title: Endotoxin contamination of Foley catheters associated with fevers following transurethral resection of the prostate.
abstract: In 1980 an investigation was conducted due to an apparent cluster of fevers following transurethral resections of the prostate ( TURP ), where the presence of prostatitis or urinary tract infections ( UTIs ) could not account for most cases, and the usage of antimicrobials did not prevent them. When unused, prepackaged , sterilized samples from 13 lots of triple lumen catheters were analyzed, four were found to contain high levels of endotoxin (ET), with a range of 49,150-greater than or equal to 6.25 ng/catheter. Additionally, these lots were highly pyrogenic to rabbits. The maximum incidence of febrile patients (42%) correlated with usage of catheters from the lot where ET levels were the highest. The febrile rate for a second urologist, who used single lumen catheters, was less (12/33 v 0/12). Further consideration should be given to sterile operative equipment which may still be pyrogenic.
mesh_terms: D000368:Aged; D000818:Animals; D003558:Cystoscopy / Q000009:adverse effects; D004731:Endotoxins; D005334:Fever / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011183:Postoperative Complications; D011468:Prostatectomy / Q000379:methods; D011749:Pyrogens; D011817:Rabbits; D012189:Retrospective Studies; D014521:Urethra; D014546:Urinary Catheterization / Q000009:adverse effects*; D014556:Urine / Q000382:microbiology
chemical_list: D004731:Endotoxins; D011749:Pyrogens