Organ specific metabolism of low density lipoprotein and high density lipoprotein.
Recent data indicate that the kidneys are the most important organ for the catabolism of HDL-apolipoproteins in the rat. This catabolic process is probably initiated by a specific HDL receptor in kidney membranes. However, it is unlikely that receptor-mediated endocytosis of intact HDL is involved in HDL-apolipoprotein degradation by kidneys, since HDL-cholesteryl esters are not taken up by the kidneys in vivo. It is proposed that the kidneys catalyze the first rate-limiting step in the degradation of HDL by "stripping" and degradation of a part of the HDL-apolipoproteins. In vivo metabolism of HDL-cholesteryl esters and LDL occurs predominantly in the liver and not to any significant extent in the kidneys.
D000818:Animals; D001053:Apolipoproteins / Q000378:metabolism; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D002788:Cholesterol Esters / Q000378:metabolism; D006498:Hepatectomy; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000096:biosynthesis / Q000097:blood / Q000378:metabolism*; D008077:Lipoproteins, LDL / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D008079:Lipoproteins, VLDL / Q000032:analysis; D008099:Liver / Q000378:metabolism; D008566:Membranes / Q000378:metabolism; D009928:Organ Specificity; D051381:Rats; D014280:Triglycerides / Q000097:blood
D001053:Apolipoproteins; D002788:Cholesterol Esters; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; C010681:apolipoprotein LDL, human; D002784:Cholesterol