Fc-receptor function in Henoch-Schönlein disease of childhood.
The Fc-receptor function of circulating monocytes (CM) and/or of splenic macrophages (SM) was followed in eight children presenting with rheumatoid purpura. The Fc-receptor of CM and/or of SM was decreased in all cases during the acute phase of the disease without any correlation with the plasma values of C3, C4, C3PA or immune complexes. When a clinical improvement occurred, a reversal of the Fc-receptor blockade was noted. In contrast, the Fc-receptor function remained abnormal in three children with persistent nephritis. The sequential measurement of Fc-receptor function may be of predictive value in rheumatoid purpura of childhood.
D000936:Antigen-Antibody Complex / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D011415:Complement Factor B / Q000032:analysis; D005260:Female; D006801:Humans; D011695:IgA Vasculitis / Q000276:immunology*; D007223:Infant; D008264:Macrophages / Q000276:immunology; D008297:Male; D009000:Monocytes / Q000276:immunology; D011961:Receptors, Fc / Q000276:immunology*; D013154:Spleen / Q000166:cytology
D000936:Antigen-Antibody Complex; D003176:Complement C3; D003181:Complement C4; D011961:Receptors, Fc; D011415:Complement Factor B