Investigation of coffee in sister chromatid exchange and micronucleus tests in vivo.
Administration of a single oral dose of instant coffee to Chinese hamsters at levels up to 2.5 g/kg body weight did not increase the frequency of sister chromatid exchanges. Furthermore, five consecutive daily oral doses of instant coffee given to Swiss OF-1 mice up to 3 g/kg/day did not induce increases in micronuclei above spontaneous levels. Similarly, no effect was observed in the micronucleus test after mice received two oral doses of coffee aroma of up to 50 ml/kg.
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects* / Q000648:ultrastructure; D003069:Coffee / Q000633:toxicity*; D006224:Cricetinae; D003412:Cricetulus; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D003069:Coffee; D009153:Mutagens