Differentiation of F9 teratocarcinoma stem cells after transfer of c-fos proto-oncogenes.
Transfer of mouse or human c-fos proto-oncogenes into F9 teratocarcinoma stem cells results in expression of c-fos mRNA and protein. This is accompanied by the appearance of morphologically altered cells which express several specific markers characteristic of differentiated cells, suggesting that c-fos plays a role in cellular differentiation.
D000818:Animals; D002454:Cell Differentiation; D003599:Cytoskeleton / Q000648:ultrastructure; D005109:Extracellular Matrix / Q000378:metabolism; D005786:Gene Expression Regulation; D051379:Mice; D009857:Oncogenes; D012333:RNA, Messenger / Q000235:genetics; D013724:Teratoma / Q000235:genetics / Q000473:pathology*; D014162:Transfection
D012333:RNA, Messenger