[Mitochondrial enzymes in circulating lymphocytes during hemosorption for experimental hypercholesterolemia].
The status of some dehydrogenases (succinate dehydrogenase, mitochondrial alpha-glycerophosphate dehydrogenase and beta-hydroxybutyrate dehydrogenase) was studied in the course of long-term oral administration of cholesterol to rabbits. The data obtained indicate that within the first weeks of cholesterol administration there was a decrease in enzymatic activity of the dehydrogenases under study that mirrored the impairment of energy function of mitochondria. After experiments were initiated, alimentary hypercholesterolemia led to imbalance of anabolism and catabolism bearing resemblance to the status of oxidative processes in the Krebs cycle. There is every reason to believe that such a complex of changes in the dehydrogenases during hypercholesterolemia is characteristic for the initial stages of atherosclerosis. Elimination of cholesterol from the body by single hemosorption results in a tendency towards making the circulating lymphocytes egress from hypoxia. It is inferred that study of enzymatic activity of dehydrogenases should be used for the diagnosis of and the assessment of therapeutic measures for atherosclerosis under experimental and clinical conditions.
D000818:Animals; D005993:Glycerolphosphate Dehydrogenase / Q000097:blood; D006464:Hemoperfusion; D006884:Hydroxybutyrate Dehydrogenase / Q000097:blood; D006937:Hypercholesterolemia / Q000201:enzymology / Q000628:therapy*; D008214:Lymphocytes / Q000201:enzymology*; D008297:Male; D008928:Mitochondria / Q000201:enzymology*; D011817:Rabbits; D013385:Succinate Dehydrogenase / Q000097:blood
D005993:Glycerolphosphate Dehydrogenase; D006884:Hydroxybutyrate Dehydrogenase; D013385:Succinate Dehydrogenase
Izuchenie nekotorykh mitokhondrial'nykh fermentov v tsirkuliruiushchikh limfotsitakh pri gemosorbtsii v sviazi s éksperimental'noĭ giperkholesterinemieĭ.