Plasma cortisol and catecholamine responses to intracerebroventricular administration of CRF to rhesus monkeys.
Synthetic ovine corticotropin releasing factor (CRF) was administered directly into the 4th ventricle of rhesus monkeys. A dose dependent increase in plasma cortisol was observed following 10 micrograms/kg, 20 micrograms/kg, and 60 micrograms/kg of CRF. Increases in plasma epinephrine were also evident following the highest dose of CRF. Plasma norepinephrine, mean arterial pressure, and heart rate did not increase significantly following CRF administration. These data suggest that in the rhesus monkey, central administration of ovine CRF leads to activation of the pituitary-adrenocortical axis at doses that do not raise plasma catecholamines.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003346:Corticotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000097:blood*; D006339:Heart Rate / Q000187:drug effects; D006854:Hydrocortisone / Q000097:blood*; D007276:Injections, Intraventricular; D008253:Macaca mulatta; D008297:Male; D009638:Norepinephrine / Q000097:blood*
D003346:Corticotropin-Releasing Hormone; D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine