title: Synthesis of 3-C-(hydroxymethyl)erythritol and 3-C-methylerythritol.
abstract: 3-C-(Hydroxymethyl)erythritol was prepared from 3-C-(hydroxymethyl)-2,3-O-isopropylidene-D-erythro-tetrofuranose (4) by hydrolysis followed by reduction, or by reduction followed by hydrolysis. Monotosylation of 4, followed by reduction with lithium aluminum hydride and hydrolysis, afforded 3-C-methylerythritol.
mesh_terms: D004896:Erythritol / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D006863:Hydrogen-Ion Concentration; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009904:Optical Rotation
chemical_list: D007202:Indicators and Reagents; C043903:3-(hydroxymethyl)erythritol; C043904:3-C-methylerythritol; D004896:Erythritol