[Potential fibrinolytic activity of the blood in jaundice of parenchymal and mechanical origin].
The activity of plasminogen (Pl) and proactivator of plasminogen (PPl) was studied in 812 patients, 682 of them sick with liver diseases and 130 healthy. A total of 419 patients with various clinical forms of viral hepatitis were covered: 35 patients with acute liver insufficiency, 39--with decompensated cirrhosis of liver, 16--cholangiohepatitis, 16--toxic hepatitis and 157 patients with mechanical jaundice. Coagulation micromethods were applied. The referentive values were derived: f for Pl--83-126%; for PPl--80-120%. The activity of Pl and PPl in jaundice with parenchymal nature was established to be, most frequently, reduced and correlated well with the severity and the phase of the morbid process--the lowest enzyme activity was established in acute liver insufficiency, decompensated liver cirrhosis and severe forms of vital hepatitis, at the earlier phases. Enzyme activity in mechanical jaundice is, most often, normal and rarely enhanced. The fibrinolytic enzymes obtained could help the differential diagnosis of jaundice and are of significance in the determination of the severity of the parenchymal liver diseases.
D002779:Cholestasis / Q000175:diagnosis / Q000209:etiology / Q000503:physiopathology*; D003937:Diagnosis, Differential; D005342:Fibrinolysis; D006525:Hepatitis, Viral, Human / Q000150:complications / Q000503:physiopathology; D006801:Humans; D008107:Liver Diseases / Q000150:complications / Q000503:physiopathology; D010958:Plasminogen / Q000032:analysis; D010960:Plasminogen Activators / Q000097:blood
D010958:Plasminogen; D010960:Plasminogen Activators
Prouchvaniia vŭrkhu potentsialnata fibrinolitichna aktivnost na krŭvta pri zhŭltenitsi ot parenkhimno i mekhanichno estestvo.