title: [Study of HLA antigens A and B and their cross reactions in B27-negative ankylosing spondylarthritis].
abstract: In an attempt to find common immunogenetic features in B27+ and B27- ankylosing spondylitis patients, the B7 cross reactant antigens (BW22, B27, B40, B12, B13) were systematically tested by a lymphocytotoxicity method in 43 patients suffering from ankylosing spondylitis according to the Rome criteria. These included 25 caucasian patients (20 B27+, 5 B27-), 15 north african patients (11 B27+, 4 B27-) and 3 west indian mulattos (all B27-). The frequency of the B7 cross reactant antigens, when compared to controls, was not increased in the B27- patients as a whole, nor in any of the 3 populations studied. Our negative results are in agreement with those of similar published studies in homogeneous populations. They do not support the hypothesis of a direct involvement of HLA B antigens as cofactors favouring ankylosing spondylitis.
mesh_terms: D003429:Cross Reactions; D006680:HLA Antigens / Q000276:immunology*; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015796:HLA-B27 Antigen; D006801:Humans; D044469:Racial Groups; D013167:Spondylitis, Ankylosing / Q000276:immunology*
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015796:HLA-B27 Antigen
vernacular_title: Etude des antigènes HLA A et B et de leurs réactions croisées dans la spondylarthrite ankylosante B27 négative.