Relationships between genes on human chromosome 11 encoding cell-surface antigens.
Genes encoding seven monoclonal antibody-defined cell-surface antigens have been regionally mapped on human chromosome 11, and compared to those of the AL complex defined by polyclonal antibodies using mutational analysis. MIC1, encoding W6/34 antigen, is probably identical to S1, previously mapped to 11pter-p13. MDU1 and MIC8, encoding 4F2 and TRA-1.10 antigens, respectively, are probably identical to S2(a4) and map to 11q13-q22. MIC9, which governs expression of 4D12 and 2E2 antigens, and maps to 11q22-qter, is not related to any of the five AL genes. MIC4 and MIC11, both mapping to 11pter-p13, may have some relationship to S3 and S1, respectively, but identity has not been proven.
D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000235:genetics*; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X; D005796:Genes; D006017:Glycolipids / Q000235:genetics*; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D008970:Molecular Weight; D009154:Mutation
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D006017:Glycolipids; D006023:Glycoproteins