Gingiva as a site for xenobiotic metabolism in rats.
NADPH-dependent N-demethylation of aminopyrine and tripelennamine and hydroxylation of aniline, phenytoin and tripelennamine occurred in rat gingival homogenates. The metabolic profile in gingiva appeared to be similar to that in liver, the major organ in the body for the metabolism of these xenobiotics.
D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D005881:Gingiva / Q000378:metabolism*; D008297:Male; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010672:Phenytoin / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014309:Tripelennamine / Q000378:metabolism
D000814:Aniline Compounds; D004364:Pharmaceutical Preparations; D000632:Aminopyrine; D014309:Tripelennamine; D010672:Phenytoin; C023650:aniline