A routine fitting of kinetic data to sums of exponentials with a programmable calculator.
The effects of prolonged ingestion of ethyl alcohol on the elimination kinetics of bromsulphalein (BSP) from the plasma and the excretion of the dye into bile after a single intravenous injection into the circulation of the rat were examined by means of the colorimetrical technique. Simple numerical methods for fitting the experimental data to polyexponential and convex upward functions were also proposed. Two multioptional programs written for the Texas Instrument 59 programmable calculator and for the Sharp 1500 pocket computer were developed which provide for fully automated exponential stripping of pharmacokinetic data and which will allow workers to calculate the numerical values of all the coefficients and exponents for the tracer function fitting the monotone sequences of data.
D000428:Alcohol Drinking; D000818:Animals; D001646:Bile / Q000378:metabolism; D003201:Computers; D000431:Ethanol / Q000097:blood; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008657:Metabolic Clearance Rate; D051381:Rats; D011919:Rats, Inbred Strains; D012984:Software; D013448:Sulfobromophthalein / Q000378:metabolism*
D013448:Sulfobromophthalein; D000431:Ethanol