Gm allotypes in Swedish myasthenia gravis patients.
Gm phenotype frequencies were examined in 112 Swedish myasthenia gravis patients. The G1m 1,2,3 phenotype frequency in the total patient material did not differ significantly from that found in the normal population. However, when patients were subdivided, three different patient groups were observed with regard to Gm1 frequency: (1) Thymoma patients having a low frequency of Gm1, (2) Non-thymoma patients with a mild disease having a low frequency of Gm1 and (3) Non-thymoma patients with a severe disease having a high frequency of Gm1. When patients were subdivided according to presence or absence of HLA-B8 and Gm1 respectively, severe symptoms were less frequent in the HLA-B8+, Gm(-1) group as compared to the HLA-B8+, Gm(+1) group. Furthermore, there was an increased frequency of sera with anti-immunoglobulins not inhibitable by pooled control immunoglobulins.
D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D001323:Autoantibodies / Q000235:genetics; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D009157:Myasthenia Gravis / Q000235:genetics / Q000276:immunology*; D010641:Phenotype; D011950:Receptors, Cholinergic / Q000276:immunology; D013548:Sweden / Q000208:ethnology; D013945:Thymoma / Q000235:genetics / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D006680:HLA Antigens; D007126:Immunoglobulin Allotypes; D011950:Receptors, Cholinergic