Normal mice express idiotypes related to autoantibody idiotypes of lupus mice.
Spleen and fetal liver B cells of normal mice synthesized idiotypes shared by anti-DNA autoantibodies of genetically autoimmune mice. Some of the idiotypes were specific for DNA; the majority, however, were not. The findings indicate that the autoantibody idiotypes are related to a conserved family of antibody variable regions that are present in normal animals.
D000818:Animals; D000974:Antibodies, Antinuclear / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D004247:DNA / Q000378:metabolism; D005260:Female; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D008099:Liver / Q000196:embryology / Q000276:immunology; D008177:Lupus Vulgaris / Q000276:immunology*; D051379:Mice; D011247:Pregnancy; D011817:Rabbits; D013154:Spleen / Q000276:immunology
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; D007130:Immunoglobulin Idiotypes; D004247:DNA