Antibody to Ro in a population of patients with systemic lupus erythematosus: distribution, clinical and serological associations.
Anti-Ro occurs in 1/3 of systemic lupus erythematosus (SLE) patients with equal prevalence at all ages, ages at onset of SLE, and disease durations. In SLE anti-Ro is associated with xerophthalmia but not rheumatoid factor (RF). Anti ds-DNA rather than anti-Ro or RF is associated with SLE arthritis. We found a positive correlation between increased anti ds-DNA levels and the prevalence of anti-Ro in SLE patients' sera. This reinforces the thesis that anti-Ro may have considerable value as a diagnostic marker for SLE.
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis* / Q000276:immunology; D000941:Antigens / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001324:Autoantigens; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D020733:RNA, Small Cytoplasmic; D012217:Rheumatoid Factor / Q000032:analysis; D012261:Ribonucleoproteins; D012859:Sjogren's Syndrome / Q000276:immunology; D000099207:SS-A Antigen
D000974:Antibodies, Antinuclear; D000941:Antigens; D001324:Autoantigens; D020733:RNA, Small Cytoplasmic; D012217:Rheumatoid Factor; D012261:Ribonucleoproteins; D000099207:SS-A Antigen; C116006:RO60 protein, human; C035356:SS-A antibodies