Fulminant hepatic failure due to allopurinol.
A 58-year-old Chinese woman was admitted to hospital with a presumed hypersensitivity reaction to allopurinol. Her illness was characterised by high fever, eosinophilia, exfoliative dermatitis and jaundice. She developed fulminant hepatic failure and septicemia with a fatal outcome. Clinical details are presented and the possible relationship of allopurinol hypersensitivity to renal impairment is discussed.
D000493:Allopurinol / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000150:complications; D005260:Female; D006501:Hepatic Encephalopathy / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008875:Middle Aged
D000493:Allopurinol