Hypervitaminosis A: a contributing factor to anemia in regular dialysis patients.
In order to evaluate the toxicity of hypervitaminosis A in regular dialysis patients, the relationships between the plasma levels of vitamin A, retinol binding protein (RBP), prealbumin (PA), and biochemical parameters were studied in 47 patients. Plasma vitamin A levels were inversely correlated with hematocrit (r = -0.5), which was also significantly correlated with RBP/vitamin A ratio (r = 0.61). Immunoreactive parathyroid hormone (i-PTH) and very low density lipoprotein (VLDL) were inversely related to RBP/vitamin A and RBP/PA ratios. These findings suggest that a raised plasma vitamin A level in regular dialysis patients contributes to anemia and hypervitaminosis A toxicity.
D000328:Adult; D000368:Aged; D000740:Anemia / Q000209:etiology*; D006400:Hematocrit; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy; D008079:Lipoproteins, VLDL / Q000097:blood; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D011228:Prealbumin / Q000378:metabolism; D006435:Renal Dialysis; D012177:Retinol-Binding Proteins / Q000378:metabolism; D054839:Retinol-Binding Proteins, Plasma; D014801:Vitamin A / Q000097:blood*
D008079:Lipoproteins, VLDL; D010281:Parathyroid Hormone; D011228:Prealbumin; D012177:Retinol-Binding Proteins; D054839:Retinol-Binding Proteins, Plasma; D014801:Vitamin A