title: [Lung edema after administration of hydrochlorothiazide. A rare and life-threatening side effect].
abstract: Recurrent pulmonary oedema occurred in a 62-year-old woman after repeated intake of hydrochlorothiazide-triamterene tablets. Eight similar reports in the medical literature suggested it to be a rare case of intolerance to hydrochlorothiazide. The lymphocyte transformation test proved an allergic genesis: there was significant stimulation of patient lymphocytes by active agent/metabolite serum of hydrochlorothiazide but not triamterene.
mesh_terms: D004342:Drug Hypersensitivity / Q000276:immunology; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects* / Q000276:immunology; D008213:Lymphocyte Activation; D008875:Middle Aged; D011654:Pulmonary Edema / Q000139:chemically induced* / Q000188:drug therapy; D014223:Triamterene / Q000276:immunology
chemical_list: D006852:Hydrochlorothiazide; D005665:Furosemide; D014223:Triamterene
vernacular_title: Lungenödem nach Einnahme von Hydrochlorothiazid. Eine seltene, vital bedrohliche Nebenwirkung.