The vasorelaxant effect of (+/-)-15-deoxy-16-hydroxy-16(alpha/beta)-vinyl-prostaglandin E2 (CL 115, 129) and its methyl ester (CL 115, 347) on the isolated ductus arteriosus preparation.
CL 115, 129 and its methyl ester, CL 115, 347, were studied for their vasorelaxant effects and compared to that of prostaglandin (PG) E2 and its methyl ester on isolated ductus arteriosus (DA) from fetal lambs and rabbits. CL 115, 129 and CL 115, 347 potently relaxed the oxygen-indomethacin constricted ductus in a concentration dependent manner. The threshold concentration was 1 X 10(-12)M and the estimated EC50's (M) were 6.9 X 10(-8) and 4.3 X 10(-8), respectively, for CL 115, 129 and CL 115, 347. Also confirmed was the vasorelaxant ability of PGE2. These studies indicate that the CL compounds possess potent vasorelaxant effects on the DA although less potent than PGE2 or its methyl ester.
D000818:Animals; D015232:Dinoprostone / Q000031:analogs & derivatives; D004305:Dose-Response Relationship, Drug; D004373:Ductus Arteriosus / Q000187:drug effects*; D005260:Female; D009126:Muscle Relaxation / Q000187:drug effects; D011247:Pregnancy; D011458:Prostaglandins E / Q000494:pharmacology*; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D011817:Rabbits; D012756:Sheep
D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic; C041324:prostaglandin E2 methyl ester; C034231:15-deoxy-16-hydroxy-16-vinylprostaglandin E2; D015232:Dinoprostone; C034232:viprostol