Staphylococcus aureus inhibits contact sensitivity to oxazolone by activating suppressor B cells in mice.
Killed Staphylococcus aureus strain Cowan I cells inhibit contact sensitivity to oxazolone in mice, when given intravenously 24-72 h before sensitization. With transfer experiments it was found that the cells responsible for the suppression are antigen-specific, nylon-adherent, resistant to antitheta serum + C, and sensitive to anti-mouse Ig serum + C. These suppressor B cells bear anti-oxazolone immunoglobulins and appear to exert their suppressive activity by preventing the contact sensitizer from reaching the specific reactive T cells.
D000818:Animals; D001402:B-Lymphocytes / Q000145:classification / Q000276:immunology*; D003877:Dermatitis, Contact / Q000276:immunology*; D005260:Female; D007108:Immune Tolerance; D007111:Immunity, Cellular; D007116:Immunization, Passive; D008198:Lymph Nodes / Q000166:cytology / Q000637:transplantation; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010081:Oxazolone / Q000008:administration & dosage / Q000276:immunology; D013203:Staphylococcal Infections / Q000276:immunology; D013209:Staphylococcal Vaccines / Q000008:administration & dosage* / Q000276:immunology
D013209:Staphylococcal Vaccines; D010081:Oxazolone