The isolation of prostaglandin E from pig nasal mucosa.
Prostaglandins of the E series (PGE) have been shown to be potent nasal vasoconstrictors but have not previously been isolated from the nasal mucosa. Here we report the isolation of a biologically active substance with properties similar to PGE from pig nasal mucosa. The substance was identified as PGE on the following criteria: 1 our isolation procedure demonstrated the presence of a biologically active polar acidic lipid; 2 caused contractions of the isolated rat stomach fundic strip similar to PGE2; 3 caused a prolonged nasal vasoconstriction similar to PGE2; 4 travelled on thin layer chromatogram with PGE. The PGE found in the nasal mucosa may have a role in the regulation of mucosal blood flow in normal and pathological conditions.
D000818:Animals; D015232:Dinoprostone; D005748:Gastric Fundus / Q000502:physiology; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009297:Nasal Mucosa / Q000098:blood supply / Q000378:metabolism*; D011458:Prostaglandins E / Q000032:analysis / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D013552:Swine; D014661:Vasoconstriction / Q000187:drug effects
D011458:Prostaglandins E; D015232:Dinoprostone