title: Protein pattern of cerebrospinal fluid in various neurological diseases.
abstract: CSF/serum albumin and immunoglobulin G ratios were determined in 520 patients suffering from various neurological diseases. Blood-brain barrier impairment was detectable in most cases of spinal tumour, meningitis, Guillain-Barré syndrome and in two-thirds of the patients with cerebral infarctions. A local IgG formation in the CNS has to be assumed for some cases of meningitis considering the course of the protein dysequilibrium. Autochthonous IgG production together with a barrier dysfunction was found in patients with encephalitis, meningoradiculitis and neurosyphilis. In cases of multiple sclerosis local IgG formation in the CNS was the predominant finding.
mesh_terms: D001812:Blood-Brain Barrier; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid*; D002544:Cerebral Infarction / Q000134:cerebrospinal fluid; D004660:Encephalitis / Q000134:cerebrospinal fluid; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D008581:Meningitis / Q000134:cerebrospinal fluid; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid; D009494:Neurosyphilis / Q000134:cerebrospinal fluid; D011129:Polyradiculoneuropathy / Q000134:cerebrospinal fluid; D012709:Serum Albumin / Q000134:cerebrospinal fluid*; D013120:Spinal Cord Neoplasms / Q000134:cerebrospinal fluid
chemical_list: D007074:Immunoglobulin G; D012709:Serum Albumin