Tryptophan potentiation of the late cysteine preventive effects in carbon tetrachloride-induced necrosis.
Carbon tetrachloride (CCl4) (1 ml/kg/ip) induces a very intense necrotic effect on rat liver at 24 hr after administration. Cysteine (950 mg/kg/po) given 6 h after CCl4 exerted a very weak preventive effect on CCl4-induced necrosis, while tryptophan (300 mg/kg/po) did not. When both aminoacids are given together a very marked protective effect is observed. A possible participation of protein synthesis stimulation in the late protective effects of cysteine on CCl4-induced liver necrosis is discussed.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control*; D056486:Chemical and Drug Induced Liver Injury; D003545:Cysteine / Q000494:pharmacology*; D004357:Drug Synergism; D008107:Liver Diseases / Q000517:prevention & control*; D008297:Male; D009336:Necrosis / Q000139:chemically induced / Q000517:prevention & control; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014364:Tryptophan / Q000494:pharmacology*
D014364:Tryptophan; D003545:Cysteine