A proliferation-associated rat cell surface antigen recognized by a murine monoclonal antibody.
B3 murine IgG1 monoclonal antibody against BC47 rat bladder cancer detected an antigen distributed on the cell surface of neoplastic cells and proliferating normal tissue cells. The percentage of B3 antigen-positive cells in lymphocytes was increased by mitogen stimulation. The molecular weight of the antigen was 130,000 or 140,000 daltons.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000032:analysis*; D000954:Antigens, Surface / Q000032:analysis*; D001402:B-Lymphocytes / Q000276:immunology; D002455:Cell Division; D002460:Cell Line; D002478:Cells, Cultured; D004591:Electrophoresis, Polyacrylamide Gel; D004847:Epithelial Cells; D004848:Epithelium / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D011912:Rats, Inbred ACI; D011916:Rats, Inbred F344; D013601:T-Lymphocytes / Q000276:immunology; D001749:Urinary Bladder Neoplasms / Q000276:immunology* / Q000473:pathology
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D000954:Antigens, Surface