title: The effects of sucralfate ingestion on serum and specific tissue aluminum concentration in normal rats.
abstract: The effects of sucralfate ingestion on serum and specific tissue aluminum (Al) accumulation were studied in normal rats fed either a control diet or the same diet supplemented with sucralfate. Although serum Al concentrations were not significantly different between the groups, animals fed sucralfate for 8 weeks had significantly higher bone but not brain or liver Al concentrations when compared with controls. This study indicates that 8 weeks exposure to Al in sucralfate leads to an increase in bone Al concentrations, without changes in serum Al concentrations, suggesting that serum Al concentration may be a poor predictor of gastrointestinal absorption and specific tissue retention of Al.
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D000535:Aluminum / Q000032:analysis / Q000097:blood* / Q000378:metabolism* / Q000633:toxicity; D000818:Animals; D001806:Blood Urea Nitrogen; D002118:Calcium / Q000097:blood; D008297:Male; D010758:Phosphorus / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013392:Sucralfate; D014018:Tissue Distribution
chemical_list: D010758:Phosphorus; D013392:Sucralfate; D000535:Aluminum; D002118:Calcium