[Effect of prodigiozan, levamisole and methyluracil on delayed hypersensitivity against a background of immunosuppressor use].
Immunostimulants, such as prodigiosan, levamisol and methyluracil, as well as their combinations with imuran, prednisolone or cyclophosphamide were studied for their effect on the delayed type hypersensitivity (DTH) induced by dinitrofluorobenzene alcohol solutions applied in challenge doses to the floor of the auricle of mice. It was shown that the immunostimulants did not affect the DTH in intact mice. In mice treated with imuran the DTH was significantly increased only by prodigiosan. Prednisolone used for a prolonged period before and after the sensitization and cyclophosphamide administered 24 hours before the sensitization increased the DTH. According to the literature data it was connected with T-suppressor inhibition. With the use of cyclophosphamide it was also connected with B-suppressor inhibition. Under such conditions the DTH was decreased to the control level by prodigiosan after the use of prednisolone or by levamisol after the use of cyclophosphamide. This was probably associated with increasing of the suppressor effect of the macrophages and activation of the T-suppressor effect by levamisol. Methyluracil had no effect on the DTH.
D000818:Animals; D001379:Azathioprine / Q000276:immunology; D003520:Cyclophosphamide / Q000276:immunology; D004342:Drug Hypersensitivity / Q000209:etiology*; D004347:Drug Interactions; D005260:Female; D006968:Hypersensitivity, Delayed / Q000209:etiology*; D007166:Immunosuppressive Agents / Q000276:immunology*; D007978:Levamisole / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D011239:Prednisolone / Q000276:immunology; D011354:Prodigiozan / Q000276:immunology*; D014498:Uracil / Q000031:analogs & derivatives* / Q000276:immunology
D007166:Immunosuppressive Agents; D011135:Polysaccharides, Bacterial; D007978:Levamisole; D014498:Uracil; C008378:6-methyluracil; D003520:Cyclophosphamide; D011354:Prodigiozan; D011239:Prednisolone; D001379:Azathioprine
Vliianie prodigiozana, levamizola i metiluratsila na giperchuvstvitel'nost' zamedlennogo tipa na fone primeneniia immunosupressorov.