title: Plasma cell myeloma showing progressive bone destruction during long-term clinical remission.
abstract: A case of plasma cell myeloma initially producing Bence Jones protein of lambda type was presented. BJ protein disappeared within two months of cyclophosphamide and betamethasone administration. A complete remission continued for the following 2 years and 8 months with no medication, although the patient insidiously developed osteolytic lesions. The discrepancy of long-term negative BJP and clinical remission without medication and progressive bone destruction was reported.
mesh_terms: D000328:Adult; D001536:Bence Jones Protein / Q000652:urine*; D001623:Betamethasone / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy / Q000652:urine*; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D010950:Plasma Cells / Q000648:ultrastructure; D010954:Plasmacytoma / Q000188:drug therapy / Q000652:urine*
chemical_list: D003520:Cyclophosphamide; D001536:Bence Jones Protein; D001623:Betamethasone