Antimicrobial therapy in patients with impaired renal function.
In order to formulate a thoughtful and rational approach to drug dosing in renal failure, the nephrologist must consider several features that influence drug disposition in uremia. Drug bioavailability is generally adversely influenced in patients with renal disease. Drug distribution is frequently altered to an unpredictable degree. Drug protein binding is affected not only by changes in the amount of circulating binding protein but also by the accumulation of endogenous toxins. Renal failure frequently affects drug biotransformation. Drug-dosing tables and nomograms are important; however, they are not a substitute for an encompassing clinical approach and sound clinical judgment.
D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000627:therapeutic use; D001682:Biological Availability; D006801:Humans; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects
D000900:Anti-Bacterial Agents