title: Taurine depletion of lactating rats: effects of developing pups.
abstract: Taurine is in high concentration in the milk of most mammals. Intraperitoneal injection of [35S]taurine into lactating rats leads to the appearance of label in the milk, and the dpm/ml milk are significantly decreased by treatment with guanidinoethyl sulfonate (GES), an analog of taurine. Pups nursed by GES-treated mothers have retinal taurine levels about 45% lower than controls during the period from birth to 17 days old suggesting a dependence of retinal taurine on dietary intake during the neonatal period. These deficits in taurine may be associated with visual dysfunction as seen in adult rats depleted of retinal taurine.
mesh_terms: D000375:Aging; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D007700:Kinetics; D007774:Lactation; D008892:Milk / Q000032:analysis; D011247:Pregnancy; D051381:Rats; D012160:Retina / Q000187:drug effects / Q000254:growth & development*; D013462:Sulfur Radioisotopes; D013654:Taurine / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D013462:Sulfur Radioisotopes; D013654:Taurine