[Effects of isometheptene on gallbladder contraction].
In order to verify the influence of the adrenergic system on the gallbladder contraction the Authors studied the effect of isometeptene, a sympathomimetic drug active on beta receptors, on gallbladder emptying. The gallbladder was studied on 6 subjects using a real-time (linear array) equipment with a 3,5 MHz transducer. In fasting subjects the gallbladder emptying was obtained by a fatty meal. In the next day the fatty meal stimulation was associated with the administration of isometeptene. The mean values +/- S.D. of the follow parameters were evaluated: -gallbladder basal volume -gallbladder residual volume both after fatty meal and after the association with isometeptene -gallbladder maximum emptying percentage in two experiences. The results show that the isometeptene doesn't inhibit significantly the gallbladder emptying induced by a fatty meal.
D000328:Adult; D004041:Dietary Fats / Q000494:pharmacology; D005704:Gallbladder / Q000187:drug effects*; D006801:Humans; D008297:Male; D008744:Methylamines / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D013566:Sympathomimetics / Q000494:pharmacology*
D004041:Dietary Fats; D008744:Methylamines; D013566:Sympathomimetics; C008192:isometheptene
Effetti dell' isometeptene sulla contrazione della colecisti.