Fatty acid synthesis and ketone body utilization by brown adipose tissue of the rat. Response to cold or nutritional state?
The effects of cold adaptation (exposure to 2-4 degrees C for 2-3 weeks) on the incorporation of 3H from 3H2O and of D-3-hydroxy [3- 14C]butyrate into fatty acid in vivo in interscapular brown adipose tissue of the rat were examined. Fatty acid synthesis, measured with 3H2O, was increased in brown adipose tissue of cold-adapted rats pair-fed ad libitum but not in cold-adapted rats pair-fed to the same food intake as rats maintained at 18-20 degrees C. Incorporation of D-3-hydroxybutyrate into fatty acid was increased in brown adipose tissue of cold-adapted rats, both when rats were fed ad libitum and when they were deprived of food for 48 h. Ketone bodies may be an important substrate for brown adipose tissue in the cold-adapted rat.
D000064:Acclimatization; D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D003080:Cold Temperature; D005227:Fatty Acids / Q000096:biosynthesis*; D007413:Intestinal Mucosa / Q000378:metabolism; D007657:Ketone Bodies / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005227:Fatty Acids; D007657:Ketone Bodies