Comparison of wet and dry aerosol salbutamol.
Wet aerosol and metered dose inhaler (MDI) modes of inhalation of salbutamol were compared in ten asthmatic patients with severe, reversible airways obstruction and in ten chronic bronchitic patients with severe, poorly reversible airways obstruction. The responses to cumulative doses to 800 micrograms (8 x 100 micrograms) by MDI and 10 mg (4 x 0.5 ml of 0.5% standard solution) by wet aerosol were studied. From maximum expiratory flow-volume curves, measurements were made of FEV1, FVC, PEFR, Vmax 50% and Vmax 75%, and pulse and blood pressure responses to cumulative doses of salbutamol were measured. In both groups of patients there was no significant difference between the two modes of inhalation either for each treatment interval or for the maximal response in any of these indices.
D000336:Aerosols; D000420:Albuterol / Q000008:administration & dosage* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000503:physiopathology*; D008176:Lung Volume Measurements; D012996:Solutions
D000336:Aerosols; D012996:Solutions; D000420:Albuterol