[Value of the piribedil test in diagnosing migraine. Apropos of 150 cases].
Patients with migraine show a hypersensitivity to dopamine or its agonists. One of these, piribedil, was administered as 0,1 mg/kg intravenously over 30 minutes to 150 subjects with either migraine or other types of headache. This test provoked nausea and vomiting in 94 p. cent of patients with migraine, and a rapid fall in blood pressure requiring immediate interruption of the infusion in 69 p. cent. In contrast, in those subjects with chronic non-migrainous headache the administration of piribedil had no effect in 61 p. cent and provoked a fall in blood pressure in only 16 p. cent. The piribedil test appears to possess good specificity vis-à-vis migraine, enabling a differential diagnosis from atypical periodic headache, a condition difficult to consider as migrain or psychogenic headache on clinical grounds alone.
D000328:Adult; D001794:Blood Pressure; D003937:Diagnosis, Differential; D005260:Female; D006261:Headache / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000145:classification / Q000503:physiopathology*; D009325:Nausea / Q000139:chemically induced; D010879:Piperazines; D010891:Piribedil; D014839:Vomiting / Q000139:chemically induced
D010879:Piperazines; D010891:Piribedil
Intérêt du test au piribédil dans le diagnostic de la migraine. A propos de cent cinquante cas.