[Bone marrow capacity and reaction].
The formation of the blood cells leads via proliferation, differentiation and maturation processes, in which cases the bone marrow capacity expresses the functional capacity of this comprehensive system of cell renovation. Nowadays clues to the quantitative behaviour of proliferation of the various compartments (stem cell compartment, indicator cell compartment and morphologically characterizable cell compartment) are already existing also for man, in which cases various proliferation-kinetic tests give adequate informations. Via a quantitative determination of the granulocytes of the bone marrow an estimation of the postmitotic bone marrow storage of the granulocytopoiesis is at present possible. The responsiveness of the neutrophil granulocytes after stimulation (glucocorticoids, endotoxin) may be used in the clinic as bone marrow functional test with restricted statement. The diagnostic possibilities of the agar-colony-technique for the judgment of the bone marrow capacity are represented on the basis of an instance.
D000328:Adult; D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001853:Bone Marrow / Q000502:physiology*; D002455:Cell Division / Q000187:drug effects; D003114:Colony-Forming Units Assay; D004731:Endotoxins / Q000494:pharmacology; D006046:Gold / Q000627:therapeutic use; D006098:Granulocytes / Q000187:drug effects; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D007962:Leukocytes / Q000187:drug effects; D051379:Mice; D008875:Middle Aged
D004731:Endotoxins; D006046:Gold
Knochenmarkkapazität und -reaktion.