Anticarcinoma activity in vivo of rhodamine 123, a mitochondrial-specific dye.
Carcinoma cells and normal epithelial cells differ in the mitochondrial retention of a permeant cationic compound, rhodamine 123. The possibility of utilizing this difference in carcinoma chemotherapy was investigated. Rhodamine 123 exhibited anticarcinoma activity in mice, and this activity was potentiated by 2-deoxyglucose.
D000818:Animals; D002277:Carcinoma / Q000188:drug therapy*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D002460:Cell Line; D003847:Deoxyglucose / Q000627:therapeutic use; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004734:Energy Metabolism / Q000187:drug effects; D051379:Mice; D008928:Mitochondria / Q000187:drug effects; D020112:Rhodamine 123; D012235:Rhodamines / Q000627:therapeutic use*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy*; D014966:Xanthenes / Q000627:therapeutic use*
D012235:Rhodamines; D014966:Xanthenes; D020112:Rhodamine 123; D003847:Deoxyglucose