title: [Pharmacologic profile of a new compound with antiinflammatory activity: 2-(4-dimethylvinylphenyl)propionic acid (Gx 258)].
abstract: Gx 258, a new phenylalkanoic acid derivative, was shown in animal tests to possess potent antiinflammatory, analgesic and antipyretic activity. Its antiinflammatory activity was not mediated via the pituitary-adrenal axis, since it was also effective in adrenalectomized rats. Since large doses of Gx 258, 9-83 times greater than those showing antiinflammatory activity, were required to produce gastrointestinal lesions in rats, Gx 258 appears to have a very good therapeutic index. Its therapeutic index as an antiinflammatory and analgesic agent was 2.3-20.5 times greater than that of the parent compound ibuprofen. Gx 258, like ibuprofen, inhibited the biosynthesis of prostaglandins in vitro.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000633:toxicity; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001169:Arthritis, Experimental / Q000188:drug therapy; D002417:Cattle; D004064:Digestive System / Q000187:drug effects; D004487:Edema / Q000188:drug therapy; D005260:Female; D007052:Ibuprofen / Q000031:analogs & derivatives* / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D011453:Prostaglandins; C042011:2-(4-dimethylvinylphenyl)propionic acid; D007052:Ibuprofen
vernacular_title: Profilo farmacologico di un nuovo composto ad attività antiinfiammatoria: l'acido 2-(4-dimetilvinilfenil)propionico (Gx 258).