The effect of ampicillin and colistin on post-Caesarean section endometritis with identification of possible risk factors.
Two hundred and seventy eight women undergoing Caesarean section were evaluated retrospectively to determine the value of prophylactic antibiotic treatment. The patients were divided into 2 groups: 180 women who received no prophylactic treatment and 98 who were treated prophylactically with ampicillin and colistin (Colymycin). Significantly lower rates of infection with prophylactic treatment were found in all groups studied (P less than 0.001) (P less than 0.05 in the group with premature rupture of membranes). Premature rupture of membranes was found to be the only risk factor significantly altering the rate of infection in the untreated group. Patients with premature rupture of membranes or with prolonged stay in the labour room prior to surgery had a significantly higher rate of infection even after the introduction of prophylactic treatment with ampicillin and colistin (P less than 0.001).
D000667:Ampicillin / Q000008:administration & dosage*; D002585:Cesarean Section; D003091:Colistin / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D004716:Endometritis / Q000382:microbiology / Q000517:prevention & control*; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000150:complications; D006801:Humans; D011247:Pregnancy; D011292:Premedication; D011645:Puerperal Infection / Q000382:microbiology / Q000517:prevention & control*; D012086:Reoperation; D012189:Retrospective Studies; D012306:Risk; D013997:Time Factors
D000667:Ampicillin; D003091:Colistin