Genetics of human S-adenosylhomocysteine hydrolase. A new polymorphism in man.
A specific staining procedure for the demonstration of S-adenosylhomocysteine hydrolase (SAHH, EC 3.3.1.1) is given. The enzyme has a broad tissue distribution and is also present in erythrocytes. The SAHH gene is polymorphic in the population of southwest Germany with two common alleles: SAHH*1 = 0.96 and SAHH*2 = 0.04. Family studies resulted in the expected segregation ratios. No evidence for close linkage with a total of 25 marker loci was found. But information from human mouse somatic-cell hybrids led to the localization of the SAHH gene to human chromosome 20, thereby confirming the findings of Hershfield and Francke (1982).
D043383:Adenosylhomocysteinase; D002874:Chromosome Mapping; D002903:Chromosomes, Human, 19-20; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006867:Hydrolases / Q000097:blood / Q000235:genetics*; D008126:Lod Score; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic
D005819:Genetic Markers; D006867:Hydrolases; D043383:Adenosylhomocysteinase