Translocation (15;17) in a child with variant form of acute promyelocytic leukemia.
We present the cytogenetic and hematologic study of a 6-year-old child with a variant form of acute promyelocytic leukemia (M3) who died of a brain hemorrhage. The brief survival and the hyperleukocytosis (greater than 200,000 mm3) suggests a very bad prognosis in children with this variant form of M3 leukemia.
D001853:Bone Marrow / Q000473:pathology; D002648:Child; D002901:Chromosomes, Human, 13-15; D002902:Chromosomes, Human, 16-18; D014644:Genetic Variation; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008297:Male; D014178:Translocation, Genetic