title: Effect of occupational exposure to epichlorohydrin on the frequency of chromosome aberrations in peripheral lymphocytes.
abstract: The relationship between the level of occupational exposure to epichlorohydrin (ECHH) and the clastogenic effect was studied on a group of 33 workers. The effect of ECHH was assessed by differences in the frequency of chromosome aberrations in peripheral blood lymphocytes in ECHH-exposed and control groups. In the group exposed to the average ECHH concentration, 0.384 mg X m-3, during the last 6 months, the cytogenetic analysis revealed 2.00 +/- 0.23% AC (aberrant cells) (0.0203 B/C, breaks per cell) as compared with 1.68 +/- 0.23% AC (0.0172 B/C) in the matching controls. These results indicate that an average concentration lower than 0.40 mg X m-3 ECHH in the working atmosphere has no significant clastogenic effect on human peripheral lymphocytes.
mesh_terms: D000328:Adult; D002728:Chlorohydrins / Q000009:adverse effects*; D002869:Chromosome Aberrations; D004781:Environmental Exposure; D004811:Epichlorohydrin / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male
chemical_list: D002728:Chlorohydrins; D004811:Epichlorohydrin