Enhancing effect of vitamin E on murine intestinal tumorigenesis by 1,2-dimethylhydrazine dihydrochloride.
The effect of the antioxidant vitamin E on the tumor-inducing ability of 1,2-dimethylhydrazine dihydrochloride (1,2-DMH) was investigated in randomly bred Swiss mice. Three groups of mice that were 6 weeks of age at the beginning of the experiment received the following treatments: a) vitamin E acetate [DL-alpha-tocopheryl acetate (TA)] at a 4% dose level in a powdered diet for life; b) 1,2-DMH, 10 weekly sc injections at 20 micrograms/g body weight; c) combination of a and b treatments. The administration of TA enhanced the tumorigenicity of 1,2-DMH, as evidenced by statistically significant incidences of tumors in the duodenum, cecum, colon, rectum, and anus. The present finding apparently is in contrast with the reported inhibitory effect of TA on colon carcinogenesis by 1,2-DMH.
D019813:1,2-Dimethylhydrazine; D000694:Anal Gland Neoplasms / Q000139:chemically induced; D000818:Animals; D002430:Cecal Neoplasms / Q000139:chemically induced; D003110:Colonic Neoplasms / Q000139:chemically induced; D004032:Diet; D004127:Dimethylhydrazines / Q000633:toxicity*; D004357:Drug Synergism; D004379:Duodenal Neoplasms / Q000139:chemically induced; D005260:Female; D007414:Intestinal Neoplasms / Q000139:chemically induced*; D007680:Kidney Neoplasms / Q000139:chemically induced; D008297:Male; D008763:Methylhydrazines / Q000633:toxicity*; D051379:Mice; D009383:Neoplasms, Vascular Tissue / Q000139:chemically induced; D012004:Rectal Neoplasms / Q000139:chemically induced; D014810:Vitamin E / Q000494:pharmacology*
D004127:Dimethylhydrazines; D008763:Methylhydrazines; D014810:Vitamin E; D019813:1,2-Dimethylhydrazine