Assessment of dopamine receptor densities in the human brain with carbon-11-labeled N-methylspiperone.
We describe the use of carbon-11-labeled 3-N-methylspiperone, a ligand that preferentially binds to dopamine receptors in vivo, to image the receptors by positron emission tomography scanning in baboons and, for the first time, in a human. The method has now been used in 58 humans for noninvasive assessment of the state of brain dopamine receptors under normal and pathological conditions.
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002090:Butyrophenones; D002250:Carbon Radioisotopes; D006801:Humans; D008297:Male; D008875:Middle Aged; D010215:Papio; D011954:Receptors, Dopamine / Q000032:analysis*; D013134:Spiperone / Q000031:analogs & derivatives; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
D002090:Butyrophenones; D002250:Carbon Radioisotopes; D011954:Receptors, Dopamine; D013134:Spiperone; C039167:3-N-methylspiperone