title: Sequence of human adenosine deaminase cDNA including the coding region and a small intron.
abstract: The nucleotide sequence for an unusual, cloned human adenosine deaminase cDNA has been determined. Contained within a sequence of 1535 nucleotides is a coding sequence of 1089 nucleotides that encodes a protein of 40,762 daltons. The coding sequence is interrupted by a non-coding region containing 76 nucleotides. Both the 3' and 5' ends of this region have consensus sequences generally associated with splice sites. The 3' untranslated sequence contained 308 nucleotides, including a polyadenylation signal sequence 20 nucleotides from the end. The cloned cDNA appears to correspond to a nuclear mRNA precursor which contains a small intron.
mesh_terms: D000243:Adenosine Deaminase / Q000235:genetics*; D000595:Amino Acid Sequence; D001483:Base Sequence; D003001:Cloning, Molecular; D003062:Codon / Q000235:genetics; D004247:DNA / Q000302:isolation & purification*; D005796:Genes; D014644:Genetic Variation; D006801:Humans; D008970:Molecular Weight; D009700:Nucleoside Deaminases / Q000235:genetics*
chemical_list: D003062:Codon; D004247:DNA; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase