Effects of subminimal inhibitory concentrations of aminoglycosides on the penicillinase production of Staphylococcus aureus.
The effects of subminimal inhibitory concentrations of kanamycin, amikacin and gentamicin on the production of penicillinase by Staphylococcus aureus were tested on 12 penicillin-resistant strains. Of the 36 experiments performed, 16 (44%) displayed an increase and 9 (25%) produced a decrease in the penicillinase activity of the strains. These effects were observed at concentrations ranging from 1:2 to 1:2,048 of the respective minimal inhibitory concentration, irrespective of the susceptibility of the strain to the aminoglycoside drug.
D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D010405:Penicillinase / Q000096:biosynthesis*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000201:enzymology; D001618:beta-Lactamases / Q000096:biosynthesis*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D010405:Penicillinase; D001618:beta-Lactamases