Diminished adherence of sickle erythrocytes to cultured vascular endothelium by piracetam.
Erythrocytes from both normal and sickle cell donors were incubated on a bed of cultured rat vascular endothelial cells. Although the adherence of the erythrocytes to the endothelial cells was equivalent for both classes of donor, addition of 1.5 mM piracetam significantly decreased this adherence regardless of donor.
D000755:Anemia, Sickle Cell / Q000097:blood*; D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects*; D002478:Cells, Cultured; D004727:Endothelium / Q000502:physiology; D004913:Erythrocytes, Abnormal / Q000187:drug effects; D006801:Humans; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats
D011760:Pyrrolidinones; D010889:Piracetam