Mammalian skeletal muscle: long-lasting contractures and potentiated tetani produced by conditioning with weak acid anions.
Reversible contractures can be induced in slow mammalian muscles by manipulations that probably generate a long-lasting alkalinization of the muscle cell interior. Such contractures reach about 1/4 of the tetanic force, P0, and last 10 times longer than potassium contractures. While in contracture, the muscle fibers have high resting potentials so that they can be electrically stimulated. Tetanic force is then increased and added to that of the contracture so that total force may reach 2 P0. This level of potentiation has not been reached by any previously-known method.
D000818:Animals; D000838:Anions / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology; D004558:Electric Stimulation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008564:Membrane Potentials; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects*; D011188:Potassium / Q000494:pharmacology; D051381:Rats
D000838:Anions; D002110:Caffeine; D011188:Potassium