Effects of chlorpromazine on serotonin uptake in blood platelets.
Platelet serotonin (5-HT) uptake was studied in schizophrenic patients before and after treatment with chlorpromazine (CPZ) for 2-3 weeks. No difference was noted in the affinity of 5-HT (Km) or maximum velocity of 5-HT uptake (Vmax) of unmedicated schizophrenic patients and normal controls. Administration of CPZ was associated with a significant increase in Km and Vmax. Specific uptake of 5-HT, at 0.5 microM, was significantly decreased in most subjects. Chlorpromazine inhibited 5-HT uptake into platelets from normal controls in vitro (IC50, 1.8 +/- 0.1 microM) in a competitive manner.
D000328:Adult; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002746:Chlorpromazine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy; D012701:Serotonin / Q000097:blood*
D012701:Serotonin; D002746:Chlorpromazine