Prevention of TCDD toxicity in laboratory rodents by addition of charcoal or cholic acids to chow.
The mortalities of mice, rats and guinea-pigs given a single lethal dose of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) were substantially reduced by feeding them with chows containing 2.5 or 5% activated charcoal, which presumably enhances elimination of the toxic agent from the organism. Chows with 0.25 or 0.5% cholic acid and dehydrocholic acid added had a similar protective action on mice intoxicated with TCDD. Since no treatment is currently available for this type of poisoning, charcoal-whose safe clinical use is well established-is worth considering in view of its potential benefit to humans acutely exposed to TCDD.
D000821:Animal Feed; D000818:Animals; D002606:Charcoal / Q000494:pharmacology*; D019826:Cholic Acid; D002793:Cholic Acids / Q000494:pharmacology*; D003685:Dehydrocholic Acid / Q000494:pharmacology; D004147:Dioxins / Q000037:antagonists & inhibitors*; D006168:Guinea Pigs; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D010243:Paralysis / Q000139:chemically induced; D000072317:Polychlorinated Dibenzodioxins / Q000037:antagonists & inhibitors* / Q000378:metabolism / Q000633:toxicity; D051381:Rats; D015049:Zoxazolamine / Q000378:metabolism / Q000494:pharmacology
D002793:Cholic Acids; D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D002606:Charcoal; D015049:Zoxazolamine; D019826:Cholic Acid; D003685:Dehydrocholic Acid