The effects of topical dinoprostone on the nasal vasculature. A study of patients with allergic rhinitis.
We studied the effects of topical dinoprostone on the nasal blood vessels of patients with allergic rhinitis. The outstanding changes noted were constriction of the arterioles and capillaries (to a lesser extent) and tight closure of the interendothelial junctions. These changes caused a diminution of nasal blood flow and edema fluid formation, a reduction in the size of the turbinates, and consequently, an increase in nasal patency. However, dinoprostone had no effect on the nasal venules.
D000287:Administration, Topical; D015232:Dinoprostone; D006801:Humans; D009296:Nasal Cavity / Q000098:blood supply* / Q000187:drug effects; D011458:Prostaglandins E / Q000494:pharmacology* / Q000627:therapeutic use; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*
D011458:Prostaglandins E; D015232:Dinoprostone