The effects of corticosterone, cold exposure and overfeeding with sucrose on brown adipose tissue of obese Zucker rats (fa/fa).
GDP binding to brown-adipose-tissue mitochondria was decreased in obese Zucker rats. Adrenalectomy restored both GDP binding and serum tri-iodothyronine of obese rats to values observed in lean rats. The effects of adrenalectomy on GDP binding and serum tri-iodothyronine were reversed by corticosterone. Decreasing food intake had no effect on brown-adipose-tissue GDP binding in obese rats. Young (5-week-old) obese rats showed a normal increase in brown-adipose-tissue mitochondrial GDP binding after housing at 4 degrees C for 7 days, but this response was attenuated in 10-week-old obese rats. Overfeeding with sucrose increased brown-adipose-tissue thermogenesis in lean, but not in obese, rats. After adrenalectomy, overfeeding with sucrose enhanced brown-adipose-tissue mitochondrial GDP binding in obese rats.
D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D000315:Adrenalectomy; D000818:Animals; D003080:Cold Temperature; D003345:Corticosterone / Q000494:pharmacology*; D006153:Guanosine Diphosphate / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D009765:Obesity / Q000378:metabolism*; D051381:Rats; D011924:Rats, Zucker; D013395:Sucrose / Q000494:pharmacology*; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D006153:Guanosine Diphosphate; D013395:Sucrose; D003345:Corticosterone