Dose-dependent pharmacokinetic study of pefloxacin, a new antibacterial agent, in humans.
A dose-dependent pharmacokinetic study of pefloxacin was performed after four intravenous infusions and four orally administered doses. After intravenous infusion, the pharmacokinetic profiles of the plasma concentrations showed a biphasic decline, with half-lives (mean +/- SD) of 8.55 +/- 4.20 min and 11.50 +/- 1.75 h, respectively. Intravenous infusion and oral administration yielded similar results. The pharmacokinetic parameters remained constant in the dose range of 200-800 mg from the plasma and urine data.
D000284:Administration, Oral; D000890:Anti-Infective Agents / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics; D009268:Nalidixic Acid / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000652:urine; D015366:Pefloxacin
D000890:Anti-Infective Agents; D015366:Pefloxacin; D009268:Nalidixic Acid