Influence of 3-methoxy 5,7,3',4'-tetrahydroxyflavan (ME) on experimental periodontitis in the golden hamster.
Experimental periodontal disease was induced in golden hamsters by feeding the animals with a Keyes 2 000 diet. The aim of the present study was to investigate the effect of 3-methoxy 5,7,3',4'-tetrahydroxyflavan (ME), a flavanoid derivative, on periodontally induced changes by this diet which was fed ad libitum to half of the animals for 2 months prior to the start of drug therapy. The animals were then divided into 4 groups: A) control animals on normal diet; B) ME-treated (200 mg/kg 3 times a week i.p.) animals on normal diet; C) animals on Keyes 2 000 diet; D) ME-treated (200 mg/kg 3 times a week i.p.) animals on Keyes 2 000 diet. ME inhibited the diminution of bone volume as measured morphometrically. The growth of dental plaque as evaluated by a sensitive index (PII) appeared to be retarded by ME. The average PII in the ME-treated animals reached after 2 months of diet remained unchanged during the drug therapy period (4 months); whereas it was significantly increased in the group C hamsters. The biochemical data further suggest that the resorption process of the alveolar bone was decreased by ME.
D000818:Animals; D002392:Catechin / Q000031:analogs & derivatives; D006224:Cricetinae; D003774:Dental Plaque Index; D004032:Diet; D004353:Drug Evaluation, Preclinical; D005419:Flavonoids / Q000627:therapeutic use*; D008297:Male; D008647:Mesocricetus; D010518:Periodontitis / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors
D005419:Flavonoids; C029339:meciadanol; D002392:Catechin