Resistance to 4-hydroperoxycyclophosphamide of T cells involved in cell mediated antibacterial immunity.
4-Hydroperoxycyclophosphamide is a derivative of cyclophosphamide which in vitro is converted into an active metabolite of cyclophosphamide. This compound was used to define the relative susceptibilities of T cells involved in the immune response of mice to the intracellular pathogen, Listeria monocytogenes. L. monocytogenes-specific T cell proliferation and interleukin production in vitro, as well as adoptive protection and delayed-type hypersensitivity in vivo, all proved to be markedly resistant to the action of 4-hydroperoxy-cyclophosphamide, indicating a great homogeneity within the cellular immune response to intracellular pathogens.
D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D003520:Cyclophosphamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects; D007375:Interleukin-1 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D008088:Listeriosis / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013601:T-Lymphocytes / Q000276:immunology*
D000942:Antigens, Bacterial; D007375:Interleukin-1; D007376:Interleukin-2; D003520:Cyclophosphamide; C011272:perfosfamide