title: Influence of testosterone on protein/peptide secretion as characterized by the formation of granular vesicles in rat and mouse pinealocytes. An in vitro study.
abstract: In the present study, using an in vitro system, the effect of testosterone on protein/peptide secretion in mouse and rat pinealocytes as characterized by the formation of granular vesicles (GV) has been studied. In both species testosterone induces a significant increase in the number of GV. This effect, however, is observed only when the pineals are cultured in a noradrenaline-free medium. These results clearly demonstrate that testosterone, at least under these in vitro conditions, is involved in the regulation of protein/peptide secretion, and point to the importance of pineal proteic/peptidic "hormones" in pineal endocrinology.
mesh_terms: D000818:Animals; D008297:Male; D008550:Melatonin / Q000378:metabolism; D051379:Mice; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D010455:Peptides / Q000378:metabolism*; D010870:Pineal Gland / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats; D013045:Species Specificity; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D009419:Nerve Tissue Proteins; D010455:Peptides; D013739:Testosterone; D008550:Melatonin