[A procedure for testing the permeation of dissolved active agents through polyethylene. 85: Contributions to problems concerning the use of plastic containers for liquid pharmaceutical preparations].
The transfer principle is used for determining the amount of substance that has permeated through polyethylene. The transfer behaviour informs about the permeation of soluted substances contained in polyethylene containers. The permeation increases as the temperature of experiment, the initial concentration of the substance solution and the wall thickness of the container increase. The permeation remains constant at the beginning and decreases with decreasing substance concentration. The permeation percentage depends but little on the initial concentration. The technique described is suitable for studying the permeation behaviour of substances with high vapour pressure.
D004349:Drug Packaging; D008610:Menthol / Q000032:analysis; D009281:Naphthalenes / Q000032:analysis; D010539:Permeability; D011095:Polyethylenes; D012996:Solutions; D013696:Temperature; D013997:Time Factors
D009281:Naphthalenes; D011095:Polyethylenes; D012996:Solutions; D008610:Menthol
Uber ein Verfahren zur Prüfung der Permeation gelöster Wirkstoffe durch Polyethylen. 85. Mitteilung: Beiträge zur Problematik des Einsatzes von Kunststoffbehältern für flüssige Arzneizubereitungen.