Progressive hemifacial atrophy (Parry-Romberg syndrome) report with review of genetics and nosology.
We describe a boy with mild hemifacial atrophy (Parry-Romberg syndrome); he had localized scleroderma on a leg and his trunk, and antinuclear antibodies in his serum. These findings support suggestions that this disorder could be a variant of localized scleroderma rather than a developmental anomaly or dysplasia. A review of the literature does not support assertions of autosomal dominant inheritance of the condition.
D000293:Adolescent; D000974:Antibodies, Antinuclear / Q000032:analysis*; D005150:Facial Hemiatrophy / Q000145:classification / Q000235:genetics*; D005799:Genes, Dominant; D014644:Genetic Variation; D006801:Humans; D008297:Male; D012594:Scleroderma, Localized / Q000145:classification / Q000235:genetics*; D013577:Syndrome; D009626:Terminology as Topic
D000974:Antibodies, Antinuclear