Desensitization to experimental asthma with 48/80.
The mast cell disintegrating histamine releaser, compound 48/80, given daily for 5 days by aerosol to guinea pigs produced relative resistance to 48/80 induced asthma, but not to histamine induced asthma. After 3 days of rest, sensitivity to the respiratory effects of 48/80 returned to baseline level. It was thought that the effects observed were due to depletion of pulmonary mast cells or their asthma mediators and regeneration after a period of rest.
D000336:Aerosols; D000818:Animals; D001249:Asthma / Q000139:chemically induced / Q000517:prevention & control*; D004361:Drug Tolerance; D005260:Female; D006168:Guinea Pigs; D006632:Histamine; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology; D003189:p-Methoxy-N-methylphenethylamine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D000336:Aerosols; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine