[The state of energy metabolism and lipid distribution in the livers of rats treated with phenobarbital and oil].
The relationship between the energy state of adenine nucleotides, mitochondrial oxidative phosphorylation, contents of long-chain acyl-CoAs in the liver and glycerolipid synthesis have been studied under different states of lipid metabolism. The "high fat" state which has been induced by intraperitoneal injections of corn oil was characterized by an increased level of the acyl-CoAs, inhibition of oxidative phosphorylation at the level of the adenine nucleotide carrier and by decreased phosphate potential values. An injection of phenobarbital alone produced only a weak effect on the acyl-CoA content in the liver or on the energy state of adenine nucleotides. However, when injected together with oil, phenobarbital abolished all the effects caused by oil injections. Studies on lipid distribution have demonstrated that in all the three metabolic models the synthesis of glycerolipids is enhanced, but the mechanisms of this increase are different. The role of long-chain acyl-CoAs in the integration of energy and lipid metabolism is discussed.
D000214:Acyl Coenzyme A / Q000378:metabolism*; D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D003314:Corn Oil; D004041:Dietary Fats / Q000494:pharmacology*; D004734:Energy Metabolism / Q000187:drug effects*; D005989:Glycerides / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D009821:Oils / Q000494:pharmacology*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats
D000214:Acyl Coenzyme A; D000227:Adenine Nucleotides; D004041:Dietary Fats; D005989:Glycerides; D009821:Oils; D003314:Corn Oil; D010634:Phenobarbital
Sostoianie énergeticheskogo metabolizma i raspredelenie lipidov v pecheni krys pri vvedenii fenobarbitala i masla.