[Antitumor effect of a tumor-cell neuraminidase vaccine].
The effect of neuraminidase vaccine of CBA mouse sarcoma cells caused by simian adenovirus SA7 (C8) on growth parameters of transplanted sarcoma in a syngeneic system was studied. Inoculation of the vaccine was found to inhibit tumor growth. This effect was more marked in a group of animals given tumor cells after preliminary vaccination. There was no correlation between tumor growth parameters and cytotoxic activity of spleen cells assesses in the cytotoxicity test by 51Cr release in the groups of vaccinated and control animals. It is concluded that the treatment of tumor cells with neuraminidase increases their immunogenicity. The cytotoxic activity of spleen cells in vaccinated animals appears earlier and persists longer.
D000261:Adenoviruses, Simian / Q000276:immunology; D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D004353:Drug Evaluation, Preclinical; D051379:Mice; D008808:Mice, Inbred CBA; D009368:Neoplasm Transplantation; D009439:Neuraminidase / Q000008:administration & dosage* / Q000276:immunology; D012513:Sarcoma, Experimental / Q000276:immunology* / Q000517:prevention & control; D013997:Time Factors; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000276:immunology
D014765:Viral Vaccines; D009439:Neuraminidase
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