[Effect of biologically active compounds of divalent platinum on the properties of the liquid crystal "microphase" of DNA].
The optical properties of the "microphases" modeling the state of the DNA molecule in the cell and formed of both the low molecular DNA and the DNA complexes with cis- and trans-isomers of dichlorodiamine platininum (II) were studied. It was shown that the intensive band characteristic of the circular dichroism spectrum of the initial DNA "microphase" was decreasing with binding of DNA to cis-Pt (II) or trans-Pt (II). The effect of cis-Pt (II) on the "microphase" optical properties was more significant than that of trans-Pt (II). The effect correlated with the biological activity of the cis- and trans-compounds of platinum. Possible causes of the decrease in the optical activity of the DNA "microphase" are discussed.
D000818:Animals; D002942:Circular Dichroism; D003460:Crystallization; D004247:DNA / Q000302:isolation & purification / Q000494:pharmacology*; D004347:Drug Interactions; D005399:Fishes; D008297:Male; D008956:Models, Chemical; D010984:Platinum / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000494:pharmacology; D012996:Solutions; D013329:Structure-Activity Relationship
D012996:Solutions; D011092:Polyethylene Glycols; D010984:Platinum; D004247:DNA
Vliianie nekotorykh biologicheski aktivnykh soedineniĭ dvukhvalentnoĭ platiny na svoĭstva zhidkokristallicheskoĭ "mikrofazy" DNK.