Clinical and biochemical findings in Leber's hereditary optic atrophy.
Clinical findings in Leber's hereditary optic atrophy (LHOA) are reviewed and the results given of treatment with a regimen based on the hypothesis that the disease is a manifestation of cyanide toxicity. Recent biochemical investigations confirm disturbed cyanide metabolism and suggest that zinc deficiency may be implicated.
D000293:Adolescent; D000328:Adult; D002648:Child; D003553:Cystine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006879:Hydroxocobalamin / Q000627:therapeutic use; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009896:Optic Atrophy / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics* / Q000378:metabolism; D012008:Recurrence; D012907:Smoking; D015032:Zinc / Q000097:blood
D003553:Cystine; D015032:Zinc; D006879:Hydroxocobalamin