[Interaction of acetylcholine and tubocurarine with protein molecules of the actin complex and phosphatidylcholine].
By means of surface Wilhelmi weight type changes of monomolecular layer properties of some proteins and lipids at the air--water boundary have been studied during acetylcholine and tubocurarine injection in the subphase. Active interaction of acetylcholine and tubocurarine molecules with monolayers of actin, myosin and phosphatidylcholine was observed, while the properties of human serum albumin (HSA) and cholesterine were not influenced by the same physiologically active substances. These substances had no effect on the area of monolayers and on other physico-chemical parameters of HSA and cholesterine. On the other hand when acetylcholine is present in the subphase of phosphatidylcholine monolayer the velocity of HSA penetration in these monolayers in sharply decreased.
D000109:Acetylcholine; D000199:Actins / Q000378:metabolism*; D000818:Animals; D006801:Humans; D008081:Liposomes; D009132:Muscles; D010713:Phosphatidylcholines / Q000378:metabolism*; D011817:Rabbits; D012709:Serum Albumin; D014403:Tubocurarine
D000199:Actins; D008081:Liposomes; D010713:Phosphatidylcholines; D012709:Serum Albumin; D000109:Acetylcholine; D014403:Tubocurarine
Vzaimodeĭstvie atsetilkholina i tubokurarina s molekulami belkov aktinovogo kompleksa i fosfatidilkholina.