The acoustic and lateral line nuclei are distinct in the premetamorphic frog, Rana catesbeiana.
The transition from aquatic to terrestrial hearing in the frog occurs during metamorphosis and during the disappearance of the lateral line system. The coincidence in time of these two processes and morphological similarities between the acoustic and lateral line systems has led to the suggestion (Larsell, '34) that the lateral line nuclei are transformed into the acoustic nuclei. The relation between the acoustic and lateral line systems was investigated by studying the distribution of primary afferents, the dendritic patterns of the cells in the primary nuclei, and the development of the nuclei in the premetamorphic bullfrog, Rana catesbeiana. The posterior and anterior lateral line roots distribute to a neuropil located medial to the dorsal medullary nucleus. Horseradish peroxidase (HRP) injections into the contralateral tegmentum fill cells in the periventricular region whose dendrites ramify within the neuropil. These cells constitute the lateral line nuclei. The amphibian and basilar papillary roots of the acoustic system distribute to the more lateral nuclear region. The dendrites of these cells arborize within the nucleus and not in the lateral line neuropil. The dorsal medullary nucleus is, therefore, the acoustic nucleus (AcN). [3H]-thymidine labeling reveals that newly generated cells occupy the AcN within a few hours of their formation throughout the period when anatomical analysis shows the parallel growth and diminution of the lateral line neuropil and nuclei. This study indicates that the lateral line and acoustic systems are morphologically independent at the level of the primary afferents and primary nuclei throughout early development.
D000818:Animals; D001306:Auditory Pathways / Q000254:growth & development; D001307:Auditory Perception / Q000502:physiology*; D001931:Brain Mapping; D007814:Larva; D008526:Medulla Oblongata / Q000254:growth & development*; D011312:Pressure; D011892:Rana catesbeiana; D012679:Sense Organs / Q000294:innervation*; D014726:Vestibular Nuclei / Q000254:growth & development; D000159:Vestibulocochlear Nerve / Q000254:growth & development*