Interaction between chlorpromazine and intrathecally injected non-ionic contrast media in non-anaesthetized rabbits.
During a 14-day period, 45 of 78 rabbits were treated intravenously with chlorpromazine (5 mg kg-1 day-1). Metrizamide or iohexol was injected subarachnoidally and the neurotoxic effects of each substance on rabbit behaviour were evaluated for 3 h in both chlorpromazine-treated and non-treated rabbits. Chlorpromazine increased both the excitative and the depressive effects of metrizamide and the depressive effects of iohexol. No signs of excitation were observed in chlorpromazine-treated and non-treated rabbits after subarachnoid injections of iohexol. In spite of a free flow of clear fluid from the needle both before and after the intended subarachnoid injection, radiography disclosed that 26 of 67 suboccipital injections inadvertently resulted in a subdural deposition of the contrast medium. Contrast medium effects following subdural injection significantly differed from those following subarachnoid injection.
D017109:Akathisia, Drug-Induced; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007278:Injections, Spinal; D007463:Iodobenzoates / Q000494:pharmacology*; D007472:Iohexol; D008297:Male; D008793:Metrizamide / Q000008:administration & dosage / Q000494:pharmacology*; D009420:Nervous System / Q000187:drug effects*; D011817:Rabbits; D013355:Subdural Space; D013997:Time Factors; D014283:Triiodobenzoic Acids / Q000008:administration & dosage / Q000494:pharmacology*
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D007472:Iohexol; D008793:Metrizamide; D002746:Chlorpromazine