The role of dental restorative metals in the pathogenesis of oral lichen planus.
Twenty-four subjects with oral lichen planus and twelve control subjects without oral mucosal disease were patch tested with dental restorative metals and selected metallic salts. Twenty-one percent of the lichen planus population exhibited a positive skin response to one or more challenge materials, as compared to 8% of the control population. It is concluded that oral lichen planus subjects show a higher correlation with delayed hypersensitivity to dental metals than a control population; however, a cause-and-effect relationship cannot be substantiated.
D000328:Adult; D000368:Aged; D003722:Dental Alloys / Q000009:adverse effects; D003723:Dental Amalgam / Q000009:adverse effects; D003764:Dental Materials / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology; D008010:Lichen Planus / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000209:etiology*; D010328:Patch Tests
D003722:Dental Alloys; D003764:Dental Materials; D003723:Dental Amalgam