Influence of environmental conditions on exocrine pancreatic response to intravenous injection of ethanol or 2-deoxyglucose in the dog.
When dogs have free access to the outside, an intravenous injection of ethanol depresses secretin-stimulated exocrine pancreatic secretion by a vagally mediated mechanism. This was shown in two separate series of six and seven dogs each. When dogs were kept in air-conditioned windowless kennels, the response to a meal was unchanged but the response to ethanol was reversed to stimulation. In four dogs, ethanol 1 g/kg was given during a secretin infusion. Three months after changing from open to closed kennels the inhibition (-86% for protein output) was still present, but after 6 months ethanol produced a stimulation (+62%) of pancreatic secretion. This increase was abolished, but not reversed, by keeping the animals outside during the day for four weeks, whereas after three months there was a partial restoration of the inhibitory effect (-39%). In contrast, changing from an open to a closed kennel changed the initial response to 2-deoxy-D-glucose (2-DG), 100 mg/kg, from stimulation to inhibition. These results suggest that environmental conditions affect the cranial regulation of pancreatic secretion.
D000818:Animals; D003837:Deoxy Sugars / Q000008:administration & dosage*; D003847:Deoxyglucose / Q000008:administration & dosage*; D004285:Dogs; D004777:Environment; D000431:Ethanol / Q000008:administration & dosage* / Q000494:pharmacology; D007275:Injections, Intravenous; D010179:Pancreas / Q000187:drug effects*; D010194:Pancreatin / Q000096:biosynthesis; D013472:Sunlight; D013696:Temperature
D003837:Deoxy Sugars; D000431:Ethanol; D010194:Pancreatin; D003847:Deoxyglucose