[Increased frequency of sister chromatid exchange in persons occupationally exposed to ethylene oxide].
Mutagenic effects of ethylene oxide have been demonstrated by short-term testing in vitro and in vivo in several organisms. Its oncogenic activity for man has been suspected and recently supported by experiments in mice. Exposure can occur during ethylene oxide gas sterilization of medical materials. We have tested effects on chromosomes by estimating sister chromatids exchange (SCE) frequency. Our results, reported here, show that exposure to this substance during work is followed by a very highly significant increase of SCE frequency as compared with controls. Thus, the SCE test may, under particular conditions, represent a reliable test for exposure to certain toxic agents.
D000328:Adult; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008231:Lymphopenia / Q000139:chemically induced / Q000235:genetics; D008297:Male; D008875:Middle Aged; D010087:Oxides / Q000009:adverse effects*; D010564:Personnel, Hospital; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D012907:Smoking
D010087:Oxides
Augmentation du taux d'échanges entre chromatides-soeurs chez des personnes exposées professionnellement à l'oxyde d'éthylène.