Unusual translocations t(2;6) and t(?;22) in a child with acute myelocytic leukemia.
A 13-month-old female with middle and upper lobe pneumonia showed a high WBC count with 99% blasts. From hematologic studies the condition was diagnosed as acute myelocytic leukemia (AML). In spite of aggressive chemotherapy, the patient died. Unstimulated peripheral blood culture and bone marrow cells revealed a translocation between a chromosome #2 and #6. An interstitial segment of 2q had been translocated to 6p. A chromosome #22 was also abnormal, having acquired a dark band around the long arm.
D002869:Chromosome Aberrations / Q000235:genetics*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002900:Chromosomes, Human, 1-3; D002904:Chromosomes, Human, 21-22 and Y; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006801:Humans; D007223:Infant; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D014178:Translocation, Genetic