Logistic models for prediction of enteric morbidity in the treatment of ovarian and cervical cancers.
To identify patients at high risk for the development of enteric injury, an analysis was made of 212 women who received extensive pelvic and abdominal radiotherapy at the University of Minnesota from 1970 through 1981. One hundred one patients with cervical carcinomas received 8,000 to 8,500 rads to point A, 6,000 rads to point B, and 4,500 to 5,075 rads to the periaortic lymph nodes. One hundred eleven women with ovarian cancers received 2,000 rads to the entire abdomen, followed by an additional 2,975 to 3,000 rads to the pelvis. The overall complication rate was 6.6% (14/212). The only patients who sustained chronic radiation morbidity had thin physiques. The maximum likelihood multiple logistic model was utilized to predict the probability of enteric injury as a function of thin physique, previous operations, and hypertension for individual patients. The usefulness of predictive models is discussed, and possible reasons for the susceptibility of thin women to ionizing radiation are explored.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D006973:Hypertension / Q000150:complications; D007410:Intestinal Diseases / Q000175:diagnosis* / Q000209:etiology; D008875:Middle Aged; D008954:Models, Biological; D009748:Nutrition Disorders / Q000175:diagnosis; D010051:Ovarian Neoplasms / Q000150:complications / Q000532:radiotherapy*; D011379:Prognosis; D011832:Radiation Injuries / Q000175:diagnosis*; D011879:Radiotherapy Dosage; D013008:Somatotypes; D002583:Uterine Cervical Neoplasms / Q000150:complications / Q000532:radiotherapy*