title: Some effects of the formamidine pesticide chlordimeform on the behavior of mice.
abstract: Three experiments were performed to determine the behavioral effects of acutely administered chlordimeform (1-56 mg/kg, i.p.) to male mice. In Experiment I, dosages of 30 and 56 mg/kg decreased the amount of time spent investigating a female conspecific. In Experiment II, large dosages of chlordimeform (30 and 56 mg/kg) decreased vertically directed activity (rearing) to a proportionately greater extent than horizontally directed activity (ambulation). In Experiment III, chlordimeform produced conditioned flavor aversions that were intermediate at 10 mg/kg and maximal at 30 mg/kg. In an additional experiment (Experiment IV), the LD50 for chlordimeform was determined to be 95.6 mg/kg. Behavioral effects were thus obtained at dosages that were approximately 10 to 30% of the LD50.
mesh_terms: D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D002742:Chlorphenamidine / Q000494:pharmacology* / Q000633:toxicity; D005106:Exploratory Behavior / Q000187:drug effects; D005518:Food Preferences / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D012919:Social Behavior; D013649:Taste / Q000187:drug effects
chemical_list: D000578:Amidines; D002742:Chlorphenamidine