Suppressive effect of ciramadol on the bradykinin-induced activities of the lamina V-type cells of the rat spinal dorsal horn.
The effects of a new analgesic drug, ciramadol, on single neuronal activities of lamina V-type cells of the spinal dorsal horn were investigated in spinal rats when applied microelectrophoretically to the cells or administered systemically. In the majority of lamina V-type cells examined, ciramadol inhibited the activities induced by intra-arterial injection of bradykinin (painful stimulation) but not those induced by mechanical noxious and innocuous stimuli. These results directly evidence that ciramadol acts on the lamina V-type cells of the spinal dorsal horn to block the bradykinin-induced (nociceptive) activities there.
D000588:Amines / Q000494:pharmacology*; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001596:Benzylamines / Q000494:pharmacology*; D001920:Bradykinin / Q000494:pharmacology*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000166:cytology*
D000588:Amines; D000700:Analgesics; D001596:Benzylamines; C018273:ciramadol; D001920:Bradykinin