Intraerythrocytic adaptation to anaemia in thalassaemia.
Red cell 2.3-diphosphoglycerate (2.3-DPG) response to anaemia is evaluated in 83 patients with different types of heterozygous thalassaemias, and 40 patients with chronic ferropenic anaemia and 120 healthy subjects are used as control groups. In heterozygous beta, beta delta, and alpha thalassaemic patients the 2.3 DPG concentration is appropriate for the degree of anaemia present.
D019794:2,3-Diphosphoglycerate; D000747:Anemia, Hypochromic / Q000097:blood*; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004912:Erythrocytes / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D013789:Thalassemia / Q000097:blood*
D004163:Diphosphoglyceric Acids; D019794:2,3-Diphosphoglycerate