Adrenergic and cholinergic receptors in human nasal mucosa in cases of nasal allergy.
We have demonstrated for the first time alpha-1 adrenergic, beta-adrenergic, and muscarinic cholinergic receptors in human nasal mucosa obtained from patients with nasal allergy or sinusitis. Using the radioligand 3H-prazosin, 3H-dihydroalprenolol (3H-DHA) and 3H-quinaclidinyl benzilate (3H-QNB), we determined the receptor densities (Bmax) and affinities (KD) of alpha-1, beta, and muscarinic receptors. There was an increased number of muscarinic receptors and a decreased number of alpha-1, beta receptors in patients with nasal allergy but not in those with sinusitis. Binding affinities (KD) of alpha-1, beta, and muscarinic receptors were unchanged in all patients with nasal allergy and sinusitis. Disorders of the autonomic nerve receptors appear to play a definite role in pathology of nasal allergy.
D000328:Adult; D004082:Dihydroalprenolol / Q000378:metabolism; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D009297:Nasal Mucosa / Q000378:metabolism*; D011224:Prazosin / Q000378:metabolism; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D011869:Radioligand Assay; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000378:metabolism*; D012221:Rhinitis, Allergic, Perennial / Q000378:metabolism*; D012852:Sinusitis / Q000378:metabolism*
D011941:Receptors, Adrenergic; D011976:Receptors, Muscarinic; D004082:Dihydroalprenolol; D011813:Quinuclidinyl Benzilate; D011224:Prazosin