[Animal experiments on the gastric mucosa and demonstration of analgesic and antipyretic effects after combined administration of acetylsalicylic acid and sodium pyruvate].
Animal experimental examinations in guinea pigs and rats demonstrate the positive influence of sodium pyruvate on lesions of the gastric mucosa induced by acetylsalicylic acid. As compared to pure acetylsalicylic acid a combination of acetylsalicylic acid and sodium pyruvate reduces significantly the numbers of erosions, ulcers and hemorrhages on the gastric mucosa. Sodium pyruvate protects effectively against the undesired side-effects by acetylsalicylic acid. The analgetic and antipyretic effect of acetylsalicylic acid is not impaired by the addition of sodium pyruvate.
D000700:Analgesics; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001241:Aspirin / Q000494:pharmacology*; D016227:Benzoquinones; D004347:Drug Interactions; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D006168:Guinea Pigs; D008297:Male; D051379:Mice; D011749:Pyrogens / Q000037:antagonists & inhibitors; D011773:Pyruvates / Q000494:pharmacology*; D019289:Pyruvic Acid; D011809:Quinones / Q000037:antagonists & inhibitors; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016227:Benzoquinones; D011749:Pyrogens; D011773:Pyruvates; D011809:Quinones; C029322:phenylbenzoquinone; D019289:Pyruvic Acid; D001241:Aspirin
Tierexperimentelle Untersuchungen der Magenschleimhaut und Nachweis des analgetischen und antipyretischen Wirkung nach kombinierter Gabe von Acetylsalicylsäure und Natriumpyruvat.