Action of ammonium meta vanadate on hepatic enzymes in vitro.
In an in vitro study with rat liver, ammonium meta vanadate (NH4VO3) was found to inhibit microsomal ketamine N-demethylation, lipid peroxidation, and hydrogen peroxide formation; to have no effects on 4-methylaminoantipyrine N-demethylation and on glucuronyltransferase I activity, and to enhance glucuronyltransferase II. Mitochondrial succinate dehydrogenase and cytochrome c reductase were inhibited but cytochrome oxidase activity was enhanced by ammonium vanadate. Ammonium meta vanadate increased malate dehydrogenase activity but had no effect on glutamate, lactate, glycerophosphate, isocitrate, glucose-6-phosphate, and 6-phosphogluconate dehydrogenases.
D000818:Animals; D003600:Cytosol / Q000201:enzymology; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008862:Microsomes, Liver / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D051381:Rats; D014639:Vanadium / Q000494:pharmacology*
D014639:Vanadium