[Intracellular La3+-resistant calcium pools in the blood vessels and hearts of rats with spontaneous hypertension].
A significant increase was demonstrated in the capacity of intracellular La3+-resistant calcium pools with high affinity to calcium in the aorta, tail artery and left ventricle of spontaneously hypertensive rats (SHR), while low-affinity pools were only increased in SHR vessels. Rates of 45Ca metabolism in low- and high-affinity pools were significantly higher in SHR aortas as compared to the controls. Increased levels of intracellular metabolizing calcium and its abnormal vascular and heart transport in SHR can account for enhanced reactivity of these tissues and increased peripheral vascular resistance in arterial hypertension.
D000818:Animals; D001011:Aorta / Q000378:metabolism; D001158:Arteries / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002463:Cell Membrane Permeability; D005260:Female; D006973:Hypertension / Q000378:metabolism*; D007424:Intracellular Fluid / Q000378:metabolism; D007811:Lanthanum / Q000494:pharmacology*; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D013623:Tail / Q000098:blood supply
D007811:Lanthanum; D002118:Calcium
Vnutrikletochnye La3+-rezistentnye puly kal'tsiia v sosudakh i serdtse krys so spontannoĭ gipertenzieĭ.