Depressed lectin-dependent cell-mediated cytotoxicity against adherent HEP-2 cells in patients with carcinoma of the uterine cervix.
Lectin-dependent cell-mediated cytotoxicity of peripheral blood mononuclear cells from patients with uterine cervix carcinoma was evaluated using human adherent 3H-TdR-prelabeled HEp-2 epipharynx carcinoma cells as targets at a 50:1 effector-target cell ratio with 25 micrograms concanavalin A/ml in a 24-h assay. Peripheral blood mononuclear cells from 13 patients with cervical carcinoma in stage IV failed to exert cytotoxicity against HEp-2 targets. In contrast, an increased survival (decreased detachment from the monolayer) of HEp-2 cells was observed in the presence of peripheral blood mononuclear cells from patients, this being significantly enhanced by addition of concanavalin A during the lectin-dependent cell-mediated cytotoxicity assay.
D000920:Antibody-Dependent Cell Cytotoxicity; D002294:Carcinoma, Squamous Cell / Q000276:immunology; D002448:Cell Adhesion; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D004261:DNA Replication; D005260:Female; D006801:Humans; D037102:Lectins; D009504:Neutrophils / Q000276:immunology; D010610:Pharyngeal Neoplasms / Q000276:immunology*; D002583:Uterine Cervical Neoplasms / Q000276:immunology*
D037102:Lectins