Evaluation of histological changes in the kidneys of the alloxan diabetic rat by means of factor analysis.
Renal histopathology data, obtained in a 3-month feeding study of the effects of different carbohydrates and polyols in the alloxan diabetic rat, have been subjected to factor analysis. The results indicate a primary and a secondary effect of the diabetic state on the kidney of the rat. The primary effect, the 'diabetes factor', was associated with hyperglycaemia and was responsible for dilatation of proximal and distal tubules in the cortex and the formation of dilated distal tubules with coarsely vacuolated, glycogen-containing epithelial cells. The secondary effect, named the 'individual response factor', was associated with inflammatory processes. In both males and females it included a 'degeneration factor' which manifested itself in an increased number of basophilic tubules and a thickening of basal laminae in the Bowman's capsules. In males it also involved a 'protein factor', which caused expansion of the mesangial matrix and the appearance of proximal tubules filled with eosinophilic material and lined with vacuolated epithelial cells. The analysis indicates that the kidneys of alloxan diabetic rats fed diets containing polyols were affected less than those of rats fed diets containing carbohydrates.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D004040:Dietary Carbohydrates / Q000494:pharmacology; D004108:Dilatation, Pathologic; D005163:Factor Analysis, Statistical; D005260:Female; D007668:Kidney / Q000473:pathology*; D007684:Kidney Tubules / Q000473:pathology; D008297:Male; D009393:Nephritis / Q000473:pathology; D009929:Organ Size; D010179:Pancreas / Q000473:pathology; D011506:Proteins / Q000378:metabolism; D051381:Rats; D012737:Sex Factors; D013402:Sugar Alcohols / Q000494:pharmacology
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D011506:Proteins; D013402:Sugar Alcohols