Effect of some selected anti-inflammatory steroids on elastin content in liver of rats treated with carbon tetrachloride.
Hepatic fibrosis was induced in rats by poisoning them with carbon tetrachloride. The influence of anti-inflammatory steroids (hydrocortisone, prednisone, dexamathasone) upon elastin content in liver was investigated in healthy and CCl4 intoxicated rats. An increase of liver elastin content was observed in animals with CCl4-induced hepatic fibrosis Opposite results were obtained in normal rats after treating them with glucocorticosteroids. A decrease of elastin content after steroid treatment was also found in rats with injured liver, as compared to animals receiving CCl4 only. Presumable mechanisms of the results are discussed.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D002252:Carbon Tetrachloride Poisoning / Q000378:metabolism*; D004549:Elastin / Q000032:analysis*; D005938:Glucocorticoids / Q000494:pharmacology*; D008099:Liver / Q000032:analysis / Q000187:drug effects*; D008103:Liver Cirrhosis / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D004549:Elastin