title: Electrical behavior of the heart following high-potassium cardioplegia.
abstract: The electrical activity of the heart was studied in 25 patients undergoing elective coronary artery bypass grafting. Simultaneous surface electrocardiograms and bipolar atrial electrograms were monitored continuously from the onset of cardioplegic arrest until normal sinus rhythm was reestablished. Several observations were made. (1) Administration of cardioplegia promptly induced and maintained ventricular arrest in all patients. (2) Atrial activity was seen in 23 patients during global ischemia. (3) Following unclamping, the first sustained rhythm was atrial in 22 patients and was associated initially with high-grade atrioventricular block progressing to 1:1 conduction after a mean reperfusion time of 23 minutes. (4) The time required for complete electrical recovery varied directly with the cross-clamp time and the amount of cardioplegic solution used. (5) Only 3 patients required ventricular defibrillation. (6) In the postoperative period, supraventricular tachyarrhythmias developed in 6 patients. Their occurrence appeared to be related to prolonged atrial activity during the cross-clamp period. Although cardioplegia administration maintained ventricular arrest, sustained atrial activity often was present, perhaps implying inadequate atrial protection and predisposing to atrial arrhythmias. Normal sinus rhythm was reestablished spontaneously in all patients. The atrial electrogram proved essential in the precise intraoperative recognition of cardiac rhythm.
mesh_terms: D000328:Adult; D000368:Aged; D016275:Atrial Function; D001026:Coronary Artery Bypass; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007552:Isotonic Solutions / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000494:pharmacology*; D017680:Potassium Compounds
chemical_list: D007552:Isotonic Solutions; D017680:Potassium Compounds; C018369:potassium cardioplegic solution; D011188:Potassium