Mutation frequency in nurses and pharmacists working with cytotoxic drugs.
Individuals occupationally exposed to cytotoxic drugs may be at risk owing to the effects of these agents on DNA. As an index of DNA damage, in vivo mutations were measured in lymphocytes from 24 oncology nurses or pharmacists and 24 matched controls. Mutation frequency was significantly increased in exposed individuals and appeared to be related to duration of exposure. However, the overall magnitude of the increase was small and its biological significance remains to be determined.
D000328:Adult; D000970:Antineoplastic Agents / Q000633:toxicity*; D002999:Clone Cells; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D008214:Lymphocytes / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D009154:Mutation; D009726:Nurses; D009784:Occupational Diseases / Q000139:chemically induced*; D010595:Pharmacists; D012306:Risk; D013866:Thioguanine / Q000494:pharmacology; D013997:Time Factors
D000970:Antineoplastic Agents; D007041:Hypoxanthine Phosphoribosyltransferase; D013866:Thioguanine