Leukemia-derived growth factor (non-interleukin-2) produced by murine lymphoma T-cell lines.
Autocrine growth factor activity was found in supernatants of AKR T-cell lymphoma lines cultured in serum-free medium. This factor was designated leukemia-derived growth factor (LDGF). Active supernatants stimulated the growth of the AKR murine T-cell lymphoma line SL 12, its cloned derivatives, and all other murine T-cell lymphoma lines tested. Growth factor activity in conditioned medium was found to be different from interleukin 2 (IL-2) and several other known growth factors. LDGF was able to stimulate growth of the human leukemia T-cells MOLT4f, and the LDGF from MOLT4f cells stimulated the mouse cells. Because mouse T-cell lymphoma lines produced and respond to this factor, it may support the continued proliferation of these cells and could be responsible for their malignant in vivo properties.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004261:DNA Replication / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D007938:Leukemia; D008223:Lymphoma; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D009363:Neoplasm Proteins / Q000302:isolation & purification*; D010455:Peptides / Q000302:isolation & purification* / Q000494:pharmacology / Q000502:physiology; D013045:Species Specificity; D015291:Transforming Growth Factors
D009363:Neoplasm Proteins; D010455:Peptides; D015291:Transforming Growth Factors