Evidence for the occurrence of O-glycosidically linked oligosaccharides of poly-N-acetyllactosamine type on the human leucocyte common antigen.
High molecular weight glycoproteins of human B and T lymphocytes known as leucocyte common antigen or T200 have been shown to carry O- and N-glycosidically linked, sialylated, carbohydrate chains. The O-linked chains are polydisperse and those of B rather than T cell type are highly susceptible to degradation by endo-beta-galactosidase. These differences among lymphocytes that are functionally distinct raise the possibility that the oligosaccharides may contribute to the functions of these differentiation molecules as well as to their electrophoretic diversity.
D000941:Antigens / Q000302:isolation & purification*; D001402:B-Lymphocytes / Q000276:immunology*; D055598:Chemical Phenomena; D002621:Chemistry; D002850:Chromatography, Gel; D006023:Glycoproteins / Q000302:isolation & purification*; D006801:Humans; D008970:Molecular Weight; D009844:Oligosaccharides / Q000302:isolation & purification*; D011134:Polysaccharides / Q000302:isolation & purification*; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D006023:Glycoproteins; D009844:Oligosaccharides; D011134:Polysaccharides; C037199:poly-N-acetyllactosamine