Abnormal leucocyte locomotion induced by haemodialysis membranes. A clue to dialysis leucopenia.
In a study on polymorphonuclear leucocyte (PMN) chemotaxis and random locomotion carried out on 16 patients undergoing haemodialysis and on the same functions in normal PMN which were separated from plasma and subjected to laboratory haemodialysis, it was shown that random PMN locomotion is reduced and that there is a concomitant fall in the leucocyte count in haemodialyzed patients. The laboratory haemodialysis demonstrated that serum factors were not responsible for the PMN dysfunction, which lasted for the entire period of the procedure. The changes were observed only when cellulose membranes were used, and not when haemodialysis was performed with polyacrilonitrile membranes. The reduction in random PMN locomotion may be involved in the genesis of dialysis leucopenia, as well as in the increased susceptibility of uremic patients to infections.
D002465:Cell Movement / Q000187:drug effects; D002482:Cellulose / Q000031:analogs & derivatives / Q000494:pharmacology; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D003176:Complement C3 / Q000096:biosynthesis; D015933:Complement C3d; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D007970:Leukopenia / Q000209:etiology*; D008567:Membranes, Artificial; D009504:Neutrophils / Q000502:physiology*; D006435:Renal Dialysis / Q000009:adverse effects*
D003176:Complement C3; D008567:Membranes, Artificial; C005062:acetylcellulose; D015933:Complement C3d; D002482:Cellulose; C009865:cuprammonium cellulose