Complete or partial trisomy for the long arm of chromosome 1 in patients with various hematologic malignancies.
This study contains data obtained from a cytogenetic investigation of six patients with acute and chronic leukaemia. The karyotypes of bone marrow or blood cells of these patients showed a partial or complete trisomy for the long arm of chromosome 1. Three observations revealed a pronounced resistance of cell clones with 1q+ towards cytostatic therapy, and a comparatively short life span of patients after detection of 1q+. The importance of these changes for the role of some chromosomes and chromosome loci in leukaemogenesis is discussed.
D000208:Acute Disease; D001853:Bone Marrow / Q000503:physiopathology; D002871:Chromosome Banding; D002900:Chromosomes, Human, 1-3; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000235:genetics*; D007945:Leukemia, Lymphoid / Q000235:genetics; D007951:Leukemia, Myeloid / Q000235:genetics; D008677:Metaphase; D014314:Trisomy