A case of immunodeficiency with decreased serum IgA levels and impaired polyclonal B cell differentiation in vitro.
We report a patient with low serum IgA levels and persistent pulmonary infection. In spite of the normal contents of serum IgG and IgM, the patient had a deficiency for plasma cell differentiation of all major classes of immunoglobulins (IgG, IgA and IgM). Cross culture systems between normal T or B cells and the patient's T or B cells showed a defect of both T and B cell function.
D000293:Adolescent; D001402:B-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D004406:Dysgammaglobulinemia / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis; D008213:Lymphocyte Activation; D008297:Male; D011014:Pneumonia / Q000276:immunology*; D011043:Pokeweed Mitogens / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology
D007070:Immunoglobulin A; D007075:Immunoglobulin M; D011043:Pokeweed Mitogens