Effect of vitamin C on acute paracetamol poisoning.
The effects of vitamin C on acute paracetamol poisoning were studied in mice. Given orally at 50, 100 or 200 mg/kg, either simultaneously or 2 h after the oral administration of 875 mg/kg of paracetamol, vitamin C did not cause any decrease in the mortality rate. In similar conditions in previous experiments methionine and cysteine were shown to be very effective antidotes.
D000082:Acetaminophen / Q000506:poisoning*; D000208:Acute Disease; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D000082:Acetaminophen; D001205:Ascorbic Acid