Production of the hydroxylated metabolites of vitamin D in a neonate with a single hypoplastic-dysplastic kidney.
The ability to produce dihydroxylated metabolites of vitamin D was studied in a term neonate suffering from severe renal insufficiency. The infant died at age 26 days owing to end-stage renal failure and the necropsy examination showed a single dysplastic kidney weighing 1.5 g. At age 2 weeks the serum levels of the dihydroxylated metabolites of vitamin D were found to be normal and a pronounced increase was noted 24 hours after injection of 100 000 IU vitamin D2. The study suggests that during the neonatal period a small renal mass is sufficient to maintain optimal circulating levels of the dihydroxylated metabolites of vitamin D.
D004100:Dihydroxycholecalciferols / Q000097:blood*; D004872:Ergocalciferols / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000473:pathology; D007668:Kidney / Q000002:abnormalities* / Q000378:metabolism / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000473:pathology; D008297:Male
D004100:Dihydroxycholecalciferols; D004872:Ergocalciferols