Glycophorin A inhibits lysis by the complement attack phase.
A glycoprotein from human erythrocyte membranes has been found to inhibit lysis of target cells by the attack-phase components C5-C9 from human complement. The inhibiting molecule was purified and identified as glycophorin A. Thus, glycophorin A may have a regulatory function in the lytic complement attack on isologous cells.
D000818:Animals; D002645:Chickens; D003169:Complement Inactivator Proteins / Q000502:physiology*; D015938:Complement Membrane Attack Complex; D003165:Complement System Proteins / Q000378:metabolism*; D006021:Glycophorins / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology*; D006168:Guinea Pigs; D006461:Hemolysis; D006801:Humans; D007108:Immune Tolerance; D008951:MNSs Blood-Group System; D012795:Sialoglycoproteins / Q000502:physiology*
D003169:Complement Inactivator Proteins; D015938:Complement Membrane Attack Complex; D006021:Glycophorins; D008951:MNSs Blood-Group System; D012795:Sialoglycoproteins; D003165:Complement System Proteins