Presence of colony promoting activity (CPA) in the supernatant of the long-term bone marrow cultures.
Colony promoting activity (CPA) was detected in the supernatants of the bone marrow cell cultures. CPA itself had no granulocyte-macrophage colony stimulating activity (CSF); but did increase the number and the size of colonies induced by the optimal dose of CSF. This activity was dose dependent and not specific to CSF sources. CPA-responsive cells (target cells) were found in the bone marrow cell cultures as well as in the freshly isolated bone marrow.
D000818:Animals; D001853:Bone Marrow / Q000502:physiology*; D002455:Cell Division; D003115:Colony-Stimulating Factors / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D006410:Hematopoiesis; D008297:Male; D051379:Mice
D003115:Colony-Stimulating Factors