Antiabortifacient action of dibenzyloxyindanpropionic acid in mice.
DIPA [5,6-bis(dibenzyloxy)-1-oxo-2-propyl-2-indanpropionic acid] was evaluated for its antiabortifacient action in mice. PGF2 alpha administered intramuscularly twice daily at 525 micrograms/kg per dose starting on day-17 of gestation resulted in premature delivery (prior to day-19 of gestation) in 55% of the animals. This constituted an ED50 abortifacient dosage schedule of PGF2 alpha. Intramuscular administration of DIPA at a dose of 50 mg/kg twice daily, starting on day-15 of gestation, protected the mice against the premature delivery induced by the ED50 dosage schedule of PGF2 alpha in that only 20% of the animals delivered prematurely. In saline-treated controls, none of the animals delivered prior to day-19 of gestation. Thus, DIPA appears to be an effective antiabortifacient agent.
D000022:Abortion, Spontaneous; D000818:Animals; D000831:Animals, Newborn; D001699:Biometry; D001835:Body Weight / Q000187:drug effects; D015237:Dinoprost; D010064:Embryo Implantation / Q000187:drug effects; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D005313:Fetal Death; D007189:Indans / Q000494:pharmacology*; D007192:Indenes / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011460:Prostaglandins F / Q000494:pharmacology; D012744:Sex Ratio
D007189:Indans; D007192:Indenes; D011460:Prostaglandins F; C038352:5,6-bis(dibenzyloxy)-1-oxo-2-propyl-2-indanpropionic acid; D015237:Dinoprost