Interferon induces pulmonary cysts in A2G mice.
Suckling A2G mice were treated for the first week of life with either partially purified or electrophoretically pure mouse alpha/beta interferon. All mice subsequently developed multiple large pulmonary cysts. The lesions were never found in interferon-treated Swiss mice and only very infrequently in interferon-treated BALB/c or F1 Swiss/A2G mice. These observations show that a brief exposure of suckling A2G mice to alpha/beta interferon can result in a severe disease that is determined by the mouse genotype.
D000818:Animals; D003560:Cysts / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D007370:Interferon Type I / Q000633:toxicity*; D008171:Lung Diseases / Q000139:chemically induced* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D013045:Species Specificity
D007370:Interferon Type I