title: [Basic and clinical studies of T-1982 (cefbuperazone) in the field of obstetrics and gynecology].
abstract: T-1982 (cefbuperazone), a new cephamycin antibiotic, was basically and clinically studied in the field of obstetrics and gynecology. The following results were obtained. The pelvic dead space exudate and serum levels of T-1982 were measured in patients with radical hysterectomy with pelvic lymphadenectomy for uterine cervical cancer after 1 hour drip infusion of 1 g. At the end of infusion, the serum level was 87.2 micrograms/ml on average and thereafter declined rapidly. The pelvic dead space exudate level attained the peak of 25.1 micrograms/ml at 2 hours and thereafter declined gradually but was 3.2 micrograms/ml even at 8 hours after infusion. A total of 10 cases comprising 1 with intrauterine infection, 2 with pelveoperitonitis, 2 with adnexitis and 5 with external genital organ infection were intravenously treated with T-1982 at a dose of 1 g twice daily for 5-7 days. The clinical results were excellent in 1 case, good in 8 cases and poor in 1 case. Eruption and elevated GOT and GPT were noted in 1 case.
mesh_terms: D000328:Adult; D002513:Cephamycins / Q000378:metabolism* / Q000627:therapeutic use; D004716:Endometritis / Q000188:drug therapy; D005122:Exudates and Transudates / Q000032:analysis; D005260:Female; D006801:Humans; D008875:Middle Aged; D000292:Pelvic Inflammatory Disease / Q000188:drug therapy; D010388:Pelvis
chemical_list: D002513:Cephamycins; C035978:cefbuperazone