title: A double-blind controlled evaluation of the nasal decongestant effect of Day Nurse in the common cold.
abstract: A rhinomanometric technique was used to evaluate the nasal decongestant effect of a single dose of Day Nurse over a 4-hour post-dosing period in human volunteers suffering from nasal congestion due to a common cold. A significant improvement in nasal congestion was obtained at the 1 hour, 2 hour, 3 hour and 4 hour post-dosing interval, from initial values compared to a placebo group. The study therefore demonstrated by an objective technique that Day Nurse provides relief of nasal congestion and related symptoms in cold sufferers.
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001205:Ascorbic Acid / Q000627:therapeutic use*; D003061:Codeine / Q000031:analogs & derivatives; D003139:Common Cold / Q000188:drug therapy* / Q000503:physiopathology; D003915:Dextromethorphan / Q000627:therapeutic use*; D004311:Double-Blind Method; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007981:Levorphanol / Q000031:analogs & derivatives*; D008297:Male; D008365:Manometry; D008875:Middle Aged; D057985:Multi-Ingredient Cold, Flu, and Allergy Medications; D009666:Nose / Q000503:physiopathology; D010665:Phenylpropanolamine / Q000627:therapeutic use*; D011312:Pressure; D054199:Pseudoephedrine; D011897:Random Allocation; D013997:Time Factors
chemical_list: D004338:Drug Combinations; D057985:Multi-Ingredient Cold, Flu, and Allergy Medications; C041604:acetaminophen, pholcodine, pseudoephedrine drug combination; D007981:Levorphanol; D010665:Phenylpropanolamine; D000082:Acetaminophen; D003915:Dextromethorphan; D054199:Pseudoephedrine; D001205:Ascorbic Acid; D003061:Codeine