Development of new hypoxic cell sensitizers: amides of nitrobenzoic acid with spermidine and spermine.
New type hypoxic cell sensitizers, N1,N10-bis(4-nitrobenzoyl)spermidine (1) and N1,N14-bis(4-nitrobenzoyl)-spermine (2), have been developed. These compounds were shown to be more effective radiosensitizers to hypoxic cells than misonidazole (3).
D002470:Cell Survival / Q000187:drug effects; D006367:HeLa Cells / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D000860:Hypoxia / Q000473:pathology*; D008920:Misonidazole / Q000494:pharmacology; D011838:Radiation-Sensitizing Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D013095:Spermidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013096:Spermine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology
D011838:Radiation-Sensitizing Agents; D013096:Spermine; C039397:N(1),N(10)-bis(4-nitrobenzoyl)spermidine; C039398:N(1),N(14)-bis(4-nitrobenzoyl)spermine; D008920:Misonidazole; D013095:Spermidine