CpG frequency in large DNA segments.
The relationship between the deficiency of CpG dinucleotides and the coding-noncoding segments of DNA has been examined. Analysis of five human alpha-like globin DNA sequences and five human beta-like globin DNA sequences reveal that there is no apparent difference between protein coding and non-coding portions of DNA. Rather CpG deficiency appears to be a property of long contiguous segments of DNA consisting of several genes and their intergenic regions. Thus we propose that CpG deficiency is not involved with translation or transcription but rather is related to chromosomal constraints.
D000328:Adult; D000818:Animals; D001482:Base Composition; D001483:Base Sequence; D003568:Cytidine Monophosphate / Q000031:analogs & derivatives; D004247:DNA / Q000235:genetics*; D015226:Dinucleoside Phosphates; D005260:Female; D005333:Fetus; D005796:Genes; D005914:Globins / Q000235:genetics*; D006151:Guanosine / Q000031:analogs & derivatives; D006801:Humans; D009154:Mutation; D009841:Oligonucleotides; D011247:Pregnancy
D003568:Cytidine Monophosphate; D004247:DNA; D015226:Dinucleoside Phosphates; D005914:Globins; D006151:Guanosine; D009841:Oligonucleotides; C015772:CpG dinucleotide