Odontogenic neoplasms in Wistar rats treated with N-methylnitrosourea.
Odontogenic lesions developed in the jaws of six of eighty-one Wistar rats following a single intravenous injection of the alkylating agent, N-methylnitrosourea (MNU). The superficial and deep portions displayed significant differences in both prevailing tissue components and the degree of maturation and induction. In superficial portions, there was a preponderance of well-differentiated mature dental tissues, whereas in deeper portions, nests of less-differentiated, primitive-appearing epithelium predominated. These findings suggest that experimental odontogenic lesions were derived from two distinct sources: surface oral epithelium and enamel organ of the perpetually erupting mandibular incisor tooth. When stimulated by MNU, each source apparently exhibits different potential for odontogenic differentiation.
D000818:Animals; D005260:Female; D007573:Jaw Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D008770:Methylnitrosourea / Q000009:adverse effects*; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D009607:Nitrosourea Compounds / Q000009:adverse effects*; D009808:Odontogenic Tumors / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D009607:Nitrosourea Compounds; D008770:Methylnitrosourea