Observations on the responses of synovial lymphocytes to viral antigens in rheumatoid arthritis and Reiter's syndrome.
The responses of synovial lymphocytes to 12 microbiological antigens, including 8 viral antigens, were studied with the 3H-thymidine uptake procedure in 15 patients with rheumatoid arthritis (RA) and 4 patients with Reiter's syndrome. In 4 patients with rheumatoid factor (RF) negative RA, responses to the paramyxovirus antigens, parainfluenza and respiratory syncytial were marked, with lesser responses to adenovirus and mumps antigens. The synovial lymphocytes of 6 patients with RF titers of greater than or equal to 1:160 showed only minimal antigenic responses.
D000328:Adult; D000368:Aged; D000956:Antigens, Viral / Q000276:immunology*; D016918:Arthritis, Reactive / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013583:Synovial Membrane / Q000166:cytology / Q000276:immunology*; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D000956:Antigens, Viral; D014316:Tritium; D013936:Thymidine