Effect of biogenic amines reuptake inhibition on ethanol induced hypothermia.
The mechanism of ethanol induced hypothermia (EIH) was examined by the use of chemically related compounds which inhibit 5-hydroxytryptamine (5-HT) or norepinephrine (NE) reuptake. Desipramine, a tricyclic antidepressant drug (TCA) and NE reuptake inhibitor partially antagonizes EIH. However, Nisoxetine (NE reuptake inhibitor but not TCA) did not abolish EIH. Chlorimipramine, a TCA compound and 5-HT reuptake inhibitor abolishes EIH. Meanwhile, fluoxetine (5-HT reuptake inhibitor, but not TCA) potentiated ethanol induced hypothermia. It was concluded that the antagonism of EIH is probably related to the antidepressant effect of TCA compounds.
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D002997:Clomipramine / Q000494:pharmacology; D003891:Desipramine / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology*; D007035:Hypothermia / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D001679:Biogenic Amines; D000431:Ethanol; D002997:Clomipramine; D003891:Desipramine