Antagonism of the 5-HT-induced bronchoconstriction in the cat.
In cats in which bronchoconstriction was induced and maintained by infusion of 5-HT, the bronchodilator effects of ketanserin, a related compound, cyproheptadine, clenbuterol and aminophylline were compared. The novel 5-HT2 antagonists ketanserin and R50970 were active in doses of about 10 nmol/kg, cyproheptadine was about 5 times less potent, but had a longer duration of action. Clenbuterol and aminophylline were only partially effective against 5-HT-induced bronchoconstriction. There was no reliable effect of the 5-HT antagonists against carbachol-induced bronchoconstriction.
D000818:Animals; D001980:Bronchi / Q000187:drug effects*; D002217:Carbachol / Q000494:pharmacology; D002415:Cats; D002976:Clenbuterol / Q000494:pharmacology; D003533:Cyproheptadine / Q000494:pharmacology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007650:Ketanserin; D008297:Male; D010880:Piperidines / Q000494:pharmacology; D011247:Pregnancy; D012701:Serotonin / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013806:Theophylline / Q000494:pharmacology
D010880:Piperidines; D012702:Serotonin Antagonists; D003533:Cyproheptadine; D012701:Serotonin; D002217:Carbachol; D007650:Ketanserin; D013806:Theophylline; D002976:Clenbuterol