title: [Endocrine and metabolic mechanisms of the pathological syndrome due to antigens of homologous glial tissue in monkeys].
abstract: Monkeys (Macaca mulatta) of both sexes repeatedly immunized with a complex of glial antigens of the homologous brain demonstrated abnormalities of hormonal functions after 1 to 5 weeks. These abnormalities were marked by a decrease in the total serum tyroxine (after 1 week) and a rise in the concentration of 11-hydroxycorticosteroids (11-OHCS) that occurred after 5 weeks. The changes in tyroxine level were more stable than those in the concentration of 11-OHCS. The immunized animals manifested changes in the disc electrophoregram of the serum. Application of stress resulted in a consistent elevation of the concentration of 11-OHCS and in temporary changes in the number and intensity of individual fractions of serum proteins. The fractional composition of serum proteins was different in control and experimental monkeys.
mesh_terms: D015062:11-Hydroxycorticosteroids / Q000097:blood; D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D002493:Central Nervous System Diseases / Q000209:etiology* / Q000276:immunology; D005260:Female; D006801:Humans; D007114:Immunization / Q000379:methods; D008253:Macaca mulatta; D008297:Male; D009457:Neuroglia / Q000276:immunology*; D013315:Stress, Psychological / Q000276:immunology; D013577:Syndrome; D013963:Thyroid Hormones / Q000097:blood; D013997:Time Factors
chemical_list: D015062:11-Hydroxycorticosteroids; D000941:Antigens; D013963:Thyroid Hormones
vernacular_title: Endokrinnye i metabolicheskie mekhanizmy patologicheskogo sindroma, vyzvannogo antigenami gomologichnoĭ glial'noĭ tkani u obez'ian.