Naloxone administration in obsessive-compulsive disorder: report of two cases.
Two patients with obsessive-compulsive disorder experienced an exacerbation of chronic obsessional doubt after double-blind, placebo-controlled administration of naloxone. Endogenous opiates may be involved in the pathogenesis of this symptom.
D000208:Acute Disease; D000328:Adult; D004311:Double-Blind Method; D004723:Endorphins / Q000037:antagonists & inhibitors / Q000502:physiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology*; D009771:Obsessive-Compulsive Disorder / Q000503:physiopathology* / Q000523:psychology
D004723:Endorphins; D009270:Naloxone