The major histocompatibility complex-restricted antigen receptor on T cells in mouse and man: identification of constant and variable peptides.
The variability of the MHC restricted receptor on murine T cells was examined by comparing tryptic peptide fingerprints of the receptor isolated fom three T cell hybridomas and a T cell tumor. Both variable and constant peptides were seen. Constant peptides were most apparent when comparing receptors from the same mouse strain. Peptide fingerprints of receptors from two independent T cell hybridomas with the same idiotype and specificity were identical. We also describe a molecule detected on the surface of a human T cell leukemia whose properties were identical to those reported for the MHC receptor on normal human T cells. The molecule was a dimer of 85,000-90,000 MW containing a 46,000 MW acidic alpha-chain and an unrelated 40,000 MW neutral beta-chain.
D000818:Animals; D002460:Cell Line; D006801:Humans; D006825:Hybridomas; D007945:Leukemia, Lymphoid / Q000276:immunology; D008285:Major Histocompatibility Complex; D051379:Mice; D008807:Mice, Inbred BALB C; D008970:Molecular Weight; D010455:Peptides / Q000032:analysis*; D011948:Receptors, Antigen, T-Cell / Q000032:analysis*; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology*; D014357:Trypsin
D010455:Peptides; D011948:Receptors, Antigen, T-Cell; D014357:Trypsin