Preliminary characterization of the cells causing an H-2-restricted GVH reaction.
An H-2-restricted graft-versus-host reaction can be demonstrated when irradiated bone marrow-protected recipients receive injections of cells from radiation chimeras. The cells responsible are Thy-1-positive, thymus-dependent, radiation-sensitive and pass through a nylon wool column, i.e., they are T cells. Treatment of the cells with anti-Lyt-1 or anti-Lyt-2 serum and complement reduces but does not eliminate the activity which can be eliminated by treatment with both antisera. Combining anti-Lyt-1-treated and anti-Lyt-2-treated cells does not restore the original activity.
D000818:Animals; D001853:Bone Marrow / Q000276:immunology / Q000528:radiation effects; D003433:Crosses, Genetic; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006087:Graft vs Host Reaction; D006183:H-2 Antigens / Q000276:immunology*; D007518:Isoantibodies / Q000276:immunology; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D011828:Radiation Chimera; D011836:Radiation Tolerance; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects
D006183:H-2 Antigens; D007518:Isoantibodies; C029805:Lyt antibodies