[Affinity of N-formimidoyl-thienamycin (MK-0787) for beta-lactamases, analysis by a statistical method: correspondence analysis].
N-formimidoyl-thienamycin (MK-0787) is not subject to beta-lactamase hydrolysis. Nevertheless, this compound does show some affinity for the TEM-type penicillinases, cephalosporinases and a few other beta-lactamases. Surprisingly no affinity was found for the penicillinases of the CARB-type. The results thus obtained for affinity constants Ki and Km were submitted to a statistical analysis treatment, i.e. correspondence analysis and hierarchic ascendent classification. This confirms the fact that MK-0787 presents an unusual behaviour towards beta-lactamases.
D002510:Cephalosporinase / Q000378:metabolism; D006868:Hydrolysis; D015378:Imipenem; D007700:Kinetics; D010405:Penicillinase / Q000378:metabolism; D013223:Statistics as Topic; D013845:Thienamycins / Q000378:metabolism*; D001618:beta-Lactamases / Q000378:metabolism*
D013845:Thienamycins; D015378:Imipenem; D002510:Cephalosporinase; D010405:Penicillinase; D001618:beta-Lactamases
Affinité de la N-formimidoyl-thiénamycine (MK-0787) pour les bêta-lactamases, étude par une méthode statistique: analyse des correspondances.