Vasomotor escape from noradrenaline in the renal, mesenteric and hindquarter vascular beds in spontaneously hypertensive rats (SHR).
During 10 minutes of infusion of noradrenaline in doses of 0.1, 0.2, 0.4 and 0.6 micrograms/min into isolated intestinal, kidney and hindquartet preparation, perfused with aerated Tyrode's solution and escape effect was observed in normotensive rats. The escape was significantly reduced in intestinal and renal vascular beds or disappeared in spontaneously hypertensive rats.
D000818:Animals; D005121:Extremities / Q000098:blood supply; D006973:Hypertension / Q000503:physiopathology*; D007422:Intestines / Q000098:blood supply; D007668:Kidney / Q000098:blood supply*; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR; D013152:Splanchnic Circulation; D014666:Vasomotor System / Q000503:physiopathology*
D009638:Norepinephrine