title: [Genetic analysis of the susceptibility to neurological manifestations in spinal osteochondrosis].
abstract: Complex genetic-mathematical analysis (component decomposition of the phenotype variance, segregation analysis, estimation of penetrance parameters) of 324 probands' families with neurologic manifestation of spinal osteochondrosis (3437 relatives of I-III degree) has been carried out is shown that the structure of liability to the disease studied is better approximated by semi-continuous phenotype model within the limits of which contribution of genetic factors reaches 80% (63-66% owing to autosomes and 14-17% owing to gonosomes) under considerable influence (20%) of environmental force (14% accidental and 6% systematic).
mesh_terms: D000367:Age Factors; D004198:Disease Susceptibility; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D006801:Humans; D008297:Male; D009422:Nervous System Diseases / Q000235:genetics*; D010007:Osteochondritis / Q000235:genetics*; D010641:Phenotype; D012727:Sex Characteristics; D013122:Spinal Diseases / Q000235:genetics*
vernacular_title: Geneticheskiĭ analiz podverzhennosti nevrologicheskim proiavleniiam osteokhondroza pozvonochnika.