Hypoglycemia induced by the interaction of chlorpropamide and co-trimoxazole.
Sulfonylureas hypoglycemic action may be potentiated by sulfonamides. This case report describes a 69-year-old female with a hypoglycemic episode suggestive of an interaction between chlorpropamide and sulfamethoxazole (co-trimoxazole). The patient had no renal or liver dysfunction. This interaction is rare but one should be aware of it, especially with combination products.
D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D002747:Chlorpropamide / Q000009:adverse effects*; D004338:Drug Combinations / Q000009:adverse effects; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D013420:Sulfamethoxazole / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D001786:Blood Glucose; D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D014295:Trimethoprim; D013420:Sulfamethoxazole; D002747:Chlorpropamide