Hypervitaminosis A toxicity in regular hemodialysis patients.
A study has been made of possible inter-relationship between the plasma levels of vitamin A, retinol binding protein (RBP) prealbumin (PA), and biochemical parameters in 47 patients with end-stage renal failure maintained on regular dialysis treatment. The raised plasma concentrations of vitamin A, RBP and PA in patients were significantly different from those of normal controls. Plasma vitamin A levels were inversely correlated with Hct (r = -0.499), which was also significantly related to RBP/vitamin A ratio (r = 0.61). Plasma i-PTH and VLDL were inversely related to RBP/vitamin A and RBP/PA ratios. These findings suggest that raised plasma vitamin A levels in regular dialysis patients contribute to anemia and hypervitaminosis A toxicity. Vitamin A preparations should therefore not be given to patients on regular dialysis treatment.
D000328:Adult; D000368:Aged; D005260:Female; D006400:Hematocrit; D006801:Humans; D006986:Hypervitaminosis A; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011228:Prealbumin / Q000378:metabolism; D006435:Renal Dialysis; D012177:Retinol-Binding Proteins / Q000378:metabolism; D054839:Retinol-Binding Proteins, Plasma; D014801:Vitamin A / Q000097:blood
D011228:Prealbumin; D012177:Retinol-Binding Proteins; D054839:Retinol-Binding Proteins, Plasma; D014801:Vitamin A