Reactive lesions at the chorio-retinal junction. An experimental study.
Addition of increased amounts of serum and a protein (peroxidase from horseradish) to the culture medium caused structural alterations in previously confluent cultures composed of cells from the human retinal pigment epithelium and choroid. The alterations consisted in the formation of bi- and multi-layered strands, plaques and nodular structures and in the detachment of cells with formation of nude areas. These alterations resemble the frequently observed reactive alterations at the chorio-retinal junction in eyes with inflammation, trauma, retinal detachment and certain degenerative disease processes as the senile disciform macula degeneration.
D000368:Aged; D001769:Blood; D002478:Cells, Cultured; D002829:Choroid / Q000473:pathology*; D003470:Culture Media; D006801:Humans; D007365:Intercellular Junctions / Q000502:physiology*; D010544:Peroxidases; D010857:Pigment Epithelium of Eye / Q000473:pathology*
D003470:Culture Media; D010544:Peroxidases