title: Effects of 1,25-dihydroxycholecalciferol on fracture healing. Calcium, phosphate, and zinc in callus and serum.
abstract: The incorporation of calcium, phosphate, and zinc into the callus of closed tibial fractures was studied in adult rats fed a standard diet. Low doses (60 ng/kg per day) of 1,25(OH)2D3 5 days a week greatly increased early callus mineralization. This was not related to an increased serum calcium-phosphate molar product but rather to a decreased ratio. The incorporation of zinc into callus seemed to be correlated to the mineralization process but not to the 1,25(OH)2D3 administration as such. The question of a direct, indirect, or a complex role of 1,25(OH)2D3 in bone formation and mineralization is discussed.
mesh_terms: D000818:Animals; D001835:Body Weight; D002146:Bony Callus / Q000378:metabolism*; D002117:Calcitriol / Q000494:pharmacology*; D002118:Calcium / Q000032:analysis; D010710:Phosphates / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D013978:Tibial Fractures / Q000503:physiopathology*; D014945:Wound Healing / Q000187:drug effects*; D015032:Zinc / Q000032:analysis
chemical_list: D010710:Phosphates; D002117:Calcitriol; D015032:Zinc; D002118:Calcium