title: [Clinico-experimental and clinical studies of a ketomethine preparation in sheep and cows].
abstract: Some of the clinical parameters of the preparation ketomethyne, containing propylene glycol, methyonine, and Co bichloride, were comparatively studied with the analogous preparation ursoketin at oral application to sheep and cows. It was found that ketomethyne raised more slowly the level of blood sugar than ursoketin, but maintained it by 24-35 per cent higher than the initial level from the 6th to the 24th hour following treatment. The oral application of ketomethyne had no unfavourable effect on the rumen activity, the general clinical indices body temperature, pulse, respiration), the hematologic indices as hemoglobin and erythrocyte and leukocyte count, and the appetite. Similarly to ursoketin, ketomethyne was not readily taken by animals as judged by what was noted with ruminants in cases where the preparation was given as a supplement to the ordinary amounts of feed (concentrates). It was more successfully offered to the large ruminants when 5 to 8 kg silage and the preparation at the rate of 400-500 cm3 were admixed. With cows having paraclinical signs of ûetosis (hypoglycemia and ketonuria) the oral administration of ketomethyne at 500 cm3 in the course of four consecutive days produced favourable effects (up to 100 per cent). On such basis, therefore, the use of the preparation is worthwhile in the prevention of ketosis in sheep and cows or in their treatment.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy; D003035:Cobalt / Q000627:therapeutic use*; D004338:Drug Combinations; D004341:Drug Evaluation / Q000662:veterinary; D004353:Drug Evaluation, Preclinical / Q000662:veterinary; D007003:Hypoglycemia / Q000188:drug therapy / Q000662:veterinary; D007657:Ketone Bodies / Q000652:urine; D007662:Ketosis / Q000188:drug therapy / Q000662:veterinary; D008715:Methionine / Q000627:therapeutic use*; D011409:Propylene Glycols / Q000627:therapeutic use*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D004338:Drug Combinations; D007657:Ketone Bodies; D011409:Propylene Glycols; D003035:Cobalt; C043284:ketomethine; D008715:Methionine
vernacular_title: Kliniko-eksperimentalni i klinichni prouchvaniia na preparata ketometin pri ovtse i kravi.