Influence of dietary sodium on the natriuretic activity of atrial tissue.
Natriuretic activity of atrial myocardial extracts was determined by bioassay in rats. An extract from rats fed low Na chow for 3 weeks contained significantly greater (P less than 0.01) natriuretic activity than extracts from controls. Extracts from rats fed low Na chow for 1 week or from rats fed normal chow with saline to drink for 1 or 3 weeks did not have significantly different natriuretic activities compared to controls. However, the atrial natriuretic activity of the 3-week saline group was significantly greater (p less than 0.05) than the 1-week saline group. These results indicate that changes in dietary sodium intake are associated with changes in atrial natriuretic activity. However, the precise role of atrial natriuretic factor in sodium homeostasis remains to be elucidated.
D000818:Animals; D001681:Biological Assay; D001794:Blood Pressure / Q000187:drug effects; D004039:Diet, Sodium-Restricted; D005260:Female; D006325:Heart Atria / Q000378:metabolism*; D008297:Male; D009318:Natriuresis; D045283:Natriuretic Agents; D011506:Proteins / Q000032:analysis* / Q000302:isolation & purification; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism / Q000494:pharmacology*; D014563:Urodynamics / Q000187:drug effects
D045283:Natriuretic Agents; D011506:Proteins; D012964:Sodium