[Gastrointestinal disturbance by cancer chemotherapy--recent progress in antiemetic regimens].
Antiemetic procedure is now an indispensable supportive care for cisplatin-based combination chemotherapy. During the past several years, many efforts have been done to establish the effective antiemetic regimen for cisplatin-induced emesis. We report here that effective protection of cisplatin-induced emesis by the combination of moderate dose of steroid and domperidone. Taking account of reports by others, we can conclude that multiple combination of antiemetic drugs including steroid, over 200 mg of hydrocortisone, seems to be the most effective procedure to protect emesis induced cisplatin. The second problem of gastrointestinal disturbance induced chemotherapy in anorexia lasting several days. As for this problem little is known at present.
D000328:Adult; D000368:Aged; D000818:Animals; D000932:Antiemetics / Q000145:classification; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage*; D004294:Domperidone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000188:drug therapy; D008297:Male; D008787:Metoclopramide / Q000008:administration & dosage*; D008875:Middle Aged; D009325:Nausea / Q000517:prevention & control*; D009369:Neoplasms / Q000188:drug therapy*
D000932:Antiemetics; D004294:Domperidone; D008787:Metoclopramide; D002945:Cisplatin; D006854:Hydrocortisone