Catharanthus alkaloids XXXVII. 16-Epi-Z-isositsirikine, a monomeric indole alkaloid with antineoplastic activity from Catharanthus roseus and Rhazya stricta.
16-Epi-Z-isositsirikine (1) has been isolated from the leaves of Catharanthus roseus and Rhazya stricta and identified through a combination of spectral interpretation and chemical correlation. The compound displayed antineoplastic activity in the KB test system in vitro and the P-388 test system in vivo.
D000107:Acetylation; D000470:Alkaloids; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D007211:Indoles / Q000302:isolation & purification* / Q000494:pharmacology; D051379:Mice; D008968:Molecular Conformation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010946:Plants, Medicinal / Q000032:analysis*
D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic; D007211:Indoles; C038932:16-epi-isositsirikine