Acute myelomonocytic leukemia with involvement of eosinophils and inversion of chromosome 16.
A case of acute nonlymphocytic leukemia (ANLL) with abnormal marrow eosinophils is presented. Thorough morphological, cytochemical, and cytogenetic studies confirm the existence of a recently defined new cytogenetic-morphological entity: acute myelomonocytic leukemia with abnormal bone marrow eosinophils (FAB M4), chloracetate esterase- and periodic acid-Schiff-positivity of eosinophilic granules, and pericentric inversion of chromosome 16, in this case combined with trisomy 8. So far 18 such cases have been reported from a single institution. The implications of this new association on the diagnosis of acute leukemia with abnormal eosinophils are discussed.
D000135:Acid Phosphatase / Q000097:blood; D000328:Adult; D002265:Carboxylic Ester Hydrolases / Q000097:blood; D002869:Chromosome Aberrations; D002902:Chromosomes, Human, 16-18; D002906:Chromosomes, Human, 6-12 and X; D003594:Cytoplasmic Granules / Q000201:enzymology; D004804:Eosinophils / Q000201:enzymology / Q000473:pathology*; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000235:genetics*; D008297:Male; D010503:Periodic Acid-Schiff Reaction; D014314:Trisomy
D002265:Carboxylic Ester Hydrolases; C019873:chloroacetate esterase; D000135:Acid Phosphatase