Indomethacin suppression of the estradiol-induced proliferative response of the seminal vesicles.
Effects of indomethacin (1.25 mg/kg of body weight and 1.25 mg/rat) on estradiol-induced (250 micrograms/rat and 25 micrograms/rat) mitotic activity of the seminal vesicles and the ventral prostate in rats were examined. The obtained results show clearly that indomethacin restrains the seminal vesicles proliferative reaction induced by estradiol, whereas the ventral prostate is not sensitive to estradiol, and indomethacin does not affect its mitotic activity. These results suggest that prostaglandins are involved in the mitogenic effect of estradiol on the seminal vesicles.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D004965:Estrogen Antagonists; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D008940:Mitotic Index / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012669:Seminal Vesicles / Q000166:cytology* / Q000187:drug effects
D004965:Estrogen Antagonists; D004958:Estradiol; D007213:Indomethacin