Malignant myositis ossificans: occult gastric carcinoma presenting as an acute rheumatic disorder.
A patient developed ossifying skeletal muscle metastases from a primary gastric mucin-producing adenocarcinoma. The unusual nature of skeletal muscle metastases and the inflammatory-like syndrome associated with heterotopic ossification is reviewed. It is suggested that this case of 'neoplasm-induced post-traumatic myositis ossificans' may be caused by the interaction of local haemorrhage and thrombosis, mucin-producing tumour implants, and the presence of large quantities of gamma-carboxyglutamic acid, an amino acid associated with the calcification of bone matrix formation.
D015055:1-Carboxyglutamic Acid / Q000378:metabolism; D000230:Adenocarcinoma / Q000556:secondary*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000293:injuries; D009135:Muscular Diseases / Q000150:complications*; D009221:Myositis Ossificans / Q000209:etiology* / Q000378:metabolism; D012216:Rheumatic Diseases / Q000209:etiology*; D013274:Stomach Neoplasms
D015055:1-Carboxyglutamic Acid