Report on subacute toxicological studies with dichloromethane in rats and dogs by inhalation.
The 90-day inhalation studies, conducted in 1975, showed that for dichloromethane the highest concentration without side effects can be expected just below 5,000 ppm by volume of air (0.5% by vol.) when administered to Beagle dogs. With rats the lowest toxic concentration was just below 10,000 ppm by volume (local tolerance) or above 10,000 ppm by volume (systemic tolerance). Administration took place on 90 consecutive days for 6 h per day.
D000818:Animals; D004285:Dogs; D004562:Electrocardiography; D004798:Enzymes / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D008752:Methylene Chloride / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D004798:Enzymes; D006843:Hydrocarbons, Chlorinated; D008752:Methylene Chloride