H-Y antigen in human X-autosome translocations.
The distal segment of the X chromosome short arm (Xp223) escapes X-inactivation in the normal female. This was shown by the activity of three genes assigned to this segment, those for Xg, STS, and H-YB. In contrast, in cases with non-random X-inactivation due to structural aberration of one X chromosome, the genes for Xg and STS may undergo inactivation. In this article, it is shown that in X-autosome translocation, the H-YB gene which modifies the activity of H-Y antigen, may be inactivated as well. Evidence is presented that in these cases, expression of all three genes on Xp223 is concordant.
D000818:Animals; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D004303:Dosage Compensation, Genetic; D005260:Female; D005347:Fibroblasts / Q000276:immunology; D005786:Gene Expression Regulation; D006182:H-Y Antigen / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007106:Immune Sera; D007621:Karyotyping; D010641:Phenotype; D051381:Rats; D011917:Rats, Inbred Lew; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D014178:Translocation, Genetic; D014960:X Chromosome
D006182:H-Y Antigen; D007106:Immune Sera