title: Effect of triethyl lead on the placental uptake and transfer of the non-metabolisable alpha-aminoisobutyric acid in guinea pigs.
abstract: In order to study the effect of organolead on the placental transfer of amino acids, triethyl lead chloride was administered by i.p. injections to pregnant guinea-pigs. The following day, the fetal part of the placenta was perfused in situ during i.v. infusion of alpha-aminoisobutyric acid (AIB) to the dam. It was found that triethyl lead treatment (2.5 mg/kg body wt) decreased the AIB-concentration in perfusion media compared with that of the control group. Treatment with 1 mg/kg body wt has no effect. It was also shown that the placental uptake of AIB in animals receiving 2.5 mg/kg body wt is significantly reduced compared with that of the control group. No such effect was obtained in animals receiving 1 mg/kg body wt. It is suggested that triethyl lead may inhibit placental Na+-K+-adenosinetriphosphatase, an enzyme involved with placental amino acid transport. Another possible explanation is a reduction in maternal placental blood flow.
mesh_terms: D000621:Aminoisobutyric Acids / Q000378:metabolism*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D007854:Lead / Q000633:toxicity*; D008297:Male; D009942:Organometallic Compounds / Q000633:toxicity*; D010920:Placenta / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy
chemical_list: D000621:Aminoisobutyric Acids; D009942:Organometallic Compounds; C100049:2-aminoisobutyric acid; D007854:Lead; C010360:triethyllead