Cetaben versus clofibrate: comparison of toxicity and peroxisome proliferation in rats.
Cetaben and clofibrate were each administered to groups of 6 rats (3 male and 3 female) by gavage at dosages of 50 mg/kg per day and 200 mg/kg per day for 2 weeks. Cetaben caused 1 death at 200 mg/kg per day and decreases in body weight gain and food consumption at 50 mg/kg per day or more. There were no effects on body weight or food consumption in the clofibrate-treated groups. At 200 mg/kg per day cetaben and clofibrate induced comparable increases in liver weight and in numbers of liver peroxisomes while cetaben caused increases in liver catalase activity as well.
D010129:4-Aminobenzoic Acid / Q000633:toxicity*; D062365:Aminobenzoates / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002374:Catalase / Q000378:metabolism; D002994:Clofibrate / Q000633:toxicity*; D005260:Female; D006529:Hepatomegaly / Q000139:chemically induced* / Q000473:pathology; D000960:Hypolipidemic Agents / Q000633:toxicity*; D008074:Lipoproteins / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure; D008297:Male; D008830:Microbodies / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D062366:para-Aminobenzoates
D062365:Aminobenzoates; D000960:Hypolipidemic Agents; D008074:Lipoproteins; D062366:para-Aminobenzoates; C018246:cetaben; D002374:Catalase; D002994:Clofibrate; D010129:4-Aminobenzoic Acid