[Effects of single and combined administration FM-100 and cimetidine on serum gastrin levels in rats].
Antral pH was varied by an intragastric administration of a buffer solution with weak or strong acidity. There is a highly significant correlation between the intragastric pH and serum gastrin level (SG). FM-100 (800 mg/kg, i.d.) decreased SG independently of the intragastric pH, but cimetidine (400 mg/kg, i.d.) did not affect SG beyond the control range. The combination of FM-100 and cimetidine decreased SG significantly as compared with that after cimetidine alone; however, the SG was significantly higher than that after FM-100 alone. These results suggest that FM-100 inhibited gastrin release from the antrum independently of a feedback mechanism due to the intragastric pH, cimetidine increased SG dependently on the feedback mechanism, and FM-100 inhibited the increase in SG after cimetidine in pylorus-ligated rats.
D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology*; D002927:Cimetidine / Q000008:administration & dosage / Q000494:pharmacology*; D005755:Gastrins / Q000097:blood*; D006863:Hydrogen-Ion Concentration; D008026:Ligation; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D011706:Pyloric Antrum / Q000601:surgery; D051381:Rats; D011919:Rats, Inbred Strains
D000897:Anti-Ulcer Agents; D005755:Gastrins; D010936:Plant Extracts; C035049:FM 100; D002927:Cimetidine