[Action of thymosin on the ultrastructure of the bone marrow in the rat].
A preparation isolated from thymus extract and possessing thymosin-like activity was studied for its influence on the ultrastructure of the rat bone marrow cells. A dose of the preparation adequate to therapeutic one (7 mg/kg) causes a transitory "irritation" (dystrophy and stimulation) in cellular elements of bone marrow. A supertherapeutic dose (70 mg/kg) has a definitely toxic effect on its cells and is characterized by an expressed tropism to the endothelium of sinusoids and capillaries.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000648:ultrastructure; D004305:Dose-Response Relationship, Drug; D008297:Male; D008854:Microscopy, Electron; D051381:Rats; D013947:Thymosin / Q000494:pharmacology*; D013951:Thymus Hormones / Q000494:pharmacology*; D013997:Time Factors
D013951:Thymus Hormones; D013947:Thymosin
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