Effect of prolonged cold storage on the mechanical activity of rabbit atria.
Even after 21 days of cold storage at 2 degrees C, rabbit atria still showed a detectable response only to isoproterenol while other cardiostimulants (norepinephrine, ouabain, anthopleurin-A and nicotine) failed to activate tissues stored up to 14 days. The specific fluorescence of catecholamines disappeared from the tissue after 5 days of cold storage. The maximum decrease in oxygen consumption and tissue catecholamine content was observed after 14 days and a concomitant decrease in tissue ATP content, Na+-K+, Ca2+ and Mg2+-ATPases was nearly maximal after 7 days of cold storage. The cold storage had no apparent effect on the ultrastructures of myocardial cells except a disappearance in glycogen granules.
D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D003080:Cold Temperature; D004305:Dose-Response Relationship, Drug; D005260:Female; D006321:Heart / Q000502:physiology; D006651:Histocytochemistry; D036341:Intercellular Signaling Peptides and Proteins; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000032:analysis; D009638:Norepinephrine / Q000032:analysis; D009926:Organ Preservation; D010042:Ouabain / Q000494:pharmacology; D010101:Oxygen Consumption; D010455:Peptides / Q000494:pharmacology; D011817:Rabbits
D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D010042:Ouabain; C012746:anthopleurin-A; D000255:Adenosine Triphosphate; D009638:Norepinephrine