An HLA-DR5 homozygous cell line expresses two DS (I-A-like) molecules.
Previous studies have indicated that LLA-DR homozygous cell lines express two DR molecules but only a single DS (I-A-like) molecule. This report demonstrates that an HLA-DR5 homozygous cell line expresses at least two distinct DS molecules. These two DS molecules are formed by the association of a single DS alpha chain with either of two DS beta chains. Four distinct Ia molecules have now been identified from this DR5 homozygous cell line.
D000937:Antigen-Antibody Reactions; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001402:B-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D055598:Chemical Phenomena; D002621:Chemistry; D004591:Electrophoresis, Polyacrylamide Gel; D006681:HLA-D Antigens; D015805:HLA-DR5 Antigen; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D010455:Peptides / Q000032:analysis
D000961:Antilymphocyte Serum; D006681:HLA-D Antigens; D015805:HLA-DR5 Antigen; D000949:Histocompatibility Antigens Class II; D010455:Peptides