Human adenovirus type 2 but not adenovirus type 12 is mutagenic at the hypoxanthine phosphoribosyltransferase locus of cloned rat liver epithelial cells.
Using resistance to the base analog 8-azaguanine as a genetic marker, we showed that adenovirus type 2, but not adenovirus type 12, is mutagenic at the hypoxanthine phosphoribosyltransferase locus of cloned diploid rat liver epithelial cells. Adenovirus type 2 increased the frequency of 8-azaguanine-resistant colonies by up to ninefold over the spontaneous frequency, depending on expression time and virus dose.
D000260:Adenoviruses, Human / Q000235:genetics*; D000818:Animals; D001375:Azaguanine; D002999:Clone Cells; D004352:Drug Resistance, Microbial; D004847:Epithelial Cells; D005814:Genes, Viral; D005819:Genetic Markers; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics*; D008099:Liver / Q000166:cytology; D009154:Mutation; D051381:Rats
D005819:Genetic Markers; D007041:Hypoxanthine Phosphoribosyltransferase; D001375:Azaguanine