3-Methylindole-induced pulmonary injury in lambs. A comparison with acute respiratory distress syndrome (ARDS).
Five to six month-old lambs of two different Norwegian breeds (Dala and Rygja) were dosed with 3-methyl indole (3MI) and DL-tryptophan (DL-T), and examined clinically, hematologically and post mortem. Results were compared with the findings in Acute Respiratory Distress Syndrome (ARDS), a condition of acute dyspnea occurring in 5-6 month-old lambs (of Dala and Spael breeds) after they have been moved from mountain pastures onto lush aftermath in September. The results show that such young Norwegian lambs are susceptible to 3MI-dosing, and that the symptoms and lesions were similar to those described earlier in connection with 3MI-dosing in cattle and adult sheep. The results clearly demonstrate that 3-MI-induced pulmonary injury in lambs differs from ARDS as far as both symptoms, hematology and pathology are concerned.
D000208:Acute Disease; D000818:Animals; D006801:Humans; D007211:Indoles / Q000009:adverse effects*; D007231:Infant, Newborn; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced*; D012127:Respiratory Distress Syndrome, Newborn / Q000473:pathology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced*; D012862:Skatole / Q000009:adverse effects*
D007211:Indoles; D012862:Skatole