title: 1976 Hanford americium exposure incident: hematologic effects.
abstract: Hematologic evaluation of an individual with an initial systemic body burden of approximately 200 mu Ci 241Am revealed a significant (P less than 0.01) reduction of total leukocytes, neutrophils and lymphocytes. This effect on total leukocytes and neutrophils was evident approximately 30 days after exposure, appeared to stabilize at about 3 months after exposure, and remained at this lower level through a 52-month observation period. The effect on lymphocytes was apparent by 3 days after exposure, stabilizing at approximately 50% of pre-exposure values for about 7 months, with a return to pre-exposure levels in the following 4 yr. There was a progressive and significant (P less than 0.001) decline in platelet counts during the 52-month post-exposure period. The pattern of response in erythrocyte parameters was complex. Immediately after the accident, these values were less than the pre-exposure mean level; they gradually increased (P less than 0.001) for approximately 2 yr and then began a progressive decline (P less than 0.001).
mesh_terms: D000062:Accidents, Occupational; D000576:Americium / Q000009:adverse effects*; D001753:Blast Injuries / Q000097:blood*; D001772:Blood Cell Count; D001822:Body Burden; D002057:Burns, Chemical / Q000097:blood*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009688:Nuclear Reactors; D011832:Radiation Injuries / Q000097:blood*; D013997:Time Factors; D014861:Washington
chemical_list: D006454:Hemoglobins; D000576:Americium