Leukotriene D4 induces bronchoconstriction in man.
The effect of leukotriene D4 (LTD4) on lung function was investigated in a controlled study on four normal subjects. A pronounced decrease in airflow was found after inhalation of less than 0.5 nmol, and was most pronounced in the variables generally accepted as indicators of the function of the small airways. No subjective symptoms were experienced.
D001249:Asthma / Q000503:physiopathology; D001980:Bronchi / Q000187:drug effects*; D006801:Humans; D012123:Pulmonary Ventilation / Q000187:drug effects*; D013189:SRS-A / Q000276:immunology* / Q000494:pharmacology
D013189:SRS-A