Phototoxicity from furocoumarins (psoralens) of Heracleum laciniatum in a patient with vitiligo. Action spectrum studies on bergapten, pimpinellin, angelicin and sphondin.
Investigations on light reactions in a patient with vitiligo are presented. The minimal erythema dose (MED) in the UVB area was approximately 1/3 of that in persons of skin type II. The application of furocoumarins (psoralens) increased light tolerance by 1 MED at 300-310 nm. Action spectrum studies with furocoumarins from Heracleum laciniatum showed the following order of potency: bergapten, pimpinellin, angelicin and sphondin. The efficacy was highest at 325-350 nm, with maxima at 330-335 nm. Pimpinellin was recently found to be phototoxic, but an action spectrum of sphondin is reported for the first time.
D000078223:5-Methoxypsoralen; D000328:Adult; D000927:Anticonvulsants / Q000633:toxicity; D005260:Female; D011564:Furocoumarins / Q000633:toxicity*; D006801:Humans; D007364:Intercalating Agents / Q000633:toxicity; D007536:Isomerism; D008730:Methoxsalen / Q000031:analogs & derivatives / Q000633:toxicity; D010787:Photosensitivity Disorders / Q000209:etiology*; D010947:Plants, Toxic / Q000032:analysis*; D011829:Radiation Dosage; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D014149:Tranquilizing Agents / Q000633:toxicity; D014466:Ultraviolet Rays / Q000009:adverse effects; D014820:Vitiligo / Q000150:complications*
D000927:Anticonvulsants; D011564:Furocoumarins; D007364:Intercalating Agents; D014149:Tranquilizing Agents; C039410:sphondin; D000078223:5-Methoxypsoralen; C011659:angelicin; C039409:pimpinellin; D008730:Methoxsalen