title: [Activation of natural killers (NK cells) in normal Syrian hamsters and tumor-bearing hamsters by the Newcastle disease virus].
abstract: Natural cytotoxicity of non-adherent lymphoid spleen cells from random-bred Syrian hamsters was demonstrated in the cytotoxic test in vitro with the use of xenogeneic human myeloma target cells (strain K-562) labeled with 51Cr. Cytotoxic natural killers (NK) could be isolated in the Ficoll gradient of 1.078 density, selective for large granular lymphocytes. The maximal lytic activity of NK was observed in the cytotoxic test in vitro after 10-12-hour contact with sensitive K-562 target cells. The highest NK activity was observed in blood and spleen cells. In bone marrow and thymic cells, it was less potent. NK activity was almost absent from peripheral lymph nodes.
mesh_terms: D000818:Animals; D006224:Cricetinae; D003601:Cytotoxicity Tests, Immunologic; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000276:immunology*; D009522:Newcastle disease virus / Q000276:immunology*
vernacular_title: Aktivatsiia normal'nykh killerov (NK-kletok) normal'nykh siriĭskikh khomiakov i khomiakov-nositeleĭ opukholeĭ virusom bolezni N'iukasla.