Cytokines and the chronic inflammation of rheumatic disease. I. The presence of interleukin-1 in synovial fluids.
Synovial fluids from patients with rheumatoid arthritis (13 cases), ankylosing spondylitis (six), psoriatic arthritis (two), osteoarthritis (three) and rubella arthritis (four) contain interleukin-1 (Il-1) activity as measured in the CH3/He mouse thymocyte assay. That this activity is Il-1 was shown by: (i) the time course of thymocyte stimulation; (ii) failure of PHA blast cells to absorb out the activity; (iii) molecular weight of 15,000-20,000 daltons, and (iv) ability to stimulate prostaglandin E2 production from synovial cells. These results indicate that IL-1 is an important mediator in the inflammatory pathway of different types of joint disease.
D000818:Animals; D001168:Arthritis / Q000276:immunology*; D001172:Arthritis, Rheumatoid / Q000276:immunology; D002455:Cell Division; D002850:Chromatography, Gel; D015232:Dinoprostone; D006801:Humans; D007375:Interleukin-1 / Q000032:analysis*; D008213:Lymphocyte Activation; D051379:Mice; D008970:Molecular Weight; D010003:Osteoarthritis / Q000276:immunology; D011458:Prostaglandins E / Q000096:biosynthesis; D013167:Spondylitis, Ankylosing / Q000276:immunology; D013582:Synovial Fluid / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D007375:Interleukin-1; D011458:Prostaglandins E; D015232:Dinoprostone