Safety and tolerance comparison of imipenem-cilastatin to cephalothin and cefazolin.
Imipenem-cilastatin was compared, in two multicentre clinical trials, with cefazolin or cephalothin, in their efficacy, safety, and tolerance. Safety and tolerance for imipenem-cilastatin was similar to that of these two cephalosporins. There were more transient liver function test changes in the imipenem-cilastatin group, but the frequency was similar to that for beta-lactams in general. There were similar numbers of cases of transient neutropenia in each group. Clinical side effects were few for the treatment groups and all drugs were well tolerated.
D002437:Cefazolin / Q000627:therapeutic use / Q000633:toxicity*; D002512:Cephalothin / Q000627:therapeutic use / Q000633:toxicity*; D015377:Cilastatin; D003521:Cyclopropanes / Q000627:therapeutic use / Q000633:toxicity*; D006801:Humans; D007958:Leukocyte Count; D008111:Liver Function Tests; D009503:Neutropenia / Q000139:chemically induced
D003521:Cyclopropanes; D015377:Cilastatin; D002437:Cefazolin; D002512:Cephalothin