Pharmacological properties of 2-[4-(2-thiazolyloxy)-phenyl]-propionic acid (480156-S), a new non-steroidal antiinflammatory agent.
In terms of antiinflammatory activity in acute and chronic animal models, 2-[4-(2-thiazolyloxy)-phenyl]-propionic acid (480156-S) was more active than ibuprofen but inferior to indomethacin. The analgesic activities of 480156-S measured by the writhing method and the Randall & Selitto method were comparable or superior to those of indomethacin, diclofenac-Na and ketoprofen. 480156-S also had strong antagonistic action against bradykinin, markedly inhibiting all bradykinin-induced edema and pain reactions (tail licking in mice and flexor reflex of rabbit hind limb). On scald-induced pain in which bradykinin is greatly involved, 480156-S had an obviously stronger analgesic effect than any of the reference drugs. As for its effects on prostaglandin (PG), 480156-S weakly inhibited arachidonic acid-induced edema and pain reactions but also inhibited PGE2 synthesis of bovine vesicular gland microsomes.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000633:toxicity; D001169:Arthritis, Experimental / Q000188:drug therapy; D002351:Carrageenan / Q000037:antagonists & inhibitors; D004890:Erythema / Q000188:drug therapy; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010666:Phenylpropionates / Q000494:pharmacology*; D011453:Prostaglandins / Q000096:biosynthesis; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012018:Reflex / Q000187:drug effects; D013276:Stomach Ulcer / Q000139:chemically induced
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010666:Phenylpropionates; D011453:Prostaglandins; C041431:480156-S; D002351:Carrageenan