Effects of synthetic steroid contraceptives on biliary lipid composition of normal Mexican women.
The effects of two hormonal contraceptives upon the biliary lipid composition of Mexican women were evaluated in a prospective study. Twenty-one healthy volunteers of reproductive age were allocated into three groups (7 subjects each). Group I served as the experimental control (all subjects were bearing a non-medicated IUD), group II received i.m. norethisterone enanthate (NET-e) 200 mg every two months, and group III received an oral combination of 1-norgestrel 150 micrograms and ethinyl estradiol 30 micrograms. The bile lithogenic index as assessed by the relative proportion of cholesterol to bile acids and lecithin was determined in duodenal bile samples obtained before (baseline), during (4 months), and after (12 months) contraceptive administration. The results indicated that NET-e administration resulted in a slight although significant increase of the lithogenic index while the oral formulation did not. The overall data were interpreted as demonstrating that administration of these steroid contraceptives does not constitute a risk factor in terms of gallstone formation in the population studied. The estrogen-like behavior exhibited by NET-e is discussed.
D000328:Adult; D001646:Bile / Q000032:analysis*; D001647:Bile Acids and Salts / Q000032:analysis*; D002784:Cholesterol / Q000032:analysis; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D006801:Humans; D008055:Lipids / Q000032:analysis*; D008800:Mexico; D009640:Norethindrone / Q000031:analogs & derivatives* / Q000494:pharmacology; D009644:Norgestrel / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000032:analysis; D011446:Prospective Studies; D011897:Random Allocation
D001647:Bile Acids and Salts; D003276:Contraceptives, Oral; D003280:Contraceptives, Oral, Synthetic; D008055:Lipids; D010713:Phosphatidylcholines; D009644:Norgestrel; D004997:Ethinyl Estradiol; D002784:Cholesterol; C024319:norethindrone enanthate; D009640:Norethindrone