Investigation of the antitumor activity of new epoxide derivatives. Part I: s-Triazinetrione derivatives.
The noteworthy cytostatic activity of triglycidyl-s-triazinetrione and the planned clinical testing of this new active substance induced us to subject this class of substances to closer examination. By chemical reaction of one of the three glycidyl groups present it was possible to introduce wide variations in the properties of the compounds, whilst still retaining the active principle. A number of these substances possessed very high antitumor activity as revealed in the leukemia screening test (P 388; mouse). The influence of other substituents within the glycidyl groups affecting the reactivity of the epoxides groups was also examined.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D001681:Biological Assay; D055598:Chemical Phenomena; D002621:Chemistry; D006863:Hydrogen-Ion Concentration; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D010084:Oxidation-Reduction; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D014227:Triazines; C028786:teroxirone