The effects of single and multiple doses of thiabendazole on growing and arrested stages of the rabbit stomach worm Obeliscoides cuniculi.
Preliminary observations, using 5 rabbits carrying long-standing infections, indicated that single doses of thiabendazole were effective against adult O. cuniculi and that repeated doses may have had some effect on arrested larvae. A multiple dosing regime, consisting of 1 dose at 110 mg kg-1 body weight followed by 8 doses at 70 mg kg-1 body weight at 4-h intervals, was successful in removing 99.12% of developing worms and 86.04% of arrested larvae.
D000818:Animals; D000830:Animals, Laboratory; D004305:Dose-Response Relationship, Drug; D005260:Female; D007814:Larva / Q000187:drug effects; D008297:Male; D011817:Rabbits; D013045:Species Specificity; D013827:Thiabendazole / Q000494:pharmacology* / Q000627:therapeutic use; D014251:Trichostrongyloidea / Q000187:drug effects* / Q000254:growth & development; D014252:Trichostrongyloidiasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*
D013827:Thiabendazole