Phencyclidine-induced catalepsy in pigeons: specificity and stereoselectivity.
A procedure is described for the rapid assessment of cataleptic activity (loss of righting, without head-drop and without eye closure) of phencyclidine-type drugs. Single- and cumulative-dosing procedures with phencyclidine and ketamine produced similar results. Pentobarbital produced loss of righting at doses which also induced head-drop and eye closure. Catalepsy was induced exclusively by the d-isomers of ketamine, 1-(1-phenylcyclohexyl)-3-methylpiperidine and alpha-dioxadrol. The procedure is suitable for studying compounds which may interact with phencyclidine receptors.
D000818:Animals; D002375:Catalepsy / Q000139:chemically induced*; D010856:Columbidae; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007649:Ketamine / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology; D010622:Phencyclidine / Q000031:analogs & derivatives / Q000494:pharmacology*; D013237:Stereoisomerism
C036590:1-(1-phenylcyclohexyl)-3-methylpiperidine; D007649:Ketamine; D010424:Pentobarbital; D010622:Phencyclidine