Clinical effect of human-fibroblast-derived (beta) interferon in treatment of adeno-virus epidemic keratoconjunctivitis and its complication.
The clinical studies reviewed here indicated the usefulness of topical application of Human-fibroblast-derived (Beta) interferon (HulFN-B) in treatment of Adeno-8 Epidemic-keratoconjunctivitis. A week treatment with 2-5 X 10(5) reference units daily doses, starting early as possible, reduced the length of the disease from 22 day to a week, and almost totally prevented the appearance of subepithelial keratitis which occurred in 57% of the control group. Possibly interferon should be given also prophylactically to individuals exposed to contagion. Our results encourage further investigation on the Hul FN-B use as a drug for treatment and prevention of viral infection.
D000287:Administration, Topical; D004196:Disease Outbreaks / Q000453:epidemiology; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D007557:Israel; D007634:Keratitis / Q000517:prevention & control; D007637:Keratoconjunctivitis / Q000175:diagnosis / Q000188:drug therapy* / Q000453:epidemiology; D008297:Male
D007370:Interferon Type I