Elevation of lipid peroxide in children treated with a combination of chemotherapeutic agents including doxorubicin.
The fluorometric method of Yagi was used to determine serum lipid peroxide levels in children with various types of malignancies, treated with or without doxorubicin. It was found that patients on regimens of intermittent combination chemotherapies including doxorubicin had higher levels of serum lipid peroxide and were all apparently free from cardiotoxicity. Doxorubicin was the only determinant in affecting the serum lipid peroxide value. Coenzyme Q10 given concurrently failed to reduce the elevated levels to normal.
D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003067:Coenzymes; D004317:Doxorubicin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005470:Fluorometry; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood*; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000494:pharmacology
D000970:Antineoplastic Agents; D003067:Coenzymes; D008054:Lipid Peroxides; D014451:Ubiquinone; D004317:Doxorubicin; C024989:coenzyme Q10