Spiking fever induced by isoniazid.
In a 48-year-old man, a consistent pattern of spiking fever occurred ten days after the initiation of therapy with isoniazid and rifampin. The fever recurred upon rechallenge with isoniazid, but not with rifampin. Isoniazid has the potential to induce fever, and this is thought to be a hypersensitivity reaction.
D004342:Drug Hypersensitivity / Q000209:etiology; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000009:adverse effects; D013997:Time Factors
D007538:Isoniazid; D012293:Rifampin