[Factors responsible for increasing the cytogenetic effectiveness of cyclophosphamide administered to irradiated animals. Cytogenetic effect of mutagens not requiring metabolic activation on bone marrow cells of irradiated rats].
The cytogenetic action of mutagens, that do not require metabolic activation (embichin and sarcolysine), and X-radiation on rat bone marrow was studied 1 month after preliminary irradiation with the dose of 4.25 Gy. The frequency of chromosome aberrations induced by the above-mentioned effects was the same as that in nonirradiated rats.
D000818:Animals; D001711:Biotransformation; D001853:Bone Marrow / Q000187:drug effects* / Q000528:radiation effects; D002869:Chromosome Aberrations; D003520:Cyclophosphamide / Q000494:pharmacology*; D008297:Male; D008466:Mechlorethamine / Q000494:pharmacology; D008558:Melphalan / Q000494:pharmacology; D009153:Mutagens; D011833:Radiation Injuries, Experimental / Q000235:genetics*; D051381:Rats
D009153:Mutagens; D008466:Mechlorethamine; D003520:Cyclophosphamide; D008558:Melphalan
Izuchenie prichin, obuslovlivaiushchikh usilenie tsitogeneticheskoĭ éffektivnosti tsiklofosfana pri vvedenii ego obluchennym zhivotnym. Issledovanie tsitogeneticheskogo deĭstviia mutagenov, ne trebuiushchikh metabolicheskoĭ aktivatsii, na kletki kostnogo mozga obluchennykh krys.