A study of the in vitro release profile of a new prostaglandin E2 delivery system for local administration in obstetrics.
The in vitro release profile of prostaglandin E2 (PGE2) from a starch polymer hydrogel was studied. Using a diffusion cell apparatus the in vitro release was measured in a cumulative manner based on a steady-state diffusion concept. The results showed that PGE2 was slowly released for a total of 18 hours. The rate of release was constant for up to 2 hours before changing to a lower value for the remaining time period. The PGE2-hydrogel showed sustained release characteristics which could be of significance in the clinical situation in providing a delayed release mechanism.
D004058:Diffusion; D015232:Dinoprostone; D005782:Gels; D007700:Kinetics; D009774:Obstetrics / Q000379:methods*; D011458:Prostaglandins E / Q000008:administration & dosage*; D013213:Starch / Q000031:analogs & derivatives*; D014783:Viscosity
D005782:Gels; D011458:Prostaglandins E; C036577:starch hydrogel copolymer; D013213:Starch; D015232:Dinoprostone