Effects of injections and/or chronic implants of melatonin and 5-methoxytryptamine on plasma thyroid hormones in male and female Syrian hamsters.
Plasma thyroid hormone concentrations in male and female Syrian hamsters were evaluated in five experiments after two pineal indoles, melatonin (MEL) and 5-methoxytryptamine (5-MT), were administered as chronic s.c. implants and/or daily afternoon injections. Circulating concentrations of thyroxine (T4), ordinarily maintained by the long photoperiod (LD 14:10), were inhibited by daily afternoon injections of 25 micrograms MEL but not 5-MT in male (experiment 1) and female (experiment 2) Syrian hamsters. The suppressive effect of MEL injections on T4 concentration in the long photoperiod was prevented in both sexes by a s.c. beeswax pellet containing either 1 mg MEL or 5-MT. In the third experiment, various doses of MEL or 5-MT were injected each afternoon for 12 weeks to compare the effectiveness of these two indoles in reducing T4 concentrations in hamsters maintained in the long photoperiod. Only the highest dose (200 micrograms) of 5-MT effectively suppressed T4 concentrations whereas all doses of MEL (greater than or equal to 5 micrograms) significantly reduced plasma T4. MEL or 5-MT (1-1,000 micrograms) were implanted in beeswax pellets in male hamsters exposed to short photoperiod (LD 10:14) to determine if either indole could prevent the short photoperiod-induced suppression of T4 (experiments 4 and 5). Regression and covariance analyses showed a significant log dose-related elevation of T4 in these hamsters, indicating equal potency of MEL and 5-MT in preventing the short photoperiod-induced suppression of T4. 5-MT given by either injection or implantation raised plasma triiodothyronine (T3) in female (experiment 2) but not in male hamsters.(ABSTRACT TRUNCATED AT 250 WORDS)
D008735:5-Methoxytryptamine / Q000494:pharmacology*; D000818:Animals; D006224:Cricetinae; D004343:Drug Implants; D005260:Female; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D008647:Mesocricetus; D013963:Thyroid Hormones / Q000097:blood*; D013974:Thyroxine / Q000494:pharmacology; D014284:Triiodothyronine / Q000494:pharmacology; D014363:Tryptamines / Q000494:pharmacology*
D004343:Drug Implants; D013963:Thyroid Hormones; D014363:Tryptamines; D014284:Triiodothyronine; D008735:5-Methoxytryptamine; D008550:Melatonin; D013974:Thyroxine