title: Structure of mouse kallikrein gene family suggests a role in specific processing of biologically active peptides.
abstract: The glandular kallikrein gene family comprises 25-30 highly homologous genes that encode specific proteases involved in the processing of biologically active peptides. In the mouse all the members of this family are closely linked on chromosome 7. The 9.5-kilobase nucleotide sequence of a mouse genomic clone contains one complete kallikrein gene (mGK-1), which is expressed in the male mouse submaxillary gland, and the 3' end of another (mGK-2). Differences in the coding potential of these genes and the amino acid sequences of other known kallikreins seem to be functionally related to the substrate specificity of the different enzymes.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004815:Epidermal Growth Factor / Q000235:genetics; D007610:Kallikreins / Q000235:genetics* / Q000502:physiology; D051379:Mice; D009414:Nerve Growth Factors / Q000235:genetics; D010452:Peptide Biosynthesis; D011498:Protein Precursors / Q000378:metabolism
chemical_list: D009414:Nerve Growth Factors; D011498:Protein Precursors; D004815:Epidermal Growth Factor; D007610:Kallikreins