Treatment of vaginal endometriosis with danazol.
Six infertile patients with vaginal endometriosis were treated with danazol at 600 mg daily for 6 months. Three patients had previously undergone surgery for pelvic endometriosis. After 4 months of danazol treatment there was a clear reduction in the size and number of the lesions in all the patients. At the end of the treatment 4 patients still had small lesions, which showed histological evidence of regressive changes. Four women became pregnant within 6 months of the termination of therapy.
D000328:Adult; D003613:Danazol / Q000627:therapeutic use*; D004715:Endometriosis / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007246:Infertility / Q000209:etiology / Q000628:therapy; D008297:Male; D011245:Pregnadienes / Q000627:therapeutic use*; D014623:Vaginal Diseases / Q000188:drug therapy*
D011245:Pregnadienes; D003613:Danazol