Relationships of prostaglandin levels and natural killer (NK) cell cytotoxicity of mononuclear cells in cord blood.
Natural killer cell cytotoxicity of mononuclear cells and the corresponding plasma prostaglandins were examined in cord blood. Low NK cell cytotoxicity was demonstrated against three target cells: NK(K562), NK(HSV-1) and NK(Fs). Prostaglandins of the B, E and F series were examined and found to be higher than adult values. A significant correlation (p less than 0.05) between NK cell cytotoxicity and the prostaglandin F series was demonstrated.
D003602:Cytotoxicity, Immunologic; D015232:Dinoprostone; D005312:Fetal Blood / Q000032:analysis*; D006801:Humans; D007231:Infant, Newborn; D007694:Killer Cells, Natural / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D011453:Prostaglandins / Q000097:blood*; D011456:Prostaglandins B / Q000097:blood; D011458:Prostaglandins E / Q000097:blood; D011460:Prostaglandins F / Q000097:blood
D011453:Prostaglandins; D011456:Prostaglandins B; D011458:Prostaglandins E; D011460:Prostaglandins F; D015232:Dinoprostone