title: Plasma clearance of 99mTc-N/2,4-dimethyl-acetanilido/iminodiacetate complex as a measure of parenchymal liver damage.
abstract: Fifty-two patients were studied with various diseases affecting liver parenchyma. Any disorders of bile transport were excluded on the basis of dynamic liver scintigraphy using intravenously injected N/2,4-dimethyl acetanilido/iminodiacetate 99mTc complex (HEPIDA). The activity concentration of 99mTc-HEPIDA in plasma was measured from 5 through 60 min post injection. Clearance of the substance (ClB) was calculated from blood plasma disappearance curves and compared with results of 13 laboratory tests used conventionally for assessment of damage of the liver and its functional capacity; age and body weight was also included in the analysis. Statistical relations were studied using linear regression analysis of two variables, multiple regression analysis as well as multidimensional analysis of variance. It was demonstrated that 99mTc-HEPIDA clearance is a simple, accurate and repeatable measure of liver parenchyma damage. In males, values of ClB above 245 ml. min-1/1.73 m2 exclude hepatic damage with high probability; values below 195 ml.min-1/1.73 m2 indicate evident impairment of liver parenchyma function.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury; D006801:Humans; D007098:Imino Acids / Q000097:blood; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging; D008107:Liver Diseases / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D013667:Technetium / Q000097:blood; D019780:Technetium Tc 99m Lidofenin; D014752:Vinyl Chloride / Q000506:poisoning
chemical_list: D007098:Imino Acids; D019780:Technetium Tc 99m Lidofenin; D013667:Technetium; D014752:Vinyl Chloride