Sodium transport across isolated epithelial structures in vitro--Ledakrin in the liposomes as a moderator of the bioelectric activity of frog skin.
The effect of Ledakrin (an acridine derivative with antineoplastic action), free or liposome-bound, on the bioelectric activity of frog skin was studied by the method of Ussing and it was shown that this activity (being a function of sodium transport) depended on the chemical composition of the liposomes as well as on the calcium content of the experimental medium. Two conclusions have been drawn: 1) the first phase of the response triggered by Ledakrin is due to its action on the cell membrane, 2) the second phase depends on an intracellular mechanism due, probably, to Ledakrin effect on the cytoskeleton.
D000200:Action Potentials / Q000187:drug effects; D000609:Aminoacridines / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002462:Cell Membrane / Q000502:physiology; D046508:Culture Techniques; D004848:Epithelium / Q000648:ultrastructure; D008081:Liposomes / Q000008:administration & dosage / Q000494:pharmacology; D009564:Nitracrine / Q000008:administration & dosage / Q000494:pharmacology*; D014677:Pharmaceutical Vehicles; D011896:Rana temporaria; D012867:Skin / Q000648:ultrastructure*; D012964:Sodium / Q000378:metabolism*
D000609:Aminoacridines; D008081:Liposomes; D014677:Pharmaceutical Vehicles; D009564:Nitracrine; D012964:Sodium