The effect of androgens on DNA synthesis by fetal hemopoietic stromal cells.
Fibroblast-like stromal cells from mid-term fetal bovine liver and bone marrow were grown in liquid culture. The low proliferative activity of these cells is highly increased by serum, after entering a quiescent stage by a serum step-down stimulus. In such condition, androgens stimulate DNA synthesis in stromal cells derived from liver. An inhibitory effect, however, was observed in stromal cells from fetal bone marrow.
D000728:Androgens / Q000494:pharmacology*; D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D001854:Bone Marrow Cells; D002417:Cattle; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D005333:Fetus / Q000378:metabolism*; D005347:Fibroblasts / Q000378:metabolism; D006412:Hematopoietic Stem Cells / Q000378:metabolism*; D008099:Liver / Q000166:cytology / Q000378:metabolism
D000728:Androgens; D004247:DNA