Amoxycillin/clavulanic acid: the effect of probenecid.
The effect of probenecid on the combination of amoxycillin/clavulanic acid has been compared with the effect on amoxycillin alone and it has been shown that probenecid, whilst producing its expected effect on amoxycillin, did not affect the clavulanic acid concentration of the combination. A possible minor role for tubular secretion of clavulanic acid is discussed.
D000328:Adult; D000658:Amoxicillin / Q000378:metabolism*; D019980:Amoxicillin-Potassium Clavulanate Combination; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D002969:Clavulanic Acids / Q000378:metabolism*; D004338:Drug Combinations / Q000378:metabolism; D004347:Drug Interactions; D006801:Humans; D011339:Probenecid / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D004338:Drug Combinations; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin; D011339:Probenecid