Comparison of expression of the fragile site at Xq27 in T and B lymphocytes.
We compared the fragile X (fraX) expression in T and B lymphocytes from four hemizygous males with fraX. Blood cultures were stimulated with a T cell mitogen (phytohemagglutinin:PHA) and with a B cell mitogen (pokeweed mitogen:PWM). A significant decrease in fraX expression was observed in cultures stimulated with PWM when compared to PHA-stimulated ones.
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000187:drug effects / Q000648:ultrastructure*; D005260:Female; D005600:Fragile X Syndrome / Q000235:genetics*; D006801:Humans; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D013601:T-Lymphocytes / Q000187:drug effects / Q000648:ultrastructure*; D014960:X Chromosome / Q000648:ultrastructure*
D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens