title: Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase.
abstract: A new class of synthetic antifungal agents, the allylamines , has been developed by modification of naftifine , a topical antimycotic. SF 86-327, the most effective of these compounds so far, is highly active in vitro against a wide range of fungi and exceeds clinical standards in the oral and topical treatment of guinea pig dermatophytoses. SF 86-327 is a powerful specific inhibitor of fungal squalene epoxidase, a key enzyme in sterol biosynthesis.
mesh_terms: D000499:Allylamine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D000588:Amines / Q000138:chemical synthesis*; D000818:Animals; D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D003881:Dermatomycoses / Q000188:drug therapy; D005658:Fungi / Q000187:drug effects* / Q000201:enzymology; D006168:Guinea Pigs; D009281:Naphthalenes / Q000138:chemical synthesis / Q000494:pharmacology; D010105:Oxygenases / Q000037:antagonists & inhibitors*; D050603:Squalene Monooxygenase; D000077291:Terbinafine
chemical_list: D000588:Amines; D000935:Antifungal Agents; D009281:Naphthalenes; D000499:Allylamine; C029178:naftifine; C041358:SAN 85-190; D010105:Oxygenases; D050603:Squalene Monooxygenase; D000077291:Terbinafine