title: Statistical methods for in vitro cell survival assays.
abstract: Statistical methods are presented for estimating and comparing survival curves obtained from experiments in which cells are exposed in vitro to increasing doses of a DNA-damaging agent. These methods, which are applicable in a variety of cell survival assays, are illustrated in the evaluation of two sets of experiments in which the colony-forming ability of fibroblast cell lines from 9 muscular dystrophy patients and 17 normal individuals were studied after exposure to N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
mesh_terms: D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D003114:Colony-Forming Units Assay; D005347:Fibroblasts / Q000166:cytology; D006801:Humans; D066298:In Vitro Techniques; D008433:Mathematics; D008722:Methods; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D008954:Models, Biological; D009136:Muscular Dystrophies / Q000473:pathology; D013223:Statistics as Topic
chemical_list: D008769:Methylnitronitrosoguanidine