Prostaglandins cause an increase in serum acute-phase proteins in man, which is diminished in systemic sclerosis.
The prostaglandin E1 increases the plasma concentration of acute-phase proteins in man and decreases the concentration of certain carrier proteins. This response is greatly diminished in patients with systemic sclerosis, a chronic inflammatory disease leading to fibrosis. These findings pose new questions about the mediation of the acute-phase response and its role in controlling the inflammatory process.
D000527:Alprostadil; D001798:Blood Proteins / Q000032:analysis*; D002097:C-Reactive Protein / Q000032:analysis; D002570:Ceruloplasmin / Q000032:analysis; D002918:Chymotrypsin / Q000037:antagonists & inhibitors / Q000097:blood; D006242:Haptoglobins / Q000032:analysis; D006801:Humans; D009961:Orosomucoid / Q000032:analysis; D011228:Prealbumin / Q000032:analysis; D011458:Prostaglandins E / Q000494:pharmacology*; D012177:Retinol-Binding Proteins / Q000032:analysis; D054839:Retinol-Binding Proteins, Plasma; D012595:Scleroderma, Systemic / Q000097:blood*; D000685:Serum Amyloid A Protein / Q000032:analysis; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin / Q000032:analysis
D001798:Blood Proteins; D006242:Haptoglobins; D009961:Orosomucoid; D011228:Prealbumin; D011458:Prostaglandins E; D012177:Retinol-Binding Proteins; D054839:Retinol-Binding Proteins, Plasma; D000685:Serum Amyloid A Protein; D000514:alpha 1-Antichymotrypsin; D000515:alpha 1-Antitrypsin; D002097:C-Reactive Protein; D002570:Ceruloplasmin; D002918:Chymotrypsin; D000527:Alprostadil