Phosphono-platelet activating factor I. Synthesis of 1-O-hexadecyl-2-O-acetyl-glyceryl-3-(2-trimethyl ammonium-methyl) phosphonate and its platelet activating potency.
The total synthesis of 1-O-alkyl-2-acetyl-3-glyceryl-(2-trimethyl ammoniummethyl) phosphonate, the phosphono analogue of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, is described. The phosphonolipid shows much lower activity than the phospholipid stimulating serotonin release from rabbit platelets.
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D010743:Phospholipids / Q000138:chemical synthesis / Q000494:pharmacology; D010972:Platelet Activating Factor / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D011817:Rabbits; D012701:Serotonin / Q000378:metabolism; D013329:Structure-Activity Relationship
D010743:Phospholipids; D010972:Platelet Activating Factor; C028299:phosphonolipids; D012701:Serotonin; C039703:phosphono-platelet activating factor