Effect of sodium meclofenamate on radiation-induced esophagitis and cystitis.
Stumptailed monkeys (Macaca arctoides) received 2000 rad irradiation to the upper half of the esophagus and to the bladder by a 6-MEV linear accelerator. Endoscopy and biopsy was obtained from these organs weekly for 3 weeks. At the end of this period, the animals were autopsied and histopathologic examination undertaken. Sodium meclofenamate in doses of 5-20 mg/kg/day p.os was found effective in reducing or preventing radiation induced esophagitis and cystitis.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D003556:Cystitis / Q000517:prevention & control*; D004941:Esophagitis / Q000517:prevention & control*; D004947:Esophagus / Q000528:radiation effects; D005260:Female; D008251:Macaca; D008297:Male; D008469:Meclofenamic Acid / Q000627:therapeutic use*; D011448:Prostaglandin Antagonists / Q000627:therapeutic use*; D011832:Radiation Injuries / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D001743:Urinary Bladder / Q000528:radiation effects; D062367:ortho-Aminobenzoates / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D011448:Prostaglandin Antagonists; D011837:Radiation-Protective Agents; D062367:ortho-Aminobenzoates; D008469:Meclofenamic Acid