title: Genetic studies in ankylosing spondylitis.
abstract: It is likely that ankylosing spondylitis is genetically heterogeneous. The evidence favours the gene for HLA-B27 being the major genetic factor responsible for susceptibility. The finding of a greater prevalence of disease in B27 positive first-degree male relatives of probands than in random B27 positive controls, suggests the existence of other genes for susceptibility, possibly HLA-linked.
mesh_terms: D000328:Adult; D000368:Aged; D004739:England; D005260:Female; D005828:Genetics, Population; D006680:HLA Antigens / Q000235:genetics*; D015796:HLA-B27 Antigen; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D013167:Spondylitis, Ankylosing / Q000000981:diagnostic imaging / Q000235:genetics* / Q000276:immunology
chemical_list: D006680:HLA Antigens; D015796:HLA-B27 Antigen