title: [Circadian rhythm of ventilatory parameters of intrinsic asthma in clinical remission].
abstract: In six subjects with intrinsic asthma in clinical remission, time-structure of ventilatory parameters has been evaluated in order to evaluate: 1) which indexes present statistically significant circadian fluctuations; 2) if phase-shifts occur in comparison with normal subjects. After a period of synchronization of 7 days (L/D: 07.30-23.00; meal timing at 08.00, 13.00 and 20.30) all subjects have been studied by spirometry, flow-volume loop and Raw determination 6 times in a 24-hr period at constant intervals of 4 hrs. The results have been evaluated by macroscopic and microscopic analysis statistical significant fluctuations have been shown in these functional indexes: MEF50, Raw, SRaw, SGaw, FRC and RV; no phase-shifts occurred in comparison with normal subjects. On the contrary a circadian rhythm has not been shown in FVC, FEV1, and PEF. Therefore only the effort-independent test should be used to study correctly the bronchial tone.
mesh_terms: D000293:Adolescent; D000328:Adult; D000403:Airway Resistance; D001249:Asthma / Q000503:physiopathology*; D002940:Circadian Rhythm; D005260:Female; D005652:Functional Residual Capacity; D006801:Humans; D008297:Male; D010366:Peak Expiratory Flow Rate; D012115:Residual Volume; D012119:Respiration; D014797:Vital Capacity
vernacular_title: Ritmo circadiano dei parametri ventilatori nell'asma primitiva in remissione clinica.