Biological activity of a fluorescent 12-O-tetradecanoyl-phorbol-13-acetate derivative.
A newly synthesized fluorescent TPA derivative, O-(N-dansylamino-3-tetradecanoyl)-12,O-acetyl-13-phorbol (Dansyl-TPA), inhibited metabolic cooperation of Chinese hamster V79 cells in culture and also the specific binding of [3H]phorbol dibutyrate to V79 cells. Dansyl-TPA should be a valuable tool for studying the cellular targets of TPA.
D000818:Animals; D006224:Cricetinae; D003412:Cricetulus; D003619:Dansyl Compounds / Q000494:pharmacology*; D005453:Fluorescence; D015240:Phorbol 12,13-Dibutyrate; D010703:Phorbol Esters / Q000378:metabolism; D010704:Phorbols / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000031:analogs & derivatives* / Q000494:pharmacology*
D003619:Dansyl Compounds; D010703:Phorbol Esters; D010704:Phorbols; D015240:Phorbol 12,13-Dibutyrate; C043670:O-(N-dansylamino-3-tetradecanoyl)-12,O-acetyl-13-phorbol; D013755:Tetradecanoylphorbol Acetate