[Incorporation of tritium into the DNA of hematopoietic tissues during prolonged administration of tritium oxide].
With long-term (90 days) administration of tritium oxide (0.37 MBq/g body weight) to ras the carbon-bound tritium accumulated in DNA of haemopoietic tissues during two-month administration of the isotope (the accumulation half-time of 15-25 days); during the next month, the isotope level remained nearly constant (about 20 X 10(6) decay/min/g DNA). Elimination of tritium from DNA started 3 days after termination of its administration and proceeded with two half-times (4-8 days and 12-18 days). The ratio of the tritium content per 1 M hydrogen of DNA to tritium content per 1 M hydrogen of tissue water increased up to 0.5-0.7 during the uptake of tritium oxide, and up to 4-7 after the administration of the isotope had ceased.
D000818:Animals; D001853:Bone Marrow / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D008297:Male; D051381:Rats; D013154:Spleen / Q000378:metabolism*; D013950:Thymus Gland / Q000378:metabolism*; D013997:Time Factors; D014316:Tritium / Q000008:administration & dosage / Q000378:metabolism*; D014867:Water / Q000008:administration & dosage
D014867:Water; D014316:Tritium; C033961:tritium oxide; D004247:DNA
Inkorporatsiia tritiia v DNK krovetvornykh tkaneĭ pri dlitel'nom vvedenii okisi tritiia.