Stimulation of ATP hydrolysis by chloroquine and primaquine in human red blood cells.
Primaquine, an 8-aminoquinoline, and chloroquine, a 4-aminoquinoline, both stimulate ATP hydrolysis in human red blood cells incubated in the absence of glucose. In the presence of glucose, ATP levels are partially maintained by increased flux of glucose through glycolysis. Glucose dependence of chloroquine uptake and the activity of primaquine as a redox reagent explain quantitative differences in ATP hydrolysis and accumulation of specific glycolytic products.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000328:Adult; D002738:Chloroquine / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D006868:Hydrolysis; D066298:In Vitro Techniques; D011319:Primaquine / Q000494:pharmacology*; D013268:Stimulation, Chemical
D002738:Chloroquine; D000255:Adenosine Triphosphate; D011319:Primaquine