Effect of Feloran (diclofenac sodium) on the oxidative phosphorylation of rat liver mitochondria.
The effect of Feloran (diclofenac sodium) on rat liver mitochondria is studied. It is shown that in concentrations of the order of 0.1 mM Feloran blocks the second or third point of the respiratory chain, inhibits the soluble mitochondrial ATPase and uncouples oxidative phosphorylation. In addition, there is also an increase in the ionic permeability of the inner mitochondrial membrane. These effects are assumed to be important for the anti-inflammatory action of Feloran.
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D004008:Diclofenac / Q000494:pharmacology*; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010648:Phenylacetates / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D010648:Phenylacetates; D004008:Diclofenac