Inhibitory effects of molybdenum on esophageal and forestomach carcinogenesis in rats.
Male weanling inbred SD rats were given ad libitum a nutritionally adequate semipurified diet and demineralized drinking water without or with 100 or 200 ppm tungsten (W) or 2 or 20 ppm molybdenum (Mo) added to the drinking water. The animals were gastrically intubated with a solution of N-nitrososarcosine ethyl ester (NSEE) from the 4th week twice weekly for 2-8 consecutive weeks. The addition of Mo at either the 2- or 20-ppm level significantly inhibited NSEE-induced esophageal and forestomach carcinogenesis. The 200 ppm W significantly countered the inhibitory effect of a low level of Mo naturally occurring in the diet.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D004032:Diet; D004938:Esophageal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D006965:Hyperplasia / Q000139:chemically induced; D008297:Male; D008982:Molybdenum / Q000494:pharmacology*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000037:antagonists & inhibitors*; D010212:Papilloma / Q000139:chemically induced; D051381:Rats; D011919:Rats, Inbred Strains; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology; D014414:Tungsten / Q000494:pharmacology
D009602:Nitrosamines; C028099:N-nitrososarcosine ethyl ester; D008982:Molybdenum; C024687:sodium molybdate(VI); D014414:Tungsten