title: Two types of acetylcholine receptors on the soma of primary afferent neurons.
abstract: Acetylcholine (ACh) caused two types of depolarizations of the soma membrane of bullfrog primary afferent neurons (dorsal root ganglion cells); the one, a rapid transient depolarization, was nicotinic and the other, a long-lasting one, was muscarinic in nature, respectively. The rapid transient depolarization was due to a simultaneous increase in sodium and potassium conductance, whereas the slow one was caused by a decrease in membrane potassium conductance. These results indicate that the soma of bullfrog primary afferent neuron is endowed with nicotinic and muscarinic receptors.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D005727:Ganglia, Spinal / Q000187:drug effects / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D009116:Muscarine / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009538:Nicotine / Q000494:pharmacology; D011892:Rana catesbeiana; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D014403:Tubocurarine / Q000494:pharmacology
chemical_list: D011950:Receptors, Cholinergic; D009538:Nicotine; D009116:Muscarine; D000109:Acetylcholine; D014403:Tubocurarine