Antagonism of apomorphine-induced cage climbing behaviour and methamphetamine stereotypy by fenfluramine in mice.
Pretreatment with fenfluramine (5 and 10 mg/kg, ip) in doses which induced head twitches was found to antagonize apomorphine-induced cage climbing behaviour and methamphetamine stereotypy in mice. Since fenfluramine (5 and 10 mg/kg) did not induce catalepsy it indicates that fenfluramine lacks postsynaptic striatal and mesolimbic dopamine receptor blocking activity and it is possible that the fenfluramine-induced enhancement of central 5-hydroxytryptamine neuronal transmission may be responsible for its antagonistic effect on apomorphine-induced climbing behaviour and methamphetamine stereotypy.
D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors*; D002375:Catalepsy / Q000139:chemically induced; D005277:Fenfluramine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors*; D051379:Mice; D013239:Stereotyped Behavior / Q000187:drug effects*
D005277:Fenfluramine; D008694:Methamphetamine; D001058:Apomorphine