Absence of a requirement for long-range DNA torsional strain in the production of protein-associated DNA strand breaks in isolated mammalian cell nuclei by the DNA intercalating agent 4'-(9-acridinylamino)methanesulfon-m-anisidide (m-AMSA).
D000609:Aminoacridines / Q000494:pharmacology*; D000677:Amsacrine; D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism*; D004273:DNA, Neoplasm / Q000378:metabolism* / Q000528:radiation effects; D003852:Deoxyribonucleoproteins / Q000378:metabolism*; D004307:Dose-Response Relationship, Radiation; D007364:Intercalating Agents / Q000494:pharmacology*; D007700:Kinetics; D007939:Leukemia L1210 / Q000378:metabolism; D051379:Mice
D000609:Aminoacridines; D004273:DNA, Neoplasm; D003852:Deoxyribonucleoproteins; D007364:Intercalating Agents; D000677:Amsacrine