In vivo evidence for prostaglandin inhibitory activity in New Zealand green-lipped mussel extract.
Prostaglandin synthetase inhibitors (eg, aspirin, indomethacin and naproxen) interfere with ovulation and prolong the gestation period in the rat. These properties could provide a novel test bed for the assessment of agents with prostaglandin biosynthesis inhibitory activity. Rats were fed green-lipped mussel extract and the effects on conception and the subsequent gestation period were determined. Parturition was delayed and fetal development was retarded in the Seatone-fed animals. The observations were consistent with the known effects of nonsteroidal anti-inflammatory drugs, suggesting that Seatone does contain pharmacologically active material inhibiting prostaglandin biosynthesis.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000633:toxicity; D001827:Body Height / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects; D007743:Labor, Obstetric / Q000187:drug effects; D008297:Male; D011247:Pregnancy; D011448:Prostaglandin Antagonists; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D013723:Teratogens; D014020:Tissue Extracts / Q000494:pharmacology* / Q000633:toxicity
D000893:Anti-Inflammatory Agents; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; C027023:Seatone; D013723:Teratogens; D014020:Tissue Extracts