Compound action potential input-output decruitment. Effect of topically applied antiseptics.
The ototoxic effect of povidone-iodine antiseptics topically applied to the chinchilla round window was examined with particular emphasis on the action potential (AP) input-output function at 2 and 4 kHz. A group of chinchillas exhibited a marked elevation of AP threshold at 8 and 12 kHz, with only a slight threshold elevation at 2 and 4 kHz. A distinct decruitment (less than normal growth of response with increasing sound intensity) of the AP input-output function was, however, found at the lower frequencies. There are implications of an ototoxically induced high-frequency hearing loss on speech frequencies.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002682:Chinchilla; D003051:Cochlea / Q000503:physiopathology*; D004594:Electrophysiology; D034381:Hearing Loss / Q000503:physiopathology*; D006316:Hearing Loss, High-Frequency / Q000139:chemically induced / Q000503:physiopathology*; D012001:Hyperacusis; D011205:Povidone / Q000031:analogs & derivatives*; D011206:Povidone-Iodine / Q000494:pharmacology*; D012405:Round Window, Ear / Q000503:physiopathology*
D011206:Povidone-Iodine; D011205:Povidone