Immediate and delayed effects of vincristine administered during early postimplantation stages of murine embryogenesis.
Vincristine was given to pregnant mice on day 7 1/2 of pregnancy and the teratogenic effects of this treatment were assessed 2 and 3 days thereafter. Most of the embryos in litters removed on day 9 1/2 of pregnancy (2 days after treatment) were morphologically normal, whereas on day 10 1/2 most embryos were either developmentally retarded by the treatment or malformed. The morphologically "normal" embryos removed on day 9 1/2 of pregnancy were cultured in vitro for 24 h. During this procedure more than 50% of them showed growth retardation or abnormal development. These data indicate that exposure of early postimplantation embryos to vincristine has an immediate teratogenic and embryocidal action, and also a delayed effect which becomes apparent only several days after exposure and following an ostensibly "normal" period of embryonic development.
D000818:Animals; D047108:Embryonic Development / Q000187:drug effects*; D005260:Female; D005865:Gestational Age; D051379:Mice; D011247:Pregnancy; D013723:Teratogens; D013997:Time Factors; D014750:Vincristine / Q000494:pharmacology*
D013723:Teratogens; D014750:Vincristine