Stimulation of granulocyte functions in vitro by imipenem and the renal enzyme inhibitor MK 0791.
Imipenem and the renal enzyme inhibitor MK 0791 (dehydropeptidase-I) were tested separately and in a 1:1 combination to delineate their effects on granulocyte functioning. Each component, as well as the combination product, was found to increase granulocyte adherence and chemotaxis at therapeutic concentrations. Phagocytosis and chemiluminescence were not found to be significantly altered by any of the drug combinations.
D002448:Cell Adhesion / Q000187:drug effects; D002633:Chemotaxis / Q000187:drug effects; D015377:Cilastatin; D003521:Cyclopropanes / Q000494:pharmacology*; D004150:Dipeptidases / Q000037:antagonists & inhibitors*; D006098:Granulocytes / Q000187:drug effects*; D006801:Humans; D015378:Imipenem; D066298:In Vitro Techniques; D007668:Kidney / Q000201:enzymology*; D008163:Luminescent Measurements; D010587:Phagocytosis / Q000187:drug effects; D013845:Thienamycins / Q000494:pharmacology*
D003521:Cyclopropanes; D013845:Thienamycins; D015377:Cilastatin; D015378:Imipenem; D004150:Dipeptidases