Dietary fat alters the fatty acid composition of lymphocyte membranes and the rate at which suppressor capacity is lost.
SJL/J mice were fed from conception two nutritionally adequate semi-purified diets that differed only in polyunsaturated to saturated fatty acid content. The effect of diet fat on the fatty acid composition of membranes from spleen and thymus cells was determined. Diet fat was found to significantly alter the fatty acid composition of lymphocyte membrane phosphatidylcholine and phosphatidylethanolamine. Diet also altered the degree of resistance against tolerance-induction.
D000818:Animals; D004041:Dietary Fats / Q000494:pharmacology*; D005227:Fatty Acids / Q000032:analysis; D005260:Female; D007108:Immune Tolerance; D008214:Lymphocytes / Q000032:analysis*; D008297:Male; D008563:Membrane Lipids / Q000032:analysis*; D051379:Mice; D010713:Phosphatidylcholines / Q000032:analysis; D010714:Phosphatidylethanolamines / Q000032:analysis; D010743:Phospholipids / Q000032:analysis*; D013154:Spleen / Q000166:cytology; D013950:Thymus Gland / Q000166:cytology
D004041:Dietary Fats; D005227:Fatty Acids; D008563:Membrane Lipids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010743:Phospholipids