[Use of antioxidants to prevent damage during acute ischemia and reperfusion of the kidneys].
Prophylactic injection of the natural antioxidant alpha-tocopherol and synthetic antioxidants ionol, diludin and 6-mercurascan prevented the development of lesions during acute renal ischemia and subsequent reperfusion. Ionol proved more effective on intraperitoneal injection than on intragastric route of administration. It has been demonstrated that antiischemic effect of ionol is related to its ability to exhibit the process of lipid peroxidation.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use; D003997:Dicarbethoxydihydrocollidine / Q000031:analogs & derivatives / Q000627:therapeutic use; D005452:Fluoresceins / Q000627:therapeutic use; D007511:Ischemia / Q000188:drug therapy*; D007668:Kidney / Q000098:blood supply*; D008297:Male; D009941:Organomercury Compounds / Q000627:therapeutic use; D051381:Rats; D014810:Vitamin E / Q000627:therapeutic use
D000975:Antioxidants; D005452:Fluoresceins; D009941:Organomercury Compounds; C015160:etidin; D014810:Vitamin E; D002084:Butylated Hydroxytoluene; C010604:mercurascan; D003997:Dicarbethoxydihydrocollidine
Primenenie antioksidantov dlia profilaktiki povrezhdeniĭ pri ostroĭ ishemii i reperfuzii pochek.