Primary amino acid sequence similarity between human epidermal growth factor-urogastrone, human pancreatic secretory trypsin inhibitor, and members of porcine secretin family.
Sequence similarities are detected between human epidermal growth factor-urogastrone, human pancreatic secretory trypsin inhibitor, and members of the secretin family of gastrointestinal hormones, particularly gastric inhibitory peptide. These similarities suggest a common evolutionary origin for these proteins and a possible functional relationship, as evidenced by the ability of human epidermal growth factor-urogastrone and human pancreatic secretory trypsin inhibitor to form a complex with protease and the ability of human epidermal growth factor-urogastrone and secretin family members to inhibit gastric acid secretion.
D000595:Amino Acid Sequence; D000818:Animals; D004815:Epidermal Growth Factor; D006801:Humans; D010179:Pancreas; D012633:Secretin; D013552:Swine; D014359:Trypsin Inhibitor, Kazal Pancreatic; D014361:Trypsin Inhibitors
D014361:Trypsin Inhibitors; D012633:Secretin; D014359:Trypsin Inhibitor, Kazal Pancreatic; D004815:Epidermal Growth Factor