Effects of fibrinogen in vivo on dentine permeability in the dog.
Dentine permeability measurements were made each hour for 6 h in tooth cavities prepared in control dogs or dogs which had been pretreated with a purified fraction of snake venom to deplete their plasma of fibrinogen. The control dogs exhibited a progressive fall in dentine permeability (approximately 50 per cent reduction in 6 h); the permeability in the fibrinogen-depleted dogs only fell 15 per cent in 6 h. The results implicate plasma proteins, particularly high molecular-weight proteins such as fibrinogen, as agents which reduce dentine permeability in vivo.
D000818:Animals; D003804:Dentin / Q000378:metabolism; D003806:Dentin Permeability; D004285:Dogs; D005260:Female; D005340:Fibrinogen / Q000378:metabolism / Q000502:physiology*; D008297:Male; D014088:Tooth Permeability
D005340:Fibrinogen