Enhancing effect of bile and bile acid on stomach tumorigenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine in Wistar rats.
The carcinogenic or cocarcinogenic effects of bile or bile acid on stomach carcinogenesis were investigated in inbred W rats. Bile or bile acid was introduced into the stomach by choledochogastrostomy or with food after the administration of N-methyl-N'-nitro-N-nitrosoguanidine [(MNNG) CAS: 70-25-7; 1-methyl-3-nitro-1-nitrosoguanidine] in drinking water. The animals that received MNNG and bile or sodium taurocholate (CAS: 145-42-6; N-choloyltaurine sodium salt) had a significantly higher incidence of hyperplastic and neoplastic lesions in the stomach mucosa than did the relevant MNNG-treated controls. The result suggested an enhancing effect of bile and sodium taurocholate in stomach tumorigenesis.
D000818:Animals; D001646:Bile / Q000502:physiology*; D002273:Carcinogens; D004357:Drug Synergism; D006965:Hyperplasia; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology; D013656:Taurocholic Acid / Q000633:toxicity*
D002273:Carcinogens; D008769:Methylnitronitrosoguanidine; D013656:Taurocholic Acid