Apparent gastrointestinal origin of cis-4-hydroxycyclohexanecarboxylic acid.
We identified by gas chromatography-mass spectrometry the unusual substance cis-4-hydroxycyclohexanecarboxylic acid (4-HCH) in the urine of a child. Urinary excretion of 4-HCH and intestinal bacteria were both suppressed by neomycin treatment. We propose that 4-HCH is a by-product of bacterial metabolism.
D001419:Bacteria / Q000378:metabolism*; D002849:Chromatography, Gas; D003509:Cyclohexanecarboxylic Acids / Q000652:urine*; D004064:Digestive System / Q000382:microbiology*; D005260:Female; D006801:Humans; D007223:Infant; D009355:Neomycin / Q000627:therapeutic use; D013237:Stereoisomerism
D003509:Cyclohexanecarboxylic Acids; D009355:Neomycin