Sleep-promoting effects of endogenous pyrogen (interleukin-1).
When infused into the lateral cerebral ventricles of rabbits, human endogenous pyrogen (EP) preparations induced dose-dependent increases in slow-wave sleep concomitant with increasing body temperature. Heating EP to 70 degrees C destroyed its sleep-promoting and pyrogenic activity. Anisomycin (an antipyretic) prevented EP from increasing body temperature without affecting its sleep-promoting activity. Intravenous injection of EP induced fever and transient increases in slow-wave sleep but failed to induce prolonged increases in slow-wave sleep. We conclude that the somnogenic activity of EP is not secondary to its pyrogenic activity.
D000818:Animals; D000841:Anisomycin / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000502:physiology; D004569:Electroencephalography; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D007700:Kinetics; D008264:Macrophages / Q000502:physiology; D008297:Male; D011817:Rabbits; D012007:Rectum; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors
D007375:Interleukin-1; D000841:Anisomycin