title: Effects of antidepressants on the EEG of the rat.
abstract: The aim of the study was to detect whether antidepressants cause specific EEG effects in rats. The results presented are based on quantitative evaluation of a series of 6-min vigilance-controlled EEG recordings in rats under standardized conditions. Standard conditions comprised: a vigilance control, a rigid test procedure in which drugs and rats are divided according to a Greek-Latin square, and the same electrode placement. Computer analyses are based on an analysis of variance for which the averaged power spectral values are used as input. The use of a moving window technique in this type of EEG studies is introduced in comparison to the well-known use of fixed frequency bands. A number of antidepressants have been tested and several common characteristics are found.
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D003201:Computers; D004569:Electroencephalography; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000928:Antidepressive Agents