title: [Pharmacokinetics of amiodarone in one case of acute oral intoxication].
abstract: A wealth of data about the clinical use and the therapeutic efficacy of chronic treatment with amiodarone has been reported, while the acute effects of this agent are less known. In one case of acute oral intoxication with 8 g of amiodarone for suicidal purposes, we have investigated the pharmacokinetics of amiodarone, the thyroid function and the variations of some clinical parameters, such as heart rate and QT interval. Other possible side-effects have been looked for. We have not observed substantial pharmacokinetic differences between our case and studies carried out after chronic oral or intravenous administration. Unlike chronic administration, the acute oral load was not followed by the appearance of toxic effects. The absence of toxic phenomena can be explained by the poor bioavailability of amiodarone, which is known to require long periods for a complete distribution to the tissues and target organs.
mesh_terms: D000328:Adult; D000638:Amiodarone / Q000378:metabolism / Q000506:poisoning*; D001572:Benzofurans / Q000506:poisoning*; D005260:Female; D006801:Humans; D013405:Suicide
chemical_list: D001572:Benzofurans; D000638:Amiodarone
vernacular_title: Farmacocinetica dell'amiodarone in un caso di intossicazione acuta (8 grammi per os).