The origin of plasma creatine kinase 1, detected in patients during and following open heart surgery.
Plasma creatine kinase 1 (CK-1) was detected intra-operatively in 6 out of 6 patients and postoperatively in 15 out of 22 patients, undergoing cardiac surgery. A transient increase in plasma levels of creatine kinase 2 (CK-2) and total creatine kinase (CK-tot.) activity was observed in all patients. The disappearance rates for the 2 isoenzymes in the circulation were CK-1: Kd = 4.7 X 10(-3) min-1, and CK-2: Kd = 0.60 X 10(-1) min-3. Analysis of vessel and heart tissue showed that the saphenous vein contained mainly CK-1; high activities of all three isoenzymes were found in the parts of the heart investigated. Most probably, both CK-1 and CK-2 are liberated from injured cardiac tissue.
D001808:Blood Vessels / Q000201:enzymology; D006348:Cardiac Surgical Procedures; D001026:Coronary Artery Bypass; D003402:Creatine Kinase / Q000097:blood*; D006801:Humans; D007432:Intraoperative Period; D007527:Isoenzymes; D009206:Myocardium / Q000201:enzymology; D011184:Postoperative Period; D014656:Vascular Surgical Procedures
D007527:Isoenzymes; D003402:Creatine Kinase