Specificity of the rat hepatocyte monosaccharide transporter.
The effect of a number of hexoses and pentoses on 3-O-methyl-D-glucose transport into isolated hepatocytes is reported. The hexoses tested inhibited transport in a competitive manner, with Ki values ranging from 80 to 190 mM. No significant inhibition was seen with either D-ribose or D-arabinose.
D019325:3-O-Methylglucose; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D006601:Hexoses / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008757:Methylglucosides / Q000378:metabolism; D009004:Monosaccharide Transport Proteins; D009005:Monosaccharides / Q000378:metabolism*; D010429:Pentoses / Q000494:pharmacology; D051381:Rats; D013329:Structure-Activity Relationship
D002352:Carrier Proteins; D006601:Hexoses; D008757:Methylglucosides; D009004:Monosaccharide Transport Proteins; D009005:Monosaccharides; D010429:Pentoses; D019325:3-O-Methylglucose