Effect of combined systemic antimicrobial therapy and mechanical plaque control in patients with recurrent periodontal disease.
The aim of the present study was to analyze the effect of systemic antimicrobial therapy and mechanical plaque control in patients with recurrent periodontal disease. 9 patients volunteered for the combined therapy. At a baseline examination they were randomly distributed into 2 groups, one given tetracycline therapy for 2 weeks and the other metronidazole therapy for 1 week. A mechanical plaque control program comprising oral hygiene training, professional cleaning of all teeth and subgingival debridement at diseased sites was carried out at the baseline examination and at all recall visits, i.e. once every month during the first 6 months and then after 9, 12, and 18 months. The results demonstrated clinically and microbiologically that a combination of an initial antimicrobial and a continuous systematic mechanical plaque control program may be a valuable therapeutic approach in a strictly selected group of refractory patients. Recurrent periodontal lesions which still displayed severe inflammation despite renewed conventional therapy showed a marked reduction in probing depths, bleeding and suppuration from the pockets, and further, a reduced presence of spirochetes and motile rods during the trial. The results indicate that the level and longevity of success is also related to whether or not self-performed oral hygiene measures are sufficiently carried out. No superior effect of the combined program could be observed in cooperating patients receiving tetracycline as compared with those given metronidazole.
D000328:Adult; D000368:Aged; D001419:Bacteria / Q000166:cytology; D003131:Combined Modality Therapy; D003773:Dental Plaque / Q000517:prevention & control*; D003777:Dental Prophylaxis; D005260:Female; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D008875:Middle Aged; D010518:Periodontitis / Q000188:drug therapy / Q000382:microbiology / Q000628:therapy*; D012008:Recurrence; D013752:Tetracycline / Q000627:therapeutic use*
D008795:Metronidazole; D013752:Tetracycline