Pulmonary vascular effects of amrinone in conscious lambs.
The direct pulmonary vascular effects of amrinone, a nonglycoside, noncatechole cardiotonic agent were studied in conscious newborn lambs using a double-flow probe preparation that allows separation of direct and indirect pulmonary vascular effects. Amrinone was found to be a direct pulmonary vasodilator with a threshold dose of 0.3 mg/kg. Amrinone also increased cardiac output and decreased aortic pressure at somewhat higher threshold doses (1.0 mg/kg and 3.0 mg/kg, respectively). Amrinone's peak effect on pulmonary resistance appeared greater than its peak systemic effects. These effects were noted in both normoxia and hypoxia, and were not changed by pretreatment with propranolol.
D000631:Aminopyridines / Q000494:pharmacology*; D000676:Amrinone; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002316:Cardiotonic Agents / Q000494:pharmacology*; D005260:Female; D000860:Hypoxia / Q000503:physiopathology; D008297:Male; D011433:Propranolol / Q000494:pharmacology; D011652:Pulmonary Circulation / Q000187:drug effects*; D012756:Sheep; D014655:Vascular Resistance / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects
D000631:Aminopyridines; D002316:Cardiotonic Agents; D011433:Propranolol; D000676:Amrinone