Ascorbic acid and alkaline phosphatase activity.
Ascorbic acid is found strikingly to decrease the activity of bovine kidney alkaline phosphatase in vitro. The inhibition of alkaline phosphatase is a function of ascorbic acid concentration and is time and temperature dependent. The presence of the substrate protects the enzyme against the inhibitory action of the vitamin.
D000469:Alkaline Phosphatase / Q000037:antagonists & inhibitors*; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D002417:Cattle; D007668:Kidney / Q000201:enzymology*; D013696:Temperature; D013997:Time Factors
D000469:Alkaline Phosphatase; D001205:Ascorbic Acid