title: Behavioral disease in rats caused by immunopathological responses to persistent borna virus in the brain.
abstract: Borna virus replicated persistently in the brains of rats, causing frenzied and apathetic behavioral states in sequence but no mortality. The transient frenzied behavior was caused by an immune-mediated, cytolytic, encephalitic response that was unexpectedly self-limiting. Cessation of active pathological processes coincided with the onset of the passive phase of the disease. This study thus demonstrates suppression of virus-specific inflammation despite continuous viral replication and describes a new mechanism by which chronic encephalitis may become established.
mesh_terms: D000818:Animals; D001522:Behavior, Animal; D001890:Borna Disease / Q000276:immunology / Q000473:pathology* / Q000523:psychology; D001921:Brain / Q000473:pathology; D006801:Humans; D007249:Inflammation / Q000473:pathology; D008032:Limbic System / Q000473:pathology; D051379:Mice; D009043:Motor Activity; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000382:microbiology