Spontaneous and apomorphine-induced locomotor changes parallel dopamine receptor differences in two rat strains.
Two inbred strains of rats (F344 and Buffalo) were tested for differences in spontaneous and apomorphine-induced inhibition of locomotor activity. F344 rats showed greater percentage decreases in locomotion after apomorphine (0.25, 1.0 and 2.5 mg/kg) compared to the Buffalo strain. F344 rats also showed higher levels and slower habituation of spontaneous locomotor activity. F344 rats had previously been shown to have significantly higher densities of D2-dopamine receptors in the striatum and olfactory tubercle and also more apomorphine-induced stereotypy when compared to Buffalo rats. These results confirm and extend previous studies suggesting that genetic differences in brain D2-dopamine receptors can predict behavioral differences in locomotor activity.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011915:Rats, Inbred BUF / Q000235:genetics; D011916:Rats, Inbred F344 / Q000235:genetics; D011919:Rats, Inbred Strains / Q000235:genetics*; D011954:Receptors, Dopamine / Q000235:genetics*; D013045:Species Specificity
D011954:Receptors, Dopamine; D001058:Apomorphine