O-(beta-hydroxyethyl)-rutoside (Venoruton) fails to block histamine or bradykinin-induced edema formation in the canine forelimb perfused at constant arterial inflow.
O-(beta-hydroxyethyl)-rutoside (Venoruton) has been reported to alleviate edema formation in chronic venous insufficiency. In an attempt to elucidate Venoruton's potential as an antiinflammatory agent, we infused Venoruton (20 mg/minute) intraarterially into the canine forelimb perfused at constant flow during the simultaneous intraarterial infusion of histamine (4 micrograms base/minute) or bradykinin (2 micrograms/minute). The infusion of Venoruton alone for forty minutes resulted in a small but significant increase in forelimb arterial pressures but no change in systemic pressure or forelimb skin lymph flow, protein concentration or protein transport. Subsequent infusion of either histamine or bradykinin resulted in a significant decrease in forelimb arterial pressures and a marked increase in skin lymph flow, lymph total protein concentration and lymph total protein transport. The changes in forelimb vascular pressures and skin lymph parameters were similar to those seen during the infusion of either histamine or bradykinin alone. These data indicate that the intraarterial infusion of Venoruton at this dosage does not inhibit the ability of simultaneously infused histamine or bradykinin to increase transvascular fluid and macromolecular efflux in the canine forelimb perfused at constant arterial inflow.
D000818:Animals; D000893:Anti-Inflammatory Agents; D001794:Blood Pressure / Q000187:drug effects; D001920:Bradykinin; D002199:Capillary Permeability / Q000187:drug effects; D004285:Dogs; D004487:Edema / Q000139:chemically induced / Q000517:prevention & control*; D005260:Female; D005552:Forelimb; D006632:Histamine; D006896:Hydroxyethylrutoside / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D007261:Infusions, Intra-Arterial; D008196:Lymph / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010477:Perfusion; D011506:Proteins / Q000378:metabolism; D012431:Rutin / Q000031:analogs & derivatives*; D012867:Skin / Q000098:blood supply
D000893:Anti-Inflammatory Agents; D006896:Hydroxyethylrutoside; D011506:Proteins; D012431:Rutin; C005865:troxerutin; D006632:Histamine; D001920:Bradykinin