Isolation and transmission of human retrovirus (human t-cell leukemia virus).
Nine new isolates of human T-cell leukemia-lymphoma virus (HTLV) were obtained from cells of seven patients with malignancies of mature T cells and from two clinically normal relatives of a T-cell leukemia patient. These people were from the United States, Israel, the West Indies, and Japan. The virus was detected in the fresh T cells and was isolated from the established T-cell lines. Each isolate is closely related to the first HTLV isolate, and all the new HTLV isolates were transmitted into normal human T cells obtained from the umbilical cord blood of newborns.
D002460:Cell Line; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D007938:Leukemia / Q000382:microbiology*; D008297:Male; D012190:Retroviridae / Q000254:growth & development / Q000302:isolation & purification*; D013601:T-Lymphocytes / Q000382:microbiology*