Philadelphia chromosome-negative chronic myelogenous leukemia with prominent eosinophilic component.
A patient with Philadelphia chromosome-negative chronic myelogenous leukemia and hypereosinophilia was found at autopsy to have multiple splenic tumors composed exclusively of mature and developing eosinophils. This finding indicated a clonal proliferation of the eosinophils and supports the concept that the hypereosinophilia was also a component of the leukemic process.
D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D004802:Eosinophilia / Q000473:pathology*; D004804:Eosinophils; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000473:pathology*; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D009504:Neutrophils; D013154:Spleen / Q000473:pathology