[Blast cell differentiation of a continuous human leukemia line as affected by dimethyl sulfoxide].
The human blast cells line L-101 isolated from blood leukocytes of the patient with the cutaneous erythromyeloleukemia in the media with dimethyl-sulfoxide (DMSO) and maintained by permanent cultivation stimulate myeloid differentiation of this cells. The number of differentiated cells depends on DMSO concentration. Maximum of differentiated cells (up to 75%) have exposed on the 6th day of incubation with 0,75% DMSO. The cell line L-101 is a suitable model for investigation of myeloid differentiation.
D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002478:Cells, Cultured; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000473:pathology*; D007962:Leukocytes / Q000187:drug effects*; D013997:Time Factors
D004121:Dimethyl Sulfoxide
Differentsirovka blastnykh kletok perevivaemoĭ linii leĭkoza cheloveka pod deĭstviem dimetilsul'foksida.