Pharmacokinetics of digoxin in pregnancy.
Digoxin-renal-clearance, creatinine-clearance, 24-h urine elimination of digoxin and serum digoxin were studied in 15 patients in the third trimester of pregnancy and 6 to 12 weeks post-partum. There was significant fall post-partum in the first three. There was also a significant fall post-partum in serum digoxin levels. This finding was unexpected, but may be due to heightened absorption exceeding increased elimination because of the physiological status in pregnancy.
D003404:Creatinine / Q000097:blood; D004077:Digoxin / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007700:Kinetics; D010349:Patient Compliance; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy / Q000378:metabolism*
D004077:Digoxin; D003404:Creatinine