Effect of trimethyltin on hepatic and extra-hepatic non-protein sulfhydryl levels in the mouse.
Administration of trimethyltin (TMT) ip to mice lowered non-protein sulfhydryl (NPSH) levels in a tissue-specific and dose-dependent manner. Incubation of TMT with GSH and mouse hepatic cytosol did not result in conjugation of TMT, as evidenced by the lack of reduction of GSH levels. Additionally, TMT in vivo did not increase oxidized glutathione (GSSG) levels, nor did it alter hepatic ATP content. These results suggest that TMT decreased NPSH levels in vivo by either directly inhibiting GSH synthesis or by inhibiting uptake of precursor amino acids.
D000818:Animals; D005978:Glutathione / Q000032:analysis; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis* / Q000187:drug effects; D008297:Male; D051379:Mice; D013438:Sulfhydryl Compounds / Q000032:analysis*; D014220:Trialkyltin Compounds / Q000633:toxicity*; D014298:Trimethyltin Compounds / Q000633:toxicity*
D013438:Sulfhydryl Compounds; D014220:Trialkyltin Compounds; D014298:Trimethyltin Compounds; D005978:Glutathione