Reserpine-induced depletion of corticoliberin (CRF)-like immunoreactivity in the zona externa of the rat median eminence.
An acute reserpine treatment has the same selective and marked depleting effect on corticoliberin-like immunoreactivity as on vasopressin-like immunoreactivity in the rat zona externa of the median eminence. Somatostatin and gonadoliberin immunoreactivities appear unmodified. Reserpine effect is blocked by pretreatment with monoamine oxidase inhibitors (pargyline or tranylcypromine). Present results support the notion of an inhibitory role of monoamines, particularly catecholamines, on the release of corticoliberin.
D000818:Animals; D002395:Catecholamines / Q000502:physiology; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D008297:Male; D008473:Median Eminence / Q000378:metabolism*; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D012701:Serotonin / Q000502:physiology; D014191:Tranylcypromine / Q000494:pharmacology
D002395:Catecholamines; D012701:Serotonin; D014191:Tranylcypromine; D012110:Reserpine; D003346:Corticotropin-Releasing Hormone; D010293:Pargyline