The effect of monoacetin and calcium chloride on acid-base balance and survival in experimental sodium fluoroacetate poisoning.
Sodium fluoroacetate (compound "1080") was injected intravenously, 3 mmol/kg, to artificially-ventilated anesthetized cats. Blood pressure, ECG, acid-base parameters and serum ionized calcium were monitored in four groups of cats. Group A served as control. Group B cats were treated with calcium chloride to restore normal values of serum ionized calcium. Group C was given monoacetin (glyceryl monoacetate), 0.5 ml/kg every 30 min. Both monoacetin and calcium chloride were given to cats in group D. Fluoroacetate poisoning caused significant decrease in ionized calcium and severe metabolic acidosis with increased levels of lactate and pyruvate. The lactate to pyruvate ratio remained normal as long as there was no significant drop in blood pressure. Correction of blood ionized calcium prolonged survival from 94 to 166 min (group B). Monoacetin prolonged average survival time to 166 min. Metabolic acidosis was aggravated in monoacetin-treated animals (group C). Combined treatment with monoacetin and calcium chloride did not prolong mean survival time above 166 min.
D000137:Acid-Base Imbalance / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D000931:Antidotes; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000097:blood; D002122:Calcium Chloride / Q000627:therapeutic use*; D002415:Cats; D005463:Fluoroacetates / Q000506:poisoning*; D005989:Glycerides / Q000627:therapeutic use*; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D011773:Pyruvates / Q000097:blood; D019289:Pyruvic Acid; D013997:Time Factors
D000931:Antidotes; D005463:Fluoroacetates; D005989:Glycerides; D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; C038923:monoacetin; D019289:Pyruvic Acid; C014815:fluoroacetic acid; D002122:Calcium Chloride; D002118:Calcium