Five-day storage of platelet concentrates. II. In-vivo studies.
Following in-vitro tests it was concluded that platelet concentrates stored for 5 days at 22 degrees C in polyolefin containers, coded PL732, should be as effective in clinical practice as similar concentrates stored in the standard PVC containers, coded PL146. These predictions have been confirmed by the following in-vivo tests; autologous survival studies in volunteers, determination of recovery, platelet increment calculations 1 and 24 h after transfusion and clinical appraisal after transfusion of haemorrhagic thrombocytopenic patients. Bacteriological cultures of the platelet concentrates were sterile after storage for more than 5 days. It can be concluded that the 5-day storage of platelet concentrates in these containers is a practical proposition.
D001769:Blood / Q000382:microbiology; D001792:Blood Platelets / Q000166:cytology*; D001793:Blood Preservation / Q000379:methods*; D001804:Blood Transfusion, Autologous; D002470:Cell Survival; D006470:Hemorrhage / Q000097:blood; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood; D013921:Thrombocytopenia / Q000628:therapy; D013997:Time Factors