The distribution of the haeme and non-haeme fractions of iron in individual regions of the erythropoietic system of intact and acutely irradiated mice.
In male mice of the strain C57BL/10ScSnPh, both intact and X-irradiated with a whole-body sublethal dose, the distribution of the content of total and haeme iron was studied in individual bones, the spleen, liver, plasma and erythrocytes, using an original mineralization and extraction technique. In the erythropoietic organs as a whole and in the individual bones the haeme and non-haeme iron compartments were distinguished, and within these the iron accounted for by circulating plasma and by erythrocytes and erythrocyte precursors. In the radiation-depleted marrow there were quantitative and qualitative changes in the compartments, particularly the creation of an important compartment of non-circulating (fixed) erythrocytes.
D000818:Animals; D001775:Blood Circulation; D001853:Bone Marrow / Q000032:analysis; D001842:Bone and Bones / Q000032:analysis; D004912:Erythrocytes / Q000032:analysis / Q000502:physiology; D004920:Erythropoiesis / Q000528:radiation effects*; D006418:Heme / Q000032:analysis* / Q000502:physiology / Q000528:radiation effects; D007501:Iron / Q000097:blood* / Q000502:physiology / Q000528:radiation effects; D008099:Liver / Q000032:analysis; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000032:analysis
D006418:Heme; D007501:Iron