ALL masquerading as AUL.
Of 597 cases of acute leukaemia in adults (greater than 16 years) seen at St. Bartholomew's Hospital, London, between May 1973 and January 1982, 412 were diagnosed as AML, 103 as ALL and 58 as Philadelphia chromosome positive blast crisis of CML (13 presenting as acute leukaemia and 45 having a prior chronic phase). The remaining 24 cases were considered to be acute undifferentiated leukaemia. Twenty-one of the latter were investigated using a panel of immunological markers at diagnosis and/or retrospectively using frozen cell suspensions. Eighteen out of 21 were shown to have a predominantly 'lymphoid' phenotype which comprised 12 cases of common ALL (two of whom were Ph1 positive), three cases of null-ALL, one case with a probable early thymic phenotype, and two cases with a monoclonal B lymphoblast phenotype. One 'common ALL' and one 'null-ALL' had a significant proportion of pre-B (cytoplasmic mu chain+) cells. One other case reacted with anti-myeloid sera. Leukaemic blasts from two patients were unreactive with all markers tested. No cases of glycophorin positive erythroleukaemia or anti-platelet (glycoprotein I) positive leukaemia were detected. These observations suggest that the overwhelming majority of acute leukaemias have an identifiable affiliation to the lymphoid or myeloid lineages and that patients diagnosed haematologically as 'AUL' might benefit by therapy appropriate for their leukaemic cell type.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D004253:DNA Nucleotidylexotransferase / Q000032:analysis; D003937:Diagnosis, Differential; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007938:Leukemia / Q000175:diagnosis* / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000175:diagnosis / Q000276:immunology; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000276:immunology; D007958:Leukocyte Count; D008214:Lymphocytes / Q000201:enzymology / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012189:Retrospective Studies
D000911:Antibodies, Monoclonal; D006680:HLA Antigens; D004253:DNA Nucleotidylexotransferase