Localization of 1,6-[14C]diaminohexane (HMDA) in the prostate and the effects of HMDA on early gestation in Fischer-344 rats.
Following oral administration of 1,6-[14C]diaminohexane (hexamethylenediamine, HMDA) to male Fischer-344 rats, approx. 20% of the administered dose was recovered as 14CO2 after 72 h. Urinary and fecal excretion accounted for 47% and 27% of the administered radioactivity, respectively. Of several tissues examined, the highest concentrations of residual radioactivity were found in the prostate at 24 and 72 h post-administration. Daily administration of HMDA (200 mg/kg/day) by gavage to pregnant female rats for 2 weeks starting on gestation day 0 did not affect litter size in these animals.
D000818:Animals; D001345:Autoradiography; D002250:Carbon Radioisotopes; D003959:Diamines / Q000378:metabolism* / Q000633:toxicity; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000502:physiology; D008297:Male; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011467:Prostate / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D003959:Diamines; C007297:1,6-diaminohexane