Comparative studies on thrombin inhibitors in experimental microthrombosis.
The influence of thrombin inhibitors, which differ both in their chemical structure and type of inhibition on thrombin-induced microthrombosis was studied in rat lungs. The antithrombotically effective doses and blood levels of the compounds correlated with their kinetic constants for inhibition of thrombin. In preventing microthrombosis, some of the synthetic inhibitors tested surpassed the effectiveness of heparin and approached that of the naturally occurring inhibitor hirudin.
D010129:4-Aminobenzoic Acid / Q000008:administration & dosage; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000097:blood / Q000494:pharmacology; D004151:Dipeptides; D005260:Female; D005340:Fibrinogen / Q000008:administration & dosage; D006629:Hirudins / Q000097:blood / Q000494:pharmacology; D007700:Kinetics; D008168:Lung / Q000378:metabolism / Q000503:physiopathology; D008297:Male; D008833:Microcirculation; D010880:Piperidines / Q000097:blood / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013917:Thrombin / Q000037:antagonists & inhibitors*; D013927:Thrombosis / Q000097:blood*; D062366:para-Aminobenzoates
D004151:Dipeptides; D006629:Hirudins; D010880:Piperidines; D062366:para-Aminobenzoates; C011211:dansyl-arginine-methylpiperidine amide; C015668:4-aminomethylbenzoic acid; C035199:N(alpha)-tosyl-(3-amidinophenyl)alanine piperidide; C038708:N(alpha)-(2-naphthylsulfonylglycyl)-4-amidinophenylalanine piperidide; D005340:Fibrinogen; D001120:Arginine; D013917:Thrombin; D010129:4-Aminobenzoic Acid