Von Willebrand factor has more than one binding site for platelets.
By the use of a series of monoclonal antibodies against platelet membrane glycoproteins (GP) and the von Willebrand factor (vWF), it is shown that thrombin-induced binding to GP IIb/IIIa involves a different site on vWF from ristocetin-induced binding to GP Ib.
D000911:Antibodies, Monoclonal / Q000502:physiology; D001665:Binding Sites; D001779:Blood Coagulation Factors / Q000502:physiology*; D001792:Blood Platelets / Q000502:physiology*; D006023:Glycoproteins / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D008565:Membrane Proteins / Q000276:immunology / Q000378:metabolism; D010973:Platelet Adhesiveness / Q000187:drug effects; D012310:Ristocetin / Q000494:pharmacology; D013917:Thrombin / Q000494:pharmacology; D014841:von Willebrand Factor / Q000502:physiology*
D000911:Antibodies, Monoclonal; D001779:Blood Coagulation Factors; D006023:Glycoproteins; D008565:Membrane Proteins; D014841:von Willebrand Factor; D012310:Ristocetin; D013917:Thrombin