Cochlear pathology with chronically implanted scala tympani electrodes.
In summary, these results with chronic implantation of three types of scala tympani electrode indicate the critical importance of two factors in reducing the risk of additional damage to cochlear structure by implantation surgery: (1) The shape and mechanical characteristics of the array must be precisely controlled such that insertion can be performed with an acceptably low incidence of trauma; and (2) the specific electrode materials and fabrication procedures must be demonstrated to be highly biocompatible in in vivo animal control studies. It appears that the neuronal elements of a prior normal cochlea (in the cat) can withstand chronic implantation of scala tympani electrodes (for at least 1 year) if these two prerequisites are met. The effects of chronic electrical stimulation with these arrays at current levels appropriate for the operation of such devices in patients is not known at present.
D000818:Animals; D001672:Biocompatible Materials; D002415:Cats; D003051:Cochlea / Q000648:ultrastructure*; D003054:Cochlear Implants / Q000009:adverse effects*; D008854:Microscopy, Electron; D009925:Organ of Corti / Q000648:ultrastructure; D011474:Prosthesis Design; D012533:Scala Tympani / Q000293:injuries / Q000648:ultrastructure*; D013136:Spiral Ganglion / Q000648:ultrastructure; D013137:Spiral Lamina / Q000648:ultrastructure; D013997:Time Factors
D001672:Biocompatible Materials