The adjuvanticity of interleukin 1 in vivo.
Interleukin 1 (IL 1) was shown to enhance in vivo secondary antibody responses of mice to a protein antigen. The activity was found to be dose and time dependent. The maximum enhancing effect was obtained with 2000 LAF units of IL 1 given 2 hr after the priming dose of antigen. The observation is consistent with the in vitro immunoenhancing activities of IL 1 and strongly suggests that this protein may be an important mediator of host defense responses, as well as of the stimulatory effects of some adjuvants.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000502:physiology*; D000818:Animals; D000917:Antibody Formation; D002417:Cattle; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000008:administration & dosage / Q000502:physiology*; D007951:Leukemia, Myeloid / Q000276:immunology; D008070:Lipopolysaccharides / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D012710:Serum Albumin, Bovine / Q000008:administration & dosage / Q000276:immunology; D013045:Species Specificity
D000276:Adjuvants, Immunologic; D007375:Interleukin-1; D008070:Lipopolysaccharides; D012710:Serum Albumin, Bovine