Characterization of a human anti-hCG antiserum: a proposed standard for laboratories involved with the development of hCG vaccines.
An antiserum (PC-81-1) was obtained from a man who developed antibodies against hCG during treatment for hypogonadism. The antiserum was unique in that its affinity for hCG was high (greater than 10(-10) M(-1] and its cross-reaction with hLH and the hCG-subunits was only 1-12.5% and 0.01%, respectively, of intact hCG. We propose that this human antiserum be used as a laboratory standard by investigators who are developing vaccines directed against hCG. The use of this standard in the proposed protocol will permit comparison of titers between laboratories. Lyophilized samples of antiserum PC-81-1 are available on request from the Population Council.
D000906:Antibodies / Q000276:immunology*; D006063:Chorionic Gonadotropin / Q000276:immunology*; D006801:Humans; D007006:Hypogonadism / Q000276:immunology; D007106:Immune Sera / Q000276:immunology; D007116:Immunization, Passive; D008297:Male; D014612:Vaccines / Q000592:standards*
D000906:Antibodies; D006063:Chorionic Gonadotropin; D007106:Immune Sera; D014612:Vaccines