Production of lymphokines by murine cortisone-resistant thymocytes, stimulated by concanavalin A. I. Comparison of optimal culture conditions for proliferative response and interleukin-2 production.
The conditions for optimal proliferation and production of interleukin-2 by cortisone resistant thymocytes stimulated by concanavalin A were compared. The results show that identical culture conditions are optimal for both responses but peak of interleukin-2 production precedes the peak of proliferation.
D000818:Animals; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006854:Hydrocortisone / Q000008:administration & dosage*; D007376:Interleukin-2 / Q000096:biosynthesis*; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008807:Mice, Inbred BALB C; D013601:T-Lymphocytes / Q000145:classification / Q000187:drug effects* / Q000276:immunology
D007376:Interleukin-2; D003208:Concanavalin A; D006854:Hydrocortisone