Immunoelectronmicroscopic demonstration of surface tumor antigen Ca 125.
Tissue from a serous cystadenocarcinoma of the ovary was incubated with a monoclonal antibody, OC 125, which reacts with a surface tumor antigen in serous, endometrioid, and some clear cell carcinomas of the ovary. Electron microscopic preparation demonstrated the surface nature of the antigen. It is seen as a linear electron-dense deposit that extends onto villous surfaces. It is in some areas focally discontinuous. No other cell structures reacted with the antibody.
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D000951:Antigens, Neoplasm / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate; D002462:Cell Membrane / Q000648:ultrastructure; D003536:Cystadenocarcinoma / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D008854:Microscopy, Electron; D008871:Microvilli / Q000648:ultrastructure; D010051:Ovarian Neoplasms / Q000648:ultrastructure*
D000911:Antibodies, Monoclonal; D000936:Antigen-Antibody Complex; D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate