Uptake of adenosine by cultured cerebral vascular smooth muscle cells.
Adenosine uptake by cerebral smooth muscle cells is a carrier-mediated process. The Km value for adenosine uptake is 10.0 microM and the Vmax is 0.95 nmol/min-mg cell protein. This uptake system is inhibited by the adenosine analog 2-chloroadenosine at low adenosine concentrations. These results prove the existence of a nucleoside transport system associated with cerebral smooth muscle.
D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000098:blood supply*; D002478:Cells, Cultured; D007700:Kinetics; D051379:Mice; D009131:Muscle, Smooth, Vascular / Q000378:metabolism*
D000241:Adenosine