Effects of methylmercury chloride on rat incisor odontoblasts and dentinogenesis.
Methylmercury chloride, a well-known nerve cell toxicant, was administered to 40 rats in 2 groups, in doses of 10 mg/kg and 20 mg/kg. Histomorphologic investigation of maxillary incisors after 2 and 4 days revealed granular and hydropic changes in parts of the odontoblastema. Deposition of interglobular dentin was seen after 7 and 11 days. The most vulnerable cells seemed to be the mantle dentin-producing odontoblasts, and the alterations found are probably due to interference with the rough endoplasmic reticulum.
D000818:Animals; D003804:Dentin / Q000187:drug effects / Q000473:pathology; D003810:Dentinogenesis / Q000187:drug effects*; D005260:Female; D007180:Incisor / Q000187:drug effects* / Q000473:pathology; D008767:Methylmercury Compounds / Q000494:pharmacology*; D009804:Odontoblasts / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D008767:Methylmercury Compounds; C004925:methylmercuric chloride