Influence of age on the response to increased salt intake: effects on blood pressure and sodium in erythrocytes.
Blood pressure (BP), sodium in erythrocytes (IeNa) and transmembrane sodium fluxes were determined in normotensive 30 and 50-year-old men with a family history of hypertension (group H; n = 17 and 11 respectively) and without such history (group C; n = 15 and 26 respectively) during normal salt intake and after four weeks on ordinary diet plus 12 g NaCl daily. The 50-year-old men showed a significant increase in BP and weight during high salt intake while the younger men did not. On normal salt, group H had a significantly higher IeNa than group C in both age groups. In the younger group this was accompanied by a decreased Na efflux rate constant. IeNa decreased significantly in group H in both age groups. The decrease in IeNa and increase in pump activity in group H during high salt intake does not support the existence of a sodium transport inhibitor. The increase in BP in the older group during high salt indicates that age is an important factor in BP response.
D000328:Adult; D000367:Age Factors; D000375:Aging; D001794:Blood Pressure / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000503:physiopathology; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012964:Sodium / Q000097:blood*; D012965:Sodium Chloride / Q000494:pharmacology*
D012965:Sodium Chloride; D012964:Sodium