Locust adipokinetic hormone stimulates lipid mobilization in Manduca sexta.
Adipokinetic hormone, a decapeptide isolated from the locust, stimulates mobilization of diacylglycerols from the locust fat body and loading of the lipid transport protein, lipophorin. Injection of the synthetic locust adipokinetic hormone into a sphinx moth, Manduca sexta, causes lipid loading of lipophorin. The lipophorin decreases in density from 1.11 to 1.06 g/ml, and a soluble protein from the hemolymph (apolipophorin III) associates with the lipophorin particle. Administration of intermediate doses of hormone indicates that lipophorin is converted directly to the low density form; no appreciable amounts of intermediate density particles are formed.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism; D004075:Diglycerides / Q000378:metabolism; D006110:Grasshoppers; D006458:Hemolymph / Q000032:analysis; D007301:Insect Hormones / Q000302:isolation & purification / Q000494:pharmacology*; D007313:Insecta / Q000378:metabolism; D007915:Lepidoptera / Q000378:metabolism*; D008053:Lipid Mobilization / Q000187:drug effects*; D008074:Lipoproteins; D008297:Male; D008970:Molecular Weight; D009036:Moths / Q000378:metabolism*
D002352:Carrier Proteins; D004075:Diglycerides; D007301:Insect Hormones; D008074:Lipoproteins; C032830:lipophorin; C014956:adipokinetic hormone (locust)