The acute action of fenbufen and piroxicam on the gastric mucosa as measured by gastric microbleeding.
The acute effect of a single dose of two non-steroidal anti-inflammatory drugs, fenbufen (Lederfen) and piroxicam, was tested on the human gastric mucosa for their ability to cause damage, as measured by microbleeding. In a volunteer trial in which twelve subjects took part, a single dose of 600 mg of fenbufen was compared with a placebo and a single dose of 20 mg of piroxicam on separate occasions. After taking the drugs, stomachs were aspirated via a nasogastric tube over the following 3 hours. When the haemoglobin in the aspirates was assayed it was concluded that fenbufen caused no more microbleeding than the placebo and less than that caused by piroxicam over the time period tested.
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000633:toxicity*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D010654:Phenylbutyrates; D010894:Piroxicam; D011422:Propionates / Q000633:toxicity*; D011897:Random Allocation; D013843:Thiazines / Q000633:toxicity*
D000893:Anti-Inflammatory Agents; D006454:Hemoglobins; D010654:Phenylbutyrates; D011422:Propionates; D013843:Thiazines; D010894:Piroxicam; C010725:fenbufen