Induction of tumours of the urinary bladder in F344 rats by dietary administration of o-phenylphenol.
o-Phenylphenol (OPP), a fungicide approved as a food additive in Japan, was given in pelleted diets at dietary levels of 0.156, 0.313, 0.625, 1.25 or 2.5% to groups of 11 or 12 F344/DuCrj rats of each sex for 13 wk, and 0.625, 1.25 or 2.5% to groups of 20-24 male F344/DuCrj rats for 91 wk. In the 13-wk study, transitional cell papillomas of the urinary bladder occurred in 6/12 (50%) of the male 1.25% group. In the 91-wk study, urinary bladder tumours appeared in 23/24 (96%) of the 1.25% and 4/23 (17%) of the 2.5% group. Among these tumours, transitional cell carcinomas were found in 20/23 (87%) of 1.25% and 2/4 (50%) of the 2.5% groups. A dose-related increase in the incidence of nephritic lesions was also observed in dosed rats in both the 13- and 91-wk study.
D000284:Administration, Oral; D000818:Animals; D001713:Biphenyl Compounds / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D009374:Neoplasms, Experimental / Q000473:pathology; D051381:Rats; D011916:Rats, Inbred F344; D001745:Urinary Bladder Diseases / Q000139:chemically induced / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000473:pathology
D001713:Biphenyl Compounds; C004369:2-phenylphenol