Bone resorption in cholesteatomas. An experimental study.
A model for studying different aspects of human cholesteatomas in vivo in the immunodeficient "nude' mice is described. Epithelial-mesenchymal interaction was studied in human cholesteatoma membranes, transplanted to the flank region. Findings of cystic lesions lined by stratified keratinizing epithelium were frequent and the connective tissue reaction were weak. Furthermore human cholesteatomy membranes were transplanted into the middle ear cavity of the "nude' mice. After 21-28 days bone resorption was shown in the labyrinthine capsule, not always with sign of inflammation.
D000818:Animals; D001862:Bone Resorption / Q000473:pathology*; D002781:Cholesteatoma / Q000473:pathology*; D004195:Disease Models, Animal; D004427:Ear Diseases / Q000473:pathology; D004432:Ear, Middle / Q000473:pathology; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation