Synthesis and biophysical studies of short oligodeoxynucleotides with novel modifications: a possible approach to the problem of mixed base oligodeoxynucleotide synthesis.
The syntheses of 1,2-dideoxy-D-ribofuranose and 1,2-dideoxy-1-phenyl-beta-D-ribofuranose are described. Oligodeoxynucleotides containing these analogues have been synthesised and hybridized to their complementary strands. Hypochromicity studies have shown that these duplices are less stable than either the totally complementary duplex or those containing A.C and G.T mismatches.
D003855:Deoxyribose / Q000031:analogs & derivatives / Q000138:chemical synthesis; D005815:Genetic Code; D009693:Nucleic Acid Hybridization; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D009841:Oligonucleotides / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D003855:Deoxyribose; C043138:1,2-dideoxyribofuranose; C043137:1,2-dideoxy-1-phenyl-beta ribofuranose