Norepinephrine-like effects of neuropeptide Y on LH release in the rat.
Neuropeptide Y, a recently isolated neuropeptide exhibited norepinephrine-like effects on LH release after intracerebroventricular administration at doses from 0.5 to 10 micrograms. While it promptly suppressed LH release in ovariectomized rats, there was a dose-related stimulation of LH secretion in ovarian steroid primed-ovariectomized rats. In view of the evidence that neuropeptide Y may coexist with adrenergic neurotransmitters, these findings suggest that it may play a role in regulation of LH release in the rat, either independently or in concert with catecholamines.
D000818:Animals; D002369:Castration; D004305:Dose-Response Relationship, Drug; D005260:Female; D007986:Luteinizing Hormone / Q000097:blood*; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D009478:Neuropeptide Y; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D007986:Luteinizing Hormone; D009638:Norepinephrine