In vivo differentiation of cytotoxic T lymphocytes. 1. Serum factor in immunized athymic (nu/nu) mice could differentiate CTL precursor.
Mature cytotoxic T lymphocytes (CTLs) were hardly detected by 51Cr-release assay in the spleen of C3H/He mice after an intravenous injection of spleen cells of C57BL/6 (B6) mice. B6-specific CTL generation was augmented by transfer of sera obtained from C3H/He mice inoculated subcutaneously with EL-4 cells of B6 origin, P815 cells of DBA/2 origin or MH134 cells of C3H/HeN origin or these injected intraperitoneally with sheep or chicken erythrocytes. Such a factor can be produced also by athymic (nu/nu) mice. Such an augmentation of cytotoxicity was detected also in the regional lymph nodes after subcutaneous injection of allogeneic spleen cells. This factor may be different from augmenting factors reported already.
D000818:Animals; D000941:Antigens / Q000276:immunology; D002454:Cell Differentiation; D003602:Cytotoxicity, Immunologic; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007116:Immunization, Passive; D007942:Leukemia, Experimental / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D008819:Mice, Nude; D012756:Sheep; D013602:T-Lymphocytes, Cytotoxic / Q000166:cytology* / Q000276:immunology
D000941:Antigens