Treatment of pulmonary acariasis in rhesus macaques with ivermectin.
Rhesus monkeys were treated for pulmonary acariasis with single injections of ivermectin (200 micrograms/kg). Monkeys were killed and complete necropsies performed. Control monkeys had numerous live mites, while treated monkeys had only dead, frequently fragmented mites. Histopathologically, inflammatory lesions were most severe in control monkeys and monkeys killed one week after treatment. Inflammatory changes progressively decreased with increasing time post treatment.
D000818:Animals; D005260:Female; D007306:Insecticides / Q000627:therapeutic use*; D007559:Ivermectin; D007783:Lactones / Q000627:therapeutic use*; D008168:Lung / Q000473:pathology; D008174:Lung Diseases, Parasitic / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008251:Macaca; D008253:Macaca mulatta; D008297:Male; D008924:Mite Infestations / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D008992:Monkey Diseases / Q000188:drug therapy* / Q000473:pathology
D007306:Insecticides; D007783:Lactones; D007559:Ivermectin