Congenital acute lymphoblastic leukemia with chromosomal abnormalities including a translocation (1;4;22).
Cytogenetic studies in a patient with inborn ALL demonstrated identical and complex abnormalities in all the cells, indicating a monoclonal origin. These abnormalities included, among others, a translocation (1;4;22).
D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002900:Chromosomes, Human, 1-3; D002904:Chromosomes, Human, 21-22 and Y; D002905:Chromosomes, Human, 4-5; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000235:genetics*; D007621:Karyotyping; D007938:Leukemia / Q000151:congenital / Q000235:genetics; D007945:Leukemia, Lymphoid / Q000151:congenital / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic