The metabolism of trans-sobrerol in the rat.
The biotransformation of trans-sobrerol, a potent mucofluidifying agent, has been investigated in rat urine, bile and faeces after single p.o. and i.v. administration. The identification of the isolated metabolites was carried out by g.l.c.-mass spectrometry, n.m.r. and i.r. spectroscopy. The metabolic pathways involve oxidation of the allylic C (sp3) atoms, and mono-beta-glucuronylation of the secondary or tertiary alcoholic group. The mono-beta-glucuronides of sobrerol excreted in bile undergo enterohepatic circulation.
D000284:Administration, Oral; D000818:Animals; D001646:Bile / Q000378:metabolism; D005243:Feces / Q000032:analysis; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D005966:Glucuronidase; D006868:Hydrolysis; D007275:Injections, Intravenous; D051381:Rats; D011919:Rats, Inbred Strains; D013729:Terpenes / Q000378:metabolism*
D013729:Terpenes; C003316:sobrerol; D005966:Glucuronidase