Prevention of structural arteriolar changes in DOCA hypertension with hydrallazine.
Structural changes in resistance vessels were studied by (a) hindquarter perfusion; and (b) planimetry of cross-sections of renal arterioles in uninephrectomized rats treated for 10 weeks with saline and either DOCA (deoxycorticosterone acetate), DOCA plus hydrallazine, vehicle plus hydrallazine or vehicle only. DOCA-treated rats developed hypertension and structural change. Addition of hydrallazine prevented both hypertension and the development of structural change. Structural arteriolar change in DOCA/salt hypertension is related to the high blood pressure or a closely associated factor rather than some other effect of DOCA.
D000818:Animals; D001160:Arterioles / Q000187:drug effects; D003900:Desoxycorticosterone / Q000633:toxicity*; D006830:Hydralazine / Q000627:therapeutic use*; D006973:Hypertension / Q000139:chemically induced / Q000517:prevention & control*; D007668:Kidney / Q000098:blood supply*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D006830:Hydralazine; D003900:Desoxycorticosterone