Immunosuppression during Trypanosoma musculi infection in inbred strains of mice.
Inbred strains of mice inoculated with T. musculi behaved as either sensitive (A/J, CBA/J and C3H/He/J) or relatively resistant (BALB/c, DBA/2, and C57B1/6) with respect to the magnitude of parasitaemia but not to the length of infection. Spleen cells from T. musculi infected C57B1/6 (resistant) and C3H/HeJ (sensitive) mice inhibited the response of normal spleen cells to PHA and ConA; this suppressive activity was concentrated in T-cells and was higher in the resistant mice. However, infection in T-cell-deprived C57B1/6 and C3H/HeJ mice, although more severe and of much longer duration than in the respective control mice, revealed that T-cells were not responsible for the natural resistance to T. musculi.
D000818:Animals; D007108:Immune Tolerance; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014352:Trypanosomiasis / Q000276:immunology*