[Donor immunization with an inactivated concentrated purified vaccine against tick-borne encephalitis to obtain immune blood preparations].
Vaccination of seronegative and seropositive donors with a concentrated purified vaccine (CV) against tick-borne encephalitis induced antibody synthesis in a concentration sufficient for preparation of donor immunoglobulin with antibody titres of 1:320 to 1:1280 by HI test. The resulting preparation showed a high antiviral activity both in vivo and in vitro against antigenically different strains of tick-borne encephalitis virus. The immune plasma derived from CV-immunized donors had a therapeutic effect in patients with tick-borne encephalitis. The optimal schedules for immunization of donors are discussed.
D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D000914:Antibodies, Viral / Q000032:analysis; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology*; D004675:Encephalitis, Tick-Borne / Q000628:therapy; D006801:Humans; D007114:Immunization; D007115:Immunization Schedule; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000302:isolation & purification*; D008875:Middle Aged; D010949:Plasma / Q000276:immunology*; D010956:Plasmapheresis; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000302:isolation & purification; D014765:Viral Vaccines / Q000008:administration & dosage* / Q000302:isolation & purification
D000888:Antibodies, Anti-Idiotypic; D000914:Antibodies, Viral; D007136:Immunoglobulins; D014613:Vaccines, Attenuated; D014765:Viral Vaccines
Immunizatsiia donorov inaktivirovannoĭ kontsentratrirovannoĭ ochishchennoĭ vaktsinoĭ protiv kleshchevogo éntsefalita dlia polucheniia immunnykh preparatov krovi.