Effect of l-carnitine on lipid pattern in debilitated patients treated with Intralipid.
Ten surgical patients--4 males and 6 females, mean age: 46.7 years--affected by various pathological conditions were selected for this clinical trial. The patients were divided into two groups of 5 as follows: Group I on the third day received 10%. Intralipid (500 mg) + l-carnitine i.v. (100 mg/kg); on the sixth day 10% Intralipid (500 mg) infusion was given alone. Group II on the third day received 10% Intralipid (500 mg) infusion, and on the sixth day 10% Intralipid (500 mg) + l-carnitine (100 mg/kg). The laboratory parameters (cholesterol, triglycerides, HDL, LDL, VLDL, apolipoprotein A and B) showed that the lipids administered with l-carnitine were more rapidly metabolized than those without.
D002331:Carnitine / Q000494:pharmacology*; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D015243:Cholesterol, VLDL; D004734:Energy Metabolism / Q000187:drug effects; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008055:Lipids / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D008076:Cholesterol, HDL; D015243:Cholesterol, VLDL; D005217:Fat Emulsions, Intravenous; D005227:Fatty Acids; D008055:Lipids; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol; D002331:Carnitine