[Gene mutations, chromosome aberrations and survival after the x-ray irradiation of a Chinese hamster cell culture protected by cysteamine].
The protective effect of cysteamine against 6-thioguanine-resistance (TCr) mutations, chromosome aberrations and inactivation caused by X-ray in cultured cells of Chinese hamster (clone 431) has been studied. The dose-effect curves have been obtained under irradiation condition without protector and with it. Dose-modifying factor of 2 was calculated for chromosome aberrations and cells inactivation and 2,8 for TCr mutations. It is supposed that the cysteamine acts on the general mechanisms involved in damages realization which results in gene mutations, chromosome aberrations and cell inactivation.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002999:Clone Cells / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D003543:Cysteamine / Q000494:pharmacology*; D004307:Dose-Response Relationship, Radiation; D005796:Genes / Q000187:drug effects / Q000528:radiation effects*; D009154:Mutation
D003543:Cysteamine
Gennye mutatsii, aberratsii khromosom i vyzhivaemost' posle rentgenovskogo oblucheniia kul'tury kletok kitaĭskogo khomiachka v usloviiakh zashchity tsisteaminom.