[Simulation of the effect of biologically active substances in models].
The results obtained from historadioautographic examinations of the epithelium of the small intestine of rats under the action of procaine served as a basis for examining the proliferative system by using a model. The following results have been obtained through computerized simulation: 1. The maximum life-time of the enterocytes is prolonged at constant villous height, which means that on average the villous is studded with older cells than normally. 2. The prolonged time of generation of the proliferatively active cryptic epithelial cells calls for a pronounced reduction in the pool of reserve cells (cells in the G0 phase, non-growth fraction), i.e. for their activation in order to realize the system characteristics described under 1. 3. The condition of the system induced by procaine may be compared, in its changed tendency, neither to the changing tendencies during aging nor to those under pathological conditions. It is rather a new condition that is being produced and which is characterized, inter alia, by the characteristics described under 1 and 2.
D000375:Aging; D000818:Animals; D001345:Autoradiography; D002455:Cell Division / Q000187:drug effects; D004848:Epithelium; D007421:Intestine, Small / Q000187:drug effects / Q000502:physiology*; D008954:Models, Biological; D011343:Procaine / Q000494:pharmacology*; D051381:Rats
D011343:Procaine
Zur Simulation der Wirkung von biologisch aktiven Substanzen im Modell.