Atropine inhibits bone resorption induced by high dose of zinc in rats.
A single oral administration of high amounts of zinc (Zn) induced hypocalcemia and bone resorption in rats. Atropine inhibited both effects thus supporting the hypothesis that the effect of Zn administration on bone results from the hypocalcemia mediated by acetylcholine.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D001862:Bone Resorption / Q000187:drug effects*; D001842:Bone and Bones / Q000378:metabolism; D002118:Calcium / Q000097:blood / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004336:Drug Antagonism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013431:Sulfates / Q000633:toxicity*; D015032:Zinc / Q000633:toxicity*; D019287:Zinc Sulfate
D013431:Sulfates; D019287:Zinc Sulfate; D001285:Atropine; D015032:Zinc; D002118:Calcium