title: Behavioral changes in aging Aplysia: a model system for studying the cellular basis of age-impaired learning, memory, and arousal.
abstract: The marine mollusc Aplysia californica was used to examine the effects of age on simple forms of learning, memory, and arousal. We have found that aging impairs the long-term retention of habituation and prevents the acquisition of sensitization in the siphon withdrawal reflex. In addition, aging reduces arousal as evident in the heart rate component of the response to food stimuli. Our results are similar to the age-dependent alterations in the capacity for behavioral plasticity that have been reported in a variety of vertebrates, including man. These similarities suggest that the mechanisms underlying the effects of age on behavior and its modification may share common features across phyla and therefore might be studied to advantage in Aplysia whose central nervous system is especially accessible to cell biological approaches.
mesh_terms: D000375:Aging; D000818:Animals; D001048:Aplysia / Q000502:physiology*; D001143:Arousal / Q000502:physiology*; D006185:Habituation, Psychophysiologic / Q000502:physiology; D006339:Heart Rate; D007858:Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology; D012018:Reflex