title: Synthesis and antiinflammatory activity of [(cycloalkylmethyl)phenyl]acetic acids and related compounds.
abstract: [(Cycloalkylmethyl)phenyl]acetic acid derivatives and related compounds were synthesized to test their antiinflammatory and analgesic activities. Some of the compounds in this series were found to have good activity in the carrageenan edema test. Among them, sodium 2-[4-[(2-oxocyclopentyl)methyl] phenyl]propionate dihydrate (15) and 2-[4-[(2-oxocyclohexylidene)methyl]phenyl]propionic acid (13b) showed potent analgesic and antiadjuvant arthritis activities with excellent antipyretic properties.
mesh_terms: D000700:Analgesics; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D005334:Fever / Q000188:drug therapy; D007052:Ibuprofen / Q000627:therapeutic use; D007213:Indomethacin / Q000627:therapeutic use; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D010648:Phenylacetates / Q000138:chemical synthesis / Q000627:therapeutic use*; D010666:Phenylpropionates / Q000627:therapeutic use; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
chemical_list: D000700:Analgesics; D010648:Phenylacetates; D010666:Phenylpropionates; C040375:pelubiprofen; C040656:loxoprofen; D007052:Ibuprofen; D007213:Indomethacin