Priapism--side-effect of prazosin in patients with renal failure.
Priapism developed during antihypertensive therapy with prazosin, 3-10 mg daily for 2-4 months, in two young men with severe renal failure. The cases are believed to be associated with alpha-adrenoceptor blocking and/or vasodilatory effects of the drug. Renal failure alone unlikely causes priapism, but may be an exposing factor for the episode.
D000328:Adult; D005921:Glomerulonephritis / Q000097:blood / Q000150:complications; D006801:Humans; D006977:Hypertension, Renal / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications*; D008297:Male; D011224:Prazosin / Q000009:adverse effects* / Q000097:blood; D011317:Priapism / Q000139:chemically induced*; D011799:Quinazolines / Q000009:adverse effects*
D011799:Quinazolines; D011224:Prazosin