[Treatment of fertility disturbances in the male with a combination of mesterolone and kallikrein].
73 males with different fertility disturbances (53 X oligozoospermia, 4 X asthenozoospermia and 16 X teratozoospermia) were treated by a combination of mesterolone (50 mg daily) and kallikrein (6 X 100 KU daily; every two hours one tablet); duration of treatment: three months. Before starting the treatment two semen analyses were performed; furthermore semen control at the end of the treatment as well as three and six months after ending the therapy. The sperm density don't demonstrate any changes. The normal morphology of the spermatozoa increased about 10%. In selected cases with a very bad sperm morphology a testicular biopsy were performed; in these cases the percentage of normal spermatozoa increased for about 21%. The motility rate showed no significant changes. It can be demonstrated that this combination don't better effects than other treatment. The best way is a treatment at a well selected material with a special drug for a special case.
D000328:Adult; D013196:Dihydrotestosterone / Q000031:analogs & derivatives*; D004359:Drug Therapy, Combination; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy*; D007610:Kallikreins / Q000627:therapeutic use*; D008297:Male; D008655:Mesterolone / Q000627:therapeutic use*; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects
D013196:Dihydrotestosterone; D008655:Mesterolone; D007610:Kallikreins
Zur Behandlung von Fertilitätsstörungen des Mannes mit einer Kombination von Mesterolon und Kallikrein.