Differentiation of ovine immature B cells upon exposure to phorbol myristate acetate.
Immature B cells obtained from the ileal Peyer's patches ( IPPs ) of sheep, upon exposure to phorbol myristate acetate (PMA), expressed 20-30 times more sIgM per cell than nonstimulated IPP cells, and the sIgM level was the same as that of peripheral B cells. The exposure of IPP cells to PMA also induced IgM secretion. Macrophages were not required for the terminal differentiation of IPP cells in vitro.
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D002454:Cell Differentiation / Q000187:drug effects; D010704:Phorbols / Q000494:pharmacology*; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D012756:Sheep; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D010704:Phorbols; D011947:Receptors, Antigen, B-Cell; D013755:Tetradecanoylphorbol Acetate