Mathematical studies of complement activation.
Kinetic studies of complement activation were followed by hemolytic assay. Mathematical analysis shows that the curve is composed of two exponents: the first one, which occurs during a short span of time, represents the classical pathway, the second the alternative pathway. We were therefore able to foretell the respective participation of each activator used: inulin, zymosan, and aggregated immunoglobulins.
D003167:Complement Activation / Q000187:drug effects; D003170:Complement Pathway, Alternative; D003171:Complement Pathway, Classical; D006801:Humans; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007444:Inulin / Q000494:pharmacology; D007700:Kinetics; D008433:Mathematics; D015054:Zymosan / Q000494:pharmacology
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007444:Inulin; D015054:Zymosan