Neuromedin K: a novel mammalian tachykinin identified in porcine spinal cord.
A new peptide, designated "neuromedin K" has been discovered and isolated from porcine spinal cord by using bioassays for a tachykinin-like effect on the contractility of smooth muscle preparation from guinea-pig ileum. Porcine neuromedin K has been identified by microsequencing as: Asp-Met-His-Asp-Phe-Phe-Val-Gly-Leu-Met-NH2. The sequence thus determined has been confirmed by synthesis. Neuromedin K has been found to have not only a remarkable sequence homology to kassinin and substance P, but also a prompt stimulant activity on guinea-pig ileum in a manner similar to that of substance P, suggesting that neuromedin K may be involved in neural transmission.
D000595:Amino Acid Sequence; D000818:Animals; D001681:Biological Assay; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects; D015287:Neurokinin B; D009842:Oligopeptides / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D013045:Species Specificity; D013116:Spinal Cord / Q000032:analysis*; D013552:Swine; D014590:Uterine Contraction / Q000187:drug effects
D009842:Oligopeptides; D015287:Neurokinin B