Enhancement of immune function and tumor growth inhibition by antibodies against prostaglandin E2.
Mice bearing a Lewis lung carcinoma (LLC) were passively immunized against prostaglandin E2 (PGE2) by administration of rabbit serum containing anti-PGE2 antibodies. The effect of PGE2-immune serum on the suppressed immunity of LLC-bearing mice was examined. Treatment of tumor-bearing mice with anti-PGE2 prevented the suppression of lymphocyte mitogenesis and the alterations in macrophage migration which typically occur in LLC-bearing mice. Furthermore, tumor growth was reduced in LLC-bearing mice which received antibodies directed against PGE2 rather than a placebo treatment.
D000818:Animals; D000906:Antibodies / Q000032:analysis / Q000502:physiology*; D002464:Cell Migration Inhibition; D015232:Dinoprostone; D005260:Female; D007106:Immune Sera / Q000494:pharmacology; D007108:Immune Tolerance; D008175:Lung Neoplasms / Q000276:immunology*; D008213:Lymphocyte Activation; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000276:immunology*; D011458:Prostaglandins E / Q000276:immunology*; D011817:Rabbits
D000906:Antibodies; D007106:Immune Sera; D011458:Prostaglandins E; D015232:Dinoprostone