Disturbances in collagen synthesis in trisomic cells from spontaneously aborted embryos.
Collagen synthesis in cells with trisomy 7 and 9 derived from human spontaneous abortuses was found to be lower (5.06% and 5.53% respectively) than in the control diploid cells (8.80%). The ratio of collagen types (I/III) in trisomic strains did not differ from the control data while the amount of the degraded procollagen in trisomic cells was increased.
D000022:Abortion, Spontaneous; D002478:Cells, Cultured; D002906:Chromosomes, Human, 6-12 and X; D003094:Collagen / Q000096:biosynthesis* / Q000235:genetics; D004622:Embryo, Mammalian / Q000378:metabolism; D005109:Extracellular Matrix / Q000378:metabolism; D005260:Female; D005347:Fibroblasts; D006801:Humans; D008297:Male; D011247:Pregnancy; D014314:Trisomy
D003094:Collagen