Morphology of human T lymphocyte clones.
Six human T lymphocyte clones, characterized as to cytolytic activities and several surface markers, were investigated for possible morphologic correlates of function. Cytotoxic T lymphocyte clones and natural killer-like clones had basically similar morphology, but cytotoxic T lymphocytes tended to cluster in groups and had many more lipid bodies, whereas natural killer-like cells had fewer intercellular contacts and had more and larger electron-dense bodies. Dense bodies were also quite prominent in noncytotoxic clones. The latter were distinctive in having a minority of very large cells (10 to 16 microns) with many microvilli, scattered among the majority of 5- to 8-microns diameter cells.
D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface; D002999:Clone Cells / Q000648:ultrastructure*; D006801:Humans; D007694:Killer Cells, Natural; D008854:Microscopy, Electron; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000648:ultrastructure*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface