title: Regional blood flow in ethylnitrosourea-induced brain tumors.
abstract: Regional blood flow was measured in experimental brain tumors using iodoantipyrine labeled with carbon 14 and quantitative autoradiography. A total of fifteen oligodendrogliomas, sixteen mixed gliomas, one astrocytoma, one ependymoma, and three malignant schwannomas were studied in 9 rats. The mean tumor blood flows for all glioma classifications were similar, averaging 45 +/- 3 (standard error of the mean) ml . hg-1 . min-1. Flow was fairly uniform within individual oligodendrogliomas and there was no apparent correlation between blood flow and tumor size or location. The mixed gliomas were larger than the oligodendrogliomas and had a wider range of blood flow. Small focal areas of necrosis were observed in 7 mixed gliomas, and low flows were usually measured in these regions; these flows were not always the lowest regional values measured within the mixed gliomas or total group of tumors, however. Small tumor regions with increased vascularity, frequently with endothelial cell proliferation, were observed in oligodendrogliomas and to a greater extent in mixed gliomas; these regions were correlated with small elevations in blood flow (10 to 15 ml . hg-1 . min-1) in comparison with surrounding tumor tissue. Brain adjacent to tumor usually had higher blood flows than that in tumor periphery. Hemispheric differences in blood flow related to the site of primary tumor growth were not observed.
mesh_terms: D000818:Animals; D001254:Astrocytoma / Q000098:blood supply; D001783:Blood Flow Velocity; D001932:Brain Neoplasms / Q000098:blood supply / Q000139:chemically induced*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004806:Ependymoma / Q000098:blood supply; D005038:Ethylnitrosourea / Q000633:toxicity*; D005260:Female; D005910:Glioma / Q000098:blood supply / Q000139:chemically induced; D008297:Male; D009374:Neoplasms, Experimental / Q000098:blood supply / Q000139:chemically induced; D009442:Neurilemmoma / Q000098:blood supply; D009607:Nitrosourea Compounds / Q000633:toxicity*; D009837:Oligodendroglioma / Q000098:blood supply / Q000139:chemically induced; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow / Q000187:drug effects
chemical_list: D009607:Nitrosourea Compounds; D005038:Ethylnitrosourea