Use of a human tumor cloning system to screen retinoids for antineoplastic activity.
Retinoid analogs are being actively evaluated as antitumor agents in man. A human tumor cloning system was used to assess the antineoplastic activity of all-trans-retinoic acid, all-trans-retinol and 13-cis-retinoic acid. The effect of retinoids on the formation of tumor colony forming units (T-CFU) was surveyed for 67 different human tumors. These analogs showed minor activity in a variety of neoplasms. The decrease in T-CFU varied between histologic tumor types and between tumor of the same type. No significant difference between retinoid analogs was noted.
D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D006801:Humans; D066298:In Vitro Techniques; D007536:Isomerism; D015474:Isotretinoin; D012172:Retinaldehyde / Q000031:analogs & derivatives*; D013997:Time Factors; D014212:Tretinoin / Q000494:pharmacology; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology
D000970:Antineoplastic Agents; D014801:Vitamin A; D014212:Tretinoin; D015474:Isotretinoin; D012172:Retinaldehyde