title: Sakyomicins A, B, C and D: new quinone-type antibiotics produced by a strain of Nocardia. Taxonomy, production, isolation and biological properties.
abstract: Actinomycete strain M-53, a new soil isolate, was found to produce four quinone-type antibiotics. Antibiotic sakyomicin components, A, B, C and D were isolated from the fermentation broth of strain M-53 by XAD-2 column chromatography, silica gel column chromatography and Sephadex LH-20 column chromatography. The components are active against Gram-positive bacteria. Strain M-53 was identified as a strain of genus Nocardia.
mesh_terms: D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D016227:Benzoquinones; D008826:Microbial Sensitivity Tests; D009615:Nocardia / Q000032:analysis; D011809:Quinones / Q000302:isolation & purification / Q000494:pharmacology; D014961:X-Ray Diffraction
chemical_list: D000900:Anti-Bacterial Agents; D016227:Benzoquinones; D011809:Quinones; C042536:sakyomicin A; C042538:sakyomicin C; C042539:sakyomicin D; C042537:sakyomicin B