[Shifts in the steady potential in the dynamics of stationary excitation of the cerebral cortex].
Shifts of steady potentials (SP) in the cerebral cortex of rats were studied during formation of stationary excitation foci by low-frequency electric stimulation and application of penicillin. The dynamics of SP shifts reflects summary effect of depolarization and hyperpolarization processes, actively involved in each cycle of excitation. As a result of functional heterogeneity of different cortical areas, a spontaneously appearing wave of spreading depression (SD) may be transformed into a spiral wave, actively influencing the dynamics of excitation resulting from direct stimulation of the cortex. The cause of long-term inhibition of paroxysmal activity foci may be repeated generation of slow negative waves of SD persisting in conditions of rapid restoration of cortical ability to conduct SD.
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism / Q000502:physiology* / Q000503:physiopathology; D004558:Electric Stimulation; D004594:Electrophysiology; D010406:Penicillins; D010507:Periodicity; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology
D010406:Penicillins; D011188:Potassium
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