Activation of the complement system and accumulation of hemoglobin-haptoglobin complexes in plasma during an adverse reaction to penicillin treatment.
A patient treated with penicillin intravenously developed a serum sickness-like reaction. Classical pathway complement (C) activation was indicated by quantitation of the split products C3c and C3d as well as demonstration of C4 conversion. Circulating immune complexes could, however, not be detected by the solid-phase Clq and PEG-precipitation methods. A concomitant accumulation of circulating hemoglobin-haptoglobin complexes and a marked fall in serum-fibronectin concentrations suggested saturation of the reticuloendothelial system. The plasma became a deep-red color, and a diffuse intravascular coagulation followed. The patient recovered completely upon discontinuation of penicillin administration.
D000936:Antigen-Antibody Complex / Q000032:analysis; D001777:Blood Coagulation / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D003167:Complement Activation / Q000187:drug effects*; D003176:Complement C3 / Q000032:analysis; D015933:Complement C3d; D003171:Complement Pathway, Classical / Q000187:drug effects*; D003404:Creatinine / Q000097:blood; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005353:Fibronectins / Q000032:analysis; D006242:Haptoglobins / Q000032:analysis*; D006454:Hemoglobins / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010400:Penicillin G / Q000009:adverse effects*
D000936:Antigen-Antibody Complex; D003176:Complement C3; D005338:Fibrin Fibrinogen Degradation Products; D005353:Fibronectins; D006242:Haptoglobins; D006454:Hemoglobins; D015933:Complement C3d; D003404:Creatinine; D010400:Penicillin G