Modification by cadmium ions of 45calcium uptake by isolated rabbit aortae.
Treatment with 0.5 mM Cd++ suppressed the K+ (30 mM)-stimulated uptake and influx of 45Ca and abolished the K+-induced contraction in helical strips of rabbit aortae. The rapid and slow efflux of 45Ca previously accumulated was not appreciably affected by Cd++. It is concluded that interference with the transmembrane influx of Ca++ is a major mechanism of Cd++ action.
D000818:Animals; D001013:Aorta, Thoracic / Q000502:physiology*; D001692:Biological Transport; D002104:Cadmium / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction; D011188:Potassium / Q000494:pharmacology; D011817:Rabbits
D002104:Cadmium; D011188:Potassium; D002118:Calcium