Neurotensin facilitates dopamine release in vitro from rat striatal slices.
Neurotensin, (0.1-10 microM) stimulated the release of [3H]dopamine from rat striatal slices in a calcium-dependent manner, and potentiated the K+-evoked release of [3H]dopamine and endogenous dopamine. This effect was dose-dependent, (1 nM-1 microM) with an EC50 of approximately 10 nM, and was mediated by means of a receptor of similar structure-activity profile to those described in other tissues.
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D008297:Male; D009496:Neurotensin / Q000008:administration & dosage / Q000494:pharmacology*; D011188:Potassium / Q000008:administration & dosage; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
D009496:Neurotensin; D011188:Potassium; D004298:Dopamine