B-cell function in vitro during rubella infection.
B-cell function in vitro was studied in patients with natural rubella virus infection. Lymphocyte responses to mitogens in a blast transformation test were decreased at the onset of the rash. Spontaneous immunoglobulin production by peripheral blood lymphocytes was increased during the acute phase of illness. In regulatory T-cell subpopulations, increased proportions of cells with suppressor/cytotoxic phenotypes and decreased proportions of cells with helper/inducer phenotypes were detected simultaneously with the increased spontaneous immunoglobulin production. All parameters studied were recovered during the convalescent phase.
D000293:Adolescent; D000328:Adult; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008213:Lymphocyte Activation; D008297:Male; D012409:Rubella / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology
D007070:Immunoglobulin A; D007074:Immunoglobulin G