title: Perineal sinus after removal of the rectum. Occlusion with fibrin adhesive.
abstract: Ten patients with a discharging perineal sinus that developed after proctectomy were treated with a new fibrin adhesive system in order to close the sinus. Four of the patients also had a fistula that extended from the sinus to the vagina. Treatment was unsuccessful in two patients: one had retained foreign bodies in the sinus and the other had a rather large spheric cavity. In eight patients the sinus healed after application of fibrin adhesive, even when a fistula to the vagina was present. The method seems to be effective for closing a long, narrow perineal sinus.
mesh_terms: D000328:Adult; D000368:Aged; D003093:Colitis, Ulcerative / Q000601:surgery; D003424:Crohn Disease / Q000601:surgery; D004338:Drug Combinations; D005176:Factor XIII; D005260:Female; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen; D005402:Fistula / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D010502:Perineum / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery; D011183:Postoperative Complications; D011859:Radiography; D012004:Rectal Neoplasms / Q000601:surgery; D012007:Rectum / Q000601:surgery*; D013917:Thrombin; D014014:Tissue Adhesives; D014624:Vaginal Fistula / Q000628:therapy; D014945:Wound Healing
chemical_list: D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D005340:Fibrinogen; D005176:Factor XIII; D013917:Thrombin