title: The effects of fibrin tissue adhesive on the middle ear.
abstract: This study investigated the effects of fibrin glue ('Tissucol', Immuno Pty. Ltd.) in the middle and inner ear. Small amounts of the adhesive were used in 36 operations performed on 18 rabbits. The light microscopic examination of these ears four, eight and 12 weeks after surgery showed that the adhesive was well tolerated and that it did not have any toxic effect on the middle ear or membranous labyrinth. The fibrin tissue adhesive can therefore safely be used to facilitate reconstructive middle-ear surgery and, with the aid of fascia, also for the closure of labyrinthine fistulae; or to achieve a definite seal of oval window niche after stapes surgery.
mesh_terms: D000818:Animals; D004338:Drug Combinations / Q000494:pharmacology; D007758:Ear, Inner / Q000187:drug effects / Q000601:surgery; D004432:Ear, Middle / Q000187:drug effects* / Q000601:surgery; D005176:Factor XIII / Q000494:pharmacology*; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000494:pharmacology*; D011817:Rabbits; D013917:Thrombin / Q000494:pharmacology*; D014014:Tissue Adhesives / Q000494:pharmacology*
chemical_list: D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D014014:Tissue Adhesives; D005340:Fibrinogen; D005176:Factor XIII; D013917:Thrombin