Complement activation and generation of C3a anaphylatoxin by radiological contrast agents.
Using a new radioimmunoassay for the complement-derived anaphylatoxin C3a, both conventional and new low-osmolality contrast agents have been shown to be capable in vitro of activating complement with C3 conversion. The implications of this for some adverse reactions to contrast agents are briefly discussed.
D000706:Anaphylatoxins / Q000096:biosynthesis*; D003167:Complement Activation / Q000187:drug effects*; D003176:Complement C3 / Q000096:biosynthesis*; D015926:Complement C3a; D003287:Contrast Media / Q000494:pharmacology*; D006801:Humans; D010452:Peptide Biosynthesis; D011863:Radioimmunoassay
D000706:Anaphylatoxins; D003176:Complement C3; D003287:Contrast Media; D015926:Complement C3a