The MO/NK cell: an inducer of HLA-independent graft-versus-host disease?
We have described the MO/NK cell assay, a model for detecting non-HLA allodisparities between donor and host cells in co-culture prior to BMT. Generation of CFUc-inhibitory activity in MO/NK cells in this system is predictive of GvHD. We have also described a modified 3-step model in which allosensitized donor MO/NK cells induce autologous T cells to develop CFUc-inhibitory activity. This model may reflect the mechanism of induction of alloreactive donor-type T cells in HLA-matched BMT recipients who develop GvHD. The MO/NK cell assay could become a useful tool for improved donor:host matching or for identifying high-risk BMT recipients who might benefit from early institution of vigorous anti-GvHD prophylaxis. The 3-step model could provide a useful tool for studying cellular interactions leading to GvHD and for assessing effects of anti-GvHD agents on individual cellular components of GvH reactions.
D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D006086:Graft vs Host Disease / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D009000:Monocytes / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D006680:HLA Antigens