Sialographic study in patients with and without antibodies to Sjögren's syndrome A (Ro).
Antibodies to Sjögren's syndrome A (SS-A) (Ro) antigen were detected in 13 of 16 (81%) patients with sicca alone and 18 of 34 (54%) patients with systemic lupus erythematosus (SLE). Antibodies to Sjögren's syndrome B (SS-B) (La, Ha) antigen were detected in 7 of 16 (44%) patients with sicca alone. These percentages were statistically higher than those in other types of connective tissue diseases. There were no direct correlations between titers of antibodies to SS-A (Ro) and severity of sialographic abnormalities in 35 patients with Sjögren's syndrome (SS). However comparison of a total of 20 sialograms obtained from patients with antibodies to SS-A (Ro) showed more advanced changes than in a total of 36 sialograms from patients without antibodies to SS-A (Ro) in systemic lupus erythematosus, mixed connective tissue disease, progressive systemic sclerosis and rheumatoid arthritis. These results suggested that antibody to SS-A (Ro) may be a good indicator of subclinical SS.
D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis*; D000918:Antibody Specificity; D000941:Antigens / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology; D001324:Autoantigens; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000276:immunology; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D012595:Scleroderma, Systemic / Q000276:immunology; D012796:Sialography; D012859:Sjogren's Syndrome / Q000276:immunology*; D014157:Transcription Factors / Q000276:immunology; D000097585:SS-B Antigen; D000099207:SS-A Antigen
D000974:Antibodies, Antinuclear; D000941:Antigens; D001324:Autoantigens; D020733:RNA, Small Cytoplasmic; D012261:Ribonucleoproteins; D014157:Transcription Factors; D000097585:SS-B Antigen; D000099207:SS-A Antigen; C116006:RO60 protein, human; C035356:SS-A antibodies; C035357:SS-B antibodies