Temporal effects of infused corticosterone and aldosterone on plasma glucose levels in the American bullfrog (Rana catesbeiana).
The effects of a single infusion of corticosterone or aldosterone on plasma glucose levels were compared in the American bullfrog (Rana catesbeiana). The corticoids were administered, and serial blood samples were collected, via a cannula placed in the common iliac artery. Plasma glucose was estimated by the glucose oxidase method. Plasma glucose levels were essentially unchanged from the time-zero levels at 3 hr after the infusion of 1.0 mg/100 g body wt of corticosterone. The levels subsequently increased to maxima that were approximately 45% greater than the time-zero levels at 9 through 24 hr and then declined to approximately the initial levels by 48 hr after treatment. Infusion of 0.24 mg/100 g body wt of aldosterone did not significantly alter plasma glucose levels. The results suggest that elevated circulating corticosterone is not involved in the primary hyperglycemic response to a stress, but may function synergistically and sequentially with elevated circulating catecholamines in subsequent compensatory adjustments.
D000450:Aldosterone / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003345:Corticosterone / Q000097:blood / Q000494:pharmacology*; D005260:Female; D008297:Male; D011892:Rana catesbeiana / Q000097:blood*; D013312:Stress, Physiological / Q000097:blood; D013997:Time Factors
D001786:Blood Glucose; D000450:Aldosterone; D003345:Corticosterone