Topical timolol and the nursing mother.
A 34-year-old nursing woman with elevated intraocular pressure voluntarily and without our knowledge applied 0.5% timolol maleate twice daily to her right eye. A milk sample 1.5 hours after administration of drug showed a much higher level of timolol (5.6 ng/mL) than a plasma sample drawn at the same time (0.93 ng/mL). Three control milk specimens showed no measurable levels of timolol. The patient's milk sample 12 hours after her last timolol dose contained 0.5 ng/mL of timolol. On the basis of our calculations, timolol should be used with caution by nursing mothers.
D000287:Administration, Topical; D000328:Adult; D001942:Breast Feeding; D005260:Female; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008895:Milk, Human / Q000032:analysis*; D011247:Pregnancy; D011412:Propanolamines / Q000032:analysis*; D013999:Timolol / Q000008:administration & dosage / Q000032:analysis* / Q000097:blood
D011412:Propanolamines; D013999:Timolol