[Ultrastructural expression of the process of cell fusion in a rat neurinoma culture exposed to polyethylene glycol].
The time course of cell fusion was examined in experiments made with a new cell line derived from rat neurinoma. Exposure to polyethylene glycol (PEG) combined with dimethylsulfoxide led to absorption of cells on plasmalemmas, modification of glycocalyx, disorganization of plasmalemmas in local zones of adjacent membranes, and formation of the common zones of the cytoplasm between neighboring cells. The method used promoted the obtaining of polykaryons, which was accompanied by a decrease in PEG cytotoxicity.
D000818:Animals; D002459:Cell Fusion / Q000187:drug effects*; D002460:Cell Line; D008854:Microscopy, Electron; D009442:Neurilemmoma / Q000648:ultrastructure*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D051381:Rats
D011092:Polyethylene Glycols
Ul'trastrukturnoe vyrazhenie protsessa sliianiia kletok kul'tury nevrinomy krysy pri deĭstvii poliétilenglikolia.