title: Gingival hyperplasia caused by nifedipine--a preliminary report.
abstract: We observed marked gingival hyperplasia, similar clinically and histologically to the hyperplasia caused by 5:5 sodium diphenylhydantoin (Dilantin) during the last 18 months in five patients treated by nifedipine. Histologically, marked epithelial hyperplasia-acanthosis, with moderate inflammatory reaction in the lamina propria, was observed in all the biopsy specimens. Evidence points to a strong relationship between the gingival hyperplasia and the administration of nifedipine.
mesh_terms: D000368:Aged; D001026:Coronary Artery Bypass; D005260:Female; D005881:Gingiva / Q000473:pathology; D005885:Gingival Hyperplasia / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy / Q000601:surgery; D009543:Nifedipine / Q000009:adverse effects*; D011183:Postoperative Complications / Q000188:drug therapy; D012214:Rheumatic Heart Disease / Q000188:drug therapy
chemical_list: D009543:Nifedipine