[Changes in the transmural electric potential difference in the region of stomach ulcer. Local effect of sucralfate, aluminum hydroxide and magnesium trisilicate].
In three groups of six patients with gastric ulcer, sucralfate, aluminium hydroxide and magnesium trisilicate, respectively was applied to the ulcer under endoscopic vision. Prior to, two and four hours after application of these substances, the transmural electrical potential difference (p.d.) was measured in the region of the bed of the ulcer, the margin of the ulcer, the antrum on the lesser curvature side, and in the pool of juice; additionally, the degree of adherence of the substances to the floor of the ulcer was recorded. After sucralfate, the increase in p.d. in the bed of the ulcer was clearly greater two and four hours post-application than after the two antacids tested, and adherence to the ulcer was also more marked and longer lasting. These findings confirm the superior local protective effect of sucralfate in the bed of the ulcer on the basis of its physico-chemical properties, as compared with the antacids tested. These clinico-experimental findings correlate with the efficacy of sucralfate in ulcer disease as demonstrated in clinical studies.
D000200:Action Potentials / Q000187:drug effects; D000287:Administration, Topical; D000535:Aluminum / Q000008:administration & dosage / Q000627:therapeutic use*; D000536:Aluminum Hydroxide / Q000008:administration & dosage / Q000627:therapeutic use; D000863:Antacids / Q000008:administration & dosage / Q000627:therapeutic use*; D005750:Gastric Juice / Q000187:drug effects; D005753:Gastric Mucosa / Q000187:drug effects / Q000503:physiopathology*; D005773:Gastroscopy; D006801:Humans; D008274:Magnesium / Q000008:administration & dosage / Q000627:therapeutic use; D017633:Magnesium Silicates; D012824:Silicic Acid / Q000008:administration & dosage / Q000627:therapeutic use; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000503:physiopathology; D013392:Sucralfate
D000863:Antacids; D017633:Magnesium Silicates; D012824:Silicic Acid; D013392:Sucralfate; D000536:Aluminum Hydroxide; C001671:magnesium trisilicate; D000535:Aluminum; D008274:Magnesium
Veränderungen der transmuralen elektrischen Potentialdifferenz im Bereich des Ulcus ventriculi. Eine Studie zur lokalen Wirkung von Sucralfat, Aluminium-Hydroxid und Magnesium-Trisilikat.