Librium prevents the analgesia and shuttlebox escape deficit typically observed following inescapable shock.
Administration of a benzodiazepine, chlordiazepoxide (CDP), prior to exposure to inescapable shock prevented both the long-term analgesia and the shuttle-escape deficit typically observed following inescapable shock. If given only prior to testing, CDP had little effect. The protective effects of CDP were determined not to be a result of state dependency or a general facilitatory effect of the drug on escape performance. It is suggested that the induction of anxiety or fear by inescapable shock is critical in mobilizing endogenous changes such as transmitter depletion which are thought to be responsible for the deficits observed.
D000698:Analgesia; D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004361:Drug Tolerance; D004597:Electroshock; D004924:Escape Reaction / Q000187:drug effects*; D006380:Helplessness, Learned; D006801:Humans; D008297:Male; D051381:Rats; D011930:Reaction Time / Q000187:drug effects
D002707:Chlordiazepoxide