The effect of a 5-HT antagonist, ketanserin, on blood pressure, the renin-angiotensin system and sympathoadrenal function in normal man.
The role of endogenous 5-hydroxytryptamine (5-HT) in the control of blood pressure, the renin-angiotensin system and sympatho-adrenal function was investigated in normal man. Ketanserin (a specific 5-HT2 antagonist) administered intravenously caused a small decrease in blood pressure in salt-depleted recumbent subjects. A more marked postural fall in pressure occurred in both sodium-depleted and repleted normal subjects. Plasma active renin concentration and angiotensin II increased after administration of ketanserin, but plasma aldosterone, cortisol and noradrenaline were unchanged. 5-HT may be important in the control of blood pressure in man and specific 5-HT2 receptor antagonists could be a useful new class of antihypertensive agents.
D000311:Adrenal Glands / Q000187:drug effects*; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D004032:Diet; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007650:Ketanserin; D008297:Male; D010656:Phenylephrine; D010880:Piperidines / Q000494:pharmacology*; D011187:Posture; D012084:Renin-Angiotensin System / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013564:Sympathetic Nervous System / Q000187:drug effects*; D013997:Time Factors
D010880:Piperidines; D012702:Serotonin Antagonists; D010656:Phenylephrine; D007650:Ketanserin