Late relapse from complete remission in nodular and diffuse histiocytic lymphoma.
Twelve patients with unfavorable prognosis lymphomas (diffuse histiocytic lymphoma, 11; nodular histiocytic lymphoma, 1) treated predominantly with radiation therapy, are described in whom relapse of disease occurred late (greater than 2.5 years, 2.8-26 years; median, 6.25 years) after achieving a complete remission. Although relapse probably represented regrowth of clinically quiescent tumor, it is also possible that these were second malignancies, perhaps occurring in a predisposed host. Continued long-term analysis of clinical trials is important to document this uncommon occurrence.
D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008223:Lymphoma / Q000473:pathology / Q000532:radiotherapy*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013997:Time Factors