Uptake of elemental mercury by brain in relation to concentration of glutathione and activity of glutathione peroxidase.
Uptake of mercury by brain after i.v. injection of elemental mercury was investigated in the rat, after depletion of glutathione or inhibition of glutathione peroxidase in brain tissue. When glutathione in brain was depleted 76% by an intraventricular injection of diethylmaleate, a 13% increase in mercury uptake by brain was observed. After an intraventricular injection of iodoacetate, activity of glutathione peroxidase in brain was inhibited 19% and the content of reduced glutathione was decreased 20%. In these animals mercury uptake by brain increased 66% relative to controls.
D000818:Animals; D001692:Biological Transport; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism*; D007461:Iodoacetates / Q000494:pharmacology; D019807:Iodoacetic Acid; D007700:Kinetics; D008297:Male; D008298:Maleates / Q000494:pharmacology; D008628:Mercury / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D007461:Iodoacetates; D008298:Maleates; D005979:Glutathione Peroxidase; D008628:Mercury; C014476:diethyl maleate; D005978:Glutathione; D019807:Iodoacetic Acid