Properties of lymphocytic choriomeningitis virus interfering particles.
Lymphocytic choriomeningitis virus (LCM virus) interfering particles (IP) were generated in cultivated cells and their properties determined. Unlike true defective interfering (DI) particles, LCM virus IP did not show the phenomenon of enrichment and, consequently, passaging the virus undiluted did not result in their accumulation; in fact, more IP were produced during dilute passages. Furthermore, the progeny of each of 20 plaques contained high numbers of IP. On the basis of these and previous observations, we consider LCM virus IP not deletion mutants but by-products of virus synthesis.
D000818:Animals; D007739:L Cells / Q000382:microbiology; D008217:Lymphocytic choriomeningitis virus / Q000502:physiology*; D051379:Mice; D013997:Time Factors; D014762:Viral Interference; D010948:Viral Plaque Assay; D014771:Virion / Q000502:physiology*; D014776:Virus Cultivation; D014779:Virus Replication