title: Ultrastructural study of enriched fractions of "tangles" from human patients with senile dementia of the Alzheimer type.
abstract: Enriched fractions of "tangles" obtained from cases of Alzheimer's disease have been observed by negative staining and platinum: iridium shadowing, and also after treatment with sodium dodecyl sulfate and urea. Abnormal filaments with a 80-nm periodic constriction exhibited a substructure consisting of six protofilaments. They also showed a periodic right-handed twist. Some fibrils with a 160-nm periodic constriction were made up of four protofilaments. These features are discussed in view of known fibrous protein models, especially neurofilaments.
mesh_terms: D000368:Aged; D055598:Chemical Phenomena; D002621:Chemistry; D003599:Cytoskeleton / Q000648:ultrastructure; D003704:Dementia / Q000473:pathology*; D006801:Humans; D008854:Microscopy, Electron; D008956:Models, Chemical; D009454:Neurofibrils / Q000648:ultrastructure*