Influence of Y and X chromosomes on B cell responses in autoimmune prone mice.
BXSB mice, unlike other autoimmune strains, carry a Y chromosome-linked gene for accelerated autoimmunity, reflected by early onset disease in male but not female animals. To investigate whether the Y chromosome factor acts through other autosomal genes or is in itself sufficient for early disease, partially inbred congenic NZB.BXSB and NZW.BXSB mice were developed and studied for levels of Ig-secreting cells (IgFC) as a measure of their autoimmune state. In such mice, the BXSB contributed only the male chromosome and 3% of the autosomal genes. The results indicate that for full expression of autoimmunity, both the Y chromosome and one or more BXSB autosomal genes are required. In addition, the presence of the CBA/N xid gene results in a total reversal of any Y-linked effects.
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology / Q000235:genetics* / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D003433:Crosses, Genetic; D005260:Female; D008040:Genetic Linkage; D007074:Immunoglobulin G / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D012729:Sex Chromosome Aberrations / Q000276:immunology; D014960:X Chromosome / Q000502:physiology*; D014998:Y Chromosome / Q000502:physiology*
D007074:Immunoglobulin G