title: [Fundamental and clinical studies on T-1982 (cefbuperazone) in the field of obstetrics and gynecology].
abstract: Fundamental and clinical studies were carried out on T-1982 (cefbuperazone) a new cephamycin antibiotic, with the following result. Following a single intravenous administration of 1.0 g of T-1982, the transfer of T-1982 to the internal genital organs was found to be good. The transfer of T-1982 to retroperitoneal fluid was also good. In clinical trial, T-1982 was administered to 10 patients with obstetrical and gynecological infection. Efficacy was excellent in 4 cases and good in 6 cases. No side effects were observed. In laboratory findings, a transient elevation of alkaline phosphatase was noted in 1 case.
mesh_terms: D000328:Adult; D001202:Ascitic Fluid / Q000032:analysis; D002513:Cephamycins / Q000378:metabolism* / Q000627:therapeutic use; D004716:Endometritis / Q000188:drug therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D010538:Peritonitis / Q000188:drug therapy; D011247:Pregnancy; D011645:Puerperal Infection / Q000188:drug therapy; D014599:Uterus / Q000032:analysis
chemical_list: D002513:Cephamycins; C035978:cefbuperazone