Concentrations of cefmetazole in plasma and tissue resulting from peri-incisional administration before appendectomy.
The levels of cefmetazole in plasma and tissue were determined after injection of a dose of 30 mg/kg into the zone of the wound of each of 15 patients undergoing appendectomy. The mean plasma levels of cefmetazole at the start and end of surgery (8.9 +/- 2.4 and 31.7 +/- 6.4 min after dosage) were 21.1 and 59.0 micrograms/ml, respectively; concentrations of the drug were 14.6 and 4,486.9 micrograms/g in skin, 9,165.0 and 1,756.4 micrograms/g in subcutaneous tissue, and 8,669.6 and 2,022.9 micrograms/g in muscle.
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D001062:Appendectomy; D015311:Cefmetazole; D002513:Cephamycins / Q000097:blood* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D009132:Muscles / Q000378:metabolism; D012867:Skin / Q000378:metabolism; D013530:Surgical Wound Infection / Q000517:prevention & control*
D002513:Cephamycins; D015311:Cefmetazole