Platelet phenolsulphotransferase activity in Parkinson's disease.
Mean platelet phenolsulphotransferase activity was significantly increased in L-dopa-treated parkinsonian patients compared with controls. The degree of rise was associated with dose of and duration of treatment with L-dopa and may thus represent an adaptive increase to circulating dopamine. Alternatively, the increase may reflect changes supervening with duration of illness.
D000367:Age Factors; D015239:Arylsulfotransferase; D001792:Blood Platelets / Q000201:enzymology*; D002230:Carbidopa / Q000008:administration & dosage; D004338:Drug Combinations; D006801:Humans; D007980:Levodopa / Q000008:administration & dosage; D008995:Monoamine Oxidase / Q000097:blood; D010300:Parkinson Disease / Q000097:blood* / Q000188:drug therapy; D013466:Sulfurtransferases / Q000097:blood*; D013997:Time Factors
D004338:Drug Combinations; D007980:Levodopa; D008995:Monoamine Oxidase; D013466:Sulfurtransferases; D015239:Arylsulfotransferase; D002230:Carbidopa