An immunological classification of ovine lymphomas.
Sporadic ovine lymphoma cells were identified as T or B lymphocytes with a T cell-specific antiserum or by detecting surface immunoglobulin. Lymphomas were classified as being of T or B cell origin if 60 per cent, or more, of the cells were of the respective type. Of 16 lymphomas, 6 were T cell and 6 were B cell derived. In one lymphoma more than 60 per cent of the cells were identified as both T and B cells. In the other 3 lymphomas neither T nor B cells reached this value; 2 of these had negligible T and B cell numbers and were classified as null cell lymphomas. A relationship was seen between the immunological and anatomical classifications of the lymphomas in that all the T cell lymphomas were of multicentric distribution while 4 of the 6 B cell neoplasms were confined to the alimentary tract and its associated lymphoid tissue. In contrast, there was no relationship between the immunological and histological classifications of the lymphomas.
D000818:Animals; D001402:B-Lymphocytes; D008223:Lymphoma / Q000145:classification / Q000276:immunology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000145:classification* / Q000276:immunology; D013601:T-Lymphocytes