Erythroid colony forming cells in systemic lupus erythematosus.
The incidence of erythroid progenitor cells in the bone marrow was studied in 9 patients with systemic lupus erythematosis (SLE) in the absence of corticosteroid or immunosuppressive therapy. The incidence of late erythropoietic precursors (CFU-E) was diminished in SLE. The colony formation of marrow CFU-E was inhibited by the addition of allogeneic and autologous T lymphocytes from SLE patients before the prescription of corticosteroid. These results suggest that the T cell mediated suppression of erythroid progenitor cells may play an important role in a pathogenesis of erythropoietic failure in SLE.
D000328:Adult; D000740:Anemia / Q000209:etiology / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D002452:Cell Count; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D004920:Erythropoiesis; D005260:Female; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology