Broad interspecies cross-reactions of anti-Ia murine alloantibodies.
Interspecies cross-reactive antibodies were detected in a mouse alloantiserum, A.TH anti-A. TL raised against products of the I region genes of the H-2 complex. The cross-reactions were found to extend not only to all mammalian species tested but even to avian and amphibian species. Genetic mapping studies of the cross-reactive antibodies in the mouse indicated that the cross-reaction in all cases were attributable to the antibodies to the I-E subregion gene product, i.e. alpha-chain of the I-E molecule. These results probably indicate that the cross-reactive genes are the homologues of mouse I-E gene and share the common ancestral origin. Possible basis for such unusual interspecies cross-reactions of anti-Ia alloantibodies will be discussed.
D000818:Animals; D002415:Cats; D002645:Chickens / Q000276:immunology; D003429:Cross Reactions; D004285:Dogs; D006168:Guinea Pigs; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006736:Horses / Q000276:immunology; D006801:Humans; D007518:Isoantibodies / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D011892:Rana catesbeiana / Q000276:immunology; D051381:Rats; D013045:Species Specificity; D013154:Spleen / Q000276:immunology
D000949:Histocompatibility Antigens Class II; D007518:Isoantibodies