Scanning electron microscopic (SEM) studies on the effect of x-ray contrast media on aortic endothelium in the rat.
A study comparing the effects of diatrizoate, ioxitalamate, metrizamide, ioxaglate, and a 22% sorbitol on aortic endothelia of the rat was performed. In each case 1 ml of the respective solution was injected in a single dose into the aorta. Endothelial damage was seen after injection of metrizamide, diatrizoate, and ioxitalamate. After injection of ioxaglate or sorbitol, only minor endothelial changes were observed.
D000818:Animals; D001011:Aorta / Q000187:drug effects* / Q000648:ultrastructure; D003287:Contrast Media / Q000633:toxicity*; D003973:Diatrizoate / Q000633:toxicity; D007463:Iodobenzoates / Q000633:toxicity*; D007483:Iothalamic Acid / Q000031:analogs & derivatives / Q000633:toxicity; D007485:Ioxaglic Acid; D008297:Male; D008793:Metrizamide / Q000633:toxicity; D008855:Microscopy, Electron, Scanning; D009994:Osmolar Concentration; D051381:Rats; D014283:Triiodobenzoic Acids / Q000633:toxicity*
D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; D007483:Iothalamic Acid; C002587:ioxitalamic acid; D008793:Metrizamide; D007485:Ioxaglic Acid