[Antiproliferative action of 5'-S-isobutyladenosine in vitro and in vivo on normal and neoplastic mouse cells].
Antiproliferative activity of 5'-deoxy-5'-S-isobutylthioadenosine (SIBA) was studied in mouse tumor and medullary cells in vitro and in vivo. Essential differences were found in the antiproliferative action of SIBA on medullary and tumor cells in vivo and in vitro. It was shown that in vitro SIBA drastically inhibited DNA synthesis (by more than 80-90%) in all cells under test, whereas in vivo it stimulated 3H-thymidine incorporation into DNA of the ascites tumor cells and medullary cells of mice with lymphoma NK/Ly.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects*; D004247:DNA / Q000096:biosynthesis; D004273:DNA, Neoplasm / Q000096:biosynthesis; D003839:Deoxyadenosines / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D007942:Leukemia, Experimental / Q000473:pathology*; D051379:Mice; D013872:Thionucleosides / Q000494:pharmacology*
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D003839:Deoxyadenosines; D013872:Thionucleosides; C013919:5'-deoxy-5'-S-isobutylthioadenosine; D004247:DNA
Antiproliferativnoe deĭstvie 5'-S-izobutiladenozina in vitro i in vivo na normal'nye i opukholevye kletki mysheĭ.