Ibuprofen and acetaminophen kinetics when taken concurrently.
We evaluated kinetics of ibuprofen and acetaminophen taken concurrently by 20 healthy adults in a randomized crossover design. Steady-state blood levels of ibuprofen and acetaminophen were measured by gas-liquid chromatography and HPLC. There were no significant differences in any of the ibuprofen serum concentrations, but there were differences in acetaminophen serum concentrations in 5 of 19 sampling times. When bioavailability and kinetic parameters for both drugs were compared, there were no significant differences. Our data demonstrate that steady-state kinetics of ibuprofen and acetaminophen are not changed when taken concurrently.
D000042:Absorption; D000082:Acetaminophen / Q000378:metabolism*; D000328:Adult; D001682:Biological Availability; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000378:metabolism*; D007700:Kinetics; D008297:Male
D000082:Acetaminophen; D007052:Ibuprofen