Effect on contractility of skinned fibres from mammalian heart and smooth muscle by a new benzimidazole derivative, 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]-5-methy l-3(2H )- pyridazinone.
The positive inotropic drug 4,5-dihydro-6-[2-(4-methoxyphenyl)-1H-benzimidazol-5-yl]methyl-3(2 H)- pyridazinone (UD-CG 115 BS) enhances calcium induced contraction of skinned fibres from cardiac muscle probably by increasing the calcium sensitivity of troponin. Submaximal calcium induced contraction of skinned fibres from a smooth muscle (guinea-pig taenia coli) are slightly inhibited.
D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology*; D003106:Colon / Q000187:drug effects; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects*; D011724:Pyridazines / Q000494:pharmacology*; D013552:Swine
D002316:Cardiotonic Agents; D011724:Pyridazines; C041648:pimobendan