Transient, selective factor X deficiency and acute liver failure following chest infection treated with erythromycin BP.
A 57-year-old man developed symptoms of a respiratory tract infection which was treated with erythromycin BP. He subsequently went into acute liver failure. Investigation of a very prolonged prothrombin time revealed a marked, selective factor X deficiency (1% of normal activity). He later recovered virtually normal liver function and completely normal factor X activity.
D056486:Chemical and Drug Induced Liver Injury; D004917:Erythromycin / Q000009:adverse effects*; D005171:Factor X Deficiency / Q000209:etiology*; D006801:Humans; D007020:Hypoprothrombinemias / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D012141:Respiratory Tract Infections / Q000188:drug therapy*
D004917:Erythromycin