Different blood pressure responses to diuretic treatment in normotensive subjects with and without a family history of hypertension.
The possibility that the familial background for hypertension may influence the blood pressure response to diuretic treatment was evaluated in 14 normotensive subjects with negative and 14 normotensive subjects with positive family history of hypertension. Under control conditions, blood pressure, heart rate, body weight, urinary sodium and potassium, plasma sodium, potassium, creatinine, norepinephrine, epinephrine, renin and aldosterone levels did not differ between the two study groups. Each subject received chlorthalidone, 100 mg/day, or indapamide, 2.5 mg/day for eight weeks. Compared with control values, blood pressure was decreased during diuretic treatment in subjects with positive (P less than 0.05), but not in those with negative family history for hypertension. Diuretic-induced decreases in plasma potassium (P less than 0.005), increases in plasma renin activity and aldosterone (P less than 0.005), and a tendency towards higher plasma norepinephrine levels were not different between the two study groups. These findings suggest that the familial background of hypertension may, at least in part, determine the blood pressure response to diuretic treatment.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D002752:Chlorthalidone / Q000494:pharmacology*; D004232:Diuretics / Q000494:pharmacology*; D004837:Epinephrine / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000235:genetics*; D007190:Indapamide / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000097:blood; D011188:Potassium / Q000097:blood / Q000652:urine; D012016:Reference Values; D012964:Sodium / Q000097:blood / Q000652:urine
D004232:Diuretics; D012964:Sodium; D007190:Indapamide; D002752:Chlorthalidone; D011188:Potassium; D009638:Norepinephrine; D004837:Epinephrine