Intraperitoneal penetration of cefotetan.
The intraperitoneal penetration of cefotetan was studied after a 1-g intravenous injection in 25 patients undergoing elective gastrointestinal surgery. Levels of peritoneal fluid were high within 10 min after administration and increased to 44% of the serum levels after 30 min, rising to 115% at 3 h. The mean concentration of cefotetan between 3 and 5 h after administration was 32.3 micrograms/ml. These findings suggest that 1 g of cefotetan administered before abdominal surgery would result in intraperitoneal cefotetan levels necessary to inhibit susceptible pathogens for 5 h or more.
D000328:Adult; D000368:Aged; D001202:Ascitic Fluid / Q000378:metabolism*; D001419:Bacteria / Q000187:drug effects; D015313:Cefotetan; D002513:Cephamycins / Q000378:metabolism* / Q000494:pharmacology; D006207:Half-Life; D006801:Humans; D008875:Middle Aged
D002513:Cephamycins; D015313:Cefotetan