Inner and outer complexes of Pt-coordination compounds with DNA probed by SERS spectroscopy.
Surface enhanced Raman scattering (SERS) spectroscopy has been used to study the interfacial behaviour of DNA modified by cis-Pt(NH3)2Cl2, (cis-DDP) and [Pt-(dien)Cl]Cl bidentate and monodentate platinum coordination compounds, respectively. Two stereochemical configurations of Pt-DNA complexes can be deduced from the adsorption behaviour of the Pt adducts. The antitumoral inactive [Pt-(dien)Cl] Cl forms an outer complex whereas the antitumoral active cis-DDP favours an inner complex.
D002945:Cisplatin / Q000031:analogs & derivatives*; D004247:DNA; D008968:Molecular Conformation; D013059:Spectrum Analysis, Raman
C032799:chlorodiethylenetriamine platinum; D004247:DNA; D002945:Cisplatin