Serum gp70 production regulated by a gene on murine chromosome 7.
We mated 129 mice (prototype strain of GIX+) with C57BL/6 mice (prototype strain of GIX-) and thereby identified the gene controlling enhancement of serum gp70 production after lipopolysaccharide (LPS) injection. This gene has been tentatively designated Sgp-2. Sgp-2 is linked with the Hbb locus on chromosome 7. The estimated frequency of recombination between Sgp-2 and Hbb in this setting is about 20%.
D000818:Animals; D002875:Chromosomes / Q000502:physiology; D003433:Crosses, Genetic; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006023:Glycoproteins / Q000097:blood / Q000235:genetics*; D008070:Lipopolysaccharides; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D013045:Species Specificity
D006023:Glycoproteins; D008070:Lipopolysaccharides; C033589:glycoprotein gp70, murine serum