Studies of potential filaricides: Part 14--Activity of 1-iso-butoxycarbonyl-4-methylpiperazine against experimental filariasis.
The synthesis and filaricidal activity of 1-iso-butoxycarbonyl-4-methylpiperazine against Litomosoides carinii in Sigmodon hispidus and Dipetalonema viteae in Mastomys natalensis is reported. At an intraperitoneal or oral dose of 3 mg/kg given for 6 days, the compound removed 91% of the circulating microfilariae but had no effect on adult L. carinii. However, it killed all microfilariae and adults of D. viteae at a subcutaneous dose of 50 mg/kg given for 6 days. The compound also possessed chemoprophylactic activity against the larvae of L. carinii and D. viteae at a dose of 30 and 50 mg/kg respectively.
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D055598:Chemical Phenomena; D002621:Chemistry; D004154:Dipetalonema Infections / Q000188:drug therapy* / Q000469:parasitology; D005368:Filariasis / Q000188:drug therapy* / Q000469:parasitology; D005369:Filaricides / Q000138:chemical synthesis / Q000627:therapeutic use*; D008842:Microfilariae; D009115:Muridae; D010879:Piperazines / Q000138:chemical synthesis / Q000627:therapeutic use*
D000871:Anthelmintics; D005369:Filaricides; D010879:Piperazines; C043396:1-isobutoxycarbonyl-4-methylpiperazine