A new disease: a nasal form of pigeon breeder's disease.
In 47 allergic rhinitis patients regularly exposed to pigeons, nasal provocation tests with pigeon dropping extracts, in combination with other parameters, were performed. Twenty-five of the 47 patients developed a late nasal response (LNR) to pigeon droppings (53%), six of them an isolated response and 19 a dual response (immediate + late). The precipitating antibodies to pigeon droppings were positive in 20 (80%) and to pigeon serum in nine LNR patients (36%). Late skin responses to pigeon droppings occurred in 15 (60%) and to pigeon serum in seven LNR patients (28%). In 13 patients (52%) general malaise, in seven (28%) increased blood eosinophilia, in nine (36%) increased body temperature and in 11 (44%) haemorrhages in the nasal mucosa were observed during the LNR. The results of this study provide evidence for the existence of a new disease, a nasal form of pigeon breeder's disease.
D000293:Adolescent; D000328:Adult; D000485:Allergens / Q000008:administration & dosage; D000542:Alveolitis, Extrinsic Allergic / Q000150:complications*; D000818:Animals; D001716:Bird Fancier's Lung / Q000150:complications* / Q000175:diagnosis; D002648:Child; D010856:Columbidae; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis; D006969:Hypersensitivity, Immediate / Q000175:diagnosis; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000378:metabolism / Q000473:pathology; D009299:Nasal Provocation Tests; D011234:Precipitins / Q000032:analysis; D012221:Rhinitis, Allergic, Perennial / Q000175:diagnosis / Q000209:etiology*; D013997:Time Factors
D000485:Allergens; D011234:Precipitins; D007073:Immunoglobulin E