[Effect of arecoline on neuronal activity in the posterior hypothalamus of rabbits with experimental fever].
It has been found in experiments on unanesthetized rabbits that arecoline administered to the lateral ventricle of the brain produced an action which was opposite to that of leukocytic pyrogen. It inhibited the activity of individual neurons of the posterior hypothalamus and decreased the body temperature, with this decrease being attended by the signs of intensified heat emission. Arecoline injection coupled with the central action of PGE2 was followed by an increase in the neuronal activity in the posterior hypothalamus and reduction of hyperthermal response.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001833:Body Temperature Regulation; D015232:Dinoprostone; D005334:Fever / Q000503:physiopathology*; D006979:Hyperthermia, Induced; D007031:Hypothalamus / Q000503:physiopathology*; D007034:Hypothalamus, Posterior / Q000503:physiopathology*; D007375:Interleukin-1; D009474:Neurons / Q000502:physiology*; D011458:Prostaglandins E / Q000494:pharmacology; D011506:Proteins / Q000494:pharmacology; D011817:Rabbits
D007375:Interleukin-1; D011458:Prostaglandins E; D011506:Proteins; C008270:leukocyte endogenous mediator; D015232:Dinoprostone
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