title: Transport characteristics of p-acetamidobenzoic acid in brush border membrane of rat small intestine.
abstract: Brush border membrane vesicles of rat small intestinal mucosa were prepared by the modified calcium precipitation method in order to investigate the intestinal secretion mechanism of p-acetamidobenzoic acid (Ac-PABA). The release rate of [14C]-Ac-PABA from preloaded vesicles was much faster than that of p-aminobenzoic acid (PABA) and was enhanced by the addition of unlabelled Ac-PABA in the outer medium. In contrast, the membrane transfer rate of Ac-PABA across the egg lecithin liposomes was slower than that of PABA. The contribution of a carrier-mediated transport mechanism in the brush border membrane to the intestinal secretion of Ac-PABA was suggested.
mesh_terms: D010129:4-Aminobenzoic Acid / Q000378:metabolism*; D062365:Aminobenzoates / Q000378:metabolism*; D000818:Animals; D001693:Biological Transport, Active; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism; D008871:Microvilli / Q000378:metabolism; D051381:Rats; D062366:para-Aminobenzoates
chemical_list: D062365:Aminobenzoates; D008081:Liposomes; D062366:para-Aminobenzoates; C023730:Acedoben; D010129:4-Aminobenzoic Acid