Factor V deficiency and its reversal with gluten restriction. In a patient with celiac disease.
Hemorrhagic manifestations in patients with celiac disease are uncommon and, when present, are usually due to a deficiency of the vitamin K-dependent clotting factors. A patient with celiac disease was seen with a severe bleeding diathesis associated with deficiencies of factor V. The deficiencies of vitamin K-dependent clotting factors were rapidly reversed with parenteral administration of phytonadione. Factor V levels returned to normal levels only after gluten restriction.
D000328:Adult; D002446:Celiac Disease / Q000178:diet therapy*; D005166:Factor V Deficiency / Q000178:diet therapy*; D006801:Humans; D008297:Male; D010837:Vitamin K 1 / Q000627:therapeutic use
D010837:Vitamin K 1