Screening for impurities in butoprozine.
The purity analysis of butoprozine is described. Both gas chromatography-mass spectrometry (GC-MS) and high pressure liquid chromatography (HPLC) with UV-vis detection (conventional and multichannel) were used. In the butoprozine example disadvantages for both techniques became apparent: incorrect conclusions with regard to the purity of the drug would have been drawn if only one of these chromatographic techniques had been used. GC-MS allowed the identification of an impurity not found by HPLC.
D000638:Amiodarone / Q000031:analogs & derivatives / Q000032:analysis*; D001572:Benzofurans / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004340:Drug Contamination; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
D001572:Benzofurans; C014921:butoprozine; D000638:Amiodarone