Inhibition of denuded mouse oocyte meiotic maturation by tumor-promoting phorbol esters and its reversal by retinoids.
Two tumor-promoting phorbol esters, phorbol 12,13-dibutyrate (PDBu) and phorbol 12-myristate 13-acetate (PMA), when added to the culture medium of denuded mouse oocytes prevent their spontaneous meiotic maturation, whereas phorbol 13-acetate, which is inactive as a tumor promoter, does not inhibit this process. Retinoids appear to antagonize this inhibitory action of tumor promoters. However, the inhibitory effect of forskolin on meiotic maturation is not prevented, but is potentiated by retinal. These data indirectly suggest a role for calcium and/or phospholipids in the regulation of meiotic maturation. They also suggest that forskolin and phorbol esters mediate their effects through different pathways.
D000818:Animals; D005576:Colforsin; D004224:Diterpenes / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D008540:Meiosis / Q000187:drug effects*; D051379:Mice; D009865:Oocytes / Q000166:cytology* / Q000187:drug effects; D015240:Phorbol 12,13-Dibutyrate; D010703:Phorbol Esters / Q000494:pharmacology*; D010704:Phorbols / Q000494:pharmacology*; D012176:Retinoids / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D004224:Diterpenes; D010703:Phorbol Esters; D010704:Phorbols; D012176:Retinoids; D005576:Colforsin; D015240:Phorbol 12,13-Dibutyrate; D013755:Tetradecanoylphorbol Acetate