Investigation into the combined hepatotoxicity of rolitetracycline and ethinyloestradiol.
The effect of rolitetracycline (50 micrograms/g i.v.) alone or in combination with ethinylestradiol (0.1 and 1.0 micrograms/g s.c. once daily for 4 days) on liver function (BSP retention, serum GPT and SDH) and histomorphology was investigated in mice. Rolitetracycline alone increased liver weight, BSP-retention and serum GPT levels. Ethinylestradiol at the lower dose tended to enhance the BSP retention and the morphological changes of the liver produced by rolitetracycline but had no additional effect on the serum GPT and on liver weight. In contrast, hepatotoxic effects of the higher dose of ethinylestradiol were not further enhanced by rolitetracycline.
D000818:Animals; D004997:Ethinyl Estradiol / Q000633:toxicity*; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D012382:Rolitetracycline / Q000633:toxicity*
D004997:Ethinyl Estradiol; D012382:Rolitetracycline