title: Metaplasia. An overview.
abstract: Metaplastic changes are common lesions found at widespread locations, occurring in both reactive and neoplastic tissues. Metaplasia has the following characteristics: (1) it can arise not only as a proliferation and transformation of immature (stem) cells, but also as a direct or indirect transformation of mature cells; (2) through metaplasia, a given cell may exhibit epithelial, mesothelial, or mesenchymal characteristics, regardless of the tissue of origin; and (3) its importance lies in that metaplastic changes can often be symptomatic and may simulate tumors clinically, grossly, or histologically.
mesh_terms: D002454:Cell Differentiation; D002455:Cell Division; D004702:Endocrine Glands / Q000473:pathology; D006801:Humans; D008679:Metaplasia / Q000473:pathology*; D009130:Muscle, Smooth / Q000473:pathology