title: [Oestrogens in the cell: differences between uterine and mammary tissue].
abstract: The studies reported here on the distribution of oestrogens in different cellular compartments in the uterine and mammary tissue, which was determined by means of a new extraction method, show great differences in concentration of oestradiol and oestrone in the cellular nucleus and in the cytosol. These data are very difficult to reconcile with the conventional model of the mechanism of action of the oestrogens in the cell. The results would rather indicate that the chemically detectable receptors are not freely available without exception to all steroids in the cytosol of the cell.
mesh_terms: D001940:Breast / Q000032:analysis*; D001943:Breast Neoplasms / Q000032:analysis; D002467:Cell Nucleus / Q000032:analysis; D003600:Cytosol / Q000032:analysis; D004717:Endometrium / Q000032:analysis; D004958:Estradiol / Q000032:analysis; D004967:Estrogens / Q000032:analysis*; D004970:Estrone / Q000032:analysis; D005260:Female; D006801:Humans; D014599:Uterus / Q000032:analysis*
chemical_list: D004967:Estrogens; D004970:Estrone; D004958:Estradiol
vernacular_title: Ostrogene in der Zelle: Unterschiede zwischen Uterus- und Brustgewebe.