A high-resolution study of chromosome changes in a human prostatic carcinoma cell line (LNCaP).
A high-resolution study of chromosomal rearrangements in a human prostatic cancer cell line, LNCaP, has been performed. The cytogenetic analysis revealed a pseudodiploid karyotype and the presence of seven marker chromosomes resulting from five aberrational events. The analysis of four clones derived from the original line showed a near-tetraploid chromosome number and the presence of the same seven markers observed in the original line. This is the first complete description of karyotypic rearrangements in a prostatic cancer cell line.
D002460:Cell Line; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005819:Genetic Markers; D006801:Humans; D007621:Karyotyping; D008297:Male; D011003:Ploidies; D011471:Prostatic Neoplasms / Q000235:genetics*
D005819:Genetic Markers