Prevention of elastase-induced emphysema by aerosol administration of a specific synthetic elastase inhibitor.
The effect of a synthetic elastase inhibitor was studied in experimental emphysema. The development of emphysema was totally prevented by this material. In the authors' opinion the administration of synthetic elastase inhibitors can be considered as a new possibility in the treatment of pulmonary emphysema.
D000336:Aerosols; D000590:Amino Acid Chloromethyl Ketones / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D008168:Lung / Q000473:pathology; D008297:Male; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors* / Q000633:toxicity; D011656:Pulmonary Emphysema / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats
D000336:Aerosols; D000590:Amino Acid Chloromethyl Ketones; C026704:methoxysuccinyl-alanyl-alanyl-prolyl-valine chloromethyl ketone; D010196:Pancreatic Elastase