title: Development of the lymph nodes in the very young, and their evolution in the mature, nude rat.
abstract: We recently revised the concepts on the morphology of the lymph nodes of the young adult athymic nude rat. The present work studied the postnatal development of its nodal structures and their evolution with aging. The structural development of the deep cortex "units" was found to progress as usual. However, while the concentration of lymphocytes appeared to develop normally in the periphery of a unit, the center of the unit remained lymphocyte-depleted. Further, the peripheral cortex failed to develop over the middle part of a unit center. With aging, the peripheral cortex over the remainder of a unit center could atrophy and disappear completely. The present findings did not yield information as to whether thymic elements are necessary to trigger the development of a unit, but they revealed that its further development is determined by stimuli. It was concluded that, in the absence of T-cells, stimuli for cellular immune responses provoke the proliferation of the reticular or interdigitating cells of a unit center. On the other hand, an increase of these stimuli was concluded to cause the peripheral cortex to fail to develop over part of a unit center and, later, to atrophy over the remainder of the unit center. The mechanisms of the phenomena are discussed.
mesh_terms: D000375:Aging; D000818:Animals; D008198:Lymph Nodes / Q000033:anatomy & histology / Q000254:growth & development*; D008214:Lymphocytes / Q000166:cytology; D008407:Mast Cells / Q000166:cytology; D051379:Mice; D008819:Mice, Nude / Q000254:growth & development*; D051381:Rats