Diversion of bile and pancreatic secretion in the rat and its effect on cysteamine-induced duodenal and peptic ulcer development under maximal acid secretion.
In this investigation we assess whether diversion of bile and pancreatic secretion protects rats from ulceration under maximal acid secretion as it does in cysteamine-induced ulcers. The rats were divided into a cysteamine-group (Cy) comprising 16 rats and a secretagogue group (PC) with 18 white male rats. Half of the animals of each group were submitted to the diversion-operation (division of the duodenum distally from the pylorus, jejuno-duodenostomy and entero-y-anastomosis), Cy2 and PC2 respectively. The other animals were not operated (Cy1 and PC1). In the cysteamine group the rats were given twice cysteamine-HC1 injections subcutaneously and the PC group were given a 24 h infusion with pentagastrin and carbachol. All animals of the Cy1 group had duodenal ulcers, 3 perforated. However, only 2 rats had one ulcer each in the Cy2 group (p less than 0.01). The PC1 group totalled 30 duodenal ulcers in the 9 animals with 10 perforations, 13 ulcers in 6 animals with 3 perforations in PC2. Furthermore in PC1 group 34 gastric ulcers were found in 7 rats and only 4 ulcers in the PC2 group. It is therefore concluded, that the diversion operation provided protection against cysteamine-induced duodenal ulcers (p less than 0.01) and ulcer formation under maximal acid stimulation in the duodenum (p less than 0.02) as well as in the rat stomachs (p less than 0.05). In the PC group the restraint haltering of the animals promoted presumably a stress situation with bile reflux in the non-operated whereas in the operated animals (PC2) reflux did not occur.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D003543:Cysteamine; D004381:Duodenal Ulcer / Q000139:chemically induced* / Q000209:etiology; D004386:Duodenum / Q000601:surgery; D005744:Gastric Acid / Q000378:metabolism*; D007419:Intestinal Secretions / Q000378:metabolism; D007583:Jejunum / Q000601:surgery; D008297:Male; D010189:Pancreatic Juice / Q000378:metabolism*; D010437:Peptic Ulcer / Q000139:chemically induced* / Q000209:etiology; D051381:Rats
D003543:Cysteamine