A factor in the culture filtrate of some Klebsiella isolates specifically modifies the fibroblasts of HLA-B27-positive normal individuals.
Cultured skin fibroblasts of HLA-B27-positive clinically normal individuals specifically bind, and are modified by, a factor in the culture filtrate of some Klebsiella isolates. These modified fibroblasts are serologically similar to the cells (lymphocytes and fibroblasts) of B27-positive patients with ankylosing spondylitis (B27+AS+). By contrast, B27+AS+ cells fail to bind the factor, presumably because a receptor present on B27+AS- cells has already been blocked or modified by a Klebsiella antigen in vivo.
D002478:Cells, Cultured; D003470:Culture Media; D005347:Fibroblasts / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis*; D015796:HLA-B27 Antigen; D006801:Humans; D007709:Klebsiella / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D013167:Spondylitis, Ankylosing / Q000276:immunology*
D003470:Culture Media; D006680:HLA Antigens; D015796:HLA-B27 Antigen