Nuclear hypersegmentation in the myeloma cells of a patient with multiple myeloma.
A patient with multiple myeloma in whom the bone marrow plasmablasts showed extensive lobulation is described. In addition to numerous lobes, some of the nuclei had a cerebriform appearance, similar to that observed in Sézary cells. The possible relation of this phenomenon to the expression of the altered function of the malignant cells is discussed.
D000368:Aged; D001853:Bone Marrow / Q000648:ultrastructure*; D002467:Cell Nucleus / Q000648:ultrastructure*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008854:Microscopy, Electron; D009101:Multiple Myeloma / Q000276:immunology / Q000648:ultrastructure*
D007136:Immunoglobulins