Ability of the CRF immunoreactive neurons of the paraventricular nucleus to produce a vasopressin-like material. Immunohistochemical demonstration in adrenalectomized guinea pigs and rats.
In the paraventricular nucleus of normal or adrenalectomized colchicine-treated guinea pigs and rats, corticotropin-releasing factor (CRF), vasopressin (VP) and oxytocin (OX) immunoreactivities were compared. In the control animals, respective stainings for these three peptides are distinct. Adrenalectomy resulted in the appearance of a VP-like staining in most of the CRF-immunoreactive neurons whereas OX staining remained distinct. It is suggested that the CRF/VP coexistence reflects the synergistic role of the two peptides.
D000315:Adrenalectomy; D000818:Animals; D003078:Colchicine / Q000494:pharmacology; D003346:Corticotropin-Releasing Hormone / Q000032:analysis* / Q000276:immunology; D006168:Guinea Pigs; D006651:Histocytochemistry; D008297:Male; D009474:Neurons / Q000032:analysis / Q000276:immunology; D010121:Oxytocin / Q000032:analysis / Q000276:immunology; D010286:Paraventricular Hypothalamic Nucleus / Q000032:analysis* / Q000276:immunology; D051381:Rats; D014667:Vasopressins / Q000032:analysis* / Q000276:immunology
D014667:Vasopressins; D010121:Oxytocin; D003346:Corticotropin-Releasing Hormone; D003078:Colchicine