[Release of prostaglandins by spleen cells in the mouse after incubation with thymosin].
The effects of i.p. administration in mice of a rabbit antiserum specific for thymic epithelial cells on T-dependent cellular immune response has been studied. As measure of T-dependent cellular immune response were taken: 1) a delayed type hypersensitivity test based on the swelling of footpad following SRBC injection in immunized mice; 2) a graft-versus-host assay valuated by splenomegaly induced in newborn mice after donors mice spleen cells i.p. injection. Both assays showed a significant reduction of cellular T-dependent immune response. The cinetic of this effect is in accord with ultrastructural changes in mice thymus, following the same treatment, previously observed.
D000818:Animals; D015232:Dinoprostone; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011453:Prostaglandins / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism; D013154:Spleen / Q000187:drug effects / Q000378:metabolism*; D013947:Thymosin / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors
D011453:Prostaglandins; D011458:Prostaglandins E; C033782:thymosin fraction 5; D013947:Thymosin; D015232:Dinoprostone; D007213:Indomethacin
Rilascio di prostaglandine da parte di cellule spleniche di topo dopo incubazione con timosina.