Genotoxicity of quinone pigments from pathogenic fungi.
The genotoxicity and mutagenicity of several kinds of quinone pigments from pathogenic fungi were examined by means of the hepatocyte primary culture (HPC)/DNA repair test and of Ames test with TA98 and TA100. Clear genotoxicity of the two quinone chemicals, xanthomegnin and luteosporin were observed in the HPC/DNA repair test, though definite mutagenicity was not detected in the Salmonella microsome test. These two pigments are thus suspected to be genotoxic carcinogens.
D000818:Animals; D004260:DNA Repair / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000633:toxicity; D009152:Mutagenicity Tests; D009183:Mycotoxins / Q000633:toxicity*; D009285:Naphthoquinones / Q000633:toxicity*; D010860:Pigments, Biological / Q000633:toxicity*; D051381:Rats
D009183:Mycotoxins; D009285:Naphthoquinones; D010860:Pigments, Biological; C039399:floccosin; C009688:xanthomegnin; C039500:luteosporin; C039501:aurosporin; D004121:Dimethyl Sulfoxide