title: The synthesis of [1,2,3,4-13C] cortisol.
abstract: The preparation of [1,2,3,4-13C] cortisol 21 acetate by total synthesis is described. The C labels are introduced in a way analogous to the one described by us previously for the synthesis of testosterone and estradiol. The cortisol dihydroxyacetone side chain was elaborated using known methods. The 11 beta-hydroxyl function was introduced by addition of hypobromous acid to a 9-double bond followed by reductive debromination. 13C-labeled cortisol can be used as a tracer for the determination of cortisol production rates.
mesh_terms: D002247:Carbon Isotopes; D055598:Chemical Phenomena; D002621:Chemistry; D006854:Hydrocortisone / Q000138:chemical synthesis*; D013058:Mass Spectrometry
chemical_list: D002247:Carbon Isotopes; D006854:Hydrocortisone