The pharmacokinetics and tissue penetration of ofloxacin.
The pharmacokinetics of the 4-quinolone agent, ofloxacin, were studied in six healthy volunteers, following a 600 mg oral dose. The levels of the compound were measured by a microbiological assay in serum, blister fluid and urine. The compound was rapidly absorbed, the mean maximum concentration of ofloxacin being 10.7 mg/l at 1.2 h. The mean serum elimination half-life was 7 h and 80.3% of the administered compound was recovered in the urine by 48 h. Ofloxacin penetrated the blister fluid well, the mean peak level being 5.2 mg/l at 5.3 h.
D000328:Adult; D000890:Anti-Infective Agents / Q000009:adverse effects / Q000097:blood / Q000378:metabolism* / Q000652:urine; D001768:Blister / Q000188:drug therapy* / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D015242:Ofloxacin; D010078:Oxazines / Q000009:adverse effects / Q000378:metabolism*
D000890:Anti-Infective Agents; D010078:Oxazines; D015242:Ofloxacin