title: Drug combinations--concepts and terminology.
abstract: The terms "synergism" and "antagonism" are used inconsistently in pharmacology and toxicology designating different circumstances. This is a source of recurring scientific conflict. The present paper elucidates the existing discrepancies, and offers a consistent terminology incorporating also such terms as "additivity", "potentiation", and "simple similarity".
mesh_terms: D002626:Chemistry, Pharmaceutical; D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D004338:Drug Combinations; D004357:Drug Synergism; D008954:Models, Biological
chemical_list: D004338:Drug Combinations