Spontaneous tumors of the prostate gland in inbred strains of mice.
Spontaneous tumors of the prostate gland in the house mouse (Mus musculus) have rarely been described. In a histologic survey of prostate glands from old (greater than 700 days of age) mice, we have observed 2 primary adenocarcinomas of the prostate gland, 1 in a 1,047-day-old C57BL/6J mouse (DEH 1009) and 1 with metastases to the kidney and lungs in a 778-day-old C57BL/KsJ mouse (DEH 705C). We have also found a rhabdomyosarcoma of the prostate gland in a C57BL/6J mouse (DEH 1121C) 732 days old. The histologic characteristics of these tumors, and of the prostate glands of mice of similar ages without prostatic neoplastic involvement, including a 736-day-old CBA/CaJ mouse (DEH 849) with adenomatous hyperplasia, are described.
D000230:Adenocarcinoma / Q000473:pathology; D000375:Aging; D000818:Animals; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000473:pathology; D011467:Prostate / Q000254:growth & development; D011471:Prostatic Neoplasms / Q000473:pathology*; D013045:Species Specificity