Effect of PGF-2 alpha on uterine activity, and concentrations of 13, 14-dihydro-15-keto-PGF-2 alpha in peripheral plasma during parturition in the tammar wallaby (Macropus eugenii).
Intravenous administration of PGF-2 alpha or an analogue stimulated uterine contractility in gravid uteri during seasonal quiescence and late pregnancy. The exogenous PGF-2 alpha was metabolized to 13,14-dihydro-15-keto-PGF-2 alpha (PGFM) which was assayed in peripheral plasma by a radioimmunoassay. PGFM was cleared from the circulation with a half life of 8-15 min. Blood samples were taken approximately every 6 h from Day 26 to Day 30 from tammars which were expected to give birth on Day 27-28. Basal levels of PGFM were less than 400 pg/ml, and only occasional samples contained higher PGFM concentrations. Therefore, if uterine PGF-2 alpha release is elevated at parturition in tammars, the corresponding rise of circulating PGFM is either small or of short duration.
D000818:Animals; D003008:Cloprostenol / Q000494:pharmacology; D015237:Dinoprost / Q000031:analogs & derivatives; D005260:Female; D007743:Labor, Obstetric; D007614:Macropodidae / Q000097:blood / Q000502:physiology*; D008394:Marsupialia / Q000502:physiology*; D011247:Pregnancy; D011312:Pressure; D011460:Prostaglandins F / Q000097:blood / Q000378:metabolism / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D011460:Prostaglandins F; C008228:15-keto-13,14-dihydroprostaglandin F2alpha; D003008:Cloprostenol; D015237:Dinoprost