Gastrin-releasing peptide-related peptides in a human malignant lung carcinoid tumor.
Recent immunohistochemical findings have indicated the presence of gastrin-releasing peptide in normal and pathological human lungs. Gastrin-releasing peptide is a 27-amino acid peptide isolated from porcine gut which bears considerable carboxyterminal homology with bombesin. We have characterized the gastrin-releasing peptide-like peptides present in a human malignant lung carcinoid tumor by gel chromatography and reverse-phase high-performance liquid chromatography. Our results show that this tumor did not contain bombesin; however, this tumor expressed a gastrin-releasing peptide-like compound, several amino-terminal fragments, and a carboxy-terminal fragment of gastrin-releasing peptide.
D000595:Amino Acid Sequence; D002276:Carcinoid Tumor / Q000648:ultrastructure*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D019886:Gastrin-Releasing Peptide; D005768:Gastrointestinal Hormones / Q000032:analysis*; D006801:Humans; D008175:Lung Neoplasms / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008875:Middle Aged; D010455:Peptides / Q000032:analysis*
D005768:Gastrointestinal Hormones; D010455:Peptides; D019886:Gastrin-Releasing Peptide