Alteration of pharmacokinetics after halving a slow-release theophylline tablet.
A study was carried out in 10 healthy volunteers to determine the effects on the bioavailability of theophylline from a biconvex-shaped, slow-release 400 mg theophylline tablet formulation when the tablet was taken whole or as two separate halves in a single dose. The subjects took one or other dosage regimen on different occasions separated by a 7-day washout period. The results showed that absorption was faster and plasma levels were higher when the 400 mg tablet was taken as 2 halves.
D000328:Adult; D003692:Delayed-Action Preparations; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D013607:Tablets; D013806:Theophylline / Q000008:administration & dosage* / Q000097:blood
D003692:Delayed-Action Preparations; D013607:Tablets; D013806:Theophylline