The biological activities of phthalate esters on rat gastric muscle.
Monoethylhexyl phthalate, at concentrations that can occur in blood stored in plastic bags (0.1-0.5 mg/ml), reduced contractions of rat isolated gastric fundus to PGE2 and acetylcholine; the diethyl compound was less effective. In contrast, dibutyl phthalate (1 and 10 micrograms/ml) and, to a lesser extent di-isobutyl phthalate, increased the muscle tone. These results are discussed in relation to blood transfusion, and to structural similarities between phthalates and prostaglandins.
D000818:Animals; D003993:Dibutyl Phthalate / Q000494:pharmacology / Q000031:analogs & derivatives; D004051:Diethylhexyl Phthalate / Q000031:analogs & derivatives / Q000494:pharmacology; D015232:Dinoprostone; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010795:Phthalic Acids / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D012601:Scopolamine / Q000494:pharmacology; D013270:Stomach / Q000187:drug effects
D010795:Phthalic Acids; D011458:Prostaglandins E; D003993:Dibutyl Phthalate; D004051:Diethylhexyl Phthalate; D012601:Scopolamine; C016599:mono-(2-ethylhexyl)phthalate; C025605:diisobutyl phthalate; D015232:Dinoprostone