Neonatal lupus erythematosus: five new cases with HLA typing.
In two of five infants with neonatal lupus erythematosus the signs of the disease did not appear until the children had been exposed to direct sunlight. This suggests that an environmental factor may be required for the development of the disease in some patients. Three of the five patients, together with their mothers, had the HLA (histocompatibility) antigens A1 and B8, which supports the concept that individuals may be genetically susceptible to lupus erythematosus.
D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D015788:HLA-A1 Antigen; D015795:HLA-B8 Antigen; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000235:genetics*; D008180:Lupus Erythematosus, Systemic / Q000235:genetics*; D008297:Male
D006680:HLA Antigens; D015788:HLA-A1 Antigen; D015795:HLA-B8 Antigen