[Effect of spirobramin and prospidin on immunogenesis].
The immunosuppressant effects of the antineoplastic piperazine drugs spirobramine and prospidin in respective doses of 500 and 600 mg/kg (1/2 of the LD50) were studied in experiments on cats. Spirobramine was shown to exert a more pronounced immunoinhibitory action on the primary and secondary immune response induced by sheep red blood cells.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D007108:Immune Tolerance / Q000187:drug effects; D007114:Immunization; D007117:Immunization, Secondary; D051379:Mice; D008807:Mice, Inbred BALB C; D009930:Organic Chemicals; D010879:Piperazines / Q000494:pharmacology*; D011447:Prospidium / Q000494:pharmacology*; D012397:Rosette Formation; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D000970:Antineoplastic Agents; D009930:Organic Chemicals; D010879:Piperazines; D011447:Prospidium; C038297:spirobramin
Vliianie spirobramina i prospidina na immunogenez.