title: [Significance of high titers of various autoantibodies in the diagnosis and monitoring of chronic liver diseases].
abstract: The diagnostic value of the high antibody titres are assessed in the work--namely antinuclear, antimitochondrial and antismooth-muscular, in chronic liver diseases. For that purpose 220 patients with morphologically confirmed chronic hepatitis and chronic liver cirrhosis were examined. Twenty three of them proved to have high titre antibodies. It was established that the females predominated in that group--20 out of 23. The high titre of autoantibodies correlated with the morphological data for the activity of the liver injury. No connection was established with the presence or absence of HB-virus markers in the cases with high titres of ASMA. HB-virus markers were found in none of the eight patients with high titres AMA. One of the six patients with high titres ANA had HBs-antigenemia. In the patients with high titres of autoantibodies, hyperimmunoglobulinemia, class IgG was most often established, whereas IgA and IgM were found almost with the same incidence in normal and elevated values. There were enzymologic data about hepatocytolysis and cholestasis in the majority of the cases. ASMA titre decreased in parallel with the decrease of the activity of the morbid process under the treatment effect.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000974:Antibodies, Antinuclear / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis*; D002908:Chronic Disease; D005260:Female; D006505:Hepatitis / Q000175:diagnosis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D008103:Liver Cirrhosis / Q000175:diagnosis; D008105:Liver Cirrhosis, Biliary / Q000175:diagnosis; D008107:Liver Diseases / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000276:immunology; D009130:Muscle, Smooth / Q000276:immunology
chemical_list: D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D006514:Hepatitis B Surface Antigens
vernacular_title: Znachenie na visokite titri na niakoi avtoantitela za diagnostikata i proslediavaneto na khronichnite chernodrobni zaboliavaniia.