Effects of peroxisome proliferators on fatty acid-binding protein in rat liver.
The relationship between hepatic fatty acid-binding protein and peroxisomal beta-oxidation was studied. Rats were fed a diet containing p-chlorophenoxyisobutyric acid (clofibric acid), 2,2'-(decamethylenedithio)-diethanol (tiadenol), di-(2-ethylhexyl)-phthalate (DEHP), di-(2-ethylhexyl)-adipate (DEHA) and acetylsalicylic acid. On the administration of these peroxisome proliferators, both [1-14C]oleic acid-binding capacity and content of fatty acid-binding protein were increased, in association with an increase in peroxisomal beta-oxidation activity. The order of the increase in binding capacity and content of fatty acid-binding protein was tiadenol greater than DEHP greater than or equal to clofibric acid greater than DEHA = acetylsalicylic acid. The order of the increase in peroxisomal beta-oxidation activity in liver was tiadenol greater than clofibric acid greater than or equal to DEHP greater than DEHA = acetylsalicylic acid. Linear regression analysis between the binding capacity or content of fatty acid-binding protein and peroxisomal beta-oxidation activity was highly significant.
D000272:Adipates / Q000494:pharmacology; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001665:Binding Sites / Q000187:drug effects; D002352:Carrier Proteins / Q000302:isolation & purification / Q000378:metabolism*; D002846:Chromatography, Affinity; D002995:Clofibric Acid / Q000494:pharmacology; D003600:Cytosol / Q000378:metabolism; D004051:Diethylhexyl Phthalate; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005233:Fatty Alcohols / Q000494:pharmacology; D008099:Liver / Q000378:metabolism*; D008297:Male; D008830:Microbodies / Q000187:drug effects*; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains
D000272:Adipates; D002352:Carrier Proteins; C490174:Fabp7 protein, rat; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005233:Fatty Alcohols; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; C004568:tiadenol; C013966:dioctyl adipate; D002995:Clofibric Acid; D004051:Diethylhexyl Phthalate; D001241:Aspirin