d,1-alpha-Tocopheryl acetate (vitamin E): a long term toxicity and carcinogenicity study in rats.
Rats were fed vitamin E at various dietary concentrations providing dosages of up to 2000 mg/kg bodyweight/day for 104 weeks. Vitamin K supplementation suppressed the induced hypoprothrombinaemia. Growth rate and survival were unaltered by treatment, and, apart from a trend towards fewer mammary tumours in females, the tumour profile was unaffected. Changes in serum liver enzyme activity and in the appearance of the hepatic macrophages suggested a limited hepatic response to vitamin E overload.
D000818:Animals; D001772:Blood Cell Count; D002273:Carcinogens; D004032:Diet; D005260:Female; D006128:Growth / Q000187:drug effects; D008099:Liver / Q000201:enzymology; D008297:Male; D009929:Organ Size; D011517:Prothrombin Time; D051381:Rats; D012737:Sex Factors; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000633:toxicity; D014812:Vitamin K / Q000494:pharmacology; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D002273:Carcinogens; D014812:Vitamin K; D014810:Vitamin E; D024502:alpha-Tocopherol; D024505:Tocopherols