title: [Hydrolysis of the antiemetic alizapride].
abstract: First order rate constants of the hydrolysis of N-[(1-allyl-2-pyrrolidinyl)-methyl]-6-methoxy-1H-benzotriazole-5-carboxa mide (alizapride, Vergentan) in acid and alkaline medium were determined. The activation energy observed in alkaline solution was 60.3 kJ X mol-1. The substance was not hydrolized in vitro by esterase, liver homogenate and plasma.
mesh_terms: D000818:Animals; D000932:Antiemetics / Q000032:analysis* / Q000378:metabolism; D004950:Esterases / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D011759:Pyrrolidines / Q000032:analysis* / Q000378:metabolism; D051381:Rats
chemical_list: D000932:Antiemetics; D011759:Pyrrolidines; D004950:Esterases; C033968:alizapride
vernacular_title: Hydrolyse des Antiemetikums Alizaprid.