[Lung scintigraphy after tumor therapy in childhood].
Cytostatics- and radiation-induced alterations of the lung were investigated in 18 children after tumour-therapy by means of lung perfusion scintigraphy. 13 patients (Hodgkin- and non Hodgkin lymphoma, acute lymphocytic leukemia with mediastinal tumour, Ewing-sarcoma, and intrathoracal neuroblastoma) received epidiaphragmatical radiation and cytostatics. All 32 lung-scintigrams of these children 1-23 months after cessation of therapy were pathological. 5 patients (acute lymphocytic leukemia, Histiocytosis X) received cytostatics only. 1-6 months after cessation of therapy in these children 6 lung-scintigrams were pathological, one was normal. After cessation of tumour-treatment scintigraphical improvement of disturbed perfusion occurred in 9/18 patients only. In 6 children a deterioration of lung-perfusion was registered. Lung-scintigraphy is a method for testing pulmonary perfusion in diagnosis and therapy control in childhood malignancies. The results of this study indicate that prophylactic provisions against pulmonary damage during oncologic therapy are necessary.
D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy / Q000532:radiotherapy; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000532:radiotherapy; D008168:Lung / Q000000981:diagnostic imaging*; D008223:Lymphoma / Q000188:drug therapy / Q000532:radiotherapy; D008297:Male; D009447:Neuroblastoma / Q000188:drug therapy / Q000532:radiotherapy; D011832:Radiation Injuries / Q000000981:diagnostic imaging*; D011877:Radionuclide Imaging; D012512:Sarcoma, Ewing / Q000188:drug therapy / Q000532:radiotherapy
D000970:Antineoplastic Agents
Lungenszintigraphie nach Tumortherapie im Kindesalter.