Protective effects of ketotifen on guinea pig trachea.
We have studied the effects of ketotifen (Ke), an effective antiallergic drug, on guinea pig trachea. Ke (10(-6)-5 X 10(-5) M) inhibits contractions induced in this preparation by acetylcholine, prostaglandin F2 alpha, barium chloride, potassium chloride and electrical stimulation. These results provide evidence for protective effects of Ke in airways. Furthermore, Ke exerts also a neural inhibitory effect on postganglionic parasympathetic fibers of guinea pig trachea. These findings resemble the effects reported previously for disodium cromoglycate by us and might be relevant for antiasthmatic and antiallergic properties of Ke.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001464:Barium / Q000494:pharmacology; D017609:Barium Compounds; D002712:Chlorides; D015237:Dinoprost; D004558:Electric Stimulation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007665:Ketotifen / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D011189:Potassium Chloride / Q000494:pharmacology; D011460:Prostaglandins F / Q000494:pharmacology; D014132:Trachea / Q000187:drug effects / Q000502:physiology*
D017609:Barium Compounds; D002712:Chlorides; D011460:Prostaglandins F; C024986:barium chloride; D001464:Barium; D011189:Potassium Chloride; D015237:Dinoprost; D000109:Acetylcholine; D007665:Ketotifen