[Effect of parathyroidin on the course of acute myocardial ischemia in experiments on rats].
Experiments were made on 187 white rats weighing 180-200 g. Acute myocardial ischemia was simulated in 137 animals. Fifty sham-operated rats served as control. Experimental acute myocardial ischemia was accompanied by an increase in blood creatine phosphokinase and lactate dehydrogenase activity as well as by an elevation of serum lactate level and fall of blood plasma calcium concentration, suppression of diuresis and excretion of calcium with urine. Intraperitoneal injections of parathyroidine to rats with acute myocardial ischemia led to rapid normalization of the homeostatic parameters. Lethality of experimental animals decreased 1.8-fold.
D000208:Acute Disease; D000818:Animals; D002118:Calcium / Q000097:blood / Q000652:urine; D003327:Coronary Disease / Q000188:drug therapy* / Q000378:metabolism; D003402:Creatine Kinase / Q000097:blood; D004231:Diuresis / Q000187:drug effects; D005260:Female; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007773:Lactates / Q000097:blood; D008297:Male; D010281:Parathyroid Hormone / Q000627:therapeutic use*; D051381:Rats
D007773:Lactates; D010281:Parathyroid Hormone; C039549:parathyroidin; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D002118:Calcium
Vliianie paratireoidina na techenie ostroĭ ishemii miokarda v éksperimente na krysakh.