Treatment and improvement of the breeding system of the albumin-deficient and jaundiced strain of rats.
The AJR (alb/alb, j/j) strain is semi-lethal and the rats die at about two weeks of age. Cross breeding with a pari of ACJ (alb/alb, j/+) is required for maintenance and production. We studied the treatment of AJRs for improvement of the breeding system. AJRs with jaundice on the skin at about 7 days of age were intraperitoneally administered 1 ml/rat of normal rat serum every few days and irradiated with visible light for 14 hours a day in an irradiation box. This treatment allowed us to obtain mature AJRs. The treatment was effective when applied for short periods of 1-4 weeks of age. The frequency of maturation of the treated AJRs was about 27% and the best mating combination was a female ACJ and male AJR. The treatment of AJRs, made the progeny test for the selection of ACJs for breeding pairs of ACJ X ACR unnecessary and increased the frequency of appearance of AJRs to 50%.
D000818:Animals; D001947:Breeding; D005260:Female; D007565:Jaundice / Q000628:therapy / Q000662:veterinary*; D008297:Male; D010789:Phototherapy; D051381:Rats; D011919:Rats, Inbred Strains / Q000235:genetics*; D012376:Rodent Diseases / Q000235:genetics*; D012709:Serum Albumin / Q000172:deficiency*
D012709:Serum Albumin