Circulating immune complexes and platelet thromboxane synthesis in patients with insulin-dependent (type I) diabetes mellitus.
Platelets from diabetic subjects with circulating immune complexes (CIC) synthesized greater amounts of thromboxane than did platelets from CIC-negative patients or controls. In view of the known action of CIC on platelet function, a relationship between these two factors may be suggested in the initiation and progression of microangiopathy in diabetes.
D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D000936:Antigen-Antibody Complex / Q000032:analysis*; D001792:Blood Platelets / Q000201:enzymology*; D002648:Child; D003176:Complement C3 / Q000276:immunology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000201:enzymology / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D007330:Insulin Antibodies / Q000032:analysis; D008297:Male; D013929:Thromboxane B2 / Q000096:biosynthesis*; D013931:Thromboxanes / Q000096:biosynthesis*
D000888:Antibodies, Anti-Idiotypic; D000936:Antigen-Antibody Complex; D003176:Complement C3; D007074:Immunoglobulin G; D007330:Insulin Antibodies; D013931:Thromboxanes; D013929:Thromboxane B2