Improved method to measure erythrocyte filtration times increased extremely by chlorate.
A method is presented that allows the measurement of erythrocyte filtration times that are extremely prolonged. Filtration times through polycarbonate sieves are increased by a factor of 40 after 2 h incubation with 30 mM sodium chlorate. This increase in red cell rigidity offers an explanation for the haemolysis observed in chlorate poisoning in vivo.
D002704:Chlorates; D004912:Erythrocytes; D006801:Humans; D013997:Time Factors; D014462:Ultrafiltration / Q000295:instrumentation / Q000379:methods
D002704:Chlorates; C032706:sodium chlorate