The role of congeners in the effects of different alcoholic beverages.
Five different alcoholic beverages were tested in rats to determine if congener content contributed to the hypothermia or motor impairment produced by the beverages. Solutions of cognac, scotch, tequila, vodka, and commercially supplied ethanol were diluted with physiological saline to form solutions containing 16% w/v ethanol, as verified by gas chromatographic analysis. All beverages were administered in doses containing 0 (saline), 1.6, 3.2, 4.8, or 6.4 g/kg ethanol (gastric intubation) in test sessions separated by 7 days (repeated measures design, N = 8 rats per group). Measurements of rectal temperature and motor impairment (rotarod performance) made at 0, 60, and 120 minutes postinjection revealed no noteworthy differences in either measure at 60 or 120 minutes postinjection at any of the 4 doses tested. Thus, no evidence for a contribution of congeners to beverage effects was observed.
D000434:Alcoholic Beverages / Q000009:adverse effects*; D000435:Alcoholic Intoxication / Q000097:blood*; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000097:blood*; D005260:Female; D006801:Humans; D008657:Metabolic Clearance Rate / Q000187:drug effects; D009048:Motor Skills / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000431:Ethanol