Augmentation of antitumor resistance by a strain of unicellular green algae, Chlorella vulgaris.
Growth of Meth-A tumor in CDF1 mice was inhibited significantly by injection of a hot water extract of a strain of Chlorella vulgaris (CE) into the tumor or into the subcutaneous tissue near the tumor. The augmentation of resistance by CE may require the participation of T cells and macrophages, since it was abolished or reduced in athymic nude mice or mice treated with carrageenan, a macrophage blocker. Mice treated with CE exhibited antigen-specific augmented resistance against rechallenge with tumor. Moreover, the antitumor effect of CE was comparable with that of Corynebacterium parvum, but its mechanism of effect might be different.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002351:Carrageenan / Q000494:pharmacology; D002471:Cell Transformation, Neoplastic / Q000187:drug effects / Q000473:pathology; D002708:Chlorella / Q000276:immunology*; D005260:Female; D005354:Fibrosarcoma / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D007113:Immunity, Innate / Q000187:drug effects; D008198:Lymph Nodes / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011425:Propionibacterium acnes / Q000276:immunology
D000276:Adjuvants, Immunologic; D002351:Carrageenan