Ascorbic acid in thyroidectomized rats. II) Ascorbic acid status of the storage tissues and hepatic biosynthesis of glucuronic acid.
Depletion of ascorbic acid from adrenals, brain and epididymis along with loss in weight were noticed in the state of thyroidectomy. This decrease appears to be due to an effect of thyroidectomy on the membrane integrity since the membrane bound sialic acid was found to be significantly lowered in these tissues as a consequence of the elevated activity of sialidase. Thyroidectomy was also found to cause an adverse effect on the activities of hepatic UDP-glucuronyl transferase and beta-glucuronidase with no alteration in UDP-glucose dehydrogenase.
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D004822:Epididymis / Q000378:metabolism; D005965:Glucuronates / Q000096:biosynthesis*; D020723:Glucuronic Acid; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D012794:Sialic Acids / Q000378:metabolism; D013961:Thyroid Gland / Q000502:physiology*; D013965:Thyroidectomy
D005965:Glucuronates; D012794:Sialic Acids; D020723:Glucuronic Acid; D001205:Ascorbic Acid