Effect of prostaglandin F2 alpha at different stages of guinea-pig pregnancy.
It is believed that suppression of the processes by which prostaglandin F2 alpha is released from the uterus during the estrous cycle is vital to maintenance of pregnancies in guinea-pigs. Prostaglandin F2 alpha was injected into pregnant guinea-pigs at four different stages of gestation to investigate the effect increased prostaglandin might have. The study revealed an alteration in the sensitivity of the pregnancy to prostaglandin F2 alpha as pregnancy progressed. Recovery from the prostaglandin insult was more likely if the injection was given after Day 24 than before Day 18. In some animals the serum progesterone levels fell following the injection and then subsequently recovered. It appears that effects which are potentially hazardous to the pregnancy are countered in a variety of ways.
D000028:Abortion, Induced; D000818:Animals; D015237:Dinoprost; D005260:Female; D006168:Guinea Pigs; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011374:Progesterone / Q000097:blood; D011460:Prostaglandins F / Q000494:pharmacology*; D013997:Time Factors
D011460:Prostaglandins F; D011374:Progesterone; D015237:Dinoprost