title: [Comparative pharmacokinetics and biologic availability of paracetamol as suppositories].
abstract: After a single dose administration of either 4 suppositories Dolarist -250 (a total of 1000 mg paracetamol, N-acetyl-p-aminophenol) or 4 suppositories of a reference drug registered according to AMG 1976 (a total of 800 mg paracetamol) in 6 healthy subjects, the serum concentrations of paracetamol were determined until 24 h post application. The main pharmacokinetic parameters and the relative bioavailability were calculated. The maximum concentrations of both drugs were similar, however, with Dolarist-250 the serum levels observed after 3, 4, 6 and 8 h were significantly higher. The invasion and elimination rate as well as the relative bioavailability showed no relevant differences.
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D000328:Adult; D001682:Biological Availability; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D013488:Suppositories; D013997:Time Factors
chemical_list: D013488:Suppositories; D000082:Acetaminophen
vernacular_title: Vergleichende Pharmakokinetik und Bioverfügbarkeit von Paracetamol aus Suppositorien.