Synthesis and CNS-depressant profile of 3,4,5-trimethoxybenzoyl analogues.
A series of 3,4,5-trimethoxybenzoyl analogues with varying electronic and stereochemical characteristics has has been synthesized. Many of these compounds (4, 5, 9, 12, 15) showed appreciable potentiation of pentobarbitone-induced hyposis. Several analogues (1, 5, 6, 11, 12, 15) exhibited marked reduction of Spontaneous motor activity (SMA).
D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D002492:Central Nervous System Depressants / Q000138:chemical synthesis*; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D007928:Lethal Dose 50; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010424:Pentobarbital / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects
D000700:Analgesics; D002492:Central Nervous System Depressants; D005707:Gallic Acid; D010424:Pentobarbital