Role of a surface glycoprotein in the control of protein-mediated attachment of adult hepatocytes.
In order to gain insight into the molecular mechanism of adhesion of adult Wistar rat hepatocytes to protein substrates, we identified a Mr 150 000 glycoprotein that is redistributed in the surface membrane and appears to be increased beneath cells when attachment is markedly enhanced in the presence of adsorbed proteins from fetal calf serum (FCS). It is suggested that the attachment change may be due to recruitment of this glycosylated component into cell-substrate contact sites.
D000818:Animals; D001798:Blood Proteins / Q000502:physiology; D002448:Cell Adhesion; D003208:Concanavalin A / Q000378:metabolism; D006023:Glycoproteins / Q000502:physiology*; D008099:Liver / Q000166:cytology*; D008565:Membrane Proteins / Q000502:physiology*; D008970:Molecular Weight; D051381:Rats; D011919:Rats, Inbred Strains
D001798:Blood Proteins; D006023:Glycoproteins; D008565:Membrane Proteins; D003208:Concanavalin A