[Functional activity of the regional lymph nodes in breast cancer patients].
The study was concerned with the correlation between the reaction of T- and B-lymphocytes in regional lymph nodes, clinico-morphological pattern of tumor and immunological indexes. Three levels of functional activity of lymph nodes were established in 15,33 and 52% of patients, respectively, after an evaluation of the condition of structural and functional T- and B-dependent areas and the concentrations of T- and B-rosette-forming cells. An inverse correlation was observed between the functional activity of lymph nodes and the clinico-morphological criteria of tumor malignancy. Conversely, a direct correlation was established between cellular reactions in lymph nodes and the indexes of immune response in 52-85.7%. T-population of lymphocytes was shown to be a factor of antitumor defense. The role of lymph nodes in immunologic surveillance and the prognostic value of the said morpho-functional changes are discussed.
D001402:B-Lymphocytes / Q000276:immunology; D001943:Breast Neoplasms / Q000276:immunology* / Q000473:pathology; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008198:Lymph Nodes / Q000276:immunology* / Q000473:pathology; D008207:Lymphatic Metastasis; D008875:Middle Aged; D011379:Prognosis; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology
Funktsional'naia aktivnost' regionarnykh limfaticheskikh uzlov u bol'nykh rakom molochnoĭ zhelezy.