Effects on the development of offspring of female mice exposed to platinum sulfate or sodium hexachloroplatinate during pregnancy or lactation.
On d 7 or 12 of gestation or on d 2 postpartum, Swiss ICR dams were administered either (1) a single intragastric dose of Pt(SO4) at the LD1 level or dilute H2SO4 at an equivalent volume, pH, and sulfate content, or (2) a single subcutaneous dose of Na2PtCl6 or phosphate-buffered saline at an equivalent volume and pH. To differentiate prenatal from postnatal effects of the compounds on the offspring, a full cross-fostering design was employed. Rate of growth (as a function of weight gain) and gross activity of the neonates were assessed on d 8 or 13 postpartum. On d 60-65 postpartum, open-field behavior (ambulations and rearings), rotarod performance, and passive avoidance learning of the adult offspring were investigated. Exposure to Pt(SO4)2 resulted in reduced offspring weight from d 8 to 45 postpartum, whereas the major effect of Na2PtCl6 was a reduction in activity level of the offspring of mothers exposed on d 12 of gestation.
D000704:Analysis of Variance; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D002945:Cisplatin / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D005333:Fetus / Q000187:drug effects*; D007774:Lactation; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010984:Platinum / Q000633:toxicity*; D011247:Pregnancy
D010984:Platinum; D002945:Cisplatin; C038762:disodium hexachloroplatinate