Murine arylsulfatase C: evidence for two isozymes.
SWR/J mice possess high arylsulfatase C, estrone sulfatase, and dehydroepiandrosterone sulfatase activities in liver, spleen, and kidney compared to A/J mice. This interstrain activity variation appears to be determined by at least 1 autosomal gene. Murine arylsulfatase C activity occurs in both hydrophobic and hydrophilic forms which differ with respect to certain biochemical properties and exhibit different subcellular distributions. The hydrophilic isozyme is a major component in kidney and brain extracts and a minor isozyme in liver and spleen extracts. The hydrophobic arylsulfatase C isozyme appears to be identical to steroid sulfatase. The hydrophilic arylsulfatase C isozyme does not possess steroid sulfatase activity; however, hydrophilic and hydrophobic arylsulfatase C share certain properties, suggesting that they may be structurally related. The autosomal gene(s) affects both arylsulfatase isozymes.
D000818:Animals; D001192:Arylsulfatases / Q000032:analysis* / Q000235:genetics; D005260:Female; D005796:Genes; D007527:Isoenzymes / Q000032:analysis* / Q000235:genetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012727:Sex Characteristics; D013045:Species Specificity; D043266:Steryl-Sulfatase; D013429:Sulfatases / Q000032:analysis*; D014018:Tissue Distribution
D007527:Isoenzymes; D013429:Sulfatases; D001192:Arylsulfatases; D043266:Steryl-Sulfatase