title: Resistance to Haemonchus contortus transferred between genetically histocompatible sheep by immune lymphocytes.
abstract: The pattern of faecal egg counts after infection with 10,000 Haemonchus contortus larvae was similar within but not between, four pairs of monozygous twin sheep. Transfer of whole lymph or washed lymph cells from three immune donor sheep to their identical co-twin recipients reduced the susceptibility of the recipients to challenge with 10,000 larvae as measured by faecal egg counts. Cells from a nonimmune donor did not have this effect. In a final experiment, washed cells from an immune triplet sheep, which was actively responding to a repeated challenge infection, transferred a secondary local IgA response to a second recipient triplet and resulted in a marked reduction in worm count when compared with that of a third infectivity control triplet.
mesh_terms: D000818:Animals; D005243:Feces / Q000469:parasitology; D005260:Female; D006188:Haemonchiasis / Q000276:immunology / Q000662:veterinary*; D006648:Histocompatibility; D006801:Humans; D007116:Immunization, Passive / Q000662:veterinary*; D007070:Immunoglobulin A / Q000096:biosynthesis; D008098:Litter Size; D008196:Lymph / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D010270:Parasite Egg Count / Q000662:veterinary; D011247:Pregnancy; D012756:Sheep / Q000235:genetics; D012757:Sheep Diseases / Q000276:immunology*; D014252:Trichostrongyloidiasis / Q000662:veterinary*; D014430:Twins, Monozygotic
chemical_list: D007070:Immunoglobulin A