Mapping of the c-sis oncogene on human chromosome 22 with respect to the breakpoint associated with chronic myeloid leukaemia.
Chronic myeloid leukaemia (CML) cells are often characterized by the presence of a small chromosome 22, in which most of the q arm has been translocated to chromosome 9. Using cell hybrids containing different parts of chromosome 22 I have mapped the c-sis oncogene, which is known to be situated on chromosome 22, to a region distal to the CML breakpoint (22q112) and proximal to 22q13. This demonstrates that c-sis is translocated to chromosome 9 in CML cells.
D000818:Animals; D002460:Cell Line; D002874:Chromosome Mapping; D002904:Chromosomes, Human, 21-22 and Y / Q000648:ultrastructure*; D002906:Chromosomes, Human, 6-12 and X / Q000648:ultrastructure*; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D007951:Leukemia, Myeloid / Q000235:genetics*; D051379:Mice; D009857:Oncogenes; D014178:Translocation, Genetic