Mutagenicity of smoke condensate of bidi--an indigenous cigarette of India.
The possible mutagenicity of bidi smoke condensate (BSC), an indigenous form of an Indian cigarette has been studied using three short-term test systems. It was seen that BSC caused frame-shift mutations in Salmonella typhimurium strains TA 98 and TA 1538 and required metabolic activation. In the mammalian test systems, BSC induced 8 azaguanine resistant mutations in V79 Chinese hamster cells in the presence of S9 mixture and induced elevated frequencies of micronucleated erythrocytes in the bone marrow of Swiss mice.
D000818:Animals; D006224:Cricetinae; D003412:Cricetulus; D007194:India; D008297:Male; D051379:Mice; D009153:Mutagens; D010947:Plants, Toxic; D012906:Smoke / Q000009:adverse effects*; D014026:Nicotiana
D009153:Mutagens; D012906:Smoke