Effects of 5-thio-D-glucose and 2-deoxy-D-glucose upon stomach-emptying in the golden hamster.
5-Thio-D-glucose (200 and 500 mg/kg) produced hyperglycemia and significantly retarded emptying of the pregastric pouch of hamsters. 2-Deoxy-D-glucose did not affect stomach-emptying at either of the doses used (500 and 1000 mg/kg), but did cause hyperglycemia at the higher dose. These results are discussed in relation to the failure of these glucose analogs to produce hyperphagia in the golden hamster.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D006224:Cricetinae; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D005247:Feeding Behavior / Q000187:drug effects; D005746:Gastric Emptying / Q000187:drug effects*; D005947:Glucose / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008647:Mesocricetus
D001786:Blood Glucose; D003837:Deoxy Sugars; C003002:5-thio-D-glucose; D003847:Deoxyglucose; D005947:Glucose