[Radioprotective action of a combination of poly I-poly C and mexamine].
In experiments on (CBA X C57Bl)F1 mice irradiated with doses of 8-12 Gy a study was made of the effect of a mixture of polyI-polyC (2.5 mg/kg, 2 days before irradiation) and mexamine (30 mg/kg, 5 min before irradiation) on the survival rate of animals and the times of their death. It was shown that polyI-polyC potentiates the protective effect of mexamine not increasing its toxicity. The protective agents used in a combination decrease the "intestinal" death of irradiated animals while used separately fail to produce this effect.
D008735:5-Methoxytryptamine / Q000008:administration & dosage*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D004357:Drug Synergism; D005720:Gamma Rays; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011070:Poly I-C / Q000008:administration & dosage*; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D014363:Tryptamines / Q000008:administration & dosage*
D011837:Radiation-Protective Agents; D014363:Tryptamines; D008735:5-Methoxytryptamine; D011070:Poly I-C
Radiozashchitnoe deĭstvie kombinatsii polisI-poliTs i meksamina.