[Polarographic determination of noxiptilin hydrochloride in tablets].
A direct current polarographic method is proposed for the determination of noxiptiline hydrochloride (1) in tablets. Electrochemical reduction of 1 in HCl (0.1 mol X 1(-1) yields by a 4e process a product identified as 10, 11-dihydro-5H-dibenzo[a,d]cyclohepten-5-amine. The relative standard deviation of the determination is 0.66% within the 10(-4) mol X 1(-1) range. The limit of detection is about 5 X 10(-6) mol X 1(-1). Individual tablet contents varied between 95.6 and 104.7%, conforming to the requirements of the monograph "Content Uniformity" U.S.P. XX.
D003986:Dibenzocycloheptenes / Q000032:analysis*; D006863:Hydrogen-Ion Concentration; D013058:Mass Spectrometry; D011048:Polarography / Q000379:methods; D013055:Spectrophotometry, Infrared; D013607:Tablets / Q000032:analysis
D003986:Dibenzocycloheptenes; D013607:Tablets; C100240:noxiptilin
Polarografische Gehaltsbestimmung von Noxiptilinhydrochlorid in Tabletten.