Increased deposition of cholesterol in brain after electroconvulsive seizure.
Rats injected intracranially with cholesterol precursors and subjected to electroconvulsive seizures showed significantly higher levels of deposition of [4-14C]cholesterol into brain cholesterol than controls. The degree of incorporation was cholesterol greater than mevalonic acid greater than sodium acetate; in each case convulsed animals exceeded unshocked animals. Enhanced turnover of brain cholesterol with incorporation of circulating sterol may be associated with the etiology of convulsive seizures.
D000085:Acetates / Q000378:metabolism; D019342:Acetic Acid; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D004597:Electroshock; D005260:Female; D050356:Lipid Metabolism; D008798:Mevalonic Acid / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000209:etiology / Q000378:metabolism*
D000085:Acetates; D002784:Cholesterol; D019342:Acetic Acid; D008798:Mevalonic Acid