Metabolic and endocrine basis of the growth retardation in sickle cell disease.
Preliminary findings related to possible mechanisms causing somato-sexual growth retardation in sickle-cell disease are reported. The studies indicate that important factors are: a) negative nitrogen balance which is attributable to either poor intestinal supply of nitrogen and/or impaired utilization of nitrogen; b) inadequate circulating testosterone and human growth hormone especially during adolescence; c) increased basal metabolic rate, in the presence of normal thyroid function. Further investigation is required to elucidate the relative importance of these factors.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000755:Anemia, Sickle Cell / Q000150:complications* / Q000378:metabolism; D006130:Growth Disorders / Q000209:etiology* / Q000378:metabolism; D013006:Growth Hormone / Q000097:blood; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D013739:Testosterone / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood; D014994:Xylose / Q000378:metabolism
D006728:Hormones; D013963:Thyroid Hormones; D013739:Testosterone; D013006:Growth Hormone; D014994:Xylose; D009584:Nitrogen