title: Plant anticancer agents XXV. Constituents of Soulamea soulameoides.
abstract: Three simaroubolides, glaucarubolone (1), holacanthone (2), and isobrucein A (3) were found to be responsible for the cytotoxic and antileukemic activities observed for extracts of the wood stem, stem bark, and twigs of Soulamea soulameoides. Other cytotoxic constituents isolated include a coumarinolignan cleomiscosin A (4) and the hydroxy canthin-6-one derivative 5. Picrasin B (6) was also obtained, but was not active.
mesh_terms: D000107:Acetylation; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006868:Hydrolysis; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy
chemical_list: D000972:Antineoplastic Agents, Phytogenic