Plasma levels of opioid analgesics determined by radioreceptor assay.
Plasma levels of opioid drugs, Mr 1268 MS (3-(2-methyl-3-furylmethyl)-1,2,3,4,5,6-hexahydro-6 alpha,11 alpha-dimetyl-2,6-methano-3-benzazocin-8-ol methane sulfonate), Mr 2033 CL ( [2 alpha, 3(S*), 6 alpha, 11 R*]-(+/-)-1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-[(tetrahydro-2-furanyl) methyl]-2,6-methano-3-benzazocin-8-ol hydrochloride), MRZ 2549 BR ( (2-methoxypropyl)-1,2,3,4,5,6-hexahydro-6 alpha, 11 alpha-dimethyl-2,6-methano-3-benzazocin-8-ol hydrobromide), and pentazocine, have been determined by a radioreceptor assay after enteral and parenteral administration to human volunteers as well as to laboratory animals (monkeys and dogs), using [3H]dihydromorphine as radioligand and freshly prepared membrane homogenates of rat brains. The concentration of parent compound drug has been evaluated after a specific extraction from plasma. The method described presents a universal possibility for the determination of opioid drugs of different structures in plasma and other body fluids.
D000700:Analgesics / Q000097:blood*; D000818:Animals; D001575:Benzomorphans / Q000031:analogs & derivatives / Q000097:blood; D001921:Brain / Q000378:metabolism; D004285:Dogs; D006207:Half-Life; D006801:Humans; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D007700:Kinetics; D008253:Macaca mulatta; D008297:Male; D008566:Membranes / Q000378:metabolism; D009294:Narcotics / Q000097:blood*; D010423:Pentazocine / Q000097:blood; D011489:Protein Denaturation; D011869:Radioligand Assay / Q000379:methods; D051381:Rats; D011919:Rats, Inbred Strains
D000700:Analgesics; D001575:Benzomorphans; D009294:Narcotics; C032478:MR 2034; C033491:Mr 1268; C032479:MRZ 2549; D010423:Pentazocine