A mathematical model for estimation of infarct size from serum creatine phosphokinase.
A mathematical model for kinetics of creatine phosphokinase (CK) after myocardial infarct is presented. The transport of CK from the infarct to the distribution space is modeled by a gamma variate. CK is released from the distribution space by a first-order process. The model permits simultaneous estimation of the disappearance rate parameter KD, the integrated appearance function, and the baseline from a set of observations of serum CK concentration.
D003201:Computers; D003402:Creatine Kinase / Q000097:blood*; D006801:Humans; D008955:Models, Cardiovascular; D009203:Myocardial Infarction / Q000175:diagnosis*
D003402:Creatine Kinase