Effect of combination chemotherapy on murine bladder cancer.
A murine bladder tumor model was evaluated for tumor growth retardation while receiving combination chemotherapy, either 40 mg/m2 methotrexate and 35 mg/m2 cis-platinum or 500 mg/m2 cytoxan and 35 mg/m2 cis-platinum at 3-week intervals. Tumor growth was observed in the control and treated groups. A significant decrease (p less than 0.001) in tumor growth and lung metastasis was noted in the cytoxan and cis-platinum group. Although the 40 mg/m2 group treated with methotrexate and 35 mg/m2 cis-platinum showed a decrease in tumor growth, it was not significant (p greater than 0.1), and lung metastasis was greater than in the control group. Cis-platinum with cytoxan was clearly effective in retarding tumor growth and metastatic spread.
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D002945:Cisplatin / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D004334:Drug Administration Schedule; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D051379:Mice; D008815:Mice, Inbred Strains; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*
D003520:Cyclophosphamide; D002945:Cisplatin; D008727:Methotrexate