Studies on new antifungal antibiotics, guanidylfungins A and B. II. Structure elucidation and biosynthesis.
The structures of guanidylfungins A and B were elucidated from the physico-chemical properties of these compounds and the structures of the degradation products by ozonolysis and periodate oxidation. The guanidylfungins consist of a 36-membered polyhydroxyl lactone ring, a guanidine and a monoester of malonic acid. The labelling experiments with sodium [1-13C]acetate and sodium [1-13C]propionate revealed that twelve units of acetate and nine of propionate were incorporated into the molecule of guanidylfungin A.
D000935:Antifungal Agents / Q000096:biosynthesis; D055598:Chemical Phenomena; D002621:Chemistry; D007783:Lactones / Q000096:biosynthesis; D009682:Magnetic Resonance Spectroscopy; D013302:Streptomyces / Q000378:metabolism*
D000935:Antifungal Agents; D007783:Lactones; C043675:guanidylfungin B; C043674:guanidylfungin A