Tumors producing chronic hyperprolactinemia do not alter [3H]spiperone binding and dopamine turnover in the corpus striatum of the female rat.
We studied the effect of prolactin on the dopamine (DA) receptor density and DA turnover of the rat corpus striatum. Chronic hyperprolactinemia was produced in female rats by implanting prolactin-secreting pituitary tumors. Even in the presence of circulating prolactin concentrations that were two to three orders of magnitude greater than normal, there was no apparent change in the affinity or maximal site numbers of DA receptors in the corpus striatum. In concert with this observation, prolactin also failed to alter DA turnover in the corpus striatum as reflected in the DA/DOPAC ratio. Under the conditions of our experiments, there was no evidence to confirm previous observations of increased density of DA receptors of the corpus striatum in the hyperprolactinemic state.
D000818:Animals; D002090:Butyrophenones / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D010911:Pituitary Neoplasms / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011954:Receptors, Dopamine / Q000032:analysis / Q000187:drug effects; D013134:Spiperone / Q000378:metabolism*
D002090:Butyrophenones; D011954:Receptors, Dopamine; D013134:Spiperone; D011388:Prolactin; D004298:Dopamine