Use of PKM-MULTI program for fitting discontinuous absorption profiles using a microcomputer.
The programs for the pharmacokinetic models with discontinuous absorption, written in BASIC, were connected to MULTI, which had been proposed for nonlinear least squares for a microcomputer by Yamaoka et al. Using this program (designated as PKM-MULTI), the same data sets previously calculated by HFCM, FITSI2 and NONLIN were fitted and the finally obtained estimates were in close agreement with those obtained previously. The plasma data of nalidixic acid were also fitted to the pharmacokinetic model with discontinuous absorption, which were suggested to be more valid compared with one compartment model with continuous absorption.
D001682:Biological Availability; D002026:Buformin / Q000378:metabolism; D003201:Computers; D006118:Griseofulvin / Q000378:metabolism; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D008838:Microcomputers; D008954:Models, Biological; D009268:Nalidixic Acid / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012984:Software; D013444:Sulfisoxazole / Q000378:metabolism
D004364:Pharmaceutical Preparations; D006118:Griseofulvin; D009268:Nalidixic Acid; D013444:Sulfisoxazole; D002026:Buformin