Antigen-specific T-cell lines in DNCB-contact sensitivity in guinea pigs.
Expanded DNP-specific guinea pig T cells exhibit enhanced in vitro and in vivo activity as demonstrated by DNA synthesis and systemic adoptive transfer of contact sensitivity. Moreover, expanded lymphocytes are capable of accomplishing local passive transfer of contact sensitivity and producing interleukin 2, vascular permeability-increasing and macrophage migration-inhibiting factors. Expansion of hapten-specific lymphocytes offers a suitable model for studying eliciting mechanism of allergic contact dermatitis in humans.
D000818:Animals; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D003877:Dermatitis, Contact / Q000276:immunology / Q000503:physiopathology*; D004137:Dinitrochlorobenzene; D005260:Female; D006168:Guinea Pigs; D006241:Haptens / Q000276:immunology; D007116:Immunization, Passive; D007376:Interleukin-2 / Q000096:biosynthesis; D008297:Male; D013601:T-Lymphocytes / Q000378:metabolism / Q000502:physiology*
D004137:Dinitrochlorobenzene; D006241:Haptens; D007376:Interleukin-2; D004247:DNA