[Hypnogenic properties of the delta-sleep peptide and its structural analogs].
It has been demonstrated in unrestrained rabbits that the delta-sleep-inducing peptide (DSIP, 60 micrograms, intraventricularly) produced sleep lasting 55-65 min. At that time the amount of delta-waves on the EEG was 230 % of the initial level. Of the 22 structural analogs of DSIP, the DPhe-containing compound compared favourably with the delta-sleep-inducing peptide as regards the activity. Other analogs were either less active or had no hypnogenic activity at all.
D000818:Animals; D001921:Brain / Q000187:drug effects; D003700:Delta Rhythm; D003701:Delta Sleep-Inducing Peptide; D004569:Electroencephalography; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D011817:Rabbits; D012890:Sleep / Q000187:drug effects; D013329:Structure-Activity Relationship; D013997:Time Factors
D006993:Hypnotics and Sedatives; D009842:Oligopeptides; D003701:Delta Sleep-Inducing Peptide
Issledovanie gipnogennykh svoĭstv peptida del'ta-sna i ego strukturnykh analogov.