The nature of hairy cells - a study with a panel of monoclonal antibodies.
In all 11 patients with hairy-cell leukaemia (HCL) tested, a high percentage of peripheral blood and splenic (3 cases) hairy cells (HCs) reacted with 2 B-cell-specific monoclonal antibodies (FMC1 and FMC7), but failed to stain with 5 monocyte/macrophage-specific (FMC17, UCHM1, SM1, SMø and OKM1) and with 4 T-cell-specific antibodies (UCHT1, Leu1, 2a and 3a). The data provide further evidence in support of the B-cell nature of the HCs of HCL.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000276:immunology; D002471:Cell Transformation, Neoplastic / Q000276:immunology*; D006801:Humans; D007943:Leukemia, Hairy Cell / Q000276:immunology*; D051379:Mice; D013154:Spleen / Q000276:immunology
D000911:Antibodies, Monoclonal