Expression of erythroid acetylcholinesterase in the K-562 leukemia cell line.
Differentiation-dependent expression of enzyme loci was evaluated in two human leukemic cell lines, the pluripotent leukemia cell line K-562 and the promyelocytic-like cell line HL-60. Acetylcholinesterase, a marker of erythroid differentiation, was present in K-562 cells and absent in HL-60 cells. This difference between the two lines was apparently unrelated to dosage effect; other enzymes carried on trisomic chromosomes in K-562 cells did not show dosage effect. Acetylcholinesterase activity was higher in subclone K-562 (S), which shows higher expression of hemoglobin. Electrophoretic mobility of acetylcholinesterase from K-562 (S) was of fetal type.
D000110:Acetylcholinesterase / Q000097:blood / Q000235:genetics*; D002460:Cell Line; D002871:Chromosome Banding; D002999:Clone Cells; D005260:Female; D005333:Fetus; D006454:Hemoglobins / Q000235:genetics; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000201:enzymology* / Q000235:genetics; D011247:Pregnancy
D006454:Hemoglobins; D000110:Acetylcholinesterase