Naloxone pretreatment alters the local cerebral metabolic effect of gamma-hydroxybutyrate in rats.
The effect of naloxone on gamma-hydroxybutyrate (GHB)-induced cerebral metabolic depression was studied in rats with the 2-[14C]deoxyglucose method. Naloxone pretreatment statistically significantly antagonized the cerebral metabolic effect of GHB in 10 of 38 structures examined. These results are consistent with previous data showing reversal of the dopaminergic, electroencephalographic, and behavioral effects of GHB by naloxone and suggest that some of the neuropharmacological effects of GHB are mediated by the endogenous opiate system.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D003847:Deoxyglucose; D005947:Glucose / Q000378:metabolism*; D006885:Hydroxybutyrates / Q000037:antagonists & inhibitors*; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D012978:Sodium Oxybate / Q000037:antagonists & inhibitors*
D006885:Hydroxybutyrates; D009270:Naloxone; D012978:Sodium Oxybate; D003847:Deoxyglucose; D005947:Glucose