Effect of indomethacin on the growth of colon cancer cells in syngeneic rats.
A cell culture line has been established from a colonic tumor induced in a rat by dimethylhydrazine. Indomethacin had no effect on the growth of tumors induced in syngeneic rats by s.c. injection of this cell line. Neither indomethacin, nor prostaglandin E2 modify the growth of this established cell line in vitro or alter its destruction by endotoxin-activated macrophages. Indomethacin has been reported to suppress the growth of colonic tumors induced in rats by various carcinogenic drugs. The difference between these results obtained by others on chemically-induced colon cancer and the data we have obtained with a cell line derived from a similar cancer suggests that cancer cells in established culture may loose their sensitivity to prostaglandins, prostaglandin inhibitors or prostaglandin-dependent effector host cells.
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D003110:Colonic Neoplasms / Q000276:immunology / Q000503:physiopathology*; D015232:Dinoprostone; D004731:Endotoxins / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology*; D008262:Macrophage Activation / Q000187:drug effects; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D004731:Endotoxins; D011458:Prostaglandins E; D015232:Dinoprostone; D007213:Indomethacin