Heterogeneity of 5-hydroxytryptamine receptors in the rat uterus and stomach strip.
Experiments were performed using the rat isolated uterus and the rat stomach strip to investigate the effects of 5-hydroxytryptamine (5-HT) on 5-HT receptors in the presence of different antagonists. Amitriptyline, methysergide and trazodone were used to antagonize the response to 5-HT in these tissues. The pA2 value for amitriptyline with 5-HT as the agonist was estimated from the Schild plot analysis and found to differ significantly (P less than 0.05) in the stomach strip (6.36) from that in the isolated uterus (9.06). A similar difference was found using trazodone; here the pA2 value was 6.74 in the stomach strip and 8.49 in the isolated uterus. These results indicate a difference between the two tissues. This difference is discussed in terms of heterogeneity of 5-HT receptors.
D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D009928:Organ Specificity; D051381:Rats; D011985:Receptors, Serotonin / Q000145:classification* / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology; D013270:Stomach / Q000187:drug effects; D014196:Trazodone / Q000494:pharmacology; D014590:Uterine Contraction / Q000187:drug effects
D011985:Receptors, Serotonin; D000639:Amitriptyline; D012701:Serotonin; D008784:Methysergide; D014196:Trazodone