The stress of intruding: reduction by chlordiazepoxide.
Rats placed as intruders in a long-established colony showed significant elevations of plasma corticosterone after 10-20 minutes of intruding. This rise was prevented by 5 days pretreatment with chlordiazepoxide (5 mg/kg). The rats resident in the colony had significantly higher basal corticosterone concentrations compared with singly housed rats but the same as rats housed in groups of six in a normal cage. The resident rats showed no elevation of plasma corticosterone in response to 20 minutes of an intruder in the colony.
D000374:Aggression / Q000187:drug effects*; D000378:Agonistic Behavior / Q000187:drug effects*; D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology* / Q000627:therapeutic use; D003345:Corticosterone / Q000097:blood*; D004195:Disease Models, Animal; D051381:Rats; D013315:Stress, Psychological / Q000097:blood / Q000188:drug therapy
D002707:Chlordiazepoxide; D003345:Corticosterone