Endocardial fibroelastosis associated with fatal adriamycin (doxorubicin) cardiomyopathy during treatment of Ewing's sarcoma.
We report a case of fatal adriamycin cardiomyopathy in a 12-year-old boy treated for Ewing's sarcoma. At necropsy, in addition to the typical changes of advanced cardiotoxicity in the myocardium there was endocardial fibroelastosis, mainly affecting the left ventricle.
D009202:Cardiomyopathies / Q000139:chemically induced*; D002648:Child; D004317:Doxorubicin / Q000009:adverse effects* / Q000627:therapeutic use; D004695:Endocardial Fibroelastosis / Q000139:chemically induced*; D006801:Humans; D008297:Male; D012512:Sarcoma, Ewing / Q000188:drug therapy*
D004317:Doxorubicin