title: [Immunological effectiveness of the combined vaccination of donors with inactivated chromatographic influenza vaccine and adsorbed staphylococcal anatoxin].
abstract: The influence of combined immunization with inactivated chromatographic vaccine and adsorbed staphylococcal toxoid on the activity of the immune system of volunteer donors has been studied. With the T- to B-cell ratio in the peripheral blood remaining stable, the third injection of staphylococcal toxoid induces a certain suppression of the capacity of lymphocytes for blast transformation in the presence of mitogen and specific antigens. The intensity of the accumulation of anti-alpha-staphylolysin is subject to considerable individual variations and depends on its level prior to immunization. The level of influenza antihemagglutinins remains most stable when the interval between the injection of inactivated chromatographic influenza vaccine and the beginning of immunization with adsorbed staphylococcal toxoid is 3-6 months.
mesh_terms: D000327:Adsorption; D000888:Antibodies, Anti-Idiotypic / Q000032:analysis; D000907:Antibodies, Bacterial / Q000032:analysis; D000914:Antibodies, Viral / Q000032:analysis; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000276:immunology; D004341:Drug Evaluation; D006460:Hemolysin Proteins / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007252:Influenza Vaccines / Q000008:administration & dosage* / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D013208:Staphylococcal Toxoid / Q000008:administration & dosage* / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D013997:Time Factors; D014613:Vaccines, Attenuated / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000907:Antibodies, Bacterial; D000914:Antibodies, Viral; D006460:Hemolysin Proteins; D007136:Immunoglobulins; D007252:Influenza Vaccines; D013208:Staphylococcal Toxoid; D014613:Vaccines, Attenuated; C006603:antistaphylolysin
vernacular_title: Immunologicheskaia éffektivnost' sochetannoĭ vaktsinatsii donorov inaktivirovannoĭ khromatograficheskoĭ grippoznoĭ vaktsinoĭ i adsorbirovannym stafilokokkovym anatoksinom.