An intermediary role for the tremorgenic mycotoxin TR-2 in the biosynthesis of verruculogen.
14C-Labelled compound TR-2, a tremorgenic mycotoxin, was administered to Penicillium raistrickii in submerged fermentation. Half of the added radiolabel was taken up by the fungus during the 60 h incubation period and the secondary metabolites subsequently isolated, principally verruculogen but also fumitremorgin B, were found to be radiolabelled. The efficiency of biosynthetic incorporation of TR-2 into verruculogen within the mycelium was at least 35%, demonstrating for the first time an intermediary role for TR-2. Fumitremorgin B was also TR-2-derived but may not be an important intermediate in verruculogen biosynthesis.
D055598:Chemical Phenomena; D002621:Chemistry; D007211:Indoles / Q000096:biosynthesis* / Q000378:metabolism*; D009183:Mycotoxins / Q000378:metabolism*; D010407:Penicillium / Q000378:metabolism*
D007211:Indoles; D009183:Mycotoxins; C009658:verruculogen; C039287:TR-2 mycotoxin; C039286:fumitremorgin B