title: The comparative roles of dopaminergic and serotonergic mechanisms in mediating quipazine induced increases in locomotor activity.
abstract: The effect of dopaminergic and serotonergic agonists and antagonists on quipazine induced locomotor activity was investigated in rats. Though quipazine is generally considered to be a relatively pure serotonergic agonist, its effects on locomotor activity were inhibited by small doses of a centrally acting DA receptor blocking agent (haloperidol), while three different serotonergic (5-HT) antagonists were without effect on this behavior. Moreover, quipazine induced locomotor activity was markedly inhibited by the 5-HT substrate 5-hydroxytryptophan. The data suggest that quipazine induced locomotor activity primarily involves dopaminergic mechanisms, with 5-HT playing either no role in stimulating this behavior, or a subsidiary one, requiring intact central dopaminergic receptors for its expression.
mesh_terms: D000818:Animals; D004298:Dopamine / Q000502:physiology*; D004347:Drug Interactions; D006220:Haloperidol / Q000008:administration & dosage; D008124:Locomotion / Q000187:drug effects; D008297:Male; D008719:Methiothepin / Q000008:administration & dosage; D008784:Methysergide / Q000008:administration & dosage; D009043:Motor Activity / Q000187:drug effects*; D011804:Quinolines / Q000494:pharmacology*; D011814:Quipazine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*
chemical_list: D011804:Quinolines; D012701:Serotonin; D011814:Quipazine; D008719:Methiothepin; D006220:Haloperidol; D004298:Dopamine; D008784:Methysergide