Delimitation of the period of sensitivity to the cataractogenic action of selenite in rats.
The period when selenite is able to induce cataracts begins on the 2nd and ends on the 17th day of postnatal life. Higher doses of selenite do not change the beginning of the cataractogenic period but may induce rare cataracts (up to 17%) when given on the 18th and 19th day of life. The lethal effect of selenite, which predominantly depends on the administered dose, is significantly lowered during the period of selenite-induced cataractogenesis.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D002386:Cataract / Q000139:chemically induced*; D005333:Fetus / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D020887:Selenious Acid; D012643:Selenium / Q000633:toxicity*
D020887:Selenious Acid; D012643:Selenium