Inhibition of bovine platelet function by T-2 toxin, HT-2 toxin, diacetoxyscirpenol and deoxynivalenol.
The aggregation of bovine platelets suspended in homologous plasma is inhibited in the presence of T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS) or deoxynivalenol (DON) when either collagen or ADP is used as the stimulatory agent for aggregation. For each of the mycotoxins the degree of inhibition is dependent on the amount of trichothecene present in the platelet suspension but is not dependent on the time of exposure of the platelets to the toxin. For both ADP- and collagen-stimulated platelets, the order of potency of inhibition is T-2 toxin greater than HT-2 toxin greater than DAS greater than DON. A significant (P less than 0.01) dose-dependent decrease was also observed in the amount of the thromboxane B2 released from collagen-stimulated platelets in the presence of each of the mycotoxins.
D000244:Adenosine Diphosphate / Q000037:antagonists & inhibitors; D000818:Animals; D002417:Cattle; D003094:Collagen / Q000037:antagonists & inhibitors; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D012717:Sesquiterpenes / Q000494:pharmacology*; D013605:T-2 Toxin / Q000494:pharmacology / Q000031:analogs & derivatives; D013929:Thromboxane B2 / Q000097:blood; D014255:Trichothecenes / Q000494:pharmacology*
D012717:Sesquiterpenes; D014255:Trichothecenes; D013929:Thromboxane B2; D000244:Adenosine Diphosphate; D003094:Collagen; D013605:T-2 Toxin; C007262:deoxynivalenol; C012351:HT-2 toxin; C001809:diacetoxyscirpenol