Enhanced xanthine oxidase activity in mice treated with interferon and interferon inducers.
Administration to mice of either interferon (IFN) or IFN inducers resulted in a marked increase of xanthine oxidase (XO) activity in different organs. Dose response studies revealed that serum XO was increased by administration of polyinosylic-polycyticylic acid (poly I-C) at doses as low as 0.1 mg/kg. In view of the well known ability of XO to generate superoxide radicals it is suggested that its induction might play a role in several biological effects of IFN.
D000818:Animals; D004274:DNA, Recombinant; D004305:Dose-Response Relationship, Drug; D007369:Interferon Inducers / Q000494:pharmacology*; D007370:Interferon Type I / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D008297:Male; D051379:Mice; D011070:Poly I-C / Q000494:pharmacology; D014018:Tissue Distribution; D014968:Xanthine Dehydrogenase; D014969:Xanthine Oxidase / Q000097:blood / Q000378:metabolism*
D004274:DNA, Recombinant; D007369:Interferon Inducers; D007370:Interferon Type I; D014968:Xanthine Dehydrogenase; D014969:Xanthine Oxidase; D011070:Poly I-C