Rapid quantitative determination of seven anthracyclines and their hydroxy metabolites in body fluids.
A reversed-phase high-performance liquid chromatographic method is described for the determination of seven anthracycline analogues and their hydroxy metabolites. The method is suitable for analysis of 30 plasma samples a day. The detection limit is 0.5 ng/ml for all compounds. Examples of the pharmacokinetics of adriamycin and carminomycin in man are shown.
D000818:Animals; D000903:Antibiotics, Antineoplastic; D002360:Carubicin / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004285:Dogs; D004317:Doxorubicin / Q000378:metabolism; D004355:Drug Stability; D006801:Humans; D006900:Hydroxylation; D007700:Kinetics; D009279:Naphthacenes / Q000032:analysis / Q000097:blood / Q000652:urine; D013050:Spectrometry, Fluorescence / Q000379:methods
D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; D004317:Doxorubicin; D002360:Carubicin