The effects of erythrocyte contamination on pokeweed mitogen induced immunoglobulin synthesis in man.
Red blood cell (RBC) contamination of cultures of peripheral blood mononuclear cells does not suppress pokeweed mitogen (PWM) induced immunoglobulin synthesis. At supra-optimal doses of PWM immunoglobulin production is enhanced in the presence of RBCs. The degree of RBC contamination is a factor to be considered in interpreting the results obtained with PWM induced Ig synthesis in disease.
D000921:Antibody-Producing Cells / Q000276:immunology / Q000378:metabolism; D004912:Erythrocytes; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism*; D011043:Pokeweed Mitogens / Q000494:pharmacology*
D007136:Immunoglobulins; D011043:Pokeweed Mitogens