title: Pharmacological properties of the antiinflammatory agent 10-methylamine-11-H-indeno-[1,2-b]quinolin-11-one (MB432).
abstract: 10-Methylamine-11-H-indeno [1,2-b] quinolin-11-one (MB432) was found to be a prostaglandin synthetase inhibitor, to display antiinflammatory activity in carrageenin edema and cotton pellet granuloma tests in rats, and to exert analgesic action in paw pressure test in rats and in the writhing test in mice. The therapeutic index (LD50/ED50) for antiinflammatory and analgesic effect of MB432 is higher than that of indomethacin (IND) and phenylbutazone (PHB). The acute toxicity of MB432 is low but the drug showed high ulcerogenic activity. The ratio of medium ulcerogenic to median antiinflammatory and analgesic doses of MB432 is comparable to that of PHB but higher than for IND.
mesh_terms: D000634:Aminoquinolines / Q000494:pharmacology* / Q000633:toxicity; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010653:Phenylbutazone / Q000494:pharmacology; D000091402:Prohibitins; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced
chemical_list: D000634:Aminoquinolines; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; C000717332:Phb protein, rat; D000091402:Prohibitins; C040097:10-methylamino-11-H-indeno(2-b)quinoline-11-one; D010653:Phenylbutazone; D007213:Indomethacin