Eosinophilic granulocytes as a possible source of vitamin B12-binding protein.
Leucocyte B12 and B12-binding capacity were measured by Simultrac radioassay in eosinophilic granulocytes, neutrophilic granulocytes and leucocytes obtained from patients with chronic granulocytic and lymphocytic leukaemia. It is shown that (a) eosinophils are a possible source of B12-binding protein similar to neutrophils and (b) granulocytes in myeloproliferative disorders and normal neutrophils have similar B12 and B12-binding capacity indicating that increased B12 and B12-binding capacity in myeloproliferative disorders arise from an increase in myeloid cell turnover.
D004802:Eosinophilia / Q000378:metabolism*; D004804:Eosinophils / Q000032:analysis*; D006801:Humans; D007945:Leukemia, Lymphoid / Q000378:metabolism; D007951:Leukemia, Myeloid / Q000378:metabolism; D008214:Lymphocytes / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000032:analysis; D014155:Transcobalamins / Q000032:analysis*; D014805:Vitamin B 12 / Q000032:analysis
D014155:Transcobalamins; D014805:Vitamin B 12