Study of HLA antigens in familial and sporadic rheumatoid arthritis.
Patients with familial and non-familial (sporadic) forms of rheumatoid arthritis (RA) were studied to investigate possible HLA heterogeneity. HLA-DR4 was present in 75% of familial and 59% of sporadic RA patients. The frequency distribution of A2, B8, B27, Cw3 and DR3 differed somewhat between the two groups; however, the differences were not statistically significant in this small group of patients. Studies of a larger number of patients are indicated to explore the possibility of genetic subgroups in RA.
D001172:Arthritis, Rheumatoid / Q000235:genetics / Q000276:immunology*; D006680:HLA Antigens; D015789:HLA-A2 Antigen; D015796:HLA-B27 Antigen; D015795:HLA-B8 Antigen; D015236:HLA-C Antigens; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II; D006801:Humans
D006680:HLA Antigens; D015789:HLA-A2 Antigen; D015796:HLA-B27 Antigen; D015795:HLA-B8 Antigen; D015236:HLA-C Antigens; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II