Short communication. Photochemical reactions of riboflavin: covalent binding to DNA and to poly (dA) . poly (dT).
Standard phototherapy illumination of human cells in the presence of riboflavin is known to produce single-strand breaks in intracellular DNA. A new photochemical reaction is described between riboflavin and purified DNA in which an adduct is formed. Unlike the previously described oxygen-dependent reaction between light-activated riboflavin and deoxyguanosine, this new photochemical reaction is oxygen-independent and involves deoxyadenosine or thymidine.
D000818:Animals; D002417:Cattle; D004247:DNA / Q000528:radiation effects; D003839:Deoxyadenosines; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000628:therapy; D010100:Oxygen; D010777:Photochemistry; D010789:Phototherapy / Q000009:adverse effects*; D011067:Poly dA-dT; D011089:Polydeoxyribonucleotides; D012256:Riboflavin; D013936:Thymidine
D003839:Deoxyadenosines; D011089:Polydeoxyribonucleotides; D011067:Poly dA-dT; D004247:DNA; D010100:Oxygen; D012256:Riboflavin; D013936:Thymidine