Pathogenesis of K papovavirus infection in athymic nude mice.
The fatal outcome of K virus infection in infant mice and cytoxan-treated adult mice is related to their inability to mount a prompt antibody response to the virus. Athymic nude mice infected with K virus exhibited no clinical illness and no detectable virus-specific immunoglobulin G (IgG) response, but they did exhibit a low level of virus-specific immunoglobulin M response. Transfer of spleen cells from K virus-primed nude mice to infected infant mice conferred complete protection against K virus-induced mortality. This protection was diminished by the depletion of B cells but not by the depletion of adherent cells from the primed spleen cells. B cell response is therefore important in the recovery of nude mice from K virus infection.
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology*; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D027383:Papillomaviridae / Q000276:immunology*; D027382:Polyomaviridae; D013154:Spleen / Q000276:immunology; D014412:Tumor Virus Infections / Q000276:immunology*
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M