title: Activity of novel aminocannabinoids in baboons.
abstract: The axial and equatorial isomers of 7-(methylamino)hexahydrocannabinol (1 and 2) and 7-(dimethylamino)hexahydrocannabinol (3 and 4) were prepared by reductive amination of the corresponding cannabinoid aldehydes. The amines caused some tranquility in baboons but did not evoke the typical cannabimimetic syndrome caused by psychoactive cannabinoids. However the axial amines (1 and 3) but not the equatorial ones (2 and 4) caused bouts of scratching and yawning. The latter is a rare pharmacological effect hitherto not observed with other cannabinoids.
mesh_terms: D000818:Animals; D002186:Cannabinoids / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008968:Molecular Conformation; D009904:Optical Rotation; D010215:Papio; D013055:Spectrophotometry, Infrared; D013239:Stereotyped Behavior / Q000187:drug effects*; D013329:Structure-Activity Relationship
chemical_list: D002186:Cannabinoids