Modulating effects of enzymes on T gamma and T mu cells in patients with atopic dermatitis.
Ten patients with moderate to severe atopic dermatitis had increased levels of IgE in the blood and a reduced level of T cells with Fc receptors for IgG (T gamma). After pronase and trypsin digestion of Fc receptors, cultured T cells regenerated the Fc receptors, but preserved the difference between patients and controls. Neuraminidase treatment increased the T gamma-cell level in both patients and controls. Serum from patients with atopic dermatitis could not reduce the T gamma-cell expression in the controls. With regard to Fc receptors, no qualitative difference was observed between patients and controls, but a genuine quantitative difference accounts for the observed reduction of T gamma cells in blood.
D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D003876:Dermatitis, Atopic / Q000276:immunology*; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009439:Neuraminidase / Q000494:pharmacology*; D011402:Pronase / Q000494:pharmacology*; D011961:Receptors, Fc / Q000032:analysis; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D014357:Trypsin / Q000494:pharmacology*
D011961:Receptors, Fc; D007073:Immunoglobulin E; D009439:Neuraminidase; D014357:Trypsin; D011402:Pronase