Extravascular lung water: effects of ionic and nonionic contrast media.
The effects of right atrial injections of Renografin 76 (meglumine diatrizoate), hypertonic (5%) sodium chloride, and iohexol, a new nonionic contrast medium, on sequential measures of left atrial pressure and extravascular lung water in anesthetized dogs were studied. Renografin 76 caused significant transient elevations of extravascular lung water; control levels were reestablished at 15-20 minutes after injection. These changes occurred in the absence of significant changes in left atrial pressure. Iohexol reduced extravascular lung water slightly while hypertonic saline transiently increased it. The increased extravascular lung water after right atrial injections of ionic contrast medium can only partially be explained by the tonicity of the medium. This increase was not observed with nonionic medium, suggesting that nonionic media may be preferable imaging agents in patients with underlying lung or heart disease, and may be more suitable for digital intravenous examinations.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D003287:Contrast Media / Q000494:pharmacology*; D003974:Diatrizoate Meglumine / Q000494:pharmacology; D004285:Dogs; D005110:Extracellular Space / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D007472:Iohexol; D008168:Lung / Q000187:drug effects* / Q000378:metabolism; D012462:Saline Solution, Hypertonic; D014283:Triiodobenzoic Acids / Q000494:pharmacology
D003287:Contrast Media; D012462:Saline Solution, Hypertonic; D014283:Triiodobenzoic Acids; D003974:Diatrizoate Meglumine; D007472:Iohexol