Stimulation of cell proliferation by tumor-promoting phorbol esters and inhibition by some inhibitors of tumor promotion in suspension cultures of a human lymphoblastoid cell line.
A human lymphoblastoid cell line, SCC-1, was established from the bone marrow of a patient with acute nonlymphocytic leukemia. 12-O-Tetradecanoylphorbol-13-acetate (TPA) enhanced cell proliferation of SCC-1 cells in suspension culture. A positive correlation was found between the tumor-promoting activities of several plant diterpenes and their enhancing effects on the growth of SCC-1 cells. Various compounds that inhibit tumor promotion were tested for their capacity to inhibit cell proliferation at a physiological concentration. These compounds were not cytotoxic but cytostatic even at high concentration.
D001402:B-Lymphocytes; D001853:Bone Marrow / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured; D004224:Diterpenes / Q000494:pharmacology; D006801:Humans; D007938:Leukemia / Q000473:pathology*; D010704:Phorbols / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D004224:Diterpenes; D010704:Phorbols; D013755:Tetradecanoylphorbol Acetate