Prostaglandin precursors in plasma phospholipids of patients with psoriasis: effects of treatment with coal tar.
Plasma phospholipids of patients with psoriasis have significantly reduced levels of dihomogammalinolenic acid (20:3n-6), arachidonic acid (20:4n-6) and adrenic acid (22:4n-6), the precursors of the 1, 2 and homo-2 series of prostaglandins (PGs). Concentrations of the 3 series PG precursor, eicosapentaenoic acid (20:5n-3) were normal. Hospital treatment with a coal tar regime produced a rise in 20:3n-6 to levels which were significantly above normal.
D015126:8,11,14-Eicosatrienoic Acid / Q000097:blood; D000328:Adult; D003033:Coal Tar / Q000627:therapeutic use*; D005227:Fatty Acids / Q000097:blood*; D005228:Fatty Acids, Essential / Q000097:blood; D005260:Female; D006801:Humans; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000097:blood; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids / Q000097:blood; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000097:blood; D010743:Phospholipids / Q000097:blood*; D011453:Prostaglandins / Q000097:blood*; D011565:Psoriasis / Q000097:blood / Q000188:drug therapy*
D005227:Fatty Acids; D005228:Fatty Acids, Essential; D008041:Linoleic Acids; D009829:Oleic Acids; D010169:Palmitic Acids; D010743:Phospholipids; D011453:Prostaglandins; D019301:Oleic Acid; D019308:Palmitic Acid; D003033:Coal Tar; D019787:Linoleic Acid; D015126:8,11,14-Eicosatrienoic Acid