Acquired local resistance to burns: prevention of its acquisition by chlorpromazine.
Chlorpromazine administered to Sprague-Dawley rats 30 minutes prior to burning dramatically minimized burn oedema by a factor of 7 compared with controls. Reburning of the rats 72 hours later demonstrated acquisition of local (but not systemic) resistance to subsequent burning among the control animals, and prevention of the acquisition of local resistance by the previously treated chlorpromazine group. The pharmacological actions of chlorpromazine are discussed in relation to the above phenomena, and mechanisms for the results obtained are described.
D000818:Animals; D002056:Burns / Q000150:complications* / Q000175:diagnosis; D002746:Chlorpromazine / Q000627:therapeutic use*; D004487:Edema / Q000175:diagnosis / Q000209:etiology / Q000517:prevention & control*; D006614:Hindlimb / Q000293:injuries; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002746:Chlorpromazine