Effect of phenytoin and carbamazepine on subpopulations of mononuclear blood cells as defined by membrane antigens.
Mononuclear cells from peripheral blood of healthy blood donors were incubated with phenytoin 20 micrograms/ml or carbamazepine 10 micrograms/ml for 30 min at 37 degrees C. In 4 out of 10 incubation experiments, the percentage of cells expressing the membrane antigen T3 was markedly reduced. However, the mean percentage of cells expressing the antigens T3, T4, T8 and HLA-DR was not influenced significantly by incubation with the drugs. Accordingly, the reduction of IgA and IgM serum concentrations in patients on phenytoin and carbamazepine is most probably not due to changes in T regulator lymphocytes.
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis*; D002220:Carbamazepine / Q000494:pharmacology*; D006801:Humans; D009000:Monocytes / Q000145:classification* / Q000276:immunology; D010672:Phenytoin / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000145:classification
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D002220:Carbamazepine; D010672:Phenytoin