Comparison of iohexol and meglumine-Na diatrizoate in cerebral angiography.
A double blind investigation comparing meglumine-Na diatrizoate (290 mg I/ml) and iohexol (300 mg I/ml) showed that patients receiving iohexol experienced significantly less discomfort. Patients who received diatrizoate commonly showed transient episodes of hypertension while those who received iohexol either showed no changes or transient episodes of hypotension. No significant changes in heart rate were observed in either group.
D001794:Blood Pressure / Q000187:drug effects; D002533:Cerebral Angiography / Q000379:methods*; D003287:Contrast Media / Q000633:toxicity*; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000633:toxicity*; D004311:Double-Blind Method; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007463:Iodobenzoates / Q000633:toxicity*; D007472:Iohexol; D009325:Nausea / Q000139:chemically induced; D010146:Pain / Q000139:chemically induced; D014283:Triiodobenzoic Acids / Q000633:toxicity*; D014839:Vomiting / Q000139:chemically induced
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D007472:Iohexol