Renal excretion of fluoride during water diuresis and induced urinary pH-changes in man.
Fluoride renal clearance (CF) was studied in young healthy subjects with standard clearance technique following administration of 3 mg F as a 30-min constant infusion. High urinary flow rates were induced and experiments were performed under both urinary alkaline and acidic conditions. The data showed that a high urinary flow resulted in maximum fluoride clearance. High water diuresis may therefore be an important part in the treatment of acute fluoride intoxication.
D000328:Adult; D004231:Diuresis; D005260:Female; D005458:Fluoride Poisoning / Q000628:therapy; D005459:Fluorides / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate
D005459:Fluorides