Additive pulmonary toxicity with melphalan and busulfan therapy.
We report a 59-year-old patient with chronic myeloid leukemia, who developed severe interstitial lung fibrosis after short term and sequential treatment with melphalan and busulfan. The probable additive toxicity of both agents on the pulmonary tissue is discussed.
D002066:Busulfan / Q000627:therapeutic use / Q000633:toxicity*; D004357:Drug Synergism; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy; D008297:Male; D008558:Melphalan / Q000627:therapeutic use / Q000633:toxicity*; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000139:chemically induced*
D002066:Busulfan; D008558:Melphalan