Non-fertility in cows: influence of PGF, PMSG followed by PGF, progesterone and light.
An injection of PGF-2 alpha into cows at D + 10, D + 12, or at D + 14-15 showed several effects: regression of the corpus luteum in all cases 24 h after the injection, endometrium affected especially at D + 12, and initiation of formation of sorbitol when progesterone was present or of glucuronic acid when oestrogen occurred. Suitable parameters for selecting cows for superovulation, next to a rectal investigation, seem to be a biochemical investigation of cervical mucus on the occurrence of carbohydrates and of abnormal indole- and cholesterol-metabolites. In 'repeat breeders' several deviations were found: a delayed regression of the corpus luteum, a delayed atresia of follicles, a disturbed indole- and carbohydrate-metabolism and no conversion of DHA into oestrogen. Endogenous prostaglandins are apparently not sufficiently effective in a number of these cows and so treatment with PGF, eventually preceded by PMSG, and placing under a fluorescent lamp seemed to be beneficial in six out of eight 'repeat breeders'.
D000818:Animals; D002417:Cattle / Q000502:physiology*; D002582:Cervix Mucus / Q000032:analysis; D015237:Dinoprost; D004971:Estrus / Q000187:drug effects*; D005260:Female; D005298:Fertility / Q000187:drug effects; D006064:Gonadotropins, Equine / Q000494:pharmacology*; D008027:Light; D003341:Luteolysis / Q000187:drug effects; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*
D006064:Gonadotropins, Equine; D011460:Prostaglandins F; D011374:Progesterone; D015237:Dinoprost