Modification of oral methotrexate absorption in children with leukemia.
The effect of administering oral methotrexate in different formulations to children with acute lymphoblastic leukemia was evaluated. Methotrexate tablets alone achieved higher mean plasma levels and larger area under the absorption curve than either methotrexate liquid alone or methotrexate tablets taken concurrently with metoclopramide.
D000042:Absorption; D000284:Administration, Oral; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007700:Kinetics; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000378:metabolism*; D008727:Methotrexate / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use
D008727:Methotrexate