title: Vestibulo-ocular reflexes in peripheral labyrinthine lesions: I. Unilateral dysfunction.
abstract: Measurements were made of the lesion-induced changes in vestibulo-ocular reflexes to rotatory stimuli in a group of patients with total unilateral labyrinthine paralysis and in a group with partial unilateral labyrinthine paralysis. Significant differences were found in the amplitude and phase of the response to low-frequency rotation and in the time constant of the post-rotatory response to impulsive rotation between normal subjects and patients with total unilateral labyrinthine paralysis. The results were evaluated by the use of a simplified model of vestibular function that allows the parametric evaluation of the characteristics of vestibular responses. It was found that changes in vestibulo-ocular reflex characteristics take place in parallel in both the time constant and the sensitivity of the system parameters used to describe the responses. The physiologic significance of the changes and their implication for diagnostic purposes are discussed.
mesh_terms: D004585:Electrooculography; D005583:Fourier Analysis; D006801:Humans; D007759:Labyrinth Diseases / Q000503:physiopathology*; D010243:Paralysis / Q000503:physiopathology; D011930:Reaction Time / Q000502:physiology; D012018:Reflex / Q000502:physiology; D012984:Software; D014724:Vestibular Function Tests