Neuromedin C: a bombesin-like peptide identified in porcine spinal cord.
From a side fraction obtained in our previous isolation of neuromedin B from porcine spinal cord, we have purified another decapeptide that exhibits a potent stimulant effect on the smooth muscle preparation of rat uterus. By microsequencing and synthesis, the amino acid sequence of the peptide has been identified as: Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2. This peptide is found to be identical with the carboxy-terminal subsequence [18-27] of gastrin releasing peptide, and to display a potent contractile activity on rat uterus in the characteristic manner of bombesin. These facts strongly suggest that the peptide may be a neuromediator in the neural communication systems of mammals. We propose the name "neuromedin C" for this peptide, since it is closely related to "neuromedin B", recently identified as a bombesin-like mammalian peptide.
D000595:Amino Acid Sequence; D000818:Animals; D001681:Biological Assay; D001839:Bombesin / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005260:Female; D019886:Gastrin-Releasing Peptide; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D009842:Oligopeptides / Q000302:isolation & purification / Q000494:pharmacology*; D010446:Peptide Fragments; D010455:Peptides; D051381:Rats; D013116:Spinal Cord / Q000032:analysis*; D013329:Structure-Activity Relationship; D013552:Swine; D014590:Uterine Contraction / Q000187:drug effects
D009842:Oligopeptides; D010446:Peptide Fragments; D010455:Peptides; D019886:Gastrin-Releasing Peptide; C040794:neuromedin C; D001839:Bombesin