BAL increases the arsenic-74 content of rabbit brain.
The 74As content of the brain of rabbits was doubled following administration of BAL (2,3-dimercapto-1-propanol). DMPS (2,3-dimercapto-1-propanesulfonic acid, sodium salt), however, decreased the rabbit brain arsenic concentration. The use of BAL as the drug of choice for treatment of arsenic intoxication should be viewed with caution and re-examined.
D000818:Animals; D001151:Arsenic / Q000378:metabolism*; D001923:Brain Chemistry / Q000187:drug effects*; D004112:Dimercaprol / Q000494:pharmacology*; D008297:Male; D011817:Rabbits; D011868:Radioisotopes
D011868:Radioisotopes; D004112:Dimercaprol; D001151:Arsenic