title: Ototoxicity and noise-drug interaction.
abstract: Diverse therapeutic agents, such as certain antibiotics, diuretics, and analgesics can cause functional and morphological damage to the inner ear. Noise present in recreational or occupational environment may also be potentially damaging to the auditory system when combined with some ototoxic therapeutic agents. This article documents recent research and controversies about the site and mechanism of action of major ototoxic drugs, noise-drug interaction, and possible prophylaxis against such ototoxicity.
mesh_terms: D000328:Adult; D000617:Aminoglycosides / Q000009:adverse effects; D000818:Animals; D000900:Anti-Bacterial Agents / Q000009:adverse effects; D002648:Child; D003051:Cochlea / Q000187:drug effects*; D004232:Diuretics / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D004785:Environmental Pollutants / Q000009:adverse effects; D005260:Female; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects; D006199:Hair Cells, Auditory, Inner / Q000187:drug effects; D006311:Hearing Disorders / Q000139:chemically induced*; D006317:Hearing Loss, Noise-Induced; D006801:Humans; D007231:Infant, Newborn; D007612:Kanamycin / Q000009:adverse effects; D009925:Organ of Corti / Q000187:drug effects; D011803:Quinine / Q000009:adverse effects; D012306:Risk; D012459:Salicylates / Q000009:adverse effects
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D004232:Diuretics; D004785:Environmental Pollutants; D012459:Salicylates; D007612:Kanamycin; D011803:Quinine