Selectively increased adenosine deaminase levels in T cells during typhoid fever.
ADA and PNP levels were measured in T-enriched and T-depleted subpopulations of peripheral mononuclear cells from patients with typhoid fever. ADA activity was significantly increased in T-enriched, but normal in T-depleted preparations of typhoid patients. Elevated levels of ADA in T cells were observed from the initial phase up to 30 days from the onset of the disease. Unlike ADA changes, PNP modifications were transitory, and affected both T-enriched and T-depleted subpopulations. The usefulness of ADA determination in T cells to detect and follow up T-cell activation during typhoid fever is suggested.
D000243:Adenosine Deaminase / Q000378:metabolism*; D006801:Humans; D009700:Nucleoside Deaminases / Q000378:metabolism*; D013601:T-Lymphocytes / Q000145:classification / Q000201:enzymology*; D013997:Time Factors; D014435:Typhoid Fever / Q000097:blood / Q000201:enzymology*
D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase