True histiocytic lymphoma: an immunohistochemical and ultrastructural study of two cases.
Immunologic studies demonstrate that non-Hodgkin's lymphomas are derived predominantly from B- or T-lymphoid cells, while node-based tumors of true histiocytic derivation are rare, with few documented cases. This report describes the clinical, histologic, immunohistochemical, and ultrastructural features of two cases of node-based true histiocytic lymphoma. Distinctive ultrastructural features included numerous cytoplasmic lysosomes, surface microvillous processes, and occasional cell junctions, and the cells stained strongly for alpha-napthyl acetate esterase and alpha one-antitrypsin. Since there are few specific histologic features, special technics may be essential in confirming the diagnosis of true histiocytic lymphoma, and determining appropriate therapy.
D000954:Antigens, Surface / Q000276:immunology; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000648:ultrastructure; D006644:Histiocytes; D006651:Histocytochemistry; D006801:Humans; D008223:Lymphoma / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009113:Muramidase / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
D000954:Antigens, Surface; D000515:alpha 1-Antitrypsin; D009113:Muramidase