Vitamin D conversion by sarcoid lymph node homogenate.
Recent studies suggest that hypercalcemia of sarcoidosis is due to high blood concentrations of calcitriol and that this compound may be synthesized at an extra-renal site. We report that sarcoid lymph node homogenate metabolized calcifediol to a substance indistinguishable from calcitriol, whereas six nonsarcoid lymph nodes failed to produce this compound.
D002112:Calcifediol / Q000378:metabolism; D002117:Calcitriol / Q000378:metabolism; D004100:Dihydroxycholecalciferols / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008198:Lymph Nodes / Q000378:metabolism*; D008206:Lymphatic Diseases / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012507:Sarcoidosis / Q000378:metabolism*; D014807:Vitamin D / Q000378:metabolism*
D004100:Dihydroxycholecalciferols; D014807:Vitamin D; D002117:Calcitriol; D002112:Calcifediol; C026032:25,26-dihydroxycholecalciferol