Enteric bacteria and HLA-B27 associated cell surface modification in patients with seronegative spondarthritis.
Cytotoxic studies indicate cross-reactivity between some enteric organisms and cells obtained from the majority of patients with ankylosing spondylitis. Preliminary studies suggest that the factor responsible for cross-reactivity may be generated by a bacterial plasmid. However, the mechanism mediating the interaction between the HLA-B27 positive cell and the bacterial antigen is at present unknown.
D003429:Cross Reactions; D003601:Cytotoxicity Tests, Immunologic; D004756:Enterobacteriaceae Infections / Q000150:complications* / Q000276:immunology; D006680:HLA Antigens / Q000276:immunology*; D015796:HLA-B27 Antigen; D006801:Humans; D008214:Lymphocytes / Q000276:immunology*; D013167:Spondylitis, Ankylosing / Q000175:diagnosis / Q000209:etiology* / Q000276:immunology
D006680:HLA Antigens; D015796:HLA-B27 Antigen