title: Effect of cycloheximide on skin and renal radiation tolerance in the rat.
abstract: The effect of cycloheximide (CHM) on skin and renal radiation tolerance in the rat has been studied. When administered 24 hr prior to a range of single radiation doses to the hind limbs, the drug protected against skin damage. When administered at intervals of 45 min to 100 hr prior to single-dose irradiation of the kidneys, no protection against renal injury, as manifested by blood pressure, urine creatinine level, and lethality, was observed. CHM-induced alteration in the cell cycle may confer radioprotection to a rapidly proliferating cell renewal system such as the skin and exert no radioprotective action in slowly proliferative tissue such as kidney.
mesh_terms: D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D007668:Kidney / Q000187:drug effects* / Q000528:radiation effects; D008297:Male; D011836:Radiation Tolerance; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects* / Q000528:radiation effects; D013997:Time Factors
chemical_list: D011837:Radiation-Protective Agents; D003513:Cycloheximide