Alteration in natural resistance of sarcoma 180 tumor to Bouvardin (NSC 259968) following hyperthermia.
Sarcoma-180 (S-180) tumor cells grown in Swiss mice displayed natural resistance to Bouvardin (NSC 259968) when administered alone in a single dose or in multiple doses. Hyperthermia treatment (43 degrees C for 1 hr) alone did not show any tumor growth reduction. However, the drug combined with hyperthermia markedly reduced tumor growth suggesting that hyperthermia alters the natural resistance of S-180 cells to Bouvardin.
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000008:administration & dosage*; D003131:Combined Modality Therapy; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D006979:Hyperthermia, Induced; D051379:Mice; D008815:Mice, Inbred Strains; D010456:Peptides, Cyclic / Q000008:administration & dosage*; D012510:Sarcoma 180 / Q000628:therapy*
D000972:Antineoplastic Agents, Phytogenic; D010456:Peptides, Cyclic; C018234:bouvardin