title: [Benzo(a)pyrene hydroxylase activity of immunocompetent cells].
abstract: A study was made of aryl hydrocarbon hydroxylase activity in immunocompetent cells of varying origin and in hepatocytes from CBA mice. The cells from intact animals may be arranged in the following way with regard to the activity of the enzyme: macrophages greater than hepatocytes much greater than thymocytes greater than splenocytes. The immunostimulants (tilorone and its analogs) altered benzo(a)pyrene hydroxylase activity depending on the cell type.
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D001572:Benzofurans / Q000494:pharmacology; D001579:Benzopyrene Hydroxylase / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008264:Macrophages / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000187:drug effects / Q000201:enzymology*; D013601:T-Lymphocytes / Q000187:drug effects / Q000201:enzymology*; D013994:Tilorone / Q000494:pharmacology / Q000031:analogs & derivatives
chemical_list: D000276:Adjuvants, Immunologic; D001572:Benzofurans; C038399:IS 23; C038900:IS 33; D001579:Benzopyrene Hydroxylase; D001189:Aryl Hydrocarbon Hydroxylases; D013994:Tilorone
vernacular_title: Benz(a)pirengidroksilaznaia aktivnost' immunokompetentnykh kletok.