Metastatic periosteal osteosarcoma causing cardiac and renal failure.
The case of a 25-year-old man who had periosteal osteogenic sarcoma with intravascular metastases in unusual locations is reported. The patient presented with acute renal failure, unilateral pulmonary edema, functional mitral stenosis, and low cardiac output. After successful surgical removal of a left atrial metastasis with subsequent improvement in cardiac output, renal function improved only transiently and urinary output varied markedly. At autopsy, metastatic osteogenic sarcoma was discovered within the lumen of the abdominal aorta obstructing both renal arteries. The case is the first report of a neoplasm metastatic to the aorta causing intermittent bilateral renal arterial obstruction; it illustrates the diagnostic difficulties presented by intravascular metastatic disease.
D058186:Acute Kidney Injury / Q000209:etiology*; D000328:Adult; D001012:Aorta, Abdominal / Q000473:pathology*; D001859:Bone Neoplasms / Q000473:pathology*; D006333:Heart Failure / Q000209:etiology*; D006338:Heart Neoplasms / Q000556:secondary; D006801:Humans; D008297:Male; D012516:Osteosarcoma / Q000150:complications / Q000473:pathology / Q000556:secondary*; D010521:Periosteum