Short-term effects of local anaesthetic agents on the structure of the rat tympanic membrane.
Topical agents used in office procedures for tympanic membrane anaesthesia have been considered to cause damage to the membrane. Four different anaesthetic agents have been compared as regards their histopathological effects for a period of up to 2 weeks after application. An etching effect is obvious when using these clinically potent agents, but it seems reversible and does not leave remaining structural changes.
D000336:Aerosols; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D003042:Cocaine / Q000494:pharmacology; D004338:Drug Combinations / Q000494:pharmacology; D008012:Lidocaine / Q000494:pharmacology; D008297:Male; D008610:Menthol / Q000494:pharmacology; D010636:Phenols / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012996:Solutions; D013997:Time Factors; D014432:Tympanic Membrane / Q000187:drug effects*
D000336:Aerosols; D000779:Anesthetics, Local; D004338:Drug Combinations; D010636:Phenols; D012996:Solutions; D008610:Menthol; C045413:Bonain's liquid; D008012:Lidocaine; D003042:Cocaine