Isolation and partial characterization of platelet aggregation inhibitors in the blood of dialyzed patients.
Platelet aggregation inhibitors were isolated from the blood of dialyzed patients by high-performance liquid chromatography. At least two inhibitors exist in the blood of dialyzed patients. These inhibitors not only inhibit platelet aggregation, but also suppress the chemiluminescence response of platelet. The chromatographic behaviors and the results of enzymatic digestion suggested that these inhibitors are relatively low molecular weight nonpeptidic substances.
D001792:Blood Platelets / Q000502:physiology; D006801:Humans; D008163:Luminescent Measurements; D010974:Platelet Aggregation / Q000187:drug effects*; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood* / Q000628:therapy