title: [Substances contained in the coelomic fluid of Lumbricus terristris having functions in common with those of some human complement components].
abstract: In the present work, it was demonstrated for the first time that the coelomic fluid of Lumbricus terrestris contained a substance recognized by human classical convertase. This substance permitted an immune, complement-dependent agglutination response of sheep erythrocytes carrying C3-convertase (EAC142). In addition, substances secreted by coelomic leukocytes possessed an inhibitory activity against human complement: the component C3 was cleaved into a C3b fragment. This result suggests the presence of a system the function of which is C3-convertase-like. We have thus shown that some complement functions, with their natural inhibitors, appear early in evolution. Certain of these functions and structures might be preserved throughout evolution.
mesh_terms: D000818:Animals; D005075:Biological Evolution; D001826:Body Fluids / Q000032:analysis / Q000166:cytology / Q000276:immunology*; D050577:Complement C3-C5 Convertases / Q000276:immunology; D003179:Complement C3b / Q000032:analysis; D003169:Complement Inactivator Proteins / Q000502:physiology; D003165:Complement System Proteins / Q000276:immunology*; D006386:Hemagglutination Tests; D006801:Humans; D007962:Leukocytes / Q000276:immunology; D009835:Oligochaeta / Q000276:immunology*
chemical_list: D003169:Complement Inactivator Proteins; D003179:Complement C3b; D003165:Complement System Proteins; D050577:Complement C3-C5 Convertases
vernacular_title: Mise en évidence de substances contenues dans le liquide coelomique de Lumbricus terrestris, possédant des fonctions communes avec celles de certains composants du complément humain.