[Relaxation of DNA-protein interactions in mouse lymphoblastic leukemic cells exposed to antineoplastic agents].
It has been demonstrated by nucleoproteid-celite chromatography that 1-nitroso-1-methylurea, potassium cyanate and prospidin reduce DNA-protein interactions in chromatin of cell cultures from LL mice with lymphoblastic leukemia.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D003485:Cyanates / Q000494:pharmacology; D004273:DNA, Neoplasm / Q000378:metabolism*; D007945:Leukemia, Lymphoid / Q000378:metabolism*; D008770:Methylnitrosourea / Q000494:pharmacology; D051379:Mice; D009363:Neoplasm Proteins / Q000378:metabolism*; D011447:Prospidium / Q000494:pharmacology; D011485:Protein Binding / Q000187:drug effects
D000970:Antineoplastic Agents; D003485:Cyanates; D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D008770:Methylnitrosourea; D011447:Prospidium; C024835:potassium cyanate
Oslablenie DNK-belkovykh vzaimodeĭstviĭ v kletkakh leĭkoznykh limfoblastov mysheĭ pod vliianiem nekotorykh protivoopukholevykh agentov.