Malignant hypertension and HLA antigens.
Thirty-two patients with malignant hypertension and terminal uremia and a group of 1263 healthy blood donors were studied regarding the incidence of different HLA antigens. HLA-Bw35; Cw4 antigens were found to be significantly more frequent in the group of patients with malignant hypertension than in the group of healthy individuals. The frequency of HLA-Bw35 in a group of 60 non-uremic patients with biopsy-proven glomerulonephritis and without malignant hypertension was also studied and found equal to the group of healthy blood donors. There was no overrepresentation of IgA nephritis among the HLA-Bw35 positive patients with glomerulonephritis, but advanced vascular lesions were more common among these than among patients with other HLA antigens.
D005921:Glomerulonephritis / Q000235:genetics / Q000276:immunology; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D006801:Humans; D006974:Hypertension, Malignant / Q000235:genetics / Q000276:immunology*
D006680:HLA Antigens