Study of competitive binding of gallium and iron by tumor cells.
The influence of iron and gallium carriers on the in vitro and in vivo uptake of 67Ga and 59Fe by tumor cells has been studied. The results appear to indicate that ferritin might be involved in most of the systemic accumulation of 67Ga but that the mechanism of tumor uptake might be different.
D000818:Animals; D001667:Binding, Competitive; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D002951:Citrates / Q000378:metabolism; D019343:Citric Acid; D005708:Gallium / Q000378:metabolism*; D005710:Gallium Radioisotopes / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D007504:Iron Radioisotopes; D051379:Mice; D009374:Neoplasms, Experimental / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000378:metabolism
D002951:Citrates; D005710:Gallium Radioisotopes; D007504:Iron Radioisotopes; D019343:Citric Acid; D005708:Gallium; D007501:Iron