In vitro inhibition of alveolar macrophage phagocytosis by ozone: absence of a role for serum or mode of ozone administration.
Cell culture conditions which protected rat lung fibroblasts from O3-induced injury were tested for their protection potential in retaining the phagocytic activity of O3-exposed rat alveolar macrophages. Conditions which protected fibroblasts from O3-related loss of 51Cr were ineffectual in preventing O3-related loss of macrophage phagocytic activity. It is suggested that the macrophage phagocytic function may be especially sensitive to H2O2 generated by the O3.
D000818:Animals; D001790:Blood Physiological Phenomena; D005260:Female; D066298:In Vitro Techniques; D008264:Macrophages / Q000187:drug effects*; D008297:Male; D010126:Ozone / Q000633:toxicity*; D010587:Phagocytosis / Q000187:drug effects*; D011650:Pulmonary Alveoli / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D010126:Ozone