[Effect of long-term administration of T-activin on the structure of the thymus].
Morphometry was used to study the effect of T-activin on the morphology of the thymus of (CBA X C57BL) F1 mice given 10, 15 and 20 injections of T-activin (1.0 micrograms i.p.). T-activin did not cause any pathological alterations in the thymus. Ten injections of T-activin activated the proliferation and migration of thymocytes from the thymus. Fifteen injections of T-activin eventuated in an increased surge of thymocyte migration from the thymus, whereas 20 injections gave rise to a new surge of proliferation and preparation or beginning of thymocyte migration from the thymus. It is concluded that prolonged injection of T-activin does not disturb the fluctuation pattern of thymus functioning but activates the transformation and migration of thymocytes.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010455:Peptides; D013601:T-Lymphocytes / Q000187:drug effects; D013949:Thymus Extracts / Q000494:pharmacology*; D013950:Thymus Gland / Q000187:drug effects*; D013997:Time Factors
D010455:Peptides; D013949:Thymus Extracts; C036191:T-activin
Vliianie dlitel'nogo vvedeniia T-aktivina na strukturu timusa.