Comparison of three routes of administration of a water soluble anthelmintic: levamisole.
The plasma concentration of levamisole was determined by liquid chromatography in three groups of 20 heifers treated with levamisole by intramuscular administration, drenching and in drinking water respectively. Maximum concentrations were observed at three hours (1.10 +/- 0.16 microgram/ml) and six hours (0.64 +/- 0.06 microgram/ml) after intramuscular administration and drenching respectively. Large individual variations in plasma concentrations were observed following treatment in drinking water with four animals showing maximum concentrations below 0.1 microgram/ml. Variation in water intake therefore makes the latter method less reliable.
D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D002417:Cattle / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D005260:Female; D007273:Injections, Intramuscular / Q000662:veterinary; D007978:Levamisole / Q000008:administration & dosage* / Q000097:blood; D012995:Solubility; D014867:Water
D014867:Water; D007978:Levamisole