Maturational and degenerative processes in the organ of Corti after neonatal hypothyroidism.
In order to study the long-term effects of neonatal hypothyroidism on the organ of Corti, rats were given propylthiouracil (PTU) during the first 30 days after birth. Cochlear changes occurring after the cessation of antithyroid treatment were studied by both physiological (brainstem auditory evoked responses: BAERs, electrocochleography) and morphological techniques (transmission and scanning electron microscopy). The first appearance of BAERs was noted between days 37 and 45. Maturation of auditory potentials was achieved within 10-15 days but was incomplete since the animals definitely demonstrated elevated thresholds around 60-70 dB SPL. Morphological results indicated that some structures, like the inner sulcus epithelium, were able to restart maturational processes that had been interrupted during the period of hypothyroidism. However, these maturational changes were considerably limited and rapidLy accompanied by severe degenerative changes involving almost all cochlear structures. Degenerative changes included the deposition of an amorphous substance within the organ of Corti, severe alterations in pillar cells (absence of formation of the tunnel of Corti, distortion of microtubules), severe outer hair cell losses with abnormalities in their innervation (absence of development of efferents and loss of afferent dendrites).
D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D004594:Electrophysiology; D007037:Hypothyroidism / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D009925:Organ of Corti / Q000254:growth & development* / Q000473:pathology; D011441:Propylthiouracil / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
D011441:Propylthiouracil