Adenovirus fiber protein produces synthesis of interferon in mouse spleen and macrophage cultures.
An inhibitor of viral activity appears in BALB/c mice spleen cells and macrophage cultures treated with adenovirus 2 fiber protein. This inhibitor was partially characterized and identified as type I interferon. Macrophage cultures produced higher titers of this interferon than did spleen cells. Thus, a purified viral protein with B-cell mitogenic activity induced synthesis of interferon in murine cells.
D000256:Adenoviridae / Q000378:metabolism*; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D007370:Interferon Type I / Q000096:biosynthesis*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008934:Mitogens / Q000494:pharmacology; D013154:Spleen / Q000276:immunology; D014764:Viral Proteins / Q000494:pharmacology*
D007370:Interferon Type I; D008934:Mitogens; D014764:Viral Proteins