Cyclosporin A--a pre-recruitment action in the cutaneous response?
Mononuclear cell accumulation in rat skin sites, over a 24 h period following intradermal injections of concanavalin A (Con A) and carrageenan, was quantitated using an isotopic technique. Cyclosporin A (CS-A) inhibited the accumulation of [51Cr]-labelled blood mononuclear cells into cutaneous reactions to Con A but not carrageenan reactions in the same animals. Conversely, indomethacin or cobra venom factor inhibited cell accumulation into carrageenan-induced lesion, whilst leaving infiltration into Con A reactions unimpaired. Since CS-A did not show a general anti-inflammatory effect, it is suggested that this compound reduces cell accumulation by inhibiting the local release of lymphokines in vivo.
D000818:Animals; D002351:Carrageenan / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology; D003524:Cyclosporins / Q000494:pharmacology*; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects*; D008222:Lymphokines / Q000096:biosynthesis; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D012867:Skin / Q000187:drug effects* / Q000276:immunology
D003524:Cyclosporins; D008222:Lymphokines; D003208:Concanavalin A; D002351:Carrageenan