Different oestrogenic responses of ICR, B6D2F1 and B6C3F1 mice given diethylstilboestrol orally.
Immature female ICR, B6D2F1 and B6C3F1 mice were each given a total of 0.1 microgram diethylstilboestrol (DES) by stomach intubation over 4 days. Using uterine weight as a measure of oestrogenic response, it was found that the two inbred strains were significantly more sensitive than the ICR mice to DES.
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004054:Diethylstilbestrol / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D013045:Species Specificity; D014599:Uterus / Q000187:drug effects*
D004054:Diethylstilbestrol