Efficacy of metronidazole and fosfomycin alone and in combination in the treatment of experimentally induced intra-abdominal infections.
A reproducible experimental model of intra-abdominal infection in rats has been worked out in order to simulate intra-abdominal sepsis seen in humans and to test different antimicrobials in the treatment of intra-abdominal infections. This experimental model was used to evaluate the efficacy of metronidazole and fosfomycin alone and in combination in the treatment of intra-abdominal sepsis. Seventy per cent of the untreated animals died within two days. Within seven days, 33% of the animals receiving metronidazole alone, and 40% receiving fosfomycin alone died. Animals treated with metronidazole plus fosfomycin showed a significantly decreased mortality and increased cure rates during the experimental period.
D000005:Abdomen; D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000209:etiology; D004359:Drug Therapy, Combination; D005578:Fosfomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D000900:Anti-Bacterial Agents; D008795:Metronidazole; D005578:Fosfomycin