t(15;17) in a promyelocytic form of chronic myeloid leukemia blastic crisis.
Two simultaneous translocations, t(15;17) and t(9;22), have been observed in a chronic myelogenous leukemia patient with acute promyelocytic blastic crisis. After remission obtention only karyotypes with t(9;22) were present. The occurrence of the two translocations in the same cell argues in favor of the specificity of t(15;17) versus acute promyelocytic differentiation.
D000328:Adult; D002901:Chromosomes, Human, 13-15; D002902:Chromosomes, Human, 16-18; D004211:Disseminated Intravascular Coagulation / Q000150:complications; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications / Q000235:genetics; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic