Effect of the orally absorbed dopamine analogue N-methyldopamine diisobutyric ester on plasma prolactin levels.
The effect of the diisobutyric ester of N-methyldopamine (Ibopamine) on plasma prolactin levels was investigated in normoprolactinaemic subjects and in hyperprolactinaemic patients with prolactin-secreting tumours or idiopathic hyperprolactinaemia. In hyperprolactinaemic states oral Ibopamine 50 mg induced a significant decrease in elevated plasma prolactin (PRL) levels, 30, 60 and 90 min after administration. The peak effect occurred at 90 min when the mean PRL level was 61% of its basal values.
D000328:Adult; D003846:Deoxyepinephrine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004298:Dopamine / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D009200:Myocardial Contraction / Q000187:drug effects; D011388:Prolactin / Q000097:blood*; D013997:Time Factors
C023487:ibopamine; D011388:Prolactin; D003846:Deoxyepinephrine; D004298:Dopamine