Inhibitory effect of butylated hydroxyanisole and ethoxyquin on the induction of neoplastic lesions in rat liver after an initial treatment with N-ethyl-N-hydroxyethylnitrosamine.
The effect of butylated hydroxyanisole (BHA) and ethoxyquin (EQ) on hepatocarcinogenesis initiated with N-ethyl-N-hydroxyethylnitrosamine in rats was investigated. The results clearly demonstrated that BHA and EQ inhibited the development of gamma-glutamyltranspeptidase - positive foci, hyperplastic nodules and hepatocellular carcinomas in the rat system employed.
D000818:Animals; D000840:Anisoles / Q000494:pharmacology*; D001835:Body Weight; D002083:Butylated Hydroxyanisole / Q000494:pharmacology*; D002273:Carcinogens / Q000633:toxicity*; D004052:Diethylnitrosamine / Q000031:analogs & derivatives / Q000633:toxicity*; D004347:Drug Interactions; D002149:Energy Intake; D005015:Ethoxyquin / Q000494:pharmacology*; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D009602:Nitrosamines / Q000633:toxicity*; D011336:Probability; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344
D000840:Anisoles; D002273:Carcinogens; D009602:Nitrosamines; D011804:Quinolines; C023845:N-ethyl-N-hydroxyethylnitrosamine; D002083:Butylated Hydroxyanisole; D004052:Diethylnitrosamine; D005015:Ethoxyquin