Levels of ampicillin and doxycycline in human oviduct mucosa and serum.
A common treatment for salpingitis today includes ampicillin (AMPI) and doxycycline (DC), the former against Neisseria gonorrhoeae and the latter against Chlamydia trachomatis. The concentrations of doxycycline in oviduct mucosa were found about equal to that of serum and well above the minimum inhibitory concentrations (MIC's) for the bacteriae in question. The concentration of AMPI in the oviduct mucosa was only about 1/40 of that in serum, i.e. 1/10 of the MIC, which jeopardizes the effectivity of AMPI in the treatment of salpingitis.
D000328:Adult; D000368:Aged; D000667:Ampicillin / Q000097:blood / Q000378:metabolism*; D004318:Doxycycline / Q000097:blood / Q000378:metabolism*; D005187:Fallopian Tubes / Q000378:metabolism*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009092:Mucous Membrane / Q000378:metabolism
D000667:Ampicillin; D004318:Doxycycline