[Ca2+, Mg2+, Zn2+ levels in histone fractions from normal and tumor cells].
Distribution of some bivalent cations (Ca2+, Mg2+, Zn2+) in histones isolated from healthy mice liver and ascitic hepatoma 22A cells has been investigated by atomic-absorption analysis. It has been shown that the content of these cations is higher in normal and diseased H3, H2B and H1 fractions and lower--in H2A; however, in the H4 fraction these metals are not detected. A significant increase of Ca2+, Mg2+ and Zn2+ levels has been established in ascitic H3, H2B and H1 fractions. An increase of bivalent cations (Ca2+, Mg2+, Zn2+) content in some histone fractions apparently is bound with the changes of histone--histone and histone--DNA interactions.
D000818:Animals; D002118:Calcium / Q000032:analysis*; D006657:Histones / Q000302:isolation & purification*; D008099:Liver / Q000032:analysis*; D008114:Liver Neoplasms, Experimental / Q000032:analysis*; D008274:Magnesium / Q000032:analysis*; D051379:Mice; D008809:Mice, Inbred C3H; D015032:Zinc / Q000032:analysis*
D006657:Histones; D008274:Magnesium; D015032:Zinc; D002118:Calcium
Soderzhanie Ca2+, Mg2+, Zn2+ vo fraktsiiakh gistonov normal'nykh i opukholevykh kletok.