Skin-tumour promoting activity of methyl ethyl ketone peroxide--a potent lipid-peroxidizing agent.
The tumour-promoting activity of methyl ethyl ketone peroxide (MEKP) was tested on the skin of hairless mice using a two-stage initiation-promotion protocol. When ultraviolet radiation in the UVB region (280-320 nm) was used as tumour initiator, MEKP showed weak promoting activity. The promotional activity of MEKP was potentiated by diethyl maleate, which is known to deplete intracellular glutathione, suggesting that lipid peroxidation may be important in the tumour promotion.
D000096:Acetone / Q000633:toxicity; D000287:Administration, Topical; D000818:Animals; D002074:Butanones / Q000633:toxicity*; D002273:Carcinogens / Q000633:toxicity*; D003993:Dibutyl Phthalate / Q000633:toxicity; D004357:Drug Synergism; D005260:Female; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008298:Maleates / Q000633:toxicity; D051379:Mice; D008812:Mice, Hairless; D010545:Peroxides / Q000633:toxicity*; D012878:Skin Neoplasms / Q000139:chemically induced*; D014466:Ultraviolet Rays / Q000009:adverse effects*
D002074:Butanones; D002273:Carcinogens; D008054:Lipid Peroxides; D008298:Maleates; D010545:Peroxides; C011007:methyl ethyl ketone peroxide; D000096:Acetone; D003993:Dibutyl Phthalate; C014476:diethyl maleate