Labor induction with prostaglandins.
Prostaglandins E2 and F2 alpha have been used for labor induction for more than 10 years. Many investigations have shown that these prostaglandins are effective, and within certain dosage schedules, safe oxytocics, even though the systemic administration is accompanied by side effects, mainly from the gastro-intestinal tract. Oral PGF2 appears to be the prostaglandin favored in recent years. It gives few side effects when administered in this manner. It is concluded from the present investigation and a study of the literature that oral PGE2 has certain advantages in comparison with other oxytocics for induction of labor at term, although it cannot entirely replace intravenous oxytocin. This, together with the relatively high cost of oral PGE2, will limit its use in the future for labor induction at term in normal cases.
D015232:Dinoprostone; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007751:Labor, Induced / Q000379:methods*; D010121:Oxytocin / Q000031:analogs & derivatives / Q000627:therapeutic use; D011247:Pregnancy; D011458:Prostaglandins E / Q000009:adverse effects / Q000627:therapeutic use*; D013997:Time Factors
D011458:Prostaglandins E; C004748:deaminooxytocin; D010121:Oxytocin; D015232:Dinoprostone