Generalized lymphadenitis following B.C.G. vaccination in an immunocompetent 12-year-old boy.
An immunocompetent, healthy 12-year-old boy was presented with generalized large lymphadenopathy in the left side of the body, 1 month after a BCG vaccination with a regular dose. A Mantoux test before vaccination was negative. Histological and bacteriological findings from the largest lymph node biopsy revealed BCG'itis. The patient recovered spontaneously after 7 months. He was confirmed as being immunocompetent by normal serum immunoglobulin levels, normal B and T cell function tests, and a conversion of Mantoux test. BCG infections including lymphadenitis are rare and have been described hitherto mainly in infants, in immune deficient patients, or related to overdose. Such a complication must be taken into consideration when dealing with lymphadenopathy in healthy school-age children, who now undergo BCG vaccinations in many countries.
D001402:B-Lymphocytes; D001500:BCG Vaccine / Q000009:adverse effects*; D001706:Biopsy; D002648:Child; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008198:Lymph Nodes / Q000473:pathology; D008199:Lymphadenitis / Q000209:etiology* / Q000473:pathology; D008297:Male; D013601:T-Lymphocytes; D014376:Tuberculosis / Q000517:prevention & control*
D001500:BCG Vaccine; D007136:Immunoglobulins