title: The 24-hour control of blood pressure in hypertension of chronic renal disease with mepindolol.
abstract: The efficacy of mepindolol in the control of blood pressure during 24 hours was investigated in nine patients with hypertension accompanying chronic renal disease. The patients were classified into three groups having glomerular filtration rates of 50% to 55%, 30% to 35%, and 10% to 15%. The daily dosage of mepindolol was 5 mg for patients with glomerular filtration rates 30% and higher and 2.5 and 1.25 mg for patients with more advanced renal failure. The control of blood pressure was adequate in patients treated with 5 mg. In those with advanced renal failure, 2.5 mg was adequate to control blood pressure, but 1.25 mg was an inadequate dosage. These results point to the efficacy of mepindolol in the treatment of hypertension of chronic renal disease. Moreover, the dosage of the beta-blocker can be reduced by half the recommended dosage when advanced renal failure is present.
mesh_terms: D000328:Adult; D002908:Chronic Disease; D004305:Dose-Response Relationship, Drug; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy*; D006801:Humans; D006977:Hypertension, Renal / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial; D010869:Pindolol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013997:Time Factors
chemical_list: C015340:mepindolol; D010869:Pindolol