The effects of the beta-carboline FG 7142, on intracranial self-stimulation in the rat.
The effects of FG 7142 were examined, alone and in combination with chlordiazepoxide, on self-stimulation of the mid-lateral hypothalamus. Rewarding stimuli were delivered according to a 10-sec variable-interval schedule of reinforcement. FG 7142 (1-20 mg/kg) produced a dose-related depression in responding, and chlordiazepoxide (5 mg/kg) enhanced it. When these two drugs were given together, response rates did not differ significantly from control rates.
D000818:Animals; D002243:Carbolines / Q000494:pharmacology*; D002707:Chlordiazepoxide / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012653:Self Stimulation / Q000187:drug effects*; D013997:Time Factors
D002243:Carbolines; D007211:Indoles; C035874:FG 7142; D002707:Chlordiazepoxide