Epiglottitis due to ampicillin-tolerant Haemophilus influenzae type b.
Tolerance to beta-lactam antibiotics has been described with staphylococci and enterococci, but this phenomenon and its clinical significance in Haemophilus influenzae has not been reported. We have reported a case of bacteremic epiglottitis due to an ampicillin-tolerant, beta-lactamase-negative strain of Haemophilus influenzae type b which was cured with ampicillin therapy alone. The organism was not tolerant to moxalactam, cefotaxime, or rifampin. Rifampin therapy eliminated pharyngeal carriage.
D000667:Ampicillin / Q000008:administration & dosage / Q000494:pharmacology*; D002555:Cerebrospinal Fluid / Q000382:microbiology; D004359:Drug Therapy, Combination; D004826:Epiglottitis / Q000209:etiology*; D006192:Haemophilus Infections / Q000188:drug therapy*; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D007827:Laryngitis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010403:Penicillin Resistance; D010614:Pharynx / Q000382:microbiology; D012293:Rifampin / Q000008:administration & dosage
D000667:Ampicillin; D012293:Rifampin