title: Reduced glandular kallikrein-like activity in the anterior pituitary of the New Zealand genetically hypertensive rat.
abstract: Anterior pituitaries of New Zealand genetically hypertensive and normotensive rats were compared for their content of glandular kallikrein-like activity. Anterior pituitary homogenates were assayed for their ability to cleave a chromogenic peptide substrate for glandular kallikrein (H-D-val-leu-arg-p-nitroanilide) at pH 8.0. Anterior pituitaries of both male and female New Zealand genetically hypertensive rats contained significantly less glandular kallikrein-like activity than their normotensive counterparts (-55% for females and -31% for males).
mesh_terms: D000818:Animals; D005260:Female; D006973:Hypertension / Q000201:enzymology* / Q000235:genetics; D007610:Kallikreins / Q000378:metabolism*; D008297:Male; D010903:Pituitary Gland, Anterior / Q000201:enzymology*; D051381:Rats; D011922:Rats, Mutant Strains; D012016:Reference Values; D012737:Sex Factors
chemical_list: D007610:Kallikreins