title: Baroreflex effects of althesin infusions to supplement nitrous oxide anaesthesia in man.
abstract: The effects on baroreflex control of heart rate, of two infusion rates of Althesin (18 and 36 micrograms kg-1 min-1 as total steroid) to supplement 66% nitrous oxide in oxygen anaesthesia, have been studied in six younger (mean age 35.5 yr) and six older (mean age 61.0 yr) patients. Steady-state anaesthesia at both infusion rates was associated with diminished baroreflex sensitivity and resetting of the reflex to allow lower arterial pressures to be maintained without tachycardia.
mesh_terms: D000328:Adult; D000530:Alfaxalone Alfadolone Mixture / Q000008:administration & dosage / Q000494:pharmacology*; D000768:Anesthesia, General; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide; D011674:Pulse / Q000187:drug effects; D012018:Reflex / Q000187:drug effects*
chemical_list: D000530:Alfaxalone Alfadolone Mixture; D009609:Nitrous Oxide