The isotretinoin teratogen syndrome.
Two infants with prominent frontal bossing, hydrocephalus, microphthalmia, and small, malformed, low-set, undifferentiated ears were born to mothers who had taken isotretinoin in the first trimester of pregnancy. A Dandy-Walker malformation, microcephaly, hypertelorism, small ear canals, cleft palate, small mouth, and congenital heart disease were also observed. Isotretinoin is a potent teratogen in man; maternal ingestion early in pregnancy leads to a distinct clinical pattern of anomalies.
D000014:Abnormalities, Drug-Induced / Q000209:etiology* / Q000473:pathology; D000015:Abnormalities, Multiple / Q000139:chemically induced / Q000473:pathology; D005260:Female; D006257:Head / Q000002:abnormalities; D006801:Humans; D007231:Infant, Newborn; D015474:Isotretinoin; D011247:Pregnancy; D013577:Syndrome; D014212:Tretinoin / Q000009:adverse effects*
D014212:Tretinoin; D015474:Isotretinoin