title: Surgically reversible hypothalamic hypopituitarism due to aqueductal stenosis. Case report.
abstract: A 13-year-old girl was referred for evaluation of the deceleration in her rate of linear growth, an arrest in the progression of her pubertal maturation, and bifrontal headaches. Detailed endocrinological and radiological studies revealed the following abnormalities: partial growth hormone deficiency, prepubertal luteinizing hormone and follicle-stimulating hormone responses to exogenous gonadotropin-releasing hormone, aqueductal stenosis with obstructive hydrocephalus, and marked focal dilation of her third ventricle. Ventriculoperitoneal shunting resulted in increased linear growth, resumption of pubertal development, and correction of her documented neuroendocrine abnormalities.
mesh_terms: D000293:Adolescent; D001927:Brain Diseases / Q000150:complications; D002535:Cerebral Aqueduct; D014695:Cerebral Ventriculography; D003251:Constriction, Pathologic; D005260:Female; D006065:Gonadotropins, Pituitary / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology / Q000601:surgery; D007018:Hypopituitarism / Q000209:etiology / Q000378:metabolism / Q000601:surgery*; D007027:Hypothalamic Diseases / Q000209:etiology / Q000378:metabolism / Q000601:surgery*
chemical_list: D006065:Gonadotropins, Pituitary; D013006:Growth Hormone