[Chronotherapy of breast cancer induced by N-nitrosomethylurea in the rat. I. Effect of a high dose of cyclophosphamide administered at 8:00 and 14:00 hours].
The administration of cyclophosphamide (200 mg/kg) intraperitoneally produces a high mortality in Wistar rats bearing mammary tumors induced by N-methylnitrosourea. The effect is more marked when the drug is administered at 8:00 A.M. than when given at 2:00 P.M. The injection of cyclophosphamide at 2:00 P.M. slowers the tumor growth, the effect being significative after two weeks compared with the control animals, and after four weeks when compared with the animals receiving the drug at 8:00 A.M.
D000818:Animals; D001711:Biotransformation; D002940:Circadian Rhythm; D003520:Cyclophosphamide / Q000008:administration & dosage* / Q000627:therapeutic use / Q000633:toxicity; D004334:Drug Administration Schedule; D005260:Female; D007274:Injections, Intraperitoneal; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D008770:Methylnitrosourea; D051381:Rats; D011919:Rats, Inbred Strains
D008770:Methylnitrosourea; D003520:Cyclophosphamide
Cronoterapia del cáncer de mama inducido con N-nitrosometilurea en la rata. I. Efecto de una dosis elevada de ciclofosfamida administrada a las 8.00 y 14.00 horas.