Thermoregulatory effects of the specific uptake inhibitor citalopram in maturing mice.
The effects of a single 20 mg/kg dose of citalopram (Lu 10-171) were studied in mice aged 1-10 days. Body temperature measured 2 and 24 hr after treatment was decreased in treated animals as compared with saline injected littermate controls. Two hours after treatment, temperature preference in a thermal gradient was unchanged in animals younger than 6 days; however, in animals 6 days or older, temperature preference was increased as compared with littermate controls. Twenty-four hours after treatment, temperature preference was increased in citalopram-treated animals at all ages tested. The results are discussed in relation to nervous system maturation.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D002490:Central Nervous System / Q000254:growth & development; D015283:Citalopram; D051379:Mice; D011437:Propylamines / Q000494:pharmacology*; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013697:Thermosensing / Q000187:drug effects; D013997:Time Factors
D011437:Propylamines; D012702:Serotonin Antagonists; D015283:Citalopram; D012701:Serotonin