[Dynamics of the formation of anti-idiotypic antibodies in the course of the immune response].
The work demonstrates that after the injection of a heterogenous antigen into rabbits the appearance of antibodies is followed by the "spontaneous" formation of anti-idiotypic antibodies. These anti-antibodies, detected by means of several serological reactions, are specific and have an idiotypic character. Circulating antibody--anti-idiotypic antibody complexes have been detected in the blood of the animals. The injection of autologous anti-idiotypic antibodies into the immunized animals ensures the stimulation of the formation of antibodies and anti-idiotypic antibodies. Immunological memory with respect to anti-idiotypic antibodies develops in the body of the immunized animals.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000008:administration & dosage / Q000032:analysis / Q000096:biosynthesis*; D000918:Antibody Specificity; D000942:Antigens, Bacterial / Q000008:administration & dosage; D003168:Complement Fixation Tests; D006386:Hemagglutination Tests; D007109:Immunity; D007114:Immunization / Q000379:methods; D007130:Immunoglobulin Idiotypes / Q000008:administration & dosage / Q000032:analysis / Q000276:immunology*; D007156:Immunologic Memory; D011135:Polysaccharides, Bacterial; D011817:Rabbits; D013997:Time Factors; D014436:Typhoid-Paratyphoid Vaccines / Q000008:administration & dosage
D000888:Antibodies, Anti-Idiotypic; D000942:Antigens, Bacterial; D007130:Immunoglobulin Idiotypes; D011135:Polysaccharides, Bacterial; D014436:Typhoid-Paratyphoid Vaccines
Dinamika obazovaniia antiidiotipicheskikh antitel v khode immunnogo otveta.