title: A-16686, a new antibiotic from Actinoplanes. I. Fermentation, isolation and preliminary physico-chemical characteristics.
abstract: Actinoplanes sp. ATCC 33076 is a new strain that was found to produce an antibiotic, designated A-16686, which is a complex of three closely-related polypeptides containing chlorinated phenyl moieties and D-mannose. Both the complex and the single fractions possess a good activity against Gram-positive bacteria. A-16686 specifically inhibits the synthesis of the bacterial cell wall.
mesh_terms: D000192:Actinomycetales / Q000145:classification / Q000254:growth & development*; D000596:Amino Acids / Q000032:analysis; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002621:Chemistry; D003470:Culture Media; D047630:Depsipeptides; D004353:Drug Evaluation, Preclinical; D005285:Fermentation; D006020:Glycopeptides / Q000302:isolation & purification / Q000633:toxicity; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010456:Peptides, Cyclic
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D003470:Culture Media; D047630:Depsipeptides; D006020:Glycopeptides; D010456:Peptides, Cyclic; C041438:ramoplanin