Protection against X-irradiation by some orally administered compounds.
A number of compounds were studied that protected mice against LD50/30 after X-irradiation. For three compounds (WR 109342, WR 158490 and WR 159243) dose reduction factors between 1.7 and 1.8 were obtained after oral administration. Blood taken from mice that had been treated with these protective compounds provided virtually no protection of HeLa cells in vitro, whereas when blood from cysteamine treated mice was tested in vitro, protection could be demonstrated. This may indicate different mechanisms of action.
D000218:Adamantane / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000032:analysis* / Q000633:toxicity; D000284:Administration, Oral; D000578:Amidines / Q000008:administration & dosage / Q000633:toxicity; D000818:Animals; D008297:Male; D051379:Mice; D011837:Radiation-Protective Agents / Q000008:administration & dosage* / Q000633:toxicity; D013844:Thiazoles / Q000008:administration & dosage / Q000633:toxicity
D000578:Amidines; D011837:Radiation-Protective Agents; D013844:Thiazoles; C035283:WR 109342; D000218:Adamantane