A function for human T200 in natural killer cytolysis.
The ability of an antihuman T200 monoclonal antibody, F2.5, to specifically inhibit in vitro human natural killer cell-mediated lysis of K562 target cells is demonstrated. No inhibition by the F2.5 antibody of a cytotoxic T lymphocyte response to autologous virus-infected cells could be shown. Direct binding studies indicated that F2.5 antibody-coated effector cells had a reduced capacity to bind to K562 target cells, suggesting that T200 has a function in the recognition and binding of the natural killer cell to its target cell. This is the first time a role for human T200 and identification of a functional natural killer cell receptor have been described.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000941:Antigens / Q000276:immunology*; D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D004915:Leukemia, Erythroblastic, Acute / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008970:Molecular Weight; D009369:Neoplasms / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000911:Antibodies, Monoclonal; D000941:Antigens