[Factors responsible for increasing the cytogenetic effectiveness of cyclophosphamide administered to irradiated animals. Frequency of chromosome aberrations in locally irradiated rat bone marrow cells].
A study was made of the frequency of chromosome aberrations induced by cyclophosphamide (CP) in the bone marrow of preirradiated rats (exposure of crus with the body shielded, and vice versa). A reliable evidence was obtained in favor of a change in the metabolism of CP in the irradiated body which was the cause of the enhancement of its cytogenetic action.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects*; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000494:pharmacology*; D008297:Male; D009153:Mutagens; D011833:Radiation Injuries, Experimental / Q000235:genetics*; D051381:Rats
D009153:Mutagens; D003520:Cyclophosphamide
Izuchenie prichin, obuslovlivaiushchikh usilenie tsitogeneticheskoĭ éffektivnosti tsiklofosfana pri vvedenii ego obluchennym zhivotnym. Issledovanie chastoty indutsirovannykh khromosomnykh aberratsiĭ v kletkakh kostnogo mozga krys pri lokal'nom obluchenii.