Plasma volume findings in patients with mild pregnancy-induced hypertension.
With the Evans blue dye-dilution technique, plasma volume was serially measured at 29 to 33 weeks' and 34 to 40 weeks' gestation in 74 pregnant women with documented mild pregnancy-induced hypertension (PIH) and 25 well-matched normotensive primigravid women. The relationship of plasma volume to clinical course, perinatal outcome, and other laboratory findings was subsequently analyzed. The patients with mild PIH were categorized into two groups based on infant outcome: appropriate for gestational age (AGA) and small for gestational age (SGA). The mean age, height, and hematocrit of the study and control patients were similar. The group of patients with mild PIH had significantly higher mean arterial blood pressures and uric acid levels (p less than 0.001). There was no difference in mean plasma volume findings between the normotensive group and the mild PIH group delivered of AGA infants. Plasma volume was reduced only in pregnancies with mild PIH with delivery of SGA infants. It is concluded that plasma volume is not reduced in most patients with mild PIH. However, plasma volume might be useful in identifying a subgroup of patients with mild PIH at risk for delivering an SGA infant.
D000328:Adult; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D008657:Metabolic Clearance Rate; D010043:Outcome and Process Assessment, Health Care; D010953:Plasma Volume; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000503:physiopathology*; D011446:Prospective Studies; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid; D003404:Creatinine