Role of endogenous prostaglandins in pregnancy termination by 15-methyl PGF2 alpha.
Thirty pregnant women with foetal death in utero received 15-methyl PGF2 alpha to terminate their pregnancies. Two groups (15 cases each) matched for age, gravidity and age of pregnancy were studied. One group received indomethacin suppositories before and during the PG induction while the second group received the prostaglandin analogue therapy only. The group which received the prostaglandin biosynthesis inhibitor showed a longer induction-termination interval, more PG ampoules were used and the number of failed cases was higher. Thus, the Release of Endogenous prostaglandins seems to play a complementary role in the therapeutic termination of pregnancy.
D000328:Adult; D002260:Carboprost / Q000627:therapeutic use*; D005260:Female; D005313:Fetal Death; D006801:Humans; D007751:Labor, Induced; D011247:Pregnancy; D011262:Pregnancy Trimester, Second / Q000187:drug effects; D011263:Pregnancy Trimester, Third / Q000187:drug effects; D011453:Prostaglandins / Q000502:physiology; D011461:Prostaglandins F, Synthetic / Q000627:therapeutic use*
D011453:Prostaglandins; D011461:Prostaglandins F, Synthetic; D002260:Carboprost