In vitro activity and beta-lactamase stability of a monobactam, SQ 26,917, compared with those of aztreonam and other agents.
SQ 26,917 is a monobactam antibiotic. Its in vitro activity was compared with those of aztreonam, cefotaxime, ceftazidime, and moxalactam. SQ 26,917, which contains a beta-methyl configuration on the beta-lactam ring, was similar in activity to aztreonam with the exception of greater activity against Pseudomonas aeruginosa isolates. SQ 26,917 had no activity against gram-positive isolates or anaerobic bacteria. It was not hydrolyzed by common plasmid and chromosomal beta-lactamases.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001398:Aztreonam; D001419:Bacteria / Q000187:drug effects*; D004355:Drug Stability; D008826:Microbial Sensitivity Tests; D011549:Pseudomonas / Q000187:drug effects; D013237:Stereoisomerism; D001618:beta-Lactamases / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D001618:beta-Lactamases; D001398:Aztreonam