title: Compensatory hypertrophy of the soleus in tumor-bearing rats.
abstract: Compensatory hypertrophy of the rat soleus was compared between normal rats (N) and rats bearing a non-metastasizing mammary tumor (TB). Two weeks after the tumor inoculation, introduced subcutaneously on the midline of the upper back, the two groups of rats underwent unilateral tenotomy of the plantaris and gastrocnemius muscles to induce functional overload or compensatory hypertrophy of the soleus. One week later, the body weight (BW), wet muscle weights (MW), percent of Type I (slow-twitch) and Type II (fast-twitch) muscle fibers and contractile parameters of the isometric twitch (Pt) and tetanic (Po) tensions were evaluated. The TB animals did not show any signs of cancer cachexia. The sham-operated control soleus muscles of the two groups were similar in wet MW, maximum isometric Pt and Po. The latent period (LP), the contraction time (CT), the half relaxation time (HRT) and the number of Type I (slow-twitch) fibers were increased significantly. The hypertrophied muscles in the N and TB rats showed significant declines in the maximum isometric Pt, compared to their respective controls. These data suggest that the compensatory hypertrophy of muscle is expressed similarly in both the normal and tumor-bearing rats but that it interferes with the generation of isometric twitch tension in the muscle.
mesh_terms: D000222:Adaptation, Physiological; D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D001835:Body Weight; D005260:Female; D006984:Hypertrophy; D008325:Mammary Neoplasms, Experimental / Q000473:pathology*; D009119:Muscle Contraction; D009132:Muscles / Q000473:pathology*; D009929:Organ Size; D051381:Rats; D011917:Rats, Inbred Lew; D011919:Rats, Inbred Strains