Influence of the peptide chain length of new elongated tuftsin analogs on phagocytosis process.
In this paper the synthesis of the following elongated tuftsin analogs: Arg-Thr-Lys-Pro-Arg (1), Pro-Arg-Thr-Lys-Pro-Arg(II), Lys-Pro-Arg-Thr-Lys-Pro-Arg(III) and Thr-Lys-Pro-Arg-Thr-Lys-Pro-Arg(IV) by classical and solid-phase methods are described. The obtained peptides were tested for their biological activity: restoration of the phagocytosis of defected granulocytes from blood of children with acute lymphoblastic leukemia (ALL).
D002648:Child; D006098:Granulocytes / Q000187:drug effects / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D007945:Leukemia, Lymphoid / Q000503:physiopathology; D010587:Phagocytosis / Q000187:drug effects*; D014405:Tuftsin
D014405:Tuftsin