Neutrophil receptor modulation in the pathogenesis of periodontal diseases.
The role of the neutrophil as a primary protective cell in the pathogenesis of periodontal disease has been well established. In this paper, the role of receptor modulation on the neutrophil surface is discussed as a possible mechanism for neutrophil functional abnormalities. Using localized juvenile periodontitis (LJP) as a model, the direct inhibition of neutrophils by bacterial products is discussed as a possible mechanism for local neutrophil dysfunction. In both disease processes, neutrophil receptor modulation plays a central role.
D010520:Aggressive Periodontitis / Q000209:etiology* / Q000276:immunology / Q000382:microbiology; D001419:Bacteria / Q000276:immunology; D018407:Bacterial Physiological Phenomena; D002634:Chemotaxis, Leukocyte; D006801:Humans; D009504:Neutrophils / Q000502:physiology*; D010510:Periodontal Diseases / Q000209:etiology*; D011946:Receptors, Antigen / Q000502:physiology; D011971:Receptors, Immunologic / Q000502:physiology*
D011946:Receptors, Antigen; D011971:Receptors, Immunologic