A novel human lymphokine that inhibits haematopoietic progenitor cell proliferation.
T lymphocytes in culture synthesize and secrete a variety of factors that activate and guide the differentiation, replication and maturation of haematopoietic cells in vitro. Malignant T-cell lines as well as T-cell hybridomas producing several of these factors have been established. We report here a factor produced by a human cell line that exerts a potent inhibitory effect on the growth of bone marrow progenitor cells. The properties of this factor, which we have termed colony-inhibiting lymphokine ( CIL ), differ from other inhibitors of haematopoietic progenitor cell proliferation, but resemble those of a T-cell-derived factor causally linked with some cases of severe aplastic anaemia in humans. Sensitivity of cells to this factor appears to correlate positively with expression of HLA-DR surface antigens.
D001853:Bone Marrow / Q000502:physiology; D002455:Cell Division; D002460:Cell Line; D002999:Clone Cells; D005260:Female; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D008222:Lymphokines / Q000302:isolation & purification / Q000502:physiology*; D008223:Lymphoma; D008970:Molecular Weight; D013601:T-Lymphocytes / Q000276:immunology*
D008222:Lymphokines