[Change in the anti-inflammatory activity of nonsteroidal antiphlogistics in conditions of acute hypoxic hypoxia].
It has been shown on animals with experimental histamine edema under acute hypoxic hypoxia that anti-inflammatory properties of the known non-steroidal antiphlogistics and new derivatives of fumaric acid heterylamides administered in a dose of 10% of the LD50 underwent changes. At "altitudes" of 5000 and 10000 m a high enough anti-inflammatory activity was preserved by the drugs that, apart from an anti-exudative action, produced an antihypoxic one. The other non-steroidal anti-inflammatory drugs under study demonstrated either a lowered activity or completely lost it, depending on the "altitude".
D000531:Altitude; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D004008:Diclofenac / Q000627:therapeutic use; D005260:Female; D000860:Hypoxia / Q000150:complications* / Q000188:drug therapy; D007052:Ibuprofen / Q000627:therapeutic use; D007213:Indomethacin / Q000627:therapeutic use; D007249:Inflammation / Q000150:complications / Q000188:drug therapy; D008297:Male; D051379:Mice; D010653:Phenylbutazone / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D004008:Diclofenac; D010653:Phenylbutazone; D007052:Ibuprofen; D007213:Indomethacin
Izmenenie protivovospalitel'noĭ aktivnosti nesteroidnykh antiflogistikov v usloviiakh ostroĭ gipoksicheskoĭ gipoksii.