Acute nonlymphocytic leukemia and acute aplastic anemia. The simultaneous occurrence in marital partners.
A young husband and wife couple presented simultaneously with aplastic anemia and acute myelomonocytic leukemia, respectively. No etiologic agent or exposure was identified. With appropriate therapy, the wife achieved a complete remission and the husband has had a good response. Potential etiologic environmental factors known to cause both disorders are discussed. A single causative agent may induce stem-cell changes in genetically dissimilar persons and produce a spectrum of pathologic features ranging from aplastic anemia to acute leukemia.
D000328:Adult; D000741:Anemia, Aplastic / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D000818:Animals; D000961:Antilymphocyte Serum / Q000627:therapeutic use; D002415:Cats; D003561:Cytarabine / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics*; D008297:Male; D008393:Marriage; D013997:Time Factors
D000961:Antilymphocyte Serum; D003561:Cytarabine; D004317:Doxorubicin