Homology of adenoviral E3 glycoprotein with HLA-DR heavy chain.
The Mr 19,000 adenovirus glycoproteins coded by the E3 region that is expressed on the cell membrane and presumably binds to HLA class I antigen shows sequence homology to the alpha-chain of human HLA-DR and to the kappa-chain of human IgM. The homology extends to a conserved domain present in all of the major histocompatibility complex antigens, beta 2-microglobulins, and immunoglobulins. Predicted beta-sheet secondary structures are similar between the Mr 19,000 adenovirus protein and these immune system proteins. Evolutionary and functional implications of the homology are discussed.
D000260:Adenoviruses, Human; D000595:Amino Acid Sequence; D000818:Animals; D002462:Cell Membrane / Q000648:ultrastructure; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D046911:Macromolecular Substances; D008970:Molecular Weight; D011487:Protein Conformation; D011506:Proteins; D012984:Software; D013045:Species Specificity; D013329:Structure-Activity Relationship; D014764:Viral Proteins
D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D046911:Macromolecular Substances; D011506:Proteins; D014764:Viral Proteins