RNA tumor virus production accompanies the transformed phenotype change induced by hydrocortisone hormone in rat glioma cells.
ST1, a hydrocortisone-hypersensitive variant of the C6 rat glioma cell line, produced viral particles upon treatment with this glucocorticoid hormone. The virus was identified as type C RNA tumor virus by: a) morphology; b) 3H-uridine labelling; c) banding in sucrose density gradient; d) reverse transcriptase activity. Hydrocortisone uniquely shut off ST1 cells' transformed phenotype and turned on viral particles production.
D000818:Animals; D002460:Cell Line; D002472:Cell Transformation, Viral; D005910:Glioma / Q000382:microbiology*; D006854:Hydrocortisone / Q000494:pharmacology*; D051381:Rats; D012190:Retroviridae / Q000254:growth & development*; D014775:Virus Activation / Q000187:drug effects
D006854:Hydrocortisone