Testicular changes in the rat by prepuberal administration of a synthetic antiandrogen.
The testes of treated animals showed mature spermatozoa and a smaller surface of tubules. Spermatic wave shifted, showing more mitotic figures and less mature spermatozoa. Antiandrogen plus testosterone propionate (TP) and human chorionic gonadotropin (hCG) administration showed, respectively, increased and decreased prostate and testicular weights. Histological aspects of the tubules did not improve by hormonal replacement; instead, altered and multinucleated cells appeared. Testicular modifications showed that antiandrogen administration induced changes in gonadotropin secretion.
D000726:Androgen Antagonists / Q000494:pharmacology*; D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D006062:Gonadotropins / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011245:Pregnadienes / Q000494:pharmacology*; D011467:Prostate / Q000187:drug effects; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects; D012671:Seminiferous Tubules / Q000187:drug effects; D012741:Sexual Maturation; D013737:Testis / Q000187:drug effects* / Q000648:ultrastructure; D013739:Testosterone / Q000378:metabolism
D000726:Androgen Antagonists; D006063:Chorionic Gonadotropin; D006062:Gonadotropins; D011245:Pregnadienes; D013739:Testosterone; C045419:oxyma