Effects of T-2 mycotoxin on bovine serum proteins.
Mycotoxin T-2 (0.5 mg/kg of body weight) was administered orally to mixed-breed beef calves. Serum protein fractions, immunoglobulin (Ig) G, IgM, and several complement protein concentrations were studied in control and toxin-treated calves. Total protein, albumin, and globulin concentrations all decreased in toxin-treated calves as compared with that in controls. Similarly, the concentrations of alpha-, beta 1-, and beta 2-globulin fractions were reduced in the toxin-treated calves more than those in controls. The IgG and IgM values were lower in toxin-treated calves than those in the controls. Complement proteins Bbov (of the alternate pathway) and the 3rd component of complement were lower in the toxin-treated calves. The fragment of Bbov activation, B gamma 2, was increased after toxin treatment, indicating that activation of the alternate complement pathway was responsible for at least some of the reduction of the 3rd component of complement.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002417:Cattle; D003165:Complement System Proteins / Q000378:metabolism; D007136:Immunoglobulins / Q000378:metabolism; D009183:Mycotoxins / Q000494:pharmacology*; D012709:Serum Albumin / Q000378:metabolism
D001798:Blood Proteins; D007136:Immunoglobulins; D009183:Mycotoxins; D012709:Serum Albumin; D003165:Complement System Proteins