title: [Efficacy of cimetidine in the prevention of aspiration pneumonia in paediatric anaesthesia].
abstract: In a prospective controlled study 63% of 150 children without prophylaxis were at risk of aspiration pneumonia in case of aspiration or regurgitation. In a second trial 10 mg/kg cimetidine orally 120 to 180 minutes prior to induction of anaesthesia proved to be a very effective prophylaxis. In small children up to 15 kg rectal application of 40 mg/kg cimetidine was even more effective than 10 mg/kg orally in reducing gastric volume. Premedication with cimetidine may be a practicable method for reducing the risk of aspiration pneumonia in paediatric anaesthesia.
mesh_terms: D000293:Adolescent; D000367:Age Factors; D000768:Anesthesia, General; D002648:Child; D002675:Child, Preschool; D002927:Cimetidine / Q000008:administration & dosage / Q000627:therapeutic use*; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D011015:Pneumonia, Aspiration / Q000517:prevention & control*; D011292:Premedication; D011446:Prospective Studies
chemical_list: D006146:Guanidines; D002927:Cimetidine
vernacular_title: Wirksamkeit von Cimetidin zur Prophylaxe der Aspirationspneumonie in der Kinderanästhesie.