2-Chloroacetaldehyde: a metabolite of cyclophosphamide in the rat.
Chloroacetaldehyde has been shown to be a urinary metabolite of cyclophosphamide in the rat. It was identified in the urine of rats given a mixture of [ring C-4, 14C]-cyclophosphamide and [chloroethyl-3H]-cyclophosphamide as its 2,4-dinitrophenyl-hydrazone derivative by its 3H label and by its co-chromatography with chemically synthesised chloroacetaldehyde. The reaction of chloroacetaldehyde with another urinary metabolite of cyclophosphamide is discussed and a nornitrogen mustard adduct postulated. The toxicity of chloroacetaldehyde is also discussed particularly in relation to the urinary bladder.
D000079:Acetaldehyde / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D003520:Cyclophosphamide / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014316:Tritium
D014316:Tritium; D003520:Cyclophosphamide; C004656:chloroacetaldehyde; D000079:Acetaldehyde