title: Constitutive production of Interleukin-1 by the human continuous cell line, CM-S.
abstract: Supernatants from the human continuous cell line, CM-S, have been tested for Interleukin-1 (IL-1) activity and found to constitutively elaborate this factor. The CM-S-produced IL-1 activity has been partially purified and shown to be similar to IL-1 produced by human and mouse peripheral blood macrophages. To the best of our knowledge this is the first continuous human cell line reported that produces this monokine.
mesh_terms: D002460:Cell Line; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis* / Q000302:isolation & purification / Q000502:physiology; D007376:Interleukin-2 / Q000032:analysis / Q000096:biosynthesis; D008213:Lymphocyte Activation
chemical_list: D007375:Interleukin-1; D007376:Interleukin-2