Age-related susceptibility to aspirin-induced nephrotoxicity in female rats.
The effect of puberty on aspirin-induced renal necrosis in female Sprague-Dawley rats was observed. Rats aged 31 days were unaffected by aspirin administration, but 55-day-old rats showed segmental cortical tubular necrosis after a single dose of 1000 mg/kg of aspirin. Urinary gamma-glutamyl transpeptidase (gamma-GT) and proteinuria were useful non-invasive indicators of these necrotic changes.
D000367:Age Factors; D000818:Animals; D001241:Aspirin / Q000633:toxicity*; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D001241:Aspirin