Demonstration of a neuropeptide Y-like immunoreactivity in human phaeochromocytoma extracts.
Using a porcine neuropeptide Y directed radioimmunoassay it was shown that acid extracts of human phaeochromocytoma tumour tissue contained a neuropeptide Y-like peptide. Further fractionation and purification of this immunoreactivity showed that this human neuropeptide Y-like immunoreactivity was closely similar in molecular size and separation characteristics to porcine neuropeptide Y. The possible contribution of neuropeptide Y to the hypertension characterizing human phaeochromocytoma is discussed.
D002850:Chromatography, Gel; D003429:Cross Reactions; D006801:Humans; D009419:Nerve Tissue Proteins / Q000276:immunology / Q000302:isolation & purification*; D009478:Neuropeptide Y; D010191:Pancreatic Polypeptide / Q000276:immunology; D019894:Peptide YY; D010455:Peptides / Q000276:immunology; D010673:Pheochromocytoma / Q000032:analysis*; D011863:Radioimmunoassay; D014661:Vasoconstriction
D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D010455:Peptides; D019894:Peptide YY; C009725:pancreatic polypeptide, avian; D010191:Pancreatic Polypeptide