Dantrolene: evidence for effects on Na permeability properties of the nodal membrane.
The effects of dantrolene on myelinated frog nerve fibers were studied in voltage clamp experiments. Dantrolene shifted the potential-dependent parameters describing Na+ permeability towards more negative membrane potentials. The findings are interpreted as a change in the negative surface charge of the membrane.
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D003620:Dantrolene / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D009413:Nerve Fibers, Myelinated / Q000187:drug effects; D011893:Rana esculenta; D012964:Sodium / Q000378:metabolism*
D012964:Sodium; D003620:Dantrolene