Efficacy in vivo of almagate in neutralising histamine-induced acid secretion in a rat re-perfused stomach preparation.
The efficacies of almagate (hydrated aluminium-magnesium hydroxycarbonate, Al2Mg6(OH)14(CO3)2 X 4H2O, Almax) and aluminium hydroxide to neutralise histamine-induced gastric acid hypersecretion were compared in a closed-circuit perfused stomach preparation modified for pH-stat titration in the intact, anaesthetised rat. After intravenous injection of histamine (0.75 mg/kg), the amount of antacid automatically added to the closed system to maintain the stomach perfusion fluid at pH 4 was measured during 60 min. The results obtained show that the acid neutralising capacity of almagate in this hypersecretion model was some 8 times greater than that of aluminium hydroxide. Analysis of the titration curves obtained also demonstrates that the velocity of neutralisation to pH 4 at the start of the experiment was considerably more rapid with almagate. It is concluded that almagate will be a rapid acting, potent drug to reduce acidity of the gastric contents in conditions of acid hypersecretion.
D000536:Aluminum Hydroxide / Q000494:pharmacology*; D000818:Animals; D000863:Antacids / Q000494:pharmacology*; D002254:Carbonates / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D006632:Histamine / Q000494:pharmacology; D006633:Histamine Antagonists; D008274:Magnesium / Q000494:pharmacology*; D008276:Magnesium Hydroxide / Q000494:pharmacology*; D008297:Male; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D000863:Antacids; D002254:Carbonates; D006633:Histamine Antagonists; C043698:almagate; D000536:Aluminum Hydroxide; D006632:Histamine; D008274:Magnesium; D008276:Magnesium Hydroxide