A new gene that controls the type of leukemia induced by Friend murine leukemia virus.
NB tropic Friend murine leukemia virus (F-MuLV) replicates equally well in BALB/c and C57BL mice inoculated as neonates but causes almost exclusively erythroblastosis in BALB/c mice and nonerythroid (lymphoid and myelogenous) leukemias in C57BL mice. The C57BL resistance to erythroblastosis appears to be controlled by a single dominant gene in first and second backcrosses to BALB/c. This resistance to erythroblastosis is distinct from other genes known to affect susceptibility to Friend virus including Fv-1, Fv-2, H-2, Rfv-3, Fv-4, and Rmcf. We suggest the name Fhe for the new gene controlling susceptibility to Friend helper virus erythroblastosis.
D000818:Animals; D003433:Crosses, Genetic; D004900:Erythroblasts / Q000473:pathology*; D004912:Erythrocytes / Q000473:pathology*; D005622:Friend murine leukemia virus / Q000254:growth & development; D005799:Genes, Dominant; D007113:Immunity, Innate; D007942:Leukemia, Experimental / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D015470:Leukemia, Myeloid, Acute / Q000209:etiology / Q000235:genetics; D008223:Lymphoma / Q000209:etiology / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics*; D008810:Mice, Inbred C57BL / Q000235:genetics*