[Conjugated dinitrocompound dianions as inhibitors of the oxidative deamination of monoamines].
The conjugated derivatives--1.4-dinitrobutene-2, 1,4-dinitro-2-methylbutene-2, 1,4-dinitro-2,3-diphenylbutene-2 sodium salts, as well as dinitromethane sodium salt and beta-nitrostyrol, the inhibitors of oxidative deamination of serotonin, tyramine, tryptamine and benzylamine in bovine liver mitochondria, were studied. All the derivatives under study were found to be active inhibitors of monoamine oxidase catalyzing the oxidative deamination of serotonin, tyramine and tryptamine. In a far lesser degree these preparations inhibited the deamination of benzylamine, a specific substrate for monoamine oxidase B. All the dinitrocompound dianions, with the exception of 1,4-dinitro-2,3-diphenylbutene-2 disodium salt, a non-competitive inhibitor of oxidative deamination of the four substrates under study, cause competitive reversible inhibition of monoamine oxidase.
D000475:Alkenes / Q000494:pharmacology; D000588:Amines / Q000378:metabolism*; D000818:Animals; D001596:Benzylamines / Q000378:metabolism*; D002417:Cattle; D003641:Deamination; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009574:Nitro Compounds / Q000494:pharmacology; D010084:Oxidation-Reduction; D012701:Serotonin / Q000378:metabolism*; D013379:Substrate Specificity; D014363:Tryptamines / Q000378:metabolism*; D014439:Tyramine / Q000378:metabolism*
D000475:Alkenes; D000588:Amines; D001596:Benzylamines; D008996:Monoamine Oxidase Inhibitors; D009574:Nitro Compounds; D014363:Tryptamines; C044329:1,4-dinitro-2-methyl-2-butene; D012701:Serotonin; C030820:tryptamine; C044328:1,4-dinitro-2-butene; C044330:1,4-dinitro-2,3-diphenyl-2-butene; C030796:benzylamine; D008995:Monoamine Oxidase; D014439:Tyramine
Sopriazhennye dianiony dinitrosoedineniĭ v kachestve ingibitorov okislitel'nogo dezaminirvaniia monoaminov.