In vitro effects of vasoactive intestinal polypeptide on guinea pig urinary bladder.
Vasoactive intestinal polypeptide (VIP) may have a neuronal function regulating smooth muscle activity. At concentrations ranging from 0.25 to 3.0 micrograms/ml VIP elicited no significant changes in baseline tension, magnitude, or frequency of contractions of guinea pig bladder muscle strips. Likewise, VIP did not inhibit significantly the rise in baseline tension elicited by acetylcholine or electrical stimulation.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004558:Electric Stimulation; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D013268:Stimulation, Chemical; D001743:Urinary Bladder / Q000187:drug effects*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D014660:Vasoactive Intestinal Peptide; D000109:Acetylcholine