Quantitation of complement proteins in rheumatic disease.
Complement proteins serve a critical function in the non-antigen-specific elimination of foreign substances and organisms and of immune complexes. Studies of genetic and acquired alterations of complement proteins have provided insights into the pathophysiology of a number of rheumatic diseases, especially those in which immune complexes are believed to have a role in pathogenesis. Complement levels may be helpful in the management of some patients with SLE or vasculitis, and in evaluation of synovial, pleural and pericardial fluids.
D001172:Arthritis, Rheumatoid / Q000276:immunology; D003165:Complement System Proteins / Q000032:analysis*; D004198:Disease Susceptibility; D008040:Genetic Linkage; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D011110:Polymorphism, Genetic; D012216:Rheumatic Diseases / Q000235:genetics / Q000276:immunology*; D013582:Synovial Fluid / Q000032:analysis; D014657:Vasculitis / Q000276:immunology
D003165:Complement System Proteins