DSIP-like material in brain parts of rats running a complex maze.
Delta sleep-inducing peptide-like immunoreactivity (DSIP-LI) was measured by radioimmunoassay (RIA) in individual brain areas of rats running a 12-choice maze. One of the areas found to contain a high level of DSIP-LI was the thalamus, where a distinct peak of immunoreactivity eluted at the position of the synthetic DSIP nonapeptide after high performance liquid chromatography (HPLC). On each of the two days of testing, DSIP-LI in the thalamus correlated significantly with running times in the maze. The results suggest an association of behavior with the levels of peptide in a region of the brain.
D000818:Animals; D001923:Brain Chemistry; D002540:Cerebral Cortex / Q000032:analysis; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D003701:Delta Sleep-Inducing Peptide; D007858:Learning / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000502:physiology; D009842:Oligopeptides / Q000032:analysis*; D011340:Problem Solving / Q000502:physiology*; D011863:Radioimmunoassay; D051381:Rats; D013788:Thalamus / Q000032:analysis
D009842:Oligopeptides; D003701:Delta Sleep-Inducing Peptide