Epidermal growth factor and tumor promoters prevent DNA fragmentation by different mechanisms.
Serum deprivation of C3H 10T 1/2 fibroblasts resulted in DNA fragmentation which was prevented by growth factors such as Epidermal Growth Factor or the tumor promoters, 12-0-tetradecanoyl-13-0-phorbol acetate and Dihydroteleocidin B. Palmityl carnitine, an inhibitor of Ca2+-phospholipid-dependent protein kinase C, reversed the effects of the tumor promoters, but not the effect of Epidermal Growth Factor.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D002999:Clone Cells; D003470:Culture Media; D004247:DNA / Q000378:metabolism*; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism; D007700:Kinetics; D008235:Lyngbya Toxins; D051379:Mice; D008809:Mice, Inbred C3H; D010172:Palmitoylcarnitine / Q000494:pharmacology; D010704:Phorbols / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D000470:Alkaloids; D002273:Carcinogens; D003470:Culture Media; D008235:Lyngbya Toxins; D010704:Phorbols; D010172:Palmitoylcarnitine; D004815:Epidermal Growth Factor; D004247:DNA; C022229:dihydroteleocidin B; D013755:Tetradecanoylphorbol Acetate