The selection of penicillin-resistant staphylococci on murine skin.
The survival of staphylococci on mouse skin and on glass has been studied using paired isolates, isogenic but for a penicillinase plasmid. In general, there is a slight tendency for the penicillin-resistant isolates to survive better than the sensitive variants. In one staphylococcus it was possible to compare the effect of two different penicillinase plasmids. One gave a slightly enhanced survival but the other was detrimental to the host cell's survival. The effect seems not to be related to desiccation or to the effect of lipid.
D000818:Animals; D014644:Genetic Variation; D005898:Glass; D008297:Male; D051379:Mice; D010403:Penicillin Resistance; D010405:Penicillinase / Q000235:genetics; D010957:Plasmids; D012641:Selection, Genetic; D012867:Skin / Q000382:microbiology*; D013211:Staphylococcus aureus / Q000235:genetics*
D010405:Penicillinase