The effects of intrahypothalamic hemicholinium-3 on muricide, irritability and feeding.
Male Long-Evans rats that consistently killed mice when food deprived were injected unilaterally in the lateral hypothalamus with 20 micrograms and 30 micrograms of the acetylcholine synthesis inhibitor hemicholinium-3 (HC-3) and saline in a counterbalanced order. Rats were evaluated 1, 2, 3, 24, 48 and 72 hours post-injection for effects on muricide, irritability and feeding. HC-3 suppressed muricide and feeding and produced a trend toward reduced irritability during the first three hours post-injection. These data indicate that modulation of cholinergic systems in the lateral hypothalamus influences several behaviors and not any one behavior specifically.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D005247:Feeding Behavior / Q000187:drug effects*; D006234:Handling, Psychological; D006426:Hemicholinium 3 / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007031:Hypothalamus / Q000473:pathology / Q000502:physiology*; D007267:Injections; D007837:Latency Period, Psychological; D008297:Male; D051379:Mice; D051381:Rats
D006426:Hemicholinium 3