Protein C level at birth.
The protein C level was determined, on cord blood, for 30 healthy newborns by electro-immuno assay using a monospecific antiserum. For the newborns the mean level of protein C related antigen is about one third of normal adults' mean level. There is a good correlation between Protein C related antigen and prothrombin related antigen. The low level of these vitamin-K-dependent proteins is probably a consequence of partial liver immaturity at birth. Using two-dimensional immuno-electrophoresis we were unable to detect subcarboxylated forms of protein C. However these abnormal forms could be seen in vitamin-K deficiencies of neonates.
D000284:Administration, Oral; D000328:Adult; D000367:Age Factors; D000925:Anticoagulants / Q000008:administration & dosage / Q000494:pharmacology; D000941:Antigens / Q000032:analysis; D001779:Blood Coagulation Factors / Q000032:analysis*; D001798:Blood Proteins / Q000032:analysis*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006023:Glycoproteins / Q000097:blood* / Q000276:immunology; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D007231:Infant, Newborn; D007275:Injections, Intravenous; D011486:Protein C; D011516:Prothrombin / Q000276:immunology; D014812:Vitamin K / Q000008:administration & dosage; D014813:Vitamin K Deficiency / Q000097:blood / Q000188:drug therapy
D000925:Anticoagulants; D000941:Antigens; D001779:Blood Coagulation Factors; D001798:Blood Proteins; D006023:Glycoproteins; D011486:Protein C; D014812:Vitamin K; D011516:Prothrombin