[Correction of biochemical and immunological indices in colonic cancer using optimal doses of retinyl acetate and ascorbic acid].
Blood plasma retinol level in normal donors and patients with colonic carcinoma was measured by high-pressure liquid chromatography and the concentration of p-hydroxyphenyl lactic and homogentizine acids by Gas Chromatograph Mass Spectrometer MAT-311A using 2H4-p-hydroxyphenylacetic acid as internal reference. The functional activity of lymphocytes was estimated from the proliferative response to alloantigens in a one-way mixed lymphocyte culture and in blast transformation reaction to Con A and pokeweed mitogen. After systematic intake of retinyl acetate and ascorbic acid in optimally high doses, the patients manifested an increase in vitamin C level in plasma and lymphocytes and a lowering of p-hydroxyphenyl lactic acid excretion. Blood plasma retinol remained unchanged. Daily intake of retinyl acetate and ascorbic acid for 8-12 days produced a significant increase of lymphocyte proliferation in response to alloantigens in mixed lymphocyte culture and blast transformation reaction to suboptimal mitogen doses.
D000328:Adult; D000368:Aged; D001205:Ascorbic Acid / Q000097:blood / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000188:drug therapy* / Q000276:immunology / Q000378:metabolism; D004224:Diterpenes; D006713:Homogentisic Acid / Q000652:urine; D006801:Humans; D008213:Lymphocyte Activation; D008875:Middle Aged; D010666:Phenylpropionates / Q000652:urine; D000084562:Retinyl Esters; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use
D004224:Diterpenes; D010666:Phenylpropionates; D000084562:Retinyl Esters; D014801:Vitamin A; C001418:4-hydroxyphenyllactic acid; C009166:retinol acetate; D006713:Homogentisic Acid; D001205:Ascorbic Acid
Korrektsiia biokhimicheskikh i immunologicheskikh pokazateleĭ pri rake tolstoĭ kishki optimal'nymi dozami retinilatseta i askorbinovoĭ kisloty.