Delayed dimethylformamide biotransformation after high exposures in rats.
Rats were exposed to two dimethylformamide (DMF) air concentrations (2250 and 565 ppm for 4 h). Concentrations of DMF and the biotransformation product monomethylformamide (MMF) were measured in blood and some tissues at different times after the end of exposure. MMF concentrations 0 and 3 h after the end of the high exposure were generally lower than MMF concentrations at the same time after the low exposure. The results suggest that DMF biotransformation to MMF is delayed after the high exposure. As the hepatotoxic effect of DMF has been correlated with MMF, this could contribute to the previously observed slower appearance of hepatotoxicity after a high compared to a low DMF dose.
D000311:Adrenal Glands / Q000187:drug effects / Q000473:pathology; D000818:Animals; D001711:Biotransformation; D001921:Brain / Q000187:drug effects / Q000473:pathology; D004126:Dimethylformamide / Q000378:metabolism* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004126:Dimethylformamide