Primary in vivo T cell reactivity of NZB grafts in H-2 identical allogenic hosts.
By means of the Simonson GVH-assay and the popliteal lymph node (PLN) assay, the T-cell reactivity of NZB mice against H-2 identical allogenic cells was investigated in vivo and compared to that of normal mice. None of the normal mice did react, but a highly significant NZB response could be demonstrated, which did not depend on differences in Mls antigens. These in vivo results extend previous findings of a T-cell hyperreactivity of NZB mice in primary in vitro reactions. They favour the possibility that the T-cell hyperreactivity might be relevant in vivo in facilitating autoimmune responses.
D000818:Animals; D001327:Autoimmune Diseases / Q000276:immunology; D006087:Graft vs Host Reaction; D006183:H-2 Antigens / Q000276:immunology*; D007700:Kinetics; D008099:Liver / Q000033:anatomy & histology; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008814:Mice, Inbred NZB; D009929:Organ Size; D013154:Spleen / Q000033:anatomy & histology; D013601:T-Lymphocytes / Q000276:immunology*
D006183:H-2 Antigens