L-5-hydroxytryptophan for LSD-induced psychosis.
The serotonin precursor L-5-hydroxytryptophan reversed the symptoms of a 23-year-old man suffering from LSD-induced psychosis who participated in a randomized, double-blind crossover study of the drug and a placebo. This finding is compatible with the speculation that some LSD-induced psychotic disorders may be caused by a relative deficiency of CNS serotonin.
D006916:5-Hydroxytryptophan / Q000627:therapeutic use*; D000328:Adult; D004311:Double-Blind Method; D006801:Humans; D008238:Lysergic Acid Diethylamide; D008297:Male; D011605:Psychoses, Substance-Induced / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D011897:Random Allocation; D012701:Serotonin / Q000502:physiology; D019966:Substance-Related Disorders / Q000150:complications*
D012701:Serotonin; D008238:Lysergic Acid Diethylamide; D006916:5-Hydroxytryptophan