[Effect of niflumic acid on the non-acid transport of chlorides in the gastric mucosa of amphibians].
The in vivo gastric mucosa actively transport Cl- (serosa to mucosa) and it has been shown that the e.m.f. generated by the epithelium, as well as the short circuit current are both manifestations of the same phenomenon: the Cl- movement. Also, it has been postulated the presence of a Cl- - HCO-3 exchange in the gastric epithelium probably located on different cell types. The addition of niflumic acid (10(-4) M in the serosal solution) resulted in a decline towards zero of both transepithelial p.d. and Isc. The mechanism of the niflumic acid action is postulated to be a blockage of the Cl- - HCO-3 exchange, similarly to the SITS action mechanism.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002712:Chlorides / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D009539:Nicotinic Acids / Q000494:pharmacology*; D009544:Niflumic Acid / Q000494:pharmacology*; D011893:Rana esculenta
D002712:Chlorides; D009539:Nicotinic Acids; D009544:Niflumic Acid
Effetto dell'acido niflumico sul trasporto non-acido di Cl- in mucosa gastrica di anfibi.