The acetylcholinesterase abnormality in dystrophic mice is a reflection of a maturational defect.
Juvenile mice of the ReJ/129 strain exhibit a distribution of acetylcholinesterase molecular forms that is similar to the pattern previously observed in dystrophic mice. The change to an adult distribution of the enzyme occurs at about 3 weeks of age which is also when dystrophic signs first become evident. It is suggested that dystrophic mouse muscle fails to mature with respect to the molecular forms of acetylcholinesterase.
D000110:Acetylcholinesterase / Q000235:genetics*; D000375:Aging; D000818:Animals; D003964:Diaphragm / Q000201:enzymology; D005260:Female; D008297:Male; D051379:Mice; D008818:Mice, Neurologic Mutants; D024510:Muscle Development; D009130:Muscle, Smooth / Q000201:enzymology; D009132:Muscles / Q000201:enzymology; D009137:Muscular Dystrophy, Animal / Q000201:enzymology*; D009929:Organ Size
D000110:Acetylcholinesterase