The fate of drotaverine-acephyllinate in rat and man. II. Human pharmacokinetics of drotaverine-14C-acephyllinate.
Pharmacokinetics of Drotaverine-Acephyllinate, Chinoin was investigated in seven male volunteers using 14C labelled drug. Drotaverine-Acephyllinate was administered at a 100 mg single oral dose. Measurements of total radioactivity showed that the drug was absorbed completely and was eliminated by renal and biliary routes. Within 72 hours 39.9 +/- 9.9% and 47.1 +/- 4.9% of the dose were recovered in the urine and faeces respectively. Experimental results were interpreted on the basis of a complex linear compartment model. The structural identifiability of the model was proved by computer analysis, and the pharmacokinetic parameters were determined.
D000284:Administration, Oral; D000328:Adult; D004338:Drug Combinations / Q000097:blood / Q000378:metabolism / Q000652:urine; D005243:Feces / Q000032:analysis; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D010208:Papaverine / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000652:urine; D011485:Protein Binding; D012984:Software; D013806:Theophylline / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000652:urine
D004338:Drug Combinations; C034813:drotaverine, acephyllinate drug combination; D013806:Theophylline; D010208:Papaverine