[Indolin-2,3-dione-3,N-alkylamino- and 3,N-piperazinoacetylhydrazones, new substances with anti-ulcer and antisecretory activity].
New indolin-2,3-dione-3,N-alkylamino- and 3,N-piperazinoacetylhydrazones were synthesized and the gastric antisecretory activity was tested. Most of the active products were selected to evaluate the inhibition of peptic ulcer induced by phenylbutazone or by stress (restraint and cold).
D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D010653:Phenylbutazone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000517:prevention & control
D000897:Anti-Ulcer Agents; D006835:Hydrazones; D010653:Phenylbutazone
Indolin-2,3-dione-3,N-alchilamino- e 3,N-piperazinoacetidrazoni, nuove sostanze ad attività antiulcerogena ed antisecretiva.