[Histopathological studies on bladder carcinoma. 2: Role of local lymph follicle and immunoblast cells].
The relationship between the cellular stromal reaction and systemic immunity was examined in 34 cases of bladder tumors. To determine the cellular stromal reaction, we examined the local lymph follicles such as peritumoral lymphocyte accumulation, and the immunoblast cells having abundant, basophilic cytoplasm with large vesicular nuclei which contained 1-3 large and irregular nucleoli. To measure systemic immunity, lymphocytes, T cells, B cells, IgG-Fc receptor T cells, and lymphocyte blast formation ratio with PHA were examined. The survival rate was higher in the group with a strong stromal reaction. The distribution of the immunoblast cells showed a tendency to accumulate in the paracortical area of the local lymph follicles. Examination of the depth of tumor infiltration and grade revealed many local lymph follicles and immunoblast cells in pT 2 and G 2 groups. The groups in which lymph follicles and/or immunoblast cells were positive showed a tendency of high lymphocyte blastformation ratio with PHA accompanied by a low percentage of IgG-Fc receptor T cells. These findings suggest that local lymph follicles and immunoblast cells may be a manifestation of the systemic immunity acting as a tumor defense mechanism.
D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D001749:Urinary Bladder Neoplasms / Q000276:immunology* / Q000473:pathology