title: The effect of oral contraceptives on rat platelet membrane glycoproteins.
abstract: Female rats were administered oral contraceptives and the levels of sialic acid on platelet membrane and granule glycoproteins were compared to controls using a sialic acid assay and a fluorescein-conjugated wheat germ agglutinin binding assay and also by measuring the binding of 125I-labelled wheat germ agglutinin to glycoprotein bands from platelets separated by polyacrylamide electrophoresis. The contraceptive-treated rats showed increased levels of glycoprotein sialylation which may partly explain the altered physiological function of the platelets.
mesh_terms: D000818:Animals; D001665:Binding Sites; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003278:Contraceptives, Oral, Hormonal / Q000494:pharmacology*; D005260:Female; D006023:Glycoproteins / Q000097:blood*; D037102:Lectins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012794:Sialic Acids / Q000097:blood; D014909:Wheat Germ Agglutinins
chemical_list: D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D006023:Glycoproteins; D037102:Lectins; D012794:Sialic Acids; D014909:Wheat Germ Agglutinins