Inflammatory characteristics of platelet activating factor (PAF-acether) in human skin.
The phospholipid PAF-acether is released from a range of inflammatory cell types and, in experimental animals, has properties appropriate to a mediator of inflammation. We have studied the inflammatory characteristics of intradermally injected PAF-acether in human skin. An early weal and flare response was succeeded, in a proportion of subjects, by an area of late-onset erythema at the site of the resolved weal, reminiscent of the dual response to allergen in sensitized individuals. The time-course and dose-response relationship of the early response has been determined and a synergistic interaction between PAF-acether and prostaglandin E2 established. PAF-acether should therefore be considered as a potential mediator of both acute and persisting inflammation in man.
D000328:Adult; D003877:Dermatitis, Contact / Q000503:physiopathology*; D015232:Dinoprostone; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004357:Drug Synergism; D006801:Humans; D007279:Injections, Subcutaneous; D010972:Platelet Activating Factor / Q000031:analogs & derivatives* / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D012867:Skin / Q000187:drug effects* / Q000503:physiopathology
D010972:Platelet Activating Factor; D011458:Prostaglandins E; C026613:1-0-octadecyl 2-0-acetyl sn-glycero-3-phosphorylcholine; D015232:Dinoprostone