title: Total, dialyzable, and nondialyzable postabsorptive hydroxyproline. Values in patients with cancer.
abstract: The postabsorptive urinary total (T), dialyzable (D), and nondialyzable (ND) hydroxyproline (HYPRO) tests were evaluated to determine whether the patterns of excretion varied according to the predominance of osteoblastic v osteolytic bone involvement in 58 patients with neoplastic disease. In patients with osteolytic lesions from multiple myeloma, elevated T and D levels with normal ND HYPRO values were observed, along with elevated D/ND ratios. In prostate cancer, the T, D, and ND values were all elevated and the D/ND ratio was normal. Patients with Hodgkin's disease had elevated T, D, and ND HYPRO levels, and the D/ND ratio was in the range of patients with prostate cancer. The data suggest that these collagen markers may be useful in the long-term evaluation of these neoplasms in patients.
mesh_terms: D001859:Bone Neoplasms / Q000556:secondary / Q000652:urine*; D001943:Breast Neoplasms; D003094:Collagen / Q000652:urine; D003956:Dialysis; D005260:Female; D006689:Hodgkin Disease / Q000556:secondary*; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D008297:Male; D009101:Multiple Myeloma / Q000556:secondary*; D011471:Prostatic Neoplasms
chemical_list: D003094:Collagen; D006909:Hydroxyproline