Elimination of toxicity from diets containing alfalfa seeds.
Cynomolgus macaques were fed autoclaved alfalfa seeds for up to 1 yr. There were no humoral signs of a syndrome resembling systemic lupus erythematosus. The data are in contrast to those previously reported in monkeys fed raw alfalfa seeds, in which a systemic lupus erythematosus-like syndrome was induced in a shorter interval. The autoclaved seeds retained antihypercholesterolaemic effects.
D000740:Anemia / Q000209:etiology; D000821:Animal Feed / Q000633:toxicity; D000818:Animals; D001327:Autoimmune Diseases / Q000209:etiology; D002172:Canavanine / Q000032:analysis / Q000633:toxicity; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D005260:Female; D006358:Hot Temperature; D006937:Hypercholesterolemia / Q000517:prevention & control; D007074:Immunoglobulin G / Q000032:analysis; D008180:Lupus Erythematosus, Systemic / Q000209:etiology; D008252:Macaca fascicularis; D000455:Medicago sativa / Q000032:analysis / Q000633:toxicity*; D010945:Plants, Edible / Q000032:analysis; D012639:Seeds / Q000032:analysis
D003176:Complement C3; D003181:Complement C4; D007074:Immunoglobulin G; D002172:Canavanine