title: Effects of subminimal inhibitory concentrations of aminoglycosides on the penicillinase production of Staphylococcus aureus.
abstract: The effects of subminimal inhibitory concentrations of kanamycin, amikacin and gentamicin on the production of penicillinase by Staphylococcus aureus were tested on 12 penicillin-resistant strains. Of the 36 experiments performed, 16 (44%) displayed an increase and 9 (25%) produced a decrease in the penicillinase activity of the strains. These effects were observed at concentrations ranging from 1:2 to 1:2,048 of the respective minimal inhibitory concentration, irrespective of the susceptibility of the strain to the aminoglycoside drug.
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D010405:Penicillinase / Q000096:biosynthesis*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000201:enzymology; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D010405:Penicillinase; D001618:beta-Lactamases