[Use of Ommaya reservoirs in the treatment of meningeal relapse of acute lymphoblastic leukemia].
We report our experience in the treatment of meningeal relapses in acute lymphoblastic leukemia (ALL) with intraventricular chemotherapy via an Ommaya reservoir. We treated 5 children in this way with some complications secondary to the use of the reservoir: methotrexate leukoencephalopathy, bacterial meningitis, reservoir malfunction. But patient comfort homogeneous drug distribution when injected via the Ommaya reservoir and the possibility of long term meningeal remission justify the discussion of the use of an Ommaya reservoir use in meningeal relapses in ALL.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007276:Injections, Intraventricular / Q000009:adverse effects / Q000295:instrumentation*; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D008297:Male; D008577:Meningeal Neoplasms / Q000188:drug therapy*; D008581:Meningitis / Q000209:etiology; D008727:Methotrexate / Q000008:administration & dosage* / Q000627:therapeutic use
D008727:Methotrexate
Utilisation des réservoirs d'Ommaya dans le traitement des rechutes méningées des leucémies aiguës lymphoblastiques.