Parameters of cell-mediated immunity in recurrent herpes simplex.
Cell-mediated immunity was studied by a leukocyte migration inhibition assay, tuberculin, and a DNCB skin test in 32 patients with recurrent herpes simplex infection and in 34 healthy individuals who served as controls. Migration inhibition was found to be significantly reduced in patients who had suffered from recurrences for more than 1 year as compared to the controls. DNCB and tuberculin sensitivity were also found to be impaired in the group with infections of long duration. The data presented suggest a functional defect in cell-mediated immunity in individuals suffering from recurrent herpes simplex which could be responsible for the relapses.
D000328:Adult; D002464:Cell Migration Inhibition; D003877:Dermatitis, Contact; D004137:Dinitrochlorobenzene; D005260:Female; D006558:Herpes Genitalis / Q000276:immunology*; D006801:Humans; D006968:Hypersensitivity, Delayed; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012882:Skin Tests
D004137:Dinitrochlorobenzene