Influence of sulfur-containing compounds on the acute toxicity of cyclophosphamide in male Sprague-Dawley rats.
The acute toxicity of cyclophosphamide (CP) was investigated following the pretreatment with seven sulfur-containing compounds (SCC): disulfiram (DSF), diethyldithiocarbamate (DDTC), L-cysteine (Cys), N-acetyl-L-cysteine (Ac-Cys), S-carboxymethyl-L-cysteine (Carb-Cys), D-penicillamine (Pen), and cysteamine hydrochloride (1-amino-3-mercaptoethane X HCl, C-NH). The following LD50 values were recorded: CP alone 254, CP + DSF 77, CP + DDTC 260, CP + Cys 345, CP + Ac-Cys 319, CP + Carb-Cys 271, CP + Pen 392, CP + C-NH 299 mg/kg b.wt. Only DSF significantly increased the toxicity of cyclophosphamide. None of the SCC tested seems to be superior to mesna (sodium 2-mercaptoethane sulfonate), a selective protector against cyclophosphamide-induced bladder and kidney toxicity.
D000818:Animals; D003520:Cyclophosphamide / Q000633:toxicity*; D004347:Drug Interactions; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013455:Sulfur / Q000494:pharmacology*
D013455:Sulfur; D003520:Cyclophosphamide