New hexahydro[1,4]diazepine-7H-5,7-diones with potential neurotropic activity.
Fourteen new derivatives of hexahydro[1,4]diazepine-7H-5,7-dione were synthesized and tested for neurotropic activity. Some of them showed strong analgesic activity in the hot plate test.
D000700:Analgesics / Q000138:chemical synthesis* / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D001381:Azepines / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D006380:Helplessness, Learned; D006591:Hexobarbital / Q000494:pharmacology; D006801:Humans; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D012890:Sleep / Q000187:drug effects
D000700:Analgesics; D000927:Anticonvulsants; D001381:Azepines; D006591:Hexobarbital