Transferrin subtypes and variants in Germany; further evidence for a Tf null allele.
Isoelectric focusing (IEF) with carrier ampholytes was used for the determination of transferrin C subtypes and transferrin B and D variants in a sample of 1125 unrelated individuals from Southern Germany. The observed TfC allele frequencies were Tf*C1 = 0.7872, Tf*C2 = 0.1365, and Tf*C3 = 0.0675. The rare C subtype C6 was observed twice. A new C subtype, called C10, was observed and identified by IEF with immobilized pH gradients. The rare C subtypes C4 and C8 were also studied by this method. TfB and TfD variants were found with a heterozygous frequency of 1.53%. One new TfD was found which is located between D1 and D2 and therefore named D1-2. Evidence for a Tf null allele was obtained in a child and the putative father; they were considered to be heterozygous for an allele Tf0. The theoretical exclusion rate for paternity examinations was calculated for the Tf system and found to be 17.95%.
D000483:Alleles; D005787:Gene Frequency; D005819:Genetic Markers; D005860:Germany, West; D006801:Humans; D007525:Isoelectric Focusing; D010334:Paternity; D011110:Polymorphism, Genetic; D014168:Transferrin / Q000032:analysis / Q000235:genetics*
D005819:Genetic Markers; D014168:Transferrin