title: Effect of surgery on the in vitro response of canine peripheral blood lymphocytes to phytohemagglutinin.
abstract: The effects of surgery (ovario-hysterectomy) and anesthesia on phytohemagglutinin-induced lymphocyte blastogenesis were studied in vitro in 12 dogs. Four dogs had depressed lymphocyte blastogenic responses after surgery. This suppression was transient with normal blastogenic responses occurring in cells from all dogs 24 hours after surgery. Seemingly, T-lymphocyte function may be depressed, only transiently, after surgery.
mesh_terms: D000758:Anesthesia / Q000662:veterinary; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002369:Castration / Q000662:veterinary*; D004285:Dogs / Q000276:immunology / Q000601:surgery*; D005260:Female; D007044:Hysterectomy / Q000662:veterinary*; D007111:Immunity, Cellular / Q000187:drug effects; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins / Q000494:pharmacology*; D011184:Postoperative Period; D013601:T-Lymphocytes / Q000187:drug effects / Q000502:physiology
chemical_list: D010835:Phytohemagglutinins