title: Histiocytosis X in two adults. Treatment with topical mechlorethamine.
abstract: Two adult patients with skin lesions typical of histiocytosis X were treated topically with mechlorethamine hydrochloride. In the patient whose disease was limited to the skin, a sustained remission was induced, but in the patient with extensive systemic disease, cutaneous remission lasted only six weeks.
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D007085:Ilium / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage* / Q000627:therapeutic use; D010014:Osteolysis / Q000000981:diagnostic imaging; D013902:Radiography, Thoracic; D012871:Skin Diseases / Q000188:drug therapy* / Q000473:pathology
chemical_list: D008466:Mechlorethamine