The regeneration of rectal epithelium in the rat following wounding with suppositories of polyoxyethylene (23) lauryl ether.
The regeneration of the epithelial compartments of the rectal mucosa in rats has been quantified at time intervals up to one week following wounding with suppositories of the surfactant polyoxyethylene-(23)-lauryl ether. Regeneration of glandular tissue was complete within one week of the wounding, with new glands arising from residual gland bases and from surface invagination of empty crypt skeletons and underlying granulation tissue. This method of wounding appears to be particularly useful for the study of epithelial regeneration since there was a minimal connective tissue response to the insult.
D000818:Animals; D004848:Epithelium / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology; D006097:Granulation Tissue / Q000473:pathology; D007413:Intestinal Mucosa / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D000077423:Polidocanol; D011092:Polyethylene Glycols; D051381:Rats; D011919:Rats, Inbred Strains; D012007:Rectum / Q000187:drug effects / Q000473:pathology / Q000503:physiopathology*; D012038:Regeneration; D013488:Suppositories; D013997:Time Factors
D013488:Suppositories; D000077423:Polidocanol; D011092:Polyethylene Glycols