The effect of cimetidine on tolbutamide kinetics.
Although possible on theoretical grounds, no interaction between cimetidine and tolbutamide could be demonstrated in ten healthy volunteers. The plasma tolbutamide concentrations over 12 h following 0.5 g orally were essentially the same before and after 1 and 7 days cimetidine (400 mg twice daily).
D000328:Adult; D002927:Cimetidine / Q000097:blood / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D014044:Tolbutamide / Q000378:metabolism*
D002927:Cimetidine; D014044:Tolbutamide