Lipid peroxidation and retinal degeneration.
Retinal degenerations were produced in albino rats by exposure to constant illumination or in frogs and albino rats by intravitreal injections of ferrous sulfate. Both treatments resulted in the loss of long-chain polyunsaturated fatty acids and the accumulation of lipid hydroperoxides in isolated rod outer segments. We suggest that lipid peroxidation is a factor in certain types of retinal degenerations.
D000818:Animals; D005260:Female; D005296:Ferrous Compounds / Q000633:toxicity; D005609:Free Radicals; D008027:Light / Q000009:adverse effects; D008054:Lipid Peroxides / Q000096:biosynthesis*; D011894:Rana pipiens; D051381:Rats; D012162:Retinal Degeneration / Q000209:etiology* / Q000378:metabolism; D012374:Rod Cell Outer Segment / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects
D005296:Ferrous Compounds; D005609:Free Radicals; D008054:Lipid Peroxides; C020748:ferrous sulfate