Effects of probucol on homozygous cases of familial hypercholesterolemia.
A marked reduction of serum cholesterol was obtained by treatment with probucol in heterozygous as well as in homozygous cases of familial hypercholesterolemia. A strict dietary regimen (low-fat, low-calories) intensified the hypocholesterolemic effect of the drug. The drug was also useful in diminishing the rebound of serum cholesterol after plasma exchange. Probucol reduced serum triglycerides in heterozygous cases of familial hypercholesterolemia, but there was a slight increase in triglycerides in homozygous cases. Treatment with probucol resulted in the regression of cutaneous and tendon xanthomas. Although it caused a decrease in HDL, it seems to be very effective in the treatment of familial hypercholesterolemia.
D000293:Adolescent; D000328:Adult; D000924:Anticholesteremic Agents / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D002149:Energy Intake; D005260:Female; D006720:Homozygote; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000188:drug therapy* / Q000628:therapy; D008148:Lovastatin / Q000031:analogs & derivatives*; D008297:Male; D008875:Middle Aged; D009281:Naphthalenes / Q000627:therapeutic use; D010636:Phenols / Q000627:therapeutic use*; D010951:Plasma Exchange; D011341:Probucol / Q000627:therapeutic use*; D012871:Skin Diseases / Q000188:drug therapy; D013710:Tendons; D014280:Triglycerides / Q000097:blood; D014973:Xanthomatosis / Q000188:drug therapy
D000924:Anticholesteremic Agents; D009281:Naphthalenes; D010636:Phenols; D014280:Triglycerides; C012258:mevastatin; D002784:Cholesterol; D008148:Lovastatin; D011341:Probucol