Influence of amphetamine on brown adipose thermogenesis.
Amphetamine (0.5, 1.0, 2.0 or 4.0 mg/kg) produced dose-dependent activation of interscapular brown-adipose tissue (IBAT) in female rats anesthetized with urethane (1.2 g/kg). Amphetamine-induced thermogenesis may reflect activation of beta-adrenergic receptors as evidenced by the rapid reversal of amphetamine-induced thermogenesis by propranolol (1.0 mg/kg). The potential relation of this effect to the anorexic property of amphetamine is discussed.
D002001:Adipose Tissue, Brown / Q000187:drug effects*; D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D005260:Female; D011433:Propranolol / Q000494:pharmacology; D051381:Rats
D000662:Amphetamines; D011433:Propranolol