Biological and psychological aspects of a case of Gilles de la Tourette's syndrome.
The case of a 12-year-old girl with Gilles de la Tourette's syndrome is presented, and the following factors are discussed: psychological aspects, urinary excretion of 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) and unconjugated amines, and CT scan findings. The most noticeable differences from normal controls seen in the urine studies were elevated levels of beta-phenylethylamine and the catecholamine metabolites normetanephrine, MHPG, and 3-methoxytyramine, and a decrease in 5-hydroxytryptamine. A CT scan revealed a slight increase in density in the caudate nuclei bilaterally; this was thought to be due to calcification.
D001927:Brain Diseases / Q000000981:diagnostic imaging; D002114:Calcinosis / Q000000981:diagnostic imaging; D002421:Caudate Nucleus / Q000000981:diagnostic imaging; D002648:Child; D004298:Dopamine / Q000652:urine; D005260:Female; D006801:Humans; D008734:Methoxyhydroxyphenylglycol / Q000652:urine; D009647:Normetanephrine / Q000652:urine; D010627:Phenethylamines / Q000652:urine; D012701:Serotonin / Q000652:urine; D014057:Tomography, X-Ray Computed; D005879:Tourette Syndrome / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000652:urine
D010627:Phenethylamines; D009647:Normetanephrine; D012701:Serotonin; D008734:Methoxyhydroxyphenylglycol; D004298:Dopamine