title: Invariant relation between total acid secretion and secretagogue exposure: secretory dynamics in bullfrog.
abstract: Using a continuous recording of acid secretion in frog gastric mucosa by pH-stat interfaced with a microcomputer, the pattern of secretion rate was studied under variable concentrations and durations of stimulation by histamine and forskolin. This tissue can respond with only a limited range of secretory rates. Larger concentrations and/or longer durations of stimulation may result in a secretion rate pattern prolonged far beyond the duration of stimulation. Although for the concentration-response curve the steady-state or peak acid secretion varies with the duration of stimulation, total acid secreted as a function of exposure to stimulator (time integral of the stimulatory pattern) is independent of the stimulatory pattern.
mesh_terms: D000818:Animals; D005576:Colforsin; D004224:Diterpenes / Q000494:pharmacology; D005750:Gastric Juice / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D011892:Rana catesbeiana / Q000502:physiology*; D012636:Secretory Rate / Q000187:drug effects
chemical_list: D004224:Diterpenes; D005576:Colforsin; D006632:Histamine