Anti-IgA in selective IgA deficiency. In vitro effects and Ig subclass pattern of human anti-IgA.
Anti-IgA antibodies were found in 14 of 33 (42%) IgA-deficient donors. In healthy IgA-deficient blood donors anti-IgA appeared associated with the presence of HLA DR3. The antibodies were mainly of the IgG1 and, in high-titred sera, IgG4 subclasses. Sera containing high-titred anti-IgA selectively impaired IgA synthesis in vitro as induced by direct and indirect polyclonal B-cell activators. These antibodies may play a role in the pathogenesis and/or the maintenance of IgA deficiency.
D000888:Antibodies, Anti-Idiotypic / Q000145:classification / Q000235:genetics / Q000276:immunology*; D000921:Antibody-Producing Cells / Q000276:immunology; D002478:Cells, Cultured; D004406:Dysgammaglobulinemia / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D006680:HLA Antigens; D015234:HLA-A Antigens; D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II; D006801:Humans; D017098:IgA Deficiency; D007070:Immunoglobulin A / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D006680:HLA Antigens; D015234:HLA-A Antigens; C037164:HLA-A28 antigen; D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; D000949:Histocompatibility Antigens Class II; D007070:Immunoglobulin A