Effect of an homo-aza-steroidal ester on estrogen receptor.
A new modified steroid esterified with the cytotoxic moiety, p-[N,N-bis(2-chloroethyl)amino]phenyl-acetic acid, has been synthesized and tested for interaction with estrogen receptor and cytotoxic activity on the MCF-7 cell line.
D000230:Adenocarcinoma / Q000378:metabolism; D000970:Antineoplastic Agents; D001378:Azasteroids / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000378:metabolism; D002460:Cell Line; D004273:DNA, Neoplasm / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D005260:Female; D006801:Humans; D007700:Kinetics; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D011960:Receptors, Estrogen / Q000187:drug effects*; D013260:Steroids, Heterocyclic / Q000494:pharmacology*
D000970:Antineoplastic Agents; D001378:Azasteroids; D004273:DNA, Neoplasm; D009588:Nitrogen Mustard Compounds; D011960:Receptors, Estrogen; D013260:Steroids, Heterocyclic; D004958:Estradiol; C039219:17-aza-homo-delta (1,3,5(10)) estratrien-3-ol-17-one-4-N,N-bis(2-chloroethyl)aminophenylacetate