title: Genetic linkage between malathion and dieldrin resistance in Anopheles arabiensis.
abstract: A strain of Anopheles arabiensis resistant to both malathion and dieldrin was crossed and backcrossed to a susceptible strain. The progeny were tested on each insecticide in turn. Less than 50% mortality in the second insecticide exposure among the backcross progeny indicated linkage between the resistance genes. In a backcross of A. gambiae X A. arabiensis hybrids a recombination rate of 7.5% was observed. A Y-translocation strain of A. arabiensis showed less than 2.8% recombination between the resistance genes. It is impossible to confirm the genotype of apparent recombinants using existing stocks, but the two resistance mechanisms are biochemically distinguishable. If the two genes are very closely linked, linkage disequilibrium could influence the consequences of switching to malathion spraying after dieldrin resistance has evolved.
mesh_terms: D000818:Animals; D000852:Anopheles / Q000187:drug effects* / Q000235:genetics; D004026:Dieldrin / Q000633:toxicity*; D004351:Drug Resistance; D008040:Genetic Linkage; D008294:Malathion / Q000633:toxicity*; D008297:Male; D011995:Recombination, Genetic; D014998:Y Chromosome
chemical_list: D004026:Dieldrin; D008294:Malathion