Carcinogenicity of N-nitroso-acetoxymethyl-methylamine (acetoxymethyl-methylnitrosamine) after inhalation in rats.
Inhalation of nitroso-acetoxymethyl-methylamine (NAMMA) at a mean concentration of 0.5 ppm (= 2.6 mg/m3), 5 h/day, 5 days/week for 7 weeks proved to be highly toxic and carcinogenic in male Sprague-Dawley rats. The first tumour (a carcinoma of the lung) developed after a 14-day period of carcinogen application. The nasal region and the trachea were found to be the main target organs for the local carcinogenic activity.
D000818:Animals; D002273:Carcinogens; D004128:Dimethylnitrosamine / Q000031:analogs & derivatives* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D008175:Lung Neoplasms / Q000139:chemically induced; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; C014659:methyl(acetoxymethyl)nitrosamine; D004128:Dimethylnitrosamine