Inhibition of noradrenaline release from hippocampal slices by a stable adenosine analogue.
Electrical field stimulation elicits a calcium-dependent release of 3H-NA from rat hippocampal slices. The release is inhibited by the alpha 2-agonist clonidine and enhanced by the alpha 2-antagonist yohimbine. The stable adenosine analogue N6-L-phenylisopropyl-adenosine (L-PIA) caused a dose-dependent inhibition of 3H-NA overflow. The effect of L-PIA was antagonized by the adenosine receptor antagonist 8-phenyl-theophylline, which caused a slight, but significant increase in overflow per se. The results suggest that there are functionally important presynaptic adenosine receptors on nor-adrenergic nerve terminals in the rat hippocampus.
D000241:Adenosine / Q000031:analogs & derivatives*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D010660:Phenylisopropyladenosine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012636:Secretory Rate / Q000187:drug effects; D013806:Theophylline / Q000031:analogs & derivatives / Q000494:pharmacology
D010660:Phenylisopropyladenosine; D013806:Theophylline; C028322:8-phenyltheophylline; D000241:Adenosine; D009638:Norepinephrine