[Comparative evaluation of the action of nonsteroidal anti-inflammatory preparations on blood plasma kallikrein and the biological effects of bradykinin].
A study was made of the effects of voltaren, naproxen, flurbiprophen and ibuprophen comparatively to those of acetylsalicylic acid, butadion and indomethacin on the reactions of kininogenesis and biological effects of bradykinin. It was found that in therapeutic concentrations (10(-6)-10(-2) M), the drugs do not inhibit BAEE-esterase activity but nonspecifically inhibit (with the exception of flurbiprophen and butadion) the kininogenase activity of the highly purified human blood plasma kallikrein. A good agreement was discovered in rats between the anti-inflammatory action and protective effect of the drugs on the toxicity of the kininogenesis stimulant, cellulose sulfate. When administered in effective concentrations and doses these drugs exerted an unmarked inhibitory effect on the degree of the spasmogenous and microcirculatory reactions to exogenous bradykinin.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001920:Bradykinin / Q000494:pharmacology*; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D002482:Cellulose / Q000031:analogs & derivatives / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007610:Kallikreins / Q000097:blood*; D007704:Kininogens / Q000097:blood; D007705:Kinins / Q000096:biosynthesis; D008297:Male; D051381:Rats; D014599:Uterus / Q000187:drug effects
D000893:Anti-Inflammatory Agents; D007704:Kininogens; D007705:Kinins; D002482:Cellulose; C020254:cellulose sulfate; D002265:Carboxylic Ester Hydrolases; C019763:benzoylarginine ethyl esterase; D007610:Kallikreins; D001920:Bradykinin
Sravnitel'naia otsenka deĭstviia nesteroidnykh protivovospalitel'nykh preparatov na kallikrein plazmy i biologicheskie éffekty bradikinina.