Linkage analyses and biochemical genetics of sorbitol dehydrogenase-1 (Sdh-1) in the mouse.
Electrophoretic variation of sorbitol dehydrogenase has been found in Mus musculus; the SDH-1 A phenotype migrates further toward the cathode under the conditions used than the SDH-1B phenotype. Mice with the SDH-1B phenotype have enzyme activity reduced to 25% of that found in mice with the SDH-1A phenotype, but no differences in heat stability, pH profile, or Km for fructose were found. The gene Sdh-1 is inherited as an autosomal condominant located on chromosome 2, and the gene order obtained, with genetic distance calculated as percentage recombination +/- SE was Sdh-1--1.9 +/- 1.4--pa--16.4 +/- 3.6--a--3.9 +/- 1.9--bp.
D000818:Animals; D002874:Chromosome Mapping; D003593:Cytoplasm / Q000201:enzymology; D008040:Genetic Linkage; D007527:Isoenzymes / Q000235:genetics; D007064:L-Iditol 2-Dehydrogenase / Q000235:genetics* / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D011995:Recombination, Genetic; D013379:Substrate Specificity; D013401:Sugar Alcohol Dehydrogenases / Q000235:genetics*
D007527:Isoenzymes; D013401:Sugar Alcohol Dehydrogenases; D007064:L-Iditol 2-Dehydrogenase