Calculation of recurrence risk in the case of ankylosing spondylitis taking into consideration the antigen HLA-B-27.
The authors have provided a new recurrence risk table of ankylosing spondylitis. The mathematical problem solved was to combine a continuous distribution for polygenic inheritance with a discrete one, HLA-B-27 antigen 'yes' or 'no'. Previously the highest probability of recurrence was 0.0785 in the case of an affected mother's son and it increased to 0.1416 when the B-27 antigen positive affected mother had a B-27 positive son.
D000293:Adolescent; D005260:Female; D006680:HLA Antigens / Q000032:analysis; D015796:HLA-B27 Antigen; D006801:Humans; D008297:Male; D008957:Models, Genetic; D012306:Risk; D013167:Spondylitis, Ankylosing / Q000235:genetics* / Q000276:immunology
D006680:HLA Antigens; D015796:HLA-B27 Antigen