Intermittent chemoprophylaxis for Pneumocystis carinii pneumonia.
An intermittent regimen of trimethoprim-sulfamethoxazole was tested in the corticosteroid-treated rat model to learn whether or not administration for 3 consecutive days a week would provide prophylaxis equal to continuous daily doses. Although all of the untreated control animals acquired Pneumocystis carinii pneumonia, none of the animals given either continuous or intermittent trimethoprim-sulfamethoxazole became infected.
D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D004338:Drug Combinations / Q000008:administration & dosage; D008297:Male; D011020:Pneumonia, Pneumocystis / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D013420:Sulfamethoxazole / Q000008:administration & dosage*; D014295:Trimethoprim / Q000008:administration & dosage*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D000890:Anti-Infective Agents; D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole