title: The safety of fetoscopy: (I). Effect of umbilical vessel puncture on the fetal heart rate and cord histology.
abstract: The fetal heart rate (FHR) was continuously monitored during 42 umbilical vessel punctures performed at the placental insertion of the cord in 24 diagnostic fetoscopies in which pure fetal blood was obtained. In only one patient did a deceleration first appear during puncture and aspiration of fetal blood. In two patients decelerations preceded fetoscopy and in two others they began during the fetoscopy but before puncture of an umbilical vessel. In 19 patients, the FHR did not change at all during the procedure. Fetal haemorrhage after sampling was either absent or minimal. Six pregnancies were terminated because a positive diagnosis had been made and 18 healthy babies were born. Umbilical cords were examined after 7 terminations of pregnancy and after 6 deliveries. In the former group the puncture could just be seen with the naked eye and the needle track was demonstrated histologically in 6. No traces of the puncture or other abnormalities were found in the cords after delivery. Fetal blood sampling from umbilical cord vessels, particularly at the placental insertion of the cord, is the technique of choice since pure fetal blood can be obtained without increasing the risk of fetoscopy.
mesh_terms: D001800:Blood Specimen Collection; D005260:Female; D005312:Fetal Blood; D005318:Fetal Heart; D005332:Fetoscopy / Q000009:adverse effects*; D006339:Heart Rate; D006470:Hemorrhage / Q000473:pathology; D006801:Humans; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000009:adverse effects*; D014469:Umbilical Arteries / Q000473:pathology; D014470:Umbilical Cord / Q000473:pathology*; D014471:Umbilical Veins / Q000473:pathology