Gynecomastia in epileptics treated with phenobarbital, phenytoin and fluoresone: two case reports.
Gynecomastia developed in two epileptic patients some months after the addition of oral fluoresone 750 mg daily to the phenobarbital and phenytoin already being administered. The common systemic diseases that may give rise to gynecomastia were excluded. One of the patients presented hyperprolactinemia and a raised estrogen/androgen ratio but the hormone levels were not raised in the other. The onset of symptoms after fluorescence in both cases is highly suggestive, although the pathogenetic mechanism is not clear.
D000328:Adult; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy*; D006177:Gynecomastia / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects*; D010672:Phenytoin / Q000009:adverse effects*; D011388:Prolactin / Q000097:blood; D013450:Sulfones / Q000009:adverse effects*
D013450:Sulfones; C038907:fluoresone; D010672:Phenytoin; D011388:Prolactin; D010634:Phenobarbital