title: Methicillin-resistant Staphylococcus epidermidis blepharitis.
abstract: Blepharoconjunctivitis caused by methicillin-resistant strains of Staphylococcus epidermidis occurred in two hospitalized patients, a 74-year-old man and a 19-year-old man. Both strains were resistant to multiple courses of topical antibiotic therapy. Successful treatment in both cases depended upon antibiotic sensitivity testing. These methicillin-resistant strains of S. epidermidis, like methicillin-resistant strains of Staphylococcus aureus, demonstrated almost complete cross-resistance to cephalosporins despite apparent sensitivity on Kirby-Bauer disk sensitivity testing. Topical vancomycin was curative in one case. In the other case, treatment with topical gentamicin, intravenous cefoperazone, and oral rifampin led to resolution of the symptoms.
mesh_terms: D000328:Adult; D000368:Aged; D001762:Blepharitis / Q000188:drug therapy*; D005141:Eyelid Diseases / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008712:Methicillin / Q000627:therapeutic use*; D010403:Penicillin Resistance; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013212:Staphylococcus epidermidis
chemical_list: D008712:Methicillin