The intraperitoneal penetration of temocillin.
The intraperitoneal penetration of temocillin was studied following a 1 g iv injection in 28 patients undergoing elective gastrointestinal surgery. Temocillin penetrated rapidly and during the first hour post administration the peritoneal level was 48% of the serum level. The mean peritoneal level of temocillin over the period of the study (3.5 h) was 49.1 mg/l. It was concluded that 1 g of temocillin twice daily would achieve sufficiently high intraperitoneal levels to inhibit susceptible pathogens.
D000328:Adult; D000368:Aged; D001202:Ascitic Fluid / Q000378:metabolism*; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D010406:Penicillins / Q000008:administration & dosage / Q000378:metabolism*; D013997:Time Factors
D010406:Penicillins; C031367:temocillin