Familial cutaneous malignant melanoma: autosomal dominant trait possibly linked to the Rh locus.
Segregation and linkage analyses were undertaken in families with multiple cases of cutaneous malignant melanoma (CMM) and a recently-described melanoma precursor, the dysplastic nevus syndrome (DNS). Clinical and laboratory data, including 23 genetic markers, were collected on 401 members of 14 high-risk kindreds. Pedigree analysis was compatible with an autosomal dominant mode of inheritance for the familial CMM trait. Although a similar model probably applies to the DNS trait as well, segregation analysis could not confirm the presence of a major locus. However, linkage analysis suggested that an autosomal dominant model was appropriate for the DNS, and that a DNS/CMM susceptibility gene may be located on the short arm of chromosome 1, within 30 map units of the Rh locus [maximum logarithm of odds (lod) score = 2.00].
D002877:Chromosomes, Human / Q000032:analysis; D002900:Chromosomes, Human, 1-3; D005787:Gene Frequency; D005799:Genes, Dominant; D005808:Genes, Recessive; D008040:Genetic Linkage; D006801:Humans; D008545:Melanoma / Q000235:genetics*; D008957:Models, Genetic; D010375:Pedigree; D011336:Probability; D012878:Skin Neoplasms / Q000235:genetics*