The use of intravenous disopyramide for the conversion of supraventricular tachyarrhythmias.
A study of the efficacy of intravenous disopyramide in the conversion of supraventricular tachyarrhythmias to sinus rhythm was undertaken in a group of 23 patients with a variety of cardiological diagnoses. An intravenous bolus (2 mg/kg) followed, where appropriate, by an infusion (0.4 mg/kg) resulted in an overall conversion rate of 63% (43% in atrial fibrillation, 50% in atrial flutter, 89% in atrial tachycardias). Serious cardiotoxic side effects occurred in 15%. The study shows that such a regime is useful in a selected group of patients provided certain precautions are observed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D001281:Atrial Fibrillation / Q000188:drug therapy; D001282:Atrial Flutter / Q000188:drug therapy; D004206:Disopyramide / Q000008:administration & dosage* / Q000009:adverse effects; D004341:Drug Evaluation; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D013610:Tachycardia / Q000188:drug therapy*
D004206:Disopyramide