The blood schizontocidal action of erythromycin against Plasmodium knowlesi infections in Macaca mulatta.
Chloroquine-induced pigment clumping (CIPC) in vitro in Plasmodium knowlesi is inhibited by 7.3 micrograms ml-1 erythromycin. P. knowlesi infections in rhesus monkeys were controlled by doses of erythromycin which gave similar serum levels of the antibiotic. The antimalarial effect was complete but temporary, and recrudescences were noted.
D000818:Animals; D001769:Blood / Q000469:parasitology; D002738:Chloroquine / Q000494:pharmacology; D004917:Erythromycin / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use*; D008253:Macaca mulatta; D008288:Malaria / Q000188:drug therapy* / Q000469:parasitology; D008297:Male; D010961:Plasmodium / Q000187:drug effects
C010948:erythromycin lactobionate; D004917:Erythromycin; D002738:Chloroquine; C011462:erythromycin stearate