Open meniscectomy: enhanced recovery after synovial prostaglandin inhibition.
The suppression of the immediate postmeniscectomy synovial reaction by a potent prostaglandin inhibitor (flurbiprofen 400 mg daily) resulted in significantly less knee pain and swelling in 50 patients compared to 50 age-matched controls taking a simple analgesic (paracetamol 4 g daily) (P less than 0.001), thus enhancing recovery by three to four weeks. In the patients undergoing partial meniscectomy knee function was restored by 27 days, a figure comparable with endoscopic methods.
D000082:Acetaminophen / Q000627:therapeutic use; D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D005480:Flurbiprofen / Q000627:therapeutic use*; D006801:Humans; D007719:Knee Joint / Q000503:physiopathology; D008297:Male; D008592:Menisci, Tibial / Q000601:surgery*; D008875:Middle Aged; D009132:Muscles / Q000503:physiopathology; D011183:Postoperative Complications / Q000517:prevention & control; D011422:Propionates / Q000627:therapeutic use*; D011448:Prostaglandin Antagonists / Q000627:therapeutic use*; D013582:Synovial Fluid / Q000378:metabolism; D013585:Synovitis / Q000517:prevention & control*; D013997:Time Factors
D011422:Propionates; D011448:Prostaglandin Antagonists; D000082:Acetaminophen; D005480:Flurbiprofen