Adrenergic regulation of protein synthesis in rat submandibular salivary gland cells.
Epinephrine, a mixed alpha- and beta-adrenergic agonist, modulated new protein synthesis in dispersed rat submandibular cells. Both adrenoreceptors separately could increase protein synthesis after cells were exposed to [14C]-leucine for 10 min and then with 1 mM unlabelled leucine for 10-30 min. The extent of response was dependent on the concentration of epinephrine to which cells were exposed. Alteration in the sequence of exposure of cells to tracer and agonist changed the direction of agonist response.
D000818:Animals; D004837:Epinephrine / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology; D007930:Leucine / Q000378:metabolism; D008297:Male; D008729:Methoxamine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000502:physiology; D012471:Salivary Proteins and Peptides / Q000096:biosynthesis* / Q000378:metabolism; D013363:Submandibular Gland / Q000187:drug effects / Q000378:metabolism*
D011941:Receptors, Adrenergic; D012471:Salivary Proteins and Peptides; D007930:Leucine; D008729:Methoxamine; D007545:Isoproterenol; D004837:Epinephrine