Isolation, chemical structure, acute toxicity, and some physicochemical properties of territrem C from Aspergillus terreus.
Territrem C, a new tremorgenic mycotoxin (C28H32O9; molecular weight, 512.20) was isolated from the chloroform extract of rice cultures of Aspergillus terreus 23-1, which also produces territrems A and B. Isolation, acute toxicity, and some physicochemical properties of territrem C are discussed in this paper. The spectral and chemical evidence indicated that the structural difference between territrem C and territrem B (C29H34O9) was in their phenyl moieties: a 4-hydroxy-3,5-dimethoxy phenyl group in territrem C and a 3,4,5-trimethoxy phenyl group in territrem B. It was also demonstrated that territrem B was obtained by methylation of territrem C with dimethyl sulfate.
D000818:Animals; D001230:Aspergillus / Q000032:analysis* / Q000472:pathogenicity; D005260:Female; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011714:Pyrans / Q000302:isolation & purification* / Q000633:toxicity
D011714:Pyrans; C040404:territrem A; C040405:territrem B; C040403:territrem C