title: [Bovicystan treatment of subclinical ketosis in cows].
abstract: Experiments with normal animals (10 sheep and 15 cows) revealed that the intravenous injection of bovicystan led to a considerable and dependable rise of the blood sugar for 2 to 36 hours the peak being at the 6th hour. The treatment of 95 freshly calved cows on 8 farms with signs of subclinical ketosis (ketonemia 22.4 +/- 1.9 mg%, ketonuria up to dilution of 1:2-1:16 and hypoglycemia 26.7 +/- 2.6 mg%) resulted in a 92.6 per cent total curative effect, consisting in the full inhibition of ketonuria, drop of the ketone bodies in the blood up to 16.5 +/- 1.2 mg%, on an average, and rise of the blood sugar up to 47.7 +/- 1.2 mg%, on an average. In 27.4 per cent of the treated cows ketonuria disappeared after the first injection, in 50.5 per cent - after the second one, and in 14.7 per cent only did ketonuria faded after the third injection of the preparation within a period of 24 hours. At the 48th hour following the last introduction of bovicystan there was an increase in the blood serum level of carotene and lactose, and a decrease in the level of inorganic phosphorus. One to three weeks after treatment with bovicystan in some 27.6 to 33.0 per cent of the cows on 2 of the farms signs of subclinical ketosis reappeared.
mesh_terms: D000138:Acidosis / Q000662:veterinary*; D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage*; D001786:Blood Glucose / Q000032:analysis; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D003543:Cysteamine / Q000008:administration & dosage*; D003907:Dexamethasone / Q000008:administration & dosage*; D004338:Drug Combinations; D004341:Drug Evaluation / Q000662:veterinary; D004353:Drug Evaluation, Preclinical / Q000662:veterinary; D005260:Female; D007662:Ketosis / Q000188:drug therapy / Q000662:veterinary*; D012756:Sheep; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D004338:Drug Combinations; C039186:ascorbic acid, cysteamine, dexamethasone drug combination; D003543:Cysteamine; D003907:Dexamethasone; D001205:Ascorbic Acid
vernacular_title: Lekuvane na subklinichnata ketoza pri kravi s bovitsistan.