Head and neck manifestations of histiocytosis-X.
Histiocytosis-X is an uncommon disease, but is relevant to the otolaryngologist because patients with this malady present with, or ultimately develop, head and neck manifestations. Sixty-two patients with histologically confirmed histiocytosis-X have been examined at the Hospital for Sick Children in London since 1958. Most patients were under 2 years of age on initial examination and had either osseous or dermatologic disease involvement. Less commonly, otic or oral lesions were found. Histiocytosis-X is a systemic disease and must be treated accordingly. Isolated lesions may mimic common disease processes, therefore it is imperative that if a seemingly simple problem does not resolve with routine therapy, further patient evaluation be undertaken, If diagnosed, histiocytosis-X can generally be controlled with steroid therapy, or in more recalcitrant cases, by the addition of chemotherapy.
D000293:Adolescent; D001847:Bone Diseases / Q000150:complications / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D005148:Facial Dermatoses / Q000150:complications / Q000175:diagnosis*; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000150:complications / Q000175:diagnosis*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009059:Mouth Diseases / Q000150:complications / Q000175:diagnosis*; D009333:Neck; D012536:Scalp Dermatoses / Q000150:complications / Q000175:diagnosis*; D012886:Skull