Genome alteration during in vitro and in vivo aging: amplification of extrachromosomal circular DNA molecules containing a chromosomal sequence of variable repeat frequency.
D000328:Adult; D000368:Aged; D000375:Aging; D002478:Cells, Cultured; D002877:Chromosomes, Human / Q000502:physiology*; D004270:DNA, Circular / Q000235:genetics* / Q000302:isolation & purification; D005347:Fibroblasts / Q000502:physiology; D005784:Gene Amplification; D006801:Humans; D008214:Lymphocytes / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009693:Nucleic Acid Hybridization; D012879:Skin Physiological Phenomena
D004270:DNA, Circular