Antibacterial activity of cefoperazone alone and in combination against cephalosporinase-producing Enterobacter cloacae.
The activity of cefoperazone against a strain with an inducible cephalosporinase and a mutant that produces the enzyme constitutively indicates that the low inducer activity of this antibiotic plays an important role in its activity against Enterobacter cloacae.
D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002438:Cefoperazone / Q000494:pharmacology*; D002510:Cephalosporinase / Q000378:metabolism*; D003023:Cloxacillin / Q000494:pharmacology; D004347:Drug Interactions; D004754:Enterobacter / Q000187:drug effects* / Q000201:enzymology; D004755:Enterobacteriaceae / Q000187:drug effects*; D001618:beta-Lactamases / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000667:Ampicillin; D002438:Cefoperazone; D002510:Cephalosporinase; D001618:beta-Lactamases; D003023:Cloxacillin