Phosphorylation events during Müllerian duct regression.
Regression of the fetal rat Müllerian duct in vitro was stimulated by sodium fluoride in the absence of Müllerian inhibiting substance. The action of Müllerian inhibiting substance was inhibited by sodium vanadate, adenosine 5'-triphosphate, and several related nucleotides in the presence of manganese ions. Epidermal growth factor specifically inhibited the substance, but only with manganese ions present. Insulin, platelet-derived growth factor, and nerve growth factor had no effect. These results suggest that dephosphorylation of membrane proteins mediates the action of Müllerian inhibiting substance.
D000818:Animals; D054304:Anti-Mullerian Hormone; D002413:Cations, Divalent; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004815:Epidermal Growth Factor / Q000494:pharmacology; D005260:Female; D006023:Glycoproteins; D006131:Growth Inhibitors; D007700:Kinetics; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism; D009095:Mullerian Ducts / Q000187:drug effects / Q000502:physiology*; D010766:Phosphorylation; D011247:Pregnancy; D051381:Rats; D012969:Sodium Fluoride / Q000494:pharmacology; D013735:Testicular Hormones / Q000502:physiology*; D014638:Vanadates; D014639:Vanadium / Q000494:pharmacology
D002413:Cations, Divalent; D006023:Glycoproteins; D006131:Growth Inhibitors; D008565:Membrane Proteins; D013735:Testicular Hormones; D014639:Vanadium; D014638:Vanadates; D004815:Epidermal Growth Factor; D054304:Anti-Mullerian Hormone; D012969:Sodium Fluoride; D004121:Dimethyl Sulfoxide