Immunoglobulin synthesis in hairy cell leukaemia. Ultrastructural immunocytochemical study of 3 cases.
3 cases of hairy cell leukaemia were studied with ultrastructural immunocytochemical methods using an anti human Ig HRPO-Fab fragment. Ig were detected on the cell surface, in the perinuclear cisterna and endoplasmic reticulum of hairy cells. Evidence of Ig in these sites demonstrates a B-lymphoid differentiation of the leukaemic cells.
D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology; D004721:Endoplasmic Reticulum / Q000276:immunology; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000096:biosynthesis*; D007943:Leukemia, Hairy Cell / Q000276:immunology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D011947:Receptors, Antigen, B-Cell / Q000096:biosynthesis
D007136:Immunoglobulins; D011947:Receptors, Antigen, B-Cell