title: [Incidence of neoplasms in non-congenital refractory anemias. Ferrokinetic pattern].
abstract: Twenty cases of refractory anemia were studied by means of ferrokinetic analysis with Fe-59. An accelerated plasma clearing, a diminished iron uptake by red cells, and a decreased bone marrow activity were found. Half of the cases showed secondary liver and spleen hemochromatosis. The incidence of malignant tumors observed in the studied refractory anemias was 35% (7 out of 20 cases, corresponding to 4 solid tumors and 3 leukemias). The authors suggest the convenience to study erythropoiesis in anemias with an obscure origin using the ferrokinetic procedure with Fe-59.
mesh_terms: D000328:Adult; D000368:Aged; D000753:Anemia, Refractory / Q000150:complications* / Q000378:metabolism; D001853:Bone Marrow / Q000378:metabolism; D004920:Erythropoiesis; D005260:Female; D006432:Hemochromatosis / Q000209:etiology; D006801:Humans; D007501:Iron / Q000378:metabolism*; D007700:Kinetics; D007938:Leukemia / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000209:etiology*
chemical_list: D007501:Iron
vernacular_title: Incidencia de neoplasias en anemias refractarias no congénitas. Patrón ferrocinético.