Effect of a putative antidepressant, Rolipram, on the circadian running wheel activity of a day-active chipmunk, Eutamias sibiricus.
Siberian chipmunks (Eutamias sibiricus) were kept individually in small cages attached to a running wheel. Under continuous illumination of two different light intensities (0.4-0.9 lux and 400-1200 lux) the influence of Rolipram, a putative new antidepressant, on the period length tau was tested. Under both conditions Rolipram caused a lengthening of tau, a decrease of activity time alpha and an increase of rest time delta, resulting in a decrease of the alpha/delta ratio. These effects of Rolipram could be due to a slowing down of the circadian oscillatory system or an influence on the sensitivity towards light.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D002940:Circadian Rhythm / Q000187:drug effects*; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D011760:Pyrrolidinones / Q000494:pharmacology*; D020889:Rolipram; D012589:Sciuridae
D000928:Antidepressive Agents; D011760:Pyrrolidinones; D020889:Rolipram