Long-term response to ovariectomy in 35 premenopausal patients with advanced breast cancer, treated in coherence with hormonal tests.
Thirty-five premenopausal patients with metastasized or locally advanced breast cancer underwent ovariectomy. At relapse, after surgery, they were treated with hormone therapy or chemotherapy, according to hormonal tests carried out before the castration. Five-year survival, computed with the actuarial method, confirmed the better prognosis of the hormone-dependent patients and also an improved prognosis in the patients treated with hormone therapy after ovariectomy. Furthermore, chemotherapy proved more efficacious: an increased survival was observed in the non-hormone-dependent patients.
D015113:Androstane-3,17-diol / Q000652:urine*; D000732:Androstanols / Q000652:urine*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D002369:Castration; D005260:Female; D006801:Humans; D011182:Postoperative Care; D011960:Receptors, Estrogen / Q000032:analysis*; D013739:Testosterone / Q000652:urine*
D000732:Androstanols; D011960:Receptors, Estrogen; D015113:Androstane-3,17-diol; D013739:Testosterone