Enflurane induces contracture of in vitro muscle from a patient with malignant hyperthermia.
The possibility of enflurane being an inducer of malignant hyperthermia (MH) was examined by using the contracture test in in vitro muscle from a patient with MH. An administration of 2% enflurane elicited contracture in MH muscle and an elimination of enflurane relaxed this contracture. This result, therefore, strongly suggested that enflurane is the one of the trigger-agents for MH.
D004737:Enflurane / Q000009:adverse effects* / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008305:Malignant Hyperthermia / Q000175:diagnosis / Q000209:etiology*; D009119:Muscle Contraction / Q000187:drug effects
D004737:Enflurane