Enhancement of viral hepatitis B antibody (Anti-HBs) response to a synthetic cyclic peptide by priming with anti-idiotype antibodies.
In vivo injections of anti-idiotype antibodies were used to prime the immune system of mice to hepatitis B surface antigen (HBsAg). Anti-idiotype reagents in conjunction with a cyclic synthetic peptide analogous to positions 122-137 of HBsAg induced an antibody response to HBsAg (anti-HBs) comparable to that obtained with a single injection of intact HBsAg particles. In addition, high anti-HBs titers were produced in mice injected with HBsAg following anti-idiotype priming. These data indicate that anti-idiotype antibodies may be useful in priming the immune system of a host to a potential infectious agent.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000096:biosynthesis*; D006514:Hepatitis B Surface Antigens / Q000276:immunology*; D007114:Immunization; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007700:Kinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D010455:Peptides / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D007130:Immunoglobulin Idiotypes; D010455:Peptides