Effects of tri-n-butyl phosphate on the peripheral nervous system of the Sprague-Dawley rat.
Tri-n-butyl phosphate, a widely used plasticizer and solvent, was orally administered to male and female Sprague-Dawley rats for 14 consecutive days (low dose: 0.28 mL/kg; high dose: 0.42 mL/kg). Effects of this industrial chemical were investigated on the peripheral nervous system of these animals. A significant (P less than 0.05) reduction in conduction velocity of caudal nerve was observed in high dose male rats. Electron microscopic examination of sciatic nerve showed morphological changes such as retraction of Schwann cell processes surrounding unmyelinated fibres in both sexes of high dose groups.
D000818:Animals; D005260:Female; D008297:Male; D009431:Neural Conduction / Q000187:drug effects*; D010755:Organophosphates / Q000494:pharmacology*; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D010525:Peripheral Nerves / Q000187:drug effects*; D010968:Plasticizers / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012032:Refractory Period, Electrophysiological / Q000187:drug effects; D012583:Schwann Cells / Q000187:drug effects / Q000648:ultrastructure; D012584:Sciatic Nerve / Q000187:drug effects / Q000648:ultrastructure; D012997:Solvents / Q000633:toxicity*
D010755:Organophosphates; D009943:Organophosphorus Compounds; D010968:Plasticizers; D012997:Solvents; C009524:tributyl phosphate