[Autoimmune and diabetogenic effects of bucarban].
Experiments on animals were made to study the diabetogenous effect of repeated administrations of bucarban. The drug-induced immunization and insulin release were accompanied by the increased immune response of the humoral and cellular types specific for bucarban and insulin as well. The changes in the animals' immune status were accompanied by disorders of carbohydrate and lipid metabolism, characteristic for diabetes mellitus and by a lowering of the hypoglycemic effect of the antidiabetic drug in question. It was shown for the first time that the changes in carbohydrate, lipid and lipoprotein blood indicators seen in the animals given sulfanilamide antidiabetics occur in the presence of intense autoimmune response to the body own insulin and are undoubtedly related to this response.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000139:chemically induced* / Q000276:immunology; D001786:Blood Glucose / Q000032:analysis; D002271:Carbutamide / Q000276:immunology*; D003921:Diabetes Mellitus, Experimental / Q000209:etiology / Q000276:immunology*; D005620:Freund's Adjuvant / Q000008:administration & dosage; D007004:Hypoglycemic Agents / Q000276:immunology* / Q000494:pharmacology; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization; D007330:Insulin Antibodies / Q000032:analysis; D011817:Rabbits; D051381:Rats; D013997:Time Factors
D001323:Autoantibodies; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007330:Insulin Antibodies; D005620:Freund's Adjuvant; D002271:Carbutamide
Autoimmunnyĭ i diabetogennyĭ éffekty bukarbana.