On the vascular reactivity to angiotensin and noradrenaline in normotensive and spontaneously hypertensive rats.
Vascular reactivity to noradrenaline after angiotensin II and saralasin administration has been studied in vitro on isolated arterial vessels (aorta and mesenteric artery strips) of two strains of normotensive rats and spontaneously hypertensive rats. The results showed: 1. There were no differences in the response to noradrenaline and angiotensin II when they were applied separately on isolated arterial strips of spontaneously hypertensive rats as compared to two strains of normotensive Wistar rats; 2. The potentiated effect of noradrenaline in the presence of angiotensin II is higher on isolated arterial vessels of spontaneously hypertensive rats than on isolated arterial vessels of normotensive rats; 3. The potentiated effect of noradrenaline in the presence of angiotensin II was depressed after administration of angiotensin II-blocker.
D000809:Angiotensins / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects; D006973:Hypertension / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012504:Saralasin / Q000494:pharmacology
D000809:Angiotensins; D012504:Saralasin; D009638:Norepinephrine