[New prospects in the use of hormonal preparations for the regulation of immunogenesis].
It was shown in experiments on 32 CBA mice and 84 guinea-pigs that testosterone and its metabolite dihydrotestosterone differently change the content of the splenic antibody-forming cells, i. e. testosterone lowers and dihydrotestosterone elevates this index. Adrenalectomy of guinea-pigs exerts a temporary intensifying effect on cell immunity (delayed type hypersensitivity) and increases the sensitivity to thymozine stimulating action. Administration of hydrocortisone and the mineralocorticoid DOCA in substituting doses to adrenalectomized guinea-pigs allowed one to establish that the change in cell immunity and thymozine sensitivity is caused by a fall of the glucocorticoid hormone level. The data obtained offer new possibilities of performing purposeful regulation of cellular and humoral immunity.
D000315:Adrenalectomy; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000276:immunology*; D004347:Drug Interactions; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000139:chemically induced; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology*; D013739:Testosterone / Q000031:analogs & derivatives / Q000494:pharmacology*; D045165:Testosterone Congeners / Q000494:pharmacology; D013947:Thymosin / Q000494:pharmacology*
D045165:Testosterone Congeners; D013739:Testosterone; C013915:boldenone; D013947:Thymosin
Novye perspektivy ispol'zovaniia gormonal'nykh preparatov dlia reguliatsii immunogeneza.