Loiasis and renal failure.
A patient with a filarial infection due to Loa loa and renal failure was treated with a modified regimen of diethylcarbamazine while receiving hemodialysis. Infection with Loa loa may be associated with glomerulonephritis due to immunologically mediated injury. Serum immune complexes were elevated in our patient, and a kidney biopsy specimen revealed globally sclerosed glomeruli. As gauged by the clearance of the microfilaremia, the treatment regimen proved safe and effective.
D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis; D004049:Diethylcarbamazine / Q000627:therapeutic use; D005368:Filariasis / Q000150:complications*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D007684:Kidney Tubules / Q000473:pathology; D008117:Loa / Q000302:isolation & purification; D008118:Loiasis / Q000150:complications* / Q000188:drug therapy; D008297:Male; D006435:Renal Dialysis; D012598:Sclerosis
D000936:Antigen-Antibody Complex; D004049:Diethylcarbamazine