Platelet-associated IgM levels in thrombocytopenia.
Platelet-associated IgG (PAIgG) and IgM (PAIgM) levels were quantitated in patients with thrombocytopenias of various etiologies. 32 of 34 patients with immune thrombocytopenia had elevated PAIgG, 8 of the 34 patients had elevated PAIgM levels. Only 1 patient suffering from immune thrombocytopenia had elevated PAIgM with normal PAIgG levels. Elevated PAIgM was most often associated with elevated PAIgG except for the following: 2 patients with lymphoproliferative disorders, 1 patient with heparin-induced thrombocytopenia, 1 patient with pernicious anemia, and 2 patients with Waldenström's macroglobulinemia. PAIgM determinations may prove to be a useful adjunct for evaluating patients with thrombocytopenia, particularly those in whom the PAIgG is not elevated.
D001792:Blood Platelets / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis*; D007945:Leukemia, Lymphoid / Q000097:blood / Q000150:complications / Q000276:immunology; D008107:Liver Diseases / Q000097:blood / Q000150:complications / Q000276:immunology; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications / Q000276:immunology; D008223:Lymphoma / Q000097:blood / Q000150:complications / Q000276:immunology; D010976:Platelet Count; D013921:Thrombocytopenia / Q000097:blood / Q000276:immunology*
D007074:Immunoglobulin G; D007075:Immunoglobulin M