The effect of fluoride on the electrophoretic patterns of developing rat molar enamel.
Rat pups were given 4 micrograms F/g X day from 3-7 days of age by intraperitoneal injection of NaF. Demineralized enamel matrix from 8- to 15-day-old rats was subjected to SDS-polyacrylamide gel electrophoresis. The results showed that there was a decrease in the relative proportion of high molecular-weight proteins with maturation. Enamel formed in the presence of F showed more abundant low molecular-weight proteins in the secretory stage and a delay in the decrease of high molecular-weight proteins with maturation. These observations indicate that F may influence the assembly or dis-assembly of early enamel proteins.
D000818:Animals; D003743:Dental Enamel / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D003746:Dental Enamel Proteins / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D008970:Molecular Weight; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000494:pharmacology*
D003746:Dental Enamel Proteins; D012969:Sodium Fluoride