Effect of prostaglandin E2 alpha on the hCG-stimulated progesterone production by human corpora lutea.
The effect of prostaglandin PGF2 alpha on the hCG stimulated and basal progesterone production by human corpora lutea was examined in vitro. hCG (40 i.u./ml) stimulated progesterone formation in corpora lutea of early (days 16-19 of a normal 28 day cycle), mid (days 20-22) and late (days 23-27) luteal phases. This stimulation was inhibited by PGF2 alpha (10 micrograms/ml) in corpora lutea of mid and late luteal phases. PGF2 alpha alone did not show a consistent effect on basal progesterone production. The inhibition of hCG stimulated progesterone production by PGF2 alpha at times corresponding to luteolysis indicates a role for that prostaglandin in the process of luteolysis in the human corpus luteum.
D000328:Adult; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D003338:Corpus Luteum / Q000187:drug effects / Q000502:physiology*; D015237:Dinoprost; D004347:Drug Interactions; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008183:Luteal Phase; D008875:Middle Aged; D011374:Progesterone / Q000096:biosynthesis*; D011460:Prostaglandins F / Q000494:pharmacology*
D006063:Chorionic Gonadotropin; D011460:Prostaglandins F; D011374:Progesterone; D015237:Dinoprost