[Effect of motor function disorder on the properties of the muscle fiber membrane].
Experiments on frogs with the use of the microelectrode techniques were made to study the effect of tenotomy and immobilization of a limb with a metal cast in the extension position on the properties of the membrane of muscle fibers. Two weeks after tenotomy there were no changes in the magnitude of the membrane rest potential, input resistance and time constant of the membrane of muscle fibers or in the pattern of its sensitivity to acetylcholine. Two and three weeks after the limb immobilization no changes in the membrane rest potential and passive electrical properties of the muscle membrane were recorded either. However, if the time elapsed after immobilization was 2 and 3 weeks, the zone of the sensitivity of muscle fibers to acetylcholine was slightly greater than in the control. It is suggested that the motor activity in the frog per se is not the determinant of the muscle fiber differentiation preset by the nervous system.
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D007103:Immobilization; D008564:Membrane Potentials; D009068:Movement; D009121:Muscle Denervation; D009132:Muscles / Q000503:physiopathology*; D011896:Rana temporaria
D000109:Acetylcholine
Vliianie narusheniia dvigatel'noĭ funktsii na svoĭstva membrany skeletnykh myshechnykh volokon.