Experimental assessment of the protective activity of diazepam on the acute toxicity of chloroquine.
The dose of diazepam that reduces the mortality rate of acute intoxications with chloroquine was determined: The oral LD 50 of chloroquine (330 mg/kg) was administered and immediately thereafter diazepam was injected intraperitoneally to male and female rats at dose levels of 2.5, 7.5, 20, 55, and 148 mg/kg. An untreated group served as control. A significant decrease of the mortality rate was observed at the dose levels 7.5, 20, and 55 mg/kg with optimal effect at 20 mg/kg. This mortality rate was analysed by analysis of variance. The occurrence of two types of symptoms: convulsions and respiratory disturbances was analysed by the chi square method.
D000704:Analysis of Variance; D000818:Animals; D002738:Chloroquine / Q000633:toxicity*; D003975:Diazepam / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D002738:Chloroquine; D003975:Diazepam