Polynesian bronchiectasis.
Six Polynesian children aged 8-14 years with recurrent lower respiratory infections and abnormal lung mucociliary clearance were assessed for immuno-deficiency. Measurements were made in these 6 children and in 21 healthy Polynesians of serum immunoglobulins (IgG, IgM, IgA) and complement components (C3, C4), leucocyte function tests, and T and B cell populations. A further 8 Polynesian bronchiectatics were tested for sputum secretory-IgA. There was no evidence of S-IgA deficiency and 4 had high levels. There was no evidence of immunodeficiency. Nasal epithelium was obtained from 6 children using a cytology brush and ciliated epithelium was obtained in only 4. The ultrastructure was normal although few cilia were examined.
D000293:Adolescent; D001987:Bronchiectasis / Q000276:immunology* / Q000473:pathology / Q000503:physiopathology; D002648:Child; D002923:Cilia / Q000502:physiology / Q000648:ultrastructure*; D003165:Complement System Proteins / Q000032:analysis*; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D008168:Lung / Q000648:ultrastructure; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D009093:Mucus / Q000502:physiology; D009297:Nasal Mucosa / Q000648:ultrastructure; D011114:Polynesia; D013183:Sputum / Q000276:immunology
D007071:Immunoglobulin A, Secretory; D007136:Immunoglobulins; D003165:Complement System Proteins