Age-related changes in PHA and allogeneic reactivity of human T lymphocytes.
In fifty-four healthy individuals aged from 22 to 53 the response of lymphocytes to PHA stimulation and to stimulation with allogeneic lymphocytes were determined. A linear age-related decrease in reactivity to PHA (r = 0.500, P less than 0.01), as well as to allogeneic stimulation (r = 0.351, P less than 0.01) was found. The correlation between these two parameters of T lymphocyte function was weak (r = 0.207, not significant).
D000293:Adolescent; D000328:Adult; D000375:Aging; D002478:Cells, Cultured; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D008934:Mitogens; D010835:Phytohemagglutinins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology*
D008934:Mitogens; D010835:Phytohemagglutinins