A new method for the determination of steroid sulphatase activity in leukocytes in X-linked recessive ichthyosis.
The diagnosis of X-linked ichthyosis can now be reliably established by using a non-radioactive method to detect steroid sulphatase deficiency in leukocytes. This new method yields the same results with leukocytes as with cultured fibroblasts. The second type of microsomal arylsulphatase previously described in cultured fibroblasts is also present in leukocytes.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001774:Blood Chemical Analysis / Q000379:methods; D002648:Child; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D005808:Genes, Recessive; D006801:Humans; D007057:Ichthyosis / Q000097:blood / Q000235:genetics*; D007962:Leukocytes / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D043266:Steryl-Sulfatase; D013429:Sulfatases / Q000378:metabolism*; D014960:X Chromosome
D013429:Sulfatases; D043266:Steryl-Sulfatase