Incidence of T cell subset imbalance in relatives of Graves' disease patients.
In previous reports we demonstrated imbalances of T cell subsets in patients with autoimmune thyroid disease. In the present investigation, we studied several T cell markers with different functional meaning (Fc gamma-receptors, HLA-Ia antigens, MLR4 and 5/9 antigens) in first degree relatives of Graves' disease patients. Our data suggest that imbalances of circulating T cell subpopulations are apparent only when abnormal hormone levels and/or thyroid autoantibodies are present.
D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D002648:Child; D005260:Female; D006111:Graves Disease / Q000097:blood / Q000235:genetics* / Q000276:immunology; D006801:Humans; D007141:Immunoglobulin Fc Fragments; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*; D013961:Thyroid Gland / Q000276:immunology; D013963:Thyroid Hormones / Q000097:blood
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D007141:Immunoglobulin Fc Fragments; D013963:Thyroid Hormones