A possible method to study transient effects of ototoxic agents on the vestibular system.
A method is described in which the direct influence of anoxia and ototoxic agents on the vestibular system can be studied. After fenestration of the lateral semicircular canal in pigeons, a vestibular whole nerve action potential (VAP) could be recorded during acoustic stimulation. The cochlear whole nerve action potential (CAP) was recorded simultaneously. The influence of ototoxic agents and anoxia upon the amplitude of these action potentials was studied.
D000818:Animals; D003056:Cochlear Nerve / Q000187:drug effects; D010856:Columbidae; D004976:Ethacrynic Acid / Q000633:toxicity*; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005665:Furosemide / Q000633:toxicity*; D007612:Kanamycin / Q000633:toxicity*; D014725:Vestibular Nerve / Q000187:drug effects; D014722:Vestibule, Labyrinth / Q000187:drug effects*
D007612:Kanamycin; D005665:Furosemide; D004976:Ethacrynic Acid