Chemical structures of angiotensins formed by incubating plasma with the kidney and the corpuscles of Stannius in the chum salmon, Oncorhynchus keta.
The chemical structures of salmon angiotensins produced by incubating tissue extract of the kidney or the corpuscles of Stannius (CS) with homologous plasma are proposed. Two angiotensins, [Asp1, Val5, Asn9] and [Asn1, Val5, Asn9] angiotensin I, were proposed from both kidney and CS incubations by amino acid analysis and the fluorescent peptide-mapping techniques. CS angiotensins were not organ specific, because these two angiotensins were produced by both kidney and CS incubations in a ratio of 1:2 under the same conditions. Whether [Asp1, Val5, Asn9] angiotensin I is a naturally occurring form remains to be clarified; however, [Asn1, Val5, Asn9] angiotensin I may be the major form of angiotensin formed from plasma by salmon kidney and CS.
D000595:Amino Acid Sequence; D000809:Angiotensins / Q000008:administration & dosage / Q000302:isolation & purification; D000818:Animals; D001794:Blood Pressure; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D005260:Female; D007668:Kidney / Q000032:analysis / Q000378:metabolism*; D009928:Organ Specificity; D010455:Peptides / Q000032:analysis; D010949:Plasma / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012474:Salmon / Q000378:metabolism*
D000809:Angiotensins; D010455:Peptides