CTP can replace GTP in reactions catalyzed by eukaryotic peptide elongation factor 1.
In several reactions catalyzed by highly purified peptide elongation factor 1 from rabbit reticulocytes, GTP may be fully replaced by CTP but not by ATP or UTP. This holds true for the factor-dependent binding of aminoacyl-tRNA to ribosomes, GTPase activity, GTP-dependent autophosphorylation of the factor protein and binding of cholesteryl 14-methylhexadecanoate by the factor.
D000255:Adenosine Triphosphate / Q000378:metabolism; D003570:Cytidine Triphosphate / Q000378:metabolism*; D003597:Cytosine Nucleotides / Q000378:metabolism*; D006160:Guanosine Triphosphate / Q000378:metabolism*; D007700:Kinetics; D020648:Peptide Elongation Factor 1; D010445:Peptide Elongation Factors / Q000378:metabolism*; D010710:Phosphates / Q000378:metabolism; D011072:Poly U / Q000378:metabolism; D012346:RNA, Transfer, Amino Acyl / Q000378:metabolism; D014544:Uridine Triphosphate / Q000378:metabolism
D003597:Cytosine Nucleotides; D020648:Peptide Elongation Factor 1; D010445:Peptide Elongation Factors; D010710:Phosphates; D012346:RNA, Transfer, Amino Acyl; D011072:Poly U; D003570:Cytidine Triphosphate; D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate; D014544:Uridine Triphosphate