Pharmacological and toxicological investigations of cesium.
Cesium, a mineral resource abundantly present in Manitoba with important existing and potential industrial applications was investigated to study its effects on biological systems. Several rodent models of pharmacological activities were utilized. The profile that emerged indicated that cesium is only moderately toxic and exerts salubrious effects which could be gainfully investigated for application in the treatment of certain psychological disorders and some tumors. Its conjunction with existing pharmacological agents for these two types of disorders could yield a pharmacologically active yet less toxic therapeutic combination.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D001564:Benzo(a)pyrene; D001794:Blood Pressure / Q000187:drug effects; D002375:Catalepsy / Q000139:chemically induced; D002586:Cesium / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity; D004357:Drug Synergism; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D008274:Magnesium / Q000494:pharmacology; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism; D011619:Psychotropic Drugs / Q000494:pharmacology; D012640:Seizures / Q000139:chemically induced; D012878:Skin Neoplasms / Q000139:chemically induced / Q000188:drug therapy
D011619:Psychotropic Drugs; D002586:Cesium; D001564:Benzo(a)pyrene; D008274:Magnesium; D005947:Glucose