Stimulation of plasminogen activator in osteoblast-like cells by bone-resorbing hormones.
Hormonal control of plasminogen activator (PA) was studied in clonal rat osteogenic sarcoma cells which are phenotypically osteoblast, and in osteoblast-rich rat bone cell cultures. The bone-resorbing hormones (parathyroid hormone, prostaglandin E2, epidermal growth factor and 1,25-dihydroxyvitamin D3) stimulated PA activity in both cell types. The relative efficacies of vitamin D metabolites and of prostanoids reflect their relative potencies as stimulators of bone resorption.
D000818:Animals; D001862:Bone Resorption; D002117:Calcitriol / Q000494:pharmacology; D002460:Cell Line; D002999:Clone Cells; D015232:Dinoprostone; D004815:Epidermal Growth Factor / Q000494:pharmacology; D010006:Osteoblasts / Q000378:metabolism*; D012516:Osteosarcoma; D010281:Parathyroid Hormone / Q000494:pharmacology; D010960:Plasminogen Activators / Q000502:physiology*; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D012886:Skull
D010281:Parathyroid Hormone; D011458:Prostaglandins E; D004815:Epidermal Growth Factor; D010960:Plasminogen Activators; D002117:Calcitriol; D015232:Dinoprostone