External imaging of cerebral muscarinic acetylcholine receptors.
A radioiodinated ligand that binds to muscarinic acetylcholine receptors was shown to distribute in the brain by a receptor-mediated process. With single-photon-emission imaging techniques, radioactivity was detected in the cerebrum but not in the cerebellum, whereas with a flow-limited radiotracer, radioactivity was detected in cerebrum and cerebellum. Single-photon-emission computed tomography showed good definition of the caudate putamen and cortex in man.
D000818:Animals; D001923:Brain Chemistry; D002415:Cats; D002421:Caudate Nucleus / Q000032:analysis; D002531:Cerebellum / Q000032:analysis; D004285:Dogs; D006801:Humans; D011699:Putamen / Q000032:analysis; D011812:Quinuclidines / Q000378:metabolism; D011813:Quinuclidinyl Benzilate / Q000378:metabolism / Q000031:analogs & derivatives; D011869:Radioligand Assay; D051381:Rats; D011976:Receptors, Muscarinic / Q000032:analysis* / Q000378:metabolism; D014055:Tomography, Emission-Computed
D011812:Quinuclidines; D011976:Receptors, Muscarinic; C028484:quinuclidinyl benzilate receptor; D011813:Quinuclidinyl Benzilate; C040062:3-quinuclidinyl-4-iodobenzilate