title: Alpha 2 high molecular mass cysteine proteinase inhibitor: HMr alpha 2-CPI. An inhibitor of human liver cathepsin H as probed by kinetic study.
abstract: HMr alpha 2CPI was found to be an inhibitor of human liver cathepsin H by the measurement of the dissociation constant (Ki), the association rate constant (k1) and the dissociation rate constant (k-1) between the enzyme and the inhibitor. These data suggest that this protein-proteinase inhibitor can play a physiological role in the regulation of free cathepsin H.
mesh_terms: D002403:Cathepsins / Q000037:antagonists & inhibitors*; D015853:Cysteine Proteinase Inhibitors; D006801:Humans; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D008247:Lysosomes / Q000201:enzymology; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*
chemical_list: D015853:Cysteine Proteinase Inhibitors; D011506:Proteins; D002403:Cathepsins