title: Low concentrations of trifluoperazine affect striatal cells in culture.
abstract: Primary monolayer cultures of the newborn rat corpus striatum were treated with the phenothiazine trifluoperazine after various times in culture. When the drug is added to cells at least 3 weeks old, concentrations of 10(-7) and 10(-8) M appear morphologically identical to controls but show significant changes in synthesis of acetylcholine and gamma-aminobutyric acid, particularly the former. The results with these very low concentrations suggest that the drug has a highly specific effect directly on striatal cells, and that it is not acting via calmodulin.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D002794:Choline / Q000378:metabolism; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003342:Corpus Striatum / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005968:Glutamate Decarboxylase / Q000378:metabolism; D051381:Rats; D014268:Trifluoperazine / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
chemical_list: D014268:Trifluoperazine; D005680:gamma-Aminobutyric Acid; D002795:Choline O-Acetyltransferase; D005968:Glutamate Decarboxylase; D002794:Choline