T and B lymphocyte subsets in fenoprofen nephropathy.
Renal failure due to combined acute interstitial nephritis and minimal-change glomerulopathy is reported in two patients after fenoprofen therapy. In the interstitial infiltrates, T lymphocytes predominated over B lymphocytes in a ratio of four to one. The majority of B lymphocytes present were IgE-bearing cells. Among the T cells, the ratio of cytotoxic/suppressor cells to helper-inducer cells was three to one. Repeated renal biopsy in one patient after steroid-induced clinical remission demonstrated resolution of the inflammatory infiltrate and restoration of normal glomerular foot processes. The theoretic and practical implications of these findings are discussed.
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000473:pathology; D001402:B-Lymphocytes / Q000648:ultrastructure*; D005260:Female; D005279:Fenoprofen / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced; D009402:Nephrosis, Lipoid / Q000139:chemically induced; D010666:Phenylpropionates / Q000009:adverse effects*; D013601:T-Lymphocytes / Q000648:ultrastructure*; D013602:T-Lymphocytes, Cytotoxic / Q000648:ultrastructure
D010666:Phenylpropionates; D005279:Fenoprofen