Chronic myeloid leukaemia and the Philadelphia translocation: do the c-sis oncogene and platelet-derived growth factor provide the link?
The study of cellular oncogenes and of chromosomal abnormalities in human tumours has, in several instances, suggested a link between a specific oncogene translocation and oncogenesis. It was recently suggested that the translocation of the c-abl gene (the human cellular homologue of the transforming sequence of Abelson murine leukaemia virus) from chromosome 9 to 22 in Philadelphia translocation, might have a role in the generation of chronic myeloid leukaemia (CML). We propose an alternative hypothesis and suggest that the translocation of another gene, c-sis, may be more important.
D002455:Cell Division; D002478:Cells, Cultured; D002904:Chromosomes, Human, 21-22 and Y; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D007951:Leukemia, Myeloid / Q000209:etiology / Q000235:genetics*; D009857:Oncogenes; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D014178:Translocation, Genetic
D010982:Platelet-Derived Growth Factor