Cytochrome P-450 metabolic-intermediate complex formation from p-aminobenzoic acid esters and other arylamines.
Metabolism of a series of p-aminobenzoic acid esters by rat liver microsomal fractions resulted in the formation of cytochrome P-450 metabolic - intermediate complexes. With conditions that allowed complex formation to proceed to completion, about 20% of control rat cytochrome P-450 was sequestered as a complex. Phenobarbital, but not beta-naphthoflavone induced additional cytochrome P-450, which with specific esters could be complexed to about 60%. For other esters, the induced cytochrome maximally complexed to about 20%, as was seen in uninduced rats. The two groups of p-aminobenzoic acid esters could not be readily delineated by lipid/water partition coefficients or steric factors.
D010129:4-Aminobenzoic Acid / Q000378:metabolism*; D000588:Amines / Q000378:metabolism*; D062365:Aminobenzoates / Q000378:metabolism*; D000818:Animals; D001571:Benzoflavones / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D019324:beta-Naphthoflavone
D000588:Amines; D062365:Aminobenzoates; D001571:Benzoflavones; D019324:beta-Naphthoflavone; D003577:Cytochrome P-450 Enzyme System; D010129:4-Aminobenzoic Acid; D010634:Phenobarbital