[Cerebral changes shown by computed tomography in children with acute lymphatic leukemia after therapy].
The authors discuss the CT findings of the late brain damage by the radiochemotherapic treatment for the prophylaxis of meningeal leukemia in 50 patients, 1 divided by 15 years old. The more frequent CT findings are: enlargement of the subaracnoid spaces; ventricular dilatation; hypodensity of cerebral parenchima; calcifications. These findings correspond to two clinical and anatomo-pathological conditions: subacute leucoencephalopathy and mineralizing microangiopathy. A greater damage on central nervous system was demonstrated in younger children (5 years old) at the time of prophylaxis of meningeal leukemia, that were irradiated with NSD = 950 ret.
D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001921:Brain / Q000000981:diagnostic imaging / Q000528:radiation effects; D001927:Brain Diseases / Q000000981:diagnostic imaging* / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D008297:Male; D008577:Meningeal Neoplasms / Q000517:prevention & control; D011878:Radiotherapy / Q000009:adverse effects; D013997:Time Factors; D014057:Tomography, X-Ray Computed
D000970:Antineoplastic Agents; D003037:Cobalt Radioisotopes
Alterazioni cerebrali riscontrate con TC in bambini affetti da leucemia linfatica acuta fuori terapia.