Control of the hormonal secretions of quail embryo gonads (normal and DES-treated): in vitro effects of testosterone and of hCG.
In vitro effects of factors such as testosterone or hCG on steroidogenesis by 12-day quail embryo gonads have been investigated by radioimmunoassays. The purpose was to compare the hormonal potentialities (estradiol, estrone, and dihydrotestosterone; E1, E2, DHT) of normal and diethylstilbestrol-treated gonads. The results demonstrate that the reduced steroid production by the treated ovaries does not result from their inability to respond to both factors, but reflects their weakened stimulation in vivo at the time of explantation. On the other hand, the secreting abilities of the DES-treated male gonads do not greatly differ from those of normal testes; even in the presence of favorable factors, and despite their feminization, the ovotestes are effectively unable to produce significative amounts of estradiol. These results are compared with others obtained elsewhere in quail and in chick embryos.
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D004054:Diethylstilbestrol / Q000494:pharmacology; D013196:Dihydrotestosterone / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D004970:Estrone / Q000378:metabolism; D005260:Female; D012739:Gonadal Steroid Hormones / Q000378:metabolism*; D008297:Male; D010053:Ovary / Q000187:drug effects / Q000196:embryology* / Q000378:metabolism; D011784:Quail / Q000196:embryology*; D013737:Testis / Q000187:drug effects / Q000196:embryology* / Q000378:metabolism; D013739:Testosterone / Q000494:pharmacology*
D006063:Chorionic Gonadotropin; D012739:Gonadal Steroid Hormones; D013196:Dihydrotestosterone; D004970:Estrone; D013739:Testosterone; D004958:Estradiol; D004054:Diethylstilbestrol