title: Serum levels of aluminium and magnesium in animals and man after administration of high doses of almagate.
abstract: Repeated administration of almagate (hydrated aluminium-magnesium hydroxycarbonate, Al2Mg6(OH)14(CO3)2 X 4 H2O, Almax) in doses up to 4 g/kg to rats for 30 days did not result in increased serum levels of magnesium. After single doses of 4 g/kg of almagate, aluminium could not be detected at the limit of detection (0.025 ppm). A slight but physiologically not significant increase in the concentrations of both of these ions was observed after administration of 0.27 g/kg to dogs but not after 0.135 g/kg. The absorption of aluminium and magnesium in volunteers treated for 5 days with almagate and two other non-systemic antacids was compared. There was no increment in the serum levels of magnesium above the basal level or of aluminium above the lowest detectable level. Almagate may therefore be classified as a non-systemic antacid.
mesh_terms: D000328:Adult; D000535:Aluminum / Q000097:blood*; D000536:Aluminum Hydroxide / Q000008:administration & dosage*; D000818:Animals; D000863:Antacids / Q000008:administration & dosage*; D002254:Carbonates / Q000008:administration & dosage*; D004285:Dogs; D005260:Female; D006801:Humans; D008274:Magnesium / Q000008:administration & dosage* / Q000097:blood*; D008276:Magnesium Hydroxide / Q000008:administration & dosage*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
chemical_list: D000863:Antacids; D002254:Carbonates; C043698:almagate; D000536:Aluminum Hydroxide; D000535:Aluminum; D008274:Magnesium; D008276:Magnesium Hydroxide