Developmental pattern of DNA and proteins in brain, liver, lung and heart of rats given excess vitamin A postnatally.
The effect of an excessive dose of vitamin A (1,000 IU) to rat pups on 4, 6, 8 and 10 days of age was studied on growth and organ weights. The effects on the amounts of DNA and proteins and incorporation of 3H-thymidine into DNA and 3H-leucine into proteins of brain, liver, lung and heart was studied on 11, 17 and 23 days of age. Excess vitamin A administration affected the postnatal development of DNA and protein metabolism of these organs differently.
D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism; D002452:Cell Count; D004247:DNA / Q000378:metabolism*; D005260:Female; D006128:Growth; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014801:Vitamin A / Q000008:administration & dosage*
D011506:Proteins; D014801:Vitamin A; D004247:DNA