Colonic release of 5-amino salicylic acid from an oral preparation in active ulcerative colitis.
5-amino salicylic acid coated with acrylic based resin was given orally to eight patients with active ulcerative colitis. Abdominal X-rays confirmed that the preparation released its contents in the terminal ileum and proximal colon. Differences between individuals were marked; the plasma 'concentration-time profile' reflected variations in the time taken for tablets to reach the terminal ileum.
D000328:Adult; D000368:Aged; D000636:Aminosalicylic Acids / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D003093:Colitis, Ulcerative / Q000378:metabolism*; D003106:Colon / Q000378:metabolism*; D005260:Female; D006801:Humans; D007422:Intestines / Q000000981:diagnostic imaging; D008297:Male; D019804:Mesalamine; D008875:Middle Aged; D011859:Radiography; D013608:Tablets, Enteric-Coated; D013997:Time Factors
D000636:Aminosalicylic Acids; D013608:Tablets, Enteric-Coated; D019804:Mesalamine