Effect of alloimmunized thymic cells on isolated mouse atria. Participation of prostaglandins.
The effects of thymic cells from alloimmunized mice on the mechanical activity of isolated mouse atria were explored. Immune cells decreased the tension without changing the rate of beating of the atrium. After inhibition of prostaglandin synthesis with indomethacin and acetylsalicylic acid, the negative inotropic action of alloimmunized thymic cells was blocked.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006325:Heart Atria / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology; D007518:Isoantibodies; D051379:Mice; D008807:Mice, Inbred BALB C; D009200:Myocardial Contraction / Q000187:drug effects*; D011738:Pyrilamine / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology*; D013997:Time Factors
D007518:Isoantibodies; D011738:Pyrilamine; D001241:Aspirin; D007213:Indomethacin