[Reciprocal effect of cyclophosphane on the liver cytochrome P-450 and immunity system].
It has been demonstrated in experiments on mice that administration of cyclophosphamide in a dose of 50 mg/kg for 3 days provokes marked induction of liver cytochrome P-450. However, 5 days after completing cyclophosphamide administration the induction is replaced by inhibition. A similar action under analogous conditions is produced by 3-methylcholanthrene which is widely used as an inductor of cytochrome P-450. The induction of liver cytochrome P-450 by cyclophosphamide or 3-methylcholanthrene is accompanied by pronounced inhibition of immunoreactivity. The known inductor phenobarbital does not produce any reciprocal action. Apparently, the reciprocal action of cyclophosphamide and 3-methylcholanthrene on cytochrome P-450 and immunity is a consequence of intense formation with the involvement of cytochrome P-450 of highly reactive metabolites interfering with the function of immunocompetent cells.
D000818:Animals; D000937:Antigen-Antibody Reactions / Q000187:drug effects*; D003520:Cyclophosphamide / Q000276:immunology / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D007109:Immunity / Q000187:drug effects; D007114:Immunization; D008099:Liver / Q000201:enzymology*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D010634:Phenobarbital / Q000494:pharmacology; D013997:Time Factors
D008748:Methylcholanthrene; D003520:Cyclophosphamide; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital
Retsiproknoe vliianie tsiklofosfana na tsitokhrom P-450 pecheni i sistemu immuniteta.