title: [Cutaneous necrosis of the breast: a complication of oral anticoagulant treatment].
abstract: Cutaneous necrosis of the breast is a rare complication of oral antivitamin K drugs. It occurs shortly after instituting therapy with well-limited, irreversible skin necrosis developing rapidly. The scar is superficial and only involves the subcutaneous tissue; early and extensive surgery does not therefore seem to be justified. Normal scarring is the eventual spontaneous outcome but this is always a long process. Several arguments are advanced in favour of a toxic effect of the drug itself on the vascular walls of the vessels in the dermis.
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000925:Anticoagulants / Q000008:administration & dosage / Q000009:adverse effects*; D001940:Breast / Q000473:pathology*; D005260:Female; D006801:Humans; D009336:Necrosis; D012867:Skin / Q000473:pathology*
chemical_list: D000925:Anticoagulants
vernacular_title: Nécrose cutanée du sein: complication du traitement par les anticoagulants oraux.