Effects of macrolide antibiotics on barbiturate sleeping time in mice.
Triacetyloleandomycin and josamycin, when administered to inbred Balb/c mice orally twice daily at a dose of 12.5 or 25 mg per kg over 3 days, were found to increase barbiturate sleeping time significantly. In contrast, erythromycin ethylsuccinate, erythromycin propionate, midecamycin and spiramycin were devoid of any such activity under the same conditions.
D000818:Animals; D004347:Drug Interactions; D005260:Female; D007933:Leucomycins / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010424:Pentobarbital / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors; D014217:Troleandomycin / Q000494:pharmacology*
D007933:Leucomycins; D014217:Troleandomycin; D010424:Pentobarbital