67Ga and 59Fe uptake by tumor cells treated with hyperthermia or hyperthermia plus lanthanum.
The uptake of 67Ga-citrate and 59Fe-citrate by tumor cells treated with hyperthermia or with hyperthermia plus lanthanum has been studied. The comparison of these results with ion flux determinations (42K) appears to indicate that hyperthermia alone or combined with lanthanum modifies the ionic permeability of the plasma membrane. This phenomenon seems to be responsible for the increased accumulation of 67Ga and 59Fe.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002473:Cell Wall / Q000378:metabolism; D002478:Cells, Cultured; D005710:Gallium Radioisotopes / Q000378:metabolism*; D006358:Hot Temperature; D066298:In Vitro Techniques; D007504:Iron Radioisotopes / Q000378:metabolism*; D007811:Lanthanum / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000378:metabolism*
D005710:Gallium Radioisotopes; D007504:Iron Radioisotopes; D007811:Lanthanum