Effect of acute chloroquine treatment on prostaglandin- and gonadotropin-stimulated testosterone secretion of rat testis.
The effect of chloroquine injection to rats on in vitro-testosterone secretion stimulated by human chorionic gonadotropin (hCG) and prostaglandin E1 (PGE1) was studied. Rats were injected for 5 days with chloroquine phosphate. Testosterone secretion was stimulated by hCG or PGE1 for 3 h in the removed testis and was measured by radioimmunoassay. Chloroquine treatment in vivo does not seem to have any demonstrable effect on testosterone secretion stimulated by hCG or PGE 1 in prepubertal as well as in the postpubertal rats. However, in pubertal rats chloroquine treatment inhibited testosterone secretion in hCG-stimulated testis.
D000375:Aging; D000527:Alprostadil; D000818:Animals; D002738:Chloroquine / Q000494:pharmacology*; D006063:Chorionic Gonadotropin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000187:drug effects* / Q000378:metabolism; D013739:Testosterone / Q000378:metabolism*
D006063:Chorionic Gonadotropin; D011458:Prostaglandins E; D013739:Testosterone; D002738:Chloroquine; D000527:Alprostadil