. Sex hormone binding globulin (SHBG) and androgen concentrations were unchanged after 10 days of treatment.
D000728:Androgens / Q000097:blood; D004958:Estradiol / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D011374:Progesterone / Q000008:administration & dosage / Q000378:metabolism*; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism; D013488:Suppositories; D013997:Time Factors; D014621:Vagina / Q000378:metabolism*
D000728:Androgens; D012738:Sex Hormone-Binding Globulin; D013488:Suppositories; D011374:Progesterone; D004958:Estradiol