[Enzymes are the allergenic components of inhaled pancreatin].
Pancreatic extracts had caused respiratory disease in five patients. Four of them were not atopic. In four cases alpha-amylase and in two cases trypsin could be identified as causative allergen using RAST and RAST-inhibition. In addition, demonstration of immunologic cross-reactivity between porcine and bovine pancreatin was possible. This most likely can be attributed to the structurally closely related enzymes alpha-amylase and trypsin occurring in both animal species.
D000328:Adult; D000485:Allergens / Q000032:analysis*; D001985:Bronchial Provocation Tests; D004345:Drug Industry; D005260:Female; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced*; D010194:Pancreatin / Q000009:adverse effects / Q000276:immunology*; D011852:Radioallergosorbent Test; D012130:Respiratory Hypersensitivity / Q000139:chemically induced*; D014357:Trypsin / Q000276:immunology*; D000516:alpha-Amylases / Q000276:immunology*
D000485:Allergens; D007073:Immunoglobulin E; D010194:Pancreatin; D000516:alpha-Amylases; D014357:Trypsin
Enzyme sind die allergenwirksamen Komponenten von inhaliertem Pankreatin.