Cytochrome P-450 and steroidogenic activities of the human placental mitochondria.
The relationship between cytochrome P-450 concentration, cholesterol side-chain cleavage and 3 beta-hydroxysteroid dehydrogenase/isomerase activity, in different density mitochondrial preparations from human term placenta has been studied. The heavy mitochondrial fraction shows a higher cytochrome P-450 concentration and cholesterol side-chain cleavage activity as compared to the light mitochondrial fraction, it has however lower cytochrome P-450AROM level and 3 beta-hydroxysteroid dehydrogenase/isomerase activity.
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005260:Female; D006801:Humans; D008928:Mitochondria / Q000378:metabolism*; D008995:Monoamine Oxidase / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011284:Pregnenolone / Q000378:metabolism; D011374:Progesterone / Q000378:metabolism; D013256:Steroids / Q000096:biosynthesis*
D013256:Steroids; D011374:Progesterone; D011284:Pregnenolone; D003577:Cytochrome P-450 Enzyme System; D002784:Cholesterol; D015096:3-Hydroxysteroid Dehydrogenases; D008995:Monoamine Oxidase