[Effect of an enkephalin-like tetrapeptide on the food instrumental behavior of rats].
An enkephalin-like tetrapeptide (subcutaneous, intraperitoneal and intraventricular injections) disturbs the goal-oriented food instrumental behavior of rats by decreasing the number of adequately performed instrumental reactions. In addition to these disorders, intraventricular microinjections entail an increase in the number of inadequate, incomplete behavioral reactions. Besides, injection of the tetrapeptide evokes specific disorders of motor activity, which manifest in the occurrence in rats of stretches, "duck-like step", motor stereotypy, arching of the tail, changes in the tone of abdominal muscles, etc. The tetrapeptide effects described were not inhibited by narcan, remaining unchanged for 3.5-5 months following a single injection of the tetrapeptide.
D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009842:Oligopeptides / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats
D009842:Oligopeptides; D009270:Naloxone; C037379:tyrosyl alanyl-glycyl-phenylalaninamide
Vliianie énkefalinopodobnogo tetrapeptida na pishchevoe instrumental'noe povedenie krys.