Influence of oxalate on the rate of the tricarboxylic acid cycle in rat hepatocytes.
In hepatocytes isolated from fed rats, physiological concentrations of oxalate lower the flux through the tricarboxylic acid cycle (-48%) and reduce the steady-state levels of oxaloacetate and other Krebs cycle intermediates. All the metabolic modifications observed are explained by pyruvate carboxylase inhibition, since oxalate hardly modifies the flux through pyruvate dehydrogenase.
D000818:Animals; D002952:Citric Acid Cycle / Q000187:drug effects*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010070:Oxalates / Q000494:pharmacology*; D019815:Oxalic Acid; D011766:Pyruvate Carboxylase / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains
D010070:Oxalates; D019815:Oxalic Acid; D011766:Pyruvate Carboxylase