Inhibition by tuftsin of Rauscher virus leukemia development in mice.
The antitumor effect of tuftsin, the natural phagocytosis-stimulating peptide, on leukemia induced by Rauscher murine leukemia virus (R-MuLV) was studied in vivo in SWR inbred mice. Tuftsin was found capable of significantly increasing the survival of R-MuLV-infected mice. The peptide, when injected both ip and iv into mice, exerted its activity in a dose- and time-dependent manner. Optimal antitumor activity was achieved upon administration of 25 micrograms tuftsin 4 days before R-MuLV inoculation.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D007128:Immunoglobulin Fragments / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007942:Leukemia, Experimental / Q000517:prevention & control*; D051379:Mice; D008815:Mice, Inbred Strains; D011925:Rauscher Virus; D013997:Time Factors; D014405:Tuftsin / Q000494:pharmacology*; D014412:Tumor Virus Infections / Q000517:prevention & control*
D007128:Immunoglobulin Fragments; D014405:Tuftsin