The effect of some contrast agents in the lung: an experimental study in the rat and dog.
Radiographic and histologic studies were carried out in rats and dogs after the instillation of Barosperse, Hypaque-35%, metrizamide, MP10013 (a nonionic iodine-containing agent), and isotonic saline into the lungs of these animals. In addition, blood gases were examined using these agents in dogs. Given aspiration of larger quantities of the contrast agents, the nonionic iodine-containing agents (metrizamide and MP10013) were better tolerated and evoked less pulmonary response than either Hypaque-35% or Barosperse.
D000818:Animals; D001466:Barium Sulfate / Q000633:toxicity; D003287:Contrast Media / Q000633:toxicity*; D003973:Diatrizoate / Q000633:toxicity; D004064:Digestive System / Q000000981:diagnostic imaging; D004285:Dogs; D007472:Iohexol / Q000031:analogs & derivatives*; D008168:Lung / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008793:Metrizamide / Q000633:toxicity; D010100:Oxygen / Q000097:blood; D011859:Radiography; D051381:Rats; D011919:Rats, Inbred Strains; D014283:Triiodobenzoic Acids / Q000633:toxicity
D003287:Contrast Media; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; D001466:Barium Sulfate; D007472:Iohexol; C036778:iogulamide; D008793:Metrizamide; D010100:Oxygen