[Acute neurological deficit in treated malignant hemopathies].
Neurological complications are frequent in the course of malignant hematological diseases. Five cases occurring in children are reported here: 4 presented with acute lymphoblastic leukemia and 1 with lymphoma. The clinical pattern was remarkably acute, with fever, seizures and a neurological deficit. Brain CT scan showed a limited hypodensity sometimes with a contrast uptake in the involved area in the first days or weeks. Seroconversion for measles virus occurred in 3 cases, associated with the presence of helix-like bodies in the cerebrospinal fluid and/or cerebral tissue. These case reports are discussed with respect to the neurological complications already reported in patients with hematologic malignancies. The hypothesis of measles-virus related encephalitis seems likely.
D000293:Adolescent; D001921:Brain / Q000473:pathology; D001927:Brain Diseases / Q000175:diagnosis / Q000209:etiology*; D002493:Central Nervous System Diseases / Q000209:etiology; D002561:Cerebrovascular Disorders / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D007049:Iatrogenic Disease; D007239:Infections / Q000150:complications; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000628:therapy; D008297:Male; D012640:Seizures / Q000209:etiology
Accidents neurologiques aigus déficitaires au cours d'hémopathies malignes traitées.