Myeloproliferative syndrome in childhood.
This report describes an atypical "myeloproliferative disorder" in a child that evolved over a 6-year period. The clinical and laboratory features resembled the adult type of chronic myelogenous leukemia, but a Philadelphia chromosome was lacking. Although the proper classification of this disorder remains uncertain, the case makes a good point for the use of diagnostic procedures such as the bone marrow core biopsy and cytogenetic studies to help unravel and define the characteristics of these unusual "myeloproliferative" disorders.
D001854:Bone Marrow Cells; D001856:Bone Marrow Examination; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D006801:Humans; D007223:Infant; D007951:Leukemia, Myeloid / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D009196:Myeloproliferative Disorders / Q000175:diagnosis* / Q000473:pathology / Q000628:therapy