[Use of prolonged intravenous infusions of cisplatin in patients with malignant neoplasms].
11 patients with generalized forms of cancer received 14 courses of 120-hr non-stop intravenous infusions of 20-30 mg/m2/24 hrs of cis-diamminedichloroplatinum supplied by portable pumps (total dose--80-150 mg/m2). Apparent nausea and vomiting were observed only in 4 out of 14 treatment courses 28%. There was no nephrotoxic effect. Therapeutic effect was established in 6 cases of testicular teratocarcinoma. Complete response was obtained in 1 case and partial remission--in 1 case. The rate of 25 mg/m2/24 hrs (for 120 hrs) should be used in further studies of the effectiveness of intravenous infusions of cis-diamminedichloroplatinum.
D000328:Adult; D002945:Cisplatin / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007263:Infusions, Parenteral; D007674:Kidney Diseases / Q000139:chemically induced; D008297:Male; D009325:Nausea / Q000139:chemically induced; D009447:Neuroblastoma / Q000188:drug therapy; D012516:Osteosarcoma / Q000188:drug therapy; D013724:Teratoma / Q000188:drug therapy* / Q000556:secondary; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000556:secondary; D014839:Vomiting / Q000139:chemically induced
D002945:Cisplatin
Primenenie tsis-platiny (platidiama) putem dlitel'nykh vnutrivennykh infuziĭ u bol'nykh zlokachestvennymi zabolevaniiami.