Allergenic properties of naturally occurring cannabinoids.
The guinea pig maximization test was used to determine the potential of seven cannabinoids to produce allergic contact dermatitis. delta 9-Tetrahydrocannabinol and cannabinol were found to be extreme (Grade V) sensitizers. Cannabidiol, delta 8-tetrahydrocannabinol, and cannabichromene were moderate (Grade III) sensitizers. Cannabigerol and cannabinol methyl ether were not sensitizers. Most of the cannabinoids were found to be allergenically cross-reactive. Additionally, it was shown that the presence of a free 1'-hydroxyl group was required for sensitization, but not to elicit a response in sensitive animals.
D000485:Allergens; D000818:Animals; D002186:Cannabinoids / Q000276:immunology*; D003429:Cross Reactions; D005260:Female; D006168:Guinea Pigs
D000485:Allergens; D002186:Cannabinoids