title: Preliminary pharmacokinetics of intravenous ciramadol in humans.
abstract: Plasma concentrations of ciramadol were measured after intravenous administration of 30 mg in 8 healthy volunteers. A high-performance liquid chromatographic method with U.V.-detection for simultaneous determination of the substance and of its desmethyl metabolite was developed. The disposition of the drug in these volunteers could be described by a two-compartment open model. Distribution volume was on average 561, elimination half-life 3.85 hours and mean body clearance 154 ml/min. Desmethylciramadol was not detected in the plasma.
mesh_terms: D000328:Adult; D000588:Amines / Q000378:metabolism*; D000700:Analgesics / Q000008:administration & dosage / Q000097:blood*; D001596:Benzylamines / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male
chemical_list: D000588:Amines; D000700:Analgesics; D001596:Benzylamines; C018273:ciramadol