Effect of irradiated haemophilus influenzae endotoxin preparations in mice.
A detoxified substance (rdLPS) was produced from Haemophilus influenzae endotoxin by ionizing radiation and its capacity to prevent attacks of dyspnoea elicited by endotoxin inhalation in mice has been studied. The rdLPS proved to be an effective stimulant of aspecific immune resistance of mice but it could only partly prevent attacks of dyspnoea.
D000818:Animals; D004417:Dyspnea / Q000276:immunology*; D004731:Endotoxins / Q000276:immunology* / Q000528:radiation effects; D006193:Haemophilus influenzae / Q000276:immunology*; D008070:Lipopolysaccharides / Q000276:immunology / Q000528:radiation effects; D008168:Lung / Q000276:immunology / Q000473:pathology; D051379:Mice; D011658:Pulmonary Fibrosis / Q000276:immunology / Q000473:pathology
D004731:Endotoxins; D008070:Lipopolysaccharides; C010797:tolerin