Comparison of single dose with a 5-day course of co-trimoxazole for asymptomatic (covert) bacteriuria of pregnancy.
Forty-four pregnant women with covert (asymptomatic) bacteriuria proven by suprapubic bladder aspiration were randomly allocated to treatment with either a single 1.92g dose or a standard 5-day course of co-trimoxazole. Twenty-one of 24 women were cured with a single dose. Seven of these 21 women were reinfected later in the pregnancy. All 20 women treated with a 5-day course of co-trimoxazole were cured, and 2 became reinfected later in the pregnancy. There were no side-effects of treatment, and no detrimental effects on the outcome of pregnancy. Single dose therapy should be considered as the treatment of choice for covert bacteriuria in pregnancy.
D000328:Adult; D000892:Anti-Infective Agents, Urinary / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D006801:Humans; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy*; D012008:Recurrence; D013420:Sulfamethoxazole / Q000627:therapeutic use*; D014295:Trimethoprim / Q000627:therapeutic use*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014552:Urinary Tract Infections / Q000188:drug therapy*
D000892:Anti-Infective Agents, Urinary; D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole