Influence of perinatal nutrition on hepatic drug metabolism in the adult rat.
Pregnant rats were fed high-fat (HF, 35% calories) or low-fat (LF, 5% calories) diet from 18 days of gestation to the end of the suckling period. Thereafter, male progeny were fed stock diet for 6 months, then sacrificed or challenged for 3 days with HF diet. There were no immediate posttreatment effects at 30 days of age on liver microsomal cytochrome P-450 or b5, aminopyrine (AP) N-demethylase or benzo(a)pyrene (BP) hydroxylase. At 7 months, cytochrome P-450 was lower in LF-fed than in HF-fed animals. High-fat challenge reduced cytochrome P-450 and cytochrome b5 content in both groups, AP N-demethylase only in LF animals and BP hydroxylase only in HF animals. These differential effects of perinatal exposure to diet on the later response of microsomal mixed-function oxidases to fat challenge suggest that early dietary experience may regulate the pattern of drug metabolism in adult life.
D000633:Aminopyrine N-Demethylase / Q000032:analysis; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001579:Benzopyrene Hydroxylase / Q000032:analysis; D004041:Dietary Fats / Q000494:pharmacology*; D005260:Female; D007774:Lactation; D008099:Liver / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D004041:Dietary Fats; D004364:Pharmaceutical Preparations; D001579:Benzopyrene Hydroxylase; D000633:Aminopyrine N-Demethylase