Chromosome analysis of Dalton's lymphoma adapted to the Swiss mouse: clonal evaluation and C-heterochromatin distribution.
Chromosome studies of Dalton's lymphoma, which was originally developed in the DBA/2 mouse and later adapted to a close inbred strain of the Swiss albino mouse, revealed only one rb-marker in all cells bearing a modal number (71). After several successive in vivo passages of the tumor, a new cell clone appeared with a different modal number (70) and two rb-markers. This new cell clone gradually outnumbered the stem cells and an apparent enhancement in tumorigenicity was noted. C-banding of the new cell clone revealed that one of the two telomeric heterochromatin-bearing chromosomes, originally present in the stem cells, had been involved in a Robertsonian fusion to form the additional marker chromosome. G-banded analysis indicated the noninvolvement of chromosome #15 in the fusion.
D000818:Animals; D002871:Chromosome Banding; D002999:Clone Cells; D005819:Genetic Markers; D006570:Heterochromatin / Q000648:ultrastructure*; D007621:Karyotyping; D007942:Leukemia, Experimental / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics*; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D013997:Time Factors; D014178:Translocation, Genetic
D005819:Genetic Markers; D006570:Heterochromatin