title: [Effect of isolation stress on ethanol pharmacodynamics in the blood of rats].
abstract: Head space chromatography was used to study the rate of ethanol excretion as criterion of the activity of the ethanol-oxidizing enzymatic system. Isolational stress was shown to be one of the factors determining induction of the ethanol-oxidizing erzymatic systems. The isolation-induced activity of these systems was reduced by diazepam administration. This fact may evidence the existence of central regulation of the activity of the enzymatic systems that metabolize ethanol.
mesh_terms: D000818:Animals; D000431:Ethanol / Q000097:blood*; D006801:Humans; D007700:Kinetics; D008297:Male; D051381:Rats; D012149:Restraint, Physical; D012934:Social Isolation; D013315:Stress, Psychological / Q000097:blood*; D013997:Time Factors
chemical_list: D000431:Ethanol
vernacular_title: Vliianie izoliatsionnogo stressa na farmakokinetiku étanola v krovi krys.