Antipyretic analgesic drugs as models for studies of drug disposition in old age.
Alterations in drug metabolizing capacity associated with the aging process can be elucidated using analgesic-antipyretic agents as model compounds. Antipyrine serves to profile drug oxidizing capacity. Drug oxidation is significantly impaired in old age, but age-related changes are far greater in men than in women. Acetaminophen analogously serves to profile conjugating capacity, which is minimally influenced by age both in men and in women. Changes in the capacity to biotransform these model compounds are reasonably well predictive of parallel changes in the same person's ability to metabolize other drugs transformed by the same pathway.
D000082:Acetaminophen / Q000378:metabolism; D000368:Aged; D000375:Aging; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000378:metabolism*; D000983:Antipyrine / Q000378:metabolism; D001711:Biotransformation; D005260:Female; D006801:Humans; D008297:Male; D008954:Models, Biological; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004364:Pharmaceutical Preparations; D000082:Acetaminophen; D000983:Antipyrine