[Response of isolated coronary artery segments to serotonin in the presence of a flavinoid, indomethacin and acetylsalicylate].
The aim of this work is to study the mechanism by which 4-metilesculetin (4-Me) cause the relaxation or inhibit the serotonin induced contraction in the smooth muscle. The effect of 4-Me, alone or associated with ascorbic-acid, on basal tone and serotonin induced contraction of isolated coronary strips have been studied. Experiments have been carried out in the presence of indomethacin (IN), specific inhibitor of prostaglandin synthetase. IN-decreased, but did not abolished, the 4-Me induced relaxation and reduced or suppressed the depressive effect of 4-Me on the serotonin dependent contraction. Therefore, it seems reasonable to conclude that the 4-Me influence could be mediated by prostaglandins release in the smooth muscle.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001241:Aspirin / Q000494:pharmacology*; D002417:Cattle; D003331:Coronary Vessels / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D012603:Scopoletin / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology*; D014468:Umbelliferones / Q000494:pharmacology*
D014468:Umbelliferones; D012701:Serotonin; D012603:Scopoletin; D001205:Ascorbic Acid; D001241:Aspirin; D007213:Indomethacin
Risposte di segmenti di arterie coronarie isolate alla serotonina in presenza di un flavonoide, di indometacina e di acetilsalicilato.