title: T cell mediated polyclonal B cell activation induced by cell-bound fetal calf serum.
abstract: In vitro exposure of spleen cells to fetal calf serum prior to extensive washing and injection into syngeneic recipients was found to markedly increase in vitro responses to both trinitrophenyl-Ficoll and sheep erythrocytes, increase in vitro spontaneous (background) direct plaque-forming cell responses, and cause a tenfold increase in spontaneous IgM production in vitro. This study demonstrates T cell mediated polyclonal B cell activation which was manifested both in vitro and in vivo.
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002417:Cattle; D002478:Cells, Cultured; D005260:Female; D005312:Fetal Blood; D007116:Immunization, Passive; D008070:Lipopolysaccharides / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008811:Mice, Inbred DBA; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D008070:Lipopolysaccharides