Influence of 13-cis retinoic acid and of arotinoid on the cytochrome P-450 system in rat liver.
Female Wistar rats were treated with either 13-cis retinoic acid or arotinoidethyl ester in a dose comparable to those used in humans over different periods up to 28 days. In the liver of the animals the following parameters were estimated: microsomal protein content, cytochrome P-450 content, and cytochrome P-450-dependent activities of enzymes such as aminopyrine-N-demethylase, arylhydrocarbon hydroxylase, and 7-ethoxycoumarin deethylase. Only a transitory increase of the aminopyrine-N-demethylase after 3 days of treatment could be demonstrated. From this animal study, there is no evidence of interactions between retinoids and drug-metabolizing monooxygenases, e.g., the metabolism of contraceptive active steroids.
D015660:7-Alkoxycoumarin O-Dealkylase; D000633:Aminopyrine N-Demethylase / Q000096:biosynthesis; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis; D001565:Benzoates / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis*; D004790:Enzyme Induction; D005260:Female; D015474:Isotretinoin; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D010105:Oxygenases / Q000096:biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains; D012176:Retinoids; D014212:Tretinoin / Q000494:pharmacology*
D001565:Benzoates; D012176:Retinoids; D014212:Tretinoin; C034814:ethyl-p-((E)-2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthyl)-1-propenyl)benzoic acid; D003577:Cytochrome P-450 Enzyme System; D010105:Oxygenases; D015660:7-Alkoxycoumarin O-Dealkylase; D001189:Aryl Hydrocarbon Hydroxylases; D000633:Aminopyrine N-Demethylase; D015474:Isotretinoin