[Effect of fractionated irradiation of tumor-bearing animals on their survival].
The authors investigated a possibility to use murine lymphosarcoma LS/BL for a study of the efficacy of fractional irradiation of tumor-bearing animals. Apart from the normal LS/BL cell line, LS/BL-CI cell line was used which was constantly irradiated at a low dose rate (5 P/hour). The therapeutic effect of fractional irradiation manifested itself in case of LS/BL only, whereas in case of constantly irradiated cells the result of irradiation and growth of tumor cells, on the contrary, summarized. It was determined that both lines have approximately the same D0 value and that no changes in the ability of the reparation of lethal injuries were observed in the chronically irradiated LS/BL cell line. Using a method of colony formation in the liver a significant ability of the reparation of a sublethal injury was shown in case of a constantly irradiated population.
D000818:Animals; D008228:Lymphoma, Non-Hodgkin / Q000401:mortality / Q000532:radiotherapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D011879:Radiotherapy Dosage
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