Melatonin inhibits prostaglandin E release from the medial basal hypothalamus of pinealectomized rats.
The effects of pinealectomy and of melatonin administration on prostaglandin E synthesis in the medial basal hypothalamus were studied in male rats. Melatonin treatment significantly decreased prostaglandin E release from the medial basal hypothalamus in pinealectomized rats. The results of the present study suggest that melatonin modulates hypothalamo-hypophyseal function, at least in part, via inhibition of hypothalamic prostaglandin synthesis.
D000818:Animals; D007033:Hypothalamus, Middle / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008027:Light; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D010870:Pineal Gland / Q000502:physiology*; D011458:Prostaglandins E / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D011458:Prostaglandins E; D008550:Melatonin