Ultrastructural changes in the cementoblasts of rat molars after injection of vincristine.
Cytological changes in the cementoblasts of rats treated with vincristine were investigated. Accumulation of secretion granules indicated a disturbed secretory mechanism in the cells. Conspicuous dilation of the endoplasmic reticulum suggested disturbance in the transport of substances from the rough endoplasmic reticulum to the Golgi elements. These disturbances were interpreted to be a result of disruption of microtubules.
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects; D003593:Cytoplasm / Q000187:drug effects; D003594:Cytoplasmic Granules / Q000187:drug effects; D003739:Dental Cementum / Q000166:cytology* / Q000187:drug effects / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000187:drug effects; D008297:Male; D008963:Molar; D051381:Rats; D011919:Rats, Inbred Strains; D014750:Vincristine / Q000494:pharmacology*
D014750:Vincristine