[Prevention of stress and hypoxic damage to the heart using the beta-blockader inderal].
Administration of the beta-blocker Inderal, 1 mg/kg, prior to emotional-painful stress was shown to prevent post-stress damage of contractility in isolated rat hearts. Inderal enhances animal heart resistance to hypoxic and reoxygenation damage and prevents progress thereof after the stress.
D000818:Animals; D003327:Coronary Disease / Q000188:drug therapy; D006321:Heart / Q000503:physiopathology; D006331:Heart Diseases / Q000209:etiology / Q000517:prevention & control*; D006439:Hemodynamics / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D010100:Oxygen / Q000494:pharmacology; D010101:Oxygen Consumption; D011433:Propranolol / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000150:complications*
D011433:Propranolol; D010100:Oxygen
Preduprezhdenie stressornykh i gipoksicheskikh povrezhdeniĭ serdtsa s pomoshch'iu beta-blokatora inderala.