[Epidural buprenorphine for postoperative analgesia after hip operations].
Two groups of 20 patients each were given immediately after hip-operation an epidural injection of 0,15 or 0,3 mg buprenorphine. Effects and side effects are compared with those observed in two groups of patients having the same type of operation, and given either 4 mg of morphine or saline (placebo) by epidural injection. Buprenorphine in both doses produced a shorter duration of analgesia than 4 mg of morphine. In no case did respiratory depression occur. Urinary retention after buprenorphine was barely more frequent than in the placebo group. Nausea and vomiting occurred in 35-45% of patients. We do not see an advantage in replacing morphine by buprenorphine for epidural opiate-analgesia, because the same high rate of nausea/vomiting is associated with a significantly shorter duration of analgesia after buprenorphine. We are convinced that epidural opiate-analgesia is most valuable for postoperative pain relief but should be reserved for selected cases.
D000368:Aged; D002047:Buprenorphine / Q000008:administration & dosage*; D004824:Epidural Space; D006622:Hip Prosthesis; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D009019:Morphinans / Q000008:administration & dosage*; D009020:Morphine / Q000627:therapeutic use; D010149:Postoperative Pain / Q000150:complications / Q000188:drug therapy*
D009019:Morphinans; D002047:Buprenorphine; D009020:Morphine
Epidurales Buprenorphin für postoperative Analgesie nach Hüftoperationen.