The reaction of rat connective tissue to polyethylene tube implants filled with Hydron or gutta-percha.
A subcutaneous tube implant study was conducted on adult Sprague-Dawley rats. Polyethylene tubes sealed at one end were filled flush to the open end with Hydron or gutta-percha and sealer. These implants were immediately placed into dorsal subcutaneous connective tissue for periods ranging from three weeks to 6 months. Tubes filled with Hydron demonstrated expansion and resorption of material with its distribution into connective tissue. A moderately thick connective tissue capsule containing macrophages formed at the tissue-Hydron interface. Amorphous calcific deposits were localized within Hydron, being most dense at the Hydron--tissue interface. Tubes filled with gutta-percha and sealer demonstrated thinner connective tissue capsule formation, with little or no distribution or resorption of material. A mild lymphocyte response was noted within the capsule adjacent to the gutta-percha.
D000818:Animals; D001672:Biocompatible Materials; D003238:Connective Tissue / Q000033:anatomy & histology; D006171:Gutta-Percha; D020100:Hydrogels; D011095:Polyethylenes; D011102:Polyhydroxyethyl Methacrylate / Q000031:analogs & derivatives; D011109:Polymethacrylic Acids; D019736:Prostheses and Implants; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000033:anatomy & histology
D001672:Biocompatible Materials; D020100:Hydrogels; D011095:Polyethylenes; D011109:Polymethacrylic Acids; C000257:polyhydroxyethyl methacrylate hydrogels; D011102:Polyhydroxyethyl Methacrylate; D006171:Gutta-Percha