Confirming evidence for the clonal development and stem cell origin of Philadelphia chromosome-negative chronic myelogenous leukemia.
A 74-year old woman with Ph1-negative chronic myelogenous leukemia (CML) and heterozygous for glucose-6-phosphate dehydrogenase (G6PD) was studied. Both A and B types of G6PD were found in skin. In contrast, white blood cells and platelets showed only a single G6PD type A. These results provide further evidence that Ph1-negative CML has a stem cell origin and develops clonally.
D000368:Aged; D001792:Blood Platelets / Q000201:enzymology; D002904:Chromosomes, Human, 21-22 and Y; D002999:Clone Cells / Q000201:enzymology; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000201:enzymology*; D006801:Humans; D007951:Leukemia, Myeloid / Q000201:enzymology / Q000235:genetics*
D005954:Glucosephosphate Dehydrogenase