title: A method facilitating the demonstration of synergism in the tissue-responses to mixed peptide stimuli.
abstract: A methodology for the pharmacodynamical assay of mixtures of 2 spasmogenic peptides is described, illustrated and discussed, with reference to a method intended for the chemists (P. Job, 1927). This allows a quick appreciation of the existence of synergism, of its own order of magnitude and of that of the doses for which it is significant. Also given is a fast way of curve-fitting the dose response to individual peptides, according to Clark's approximation.
mesh_terms: D000799:Angioedema / Q000503:physiopathology; D000818:Animals; D001920:Bradykinin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D046911:Macromolecular Substances; D008766:Methylmannosides / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000502:physiology; D009194:Myeloma Proteins; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014312:Trisaccharides / Q000494:pharmacology
chemical_list: D046911:Macromolecular Substances; D008766:Methylmannosides; D009194:Myeloma Proteins; D010455:Peptides; D014312:Trisaccharides; C045441:isomaltotriose; C008466:methylmannoside; D001920:Bradykinin