Bacterial contamination and the "toxicity" of materials to the exposed pulp.
The role of bacterial contamination in the toxicity to the pulp of a number of metallic salts was investigated. These had been tested as pulp-capping agents in previous studies involving 228 exposed rat molars. Material from the previous investigations was stained to demonstrate bacteria. This revealed bacteria in necrotic pulp tissue and/or the cavity-restoration interface in approximately 60% of the specimens. The presence of bacteria appeared to be related to pulpal inflammation, necrosis, and failure of calcific repair.
D000818:Animals; D018407:Bacterial Physiological Phenomena; D003782:Dental Pulp / Q000187:drug effects*; D003785:Dental Pulp Capping; D003788:Dental Pulp Diseases / Q000209:etiology* / Q000382:microbiology; D008670:Metals / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344
D008670:Metals