title: [Thymocyte differentiation in mouse embryogenesis].
abstract: Thymocytes in mouse embryogenesis and their capacity for colony formation in the spleen of irradiated mice were studied by electron microscopy and immunoassay. Thymocytes from 13-day-old mouse embryos were found to have large nuclei with diffuse chromatin and 1-2 nucleoli. The cytoplasm of these cells was found to contain ribosomes, mitochondria and Golgi's complex. These lymphocytes possess colony forming capacity and are not lysed by anti-theta-serum. In 15-day-old mouse embryos, theta-antigen shows on the cell surface, while the number of colonies in irradiated recipient' spleens decreases. In 17-day-old embryos, thymocytes acquire the structure and properties common to mature T cells.
mesh_terms: D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D000961:Antilymphocyte Serum / Q000276:immunology; D002454:Cell Differentiation; D003114:Colony-Forming Units Assay; D008214:Lymphocytes / Q000276:immunology / Q000648:ultrastructure; D051379:Mice; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000276:immunology; D013950:Thymus Gland / Q000196:embryology* / Q000648:ultrastructure
chemical_list: D000954:Antigens, Surface; D000961:Antilymphocyte Serum
vernacular_title: Differentsirovka timotsitov v émbriogeneze myshi.