title: Glycogenolysis in liver of phosphorylase kinase-deficient rats during liver perfusion and ischaemia.
abstract: Liver glycogen degradation and phosphorylase activity were measured in normal and phosphorylase kinase-deficient (gsd/gsd) rats. During perfusion or ischaemia, gsd/gsd-rat livers showed a brisk glycogenolysis. There was also a small (1.9-fold) but significant transient increase in their phosphorylase alpha activity during ischaemia, despite their phosphorylase b kinase deficiency; it seems unlikely, however, that this was the main determinant of the glycogenolysis.
mesh_terms: D000818:Animals; D005947:Glucose / Q000378:metabolism; D066298:In Vitro Techniques; D007511:Ischemia / Q000378:metabolism; D008099:Liver / Q000098:blood supply / Q000378:metabolism*; D008112:Liver Glycogen / Q000378:metabolism*; D010477:Perfusion; D010764:Phosphorylase Kinase / Q000172:deficiency*; D010762:Phosphorylase a / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D008112:Liver Glycogen; D010762:Phosphorylase a; D010764:Phosphorylase Kinase; D005947:Glucose