Isochromosome 17q in cell lines of two cases of B cell chronic lymphocytic leukemia.
The cytogenetic study of lymphocytes stimulated by EB virus in two cases of B-CLL revealed an isochromosome 17q. This abnormality, well known in CML during the stage of blastic transformation, may not be specific to myeloid proliferation as it is also observed in malignant lymphomas and B- or T-CLL. The anomaly does not appear to have the same prognostic nature as in CML.
D000368:Aged; D001402:B-Lymphocytes; D002869:Chromosome Aberrations; D002902:Chromosomes, Human, 16-18; D006801:Humans; D007621:Karyotyping; D007945:Leukemia, Lymphoid / Q000235:genetics*; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male