[Is the HLA-DR associated glycoprotein p31 a ubiquitous molecule?].
The glycoprotein p31 (also called Ii, In, M1, Dr gamma, XM 1) has been shown up to now only in the membranes of B lymphocytes as well as of epidermal and endothelial cells, where it is always accompanied by antigens of the HLA-DR type. It is therefore called HLA-DR-associated protein. As we show here, the membranes of muscle, liver and brain contain protein molecules with the relative molecular mass Mr = 31 000-33 000 and an isoelectric point around 7.5. These parameters correspond to those of the p31 of B lymphocytes. These molecules, as well as the p31 of B lymphocytes, can be concentrated by ion exchange chromatography. In two-dimensional electropherograms they are identical to those of B lymphocytes. It can therefore be assumed that the po 31 is not really associated with the HLA-DR antigens but is a ubiquitous molecule.
D001402:B-Lymphocytes / Q000276:immunology; D001921:Brain / Q000276:immunology; D002462:Cell Membrane / Q000276:immunology; D004591:Electrophoresis, Polyacrylamide Gel; D004727:Endothelium / Q000276:immunology; D006023:Glycoproteins / Q000032:analysis*; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D006801:Humans; D008099:Liver / Q000276:immunology; D008562:Membrane Glycoproteins; D008970:Molecular Weight; D009132:Muscles / Q000276:immunology; D046988:Proteasome Endopeptidase Complex; D011506:Proteins / Q000032:analysis*; D012867:Skin / Q000276:immunology; D014018:Tissue Distribution
D006023:Glycoproteins; D006684:HLA-DR Antigens; D000949:Histocompatibility Antigens Class II; D008562:Membrane Glycoproteins; C501479:PSMD8 protein, human; D011506:Proteins; C035572:XM1 protein, human; D046988:Proteasome Endopeptidase Complex
Ist das HLA-DR-assoziierte Glycoprotein p31 ein ubiquitäres Molekül?