Gastrointestinal and cardiovascular effects of the prostaglandin analogue Hoe 260.
Hoe 260 is a long-lasting and potent antisecretory and cytoprotective prostaglandin E2-analogue, having a favourable split between therapeutic gastric effects, effect on blood pressure and intestinal side effects; this compound could be a promising drug in ulcer therapy. (formula; see text)
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D015232:Dinoprostone / Q000031:analogs & derivatives; D004285:Dogs; D005744:Gastric Acid / Q000378:metabolism*; D005750:Gastric Juice / Q000187:drug effects; D007700:Kinetics; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic; C043870:HOE 260; D015232:Dinoprostone