Chronic pancreatitis: results of a protocol of management.
Thirty-five patients with chronic pancreatitis of varying cause have been treated according to a protocol first introduced in 1979. At the end of a mean follow up time of 2.1 years, only 54% of patients were found to have derived benefit defined by pain relief and improved quality of life. Patients with alcoholic pancreatitis did particularly poorly, and alcoholics who continued to drink almost never benefited. Patients with dilated pancreatic ducts were more likely to do well than those with small ducts, and pancreaticojejunostomy had a satisfactory record of pain relief. Patients with biliary pancreatitis generally did well with cholecystectomy and clearance of the common bile duct. The 40-80% pancreatectomy had a poor record for pain relief, and produced diabetes in the majority of patients in whom it was used. Nothing will reverse the established pathology of chronic pancreatitis, which remains an unsatisfactory condition to treat.
D000328:Adult; D000437:Alcoholism / Q000150:complications; D002447:Celiac Plexus / Q000601:surgery; D002908:Chronic Disease; D003922:Diabetes Mellitus, Type 1 / Q000150:complications; D004108:Dilatation, Pathologic; D005069:Evaluation Studies as Topic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009407:Nerve Block; D010180:Pancreatectomy; D010183:Pancreatic Ducts / Q000473:pathology; D010195:Pancreatitis / Q000209:etiology / Q000601:surgery*; D011788:Quality of Life; D019966:Substance-Related Disorders / Q000150:complications