A theory for phase locking of respiration in cats to a mechanical ventilator.
A mathematical model describing the Hering-Breuer reflexes in mechanically ventilated cats is developed. There is good agreement between the properties of the model and experimental studies performed over a wide range of frequencies and volumes of the mechanical ventilator. There is a correspondence between the model and a periodically forced nonlinear oscillator, similar to the van der Pol equation. Brain stem mechanisms underlying the entrainment are discussed.
D000818:Animals; D002415:Cats; D008954:Models, Biological; D010507:Periodicity; D012018:Reflex / Q000502:physiology; D012119:Respiration; D012122:Ventilators, Mechanical