title: Antimuscarinic compounds and gastric kinetics: a study with pirenzepine on healthy subjects.
abstract: A study has been made on the modifications that appear after acute dosage of pirenzepine in a series of eight healthy subjects of both sexes who had shown, by radioisotopic evaluation, a physiological pattern of gastric kinetics. The acute dosage of the drug was continued for three days at therapeutic doses and, a few hours after the last administration, the same study was repeated. As a test meal, a whole fried egg containing 99mTc-labelled serum albumin was used. The kinetics of the gastric content was scanned by a gamma-camera. The difference in gastric kinetics between the baseline situation and that after administration of the drug is reported and discussed.
mesh_terms: D000328:Adult; D001570:Benzodiazepinones / Q000378:metabolism*; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D005753:Gastric Mucosa / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D010276:Parasympatholytics / Q000378:metabolism*; D010890:Pirenzepine
chemical_list: D001570:Benzodiazepinones; D010276:Parasympatholytics; D010890:Pirenzepine