Purification and sequence of an opioid peptide derived from ovine proenkephalin.
An enkephalin-containing peptide originating from ovine adrenal proenkephalin has been purified and sequenced. The sequence of the peptide is: GLY-GLY-GLU-VAL-LEU-GLY-LYS-ARG-TYR-GLY-GLY-PHE-MET (preproenkephalin 128-140) which represents a portion of peptide F (preproenkephalin 107-140). This peptide has a sequence identical to that of bovine preproenkephalin 128-140 while it differs from the corresponding human sequence in positions 129, 131 and 133.
D000302:Adrenal Cortex / Q000032:analysis*; D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D002837:Chromaffin Granules / Q000032:analysis*; D002838:Chromaffin System / Q000032:analysis*; D004745:Enkephalins / Q000302:isolation & purification*; D006801:Humans; D011498:Protein Precursors / Q000302:isolation & purification*; D012756:Sheep; D013045:Species Specificity
D004745:Enkephalins; D011498:Protein Precursors; C029992:proenkephalin; C033660:preproenkephalin