title: Hyper IgE syndrome: four case report.
abstract: Patients with hyper IgE syndrome (HIES) have varying degree of immunological unbalance that account for deficiency of total T and OKT8 lymphocytes. To investigate the role of immunostimulating drugs in HIES, thymostimulin (TP1) and levamisole were given in highly controlled groups of patients after a wash out period with disodium-chromoglycate (DSCG). Both drugs do not modify clinical picture whereas they do modulate some laboratory parameters as T lymphocyte total number, IgE plasmatic concentration, neutrophil chemotaxis. Furthermore TP1 had a worsening clinical effect in 3 of our patients. In our opinion we feel that the therapies proposed and employed so far for this rare disease must be critically analyzed.
mesh_terms: D000911:Antibodies, Monoclonal / Q000032:analysis; D002634:Chemotaxis, Leukocyte; D002648:Child; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology / Q000628:therapy*; D007073:Immunoglobulin E / Q000032:analysis*; D007167:Immunotherapy; D007958:Leukocyte Count; D007978:Levamisole / Q000627:therapeutic use; D013949:Thymus Extracts / Q000627:therapeutic use
chemical_list: D000911:Antibodies, Monoclonal; D013949:Thymus Extracts; C031407:thymostimulin; D007978:Levamisole; D007073:Immunoglobulin E