Albumin-catalyzed metabolism of prostaglandin D2. Identification of products formed in vitro.
Human albumin catalyzed the in vitro transformation of prostaglandin D2 into three novel dehydration products identified as 9-deoxy-11-keto-15 alpha-hydroxy-delta-5,9,12-prostenoic acid; 15-deoxy-11-keto-9 alpha-hydroxy-delta 5,9,12,14-prostenoic acid. Results suggest that albumin can influence, qualitatively and quantitatively, the metabolism of eicosanoids.
D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015230:Prostaglandin D2; D011457:Prostaglandins D / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism*
D011457:Prostaglandins D; D012709:Serum Albumin; D015230:Prostaglandin D2