A spirohydantoin derivative of dimethoxytetrahydronaphthalene: an experimental anticonvulsant.
A 2-spirohydantoin of 6,7-dimethoxytetrahydronaphthalene was synthesized and purified. The compound, showing structural similarities to both phenytoin and dopamine, was found to decrease spontaneous motor activity of mice and to exert a pronounced protective effect against convulsive seizures induced by pentylenetetrazol (Metrazol).
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D004597:Electroshock; D005106:Exploratory Behavior / Q000187:drug effects*; D006827:Hydantoins / Q000138:chemical synthesis / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D010433:Pentylenetetrazole / Q000633:toxicity; D012640:Seizures / Q000503:physiopathology
D000927:Anticonvulsants; D006827:Hydantoins; C042025:2-spirohydantoin-6,7-dimethoxytetrahydronaphthalene; D010433:Pentylenetetrazole