Acyl-kallikrein; a delivery system for the kinin-liberating enzyme.
Glandular kallikrein can be temporarily acylated at the active centre by 4-amidinophenyl benzoates. The time course of reactivation depends on the nature of the acyl group introduced. Benzoyl kallikrein was used as a delivery system for kallikrein in vivo. In rabbits, bolus injection of the acylated enzyme caused a long-lasting drop in blood pressure due to sustained kinin liberation.
D000215:Acylation; D000818:Animals; D001550:Benzamidines; D001794:Blood Pressure / Q000187:drug effects; D004789:Enzyme Activation; D005260:Female; D007610:Kallikreins / Q000008:administration & dosage* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D011817:Rabbits; D013329:Structure-Activity Relationship
D001550:Benzamidines; C006491:4-amidinophenylbenzoate; D007610:Kallikreins