In vitro toxicity of n-hexane and 2,5-hexanedione using isolated perfused rabbit heart.
In vitro toxicity of n-hexane and 2,5-hexanedione using isolated perfused rabbit heart is reported. The hearts were perfused using Langendorf's procedure and modified Anderson's coronary perfusion apparatus. The force of cardiac contraction was significantly reduced following 1 h perfusion with 9.6 mg/l concentration of n-hexane and with 0.35% v/v concentration of 2,5-hexanedione.
D000818:Animals; D005260:Female; D006321:Heart / Q000187:drug effects*; D006586:Hexanes / Q000633:toxicity*; D006588:Hexanones / Q000633:toxicity*; D066298:In Vitro Techniques; D007659:Ketones / Q000633:toxicity*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000473:pathology; D011817:Rabbits
D006586:Hexanes; D006588:Hexanones; D007659:Ketones; C026385:n-hexane; C011269:2,5-hexanedione