Meal stimulated neurotensin release following gastric partitioning for morbid obesity.
The meal stimulated neurotensin release was studied in morbidly obese patients in whom gastric partitioning was performed as treatment for the obesity. Basal neurotensin and the early postprandial response were not altered by the operation. However, the late phase response between 60 and 150 min was depressed, the integrated response being 1.27 (s.e.m. = 0.22) nmol/l. min postoperatively, to 1.66 (s.e.m. = 0.32) nmol/l. min preoperatively (P less than 0.05). As neurotensin is a peptide which inhibits gastric acid secretion and stimulates pancreatic bicarbonate release, long term ulcerogenic effects of gastric partitioning operations should be considered.
D000328:Adult; D005260:Female; D005502:Food; D005746:Gastric Emptying; D006801:Humans; D007082:Ileum / Q000378:metabolism*; D009496:Neurotensin / Q000097:blood / Q000378:metabolism*; D009765:Obesity / Q000628:therapy*; D013270:Stomach / Q000601:surgery*
D009496:Neurotensin