Chromosome replication in normal and transformed human lymphocytes.
We analyzed the late-replication patterns of human B-lymphocyte chromosomes before and after transformation by Epstein-Barr virus. There were no statistically significant differences between normal cells and transformed cells derived from the same male individual; therefore, the order of termination of chromosome replication was unchanged by transformation. We also examined the replication patterns of T lymphocytes from the same donor and found no differences between normal B and T cells.
D001402:B-Lymphocytes / Q000648:ultrastructure*; D002460:Cell Line; D002472:Cell Transformation, Viral; D002875:Chromosomes / Q000648:ultrastructure; D004261:DNA Replication; D006801:Humans; D008297:Male; D013601:T-Lymphocytes / Q000648:ultrastructure