[Effect of sodium thiosulfate on morphological manifestations of experimental tuberculosis].
The effect of an antioxidant, sodium thiosulphate (in doses of 100 and 150 mg/kg), on morphological manifestations of experimental tuberculosis was studied in 35 white rats. Sodium thiosulphate exerted a marked antiinflammatory and antisclerogenic effect. Changes in morphology (rearrangement of fibrous connective tissue into loose shapeless tissue with increased number of cell elements, mainly lymphocytes, and changes in the structure of collagen fibers down to granular degeneration) and typical properties of the connective tissues (decreased fuxinophilia, decreased content of proteoglycans and glycoproteins, appearance of picrinophilia) were observed in different periods of tuberculosis development which led to a conclusion that sodium thiosulphate not only partially prevented the crude fibrosis formation but also affected the already formed fibrous tissue by its resorption.
D000818:Animals; D000995:Antitubercular Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D008168:Lung / Q000473:pathology; D051381:Rats; D013885:Thiosulfates / Q000627:therapeutic use*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000473:pathology
D000995:Antitubercular Agents; D013885:Thiosulfates; C017717:sodium thiosulfate
Vliianie tiosul'fata natriia na morfologicheskie proiavleniia eksperimental'nogo tuberkuleza.