In vitro metabolism of aflatoxin Q1 by rat liver post-mitochondrial homogenates.
An investigation of the in vitro biotransformation of aflatoxin Q1 by the post-mitochondrial fraction of rat liver is reported. These studies showed a 10 to 25 percent turnover of aflatoxin Q1, with the subsequent formation of five metabolites. A major metabolite was determined to be the beta-D-glucuronide of aflatoxin Q1.
D000348:Aflatoxins / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D005965:Glucuronates / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver; D051381:Rats; D011919:Rats, Inbred Strains; D013347:Subcellular Fractions / Q000378:metabolism
D000348:Aflatoxins; D005965:Glucuronates; C033759:aflatoxin Q1