[Mechanisms of potentiating and prolonging the radioprotective effect of multicomponent compounds].
A study was made of the effect of mexamine, etiron and gutimine on the pattern of distribution of cystamine within the body and the rate of its conversion in tissues of albino mice. It was shown that the potentiation and prolongation of the radioprotective effect is based on the ability of the complex of these preparations to inhibit the conversion of the S-containing radioprotective agent.
D008735:5-Methoxytryptamine / Q000378:metabolism; D000818:Animals; D003538:Cystamine / Q000378:metabolism; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004357:Drug Synergism; D006164:Guanylthiourea / Q000378:metabolism; D007550:Isothiuronium / Q000031:analogs & derivatives / Q000378:metabolism; D008297:Male; D051379:Mice; D011837:Radiation-Protective Agents / Q000378:metabolism / Q000494:pharmacology*; D014018:Tissue Distribution
D003692:Delayed-Action Preparations; D004338:Drug Combinations; D011837:Radiation-Protective Agents; D007550:Isothiuronium; C007687:etiron; D008735:5-Methoxytryptamine; D006164:Guanylthiourea; D003538:Cystamine
Mekhanizmy potentsirovaniia i prolongirovaniia radiozashchitnogo éffekta mnogokomponentnykh retseptur.