title: Murine lupus nephritis: effects of cyclophosphamide on circulating and tissue bound immunoreactants.
abstract: We investigated the effects of cyclophosphamide (Cy) on immunoreactants of plasma and kidney of mice with lupus nephritis. Cy therapy decreased plasma concentrations of IgG, but not the concentrations of anti-DNA antibodies, C3, and C1q reactive materials; in glomeruli deposits of immunoreactants were mesangial in location and decreased overall. Although Cy arrested the nephritis of NZB/W mice, the anti-DNA activity in the renal eluates was very low and comparable in untreated and in treated mice. Immune complex systems other than, or in addition to, DNA-anti-DNA are likely to play a role in the pathogenesis and course of murine lupus nephritis.
mesh_terms: D000818:Animals; D000974:Antibodies, Antinuclear / Q000032:analysis; D003166:Complement Activating Enzymes / Q000032:analysis; D015922:Complement C1q; D003176:Complement C3 / Q000032:analysis; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004277:DNA, Single-Stranded / Q000276:immunology; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy / Q000276:immunology*; D007074:Immunoglobulin G / Q000032:analysis; D007678:Kidney Glomerulus / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy / Q000276:immunology; D051379:Mice; D008814:Mice, Inbred NZB
chemical_list: D000974:Antibodies, Antinuclear; D003176:Complement C3; D004277:DNA, Single-Stranded; D007074:Immunoglobulin G; D015922:Complement C1q; D003520:Cyclophosphamide; D003166:Complement Activating Enzymes