Immunoglobulin producing cells in human periapical granulomas.
Ten cases of periapical granuloma were stained for igG, IgA, IgM, IgD and IgE by the unlabelled antibody peroxidase-antiperoxidase complex method to investigate the class distribution of plasma cells within the lesions. The results indicated that IgG containing plasma cells predominated in all lesions and that IgG, IgA, IgM, IgE and IgD cells represented 81.9, 11.4, 5.4, 1.1 and 0.2 per cent respectively, of the total positive cell population. All specimens contained IgE plasma cells in addition to many non-lymphoid cells showing membrane-like staining for IgE. The results suggest that in addition to tissue damage via local deposition of immune complexes IgE mediated immediate hypersensitivity reactions may have a role in pathogenesis.
D006801:Humans; D007070:Immunoglobulin A / Q000378:metabolism; D007072:Immunoglobulin D / Q000378:metabolism; D007073:Immunoglobulin E / Q000378:metabolism; D007074:Immunoglobulin G / Q000378:metabolism; D007075:Immunoglobulin M / Q000378:metabolism; D007136:Immunoglobulins / Q000378:metabolism*; D010484:Periapical Granuloma / Q000276:immunology / Q000473:pathology*; D010950:Plasma Cells / Q000276:immunology*
D007070:Immunoglobulin A; D007072:Immunoglobulin D; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D007073:Immunoglobulin E