[Test of the efficacy of low-molecular tetanus antitoxin].
Experiments on rabbits, white rats and mice with experimental tetanus intoxication were made to study and compare the efficacy of the tetanus antitoxin Diaferm-3 and its Fab'-fragments. Fab'-fragments were discovered to be more effective in the early stages of intoxication, when injected in fairly high doses and partially when administered intracarotidally. Intracisternal injection of the antitoxin Diaferm-3 appeared the most effective for the treatment of demonstrable intoxication.
D000818:Animals; D007140:Immunoglobulin Fab Fragments / Q000276:immunology; D007128:Immunoglobulin Fragments / Q000276:immunology; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D007278:Injections, Spinal; D051379:Mice; D011817:Rabbits; D051381:Rats; D013742:Tetanus / Q000188:drug therapy*; D013743:Tetanus Antitoxin / Q000008:administration & dosage / Q000627:therapeutic use*
D007140:Immunoglobulin Fab Fragments; D007128:Immunoglobulin Fragments; D013743:Tetanus Antitoxin
Ispytanie éffektivnosti nizkomolekuliarnogo stolbniachnogo antitoksina.