Prepubertal periodontitis affecting the deciduous and permanent dentition in a patient with cyclic neutropenia. A case report and discussion.
Neutropenia is a transient or chronic blood disorder characterized by a decrease in the number of circulating polymorphonuclear leukocytes (PMNs). Neutrophils are a major cellular defense against infection, and depletion of these cells is potentially fatal. Stomatitis and gingivitis frequently are seen in patients with neutropenia. Therefore, the diagnosis of severe oral pathoses of obscure origin must include a differential white blood cell count. The importance of the dentist's role is dramatically illustrated in the rare case reported here, since the oral condition was the reason for this patient's definitive blood work-up. The report illustrates the importance of the laboratory assessment in dental patients with unusual periodontal destruction or other inexplicable oral changes.
D010520:Aggressive Periodontitis / Q000473:pathology*; D000380:Agranulocytosis / Q000473:pathology*; D001862:Bone Resorption / Q000473:pathology; D002648:Child; D003818:Dentition, Mixed; D005260:Female; D005891:Gingivitis / Q000473:pathology; D006801:Humans; D007958:Leukocyte Count; D008310:Malocclusion / Q000473:pathology; D009503:Neutropenia / Q000473:pathology*; D010507:Periodicity; D010510:Periodontal Diseases / Q000473:pathology*; D014094:Tooth, Deciduous / Q000473:pathology*