[What have morphology and cytochemistry contributed to the diagnosis and treatment of acute lymphatic leukemia of childhood?].
Correlations between morphological and cytochemical classification and treatment results in 200 children with ALL (diagnosed from 1964 to 1980) resulted in small, insignificant differences: FAB-L2 morphology, and undifferentiated cytochemistry resulted in slightly worse remission or survival duration. A significant difference emerged between the best group (FAB-L2 and PAS-positivity) and the worst (FAB-L2 and undifferentiated cytochemistry). All immunologically examined blasts with strong acid phosphatase positivity showed T-cell markers, but not all those with T-cell markers were phosphatase positive. On the whole, the morphologic/cytochemical classification used here is not satisfactory and has declined significantly in importance due to the much improved treatment results since 1970.
D000135:Acid Phosphatase; D002471:Cell Transformation, Neoplastic / Q000378:metabolism / Q000473:pathology*; D002648:Child; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007945:Leukemia, Lymphoid / Q000097:blood* / Q000145:classification / Q000188:drug therapy; D008297:Male; D009283:Naphthol AS D Esterase; D010503:Periodic Acid-Schiff Reaction; D011379:Prognosis
D009283:Naphthol AS D Esterase; D000135:Acid Phosphatase
Was haben Morphologie und Zytochemie zur Diagnostik und Behandlung der akuten lymphatischen Leukämie im Kindesalter beigetragen?