Atypical neuroleptics clozapine and thioridazine enhance amphetamine-induced stereotypy.
The effects of the atypical neuroleptics clozapine and thioridazine and the typical neuroleptic pimozide on amphetamine-induced behavior were examined. Pimozide, as expected, blocked both amphetamine-induced locomotion and stereotypy. Thioridazine and clozapine antagonized the increases in locomotion produced by amphetamine, but produced increases in amphetamine-induced stereotypy and lowered the threshold dose for stereotypy. It is suggested that the increased stereotypy might partly account for the decreased locomotion, and that this might be a primary effect of these atypical neuroleptics. The data would also suggest that the use of amphetamine-induced stereotypy as a model for psychosis is inappropriate, as clozapine and thioridazine, which enhance stereotypy, are antipsychotic.
D000818:Animals; D003024:Clozapine / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology*; D003984:Dibenzazepines / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010868:Pimozide / Q000494:pharmacology; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*; D013881:Thioridazine / Q000494:pharmacology*; D013997:Time Factors
D003984:Dibenzazepines; D010868:Pimozide; D003024:Clozapine; D013881:Thioridazine; D003913:Dextroamphetamine