Novel reciprocal translocation between chromosomes 8 and 9 found in a patient with myeloproliferative disorder.
A reciprocal translocation between the short arm of chromosome 8 and the long arm of chromosome 9 is described. What appears to be a balanced translocation with breakage and reunion at bands 8p11 and 9q34 has not to our knowledge been previously observed. The abnormality is shown to be an acquired characteristic and was found in a patient with a myeloproliferative disorder whose clinical and laboratory findings were also compatible with Ph1-negative chronic granulocytic leukemia.
D000368:Aged; D002871:Chromosome Banding; D002904:Chromosomes, Human, 21-22 and Y; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000235:genetics*; D009196:Myeloproliferative Disorders / Q000235:genetics*; D014178:Translocation, Genetic