Microbial conversion of anthracycline antibiotics. I. Microbial conversion of aclacinomycin B to aclacinomycin A.
Streptomyces galilaeus OBB-111 and its blocked mutant were found to convert aclacinomycin B and related anthracycline glycosides of the B type to the corresponding A-type glycosides. Only the cell fraction of cultures of S. galilaeus OBB-111 was capable of catalyzing the reaction. The activity was associated with growth but disappeared before the start of rapid production of aclacinomycins A and B.
D015250:Aclarubicin / Q000031:analogs & derivatives; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D007700:Kinetics; D009279:Naphthacenes / Q000096:biosynthesis / Q000302:isolation & purification / Q000378:metabolism; D013302:Streptomyces / Q000378:metabolism*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D009279:Naphthacenes; C011157:aclacinomycins; D015250:Aclarubicin