Hemopoietic development in human embryos.
We report studies on hemopoietic progenitors and precursors in human embryos and fetuses at 4 to 5 through to 9 to 10 weeks from conception, as well as the corresponding in vivo Hb synthesis pattern. Particular attention is paid to the morphology of 5- to 8-week liver cells, as evaluated by both conventional and electron microscopy. On the basis of these observations, a unifying monoclonal model is proposed for human embryonic hemopoiesis.
D002478:Cells, Cultured; D004622:Embryo, Mammalian / Q000502:physiology*; D004900:Erythroblasts / Q000166:cytology / Q000648:ultrastructure; D005260:Female; D005333:Fetus / Q000502:physiology*; D005865:Gestational Age; D005914:Globins / Q000096:biosynthesis; D006410:Hematopoiesis; D006454:Hemoglobins / Q000096:biosynthesis; D006801:Humans; D008099:Liver / Q000196:embryology / Q000648:ultrastructure; D008854:Microscopy, Electron; D010587:Phagocytosis; D011247:Pregnancy
D006454:Hemoglobins; D005914:Globins