Properdin factor B (Bf) polymorphism: subtyping of SS phenotypes.
The authors have studied the genetic polymorphism of the properdin factor B (Bf) by the isoelectrofocusing technique. The SS phenotypes, all similar on agarose gel electrophoresis, were shown to be heterogeneous after isoelectrofocusing; this heterogeneity corresponds to the expression of two new suballeles SA and SB, inherited in a codominant manner. Gene frequencies for 121 individuals with SS phenotype are 0.57 for SA, and 0.43 for SB.
D000483:Alleles; D011415:Complement Factor B / Q000235:genetics*; D004792:Enzyme Precursors / Q000235:genetics*; D005787:Gene Frequency; D006801:Humans; D007525:Isoelectric Focusing; D010641:Phenotype; D011110:Polymorphism, Genetic
D004792:Enzyme Precursors; D011415:Complement Factor B