[Role of cholinergic systems in the formation of a dissociated state in response to kleregil].
During learning in a T-maze, rats administered cleregil (150 mg/kg, i.p.) developed a dissociated state where the reflex manifested itself only after the substance injection and did not occur without it. Atropine, amizil, alpha-methyl-DOPA and piracetam were established to be able to replace cleregil, thus restoring the conditioned reflex upset by cleregil withdrawal, as well as to eliminate the manifestations of aggressiveness, fear and anxiety caused by prolonged injection of cleregil. Meanwhile depakin and beta-ethyl-diphacil had no effect on behavioral abnormalities, whereas arecoline made them more demonstrable. It is assumed that M-cholinergic system plays the most important role in the mechanism by which the dissociated state is formed.
D000647:Amnesia / Q000139:chemically induced; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003214:Conditioning, Classical / Q000187:drug effects; D003642:Deanol / Q000494:pharmacology*; D004213:Dissociative Disorders / Q000139:chemically induced*; D004338:Drug Combinations / Q000494:pharmacology; D004983:Ethanolamines / Q000494:pharmacology*; D005971:Glutamates / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects*; D013997:Time Factors
D004338:Drug Combinations; D004983:Ethanolamines; D005971:Glutamates; D011950:Receptors, Cholinergic; D003642:Deanol; C043253:deanol aceglutamate
Rol' kholinergicheskikh sistem v formirovanii dissotsiirovannogo sostoianiia k kleregilu.