Effect of TEI-4120 (3-benzoyl-N-beta-ethoxyisopropyl-2-methlindole) on carrageenan induced disseminated intravascular coagulation (DIC) in rats.
In order to evaluate TEI-4120 (3-benzoyl-N-beta-ethoxyisopropyl-2-methylindole), as a possible therapheutic compound to disseminated intravascular coagulation (DIC), DIC model in rats was induced by the treatment of lambda-carrageenan according to the method of Sugiyama et al. with minor modification. Two hours after intraperitoneal injection of lambda-carrageenan, plasma fibrinogen decreased and platelet count, prothrombin time, serial thrombin time and plasma TXB2 prolonged or increased. By use of this model, the activities of TEI-4120, new antithrombotic compound, was evaluated compared with three other compounds, aspirin, warfarin and heparin. As a result, TEI-4120 is effective in this model. Combination therapy of TEI-4120 and warfarin is more effective than single administration of TEI-4120. The effect of combination therapy of TEI-4120 and warfarin is consistent with that of heparin. The above result suggests that TEI-4120 seems to be a promising compound to the therapy of DIC.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001760:Bleeding Time; D002351:Carrageenan; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology; D007211:Indoles / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013929:Thromboxane B2 / Q000037:antagonists & inhibitors; D014859:Warfarin / Q000494:pharmacology
D005343:Fibrinolytic Agents; D007211:Indoles; D013929:Thromboxane B2; D014859:Warfarin; C033778:3-benzoyl-N-beta-ethoxyisopropyl-2-methylindole; D002351:Carrageenan; D006493:Heparin; D001241:Aspirin