Central gastric antisecretory action of prostaglandin E2: the involvement of the pituitary gland.
The mechanism of the gastric antisecretory action of intracerebroventricularly administered prostaglandin (PG)E2 was investigated in conscious, pylorus-ligated rats. It was found that intracerebroventricular administration of 3 micrograms of PGE2 inhibited carbachol-stimulated gastric secretion (acid, pepsin and volume) in vagotomized rats and spontaneous secretion in rats with intact vagi to the same degree. Hypophysectomy prevented the antisecretory effect of PGE2, whereas neither adrenalectomy nor gastric sympathectomy (extirpation of the ganglion coeliacum and mesentericus superius) did modify it. The results suggest that an altered pituitary activity, but not the autonomic nervous system, is involved in the mechanism mediating PGE2-induced inhibitory impulses from the brain on gastric secretion.
D000315:Adrenalectomy; D000818:Animals; D001839:Bombesin / Q000494:pharmacology; D001921:Brain / Q000187:drug effects*; D015232:Dinoprostone; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism*; D007016:Hypophysectomy; D007276:Injections, Intraventricular; D008297:Male; D010902:Pituitary Gland / Q000502:physiology*; D011458:Prostaglandins E / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013562:Sympathectomy; D014628:Vagotomy
D011458:Prostaglandins E; D015232:Dinoprostone; D001839:Bombesin