Reduced oxygen enhancement of the radiosensitivity of glutathione-deficient fibroblasts.
Following the demonstration of the radioprotective role of artificial aminothiols, the question logically arose concerning the role of aminothiols present naturally in cells: non-protein bound sulfhydryls (NPSH), especially glutathione (GSH). The latter is the most abundant NPSH and would be a likely candidate for a radioprotector.
D000592:Amino Acid Metabolism, Inborn Errors / Q000378:metabolism; D002470:Cell Survival; D002478:Cells, Cultured; D004247:DNA / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts; D005978:Glutathione / Q000378:metabolism*; D005981:Glutathione Synthase / Q000172:deficiency*; D006801:Humans; D008920:Misonidazole / Q000494:pharmacology; D010100:Oxygen; D010453:Peptide Synthases / Q000172:deficiency*; D011836:Radiation Tolerance
D008920:Misonidazole; D004247:DNA; D010453:Peptide Synthases; D005981:Glutathione Synthase; D005978:Glutathione; D010100:Oxygen