Role of kidney and adrenals in the humoral pathogenesis of primary hypertension.
In 18 spontaneously hypertensive rats (SHR) of the Münster strain the circulation was connected to that of normotensive animals using the carotid arteries and external jugular veins. The circulations were mixed by a peristaltic pump. In this model the normotensive rats were made hypertensive after a 10-min cross-perfusion cross unidentified humoral factors causing vasoconstriction play an essential role for the development of hypertension in SHRs.
D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D001794:Blood Pressure; D006973:Hypertension / Q000209:etiology* / Q000503:physiopathology; D007668:Kidney / Q000502:physiology*; D009392:Nephrectomy; D010227:Parabiosis; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D013997:Time Factors