Metabolism of the anticancer agent 1-(4-acetylphenyl)-3,3-dimethyltriazene.
High pressure liquid chromatography was used in combination with mass spectrometry to confirm that the main products of in vitro metabolism of 1-(4-acetylphenyl)-3,3-dimethyltriazene are 1-(4-acetylphenyl-3-methyltriazene and 4-aminoacetophenone. In addition a novel metabolite, 1-[4-(1-hydroxyethyl)-phenyl]-3,3-dimethyltriazene, possessing antitumour activity similar to the parent drug, was identified.
D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism*; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005260:Female; D008099:Liver / Q000201:enzymology; D051379:Mice; D008810:Mice, Inbred C57BL; D014226:Triazenes / Q000378:metabolism* / Q000494:pharmacology
D000970:Antineoplastic Agents; D014226:Triazenes; C034951:1-(4-acetyphenyl)-3,3-dimethyltriazene