title: Regulation of neuropeptide Y (NPY) binding by guanine nucleotides in the rat cerebral cortex.
abstract: In the presence of GTP, GDP, GMPP(NH)P, GMPP(CH2)P, GMPP(S)P but not in the presence of GMP, cGMP or ATP, the high affinity binding of neuropeptide Y (NPY) was reduced in a dose-dependent manner. GTP (0.1 mM) diminished the maximal binding capacity for 125I-labelled NPY by 40% without any change in the equilibrium dissociation constant of the receptor 125I-labelled NPY complex.
mesh_terms: D000227:Adenine Nucleotides / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006150:Guanine Nucleotides / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009478:Neuropeptide Y; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000227:Adenine Nucleotides; D006150:Guanine Nucleotides; D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y