title: Effect of prostaglandin E1 on bile flow in the rat.
abstract: The effect of intravenous administration of prostaglandin E1 on bile flow in the rat was investigated. PGE1 infused at concentrations of 4.5, 7.5 and 15 micrograms/kg body weight/min caused an initial increase in bile acid-independent bile flow rate which peaked within 30 min and was followed by a significant decrease (p less than 0.01) below the control value. However, PGE1 administered intravenously at an infusion rate of 15 micrograms X kg-1 X min-1 showed a significant decrease (p less than 0.01) in bile acid-dependent bile flow rate.
mesh_terms: D000527:Alprostadil; D000818:Animals; D001646:Bile / Q000187:drug effects*; D001647:Bile Acids and Salts / Q000378:metabolism; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D001647:Bile Acids and Salts; D011458:Prostaglandins E; D000527:Alprostadil