[Inhibition of lipid peroxidation by derivatives of o-benzoquinone in liver microsomes].
It was found that o-benzquinone derivatives inhibit lipid peroxidation in rat liver microsomes. This is not due to the ability of these compounds to shunt electron transport pathways in microsomes. In the presence of reducing agents the o-benzquinone derivatives exist in two forms, i. e. oxidized (quinone) and reduced (diphenol) ones. It was shown that the diphenol form capable of interacting with free radicals exerts antioxidant effects. The experimental data suggest that these radicals are lipid peroxidation inducers. Unlike the free radical scavengers of a phenolic type, each o-benzquinone molecule can become involved in manyfold inhibition of lipid peroxidation.
D000818:Animals; D016227:Benzoquinones; D007700:Kinetics; D008054:Lipid Peroxides / Q000378:metabolism*; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D010084:Oxidation-Reduction; D011809:Quinones / Q000494:pharmacology*; D051381:Rats; D013329:Structure-Activity Relationship
D016227:Benzoquinones; D008054:Lipid Peroxides; D011809:Quinones; C025225:2-benzoquinone
Ingibirovanie proizvodnymi o-benzokhinona perekisnogo okisleniia lipidov v mikrosomakh pecheni.