title: Inhibition of non-neuronal cell proliferation in the goldfish visual pathway affects the regenerative capacity of the retina.
abstract: Proliferating cells associated with the visual pathway were found in the present study to affect the regenerative capacity of the goldfish retina following optic nerve injury. The contribution of these cells to the process of regeneration was investigated in the goldfish visual system by reducing their proliferation in the optic tract and tecta, using X-irradiation. The regenerative ability of the retina was then evaluated by the following parameters: sprouting from retinal explants, protein synthesis in the retina and accumulation of radiolabeled transported components in the tectum. X-irradiation of the visual system at an early stage of the regeneration process had a promoting effect whereas irradiation at a later stage resulted in a reduced capacity to regenerate. The results are discussed with respect to the possibility that proliferating cells, possibly glia, exert two contradictory contributions: an inhibitory effect at the site of injury, whereas distal to it, a supportive, perhaps trophic effect.
mesh_terms: D000818:Animals; D002455:Cell Division; D003530:Cyprinidae / Q000502:physiology*; D006054:Goldfish / Q000502:physiology*; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009473:Neuronal Plasticity; D012038:Regeneration; D012160:Retina / Q000378:metabolism / Q000502:physiology*; D013477:Superior Colliculi / Q000502:physiology; D014795:Visual Pathways / Q000502:physiology* / Q000528:radiation effects
chemical_list: D009419:Nerve Tissue Proteins