Preoperative chemotherapy and surgical resection in the management of posterior paraspinal tumors. Report of three cases.
Three patients with posterior paravertebral tumors are presented to illustrate the value of preoperative chemotherapy prior to surgical resection. All three had massive tumors adjacent to the spine, extending over several vertebral segments, with myelographic evidence of epidural involvement in one patient. Tissue diagnosis by incisional biopsy confirmed the diagnosis of extraosseous osteogenic sarcoma in one, extraosseous Ewing's sarcoma in the second, and embryonal rhabdomyosarcoma in the third. All patients were treated with chemotherapy preoperatively. Marked regression in tumor size was noted, and surgical excision of the tumor along with involved segments of spine was easily accomplished. Histological examination following surgery revealed completely necrotic tumor in two patients. Preoperative chemotherapy for fully malignant tumors offers the following advantages: 1) extremely bulky and otherwise unresectable tumors can be reduced in size to enable complete surgical resection; 2) systemic chemotherapy is instituted earlier in the course of disease to prevent more effectively the appearance of metastases; and 3) the information gained regarding the sensitivity of the tumor to a particular chemotherapy regimen allows postoperative adjuvant chemotherapy to be used on a more rational basis.
D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D012516:Osteosarcoma / Q000188:drug therapy / Q000601:surgery*; D011292:Premedication; D012208:Rhabdomyosarcoma / Q000188:drug therapy / Q000601:surgery*; D012512:Sarcoma, Ewing / Q000188:drug therapy / Q000601:surgery*; D013125:Spinal Neoplasms / Q000188:drug therapy / Q000601:surgery*
D000970:Antineoplastic Agents