Uterine and cardiovascular effects of fenoterol and hexoprenaline in prostaglandin F2 alpha-induced labor in humans.
The effectiveness of the beta-sympathomimetic drugs in prostaglandin-induced labor in humans is uncertain. To assess and compare their uterine and cardiovascular effects, fenoterol (2.5 micrograms/minute) and hexoprenaline (0.38 micrograms/minute) were alternatively infused for 20 minutes in each of 12 patients having prostaglandin F2 alpha inductions of labor at term. Uterine activity was reduced to less than 29% of the pretreatment value. For similar tocolytic effects, hexoprenaline produced a significantly lesser effect on maternal heart rate than fenoterol (P = .005).
D001794:Blood Pressure / Q000187:drug effects; D015237:Dinoprost; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D005280:Fenoterol / Q000627:therapeutic use*; D005318:Fetal Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006594:Hexoprenaline / Q000627:therapeutic use*; D006801:Humans; D007751:Labor, Induced; D010627:Phenethylamines / Q000627:therapeutic use*; D011247:Pregnancy; D011460:Prostaglandins F / Q000037:antagonists & inhibitors*; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects*
D004983:Ethanolamines; D010627:Phenethylamines; D011460:Prostaglandins F; D005280:Fenoterol; D015237:Dinoprost; D006594:Hexoprenaline