[Effect of polypeptide factors of the thymus, pineal gland, bone marrow and anterior hypothalamus on the realization of transplacental carcinogenesis].
The postnatal action of low-molecular polypeptide factors of thymus (FT), pineal gland (FP), bone marrow (FRM) and anterior hypothalamus (FAH) on transplacental carcinogenic effect of N-nitroso-N-ethylurea in rats was studied. Both FT and FP administrations decreased incidence and multiplicity of tumours and prolonged their mean latent periods. These drugs inhibited mainly the development of tumours of the spinal cord, kidneys and peripheral nervous system but not those of the brain. Both FBM and FAH had no significant influence on transplacental carcinogenesis. FT and FP anticarcinogenic effect is supposed to be due to their normalizing action on hormonal metabolic and immunological shifts arising in the body after transplacental administration of the carcinogen.
D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D005038:Ethylnitrosourea; D005260:Female; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control; D010455:Peptides / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D013120:Spinal Cord Neoplasms / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D013951:Thymus Hormones / Q000494:pharmacology*
D010455:Peptides; D013951:Thymus Hormones; C027437:epithalamin; C032805:thymalin; D005038:Ethylnitrosourea
Vliianie polipeptidnykh faktorov timusa, épifiza, kostnogo mozga i perednego gipotalamusa na realizatsiiu transplatsentarnogo kantserogeneza.