Sodium and calcium in lymphocytes and erythrocytes in essential hypertension.
The present study compared protein-related sodium concentrations in lymphocytes with the sodium and calcium activities in erythrocytes from 12 untreated patients with essential hypertension and 15 normal control subjects. It appeared that protein-related Na+ in lymphocytes was elevated about threefold in essential hypertensives. Comparable increases were also noted in intracellular Na+ and Ca2+ activities. The correlation between Na+ in lymphocytes and in erythrocytes was not close. These results suggest that the determination of protein-related Na+ in lymphocytes discriminates between normotensives and essential hypertensives as well as measurements of ion activities in erythrocytes. Altered intracellular ion binding may be partly responsible for the changes in intracellular protein-related Na+.
D002118:Calcium / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008214:Lymphocytes / Q000378:metabolism*; D012016:Reference Values; D012964:Sodium / Q000097:blood*
D012964:Sodium; D002118:Calcium