[Blood level kinetics of sodium noramidopyrine methanesulfonate (Analgin) in late pregnancy].
The pharmacokinetic parameters were investigated after a single application of 1,0 g of Analgin to women in labour in comparison with a nonpregnant control group. During the late stage of pregnancy the distribution volume is only slightly increasing. For Analgin a fundamental influence on the level of serum concentration could not be shown. The biological half-life of Analgin shows remarkable individual differences and does not differ significantly between the two investigated groups. Therefore, during pregnancy a change of the applied dose is not indicated.
D000328:Adult; D000632:Aminopyrine / Q000031:analogs & derivatives*; D004177:Dipyrone / Q000097:blood*; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D011247:Pregnancy; D011263:Pregnancy Trimester, Third
D000632:Aminopyrine; D004177:Dipyrone
Untersuchungen zur Blutspiegelkinetik von Noramidopyrinmethan-sulfonat-Natrium (Analgin) in der Spätschwangerschaft.