[Detection of virus-specific protein synthesis in animal organs].
Registration of intracellular protein syntheses in vivo was shown to be possible by inoculation of labeled amino acids directly into animal organs. In the lungs of intranasally infected mice there occurs inhibition of cellular protein syntheses against the background of which synthesis of virion proteins is recorded. In the brains of intracerebrally inoculated animals intracellular protein synthesis is enhanced. The recommended approach opens ways for investigations of the molecular mechanisms of the pathogenesis of viral infections as well as mechanisms of virulence.
D000818:Animals; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry; D002642:Chick Embryo; D004591:Electrophoresis, Polyacrylamide Gel; D008168:Lung / Q000032:analysis / Q000378:metabolism; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000378:metabolism; D011506:Proteins / Q000032:analysis; D013045:Species Specificity; D013997:Time Factors; D014764:Viral Proteins / Q000032:analysis* / Q000096:biosynthesis; D014776:Virus Cultivation
D011506:Proteins; D014764:Viral Proteins
Vyiavlenie virusspetsificheskikh belkovykh sintezov v organakh zhivotnykh.