title: Studies on lamoxactam penetration into the aqueous humor of the human eye.
abstract: Eighteen patients scheduled for surgical lens removal were assigned to six groups of three patients each. These patients received 25 mg/kg lamoxactam i. v. 30 to 180 min prior to surgery. In the course of the operation, aqueous humor was obtained and a serum sample taken to determine the antibiotic concentration. The mean peak serum level was 154.5 mg/l after 30 min; it was still 46.4 mg/l after 3 h. The lamoxactam concentrations in the aqueous humor increased slowly. Peak levels after 2 h were 4.2 mg/l. The ratio of aqueous humor level: serum level after 1 h was 4.7%, after 1.5 h 5.3% and after 2 h 6.9%. The ratio then remained constant up to the third hour. Aside from some gram-positive bacterial species and Pseudomonas species, all relevant microorganisms which cause eye infections are included in lamoxactam's spectrum of susceptibility.
mesh_terms: D000368:Aged; D001082:Aqueous Humor / Q000032:analysis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D009070:Moxalactam / Q000032:analysis / Q000097:blood / Q000494:pharmacology*
chemical_list: D009070:Moxalactam