title: Cortical spreading depression and conditioned taste aversion: an attempt to resolve a controversy.
abstract: The claim (Winn, Todd, & Elias, Behav. Biol. 19, 55-63 (1977) ) that cortical spreading depression (CSD) can serve as US in the conditioned taste-aversion (CTA) paradigm was experimentally examined. Rats given 15-min access to novel 0.1% sodium saccharin (CS) followed by ip NaCl and bilateral or unilateral CSD (US) displayed similar saccharin preference (54%) as the sham-CSD-treated controls in a multiple-bottle retention test. Rats receiving ip LiCl (0.15 M, 2% body weight) and sham CSD as the US showed marked saccharin aversion. It is concluded that CSD does not elicit CTA and that some claims to the contrary can perhaps be ascribed to CSD-induced disruption of attenuation of neophobia.
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D003214:Conditioning, Classical / Q000502:physiology; D013181:Cortical Spreading Depression; D003463:Cues; D008297:Male; D051381:Rats; D013649:Taste / Q000502:physiology*