Formation of pentachlorothioanisole from N-acetyl-S-(pentachlorophenyl) cysteine in blood and liver of rats "in vivo".
Studies on the biotransformation of N-acetyl-S-(pentachlorophenyl) cysteine, a mutual polar metabolite of the lipophilic fungicides pentachloronitrobenzene and hexachlorobenzene, showed metabolic conversions in rats. The rate of its metabolism, leading in return to more lipophilic and toxic products (1) was investigated by determination of pentachlorothioanisole, its major metabolite in blood and liver of rats. The metabolic rate was found to be very small.
D000111:Acetylcysteine / Q000031:analogs & derivatives* / Q000378:metabolism; D000818:Animals; D001711:Biotransformation; D002722:Chlorobenzenes / Q000096:biosynthesis*; D005260:Female; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012727:Sex Characteristics; D013997:Time Factors
D002722:Chlorobenzenes; C027672:pentachlorophenylmercapturic acid; C031281:pentachloromethylthiobenzene; D000111:Acetylcysteine