Effect of eugenol on constrictor responses in blood vessels of the rabbit ear.
Aqueous solutions of eugenol depressed vasoconstrictor responses to exogenous norepinephrine (NE), histamine, and peri-arterial sympathetic nerve stimulation in the isolated central artery of the rabbit ear and in the isolated perfused whole rabbit ear. The depression was dose- and time-dependent, and was slowly reversible. Eugenol appeared to act as an inhibitor of smooth muscle contractility.
D000818:Animals; D004423:Ear / Q000098:blood supply*; D005054:Eugenol / Q000008:administration & dosage / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D014655:Vascular Resistance / Q000187:drug effects; D014661:Vasoconstriction / Q000187:drug effects*
D005054:Eugenol; D006632:Histamine; D009638:Norepinephrine