Effect of PRP on autologous rosette formation in mice.
It was demonstrated that PRP changes the number of autologous rosette forming cells (ARFC) among thymocytes and splenocytes in mice. Majority of ARFC was found in cortisone-resistant (CR) thymocytes and among glass adherent cells. Treatment of lymphocytes with PRP in vivo and in vitro causes significant reduction in the ARFC formation. It was revealed that PRP acts on two cell subpopulations belongings to both CS and CR thymocytes. PRP affecting cortisone-resistant glass adherent lymphocytes (CR GAL), accounting for the majority of ARFC within the thymus, causes a significant decrease of ARFC number, whereas, it elevates the number of ARFC in cortisonesensitive nonadherent lymphocytes (CS NAL). This phenomenon was the result of the parallel alteration in cortisone-sensitivity and the cell function by respective thymocyte subpopulations.
D000818:Animals; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051379:Mice; D010455:Peptides / Q000494:pharmacology*; D055232:Proline-Rich Protein Domains; D012397:Rosette Formation
D010455:Peptides