Sex selection by sperm separation and insemination.
The Ericsson albumin filtration technique was used to collect a fraction rich in Y sperm for selective insemination in couples desiring a male infant. Of 35 conceptions in which sex was known at delivery or spontaneous abortion, there were 28 males (80%). Twelve pregnancies were achieved after separation of sperm in a Sephadex gel filtration system designed to allow for collection of a fraction enriched in X sperm. Seven pregnancies have resulted in females, two in males, and one in twins of each sex. One patient aborted, and one is still pregnant. While selection for either sex can be done electively, on the basis of sociologic preference, female selection has, as an additional indication, avoidance of male offspring to carriers of sex-linked diseases.
D000328:Adult; D002850:Chromatography, Gel; D005260:Female; D005818:Genetic Engineering / Q000379:methods*; D006801:Humans; D007315:Insemination, Artificial; D008297:Male; D011247:Pregnancy; D012730:Sex Chromosomes / Q000032:analysis; D012743:Sex Preselection / Q000379:methods*; D013094:Spermatozoa / Q000032:analysis / Q000145:classification*