Biological activity of glycosides of vitamin D3 and 1 alpha-hydroxyvitamin D3.
For the first time, the biological activity of the newly synthesized glycosides of vitamin D3 and of 1 alpha(OH)D3 has been studied in rats, chickens, and Japanese quails. Glucosidation did not reduce the activity of vitamin D3. In chickens, vitamin D3 glucoside has an activity of 90% to 95% as compared to the aglycon. In rats vitamin D3 glucoside is equally active when given by intravenous or oral route. Glycosides of 1 alpha (OH)D3, however, show a lower activity in rats, chickens, and quails. 1 alpha (OH)D3 glucoside has about 10% activity of the free 1 alpha (OH)D3, while 1 alpha (OH)D3 cellobioside is without any activity in chickens. 1 alpha (OH)D3 glucoside might be of interest, due to its broader therapeutical dosage range.
D000284:Administration, Oral; D000818:Animals; D001681:Biological Assay; D002113:Calcification, Physiologic / Q000187:drug effects*; D002645:Chickens; D003370:Coturnix; D006887:Hydroxycholecalciferols / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D010710:Phosphates / Q000097:blood; D051381:Rats; D012279:Rickets / Q000378:metabolism; D014807:Vitamin D / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
D006887:Hydroxycholecalciferols; D010710:Phosphates; D014807:Vitamin D; C042202:vitamin D3 3 beta-D-glucopyranoside; C042200:1-hydroxyvitamin D3-cellobioside; C042201:1-hydroxyvitamin D3 3-D-glucopyranoside