[Pain-relieving action of voltaren and methindole determined in inflamed tissue].
As measured on an inflamed rat paw, voltaren raised the pain sensitivity threshold 4-5-fold, whereas on a non-inflamed paw, 2-2.5-fold. The effect seen was dose-dependent. Methindole yielded to voltaren as regards analgetic action determined on inflamed tissues. The method of mechanical irritation of inflamed tissues modified by the authors provides more complete information on analgetic action of non-steroidal anti-inflammatory agents as compared to other methods.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004008:Diclofenac / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation; D007213:Indomethacin / Q000627:therapeutic use*; D007249:Inflammation / Q000188:drug therapy*; D010146:Pain / Q000188:drug therapy*; D010648:Phenylacetates / Q000627:therapeutic use*; D010812:Physical Stimulation; D051381:Rats; D012684:Sensory Thresholds / Q000187:drug effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010648:Phenylacetates; D004008:Diclofenac; D007213:Indomethacin
Boleutoliaiushchee deĭstvie voltarena i metindola, opredeliaemoe na vospalennoĭ tkani.