Molecular cloning and nucleotide sequence of a transforming gene detected by transfection of chicken B-cell lymphoma DNA.
A transforming gene detected by transfection of chicken B-cell lymphoma DNA has been isolated by molecular cloning. It is homologous to a conserved family of sequences present in normal chicken and human DNAs but is not related to transforming genes of acutely transforming retroviruses. The nucleotide sequence of the cloned transforming gene suggests that it encodes a protein that is partially homologous to the amino terminus of transferrin and related proteins although only about one tenth the size of transferrin.
D000818:Animals; D001402:B-Lymphocytes; D001483:Base Sequence; D002471:Cell Transformation, Neoplastic; D002645:Chickens; D003001:Cloning, Molecular; D004273:DNA, Neoplasm / Q000235:genetics*; D008223:Lymphoma / Q000235:genetics*; D009374:Neoplasms, Experimental / Q000235:genetics; D014162:Transfection; D014168:Transferrin / Q000235:genetics
D004273:DNA, Neoplasm; D014168:Transferrin