[Distribution of lymphocyte subpopulation and natural killer activity in gastric cancer tissue, normal stomach and various tissues of gastric cancer patients].
Natural killer activity of lymphocyte against M-HeLa or MKN-28 cells was measured in the gastric cancer tissue, regional lymph nodes, spleen and peripheral blood, and also the influences of injection of Nocardia CWS into the tumor was studied. Tumor infiltrating lymphocyte showed higher rates of T and T gamma cells than the lymphocyte of normal gastric tissue, nearly the same value as the lymphocyte in peripheral blood. NK activity of the lymphocyte in the peripheral blood of the gastric cancer patient showed a significant decrease compared to that of the normal subject. NK activity of the tumor infiltrating lymphocyte was markedly lower than that of the lymphocyte in peripheral blood, and was at the same level as that of the normal stomach and the lymph node. Endoscopic injection of N-CWS into the gastric cancer tissue intensified the cytotoxicity of lymphocytes in the cancer tissue and regional lymph nodes to MKN-28 cells derived from gastric cancer 5 to 17 days later, however, the activity against M-HeLa did not augment. Human fibroblast interferon (interferon beta) increased NK activity of lymphocytes in peripheral blood and spleen, but showed no influence on the activity of lymphocytes in the gastric cancer tissue and the regional lymph nodes.
D000328:Adult; D000368:Aged; D000920:Antibody-Dependent Cell Cytotoxicity; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000276:immunology*; D008214:Lymphocytes / Q000145:classification / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D013270:Stomach / Q000276:immunology*; D013274:Stomach Neoplasms / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D007370:Interferon Type I