Purge and trap flame photometric gas chromatography technique for the speciation of trace organotin and organosulfur compounds in a human urine standard reference material (SRM).
Ultratrace levels of organotin species and an organosulfur compound were detected in a National Bureau of Standards (NBS) human urine Standard Reference Material, SRM 2670, and a previously certified urine SRM 2672, using a purge and trap system coupled to a gas chromatograph equipped with a flame photometric detector. samples of the SRM were treated with sodium borohydride to form volatile tin hydrides. Species detected included dimethyltin (1.04 ng/ml), butyltin (0.03 ng/ml), and dimethyl-disulfide (2.73 ng/ml) in the new stock of freeze dried human urine SRM 2670 being prepared for issue by NBS and methyltin (1.0 ng/ml), butyltin (1.5 ng/ml), and inorganic tin (28.1 ng/ml) in the old stock of SRM 2672. This analytical technique should have useful applications in studies that are needed to develop a toxicological data base and monitoring programs for human organotin exposure.
D002849:Chromatography, Gas / Q000379:methods; D004220:Disulfides / Q000652:urine; D006801:Humans; D009947:Organotin Compounds / Q000652:urine*; D010783:Photometry / Q000379:methods; D012015:Reference Standards; D013455:Sulfur / Q000652:urine*
D004220:Disulfides; D009947:Organotin Compounds; C021181:dimethyl disulfide; D013455:Sulfur