Alteration in membrane permeability by diacylglycerol and phosphatidylcholine containing arachidonic acid.
The phospholipid metabolites, stearoylarachidonylglycerol and diarachidonylglycerol, stimulate transepithelial sodium transport in frog skin epithelium. The increase in Na transport is due to an increase in the unidirectional influx of sodium, is amiloride sensitive and is prevented with pretreatment with indomethacin, mefanamic acid and phospholipase inhibitor, mepacrine. The data suggest a possible role of phospholipid metabolism and prostaglandin biosynthesis in the regulation of transepithelial ion transport.
D000584:Amiloride / Q000494:pharmacology; D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects; D004075:Diglycerides / Q000494:pharmacology*; D004848:Epithelium / Q000187:drug effects / Q000502:physiology; D005989:Glycerides / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D010713:Phosphatidylcholines / Q000494:pharmacology*; D011894:Rana pipiens; D012867:Skin / Q000187:drug effects; D012879:Skin Physiological Phenomena; D012964:Sodium / Q000378:metabolism*; D013329:Structure-Activity Relationship
D001095:Arachidonic Acids; D004075:Diglycerides; D005989:Glycerides; D010713:Phosphatidylcholines; C037149:stearoylarachidonylglycerol; D000584:Amiloride; C035561:diarachidonyl diglyceride; D012964:Sodium