The role of bile and digestive juices in cadmium effect on the absorption processes in rat small intestine.
The effects of bile and digestive juices was studied on the intestinal absorption of water, sodium and glucose in the small intestine of rats after their intoxication with one dose of cadmium 1.33 mg/kg of body weight injected intravenously. The investigations were carried out on 60 rats by the method of intestinal perfusion. The obtained results showed that cadmium inhibited the intestinal absorption of these substances. Bile and digestive juices abolished partially this effect during their physiological secretion. After administration of cholagogues no protective role of bile and digestive juices was observed alleviating the toxic effects of cadmium, and the intestinal absorption was even more reduced.
D000818:Animals; D001646:Bile / Q000502:physiology*; D001834:Body Water / Q000378:metabolism; D002104:Cadmium / Q000494:pharmacology*; D004063:Digestion; D005947:Glucose / Q000378:metabolism; D007082:Ileum / Q000502:physiology; D007408:Intestinal Absorption / Q000187:drug effects*; D007421:Intestine, Small / Q000187:drug effects / Q000502:physiology*; D007583:Jejunum / Q000502:physiology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism
D002104:Cadmium; D012964:Sodium; D005947:Glucose