Mutagenesis of amino acid pyrolysis products in Chinese hamster V79 cells.
The mutagenic effects of Trp-P-1, Trp-P-2, Glu-P-1, Glu-P-2, Lys-P-1, MeA alpha C, A alpha C, MeIQ and IQ on Chinese hamster V79 cells with or without X-irradiated Syrian hamster embryo cells were examined. Of these products, only Trp-P-2 and Lys-P-1 induced ouabain-resistant mutants of Chinese hamster V79 cells in a dose-related fashion; X-irradiated Syrian hamster embryo cells were required for the mutagenicity of Lys-P-1, but not for that of Trp-P-2. None of the other pyrolysis products examined was mutagenic with or without X-irradiated Syrian hamster embryo cells.
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D004351:Drug Resistance; D004622:Embryo, Mammalian; D008168:Lung; D008647:Mesocricetus; D008769:Methylnitronitrosoguanidine / Q000633:toxicity; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D010042:Ouabain / Q000633:toxicity
D000596:Amino Acids; D009153:Mutagens; D008769:Methylnitronitrosoguanidine; D010042:Ouabain