Hydralazine-induced relapsing polychondritis-like syndrome. Report of a case with severe chronic laryngeal complications.
Relapsing polychondritis is a rare disease of uncertain etiology, characterized by inflammation of cartilage. Cartilage of the respiratory tract is engaged in more than half of all cases. Hydralazine-induced systemic lupus erythematosis (SLE) is a well known disease. Females who are slow acetylators and are HLA-DR4 positive when treated with hydralazine are at serious risk of contracting SLE syndrome. We describe here a woman, treated for 10 years with hydralazine, who was a slow acetylator and was HLA-DR4 positive and who presented with a relapsing polychondritis and ultimately required a permanent tracheostoma. To our knowledge, this is the first published case of relapsing polychondritis induced by hydralazine.
D005260:Female; D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D006801:Humans; D006830:Hydralazine / Q000009:adverse effects*; D007818:Laryngeal Diseases / Q000139:chemically induced*; D007827:Laryngitis / Q000139:chemically induced; D008173:Lung Diseases, Obstructive / Q000209:etiology; D008297:Male; D008875:Middle Aged; D011081:Polychondritis, Relapsing / Q000139:chemically induced* / Q000175:diagnosis / Q000276:immunology; D013577:Syndrome
D015804:HLA-DR4 Antigen; D000949:Histocompatibility Antigens Class II; D006830:Hydralazine