Treatment with vitamin D or its analogues does not change body weight or blood glucose level in postmenopausal women.
It has recently been stated that vitamin D analogues can reduce body weight in animal models. We evaluated the effect of treatment with vitamin D metabolites on the nutritional status of 238 postmenopausal women, who were participating in three double-blind placebo-controlled trials, the aim of which was to prevent or treat postmenopausal bone loss. After two years of treatment with vitamin D3, 2000 IU daily (n = 25), or l alpha OHD3, 0.25 micrograms daily (n = 23), or 1 year of treatment with 1,25 (OH)2D3, 0.25-0.50 micrograms daily (n = 40), no change in body weight or blood glucose level could be detected when compared to corresponding placebo treated groups (n = 150). It is concluded that the effect of vitamin D analogues on body weight is a phenomenon which is specific for an animal model and does not occur in man.
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism*; D001835:Body Weight / Q000187:drug effects*; D002117:Calcitriol / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D008593:Menopause; D008875:Middle Aged; D014807:Vitamin D / Q000494:pharmacology*
D001786:Blood Glucose; D006887:Hydroxycholecalciferols; D014807:Vitamin D; D002117:Calcitriol; D002118:Calcium; C008088:alfacalcidol