Localization of cloned mouse chromosome 7-specific DNA to lethal albino deletions.
Mouse chromosome X- and 7-specific DNA fragments have been isolated from a recombinant DNA library enriched for X(7) chromosome sequences. The library was enriched by flow sorting the X(7) chromosome, a derivation of the Cattanach translocation, prior to library construction. A DNA fragment was found to be located in a region deleted in newborn mice doubly heterozygous for the two albino deletions c3H and c6H in chromosome 7. These chromosome-specific DNA fragments will be useful for studying X inactivation spreading in the X-autosome translocation (T(X;7) 1 Ct) and for investigating the developmental effects of the lethal albino deletions.
D000417:Albinism / Q000235:genetics*; D000818:Animals; D001483:Base Sequence; D002872:Chromosome Deletion; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics*; D004274:DNA, Recombinant / Q000032:analysis; D005260:Female; D005804:Genes, Lethal; D006580:Genetic Carrier Screening; D051379:Mice; D008817:Mice, Mutant Strains; D014178:Translocation, Genetic; D014960:X Chromosome
D004274:DNA, Recombinant; D004247:DNA