[Effect of different doses of naloxone on the course of hemorrhagic shock in rats].
Experiments on 52 Wistar rats were made to induce hemorrhagic shock by exemption of 40% blood from the jugular vein, which was followed by intravenous injection of either physiological solution or naloxone in doses of 0.4 and 1 mg/kg. Naloxone in a dose of 1 mg/kg was found to improve the animals' status as compared with the control (injection of physiological solution). On the contrary, injection of naloxone in a dose of 0.4 mg/kg led to the deterioration of the animals' status. Based on these data it is suggested that different opiate receptors play an inconclusive role in the development and progress of hemorrhagic shock induced by acute hemorrhage.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D009270:Naloxone / Q000009:adverse effects / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012771:Shock, Hemorrhagic / Q000188:drug therapy*
D009270:Naloxone
Vliianie razlichnykh doz naloksona na techenie gemorragicheskogo shoka u krys.