title: Effects of anti-idiotypic immunizations on autoimmune uveitis induced with isologous lens proteins.
abstract: Autoimmune uveitis was induced in F1 hybrid rabbits by administering intramuscularly lens proteins in Freund's complete adjuvant. Cellular infiltration in the anterior chamber of the eye appeared in a cyclic manner and anti-lens protein antibody in the serum was mostly of oligoclonal origin, as assessed by isoelectric focusing analysis. Immunizations of such rabbits with autologous or isologous anti-lens protein antibody affected little the appearance of cellular infiltration upon rechallenge with lens proteins, but anti-lens protein antibody was replaced by other antibodies with different isoelectric points. Serum from these rabbits contained antibody which inhibited the antibody activity of certain anti-lens protein antibody.
mesh_terms: D000818:Animals; D000867:Anterior Chamber / Q000473:pathology; D000888:Antibodies, Anti-Idiotypic / Q000008:administration & dosage* / Q000032:analysis / Q000096:biosynthesis; D000917:Antibody Formation; D000961:Antilymphocyte Serum / Q000494:pharmacology; D001327:Autoimmune Diseases / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D003459:Crystallins / Q000276:immunology*; D007114:Immunization; D007130:Immunoglobulin Idiotypes / Q000235:genetics / Q000276:immunology*; D007249:Inflammation / Q000209:etiology / Q000276:immunology; D011817:Rabbits; D014605:Uveitis / Q000209:etiology / Q000276:immunology* / Q000473:pathology
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000961:Antilymphocyte Serum; D003459:Crystallins; D007130:Immunoglobulin Idiotypes