Resistance to trimethoprim-sulfamethoxazole in the treatment of Pneumocystis carinii pneumonia. Implication of folinic acid.
Pneumocystis carinii pneumonia is a well-known complication of immunosuppression in renal transplant recipients. Treatment is generally with trimethoprim-sulfamethoxazole (TMP-SMZ). A case of Pneumocystis pneumonia failed to respond to TMP-SMZ until concomitant administration of folinic acid was stopped. Physicians should be alerted to the possibility that folinic acid may impair the efficacy of TMP-SMZ in Pneumocystis carinii infection.
D004338:Drug Combinations / Q000627:therapeutic use; D004351:Drug Resistance; D006801:Humans; D002955:Leucovorin / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011020:Pneumonia, Pneumocystis / Q000188:drug therapy*; D013420:Sulfamethoxazole / Q000627:therapeutic use*; D014295:Trimethoprim / Q000627:therapeutic use*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole; D002955:Leucovorin