Extended haplotypes of chromosome 6 in adult rheumatoid arthritis.
In 46 patients with rheumatoid arthritis (RA) the allele C4B*3 occurred in 6 patients, while among 350 normal controls, it occurred 6 times (P less than 0.00002). Among 9 white and 1 black families, each of which had 2 or more members with RA, there were 36 haplotypes associated with RA. An extended haplotype (specific HLA-B, DR, complotype haplotypes in significant linkage disequilibrium) containing C4B*3: HLA-B15, DR4, BF*S, C2*C, C4A*3, C4B*3, was found twice (P less than 0.001) among whites with the disease-associated chromosomes.
D000328:Adult; D000483:Alleles; D001172:Arthritis, Rheumatoid / Q000235:genetics*; D044383:Black People; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D003165:Complement System Proteins / Q000235:genetics; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics; D015235:HLA-B Antigens; D006238:Haploidy; D006801:Humans; D008285:Major Histocompatibility Complex; D044465:White People
D006680:HLA Antigens; D015235:HLA-B Antigens; D003165:Complement System Proteins