Parietal cell structure during inhibition of acid secretion.
Acute, pharmacological inhibition of gastric acid secretion is paralleled by a return of the parietal cells to a resting morphology. However, some inhibitors acting on targets in the parietal cells distal to the receptors, may inhibit acid secretion without the return to a resting morphology. This is the case with e.g. picoprazole and thiocyanate. Long-term pharmacological or surgical inhibition of acid secretion may be followed by changes in the number and/or size of the parietal cells.
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology; D002415:Cats; D002452:Cell Count; D002927:Cimetidine / Q000494:pharmacology; D003864:Depression, Chemical; D004285:Dogs; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D009853:Omeprazole / Q000031:analogs & derivatives*; D010295:Parietal Cells, Gastric / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D011453:Prostaglandins / Q000494:pharmacology; D011706:Pyloric Antrum / Q000601:surgery; D012636:Secretory Rate / Q000187:drug effects; D013552:Swine; D013861:Thiocyanates / Q000494:pharmacology; D013997:Time Factors; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology
D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001562:Benzimidazoles; D011453:Prostaglandins; D013861:Thiocyanates; D002927:Cimetidine; D009853:Omeprazole; C028887:picoprazole