title: [Results of an experiment on chemoprophylaxis of malaria using mefloquine in Cambodia (Cambodia-Thai border region)].
abstract: 39 members of a medical team working in an area near the Cambodia-Thaï border were given an individual antimalaria chemoprophylaxis by Mefloquine (2 tablets--500 mg--every other week), carried on for 2 months after return. Two falciparum accesses were reported after the return, and in one of them, there was also a failure of the Mefloquine treatment (1,5 g in 16 hours). This access was successfully treated by Naphtyridine. The results proved that Mefloquine is now the best individual chemoprophylaxis in this area of South East Asia where, from 1979 to 1981, the other prophylaxis failed (chloroquine, pyrimethamine + sulphonamide or sulfone, quinine); it was also discovered that some strains of P. falciparum were resistant to Mefloquine.
mesh_terms: D000328:Adult; D000962:Antimalarials / Q000627:therapeutic use*; D002160:Cambodia; D005260:Female; D006801:Humans; D008288:Malaria / Q000188:drug therapy / Q000517:prevention & control*; D008297:Male; D015767:Mefloquine; D008875:Middle Aged; D011804:Quinolines / Q000009:adverse effects / Q000627:therapeutic use*; D013785:Thailand
chemical_list: D000962:Antimalarials; D011804:Quinolines; D015767:Mefloquine
vernacular_title: Bilan d'une expérience de chimioprophylaxie du paludisme par la méfloquine au Cambodge (région frontalière Khmero-Thaïlandaise).