Abnormal biodistribution of radiogallium in persons treated with phenytoin.
After incidentally observing a patient in whom abnormal uptake of gallium-67 citrate appeared to be explained by treatment with phenytoin, we have conducted a prospective study. Of sixteen persons with a seizure disorder treated with phenytoin, five (31%) had abnormal uptake of radiogallium either in the mediastinum, pulmonary hilum or both. Of nineteen historical control patients only one had such abnormal uptake. Phenytoin may thus cause the false-positive uptake of radiogallium in lymph nodes; this finding may also prove to have nosological importance in identifying patients at particular risk of the side-effects of this drug.
D004347:Drug Interactions; D005189:False Positive Reactions; D005710:Gallium Radioisotopes / Q000378:metabolism*; D006801:Humans; D008168:Lung / Q000378:metabolism; D008482:Mediastinum / Q000378:metabolism; D010672:Phenytoin / Q000009:adverse effects*
D005710:Gallium Radioisotopes; D010672:Phenytoin