[Effect of thrombin on the arterial blood pressure level and on cardiac activity in rats].
The influence of the thrombin intravenous injection on the level of the arterial pressure of nonanaesthetized rats has been studied. It has been found out that different doses of thrombin cause two phases vibration of pressure: rapid decrease and slower increase of arterial pressure. Hexenal anaesthesia does not change degree and speed of pressure decrease but reduces the restoration of the initial level and eliminates the increasing pressure phase. The effect grows with the thrombin dose increasing and sharply reduces under anaesthesia. The interrelation of the phenomena established and the adaptive significance for living organism is being discussed.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects*; D008297:Male; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D013917:Thrombin / Q000494:pharmacology*; D013997:Time Factors
D013917:Thrombin
Vliianie trombina na uroven' arterial'nogo krovianogo davleniia i serdechnuiu deiatel'nost' krys.