Decreased fibronectin biosynthesis by human cord blood mononuclear phagocytes in vitro.
Cultured cord blood monocytes synthesize significantly less fibronectin than cultured monocyte-macrophages from adult peripheral blood. Biosynthesis of the second component of complement in vitro is similar for both cell systems. The monocyte-macrophages from neonates and adults have similar functional and morphologic properties in long-term cultures. The decreased monocyte-macrophage biosynthesis of fibronectin observed in vitro may be in part related to the reduced plasma fibronectin concentrations and reticuloendothelial system hypofunction which occur in newborn infants.
D000328:Adult; D002478:Cells, Cultured; D003175:Complement C2 / Q000096:biosynthesis; D005312:Fetal Blood / Q000166:cytology; D005353:Fibronectins / Q000096:biosynthesis* / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D008264:Macrophages / Q000166:cytology; D009000:Monocytes / Q000166:cytology; D010586:Phagocytes / Q000378:metabolism*
D003175:Complement C2; D005353:Fibronectins