[Automatic finger plethysmography as a human pharmacologic research tool. A methodologic study].
In view of the use of an electronically processed digital plethysmography as a noninvasive pharmacological tool - particularly to measure effects of organic nitrates - 9 healthy young volunteers were examined. The purpose of the investigation was to study baseline recordings and to assess the effects of several well defined exogenous influences. The electronic processor calculated the D/H-ratio of each plethysmographic pulse wave, where D represents the depth of the dicrotic minimum measured from the apex of the systolic maximum and H the total hight of the plethysmographic wave. The D/H-ratio was not significantly influenced by a hot beverage, but fell after a cold drink. In undisturbed volunteers the D/H-ratio had a tendency to fall slightly during a 3-h period of observation. This tendency could be eliminated by small doses of pindolol or dihydroergotamine, but individual fluctuations of the curves were still visible. It appears therefore that a fully automated evaluation of plethysmographic recordings yields best results if the findings in a group of volunteers are averaged.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004087:Dihydroergotamine / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D005260:Female; D005385:Fingers / Q000098:blood supply*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D010869:Pindolol / Q000494:pharmacology; D010991:Plethysmography / Q000295:instrumentation*; D011674:Pulse / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects*; D013696:Temperature; D013997:Time Factors
D000431:Ethanol; D004087:Dihydroergotamine; D010869:Pindolol
Die automatisierte Fingerplethysmographie als human pharmakologisches Forschungsinstrument. Eine methodologische Untersuchung.