Transfer of anti-HLA-DR antibodies from the mother to the child. Are DR antigens expressed on the placenta?
Materno-foetal transfer of anti-HLA-DR antibodies was studied in 7 women. In 6 cases, the antibody was induced by the current pregnancy and in one case, it was a residual antibody from a previous pregnancy. When the maternal antibody was induced by the current pregnancy, no anti-DR antibody was detected in the child. When the antibody was residual, it was weakly present in the child. A comparison was made between the materno-foetal transfer of anti-HLA-A,B,C antibodies and that of anti-DR antibodies. Anti-HLA-DR antibody placental absorption suggested that the corresponding antigens were expressed on certain placenta cells.
D005260:Female; D005312:Fetal Blood / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006801:Humans; D007112:Immunity, Maternally-Acquired; D007231:Infant, Newborn; D007518:Isoantibodies; D008297:Male; D010920:Placenta / Q000276:immunology*; D011247:Pregnancy
D006680:HLA Antigens; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D007518:Isoantibodies