Tumorigenicity of cells transformed by adenovirus type 12 by evasion of T-cell immunity.
Evidence is presented that cells transformed by adenovirus type 12 are oncogenic because they escape from T-cell immunity. This effect is brought about by reducing the expression of class I transplantation antigens and is a function of the protein translated from the 13S mRNA, transcribed from early region 1a. These findings establish a novel mechanism by which transformed cells can acquire an oncogenic phenotype.
D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D006649:Histocompatibility Antigens / Q000032:analysis; D008285:Major Histocompatibility Complex; D051379:Mice; D008819:Mice, Nude; D012333:RNA, Messenger / Q000032:analysis; D051381:Rats; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D006649:Histocompatibility Antigens; D012333:RNA, Messenger