CNS effects of citalopram, a new serotonin inhibitor antidepressant (a quantitative pharmaco-electroencephalography study).
Citalopram, a new phthalane derivative and a specific serotonin re-uptake inhibitor in animal pharmacological tests, was evaluated in a double-blind, crossover, quantitative pharmaco-EEG (QPEEGTM) study in healthy human volunteers. The CNS effects of citalopram are linear, dose- and time-related, can statistically be differentiated from placebo, and indicate a rapid onset of effects with short duration. According to the Computer Data Bank, citalopram has a mode of action similar to mood elevators (antidepressants) with fewer sedative properties. Thus the therapeutic action of citalopram is predicted to be similar to desipramine and protriptyline from the tricyclics, and fluvoxamine from non-tricyclics. According to data bank assessment, it is hypothesized that the single antidepressant dose of citalopram is to be more than 25 mg, which should be given t.i.d. in clinical trials.
D000328:Adult; D000928:Antidepressive Agents; D001921:Brain / Q000187:drug effects*; D015283:Citalopram; D003201:Computers; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004569:Electroencephalography; D006801:Humans; D007099:Imipramine / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology*; D011930:Reaction Time / Q000187:drug effects; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000494:pharmacology
D000928:Antidepressive Agents; D011437:Propylamines; D013876:Thiophenes; D015283:Citalopram; C001750:talsupram; D007099:Imipramine