Casomorphins reduce separation distress in chicks.
Intraventricular administration of various chain length casomorphins (CM) reliably reduced separation induced distress vocalizations (DVs) in young domestic chicks. At a dose of 50 nanomoles, CM-5 was more potent than either CM-4 or CM-7, but for each the duration of action was approximately half an hour, with CM-7 having a somewhat longer effect. This suppression of DVs was partially antagonized by naloxone (1 mg/kg).
D000818:Animals; D001010:Anxiety, Separation / Q000188:drug therapy*; D002552:Cerebral Ventricles / Q000187:drug effects; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D010446:Peptide Fragments; D013329:Structure-Activity Relationship; D014828:Vocalization, Animal / Q000187:drug effects
D004723:Endorphins; D010446:Peptide Fragments; D009270:Naloxone; C041128:beta-casomorphin 7; C034812:beta-casomorphin 5; C043158:beta-casomorphin 4; C021968:beta-casomorphins