Polymorphonuclear cell motility, ankylosing spondylitis, and HLA B27.
Polymorphonuclear leucocyte (PMN) function was studied in 29 subjects with ankylosing spondylitis (AS). Of these, 20 were HLA B27+ve and 9 B27-ve. There were 30 controls and, of these, 15 were B27+ve. Random and directed cell migration was measured by 2 techniques: migration through a micropore filter and migration under an agar film. The chemo-attractant was either case in-activated serum or zymosan-activated serum. By both techniques directed motility was increased in subjects with B27 or with AS when compared to the B27-ve controls. This suggests that the disease AS and the possession of B27 are both associated with increased PMN motility.
D000328:Adult; D002448:Cell Adhesion; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015796:HLA-B27 Antigen; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000502:physiology*; D010587:Phagocytosis; D013167:Spondylitis, Ankylosing / Q000097:blood / Q000276:immunology*
D006680:HLA Antigens; D015796:HLA-B27 Antigen