[Effect of a flavinoid (4-methylesculetin) on the response of isolated calf coronary arteries to histamine in the presence of indomethacin].
The aim of this work is to study the mechanism by which 4-methylesculetin (4-Me) cause the relaxation or inhibit the histamine induced contraction in the smooth muscle. The effect of 4-Me, alone or associated with ascorbic-acid, on basal tone and histamine induced contraction of isolated coronary strips have been studied. Experiments have been carried out in the presence of indomethacin (IN), specific inhibitor of prostaglandin synthetase. IN-decreased, but did not abolished, the 4-Me induced relaxation and reduced or suppressed the depressive effect of 4-Me on the histamine dependent contraction. Therefore, it seems reasonable to conclude that the 4-Me influence could be mediated by prostaglandins release in the smooth muscle.
D000818:Animals; D002417:Cattle; D003331:Coronary Vessels / Q000187:drug effects; D006632:Histamine / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D012603:Scopoletin / Q000494:pharmacology*; D014468:Umbelliferones / Q000494:pharmacology*
D014468:Umbelliferones; D006632:Histamine; D012603:Scopoletin; D007213:Indomethacin
Influenza di un flavonoide (4-metilesculetolo) sulla risposta di arterie coronarie di vitello isolate all'istamina in presenza di indometacina.