[Therapy of acute esophageal varices hemorrhage. Animal-experiment and clinical results].
Next to the operative therapy of portal hypertension during non bleeding intervals using the various portacaval shunts, sclerotherapy is being chosen more and more especially in the acute phase. In this animal experiment the hemodynamics of vasopressin were compared to those of the derivative, TGLVP, with prolonged action. While both showed the same effect on the hemodynamics, the TGLVP treatment hardly changed the oxygen supply to the liver. However, vasopressin treatment lowered the pO2 in the liver significantly. We never saw negative side effects. Therefore we recommend TGLVP to support sclerotherapy during acute bleeding of esophageal varices.
D000208:Acute Disease; D000818:Animals; D004285:Dogs; D004932:Esophageal and Gastric Varices / Q000150:complications* / Q000188:drug therapy; D006471:Gastrointestinal Hemorrhage / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006975:Hypertension, Portal / Q000188:drug therapy; D008102:Liver Circulation / Q000187:drug effects; D008236:Lypressin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D010100:Oxygen / Q000097:blood; D012597:Sclerosing Solutions / Q000627:therapeutic use; D000077585:Terlipressin
D012597:Sclerosing Solutions; D008236:Lypressin; D000077585:Terlipressin; D010100:Oxygen
Therapie der akuten Osophagusvarizenblutung. Tierexperimentelle und klinische Ergebnisse.