title: Choroidal microvascular repair after argon laser photocoagulation. Ultrastructural observations.
abstract: Acute laser injury to the tapetum of the feline retina produces thrombosis of the choriocapillaris. Early changes are characterized by the appearance of platelet-fibrin thrombi within capillary loops and disruption of endothelial integrity. By 4 days, thrombi have disappeared, and the endothelium shows regenerative changes. No endothelial cell mitotic activity is seen. The endothelial cytoplasm becomes plump, and there is a loss of the fenestrations adjacent to Bruch's membrane. By 10-20 days, the capillary structure shows gradual restoration. At 30 days, endothelial cell fenestrae are clearly evident adjacent to Bruch's membrane. The reparative process in this model appears to evolve as a result of thrombolysis and endothelial cell activation.
mesh_terms: D000818:Animals; D002415:Cats; D002829:Choroid / Q000098:blood supply / Q000293:injuries* / Q000503:physiopathology / Q000648:ultrastructure; D053685:Laser Therapy; D007834:Lasers / Q000009:adverse effects*; D012038:Regeneration; D012160:Retina / Q000648:ultrastructure*; D012164:Retinal Diseases / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D012171:Retinal Vessels / Q000503:physiopathology / Q000648:ultrastructure*; D014603:Uveal Diseases / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology