title: [Apolipoprotein B of plasma lipoproteins incorporated in liposomes: immunological properties and organ distribution when administered to rabbits].
abstract: Apolipoprotein B (apo B) isolated from low density lipoproteins (LDL) was built in phospholipid-cholesterol liposomes, with the lipid/protein ratio being equal to 33:1. Such liposomes preserved their integrity, whereas the constituent apo B retained its antigenic properties. After intravenous injection to rabbits the pattern of apo B liposome distribution among organs was similar to that of LDL. Apo B liposomes may be used for goal-oriented transport of some substances to organs and tissues whose cells have specific receptors for apo B-containing lipoproteins.
mesh_terms: D000818:Animals; D001053:Apolipoproteins / Q000008:administration & dosage* / Q000276:immunology / Q000302:isolation & purification / Q000378:metabolism; D001055:Apolipoproteins B; D006801:Humans; D007275:Injections, Intravenous; D008077:Lipoproteins, LDL / Q000097:blood; D008081:Liposomes / Q000008:administration & dosage*; D011817:Rabbits; D014018:Tissue Distribution
chemical_list: D001053:Apolipoproteins; D001055:Apolipoproteins B; D008077:Lipoproteins, LDL; D008081:Liposomes
vernacular_title: Apolipoprotein B plazmennykh lipoproteidov, vstroennyĭ v liposomu: immunologicheskie svoĭstva i raspredelenie mezhdu organami pro vvedenii kroliku.