title: [Thymus-dependent and thymus-independent blood lymphocytes in multiple sclerosis].
abstract: In 65 patients with various clinical manifestations of disseminated sclerosis, the percentage and absolute content of T- and B-lymphocytes, as well as of the three classes of immunoglobulins (IgA, IgG, and IgM) were examined. Use was made of spontaneous and active rosette formation. B-lymphocytes were determined by the immunofluorescent method of detecting superficial immunoglobulins, and by complementary rosette formation. The serum immunoglobulins were determined by the radial immunodiffusion method. The content of T-lymphocytes in patients was found to vary, which was largely observed in patients with the remitting course of the disease. The content of B-lymphocytes and immunoglobulins G and M was found to be increased significantly, this increase being observed especially frequently at active stages of the disease. The importance of the discovered anomalies in the immune status for the disease pathogenesis is discussed.
mesh_terms: D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood / Q000276:immunology*; D013601:T-Lymphocytes
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins
vernacular_title: Timuszavisimye i timusnezavisimye limfotsity krovi pri rasseiannom skleroze.