[Substances inhibiting monoamine oxidase. II. Inhibition of bovine plasma amine oxidase by N-cyclopropyltryptamines].
In this paper, we report the inhibition constants obtained with N-cyclopropyl-5,6-dimethoxytryptamine and with N-cyclopropyl-6,7-dimethoxytryptamine on the activity of beef plasma amineoxidase. The inhibition constants are respectively: 0.3 x 10(-3) M and 0.65 x 10(-3) M. A dixon graph of the enzymic oxidation of benzylamine indicates a non-competitive inhibition of the enzyme by these dimethoxytryptamines.
D008735:5-Methoxytryptamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D007700:Kinetics; D008996:Monoamine Oxidase Inhibitors; D014363:Tryptamines / Q000494:pharmacology*
D008996:Monoamine Oxidase Inhibitors; D014363:Tryptamines; D008735:5-Methoxytryptamine; C028224:N-cyclopropyl-5,6-dimethoxytryptamine; C028225:N-cyclopropyl-6,7-dimethoxytryptamine
Ricerche su sostanze inibitrici delle monoaminossidasi. Nota II. Inibizione delle aminossidasi da plasma bovino da parte di N-ciclopropiltriptamine.