In vitro antagonism between N-formimidoyl thienamycin and aztreonam, ticarcillin and ticarcillin/clavulanic acid.
One-hundred eighty-seven bacterial strains were tested by the two-disk-agar diffusion method for the interaction between N-formimidoyl thienamycin and aztreonam, ticarcillin and ticarcillin-clavulanic acid. An antagonism between N-formimidoyl thienamycin and the other 3 beta-lactams was noted in half of the evaluable tests, especially against Pseudomonas, Escherichia coli and Morganella.
D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors*; D001398:Aztreonam; D001419:Bacteria / Q000187:drug effects*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000037:antagonists & inhibitors*; D015378:Imipenem; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000037:antagonists & inhibitors*; D013845:Thienamycins / Q000494:pharmacology*; D013982:Ticarcillin / Q000037:antagonists & inhibitors*
D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D010406:Penicillins; D013845:Thienamycins; D019818:Clavulanic Acid; D015378:Imipenem; D013982:Ticarcillin; D001398:Aztreonam