[Molecular mechanisms of radiation death of lymphoid cells. Chromatin degradation and DNA replication in fractions of irradiated thymocytes].
Chromatin of irradiated large and small thymocytes starts degrading 2 h following irradiation. However the yield of polydeoxynucleotides is more intensive in small thymocytes which are more radiosensitive. Immediately after irradiation small thymocytes exhibit activation of impulse incorporation of 3H-thymidine into a DNA fraction which does not exceed half the replicon by its molecular mass.
D000818:Animals; D002843:Chromatin / Q000378:metabolism / Q000528:radiation effects*; D004247:DNA / Q000096:biosynthesis; D004261:DNA Replication / Q000528:radiation effects*; D051379:Mice; D011089:Polydeoxyribonucleotides / Q000096:biosynthesis; D011836:Radiation Tolerance; D013601:T-Lymphocytes / Q000378:metabolism / Q000528:radiation effects*; D013936:Thymidine / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism / Q000528:radiation effects
D002843:Chromatin; D011089:Polydeoxyribonucleotides; D004247:DNA; D013936:Thymidine
Issledovanie molekuliarnykh mekhanizmov radiatsionnoĭ gibeli limfoidnykh kletok. Degradatsiia khromatina i replikatsiia DNK vo fraktsiiakh obluchennykh timotssitov.