[Stimulation of DNA synthesis in guinea pig spleen lymphocytes by staphylococcal peptidoglycan].
The mode of action of peptidoglycan on DNA synthesis in spleen lymphocytes of intact guinea-pigs was studied. It was found that peptidoglycan isolated from Staphylococcus aureus 2287 is mainly mitogenic for B lymphocytes that have IgG receptors on their surface. In contrast to lipopolysaccharide from Salmonella typhimurium, it seems that peptidoglycan is also mitogenic for less differentiated B cells.
D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects*; D006168:Guinea Pigs; D008213:Lymphocyte Activation; D008934:Mitogens / Q000494:pharmacology; D010457:Peptidoglycan / Q000276:immunology*; D013211:Staphylococcus aureus / Q000276:immunology*
D008934:Mitogens; D010457:Peptidoglycan
Stimuliatsiia sinteza DNK v limfotsitakh selezenki morskikh svinok peptidoglikanom stafilokokka.