[Recent immunobiochemical advances on the function of the immune system of the mucous membrane in the gastrointestinal tract].
In the mucous membrane of the gastro-intestinal canal large quantities of T- and B-lymphocytes appear which are in constant renovation. The lymphocytes situated intraepithelially and in the lamina propria have a contact with the antigens touching the mucous membrane or taken into it (alimentary proteins, bacteria, viruses, protozoa), by means of which a more or less important evocation of immune reactions is brought about. IgA-molecules formed by plasma cells of the mucous membrane are given into the lumen and there they bind antigens, by means of which these are prevented from the connection with the epithelial cells. A part of the IgA-molecules is transported into the liver via the blood plasma and the lymph, respectively, where a destruction of the antigen-IgA-complexes takes place. The IgA-molecules are excreted via the bile into the intestine. Under certain conditions an allergy against alimentary proteins (lactoprotein, egg white protein, cereal protein) develops. Lymphocytes carried off from the intestinal canal settle in other tissues and may mediate "immunological experience", which is particularly of importance in the milk secretion.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002417:Cattle; D003126:Colostrum / Q000032:analysis; D004044:Dietary Proteins / Q000378:metabolism; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology; D006098:Granulocytes / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology; D007413:Intestinal Mucosa / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D008895:Milk, Human / Q000032:analysis; D011247:Pregnancy; D013601:T-Lymphocytes / Q000276:immunology
D004044:Dietary Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G
Neuere immunbiochemische Erkenntnisse zur Funktion des Immunsystems in der Schleimhaut des Magen-Darm-Kanals.