Biochemically-defined differentiation markers on human early haemopoietic (K562) cells.
Both haemin, contrary to a previous report, and the tumor promoter TPA induce pronounced changes in surface protein patterns of human erythroleukaemic (K562) cells. Three major surface proteins are down-regulated by both inducers. These are not merely growth-related proteins and therefore represent candidate markers for an early stage of haemopoietic differentiation.
D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D006023:Glycoproteins / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006427:Hemin / Q000378:metabolism; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000378:metabolism* / Q000473:pathology; D008970:Molecular Weight; D011506:Proteins / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D006023:Glycoproteins; D011506:Proteins; D006427:Hemin; D013755:Tetradecanoylphorbol Acetate