Vascular and secretory effect of adrenoceptor agonists and peptides in the nose.
With two methods which in cats simultaneously recorded changes of blood flow through the mucosa of a nasal cavity and changes of the nasal patency in the same cavity, it was found that alpha-adrenoceptor agonists and the peptide, angiotensin constricted both the resistance and the capacitance vessels. Beta-adrenoceptor agonists and the peptide VIP dilated the vessels. Further, a filter paper method in dogs demonstrated that a large increase in nasal secretion was obtained with alpha-adrenoceptor stimulation in combination with methacholine, more than that with methacholine alone. Beta-adrenoceptor agonists seem to elicit a very scanty secretion. The peptide, substance P was also found to evoke a nasal secretion.
D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D002417:Cattle; D004087:Dihydroergotamine / Q000494:pharmacology*; D004553:Electric Conductivity; D009297:Nasal Mucosa / Q000098:blood supply* / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology*; D009666:Nose / Q000098:blood supply*; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*
D011941:Receptors, Adrenergic; D004087:Dihydroergotamine; D009638:Norepinephrine