[Myocardial 201-thallium uptake after hydralazine in coronary disease].
Following injection of hydralazine, a benign coronary-artery-dilating drug, myocardial blood flow increased by 25%. Myocardial 201-thallium uptake at rest and after intravenous injection of 12 mg hydralazine was quantitatively investigated in 28 patients. In patients with essential hypertension or coronary artery stenoses of up to 90%, myocardial 201-thallium uptake increased by 19%-30% in nonischemic areas. In 9 of 14 patients with regional imaging defects, thallium uptake also increased in these ischemic areas; 4 of these patients had asynergies in the area of imaging defects. In 3 patients with a complete obstruction of a major branch of a coronary artery perfusion defects developed following hydralazine application.


CONCLUSIONS
An increased 201-thallium uptake in an ischemic area indicates reperfusion; this could be helpful for deciding whether coronary surgery should be performed or not.
D003326:Coronary Circulation / Q000187:drug effects; D003327:Coronary Disease / Q000378:metabolism*; D006801:Humans; D006830:Hydralazine / Q000494:pharmacology*; D006973:Hypertension / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011868:Radioisotopes; D013793:Thallium / Q000378:metabolism*
D011868:Radioisotopes; D006830:Hydralazine; D013793:Thallium
Myokardiale 201-Thallium-Speicherung nach Hydralazin bei koronarer Herzkrankheit.