title: [Antidepressive effect of a Hypericum extract standardized to an active hypericine complex. Biochemical and clinical studies].
abstract: In 6 women with depressive symptoms aged 55-65 years the effect on the excretion of urinary metabolits of noradrenaline and dopamine was measured after a monotherapy with the active hypericine complex (Psychotonin M). In all patients there was a significant increase in 3-methoxy-4-hydroxyphenylglucol which is considered an expression of a beginning antidepressive reaction. With the same patients supplemented with further 9 cases the clinical influence on the depression was measured during a period of 4-6 weeks, with the rating-scales SCAG (Clinical assessment geriatric scale) and DSI (Depression Status Inventory) there was shown a quantitative improvement of the items anxiety, dysphoric mood, loss of interest, hypersomnia, anorexia, depression regularly worse in the morning, insomnia, obstipation, psychomotoric retardation and feeling of worthlessness.
mesh_terms: D000328:Adult; D000368:Aged; D000873:Anthracenes; D000928:Antidepressive Agents / Q000627:therapeutic use*; D001551:Benz(a)Anthracenes / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000378:metabolism; D004562:Electrocardiography; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000097:blood; D008875:Middle Aged; D010569:Perylene / Q000031:analogs & derivatives / Q000627:therapeutic use*; D010936:Plant Extracts / Q000627:therapeutic use*
chemical_list: D000873:Anthracenes; D000928:Antidepressive Agents; D001551:Benz(a)Anthracenes; D010936:Plant Extracts; D008734:Methoxyhydroxyphenylglycol; D010569:Perylene; C004965:hypericin
vernacular_title: Antidepressive Wirkung eines auf den Wirkstoffkomplex Hypercin standardisierten Hypericum-Extraktes. Biochemische und klinische Untersuchungen.