title: [High levels of manganese in the diet of rats (Rattus norvegicus albinicus). I. Effect on reproduction].
abstract: The present trial was conducted to obtain more information on the ingestion of diets containing high levels of manganese, and thus, elucidate its toxic effects on animal performance under field conditions. This paper represents a preliminary and systematic laboratory investigation carried out in rats and their offspring. The animals were fed diets with basal Mn levels of 50 ppm (0.91 mM) plus the addition of 0, 500 and 1,000 ppm Mn (on a dry basis) for each group included in the experiment, and observing the appearance of toxic effects up to 7.5 months of treatment. A failure in reproductive performance was noted, as well as in growth and survival of neonates. Histological studies of the testes and ovaries showed a reduction of spermatogenesis, epithelial alterations, atresic follicles, and persistence of corpus luteum, indicative of a disfunction of the sexual glands.
mesh_terms: D000818:Animals; D004032:Diet; D005260:Female; D005526:Food, Formulated; D006066:Gonads / Q000473:pathology / Q000502:physiology; D008297:Male; D020149:Manganese Poisoning; D010060:Ovulation / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects*
vernacular_title: Altos niveles de manganeso en la dieta de ratas (Rattus norvegicus albinicus). I. Efecto sobre la reproduccion.