Effect of 13 cis retinoic acid on early precancerous antigenic goblet-cell modifications and induction of cancer during 1,2-dimethylhydrazine carcinogenesis in rats.
The possible effect of oral 13 cis retinoic acid (13-cis-RA) on the carcinogenic process induced by 28 weekly s.c. injections of 1,2-dimethylhydrazine (DMH) in 34 Wistar rats was investigated. Using immunohistology, precancerous and cancerous stages were compared with the same stages induced by DMH without additional 13-cis-RA in 33 rats. M1 antigens, which characterize modifications in goblet-cell differentiation occurring early in rat colonic carcinogenesis, were used to investigate the possible effect of retinoids on differentiation during precancerous stages. From 3-20 weeks after the start of the experiment, no significant differences were observed in the timing of M1 antigens in the 2 groups of rats. It was also observed that 13-cis-RA had no effect on histological lesions associated with precancerous mucosa, nor on the occurrence of intestinal adenocarcinomas. Thus, under these conditions, oral administration of 13-cis-RA did not significantly inhibit precancerous or cancerous stages of intestinal carcinoma development.
D019813:1,2-Dimethylhydrazine; D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000473:pathology; D004127:Dimethylhydrazines / Q000633:toxicity*; D005260:Female; D007414:Intestinal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D015474:Isotretinoin; D008763:Methylhydrazines / Q000633:toxicity*; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000473:pathology; D011230:Precancerous Conditions / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D014212:Tretinoin / Q000494:pharmacology*
D002273:Carcinogens; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D014212:Tretinoin; D015474:Isotretinoin; D019813:1,2-Dimethylhydrazine