The effects of dipyridamole on TXA2 formation by horse platelet microsomes.
The effects of dipyridamole on thromboxane A2 formation by horse platelet microsomes were studied in comparison with those of imidazole, a prototype inhibitor of TXA2 synthetase and nifedipine, a calcium antagonistic vasodilator. Thromboxane A2 was synthesized by incubating PGH2 with horse platelet microsomes and was assayed on the superfused rabbit aorta. Dipyridamole induced as strong an inhibition of TXA2 synthesis as imidazole, while nifedipine was without effects. The possible beneficial clinical outcomes of this effect of dipyridamole are discussed.
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D004176:Dipyridamole / Q000494:pharmacology*; D006736:Horses; D007093:Imidazoles / Q000494:pharmacology; D066298:In Vitro Techniques; D008861:Microsomes / Q000378:metabolism*; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D009543:Nifedipine / Q000494:pharmacology; D013928:Thromboxane A2 / Q000096:biosynthesis*; D013931:Thromboxanes / Q000096:biosynthesis*; D014665:Vasodilator Agents / Q000494:pharmacology
D007093:Imidazoles; D013931:Thromboxanes; D014665:Vasodilator Agents; D013928:Thromboxane A2; D004176:Dipyridamole; C029899:imidazole; D009543:Nifedipine