title: Tpre, a new alloantigen encoded in the IgT-C region of chromosome 12, is expressed on bone marrow of nude mice, fetal T cell hybrids, and fetal thymus.
abstract: A new T cell alloantigen, Tpre, has been identified by monoclonal F.6.9.1 antibody. This antigen is encoded by a gene linked to the cluster of T cell antigens in the IgT-C region of chromosome 12 (Tthy, Tind, and Tsu). Tpre is distinct from Tthy, Tind, or Tsu because it is expressed on bone marrow cells of the AKR nustr/nustr, the thymus repopulating precursor cell in normal adult marrow, and normal fetal thymocytes. Several fetal and adult T cell hybrids express these antigens independently. Tpre and Tthy are expressed on largely overlapping cell populations in adult thymus.
mesh_terms: D000375:Aging; D000818:Animals; D000950:Antigens, Ly / Q000235:genetics*; D001853:Bone Marrow / Q000276:immunology*; D003348:Cortisone / Q000494:pharmacology; D005260:Female; D005815:Genetic Code; D006825:Hybridomas / Q000276:immunology*; D007519:Isoantigens / Q000235:genetics*; D008198:Lymph Nodes / Q000166:cytology / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D011247:Pregnancy; D014176:Protein Biosynthesis; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013950:Thymus Gland / Q000196:embryology / Q000276:immunology*
chemical_list: D000950:Antigens, Ly; D007519:Isoantigens; C037236:Tpre; D003348:Cortisone