Cefotetan activity against Gram-negative aerobes and anaerobes.
The activity of cefotetan has been determined against strains of bacteroides, Haemophilus influenzae and klebsiella. The activity against bacteroides was lower than that of cefoxitin and moxalactam. The activity against multi-resistant klebsiella was very high, most strains requiring a concentration of 0.06 mg/l for inhibition. The stability to various beta-lactamases was demonstrated by testing the compound against beta-lactamase-producing H. influenzae and Enterobacteriaceae.
D000693:Anaerobiosis; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001439:Bacteroides / Q000187:drug effects; D015313:Cefotetan; D002511:Cephalosporins / Q000494:pharmacology*; D002513:Cephamycins / Q000494:pharmacology*; D006190:Haemophilus / Q000187:drug effects; D006868:Hydrolysis; D007709:Klebsiella / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D001618:beta-Lactamases / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D002513:Cephamycins; D015313:Cefotetan; D001618:beta-Lactamases