Inclusion complexation of prostaglandin F2 alpha with gamma-cyclodextrin in solution and solid phases.
A solid complex of prostaglandin F2 alpha (dinoprost) with gamma-cyclodextrin in a molar ratio of 1:1 was obtained on the basis of the BS-type phase solubility diagram. The mode of interaction in the solid state was studied by powder X-ray diffractometry, thermal analysis, and carbon-13 cross polarization/magic angle spinning nuclear magnetic resonance (13C-CP/MAS-NMR) spectrometry. The X-ray diffraction and NMR data suggested that prostaglandin F2 alpha is included in the cylindrical channels formed by coaxial alignment of gamma-cyclodextrin molecules to give a channel type structure. Dissolution and thermal behaviors of the prostaglandin F2 alpha-gamma-cyclodextrin complex were examined and compared with the drug itself. The result indicated that the gamma-cyclodextrin complex may have great utility as a rapidly dissolving form of prostaglandin F2 alpha with improved thermal stability.
D003505:Cyclodextrins / Q000032:analysis*; D003912:Dextrins / Q000032:analysis*; D015237:Dinoprost; D009682:Magnetic Resonance Spectroscopy; D011460:Prostaglandins F / Q000032:analysis*; D012995:Solubility; D012996:Solutions; D013213:Starch / Q000032:analysis*; D013696:Temperature; D014961:X-Ray Diffraction; D047408:gamma-Cyclodextrins
D003505:Cyclodextrins; D003912:Dextrins; D011460:Prostaglandins F; D012996:Solutions; D047408:gamma-Cyclodextrins; D013213:Starch; D015237:Dinoprost; C023792:gamma-cyclodextrin