Human chromosome 11 carries at least four genes controlling expression of cell-surface antigens.
We have mapped two new genes to chromosome 11 which control the cell-surface expression of two distinct antigens defined by monoclonal antibodies. One of the antigens has a general tissue distribution and is associated with a molecular complex of two polypeptides of 80,000 dalton and 40,000 dalton molecular weight. The second antigen has a restricted tissue distribution and is carried on a polypeptide of 100,000 daltons. We have used a combination of genetic and biochemical techniques to demonstrate that these new markers are distinct from the antigens defined by the monoclonal antibodies F10.44.2 and W6/34 which are also encoded by genes on chromosome 11. It is concluded that human chromosome 11 carries at least four distinct genes controlling cell-surface antigen expression.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis; D000954:Antigens, Surface / Q000032:analysis / Q000235:genetics*; D002460:Cell Line; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X / Q000648:ultrastructure*; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D006822:Hybrid Cells / Q000276:immunology / Q000648:ultrastructure; D051379:Mice; D008970:Molecular Weight
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface