Effect of topically applied forskolin on aqueous humor dynamics in cynomolgus monkey.
Topical administration of a 1% forskolin suspension significantly reduced intraocular pressure in cynomolgus monkey eyes. The fall in intraocular pressure was associated with a significant (P less than 0.01) decrease in aqueous humor flow measured by a fluorophotometric technique. No significant change was found in tonographic outflow facility or pupillary diameter. A loss of effect on intraocular pressure to subsequent doses of 1% forskolin suspension occurred in cynomolgus monkeys by the third day of twice-a-day treatment.
D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects* / Q000502:physiology; D005576:Colforsin; D004224:Diterpenes / Q000008:administration & dosage / Q000494:pharmacology*; D005470:Fluorometry / Q000379:methods; D007429:Intraocular Pressure / Q000187:drug effects*; D008252:Macaca fascicularis; D013997:Time Factors
D004224:Diterpenes; D005576:Colforsin