Learning impairment in mice following acute exposure to dichloromethane and carbon tetrachloride.
Mice were exposed via inhalation to high concentrations of either dichloromethane (168 mg/l) or carbon tetrachloride (134.3 mg/l). The mice were tested for learning ability using a passive-avoidance conditioning task. Exposed animals were found to have a significantly decreased ability to learn when compared with controls. The 3-wk-old mice were more affected than the 5-wk-old and the 8-wk-old mice. The exposed animals were indistinguishable from controls in terms of motor activity, weight gain, and absence of analgesia.
D000367:Age Factors; D000698:Analgesia; D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D002251:Carbon Tetrachloride / Q000633:toxicity*; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D007858:Learning / Q000187:drug effects*; D008297:Male; D008752:Methylene Chloride / Q000633:toxicity*; D051379:Mice; D011930:Reaction Time / Q000187:drug effects
D006843:Hydrocarbons, Chlorinated; D008752:Methylene Chloride; D002251:Carbon Tetrachloride