[Topographic distribution of arsenous anhydride in pregnant mice using macroscopic autoradiography].
Radioactive arsenic trioxide is given to pregnant mice in order to complete a recent pharmacokinetics study in the same species and to investigate an eventual transplacental passage, whole body autoradiographic study is performed in the mouse after a single administration of that compound considering its fast elimination process. Both in mice and foetus a fixation has particularly kept our attention: the radioactivity is well fixed in the bone marrow and it might be related to some malformations which occur in the newborns.
D000818:Animals; D001151:Arsenic / Q000378:metabolism*; D000077237:Arsenic Trioxide; D001152:Arsenicals; D001345:Autoradiography; D005260:Female; D005333:Fetus / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D051379:Mice; D010087:Oxides; D011247:Pregnancy; D011270:Pregnancy, Animal; D011868:Radioisotopes; D013997:Time Factors
D001152:Arsenicals; D010087:Oxides; D011868:Radioisotopes; D001151:Arsenic; D000077237:Arsenic Trioxide
Etude de la distribution topographique de l'anhydride arsenieux chez la souris gestante par autoradiographie macroscopique.