Synthesis and quality control testing of 32P labeled ion exchange resin microspheres for radiation therapy of hepatic neoplasms.
Commercial cation exchange resin beads (200--400 mesh) are separated into narrow particle size ranges by sieving and differential sedimentation. These microspheres are converted into the chromic form by reaction with Cr(NO2)3, labeled with 20 mCi 32P phosphate by exchange at pH 2--4, and converted to a stable product at pH 9. Chemical stability ahd biological behavior of these microspheres suspended in physiological saline is measured before administration through a hepatic artery catheter for radiation therapy of the liver and hepatic neoplasms.
D002404:Catheterization; D006499:Hepatic Artery; D006801:Humans; D007475:Ion Exchange Resins; D007553:Isotope Labeling / Q000379:methods; D008113:Liver Neoplasms / Q000532:radiotherapy*; D008863:Microspheres; D010761:Phosphorus Radioisotopes / Q000008:administration & dosage*; D011786:Quality Control
D007475:Ion Exchange Resins; D010761:Phosphorus Radioisotopes