title: Clinical, haematological and blood biochemical changes in goats after experimental infection with tick-borne fever.
abstract: Tick-borne fever in goats caused by Ehrlichia (Cytoecetes) phagocytophila was characterised by high fever, dullness, anorexia, tachycardia and a slight to moderate inhibition of rumen motility. The animals developed a gradual decline in the total number of circulating white blood cells. There was a decrease in lymphocytes over a short period, followed by an increase. The number of neutrophils was higher on the 3rd day, causing considerable change in the lymphocyte:neutrophil ratios. The number of eosinophils increased slightly. Serum alkaline phosphatase (ALP) decreased during the febrile episodes, and a marked decline was observed in both plasma zinc and iron concentrations. Furthermore, there was a small but progressive decrease of haemoglobin and haematocrit values. Circulating endogenous pyrogen/leucocyte endogenous mediator could not be detected in plasma from febrile goats. Tick-borne fever was passively transmitted to kids with plasma obtained from these febrile animals.
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001772:Blood Cell Count / Q000662:veterinary; D001831:Body Temperature; D004536:Ehrlichia; D005260:Female; D005769:Gastrointestinal Motility; D006041:Goats; D006339:Heart Rate; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D007501:Iron / Q000097:blood; D008297:Male; D012288:Rickettsiaceae Infections / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*
chemical_list: D006454:Hemoglobins; D007501:Iron; D000469:Alkaline Phosphatase