[Markerfunction of crosslinked fibrin derivatives in ascitic fluid from patients with ovarian cancer: a comparison with ascitic fluid in liver cirrhosis].
Ascitic fluid from patients with ovarian cancer contains high levels of fibrin(ogen) degradation products (FDP). Crosslinked fibrin derivatives were isolated by precipitation and separated by PAA-gel-electrophoresis. In order to evaluate the submolecular structure the total precipitate and single derivatives were investigated after cleavage of the disulfide bonds. The findings are related to the radioimmunological measurements of certain fibrinopeptides. Tumor ascites contains approximately ten times higher levels of crosslinked fibrin derivatives than cirrhosis ascites. The fibrinopeptide A content is similar, whereas the levels of plasmin-induced alpha-chain fragment are significantly higher in tumor ascites. The findings suggest a catabolism of fibrinogen in ascitic fluid via coagulation and fibrinolysis. In tumor ascites fibrinogen is catabolized to a significantly higher degree via the degradation of crosslinked fibrin. Crosslinked fibrin derivatives may therefore be usable as non-carcinoembryogenic tumor markers.
D001201:Ascites / Q000378:metabolism; D001202:Ascitic Fluid / Q000032:analysis*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis*; D005340:Fibrinogen / Q000378:metabolism; D005344:Fibrinopeptide A / Q000032:analysis; D006801:Humans; D008103:Liver Cirrhosis / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology*
D005338:Fibrin Fibrinogen Degradation Products; D005344:Fibrinopeptide A; D005340:Fibrinogen
Markerfunktion von quervernetzten Fibrinderivaten im Aszites beim Ovarialkarzinom: Ein Vergleich zu Aszites bei Leberzirrhose.