Evidence for the existence of an IL-2-like lymphocyte growth promoting factor in a bony fish, Cyprinus carpio.
Activity promoting the growth of carp T-like cells has been found in supernatants of mitogen (PHA)- and alloantigen (MLR)-stimulated carp leukocyte cultures. Activity level in culture supernatants was elevated by phorbol myristate acetate. Proliferation of carp T-like lymphoblasts was also promoted in the presence of Il-2-containing supernatants of mammalian origin. The significance of these findings is discussed.
D000818:Animals; D002347:Carps / Q000502:physiology*; D003530:Cyprinidae / Q000502:physiology*; D007376:Interleukin-2 / Q000032:analysis / Q000494:pharmacology / Q000502:physiology*; D007962:Leukocytes / Q000032:analysis* / Q000187:drug effects; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000187:drug effects; D008322:Mammals / Q000502:physiology; D010835:Phytohemagglutinins / Q000494:pharmacology; D013045:Species Specificity; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D007376:Interleukin-2; D010835:Phytohemagglutinins; D013755:Tetradecanoylphorbol Acetate