Congenital acute lymphocytic leukemia in a newborn with Klinefelter syndrome.
A patient with congenital acute lymphocytic leukemia and Klinefelter syndrome is described. The abnormal karyotype appeared in both unstimulated lymphoblasts and stimulated remission lymphocytes. A buccal smear confirmed the presence of extra chromatin material. Klinefelter syndrome has not been described in congenital acute lymphocytic leukemia.
D002874:Chromosome Mapping; D006801:Humans; D007231:Infant, Newborn; D007713:Klinefelter Syndrome / Q000150:complications* / Q000235:genetics; D007945:Leukemia, Lymphoid / Q000150:complications / Q000151:congenital* / Q000235:genetics; D008297:Male