[Oncogene activation in the leukemias].
Retroviral oncogenes are derived in evolution from normal cellular genes termed proto-oncogenes. This discovery has prompted the question whether human tumor cells show alteration of proto-oncogenes. Alteration found in leukemias (gene amplification, translocation and point mutation) are briefly discussed. The genes termed myc, abl, ras are involved. A case of acute myeloblastic leukemia with a point mutation in the N-ras gene is briefly discussed.
D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000503:physiopathology; D009154:Mutation; D009857:Oncogenes; D014170:Transformation, Genetic; D014178:Translocation, Genetic
Onkogen-Aktivierung bei Leukämien.