Acute oligoarthritis associated with Clostridium difficile pseudomembranous colitis.
The abrupt onset of a sterile inflammatory oligoarthritis developed in a patient with active Clostridium difficile pseudomembranous colitis. The arthritis affected a hip and a knee. Leukocyte counts of synovial fluid obtained from the patient's left hip and knee were elevated. He was haplotyped as HLA-B27 antigen-positive. The colitis and arthritis promptly abated after treatment with oral vancomycin hydrochloride. Three other cases of arthritis associated with antibiotic-induced colitis were reviewed. It seems as if treatment of the colitis leads to resolution of the arthritis.
D000328:Adult; D003015:Clostridium Infections / Q000150:complications* / Q000188:drug therapy; D004761:Enterocolitis, Pseudomembranous / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006680:HLA Antigens / Q000302:isolation & purification; D015796:HLA-B27 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000209:etiology* / Q000503:physiopathology; D014640:Vancomycin / Q000627:therapeutic use*
D006680:HLA Antigens; D015796:HLA-B27 Antigen; D014640:Vancomycin