Effects of analogs of (pyro)Glu-His-Gly-OH on food consumption and gastric acid secretion in rats.
The effects of administration of (pyro)Glu-His-Gly-OH and its analogs on food consumption and 2-Deoxy-D-Glucose (2-DG)-induced gastric acid secretion were examined in rats. (Pyro)Glu-His-Gly-OH and (pyro)Glu-His-EA significantly reduced food consumption, but not gastric acid secretion as compared with controls. The tripeptides: (pyro)Glu-3Me-His-Gly-OH, (pyro)Glu-His-D-Ala-OH, and (pyro)Glu-Phe-Gly-OH were found to significantly inhibit 2-DG-induced gastric acid secretion. Our results indicate that some analogs of (pyro)Glu-His-Gly-OH cause a greater inhibition of food consumption or gastric acid secretion in rats than the original tripeptide, in analogy to findings obtained in dogs.
D000818:Animals; D003847:Deoxyglucose / Q000494:pharmacology; D004151:Dipeptides / Q000494:pharmacology; D004435:Eating / Q000187:drug effects*; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D011919:Rats, Inbred Strains
D004151:Dipeptides; D009842:Oligopeptides; C041870:pyroglutamylhistidyl-N-ethylamide; C023866:pyroglutamyl-histidyl-glycine; C041872:pyroglutamyl-3-methylhistidyl-glycine; C041871:pyroglutamyl-histidyl-alanine; C041873:pyroglutamyl-phenylalanyl-glycine; D003847:Deoxyglucose; D011761:Pyrrolidonecarboxylic Acid