Impaired protein synthesis in leukemic hairy cells induced by splenectomy.
A case of hairy-cell leukemia in which protein synthesis by the leukemic hairy cells could be followed-up before and after splenectomy is presented. After splenectomy a remarkable reduction of initially enhanced protein synthesis was found. This observation supports the view that the splenic microenvironment has an important influence on the proliferative activity of hairy cells.
D005260:Female; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000378:metabolism* / Q000601:surgery; D008875:Middle Aged; D008928:Mitochondria / Q000378:metabolism; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D013156:Splenectomy
D009363:Neoplasm Proteins