Amygdala and pyriform cortex kindling in vasopressin deficient rats (Brattleboro strain).
Homozygous and heterozygous Brattleboro rats and Long--Evans control rats were subjected to repeated electrical stimulation of the amygdala or pyriform cortex in a kindling paradigm. The homozygous Brattleboro group stimulated in the amygdala was retarded in its kindling rate relative to heterozygous Brattleboros and Long--Evans controls. The retarded kindling rate of the homozygous Brattleboros stimulated in the amygdala is attributed to a delay in seizure development at stages 1 and 2 which suggests that vasopressin may be necessary for normal kindling from the amygdala to take place.
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D005071:Evoked Potentials; D007696:Kindling, Neurologic; D008032:Limbic System / Q000502:physiology*; D008297:Male; D009473:Neuronal Plasticity; D051381:Rats; D011910:Rats, Brattleboro; D014667:Vasopressins / Q000502:physiology*
D014667:Vasopressins