title: A calculator program for least-squares parameter estimation according to the one-compartment kinetic model with zero-order input.
abstract: A calculator program that performs a nonlinear least-squares fit to data conforming to the one-compartment model with zero-order input is described. The program, which is designed for the Hewlett-Packard HP-41 CV calculator, is based on the Gauss-Newton iterative algorithm as modified by Hartley. A subroutine for calculation of initial parameter estimates is incorporated into the program. Plasma concentration data relative to a single oral dose of a sustained-release theophylline formulation are used to demonstrate the practical application of the program.
mesh_terms: D003201:Computers; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010600:Pharmacology; D012984:Software
chemical_list: D004364:Pharmaceutical Preparations