Increased immunoglobulin production in vitro in healthy HLA-B8-positive persons.
The histocompatibility antigens B8 and DR3 are associated with several autoimmune diseases, and immune hyper-responsiveness has been believed to be one factor in the pathogenesis of these diseases. In the present study we compared the in vitro immunoglobulin production of healthy HLA-B8-positive individuals with that of HLA-B8-negative individuals. In HLA-B8-positive persons a higher number of pokeweed mitogen (PWM)-stimulated Ig-secreting cells was obtained. When the cells were stimulated with PWM in the presence of a physiological concentration of hydrocortisone (HC), the secretion of IgG was significantly higher in HLA-B8-positive individuals. This finding indicates that the PWM-stimulated IgG secretion in healthy HLA-B8-positive individuals is more sensitive for the enhancing action of HC.
D000921:Antibody-Producing Cells / Q000276:immunology; D001168:Arthritis / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D015795:HLA-B8 Antigen; D006801:Humans; D007070:Immunoglobulin A / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007136:Immunoglobulins / Q000096:biosynthesis*; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D011043:Pokeweed Mitogens / Q000276:immunology
D006680:HLA Antigens; D015795:HLA-B8 Antigen; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D011043:Pokeweed Mitogens