Clot-selective coronary thrombolysis with tissue-type plasminogen activator.
Coronary thrombolysis, an intervention that can abort the sequelae of acute myocardial infarction, was accomplished within 10 minutes in dogs by intravenous administration of clot-selective, tissue-type plasminogen activator. In addition to inducing clot lysis, this promising fibrinolytic agent restored intermediary metabolism and nutritional myocardial blood flow, detectable noninvasively with positron tomography, without inducing a systemic fibrinolytic state.
D000818:Animals; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000188:drug therapy*; D004285:Dogs; D005340:Fibrinogen / Q000032:analysis; D007263:Infusions, Parenteral; D007267:Injections; D010960:Plasminogen Activators / Q000008:administration & dosage / Q000627:therapeutic use*; D013300:Streptokinase / Q000008:administration & dosage / Q000627:therapeutic use; D013997:Time Factors; D014055:Tomography, Emission-Computed
D005340:Fibrinogen; D013300:Streptokinase; D010960:Plasminogen Activators