Effector mechanisms in the pig. Antibody-dependent cellular cytolysis of African swine fever virus infected cells.
Antibody dependent cellular cytolysis (ADCC) against African swine fever virus infected nucleated cells was investigated in a porcine system. Of the peripheral blood components examined, only neutrophils acted as effectors. Lymph node derived cells displayed no ADCC activity. In vitro yield reduction assays suggested that neutrophil mediated ADCC may play a role in recovery from African swine fever virus infection.
D000357:African Swine Fever / Q000276:immunology; D000358:African Swine Fever Virus / Q000254:growth & development / Q000276:immunology*; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D000920:Antibody-Dependent Cell Cytotoxicity; D001854:Bone Marrow Cells; D002460:Cell Line; D007497:Iridoviridae / Q000276:immunology*; D008198:Lymph Nodes / Q000166:cytology; D008214:Lymphocytes / Q000276:immunology; D009504:Neutrophils / Q000276:immunology*; D013552:Swine
D000914:Antibodies, Viral