title: The microclimate chamber: the effect of continuous topical administration of 96% oxygen and 75% relative humidity on the healing rate of experimental deep burns.
abstract: The healing rate of small experimental burns continuously treated topically with 96% O2 and 75% relative humidity was followed for 25 days. Serial image photographic magnifications (tenfold throughout) of the wounds enabled precise measurements of their size by means of a polar planimeter. Healing rate was expressed as decreased percentile of wound size on a given day compared to the initial area. The mean percentages of healing +/- SEM of the humidified O2 treated wounds on postburn days 6, 11, and 16 were 31.25 +/- 6.15, 82.09 +/- 3.52, and 98.29 +/- 1.46, respectively, and those for the control wounds were 7.08 +/- 2.20, 47.68 +/- 3.39, and 84.41 +/- 1.38, respectively. Analysis of variance revealed highly significant differences in the healing rate between O2-humidity-treated and control wounds (p less than 0.005). The results indicate that topical treatment with 96% O2 and 75% relative humidity improved healing of experimental burns in guinea pigs.
mesh_terms: D000287:Administration, Topical; D000704:Analysis of Variance; D000818:Animals; D002056:Burns / Q000473:pathology / Q000628:therapy*; D002980:Climate; D005260:Female; D006168:Guinea Pigs; D006813:Humidity; D008834:Microclimate; D010100:Oxygen / Q000008:administration & dosage*; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects
chemical_list: D010100:Oxygen