The influence of changes in tension on protein synthesis and prostaglandin release in isolated rabbit muscles.
Intermittent stretching of isolated rabbit muscles increased the rate of protein synthesis by 70% and prostaglandin-F2 alpha release by 105%. Both effects of intermittent stretching were blocked by indomethacin and meclofenamate; the absence of Ca2+ together with added EGTA also inhibited both processes. The residual influence of intermittent stretching on protein synthesis was closely correlated with prostaglandin-F2 alpha release, which may be the link between mechanical activity and protein synthesis in skeletal muscle.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D015237:Dinoprost; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008469:Meclofenamic Acid / Q000494:pharmacology; D009119:Muscle Contraction; D009124:Muscle Proteins / Q000096:biosynthesis*; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D011460:Prostaglandins F / Q000378:metabolism*; D011817:Rabbits
D009124:Muscle Proteins; D011460:Prostaglandins F; D008469:Meclofenamic Acid; D015237:Dinoprost; D002118:Calcium; D007213:Indomethacin