title: Radioimmunoassay for human pancreatic chymotrypsin and measurement of serum immunoreactive chymotrypsin contents in various diseases.
abstract: A radioimmunoassay for human pancreatic chymotrypsin II has been developed. Serum immunoreactive chymotrypsin II content in healthy individuals ranged from 14.7 ng/ml to 77.5 ng/ml, the average being 37.5 ng/ml (SD = 19.6). Elevated values were observed in patients with acute pancreatitis and renal failure. After total pancreatectomy, serum immunoreactive chymotrypsin II was not detectable. A significant positive correlation was observed between serum immunoreactive chymotrypsin II and cationic trypsin contents.
mesh_terms: D000918:Antibody Specificity; D002918:Chymotrypsin / Q000032:analysis* / Q000097:blood; D006801:Humans; D007676:Kidney Failure, Chronic / Q000201:enzymology; D010179:Pancreas / Q000201:enzymology*; D010182:Pancreatic Diseases / Q000201:enzymology; D011863:Radioimmunoassay / Q000379:methods; D013274:Stomach Neoplasms / Q000201:enzymology
chemical_list: D002918:Chymotrypsin