Cell mediated inhibition of erythropoiesis and megaloblastic anemia in T-cell chronic lymphocytic leukemia.
A patient with T-cell chronic lymphocytic leukemia presented with severe megaloblastic anemia with normal serum folic acid and cobalamin concentrations. BFU-E could not be cultured from the patient's peripheral blood unless T-lymphocytes were removed by E-rosette formation. Inhibitory activity by the patient's T-cells was restricted to autologous BFU-E. After cyclic chemotherapy the anemia and megaloblastic changes resolved, peripheral blood BFU-E could be cultured from unfractionated peripheral blood and the T-cell inhibitory activity could no longer be demonstrated. The anemia in this patient is probably due to the neoplastic expansion of a suppressor T-lymphocyte population.
D000328:Adult; D000748:Anemia, Macrocytic / Q000209:etiology*; D000749:Anemia, Megaloblastic / Q000209:etiology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D000970:Antineoplastic Agents / Q000627:therapeutic use; D003114:Colony-Forming Units Assay; D004920:Erythropoiesis; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000188:drug therapy / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes
D000911:Antibodies, Monoclonal; D000970:Antineoplastic Agents