[Familial Alzheimer's disease: a study of HLA markers].
We have studied HLA markers in family with 2 "Probable" and 2 "possible" cases of Alzheimer disease over 3 generations. Three of them (two brothers and the father) present A29 C-B12 DR2 haplotype. It seems that it exists an association between HLA system and Alzheimer disease but we cannot define the character of this genetic linkage; the study of many families and sporadic cases will allow to define it.
D000544:Alzheimer Disease / Q000235:genetics* / Q000276:immunology; D005260:Female; D005819:Genetic Markers; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008297:Male; D010375:Pedigree
D005819:Genetic Markers; D006680:HLA Antigens
Alzheimer familial: étude des marqueurs HLA.