Essential hypertension and membrane lithium transport in depressed patients.
Na+-Li+ countertransport activity in erythrocytes has previously been reported to be decreased in certain patients with mood disorders, but increased in essential hypertensives and possibly their first-degree relatives. The present investigation examines specific parameters of Na+-Li+ countertransport in relation to both affective disorder and essential hypertension. Depressed patients having a personal or family history of essential hypertension had significantly higher Vmax and fractional lithium release values than did other patients or control subjects. Values of K 1/2 did not differ among the groups. Essential hypertension in experimental subjects or their families may complicate attempts to study human erythrocyte (RBC) lithium transport in depressed patients.
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood*; D003866:Depressive Disorder / Q000097:blood*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007700:Kinetics; D008094:Lithium / Q000097:blood*; D008297:Male; D012964:Sodium / Q000097:blood
D008094:Lithium; D012964:Sodium