Blockage of antiviral induction of interferon by homologous cell biochemical activity: effect of chicken embryo fibroblast mitotic cell cycle phases on Sindbis virus growth.
The antiviral activity of interferon, measured as the reduction of viral yield, was studied as a function of the cell cycle phases. The present study shows that cells which are about to enter DNA replication phase S and cells that are in mitosis phase M are not refractive to viral infection when treated with interferon. The growth of Sindbis virus, used as the challenger, dropped considerably at the G1-S junction, at mitosis phase M, and as cells entered into a deeper quiescent state.
D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D005347:Fibroblasts; D007370:Interferon Type I / Q000494:pharmacology*; D007399:Interphase; D008938:Mitosis; D012845:Sindbis Virus / Q000254:growth & development*
D007370:Interferon Type I