Induction of immunological tolerance by oral administration of nickel and chromium.
Oral administration of nickel-chromium to guinea pigs by way of a fixed occlusal splint, or the incorporation of metallic powder or salts into the pelleted food, did not induce hypersensitivity to these metals. In addition, a subsequent attempt to immunize the pre-treated guinea pigs failed in most animals, whereas non-pre-treated guinea pigs became clearly hypersensitive. These results show that oral administration of nickel and chromium induced a state of (partial) tolerance to both metals.
D000284:Administration, Oral; D000818:Animals; D002857:Chromium / Q000008:administration & dosage*; D002858:Chromium Alloys; D003877:Dermatitis, Contact / Q000276:immunology; D004032:Diet; D005260:Female; D005620:Freund's Adjuvant / Q000008:administration & dosage; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000276:immunology* / Q000517:prevention & control; D007108:Immune Tolerance; D007114:Immunization; D007271:Injections, Intradermal; D009532:Nickel / Q000008:administration & dosage*; D012882:Skin Tests
D002858:Chromium Alloys; D002857:Chromium; D009532:Nickel; D005620:Freund's Adjuvant