Limited use of chromosomal markers in prenatal diagnosis.
By aid of fluorescent centromere markers in chromosome No. 3 it could be shown that crossing over in a translocation quadrivalent had occurred on two occasions in a father who is carrier of a 3/5 translocation. This case demonstrates that marker chromosomes cannot always be used to trace the parental origin of structurally abnormal chromosomes.
D002503:Centromere; D002900:Chromosomes, Human, 1-3; D003434:Crossing Over, Genetic; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014178:Translocation, Genetic
D005819:Genetic Markers