title: Renal pelvic and ureteral dilatation in male rats ingesting trisodium nitrilotriacetate.
abstract: Renal pelvic and proximal ureteral dilatation has been observed in male Charles River (CD) and Fischer 344 rats ingesting comparable doses of Na3NTA X H2O. Ureteral dilatation is accompanied by epithelial surface ulceration and erosion. Taken together with previous work (Anderson, Alden & Merski, Fd Chem. Toxic. 1982, 20, 105), these findings demonstrate that the ingestion of high doses of NTA results in similar effects on the transitional epithelium throughout the urinary tract.
mesh_terms: D000085:Acetates / Q000633:toxicity*; D000818:Animals; D004108:Dilatation, Pathologic / Q000139:chemically induced; D006869:Hydronephrosis / Q000139:chemically induced / Q000473:pathology; D007682:Kidney Pelvis / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009571:Nitrilotriacetic Acid / Q000633:toxicity*; D011859:Radiography; D051381:Rats; D011916:Rats, Inbred F344; D011919:Rats, Inbred Strains; D014513:Ureter / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology
chemical_list: D000085:Acetates; D009571:Nitrilotriacetic Acid