Enhancement by phenothiazine and 2,5-di-O-acetyl-D-glucosaccharo-(1,4)(6,3)-dilactone of bladder carcinogenicity of N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide in rats.
Rats concomitantly fed N-[4-(5-nitro-2-furyl)-2-thiazolyl] formamide (FANFT) and phenothiazine, or concomitantly fed FANFT and Glucaron then fed Glucaron alone had significantly greater incidences of transitional cell carcinomas of the bladder than rats fed FANFT alone. Caffeine and cysteamine did not affect FANFT bladder carcinogenesis. Phenothiazine induced nitroreductase activity of hepatic microsomes.
D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002273:Carcinogens / Q000378:metabolism; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced*; D003043:Cocarcinogenesis; D005200:FANFT / Q000378:metabolism / Q000633:toxicity*; D005260:Female; D005937:Glucaric Acid / Q000031:analogs & derivatives / Q000633:toxicity*; D005966:Glucuronidase / Q000037:antagonists & inhibitors*; D009601:Nitroreductases; D010088:Oxidoreductases / Q000032:analysis; D010640:Phenothiazines / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D013400:Sugar Acids / Q000633:toxicity*; D013844:Thiazoles / Q000633:toxicity*; D001743:Urinary Bladder / Q000473:pathology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
D002273:Carcinogens; D010640:Phenothiazines; D013400:Sugar Acids; D013844:Thiazoles; C038936:aceglatone; D002110:Caffeine; D005200:FANFT; D010088:Oxidoreductases; D009601:Nitroreductases; D005966:Glucuronidase; C031637:phenothiazine; D005937:Glucaric Acid