title: Ia-expressing cells and T lymphocytes of different subsets in peripheral nerve tissue during experimental allergic neuritis in Lewis rats.
abstract: Inflammatory infiltrates in sciatic nerves during the acute phase of experimental allergic neuritis in the Lewis rat have been characterized with regard to occurrence and distribution of Ia-expressing cells and T-lymphocyte subsets by the help of an immunohistochemical double-staining technique, enabling the simultaneous visualization of T lymphocytes and Ia-expressing non-T cells. Large numbers of Ia-expressing irregular macrophage-like/dendritic cells were seen both within inflammatory infiltrates and within afflicted nervous tissue. Many W3/13-reactive T lymphocytes of both 'helper' and 'suppressor/cytoxic' phenotypes appeared in close contact with these Ia-expressing non-T cells, particularly within the infiltrates. B lymphocytes and plasma cells were relatively few and mainly found close to endoneurial vessels.
mesh_terms: D000818:Animals; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D008297:Male; D009417:Nerve Tissue / Q000166:cytology*; D009444:Neuritis, Autoimmune, Experimental / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D012584:Sciatic Nerve / Q000166:cytology; D013601:T-Lymphocytes / Q000145:classification* / Q000276:immunology
chemical_list: D000949:Histocompatibility Antigens Class II