Interferon-induced changes in the susceptibility of murine and human lymphoma cells to natural cytotoxic lymphocytes.
Mouse YAC-1 and human K562 leukemic cells were treated in vitro with fibroblast interferon (IF) and tested for their susceptibility to NK effector lymphocytes. In both cases a decrease in target susceptibility was induced by the IF treatment. "Cold" competition experiments confirmed that loss or masking of NK target structures occurred in IF-pretreated cells. In fact, when radio-labeled untreated cells were used as targets, IF-pretreated leukemias produced inhibitory effects lower than those mediated by intact cells. However when IF-pretreated targets were used, cold cells either intact or preincubated with IF gave similar competitive effects. These data suggest that IF modulates differentially distinct subsets of NK target structures.
D000818:Animals; D002460:Cell Line; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000187:drug effects*; D004915:Leukemia, Erythroblastic, Acute / Q000276:immunology; D007942:Leukemia, Experimental / Q000276:immunology; D008223:Lymphoma / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
D007370:Interferon Type I