title: Quantitative analysis of the lateral geniculate nucleus in the mutant microphthalmic rat.
abstract: A quantitative analysis of the lateral geniculate nucleus was carried out in the mutant microphthalmic rat. In the dorsal lateral geniculate nucleus (LGNd) of the microphthalmic rat we found the total volume and neuronal population were reduced by 45 and 68% of normal values, respectively. The size of normal LGNd neurons was 8 to 20 microns and that of mutant LGNd cells from 6 to 16 microns. Neurons of the normal LGNd were medium-size and round or oval, and their cell bodies were filled with Nissl substance. Microphthalmic LGNd neurons, on the other hand, had narrow cytoplasmic spaces with few Nissl granules, and pale cell nuclei. In the microphthalmic rat, the lateral part of the ventral lateral geniculate nucleus (LGNvl) also showed a marked reduction in the total volume and neuronal population which were 42 and 76% of normal values, respectively. The size of normal LGNvl neurons was 8 to 20 microns and that of the microphthalmic neurons from 6 to 16 microns. These findings suggested that a marked reduction in the size of the LGNd and LGNvl in the mutant can be attributed to a decrease in neuronal population to a diminution of cell size.
mesh_terms: D000818:Animals; D005829:Geniculate Bodies / Q000473:pathology*; D008850:Microphthalmos / Q000235:genetics / Q000473:pathology*; D051381:Rats; D011922:Rats, Mutant Strains / Q000033:anatomy & histology*; D012016:Reference Values