[Effect of water-soluble antioxidants on the permeability of lysosomal membranes and on the structure of the liver in rats with thermal burns].
Experiments on rats were made to study the effect of water-soluble antioxidants on the permeability of lysosomal membranes of liver cells and liver structure under burn. Antioxidants were injected intraperitoneally shortly after burn, whereas examination was performed after one day. It has been discovered that one day after burn there takes place an appreciable destabilization of lysosomal membranes with the release of a lysosomal matrix enzyme, cathepsin D to the cytoplasm. Liver structure had undergone substantial changes by that time. After administration of water-soluble antioxidants lysosomal membranes got stabilized while liver structure manifested but insignificant disorders.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002056:Burns / Q000188:drug therapy* / Q000473:pathology; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use; D002463:Cell Membrane Permeability / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008247:Lysosomes / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats
D000975:Antioxidants; D002084:Butylated Hydroxytoluene
Vliianie vodorastvorimykh antioksidantov na pronitsaemost' lizosomal'nykh membran i na strukturu pecheni krys pri termicheskom ozhoge.