Endotoxin-induced in vitro release of interleukin-1 by cancer patients' monocytes: relation to stage of disease.
The in vitro release of IL-1 by monocytes in response to endotoxin was subnormal in many patients with breast cancer, malignant melanoma or colorectal cancer but not in patients with benign tumors of the breast or colon. In each of these groups, IL-1 release was low in patients with early cancer, normal in patients with regional metastases, and low in patients with disseminated cancer.
D000328:Adult; D000818:Animals; D001943:Breast Neoplasms / Q000276:immunology / Q000473:pathology; D002455:Cell Division; D002478:Cells, Cultured; D003110:Colonic Neoplasms / Q000276:immunology / Q000473:pathology; D004731:Endotoxins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000276:immunology*; D008297:Male; D008545:Melanoma / Q000276:immunology / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology; D012004:Rectal Neoplasms / Q000276:immunology / Q000473:pathology; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology; D013601:T-Lymphocytes / Q000166:cytology
D004731:Endotoxins; D007375:Interleukin-1