Formhydroxamic acid-induced malformations of the temporo-mandibular joint.
Formhydroxamic acid was given to pregnant rats in order to produce anomalies of the temporo-mandibular joint. Especially successful in our hands was the dosage of 500-550 mg./kg. given intraperitoneally on day 13. The resulting malformations were very much akin to those seen in human patients.
D000014:Abnormalities, Drug-Induced / Q000473:pathology*; D000818:Animals; D005260:Female; D006877:Hydroxamic Acids / Q000008:administration & dosage / Q000009:adverse effects*; D007569:Jaw Abnormalities / Q000139:chemically induced; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D013704:Temporomandibular Joint / Q000002:abnormalities*
D006877:Hydroxamic Acids; C002903:formohydroxamic acid