title: Filaricidal effects of cyclosporin-A against Dipetalonema viteae in Mastomys natalensis.
abstract: Outbred male Mastomys natalensis were injected subcutaneously with 100 infective larvae of Dipetalonema viteae obtained from Ornithodorus tartakovskyi. Groups of five animals were treated with 30 mg/kg of the immunosuppressive drug Cyclosporin-A daily for five days (experimental) or Miglyol 812 (control). One group served as untreated controls. Contrary to expectations, 60% of the animals were completely protected against D. viteae and the remainder were partially protected. The mechanism remains unknown.
mesh_terms: D000818:Animals; D001769:Blood / Q000469:parasitology; D003524:Cyclosporins / Q000627:therapeutic use*; D004153:Dipetalonema / Q000302:isolation & purification; D004154:Dipetalonema Infections / Q000188:drug therapy* / Q000469:parasitology; D005368:Filariasis / Q000188:drug therapy*; D008297:Male; D008842:Microfilariae / Q000302:isolation & purification; D009115:Muridae
chemical_list: D003524:Cyclosporins