Serum erythropoietin (ESF) levels and erythroid progenitors (CFU-Es) of patients with chronic myeloproliferative disorders.
Serum erythropoietin (ESF) levels and the numbers of marrow and blood erythroid progenitors (CFU-Es) of patients with chronic myeloproliferative disorders (CMPD) were studied simultaneously. The numbers of marrow and blood CFU-Es per 1 x 10(5) cells were normal or greatly elevated. There was an inverse correlation between the hemoglobin concentration and the serum ESF level in patients with chronic myelogenous leukemia when the hemoglobin concentration ranged from 9.0 to 13.0 g/100 ml. The serum ESF level was closely related to the hemoglobin concentration in CMPD and it was suggested that the negative feedback mechanism might operate in anemic patients with CMPD.
D000328:Adult; D000818:Animals; D001854:Bone Marrow Cells; D002452:Cell Count; D002908:Chronic Disease; D004921:Erythropoietin / Q000097:blood*; D005260:Female; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood; D008297:Male; D051379:Mice; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000097:blood* / Q000473:pathology; D011087:Polycythemia Vera / Q000097:blood; D055728:Primary Myelofibrosis / Q000097:blood; D013922:Thrombocytosis / Q000097:blood
D006454:Hemoglobins; D004921:Erythropoietin