[Effect of sodium thiosulfate on viable areas of the pancreas in experimental pancreatitis].
Experimental pancreatitis in white rats is marked by stromal edema, dystrophic changes of acinar cells, with intracellular edema in an intact part of the pancreas. Subsequently the acinar cells undergo intracellular regeneration and hypertrophy, which is accompanied by intensive incorporation of 14C-leucin into glandular proteins. Sodium thiosulfate prevents the development of stromal edema and intracellular edema of the acinar cells and retards the development of acinar cell hypertrophy. The drug produces an inhibitory action on 14C-leucin incorporation into pancreatic proteins.
D000818:Animals; D000931:Antidotes; D007930:Leucine / Q000378:metabolism; D010179:Pancreas / Q000187:drug effects / Q000473:pathology; D010195:Pancreatitis / Q000188:drug therapy* / Q000473:pathology; D011506:Proteins / Q000378:metabolism; D051381:Rats; D013885:Thiosulfates / Q000627:therapeutic use*
D000931:Antidotes; D011506:Proteins; D013885:Thiosulfates; D007930:Leucine; C017717:sodium thiosulfate
Vliianie tiosul'fata natriia na zhiznesposobnye otdely podzheludochnoĭ zhelezy pri éksperimental'nom pankreatite.