Effect of daily high doses of paracetamol given orally during spermatogenesis in the rat testes.
Daily treatment of male rats with high doses of Paracetamol (500 mg/kg) during spermatogenesis provokes a significant decrease of testes weight (p is less than 0.001), a significant increase of testicular cytosol glutathione transferase activity ( p is less than 0.02) and of lipid peroxides in the whole homogenate (p is less than 0.01) but not in the microsomes. These alterations could be related to a stimulation of testicular metabolism but cannot produce a biochemical lesion such as glutathione depletion since its testicular content is not modified in these experimental conditions.
D000082:Acetaminophen / Q000633:toxicity*; D000284:Administration, Oral; D000818:Animals; D005978:Glutathione / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects* / Q000378:metabolism
D000082:Acetaminophen; D005978:Glutathione