title: Effects of immersion in cholesterol-lipid solution on the tensile and fatigue properties of elastomeric polymers for blood pump applications.
abstract: Tensile and fatigue properties were studied on three kinds of segmented polyether polyurethanes developed for blood pump applications. To study the effects of plasma constituents, specimens were immersed in a cholesterol-lipid solution whose composition is similar to that of plasma. The results obtained were compared with those observed in a saline solution which had been reported previously. Immersion in the cholesterol-lipid solution has influence on the mechanical properties of Toyobo TM5 polyurethane and Avcothane 51: Its effect is enhanced by cyclic deformation. Cholesterol-lipids change the mechanical characteristics of Avcothane 51 more remarkably than those of Toyobo TM5 polyurethane possibly because the former contains about 10% silicone. On the other hand, there is little effect of the constituents of the cholesterol-lipid solution on the static and dynamic mechanical properties of Biomer, although moisture and cyclic deformation have some influence on the mechanical characteristics.
mesh_terms: D001243:Assisted Circulation; D001672:Biocompatible Materials; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002784:Cholesterol; D006353:Heart-Assist Devices; D008055:Lipids; D011108:Polymers; D011140:Polyurethanes; D012826:Silicone Elastomers; D012996:Solutions; D013718:Tensile Strength
chemical_list: D001672:Biocompatible Materials; D008055:Lipids; D011108:Polymers; D011140:Polyurethanes; D012826:Silicone Elastomers; D012996:Solutions; C000144:Avcothane; C031892:biomer; D002784:Cholesterol