[Silatranes as stimulators of the development of granulation tissue].
Experiments on rats were made to study the effect of I-(chloromethyl) silatrane and I- (ethoxy) silatrane and that of triethanolamine and chloromethyl triethoxysilane on biochemical parameters of granular-fibrous tissue. The preparations were applied to a wound defect in the form of liniments. Silatranes were found to stimulate proliferation of the cells and to increase their biosynthetic activity, to favour accumulation of collagen and non-collagenic proteins, and reduction of the inflammatory phenomena. The silicon-containing fragment of the silatrane molecule chloromethyl triethoxysilane produced an analogous but less marked action. Triethanolamine containing no silicon was found to be as less active. These data indicate that silicon entering the silatrane grouping is of great importance for the occurrence of its biological activity.
D000818:Animals; D001643:Bridged Bicyclo Compounds / Q000008:administration & dosage*; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds / Q000008:administration & dosage*; D004983:Ethanolamines / Q000008:administration & dosage; D006097:Granulation Tissue / Q000187:drug effects*; D008038:Liniments; D017646:Organosilicon Compounds; D051381:Rats; D012825:Silicon / Q000008:administration & dosage*; D013268:Stimulation, Chemical
D001643:Bridged Bicyclo Compounds; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds; D004983:Ethanolamines; D008038:Liniments; D017646:Organosilicon Compounds; C015503:silatrane; C033818:1-(chloromethyl)silatrane; C009546:triethanolamine; D012825:Silicon
Silatrany kak stimuliatory razvitiia granuliatsionnoĭ tkani.