[Evaluation of T- and B-cell immunity of regional lymph nodes in patients with skin melanoma and prognosis of the disease].
Immune response of regional lymph nodes was studied in 30 skin melanoma patients. T-lymphocyte count in metastatic lymph nodes was lower than in those without metastases. T-lymphocyte proliferation in response to PHA was inhibited 3-fold and the level of surface immunoglobulin-bearing B-lymphocytes was approximately 1.6 times lower in the involved node group. Cytological examination of the involved nodes detected a decrease in the counts of lymphocytes and reticular cells. This further confirms that metastatic involvement of lymph nodes is associated with a low immunologic activity, thus suggesting an unfavorable prognosis.
D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000276:immunology*; D008207:Lymphatic Metastasis; D008213:Lymphocyte Activation; D008545:Melanoma / Q000276:immunology*; D008875:Middle Aged; D011379:Prognosis; D012397:Rosette Formation; D012878:Skin Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
Otsenka T- i B-sistemy immuniteta regionarnykh limfaticheskikh uzlov u bol'nykh melanomoĭ kozhi i prognoz zabolevaniia.