title: Comparison of the Lumadex-foam stability index test, lecithin: sphingomyelin ratio, and simple shake test for fetal lung maturity.
abstract: Amniotic fluid was obtained from 269 patients within 72 hours of delivery. The sensitivity, specificity, and predictive value of the Lumadex-foam stability index test, lecithin: sphingomyelin (L:S) ratio, and simple shake test were assessed in the diagnosis of respiratory distress syndrome (RDS), as well as the accuracy in identification of functional lung maturity in the growth-retarded fetus. The Lumadex-foam stability index test was found to be an accurate, quantitative, simple, and rapid measure of fetal lung maturity in the normal as well as abnormal pregnancy. The L:S ratio was accurate in the normal pregnancy, but became inaccurate in the small growth-retarded fetus. The nonquantitative simple shake test was accurate when it indicated fetal lung maturity, but an immature result was meaningless because of the large false-negative rate.
mesh_terms: D000653:Amniotic Fluid / Q000032:analysis*; D003951:Diagnostic Errors; D005260:Female; D005325:Fetal Organ Maturity; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000196:embryology*; D010713:Phosphatidylcholines / Q000032:analysis*; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*; D012127:Respiratory Distress Syndrome, Newborn / Q000175:diagnosis*; D013109:Sphingomyelins / Q000032:analysis*
chemical_list: D010713:Phosphatidylcholines; D013109:Sphingomyelins