Epidemic and endemic HLA-B and DR associations in mucocutaneous lymph node syndrome.
HLA-A,B and DR antigens were evaluated in 51 patients with mucocutaneous lymph node syndrome (Kawasaki disease) during both endemic and epidemic periods in the Boston area. Although 80% of patients were HLA-B5 (70% HLA-Bw51) during endemic periods, there were no HLA-B5 individuals during the epidemic period. There was, however, an increased incidence of HLA-Bw44 during the Boston epidemic. Such different associations in endemic versus epidemic periods suggest possible different, as yet unknown, inciting agents.
D001900:Boston; D002675:Child, Preschool; D004196:Disease Outbreaks / Q000453:epidemiology; D004198:Disease Susceptibility; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015235:HLA-B Antigens; D059948:HLA-B44 Antigen; D059949:HLA-B51 Antigen; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D008206:Lymphatic Diseases / Q000276:immunology*; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000453:epidemiology / Q000276:immunology*
D006680:HLA Antigens; D015235:HLA-B Antigens; D059948:HLA-B44 Antigen; C035270:HLA-B5 antigen; D059949:HLA-B51 Antigen; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II