Evidence for a new lymphocyte-stimulating determinant (Lsd) detected by alloreactive T cell lines.
Three alloreactive T cell clones are described which reveal a new lymphocyte-stimulating determinant (Lsd) controlled by a gene on chromosome 1 of the mouse but different from and possibly centromeric to Mls. Two clones were originally isolated as anti-H-2b-specific and showed and retained cross-reactivity to Lsd (clone OD3, BALB/c anti-C57BL/6; clone KB37, B10.BR anti-C57BL/10). The third clone (BD7, C57BL/6 anti-CBA/J) was probably originally directed against Lsd. So far, Lsd is only characterized by stimulation of T cell proliferation, and its physiological function is not yet known.
D000818:Animals; D002460:Cell Line; D003429:Cross Reactions; D005260:Female; D006649:Histocompatibility Antigens / Q000032:analysis* / Q000235:genetics; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D008814:Mice, Inbred NZB; D013601:T-Lymphocytes / Q000276:immunology*
D006649:Histocompatibility Antigens