Lack of evidence for polymorphism in metoprolol metabolism.
The claim for polymorphism in the metabolism of metoprolol is based on a logical fallacy. A frequency distribution of metoprolol AUC data is presented and, although highly skewed, no evidence of more than a single population is apparent. Plasma and urine metoprolol and metabolite data are also presented to support this.
D000070:Acebutolol / Q000097:blood; D000328:Adult; D001711:Biotransformation; D006207:Half-Life; D006801:Humans; D008790:Metoprolol / Q000031:analogs & derivatives / Q000378:metabolism*; D011110:Polymorphism, Genetic
C029504:alpha-hydroxymetoprolol; D000070:Acebutolol; D008790:Metoprolol