Interaction between manganese and phenobarbital on hexobarbital hypnosis in the male rat.
Pretreatment of male rats with phenobarbital markedly decreases while treatment with manganese prolongs the duration of hexobarbital hypnosis in male rats. When both agents were administered simultaneously, the manganese-induced prolongation of hexobarbital was prevented.
D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D004347:Drug Interactions; D006591:Hexobarbital / Q000378:metabolism / Q000494:pharmacology*; D006991:Hypnosis, Anesthetic; D008297:Male; D008345:Manganese / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats
D008345:Manganese; D006591:Hexobarbital; D010634:Phenobarbital