[Immune complexes in neoplastic diseases and autoimmune processes].
The level and possible pathologic relevance of circulating immune complexes (ICs) were investigated by polyethylene glycol precipitation method in sera of 109 untreated cancer patients (melanoblastoma, lung and breast cancer) and 118 patients with various immune complex diseases (collagenosis, nephropathia, vasculitis and immune hemocytopenia). The highest level of ICs was established in all patients with melanoblastoma. The raised concentration of ICs was registered in patients with malignancies of lung and breast (42 and 44%, respectively). A relationship between increased level of ICs and the rate of its growth in breast cancer patients, on the one hand, and clinical stage of the disease, on the other, was shown. The pathogenic effects of ICs in malignancies and immune complex diseases are compared.
D000936:Antigen-Antibody Complex / Q000032:analysis*; D001327:Autoimmune Diseases / Q000276:immunology*; D001943:Breast Neoplasms / Q000276:immunology / Q000473:pathology; D003095:Collagen Diseases / Q000276:immunology; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology; D008297:Male; D008545:Melanoma / Q000276:immunology; D008875:Middle Aged; D009369:Neoplasms / Q000276:immunology*; D012878:Skin Neoplasms / Q000276:immunology
D000936:Antigen-Antibody Complex
Immunnye kompleksy pri opukholevykh zabolevaniiakh i autoimmunnykh protsessakh.