[Gas exchange and blood circulation status in dogs following replacement of acute blood loss by perfluoro compound emulsions].
Blood circulation and gas exchange were examined after replacement of blood loss (50 ml/kg bw) in dogs by a preparation containing perfluorocompound (PFC) emulsion (20 v. %) and protein-salt solution (PSS) consisting of isotonic solution of electrolytes and donor's albumin, the final concentration of the latter in the preparation being equal to 5%. Animals with analogous blood loss replaced by PSS alone served as control. Infusion of the preparation under study led to a steady recovery of the main parameters of the hemodynamics disordered as a result of blood loss. Its infusion to experimental animals was followed by a noticeable increase in oxygen blood capacity, provoked a more considerable elevation of pO2 in arterial and venous blood as compared to control. Compensation with PFS emulsion for homeostatic changes that occurred in dogs after blood loss involved a more active oxygen utilization, whereas in controls, a more considerable increase of cardiac output. The study drug is offered as base for a blood substitute-oxygen carrier.
D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage*; D004285:Dogs; D004338:Drug Combinations; D004655:Emulsions; D005466:Fluorocarbons / Q000008:administration & dosage*; D006439:Hemodynamics; D006470:Hemorrhage / Q000503:physiopathology / Q000628:therapy*; D011659:Pulmonary Gas Exchange
D001802:Blood Substitutes; D004338:Drug Combinations; D004655:Emulsions; D005466:Fluorocarbons; C039422:perfluorotripropylamine; C008805:perfluorodecalin
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