Prostaglandins and the mode of action of antipyretic analgesic drugs.
Antipyretic analgesics account for more than 95 percent of the analgesic market. The most important agents of this group--salicylates, aniline derivatives such as acetaminophen, and nonacidic pyrazolones--have been used for almost 100 years. Nevertheless, their therapeutic mechanisms and the molecular causes of the most important side effects remain unclear. Several common theories are discussed and challenged.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects / Q000378:metabolism; D007249:Inflammation / Q000503:physiopathology; D010146:Pain / Q000503:physiopathology; D011448:Prostaglandin Antagonists; D011453:Prostaglandins / Q000096:biosynthesis / Q000502:physiology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011448:Prostaglandin Antagonists; D011453:Prostaglandins