[Chromatin protein metabolism and phosphorylation in the cells of different parts of the brain and liver in rats under normal conditions and under motor load].
The relationship of intensive motional load with quantitative changes of the synthesis processes and phosphorylation in chromatin peptide fractions of varied polyacrylamide gel electrophoretic mobility from different rat brain structures and liver has been investigated. It has been established that the functional influences change not only the velocity of metabolism and phosphorylation but also the pattern of chromatin protein distribution. The new low molecular peptides differing in their electrophoretical mobility appear in chromatin of liver and neocortical neurons. The changes of the synthesis processes and phosphorylation typical of some fractions of the cerebral chromatin are variable and not so important as in the case of cytoplasmic proteins. The velocity of synthesis of the most proteins studied and the phosphorylation rate of some proteins increase in the neocortical neurones. The phosphorylation rate of separate low molecular peptides increases in the glial cells.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002843:Chromatin / Q000032:analysis / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D008099:Liver / Q000378:metabolism*; D009043:Motor Activity / Q000502:physiology*; D009457:Neuroglia / Q000378:metabolism; D009474:Neurons / Q000378:metabolism; D010446:Peptide Fragments / Q000032:analysis; D010766:Phosphorylation; D051381:Rats; D011919:Rats, Inbred Strains
D002843:Chromatin; D010446:Peptide Fragments
Obmen i fosforilirovanie belkov khromatina v kletkakh raznykh otdelov mozga i pecheni krys v normal'nykh usloviiakh i pri dvigatel'noĭ nagruzke.