Inhibition of wound healing by topical steroids.
A new animal model was used to study the effect of topical agents on wound healing. A weak- (hydrocortisone cream 1%) and medium-strength (fluocinolone acetonide ointment 0.025%) steroid and their vehicles were applied to full-thickness skin wounds placed on the backs of female Syrian hamsters. Wound healing was significantly retarded by both steroids when compared to their vehicles. Fluocinolone had a greater inhibitory effect than hydrocortisone.
D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D006224:Cricetinae; D003864:Depression, Chemical; D005260:Female; D005446:Fluocinolone Acetonide / Q000008:administration & dosage / Q000494:pharmacology*; D006854:Hydrocortisone; D008647:Mesocricetus; D009824:Ointments; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
D000893:Anti-Inflammatory Agents; D009824:Ointments; D005446:Fluocinolone Acetonide; D006854:Hydrocortisone