Temporal changes in chromosome abnormality rate in human spontaneous abortions: evidence for an association between sex-chromosome monosomy and trisomy 16.
As part of a cytogenetic survey of human spontaneous abortions, the relative frequencies of different categories of chromosome abnormalities were evaluated for possible temporal changes. Three classes of chromosome abnormalities showed significant linear trends; sex-chromosome monosomy and tetraploidy decreased over the study period, while trisomy increased. The increase in trisomy was largely attributable to trisomy 16, which showed a two-fold increase over the duration of the study. The linear increase in trisomy 16 was inversely related to sex-chromosome monosomy. This effect was restricted to women over 30 yr of age and was most pronounced among Oriental women.
D000022:Abortion, Spontaneous / Q000235:genetics / Q000473:pathology*; D000328:Adult; D002869:Chromosome Aberrations / Q000453:epidemiology / Q000473:pathology*; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D002902:Chromosomes, Human, 16-18 / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D009006:Monosomy; D011123:Polyploidy; D011247:Pregnancy; D044469:Racial Groups; D012729:Sex Chromosome Aberrations / Q000453:epidemiology / Q000473:pathology; D013997:Time Factors; D014314:Trisomy; D014960:X Chromosome / Q000648:ultrastructure*; D014998:Y Chromosome / Q000648:ultrastructure*