title: The use of antibiotics in acute-on-chronic bronchitis.
abstract: Acute exacerbations of bronchitis are probably best treated with erythromycin or cotrimoxazole. The rising incidence of ampicillin resistance is reducing its value. Oxytetracycline and cephalosporins are best avoided. Trimethroprim may prove a safer alternative to cotrimoxazole. However, all these conclusions are based on theoretical reasons rather than large comparative trials.
mesh_terms: D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001991:Bronchitis / Q000188:drug therapy*; D004338:Drug Combinations / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D004917:Erythromycin / Q000627:therapeutic use; D006801:Humans; D013420:Sulfamethoxazole / Q000627:therapeutic use; D014295:Trimethoprim / Q000627:therapeutic use; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D004917:Erythromycin; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole