A case of erythroleukaemia with homogeneously staining regions on chromosomes.
A case of erythroleukaemia with homogeneously staining regions on chromosomes is described. The number of chromosomes in bone marrow cells varied from 41 to 46 with a mode of 43. A variety of structural and numerical chromosomal abnormalities was observed. Two marker chromosomes with homogeneously staining regions were found in all aneuploid cells examined. Intensive chemotherapy failed to induce a remission and the patient died 3.9 months after diagnosis. The relation of the homogeneously staining regions on chromosomes to the two courses of chemotherapy prior to cytogenetic study is discussed.
D000368:Aged; D000782:Aneuploidy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001853:Bone Marrow / Q000648:ultrastructure*; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D006801:Humans; D004915:Leukemia, Erythroblastic, Acute / Q000188:drug therapy / Q000648:ultrastructure*; D007970:Leukopenia / Q000139:chemically induced; D008297:Male; D008677:Metaphase