Cavernosal alpha-blockade: a new technique for investigating and treating erectile impotence.
Intravacernosal injection of phenoxybenzamine, in a dose too small to have significant general effects, caused full erection lasting between half an hour and 30 hours in 30 of 4 potent men (2 normal, 2 anorgasmic) and in 6 of 11 impotent men. In the remaining potent man and 3 of the remaining eleven impotent men have had sexual intercourse, for the first time for months or years, while under the drug. The practical implications of this new discovery are discussed.
D000328:Adult; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D007267:Injections; D008297:Male; D008875:Middle Aged; D010413:Penis; D010643:Phenoxybenzamine / Q000008:administration & dosage*; D010646:Phentolamine / Q000008:administration & dosage; D013997:Time Factors
D010643:Phenoxybenzamine; D010646:Phentolamine