Mutagenicity of antiepileptic drugs. II. Phenytoin, primidone and phenobarbital.
The antiepileptic drugs, phenytoin, primidone and phenobarbital, were tested in Chinese hamster ovary (CHO) cells for their ability to induce sister-chromatid exchanges (SCEs) and structural chromosomal aberrations (CAs), with and without metabolic activation. SCEs and CAs were analyzed in the same cell population. The results are negative.
D000818:Animals; D001711:Biotransformation; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006224:Cricetinae; D005260:Female; D009154:Mutation / Q000187:drug effects*; D010053:Ovary; D010634:Phenobarbital / Q000633:toxicity*; D010672:Phenytoin / Q000633:toxicity*; D011324:Primidone / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000187:drug effects
D011324:Primidone; D010672:Phenytoin; D010634:Phenobarbital