Parotid saliva agglutinins for sheep erythrocytes as a measure of ongoing inflammation in periodontal disease.
The level of parotid saliva agglutinins to sheep erythrocytes (PSAE) may be directly related to the severity of ongoing inflammation. PSAE were titrated in a population of 19 individuals with no clinical evidence of gingivitis or periodontitis. In these normal individuals PSAE were detected at an average salivary dilution of 1:8. However, 31 patients receiving treatment for periodontitis had PSAE at an average dilution of 1:26. Furthermore, the parotid saliva of those periodontal patients had significantly higher IgA and protein concentrations than the healthy group. The salivary flow rate and the IgA to protein ratio were similar in both groups. The elevated titer of PSAE may be due in part to heterogenic stimulation of B cells in periodontal tissues and therefore may be related to the rate of the ongoing inflammatory disease process.
D000371:Agglutination; D000373:Agglutinins / Q000032:analysis*; D000818:Animals; D002848:Chromatography, DEAE-Cellulose; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D010306:Parotid Gland / Q000378:metabolism; D010510:Periodontal Diseases / Q000276:immunology*; D012463:Saliva / Q000276:immunology; D012471:Salivary Proteins and Peptides / Q000032:analysis*; D012636:Secretory Rate; D012756:Sheep
D000373:Agglutinins; D007070:Immunoglobulin A; D012471:Salivary Proteins and Peptides