Hypercholesterolemic and diabetic serum decrease LDL-degradation by cathepsin D from human arterial smooth muscle cells and fibroblasts.
D001055:Apolipoproteins B / Q000378:metabolism; D002402:Cathepsin D / Q000378:metabolism*; D002478:Cells, Cultured; D008078:Cholesterol, LDL / Q000378:metabolism; D003920:Diabetes Mellitus / Q000097:blood*; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D008077:Lipoproteins, LDL / Q000378:metabolism*; D009131:Muscle, Smooth, Vascular / Q000201:enzymology*
D001055:Apolipoproteins B; D008078:Cholesterol, LDL; D008077:Lipoproteins, LDL; D002402:Cathepsin D