Cutaneous and pulmonary reactivity in cholinergic urticaria.
Cutaneous and pulmonary reactions to mediators of inflammation were studied in twenty-one patients with cholinergic urticaria, in twenty patients with other types of urticaria, and in seventeen healthy controls. Compared with controls and patients with moderate disease, patients severely affected by cholinergic urticaria or other types of urticaria developed larger weals at sites of injection with histamine (9 X 10(-7) M), but not with compound 48/80 (0.1%), acetylcholine (7 X 10(-5) M), kallikrein (4 X 10(-10) M). On bronchial challenge with acetylcholine (7 X 10(-5) M), pulmonary resistance increased markedly only in severely affected cholinergic urticaria patients. There was no correlation between cutaneous and pulmonary reactivity in individual subjects. Patients with cholinergic urticaria therefore demonstrate features of heightened skin reactivity (shared by patients with other urticarias) and an increased bronchial reactivity (as found in latent asthmatics).
D000109:Acetylcholine; D000255:Adenosine Triphosphate; D001985:Bronchial Provocation Tests; D006632:Histamine; D006801:Humans; D007610:Kallikreins; D008168:Lung / Q000503:physiopathology*; D012129:Respiratory Function Tests; D012867:Skin / Q000503:physiopathology*; D012882:Skin Tests; D014581:Urticaria / Q000503:physiopathology*; D003189:p-Methoxy-N-methylphenethylamine
D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine; D000255:Adenosine Triphosphate; D007610:Kallikreins; D000109:Acetylcholine