Aromatization: important for testosterone's developmental influences on the neurocircuits mediating cervically stimulated prolactin secretion in the female rat.
Adult female rats treated neonatally with testosterone or estrogen fail to respond to cervical stimulation with episodic prolactin release. The developmental action of testosterone is inhibited by co-administration of 1,4,6-androstatriene-3,17-dione at a dose sufficient to inhibit the testosterone-induced rise in estrogen receptors in limbic brain cell nuclei. These data suggest the importance of aromatization for testosterone action.
D000818:Animals; D002584:Cervix Uteri; D003345:Corticosterone / Q000097:blood; D005260:Female; D007986:Luteinizing Hormone / Q000097:blood; D011247:Pregnancy; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D013739:Testosterone / Q000502:physiology*
D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D003345:Corticosterone