title: Lipogenic capacity and relative contribution of the different tissues and organs to lipid synthesis in male rat.
abstract: The rates of 3H2O incorporation into total lipids and fatty acids were measured in vivo in the different organs and tissues of 7-week old male Wistar rats to compare the lipogenic capacity of those organs and tissues and to determine their relative contributions to body lipid synthesis. Our results were the following; (1) liver was the major site of the synthesis of total lipids and fatty acids (37 and 42%, respectively, of body synthesis); (2) white adipose tissues synthesized about 24% of the total lipids; mesenteric adipose tissue alone synthesizing 40% of the fatty acids produced in dissectable white adipose tissues; (3) skin showed low lipid synthesis but played an appreciable role in that synthesis (8% of the total) due to its large contribution to total body weight; (4) other organs (excluding liver) showed low lipid synthesis; however, that of the small intestine was 1-2% of body synthesis; (5) the rest of the carcass (mainly musculature and skeleton) contributed 25% to body lipid synthesis. The putative roles of the different tissues and organs in adipose tissue development have been discussed.
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D005227:Fatty Acids / Q000096:biosynthesis; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D005227:Fatty Acids; D008055:Lipids