title: Cerebrospinal fluid rhinorrhoea during treatment of pituitary tumours with bromocriptine.
abstract: Bromocriptine is widely used in the treatment of hyperprolactinaemia. It has also been shown to be effective in reducing the size of large pituitary tumours, particularly those secreting prolactin. We describe CSF rhinorrhoea in two such patients during treatment with bromocriptine and believe that this complication developed as a result of contraction of the tumour exposing a defect in the sella floor. The possibility of this complication, especially in patients with downward extension of tumour, should be noted.
mesh_terms: D000328:Adult; D001971:Bromocriptine / Q000009:adverse effects* / Q000627:therapeutic use; D002559:Cerebrospinal Fluid Rhinorrhea / Q000209:etiology*; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D010911:Pituitary Neoplasms / Q000188:drug therapy*; D011388:Prolactin / Q000097:blood; D012886:Skull / Q000000981:diagnostic imaging; D014057:Tomography, X-Ray Computed
chemical_list: D001971:Bromocriptine; D011388:Prolactin; D013006:Growth Hormone