Effect of 12-O-tetradecanoylphorbol-13-acetate on polyamine metabolism in mice sensitive and resistant to lung-adenoma.
Ornithine decarboxylase activity and polyamine concentrations were determined in the lungs of mice from 0 to 20 h after treatment with 12-O-tetradecanoylphorbol-13-acetate (17.7 nmol in 0.2 ml acetone/mouse). In CFLP mice, which responded to carcinogen with development of lung-adenomas, a single topical application of TPA to hairless mouse skin increased ornithine decarboxylase activity in the lung. In contrast, in C3H/He-mg mouse strain, which were resistant to lung-adenoma production, TPA application did not increase ODC activity of the lungs.
D000236:Adenoma / Q000139:chemically induced* / Q000201:enzymology / Q000235:genetics; D000818:Animals; D008168:Lung / Q000201:enzymology; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000201:enzymology / Q000235:genetics; D051379:Mice; D008809:Mice, Inbred C3H; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D010704:Phorbols; D011073:Polyamines / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate
D010704:Phorbols; D011073:Polyamines; D009955:Ornithine Decarboxylase; D013755:Tetradecanoylphorbol Acetate