Gemfibrozil in combination with other drugs for severe hyperlipidemia. Preliminary study comprising four cases.
In this very early report, Dr Nash shares his insights into a newly developing approach to hyperlipidemia therapy. Four severely hyperlipidemic patients in whom maximum dietary therapy had proved ineffective showed a dramatic reduction in cholesterol and triglyceride levels when treated with multiple drugs, including gemfibrozil. These cases demonstrate that maximally effective polypharmacy can have striking results in selected patients. These provocative findings should encourage other investigators to verify or refute them.
D000328:Adult; D002784:Cholesterol / Q000097:blood; D002792:Cholestyramine Resin / Q000627:therapeutic use; D003084:Colestipol / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D015248:Gemfibrozil; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D009525:Niacin / Q000627:therapeutic use; D010421:Pentanoic Acids / Q000627:therapeutic use*; D011341:Probucol / Q000627:therapeutic use; D014280:Triglycerides / Q000097:blood; D014631:Valerates / Q000627:therapeutic use*
D008075:Lipoproteins, HDL; D010421:Pentanoic Acids; D014280:Triglycerides; D014631:Valerates; D002792:Cholestyramine Resin; D009525:Niacin; D002784:Cholesterol; D003084:Colestipol; D011341:Probucol; D015248:Gemfibrozil