title: Role of glucocorticoids on the maturation of brush border enzymes in fetal rat gut endoderm.
abstract: Heterospecific recombinants between fatal rat intestinal endoderm and chick mesenchyme, and also undissociated fetal rat intestine, were submitted to different hormonal environments. The present study shows that exogenously-supplied dexamethasone in organ culture, like endogenous hormones provided by the adult rat (grafting experiments) led to similar qualitative and quantitative results, i.e., a 9-fold stimulation of maltase and a precocious induction of sucrase activity in comparison with an hormonal conditions.
mesh_terms: D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D004707:Endoderm / Q000187:drug effects / Q000648:ultrastructure*; D005260:Female; D008871:Microvilli / Q000187:drug effects / Q000201:enzymology; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D003907:Dexamethasone