[The effect of aerosolization on the changes in major biological properties of the vaccine strain of Francisella tularensis].
The exposure of F. tularensis vaccine strain 15/10 in the form of aerosol for more than 10 minutes results in the decrease of its virulence, immunogenicity and the content of species-specific antigen and in the increase of the dissociation level. Proceeding from this fact, during aerosol immunization with this vaccine strain exposure must not exceed 5 minutes for unstabilized aerosol and 10 minutes for aerosol stabilized with 5% glycerin. Under these conditions the properties of F. tularensis strain 15/10 are retained practically on the initial level.
D000336:Aerosols; D000818:Animals; D000942:Antigens, Bacterial / Q000032:analysis; D001428:Bacterial Vaccines / Q000008:administration & dosage*; D005604:Francisella tularensis / Q000276:immunology* / Q000472:pathogenicity; D007279:Injections, Subcutaneous; D051379:Mice; D014406:Tularemia / Q000517:prevention & control*; D014611:Vaccination / Q000379:methods*; D014774:Virulence
D000336:Aerosols; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines
Vliianie aérozolirovaniia na izmenenie osnovnykh biologicheskikh svoĭstv vaktsinnogo shtamma Francisella tularensis.