The anterior cingulate cortex and stress: effects of chlordiazepoxide on unit-activity and stimulation-induced gastric pathology in rats.
Multiple unit-activity in the anterior cingulate cortex of rats indicated that during immobilization-stress some units increased responding, and others decreased their response rates. Changes in unit-behavior were also found when a stimulus was presented that previously had been paired with the restraint treatment. Pretreatment with chlordiazepoxide prevented the stress-induced increases in unit-activity, whereas, suppressed units were not affected by the drug treatment. Injections of chlordiazepoxide also attenuated the gastric pathology which was found following low-level electrical stimulation of the area of the units which had been identified to respond to restraint-stress.
D000818:Animals; D002707:Chlordiazepoxide / Q000627:therapeutic use*; D004195:Disease Models, Animal; D006179:Gyrus Cinguli / Q000503:physiopathology*; D006801:Humans; D008297:Male; D011602:Psychophysiologic Disorders / Q000188:drug therapy / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013272:Stomach Diseases / Q000523:psychology*; D013315:Stress, Psychological / Q000188:drug therapy / Q000503:physiopathology*
D002707:Chlordiazepoxide