Immunogenetic and immunologic aspects of gliosarcoma growth in rats.
Growth of the chemically induced, transplantable rat brain tumor gliosarcoma 9L (GS-9L) is under immunogenetic control. Both susceptible and resistant rats produce an immune response to the tumor, but the response is qualitatively different in the two groups. The intraperitoneal administration of gliosarcoma-9L cells in resistant KGH rats causes the production of cytotoxic lymphocytes and macrophages, and in susceptible F344 rats suppressor lymphocytes are produced. After gliosarcoma-9L cells were administered to (KGH x F344)F1 and backcross rats, tumor susceptibility or resistance and the nature of the immune response correlated well with the histocompatibility type, indicating the parallel genetic control of both traits. However, a second gene or gene complex, not linked to the major histocompatibility complex, may participate in the regulation of tumor growth.
D000818:Animals; D001202:Ascitic Fluid / Q000276:immunology; D001932:Brain Neoplasms / Q000235:genetics / Q000276:immunology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D003433:Crosses, Genetic; D003602:Cytotoxicity, Immunologic; D005910:Glioma / Q000235:genetics / Q000276:immunology*; D006084:Graft Rejection; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology; D008264:Macrophages / Q000276:immunology / Q000473:pathology; D008285:Major Histocompatibility Complex; D051381:Rats; D011914:Rats, Inbred BN; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D013045:Species Specificity