An incisor plaque model in rats.
An in vivo model for studying plaque accumulation in rats has been described. This model investigates plaque formation on the mandibular incisors in animals which have been found to be rapid plaque-formers during a pre-test period. The accessibility of these tooth surfaces permits the removal of plaque prior to initiation of tests, the use of test groups balanced on the basis of plaque-forming potential, and interim assessments of plaque formation throughout the test period. In addition, baseline plaque scores of near zero can be attained, thereby permitting investigations of the impact of experimental measures on plaque formation. Moreover, the model permits intermittent plaque assessments throughout the test period. This model was found to have adequate sensitivity to distinguish effects between antimicrobial agents known to differ in their clinical activity and to detect differences between varying concentrations of the same agent.
D000818:Animals; D002594:Cetylpyridinium / Q000008:administration & dosage / Q000494:pharmacology; D002710:Chlorhexidine / Q000008:administration & dosage / Q000494:pharmacology; D004396:Coloring Agents; D003773:Dental Plaque / Q000175:diagnosis / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006590:Hexetidine / Q000494:pharmacology; D007180:Incisor / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013295:Streptococcus mutans / Q000166:cytology
D004396:Coloring Agents; D006590:Hexetidine; D002594:Cetylpyridinium; D002710:Chlorhexidine