Topical protection against long-wave ultraviolet A.
A PABA ester-oxybenzone preparation is superior to PABA or sulisobenzone alone in protecting the skin from methoxsalen-induced ultraviolet A (UVA) phototoxicity after water substantivity challenge. Such a mixture would be useful as a UVA screen for uninvolved or actinically damaged skin in patients receiving psoralens and ultraviolet A (PUVA) therapy. An effective topical UVA screen also may protect against UVA-induced diseases like solar urticaria, polymorphic light eruptions, drug-induced phototoxicity or photoallergy, and possibly against the deep degenerative changes of solar elastosis.
D010129:4-Aminobenzoic Acid / Q000008:administration & dosage; D000328:Adult; D001577:Benzophenones / Q000008:administration & dosage; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D008297:Male; D011701:PUVA Therapy / Q000009:adverse effects*; D010778:Photochemotherapy / Q000009:adverse effects*; D013471:Sunburn / Q000517:prevention & control; D013473:Sunscreening Agents / Q000008:administration & dosage*; D014466:Ultraviolet Rays / Q000009:adverse effects*; D062366:para-Aminobenzoates
D001577:Benzophenones; C039239:N,N-dimethyl-2-ethylhexyl-4-aminobenzoate; D013473:Sunscreening Agents; D062366:para-Aminobenzoates; C009361:sulisobenzone; C005290:oxybenzone; D010129:4-Aminobenzoic Acid