Genotoxicity of chlordiazepoxide hydrochloride on the bone-marrow cells of Swiss mice.
The mutagenic effect of chlordiazepoxide hydrochloride was evaluated in the bone-marrow cells of Swiss mice by the micronucleus test. A comparative study of the drug was made by oral and intraperitoneal administrations containing 187.5, 375 and 562 mg/kg body weight and 67, 134 and 201 mg/kg body weight respectively, corresponding to three sublethal doses of 1/4, 1/2, and 3/4 LD50, respectively. Bone-marrow preparations were made and slides scored for the presence of micronuclei in the developing erythrocytes. The results showed that the drug chlordiazepoxide induced a significant increase of micronuclei in the polychromatic erythrocytes by both routes of administration.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D002707:Chlordiazepoxide / Q000633:toxicity*; D002869:Chromosome Aberrations; D051379:Mice
D002707:Chlordiazepoxide