[Fungal infections: involved species and minimal inhibitory concentrations of common antifungal agents].
Fungal cultures of cutaneous or ungual origin (477 cultures), nasopharyngeal and urogenital origin (2,000 cultures), and blood, internal organs, surgical incisions, and catheters (300 cultures) were obtained in this study. Analysis of the data yielded the following information: Candida albicans and C. tropicalis, frequent causes of superficial or systemic mycoses, were very sensitive to flucytosine and amphotericin B in a liquid medium, but less sensitive to the imidazole derivatives; C. parapsilosis, a cause of superficial and systemic mycoses, was remarkably sensitive to all four antifungal agents tested; Torulopsis glabrata and C. krusei are of greatest concern in a hospital setting since systemic or visceral infections are minimally sensitive to antifungal agents; C. pseudotropicalis, C. guilliermondii, and C. zeylanoides are less pathogenic and sensitive to antifungal agents varies, depending on the strain. Specific measures are presented for management of fungal infections in a hospital setting. The role of antifungal susceptibility testing in everyday practice is also evaluated.
D000666:Amphotericin B / Q000494:pharmacology; D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects* / Q000302:isolation & purification; D002177:Candidiasis / Q000188:drug therapy / Q000382:microbiology; D003428:Cross Infection / Q000188:drug therapy; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009181:Mycoses / Q000188:drug therapy
D000935:Antifungal Agents; D007093:Imidazoles; D000666:Amphotericin B
Infections à levures: espèces concernées et concentrations minimales inhibitrices des antifongiques usuels.