[Relation between the toxicity of molecules of industrial value and their physico-chemical properties: test of upper airway irritation applied to 4 chemical groups].
Correlations between molecular structure and a given biological activity have not, as yet, been widely applied to industrial toxicology. After a brief outline of the chief characteristics of the Hansch model and a definition of the selected physico-chemical parameters, this paper presents a study of the quantitative relationship between these parameters and upper-respiratory-tract irritation (determination of the RD50) for four chemical groups: ketones, alcohols, acetates and benzene derivatives.
D000085:Acetates / Q000633:toxicity*; D000438:Alcohols / Q000633:toxicity*; D000818:Animals; D001555:Benzene Derivatives / Q000633:toxicity*; D007509:Irritants; D007659:Ketones / Q000633:toxicity*; D008433:Mathematics; D051379:Mice; D012137:Respiratory System / Q000187:drug effects*; D013329:Structure-Activity Relationship
D000085:Acetates; D000438:Alcohols; D001555:Benzene Derivatives; D007509:Irritants; D007659:Ketones
Recherche de relations entre toxicité de molécules d'intérêt industriel et propriétés physico-chimiques: test d'irritation des voies aériennes supérieures appliqué à quatre familles chimiques.