Experimentally induced susceptibility to audiogenic seizure.
By injecting metal ions and pyridoxal-5'-phosphate, we made the normal mouse prone to sound-induced epilepsy. We showed that the levels of glutamate and aspartate in its inferior colliculus were elevated and the concentration of gamma-aminobutyrate was lowered. The time course of audiogenic susceptibility after the treatment was closely mirrored by changes in the concentrations of glutamate, aspartate, and gamma-aminobutyrate in the inferior colliculus.
D000161:Acoustic Stimulation; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D004198:Disease Susceptibility; D007245:Inferior Colliculi / Q000032:analysis; D051379:Mice; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D012640:Seizures / Q000503:physiopathology*; D013997:Time Factors
D000596:Amino Acids