[N-Formimidoyl-thienamycin in Animal Studies].
The beta-lactam antibiotic thienamycin is rather unstable and is metabolized in man by renal dehydropeptidase-I. The derivatives of the antibiotic, especially N-formimidoyl-thienamycin (MK-0787) are reported to be more resistant. The antibacterial activity of N-formimidoyl-thienamycin was tested by means of the infection- and therapy model of the acute, occlusive pyelonephritis in rats. Cefotaxime was used as control agent. Even with a low dosage a clear anti-bacterial activity was proved with the E. coli- as well as especially with the Pseudomonas pyelonephritis. In our tests N-formimidoyl-thienamycin was more potent than cefotaxime.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000652:urine; D001419:Bacteria / Q000187:drug effects; D005260:Female; D015378:Imipenem; D007700:Kinetics; D051381:Rats; D011919:Rats, Inbred Strains; D013845:Thienamycins / Q000378:metabolism / Q000494:pharmacology* / Q000652:urine
D000900:Anti-Bacterial Agents; D013845:Thienamycins; D015378:Imipenem
N-Formimidoyl-thienamycin im Tierversuch.