CNS lesions in neonatal isoimmune thrombocytopenia.
We treated two siblings with classic neonatal isoimmune thrombocytopenia and porencephalic cysts in whom the CNS lesions occurred in a vascular distribution, for which there is no clear explanation. Whether the CNS vasculature is injured by the immune process at certain susceptible sites in larger vessels or whether there is a thrombotic process occurring at sites of vascular injury is speculative. This observation suggests that vascular factors are involved in the development of CNS lesions in this condition.
D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D002543:Cerebral Hemorrhage / Q000209:etiology; D003560:Cysts / Q000000981:diagnostic imaging / Q000209:etiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007519:Isoantigens / Q000276:immunology*; D013921:Thrombocytopenia / Q000150:complications / Q000276:immunology*; D014057:Tomography, X-Ray Computed
D007519:Isoantigens