Age-related loss of Lyt-1,2 cells in C58 mice results in susceptibility to lactic dehydrogenase virus-induced polioencephalomyelitis.
C58 mice (aged greater than or equal to 5 months) are susceptible to age-dependent polioencephalomyelitis, a paralytic central nervous system disease induced by lactic dehydrogenase virus. Susceptibility results from the loss of protective T cells. Data are presented showing a positive correlation between the age-related loss of Lyt-1,2 cells and the development of susceptibility to neuroparalytic lactic dehydrogenase virus infection.
D000375:Aging; D000818:Animals; D004198:Disease Susceptibility; D004679:Encephalomyelitis / Q000276:immunology*; D007772:Lactate dehydrogenase-elevating virus / Q000472:pathogenicity*; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology*; D011051:Poliomyelitis / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation