Spontaneous cytotoxic T cells in murine spleen-cell cultures. I. Some characteristics of effector and precursor cells.
Cytotoxic T cells that arise spontaneously in culture (SCTL) have been characterized using a sensitive plaque reduction (PR) assay. Although SCTL effector cells are highly susceptible to anti-Thy-1 antibody plus complement treatment, they are derived from precursor cells having very low levels of Thy-1 antigen. SCTL are barely detectable in cultures of thymus cells, bone marrow cells, and spleen cells from athymic nu/nu and very old mice. Since SCTL have some similarities to both natural killer cells and normal cytotoxic T cells, SCTL may represent a stage in the T-cell lineage that links these two forms of cytotoxicity.
D000375:Aging; D000818:Animals; D001853:Bone Marrow / Q000276:immunology; D002454:Cell Differentiation; D002478:Cells, Cultured; D003165:Complement System Proteins / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D007518:Isoantibodies / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology
D007518:Isoantibodies; C035678:anti-Thy antibody; D003165:Complement System Proteins