[Characteristics of the ultraslow activity and temperature of the brain as affected by neurotropic substances].
It has been demonstrated in experiments on rabbits with golden electrodes and thermocouples implanted to the brain that ethimizol (1.5 mg/kg) and 1-ethyl-4,5-di-(N.-methylcarbamoyl)-pyrazole (IEM-476, 3 mg/kg) altered the amplitude and frequency of ultraslow wave potentials and decreased the temperature of the hypothalamus, dorsal hippocamp and neocortex. Allylnorantifein (1-allyl-4,5-di-(N-methylcarbamoyl)-imidazole, 3 mg/kg) and 1-allyl-4,5-di-(N-methylcarbamoyl)-pyrazole (IEM-474, 3 mg/kg) altered the amplitude and frequency of ultraslow wave potentials of middle brain reticular formation nuclei, medial thalamic nuclei and of the neocortex, the structures of the nonspecific ascending system of the brain, and did not influence the temperature of the brain. The effects of IEM-476 and IEM-474 on the indicators under study were less powerful than those of ethimizol and allylnortifein.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D002415:Cats; D004567:Electrodes, Implanted; D004569:Electroencephalography; D005042:Etimizol / Q000031:analogs & derivatives / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D007273:Injections, Intramuscular; D011720:Pyrazoles
D007093:Imidazoles; D011720:Pyrazoles; C040800:1-ethyl-4,5-di(N-methylcarbamoyl)pyrazole; C042761:1-allyl-4,5-di(N-methylcarbamoyl)pyrazole; C042759:1-allylnorantifeine; D005042:Etimizol
Kharakteristika sverkhmedlennoĭ aktivnosti i temperatury mozga pri deĭstvii neĭrotropnykh veshchestv.