A report of a case of T-cell-derived chronic lymphocytic leukemia with antibodies to adult T-cell leukemia-associated antigens.
A case of T-cell-derived chronic lymphocytic leukemia (T-CLL) with antibodies to adult T-cell leukemia (ATL)-associated antigens (ATLA) is reported. The patient had marked lymphocytosis consisting of peripheral cells that were shown to be T cells by their spontaneous sheep erythrocyte rosette formation and their OKT3 and OKT8 positivity, and in which ATLA were also detected after short-term culture of the cells in vitro. These findings suggest that adult T-cell leukemia virus (ATLV) might cause not only ATL but also some other lymphoid malignancies such as a type of T-CLL as in this case report. Nevertheless the occasional development of OKT8-positive T-CLL in a healthy carrier of ATLV in an ATL-endemic area cannot be disregarded.
D000368:Aged; D000914:Antibodies, Viral / Q000032:analysis*; D006801:Humans; D007938:Leukemia / Q000276:immunology* / Q000473:pathology; D007945:Leukemia, Lymphoid / Q000276:immunology* / Q000473:pathology; D008218:Lymphocytosis / Q000276:immunology / Q000473:pathology; D008223:Lymphoma / Q000276:immunology* / Q000473:pathology; D008297:Male; D012190:Retroviridae / Q000276:immunology*; D012867:Skin / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology
D000914:Antibodies, Viral