[Effect of cianidanol (KB-53) on delayed skin reactions in mice compromised by carbon tetrachloride and 1-naphthylisothiocyanate].
A study was carried out to investigate the influence of 3 kinds of hepatotoxic agents on the peripheral blood leucocyte population, the splenocyte population and the delayed type hypersensitivity (DTH) in mice. These parameters were not affected by the intraperitoneal injection of D-galactosamine (Gal). The intensity of picryl chloride induced DTH (PC-DTH) in mice was significantly lowered with the administration of carbon tetrachloride (CCl4) and 1-naphtylisothiocyanate (ANIT) in a dose-dependent manner after the mice were sensitized to picryl chloride (PC) from one to three days after the subcutaneous injection of CCl4 and ANIT. However the peripheral blood leucocyte population and splenocyte population were not affected by these chemicals. The lowering effect of CCl4 and ANIT on PC-DTH was somewhat weakened when PC sensitization was performed seven days after the injection of CCl4 and ANIT. No lowering effect was observed when PC sensitization was performed fourteen days after the injection of CCl4 and ANIT. The intensity of PPD induced DTH (PPD-DTH) was also lowered by the administration of CCl4 and ANIT when the sensitization to tubercle bacilli was performed three days after the injection of CCl4 and ANIT. Cianidanol (KB-53) prevented the decrease of PC-DTH and PPD-DTH in the mice injected with CCl4 and ANIT in a dose-dependent manner, but did not affect DTH in normal mice. So it seems that KB-53 has an immunostimulating effect on decreased cellular immunity.
D015058:1-Naphthylisothiocyanate / Q000633:toxicity*; D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002392:Catechin / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects; D008099:Liver / Q000187:drug effects*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013154:Spleen / Q000187:drug effects; D013861:Thiocyanates / Q000633:toxicity*
D001578:Benzopyrans; D005419:Flavonoids; D013861:Thiocyanates; D015058:1-Naphthylisothiocyanate; D002392:Catechin; D002251:Carbon Tetrachloride