Aminooxyacetic acid provides transient protection against seizures induced by hyperbaric oxygen.
In an attempt to demonstrate a protective effect against convulsions induced by hyperbaric oxygen (OHP), aminooxyacetic acid (AOAA at 2.5 mg/kg) was administered subcutaneously to 60 white leghorn cockerels (aged 21-28 days) at periods of 1-72 h before exposure to OHP. A transient protection was noted 1-8 h after administration of the AOAA. This took the form of a 51-67% increase in the latent period before OHP induced convulsions began. By 12 h after injection, the protective effect had disappeared. Thereafter a phase of increased susceptibility to hyperbaric oxygen commenced. This phase lasted for at least a further 60 h.
D000085:Acetates / Q000627:therapeutic use*; D000625:Aminooxyacetic Acid / Q000627:therapeutic use*; D000818:Animals; D000927:Anticonvulsants; D001274:Atmospheric Pressure; D001923:Brain Chemistry / Q000187:drug effects; D002645:Chickens; D008297:Male; D010100:Oxygen; D012640:Seizures / Q000209:etiology / Q000517:prevention & control*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D000085:Acetates; D000927:Anticonvulsants; D000625:Aminooxyacetic Acid; D005680:gamma-Aminobutyric Acid; D010100:Oxygen