title: [Beta-adrenergic stimulation with prenalterol in sick sinus syndrome].
abstract: The effect of beta-adrenergic receptor stimulation on sinus node function in patients with sick-sinus syndrome was investigated. Electrophysiological studies were performed in 14 patients (5 males and 9 females) aged 18-81 years before and after intravenous administration of 50 micrograms Prenalterol per kilogram body wt. Prenalterol decreased spontaneous cycle length by 26% (p less than 0.01), which corresponded to an increase in heart rate of 21 beats/min. The corrected sinus node recovery time was shortened by 23% (n.s.) in 10 patients, and was abnormal in 12 patients before and in 10 patients after Prenalterol. Secondary pauses occurred in 8 patients at control and in 9 patients after drug administration, in 2 of them for the first time after Prenalterol. In the sick-sinus syndrome the pronounced chronotropic response to beta-adrenergic receptor stimulation with Prenalterol doses not indicate improvement of impaired sinus node function.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002316:Cardiotonic Agents / Q000627:therapeutic use*; D004562:Electrocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011217:Practolol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011294:Prenalterol; D012804:Sick Sinus Syndrome / Q000188:drug therapy*; D012848:Sinoatrial Block / Q000188:drug therapy; D012849:Sinoatrial Node / Q000187:drug effects
chemical_list: D002316:Cardiotonic Agents; D011294:Prenalterol; D011217:Practolol
vernacular_title: Beta-adrenerge Stimulation mit Prenalterol beim Syndrom des kranken Sinusknotens.