Analysis of the primary translational product and integrated DNA of a new feline sarcoma virus, GR-FeSV.
The Gardner-Rasheed strain of feline sarcoma virus (GR-FeSV), is a recent isolate of a naturally occurring cat sarcoma. The primary translational product of GR-FeSV (GR P70) was shown to be a phosphoprotein with associated tyrosine-specific protein kinase activity. The relationship between the GR-FeSV provirus and once genes of other transforming retroviruses known to code for tyrosine kinases was examined by molecular hybridization. Probes repesenting onc genes of Snyder-Theilen and McDonough strains of feline sarcoma virus, Rous sarcoma virus, and Abelson murine leukemia virus did not detectably hybridize integrated GR-FeSV. These findings suggest that GR-FeSV contains a distinct tyrosine kinase-coding onc gene.
D000818:Animals; D004279:DNA, Viral / Q000032:analysis*; D009693:Nucleic Acid Hybridization; D010750:Phosphoproteins / Q000032:analysis; D014176:Protein Biosynthesis; D011494:Protein Kinases / Q000235:genetics; D011505:Protein-Tyrosine Kinases; D014764:Viral Proteins / Q000032:analysis
D004279:DNA, Viral; D010750:Phosphoproteins; D014764:Viral Proteins; D011494:Protein Kinases; D011505:Protein-Tyrosine Kinases