[Iron chelate treatment of hereditary sideroblastic anemia complicated by hemochromatosis].
In a child with sideroblastic anemia complicated with hemochromatosis, iron overload was successfully treated with slow subcutaneous perfusion of deferoxamine. A 28 month-treatment resulted in the inversion of iron balance, which became negative, and the normalization of serum ferritin and abdominal CT scan. These results indicate that deferoxamine perfusion 12/24 hrs is able to restrict or even to remove the iron overload, previously responsible for hemochromatosis, a factor of mortality in this disease.
D000293:Adolescent; D000756:Anemia, Sideroblastic / Q000150:complications / Q000188:drug therapy* / Q000235:genetics; D003676:Deferoxamine / Q000627:therapeutic use; D005293:Ferritins / Q000097:blood; D006432:Hemochromatosis / Q000209:etiology*; D006801:Humans; D007502:Iron Chelating Agents / Q000627:therapeutic use*; D008297:Male
D007502:Iron Chelating Agents; D005293:Ferritins; D003676:Deferoxamine
Traitement chélateur du fer dans l'anémie sidéroblastique héréditaire compliquée d'hémochromatose.