Penetration of cefotetan into serum, myometrium, endometrium and salpinges.
24 patients received an intravenous 5-min bolus injection of 2 g cefotetan at various times prior to abdominal or vaginal hysterectomy. Cefotetan concentrations in salpinges were significantly higher than in myometrium and endometrium. Tissue concentrations of 16 micrograms/g could be attained for at least 5 h. At this concentration, 90% of most aerobic and anaerobic bacteria causing genital tract infections are inhibited.
D015313:Cefotetan; D002513:Cephamycins / Q000097:blood / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism; D005187:Fallopian Tubes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007275:Injections, Intravenous; D007700:Kinetics; D008875:Middle Aged; D009215:Myometrium / Q000378:metabolism; D011292:Premedication; D014599:Uterus / Q000378:metabolism*
D002513:Cephamycins; D015313:Cefotetan