[Status of cerebral capillary circulation during ischemia with barbiturate protection].
Experiments on 78 albino rats with ligated common carotid arteries were carried out to study the effect of a barbiturate agent (barbamil) administered in a dose of 150 mg/kg of animal body weight on cerebral capillary circulation at different terms of ischemia (1, 3 hours, 1, 3, 7, 14 days). The findings obtained during follow-up point to a beneficial effect of the barbiturate on the structures of the capillary wall (endotheliocytes, pericytes, basal membrane). Furthermore, the drug appears to maintain the capillary lumen and the normal level of capillary permeability, which contributes to the improvement of microcirculation in ischemia. The paper also describes some ultrastructural mechanisms of the decrease and stabilization of the cerebral capillary blood flow under the barbiturate impact due to endothelial synapses blockade, inhibition of vasoconstrictive mechanisms and stabilization of the membrane structures of the capillary network.
D000654:Amobarbital / Q000627:therapeutic use*; D000818:Animals; D002545:Brain Ischemia / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D002196:Capillaries / Q000473:pathology; D002199:Capillary Permeability; D002540:Cerebral Cortex / Q000098:blood supply*; D008854:Microscopy, Electron; D009457:Neuroglia / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D000654:Amobarbital
Sostoianie kapilliarnogo krovoobrashcheniia mozga pri ishemii v usloviiakh barbituratnoĭ zashchity.