Possible role of glutathione in the antitumor effect of a copper-containing synthetic superoxide dismutase in mice.
The effect of glutathione and a glutathione reductase inhibitor on the antitumor effect of Cu(II)(3,5-diisopropylsalicylate)2 (CuDIPS) was studied. CuDIPS is a low-molecular-weight copper coordination compound that exhibits superoxide dismutase-like activity. CuDIPS had antitumor activity against intraperitoneal Ehrlich ascites carcinoma in Swiss mice. A single ip injection of glutathione partially eliminated the antitumor effect of CuDIPS, whereas a single ip injection of 1,3-bis(2-chloroethyl)-1-nitrosourea enhanced the antitumor effect of CuDIPS. These results are consistent with the hypothesis that CuDIPS exerts part of its antitumor effect by producing H2O2.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001835:Body Weight; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D055598:Chemical Phenomena; D002621:Chemistry; D005978:Glutathione / Q000494:pharmacology*; D005980:Glutathione Reductase / Q000037:antagonists & inhibitors; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D012459:Salicylates / Q000627:therapeutic use*; D013482:Superoxide Dismutase / Q000627:therapeutic use*; D013997:Time Factors
D000970:Antineoplastic Agents; D012459:Salicylates; C030865:copper bis(3,5-diisopropylsalicylate); D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005978:Glutathione