The human T-cell leukemia/lymphoma virus, lymphoma, lytic bone lesions, and hypercalcemia.
The human T-cell lymphoma (HTL) virus is a type C RNA tumor virus isolated from patients with malignancies of mature T cells. We report three patients with peripheral T-cell lymphoma, hypercalcemia, and antibodies to HTL virus. One patient presented with idiopathic hypercalcemia of 6 months' duration, two with striking lytic bone lesions, and two with circulating malignant lymphocytes. Malignant cells from all patients had surface markers characteristic of thymic-derived lymphocytes (T cells), and all patients had natural serum antibodies to disrupted HTL virus and to one or both viral structural proteins p19 and p24. Patients with adult peripheral T-cell lymphomas, particularly those that present with hypercalcemia and lytic bone lesions, may have antibodies to the type C RNA human tumor virus, HTL virus.
D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis*; D001862:Bone Resorption / Q000150:complications*; D001842:Bone and Bones / Q000473:pathology; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000150:complications*; D008198:Lymph Nodes / Q000473:pathology; D008223:Lymphoma / Q000150:complications / Q000276:immunology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010014:Osteolysis / Q000150:complications* / Q000473:pathology; D012190:Retroviridae / Q000276:immunology*; D013601:T-Lymphocytes
D000914:Antibodies, Viral