title: On the site of pentylenetetrazol-induced enhancement of auditory responses of the reticular formation: localized cooling and electrical stimulation studies.
abstract: Pentylenetetrazol (PTZ), administered systemically, enhanced the auditory responses of neurons of the mesencephalic reticular formation (MRF). Responses evoked in the mesencephalic reticular formation by electrical stimuli in several primary auditory nuclei (cochlear nucleus, superior olivary complex and lateral lemniscus, but not inferior colliculus) were also enhanced by pentylenetetrazol in the majority of cases. Bilateral cryoprobe cooling in the lateral lemniscal tract substantially reduced the auditory-evoked field potentials (EPs) in the mesencephalic reticular formation before and after administration of pentylenetetrazol. Cooling in the inferior colliculus (IC) produced a small reduction in auditory-evoked field potentials in the mesencephalic reticular formation before drug but a more substantial degree of reduction after administration of pentylenetetrazol. A relatively small degree of pentylenetetrazol-induced enhancement of the response was seen in neurons of the inferior colliculus (158% of control) as compared to that of neurons in the mesencephalic reticular formation (410%). These findings would be consistent with the reported ability of pentylenetetrazol to block presynaptic inhibition if the input from the inferior colliculus to the mesencephalic reticular formation has inhibitory as well as excitatory components. These data along with the present authors' recent finding of enhancement of response with microapplication of convulsants strongly suggest that enhancement of responses of neurons of the mesencephalic reticular formation, induced by systemically administered convulsants such as pentylenetetrazol is exerted, to a large extent, by direct actions on synaptic elements of the reticular formation.
mesh_terms: D000818:Animals; D001306:Auditory Pathways / Q000187:drug effects; D001307:Auditory Perception / Q000187:drug effects; D001933:Brain Stem / Q000187:drug effects; D002415:Cats; D003056:Cochlear Nerve / Q000187:drug effects*; D004558:Electric Stimulation; D005072:Evoked Potentials, Auditory / Q000187:drug effects; D005260:Female; D005829:Geniculate Bodies / Q000187:drug effects; D007245:Inferior Colliculi / Q000187:drug effects; D008297:Male; D008636:Mesencephalon / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D010433:Pentylenetetrazole / Q000494:pharmacology*; D012154:Reticular Formation / Q000187:drug effects*
chemical_list: D010433:Pentylenetetrazole