[Non-extractible residues of aryl-14C-albendazole in sheep].
The location of the intractable residues of 14C-ring labelled-albendazole has been investigated in the sheep. Numerous biochemical compounds have been isolated: pulmonary CO2, blood dextrose, glycogen, triglycerides, cholesterol, hemoglobin, plasmatic, cytosolic and microsomal proteins, nucleic acids . . . No incorporation into intermediary metabolisms has been put into evidence. On the contrary, a significant covalently bound radioactivity has been observed on hepatic and plasmatic proteins. No covalent binding to hepatic DNA seems to be produced.
D000818:Animals; D000871:Anthelmintics / Q000378:metabolism*; D001711:Biotransformation; D001798:Blood Proteins / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D008099:Liver / Q000378:metabolism; D011485:Protein Binding; D012756:Sheep / Q000378:metabolism*; D013347:Subcellular Fractions / Q000378:metabolism
D000871:Anthelmintics; D001798:Blood Proteins
Investigations sur les résidus non-extractibles de l'aryl-14C-albendazole chez le mouton.