Early streptozotocin diabetes and hunger.
The initial effect of streptozotocin diabetes is not hyperphagia, but reduced food intake. Diabetic hyperphagia reaches maximum only after many days. Utilization of body fat may account for the delayed appearance of diabetic hyperphagia; this effect may be mediated by plasma fat metabolites. Plasma levels of free fatty acids (FFAs), ketone bodies, and glycerol are greatly elevated following STZ treatment, but return nearly to normal as diabetic hyperphagia appears.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000150:complications / Q000378:metabolism / Q000503:physiopathology*; D001068:Feeding and Eating Disorders / Q000503:physiopathology*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D006815:Hunger / Q000502:physiology*; D006963:Hyperphagia / Q000209:etiology / Q000503:physiopathology*; D050356:Lipid Metabolism; D051381:Rats; D013997:Time Factors
D005947:Glucose