[Antiradiation and toxic effect of ATP, AET and serotonin administered in combination to mice. Optimal relations between component doses].
It was established that the optimal dose ratio (high effectiveness and minimum toxicity) between the components in the combination: serotonin/AET/ATP was 1/3/45. It was shown that the radioprotective effect was conditioned by AET and serotonin the latter being more significant. ATP played a minor role in the total protective effect decreasing however, the toxicity of the combination.
D000255:Adenosine Triphosphate / Q000008:administration & dosage*; D000818:Animals; D004359:Drug Therapy, Combination; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D012701:Serotonin / Q000008:administration & dosage*; D000338:beta-Aminoethyl Isothiourea / Q000008:administration & dosage*
D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; D012701:Serotonin; D000255:Adenosine Triphosphate
Protivoluchevoĭ i toksicheskiĭ éffekt ATF, AET i serotonina pri kombinirovannom vvedenii mysham. Optimal'nye sootnosheniia mezhdu dozami komponentov.