Prevention of peritoneal adhesion formation by fibrin sealant. An experimental study in rats.
The preventive effect of rat and human fibrin sealing on intra-abdominal adhesion formation was investigated in 40 rats. Intraperitoneal adhesion formation was induced by excision of 1 X 3 cm of the peritoneal parietalmuscular layer, subsequently closed by interrupted 3-0 silk sutures. A total of 80 defects were allocated to one of four treatments: 1) the defect was covered with human fibrin sealant with the aid of a syringe. 2) the defect was covered with rat fibrin sealant with the aid of a syringe. 3) the defect was covered with human fibrin sealant with the aid of a spray. 4) the defect was not covered (control group). Assessment of the adhesion formation one week postoperatively showed that the median length of adhesions in defects covered with fibrin sealant applied by a syringe (10.5 mm) or by spray (14 mm) was less than that of the control group (25 mm) to a significantly high degree (P less than 0.001). It is concluded that fibrin sealant prevents intraperitoneal adhesion formation in the present rat model.
D000818:Animals; D000933:Antifibrinolytic Agents / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D005176:Factor XIII / Q000627:therapeutic use*; D005260:Female; D005337:Fibrin / Q000627:therapeutic use*; D015718:Fibrin Tissue Adhesive; D005340:Fibrinogen / Q000627:therapeutic use*; D005353:Fibronectins / Q000627:therapeutic use*; D006801:Humans; D010530:Peritoneal Dialysis; D010532:Peritoneal Diseases / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains; D013917:Thrombin / Q000627:therapeutic use*; D000267:Tissue Adhesions / Q000517:prevention & control; D014014:Tissue Adhesives / Q000627:therapeutic use*
D000933:Antifibrinolytic Agents; D004338:Drug Combinations; D015718:Fibrin Tissue Adhesive; D005353:Fibronectins; D014014:Tissue Adhesives; D005337:Fibrin; D005340:Fibrinogen; D005176:Factor XIII; D013917:Thrombin