Pharmacokinetic analysis of the level of sulfonamide-trimethoprim combination in calves.
Pharmacokinetic parameters which describe biological availability (AUC, Cmax, tmax) and elimination (kel, t 1/2) of sulfonamides and trimethoprim were determined in calves. Pharmacokinetic analysis was based upon "one compartment model". The average +/- SD half-life in plasma was for sulfametoxazole 12.8 +/- 0.32 h, for sulfamerazine 17.0 +/- 0.75 h and for sulfachloropyridazine 13.1 +/- 0.86 h. The average half-life of trimethoprim in plasma was 11.3 +/- 0.56 h. In fasted calves the concentrations of sulfachloropyridazine and trimethoprim in plasma were higher as compared with fed group.
D000818:Animals; D000892:Anti-Infective Agents, Urinary / Q000378:metabolism; D002417:Cattle; D004338:Drug Combinations / Q000378:metabolism; D007700:Kinetics; D013410:Sulfachlorpyridazine / Q000378:metabolism; D013411:Sulfadiazine / Q000378:metabolism; D013416:Sulfamerazine / Q000378:metabolism; D013420:Sulfamethoxazole / Q000378:metabolism; D013449:Sulfonamides / Q000378:metabolism*; D014295:Trimethoprim / Q000378:metabolism*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D000096926:Benzenesulfonamides
D000892:Anti-Infective Agents, Urinary; D004338:Drug Combinations; D013410:Sulfachlorpyridazine; D013411:Sulfadiazine; D013416:Sulfamerazine; D013420:Sulfamethoxazole; D013449:Sulfonamides; D014295:Trimethoprim; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; C024873:sulfadiazine, trimethoprim drug combination; D000096926:Benzenesulfonamides