title: Intravenous dehydrocholate tolerance test in patients with liver disease.
abstract: The disappearance of intravenously administered dehydrocholate was studied in 13 healthy subjects and 23 patients with chronic liver disease. Serum dehydrocholate was determined by the enzymatic method using 3 alpha-hydroxysteroid dehydrogenase. Following the loading dose of dehydrocholate, serum dehydrocholate and 3 alpha-hydroxy bile acid were assayed at five minute intervals for 15 minutes. During this 15 minute period, dehydrocholate decreased and 3 alpha-hydroxy bile acid increased. The disappearance of the dehydrocholate was delayed in patients with chronic liver disease, and the 5-minute retention value was significantly high in cirrhosis patients.
mesh_terms: D001647:Bile Acids and Salts / Q000097:blood; D003685:Dehydrocholic Acid / Q000008:administration & dosage / Q000097:blood; D006207:Half-Life; D006521:Hepatitis, Chronic / Q000175:diagnosis; D006801:Humans; D007275:Injections, Intravenous; D008103:Liver Cirrhosis / Q000175:diagnosis; D008107:Liver Diseases / Q000097:blood / Q000175:diagnosis*; D013997:Time Factors
chemical_list: D001647:Bile Acids and Salts; D003685:Dehydrocholic Acid