The information contained in multiple sibling pairs.
In a sibship of size s, s(s-1)/2 sib pairs can be formed, but these pairs are statistically dependent when s greater than 2. This study examines how much independent information is obtained when all possible pairs are used to evaluate the sharing of genes identical by descent. A logarithmic measure of information, sigma pilog2pi [Shannon, 1948], is used. The basic unit of information is the binomial "bit," or the amount of information in the toss of a fair coin. It is shown that a single independent sib pair contains 1.5 bits. The complete sibship contains a total of 2s-3+(1/2)s-1 bits, or (2s-3+(1/2)s-1)/1.5 pair-equivalents of information. The information is reduced if all sib genotypes do not occur with equal probability.
D001699:Biometry; D005819:Genetic Markers; D005826:Genetics, Medical; D005838:Genotype; D006801:Humans; D008957:Models, Genetic
D005819:Genetic Markers