[Fundamental and clinical studies of T-1982 (cefbuperazone) in the field of obstetrics and gynecology].
Tissue concentrations of T-1982 (cefbuperazone) at 100-220 minutes after the completion of 1 g/60 minutes dripping infusion were 8.9-10.6 micrograms/g in the uterus, ovary and oviduct. These concentrations were higher than 80% MIC of the causative organisms, including E. coli, K. pneumoniae, P. mirabilis, Bacteroides and Peptococcus isolated from infections in the field of obstetrics and gynecology. The T-1982 concentration in the retroperitoneal space exudate reached a peak value of 19.6 micrograms/ml at 2 hours after the completion of 1 g/60 minutes dripping infusion and decreased at a constant rate. We administered T-1982 at 2 g per day for a period of 7-9 days to 3 patients with gynecological infectious diseases. All cases proved to respond effectively. No side effects and abnormal laboratory findings were observed.
D000368:Aged; D002513:Cephamycins / Q000378:metabolism* / Q000627:therapeutic use; D005122:Exudates and Transudates / Q000032:analysis; D005260:Female; D006801:Humans; D008875:Middle Aged; D010053:Ovary / Q000378:metabolism; D000292:Pelvic Inflammatory Disease / Q000188:drug therapy; D010388:Pelvis; D014599:Uterus / Q000098:blood supply / Q000378:metabolism
D002513:Cephamycins; C035978:cefbuperazone