Effects of salmon calcitonin on growth of teeth and on extraction socket healing in young rats.
The influence of salmon calcitonin on the growth of teeth and alveolar bone, and on the healing of alveolar sockets has been studied in young male rats. The experimental animals received daily injections of salmon calcitonin 0.5 MRC-U/kg body weight, whereas the control group received the vehicle. The rats were sacrificed at 14 and 28 days after the tooth extractions. Salmon calcitonin had no effect on the dry weight, calcium concentration and mineralization of the maxillary molars and the alveolar bone. Neither were there any significant effects of the hormone on the healing alveolar sockets. All sockets were healed after 4 weeks. The mineralization rate of molar teeth was only a quarter of that of tibiae, which was used as a reference.
D000539:Alveolar Process / Q000187:drug effects / Q000254:growth & development / Q000502:physiology*; D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014070:Tooth / Q000187:drug effects / Q000254:growth & development*; D014074:Tooth Calcification / Q000187:drug effects; D014081:Tooth Extraction; D014945:Wound Healing / Q000187:drug effects
D002116:Calcitonin