[Carcinogenesis in rats under the combined transplacental action of sex hormones and nitrosoethylurea].
Transplacental treatment with synestrol exerted a slight modifying effect on nitrosoethylurea-induced carcinogenesis in random-bred albino rats: prenatal treatment with synestrol reduced the rates of Leydig-cell and uterine tumor incidence to those of spontaneous tumors.
D000310:Adrenal Gland Neoplasms / Q000139:chemically induced; D000818:Animals; D004028:Dienestrol / Q000494:pharmacology; D004357:Drug Synergism; D005038:Ethylnitrosourea / Q000037:antagonists & inhibitors; D005260:Female; D005333:Fetus / Q000187:drug effects*; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D007984:Leydig Cell Tumor / Q000139:chemically induced; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009423:Nervous System Neoplasms / Q000139:chemically induced; D009607:Nitrosourea Compounds / Q000037:antagonists & inhibitors; D010051:Ovarian Neoplasms / Q000139:chemically induced; D011247:Pregnancy; D051381:Rats; D012513:Sarcoma, Experimental / Q000139:chemically induced; D013736:Testicular Neoplasms / Q000139:chemically induced; D013739:Testosterone / Q000494:pharmacology; D013964:Thyroid Neoplasms / Q000139:chemically induced; D014594:Uterine Neoplasms / Q000139:chemically induced
D012739:Gonadal Steroid Hormones; D009607:Nitrosourea Compounds; D013739:Testosterone; D005038:Ethylnitrosourea; D004028:Dienestrol
Kantserogenez u krys pri kombinirovannom transplatsentarnom vozdeĭstvii polovyk gormonov i nitrosoétilmocheviny.