Schizophrenic disorders and HLA-DR antigens.
HLA-A, -B, and -DR antigens, including supertypic specificities (MT antigens), were studied in Japanese schizophrenic patients. Although frequencies of HLA-A, -B, and MT antigens did not differ significantly between the schizophrenic patients and controls, the frequency of DRw8 in DR locus showed a statistically significant increase in the patients. The authors conclude that DRw8 is a genetic marker of susceptibility to schizophrenia. Inconsistencies in previous reports of antigens could be resolved by examination of the DR locus.
D000293:Adolescent; D000328:Adult; D044466:Asian People; D005260:Female; D005819:Genetic Markers; D006680:HLA Antigens / Q000032:analysis; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012559:Schizophrenia / Q000235:genetics*
D005819:Genetic Markers; D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II