title: The central-peripheral transition zone of cervical spinal nerve roots in Jimpy mutant and normal mice. Light- and electron-microscopic study.
abstract: Comparative morphological and ultrastructural investigations on the cervical dorsal and ventral central-peripheral transition zones (CPTZs) of Jimpys and control mice have been performed at early and advanced myelination stages. After postnatal development a characteristic cone-shaped glial outgrowth extends into the proximal part of the dorsal roots, while the ventral roots exhibit short Schwann cell and peripheral nervous tissue invaginations into the spinal cord at the ventral root-spinal cord junction in both animal groups. In Jimpys, although there is marked central myelin deficiency and absence of oligodendroglial development on the CNS side, the normal general aspect of the CPTZs is maintained. Previously postulated astrocytic and neuroaxonal abnormalities in the mutants do not alter the central-peripheral borderline, and Schwann cell migration from the spinal nerve roots into the cord does not occur.
mesh_terms: D000818:Animals; D051379:Mice / Q000033:anatomy & histology*; D008816:Mice, Jimpy; D008818:Mice, Neurologic Mutants; D008854:Microscopy, Electron; D009457:Neuroglia / Q000648:ultrastructure; D009836:Oligodendroglia / Q000648:ultrastructure; D012583:Schwann Cells / Q000648:ultrastructure; D013126:Spinal Nerve Roots / Q000648:ultrastructure*