Bacterio-pharmacological activity of Saccharomyces boulardii in clindamycin-induced colitis in the hamster.
The effect of S. boulardii on experimental colitis induced by the single oral administration of 1 mg/kg of clindamycin in the Syrian hamster was studied. Oral administration of S. boulardii for 13 days, starting 3 days prior to the administration of clindamycin, significantly reduced the mortality rate and inhibited the growth of C. difficile in the caecum and colon. There was a marked improvement in the sub-mucosa and mucosa which showed major inflammatory lesions when clindamycin was administered alone.
D000818:Animals; D002981:Clindamycin; D003013:Clostridium / Q000187:drug effects; D006224:Cricetinae; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced / Q000382:microbiology*; D007413:Intestinal Mucosa / Q000382:microbiology; D008297:Male; D008647:Mesocricetus; D012440:Saccharomyces / Q000502:physiology*
D002981:Clindamycin