Enhanced casein kinase II activity in human tumour cell cultures.
Casein kinase II (CKII) activity is enhanced as much as 2-3 fold in established and 4-5-fold in transformed human cell lines when compared to that of fibroblasts and primary human tumour cell cultures where CKII activity never exceeded a basic level. The high activity of CKII in transformed cells and in established cell lines was reduced to about the same basic level after treatment with heparin, a highly specific inhibitor of CKII activity. The activity of the cAMP-dependent protein kinase was virtually the same in fibroblasts and various human tumour cell lines investigated.
D047388:Casein Kinases; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D002478:Cells, Cultured; D005347:Fibroblasts / Q000201:enzymology; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D011494:Protein Kinases / Q000378:metabolism*
D006493:Heparin; D011494:Protein Kinases; D047388:Casein Kinases