Enhancing effect of hydrocortisone acetate administration on the content of A-type particles in Ehrlich ascites tumor.
The incidence of intracytoplasmic A-particles was investigated in neoplastic and nonneoplastic cells of Swiss/ICR mice. The concentration of the virus-like particles decreased in the order of 1) invasive Ehrlich 4N ascites clone 1 tumor, 2) noninvasive Ehrlich 4N ascites clone 3 tumor, and 3) nonneoplastic cells of tumor-free mice. Four successive injections of hydrocortisone acetate, 1 mg/day/mouse, when administered after tumor inoculation, almost tripled the cellular content of A-particles in Ehrlich clone 1 tumor (P less than .001), whereas the same treatment given before tumor inoculation did not affect the particle content. The enhancing effect of the hormone was found to be dose-dependent (P = .0027). Possibly, hydrocortisone acetate accelerates the formation of A-particles by stimulating directly the virus-generating apparatus of clone 1 tumor cells.
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000633:toxicity*; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology*; D002999:Clone Cells; D003594:Cytoplasmic Granules / Q000187:drug effects* / Q000648:ultrastructure; D006854:Hydrocortisone / Q000031:analogs & derivatives* / Q000633:toxicity; D051379:Mice
D000893:Anti-Inflammatory Agents; C021650:hydrocortisone acetate; D006854:Hydrocortisone