Desmosine and isodesmosine contents and elastase activity in normal and cirrhotic rat liver.
The contents of desmosine and isodesmosine, the cross-linking amino acids of elastin, were increased 4-fold in rat liver with carbon tetrachloride-induced cirrhosis, which suggests that insoluble elastin accumulates in cirrhosis. Elastase activity in the cirrhotic liver, as determined with 3-carboxypropionyl-L-alanyl-L-alanyl-L-alanine p-nitroanilide, was 17% less than in the normal liver; no change was found when Congo Red-elastin was used as a substrate.
D000596:Amino Acids / Q000032:analysis*; D000818:Animals; D003895:Desmosine / Q000032:analysis*; D005260:Female; D007524:Isodesmosine / Q000032:analysis*; D008099:Liver / Q000032:analysis* / Q000201:enzymology; D008106:Liver Cirrhosis, Experimental / Q000201:enzymology / Q000378:metabolism*; D010196:Pancreatic Elastase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013379:Substrate Specificity
D000596:Amino Acids; D003895:Desmosine; D007524:Isodesmosine; D010196:Pancreatic Elastase