The cold-induced TSH secretion is resistant to alterations in the physicochemical properties of the intracerebral infusions.
The purpose of the present study was to see how different methodological factors affect TSH secretion in male rats. The cold-induced TSH secretion was rather resistant to variations in the volume, pH and osmolality of solutions infused bilaterally into the anterior hypothalamus or into the 3rd ventricle of the rat brain. Only rather high pH (11.30) and osmolality (870 mosmol/kg) significantly inhibited the TSH cold-response. A short term immobilization (sham-infusion) or ether anaesthesia did not cause any significant alterations in TSH secretion. It is concluded that the cold-induced TSH secretion is not easily affected by nonspecific methodological factors.
D000818:Animals; D003080:Cold Temperature; D006863:Hydrogen-Ion Concentration; D007032:Hypothalamus, Anterior / Q000502:physiology*; D007267:Injections; D007276:Injections, Intraventricular; D008297:Male; D008722:Methods; D008845:Microinjections; D009994:Osmolar Concentration; D051381:Rats; D011919:Rats, Inbred Strains; D013972:Thyrotropin / Q000378:metabolism*
D013972:Thyrotropin