[Genetic aspects of the hormonal modification of stress reactivity. I. The prenatal effect of hydrocortisone on the reactivity of the hypophyseoadrenal system of adult August and Wistar strain rats and their 1st generation hybrids].
Influence of the alteration of corticosteroid equilibrium during prenatal development on the reactivity of the pituitary-adrenal system in adulthood was studied in August, Wistar rats and their F1 hybrids. The alteration of corticosteroid balance was caused by injections of hydrocortizone to female rats on the 16th and 18th day of gestation. Adult male-offsprings were investigated. The prenatal hydrocortizone treatment was capable of modifying the inherited peculiarities of the stress system. Interstrain differences in sensitivity to hormone were observed. Hormonal treatment decreased reactions of the endocrine system to an emotional stresser or intracerebral noradrenaline administration in Wistar rats, but not in August ones. Reciprocal hybrids were affected by the hormone, like Wistar rats. At the same time, treatment with hydrocortizone did not change the reactions of the pituitary-adrenal system of the rats of both strains under the conditions of "systemic" stress or intracerebral serotonin administration. Probably, hydrocortizone affected specific mechanisms of emotional reaction, connected with noradrenergic system of brain. Thus, the ability of prenatal hydrocortizone treatment to modify the reactivity of the pituitary-adrenal system in adult rats depends on the animal genotype. Sensitivity to the hormone is a dominant character.
D000305:Adrenal Cortex Hormones / Q000097:blood; D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000503:physiopathology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*; D013312:Stress, Physiological / Q000209:etiology / Q000235:genetics* / Q000503:physiopathology
D000305:Adrenal Cortex Hormones; D006854:Hydrocortisone
Geneticheskie aspekty gormonal'noĭ modifikatsii stressornoĭ reaktivnosti. Soobshchenie I. Prenatal'noe vliianie gidrokortizona na reaktivnost' gipofizarno-nadpochechnikovoĭ sistemy vzroslykh krys liniĭ Avgust i Vistar i ikh gibridov pervogo pokoleniia.