Detection of common antigenic sites in lethal proteins of non-related animal venoms.
Monoclonal antibodies neutralizing specific coelenterate lethal toxins were used to determine the presence of homologous antigenic sites on toxin proteins of a rattlesnake (Crotalus durissus terrificus), a hornet (Vespa orientalis) and the sea wasp (Chironex fleckeri). An anti-Portuguese man-o'war toxin antibody was found useful for isolating a C. d. terrificus toxin.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D001666:Binding Sites, Antibody; D003429:Cross Reactions; D003435:Crotalid Venoms / Q000276:immunology; D011506:Proteins / Q000032:analysis*; D014688:Venoms / Q000032:analysis / Q000276:immunology*; D014862:Wasp Venoms / Q000276:immunology
D000911:Antibodies, Monoclonal; D003435:Crotalid Venoms; D011506:Proteins; D014688:Venoms; D014862:Wasp Venoms