title: [Premedication with flunitrazepam, lormetazepam or pethidine-promethazine. Psychometric study of subjective conditions].
abstract: In the course of a clinical study oral administration of two different diazepine derivatives as well as i.m. injection of pethidine and promethazine have been explored with a view to their anxiolytic, sedating and hypnotic action. The study involved 128 patients, randomized into four groups. Group 1 received flunitrazepam 1,5-2 mg p.o. only the evening before operation to group 2 flunitrazepam 1,5-2 p.o. was administered the evening before and the morning of the operation, group 3 were given lormetazepam 2-2,5 mg p.o. at the same time as group 2, in group 4 nitrazepam, 5 mg p.o. the evening before operation and pethidine, 50-100 mg combined with promethazine, 25 mg was given i.m. 60 min before surgery. In group 1 anxiolytic and sedating effect of flunitrazepam were not persistent enough to provide the patient with adequate premedication until the onset of surgery. Intensive sedation and fatigue as well as minimum recollection were observed under medication 2, however, increase in anxiety and depression as well as deterioration of mood were not prevented. Under medication 3 patients felt less exhausted and fatigued than under medication 2, but likewise anxiety and depression increased in the course of the operating day. Group 4 emerged as the last effective premedication both with regard to sleep during the previous night and the conditions of the day of the operation itself.
mesh_terms: D000328:Adult; D000647:Amnesia / Q000139:chemically induced; D014151:Anti-Anxiety Agents; D001007:Anxiety / Q000517:prevention & control; D001569:Benzodiazepines; D003863:Depression / Q000517:prevention & control; D004644:Emotions / Q000187:drug effects*; D005445:Flunitrazepam / Q000494:pharmacology; D006801:Humans; D006993:Hypnotics and Sedatives; D008140:Lorazepam / Q000031:analogs & derivatives / Q000494:pharmacology; D008614:Meperidine / Q000494:pharmacology; D008875:Middle Aged; D011300:Preoperative Care; D011398:Promethazine / Q000494:pharmacology; D011594:Psychometrics
chemical_list: D014151:Anti-Anxiety Agents; D006993:Hypnotics and Sedatives; D001569:Benzodiazepines; D005445:Flunitrazepam; D008614:Meperidine; D011398:Promethazine; C023842:lormetazepam; D008140:Lorazepam
vernacular_title: Praemedikation mit Flunitrazepam, Lormetazepam oder Pethidin-Promethazin. Psychometrische Untersuchung der subjektiven Befindlichkeit.