Lymphocytes T and pharmacokinetics after a single oral dose of levamisole in healthy and cancer subjects.
Levamisole, an anthelmintic drug with immunopotentiating activity, is shown to have variable effects on cell-mediated immunity. We have studied the effect of a single oral dose (2.5 mg/kg or 5 mg/kg) on early and spontaneous E rosettes percentages in healthy and cancer patients. Pharmacokinetic study of this compound was conducted in parallel. The results indicated that single administration of levamisole (2.5 mg/kg) in healthy men can promote an increase of early E rosettes with mean peak plasma level of 0.8 micrograms. ml-1. On the other hand, there was no change in the proportion of early E rosettes in cancer patients and in the proportion of spontaneous E rosettes in healthy and cancer subjects.
D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D007700:Kinetics; D007978:Levamisole / Q000097:blood / Q000494:pharmacology*; D009369:Neoplasms / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects*
D007978:Levamisole