title: The effect of chemical intravaginal contraceptives and Betadine on Ureaplasma urealyticum.
abstract: The purpose of this study was to find a barrier contraceptive agent capable of controlling infections and sexual transmission of Ureaplasma urealyticum from the female genital tract, especially to help reduce nongonococcal urethritis in males caused by this organism. Therefore, the in vitro antimicrobial activity of six intravaginal contraceptives and BetadineR against the eight serotypes of the organism was investigated. The results indicate that some of these contraceptives produce partial inhibition of the Ureaplasma at low dilutions, while BetadineR produces a ureaplasmacidal effect up to dilutions of 1:64. These effects appear not to be due primarily to the pH of these agents. Thus, some of these agents may have a potential role in controlling transmission of Ureaplasma urealyticum.
mesh_terms: D003271:Contraceptive Agents, Female / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D011205:Povidone / Q000031:analogs & derivatives*; D011206:Povidone-Iodine / Q000494:pharmacology*; D012749:Sexually Transmitted Diseases / Q000382:microbiology / Q000517:prevention & control*; D014509:Ureaplasma / Q000187:drug effects*; D014526:Urethritis / Q000382:microbiology / Q000517:prevention & control*; D014627:Vaginitis / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D003271:Contraceptive Agents, Female; D011206:Povidone-Iodine; D011205:Povidone