title: Group I pepsinogens in serum. I. Normal range, age and sex relation, diurnal rhythm, seasonal variation, and distribution in ABO blood groups.
abstract: The concentration of group I pepsinogens (PG I) in serum was determined in 235 healthy persons and hospital controls. The concentration was significantly higher in males. Correction of PG I with regard to body weight or lean body mass eliminated the sex difference but not the weak correlation with age. The normal range was 0.60-3.3 ng PG I/ml serum/kg body weight. For comparison with other PG I studies another normal range, 46-211 ng PG I/ml serum, was calculated as the 95% interpercentile range of the present PG I concentrations. In a study of diurnal rhythm and in a 6-month study of seasonal variation, no significant variation of PG I in serum was found. Serious non-gastric surgical disease did not influence the PG I level in serum. The PG I levels in blood groups O, A, and B did not differ significantly.
mesh_terms: D000017:ABO Blood-Group System; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D020116:Pepsinogen A; D010435:Pepsinogens / Q000097:blood*; D010446:Peptide Fragments / Q000097:blood*; D012016:Reference Values; D012621:Seasons; D012737:Sex Factors
chemical_list: D000017:ABO Blood-Group System; D010435:Pepsinogens; D010446:Peptide Fragments; C037980:pepsinogen (1-12); D020116:Pepsinogen A