Phase-shifts of apparent circadian rhythms due to west and east transmeridian flights or to corresponding night-shift sleep displacements.
Phase movements of apparent circadian rhythms during 2 wk of forward or backward displacement of the sleep-wake cycle were investigated in four experimental series in a subject. The 7-hr delay or advance of sleep due to a westward or an eastward transmeridian flight was duplicated by corresponding sleep displacements during experimental night shifts. Sudden phase advances (or delays) by several hours were observed in the rhythms of continuously recorded rectal temperature and urinary excretion rates (4-hr collection intervals) of adrenaline, noradrenaline and aldosterone the first day after sleep-wake displacement. The desired 7-hr phase-shifts were reached more quickly and completely when the phase was delayed than when it was advanced. In addition, the best-fitting period of these rhythms became shorter than 24 hr when the phase was delayed, and longer than 24 hr when it was advanced. The apparent rhythms of urine flow and electrolyte excretions (potassium, sodium, zinc) were much weaker and their phase movements more irregular than those of hormonal excretion. It is concluded that the sudden phase-shifts resulted from the immediate adaptation of the exogenous components of the rhythms to the demands of the displaced sleep-wake patterns (masking effects) and that the true phase-shifts of the endogenous components followed more slowly and gradually.
D000337:Aerospace Medicine; D001831:Body Temperature; D002940:Circadian Rhythm; D004231:Diuresis; D004837:Epinephrine / Q000378:metabolism; D006801:Humans; D008297:Male; D012890:Sleep / Q000502:physiology*
D004837:Epinephrine