Kinetics of some types of lymphocytes in peripheral blood of patients with bronchial asthma.
Atopic (house dust) and infectious-allergic forms of bronchial asthma are accompanied by relative and absolute increases in the cortisol-resistant lymphocyte fraction. This increase is higher in infectious allergic asthma and is especially marked in patients, taking cortico-steroid hormones. At the same time a decrease of the relative content of T-lymphocytes from their normal quantity per unit of blood volume was revealed. In patients, taking corticosteroids. This decrease of the relative content of T-lymphocytes was combined with their absolute increase. All patients had a) relative and absolute decrease of the active part of T-lymphocytes (active E-RFC), the degree of which was connected with the stage and form of illness. b) redistribution in the T-population of lymphocytes towards an increase of the cortisol-resistant subpopulation of T-cells and especially in patients taking corticosteroids. Increases in the cortisol-resistant subpopulation of T-lymphocytes in patients with infectious-allergic asthma and in patients with atopic asthma during remission are accompanied by an increase in the cortisol-resistant part of active T-lymphocytes (active E-RFC), both in patients taking or not taking corticosteroids.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000328:Adult; D001249:Asthma / Q000188:drug therapy / Q000209:etiology / Q000276:immunology*; D003141:Communicable Diseases / Q000150:complications; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D006969:Hypersensitivity, Immediate / Q000150:complications; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology
D000305:Adrenal Cortex Hormones; D006854:Hydrocortisone