title: Resistance to Pseudomonas aeruginosa septicemia in mice after transfer of immune spleen cells.
abstract: The resistance to P. aeruginosa septicemia was studied in mice after transfer of immune spleen cells from donors vaccinated with P. aeruginosa slime-extract. The protective capacity of these cells appeared in donors within 3 days after immunization and reached a maximum between day 4 and 6. Then it rapidly declined and disappeared on the 9th day after vaccination. This capacity of spleen cells from donors immunized several times with slime-extract was lasting longer than in the former group and decreased on day 9-11 after the last vaccination. However, the recipients were not protected against infection if the donor immune spleen cells were pretreated with anti-Thy 1.2 monoclonal antibodies. Moreover, it was found that the transfer of cells from vaccinated donors to nonimmune mice inoculated with P. aeruginosa enhanced a steady decrease of the number of viable organisms in the spleens of the recipients. The immunity conferred on the recipient mice was highly specific.
mesh_terms: D000818:Animals; D005260:Female; D007111:Immunity, Cellular; D007116:Immunization, Passive; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011552:Pseudomonas Infections / Q000276:immunology*; D018805:Sepsis / Q000276:immunology*; D013154:Spleen / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors