Behavioral effects of piracetam in rats with isolation syndrome.
Piracetam in doses of 300 and 600 mg/kg i.p. administered for 5 days in Wistar rats with isolation syndrome produced a transient inhibition of mouse-killing behavior. Its anti-aggressive effect was most pronounced on days 2 and 3 of drug administration. On day 5 all aggressive rats again exhibited mouse-killing behavior. Piracetam in both doses was less effective in avoidance learning of aggressive rats. These results suggest that piracetam has a slight effect on the aggressive behavior of rats with isolation syndrome. No relationship exists between the antiaggressive and the learning-facilitating effects of piracetam.
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D006801:Humans; D008297:Male; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012934:Social Isolation; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D011760:Pyrrolidinones; D005680:gamma-Aminobutyric Acid; D010889:Piracetam