[Effect of polyunsaturated fatty acids in the diet on prostaglandin formation and the activity of the isolated heart].
Experiments on normotensive adult Wistar rats with hearts perfused according to the modified Langendorf technique and Okamoto-Aoki rats with a hereditary determined arterial hypertension kept on the diets with varying content of polyunsaturated acids (PUFA), series 6 and 3, have demonstrated that PUFA deficiency in the diet inhibited prostaglandin (PG) secretion by the heart of hypertensive rats, which was accompanied by the decreased rate of coronary perfusion. It has also been revealed that excess content of linoleic acid in lipid fractions of the diet was followed by an appreciable rise of prostacycline secretion, whereas the linoleic acid increase in the diet by the lowering of the overall amount of PG secreted by the heart of hypertensive rats and drop of the coronary perfusion rate. It has been demonstrated that these changes might be related to the modulations in the content of PUFA, PG precursors, in heart phospholipids.
D000818:Animals; D004032:Diet; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006973:Hypertension / Q000503:physiopathology; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D005231:Fatty Acids, Unsaturated; D011453:Prostaglandins
Vliianie polinenasyshchennykh zhirnykh kislot pishchevogo ratsiona na obrazovanie prostaglandinov i deiatel'nost' izolirovannogo serdtsa.