title: [Quantitative study of the morphofunctional changes in the placenta of rats exposed to nicotine at various periods of pregnancy].
abstract: Administration of 2% nicotine to Wistar rats in doses of 1.5 and 5 mg/kg produced functional disorders of the placenta over the entire pregnancy. From the 14th to the 21st day it retarded pregnancy, which at a dose of 1.5 mg/kg was made for by the increased area of the trophoblast elements.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D009538:Nicotine / Q000494:pharmacology*; D010920:Placenta / Q000187:drug effects* / Q000503:physiopathology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014327:Trophoblasts / Q000187:drug effects
chemical_list: D009538:Nicotine
vernacular_title: Kolichestvennoe izuchenie morfofunktsional'nykh izmeneniĭ platsenty krys, podvergshikhsia vozdeĭstviiu nikotina v raznye periody beremennosti.