Cushing's syndrome with bilateral multinodular adrenal hyperplasia. Ultrastructural, histochemical, and immunohistochemical study.
An unusual case of Cushing's syndrome of a 59-year-old man with bilateral multinodular adrenal hyperplasia and microadenoma of the pituitary gland is presented. Failure to suppress plasma cortisol with large doses of dexamethasone may suggest autonomous growth of hyperplastic nodules of the adrenals, which were at first induced by prolonged stimuli of ACTH from the microadenoma of the pituitary gland. ACTH could not be detected in the microadenoma cells on paraffin sections, while Crooke's cells were strongly positive for ACTH. The interrelation between bilateral multinodular adrenal hyperplasia and pituitary microadenoma is discussed.
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D000236:Adenoma / Q000150:complications; D000311:Adrenal Glands / Q000473:pathology / Q000648:ultrastructure; D000308:Adrenocortical Hyperfunction / Q000150:complications* / Q000209:etiology / Q000378:metabolism; D003480:Cushing Syndrome / Q000209:etiology*; D005954:Glucosephosphate Dehydrogenase / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D007031:Hypothalamus / Q000648:ultrastructure; D007120:Immunochemistry; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000150:complications / Q000648:ultrastructure
D015096:3-Hydroxysteroid Dehydrogenases; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase