Biologic evaluation of a silver-copper-germanium dental casting alloy and a gold-germanium coating alloy.
An Ag-Cu-Ge alloy and an Au-Ge alloy were evaluated for their hemolytic effect on rabbit blood, cytotoxicity to alpha-L fibrosarcoma cells, and allergenic effect on guinea pigs. Neither alloy evoked a significant hemolytic response; cytotoxicity, and that of pure germanium, was no greater than that of ZOE cement; and, on the basis of the guinea pig response, the potential human allergenic response was considered to be Grade I (weak) and Grade II (mild), respectively.
D000818:Animals; D002478:Cells, Cultured / Q000187:drug effects; D003300:Copper; D003722:Dental Alloys / Q000633:toxicity; D005069:Evaluation Studies as Topic; D005857:Germanium; D006047:Gold Alloys; D006168:Guinea Pigs; D006461:Hemolysis; D006967:Hypersensitivity / Q000209:etiology; D011817:Rabbits; D012834:Silver
D003722:Dental Alloys; D006047:Gold Alloys; D005857:Germanium; D012834:Silver; D003300:Copper