Anti-inflammatory activity of S-adenosyl-L-methionine: interference with the eicosanoid system.
S-adenosyl-L-methionine (SAMe) displays anti-inflammatory as well as antalgic activity without damaging the gastrointestinal mucosa in experimental animals. In fact, carrageenin-induced edema in rats and writhings provoked in mice by phenylquinone and acetic acid are controlled by SAMe in a dose dependent manner. Since PG-like substance concentration in the inflammatory exudate decreased in SAMe-treated animals the mode of action of this compound is also discussed, in view of SAMe ability to interfere with the eicosanoid system.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001095:Arachidonic Acids / Q000378:metabolism*; D004064:Digestive System / Q000187:drug effects; D004487:Edema / Q000188:drug therapy; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007249:Inflammation / Q000378:metabolism; D008297:Male; D051379:Mice; D011453:Prostaglandins / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012436:S-Adenosylmethionine / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D011453:Prostaglandins; D012436:S-Adenosylmethionine