Inhibition of gonadotropin and prostaglandin stimulation of testicular steroidogenesis in malnourished rats.
The effect of human chorionic gonadotropin (hCG) and prostaglandin E1 (PGE1) on testicular steroidogenesis in protein-deficient and refed rats was studied in vitro. The malnourished, refed, and control rats were found to secret testosterone in response to hCG and PGE1 stimulation. There was a significant reduction in the basal level of secretion in the malnourished rat testis (1.0 +/- 0.4 nMol/3 hr./Testis). Malnourished rats refed with adequate protein diet responded to hCG and PGE1 stimulation in a similar manner to normally-fed adult rats.
D000527:Alprostadil; D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D004044:Dietary Proteins / Q000008:administration & dosage*; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000378:metabolism*; D013739:Testosterone / Q000096:biosynthesis
D006063:Chorionic Gonadotropin; D004044:Dietary Proteins; D011458:Prostaglandins E; D013739:Testosterone; D000527:Alprostadil