Norepinephrine and dopamine levels in hypothalamic nuclei of the genetically obese mouse (ob/ob).
An analysis of the norepinephrine (NE) and dopamine (DA) levels in specific hypothalamic nuclei of the genetically obese mouse (ob/ob) was made. When compared to lean littermate controls ob/ob mice had significantly increased levels of NE in the paraventricular nucleus and lateral hypothalamus and significantly decreased levels of DA in the arcuate-infundibulum. The sites of these neurochemical abnormalities correspond to hypothalamic areas involved in the regulation of feeding and prolactin secretion, both of which are abnormal in the ob/ob mutant.
D000818:Animals; D004298:Dopamine / Q000032:analysis*; D005247:Feeding Behavior / Q000502:physiology; D007031:Hypothalamus / Q000032:analysis* / Q000502:physiology; D051379:Mice; D008810:Mice, Inbred C57BL; D008820:Mice, Obese; D009638:Norepinephrine / Q000032:analysis*; D009765:Obesity / Q000235:genetics* / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism
D011388:Prolactin; D004298:Dopamine; D009638:Norepinephrine