The antagonistic effects of acetate and lactate upon the trichomonacidal activity of metronidazole.
Lactate and acetate at 5 mM were found to be antagonistic to the killing action of metronidazole on Trichomonas vaginalis under aerobic but not anaerobic conditions. These compounds had no effect on the growth of the parasite, or the rate of metronidazole reduction by, and the activities of NADH oxidase and NADPH oxidase in, parasite homogenates. The phenomenon reported could be one reason why metronidazole is not always effective in the treatment of trichomoniasis.
D000085:Acetates / Q000494:pharmacology*; D007773:Lactates / Q000494:pharmacology*; D019344:Lactic Acid; D008795:Metronidazole / Q000494:pharmacology*; D009097:Multienzyme Complexes / Q000032:analysis; D009247:NADH, NADPH Oxidoreductases / Q000032:analysis; D014246:Trichomonas vaginalis / Q000187:drug effects*
D000085:Acetates; D007773:Lactates; D009097:Multienzyme Complexes; D008795:Metronidazole; D019344:Lactic Acid; C023107:NADH oxidase; D009247:NADH, NADPH Oxidoreductases