Acinic cell carcinoma arising in the glossopalatine glands: a report of two cases with electron microscopic observations.
Two cases of acinic cell carcinoma arising in the glossopalatine glands were examined with the electron microscope by means of conventional thin sectioning and freeze-fracturing. Light and electron microscopic observation revealed that the tumors consisted of three types of cells: serous-type, ductlike, and vacuolated cells. Serous-type cells had numerous secretory granules, some of which were discharged into the intercellular spaces. Ductlike cells were smaller, usually lacked secretory granules, and were similar to intercalated duct cells. Vacuolated cells had electron-opaque vacuoles in the cytoplasm. Our findings supported the hypothesis that acinic cell carcinoma may represent a neoplasm of multipotential duct cells which have differentiated mainly into granulated serous cells. Freeze-fracture images of this tumor revealed that tight junctions were composed of ten or more interlinked strands with elongation of basal frontier strands. These findings suggested that the junctional morphology of the tumor resembled that of developing salivary glands and was associated with the degree of cellular differentiation.
D002277:Carcinoma / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D005614:Freeze Fracturing; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D010157:Palatal Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D012468:Salivary Gland Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D012469:Salivary Glands / Q000473:pathology*; D012470:Salivary Glands, Minor / Q000473:pathology* / Q000648:ultrastructure