Familial pericentric inversion of the Y chromosome.
Cytogenetic investigation of a healthy couple with 4 spontaneous abortions revealed a pericentric inversion of the Y chromosome. The same abnormality was found in three other members of the family. All of them have normal children without fetal wastage. This finding suggests that the pericentric inversion of the Y chromosome affects neither the phenotype nor reproductive performance.
D000022:Abortion, Spontaneous / Q000235:genetics; D000328:Adult; D002871:Chromosome Banding; D007446:Chromosome Inversion; D005260:Female; D006801:Humans; D007621:Karyotyping; D008297:Male; D010375:Pedigree; D010641:Phenotype; D011247:Pregnancy; D014998:Y Chromosome / Q000648:ultrastructure*