title: Cinnarizine in the prophylaxis of car sickness in children.
abstract: An open study was carried out in 79 children known to be susceptible to car sickness to assess the efficacy and tolerance of cinnarizine used prophylactically. Each child received one 15 mg cinnarizine tablet 2 hours before a long car journey and a further half-tablet every 8 hours thereafter, if required. The results of the children's assessments indicated that 81% considered the preparation either 'good' or 'excellent' and 69% of the 68 who had previously received other medication for travel sickness rated it 'better' or 'much better'. Only 4% of the children vomited and only 14% felt sleepy or drowsy. All but 3 of the 52 doctors who participated were prepared to give cinnarizine again to their charges based on the experience of this study.
mesh_terms: D002648:Child; D002675:Child, Preschool; D002936:Cinnarizine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D009041:Motion Sickness / Q000188:drug therapy / Q000517:prevention & control*; D010879:Piperazines / Q000627:therapeutic use*
chemical_list: D010879:Piperazines; D002936:Cinnarizine