[Clinical significance of measurement of immunosuppressive acidic protein (IAP) in lung cancer].
Immunosuppressive acidic protein (IAP) was investigated in 37 patients with lung cancer. A positive rate of IAP in patients was 62.2% and it was higher than that in pulmonary benign diseases except infectious cases. Serum IAP levels increased in accordance with the progress of disease, but no relationship with histological findings was observed. No significant correlation was found between serum IAP levels and in vivo PPD skin test. However, in patients with more than 1000 micrograms/ml of serum IAP levels, higher proportion of patients with negative PPD skin test was observed, indicating the depressed immunity of these patients. From these results, it was suggested that the effects of treatment and prognosis could be predicted by pre-and post-operative IAP levels.
D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000032:analysis; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000097:blood* / Q000276:immunology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000097:blood*; D014374:Tuberculin Test
D002272:Carcinoembryonic Antigen; D009363:Neoplasm Proteins; C030193:immunosuppressive acidic protein