Antiulcer actions in rats of new synthetic polyisoprenoids.
The effects of 3-N,N-dimethylaminopropyl farnesyl acetate (DMFA), N'-geranylpiperazinyl farnesyl acetamide (GPFA) and N'-methylpiperazinyl geranylgeranyl acetamide (MPGA) were studied on gastric secretion, gastric bleeding and gastric mucosubstances in rats. DMFA lowered gastric juice and gastric bleeding, and GPFA increased gastric mucosubstances and decreased gastric bleeding. MPGA showed remarkable effects for all of these tests. Consequently it might be said that MPGA is a useful agent against both aggressive and resistant factors on gastric functions.
D000423:Alcian Blue; D000758:Anesthesia; D000818:Animals; D000897:Anti-Ulcer Agents; D004224:Diterpenes / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000378:metabolism; D006471:Gastrointestinal Hemorrhage / Q000517:prevention & control; D006595:Hexosamines / Q000378:metabolism; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012717:Sesquiterpenes / Q000494:pharmacology*; D013315:Stress, Psychological / Q000503:physiopathology
C040939:3-N,N-dimethylaminopropylfarnesyl acetate; D000897:Anti-Ulcer Agents; D004224:Diterpenes; D006595:Hexosamines; C040941:N'-geranylpiperazinylfarnesyl acetamide; C040942:N'-methylpiperazinylgeranylgeranyl acetamide; D012717:Sesquiterpenes; D000423:Alcian Blue