title: Evidence for hyperglycemic osmotic matrix effects on the Comprehensive Hematology Survey 1981-1982.
abstract: Several authors have suggested that a plausible mechanism for variation in reported mean corpuscular volume (MCV) and hematocrit values for Hematology Survey Specimens may be due to the presence of hyperglycemia in the suspending matrix of the specimens, resulting in cell swelling due to an osmotic matrix effect. The Hematology Resource Committee of the College of American Pathologists has examined this question prospectively and concludes, although there is evidence for an osmotic matrix effect, such an effect is insufficient to explain all the variation in MCV seen between different specimens analyzed. An instrument dependent analytic variation is present in addition to an osmotic matrix effect and appears intrinsic to the instrument systems studied. The probability that such an effect can be eliminated in preparation of an external proficiency testing program specimen is small.
mesh_terms: D001386:Azides / Q000494:pharmacology; D004909:Erythrocyte Indices / Q000187:drug effects*; D006801:Humans; D006943:Hyperglycemia / Q000097:blood* / Q000139:chemically induced; D009995:Osmosis / Q000187:drug effects; D010338:Pathology, Clinical / Q000295:instrumentation / Q000592:standards*; D011188:Potassium / Q000097:blood; D011786:Quality Control; D012955:Societies, Medical; D012964:Sodium / Q000097:blood; D014481:United States
chemical_list: D001386:Azides; C010596:Isoton; D012964:Sodium; D011188:Potassium