Heat production rate in polymorphonuclear granulocytes from patients with acute myelogenous leukaemia and healthy individuals.
Heat production rate in polymorphonuclear granulocytes (PMN) from 18 AML patients and 21 healthy individuals was measured using microcalorimetry. An increased PMN heat production rate was found in most AML patients at diagnosis and during the first 6 months of remission. In 7/7 patients showing values above the normal mean level the heat production rate decreased during sequential analysis. The increased PMN heat production rate is serum dependent and leukaemic sera induced increased calorimetric values also in PMN from healthy donors. This effect was not due to heat labile complement factors.
D001782:Blood Donors; D002151:Calorimetry; D006358:Hot Temperature; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000188:drug therapy; D009504:Neutrophils / Q000378:metabolism*; D013997:Time Factors