Ivermectin as an antiparasitic agent in cattle.
In experimental trials on cattle, ivermectin given SC at 200 micrograms/kg had 95% or better efficacy against adult and immature GI and pulmonary nematodes, including inhibited fourth-stage larvae of Ostertagia ostertagi. Studies of efficacy against ectoparasites revealed nearly 100% efficacy against sucking lice, psoroptic and sarcoptic mange mites and cattle grubs. Safety trials revealed no adverse effects with the recommended dosage, including bulls and pregnant cows. A few grub-infested cattle died from acute esophagitis associated with a host-parasite reaction after ivermectin injection.
D000818:Animals; D000854:Anoplura / Q000302:isolation & purification; D000871:Anthelmintics / Q000627:therapeutic use; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D004175:Diptera / Q000302:isolation & purification; D004478:Ectoparasitic Infestations / Q000188:drug therapy / Q000662:veterinary*; D005260:Female; D007306:Insecticides / Q000627:therapeutic use; D007559:Ivermectin; D007783:Lactones / Q000627:therapeutic use*; D008925:Mites / Q000302:isolation & purification; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D011247:Pregnancy
D000871:Anthelmintics; D007306:Insecticides; D007783:Lactones; D007559:Ivermectin