[Effect of 5 alpha-androstane-3 beta,17 beta-diol on estradiol-17 beta reception in pituitary cytosol of male and female rats].
The strongest inhibiting effect of estradiol-17 beta (E2) reception in the cytosol fraction of male and female rat pituitary is exerted by 5 alpha-androstane-3 beta, 17 beta-diol (3 beta-diol). Sucrose density linear gradient centrifugation of pituitary cytosol preincubated with [3H]E2 in the presence of 3 beta-diol demonstrated that in the pituitary cytosol of rats of both sexes 3 beta-diol affects the non-specific binding of [3H]E2 around 4.5 S, when taken both at high and at low concentrations. The specific binding of [3H]E2 at 8.0-8.5 S is inhibited only by high concentrations of 3 beta-diol. It is assumed that 3 beta-diol can take part in the regulation of E2 reception in male and female rat hypophyses.
D015113:Androstane-3,17-diol / Q000494:pharmacology*; D000732:Androstanols / Q000494:pharmacology*; D000818:Animals; D003600:Cytosol / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D007700:Kinetics; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D011959:Receptors, Estradiol; D011960:Receptors, Estrogen / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism*; D012737:Sex Factors
D000732:Androstanols; D011959:Receptors, Estradiol; D011960:Receptors, Estrogen; D015113:Androstane-3,17-diol; D004958:Estradiol
Vliianie 5al'fa-androstan-3beta, 17beta-diola na retseptsiiu éstradiola-17beta v tsitozole gipofiza samtsov i samok krys.