A new synthesis of bis(diacylglycero)phosphate.
The chemical synthesis of bis(diacylglycero) phosphate previously named bisphosphatidic acid, starting with a diacylglycerol and phosphatidic acid, is described. The phosphodiester bond formation is catalyzed by triisopropylbenzenesulfonylchloride. This simple approach allows the preparation of saturated as well as unsaturated bis(diacylglycero)phosphate species in one step without the use of any protecting group. The methods used until now yield only mono-acid species, or mixed-acid unsaturated species after many steps involving the introduction and the removal of protecting groups. The synthetic products have been characterized by component analysis and NMR-techniques.
D002384:Catalysis; D007536:Isomerism; D010712:Phosphatidic Acids / Q000138:chemical synthesis*
D010712:Phosphatidic Acids; C021632:bisphosphatidic acid