Pharmacokinetics of antimicrobial agents.
The use of formulas or nomograms is not a substitute for or in conflict with measurement of drug levels. We are always obligated to use the best available strategy in choosing a loading and maintenance dose. We must likewise measure and use serum levels for drugs with a narrow therapeutic margin, drugs administered for a long duration of time, and when there is uncertainty about a drug's kinetics. (The classic example is a patient on an aminoglycoside for more than three days, elderly or in renal failure).
D000368:Aged; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D001682:Biological Availability; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male
D000900:Anti-Bacterial Agents