Anti-Ia.7 antibodies recognize a "major" idiotype of the anti-TNP antibody response in BALB/c mice.
Monoclonal antibodies to Ia.7 were used, in parallel with other antibodies specific for "major" and "private" idiotopes, to define idiotypic profiles in the primary anti-trinitrophenyl plaque forming cell (PFC) response of BALB/c and C57BL/6 mice. A considerable fraction (25%) of BALB/c but not C57BL/6 PFC were inhibited by anti-Ia.7 antibodies, which failed to inhibit PFC with other paratopic specificities. These results suggest idiotypic mimicry between "major" antibody clonotypes and MHC determinants which might play a role in the selection of antibody repertoires.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000917:Antibody Formation; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology*; D008810:Mice, Inbred C57BL; D009578:Nitrobenzenes / Q000276:immunology*; D014301:Trinitrobenzenes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000949:Histocompatibility Antigens Class II; D007130:Immunoglobulin Idiotypes; D009578:Nitrobenzenes; D014301:Trinitrobenzenes