Drug resistance induction and cross-resistance studies with Pt-complexes.
In vitro drug resistance was induced against cis-diamminedichloroplatinum(II) (cis-DDP), 1,2-diaminocyclohexaneplatinum-(II)citrate (PEX) and 1,2-diaminocyclohexaneplatinum(II)glucarate (PTU) in L1210 leukemia cell line. Using the resistant sublines cross-resistance was found between cis-DDP and cis-diamminecyclobutane-1,1-dicarboxylatoplatinum(II) (CBDCA) and between the three 1,2-diaminocyclohexane (DACH) derivatives tested. No (or low degree) cross-resistance was found between cis-DDP and DACH derivatives.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002945:Cisplatin / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000235:genetics; D051379:Mice; D009944:Organoplatinum Compounds / Q000627:therapeutic use*; D010984:Platinum
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D010984:Platinum; C044245:1,2-diaminocyclohexaneplatinum II citrate; C044244:platuran; D002945:Cisplatin