title: [Fundamental and clinical studies on T-1982 (cefbuperazone) in the field of obstetrics and gynecology].
abstract: T-1982 (cefbuperazone), a new cephem antibiotic, was fundamentally and clinically studied in the field of obstetrics and gynecology. The following results were obtained. The concentrations of the drug in arterial and venous blood, and genitalia following intravenous drip infusion were measured. The results demonstrated favourable transfer of the drug into various internal genital organs. Eleven patients with bacterial infections were treated with T-1982. The therapeutic results were markedly effective in 2 and good in 9 cases, therefore the effective rate was 100%. No side effects were noted in any cases. It is therefore, presumed, that T-1982 is a useful drug for infectious diseases in the field of obstetrics and gynecology although the number of subjects was not so large in this study.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002513:Cephamycins / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008875:Middle Aged; D010053:Ovary / Q000378:metabolism; D010538:Peritonitis / Q000188:drug therapy; D014599:Uterus / Q000378:metabolism; D014847:Vulvitis / Q000188:drug therapy
chemical_list: D002513:Cephamycins; C035978:cefbuperazone