title: [Neurotrophic control of the mechanism of action potential generation in frog muscle fibers].
abstract: Muscle denervation or blockade of axoplasmic transport with colchicine exert no effect on the AP rate of rise, or phase of repolarization, amplitude of overshoot, critical revel of depolarization, or their sensitivity to tetrodotoxin in frog skeletal muscle fibers. But under these conditions the difference in the rate of AP rise in sensitive and insensitive to acetylcholine zones of muscle's membrane disappears, APa become resistant against ouabain, and 36% of examined fibers display rhythmic spike activity after a single depolarizing  stimulum. Adrenaline increases and high Ca2+ concentration or disruption of muscle fiber's sarcoplasmic tubules in opposite side decrease the number of fibers with the rhythmic spike activity. The activity seems to be due to changes in regenerative ion permeability and ion pump of skeletal muscle fiber membrane which are under the neurotrophic control. The substances transported to the muscle with axoplasmic flow take part in this mechanism.
mesh_terms: D000200:Action Potentials; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D003078:Colchicine / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D009046:Motor Neurons / Q000502:physiology*; D009121:Muscle Denervation; D009132:Muscles / Q000502:physiology*; D009566:Nitrates / Q000494:pharmacology; D010042:Ouabain / Q000494:pharmacology; D011895:Rana ridibunda
chemical_list: D009566:Nitrates; D010042:Ouabain; C031618:sodium nitrate; D003078:Colchicine; D002118:Calcium; D004837:Epinephrine
vernacular_title: Neĭrotroficheskiĭ kontrol' mekhanizma generatsii potentsiala deĭstviia v myshechnykh voloknakh liagushki.