New alpha-amylase inhibitor, trestatins. IV. Taxonomy of the producing strains and fermentation of trestatin A.
Taxonomic characteristics of strains NR-320-OM7HB and NR-320-OM7HBS producing a homologous series of new alpha-amylase inhibitors named trestatins are described, together with the comparison of these strains with similar Streptomyces species by DNA-DNA hybridization. A new species, Streptomyces dimorphogenes sp. nov. Watanabe and Maruyama is proposed as a result of the studies. The type strain of this species is strain NR-320-OM7HB (ATCC 31484), and the morphovar is strain NR-320-OM7HBS (ATCC 31485). The productivity of trestatin A, major and most active component, using these two strains in flask culture is also presented.
D005285:Fermentation; D009844:Oligosaccharides / Q000096:biosynthesis*; D013302:Streptomyces / Q000145:classification* / Q000254:growth & development / Q000378:metabolism; D014312:Trisaccharides / Q000096:biosynthesis*; D000516:alpha-Amylases / Q000037:antagonists & inhibitors*
D009844:Oligosaccharides; D014312:Trisaccharides; C038505:trestatin; D000516:alpha-Amylases