A liquid chromatographic method for the determination of AY-25,712, a lipid-lowering agent, in serum.
We report a sensitive and specific method for the determination of AY-25,712 concentrations in rat, dog and human serum by liquid chromatography with UV detection. The detection limit is 25 ng/mL, based on 2 mL of serum or plasma. The method has been validated in human volunteers receiving single oral doses of AY-25,712 (25 to 900 mg).
D000818:Animals; D002853:Chromatography, Liquid / Q000379:methods; D005663:Furans / Q000097:blood*; D006801:Humans; D000960:Hypolipidemic Agents / Q000097:blood*; D008297:Male; D051381:Rats
D005663:Furans; D000960:Hypolipidemic Agents; C036804:acifran