Prostaglandin E2 regulation of tumoristatic factor production by macrophage-like P388D1 cells.
Macrophage-like P388D1 cells, when stimulated with lipopolysaccharide (LPS), produced a factor(s) whose activity was inhibitory to growth of Lewis lung carcinoma cells. Indomethacin, a prostaglandin-synthesis inhibitor, augmented the production of tumoristatic activity by LPS-stimulated P388D1 cells, whereas exogenous prostaglandin E2 (PGE2) suppressed its secretion. These results suggest that P388D1 cells regulate their antitumor abilities by producing PGE2, which inhibits production of soluble factor(s) with tumoristatic activities.
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000633:toxicity; D002460:Cell Line; D004261:DNA Replication / Q000187:drug effects; D015232:Dinoprostone; D007213:Indomethacin / Q000494:pharmacology; D007941:Leukemia P388 / Q000503:physiopathology*; D007942:Leukemia, Experimental / Q000503:physiopathology*; D008070:Lipopolysaccharides / Q000494:pharmacology; D008175:Lung Neoplasms / Q000473:pathology; D008264:Macrophages / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D011458:Prostaglandins E / Q000494:pharmacology / Q000502:physiology*
D000970:Antineoplastic Agents; D008070:Lipopolysaccharides; D011458:Prostaglandins E; D015232:Dinoprostone; D007213:Indomethacin