[Changes in the cytochrome P-450 content of the liver of congenic resistant mouse strains during chronic alcoholization].
Differences were found in the levels of alcohol consumption in two pairs of congenic resistant mice (BI0.RI07, BI0.RIII and A/Sn, A.SW). BI0.RI07 and A/Sn mice were characterized as "drinking" compared to their congenic resistant partners BI0.R and A.SW. The concentration of cytochrome P-450 in the animal liver was measured at different periods of alcoholization. Certain correlation was found between the time-course of hemoprotein changes and the levels of alcohol consumption. The contribution of the major histocompatibility mouse system (H-2) to the correlations found is discussed.
D000428:Alcohol Drinking; D000437:Alcoholism / Q000201:enzymology*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D008099:Liver / Q000032:analysis / Q000201:enzymology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000378:metabolism*; D013053:Spectrophotometry; D013997:Time Factors
D003577:Cytochrome P-450 Enzyme System
Izmenenie soderzhaniia tsitokhroma P-450 v pecheni mysheĭ kongennykh rezistentnykh liniĭ v protsesse khronicheskoĭ alkogolizatsii.