Liposomes inhibit intercellular attachment.
Phosphatidylcholine liposomes bound to the surface of L cells inhibit cell attachment to L-cell monolayers or to lipid films. Aggregation of L cells or of mouse embryo fibroblasts is also diminished upon treatment with liposomes. However, they neither inhibit cell attachment to glass or cellulose acetate substrata, nor diminish conA-mediated cell aggregation. It is supposed that liposome-binding sites on the cell surface described earlier are involved in cell-cell attachment.
D000818:Animals; D002450:Cell Communication / Q000187:drug effects*; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000502:physiology; D007365:Intercellular Junctions / Q000187:drug effects / Q000502:physiology*; D007700:Kinetics; D007739:L Cells / Q000502:physiology; D008081:Liposomes; D051379:Mice; D010713:Phosphatidylcholines / Q000494:pharmacology*
D008081:Liposomes; D010713:Phosphatidylcholines; D003208:Concanavalin A