[Stimulant of antibody producers isolated from the supernatants of cell cultures of normal human bone marrow and in various diseases].
The biological activity of a stimulant of antibody producers (SAP) isolated from normal human bone marrow was studied and compared with that of a stimulant of antibody producers from the bone marrow of patients with acute myeloblastic leukemia, acute lymphoblastic leukemia, lymphosarcoma, and multiple myeloma. The activity of the SAP from human bone marrow in health was similar to that of analogous transmitters from the bone marrow of other species of the mammals and birds. The activity of the SAP in patients with multiple myeloma was elevated, whereas in patients with acute myeloblastic leukemia, it was lowered.
D000276:Adjuvants, Immunologic / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects*; D001853:Bone Marrow / Q000276:immunology*; D002478:Cells, Cultured; D002850:Chromatography, Gel; D006801:Humans; D007114:Immunization; D008232:Lymphoproliferative Disorders / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA
D000276:Adjuvants, Immunologic
Stimuliator antiteloprodutsentov, vydelennyĭ iz supernatantov kul'tur kletok kostnogo mozga cheloveka v norme i pri razlichnykh zabolevaniiakh.