Prevention of adriamycin toxicity.
Mice treated with lethal doses of adriamycin (A1) (IP) are rescued with a single IP dose of 3,5,5-trimethyl-2-morpholinon-3-yl radical dimer (TM3). The in vivo rescue is assumed to be analogous to the in vitro reaction of TM3 with A1 that produces the non-toxic 7-deoxy-adriamycinone (7dAone). TM3 prevents death if given within 60 min following A1 administration. Control A1-treated mice died by 8 days (median survival time) whereas TM3 rescued A1-treated mice had a median survival time of greater than 60 days.
D000818:Animals; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004317:Doxorubicin / Q000633:toxicity*; D005260:Female; D005609:Free Radicals; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009025:Morpholines / Q000494:pharmacology*
D005609:Free Radicals; D009025:Morpholines; D004317:Doxorubicin; C039494:3,5,5-trimethyl-2-morpholinon-3-yl radical dimer; D004121:Dimethyl Sulfoxide