[Effect of benzonal on the resistance of animals to the action of organophosphorus and carbamic compounds].
The inductor of microsomal enzymes, benzonal (20 mg/kg) produces an overt preventive and treatment-preventive action in acute and subacute poisoning with organophosphorus (DDVP, parathion, TEPP, chlorophos) and carbamic (pirimor, sevin) compounds. As regards the efficacy benzonal is not inferior to phenobarbital (14 mg/kg). Pretreatment with benzonal averts the development of the neuromuscular blockade and normalizes spontaneous activity of the myoneural synapse of rats and cats poisoned with pirimor and parathion.
D000818:Animals; D001463:Barbiturates / Q000627:therapeutic use*; D002219:Carbamates; D002415:Cats; D007306:Insecticides / Q000506:poisoning*; D051379:Mice; D009943:Organophosphorus Compounds; D010634:Phenobarbital / Q000627:therapeutic use; D051381:Rats
D001463:Barbiturates; D002219:Carbamates; D007306:Insecticides; D009943:Organophosphorus Compounds; C002915:benzobarbital; D010634:Phenobarbital
Vliianie benzonala na ustoĭchivost' zhivotnykh k deĭstviiu fosfororganicheskikh i karbaminovykh soedineniĭ.