Promotion of 2-(ethylnitrosamino)ethanol-induced renal carcinogenesis in rats by nephrotoxic compounds: positive responses with folic acid, basic lead acetate, and N-(3,5-dichlorophenyl)succinimide but not with 2,3-dibromo-1-propanol phosphate.
The promoting effects of nephrotoxic chemicals, folic acid (FA), N-(3,5-dichlorophenyl)succinimide (NDPS), 2,3-dibromo-1-propanol phosphate (Tris-BP), and basic lead acetate (LAB), on 2-(ethylnitrosamino)ethanol (EHEN)-induced renal carcinogenesis were examined in F344 rats. The rats were treated with 0.1% EHEN in their drinking water for 1 week and then given one of the nephrotoxic chemicals for 35 weeks. FA was injected sc once a week at a dose of 300 mg/kg for the first 8 weeks and thereafter at 100 mg/kg. NDPS, Tris-BP, and LAB were mixed in the diet at concentrations of 0.5, 0.01, and 0.1%, respectively. At week 3 the right kidney was removed to enhance renal neoplasia. Renal cell tumor incidence was significantly increased by both FA and LAB and was slightly increased by NDPS, whereas Tris-BP had no effect. The data show that FA, LAB, and NDPS are promoters of EHEN-induced renal carcinogenesis.
D000818:Animals; D001835:Body Weight; D002273:Carcinogens; D004052:Diethylnitrosamine / Q000031:analogs & derivatives; D005492:Folic Acid / Q000494:pharmacology*; D007680:Kidney Neoplasms / Q000139:chemically induced*; D007854:Lead / Q000494:pharmacology*; D008297:Male; D009602:Nitrosamines; D009929:Organ Size; D009942:Organometallic Compounds; D010755:Organophosphates / Q000494:pharmacology*; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D013388:Succinimides / Q000494:pharmacology*
D002273:Carcinogens; D009602:Nitrosamines; D009942:Organometallic Compounds; D010755:Organophosphates; D009943:Organophosphorus Compounds; D013388:Succinimides; C023845:N-ethyl-N-hydroxyethylnitrosamine; C007352:N-(3,5-dichlorophenyl)succinimide; D007854:Lead; D004052:Diethylnitrosamine; C035186:2,3-dibromopropylphosphate; D005492:Folic Acid; C008261:lead acetate