Immunomodulating properties and tissue distribution of aromatic retinoids in the immunologically responsive albino rabbit eye.
The effects of retinoid Ro 10-9359 no normal albino rabbit eyes and antigen-induced intra-ocular inflammations were investigated. The distribution pattern of intravenously applied 3H--Ro 10-9359 correlated well with the sites of pharmacological action. Whereas immunologically naive rabbits showed a uveal uptake of 0.164 ng/g wet wt. tissue when 100 micrograms of Ro 10-9359 was administered intravenously, accumulation may amount up to 17.46 ng/g in secondary ocular immune responses. Ro 10-9359 accumulated markedly during secondary stimulation in the uvea, preauricular lymph nodes and the spleen. The chemotactic peptide NForm-Leu-Leu-Phe used to incite a hypopyon attracted Ro 10-9359 into the anterior chamber in vivo. This study indicates that the aromatic retinoid Ro 10-9359 is able to alter certain immune responses and may be involved in intercellular communication during secondary immune responses in the albino rabbit eye.
D000818:Animals; D005050:Etretinate / Q000032:analysis / Q000494:pharmacology* / Q000627:therapeutic use; D005123:Eye / Q000032:analysis / Q000187:drug effects* / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D007249:Inflammation / Q000139:chemically induced; D010455:Peptides / Q000009:adverse effects; D011817:Rabbits; D014605:Uveitis / Q000188:drug therapy*
D010455:Peptides; D005050:Etretinate