[Peroral kallikrein therapy for male infertility--comparison between smokers and non-smokers].
101 male patients with idiopathic Oligo-, Astheno- and Oligoasthenozoospermia were given Kallikrein orally (3 X 200 KE daily) for 100 days. Sperm controls were performed before, during and after treatment. The evaluation of the results of the patient group showed, that sperm density, total sperm count, qualitative and quantitative motility during and after therapy had improved significantly. The patients were divided into 4 groups: smoker, non-smoker, group I and group II. Patients in group I had a sperm density equal to or less than 20 X 10(6) sperm/ml; those in group II had a sperm density greater than 20 X 10(6) sperm/ml. This calculation was determined by the average of two sperm controls before treatment. A significant improvement was practically seen only in the groups of smokers. The possible reasons are discussed.
D000284:Administration, Oral; D000328:Adult; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy*; D007610:Kallikreins / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D012907:Smoking; D013076:Sperm Count; D013081:Sperm Motility
D007610:Kallikreins
Perorale Kallikrein-Therapie bei männlicher Infertilität--Unterschiede zwischen Rauchern und Nichtrauchern.