Positron CT imaging using a high resolution PCT device (Positologica-I), 11CO, 13NH3, and 18FDG in clinical evaluation of cerebrovascular diseases.
Positron computed tomography (PCT) was performed in 3 normal volunteers and 21 patients with cerebrovascular diseases using a high resolution PCT device 'Positologica-I' and three tracers 11CO, 13NH3, and 18FDG. Relatively early lesions showed various accumulation patterns, and metabolism and perfusion mismatches were clearly shown by this measurement. One type of mismatch is luxury perfusion which had a slight increase of blood volume. Another type of uncoupling is misery perfusion. Remote effects of ischemic lesions also appeared on PCT with 18FDG and 13NH3. From our clinical results, the PCT method with a high resolution device and radiopharmaceuticals such as 11CO, 13NH3, and 18FDG is very useful in the assessment of cerebrovascular diseases and in defining circulatory dysfunction in man.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000641:Ammonia; D002248:Carbon Monoxide; D002250:Carbon Radioisotopes; D002544:Cerebral Infarction / Q000000981:diagnostic imaging; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging*; D003847:Deoxyglucose / Q000031:analogs & derivatives; D005461:Fluorine; D019788:Fluorodeoxyglucose F18; D006423:Hemianopsia / Q000000981:diagnostic imaging; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000000981:diagnostic imaging; D002546:Ischemic Attack, Transient / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009590:Nitrogen Radioisotopes; D011868:Radioisotopes; D014055:Tomography, Emission-Computed / Q000295:instrumentation
D002250:Carbon Radioisotopes; D009590:Nitrogen Radioisotopes; D011868:Radioisotopes; D019788:Fluorodeoxyglucose F18; D005461:Fluorine; D000641:Ammonia; D002248:Carbon Monoxide; D003847:Deoxyglucose