A mouthrinse which optimizes in vivo generation of hypothiocyanite.
We report here the properties of a mouthrinse which enhances one of the natural defense factors in human saliva, the salivary peroxidase system. Concentrations of the antimicrobial agent, the hypothiocyanite (OSCN-) ion, can be increased in vivo to bacteriostatic levels by use of a mouthrinse which is 4 mM (0.014%) in hydrogen peroxide and 1 mM (0.0097%) in potassium thiocyanate at pH 5.5. The volume of the rinse, the H2O2 concentrations, and the pH were shown to be determinants of the concentration of OSCN- generated by the rinse.
D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000494:pharmacology; D003773:Dental Plaque / Q000503:physiopathology; D006801:Humans; D006861:Hydrogen Peroxide / Q000008:administration & dosage / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D009067:Mouthwashes / Q000008:administration & dosage* / Q000494:pharmacology; D012463:Saliva / Q000032:analysis / Q000378:metabolism*; D013861:Thiocyanates / Q000032:analysis / Q000378:metabolism*
D000890:Anti-Infective Agents; D009067:Mouthwashes; D013861:Thiocyanates; C014607:hypothiocyanite ion; D006861:Hydrogen Peroxide