Neutrophil chemi-luminescence and opsonic activities of young people with periodontitis in Thailand.
The polymorphonuclear neutrophils (PMN) produced significantly-higher chemi-luminescence (CL) peak values than neutrophils of healthy-paired controls when each population of cells was challenged with zymosan pre-opsonized with autologous serum. This enhanced CL was not attributable to the metabolic activity of the cells, but was shown, by cross-over experiments and additional testing with a single source of cells, to be directly associated with the opsonizing capacity of the patient's serum. The results suggest that peripheral PMN from young periodontitis patients have oxidative metabolic activities similar to subjects free of this disease, and that the enhanced PMN metabolism of patients may be due to a corresponding increase of serum opsonins.
D000328:Adult; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D008163:Luminescent Measurements; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D009895:Opsonin Proteins; D010518:Periodontitis / Q000503:physiopathology*; D010587:Phagocytosis; D013997:Time Factors; D015054:Zymosan
D009895:Opsonin Proteins; D015054:Zymosan