Hypoxanthine and Mcardle disease: a clue to metabolic stress in the working forearm.
Forearm exercise in a patient with myophosphorylase deficiency resulted in abnormally high levels of hypoxanthine in the venous blood. The post-exercise hypoxanthine response may reflect ATP depletion in the muscle and provides a useful screening test in muscle diseases with abnormal energy metabolism.
D000249:Adenosine Monophosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000328:Adult; D005542:Forearm; D006008:Glycogen Storage Disease / Q000378:metabolism*; D006012:Glycogen Storage Disease Type V / Q000378:metabolism*; D006801:Humans; D007042:Hypoxanthines / Q000097:blood / Q000378:metabolism*; D007291:Inosine Monophosphate / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism*; D006005:Phosphorylases / Q000172:deficiency
D007042:Hypoxanthines; D007291:Inosine Monophosphate; D000249:Adenosine Monophosphate; D000255:Adenosine Triphosphate; D006005:Phosphorylases