Prostaglandins in human mammary cancer.
Prostaglandins E2 and F2 alpha (PGE2 and PGF2 alpha) were measured by Gas Liquid Chromatography-Mass Spectrometry (GLC-MS) in extracts of 100 human mammary carcinomas. All tumours contained measurable amounts of both prostaglandins but wide variations between individual tumours were observed. Values for PGE2 ranged from 7 to 762 ng g-1 tissue with a median of 100 ng g-1 tissue. Values for PGF2 alpha ranged from 3 to 475 ng g-1 tissue (median 60 ng g-1 tissue). There was a highly significant positive correlation between amounts of the 2 prostaglandins in individual tumours. Amounts of both PGE2 and PGF2 alpha were not significantly related to the menopausal status of the patients or the presence of oestrogen and progesterone receptors.
D001943:Breast Neoplasms / Q000032:analysis* / Q000473:pathology; D002452:Cell Count; D015237:Dinoprost; D015232:Dinoprostone; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008593:Menopause; D011458:Prostaglandins E / Q000032:analysis*; D011460:Prostaglandins F / Q000032:analysis*; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis
D011458:Prostaglandins E; D011460:Prostaglandins F; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D015237:Dinoprost; D015232:Dinoprostone