Erythroleukemia (K562) cells contain a functional beta-globin gene.
K562 cells are human erythroid cells that synthesize embryonic and fetal globins but not adult beta-globin. A cloned beta-globin gene was isolated from K562 cells and transfected into HeLa cells. The RNA transcripts produced were comparable in both amount and size to those obtained with a normal beta-globin gene.
D003001:Cloning, Molecular; D005796:Genes; D005914:Globins / Q000235:genetics*; D006367:HeLa Cells / Q000378:metabolism; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000235:genetics*; D013489:Suppression, Genetic; D014158:Transcription, Genetic; D014162:Transfection
D005914:Globins