Inhibitory effect of Distamycin-A and a pyrazino-pyrazine derivative on tomato spotted wilt virus.
Distamycin-A hydrochloride, a synthetic antibiotic, and 2,3-dihydroxy-6-bromo-pyrazino (2,3-beta) pyrazine derivative, were used against tomato spotted wilt virus (TSWV) in tobacco plants. The drugs were applied to the leaves at concentrations of 200 and 400 mg/l. The results showed that both drugs delayed virus spread within the plant, retarding the appearance of systemic symptoms. A virus recovery test, carried out on primary leaves of Phaseolus vulgaris cv. Manteiga, showed that TSWV replication was markedly inhibited by the pyrazino-pyrazine derivative at concentrations of 200 and 400 mg/l and, to a lower extent, by Dystamycin-A at 400 mg/l.
D000998:Antiviral Agents / Q000494:pharmacology*; D004214:Distamycins / Q000494:pharmacology*; D010942:Plant Viruses / Q000187:drug effects* / Q000502:physiology; D010947:Plants, Toxic; D011719:Pyrazines / Q000494:pharmacology*; D011758:Pyrroles / Q000494:pharmacology*; D013997:Time Factors; D014026:Nicotiana / Q000382:microbiology; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D004214:Distamycins; D011719:Pyrazines; D011758:Pyrroles; C039094:2,3-dihydroxy-6-bromopyrazino(2,3b)pyrazine; C030000:stallimycin