Control of triglyceride synthesis by the intracellular level of long-chain acyl coenzyme A for lipid synthesis.
Candida lipolytica mutants defective in acyl coenzyme A synthetase I synthesized triglyceride to a markedly less extent than did the wild-type yeast, when grown on oleic acid. The synthesis of triglyceride was controlled by the level of long-chain acyl coenzyme A available for lipid synthesis, whereas the synthesis of phospholipids was hardly affected.
D000214:Acyl Coenzyme A / Q000378:metabolism*; D002175:Candida / Q000235:genetics / Q000378:metabolism*; D003066:Coenzyme A Ligases / Q000378:metabolism; D009154:Mutation; D010743:Phospholipids / Q000096:biosynthesis; D014280:Triglycerides / Q000096:biosynthesis*
D000214:Acyl Coenzyme A; D010743:Phospholipids; D014280:Triglycerides; D003066:Coenzyme A Ligases