[Allotransplantation of embryonic brain tissue into the brains of adult mammals during hypoxic hypoxia].
In order to simulate some manifestations of nervous system pathologies in humans and to examine the feasibility of normalizing the status of cerebral neurons in the case of their reversible dystrophy, cortical tissue from the brain hemispheres of rat embryos was transplanted into the parietal region of the brain in mature Wistar rats which had been previously exposed to hypoxic hypoxia. Hypoxia caused dystrophy, irreversible degeneration (shrinking and lysis) and death of large numbers of neurons in the cortex of the large hemispheres. The transplanted embryonic cerebral tissue developed into the normal nerve and glial cells in the brain of all the recipients. These cells established close morphological bonding with the adjacent nerve tissue of the hosts, which was accompanied by improvement in the state of neurons affected by reversible dystrophy.
D000818:Animals; D001921:Brain / Q000196:embryology; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D002534:Hypoxia, Brain / Q000473:pathology / Q000628:therapy*; D009417:Nerve Tissue / Q000637:transplantation*; D051381:Rats
Allotransplantatsiia émbrional'noĭ tkani mozga v golovnoĭ mozg vzroslykh mlekopitaiushchikh pri gipoksicheskoĭ gipoksii.