The effect of cholecystectomy on duodenogastric reflux in dogs and humans.
A prospective study of the effect of cholecystectomy on duodenogastric reflux (DGR) in dogs and humans has been performed and compared with patients presenting with persisting symptoms following cholecystectomy several years earlier. After an intravenous injection of 99mTc EHIDA, assessment of DGR was made by measuring Bilirubin Output and the percentage of 99mTc EHIDA recovered in gastric juice over fifteen minute periods. Cholecystectomy resulted in a significant increase in both amount and frequency of DGR in dogs and patients. Patients with persisting symptoms following cholecystectomy showed the greatest amount and frequency of DGR. We suggest that increased DGR may be an aetiological factor in some patients with persisting symptoms following cholecystectomy.
D000818:Animals; D002763:Cholecystectomy / Q000009:adverse effects*; D004285:Dogs; D004383:Duodenogastric Reflux / Q000000981:diagnostic imaging / Q000209:etiology*; D005750:Gastric Juice / Q000032:analysis; D006801:Humans; D007098:Imino Acids; D011446:Prospective Studies; D011877:Radionuclide Imaging; D013667:Technetium; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid; D013997:Time Factors
D007098:Imino Acids; D019784:Technetium Tc 99m Diethyl-iminodiacetic Acid; D013667:Technetium