Platelet-activating factor stimulation of peptidoleukotriene release: inhibition by vasoactive polypeptide.
Leukotriene (LT) release stimulated by platelet activating factor was inhibited by vasoactive intestinal polypeptide (VIP) in an in vitro rat lung preparation. This was detected by HPLC and radioimmunoassay. LTC4, although the major species in the stimulatory model used, was not detected in peptide-treated preparations and LTD4 and LTE4 levels were considerably reduced.
D000818:Animals; D015232:Dinoprostone; D007213:Indomethacin / Q000494:pharmacology; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008297:Male; D010972:Platelet Activating Factor / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013189:SRS-A / Q000378:metabolism*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D010972:Platelet Activating Factor; D011458:Prostaglandins E; D013189:SRS-A; D014660:Vasoactive Intestinal Peptide; D015232:Dinoprostone; D007213:Indomethacin