[Mechanisms of the inhibitory effect of clonidine on the reproductive system of female rats].
It has been demonstrated in experiments on puberal and infantile female rats that a single subcutaneous injection of clonidine (0.03 mg/kg) disturbed whereas in a dose of 1 mg/kg completely inhibited spontaneous or induced ovulation as well as sexual receptivity. When injected in a daily dose of 0.03 mg/kg to puberal rats for 8 days clonidine potentiated the total gonadotropic activity of the pituitaries. When injected in a daily dose of 0.5 mg/kg for 10 days the drug induced the disorders of the estrous cycle during diestrus.
D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004971:Estrus / Q000187:drug effects; D005260:Female; D008297:Male; D010053:Ovary / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013997:Time Factors; D014599:Uterus / Q000187:drug effects
D003000:Clonidine
Izuchenie mekhanizmov ugnetaiushchego vliianiia klonidina na reproduktivnuiu sistemu krys-samok.