Presence of H-Y antigen in female patients with sex-chromosome mosaics and absence of testicular tissue.
H-Y antigen was tested in five women with sex chromosome mosaicism and gonadal streaks. Three patients had a 45,X/46,XY or 46,X,der(Y) and two a 45,X/46,X, der(X) chromosome constitution. All patients were H-Y antigen positive. Lack of testis differentiation in these women may be explained by subthreshold expression of H-Y antigen, different H-Y antigen molecules, and/or different tissue distribution of the chromosome mosaicism.
D000293:Adolescent; D000328:Adult; D000818:Animals; D005260:Female; D005796:Genes; D006059:Gonadal Dysgenesis / Q000235:genetics*; D006060:Gonadal Dysgenesis, Mixed / Q000235:genetics*; D006182:H-Y Antigen / Q000032:analysis / Q000235:genetics*; D006801:Humans; D007106:Immune Sera; D007621:Karyotyping; D008297:Male; D009030:Mosaicism; D051381:Rats; D011917:Rats, Inbred Lew; D012730:Sex Chromosomes; D013737:Testis
D006182:H-Y Antigen; D007106:Immune Sera