[Toxicity, tolerance and blood concentrations of iron and tylosin with the use of preparation FV-82].
A pharmacologic evaluation was made of a technologic model of a liquid drug form (code name phi B-82), having the following composition: tylosine tartrate 3500000 UI, cyanocobalamine 0.008 g, pyridoxin hydrochloride 0.500 g, tartaric acid 0.100 g, and feridextran (dextrofer-100) up to 100 cm3; pH from 5.5 to 6.5, and Fe3+ 100 mg/cm3. It was found that phi B-82 at i/m application to rabbits, subcutaneous injection to albino mice, and intra-abdominal introduction to albino rats and mice at rates that were equal to ED100 and 3 to 5 times higher than those used with pigs did not lead to local and total lack of tolerance. The acute toxicity (LD50) of phi B-82 at intra-abdominal application to 18-20 g albino mice was 29.2 cm3/kg. The single muscular application to guinea pigs at 2 cm3 per kg of body mass showed good absorption of the preparation - it did not differ essentially from those of dextrofer-100 and aquaous solution of tylosine tartrate used in equivalent amounts. The bacteriostatic concentrations of tylosine were maintained for 24 hours. It was shown that the optimal effect would be produced by a combined preparation having the qualities of the feridextrane complexes with a rapid absorption and those of the erythropoietic vitamins of the B12 group and B6 along with the participation of tylosine as an antibiotic.
D000042:Absorption; D000818:Animals; D004338:Drug Combinations / Q000097:blood / Q000633:toxicity; D004361:Drug Tolerance; D005260:Female; D006168:Guinea Pigs; D007501:Iron / Q000097:blood*; D007505:Iron-Dextran Complex / Q000097:blood / Q000633:toxicity*; D007700:Kinetics; D007928:Lethal Dose 50; D007933:Leucomycins / Q000097:blood / Q000633:toxicity*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011736:Pyridoxine / Q000097:blood / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D015645:Tylosin; D014805:Vitamin B 12 / Q000097:blood / Q000633:toxicity*
D004338:Drug Combinations; D007933:Leucomycins; C039185:FV 82; D007505:Iron-Dextran Complex; D007501:Iron; D011736:Pyridoxine; D014805:Vitamin B 12; D015645:Tylosin
Toksichnost, ponosimost i krŭvni kontsentratsii na zheliazoto i tilozina pri prilagane na preparata FV-82.