Demonstration of p35 in hairy cell leukemia of Japanese patients.
Using SDS polyacrylamide gel electrophoresis (SDS-PAGE), several coworkers isolated a unique membrane protein that they named p35 from hairy cells of white patients with hairy cell leukemia. In the current study using a similar technique, p35 was identified in hairy cells from 2 of 4 Japanese patients with hairy cell leukemia. Further, p35 was immunoprecipitated from the leukemic membrane proteins of one of these two Japanese patients with an anti-hairy cell serum prepared against hairy cells of a typical white patient. Because both Japanese and white patients share the unique membrane antigen, it is proposed that the Japanese have the hairy cell leukemia as whites despite some differences in laboratory features.
D000951:Antigens, Neoplasm / Q000032:analysis*; D011232:Chemical Precipitation; D004591:Electrophoresis, Polyacrylamide Gel; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D007564:Japan; D007943:Leukemia, Hairy Cell / Q000276:immunology*; D008565:Membrane Proteins / Q000032:analysis*; D009363:Neoplasm Proteins / Q000032:analysis*
D000951:Antigens, Neoplasm; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D008565:Membrane Proteins; D009363:Neoplasm Proteins; C041018:hairy cell leukemia antigen p35, human