Serum lipase, isoamylase and pancreatic function test (PFT) in juvenile-onset insulin-dependent diabetes mellitus.
Significantly decreased activity of pancreatic isoamylase in serum was found in a group of 51 juvenile-onset insulin-dependent diabetics as compared to healthy subjects (p less than 0.005). No significant changes were observed for urinary p-aminobenzoic acid excretion in 20 of the juvenile-onset diabetics in whom the NBT-PABA test was performed, even though 25% of the values were below the normal limit. A highly significant decrease of serum lipase activity was found in juvenile-onset diabetics as compared to controls (p less than 0.001). No significant correlation was found in juvenile-onset diabetics between serum pancreatic isoamylase and lipase or marker of chymotrypsin activity expressed as the amount of p-aminobenzoic acid excreted into urine. The NBT-PABA test appears to be of small importance in the evaluation of changes of the exocrine pancreas in insulin-dependent diabetes mellitus. However, simultaneous evaluation of serum pancreatic isoamylase and lipase activities justified the suspicion of pancreatic damage in 50% of the patients tested.
D010129:4-Aminobenzoic Acid / Q000652:urine; D000328:Adult; D003922:Diabetes Mellitus, Type 1 / Q000201:enzymology* / Q000503:physiopathology; D005260:Female; D006026:Glycoside Hydrolases / Q000097:blood*; D006801:Humans; D007517:Isoamylase / Q000097:blood*; D008049:Lipase / Q000097:blood*; D008297:Male; D010179:Pancreas / Q000503:physiopathology*; D010186:Pancreatic Function Tests; D062366:para-Aminobenzoates
D062366:para-Aminobenzoates; C006717:bentiromide; D008049:Lipase; D006026:Glycoside Hydrolases; D007517:Isoamylase; D010129:4-Aminobenzoic Acid