title: Cardiovascular effects in the rat of intrathecal injections of apomorphine at the thoracic spinal cord level.
abstract: Intrathecal (i.t.) administration of apomorphine at the upper thoracic level lowered blood pressure and heart rate in awake rats. This decrease was dose-dependent and competitively antagonized by haloperidol (i.v. and i.t.) or domperidone (i.t.) but not by domperidone (i.v.). Furthermore, these effects of apomorphine were not affected by alpha- and beta-blocking drugs (i.t.). The results suggest a spinal site, at least in part, for the cardiovascular effect of apomorphine.
mesh_terms: D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D004294:Domperidone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects*; D007278:Injections, Spinal; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects*
chemical_list: D011954:Receptors, Dopamine; D004294:Domperidone; D006220:Haloperidol; D001058:Apomorphine