Charge movement in skeletal muscle fibers paralyzed by the calcium-entry blocker D600.
We report measurements of nonlinear charge movement in frog skeletal muscle fibers paralyzed by the calcium-entry blocker [Schwartz, A. & Taira, N., eds. (1983) Circ. Res. 52, Part II, Number 2, 1-181.] D600 (methoxyverapamil, recently renamed gallopamil). Nonlinear charge movement was not seen in such fibers, suggesting that the drug severs the link between membrane depolarization and the main components of charge movement. This is the only pharmacological agent that blocks the main components of charge movement.
D000818:Animals; D004553:Electric Conductivity / Q000187:drug effects; D005711:Gallopamil / Q000633:toxicity*; D008564:Membrane Potentials / Q000187:drug effects; D009132:Muscles / Q000187:drug effects / Q000503:physiopathology*; D010243:Paralysis / Q000503:physiopathology*; D011188:Potassium / Q000494:pharmacology; D011896:Rana temporaria; D014700:Verapamil / Q000633:toxicity*
D005711:Gallopamil; D014700:Verapamil; D011188:Potassium