Tolerability of iohexol after injection into healthy volunteers.
The effects of iohexol, a new non-ionic contrast medium, after intravenous injection into humans are reported. After injection of small doses into 2 subjects, iohexol was injected intravenously into 20 healthy male volunteers in doses of 125 to 500 mg I/kg body weight. A large number of physiologic, biochemical, hematologic and pharmacokinetic parameters were analysed. The results indicated that iohexol was well tolerated and that clinical trials in patients could be undertaken.
D000328:Adult; D001780:Blood Coagulation Tests; D001794:Blood Pressure / Q000187:drug effects; D003287:Contrast Media / Q000009:adverse effects*; D004341:Drug Evaluation; D004361:Drug Tolerance; D006339:Heart Rate / Q000187:drug effects; D006403:Hematologic Tests; D006801:Humans; D007275:Injections, Intravenous; D007463:Iodobenzoates / Q000009:adverse effects*; D007472:Iohexol; D008297:Male; D008875:Middle Aged; D010979:Platelet Function Tests; D013960:Thyroid Function Tests; D014283:Triiodobenzoic Acids / Q000009:adverse effects* / Q000494:pharmacology
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D007472:Iohexol