Antitumor effect of human leukocyte interferon on human osteosarcoma transplanted into nude mice.
We studied the effect of human leukocyte interferon (HuIFN-alpha) on a human osteosarcoma (OS-OH) transplanted and passed serially in athymic mice. The growth of OS-OH was strikingly inhibited by HuIFN-alpha (50,000 IU/mouse), regardless of whether the interferon treatment was initiated 24 hr after tumor inoculation or 2 weeks later, when tumors had grown to an appreciable size (4-6 mm). The antitumor effect of HuIFN-alpha was found to be dose-dependent and a daily administration of HuIFN-alpha (50,000 IU/mouse) all but completely arrested the tumor growth.
D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D012516:Osteosarcoma / Q000201:enzymology / Q000473:pathology / Q000628:therapy*; D014183:Transplantation, Heterologous
D007370:Interferon Type I; D000469:Alkaline Phosphatase