Dihomo-gamma-linolenic acid reverses hypertension induced in rats by diets rich in saturated fat.
This study has shown that hypertension induced in rats by a diet rich in saturated fat (16% coconut oil, 4% palmitic acid by weight) is reversed by the addition of the essential fatty acid, dihomo-gamma-linolenic acid (DHLA), at 5.0% but not at 0.5% of dietary energy. This potent effect of DHLA has been attributed to modulation of prostaglandin biosynthesis.
D015126:8,11,14-Eicosatrienoic Acid / Q000494:pharmacology*; D000527:Alprostadil; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D006973:Hypertension / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D011458:Prostaglandins E / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D011458:Prostaglandins E; D000527:Alprostadil; D015126:8,11,14-Eicosatrienoic Acid