Synthesis and some biological properties of substituted xanthone-2-carboxylic acids.
Xanthone-2-carboxylic acids 4a-4k were synthesized as potential antiphlogistic compounds, and compounds 4a-4c and 4f-4i were tested for anti-inflammatory and analgesic properties. In the carrageenin paw edema the most potent of the series acid 4b displayed the activity which was approx one third of that of ketoprofen.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis*; D002351:Carrageenan; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D066298:In Vitro Techniques; D051381:Rats; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013329:Structure-Activity Relationship; D014966:Xanthenes / Q000138:chemical synthesis* / Q000494:pharmacology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D014966:Xanthenes; D002351:Carrageenan