Hypotelorism in trisomy 1-producing mice.
Trisomy 1 embryos in mice are smaller in all dimensions, showing a developmental retardation as compared with euploid mice. Very rarely the trisomic embryos develop a typical hypotelorism with holoprosencephalon and missing olfactory nerves. Corneal distances, angles between the optic nerves and further microscopic examination showed no intermediate forms between the trisomy 1 embryos and the rare trisomy 1 embryo with hypotelorism. There seems to be a threshold, beyond which the major developmental derangement occurred. This is an experimental model showing parallels to the occasional varying phenotypes in human trisomies.
D000818:Animals; D003394:Craniofacial Dysostosis / Q000235:genetics*; D051379:Mice; D008817:Mice, Mutant Strains; D009832:Olfactory Nerve / Q000002:abnormalities; D009900:Optic Nerve / Q000002:abnormalities; D010641:Phenotype; D014314:Trisomy