The influence of dose schedules and administration routes on the toxicity of potential antiviral drugs.
The influence of two differently constructed dose schedules and of two dissimilar administration routes on the subacute toxicity of the potential antiviral drug benzoxazolyl-2-formyl-S-ethyl-isothiosemicarbazone was investigated in mice. Administration of identical aliquots of the, route dependent, maximally tolerated, dose was found to cause no significant differences in weight gain in any of the schedules used, but marked changes in lethality after oral or subcutaneous administration could be demonstrated.
D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000633:toxicity*; D004334:Drug Administration Schedule; D007928:Lethal Dose 50; D051379:Mice; D013882:Thiosemicarbazones / Q000008:administration & dosage / Q000633:toxicity*
D000998:Antiviral Agents; D013882:Thiosemicarbazones; C043258:Zimet 111-74