Prolongation by interferon preparation of the survival time of mice implanted with differentiation-inducible mouse myeloid leukemia cells.
The effect of L-cell interferon (IFN) preparation on the survival times of mice implanted with two different clones (T-22 and R-4) of mouse myeloid leukemic M1 cells were examined. T-22 cells, but not variant R-4 cells, can be induced to differentiate in vitro or in vivo into macrophages and granulocytes. In vitro growth of R-4 cells was markedly suppressed by IFN, but that of T-22 cells was resistant to IFN. The survival times of mice with implanted T-22 cells were prolonged by treatment with IFN but those of mice with implanted R-4 cells were not.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D007370:Interferon Type I / Q000627:therapeutic use*; D007942:Leukemia, Experimental / Q000503:physiopathology / Q000628:therapy*; D007951:Leukemia, Myeloid / Q000503:physiopathology / Q000628:therapy*; D051379:Mice; D008815:Mice, Inbred Strains
D007370:Interferon Type I