Suppression of PHA-induced human T-lymphocyte colony formation following in vivo administration of anti-lymphocyte globulin. Report of one case.
The administration of anti-lymphocyte globulin in a patient with pure red cell aplasia completely abrogated the PHA-induced T colony forming capacity of peripheral blood mononuclear cells. The possible mechanisms of the ALG-induced suppression are discussed. It is proposed that T-colony assays may represent an useful tool for monitoring some effects of immunosuppressive drugs on T cells.
D000741:Anemia, Aplastic / Q000276:immunology; D000961:Antilymphocyte Serum / Q000276:immunology*; D003114:Colony-Forming Units Assay; D006801:Humans; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology*
D000961:Antilymphocyte Serum; D010835:Phytohemagglutinins