title: The influence of age on the effectiveness of DTPA in reducing 141Ce retention in rats.
abstract: The influence of age on the effectiveness of chelation treatment in reducing retention of radioactive cerium was studied in two- and six-week-old albino rats. 141Ce was administered intraperitoneally, followed immediately and after 24 and 48 hours by intraperitoneal administration of the tri-sodium calcium salt of diethylenetriaminepentaacetic acid--Na3(CaDTPA) at 380 mumol/kg body weight. The whole-body retention was determined 2, 4 and 6 days after radiocerium administration, when the animals were killed and the organ retention was determined. The chelation therapy significantly reduced the whole-body retention of radiocerium. This treatment was however twice as effective in older as in younger animals.
mesh_terms: D000375:Aging / Q000187:drug effects / Q000528:radiation effects*; D000818:Animals; D002565:Cerium Radioisotopes / Q000008:administration & dosage / Q000378:metabolism*; D004353:Drug Evaluation, Preclinical; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D004369:Pentetic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D011833:Radiation Injuries, Experimental / Q000188:drug therapy / Q000378:metabolism; D051381:Rats; D013997:Time Factors
chemical_list: D002565:Cerium Radioisotopes; D004369:Pentetic Acid