Altered behaviour of erythrocytes in scleroderma.
Filterability (deformability) of erythrocytes of patients with Raynaud's phenomenon together with progressive systemic sclerosis (PSS) was decreased compared with the filtration of erythrocytes from normal subjects. PSS erythrocytes showed lower electrophoretic velocity and about 23% less neuraminidase-removable sialic acid density on their surface than the normal erythrocytes. PSS erythrocytes showed more adherence to cultured endothelial cells than the control normal erythrocytes. It is concluded that the increased rigidity and adherence of PSS erythrocytes may have pathological significance in the mechanism of vascular abnormalities in PSS.
D000328:Adult; D000368:Aged; D002448:Cell Adhesion; D004727:Endothelium / Q000166:cytology; D004912:Erythrocytes / Q000032:analysis / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D008564:Membrane Potentials; D008875:Middle Aged; D011928:Raynaud Disease / Q000097:blood; D012595:Scleroderma, Systemic / Q000097:blood*; D012794:Sialic Acids / Q000097:blood
D012794:Sialic Acids