title: Myocardial infarct size and cardiogenic shock.
abstract: The relationship between estimated infarct size and cardiogenic shock was investigated in 317 consecutively admitted patients with acute myocardial infarction (AMI). Infarct size was estimated in vivo by serum CK-MB in all patients, and at heart autopsy by histological and histochemical techniques in 23 patients who died in hospital. Although patients with cardiogenic shock (n = 31) had a larger median serum CK-MB estimated infarct size than those without cardiogenic shock (1035 U/l v. 669 U/l, P less than 0.05) there was a substantial overlap in infarct size between the two groups. Heart autopsy confirmed this finding and demonstrated that patients with small subendocardial infarcts also died from shock, especially those with severe 2 or 3 vessel disease and/or infarction fibrosis. Those with cardiogenic shock who survived and those who died from shock had a similar median infarct size, and patients who died from other cardiac causes had the same median infarct size as those who died from shock.
mesh_terms: D000368:Aged; D001706:Biopsy; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D007527:Isoenzymes; D008297:Male; D009203:Myocardial Infarction / Q000175:diagnosis*; D009206:Myocardium / Q000473:pathology*; D012770:Shock, Cardiogenic / Q000150:complications*
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase