Complex segregation analysis of Gilles de la Tourette syndrome: further evidence for a major locus mode of transmission.
A sample of 35 published pedigrees of Gilles de la Tourette syndrome is studied using complex segregation analysis with pointers. Results indicate the presence of a rare, semidominant, incompletely penetrant allele leading to affection. This result is consistent with that previously reported by Comings et al. on a larger, independent sample.
D000483:Alleles; D002874:Chromosome Mapping; D005260:Female; D005796:Genes; D006801:Humans; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D011336:Probability; D005879:Tourette Syndrome / Q000235:genetics*