New antitumor antibiotic, LL-C10037 alpha. Fermentation, isolation and structure determination.
A new antitumor antibiotic, LL-C10037 alpha was isolated from the fermentation filtrate of a Streptomyces by adsorption, partition and reverse phase column chromatography. Its chemical structure was determined by 1H NMR, 13C NMR, UV, IR and mass spectral data. LL-C10037 alpha is a gamma-aminoepoxysemiquinone and is related to the epoxyguinone class of antibiotics.
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002621:Chemistry; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D011809:Quinones / Q000096:biosynthesis / Q000302:isolation & purification; D013302:Streptomyces / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D011809:Quinones; C043671:LL-C 10037alpha