title: Transport of glutathione by intestinal brush border membrane vesicles.
abstract: Intestinal brush border membranes prepared from pig jejunum were shown to transport intact reduced glutathione into an osmotically responsive intravesicular space. At early incubation time (under 1 min.) GSH was poorly hydrolysed in its free amino acids. Primarily glutathione uptake was obtained against a concentration gradient (vesicle greater than medium) and was stimulated by Na+.
mesh_terms: D000818:Animals; D001692:Biological Transport; D003545:Cysteine / Q000031:analogs & derivatives*; D004151:Dipeptides; D005033:Ethylmaleimide / Q000031:analogs & derivatives; D005978:Glutathione / Q000378:metabolism*; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism*; D007700:Kinetics; D008871:Microvilli / Q000378:metabolism*; D009842:Oligopeptides; D009994:Osmolar Concentration; D013552:Swine
chemical_list: D004151:Dipeptides; D009842:Oligopeptides; C042944:N-ethylmaleimide-gamma-glutamyl-cysteinyl-glycine; C042945:N-ethylmaleimide-cysteine; C042946:N-ethylmaleimide-cysteinyl-glycine; D005978:Glutathione; D003545:Cysteine; D005033:Ethylmaleimide