Prevention by macrocortin of global cerebral ischemia in Sprague-Dawley rats.
We have previously shown that dexamethasone protects female Sprague-Dawley CFY rats against global cerebral ischemia induced by bilateral carotid artery ligation. In the present study, macrocortin derived from rat peritoneal cells exposed to dexamethasone was found to exhibit antiphospholipase A2 activity and to provide significant protection against the fatal consequences of carotid artery ligation. These results suggest that the cerebroprotective effect of glucocorticoids may be related to macrocortin production.
D000818:Animals; D001834:Body Water / Q000032:analysis; D002545:Brain Ischemia / Q000378:metabolism / Q000517:prevention & control*; D005260:Female; D006023:Glycoproteins; D047908:Intracellular Signaling Peptides and Proteins; D010455:Peptides / Q000627:therapeutic use*; D010740:Phospholipases / Q000037:antagonists & inhibitors*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains
D006023:Glycoproteins; D047908:Intracellular Signaling Peptides and Proteins; D010455:Peptides; C027564:macrocortin protein, rat; D010740:Phospholipases; D010741:Phospholipases A