Prevention of neonatal hyperbilirubinemia in rhesus monkeys by tin-protoporphyrin.
Rhesus monkey infants were injected subcutaneously at birth with 12 to 100 mumol of tin-protoporphyrin IX, a competitive inhibitor of microsomal heme oxygenase. The elevated unconjugated serum bilirubin levels of the neonates receiving this metalloporphyrin rapidly declined to near adult levels by 24-30 h. Control neonates which received an injection of saline exhibited normal physiologic hyperbilirubinemias of from 3-6 mg/dl by 12-24 h as expected. These studies establish the effectiveness of tin-protoporphyrin IX in depressing bilirubin production and preventing physiologic hyperbilirubinemia in simian neonates. Two of six animals receiving the metalloporphyrin exhibited signs of toxicity.
D000818:Animals; D001663:Bilirubin / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000517:prevention & control*; D008253:Macaca mulatta; D008665:Metalloporphyrins; D011166:Porphyrins / Q000627:therapeutic use*; D011524:Protoporphyrins / Q000627:therapeutic use* / Q000633:toxicity
D008665:Metalloporphyrins; D011166:Porphyrins; D011524:Protoporphyrins; C032628:tin protoporphyrin IX; D001663:Bilirubin