Unusual clinical courses of adult T-cell leukemia in siblings.
Two siblings who developed adult T-cell leukemia (ATL) with unusual clinical courses are presented. The brother showed spontaneous remissions at the beginning stage of the disease of 6 years' duration, and the sister remains free of complaints for 6 years without chemotherapy. The patients and 2 of 12 healthy members of their family examined had serum antibodies against ATL-associated antigens (ATLA). The expression of ATLA was observed in the cultured lymphocytes from the patients and one of the family members.
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D002469:Cell Separation; D005260:Female; D006801:Humans; D007938:Leukemia / Q000235:genetics* / Q000276:immunology / Q000473:pathology; D008297:Male; D008562:Membrane Glycoproteins; D008875:Middle Aged; D010375:Pedigree; D013601:T-Lymphocytes / Q000276:immunology* / Q000473:pathology
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D008562:Membrane Glycoproteins; C028388:thymus-leukemia antigens