title: Topical problems in the study of remote effects of chemical compounds on the cardiovascular system.
abstract: The main tasks in epidemiological and experimental study of remote effects on the cardiovascular system of exposure to chemical compounds were formulated. In the epidemiological respect, the most important points are development of methods for integral evaluation of the effect of the environment, including the industrial environment, and improvement of the methods of detecting early signs of cardiovascular pathology closely correlating with the structure of cardiovascular morbidity and mortality. The most topical experimental problem is to refine the criteria and methods of assessing the state of the heart and vessels of experimental animals so as to make possible a substantiated and adequate extrapolation of experimental data to man.
mesh_terms: D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects* / Q000473:pathology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D064420:Drug-Related Side Effects and Adverse Reactions; D006801:Humans; D012107:Research Design; D012306:Risk