title: Modified distribution of lymphocyte subpopulation in blood and spleen from mice exposed to cadmium.
abstract: The effect of cadmium (Cd) on the lymphocyte subpopulation in peripheral blood and spleen was studied in ICR mice given a daily subcutaneous injection of 0.5 and 1.0 mg Cd/kg body weight for 5 days or mice fed with the drinking water containing 3, 30 and 300 ppm Cd for 10 weeks. The reduction of blood B lymphocytes observed in Cd-injected mice was accompanied by the increase of the number of splenic B lymphocytes. On the other hand in Cd-fed mice the reduction of blood T lymphocytes was found and associated with the increase of the number of splenic T lymphocytes. These findings suggest that circulating lymphocytes may redistribute differentially in lymphoid organs responded to the Cd exposure.
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001402:B-Lymphocytes / Q000187:drug effects*; D002105:Cadmium Poisoning / Q000276:immunology*; D002452:Cell Count; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013154:Spleen / Q000166:cytology*; D013601:T-Lymphocytes / Q000187:drug effects*