[Comparative evaluation of the biogenic amine level of the brain and the ethanol kinetics in the blood of inbred C57B1/6 and CBA mice].
The kinetics of ethanol in blood and the levels of serotonin, noradrenaline, and dopamine in the cortex of cerebral hemispheres, hypothalamus, thalamus, and brain stem were studied in male C57C1/6 and CBA mice characterized by predisposition and non-predisposition to the development of experimental alcoholism. C57B1/6 mice characterized by predisposition to the development of experimental alcoholism demonstrated a high level of serotonin and noradrenaline in the hypothalamus and brain stem and high rate of ethanol elimination from the blood. CBA mice non-predisposed to the development of experimental alcoholism were characterized by a low level of serotonin and noradrenaline in the hypothalamus and brain stem and by low rate of ethanol elimination from blood.
D000437:Alcoholism / Q000378:metabolism; D000818:Animals; D001679:Biogenic Amines / Q000032:analysis / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D004198:Disease Susceptibility; D000431:Ethanol / Q000097:blood*; D006801:Humans; D007700:Kinetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000378:metabolism*; D008808:Mice, Inbred CBA / Q000378:metabolism*
D001679:Biogenic Amines; D000431:Ethanol
Sravnitel'naia otsenka urovnia biogennykh aminov golovnogo mozga i kinetiki étanola v krovi mysheĭ inbrednykh liniĭ C57B1/6 i CBA.