Dimethyl sulfoxide alteration of collagen.
In vitro incubation of human scar in our laboratory with 99% DMSO demonstrated, by electron microscopy, the disruption of the collagen fibers. This may prove to be a useful preparatory step for selective enzymatic assault upon exuberant or undesirable scar tissue in the clinical setting. Further study of this concept is planned.
D003094:Collagen / Q000378:metabolism*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008854:Microscopy, Electron
D003094:Collagen; D004121:Dimethyl Sulfoxide