The effect of beta-lactamase stability, penetration, and target affinity on the activity of cefazolin, cefamandole, cefoxitin, and cefuroxime.
Four beta-lactam antibiotics, cefazolin, cefamandole, cefoxitin, and cefuroxime, were tested for their ability to penetrate the bacterial cell wall, to inhibit target proteins, and to resist degradation by beta-lactamase enzymes. Cefuroxime was the only tested antibiotic that performed well in all three categories.
D001419:Bacteria / Q000187:drug effects* / Q000201:enzymology; D002435:Cefamandole / Q000494:pharmacology*; D002437:Cefazolin / Q000494:pharmacology*; D002440:Cefoxitin / Q000494:pharmacology*; D002444:Cefuroxime / Q000494:pharmacology*; D002462:Cell Membrane / Q000201:enzymology; D002463:Cell Membrane Permeability / Q000187:drug effects; D002511:Cephalosporins / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006801:Humans; D001618:beta-Lactamases / Q000378:metabolism*
D002511:Cephalosporins; D002435:Cefamandole; D002440:Cefoxitin; D001618:beta-Lactamases; D002437:Cefazolin; D002444:Cefuroxime