Effect of indomethacin on postsurgical edema in rats.
The effectiveness of intramuscular indomethacin was compared with that of hydrocortisone succinate for the control of edema resulting from experimentally induced surgical trauma in rats. Both drugs produced a significant reduction in tissue water, but no difference could be detected between the effects of the two drugs. These findings indicate the advisability of clinical trials of indomethacin in the control of postsurgical swelling and pain.
D000818:Animals; D004487:Edema / Q000517:prevention & control*; D006854:Hydrocortisone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D007213:Indomethacin / Q000008:administration & dosage / Q000627:therapeutic use*; D007273:Injections, Intramuscular; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D011922:Rats, Mutant Strains
C007133:hydrocortisone hemisuccinate; D006854:Hydrocortisone; D007213:Indomethacin