Toxicity of nitrite and dimethylamine in rats.
Weanling male Wistar strain rats were administered, through the drinking water, nitrite (0.2%) and dimethylamine (DMA) (0.2%), either singly or in combination for 9 months. Some animals also received 0.5% butylated hydroxytoluene (BHT) in the diet. Nitrite, as well as DMA, caused higher in vitro lipoperoxidation, free lysosomal enzyme activities and cytosolic superoxide dismutase activity in liver. Some of these increases viz., the enzyme activities in liver, were counteracted to a significant extent in the rats receiving a dietary supplement of BHT. The results indicate that nitrite and DMA may induce toxicity through some free radical reactions and that BHT can provide some protection.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002084:Butylated Hydroxytoluene / Q000633:toxicity*; D002403:Cathepsins / Q000378:metabolism; D004123:Dimethylamines / Q000633:toxicity*; D004347:Drug Interactions; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D009573:Nitrites / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000378:metabolism
D004123:Dimethylamines; D008054:Lipid Peroxides; D009573:Nitrites; D002084:Butylated Hydroxytoluene; D008315:Malondialdehyde; C034516:dimethylamine; D013482:Superoxide Dismutase; D000135:Acid Phosphatase; D002403:Cathepsins