Effects of peptide YY and neuropeptide Y on gastric emptying in man.
Neuropeptide Y (NPY) and peptide YY (PYY) are two structurally related peptides. PYY has been identified within endocrine cells and NPY within nerves of the gastrointestinal tract. Infusion of PYY at a low dose at a nominal rate of 2 pmol/kg/min resulted in an increment of 59.2 +/- 7.1 pmol/1 in plasma concentration and a significant delay in gastric emptying of glucose. Infusion of NPY at the same rate produced similar plasma concentrations (52.5 +/- 1.1 pmol/1) and had no significant effect on the rate of gastric emptying.
D000293:Adolescent; D000328:Adult; D003102:Colloids; D005746:Gastric Emptying / Q000187:drug effects*; D005768:Gastrointestinal Hormones / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009419:Nerve Tissue Proteins / Q000097:blood / Q000494:pharmacology*; D009478:Neuropeptide Y; D019894:Peptide YY; D010455:Peptides / Q000097:blood / Q000494:pharmacology*; D013667:Technetium; D017556:Technetium Compounds; D014001:Tin; D017971:Tin Compounds
D003102:Colloids; D005768:Gastrointestinal Hormones; D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D010455:Peptides; D017556:Technetium Compounds; D017971:Tin Compounds; C033493:technetium Tc 99m tin colloid; D019894:Peptide YY; D013667:Technetium; D014001:Tin