HLA antigens in Greek patients with thyrotoxicosis (Graves' disease and toxic nodular goiter).
HLA-A and B-antigens were tested by a standard microlymphocytotoxicity technique in 126 controls and 225 thyrotoxic patients of Greek origin [173 with Graves' disease and 52 with toxic nodular goiter (TNG)]. We found: i) an increased frequency of HLA-B8 (21.4% versus 7.1%) and a decreased frequency of HLA-B12 (2.9% versus 18.2%) in Graves' disease when compared with controls; ii) no differences in the distribution of HLA-A, -B antigens in TNG, when compared with either controls or Graves' disease. These findings suggest that the associations between HLA-A, -B antigens and Graves' disease in Greek patients are similar to those reported in other caucasians. The absence of any correlation between HLA-A, -B and TNG provides additional laboratory evidence that TNG and Graves' disease represent different entities.
D000328:Adult; D000367:Age Factors; D000368:Aged; D005260:Female; D006044:Goiter, Nodular / Q000276:immunology*; D006111:Graves Disease / Q000276:immunology*; D006115:Greece; D006680:HLA Antigens / Q000032:analysis*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006720:Homozygote; D006801:Humans; D006980:Hyperthyroidism / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens