title: Bacterial modulation of the cellular immune response in mice. II. Stimulation by endotoxin of the reduced cellular immune response to LCM virus infection in aged mice.
abstract: Aging mice treated with radio-detoxified endotoxin and subsequently inoculated intracerebrally with lymphocytic choriomeningitis (LCM) virus died earlier and in a higher rate than the virus infected and otherwise untreated controls. Thus, in mice with insufficient T lymphocyte function due to aging, the radio-detoxified endotoxin pretreatment contributed to the outcome of LCM virus infection in the form of lethal meningitis. That indicates a stimulatory effect on the reduced cellular immunological reaction to the virus infection.
mesh_terms: D000367:Age Factors; D000818:Animals; D000833:Animals, Suckling; D004731:Endotoxins / Q000276:immunology / Q000528:radiation effects*; D005260:Female; D007111:Immunity, Cellular; D008216:Lymphocytic Choriomeningitis / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size; D010567:Pertussis Vaccine / Q000276:immunology / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000033:anatomy & histology / Q000502:physiology
chemical_list: D004731:Endotoxins; D010567:Pertussis Vaccine; C010797:tolerin