Hepatic failure secondary to indicine N-oxide toxicity. A Pediatric Oncology Group Study.
Indicine N-oxide, a pyrrolizidine alkaloid, was given to a five-year-old boy with refractory acute myelocytic leukemia. Three days after receiving the drug the patient developed signs and symptoms of acute hepatic failure. The patient died nine days after receiving the drug and an autopsy showed massive hepatic necrosis. The acute hepatic failure observed in this patient may have been secondary to indicine N-oxide toxicity.
D000972:Antineoplastic Agents, Phytogenic / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury; D002675:Child, Preschool; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy; D008107:Liver Diseases / Q000473:pathology; D008297:Male; D011763:Pyrrolizidine Alkaloids / Q000009:adverse effects*
D000972:Antineoplastic Agents, Phytogenic; D011763:Pyrrolizidine Alkaloids; C013095:indicine-N-oxide