Radiation damage to the erythrocyte membrane in the presence of radical anions. I.
Irradiated porcine erythrocytes demonstrated increased osmotic fragility, which was enhanced by the addition of anions. The extent of the damage produced by the secondary radicals depended on the kind of anion and conditions of irradiation. The most pronounced changes occurred in the presence of azide, whereas bromide and thiocyanate gave rise to a smaller enhancement of osmotic fragility. Irradiation of cells in air or N2O revealed that radical anions have more damaging effects on porcine erythrocytes in air.
D000818:Animals; D001386:Azides / Q000494:pharmacology*; D001965:Bromides / Q000494:pharmacology; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000528:radiation effects*; D004912:Erythrocytes / Q000528:radiation effects*; D005609:Free Radicals; D005720:Gamma Rays; D009996:Osmotic Fragility / Q000187:drug effects / Q000528:radiation effects; D010100:Oxygen; D013552:Swine; D013861:Thiocyanates / Q000494:pharmacology
D001386:Azides; D001965:Bromides; D005609:Free Radicals; D013861:Thiocyanates; D010100:Oxygen