title: Bombesin-like immunoreactivity in the pituitary gland.
abstract: Bombesin has been shown to stimulate release of anterior pituitary hormones both in vivo and in vitro. The aim of this study was to determine whether bombesin-like immunoreactivity could be detected in the human pituitary. Significant concentrations were found in the human anterior gland (4.6 +/- 1.5 pmoles/g), posterior gland (1.5 +/- 0.4 pmoles/g) and stalk (8.1 +/- 0.8 pmoles/g). Significant amounts were also observed in the guinea-pig pituitary. Gel permeation chromatography revealed the presence of 2 major molecular forms of bombesin-like immunoreactivity, one co-eluting with porcine gastrin-releasing peptide and the other with amphibian bombesin.
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D001839:Bombesin / Q000032:analysis*; D005260:Female; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000032:analysis*; D010902:Pituitary Gland / Q000032:analysis*; D014018:Tissue Distribution
chemical_list: D010455:Peptides; D001839:Bombesin