Preparation and quality control of 99mTc-calciumgluconate.
A procedure for the labelling of lyophilised Sn-Ca-Gluconate by a 99mTc instant technique was developed. Paper and TLC chromatography and low-voltage electrophoresis were used for the determination of the labelling yield which reached between 95 to 98%. The biodistribution was followed in white (albino) rats. About 25 to 35% of the total activity of the compound was retained in the kidneys one hour after its i.v. injection.
D000818:Animals; D004355:Drug Stability; D005942:Gluconates / Q000138:chemical synthesis*; D007553:Isotope Labeling; D007668:Kidney / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D011786:Quality Control; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium / Q000138:chemical synthesis*; D014018:Tissue Distribution
D005942:Gluconates; D015609:Organotechnetium Compounds; C035148:technetium Tc 99m tin gluconate; D013667:Technetium