[Mechanism of action of reserpine on the blood circulation and oxygen regimen of the brain].
Resistography was used in experiments on anesthetized cats to show that reserpine produced biphasic (dilatation and constrictor) reactions on the part of the cerebral, extracranial and peripheral vessels. The dilatation reaction occurred immediately after the drug administration, it was intermittent and preserved after the blockade of the adreno- and cholinoreceptors. During electric stimulation of the cervical sympathetic ganglia, reserpine insignificantly reduced constrictor reactions of the vessels and inhibited depressor reactions. After intravenous injection of rausedyl the cerebral blood flow and oxygen consumption by the brain tissue decreased.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000502:physiology; D002415:Cats; D002536:Cerebral Arteries / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004558:Electric Stimulation; D005728:Ganglia, Sympathetic / Q000502:physiology; D010101:Oxygen Consumption / Q000187:drug effects*; D012110:Reserpine / Q000494:pharmacology*; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
D012110:Reserpine
K mekhanizmu deĭstviia rezerpina na krovoobrashchenie i kislorodnyĭ rezhim golovnogo mozga.