title: Temocillin in peripheral lymph.
abstract: One gram of temocillin was given intravenously to five healthy volunteers to study the concentrations in serum and peripheral lymph obtained by cannulation of the lower leg. The 1 h serum level was 58.1 mg/l and the lymph level 14.3 mg/l. The mean peak lymph concentration was 30.6 mg/l and occurred between 1.5 and 2 h; the simultaneous serum level was 47.8 mg/l. The antibiotic levels in lymph were always below those in serum. The urinary recovery over 12 h was nearly 60%. The mean ratio between the areas under the concentration curves of lymph and serum was 0.558. The serum half-life was 4.9 h, the apparent beta-phase distribution volume 18.41. In comparison, the lymph half-life was 4.4 h. Protein binding appears to be of little consequence to the ability of temocillin to penetrate well into extravascular foci.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008196:Lymph / Q000378:metabolism*; D008297:Male; D010406:Penicillins / Q000378:metabolism*
chemical_list: D010406:Penicillins; C031367:temocillin