Antagonism of the effect of delta sleep-inducing peptide by naloxone in the rat.
The somnogenic properties of delta sleep-inducing peptide (DSIP) were investigated using electroencephalographic criteria. The peptide caused a significant increase in both REM and non-REM sleep at the expense of waking when injected into the lateral ventricle of the rat brain in four doses of 5 micrograms during the dark (waking) phase of the light/dark cycle. Furthermore this sleep promoting effect was blocked by pre-treatment with the opiate antagonist naloxone at a dose level (0.1 mg/Kg s.c.) considered selective for mu-receptors.
D000818:Animals; D003701:Delta Sleep-Inducing Peptide; D004569:Electroencephalography; D004576:Electromyography; D007276:Injections, Intraventricular; D009270:Naloxone / Q000494:pharmacology*; D009842:Oligopeptides / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D009842:Oligopeptides; D009270:Naloxone; D003701:Delta Sleep-Inducing Peptide