[Ultrastructural and biochemical evidence of brain damage by the serum IgG fraction of the blood of schizophrenics].
Using electron microscopic and biochemical studies, the rat brain was examined following the intracisternal administration of IgG obtained from schizophrenics' blood serum. The resultant ultrastructural impairments of the sensorimotor cortex and activation of lipid peroxidation processes were similar to the alterations detected in the brain of the schizophrenic patients. The results suggest that the circulating cerebral antibodies in schizophrenics possess a membranotropic effect and may induce various structural and functional disorders in the central nervous system of these patients.
D000818:Animals; D001323:Autoantibodies; D001921:Brain / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D007074:Immunoglobulin G; D007278:Injections, Spinal; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008297:Male; D008854:Microscopy, Electron; D009044:Motor Cortex / Q000648:ultrastructure; D051381:Rats; D012559:Schizophrenia / Q000276:immunology*; D013003:Somatosensory Cortex / Q000648:ultrastructure
D001323:Autoantibodies; D007074:Immunoglobulin G; D008054:Lipid Peroxides
Ul'trastrukturnye i biokhimicheskie dokazatel'stva povrezhdeniia mozga fraktsieĭ IgG iz syvorotki krovi bol'nykh shizofrenieĭ.