[Effect of prostaglandin F2 alpha on the corpus luteum of the ovary and peripheral blood plasma progesterone concentration in pregnant mice].
A study was made of the effect of prostaglandin F2 alpha on submicroscopic and histochemical structure of the yellow bodies and progesterone concentration in peripheral blood plasma in the pre-implantation period of embryonal development. Electron microscopy, radioimmunoassay and histochemical technique were applied. Apart from the signs of steroidogenesis preservation in luteocytes of the control group yellow bodies (during elevation of prostaglandin F2 alpha concentration in the body), there was a significant reduction of the activity in them of the key enzyme of the steroidogenesis, 3-beta-steroid dehydrogenase. Attention is paid to variation of the capillary system of the yellow bodies, induced by prostaglandin F2 alpha. This variation was marked by the absence of fenestration and by reactive status of endotheliocytes. It is concluded that prostaglandin F2 alpha primarily affects functional properties of steroid-producing cells. The authors suggest that there are potential links between the reduced progesterone level in peripheral blood plasma and submicroscopic changes in luteic cells and yellow body capillaries.
D015096:3-Hydroxysteroid Dehydrogenases / Q000037:antagonists & inhibitors; D000818:Animals; D003338:Corpus Luteum / Q000187:drug effects* / Q000201:enzymology; D047108:Embryonic Development / Q000187:drug effects*; D005260:Female; D051379:Mice; D011247:Pregnancy; D011374:Progesterone / Q000097:blood*; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*
D011461:Prostaglandins F, Synthetic; D011374:Progesterone; D015096:3-Hydroxysteroid Dehydrogenases
Deĭstvie prostaglandina 2 alpha na zheltoe telo iaichnika i kontsentratsiiu progesterona v plazme perifericheskoĭ krovi beremennoĭ myshi.