The growth and spontaneous dissemination of melanoma B16 and Lewis lung tumour in two sub-strains of C57BL/6J mice treated with Corynebacterium parvum and/or levamisole.
The effect of C. parvum and/or levamisole on tumour growth and spontaneous dissemination was tested in two tumour-host systems, melanoma B16 and LLT in C57BL/6J mice. C. parvum inhibited the growth of LLT and its dissemination to the lungs and the growth of B16 in females in one of the two sub-strains of mice used. Levamisole stimulated the growth of B16 in females in one sub-strain and in both sexes in the other sub-strain of mice. The growth of LLT was not influenced by levamisole but its dissemination to lymph nodes was facilitated. The growth-stimulating effect of levamisole was abrogated by C. parvum in the mice treated with both agents in combination. It is concluded that the effects of non-specific immunomodulators on tumour growth and spread can vary between sub-strains of the same inbred strain of mice bred at different laboratories.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D005260:Female; D007978:Levamisole / Q000627:therapeutic use*; D008175:Lung Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D008207:Lymphatic Metastasis; D008297:Male; D008545:Melanoma / Q000473:pathology / Q000556:secondary* / Q000601:surgery / Q000628:therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D011425:Propionibacterium acnes
D000276:Adjuvants, Immunologic; D007978:Levamisole