Appearance of a new nucleosomal protein during differentiation of human leukemia (HL-60) cells.
A 60-kilodalton protein was identified in chromatin digested by micrococcal nuclease during retinoic acid-induced differentiation of human leukemia (HL-60) cells to mature-like granulocytes. The protein was not detected in a retinoic acid-resistant variant of the HL-60 cell line treated with retinoic acid, in HL-60 cells induced with dimethyl sulfoxide, or in normal human granulocytes. This protein may have an important role in the regulation of retinoic acid-induced leukemic cell differentiation.
D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D002499:Centrifugation, Density Gradient; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004591:Electrophoresis, Polyacrylamide Gel; D006098:Granulocytes / Q000378:metabolism; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism*; D009363:Neoplasm Proteins / Q000302:isolation & purification*; D009707:Nucleosomes / Q000378:metabolism*; D014212:Tretinoin / Q000494:pharmacology
D009363:Neoplasm Proteins; D009707:Nucleosomes; D014212:Tretinoin; D004121:Dimethyl Sulfoxide