The effect of combination treatment with cis-platinum and low dose rate 125I radiation in a murine brachytherapy model.
We studied the effect of combination treatment with cis-platinum during low dose rate irradiation from 125I sources in the RIF-1 murine flank tumor model. Cell survival measured with a colony forming efficiency assay was used as the experimental endpoint. Sources implanted into tumors delivered 25 Gy of radiation to isodosed annuli of tissue at a dose rate of 1.3 Gy/hr. When 3 mg/kg of cis-platinum was administered 24, 12, and 1 hr before or 0, 12 and 24 hr after irradiation, the effect on cell kill was additive. Thus in the RIF-1 model there is no particular advantage gained by treatment with the combinations of cis-platinum and 125I radiation used in these studies.
D000818:Animals; D001918:Brachytherapy; D002945:Cisplatin / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*
D007457:Iodine Radioisotopes; D002945:Cisplatin