title: The effect of coumarin derivatives on the immunological system of man.
abstract: Peripheral blood lymphocyte mitogen responsiveness was studied in 12 normal and 51 cancer patients. One group of patients was treated with warfarin, the second group with coumarin. There was a significant increase in lymphocyte response to phytohaemagglutinin (PHA) following both drugs. This increase indicates that both agents are capable of activating lymphocytes and thus stimulating some immunological functions.
mesh_terms: D003374:Coumarins / Q000494:pharmacology*; D006801:Humans; D007109:Immunity / Q000187:drug effects*; D009369:Neoplasms / Q000276:immunology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects; D014859:Warfarin / Q000494:pharmacology
chemical_list: D003374:Coumarins; D014859:Warfarin