HLA-DR positive T lymphocytes in blood and synovial fluid in rheumatoid arthritis.
HLA-DR expression was found on 6.7 +/- 0.7% of blood T lymphocytes from 34 patients with rheumatoid arthritis (RA) and 2.6 +/- 0.3% of T cells from normals. In synovial fluid (SF) of RA patients high percentages were found (56 +/- 3%, n = 18); the SF T lymphocytes showed an acid alpha-naphthyl acetate esterase pattern and cell morphology compatible with activated T lymphocytes. The helper function for pokeweed mitogen induced B cell differentiation was higher in blood T lymphocytes from RA patients than from normal controls; in SF T lymphocytes helper function could not be established. These differences between blood and SF T lymphocytes may represent differences in recirculating and homing properties of T cells in these compartments.
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D001799:Blood Sedimentation; D002097:C-Reactive Protein / Q000032:analysis; D005260:Female; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011043:Pokeweed Mitogens; D013582:Synovial Fluid / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D011043:Pokeweed Mitogens; D002097:C-Reactive Protein