title: Prostaglandin E1 in suspected ductus dependent cardiac malformation.
abstract: Fifty two sick neonates with major duct dependent cardiac defects were given short term intravenous infusions of prostaglandin E1 (alprostadil) in doses varying between 0.005 and 0.1 micrograms/kg/minute. The object of the study was to try to achieve an effective but safe regiment that could be instituted as soon as such a diagnosis was suspected. Effective clinical improvement was achieved at each dosage but the incidence of side effects seemed to be dose related, and no serious side effects were noted at a dosage of 0.005 to 0.01 micrograms/kg/minute. It is recommended that a low dosage regimen be started before transfer to a paediatric cardiac centre.
mesh_terms: D000527:Alprostadil; D001049:Apnea / Q000139:chemically induced; D001775:Blood Circulation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004373:Ductus Arteriosus / Q000187:drug effects; D006330:Heart Defects, Congenital / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D007231:Infant, Newborn; D010100:Oxygen / Q000097:blood; D011458:Prostaglandins E / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D011652:Pulmonary Circulation / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced; D014665:Vasodilator Agents / Q000627:therapeutic use*
chemical_list: D011458:Prostaglandins E; D014665:Vasodilator Agents; D000527:Alprostadil; D010100:Oxygen