Experimental studies on the possible combined chemotherapy to neoplasms with Fluosol-DA infusion.
Administration of Fluosol DA with oxygen elevated the tissue p02 in tumors primarily due to the increased local blood flow and to the higher oxygen content of Fluosol-DA. The elevated tissue p02 enhanced the tumor's sensitivity to the cytotoxic effect of some anticancer drugs.
D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage*; D004338:Drug Combinations / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005466:Fluorocarbons / Q000008:administration & dosage*; D006895:Hydroxyethyl Starch Derivatives; D008297:Male; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D015376:Nimustine; D009607:Nitrosourea Compounds / Q000008:administration & dosage; D010100:Oxygen / Q000008:administration & dosage; D010101:Oxygen Consumption; D051381:Rats
D001802:Blood Substitutes; D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; D009607:Nitrosourea Compounds; D015376:Nimustine; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; D010100:Oxygen