Role of selenium in protection against lead intoxication.
The administration of selenium concomitantly with lead in rats restrained the lead induced enzymuria, proteinuria, enhanced urinary excretion of delta-aminolevulinic acid, inhibition of the activities of certain renal enzymes, blood delta-aminolevulinic acid dehydratase and blood, liver and kidney uptake of lead. The protective effect of selenium against lead toxicity may be attributed to a competition between selenium and lead for binding with the functional bioligands or to the in vivo formation of lead selenide.
D000818:Animals; D001667:Binding, Competitive; D007668:Kidney / Q000378:metabolism; D007854:Lead / Q000378:metabolism; D007855:Lead Poisoning / Q000517:prevention & control*; D008024:Ligands; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D012643:Selenium / Q000378:metabolism / Q000494:pharmacology*
D008024:Ligands; D007854:Lead; D012643:Selenium