Translational and cotranslational events in fibrinogen synthesis.
What we have shown in these studies are some of the first steps in the assembly of fibrinogen. We believe that using the hepatocyte culture system together with molecules capable of stimulating an increase in synthesis holds much promise in helping to learn how the cell puts together this elegant and complicated molecule. Moreover, these studies may also provide clues to mechanisms operant for other complex proteins produced by the liver.
D000595:Amino Acid Sequence; D000818:Animals; D005340:Fibrinogen / Q000096:biosynthesis*; D046911:Macromolecular Substances; D008862:Microsomes, Liver / Q000378:metabolism; D008970:Molecular Weight; D011132:Polyribosomes / Q000378:metabolism; D014176:Protein Biosynthesis; D051381:Rats
D046911:Macromolecular Substances; D005340:Fibrinogen