Synthesis of some 3-hydroxynaphthalene-2-carbonylamino acid and dipeptide derivatives.
Synthesis of a series of 3-hydroxynaphthalene-2-carbonylamino acid methyl esters (II-XI) and some of their corresponding hydrazides (XII-XXI), dipeptide methyl esters (XXII-XXXV) and dipeptide hydrazides (XXXVI-XXXIX) is described. 3-Hydroxynaphthalene-2-CO-L-Tyr-N2H3 (XX) and the corresponding L-Val-L-Ala-N2H3 (XXXVI) were found to be active against a number of micro-organisms.
D000596:Amino Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004151:Dipeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D009284:Naphthols / Q000138:chemical synthesis* / Q000494:pharmacology
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D004151:Dipeptides; D009284:Naphthols