title: Azaprostaglandins. Synthesis and antiulcer activity of 11-deoxy-8-azaprostaglandin analogues.
abstract: We describe the synthesis and the antiulcer activity of new 11-deoxy-8-aza-PGE1 analogues (III a) and its C15-epimer (III b), (IV a) and its C15-epimer (IV b), featured by a triple bond in place of the C13-C14 trans double bond and a 16,16-dimethyl-17-oxabutyl omega-chain, respectively.
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D011459:Prostaglandins E, Synthetic / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013237:Stereoisomerism
chemical_list: D000897:Anti-Ulcer Agents; D011459:Prostaglandins E, Synthetic