Soluble peptidoglycan from Staphylococcus aureus is a murine B-lymphocyte mitogen.
Soluble peptidoglycan from Staphylococcus aureus has been shown to be capable of causing murine B lymphocytes from the spleen to proliferate and to secrete immunoglobulins in both an in vitro and an in vivo assay. The optimal concentration in vitro was between 33 and 100 micrograms/ml. A 3-day incubation with soluble peptidoglycan was more stimulatory than was a 1- or 2-day incubation. Removal of most of the T lymphocytes with anti-theta serum did not result in any significant change in the mitogenic activity of soluble peptidoglycan on the remaining B cells.
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D002455:Cell Division / Q000187:drug effects; D005260:Female; D007136:Immunoglobulins / Q000096:biosynthesis; D007700:Kinetics; D051379:Mice; D008815:Mice, Inbred Strains; D008837:Micrococcus; D008934:Mitogens / Q000494:pharmacology*; D010457:Peptidoglycan / Q000494:pharmacology*; D012995:Solubility; D013154:Spleen / Q000276:immunology; D013211:Staphylococcus aureus
D007136:Immunoglobulins; D008934:Mitogens; D010457:Peptidoglycan