title: [Simulation modeling of the initiation of tumor growth in continually renewed cell systems].
abstract: A discrete stochastic model of simulation of a cell renewal system is discussed. The model is based on a functional approach to the present-day concepts on the nature of processes of cell proliferation and differentiation as well as mechanisms responsible for integration of these processes. Due to application of specialized programming means of simulation (language GPSS /360) a complete functional pattern of maintenance of cell-population homeostasis in tissue was reproduced. Disturbances in certain mechanisms of intra-tissue regulatory system accompanied by formation of tumor growth foci were simulated experimentally.
mesh_terms: D000818:Animals; D002453:Cell Cycle; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D002478:Cells, Cultured; D007414:Intestinal Neoplasms / Q000473:pathology; D007422:Intestines / Q000473:pathology; D008938:Mitosis; D008954:Models, Biological; D014411:Neoplastic Stem Cells / Q000473:pathology; D012984:Software; D013269:Stochastic Processes; D013997:Time Factors
vernacular_title: Imitatsionnoe modelirovanie initsiatsii opukholevogo rosta v nepreryvno obnovliaiushchikhsia kletochnykh sistemakh.