[Thymus target cells subject to the regulatory effect of macrophages during the formation of graft-versus-host reaction effectors].
The data are provided on the interaction of macrophages with different thymocyte subpopulations during the formation of T cells entering the graft-versus-host reaction (GVHR). The intensity of the local GVHR was evaluated from the index of lymph node enlargement. The cortisone-sensitive, relatively radioresistant cells lying in the thymus cortex and migrating to the spleen have been demonstrated to serve as targets for the regulatory effect of macrophages. On the basis of a complex of the characteristics these cells have been identified as T1 cells.
D000818:Animals; D000937:Antigen-Antibody Reactions; D003601:Cytotoxicity Tests, Immunologic; D006087:Graft vs Host Reaction; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000276:immunology*
Kletki-misheni timusa, nakhodiashchiesia pod reguliatornym vliianiem makrofagov pri obrazovanii éffektorov reaktsii transplantat protiv khoziaina.