A study of mechanisms of post-irradiation changes in adenylate-cyclase activity.
Hormone-stimulated adenylate-cyclase activity (via beta-adrenergic receptors) is reduced after in vitro irradiation of plasma membranes of frog erythrocytes, at a dose (650 Gy) which does not change the number of beta-adrenergic receptors but causes an oxidative degradation of membrane lipids. Peroxidation of membrane lipids without irradiation also results in a lesser stimulation of adenylate cyclase by the beta-agonist. A possible mechanism of change in adenylate-cyclase functioning is discussed.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D004082:Dihydroalprenolol / Q000494:pharmacology; D004307:Dose-Response Relationship, Radiation; D004910:Erythrocyte Membrane / Q000378:metabolism / Q000528:radiation effects*; D004912:Erythrocytes / Q000528:radiation effects*; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D008054:Lipid Peroxides / Q000378:metabolism; D008563:Membrane Lipids / Q000378:metabolism; D011896:Rana temporaria; D012969:Sodium Fluoride / Q000494:pharmacology; D013268:Stimulation, Chemical
D008054:Lipid Peroxides; D008563:Membrane Lipids; D004082:Dihydroalprenolol; D012969:Sodium Fluoride; D000262:Adenylyl Cyclases; D007545:Isoproterenol