A more reliable photometric technique for the measurement of scalp sebum excretion.
The objective assessment of antiseborrhoeic therapy for the scalp requires a reliable technique for the measurement of sebaceous gland activity. Previously published methods were tried but found to be unreliable. This paper describes a photometric technique which gave repeatable results and demonstrated a reduction of sebaceous gland activity on the scalp with both oral isotretinoin and topical II alpha-hydroxyprogesterone. The accuracy of the method was achieved by careful preparation of the scalp but was affected by recent shampooing.
D000328:Adult; D005260:Female; D006801:Humans; D006908:Hydroxyprogesterones / Q000494:pharmacology; D006920:Hygiene; D015474:Isotretinoin; D008297:Male; D008875:Middle Aged; D012535:Scalp / Q000378:metabolism*; D012627:Sebaceous Glands / Q000378:metabolism; D012629:Sebum / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D013053:Spectrophotometry / Q000379:methods; D014212:Tretinoin / Q000494:pharmacology
D006908:Hydroxyprogesterones; C030228:11-hydroxyprogesterone; D014212:Tretinoin; D015474:Isotretinoin