Failure of erythromycin in treatment of Legionella micdadei pneumonia.
A 59-year-old immunocompromised woman had nosocomial Legionella micdadei infection that failed to respond to two weeks of erythromycin in high intravenous doses and oral rifampin. Treatment with intravenous trimethoprim-sulfamethoxazole and oral rifampin, which previously has not been used in this infection, resulted in cure.
D004338:Drug Combinations / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D004917:Erythromycin / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007875:Legionella / Q000187:drug effects; D007877:Legionnaires' Disease / Q000188:drug therapy*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D012293:Rifampin / Q000008:administration & dosage; D013420:Sulfamethoxazole / Q000008:administration & dosage; D014295:Trimethoprim / Q000008:administration & dosage; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D004338:Drug Combinations; D004917:Erythromycin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole; D012293:Rifampin