HLA-linked SB antigens in Israel. Population study, analysis of homozygous typing cells and generation of local SB reagents.
In the present study we have investigated the HLA-SB antigen distribution in 65 unrelated Israeli Ashkenazim and non-Ashkenazim and in a panel of 18 local homozygous typing cells (HTC). Two locally derived SB reagents, anti-SB2 and SB3, were also studied. The HLA-SB allele frequencies in the Israeli sample ranged from 0.02 for SB1 to 0.47 for SB4 while SB5 was absent. SB3 had a higher frequency in non-Ashkenazim (0.11) as compared to Ashkenazim (0.06) but this difference was not significant. On the whole, the allele frequencies for the 5 HLA-SB antigens studied were in the range observed in non-Jewish Caucasoid populations with some minor variations. Two of eighteen local HTC's were found heterozygous for SB, demonstrating that homozygosity for HLA-A, B, C, D and DR does not indicate homozygosity for HLA-SB. The local anti-SB2 and SB3 typing reagents gave concordant results when compared with the NIH reference typing cells in population studies.
D005060:Europe / Q000208:ethnology; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D006682:HLA-DP Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D007518:Isoantibodies / Q000276:immunology; D007557:Israel; D007585:Jews; D008297:Male; D044465:White People
D006682:HLA-DP Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D007518:Isoantibodies