Radiation induced osteosarcoma of the sacrum following radiation of an undiagnosed bone lesion.
Years ago a 20-year-old patient presented with low back pain. Radiologically a cystic lesion of the sacrum was found and interpreted as malignant tumor. Without biopsy and histological diagnosis the patient was given radiation therapy with 21 000 rad. One year later a similar lesion was radiated in the left femoral neck. A pathological fracture ensued recessitating several operations. Twenty years after initial radiation therapy the patient developed a rapidly growing tumor of the sacrum, metastasizing to the lungs. One year later he died.
D000328:Adult; D006801:Humans; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D012516:Osteosarcoma / Q000209:etiology* / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects*; D012447:Sacrum; D013125:Spinal Neoplasms / Q000209:etiology* / Q000473:pathology