The three-dimensional structure of retinol-binding protein.
The complex of retinol with its carrier protein, retinol-binding protein (RBP) has been crystallized and its three-dimensional structure determined using X-ray crystallography. Its most striking feature is an eight-stranded up-and-down beta barrel core that completely encapsulates the retinol molecule. The retinol molecule lies along the axis of the barrel with the beta-ionone ring innermost and the tip of the isoprene tail close to the surface.
D000818:Animals; D001665:Binding Sites; D006801:Humans; D008958:Models, Molecular; D011487:Protein Conformation; D011817:Rabbits; D051381:Rats; D012177:Retinol-Binding Proteins; D014801:Vitamin A; D014961:X-Ray Diffraction
D012177:Retinol-Binding Proteins; D014801:Vitamin A