The risk of developing ankylosing spondylitis in HLA-B27 positive individuals: a family and population study.
In a family study, sacroiliitis was found in 15 (25%) out of 61 HLA-B27 positive first-degree relatives (FDR) of 20 randomly chosen HLA-B27 positive ankylosing spondylitis (AS) patients and never in 41 HLA-B27 negative FDR. Eight (53%) of the 15 FDR with sacroiliitis fulfilled the New York criteria for AS. In the population study the prevalence of HLA-B27 positive AS was found to be 0.1%. AS will develop in 1.3% of all HLA-B27 positive individuals belonging to the general population.
D000328:Adult; D005260:Female; D005828:Genetics, Population; D006680:HLA Antigens / Q000235:genetics*; D015796:HLA-B27 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D012306:Risk; D013167:Spondylitis, Ankylosing / Q000235:genetics* / Q000276:immunology
D006680:HLA Antigens; D015796:HLA-B27 Antigen