Effect of dental amalgam and nickel alloys on T-lymphocytes: preliminary report.
Preliminary data suggest that dental amalgam and dental nickel alloys can adversely affect the quantity of T-lymphocytes. Human T-lymphocytes can recognize specific antigens, execute effector functions, and regulate the type and intensity of virtually all cellular and humoral immune responses. Normal immune function depends on a proper quantity, quality, and ratio of T-lymphocyte helper and suppressor subsets. Further research may determine the frequency and magnitude of T-lymphocyte reduction and alteration by dental materials.
D000328:Adult; D001672:Biocompatible Materials; D003722:Dental Alloys / Q000494:pharmacology*; D003723:Dental Amalgam / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008231:Lymphopenia / Q000209:etiology; D008297:Male; D009532:Nickel / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000166:cytology / Q000187:drug effects*
D001672:Biocompatible Materials; D003722:Dental Alloys; D009532:Nickel; D003723:Dental Amalgam