title: Induction of a 'stress' protein in intact mammalian organs after the intravenous administration of sodium arsenite.
abstract: The profile of nascent proteins synthesized in various rabbit organs after the intravenous injection of sodium arsenite was analyzed by the cell-free translation of purified polysomes. Examination of the translation products of polysomes isolated 1 hr after injection of sodium arsenite revealed a marked induction of synthesis of a protein of molecular weight 74,000 (74K) in the kidney, heart and liver which was similar to a 'heat shock' protein which was induced in these organs after elevation of body temperature by 2.5 to 3 degrees C. Synthesis of the 74K protein was not detected in the translation products of brain polysomes isolated 1 hr after sodium arsenite injection.
mesh_terms: D000818:Animals; D001151:Arsenic / Q000494:pharmacology*; D018053:Arsenites; D001923:Brain Chemistry; D002474:Cell-Free System; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D009928:Organ Specificity; D011132:Polyribosomes / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000187:drug effects; D011817:Rabbits; D017670:Sodium Compounds
chemical_list: D018053:Arsenites; D006360:Heat-Shock Proteins; D017670:Sodium Compounds; C017947:sodium arsenite; D001151:Arsenic