Phenylbutazone-induced nephrotoxicity in the rat.
Male Wistar rats showed reduced urinary concentrating ability after 2 weeks' administration of phenylbutazone at 200 mg/kg/day. Male Sprague-Dawley rats showed progressive proteinuria and developed renal papillary necrosis when given phenylbutazone at 200 mg/kg/day for 13 weeks. It is suggested that strain differences exist in the nephrotoxic profiles of rats given high doses of phenylbutazone.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D007668:Kidney / Q000187:drug effects / Q000473:pathology*; D008297:Male; D009336:Necrosis; D009929:Organ Size / Q000187:drug effects; D010653:Phenylbutazone / Q000633:toxicity*; D011507:Proteinuria; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014556:Urine
D010653:Phenylbutazone