Carcinogenic effects of 3-di(hydroxymethyl)-amino-6-(5-nitro-2-furylethenyl)-1,2,4-triazine in the small intestine of Ishibashi and Wistar rats.
The carcinogenic effect of an oral administration of 3-di(hydroxymethyl)-amino-6-(5-nitro-2-furylethenyl)-1,2,4-triazin e (DHNT) was studied in two strains of rats. Ishibashi (IS) rats have a perpetual absorption disturbance while Wistar Imamichi (WI) rats have no such disturbance. Small intestinal carcinomas developed in 10 out of 15 (66.7%) IS rats and in all 8 (100%) Wistar rats given 3,500 ppm DHNT for 43 weeks. The total number of lesions in the small intestine was 24 in IS rats and 21 in WI rats. Histologically, the lesions consisted of 7 mucosal dysplasias, 4 adenomas and 12 tubular and 1 papillary adenocarcinoma in IS rats, and 3 mucosal dysplasias, 1 adenomas, and 15 tubular and 2 papillary adenocarcinomas in WI rats. The levels of plasma leucine aminopeptidase, copper and total protein were lower, while blood urea nitrogen was higher in both strains of rats given DHNT than in control rats.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D000236:Adenoma / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D000818:Animals; D007414:Intestinal Neoplasms / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D007421:Intestine, Small / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D014227:Triazines / Q000494:pharmacology*
D014227:Triazines; C015821:dihydroxymethylfuratrizine