Effects of amoxapine on serotonin uptake in human blood platelets of depressed patients and normal controls.
The effect of amoxapine and imipramine on the serotonin (5-HT) uptake of blood platelets from depressed patients and normal controls was studied ex vivo or in vitro, respectively. Amoxapine was approximately one-tenth as potent as imipramine in inhibiting 5-HT uptake in blood platelets from normal controls in vitro. Both drugs inhibited 5-HT uptake in a competitive manner. However, ex vivo studies demonstrated that imipramine produced a mixed inhibition and amoxapine, a competitive inhibition of 5-HT uptake. There was no relationship between the change in the platelet affinity for 5-HT after treatment with amoxapine and clinical response to amoxapine.
D000328:Adult; D000657:Amoxapine / Q000627:therapeutic use*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D003866:Depressive Disorder / Q000097:blood* / Q000188:drug therapy; D003989:Dibenzoxazepines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000097:blood*
D003989:Dibenzoxazepines; D012701:Serotonin; D007099:Imipramine; D000657:Amoxapine