Clinical features of patients with antibodies directed against proliferating cell nuclear antigen.
The clinical and serologic features of 7 patients whose sera contained antibodies directed against proliferating cell nuclear antigen (anti-PCNA) were studied. Five of the patients had systemic lupus erythematosus (SLE), 1 had idiopathic diffuse proliferative glomerulonephritis, and 1 had seronegative arthritis. In a study of various rheumatic diseases, anti-PCNA was found in 2% of SLE sera but was not found in the sera of 100 rheumatoid arthritis patients, 20 mixed connective tissue disease patients, or 50 diffuse scleroderma patients. Patients with anti-PCNA had no history of hemolytic anemia, leukopenia, thrombocytopenia, or pleuro-pericarditis. Evidence that the production of anti-PCNA antibodies is sensitive to corticosteroid therapy is also presented.
D000328:Adult; D000974:Antibodies, Antinuclear / Q000032:analysis*; D000941:Antigens / Q000276:immunology*; D034961:Antigens, Nuclear; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis; D001324:Autoantigens; D002455:Cell Division; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000175:diagnosis / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D008947:Mixed Connective Tissue Disease / Q000276:immunology; D009698:Nucleoproteins / Q000276:immunology*; D017411:Ribonucleoproteins, Small Nuclear; D012595:Scleroderma, Systemic / Q000276:immunology; D055517:snRNP Core Proteins
D000974:Antibodies, Antinuclear; D000941:Antigens; D034961:Antigens, Nuclear; D001323:Autoantibodies; D001324:Autoantigens; D009698:Nucleoproteins; D017411:Ribonucleoproteins, Small Nuclear; D055517:snRNP Core Proteins