Exclusion of a tight linkage between familial polyposis coli and HLA.
Linkage was investigated between a dominant gene determining familial polyposis coli (FPC) and HLA in a large pedigree. A tight linkage was excluded at a value of the recombination fraction between 0 and 5%. Linkage studies with various markers should be pursued to permit detection of high risk individuals and to better understand the phenotypic variability observed in certain polyposis families.
D003110:Colonic Neoplasms / Q000235:genetics / Q000276:immunology*; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D006801:Humans; D007417:Intestinal Polyps / Q000235:genetics / Q000276:immunology*; D008285:Major Histocompatibility Complex; D008297:Male; D008875:Middle Aged; D010375:Pedigree
D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens