Autoimmunity in a patient with 47,XXX karyotype.
Premature ovarian failure in women with a 47,XXX karyotype have been described, but an explanation for this gonadal disorder has not been forthcoming. The present case identifies a 47 triple X woman with premature ovarian failure associated with an autoimmune disorder. A possible association between the 47,XXX karyotype, autoimmune disorders, and premature ovarian failure is proposed.
D000328:Adult; D001327:Autoimmune Diseases / Q000150:complications*; D005260:Female; D006801:Humans; D007621:Karyotyping; D010049:Ovarian Diseases / Q000150:complications; D011247:Pregnancy; D012729:Sex Chromosome Aberrations / Q000150:complications*; D014314:Trisomy; D014960:X Chromosome