Modulation of plasma cyst(e)ine by cisplatin.
Some types of human malignant cells are cyst(e)ine auxotrophs. In 8 cancer patients given 10 courses of treatment cisplatin caused a mean (+/- S.D.) 83 +/- 17% decrease in plasma cyst(e)ine when measured before and 6 hr after drug infusion. The magnitude of the decrease correlated with peak plasma cisplatin concentration, and serial measurements demonstrated that in some patients plasma cyst(e)ine was still decreasing at 6 hr. The mean 6-hr plasma cyst(e)ine was low enough (9 +/- 9 microM) to prevent the proliferation of human promyelocytic (HL-60) cells in culture.
D002455:Cell Division; D002851:Chromatography, High Pressure Liquid; D002945:Cisplatin / Q000378:metabolism* / Q000627:therapeutic use; D003545:Cysteine / Q000097:blood*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology; D009369:Neoplasms / Q000097:blood* / Q000188:drug therapy; D013997:Time Factors
D003545:Cysteine; D002945:Cisplatin