title: [Therapeutic effect of the beta-adrenergic receptor blocker corgard (nadolol) and its effect on hemodynamics in hypertensive patients].
abstract: The therapeutic effect of the non-cardioselective beta-blocker corgard (nadolol) was examined in 40 patients with stage II essential hypertension. In 22 of those, central, intracardiac and regional hemodynamics were measured echocardiographically and rheographically after 2 and 4 weeks of treatment. Blood pressure dropped significantly by days 8-13 of treatment, as a result of cardiac index reduction mainly due to decreased heart rate. At the same time, a moderate yet significant rise in total peripheral vascular resistance was noted. Intramyocardial tension decreased, as did the thickness of the left-ventricular posterior wall and interventricular septum, which caused a significant (6.74%) reduction in myocardial weight.
mesh_terms: D000328:Adult; D002560:Cerebrovascular Circulation; D004452:Echocardiography; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D009248:Nadolol; D010992:Plethysmography, Impedance; D011412:Propanolamines / Q000627:therapeutic use*; D012039:Regional Blood Flow; D013318:Stroke Volume; D014655:Vascular Resistance
chemical_list: D011412:Propanolamines; D009248:Nadolol
vernacular_title: Lechebnyĭ éffekt blokatora beta-adrenergicheskikh retseptorov korgarda (nadolola) i ego vliianie na gemodinamiku u bol'nykh gipertonicheskoĭ bolezn'iu.