Transient currents carried by the uncoupler, carbonyl cyanide m-chlorophenylhydrazone.
The weak acid uncoupler, carbonyl cyanide m-chlorophenylhydrazone, carries protons across lipid membranes. As predicted by the carrier model, at low pH, the current changes immediately following a jump in applied potential and then remains constant. By contrast at high pH, the currents relax from an initial value to a lower value as the carrier anions redistribute in the membrane. These relaxations are slower than those seen with other lipid-soluble anions which presumably explains why they had not been detected previously.
D002258:Carbonyl Cyanide m-Chlorophenyl Hydrazone; D004553:Electric Conductivity; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008081:Liposomes; D008433:Mathematics; D008564:Membrane Potentials; D008954:Models, Biological; D009570:Nitriles
D008081:Liposomes; D009570:Nitriles; D002258:Carbonyl Cyanide m-Chlorophenyl Hydrazone