Regional mapping of hexokinase-1 within the short arm of chromosome 10.
Hexokinase-1 (HK1) activity was determined in red cells of 5 patients with partial duplications of chromosome 10, all of which involved the 10p region. In 4 patients the levels of HK1 activity were higher than the mean activity of controls, strongly indicating a triplex dosage effect. The most likely regional assignment for HK1 would appear to be 10p11.2.
D002648:Child; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X / Q000648:ultrastructure*; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005819:Genetic Markers; D006593:Hexokinase / Q000097:blood / Q000235:genetics*; D006801:Humans; D007223:Infant; D008297:Male; D014314:Trisomy
D005819:Genetic Markers; D006593:Hexokinase