title: Neuromedin B is a major bombesin-like peptide in rat brain: regional distribution of neuromedin B and neuromedin C in rat brain, pituitary and spinal cord.
abstract: Neuromedin B and neuromedin C are the novel mammalian bombesin-like peptides isolated from porcine spinal cord. We have developed highly specific and sensitive radioimmunoassays for neuromedin B and neuromedin C, and determined their regional distribution in rat central nervous system. Prior to measurements of the tissue contents, immunoreactive neuromedin B and C were characterized by gel-filtration and high performance liquid chromatography. Neuromedin B and C immunoreactivities have similar regional distribution in rat brain, but the content of immunoreactive neuromedin B is 2-6 times higher than that of immunoreactive neuromedin C in every region. These results indicate that neuromedin B is a major endogenous bombesin-like peptide in rat brain and has specific functions of physiological importance.
mesh_terms: D000311:Adrenal Glands / Q000032:analysis; D000818:Animals; D001839:Bombesin / Q000032:analysis; D001923:Brain Chemistry; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D003429:Cross Reactions; D007106:Immune Sera; D008970:Molecular Weight; D015287:Neurokinin B / Q000031:analogs & derivatives*; D009842:Oligopeptides / Q000032:analysis*; D010446:Peptide Fragments; D010902:Pituitary Gland / Q000032:analysis*; D013116:Spinal Cord / Q000032:analysis*; D013552:Swine; D014018:Tissue Distribution
chemical_list: D007106:Immune Sera; D009842:Oligopeptides; D010446:Peptide Fragments; C040794:neuromedin C; D015287:Neurokinin B; C038393:neuromedin B; D001839:Bombesin