title: Efficacy of ivermectin in injectable and oral paste formulations against eight-week-old Strongylus vulgaris larvae in ponies.
abstract: A controlled test method was used to evaluate the efficacy of injectable micelle and oral paste formulations of ivermectin (22,23-dihydroavermectin B1) against 8-week-old Strongylus vulgaris larvae in experimentally infected pony foals. The dosage level of the drug in both formulations tested was 0.2 mg/kg. Ponies were euthanatized and necropsied 5 weeks after treatment. Based on the recovery of live vs dead S vulgaris from mesenteric arteries, both formulations were greater than 99% effective. Increased weight gains and marked reductions in the severity of arterial lesions were observed in treated ponies.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000494:pharmacology; D006736:Horses; D007273:Injections, Intramuscular / Q000662:veterinary; D007559:Ivermectin; D007783:Lactones / Q000008:administration & dosage* / Q000494:pharmacology; D007814:Larva / Q000187:drug effects; D008823:Micelles; D009824:Ointments; D013319:Strongyle Infections, Equine / Q000188:drug therapy* / Q000469:parasitology; D013320:Strongyloidea / Q000187:drug effects*
chemical_list: D000871:Anthelmintics; D007783:Lactones; D008823:Micelles; D009824:Ointments; D007559:Ivermectin