Chromosomes and causation of human cancer and leukemia. LIII. Comprehensive cytogenetic analysis of an erythroleukemia.
A comprehensive cytogenetic analysis has been performed in a case of erythroleukemia (EL), M6 in the FAB classification. A bone marrow sample was shown to be characterized by an unusually high degree of polyploidy with the presence of a dominating hypotetraploid clone. G-banding analysis revealed extensive structural rearrangements involving chromosomes #1,#3,#12,#16,#17, and #21. The SCE frequency was higher in the cells of the dominant clone when compared to that of near-diploid, presumably nonmalignant cells. Cell cycle analysis revealed that the hypotetraploid cells progressed through the cell cycle much slower than did the near-diploid cells.
D000368:Aged; D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D003561:Cytarabine / Q000627:therapeutic use; D006801:Humans; D007621:Karyotyping; D004915:Leukemia, Erythroblastic, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D008297:Male; D008677:Metaphase; D011123:Polyploidy; D012854:Sister Chromatid Exchange
D003561:Cytarabine