title: Pressurized aerosol inhaler technique: how important are inhalation from residual volume, inspiratory flow rate and the time interval between puffs?
abstract: Forty-three patients with obstructive airways disease took part in three studies designed to determine the importance of three modes of inhalation of a beta 2-agonist on bronchodilator response. Under the conditions of the test, lung volume at the time of aerosol release and the time interval between the 2 puffs had no significant effect upon bronchodilator response, but a fast inspiratory flow rate was found to be associated with a significant reduction in response.
mesh_terms: D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000368:Aged; D000420:Albuterol / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007545:Isoproterenol / Q000008:administration & dosage*; D008173:Lung Diseases, Obstructive / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012123:Pulmonary Ventilation; D012115:Residual Volume; D012646:Self Administration / Q000379:methods; D013997:Time Factors
chemical_list: D000336:Aerosols; D007545:Isoproterenol; D000420:Albuterol