Mechanism of resistance to some cephalosporins in Staphylococcus aureus.
The mechanism of resistance to some cephalosporins in Staphylococcus aureus strains was investigated with high-pressure liquid chromatography and nuclear magnetic resonance spectrometry. Drug inactivation by penicillinase was found to be the main mechanism of resistance to cefazolin, cephaloridine, and cephalothin in S. aureus.
D002511:Cephalosporins / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D010405:Penicillinase / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*
D002511:Cephalosporins; D010405:Penicillinase