Seasonal variation in platelet 3H-imipramine binding: comparable values in control and depressed populations.
Recent findings of reduced 3H-imipramine binding in platelets of depressed patients compared to healthy controls have been proposed as a biological marker of depression. However, these studies failed to consider the possible occurrence of seasonal variation in the binding characteristics. Our results show a highly significant seasonal variation in platelet 3H-imipramine binding which occurs in both normal and depressed populations. Furthermore, when annual rhythms are taken into account, there is no difference in the binding parameters in the two populations.
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood; D001792:Blood Platelets / Q000378:metabolism*; D003866:Depressive Disorder / Q000097:blood*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000097:blood*; D008297:Male; D011618:Psychotic Disorders / Q000097:blood; D012621:Seasons; D014316:Tritium
D014316:Tritium; D007099:Imipramine