title: The bone marrow karyotype in seventeen cases of refractory anemia with excess of blasts (RAEB).
abstract: The bone marrow karyotype was studied in 17 patients affected by refractory anemia with excess of blasts (RAEB). A cytogenetic finding common to nearly all the cases is hypodiploidy, present in even quite high percentages. In 3 patients were identified the same interstitial deletion of the long arm of a chromosome 5, present in a percentage varying between 30% and 65%. The presence of this chromosomal anomaly appears to correspond to a slower development of the illness and transformation into acute leukemia seems rare or delayed.
mesh_terms: D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000235:genetics*; D001853:Bone Marrow / Q000648:ultrastructure*; D002478:Cells, Cultured; D002872:Chromosome Deletion; D002905:Chromosomes, Human, 4-5 / Q000648:ultrastructure; D004171:Diploidy; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D008677:Metaphase; D008875:Middle Aged; D011289:Preleukemia / Q000235:genetics*