Selective sensitivity of malignant cells to adriamycin.
The relationship of Adriamycin sensitivity to oxygen utilization by the cell is unclear. We examined the oxygen uptake and Adriamycin sensitivity of seven human colon carcinoma cell lines under normal aerobic conditions. Adriamycin sensitivity was inversely related to oxygen consumption and lactate dehydrogenase-specific activity.
D002460:Cell Line; D003110:Colonic Neoplasms / Q000378:metabolism; D004317:Doxorubicin / Q000494:pharmacology*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D009369:Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*
D004317:Doxorubicin; D007770:L-Lactate Dehydrogenase