Hepatic actions of progestogenic steroids.
The effects of two oral progestogens, norethisterone and d-norgestrel, were studied on hepatic functions in CFY female rats. In healthy animals both progestogens inhibited cytochrome-P-450 dependent nonspecific mixed function monooxygenases. Serum bilirubin and cholylglycin RIA values were normal. Protein and glycogen content of the liver remained intact after norethisterone, d-norgestrel reduced glycogen. The pathologic values characteristic for chronic carbon-tetrachloride damage improved on a highly significant grade when these progestogens were simultaneously administered. The progestogens inhibited mixed function monooxygenases. We may presume that in this way they inhibited the formation of hepatotoxic trichloromethyl free radical and improved several liver functions.
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D001663:Bilirubin / Q000097:blood; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003573:Cytochrome b Group / Q000378:metabolism; D015786:Cytochromes b5; D005260:Female; D008099:Liver / Q000187:drug effects*; D008112:Liver Glycogen / Q000378:metabolism; D008862:Microsomes, Liver / Q000201:enzymology; D009640:Norethindrone / Q000494:pharmacology; D009644:Norgestrel / Q000494:pharmacology; D011372:Progestins / Q000494:pharmacology*; D011863:Radioimmunoassay; D051381:Rats; D012890:Sleep / Q000187:drug effects
D003573:Cytochrome b Group; D008112:Liver Glycogen; D011372:Progestins; D009644:Norgestrel; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D000633:Aminopyrine N-Demethylase; D001663:Bilirubin; D009640:Norethindrone