Effects of fenbufen, indomethacin, naproxen, and placebo on gastric mucosa of normal volunteers. A comparative endoscopic and photographic evaluation.
The effects of fenbufen (1,000 mg a day), indomethacin (150 mg a day), naproxen (750 mg a day), and placebo on gastric mucosa were determined by endoscopy and recorded photographically. One hundred normal subjects, randomly divided into equal, parallel-treatment groups, were given the drugs in divided daily doses for seven consecutive days. The results revealed that the effects of fenbufen on gastric mucosa were significantly (p less than or equal to 0.05) less than those of either naproxen or indomethacin and not statistically different from those observed with placebo.
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000633:toxicity*; D002214:Capsules; D004341:Drug Evaluation; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D005773:Gastroscopy; D006801:Humans; D007213:Indomethacin / Q000633:toxicity*; D008297:Male; D009288:Naproxen / Q000633:toxicity*; D010654:Phenylbutyrates; D010919:Placebos; D011422:Propionates / Q000633:toxicity*; D013276:Stomach Ulcer / Q000139:chemically induced; D013607:Tablets
D000893:Anti-Inflammatory Agents; D002214:Capsules; D010654:Phenylbutyrates; D010919:Placebos; D011422:Propionates; D013607:Tablets; D009288:Naproxen; C010725:fenbufen; D007213:Indomethacin