[Hyperthermic radiosensitization of a strain of hematopoietic cells from mouse bone marrow, CFU-S].
Employing the technique of the spleen colony-formation the authors investigated the survival curve of the mouse hematopoietic stem cells resulting from increasing doses of X rays (D0 = 0.79 Gy and n = 1.59). The effect of the hyperthermic radiosensitization was measured by comparison with the effects observed in the irradiated CFU-S population previously exposed to hyperthermia. The treatment lasted 60 minutes at 42 degrees C and 12 minutes at 44 degrees C considering the thermal inactivation kinetics in such a way that the survival rate were the same in both cases. The results obtained for D0 = 0.52 Gy and n = 1.0 during 60 minutes at 42 degrees C, and for D00 = 0.61 Gy and n = 1.0 during 12 minutes at 44 degrees C showed that: 1) a synergic effect upon the CFU-S population is produced by the combination of hyperthermia and radiation, 2) for the same survival rate, the radiosensitivity increase produced after the thermic treatment a 42 degrees C and 44 degrees C is of the same order, and 3) such treatments, in both cases, produced a loss of a radioinduced sublethal damage accumulation.
D000818:Animals; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D006412:Hematopoietic Stem Cells / Q000528:radiation effects*; D006358:Hot Temperature; D007700:Kinetics; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011836:Radiation Tolerance
Radiosensibilización hipertérmica de las células cepa hematopoyéticas de medula ósea de ratón "CFU-S".