title: Fasciola hepatica: migration of newly excysted juveniles in resistant rats.
abstract: Using transmission and scanning electron microscopy, the early migration of juvenile Fasciola hepatica was examined in naive and resistant rats. In naive rats, the migration of flukes to the peritoneal cavity was uneventful. In resistant rats, flukes were rapidly coated with antibody whilst still in the gut lumen and a proportion of the flukes were unable to penetrate the intestinal wall. Those that did penetrate were unharmed as they crossed the gut wall, but on entering the peritoneal cavity they were coated with antibody and host cells including eosinophils, neutrophils, macrophages, and mast cells. Eosinophils were seen degranulating onto the fluke surface, and this appeared to result in the erosion of the tegumental syncytium.
mesh_terms: D000818:Animals; D000906:Antibodies; D004804:Eosinophils / Q000276:immunology; D005210:Fasciola hepatica / Q000276:immunology / Q000502:physiology* / Q000648:ultrastructure; D005211:Fascioliasis / Q000276:immunology* / Q000469:parasitology; D005260:Female; D007110:Immunity, Active; D007421:Intestine, Small / Q000469:parasitology; D008264:Macrophages / Q000276:immunology; D009068:Movement; D009504:Neutrophils / Q000276:immunology; D010529:Peritoneal Cavity / Q000469:parasitology; D051381:Rats
chemical_list: D000906:Antibodies