The complete amino acid sequence of oncomodulin--a parvalbumin-like calcium-binding protein from Morris hepatoma 5123tc.
Oncomodulin is an acidic calcium-binding protein of 108 amino acids which has been detected only in tumors. The complete amino acid sequence of rat oncomodulin has been established, and the N-terminus shown to be N-acetylserine. Homology of the oncomodulin sequence with members of the troponin C superfamily of calcium-binding proteins was demonstrated, and putative calcium-binding domains were located. A further degree of homology was established between oncomodulin and the parvalbumins, including rat parvalbumin. Oncomodulin was therefore considered to be a parvalbumin-like calcium-binding protein.
D000595:Amino Acid Sequence; D000818:Animals; D002135:Calcium-Binding Proteins / Q000302:isolation & purification; D055598:Chemical Phenomena; D002621:Chemistry; D008114:Liver Neoplasms, Experimental / Q000032:analysis*; D009363:Neoplasm Proteins / Q000302:isolation & purification*; D010320:Parvalbumins; D010446:Peptide Fragments; D051381:Rats
D002135:Calcium-Binding Proteins; D009363:Neoplasm Proteins; D010320:Parvalbumins; D010446:Peptide Fragments; C034733:oncomodulin