Immunoscintigraphy and distribution study of experimental tumours using 131I-labelled anti-fibrinogen antibodies.
131I-labelled antibodies to the fragment E of human fibrin, anti-rat fibrinogen, non-immune rabbit IgG and 67Ga-citrate were used for scintigraphy and distribution studies in experimental tumours in rats. The best visualisation was achieved with 131I-labelled anti-rat fibrinogen antibodies at intervals longer than 48 h after administration. Tumour to tissue ratios found in distribution studies performed formed more than 48 h after administration were higher in most examined tissues when using 131I-labelled antibodies than those obtained with 67Ga-citrate.
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000276:immunology*; D005710:Gallium Radioisotopes; D007074:Immunoglobulin G / Q000032:analysis; D007457:Iodine Radioisotopes; D009368:Neoplasm Transplantation; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D012517:Sarcoma, Yoshida / Q000000981:diagnostic imaging*; D014018:Tissue Distribution
D000906:Antibodies; D005338:Fibrin Fibrinogen Degradation Products; D005710:Gallium Radioisotopes; D007074:Immunoglobulin G; D007457:Iodine Radioisotopes; C018543:fibrinogen fragment E