Hemodynamic effects of lactated Ringer's solution on hemorrhagic shock during exposure to hyperbaric air and hyperbaric hyperoxia.
Three groups of six dogs each were instrumented with an electromagnetic flow-meter around the pulmonary artery, and indwelling silastic cannulas in the pulmonary artery, the left ventricle, the ascending aorta and the right atrium. After allowing 5-7 d for recovery the dogs were studied under normobaric conditions, breathing air, at 2.8 atmospheres absolute (ATA) breathing 100% oxygen (PO2 approximately equal to 2128 mm Hg) and at 6 ATA breathing air (PO2 approximately equal to 960 mm Hg). Baseline recordings were made at 1 ATA and repeated after arrival at depth. The dogs were hemorrhaged until the mean aortic pressure fell to 40 mm Hg. Mean aortic pressure was maintained between 40-50 mm Hg for 30 min. Enough lactated Ringer's solution was then infused to stabilize the aortic pressure to within 90% of its original 1 ATA baseline value. Hemodynamic parameters were measured or calculated at eight different times. There were statistically significant differences in some of the measured parameters due to the effects of hemorrhage but no differences between the three groups attributable to either of the hyperbaric conditions or the effects of lactated Ringer's solution.
D000388:Air; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005260:Female; D006439:Hemodynamics; D006931:Hyperbaric Oxygenation / Q000009:adverse effects*; D007552:Isotonic Solutions / Q000627:therapeutic use*; D008297:Male; D011312:Pressure / Q000009:adverse effects*; D000077325:Ringer's Lactate; D012771:Shock, Hemorrhagic / Q000188:drug therapy*; D013997:Time Factors
D007552:Isotonic Solutions; D000077325:Ringer's Lactate