[Study of allergy to general anesthetics and muscle relaxants using the lymphoblast transformation test].
This study aims to test the lymphocyte response in normal subjects and patients who presented an anaphylactoid shock to various anaesthetic and muscle relaxant drugs, by using the lymphoblast transformation test (LTT). The results show that, although the LTT is a specific test, which can be carried out in vitro, it is badly adapted to the biological diagnosis of anaphylactic drug accidents on the whole, because of a possible non specific lymphoblastic transformation in controls or, on the contrary, of false negative results in anaphylaxis. As a consequence of this, and some comparative studies, the diagnosis of drug induced anaphylaxis must rely on skin tests, human basophil degranulation test (HBDT) and the Prausnitz-Küstner test.
D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced / Q000276:immunology*; D000768:Anesthesia, General / Q000009:adverse effects; D000777:Anesthetics / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology / Q000276:immunology*; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D009466:Neuromuscular Blocking Agents / Q000009:adverse effects*; D013390:Succinylcholine / Q000009:adverse effects*
D000777:Anesthetics; D009466:Neuromuscular Blocking Agents; D013390:Succinylcholine
Etude de l'allergie aux anesthésiques généraux et aux myorelaxants par le test de transformation lymphoblastique.