Changes of the uterus epithelium proteins during the menstrual cycle and early pregnancy.
The changes in soluble cell proteins during stepped differentiation (from proliferative stage to secretory stage) of human uterus epithelium were studied. Polyacrylamide gel electrophoresis revealed 21 fractions of soluble endometrial proteins in the proliferative stage and 20 fractions in the secretory stage. During the first 12 weeks of pregnancy soluble decidual proteins consist of 13 fractions. In the process of stepped differentiation of the uterus epithelium a specific fraction that was absent in the original tissue was observed. Moreover two specific fractions, D1 (light) and D2 (heavy), were detected in soluble proteins of decidual tissue. According to data from SDS electrophoresis these two fractions had molecular weights of 52,000 and 150,000, respectively. A decrease in soluble protein fractions during stepped differentiation of human uterus epithelium seems to be connected with increased specialization of this tissue.
D003600:Cytosol / Q000378:metabolism*; D003656:Decidua / Q000648:ultrastructure; D004591:Electrophoresis, Polyacrylamide Gel; D004848:Epithelium / Q000648:ultrastructure; D005260:Female; D005498:Follicular Phase; D006801:Humans; D008183:Luteal Phase; D008598:Menstruation; D008970:Molecular Weight; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000032:analysis / Q000378:metabolism*; D011261:Pregnancy Trimester, First; D012269:Ribosomal Proteins / Q000032:analysis / Q000378:metabolism*; D012995:Solubility; D014599:Uterus / Q000648:ultrastructure*
D011257:Pregnancy Proteins; D012269:Ribosomal Proteins