The effect of a microfilament-disrupting drug, cytochalasin B, on 6-hourly and daily eruption rates of the rat mandibular incisor.
The drug did not affect 6-hourly and daily eruption rates of the unimpeded mandibular incisor of the rat. It is suggested that the tooth eruption is not inhibited by the disruption of microfilaments because the disruption was not associated with the motility of the cells and/or that the motility of the cells is not associated with the motive force of tooth eruption. Further studies may be necessary to confirm that the effects of cytochalasin B are on both microfilaments and motility of the periodontal fibroblasts.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003571:Cytochalasin B / Q000494:pharmacology*; D007180:Incisor / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014078:Tooth Eruption / Q000187:drug effects*
D003571:Cytochalasin B