Use of the cricket embryo (Acheta domesticus) as an invertebrate teratology model.
Embryos of the cricket Acheta domesticus (L.) have been shown by bioassay to develop gross morphological abnormalities after exposure to a number of complex organic mixtures as well as to display a critical period of teratogen sensitivity and an ability to metabolize xenobiotics during development. Because the assay is simple, inexpensive, short-term (less than two weeks), and objective, it could be useful as an in vivo screen in a hierarchical approach to teratogen detection. Further investigation of cricket embryo responses to known teratogens is needed to establish the predictive value of this assay.
D000166:Acridines / Q000633:toxicity; D000375:Aging; D000818:Animals; D001711:Biotransformation; D007814:Larva / Q000187:drug effects; D009987:Orthoptera / Q000187:drug effects*; D013723:Teratogens / Q000378:metabolism; D014116:Toxicology / Q000379:methods*
D000166:Acridines; D013723:Teratogens