[Effect of BCG (Bacillus Calmette Guérin) sensitization on the generation of tumor specific killer T cells].
Effector cells of augmented resistance against a syngeneic MC-1 tumor in C57BL/6 mice sensitized with BCG were determined by Winn test, and the following results were obtained: Sensitization of mice with BCG (1.0 mg/mouse) augmented resistance against primary and secondary inoculation of MC-1 tumor. Peritoneal exudate cells of tumor-bearing mice showed a growth-inhibitory activity against MC-1 tumor in Winn test. Sensitization with BCG augmented such an activity of PEC. Augmented resistance was ascribed to a plastic dish-nonadherent, nylon wool column-nonadherent and Thy 1.2-positive cells.
D000818:Animals; D001500:BCG Vaccine / Q000494:pharmacology*; D002455:Cell Division; D007694:Killer Cells, Natural / Q000276:immunology*; D008262:Macrophage Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D012513:Sarcoma, Experimental / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*
D001500:BCG Vaccine