title: A thermally driven interconversion of B and Z-dna.
abstract: CD and IR studies show that poly(dG-dMeC) in dilute Mg++ and Na+ solutions (e.g., 2 mM Mg++ and 55 mM Na+) undergoes reversible thermal interconversion of B and Z forms, in contrast to previous reports that the transition is independent of temperature and has an enthalpy change of zero. The B conformation is stable under the above conditions at lower temperature (approximately 5 degrees) and the Z form above approximately 20 degrees. The conversion is relatively slow in both directions, but is more rapid in the Z leads to B direction.
mesh_terms: D002942:Circular Dichroism; D004247:DNA; D007700:Kinetics; D008274:Magnesium; D009690:Nucleic Acid Conformation; D011089:Polydeoxyribonucleotides; D013055:Spectrophotometry, Infrared; D013696:Temperature
chemical_list: D011089:Polydeoxyribonucleotides; C029988:poly(dG-m(5)dC).poly(dG-m(5)dC); D004247:DNA; D008274:Magnesium