[Analysis and stability of atropine sulfate and scopolamine hydrobromide. 2. Quantitative determination of the alkaloid in its decomposition product; 79. contribution to problems concerning the use of plastic containers for liquid pharmaceuticals].
The authors describe a method which permits, after thin-layer chromatographic separation and elution by means of the Eluchrom apparatus, to determine the tropane alkaloids and apoatropine in the presence of their decomposition products using tropaeolin 00. The recommended method has proved to be superior to other elution variants with regard to accuracy and reproducibility. Detectable amounts (microgram/ml): atropine, 0.4-4.0; scopolamine, 1.2-7.2; apoatropine, 0.8-3,2.
D001285:Atropine / Q000032:analysis*; D004349:Drug Packaging; D004355:Drug Stability; D010969:Plastics; D012601:Scopolamine / Q000032:analysis*
D010969:Plastics; D001285:Atropine; D012601:Scopolamine
Zur Analytik und Stabilität von Atropinsulfat und Scopolaminhydrobromid. Teil 2: Quantitative Bestimmung der Alkaloide neben Zersetzungsprodukten; 79. Mitteilung: Beiträge zur Problematik des Einsatzes von Kunststoffbehältern für flüssige Arzneizubereitungen.