title: Ethoxzolamide analogue gel. A topical carbonic anhydrase inhibitor.
abstract: An analogue of ethoxzolamide, 6-hydroxyethoxzolamide, was synthesized to enhance corneal permeability yet retain carbonic anhydrase inhibitory activity for use in lowering intraocular pressure. In a 1% suspension, the analogue caused a small but statistically significant unilateral reduction of IOP when applied to one eye of normal rabbits. When formulated in a gel vehicle, 6-hydroxyethoxzolamide caused a more prolonged and larger reduction in IOP in normal and ocular hypertensive rabbits compared with its effect in suspension or with the parent compound.
mesh_terms: D000818:Animals; D052160:Benzothiazoles; D002257:Carbonic Anhydrase Inhibitors; D002918:Chymotrypsin; D005016:Ethoxzolamide / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D005782:Gels; D005901:Glaucoma / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D007429:Intraocular Pressure / Q000187:drug effects*; D009883:Ophthalmic Solutions; D011817:Rabbits; D013535:Suspensions; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D052160:Benzothiazoles; D002257:Carbonic Anhydrase Inhibitors; D005782:Gels; D009883:Ophthalmic Solutions; D013535:Suspensions; D013844:Thiazoles; C043694:6-hydroxyethoxzolamide; D002918:Chymotrypsin; D005016:Ethoxzolamide