Induction of oral mucosal tumors in hamsters and rats treated with methyl(acetoxymethyl)nitrosamine.
An oral tumor model has been developed in inbred Syrian golden hamsters by continuous applications every 2 weeks of methyl(acetoxymethyl)nitrosamine [(DMN-OAC) CAS: 56856-83-8; methylnitrosaminomethyl ester acetic acid] at 2 mg/kg body weight alone or by a single application of DMN-OAC followed by continuous twice weekly applications of 12-O-tetradecanoylphorbol 13-acetate (TPA) (1 microgram/animal). Similar studies were done in the W rat buccal mucosa. In the hamsters treated continuously with DMN-OAC, 100% of the tumors were observed in the cheek pouch; none were observed at other sites. In contrast, in the rats treated similarly, only a 67% tumor incidence was observed, of which only 42% were oral tumors. A promoter effect of TPA was observed in hamster cheek pouch tumors induced by DMN-OAC, whereas rat oral mucosa did not respond to TPA treatment.
D000818:Animals; D002273:Carcinogens; D002610:Cheek; D006224:Cricetinae; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives* / Q000633:toxicity; D009061:Mouth Mucosa / Q000187:drug effects / Q000473:pathology*; D009062:Mouth Neoplasms / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D013755:Tetradecanoylphorbol Acetate
D002273:Carcinogens; C014659:methyl(acetoxymethyl)nitrosamine; D004128:Dimethylnitrosamine; D013755:Tetradecanoylphorbol Acetate