Cardio-respiratory changes and prostaglandins during one-lung-anesthesia.
In a clinical study the intraoperative changes in prostaglandin levels and their possible influence on venous admixture during one-lung anesthesia are investigated in 9 patients undergoing abdomino-thoracic resection of a carcinoma of the oesophagus. During one-lung anesthesia PaO2 decreased and Qsp/Qt increased significantly. In 7 of the 9 patients prostaglandin E2 in the arterial blood was significantly above normal level during two-lung- and one-lung ventilation, prostaglandin F2 alpha was below normal values in all patients during two-lung- and one-lung ventilation. The clear prevalence of vasodilating prostaglandin E2 may have reduced the effectiveness of hypoxic pulmonary vasoconstriction during one-lung ventilation.
D000758:Anesthesia; D001794:Blood Pressure; D015237:Dinoprost; D015232:Dinoprostone; D004938:Esophageal Neoplasms / Q000601:surgery; D006321:Heart / Q000503:physiopathology*; D006801:Humans; D000860:Hypoxia / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011453:Prostaglandins / Q000097:blood*; D011458:Prostaglandins E / Q000097:blood; D011460:Prostaglandins F / Q000097:blood; D011652:Pulmonary Circulation; D012119:Respiration; D014661:Vasoconstriction / Q000187:drug effects
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D015237:Dinoprost; D015232:Dinoprostone