Direct influence of dexamethasone in vivo on rat testicular lipogenic enzymes involved in pyruvate-malate pathway.
The changes in specific activities of NADP-isocitrate dehydrogenase, ATP-citrate lyase, Malate dehydrogenase and malic enzyme were studied in adrenalectomised and dexamethasone injected pubertal rats. One month after adrenalectomy the specific activity of NADP-isocitrate dehydrogenase increased but the specific activities of the other three enzymes decreased. An opposite effect was seen after dexamethasone administration to intact animals. The changes observed in the specific activities of enzymes of adrenalectomised and dexamethasone treated animals reverted back to normal after dexamethasone replacement and withdrawal, respectively.
D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism; D000315:Adrenalectomy; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D007521:Isocitrate Dehydrogenase / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D008293:Malates / Q000378:metabolism*; D008297:Male; D011773:Pyruvates / Q000378:metabolism*; D019289:Pyruvic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000201:enzymology*
D008293:Malates; D011773:Pyruvates; D003907:Dexamethasone; C030298:malic acid; D019289:Pyruvic Acid; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; D001275:ATP Citrate (pro-S)-Lyase