[Behavior of creatine in red blood cells and in plasma of children with chronic kidney insufficiency].
The creatine concentration of red blood cells and plasma in 44 children with chronic renal failure was studied and found to be significantly higher than in healthy children of comparable age. The creatine concentrations of the 31 hemodialyzed children surpassed those of the 13 conservatively treated patients by 30%. A statistically significant correlation was demonstrated between the serum creatinine level and the creatine concentrations in red blood cells. During hemodialysis the plasma creatine concentration decreases by half and reaches the predialysis values within 42 h after the end of dialysis, whereas the creatine concentration of the red cells does not change during a 4-5-h hemodialysis. With increasing number of hemodialyses the creatine concentration of red cells rises, suggesting an improvement of erythropoiesis.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003401:Creatine / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D004920:Erythropoiesis; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000628:therapy; D008297:Male; D006435:Renal Dialysis; D012737:Sex Factors
D003401:Creatine
Das Verhalten des Kreatins in roten Blutzellen und im Plasma von Kindern mit chronischer Niereninsuffizienz.