Antiviral effects of amino acid derivatives with the fluorene substituent on murine leukemia viruses.
Two new amino acid derivatives with the fluorene substituent, when administered ip to female inbred ICR-CD1 mice inoculated with Friend murine leukemia virus, significantly inhibited virus-induced splenomegaly, reduced viable virus titers in spleen and plasma, and significantly prolonged survival time. These compounds also inhibited multiplication of the strains of the Friend and Moloney murine leukemia viruses in a cell culture system. The action of these compounds on murine leukemia virus was presumely different from that of tilorone.
D000818:Animals; D001769:Blood / Q000382:microbiology; D002478:Cells, Cultured; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D005449:Fluorenes / Q000494:pharmacology*; D005622:Friend murine leukemia virus / Q000187:drug effects*; D007942:Leukemia, Experimental / Q000382:microbiology; D051379:Mice; D008813:Mice, Inbred ICR; D008979:Moloney murine leukemia virus / Q000187:drug effects*; D013154:Spleen / Q000382:microbiology; D013163:Splenomegaly / Q000188:drug therapy; D014364:Tryptophan / Q000031:analogs & derivatives* / Q000494:pharmacology; D014779:Virus Replication / Q000187:drug effects
D005449:Fluorenes; C037244:N-(9H-fluoren-9-ylacetyl)tryptophan; C037245:N-(9H-fluoren-9-ylacetyl)-S-methylcysteine; D014364:Tryptophan; D003545:Cysteine