Gastric histology and its relationship to entero-gastric reflux after duodenal ulcer surgery.
Thirty-six volunteers, asymptomatic 7 to 22 years after various operations for duodenal ulcer, were screened for enterogastric reflux by external scanning following injection of 99mTc HIDA; they also had endoscopy for measurement of the fasting juice pH, and multiple biopsies. In patients with a pH above 4 there was an association between a positive bile reflux test and the presence of pre-malignant changes in the gastric mucosa. Carcinoembryonic antigen in the gastric mucosa was found in all patients and was not, therefore, a useful screening test for stump cancer. Blind examination of two sets of endoscopic biopsies obtained 6 weeks apart in symptomatic patients with post-operative reflux gastritis showed that histological assessment remained reproducible. Gastric biopsies obtained from 16 patients before, and a year after, Roux-en-Y gastro-jejunostomy demonstrated that foveolar hyperplasia tended to regress after bile diversion.
D001706:Biopsy; D002272:Carcinoembryonic Antigen / Q000032:analysis; D004381:Duodenal Ulcer / Q000601:surgery*; D004383:Duodenogastric Reflux / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D005750:Gastric Juice / Q000032:analysis; D005753:Gastric Mucosa / Q000473:pathology*; D005756:Gastritis / Q000209:etiology / Q000473:pathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007098:Imino Acids; D011183:Postoperative Complications / Q000473:pathology*; D011877:Radionuclide Imaging; D013667:Technetium; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid
D002272:Carcinoembryonic Antigen; D007098:Imino Acids; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid; D013667:Technetium