title: Histochemical changes in mucus in duodenal ulceration.
abstract: In duodenal ulceration the Alcian blue staining acid mucosubstances in goblet cells are reduced and the goblet cells themselves disappear. At the same time periodic acid-Schiff (PAS) staining neutral mucosubstances appear in the cells of the surface epithelium. These changes have been measured quantitatively with the help of a Vickers M86/0010 Scanning and Integrated Microdensitometer. During healing the changes are reversed. It is suggested that these changes suggest a metaplasia towards a gastric type mucosa as a protective response to the presence of ulceration.
mesh_terms: D002452:Cell Count; D004381:Duodenal Ulcer / Q000378:metabolism* / Q000473:pathology; D004386:Duodenum / Q000378:metabolism; D006651:Histocytochemistry; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism / Q000473:pathology; D009077:Mucins / Q000378:metabolism*; D009093:Mucus / Q000378:metabolism*; D010503:Periodic Acid-Schiff Reaction
chemical_list: D009077:Mucins