[Use of the antioxidant ionol to prevent damage to the heart from prolonged administration of antitubercular preparations].
Prolonged administration of isoniazid, protionamide and rifampicin to white rats is accompanied by marked depression of myocardial contractile function determined by the distress of membranous mechanisms of calcium transport because of excessive activation of lipid peroxidation in cardiomyocyte biomembranes. Administration of ionol coupled with antituberculous drugs prevents their cardiotoxic effects.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000009:adverse effects*; D002084:Butylated Hydroxytoluene / Q000627:therapeutic use*; D006331:Heart Diseases / Q000139:chemically induced* / Q000517:prevention & control; D007538:Isoniazid / Q000009:adverse effects; D008297:Male; D011515:Prothionamide / Q000009:adverse effects; D051381:Rats; D012293:Rifampin / Q000009:adverse effects; D013997:Time Factors
D000975:Antioxidants; D000995:Antitubercular Agents; D002084:Butylated Hydroxytoluene; D011515:Prothionamide; D007538:Isoniazid; D012293:Rifampin
Ispol'zovanie antioksidanta ionola dlia preduprezhdenia povrezhdeniĭ serdtsa, vyzvannykh dlitel'nym vvedeniem protivotuberkuleznykh preparatov.