[Dissolution determination in the rotating flask model. Effect of rotation rate and fluid volume on the solubility determination of standard test tablets in the Resotest dissolution tester].
The influence of two important factors, the rotational speed and the fluid volume within the system, on the release characteristics of prednisone-test tablets in the rotating flask dissolution-tester (Resotest-apparatus after Koch) has been investigated. As a result, standard conditions for dissolution experiments with the rotating flask model, i.e. a mean rotation number of 30 r.p.m. and an actual fluid volume of 500 ml, are proposed.
D002626:Chemistry, Pharmaceutical / Q000295:instrumentation; D012995:Solubility; D013607:Tablets; D013997:Time Factors
D013607:Tablets
Auflösungsbestimmungen im Drehkolbenmodell. Einfluss von Rotationsgeschwindigkeit und Flüssigkeitsvolumen auf das Auflösungsverhalten von Standard-Testtabletten im Resotest-Dissolutionstester.