Effects of metronidazole (Flagyl) on the determination of serum ASAT on the SMA 12/60 Auto Analyser.
Therapeutic serum concentrations of metronidazole will lead to under-estimation of ASAT activity when a SMA 12/60 Auto Analyser is used. This interference is due to metronidazole entering the colorimeter through the dialyser membrane in the SMA 12/60 Auto Analyser. This drug is one of the few with a relatively high therapeutic serum concentration, absorbing light in the 340 nm range. Metronidazole will similarily affect other 340 nm methods (LDH, ALAT) available on the SMA 12/60. This interference with metronidazole on the SMA 12/60 can easily be solved by the introduction of a separate serum blank channel for the 340 nm methods.
D001219:Aspartate Aminotransferases / Q000097:blood*; D001322:Autoanalysis; D006801:Humans; D007275:Injections, Intravenous; D008795:Metronidazole / Q000008:administration & dosage / Q000097:blood*
D008795:Metronidazole; D001219:Aspartate Aminotransferases