[Prostatic tissue and fluid levels of DL-8280].
The concentration of DL-8280, a new pyridone carboxylic acid, in the prostatic tissue and fluid after oral administration to man was studied. The drug was concentrated in the prostate and the concentration was dose-dependent. The ratios of prostatic tissue and fluid levels to serum levels were 1.62-1.79 and 1.65-1.96. respectively.
D000284:Administration, Oral; D000368:Aged; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000378:metabolism*; D001826:Body Fluids / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin; D010078:Oxazines / Q000008:administration & dosage / Q000378:metabolism*; D011467:Prostate / Q000378:metabolism*
D000890:Anti-Infective Agents; D010078:Oxazines; D015242:Ofloxacin