title: Preliminary studies on the venom of the colubrid snake Rhabdophis subminatus (red-necked keelback).
abstract: Following the bite by Rhabdophis subminatus, preliminary studies were instituted on its venom to determine the mechanism of the clinical poisoning. A method for milking these snakes is presented. The i.v. LD50 in mice was 1.29 mg/kg. Three peaks were obtained on Sephadex G-100 and although none were lethal by themselves, a combination of two of the peaks produced immediate death in mice. The venom had no phosphodiesterase, fibrinolytic or thrombin-like activities, but it did have some phospholipase activity. Further biochemical and pharmacological studies are in progress.
mesh_terms: D000328:Adult; D000818:Animals; D004798:Enzymes / Q000032:analysis; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008970:Molecular Weight; D012909:Snake Bites / Q000503:physiopathology; D012910:Snake Venoms / Q000032:analysis* / Q000633:toxicity
chemical_list: D004798:Enzymes; D012910:Snake Venoms