Interaction of thyrotropin (TSH) and gonadotropins in the function of genital organs I. Investigations in the frog.
Earlier data indicate that TSH, which has a structure similar to that of gonadotropins, is able to evoke ejaculation in the frog (Galli-Mainini reaction). The present experiments provide evidence that TSH, in a dose that by itself is ineffective, is able to potentiate the effect of HCG. This action of TSH is more pronounced if the drug is administered prior to HCG; it is less evident upon simultaneous administration. Since FSH + LH has similar effects the experiments provide further evidence for the concept that TSH acts like gonadotropin in this system.
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D004357:Drug Synergism; D004542:Ejaculation / Q000187:drug effects*; D006062:Gonadotropins / Q000494:pharmacology*; D008297:Male; D011893:Rana esculenta; D013972:Thyrotropin / Q000494:pharmacology*
D006063:Chorionic Gonadotropin; D006062:Gonadotropins; D013972:Thyrotropin