Monensin does not prevent recycling of plasma membrane glycoconjugates.
Plasma membrane glycoconjugates, internalized during fluid-phase pinocytosis in the macrophage cell line, P388D1, were found to be rapidly recycled to the cell surface, also in the case where the cells had been treated with 25 microM monensin for 80 min which resulted in a reduction of the pinocytotic uptake rate to 30%. The result is discussed in terms of the intracellular pathway of internalized membrane.
D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism*; D005663:Furans / Q000494:pharmacology*; D005690:Galactose / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism*; D007700:Kinetics; D008264:Macrophages; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D008985:Monensin / Q000494:pharmacology*; D010873:Pinocytosis / Q000187:drug effects
D005663:Furans; D006023:Glycoproteins; D008565:Membrane Proteins; D008985:Monensin; D005690:Galactose