title: The effect of cimetidine on tolbutamide kinetics.
abstract: Although possible on theoretical grounds, no interaction between cimetidine and tolbutamide could be demonstrated in ten healthy volunteers. The plasma tolbutamide concentrations over 12 h following 0.5 g orally were essentially the same before and after 1 and 7 days cimetidine (400 mg twice daily).
mesh_terms: D000328:Adult; D002927:Cimetidine / Q000097:blood / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D014044:Tolbutamide / Q000378:metabolism*
chemical_list: D002927:Cimetidine; D014044:Tolbutamide