Myoglobin release in patients with angina pectoris following short-term ischaemia by pacing to angina.
Thirteen patients with severe stable angina pectoris were studied by coronary sinus catheterization. In all patients, severe chest pains were produced by atrial pacing. The chest pains had disappeared within 10 min after pacing. Simultaneous arterial (a) and coronary sinus (cs) blood samples were taken before, during and after pacing and analyzed for myoglobin and lactate. The a-cs difference of myoglobin tended to become more negative after pacing, although the change was not significant. However, the change in negative direction post-pacing of the a-cs myoglobin difference was quantitatively correlated with the change in negative direction of the a-cs lactate difference during pacing in the individual patients. This suggests that short-term myocardial ischaemia without signs of established myocardial infarction may provoke myocardial myoglobin release.
D000208:Acute Disease; D000787:Angina Pectoris / Q000097:blood* / Q000150:complications; D002304:Cardiac Pacing, Artificial; D003327:Coronary Disease / Q000209:etiology / Q000378:metabolism*; D006339:Heart Rate; D006801:Humans; D007773:Lactates / Q000097:blood; D008875:Middle Aged; D009211:Myoglobin / Q000097:blood*
D007773:Lactates; D009211:Myoglobin