Synergism of iron and hexachlorobenzene inhibits hepatic uroporphyrinogen decarboxylase in inbred mice.
The combination of a single subcutaneous dose of iron (12.5 mg/mouse) and subsequent treatment with hexachlorobenzene (0.02% of the diet) caused a progressive inhibition of hepatic uroporphyrinogen decarboxylase in male C57BL/10 mice leading to the accumulation of uroporphyrin in 4-6 weeks. There was only a slight inhibition of the enzyme in the absence of iron and none without hexachlorobenzene. Females were less sensitive than males. In addition, comparisons between the C57BL/10, BALB/c, AKR and DBA/2 strains indicated that the susceptibilities of mice to induction of porphyria did not completely correlate with their classification as Ah-responsive or Ah-non-responsive.
D000818:Animals; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D002722:Chlorobenzenes / Q000494:pharmacology*; D004357:Drug Synergism; D006581:Hexachlorobenzene / Q000494:pharmacology*; D007501:Iron / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D011166:Porphyrins / Q000378:metabolism; D012737:Sex Factors; D014575:Uroporphyrinogen Decarboxylase / Q000037:antagonists & inhibitors*
D002722:Chlorobenzenes; D011166:Porphyrins; D006581:Hexachlorobenzene; D007501:Iron; D002262:Carboxy-Lyases; D014575:Uroporphyrinogen Decarboxylase