Induction of immunity to a human tumor marker by in vivo administration of anti-idiotypic antibodies in mice.
Anti-idiotypic antibodies are described that were raised against murine monoclonal antibody 8.2, an antibody specific for a human melanoma-associated cell surface marker called p97. The 8.2 idiotopes recognized by this anti-idiotypic antiserum are binding site-associated and are shared by other monoclonal anti-p97 antibodies with the same specificity as antibody 8.2. Mice immunized with the anti-idiotype demonstrate delayed-type hypersensitivity reactions when challenged with melanoma (p97-positive) tumor cells.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D000912:Antibodies, Neoplasm / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007111:Immunity, Cellular; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D008545:Melanoma / Q000276:immunology*; D051379:Mice
D000888:Antibodies, Anti-Idiotypic; D000912:Antibodies, Neoplasm; D000954:Antigens, Surface; D007130:Immunoglobulin Idiotypes