Growth and metabolic alterations after submandibular sialadenectomy in male mice.
Because the submandibular salivary glands of male mice are rich in growth factors such as epidermal growth factor and nerve growth factor, and because there are sporadic reports of sialadenectomized mice showing growth retardation and endocrine abnormalities, we studied oxidative metabolism and fertility after submandibular sialadenectomy. Despite similar intake of food, male mice (n = 60) deprived of submandibular saliva, either by duct ligation or gland excision, initially weighed 12-13% less than the sham controls and had a slower rate of growth (P less than 0.001). After 5 mo, mice with duct ligation caught up with the sham-operated mice, but the differences compared with submandibular-sialadenectomized mice were still apparent at 32 wk (P less than 0.001). The mean respiratory quotient of submandibular-sialadenectomized and duct-ligated mice was 0.71 instead of 0.88 as in the shams at 10, 20, and 30 wk after operation (P less than 0.01). No effect on fecundity was observed in either male or female mice following submandibular sialadenectomy.
D000375:Aging; D000818:Animals; D001835:Body Weight; D004815:Epidermal Growth Factor / Q000502:physiology; D005298:Fertility; D006128:Growth; D008297:Male; D051379:Mice; D009414:Nerve Growth Factors / Q000502:physiology; D010101:Oxygen Consumption; D013363:Submandibular Gland / Q000502:physiology*
D009414:Nerve Growth Factors; D004815:Epidermal Growth Factor