Platelet dysfunction in acute megakaryoblastic leukemia.
Acute megakaryoblastic leukemia occurred in an adolescent. There was considerable bleeding despite only moderate thrombocytopenia, and both platelet structure and platelet function were abnormal. To our knowledge, platelet dysfunction has only once been documented in this acute leukemia, although in other leukemias with megakaryocytic predominance, notable bleeding has been observed in the absence of thrombocytopenia.
D000293:Adolescent; D001792:Blood Platelets / Q000473:pathology*; D006801:Humans; D008297:Male; D010974:Platelet Aggregation; D013920:Thrombocythemia, Essential / Q000473:pathology* / Q000503:physiopathology