Epidermal growth factor stimulates growth hormone secretion from superfused rat adenohypophyseal fragments.
Epidermal growth factor (EGF) stimulated GH secretion from superfused rat adenohypophyseal fragments in a dose-related manner (8-50 ng/ml). Secretion of PRL or TSH was not affected by EGF at concentrations up to 50 ng/ml. These results indicate that EGF may be a specific secretagogue for GH in rats.
D000818:Animals; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005260:Female; D013006:Growth Hormone / Q000378:metabolism*; D066298:In Vitro Techniques; D010477:Perfusion / Q000379:methods; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013972:Thyrotropin / Q000378:metabolism; D013997:Time Factors
D004815:Epidermal Growth Factor; D011388:Prolactin; D013972:Thyrotropin; D013006:Growth Hormone