Effects of contrast media on pulmonary hemodynamics: comparison of ionic and non-ionic agents.
Hemodynamic effects of pulmonary arterial injections of ionic (sodium methylglucamine diatrizoate) and non-ionic contrast media (iohexol) were compared in 9 anesthetized dogs which were maintained with an open thorax in a resting control state. Both were found to increase pulmonary arterial pressure and cardiac output. In addition, both resulted in decreased systemic vascular resistance, though the effect was significantly less with the non-ionic agent. Aortic pressure did not change with the non-ionic agent but fell drastically with the ionic agent. Contrary to prevailing beliefs, the predominant response of the pulmonary circulation to contrast media was a fall rather than a rise in pulmonary vascular resistance.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003287:Contrast Media / Q000494:pharmacology*; D003974:Diatrizoate Meglumine / Q000494:pharmacology; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects*; D007472:Iohexol; D009200:Myocardial Contraction / Q000187:drug effects; D011651:Pulmonary Artery / Q000502:physiology; D011652:Pulmonary Circulation / Q000187:drug effects*; D014283:Triiodobenzoic Acids / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects
D003287:Contrast Media; D014283:Triiodobenzoic Acids; D003974:Diatrizoate Meglumine; D007472:Iohexol