Increased frequency of lymphocyte micronuclei in workers producing reinforced polyester resin with low exposure to styrene.
A new micronucleus method based on the analysis of lymphocytes with preserved cytoplasm revealed an increased frequency of micronuclei in 38 workers employed in a plant producing styrene-modified polyester resin as compared to the frequency in 20 referents (5.9 vs 3.6%). The time-weighted average of the styrene concentration in the workroom air varied between 1 and 36 ppm (mean 13 ppm) during the last year and correlated well to low urinary levels of mandelic acid, which ranged from 9 to 316 mg/g of creatinine (mean 65 mg/g of creatinine).
D000328:Adult; D000368:Aged; D002452:Cell Count; D002467:Cell Nucleus / Q000648:ultrastructure*; D004781:Environmental Exposure; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure*; D008297:Male; D008333:Mandelic Acids / Q000032:analysis; D008875:Middle Aged; D011091:Polyesters / Q000494:pharmacology; D012117:Resins, Synthetic / Q000494:pharmacology*; D013343:Styrenes / Q000494:pharmacology*
D008333:Mandelic Acids; D011091:Polyesters; D012117:Resins, Synthetic; D013343:Styrenes