[Action of chloditane on the phospholipid composition of the adrenals in dogs].
The effect of chloditane/mitotan; 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2,2-dichloroethane; o,p'-DDD/ on phospholipid composition of dog adrenal glands was examined. Feeding of mongrel dogs with the adrenocorticolytic drug chloditane increased the content of phosphatidylserine, phosphatidylinositol and sphingomyelin. Chloditane lowered the content of diphosphatidylglycerin and lisophosphatidylethanolamine in dog adrenal cortex. The drug did not produce any effect on the content of major phosphatides--phosphatidylethanolamine and phosphatidylcholine or on the fatty acid content of phosphatidylcholine.
D000302:Adrenal Cortex / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D004285:Dogs; D005227:Fatty Acids / Q000032:analysis; D006801:Humans; D008297:Male; D008939:Mitotane / Q000494:pharmacology*; D010743:Phospholipids / Q000032:analysis / Q000378:metabolism*; D013997:Time Factors
D005227:Fatty Acids; D010743:Phospholipids; D008939:Mitotane
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