Intracellular calcium in essential hypertension. A parameter for assessing effective antihypertensive treatment.
The effects of the loop diuretic piretanide on blood pressure and intra-erythrocytic free Na+ and Ca2+ were examined in 14 essential hypertensives. Intra-erythrocytic Ca2+ activity was found to decrease (P less than 0.01) and Na+ activity to increase (P less than 0.05). In spontaneously hypertensive rats (SHRs) hypovolaemia abolished the humoral transmission of hypertension to normotensive rats. Therefore the decrease in intracellular Ca2+, which may be responsible for the diminished vascular tone under diuretic treatment, could be mediated by a suppression of humoral factors due to diuretic-induced hypovolaemia.
D000328:Adult; D000368:Aged; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D002118:Calcium / Q000097:blood*; D004232:Diuretics / Q000627:therapeutic use*; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy; D008875:Middle Aged; D051381:Rats; D011918:Rats, Inbred SHR; D012964:Sodium / Q000097:blood; D013449:Sulfonamides / Q000627:therapeutic use*
D004232:Diuretics; D013449:Sulfonamides; D012964:Sodium; C015451:piretanide; D002118:Calcium