Fate of Friend leukaemia cells and lymphoma cells injected into mouse blastocysts.
Our aim was to verify whether differentiated murine cells grafted into mouse blastocysts would follow the same fate as teratocarcinoma cells which lose their malignant character and participate in the development of the host embryo yielding chimaeric animals. Two combinations of host embryo-cancer cells were used. Animals were examined after birth or by pregnancy interruption at various stages of development. More than 350 animals obtained from cancer-cells-injected embryos failed to show direct evidence of loss of malignancy.
D000818:Animals; D001755:Blastocyst; D002585:Cesarean Section; D002678:Chimera; D004915:Leukemia, Erythroblastic, Acute / Q000473:pathology*; D008223:Lymphoma / Q000473:pathology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation