title: Metabolism of p-tert.-butyltoluene in the rat and guinea pig.
abstract: The metabolism of p-tert.-butyltoluene (TBT) was studied in the rat and guinea pig. Both the methyl and the tert.-butyl group were oxidized to alcohol and carboxylic acid derivatives in these species. The major urinary metabolites in rats were p-tert.-butylbenzoic acid and its alcohol derivative 2-(p-carboxyphenyl)-2-methylpropan-1-ol whereas p-tert.-butylbenzoylglycine was the most prominent metabolite in guinea pig urine. No significant differences in metabolism were found when TBT was given intragastrically or by inhalation. The intragastric administration of 14C-TBT to rats showed that the bulk of the excretion of radioactivity occurred within three days. A recovery of 83% was achieved and the ratio of urinary/faecal radioactivity was roughly 3.5:1.
mesh_terms: D000818:Animals; D001711:Biotransformation; D008401:Gas Chromatography-Mass Spectrometry; D006168:Guinea Pigs; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D012997:Solvents / Q000378:metabolism* / Q000652:urine; D014050:Toluene / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine
chemical_list: D012997:Solvents; D014050:Toluene; C027647:4-tert-butyltoluene