Absorption and circular dichroism studies of a gold (I)-DNA complex.
The DNA binding properties of the Au(I)-containing antiarthritic drug Ridaura and related Au(I) complexes have been investigated. Absorption and circular dichroism spectroscopy show that if the gold ion possesses an easily displaced ligand, e.g., Cl- or Br-, Au(I) is capable of interacting, in a nondenaturing fashion, with calf thymus DNA. Absorption studies with the four DNA nucleosides suggest that guanine and cytosine bases are important in the Au(I)DNA interaction.
D000818:Animals; D002417:Cattle; D002942:Circular Dichroism / Q000379:methods; D004247:DNA / Q000032:analysis*; D006046:Gold / Q000032:analysis*; D009705:Nucleosides / Q000032:analysis; D050607:Organogold Compounds; D009942:Organometallic Compounds; D010720:Phosphines; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013950:Thymus Gland
D009705:Nucleosides; D050607:Organogold Compounds; D009942:Organometallic Compounds; D010720:Phosphines; C041632:triethylphosphine gold bromide; C016797:triethyl phosphine gold; D006046:Gold; D004247:DNA