[Several peculiarities of hexokinase of malignant and benign tumors in man].
The total activity and isoenzyme spectrum of hexokinase (HK) were investigated in normal tissues as well as malignant and benign tumours of man. Electrophoresis in agar gel has revealed that the normal tissues are usually characterized by HK-I. In malignant tumours HK-II and additional anode fractions of KH-II and HK-III were observed. The HK isoenzyme spectrum in the benign tumours was similar to those of homologous normal tissues. The values of the HK-II/HK-I ratio were higher in the malignant tumours as compared with the benign tumours and normal tissues. These results may be used for diagnosis. Changes in the isoenzyme spectrum do not depend on histological structure of tumours, are secondary and depend on tumour progression.
D001943:Breast Neoplasms / Q000201:enzymology; D004587:Electrophoresis, Agar Gel; D004938:Esophageal Neoplasms / Q000201:enzymology; D005260:Female; D006593:Hexokinase / Q000032:analysis*; D006801:Humans; D007527:Isoenzymes / Q000032:analysis*; D008175:Lung Neoplasms / Q000201:enzymology; D009369:Neoplasms / Q000201:enzymology*; D010051:Ovarian Neoplasms / Q000201:enzymology; D013274:Stomach Neoplasms / Q000201:enzymology; D014594:Uterine Neoplasms / Q000201:enzymology
D007527:Isoenzymes; D006593:Hexokinase
Nekotorye osobennosti geksokinazy zlokachestvennykh i dobrokachestvennykh opukholeĭ cheloveka.