[Effect of clofibrate on the polypeptide content of a purified fraction of rat liver peroxisomes].
The effects of the hypolipaemic agent clofibrate on rat liver peroxisomes and of its "ghosts" obtained by solubilization of peroxisomal matrix peptides were studied by Na-DS polyacrylamide gel electrophoresis. Clofibrate significantly altered the amount of some peroxisomal polypeptides which is correlated with its effect on the enzyme composition of these organelles. The possibility of identification of polypeptides in gels with subunits of some peroxisomal enzymes (catalase, urate oxidase, components of fatty acid beta-oxidation chain, etc.) is discussed.
D000818:Animals; D002994:Clofibrate / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008830:Microbodies / Q000187:drug effects / Q000378:metabolism*; D010455:Peptides / Q000302:isolation & purification / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D010455:Peptides; D002994:Clofibrate
Vliianie klofibrata na polipeptidnyĭ sostav ochishchennoĭ fraktsii peroksisom pecheni krys.