Immature chicken B cells with immunocompetence restricted to IgM type do not elicit the formation of germinal centres.
Chickens depleted of both T and B cells were restored with T cells and with immature B cells capable of producing IgM only, and immunized with sheep red blood cells. These chickens developed strikingly few germinal centres, in marked contrast to controls which received normal adult B cells.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002645:Chickens; D004912:Erythrocytes / Q000276:immunology; D007121:Immunocompetence; D007075:Immunoglobulin M / Q000096:biosynthesis*; D013154:Spleen / Q000166:cytology* / Q000276:immunology*
D007075:Immunoglobulin M