Anti-ribonucleoprotein antibodies in inflammatory rheumatic diseases.
Of 472 consecutive patients with inflammatory rheumatic diseases attending a unit responsible for the treatment of rheumatoid diseases, only 12 patients were found to have anti-ribonucleoprotein (RNP) antibodies. Of these, 5 patients fulfilled the criteria for the diagnosis of systemic lupus erythematosus (SLE) and 7 those of rheumatoid arthritis. Joint symptoms were the predominant clinical features and caused severe deformities requiring operations in most cases. One anti-RNP-positive SLE patient died of chronic active hepatitis.
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000276:immunology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000175:diagnosis / Q000276:immunology; D012216:Rheumatic Diseases / Q000276:immunology*; D012261:Ribonucleoproteins / Q000276:immunology*
D000974:Antibodies, Antinuclear; D012261:Ribonucleoproteins