Hemoglobin Maputo: a new beta-chain variant (alpha 2 beta 2 47 (CD6) Asp replaced by Tyr) in combination with hemoglobin S, identified by high performance liquid chromatography (HPLC).
During a routine hematological investigation, a slowly-moving hemoglobin variant was detected in a 2-year-old child from Maputo (Mozambique) in combination with hemoglobin S. Structural studies carried out by HPLC demonstrated a previously unreported amino acid substitution, beta 47 (CD6) Asp replaced by Tyr. The new hemoglobin variant has been named hemoglobin Maputo.
D000595:Amino Acid Sequence; D000740:Anemia / Q000097:blood; D055598:Chemical Phenomena; D002621:Chemistry; D002675:Child, Preschool; D014644:Genetic Variation; D006451:Hemoglobin, Sickle; D006455:Hemoglobins, Abnormal / Q000302:isolation & purification*; D006801:Humans; D008297:Male; D009073:Mozambique; D010446:Peptide Fragments
D006451:Hemoglobin, Sickle; D006455:Hemoglobins, Abnormal; D010446:Peptide Fragments; C039479:hemoglobin Maputo