Cellular and humoral immune parameters among patients with retinitis pigmentosa and other retinal disorders.
Patients with retinitis pigmentosa, other retinal degenerations and a group of normal volunteers were included in a masked study designed to examine the existence of autoimmune reactions toward retinal antigens and the possible defect in lymphokine production (IL-1, IL-2 and gamma interferon). The results obtained did not show any specific anamnestic response to the retinal S-Ag nor any outstanding defect in gamma interferon production by the lymphocytes of patients with retinitis pigmentosa. It is suggested that a larger masked study be conducted as soon as possible in order to clarify these aspects of immune aberrations in patients with retinitis pigmentosa.
D000917:Antibody Formation; D001327:Autoimmune Diseases / Q000150:complications; D006801:Humans; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008222:Lymphokines / Q000032:analysis; D012016:Reference Values; D012164:Retinal Diseases / Q000276:immunology*; D012174:Retinitis Pigmentosa / Q000276:immunology*
D008222:Lymphokines