Nonsensitized murine B lymphocytes produce mouse interferon alpha/beta in response to foreign cells.
Nonsensitized murine lymphocytes produced mouse interferon when cocultured with foreign and transformed cells. Neutralization tests revealed that this interferon was of the alpha/beta type. The B lymphocyte appeared responsible for the bulk of the interferon production as determined by cell "panning," complement-mediated depletion, and immunofluorescence experiments.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D007369:Interferon Inducers / Q000276:immunology*; D007370:Interferon Type I / Q000096:biosynthesis*; D007739:L Cells / Q000378:metabolism*; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000166:cytology
D007369:Interferon Inducers; D007370:Interferon Type I