Are lesions induced by ionizing radiation direct blocks to DNA chain elongation?
Ionizing radiation blocks DNA chain elongation in normal diploid fibroblasts but not in fibroblasts from patients with ataxia-telangiectasia, even though there are no differences in the damage induced between the two cell types. This difference suggests that radiation-induced lesions in DNA are not themselves blocks to chain elongation in ataxia cells and raises the possibility that in normal cells a mediator exists between DNA damage and chain termination.
D001260:Ataxia Telangiectasia / Q000235:genetics / Q000473:pathology; D004247:DNA / Q000096:biosynthesis / Q000528:radiation effects*; D005347:Fibroblasts / Q000528:radiation effects; D006801:Humans; D009690:Nucleic Acid Conformation / Q000528:radiation effects; D012093:Replicon / Q000528:radiation effects
D004247:DNA