Treatment of autochthonous rat colonic adenocarcinomas with a thioether-lysophospholipid derivative in mono- and combination chemotherapy.
In 361 Sprague-Dawley rats autochthonous colorectal carcinomas were induced by intrarectal application of the carcinogen AMMN. Tumor-bearing animals were treated with a synthetic thioether-lysophospholipid (TLP) derivative and in combination chemotherapy with 5-fluorouracil (5-FU) and carmustine (BCNU). There was no difference in the survival time of treated and untreated animals. The median large-bowel tumor weight was significantly lower in the TLP/5-FU and TLP/5-FU/BCNU combination therapy groups than in the control groups. Transient hepatotoxicity was observed in the high-dosage (50 mg/kg body weight twice weekly) TLP group. This study confirmed the relative resistance of AMMN-induced colorectal carcinomas to antineoplastic treatment.
D000230:Adenocarcinoma / Q000139:chemically induced / Q000188:drug therapy*; D000284:Administration, Oral; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols; D002273:Carcinogens; D002330:Carmustine / Q000008:administration & dosage; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives; D004334:Drug Administration Schedule; D005472:Fluorouracil / Q000008:administration & dosage; D007274:Injections, Intraperitoneal; D007422:Intestines / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010755:Organophosphates / Q000008:administration & dosage / Q000627:therapeutic use*; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D010742:Phospholipid Ethers; D051381:Rats; D011919:Rats, Inbred Strains
D000970:Antineoplastic Agents; D002273:Carcinogens; D010755:Organophosphates; D009943:Organophosphorus Compounds; D010742:Phospholipid Ethers; C014659:methyl(acetoxymethyl)nitrosamine; C043297:ilmofosine; D004128:Dimethylnitrosamine; D005472:Fluorouracil; D002330:Carmustine