Simulated responses to intermittent lognormally distributed doses at variable dose rates.
Two previously reported equations for low-LET radiation, R = DmI-n and R = D[a + b(lnI) + h(lnI)2], where the response (R) is expressed in terms of dose (D) and dose rate (I) and the other parameters are constants, were used to compute distributions of response to intermittent, low-level, lognormally distributed doses, administered at different dose rates. The simulations show that the means of the response distributions are affected by both the dose and dose rate distributions. Within certain ranges of their respective values, the influence of the dose and dose rate on the response are in opposite directions, and lead to similar response distributions for numerically different combinations of dose and dose rate. The resolution and mean values of response distributions, when based on nonlinear dose-response relationships, are also affected by dose fractionation.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D008567:Membranes, Artificial; D051379:Mice; D008954:Models, Biological; D009154:Mutation; D010743:Phospholipids / Q000528:radiation effects; D011831:Radiation Genetics; D012984:Software
D008567:Membranes, Artificial; D010743:Phospholipids