Complementation of the tumorigenic phenotype in human cell hybrids.
Several combinations of human tumor cell lines were fused together. Hybrid populations formed from fusions between carcinoma x carcinoma and carcinoma x lymphoblastoid remained highly tumorigenic. However, suppression of tumorigenic potential was seen in carcinoma x sarcoma and carcinoma x melanoma hybrid populations. These results suggest that complementation of the tumorigenic phenotype can occur and that at least 2 different complementation groups may be involved.
D002277:Carcinoma / Q000235:genetics; D002460:Cell Line; D005816:Genetic Complementation Test; D006367:HeLa Cells / Q000166:cytology; D006801:Humans; D006822:Hybrid Cells / Q000166:cytology*; D007945:Leukemia, Lymphoid / Q000235:genetics; D008545:Melanoma / Q000235:genetics; D009369:Neoplasms / Q000235:genetics* / Q000473:pathology; D010641:Phenotype; D012509:Sarcoma / Q000235:genetics