Extreme hypodiploidy in a case of myelomonocytic crisis of chronic myelogenous leukemia.
Two cytogenetically distinct populations of marrow cells were observed in a 28-year-old woman who developed a fulminant blastic crisis (BC) of chronic myelogenous leukemia (CML) after only 1 year in the chronic phase: one population with 35-36 chromosomes, the other showing 66-72 chromosomes. Cytochemical investigation demonstrated a myelomonocytic type of BC. Chromosome banding and correlation analysis of the mean karyotypes of the two populations showed that a close relationship existed between them, indicating that one population had developed from the other. The cytogenetic evidence suggests but does not prove that the cells with triploid chromosome numbers developed from the extremely hypodiploid population by duplication of the chromosome complement. The extreme cytogenetic diversity of both populations indicates that each was undergoing further cytogenetic evolution.
D000328:Adult; D000782:Aneuploidy; D001853:Bone Marrow / Q000648:ultrastructure; D002871:Chromosome Banding; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology / Q000235:genetics*