The A-rod--a new possibility for cervical dilation and/or induction of uterine contractions for abortion or delivery by combined pharmacological and mechanical action.
A hydrogel compound (Sauflex, Special Polymers Ltd., London) which has the capacity to swell by absorbing surrounding fluid, was found to be capable of absorbing prostaglandins (PGE1, PGF2 alpha) in alcohol or saline during this process. After evaporation of the hydratized hydrogelic compound which restored its initial proportions and stiffness, rehydratization of the hydrogelic compound caused it to release the respective prostaglandin to the surrounding medium or tissues. The endocervical canal of first-trimester abortions was dilated by plain mechanical action of a rod-shaped hydrogel body (A-rod) inserted in the cervical canal. By loading the A-rod with PGF2 alpha (2-110 mg) the cervical canal was additionally widened and abortive contractions were elicited in the uterus. Further implications of the medical use of the A-rod are discussed.
D000028:Abortion, Induced / Q000295:instrumentation* / Q000379:methods; D000527:Alprostadil; D002584:Cervix Uteri / Q000187:drug effects; D004107:Dilatation and Curettage / Q000379:methods*; D015237:Dinoprost; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D011247:Pregnancy; D011458:Prostaglandins E / Q000008:administration & dosage*; D011460:Prostaglandins F / Q000008:administration & dosage*; D014590:Uterine Contraction / Q000187:drug effects*
D011458:Prostaglandins E; D011460:Prostaglandins F; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D015237:Dinoprost; D000527:Alprostadil