Statistical analysis of Japanese Thorotrast-administered autopsy cases--1980.
In 193 cases autopsied between 1945 and 1980, all persons who had been intravascularly injected with Thorotrast in life, the authors found 131 malignant hepatic tumors, 20 liver cirrhoses, 6 myeloid leukemias, 4 erythroleukemias, 5 aplastic anemias, 4 lung cancers, 1 mesothelioma and 1 osteosarcoma. The causes of death in the Thorotrast-administered autopsy group (193 cases) were compared with those of a non-Thorotrast-administered autopsy group (95,000 cases) of the same sex and age at death as recorded in the Annals of Japanese Pathological Autopsy cases from 1958 to 1978. This comparison revealed that the frequencies of malignant hepatic tumors, liver cirrhosis, erythroleukemia, and aplastic anemia were significantly higher in the Thorotrast-administered group than in the non-Thorotrast-administered group.
D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000473:pathology; D001859:Bone Neoplasms / Q000473:pathology; D003102:Colloids; D003287:Contrast Media / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007564:Japan; D007953:Leukemia, Radiation-Induced / Q000473:pathology; D008103:Liver Cirrhosis / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology; D008175:Lung Neoplasms / Q000473:pathology; D008223:Lymphoma / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000473:pathology; D009381:Neoplasms, Radiation-Induced / Q000473:pathology; D012516:Osteosarcoma / Q000473:pathology; D011832:Radiation Injuries / Q000473:pathology*; D013911:Thorium Dioxide / Q000009:adverse effects*
D003102:Colloids; D003287:Contrast Media; D013911:Thorium Dioxide