Cell mediated immunity in perennial allergic rhinitis.
The authors studied a group of 72 patients with perennial allergic rhinitis. The following parameters were determined: the distribution of T total and T active and B lymphoid populations, non-specific T suppressor activity induced by concanavalin-A, response indices to stimulation by phytohaemagglutinin and pokeweed mitogen and levels of serum IgE. Comparison with 100 healthy controls showed a diminution with respect to the T total lymphoid subpopulation (p less than 0.001) and the suppressor activity (p less than 0.001). There was no significant change regarding the T active and B values and the lymphoproliferative response to the phytohaemagglutinin and pokeweed mitogen. A correlation was seen between the IgE levels (elevated in 62.5% of patients) with the T suppressor activity which was statistically significant (p less than 0.01).
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000145:classification; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007073:Immunoglobulin E / Q000032:analysis; D008214:Lymphocytes / Q000145:classification; D008297:Male; D008875:Middle Aged; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology*; D013601:T-Lymphocytes / Q000145:classification
D007073:Immunoglobulin E