[Effect of a bioflavinoid (4-methylesculetin) on the response of calf hepatic arteries to serotonin in the presence of indomethacin].
The aim of this work is to study the mechanism by which 4-methylsculetin (4-Me) inhibits the serotonin induced contraction in smooth muscle. The effect of 4-Me, alone or associated with ascorbic acid, on basal tone and serotonin induced contraction of isolated hepatic artery strips have been studied. Experiments have been carried out in the presence of indomethacin (IN), specific inhibitor of prostaglandin-synthetase. IN suppressed the depressive effect of 4-Me on the serotonin dependent contraction. Therefore, it seems reasonable to conclude that the 4-Me influence could be mediated by prostaglandins release smooth muscle.
D000818:Animals; D002417:Cattle; D006499:Hepatic Artery / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D012603:Scopoletin / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology*; D014468:Umbelliferones / Q000494:pharmacology*
D014468:Umbelliferones; D012701:Serotonin; D012603:Scopoletin; D007213:Indomethacin
Influenza di un bioflavonoide (4-metilesculetolo) sulle risposte di arterie epatiche di vitello alla serotonina in presenza di indometacina.