Evaluation of hypervitaminosis A in the rat by measurement of tibial bone breaking strain.
Using etretinate as a model compound, the bone changes characteristic of hypervitaminosis A were evaluated in the rat in terms of tibial bone-breaking strain. Dose-related effects were observed in the dose range of 5-30 mg/kg p.o. for 15 days. The model proved a simple and precise means of assessing hypervitaminosis A in this species. Isotretinoin also showed a small but significant reduction in tibial breaking strain, but with a shallow dose-response curve in the range of 50-150 mg/kg.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001842:Bone and Bones / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D005050:Etretinate / Q000633:toxicity*; D005260:Female; D015474:Isotretinoin; D051381:Rats; D013718:Tensile Strength / Q000187:drug effects; D013978:Tibial Fractures / Q000139:chemically induced; D014212:Tretinoin / Q000633:toxicity*; D014801:Vitamin A / Q000633:toxicity*
D014801:Vitamin A; D014212:Tretinoin; D005050:Etretinate; D015474:Isotretinoin