Trinitrotoluene-induced effects on rat heme metabolism.
A single injection (100 mg/kg body wt) of trinitrotoluene in rats caused decreased delta-aminolevulinic acid synthase activity in reticulocytes and decreased erythrocyte coproporphyrin concentration 48 hr after the intraperitoneal dosage. For comparison, liver delta-aminolevulinic acid synthase was unaffected while heme synthase activity was below the control range at the same time. Heme oxygenase activity increased simultaneously. These effects are likely to lead to a negative heme balance and may be developed for a biological exposure test to trinitrotoluene in occupational health service.
D000624:5-Aminolevulinate Synthetase / Q000097:blood; D000818:Animals; D003306:Coproporphyrins / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005294:Ferrochelatase / Q000378:metabolism; D006418:Heme / Q000378:metabolism*; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012156:Reticulocytes / Q000201:enzymology; D014303:Trinitrotoluene / Q000494:pharmacology*
D003306:Coproporphyrins; D014303:Trinitrotoluene; D006418:Heme; D006419:Heme Oxygenase (Decyclizing); D000624:5-Aminolevulinate Synthetase; D005294:Ferrochelatase