[Distribution of electric charges in 2 substances inducing tumor cell regression].
The charge distribution of anti-cancer molecules 4-thiazolidine-carboxylic acid and 2-amino-2-thiazoline hydrochloride was calculated with a CNDO/2 semiempiral quantum mechanic method. The activity seems to be related with the formation of Zn2+ and Mn2+ ions. Both molecules show local isosterism, origin of their chelating properties.
D000970:Antineoplastic Agents; D004563:Electrochemistry; D013844:Thiazoles; D053778:Thiazolidines
D000970:Antineoplastic Agents; D013844:Thiazoles; D053778:Thiazolidines; C031363:2-aminothiazoline; C003438:thiazolidine-4-carboxylic acid
Distribución de cargas eléctricas en dos inductores de regresión en células tumorales.