title: Cardiac effects of clomipramine treatment. ECG and left ventricular systolic time intervals.
abstract: ECGs and left ventricular systolic time intervals were studied in 26 patients suffering from major depressive disorder treated with clomipramine. ECGs did not show, with one exception, drug-induced changes. The ratio of pre-ejection period to left ventricular ejection time, both corrected for heart rate (PEPc/LVETc), presented no significant changes, as compared with initial findings, in the group of patients considered as a whole. 27% of patients, however, showed individual percent changes greater than 8%, both increases and decreases having been observed. Cardiac findings were in no way related to clomipramine plasma levels.
mesh_terms: D000368:Aged; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D001794:Blood Pressure; D009202:Cardiomyopathies / Q000139:chemically induced*; D002997:Clomipramine / Q000009:adverse effects* / Q000097:blood; D003866:Depressive Disorder / Q000188:drug therapy; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction
chemical_list: D002997:Clomipramine