Characterization of a "heteroclitic" cytotoxic lymphocyte clone: heterogeneity of receptors or signals?
In this work we report the isolation of a cloned CTL that recognizes three genetically distinct specificities. Of interest is the fact that the hierarchy of the strength of these specificities is dependent on the functional assay used for their detection. This suggests that either the specificities are the result of interactions with independent receptors or the cell can modulate signals from cross-reactive antigens into different functional responses.
D000818:Animals; D015478:Antigens, Heterophile / Q000235:genetics*; D000950:Antigens, Ly / Q000235:genetics; D002999:Clone Cells / Q000276:immunology; D005799:Genes, Dominant; D006183:H-2 Antigens / Q000235:genetics; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011948:Receptors, Antigen, T-Cell / Q000235:genetics*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D015478:Antigens, Heterophile; D000950:Antigens, Ly; D006183:H-2 Antigens; D011948:Receptors, Antigen, T-Cell