title: Interleukin 2 (IL2) is assigned to human chromosome 4.
abstract: The human gene for interleukin 2 (IL2) was assigned to chromosome 4 using human-mouse somatic cell hybrids and Southern filter hybridization of cell hybrid DNA. To identify IL2, a recombinant DNA probe ( pIL2 - 50A ) was used which contained a human interleukin 2 cDNA insert which hybridized to a 3.5-kb fragment in human DNA when cleaved with the restriction enzyme EcoRI.
mesh_terms: D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D002874:Chromosome Mapping; D002905:Chromosomes, Human, 4-5; D004247:DNA / Q000378:metabolism; D006801:Humans; D006822:Hybrid Cells / Q000502:physiology; D007376:Interleukin-2 / Q000235:genetics*; D051379:Mice; D009693:Nucleic Acid Hybridization; D010957:Plasmids
chemical_list: D007376:Interleukin-2; D004247:DNA