Investigation of the effects of muscimol on different components of [3H]propyl beta-carboline-3-carboxylate binding to rat hippocampal and cerebellar membranes.
The binding of [3H]propyl beta-carboline-3-carboxylate [( 3H]PCC) to rat hippocampal and cerebellar membranes was investigated together with the displacement by PCC of [3H]flunitrazepam [( 3H]FNM). Results were consistent with the presence of a single recognition site in cerebellum and two sites in hippocampys, but the affinity of neither of the hippocampal sites correlated with that in the cerebellum. Muscimol did not alter the affinity or capacity of any of these sites under the conditions used, indicating that PCC does not show the benzodiazepine-like property of GABAergic modulation, at any of the subpopulations of its binding sites.
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002243:Carbolines / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D002531:Cerebellum / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D007211:Indoles / Q000378:metabolism*; D008297:Male; D009118:Muscimol / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D002243:Carbolines; D007211:Indoles; D010080:Oxazoles; D009118:Muscimol; C028585:propyl beta-carboline-3-carboxylate