Use of an MMPI scale to predict antidepressant response to lithium.
Previous research has indicated that a subset of Minnesota Multiphasic Personality Inventory (MMPI) items may be able to predict antidepressant treatment response to lithium. Twenty-one patients with major depressive disorder were assigned to treatment with lithium based on this MMPI lithium response scale. Twenty lithium-assigned patients completed the 4-week trial. Sixty percent of these patients showed a 50% reduction in Hamilton depression scores. This response rate is similar to results obtained in studies using no selection criteria in the treatment of depression with lithium.
D000328:Adult; D000639:Amitriptyline / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000188:drug therapy* / Q000523:psychology; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D003891:Desipramine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008094:Lithium / Q000627:therapeutic use*; D008950:MMPI; D008297:Male; D011379:Prognosis
D000639:Amitriptyline; D008094:Lithium; D003891:Desipramine