[Effect of antioxidants on the release of 3H-serotonin by rat brain synaptosomes].
The effects of free radical scavengers of different chemical structure (hydroxypyridines, hindered phenols, hydroxyphenothiazines) on processes of 3H-hydroxytryptamine uptake and release by rat brain synaptosomes were studied. All free radical scavengers used inhibited 3T-hydroxytryptamine uptake and stimulated 3H-hydroxytryptamine release, with the efficacy being reduced in the following order: 7-hydroxyaminazine greater than butylated hydroxytoluene greater than paginol-2-methyl-6-ethyl-3-hydroxypyridine greater than alpha-tocopherol. The effects of free radical scavengers were eliminated in the presence of EGTA or after cooling to 4 degrees C.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002540:Cerebral Cortex / Q000378:metabolism*; D002746:Chlorpromazine / Q000031:analogs & derivatives / Q000494:pharmacology; D066298:In Vitro Techniques; D010847:Picolines / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013574:Synaptosomes / Q000378:metabolism*; D014316:Tritium; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D010847:Picolines; D014316:Tritium; D014810:Vitamin E; D002084:Butylated Hydroxytoluene; D012701:Serotonin; C007994:7-hydroxychlorpromazine; D002746:Chlorpromazine; C039550:2-methyl-6-ethyl-3-hydroxypyridine
Deĭstvie antioksidantov na vybros 3H-serotonina sinaptosomami mozga krys.