Pharmacokinetics of piperacillin and gentamicin following intravenous administration to dogs.
Piperacillin sodium was administered intravenously to dogs, alone or in combination with gentamicin, twice a day (approximately 5 hr apart) for 36-37 days. The pharmacokinetics of neither drug changed in the presence of the other; however, the percentage of the gentamicin dose recovered in the urine decreased significantly when coadministered with piperacillin. The data demonstrate that interaction between the two drugs in urine is feasible.
D000818:Animals; D004285:Dogs; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000378:metabolism*; D006207:Half-Life; D007263:Infusions, Parenteral; D007700:Kinetics; D008297:Male; D010878:Piperacillin / Q000008:administration & dosage / Q000378:metabolism*
D005839:Gentamicins; D010878:Piperacillin