Intrathecal vincristine. Report of a fatal case despite CNS washout.
The clinical course of a two-year-old girl with acute lymphocytic leukemia (ALL) who inadvertently received intrathecal vincristine is presented. Despite aggressive treatment with parenteral folinic acid and extensive central nervous system washout, the outcome was fatal. The pharmacologic aspects of vincristine and folinic acid that may explain why treatment was unsuccessful, are reviewed.
D002490:Central Nervous System / Q000187:drug effects*; D005260:Female; D006801:Humans; D007223:Infant; D007278:Injections, Spinal / Q000009:adverse effects; D002955:Leucovorin / Q000627:therapeutic use; D007945:Leukemia, Lymphoid / Q000188:drug therapy* / Q000401:mortality; D008508:Medication Errors; D014750:Vincristine / Q000008:administration & dosage / Q000009:adverse effects*
D014750:Vincristine; D002955:Leucovorin