[Orciprenaline (Alupent) in resuscitation for circulatory arrest? Experimental comparison between orciprenaline and adrenaline in dogs].
This study compares CPR with orciprenaline (8 dogs), with epinephrine (11 dogs) and without any drug (8 dogs) in cardiac arrest caused by anoxia. Resuscitation was successful in all animals of the epinephrine group and in 2 of the orciprenaline group. Spontaneous circulation could not be restored in any of the control animals. There was no difference in the occurrence of ventricular fibrillation between the drug groups. No fibrillation occurred in the controls. On the other hand, the incidence of successful defibrillation was significantly higher with epinephrine. The superiority of epinephrine was due to its having effected a significantly higher diastolic pressure during cardiac massage. The diastolic pressure decreased after orciprenaline injection to such an extent that coronary underperfusion resulted with consequent rise of serum CPK. We conclude that the use of orciprenaline is contraindicated in cardiac arrest.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects; D003402:Creatine Kinase / Q000097:blood; D004285:Dogs; D004837:Epinephrine / Q000627:therapeutic use*; D006323:Heart Arrest / Q000188:drug therapy*; D009921:Metaproterenol / Q000627:therapeutic use*; D012151:Resuscitation / Q000379:methods*
D009921:Metaproterenol; D003402:Creatine Kinase; D004837:Epinephrine
Orciprenalin (Alupent) in der Reanimation nach Kreislaufstillstand? Experimenteller Vergleich zwischen Orciprenalin und Adrenalin an Hunden.