[Quantification of lectin receptors on B, T, T-gamma and T-mu lymphocytes. I. Concanavalin A, Pisum sativum, Lens culinaris and wheat-germ agglutinin].
The immune system is formed of different lymphocyte subpopulations, each one having a defined role to defend the organism. Their plasma membranes present differences in the glycoproteinic or/and glycolipidic composition, as detected with labelled 125I-lectins. B lymphocytes have a greater number of receptors for the Pisum sativum, Lens culinaris and WGA lectins than T lymphocytes. On the other hand, T lymphocytes bind a greater number of Concanavalin A molecules than B lymphocytes. WGA lectin appeared to be more specific for T mu subpopulation, while Con A and Pisum sativum lectins were bound preferentially to T gamma lymphocytes while no significant differences were observed between both subpopulations for Lens culinaris lectin. From the affinity of each lectin to each lymphocyte population it could be deduced that the receptor structure, conformation and arrangement on the membrane was optimal in B lymphocytes for Con A and WGA binding, and T lymphocytes for Lens culinaris and Pisum sativum binding.
D001402:B-Lymphocytes / Q000032:analysis*; D003208:Concanavalin A / Q000378:metabolism; D006801:Humans; D037102:Lectins / Q000378:metabolism; D037121:Plant Lectins; D011952:Receptors, Concanavalin A / Q000032:analysis; D011975:Receptors, Mitogen / Q000032:analysis*; D013601:T-Lymphocytes / Q000032:analysis*; D014909:Wheat Germ Agglutinins
D037102:Lectins; D037121:Plant Lectins; D011952:Receptors, Concanavalin A; D011975:Receptors, Mitogen; D014909:Wheat Germ Agglutinins; C033619:lentil lectin; C036292:pea lectin; C027503:wheat germ agglutinin receptor; D003208:Concanavalin A
Cuantificación de receptores lectínicos en linfocitos B, T, T gamma y T mu. I. Concanavalina A, Pisum sativum, Lens culinaris y WGA.