Localisation of genetic markers and orientation of the linkage group on chromosome 19.
A panel of human-rodent somatic cell hybrids containing translocation derivatives of human chromosome 19 has been used to assign the markers peptidase D, complement component 3, lysosomal mannosidase, lysosomal DNAase, chorionic gonadotropin beta-subunit, and a new polymorphic DNA sequence, to specific regions of chromosome 19. This has allowed the relative orientations of the genetic and physical maps to be established, and provides the framework for a search for the genes responsible for inherited disorders on chromosome 19, such as myotonic dystrophy and neurofibromatosis.
D000818:Animals; D002460:Cell Line; D002874:Chromosome Mapping; D002903:Chromosomes, Human, 19-20; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D009693:Nucleic Acid Hybridization
D005819:Genetic Markers; D004247:DNA