Comparative studies of the effects of some antimuscarinic agents on gastric damage and pupillary reflex in the rat.
The effects of some antimuscarinic compounds on oxotremorine-induced gastric damage, the pupil size and the pupillary light reflex have been studied in the rat. Unlike atropine, propantheline and methylscopolamine, pirenzepine is effective in preventing gastric erosions at doses much lower than those that affect pupillary reflex.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001570:Benzodiazepinones / Q000494:pharmacology; D005260:Female; D019832:N-Methylscopolamine; D010095:Oxotremorine / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology*; D010890:Pirenzepine; D011413:Propantheline / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012025:Reflex, Pupillary / Q000187:drug effects*; D012602:Scopolamine Derivatives / Q000494:pharmacology; D013272:Stomach Diseases / Q000139:chemically induced*
D001570:Benzodiazepinones; D010276:Parasympatholytics; D012602:Scopolamine Derivatives; D011413:Propantheline; D010890:Pirenzepine; D010095:Oxotremorine; D001285:Atropine; D019832:N-Methylscopolamine