Chronic myelocytic leukemia with marked myelofibrosis and osteosclerosis.
An autopsy case of a 50 years old woman who manifested chronic myelocytic leukemia (CML) with secondary myelofibrosis (SMF) is reported. The interesting point of this case was a marked diffuse myelofibrosis (MF) with osteosclerosis, so that it was difficult to make a diagnosis of either CML or idiopathic myelofibrosis (IMF), but both clinical and histological findings supported the diagnosis of CML with SMF. Her long term busulfan therapy was suspected as being the cause of this severe MF. The relationship of CML and IMF was also discussed.
D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D007951:Leukemia, Myeloid / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008875:Middle Aged; D010026:Osteosclerosis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D055728:Primary Myelofibrosis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D013154:Spleen / Q000473:pathology