B cell numbers and responses in patients with common variable immunodeficiency and nodular lymphoid hyperplasia of the bowel.
Nodular lymphoid hyperplasia ( NLH ) of the intestine is a lymphoid proliferation which occurs in patients with common variable immunodeficiency disorders ( CVID ). The nodules contain B cells but their pathogenesis is unknown. To determine whether the presence or absence of NLH might be associated with blood B cell abnormalities we studied CVID patients with and without NLH . CVID patients with NLH had a higher percentage of B cells in their blood than those without NLH . Blood lymphocytes from both groups of CVID patients proliferated less well in Cowan Staph. A stimulated cultures than control lymphocytes. Similar trends were observed in cultures stimulated with pokeweed mitogen and analyzed by karyotype. Our results suggest that blood B cells from patients with NLH are relatively unresponsive to B cell mitogens despite their near-normal numbers.
D000293:Adolescent; D000328:Adult; D000361:Agammaglobulinemia / Q000097:blood / Q000276:immunology* / Q000473:pathology; D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology* / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007421:Intestine, Small; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000473:pathology*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D011043:Pokeweed Mitogens / Q000494:pharmacology; D012007:Rectum; D013205:Staphylococcal Protein A / Q000494:pharmacology
D011043:Pokeweed Mitogens; D013205:Staphylococcal Protein A