Prevention of N-nitrosobis(2-oxopropyl)amine-induced nasal cavity tumors in rats by orchiectomy.
Bilateral orchiectomy, performed 1 week before initiation of weekly sc injections of N-nitrosobis(2-oxopropyl)amine (BOP), prevented induction of hyperplastic and neoplastic lesions in the nasal and paranasal cavities of outbred Wistar-derived MRC rats. However, in BOP-treated rats without surgery or with bilateral vesiculectomy, the incidences of these lesions were 100 and 90%, respectively. Literature review indicates that nasal and paranasal lesions occur predominantly in male domestic animals as well as in human males and suggests a possible hormone dependency of these lesions.
D000818:Animals; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines; D009669:Nose Neoplasms / Q000139:chemically induced*; D010255:Paranasal Sinus Neoplasms / Q000139:chemically induced; D051381:Rats; D012669:Seminal Vesicles / Q000601:surgery; D013737:Testis / Q000502:physiology* / Q000601:surgery
D009602:Nitrosamines; C013622:nitrosobis(2-oxopropyl)amine