Bronopol allergic contact dermatitis.
Bronopol (2-bromo-2-nitropropane-1, 3-diol) is an antimicrobial compound widely used as a preservative, primarily in cosmetic formulations. Analysis of patch tests performed on our patients revealed an incidence of 12.5% relevant positive results to 0.5% and/or 0.25% bronopol. This result reflects a history of prolonged use of bronopol-containing lubricants in our referral population of patients with different types of severe, extensive dermatitis. Contact sensitization to bronopol in this population is probably facilitated by abnormal cutaneous barrier function. Our findings emphasize the need for further clinical study of the potential for bronopol to produce contact sensitivity, and suggest caution with regard to its use in patients with dermatitis.
D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000378:metabolism / Q000633:toxicity*; D003877:Dermatitis, Contact / Q000175:diagnosis / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D010328:Patch Tests; D010592:Pharmaceutic Aids / Q000633:toxicity*; D011310:Preservatives, Pharmaceutical / Q000378:metabolism / Q000633:toxicity*; D011409:Propylene Glycols / Q000378:metabolism / Q000633:toxicity*; D012306:Risk
D000890:Anti-Infective Agents; D010592:Pharmaceutic Aids; D011310:Preservatives, Pharmaceutical; D011409:Propylene Glycols; C006827:bronopol