Common ALL with pre-B-cell features showing (8;14) and (14;18) chromosome translocations.
A 21-yr-old man presented with inguinal lymphadenopathy and splenomegaly. The peripheral blood showed a high blast cell count. The morphological and immunologic features of the blast cells were consistent with the diagnosis of common acute lymphoblastic leukemia (ALL) with 15% pre-B-cells. Banded karyotype analysis of the blood and the marrow cells, using the technique of methotrexate synchronization, revealed the presence of (8;14) and (14;18) chromosome translocations, a finding that has not been previously documented. The significance of these findings is discussed.
D000328:Adult; D001402:B-Lymphocytes; D002901:Chromosomes, Human, 13-15; D002902:Chromosomes, Human, 16-18; D002905:Chromosomes, Human, 4-5; D006801:Humans; D007945:Leukemia, Lymphoid / Q000235:genetics*; D008297:Male; D014411:Neoplastic Stem Cells; D014178:Translocation, Genetic