Food increases the bioavailability of isotretinoin.
Twenty healthy male subjects received 80 mg (2 X 40 mg SEG capsules) oral isotretinoin separated by two-week washout periods in an open randomized crossover design. Isotretinoin was administered during a complete fast, 1 hour after a standard breakfast, with a standard breakfast, or 1 hour before a standard breakfast. Blood samples were obtained at specific times over a 72-hour period. Isotretinoin blood concentrations were determined by a specific HPLC method. The relative bioavailability (AUC) of isotretinoin was found to be approximately 1.5 to 2 times greater when the dose was administered 1 hour before, concomitantly with, or 1 hour after a meal than when it was given during a complete fast. In addition, because the Cmax value is lower when the dose is administered with food rather than 1 hour after a meal, coadministration of isotretinoin with food may be the best method of administration.
D000328:Adult; D000704:Analysis of Variance; D001682:Biological Availability; D004435:Eating; D005215:Fasting; D006801:Humans; D015474:Isotretinoin; D008297:Male; D014212:Tretinoin / Q000097:blood / Q000378:metabolism*
D014212:Tretinoin; D015474:Isotretinoin