Vitamin D levels and trabecular bone remodelling before and after surgery for medullary thyroid carcinoma.
We previously reported increased mean serum 1,25-dihydroxyvitamin D (1,25-(OH)2D) and increased trabecular bone remodelling in patients with medullary thyroid carcinoma (MCT) and hypercalcitoninaemia. In the present paper we report that serum 1,25-(OH)2D and trabecular bone remodelling decreased following surgical cure for MCT and hypercalcitoninaemia in 4 patients despite no detectable post-surgical hypoparathyroidism or hypothyroidism. The results obtained in the present small number of patients suggest that the altered vitamin D metabolism and trabecular bone remodelling in patients with MCT is caused by the hypercalcitoninaemia.
D015650:24,25-Dihydroxyvitamin D 3; D000328:Adult; D000368:Aged; D001842:Bone and Bones / Q000378:metabolism* / Q000473:pathology; D002116:Calcitonin / Q000097:blood*; D002117:Calcitriol / Q000097:blood*; D002277:Carcinoma / Q000097:blood* / Q000601:surgery; D004100:Dihydroxycholecalciferols / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood; D013964:Thyroid Neoplasms / Q000097:blood* / Q000601:surgery; D014807:Vitamin D / Q000097:blood*
D004100:Dihydroxycholecalciferols; D010281:Parathyroid Hormone; D013963:Thyroid Hormones; D014807:Vitamin D; D015650:24,25-Dihydroxyvitamin D 3; D002116:Calcitonin; D002117:Calcitriol