Cytotoxic changes induced in rat-liver cells by short-term exposure to acetylethyltetramethyltetralin.
The livers of Sprague-Dawley female rats examined by electron microscopy after oral administration of one, two or three doses of acetylethyltetramethyltetralin (AETT) demonstrated that this compound is a hepatotoxin which induces classic degenerative changes as well as effects on the nucleolus. This suggests that AETT not only affects cytoplasmic homeostasis but may also have an effect upon protein synthesis.
D000284:Administration, Oral; D000818:Animals; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D006706:Homeostasis / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008854:Microscopy, Electron; D009281:Naphthalenes / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013764:Tetrahydronaphthalenes / Q000633:toxicity*
D009281:Naphthalenes; D013764:Tetrahydronaphthalenes; C023054:versalide