Macrophage activation with ubiquinones and their related compounds in mice.
The effect of ubiquinones (Q-2, -7 and -10) and their related compounds (QSA-1, -4, -6, -10 and -18) on macrophage functions was investigated. All compounds tested in this study, except QSA-4 and -6, augmented macrophage-mediated functions such as cytolysis, cytostasis and H2O2 release. Furthermore, QSA-10 and QSA-10(H2) were also shown to increase antibody-dependent cell-mediated cytotoxicity. However, QSA-10(Phenol), which lacks a quinone ring, was not observed these activities. It was suggested that quinone ring might be important for the expression of macrophage activation.
D000818:Animals; D003470:Culture Media; D005260:Female; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007700:Kinetics; D008262:Macrophage Activation / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D010587:Phagocytosis / Q000187:drug effects; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000494:pharmacology
D003470:Culture Media; D014451:Ubiquinone; D006861:Hydrogen Peroxide