Chaotic behavior in dopamine neurodynamics.
We report the results of the dynamics of a model of the central dopaminergic neuronal system. In particular, for certain values of a parameter k, which monitors the efficacy of dopamine at the postsynaptic receptor, chaotic solutions of the dynamical equations appear--a prediction that correlates with the observed increased variability in behavior among schizophrenics, the rapid fluctuations in motor activity among Parkinsonian patients treated chronically with L-dopa, and the lability of mood in some patients with an affective disorder. Moreover our hypothesis offers specific results concerning the appearance or disappearance of erratic solutions as a function of k and the external input to the dopamine neuronal system.
D001921:Brain / Q000503:physiopathology*; D004298:Dopamine / Q000502:physiology*; D006801:Humans; D008433:Mathematics; D008959:Models, Neurological; D008960:Models, Psychological; D011954:Receptors, Dopamine / Q000502:physiology; D012559:Schizophrenia / Q000503:physiopathology*
D011954:Receptors, Dopamine; D004298:Dopamine