HLA class-II-specific T-lymphocyte clones with dual alloreactive functions.
The relationship between T lymphocytes that proliferate in response to HLA class II antigens and those that mediate the cytotoxic response toward HLA class II target antigens was investigated. Alloreactive T-cell clones were derived under conditions in which the likelihood of clonality was high. Three populations of HLA class-II-specific T cells were identified. Two of these populations exhibited only HLA class-II-directed cytotoxicity or HLA class-II-induced proliferation. The third population of T cells exhibited both of these responses.
D000918:Antibody Specificity; D002455:Cell Division; D002999:Clone Cells; D003602:Cytotoxicity, Immunologic; D006680:HLA Antigens / Q000145:classification / Q000276:immunology; D006801:Humans; D007519:Isoantigens / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D006680:HLA Antigens; D007519:Isoantigens