Investigation of porcine natural-killer cell activity with reference to African swine-fever virus infection.
The natural killing of the human myeloid leukaemia cell line by pig mononuclear cells was investigated in an 18 hr assay; the most active natural-killer (NK) effectors were those cells not adhering to nylon-wool columns or rosetting with sheep red blood cells. Mononuclear cells cultured in the presence of African swine-fever virus maintained NK activity. Pigs infected with African swine-fever virus exhibited a suppressed NK activity, possibly due to the sensitivity of NK cells to increased temperatures. The possible role of NK cells in recovery from African swine fever is discussed.
D000357:African Swine Fever / Q000276:immunology*; D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D015470:Leukemia, Myeloid, Acute / Q000276:immunology; D012397:Rosette Formation; D013552:Swine