Activity of cephalosporins against methicillin-resistant coagulase-negative staphylococci.
Using a dilution method (37 degrees C, 42 h), six of ten methicillin-resistant strains of coagulase-negative staphylococci were found to be resistant to cephalothin. Of 20 variations in the method for detection of resistance to methicillin and cephalothin, broth dilution tests at 30 degrees C for 42 h were the most sensitive. Differences are explained by low percentages of cephalothin-resistant clones in methicillin-resistant strains.
D002511:Cephalosporins / Q000494:pharmacology*; D003030:Coagulase / Q000032:analysis*; D008712:Methicillin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D013210:Staphylococcus / Q000187:drug effects* / Q000201:enzymology
D002511:Cephalosporins; D003030:Coagulase; D008712:Methicillin