Staphylococcal protein-A is a potent T-cell mitogen of tonsillar lymphocytes.
Optimal conditions for the stimulation of human tonsillar lymphocytes by staphylococcal protein-A (SpA) are described. By stimulating fractions enriched or depleted of E-rosette forming cells, the response was shown to be predominantly a T-cell response. A comparison of stimulation by SpA with that of phytohaemagglutinin (PHA) proved SpA to be a potent T-cell mitogen. We suggest that SpA may be another useful mitogen for studying human T-cell growth and differentiation.
D006801:Humans; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D008934:Mitogens; D014066:Palatine Tonsil / Q000166:cytology / Q000276:immunology*; D010835:Phytohemagglutinins / Q000494:pharmacology; D013205:Staphylococcal Protein A / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology*
D008934:Mitogens; D010835:Phytohemagglutinins; D013205:Staphylococcal Protein A