Preliminary report on the therapeutic effect of khellin in psoriasis.
A double-blind study has been performed to search for the possible effect of khellin in psoriasis. 10 patients were treated orally with khellin and subsequently exposed to sunlight for 4 months; a total of 8 cases responded positively with variable degrees of clearance. None of 10 controls had any response. A relapse-free duration of 3 years was recorded for 6 out of the 8 responders. This study would introduce the nonpsoralen compound khellin as a possible agent for the therapy of psoriasis.
D000293:Adolescent; D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006370:Heliotherapy; D006801:Humans; D007666:Khellin / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy*
D007666:Khellin