[Factors responsible for increasing the cytogenetic effectiveness of cyclophosphamide administered to irradiated animals. Mutagenic effect of cyclophosphamide on irradiated and intact cells in culture].
The frequency of cyclophosphamide-induced chromosome aberrations in preirradiated cultures of L-cells and embryonal rat fibroblasts has been estimated. The mutagen was subjected to nonenzymatic activation in solution at 37 degrees C. In contrast to the results previously obtained on animals we failed to observe any influence of preirradiation on the cytogenetic effect of cyclophosphamide.
D000818:Animals; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000494:pharmacology*; D007739:L Cells / Q000187:drug effects / Q000528:radiation effects*; D051379:Mice; D009153:Mutagens; D051381:Rats; D013997:Time Factors
D009153:Mutagens; D003520:Cyclophosphamide
Izuchenie prichin, obuslovlivaiushchikh usilenie tsitogeneticheskoĭ éffektivnosti tsiklofosfana pri vvedenii ego obluchennym zhivotnym. Mutagenno deĭstvie tsiklofosfana na obluchennye i intaktnye kletki v kul'ture.