Acute lymphoblastic leukemia in the offspring of a mother exposed to diethylstilbestrol (DES) in utero. A case report and hypothesis.
A case of a child with acute lymphoblastic leukemia (ALL) is reported. The child's mother was exposed to diethylstilbestrol (DES) in utero during the first two trimesters of pregnancy. Causal association for this child's leukemia could have resulted either from a maternal germ cell event or abnormal DES-induced intrauterine environment.
D000328:Adult; D004054:Diethylstilbestrol; D005260:Female; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000175:diagnosis* / Q000209:etiology; D009369:Neoplasms / Q000235:genetics; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects
D004054:Diethylstilbestrol