Peripheral T cell lymphoma (immunoblastic sarcoma of T cell type): an immuno-ultrastructural study.
Use of monoclonal antibodies directed against T cell antigens for the phenotypic characterization of neoplastic lymphoid cells in peripheral T cell lymphomas is described. Studies of cryostat sections revealed the distribution of T cell subsets in nodal and extranodal infiltrates, and immuno-ultrastructural techniques demonstrated discrete localization of T cell antigens to the cytoplasmic membranes of neoplastic cells. Although histologically similar, the tumors appeared heterogeneous as to their immunologic phenotype, with the majority demonstrating markers for T helper/inducer lymphocytes.
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D006801:Humans; D008223:Lymphoma / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D008228:Lymphoma, Non-Hodgkin / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm