Effect of allylisopropylacetamide and Sedormid on enzymes of steroid metabolism in rat liver.
Female rats, treated with allylisopropylacetamide (AIA) showed a marked decrease of hepatic NADH-5 alpha-reductase, NADPH-5 alpha-reductase, NAD+- and NADP+-3 alpha-hydroxysteroid dehydrogenase activities and an increase of the activity of NADH- and NADPH-5 beta-reductase and NAD+ and NADP+-3 beta-hydroxysteroid dehydrogenase. Administration of Sedormid decreased the activities of 5 alpha-reductases and 3 alpha-hydroxysteroid dehydrogenases (substrate, 5 alpha-dihydrotestosterone) and increased the activity of NADH-5 beta-reductase, whereas no effect was seen on NADPH-5 beta-reductase and 3 beta-hydroxysteroid dehydrogenase.
D000081:Acetamides / Q000494:pharmacology*; D000502:Allylisopropylacetamide / Q000494:pharmacology*; D000818:Animals; D042944:Cholestenone 5 alpha-Reductase; D005260:Female; D006913:Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D008862:Microsomes, Liver / Q000201:enzymology*; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D013256:Steroids / Q000378:metabolism; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology
D000081:Acetamides; D013256:Steroids; D009243:NAD; D000502:Allylisopropylacetamide; D009249:NADP; D014508:Urea; D010088:Oxidoreductases; D006913:Hydroxysteroid Dehydrogenases; D042944:Cholestenone 5 alpha-Reductase; C005700:apronalide