[Effect of quinine on methamphetamine-induced anorexia].
Two experiments were done to examine the effect of quinine (Q) on methamphetamine (MA)-induced anorexia in rats. They were fasted throughout (water allowed ad libitum) except for a period of 6 hr (10:00-16:00) every day when powder food was offered. In the first experiment, the drug-admixed food (DAF) method was used for testing the effect of MA in combination with Q and MA alone on food consumption and the growth curve. However, the possibility exists that MA plus Q-admixed food increases the aversive reaction. Considering this possibility, we used the injection method in the second experiment. Rats received Q orally by a stomach tube and MA by subcutaneous injection. The injection was made 30 min before the presentation of food. In the DAF method, food consumption and weight of the MA and MA plus Q groups were inhibited. The inhibitions of the MA plus Q group were more potent than that of the MA group. In the injection method, the inhibitions of food consumption and growth curve in the MA plus Q group were significantly different from that of the MA group and were dose-dependent on MA. Tolerance to MA, as index of MA- induced anorexia, developed rapidly in the injection method, while tolerance to MA in the DAF method did not develop during the experiment. These results indicate that Q can markedly potentiate MA- induced anorexia.
D000284:Administration, Oral; D000818:Animals; D000855:Anorexia / Q000139:chemically induced*; D004357:Drug Synergism; D001068:Feeding and Eating Disorders / Q000139:chemically induced*; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage / Q000633:toxicity*; D011803:Quinine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D008694:Methamphetamine; D011803:Quinine