title: Results obtained in short-term experiments and their application prospects in prognosticating threshold levels of chronic exposure to chemical compounds.
abstract: Joint studies carried out by toxicologists of CMEA countries have led to the development of new ways of approach to the problem of rapid establishment of toxicometric parameters and hygienic standards (TSEL, MAC) for the working-zone atmosphere. One of the most promising approaches is the rapid establishment of MAC from the threshold of acute specific effect. Upon this principle, methodical directives for determining MAC values for specifically active irritants were elaborated. A study of the quantitative relations between toxicometric parameters and the physicochemical properties of substances in the working-zone atmosphere furnished methods for calculating TSEL values for noxious substances in this atmosphere. The essential possibility was confirmed of using isolated mitochondria as a model for preliminarily estimating the toxicity and establishing safe concentration levels of noxious substances in the working-zone atmosphere. The application of a complex of functional, biochemical and morphometric indices made it possible to foretell from short-term experiments minimal effective concentrations of a substance on chronic exposure. Ways of further research in the field of prognosticating toxicometric parameters and hygienic regulations for chemical compounds are outlined.
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology; D011379:Prognosis; D012107:Research Design; D014050:Toluene / Q000633:toxicity; D014116:Toxicology
chemical_list: D014050:Toluene