title: [Hyperglycemic and therapeutic action of nontranquilizing doses of xylazine in healthy sheep and cows and in cows with subclinical ketosis].
abstract: Experiments with 19 sheep and 26 cows revealed that subcutaneous and muscular injection of xylasine (Rompun - Bayer at 0.04 to 0.08 mg/kg body mass) led to a dependable increase in the level of blood sugar by 50-220 per cent for a period of 1 to 3 hrs. At the 6th to the 24th hour the amount of blood sugar came back to normal. In cows with subclinical ketosis (ketonuria ++ to +++ after Lastradet's test) and hypoglycaemia (blood sugar 29.7 +/- 4.6 mg%) the injection of xylasine (0.05-0.08 mg/kg body mass) increased the level of blood sugar by 169 to 185 per cent, which remained at a comparatively high level up to the 24th hour. Ketonuria dropped, however, full dusapperance of ketone bodies in the urine was observed in 7 per cent of the treated animals only. It is believed that although there was a pronounced hyperglycaemic effect of the preparation it cannot be applied alone for the treatment of ketosis-affected cows. It is important as an additional means, particularly with animals affected with the nervous form of the disease.
mesh_terms: D000138:Acidosis / Q000662:veterinary*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation / Q000662:veterinary; D005260:Female; D006943:Hyperglycemia / Q000139:chemically induced / Q000662:veterinary*; D007662:Ketosis / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D007774:Lactation; D011247:Pregnancy; D012756:Sheep; D013843:Thiazines / Q000008:administration & dosage*; D013997:Time Factors; D014991:Xylazine / Q000008:administration & dosage*
chemical_list: D001786:Blood Glucose; D013843:Thiazines; D014991:Xylazine
vernacular_title: Prouchvane khiperglikemichnoto i lechebnoto deĭstvie na netrankvilizirashte dozi ksilazin pri zdravi ovtse i kravi i pri kravi sŭs subklinichna ketoza.