Graft-versus-host reaction induced by spleen grafting in inbred strains of rats. Influence of portal venous drainage.
Acute graft-versus-host (GvH) reaction was induced by spleen grafting in inbred rats. A comparison of the influence of portal or caval drainage of the spleen graft on the survival time was made. This comparison revealed a prolongation of survival time in case of a portal drainage when the graft was an auxiliary half-spleen graft. This result suggests that the liver may have, in some conditions, protective capacities against an acute GvH reaction.
D000818:Animals; D006085:Graft Survival; D006087:Graft vs Host Reaction; D007108:Immune Tolerance; D008099:Liver / Q000276:immunology; D008297:Male; D011169:Portal Vein; D051381:Rats; D011917:Rats, Inbred Lew; D013154:Spleen / Q000098:blood supply / Q000637:transplantation*; D014684:Venae Cavae