title: Serum protein pattern in normal pregnancy with special reference to acute-phase reactants.
abstract: The concentrations of acute-phase protein reactants, total protein, albumin and globulin fractions were measured throughout normal pregnancy in 27 women. alpha 1-Antitrypsin and caeruloplasmin concentrations increased gradually to reach their highest levels in the third trimester. Orosomucoid and haptoglobin showed similar patterns: higher levels in the first and third trimester with a decline around 24 weeks gestation. C-Reactive protein showed levels similar to those of non-pregnant healthy individuals (less than 5 mg/l) throughout pregnancy. alpha 1-, alpha 2- and beta-Globulin concentrations increased from the first trimester towards term. gamma-Globulin concentration changed little during gestation. The data obtained provide reference ranges for serum proteins in healthy pregnancy.
mesh_terms: D000328:Adult; D001798:Blood Proteins / Q000032:analysis*; D002097:C-Reactive Protein / Q000032:analysis; D002570:Ceruloplasmin / Q000032:analysis; D005260:Female; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D009961:Orosomucoid / Q000032:analysis; D011247:Pregnancy; D012016:Reference Values; D012709:Serum Albumin / Q000032:analysis; D012712:Serum Globulins / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D001798:Blood Proteins; D006242:Haptoglobins; D009961:Orosomucoid; D012709:Serum Albumin; D012712:Serum Globulins; D000515:alpha 1-Antitrypsin; D002097:C-Reactive Protein; D002570:Ceruloplasmin