[Effect of central and peripheral serotonin-reactive structures on the cardiovascular system and respiration].
In chronic experiments on dogs, the heterogenic effect of serotoninergic structures of the upper and lower parts of the limbic cortex's anterior area was revealed in respect to the heart rate and respiration. Administration of 0.2 mg of serotonin-adipinate (through chemotrodes, bilaterally, in 0.02 ml of saline) into the upper part induced deceleration of the heart rate and respiration whereas the contrary effect occurred after the administration into the lower part. Administration of saline exerted no effect and the i. m. administration of serotonin-adipinate and 5-oxytryptophane (0.5 mg/kg) exerted either no effect as well or a short-lasting one.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000272:Adipates / Q000494:pharmacology; D000818:Animals; D002320:Cardiovascular Physiological Phenomena; D002319:Cardiovascular System / Q000187:drug effects; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D008032:Limbic System / Q000187:drug effects / Q000502:physiology*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012119:Respiration / Q000187:drug effects; D012701:Serotonin / Q000502:physiology*
D000272:Adipates; D011985:Receptors, Serotonin; D012701:Serotonin; D006916:5-Hydroxytryptophan
Vliianie tsentral'nykh i perifericheskikh serotoninoreaktivnykh struktur na serdechno-sosudistuiu sistemu i dykhanie.