Distribution and excretion of hexachlorobenzene in bobwhite (Colinus virginianus).
After a single dose of [14C]hexachlorobenzene (HCB) via gavage into the crop, the accumulation of [14C]HCB in female bobwhite (Colinus virginianus) tissues occurred to the greatest extent in adipose tissue followed by skin, liver, brain, heart and kidney, whole blood, and muscle. There was a general relation between increasing HCB concentration and increasing fat content of the tissue. Absorption of [14C]-HCB was rapid with peak radioactivity occurring at 4 h in all tissues except for fat and skin, where it continued to rise until 32 and 16 h after dosing, respectively. Elimination of HCB from tissue was biphasic with phase I representing the combination of HCB excretion and HCB redistribution from tissue into fat stores. Phase II represented solely HCB excretion, which appeared to be a first-order process. The half-life of [14C]HCB in tissues, feces, and eggs ranged from 9-13 d regardless of HCB concentration. Radioactive HCB accumulation in egg yolk was a significant mechanism for the removal of this chemical from bobwhite and accounted for 50% of the total HCB excreted.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D002722:Chlorobenzenes / Q000378:metabolism*; D003088:Colinus / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006581:Hexachlorobenzene / Q000378:metabolism*; D010063:Ovum / Q000378:metabolism; D011784:Quail / Q000378:metabolism*; D012867:Skin / Q000378:metabolism
D002722:Chlorobenzenes; D006581:Hexachlorobenzene