Radioactive-induced tumors by phosphorus-32 as colloidal compound.
Chromic colloidal phosphate labeled with 32P, which has been proposed for the treatment of several articular diseases, was injected intra-articularly in the knee joint of adult Wistar rats. After a 270 days minimum latent period, tumors began to appear in the injected zone, to a 70% frequency. Ten lung metastases were detected. In five cases, squamous cell carcinomas were induced in the injected area. The relevance of a sound evaluation of the risk involved in treatments with radioactive isotopes, is discussed.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000209:etiology; D006614:Hindlimb; D007270:Injections, Intra-Articular; D007592:Joint Diseases / Q000209:etiology*; D007596:Joints; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D009374:Neoplasms, Experimental / Q000209:etiology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D012516:Osteosarcoma / Q000209:etiology; D010761:Phosphorus Radioisotopes / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains
D010761:Phosphorus Radioisotopes