Single-cell origin of bladder cancer induced by N-butyl-N-(4-hydroxybutyl) nitrosamine in mice with cellular mosaicism.
The single-cell origin of bladder cancer was established in mice with cellular mosaicism for phosphoglycerate kinase (PGK). Administration of N-butyl-N-(4-hydroxybutyl)nitrosamine in the drinking water resulted in development of large, solitary, infiltrating bladder carcinomas. On electrophoresis, PGK from all the cancer tissues examined gave only a single spot.
D000818:Animals; D002085:Butylhydroxybutylnitrosamine / Q000633:toxicity*; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced* / Q000201:enzymology; D004586:Electrophoresis; D051379:Mice / Q000235:genetics; D009030:Mosaicism; D009602:Nitrosamines / Q000633:toxicity*; D010735:Phosphoglycerate Kinase / Q000235:genetics / Q000302:isolation & purification; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000201:enzymology
D009602:Nitrosamines; D002085:Butylhydroxybutylnitrosamine; D010735:Phosphoglycerate Kinase