title: The cell population of cutaneous B-cell lymphomas.
abstract: The cellular composition of the dermal infiltrates of eleven patients with a cutaneous B-cell lymphoma (four centroblastic lymphomas, two centroblastic/centrocytic lymphomas and five immunocytomas) was investigated. The distribution of both the neoplastic and the non-neoplastic cells (reactive T cells, macrophages and dendritic reticulum cells) in primary and secondary cutaneous B-cell lymphomas was very similar to that of B-cell lymphomas of the same type in lymph nodes. Reactive T cells and dendritic reticulum cells were only occasionally found in centroblastic lymphoma, but were very numerous in centroblastic/centrocytic lymphoma. The large majority of these T cells in centroblastic/centrocytic lymphoma showed the phenotype of activated T-helper cells (Leu-I+, Leu-3a+, OKT4+, HLA-DR+). In immunocytomas many T cells reactive with Leu-I, Leu-3a, and OKT4 but not with anti-HLA-DR antiserum, and varying numbers of dendritic reticulum cells were found. Since B-cell lymphomas in lymph nodes are the neoplastic counterparts of B-cell reactions which take place after antigenic stimulation in the different lymph node compartments, our results suggest that cutaneous B-cell lymphomas may be the malignant counterparts of similar B-cell reactions in the skin.
mesh_terms: D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000276:immunology / Q000473:pathology; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*
chemical_list: D000911:Antibodies, Monoclonal