Oscillating repolarization in action potentials of frog sensory myelinated nerve fibres.
Current and voltage clamp experiments were performed in single myelinated sensory nerve fibres of Rana esculenta. The K current was blocked by external tetraethylammonium-chloride and internal CsCl. Negative prepotentials led to the formation of a plateau in the repolarization phase of the action potential, and further regenerative depolarizations emerged from this plateau. A three-state model for Na inactivation based on voltage clamp data was sufficient to simulate these observations.
D000200:Action Potentials; D000818:Animals; D002463:Cell Membrane Permeability; D066298:In Vitro Techniques; D008959:Models, Neurological; D009413:Nerve Fibers, Myelinated / Q000502:physiology; D009431:Neural Conduction; D009475:Neurons, Afferent / Q000502:physiology*; D011188:Potassium / Q000502:physiology; D011893:Rana esculenta; D012964:Sodium / Q000502:physiology
D012964:Sodium; D011188:Potassium