Bleeding tendency possibly related to increased plasma antithrombin III activity in patient treated with piroxicam.
A patient with chronic rheumatoid arthritis under treatment with steroids was given piroxicam (Feldene) for relief of pain and disability. Overt cutaneous and occult gastrointestinal bleeding developed after two months of treatment. Bleeding subsided and laboratory values returned to normal upon discontinuation of the drug.
D000328:Adult; D000990:Antithrombin III / Q000032:analysis*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001760:Bleeding Time; D002908:Chronic Disease; D004438:Ecchymosis / Q000139:chemically induced*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D006801:Humans; D010894:Piroxicam; D013843:Thiazines / Q000009:adverse effects*
D013843:Thiazines; D010894:Piroxicam; D000990:Antithrombin III