The effect of PGF2 alpha on human and rat oral mucosa.
PGF2 alpha exerts a cytoprotective effect on the oral mucous membrane against the caustics, trichloroacetic acid and silver nitrate. The prophlogistic effect of PGF2 alpha and a caustic agent acting synergistically is an exaggerated inflammatory reaction (caustic-prostaglandin reaction or CPR). Intraperitoneal pretreatment with PGF2 alpha can prevent this CPR in rats. Probably the prostaglandin pretreatment depresses the PG receptors. Intraperitoneal pretreatment with indomethacin evokes a more marked CPR in rats. Probably the indomethacine pretreatment activates the PG receptors. Histological sections of the rat oral mucosa show a much less marked reaction after PGF2 alpha pretreatment. They also show signs of more marked swelling after indomethacin pretreatment.
D000328:Adult; D000818:Animals; D001168:Arthritis / Q000188:drug therapy; D002424:Caustics / Q000009:adverse effects*; D015237:Dinoprost; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009061:Mouth Mucosa / Q000187:drug effects* / Q000473:pathology; D011460:Prostaglandins F / Q000494:pharmacology*; D051381:Rats; D012835:Silver Nitrate / Q000009:adverse effects; D014238:Trichloroacetic Acid / Q000009:adverse effects
D002424:Caustics; D011460:Prostaglandins F; D014238:Trichloroacetic Acid; D012835:Silver Nitrate; D015237:Dinoprost; D007213:Indomethacin