Epidural bupivacaine, chloroprocaine, or lidocaine for cesarean section--maternal and neonatal effects.
The effects of epidural anesthesia on maternal blood pressure, newborn Apgar scores, neonatal acid-base status, and the early neonatal neurobehavioral scale (ENNS) were studied in 54 pregnant women undergoing cesarean section. Maternal and neonatal blood levels of the local anesthetics were also determined. Group 1 (n = 16) received 0.75% bupivacaine, group 2 (n = 18) received 3% chloroprocaine, group 3 (n = 11) received 2% lidocaine, and group 4 (n = 9) received 2% lidocaine with 1:200,000 epinephrine. The incidence of maternal hypotension did not differ significantly among the four groups. Fetal outcome as determined by Apgar scores, acid-base status, and neurobehavioral testing was equally good in all four groups. At delivery, the fetal/maternal concentration ratio of bupivacaine was 0.27, that of lidocaine without epinephrine 0.48, and that of lidocaine with epinephrine 0.58. Chloroprocaine was detected in 12 maternal samples, in seven umbilical venous samples, and in six umbilical arterial samples. It is concluded that epidural anesthesia as administered in this study had no adverse effect on the newborn Apgar scores, cord acid-base status, or the ENNS.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000328:Adult; D000767:Anesthesia, Epidural / Q000009:adverse effects*; D000773:Anesthesia, Obstetrical / Q000009:adverse effects*; D000779:Anesthetics, Local / Q000009:adverse effects* / Q000097:blood; D001034:Apgar Score; D001794:Blood Pressure / Q000187:drug effects; D002045:Bupivacaine / Q000009:adverse effects; D002585:Cesarean Section; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008012:Lidocaine / Q000009:adverse effects; D011247:Pregnancy; D011343:Procaine / Q000009:adverse effects / Q000031:analogs & derivatives; D011897:Random Allocation
D000779:Anesthetics, Local; D011343:Procaine; C004616:chloroprocaine; D008012:Lidocaine; D002045:Bupivacaine