Sprouting and regeneration of frog motoneurons during synapse elimination.
The ability of frog axons to sprout and reinnervate during the period of synapse elimination was examined in the cutaneous pectoris muscle from young postmetamorphic frogs using histological staining of nerve terminals and postsynaptic acetylcholinesterase. Partial denervation of the cutaneous pectoris muscle during the period of synapse elimination produced rapid sprouting of the intact axons. The majority of denervated endplates were being reinnervated by sprouts within 3 days. In addition, total denervation performed by either sectioning or crushing the nerve was followed by functional reinnervation. Approximately 98% of the endplates were being reinnervated within 7 days after a nerve crush and 10 days after sectioning the nerve.
D000375:Aging; D000818:Animals; D001369:Axons / Q000502:physiology; D008675:Metamorphosis, Biological; D009046:Motor Neurons / Q000502:physiology*; D009121:Muscle Denervation; D024510:Muscle Development; D009416:Nerve Regeneration; D011892:Rana catesbeiana; D013569:Synapses / Q000502:physiology*