Isotypic and allotypic variation of human class II histocompatibility antigen alpha-chain genes.
DNA sequences of four human class II histocompatibility antigen alpha chain DNA sequences (derived from cDNA and genomic clones representing DC1 alpha, DC4 alpha, DX alpha and SB alpha) are presented and compared to DR alpha and to mouse I-A alpha and I-E alpha sequences. These data suggest possible mechanisms for the generation of polymorphism and the evolution of the DR, DC and SB families.
D000483:Alleles; D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005796:Genes; D014644:Genetic Variation; D006682:HLA-DP Antigens; D006683:HLA-DQ Antigens; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D046911:Macromolecular Substances; D051379:Mice; D011110:Polymorphism, Genetic
D006682:HLA-DP Antigens; D006683:HLA-DQ Antigens; C040626:HLA-Dx antigen; D000949:Histocompatibility Antigens Class II; D046911:Macromolecular Substances; D004247:DNA