[Characteristics of the rhythmic activity of a normal and a damaged heart during hyperactivity of spinal cord preganglionic neurons].
Experiments on white rats were made to investigate the character of rhythmical activity of normal heart and that in acute myocardial ischemia in response to electrical stimulation of preganglionic neurons (PN) of the thoracic part of the spinal cord and the formation in them of the generator of pathologically enhanced excitation induced by microinjection of tetanus toxin. In both types of PN hyperactivation, arrhythmias of different patterns developed, their severity and duration being related to the level of initial cardiac reactivity and the degree of PN excitation. It is suggested that under distress of the autonomous mechanisms responsible for regulation of the injured heart, hyperactivation of the spinal cord sympathetic apparatus might be a factor provoking arrhythmia.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology*; D001339:Autonomic Fibers, Preganglionic / Q000187:drug effects / Q000502:physiology*; D003327:Coronary Disease / Q000503:physiopathology*; D004558:Electric Stimulation; D006321:Heart / Q000502:physiology* / Q000503:physiopathology; D008297:Male; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology*; D013744:Tetanus Toxin / Q000494:pharmacology
D013744:Tetanus Toxin
Kharakter ritmicheskoĭ deiatel'nosti zdorovogo i povrezhdennogo serdtsa pri giperaktivnosti preganglionarnykh neĭronov spinnogo mozga.