title: Familial occurrence of progressive systemic sclerosis and systemic lupus erythematosus.
abstract: Eight families containing one member with progressive systemic sclerosis and another with systemic lupus erythematosus have been encountered. Two individuals had clinical/serologic/postmortem findings of both diseases and familial pairs were generally concordant for serologic features. A general lack of household contact was encountered, and HLA haplotypes were shared in 5 of 6 pairs studied.
mesh_terms: D000974:Antibodies, Antinuclear / Q000032:analysis; D000941:Antigens / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D001324:Autoantigens; D002114:Calcinosis / Q000150:complications; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000235:genetics*; D008297:Male; D012595:Scleroderma, Systemic / Q000150:complications / Q000235:genetics*; D055517:snRNP Core Proteins
chemical_list: D000974:Antibodies, Antinuclear; D000941:Antigens; D001323:Autoantibodies; D001324:Autoantigens; D006680:HLA Antigens; D055517:snRNP Core Proteins