[Effect of interferon and its liposome-incorporated inducer on the recovery of natural killer activity after immobilization stress].
In this work the data on the decrease of the activity of natural killer cells, determined in the test of the release of radioactive chromium from labeled target cells YAC-1 in CBA and BALB/c mice after stress caused by 6-hour immobilization, are presented. The use of mouse leukocyte interferon and the agents inducing its synthesis (double-helical RNA and poly I X poly C, especially poly I X poly C contained in liposomes) has been shown to be highly effective for the restoration of the activity of natural killer cells after its suppression at the period following the stress. The probable role of deficiency of interferon-inducing agents in the mechanisms of decrease of natural cell-mediated cytotoxicity after stress is discussed.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D006801:Humans; D007369:Interferon Inducers / Q000627:therapeutic use*; D007370:Interferon Type I / Q000627:therapeutic use*; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008081:Liposomes / Q000008:administration & dosage*; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D011070:Poly I-C / Q000627:therapeutic use; D012330:RNA, Double-Stranded / Q000627:therapeutic use; D012367:RNA, Viral / Q000627:therapeutic use; D012149:Restraint, Physical; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013315:Stress, Psychological / Q000276:immunology / Q000628:therapy*; D013997:Time Factors
D007369:Interferon Inducers; D007370:Interferon Type I; D008081:Liposomes; D012330:RNA, Double-Stranded; D012367:RNA, Viral; D011070:Poly I-C
Vliianie interferona i ego induktora, zakliuchennogo v liposomy, na vosstanovlenie aktivnosti estestvennykh killerov posle immobilizatsionnogo stressa.