Cyclical antiidiotypic response to anti-hormone antibodies due to neutralization by autologous anti-antiidiotype antibodies that bind hormone.
Antiidiotype antibodies were raised against anti-catecholamine ligand antibodies. The antiidiotype response was shown to be cyclical and to correspond to the production of antibodies that could bind to catecholamine beta-adrenergic receptors and stimulate adenylate cyclase. Disappearance of these antibodies from the serum could be correlated with the appearance of a catecholamine ligand-binding activity corresponding to the synthesis of autologous anti-antiidiotype antibodies directed against the induced antiidiotypic molecules. Comparison of the injected versus the induced anti-ligand antibodies reveals striking differences in affinities but similarities in the ability to bind to the antiidiotype antibodies and to the ligand-containing affinity gel. The results support the existence of a functional network of idiotype antiidiotype interactions involving external as well as internal antigens, antibodies, and possibly other types of molecules involved in recognition phenomena, such as hormone receptors.
D000526:Alprenolol / Q000276:immunology / Q000378:metabolism; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis / Q000096:biosynthesis*; D000915:Antibody Affinity; D001666:Binding Sites, Antibody; D001667:Binding, Competitive; D002395:Catecholamines / Q000276:immunology* / Q000378:metabolism; D004306:Dose-Response Relationship, Immunologic; D007074:Immunoglobulin G / Q000032:analysis; D007130:Immunoglobulin Idiotypes / Q000096:biosynthesis* / Q000235:genetics / Q000276:immunology; D009500:Neutralization Tests; D011817:Rabbits; D013997:Time Factors
D000888:Antibodies, Anti-Idiotypic; D002395:Catecholamines; D007074:Immunoglobulin G; D007130:Immunoglobulin Idiotypes; D000526:Alprenolol