Prednisolone clearance: a possible determinant for glucocorticoid efficacy in patients with oral vesiculo-erosive diseases.
The pharmacokinetics of prednisolone were determined in 12 patients with oral vesiculo-erosive diseases. The bioavailability of prednisone in these patients exhibited a low intersubject variability, while the metabolic clearance rate of total and of unbound prednisolone varied considerably from patient to patient.
D000328:Adult; D000368:Aged; D001682:Biological Availability; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000188:drug therapy / Q000378:metabolism*; D011239:Prednisolone / Q000008:administration & dosage / Q000378:metabolism*; D011241:Prednisone / Q000008:administration & dosage / Q000378:metabolism*; D014456:Ulcer / Q000188:drug therapy / Q000378:metabolism
D011239:Prednisolone; D011241:Prednisone