Treatment of L-asparaginase allergic reaction.
The treatment of an allergic reaction to L-asparaginase is discussed in the presentation of a case of a 26-year-old man with chronic myelogenous leukemia who was undergoing methotrexate-L-asparaginase rescue therapy. The possible mechanism of action of L-asparaginase is reviewed, and precautions for use of L-asparaginase in combination therapy with methotrexate are presented.
D000328:Adult; D001215:Asparaginase / Q000009:adverse effects* / Q000627:therapeutic use; D004342:Drug Hypersensitivity / Q000628:therapy*; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy; D008297:Male
D001215:Asparaginase