Transplacental carcinogenesis with radioactive phosphorus.
1 An attempt was made to produce a model of osteogenic sarcoma using 32P transplacentally. 2 Fetal tissues appeared to be resistant to irradiation as no tumour was induced at an increased frequency in treated animals. 3 Tumours that normally occur in our strain (Sprague-Dawley rats) showed a clear tendancy to occur earlier in post-natal life in treated animals compared with controls.
D000818:Animals; D001859:Bone Neoplasms / Q000209:etiology; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005298:Fertility / Q000187:drug effects; D005333:Fetus / Q000528:radiation effects*; D008297:Male; D009381:Neoplasms, Radiation-Induced; D012516:Osteosarcoma / Q000209:etiology; D010761:Phosphorus Radioisotopes / Q000009:adverse effects*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000209:etiology
D010761:Phosphorus Radioisotopes