title: [Synthesis and neurologic action of new 11-substituted 5H-dibenzo[b,e][1,4]diazepines].
abstract: The synthesis of the title compounds is described. The compounds are characterized by having no cataleptogenic effect and no antagonistic effect against amphetamine stereotypies in experimental animals. The pharmacological results of the rota-rod, spontaneous motility, aggression-test, hexobarbital-potentiation and antagonism to physostigmine are reported.
mesh_terms: D000374:Aggression / Q000187:drug effects; D000661:Amphetamine / Q000037:antagonists & inhibitors; D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003024:Clozapine / Q000494:pharmacology; D003984:Dibenzazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D006591:Hexobarbital / Q000494:pharmacology; D006719:Homovanillic Acid / Q000378:metabolism; D006801:Humans; D007928:Lethal Dose 50; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010830:Physostigmine / Q000037:antagonists & inhibitors; D011619:Psychotropic Drugs / Q000138:chemical synthesis*; D051381:Rats; D012890:Sleep / Q000187:drug effects
chemical_list: D000700:Analgesics; D003984:Dibenzazepines; D011619:Psychotropic Drugs; D010830:Physostigmine; D006591:Hexobarbital; D000661:Amphetamine; D003024:Clozapine; D006719:Homovanillic Acid
vernacular_title: Synthese und neurologische Wirkung neuer 11-substituierter 5H-Dibenzo[b,e][1,4]diazepine.