Responsiveness of human lung diploid fibroblast ageing in vitro to epidermal growth factor: saturation density and lifespan.
Epidermal growth factor (EGF) in culture medium increased the saturation density of human diploid fibroblasts. In the first half of their in vitro lifespan the magnitude of the EGF-induced augmentation increased and in the second half, decreased. Their lifespan was not extended by continuous exposure to EGF.
D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D006801:Humans; D008168:Lung / Q000166:cytology
D004815:Epidermal Growth Factor