Comparison of three slow-release acetylsalicylic acid preparations in rheumatoid arthritis.
Nine patients suffering from chronic rheumatoid arthritis were each given single doses of 1 g acetylsalicylic acid, in the form of each of the preparations studied: an enteric-coated tablet, a microcrystalline tablet, and a capsule containing enterosoluble granules. Absorption from each preparation was good in all patients. Onset of absorption varied to some degree, but similar salicylate levels were reached within 5 hours with all preparations. In the case of enteric-coated tablets, relatively high salicylate levels persisted 12 hours after dosing, which would seem to permit twice daily dosage, regardless of the total daily dose.
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001241:Aspirin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D002214:Capsules; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D008875:Middle Aged; D013607:Tablets; D013608:Tablets, Enteric-Coated
D002214:Capsules; D003692:Delayed-Action Preparations; D013607:Tablets; D013608:Tablets, Enteric-Coated; D001241:Aspirin