[Evaluation of platelet function and coagulation in deafness and sudden vestibular disorders].
Thirty-five patients affected by acute vestibular dysfunction (A.V.D.) and/or sudden deafness (S.D.) were studied. Twenty-seven of them presented, as major component of the clinical disorder, a vestibular dysfunction, eight a sudden deafness. The control group was matched for sex, age, smoking habit and family history of diabetes and myocardial infarction. In all the subjects the following tests were carried out: platelet aggregation (Born's method), PF3 (Spaet and Cintron), PF4 and BTg (RIA), aPTT, AT III, cholesterol and triglycerides. The results indicate in the patients group increase of P.A.: SAV = 27 vs 43% (p = 0.03) at 1.2 X 10(-6) M ADP, a larger availability of PF3 in PPP and PRP, increase of PF4: 7.2 vs 17.2 (p = 0.01) and BTg: 32.4 vs 49.1 (p = 0.009). The data indicate in A.V.D. and S.D. a platelet hyperactivity; if so, an antiplatelet therapy may be reasonable.
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure; D002784:Cholesterol / Q000097:blood; D005260:Female; D003639:Hearing Loss, Sudden / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D007759:Labyrinth Diseases / Q000097:blood / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D010977:Platelet Factor 3 / Q000032:analysis; D010978:Platelet Factor 4 / Q000032:analysis; D014280:Triglycerides / Q000097:blood; D014722:Vestibule, Labyrinth / Q000503:physiopathology*
D001786:Blood Glucose; D014280:Triglycerides; D010977:Platelet Factor 3; D010978:Platelet Factor 4; D002784:Cholesterol
Valutazione della funzionalità piastrinica e della coagulazione nella sordità e nelle turbe vestibolari improvvise.