Chromosomal assignments of genes for trypsin, chymotrypsin B, and elastase in mouse.
The mouse genes for the serine proteases trypsin (Try-1), chymotrypsin B (Ctrb), and elastase (Ela-1) were chromosomally assigned using Southern blot hybridization of mouse X Chinese hamster cell hybrid DNA. cDNA probes for the three genes were hybridized to cell hybrid DNA cleaved with BamHI or HindIII and the segregation of Try-1, Ctrb, and Ela-1 was correlated with the segregation of mouse chromosomes. Try-1 is located on chromosome 6, Ctrb is on chromosome 8, and Ela-1 is on chromosome 15. The three genes fall into three syntenic groups that are conserved in the mouse and human genomes.
D000818:Animals; D005075:Biological Evolution; D002874:Chromosome Mapping; D002918:Chymotrypsin / Q000235:genetics; D004247:DNA / Q000235:genetics; D005796:Genes; D051379:Mice / Q000235:genetics*; D010196:Pancreatic Elastase / Q000235:genetics; D014357:Trypsin / Q000235:genetics
D004247:DNA; D002918:Chymotrypsin; D010196:Pancreatic Elastase; D014357:Trypsin