[Decrease in the serum level of the C3 complement component in noninsulin dependent diabetes of recent onset].
Complement components C3, C4 and C3A were measured by immuno-diffusion in plasma of 36 recent onset insulin-dependent diabetics (IDD) and compared to plasma complement levels of 19 long-standing IDD and 18 non diabetic controls. A significant decrease of C3 and a mild increase of C3A was found in recent-onset diabetes group. However these variations could not be correlated with IgG-islet cell antibodies, C3--fixing islet cell antibodies or A--B HLA antigens. No significant difference was found between long-standing IDD and controls for the 3 complement components. In conclusion, the decrease of C3, found in 30% of recent onset IDD, might be due to increase complement consumption either by the insulitis process or by circulating immune complexes.
D000293:Adolescent; D000328:Adult; D002648:Child; D003176:Complement C3 / Q000032:analysis*; D015926:Complement C3a; D003181:Complement C4 / Q000032:analysis; D003920:Diabetes Mellitus / Q000276:immunology* / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D003176:Complement C3; D003181:Complement C4; D015926:Complement C3a
Diminution du taux sérique du composant c3 du complément dans le diabète insulinodépendant récent.