The opposite effects of central and peripheral vasoactive intestinal polypeptide on blood pressure in rats.
In conscious normotensive rats catheterized for continuous recording of blood pressure, intracerebroventricular injections of vasoactive intestinal polypeptide (VIP) produced pressor responses in contrast to depressor effects when given intravenously. The pressor effect was not mediated by angiotensin II since pretreatment with an angiotensin antagonist failed to block the response. These findings show that there are separate mechanisms for central versus peripheral effects of VIP.
D000804:Angiotensin II / Q000502:physiology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014660:Vasoactive Intestinal Peptide / Q000008:administration & dosage* / Q000494:pharmacology
D000804:Angiotensin II; D014660:Vasoactive Intestinal Peptide