[Partial laryngectomy following combined FAR therapy--evaluation of survival rate and region of recurrence studied by an antomical map].
The clinical records of 75 consecutive patients undergoing partial laryngectomy at Kyushu University Hospital were reviewed. Almost all the patients were treated by combined preoperative FAR therapy (5 FU, vitamin A and irradiation). Among 57 patients, the (estimated) five year survival rate was 76%. The cure rate among 18 patients in whom horizontal laryngectomy was done was high (75%) compared with results presented in other reports. This may be ascribable to the preoperative FAR therapy. Anatomically, critical regions of recurrence were the subglottic region and anterior commissure in vertical partial laryngectomy.
D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007822:Laryngeal Neoplasms / Q000401:mortality* / Q000473:pathology / Q000601:surgery / Q000628:therapy; D007825:Laryngectomy / Q000379:methods / Q000401:mortality*; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D014801:Vitamin A / Q000008:administration & dosage
D014801:Vitamin A; D005472:Fluorouracil