Effects of 1,25- and 24,25-dihydroxyvitamin D3 on bone formation in the cichlid teleost Sarotherodon mossambicus.
1,25-Dihydroxyvitamin D3 and 24,25-dihydroxyvitamin D3 have antagonistic effects on the acellular bone of the tilapia Sarotherodon mossambicus. 1,25-Dihydroxyvitamin D3 inhibits the activity of the lining osteoblasts. Prolonged administration leads to demineralization of the bone matrix. Injection of 24,25-dihydroxyvitamin D3 induces structural signs of greatly enhanced appositional bone growth within three days. No effects were observed on the mineral content of pre-existing bone. Both 1,25- and 24,25-dihydroxyvitamin D3 may have distinct, but different physiological functions in fish.
D015650:24,25-Dihydroxyvitamin D 3; D000818:Animals; D002117:Calcitriol / Q000494:pharmacology*; D004100:Dihydroxycholecalciferols / Q000494:pharmacology*; D005399:Fishes / Q000502:physiology*; D006900:Hydroxylation; D008297:Male; D010006:Osteoblasts / Q000187:drug effects / Q000648:ultrastructure; D010012:Osteogenesis / Q000187:drug effects*; D014807:Vitamin D / Q000378:metabolism
D004100:Dihydroxycholecalciferols; D014807:Vitamin D; D015650:24,25-Dihydroxyvitamin D 3; D002117:Calcitriol