Role of glucocorticoids on the maturation of brush border enzymes in fetal rat gut endoderm.
Heterospecific recombinants between fatal rat intestinal endoderm and chick mesenchyme, and also undissociated fetal rat intestine, were submitted to different hormonal environments. The present study shows that exogenously-supplied dexamethasone in organ culture, like endogenous hormones provided by the adult rat (grafting experiments) led to similar qualitative and quantitative results, i.e., a 9-fold stimulation of maltase and a precocious induction of sucrase activity in comparison with an hormonal conditions.
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D004707:Endoderm / Q000187:drug effects / Q000648:ultrastructure*; D005260:Female; D008871:Microvilli / Q000187:drug effects / Q000201:enzymology; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D003907:Dexamethasone