title: [Formation of nicotine addiction in mongrel white rats].
abstract: A study was made of the possibility of forming nicotine addiction in laboratory rats and using it as the basis for the design of experimental nicotine toxicomania. Experiments were carried out on 56 rats placed in individual cages with a possibility of free choice between water and 0.005% nicotine solution for 2 to 4 months. It was established that the population of intact laboratory rats with 8- and 16-week contact with nicotine solution could be divided into groups demonstrating 3 main types of attitude toward nicotine: aversion (68% of all the animals), moderate addiction (4%), and pronounced addiction (28%). These quantitative relationships remained unchanged whatever the time of contact with nicotine. Thus, the possibility has been shown of designing experimental nicotine toxicomania with marked elements of physical dependence in rats consuming nicotine on a voluntary basis.
mesh_terms: D000818:Animals; D003042:Cocaine; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects; D006801:Humans; D008297:Male; D009538:Nicotine; D051381:Rats; D019966:Substance-Related Disorders / Q000209:etiology*; D013997:Time Factors
chemical_list: D009538:Nicotine; D003042:Cocaine
vernacular_title: Formirovanie vlecheniia k nikotinu u belykh besporodnykh krys.