Interferon fever: absence of human leukocytic pyrogen response to recombinant alpha-interferon.
A sensitive in vitro assay for generation of human leukocytic pyrogen has been used to study the pathogenesis of fever accompanying administration of human alpha-interferon. Unlike other potent pyrogens, two recombinant interferon preparations tested over a wide concentration range did not stimulate release of leukocytic pyrogen. This result suggests that interferon may cause fever by a novel mechanism not dependent on leukocytic pyrogen.
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D004285:Dogs; D004731:Endotoxins / Q000633:toxicity; D006801:Humans; D007370:Interferon Type I / Q000235:genetics / Q000633:toxicity*; D007668:Kidney; D007700:Kinetics; D009000:Monocytes / Q000187:drug effects / Q000502:physiology*; D011749:Pyrogens; D011817:Rabbits; D013212:Staphylococcus epidermidis
D004731:Endotoxins; D007370:Interferon Type I; D011749:Pyrogens