Synthesis and biological action of some pyrido-[1,3]-diazepine and pyrido-[2, 3-d]-pyrimidine derivatives.
The following compounds were synthesized and tested for their action on the circulatory system and smooth muscle preparations: 3H,4,9-dihydropyrido-[2,3-e] [1,3]-diazepino-4,9-dione 1a, 3,4-dihydropyrido-[2,3-d]-pyrimidinone-4 2a and their derivatives: N-methylmorpholine 1b and 2b, N-methylopiperidine 1c and 2c, N-beta-hydroxy-gamma-morpholinopropyl 1d and 2d, and N-beta-diethylaminoethyl 1e and 2e. Compounds 1b-e and 2c showed weak hypotensive action in rats when given in a dose of 50 mg/kg, compounds 2d and 2e: 30 mg/kg and up.
D000818:Animals; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects; D007928:Lethal Dose 50; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects
D001381:Azepines; D011725:Pyridines; D011743:Pyrimidines