Atrophic gastritis induced by injection of xenogeneic stomach antigen in mice.
Wistar/Furth rat stomach antigen emulsified with an equal volume of Freund's complete adjuvant was subcutaneously injected into several strains of mice. Atrophy of the glandular stomach was produced in A/HeJ mice, but not in CF1, C57BL/6J or ICR/JCL mice. Atrophy of the glandular stomach was found to become most severe in 4-month-old animals. In 6-month-old mice and 12-month-old mice, atrophy was not observed. The increase in atrophy corresponds with the dose of antigen.
D000367:Age Factors; D000818:Animals; D000941:Antigens / Q000008:administration & dosage / Q000235:genetics; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D005756:Gastritis / Q000473:pathology*; D005757:Gastritis, Atrophic / Q000209:etiology / Q000473:pathology*; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000276:immunology / Q000473:pathology
D000941:Antigens