The influence of phenacetin or mechanical perforation on the development of renal pelvic and urinary bladder tumors in FANFT-induced urinary tract carcinogenesis.
The influence of 0.535% phenacetin in the diet or mechanical perforation of the renal pelvis and urinary bladder of male Sprague-Dawley rats in FANFT-induced urinary tract carcinogenesis was studied. The 151 rats were divided into 5 experimental and one control group. The rats were followed for up to 80 weeks. FANFT administered at 0.2% in the diet for 11 weeks resulted in a high incidence of urinary tract tumors particularly of the renal pelvis. Similar results were obtained by administration of 0.2% FANFT for 6 weeks followed by 0.535% phenacetin while FANFT for 6 weeks preceded or followed by mechanical perforation of the renal pelvis resulted in a significantly lower incidence of renal pelvic tumors. Phenacetin appeared to enhance the development of renal pelvic tumors in FANFT-induced urinary tract carcinogenesis. In contrast no effect of phenacetin on the urinary bladder could be detected.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000209:etiology / Q000473:pathology; D002296:Carcinosarcoma / Q000139:chemically induced / Q000209:etiology / Q000473:pathology; D004198:Disease Susceptibility; D005200:FANFT / Q000008:administration & dosage; D006965:Hyperplasia / Q000139:chemically induced / Q000209:etiology / Q000473:pathology; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000209:etiology / Q000473:pathology*; D007682:Kidney Pelvis / Q000293:injuries* / Q000502:physiology; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D010615:Phenacetin / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration / Q000187:drug effects; D001743:Urinary Bladder / Q000293:injuries* / Q000502:physiology; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000209:etiology / Q000473:pathology*
D005200:FANFT; D010615:Phenacetin