Effects of norepinephrine and serotonin uptake inhibitors on the schedule-controlled behavior of the pigeon.
The effects of nortriptyline, amitriptyline, desipramine, chlorimipramine, protriptyline, doxepin, nisoxetine, fluoxetine and iprindole were determined on responding by pigeons under a multiple fixed-ratio 30-response, fixed-interval 10-minute schedule of grain presentation. Those drugs which have been shown to block uptake of norepinephrine decreased fixed-interval quarter-life values. Those which are considered most selective as norepinephrine uptake inhibitors also increased overall fixed-interval responding. These increases in fixed-interval responding, both on local and overall rates, in pigeons appear to be due to the actions of these drugs to inhibit uptake of norepinephrine rather than to other actions.
D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D002997:Clomipramine / Q000494:pharmacology; D010856:Columbidae; D003216:Conditioning, Operant / Q000187:drug effects*; D003891:Desipramine / Q000494:pharmacology; D004316:Doxepin / Q000494:pharmacology; D005473:Fluoxetine / Q000031:analogs & derivatives / Q000494:pharmacology; D007488:Iprindole / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D011530:Protriptyline / Q000494:pharmacology; D012055:Reinforcement Schedule; D012702:Serotonin Antagonists / Q000494:pharmacology*
D000929:Antidepressive Agents, Tricyclic; D012702:Serotonin Antagonists; D005473:Fluoxetine; D004316:Doxepin; C011386:nisoxetine; D000639:Amitriptyline; D011530:Protriptyline; D007488:Iprindole; D002997:Clomipramine; D003891:Desipramine; D009638:Norepinephrine