Masked Philadelphia chromosome due to the translocation (1q-;22q +) and small chromosome 19 in a case of acute leukemia.
The case of a 51-year-old female with acute myelomonocytic leukemia (AMMoL) and masked Philadelphia (Ph1) chromosome is reported. The Ph1 resulted from a translocation involving chromosomes 1 and 22, in which a segment of the long arm of one chromosome 1 (1q12----q25) was translocated to the long arm of one chromosome 22 at band 22q11. Additionally, a marker chromosome of unknown origin and deletion of the long arm of one chromosome 19 at band 19q12 were found. The literature on masked Ph1 chromosomes and changes of chromosomes 1 and 19 is briefly summarized.
D002872:Chromosome Deletion; D002900:Chromosomes, Human, 1-3; D002903:Chromosomes, Human, 19-20; D002904:Chromosomes, Human, 21-22 and Y; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008875:Middle Aged; D014178:Translocation, Genetic