[Radiation treatment with metronidazole in patients with oral mucosa cancer in the late stages].
Eighty patients with cancer of the oral mucosa at late stages were treated by a split course of gamma-beam therapy in two variants of dose fractionation as an independent therapeutic method. Metronidazole (at a summary dose of 30 g/m2) was given to 40 patients 3-4 h before irradiation. Short-term results of a 6-month-follow up have shown that radiation therapy with metronidazole improves the results. Six months after termination of gamma-beam therapy 30 patients have been alive, after radiation therapy with metronidazole 38 patients.
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005260:Female; D005720:Gamma Rays / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy*; D009367:Neoplasm Staging; D011832:Radiation Injuries / Q000453:epidemiology; D011879:Radiotherapy Dosage; D013997:Time Factors; D014062:Tongue Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy
D008795:Metronidazole
Luchevoe lechenie s primeneniem metronidazola bol'nykh rakom slizistoĭ obolochki polosti rta v pozdnikh stadiiakh.