Fasciola hepatica: increase of glycogen phosphorylase activity due to prostaglandins.
Both prostaglandin E1 (PGE1) and prostaglandin F2 alpha (PGF2 alpha) stimulate the glycogen phosphorylase (EC 2.4.1.1.) activity of Fasciola hepatica. Whole or sliced parasites were incubated with PGE1 (2.8 X 10(-7) and 2.8 X 10(-5) M) and PGF2 alpha (2.1 X 10(-7) and 2.1 X 10(-5) M) and enzyme activity was measured in homogenates prepared immediately following the incubation. No substantially different effect was noted between the two assayed doses of prostaglandins. Prostaglandins appeared to be less effective in sliced parasites.
D000527:Alprostadil; D000818:Animals; D015237:Dinoprost; D005210:Fasciola hepatica / Q000187:drug effects / Q000201:enzymology*; D006005:Phosphorylases / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013997:Time Factors
D011458:Prostaglandins E; D011460:Prostaglandins F; D015237:Dinoprost; D006005:Phosphorylases; D000527:Alprostadil