Reduction in thromboxane formation by n-3 fatty acids enriched lung microsomes from rat and guinea pig following the ingestion of dietary menhaden oil.
Feeding rats and guinea pigs on a diet containing 5% menhaden oil altered the fatty acid composition of lung microsomes. The lung microsomal phospholipids contained increased amounts of n-3 fatty acids, eicosapentaenoic (20:5) and docosahexaenoic acid (20:6), following the ingestion of menhaden oil. There was a concomitant decrease in arachidonic acid (20:4) levels in rat lung microsomes, but no significant change of this fatty acid was observed in the microsomes from guinea pigs. The ability of lung microsomes to convert 14C-arachidonic acid into thromboxane (TXB) was reduced by the enrichment of n-3 fatty acids in the microsomal lipids.
D000818:Animals; D004041:Dietary Fats / Q000494:pharmacology; D005227:Fatty Acids / Q000378:metabolism*; D005395:Fish Oils; D006168:Guinea Pigs; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D009821:Oils / Q000494:pharmacology*; D010743:Phospholipids / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013931:Thromboxanes / Q000096:biosynthesis*
D004041:Dietary Fats; D005227:Fatty Acids; D005395:Fish Oils; D009821:Oils; D010743:Phospholipids; D013931:Thromboxanes; C033266:Menhaden oil