A general model for disease-marker association.
A general model for analysing disease-marker associations from a random sample of patients and controls is given, assuming an arbitrary number of marker and disease susceptibility alleles. A method for testing the goodness-of-fit of various disease susceptibility models to the observed distribution of genotypes at the marker locus in patient and control samples is given. The method is demonstrated using a recently published data set on type I diabetes.
D003920:Diabetes Mellitus / Q000235:genetics*; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008957:Models, Genetic
D005819:Genetic Markers