The kinetics of blood coagulability: fibrinolytic and kallikrein-kinin system at the onset and during labor.
The relationship between the kallikrein-kinin system, the coagulation system, and the fibrinolytic system was evaluated on 58 patients during pregnancy, labor and puerperium. Also included in this study were 7 patients with premature placental separation. The most prominent changes were those in the kallikrein-kinin system. After the onset of labor, prekallikrein decreases rapidly which may trigger changes in the blood coagulation and fibrinolytic system. The three systems have a close interrelationship possibly affecting uterine contractility during labor and delivery.
D000328:Adult; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000096:biosynthesis; D004211:Disseminated Intravascular Coagulation / Q000503:physiopathology*; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D007610:Kallikreins / Q000502:physiology; D007700:Kinetics; D007704:Kininogens / Q000096:biosynthesis; D007705:Kinins / Q000502:physiology; D007743:Labor, Obstetric; D010974:Platelet Aggregation; D049590:Postpartum Period; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000503:physiopathology*; D011288:Prekallikrein / Q000096:biosynthesis
D001779:Blood Coagulation Factors; D007704:Kininogens; D007705:Kinins; D011288:Prekallikrein; D007610:Kallikreins