Immunostimulating hexapeptide from human casein: amino acid sequence, synthesis and biological properties.
A hexapeptide obtained from human casein by enzymatic digestion has been purified, sequenced and synthesized; its structure is: Val-Glu-Pro-Ile-Pro-Tyr. In vitro this hexapeptide stimulates the phagocytosis of opsonized sheep red blood cells by murine peritoneal macrophages. Administered intravenously to adult mice, it enhances the resistance to infection with Klebsiella pneumoniae.
D000276:Adjuvants, Immunologic / Q000138:chemical synthesis / Q000302:isolation & purification*; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006801:Humans; D007710:Klebsiella Infections / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009842:Oligopeptides / Q000138:chemical synthesis / Q000302:isolation & purification* / Q000494:pharmacology; D010587:Phagocytosis / Q000187:drug effects; D012756:Sheep / Q000276:immunology
D000276:Adjuvants, Immunologic; D000596:Amino Acids; D009842:Oligopeptides; C043891:valyl-glutamyl-prolyl-isoleucyl-prolyl-tyrosine