Evidence for dopamine-containing renal nerves.
The existence of the specific renal DA1 postsynaptic receptor for dopamine (DA) has prompted the search for a counterpart dopaminergic innervation. In the canine kidney there is an increased proportion of DA as a percentage of norepinephrine (NE), and both NE and DA are lost after chronic denervation. In the rat and dog, renal stimulation increases the net secretion of both NE and DA; renal denervation eliminates NE but only partially reduces DA secretion. Histological techniques have identified DA-containing neuronal elements in the kidney. Thus there is growing evidence for a prejunctional dopaminergic counterpart to the DA1 receptor.
D000818:Animals; D004285:Dogs; D004298:Dopamine / Q000378:metabolism*; D006651:Histocytochemistry; D007668:Kidney / Q000294:innervation* / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism*; D013045:Species Specificity; D014018:Tissue Distribution
D011954:Receptors, Dopamine; D004298:Dopamine; D009638:Norepinephrine