HLA A, B, C and DR antigens in young South African Indians with insulin-dependent diabetes mellitus.
The HLA status of South African Indian insulin-dependent diabetic patients in whom the age of onset of diabetes was under 35 years was compared with that of a group of healthy Indian controls. HLA A, B and C antigens were determined in 68 patients and 760 controls, while DR specificities were determined in 35 patients and 235 controls. The diabetic patients showed a significant increase in the frequencies of HLA B8 (19,1% v. 6,8%; relative risk 3,2; corrected P less than 0,04) and Aw24 (42,6% v. 26,8%; relative risk 2,2; corrected P less than 0,04) antigens compared with controls. HLA DR3 was found to be much more common in patients than in controls (31,4% v. 12,8%; relative risk 3,1; corrected P less than 0,035), but DR3/DR4 heterozygosity was associated with a much greater relative risk (7,25). Among patients of North Indian origin a strong association with DR4 was seen (45,5% v. 9,1% (controls); relative risk 8,3).
D003922:Diabetes Mellitus, Type 1 / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D007194:India / Q000208:ethnology; D013019:South Africa
D006680:HLA Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D000949:Histocompatibility Antigens Class II