Tolerance to amoxapine antidepressant effects.
Several patients treated with amoxapine (in dosages ranging from 50 to 300 mg/day) had excellent initial responses followed by relapse unresponsive to dose adjustment, suggesting pharmacological tolerance to its antidepressant effect.
D000328:Adult; D000368:Aged; D000657:Amoxapine / Q000008:administration & dosage / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy*; D003989:Dibenzoxazepines / Q000627:therapeutic use*; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D003989:Dibenzoxazepines; D000657:Amoxapine