[Clinical experience with cefmetazole in the field of oral surgery].
Tissue concentrations of cefmetazole (CMZ) in rabbits were 17--49% of the blood levels at the corresponding time. Transfer pattern of CMZ was very similar to the pattern of the blood level, suggesting to be supposable the tissue concentration of CMZ. The clinical trial was studied concentrating on the observation of side effects and laboratory findings, especially the change of transaminase after anesthesia with GOF (gas-oxygen-fluothane). Four cases, who had anethesia with GOF, revealed the elevation of transaminase.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000769:Anesthesia, Inhalation; D000818:Animals; D015311:Cefmetazole; D002511:Cephalosporins / Q000627:therapeutic use*; D002513:Cephamycins / Q000009:adverse effects / Q000378:metabolism / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011817:Rabbits; D013515:Surgery, Oral; D013530:Surgical Wound Infection / Q000188:drug therapy* / Q000517:prevention & control; D000637:Transaminases / Q000097:blood
D002511:Cephalosporins; D002513:Cephamycins; D015311:Cefmetazole; D000637:Transaminases