[Effect of novodrin on fatty acid oxidation by the myocardial mitochondria of white rats].
It has been shown in experiments on white rats that a single intraperitoneal injection of novodrine (1 mg/kg) stimulates respiration in myocardial mitochondria in a state of V0. Caprylate and palmitoyl carnitine were used as substrate. The drug reduces the rate of respiration in an active state so that the magnitude of respiratory control decreases. The VDNP rate increases during respiratory dissociation and phosphorylation. The novodrine-induced alterations in the functioning of electron transfer in myocardial mitochondria leads to the reduction of the synthesis of macroergic bonds in the form of ATP.
D000818:Animals; D004579:Electron Transport / Q000187:drug effects; D005227:Fatty Acids / Q000378:metabolism*; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology*; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats
D005227:Fatty Acids; D007545:Isoproterenol
Vliianie novodrina na okislenie zhirnykh kislot mitokhondriiami miokarda belykh krys.