In vitro enhancement of adriamycin cytotoxicity in human myeloid leukemia cells exposed to verapamil.
The natural resistance of human chronic myeloid leukemia cells to adriamycin (ADR) was overcome by using the cell membrane modulator verapamil (VRP). The studies were done in vitro. [3H] thymidine incorporation inhibition was used as a measure of cytotoxicity. The results clearly show an increase in the effectiveness of ADR when used along with VRP, which may be due to the changes in the cell membrane brought about by VRP.
D002470:Cell Survival / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects; D004317:Doxorubicin / Q000633:toxicity*; D004357:Drug Synergism; D006801:Humans; D007951:Leukemia, Myeloid / Q000473:pathology* / Q000503:physiopathology; D014700:Verapamil / Q000633:toxicity*
D004317:Doxorubicin; D014700:Verapamil