Evidence for an inhibitory role of beta-endorphin and other opioids on human total T rosette formation.
Beta-endorphin, met-enkephalin, leu-enkephalin and morphine significantly inhibit rosette formation between human T lymphocytes and sheep red blood cells. This effect is completely reversed by naloxone, a specific antagonist, while naloxone by itself does not influence rosette formation. A further link between the immune system and the neuroendocrine system is suggested.
D004723:Endorphins / Q000494:pharmacology*; D006801:Humans; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects*
D004723:Endorphins; D009270:Naloxone; D009020:Morphine