Wegener's granulomatosis complicated by diabetes insipidus.
We report a case of Wegener's granulomatosis complicated by cranial diabetes insipidus in which no evidence of local sinus erosion or intracranial granuloma was found. Unlike previously reported cases, the diabetes insipidus has not resolved despite successful treatment of the vasculitis. The patient is also unusual in that she had a prolonged 9-month prodromal period of seronegative polyarthritis before the appearance of typical systemic vasculitis and granuloma formation.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D003919:Diabetes Insipidus / Q000209:etiology*; D004359:Drug Therapy, Combination; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000150:complications* / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D010901:Pituitary Function Tests
D000305:Adrenal Cortex Hormones; D003520:Cyclophosphamide