Effect of prostaglandin E2 on adult pig articular cartilage slices in culture.
Confirming earlier work by other investigators in isolated chondrocyte cultures, prostaglandin E2 (PGE2) (25 micrograms/ml) causes rapid inhibition of in vitro articular cartilage proteoglycan synthesis in adult pig cartilage slices. The potential impact of E prostaglandins on articular cartilage should be considered in clinical situations associated with elevated intra-articular prostaglandin levels (trauma, meniscal injury, arthritis, etc.).
D000818:Animals; D002358:Cartilage, Articular / Q000378:metabolism*; D046508:Culture Techniques; D015232:Dinoprostone; D004305:Dose-Response Relationship, Drug; D007719:Knee Joint; D011458:Prostaglandins E / Q000494:pharmacology*; D011509:Proteoglycans / Q000096:biosynthesis*; D013431:Sulfates / Q000378:metabolism; D013552:Swine
D011458:Prostaglandins E; D011509:Proteoglycans; D013431:Sulfates; D015232:Dinoprostone