DOM-stimulus generalization to LSD and other hallucinogenic indolealkylamines.
Stimulus generalization studies were conducted using rats trained to discriminate 1.0 mg/kg of the phenalkylamine hallucinogen 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) from saline in a two-lever operant procedure. The results suggest that certain indolealkylamine hallucinogens, including LSD and several alpha-methyltryptamine, N,N-dialkyltryptamine and beta-carboline derivatives, are capable of producing stimulus effects similar to those produced by DOM. Furthermore, for twelve agents where human data are available, a significant correlation exists between discrimination-derived ED50 values and hallucinogenic potency.
D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine / Q000494:pharmacology*; D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D002243:Carbolines / Q000494:pharmacology; D005795:Generalization, Stimulus / Q000187:drug effects*; D006213:Hallucinogens / Q000494:pharmacology*; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D008297:Male; D004130:N,N-Dimethyltryptamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000662:Amphetamines; D002243:Carbolines; D006213:Hallucinogens; D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine; D008238:Lysergic Acid Diethylamide; D004130:N,N-Dimethyltryptamine