Trichosporon hepatitis.
A 33-yr-old Puerto Rican women was hospitalized for chemotherapy and multiple antibiotic treatment for relapse of acute myelomonocytic leukemia. While she was already receiving amphotericin for suspected Aspergillus infection, she developed hepatomegaly and abnormal liver enzymes with high serum bilirubin. The blood cultures were negative. Percutaneous liver biopsy revealed granulomatous fungal hepatitis identified by cultures as Trichosporon cutaneum. In spite of the continued administration of amphotericin, with the addition of 5-fluorocytosine, Trichosporon was later cultured from her blood, and she succumbed to fungemia and polymicrobial sepsis.
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D001228:Aspergillosis / Q000188:drug therapy; D001706:Biopsy; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use; D006505:Hepatitis / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications*; D008099:Liver / Q000473:pathology; D003904:Mitosporic Fungi / Q000302:isolation & purification; D009181:Mycoses / Q000150:complications* / Q000188:drug therapy; D011247:Pregnancy; D011248:Pregnancy Complications
D000666:Amphotericin B; D005437:Flucytosine