Peripheral lymphocyte response to PHA and T cell population among atomic bomb survivors.
The percentage of T lymphocytes of atomic bomb survivors showed no change as a function of age or exposure dose. The percentage of T cells was slightly lower in malignant-tumor patients than in the control group, but was significantly higher in the group with chromosomal aberrations than in the control group. The percentages of phytohemagglutinin (PHA)-induced transformation of peripheral lymphocytes decreased significantly with age in the 0 rad control group and the 200+ rad exposure group, particularly so in the latter. The malignant-tumor group also showed lower percentages of PHA-induced transformation than the control group. The percentages of PHA-induced transformation of lymphocytes of the chromosomal-aberration group were significantly depressed as compared with that of the control group.
D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007564:Japan; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000276:immunology*; D009689:Nuclear Warfare; D010835:Phytohemagglutinins / Q000494:pharmacology; D011829:Radiation Dosage; D012397:Rosette Formation; D013534:Survival; D013601:T-Lymphocytes / Q000276:immunology*
D010835:Phytohemagglutinins