Gallium-67 uptake by the liver: studies using isolated rat hepatocytes and perfused livers.
We studied the hepatic uptake of carrier-free Ga-67 using isolated rat hepatocytes and perfused livers. The results indicate that: (a) the liver can take up Ga-67 and secrete it into the bile, even in the absence of transferrin; (b) transferrin inhibits hepatic uptake of Ga-67 and its biliary excretion; and (c) iron deficiency markedly enhances hepatic uptake of Ga-67.
D000818:Animals; D001646:Bile / Q000378:metabolism; D002478:Cells, Cultured; D003676:Deferoxamine / Q000494:pharmacology; D005710:Gallium Radioisotopes / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D000090463:Iron Deficiencies; D007781:Lactoferrin / Q000494:pharmacology; D008099:Liver / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010477:Perfusion / Q000379:methods; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D014168:Transferrin / Q000378:metabolism / Q000494:pharmacology
D005710:Gallium Radioisotopes; D014168:Transferrin; D007781:Lactoferrin; D003676:Deferoxamine