The influence of permanent adrenalin application on the triacylglycerol concentration and fatty acid synthesis in various tissues of the rat.
Adrenalin tablets (15 mg) or placebos were implanted into the neck of male Sprague-Dawley rats weighing between 150 to 250 g. 18 hours after implantation a significant lipolysis as well as enhanced concentrations of triacylglycerol in liver, kidney cortex and skeletal muscle can be observed in adrenalin treated rats. Measurements of fatty acid synthesis (3H method) in these tissues indicate that in kidney cortex and liver there is no contribution of local synthesis to elevated triacylglycerol content. In skeletal muscle local synthesis seems to be efficient to some degree. The main cause for lipid deposition in adrenalin supplied rats is, therefore, uptake of free fatty acids from the blood and following esterification with glycerol.
D000818:Animals; D004343:Drug Implants; D004837:Epinephrine / Q000494:pharmacology*; D005227:Fatty Acids / Q000096:biosynthesis*; D006321:Heart / Q000187:drug effects; D007672:Kidney Cortex / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000187:drug effects / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism*
D004343:Drug Implants; D005227:Fatty Acids; D014280:Triglycerides; D004837:Epinephrine