Amino terminal fragments of human progastrin from gastrinoma.
Two peptides which copurified from a human gastrinoma were found to correspond to the amino acid sequence deduced for the amino terminal portion of human and porcine progastrin. The sequence of peptide A is Ser-Trp-Lys-Pro-Arg-Ser-Gln-Gln-Pro-Asp-Ala-Pro-Leu-Gly-Thr-Gly-Ala-Asn- Arg-Asp-Leu-Glu-Leu which is identical to an amino terminal portion of human progastrin. The sequence of peptide. B is identical to that of peptide A except it is missing the first five amino acids. If peptide A corresponds to the amino terminus of progastrin, the signal peptidase cleaves at an Ala-Ser bond.
D000595:Amino Acid Sequence; D000818:Animals; D005755:Gastrins / Q000235:genetics / Q000302:isolation & purification*; D005796:Genes; D006801:Humans; D010446:Peptide Fragments / Q000032:analysis; D011498:Protein Precursors / Q000235:genetics / Q000302:isolation & purification*; D013045:Species Specificity; D013552:Swine; D015043:Zollinger-Ellison Syndrome / Q000032:analysis*
D005755:Gastrins; D010446:Peptide Fragments; D011498:Protein Precursors; C013706:big gastrin