Regulation of uteroglobin synthesis and conservation of progesterone and estrogen receptors in immature rabbit uterus during prolonged progesterone treatment.
Daily progesterone administration (1.33 mg/kg body weight) to immature rabbits brought about an initial increase in the uterine content of uteroglobin which, however, subsided when progesterone treatment was continued for 10 days. During this treatment period progesterone did not lose its own uterine receptors nor did it lose its inhibitory effect on the accumulation of occupied nuclear estrogen receptors. Since immature rabbits were used, the decrease of uteroglobin concentration cannot be explained by inhibitory effects of endogenous estrogens. The results suggest that termination of uteroglobin secretion may be a selective and inherent effect of progesterone itself.
D000818:Animals; D003600:Cytosol / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D005260:Female; D006023:Glycoproteins / Q000096:biosynthesis*; D007700:Kinetics; D011282:Pregnenediones / Q000378:metabolism; D011374:Progesterone / Q000494:pharmacology*; D045167:Progesterone Congeners / Q000378:metabolism; D011817:Rabbits; D011960:Receptors, Estrogen / Q000187:drug effects / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000187:drug effects / Q000378:metabolism*; D012741:Sexual Maturation; D014598:Uteroglobin / Q000096:biosynthesis*; D014599:Uterus / Q000187:drug effects / Q000502:physiology*
D006023:Glycoproteins; D011282:Pregnenediones; D045167:Progesterone Congeners; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C020175:16 alpha-ethyl-21-hydroxy-19-nor-4-pregnene-3,20-dione; D011374:Progesterone; D004958:Estradiol; D014598:Uteroglobin