[Effect of neonatal androgenization on uterine sarcomagenesis induced by 1,2-dimethylhydrazine in female CBA mice].
A single injection of testosterone propionate to newborn female CBA mice provoked earlier puberty and formation of permanent estrous in the majority of animals. This led to an abrupt reduction of the latent period and the increased incidence of 1,2-dimethylhydrazine-induced uterine sarcomas (90 versus 9% upon DMH injection to intact mice).
D019813:1,2-Dimethylhydrazine; D000728:Androgens / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D002273:Carcinogens; D004127:Dimethylhydrazines; D005260:Female; D008763:Methylhydrazines; D051379:Mice; D008808:Mice, Inbred CBA; D012513:Sarcoma, Experimental / Q000139:chemically induced*; D013739:Testosterone / Q000008:administration & dosage; D014594:Uterine Neoplasms / Q000139:chemically induced*
D000728:Androgens; D002273:Carcinogens; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D013739:Testosterone; D019813:1,2-Dimethylhydrazine
Vliianie neonatal'noĭ androgenizatsii na sarkomogenez matki, indutsirovannyĭ 1,2-dimetilgidrazinom u mysheĭ-samok linii CBA.