Bioactivity of imipenem as a function of medium, time, and temperature.
The bioactivity of imipenem at 20 micrograms/ml in various agar and broth media which are commonly used in susceptibility test assays was measured at different storage temperatures over time. Imipenem was found to be more stable at 4 degrees C than at -20 degrees C and least stable in all media at 35 degrees C.
D001419:Bacteria / Q000187:drug effects*; D003470:Culture Media; D015378:Imipenem; D008826:Microbial Sensitivity Tests; D013696:Temperature; D013845:Thienamycins / Q000494:pharmacology*; D013997:Time Factors
D003470:Culture Media; D013845:Thienamycins; D015378:Imipenem