Low-affinity E-rosette-blocking factor in hemodialysis-treated patients in chronic renal failure.
Enumeration of total E-rosette-forming cells (t-ERFC) enabled 30 renal failure patients on hemodialysis to be classified into three groups: group 1 with normal numbers of t-ERFC, and groups 2A and 2B with reversibly and irreversibly reduced numbers, respectively. Duration of dialysis treatment was the only distinguishing feature between these three groups, being shorter for group 1 than for group 2A (P less than 0.02) and shorter for group 2A than for group 2B (P less than 0.001). However, a rosette-blocking factor (RBF) was demonstrated in all three groups which predominantly affected the low-affinity ERFC (i.e., total ERFC minus active ERFC). This factor could be partially absorbed (P less than 0.01) on normal lymphocytes and showed increased activity after a single dialysis session, suggesting the removal by dialysis of a putative anti-RBF substance.
D000017:ABO Blood-Group System / Q000276:immunology; D000328:Adult; D000368:Aged; D000818:Animals; D001798:Blood Proteins / Q000032:analysis*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000276:immunology* / Q000628:therapy; D008077:Lipoproteins, LDL; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012397:Rosette Formation; D012756:Sheep / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D000017:ABO Blood-Group System; D001798:Blood Proteins; D008077:Lipoproteins, LDL; C022060:rosette-inhibiting factor