[Pancreatic and biliary excretion of 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) in man].
For the purpose of examining the transfer of anticancer drug into pancreatic juice and hepatic bile, 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (ACNU) was given to 6 pancreaticoduodenectomized patients with periampullary cancer. The pancreatic juice and bile were collected through the pancreatic or biliary duct drainage before and after the intravenous administration of ACNU (2 mg/kg) for 210 minutes. ACNU concentrations of the pancreatic juice and hepatic bile reached to the maximum 15 minutes and 30 minutes after administration, respectively, and high transfer rates were sustained in both fluids. ACNU concentrations in the hepatic bile were higher than in the pancreatic juice in all cases.
D000328:Adult; D000970:Antineoplastic Agents / Q000378:metabolism*; D001646:Bile / Q000378:metabolism*; D002291:Carcinoma, Papillary / Q000188:drug therapy / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D015376:Nimustine; D009607:Nitrosourea Compounds / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism*; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000378:metabolism
D000970:Antineoplastic Agents; D009607:Nitrosourea Compounds; D015376:Nimustine