Prostaglandin D2 stimulates secretion of luteinizing hormone from pituitary gland in vitro.
The effect of prostaglandin D2 on the release of luteinizing hormone was studied in a superfusion system by superfusing human pituitary gland. Perfusion with 30 micrograms of prostaglandin D2 induced a significant increase of luteinizing hormone secretion. This is the first evidence of a direct effect of prostaglandin D2 on the secretion of luteinizing hormone from the human pituitary gland. This finding suggests the possible role of prostaglandin D2 in human reproductive function.
D000328:Adult; D005260:Female; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D010902:Pituitary Gland / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism; D015230:Prostaglandin D2; D011457:Prostaglandins D / Q000494:pharmacology*
D011457:Prostaglandins D; D011388:Prolactin; D007986:Luteinizing Hormone; D015230:Prostaglandin D2