Systemic lupus erythematosus and lymphoma. A family study.
After 3 years of treatment with azathioprine and prednisone, immunoblastic lymphoma appeared in a patient with systemic lupus erythematosus. An increased incidence of immunological aberrations and malignancies was found in her family and their relation to the pathogenesis of this patient's diseases is discussed.
D000328:Adult; D001327:Autoimmune Diseases / Q000235:genetics; D001379:Azathioprine / Q000008:administration & dosage / Q000009:adverse effects*; D002648:Child; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D007958:Leukocyte Count; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000235:genetics / Q000276:immunology; D008228:Lymphoma, Non-Hodgkin / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D009369:Neoplasms / Q000235:genetics*; D010375:Pedigree; D011241:Prednisone / Q000008:administration & dosage / Q000009:adverse effects*; D013160:Splenic Neoplasms / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors
D001379:Azathioprine; D011241:Prednisone