Increase of HLA-"DRw6" in patients with juvenile chronic arthritis.
In 43 patients with pauciarticular and 26 patients with polyarticular juvenile chronic arthritis (JCA), an increased frequency was found for HLA-B27 (36%) in male patients with onset of the disease over 9 years of age. The antigen "DRw6" was observed in high frequency (average 57%) in all subtypes of the disease. Indications for increased frequencies were obtained for DR3 in male JCA (40%) and DR5 (42%) in female JCA patients.
D001171:Arthritis, Juvenile / Q000276:immunology*; D005260:Female; D005787:Gene Frequency; D006680:HLA Antigens / Q000032:analysis; D015796:HLA-B27 Antigen; D006684:HLA-DR Antigens; D015808:HLA-DR6 Antigen; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D008297:Male
D006680:HLA Antigens; D015796:HLA-B27 Antigen; D006684:HLA-DR Antigens; D015808:HLA-DR6 Antigen; D000949:Histocompatibility Antigens Class II