Resonance thrombography.
Resonance Thrombography is a method to follow up the coagulation process ex vivo from its very beginning up to its final consolidation phase resp. fibrinolysis. The mode of measurement is adopting the resonance effect of fibrin elasticity. The connection of a cylindric rod and outer cylinder by elastic fibrin fibres will increase the potential natural frequency (38 Hz) of the elastically suspended rod, to which a constant orbital drive of a very small radius is imported electronically. Change of difference between constant drive frequency and varying resonance frequency over time will result in sensitive registration of the Resonance Thrombogram (RTG). The orbital movement of the rod causes a circular flow of blood as long as it is fluid. The speed of flow is comparable to that in a medium sized vein, resembling a physiological situation. The clinical application of RTGraphy is regarding the fact, that there is practically no disturbance of clotting process which is not represented in any change of clot construction. Diagnosis of DIC, demonstration of SFMC as well as of fibrinolysis, differentiation between the effect of fibrin structure and of platelet activity are among the clinical assignments of RTGraphy.
D000328:Adult; D001777:Blood Coagulation; D004211:Disseminated Intravascular Coagulation / Q000097:blood; D004548:Elasticity; D005260:Female; D005337:Fibrin / Q000502:physiology; D005340:Fibrinogen / Q000378:metabolism; D005342:Fibrinolysis; D006801:Humans; D008722:Methods; D012212:Rheology; D013921:Thrombocytopenia / Q000097:blood
D005337:Fibrin; D005340:Fibrinogen