[Effects of intragastric calcium on gastric acid secretion and release of gastrin in normal man and in various pathological cases].
Two hundred millilitres of an isotonic solution of CaCl2 (0,118 M) were injected and left 15 min in the stomach of normal subjects (SN1; n = 21), of patients with gastric ulcer (UG; n = 16), patients with duodenal ulcer (UD; n = 40), patients with normochlorhydric gastritis (G1; n = 13) and patients with hypo- or achlorhydric gastritis (G2; n = 7). Gastric acid secretion and gastrinemia were measured during 90 min. After intragastric calcium injection, the acid secretion was increased during 60 min in almost all subjects (87 to 100 p. 100 of subjects in the various groups) whereas gastrin release was increased in the majority (57 to 84 p. 100) of cases. The possible dissociation between the acid and gastrinic responses implies that the calcium-induced acid response is independent of the calcium-induced gastrin release. During control experiments in normal individuals, continuous intragastric perfusion (300 ml/h) of NaCl 0.15 M failed to alter gastric acid secretion or gastrin release, whereas continuous intragastric perfusion of CaCl2 0,118 M enhanced gastric acid secretion and gastrin release. The action of CaCl2 0,118 M is therefore not attributable to gastric distension but directly to calcium itself. The stimulation of acid secretion by intragastric calcium was more conspicuous in patients with gastric or duodenal ulcer than in normal subjects. The release of gastrin was higher in gastritis and duodenal ulcer than in the normal group. It is hypothesized that intragastric calcium increases the cholinergic tone of the parietal cell.
D000328:Adult; D002122:Calcium Chloride / Q000008:administration & dosage / Q000494:pharmacology*; D004381:Duodenal Ulcer / Q000378:metabolism; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000378:metabolism*; D005756:Gastritis / Q000378:metabolism; D005767:Gastrointestinal Diseases / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013276:Stomach Ulcer / Q000378:metabolism
D005755:Gastrins; D002122:Calcium Chloride
Effet du calcium intragastrique sur la sécrétion gastrique acide et la libération de gastrine chez l'homme normal et dans divers cas pathologiques.