[Immunologic and enzymatic markers of acute infantile lymphoblastic leukemias].
Twenty-one childhood acute lymphoblastic leukemias were characterized immunologically by a series of classic markers--EAET rosette and surface and cytoplasm immunoglobulins--, a panel of 14 monoclonal antibodies --OKla 1, OKT3, 4, 6, 8, 9, 10, 11, cALLA, Leu-1, FMC-7, FMC-8 and 3A-1--and by assessment of terminal deoxynucleotidyl transferase enzyme. Patients were distributed in five immunological subgroups: 1) Unclassifiable/null ALL (la +, TdT+, cALLA-), one patient, 2) common ALL (la+, TdT+, cALLA+) 15 patients, 3) pre-B ALL (la+, TdT+, cALLA+, clg+) one patient, 4) B-LL (la+, TdT-, cALLA-, slg+) 3 patients, 5) T-ALL (TdT+, EAET+, la-, cALLA-), one patient, and the clinical, biological, morphological and cytochemical peculiarities characterizing each immunological variant are discussed.
D000293:Adolescent; D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D004253:DNA Nucleotidylexotransferase / Q000032:analysis; D005260:Female; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000175:diagnosis* / Q000201:enzymology / Q000276:immunology; D008297:Male; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D012397:Rosette Formation
D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D011947:Receptors, Antigen, B-Cell; D004253:DNA Nucleotidylexotransferase
Marcadores immunológicos y enzimáticos de las leucemias linfoblásticas agudas infantiles.