Neuroblastoma, tuberous sclerosis, and subependymal giant cell astrocytoma.
A patient with Stage III paratesticular neuroblastoma diagnosed in infancy was treated with radiotherapy and chemotherapy. Typical depigmented "ash leaf" skin lesions of tuberous sclerosis appeared during early childhood. At 7 years of age he underwent craniotomy for a subependymal giant cell astrocytoma. The occurrence of neuroblastoma, tuberous sclerosis, and astrocytoma is unique, and supports the suggested relationship between neural crest tumors and hamartoma syndromes.
D001932:Brain Neoplasms / Q000150:complications*; D002648:Child; D005910:Glioma / Q000150:complications*; D006801:Humans; D008297:Male; D009378:Neoplasms, Multiple Primary; D009447:Neuroblastoma / Q000150:complications*; D013736:Testicular Neoplasms / Q000150:complications*; D013997:Time Factors; D014402:Tuberous Sclerosis / Q000150:complications*