Magnesium and potassium deprivation and supplementation in animals and man: aspects in view of intestinal absorption.
States of K and Mg deficiency, deprivation or depletion, are difficult to detect by determining serum concentrations, since both cations are concentrated intracellularly. The intestinal absorption of K is rather quick and complete; the uptake of Mg probably comprises two mechanisms and proceeds continuously, although incomplete. The resulting different pharmakokinetic behavior must be kept in mind when K and Mg are supplemented by the oral route. Favorable effects of oral K and Mg supplementation are reviewed, and the fact is stressed that the body cannot retain K, unless the Mg status is adequate. Therefore, K should be supplemented together with Mg. Drugs like amiloride not only spare K, but at the same time prevent renal losses of other important electrolytes, especially of chloride and Mg.
D000284:Administration, Oral; D000818:Animals; D004032:Diet; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007408:Intestinal Absorption; D008274:Magnesium / Q000008:administration & dosage / Q000378:metabolism; D008275:Magnesium Deficiency / Q000378:metabolism*; D011188:Potassium / Q000008:administration & dosage / Q000378:metabolism; D011191:Potassium Deficiency / Q000378:metabolism*; D051381:Rats; D011918:Rats, Inbred SHR
D008274:Magnesium; D011188:Potassium