Acrokeratoelastoidosis.
Acrokeratoelastoidosis is a very rare entity of unknown etiology, characterized by small, firm, yellowish, translucent papules which usually appear on the margins of the hands and feet between the junction of the dorsal and palmar/plantar skin. Histologically, the most characteristic features are hyperkeratosis, mild acanthosis, and, most strikingly, fragmentation of coarse elastic fibers within the reticular dermis. This eruption is variable in terms of its onset, may be sporadic or familial, is generally asymptomatic, and has a prolonged course.
D000051:Acantholysis / Q000473:pathology; D001706:Biopsy; D004547:Elastic Tissue / Q000473:pathology; D005260:Female; D006801:Humans; D007642:Keratosis / Q000473:pathology; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology*