(+)-Catechin inhibits the invasion of malignant fibrosarcoma cells into chick heart in vitro.
(+)-Catechin, a flavonoid extractable from higher plants and trees, inhibits the invasion of malignant MO4 fibrosarcoma cells into embryonic chick heart fragments in vitro. This inhibition is maximal at a drug concentration of 0.5 mM. The growth of the MO4 cells is only partly inhibited at such a concentration, and the effect can hardly be ascribed to an irreversible cytotoxicity of the drug to the host tissue. Pretreatment of the host tissue with the drug seems to be a prerequisite for the inhibitory action, which suggests that the anti-invasive effect is at least partly mediated by the condition of the heart tissue. We hypothesize that the collagen-stabilizing effect of (+)-catechin is the key to the explanation of its anti-invasive properties.
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology*; D002449:Cell Aggregation; D002460:Cell Line; D002470:Cell Survival; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D002472:Cell Transformation, Viral; D002642:Chick Embryo; D005354:Fibrosarcoma / Q000473:pathology*; D006338:Heart Neoplasms / Q000473:pathology*; D006358:Hot Temperature; D051379:Mice; D008809:Mice, Inbred C3H; D009206:Myocardium / Q000473:pathology*; D009361:Neoplasm Invasiveness
D001578:Benzopyrans; D002392:Catechin