Sensitive flame-photometric-detector analysis of thiodiglycolic acid in urine as a biological monitor of vinyl chloride.
A simple and selective method to detect thiodiglycolic acid (TdGA) in urine by flame-photometric-detector (FPD) of gas chromatograph (GC) is described. The detection limit of this method is less than 1 ng without disturbances. Urine from 64 subjects exposed to different air concentration of vinyl chloride (VCM) from 0.3 ppm to more than 100 ppm in three groups and 78 subjects was detected in this way. A comparison of the results of these groups shows significant differences between the control and two exposed groups.
D000395:Air Pollutants, Occupational / Q000633:toxicity*; D006801:Humans; D010783:Photometry; D013864:Thioglycolates / Q000652:urine*; D014752:Vinyl Chloride / Q000633:toxicity*; D014753:Vinyl Compounds / Q000633:toxicity*
D000395:Air Pollutants, Occupational; D013864:Thioglycolates; D014753:Vinyl Compounds; C010518:thiodiacetic acid; D014752:Vinyl Chloride