Accommodation of skeletal muscle in rats under hypoxic conditions induced by tourniquet.
Resting membrane potential (RMP) and indexes of accommodation (IA) were obtained from the brachioradialis muscle in rats subjected to 2 or 5 h of bilateral hindlimb tourniquet. The results showed a highly significant increase in muscular IA with a return to the control values for the rats with 2 h of tourniquet, while the increased in the IA is maintained all the survival period in the rats with 5 h of tourniquet. The velocity of increasing of the IA bears a direct relationship to the outcome of the injury. A decrease in the RMP of the brachioradialis muscle and an increase in the extracellular K+ and H+ was also observed. The early differences in the behavior of the accommodation parameter allowed a clear differentiation of the rats which survived the tourniquet shock from those who finally died.
D000818:Animals; D004558:Electric Stimulation; D006614:Hindlimb / Q000098:blood supply; D007511:Ischemia; D008297:Male; D008564:Membrane Potentials; D009119:Muscle Contraction; D009132:Muscles / Q000098:blood supply / Q000503:physiopathology*; D010100:Oxygen; D051381:Rats; D011919:Rats, Inbred Strains; D012769:Shock / Q000503:physiopathology*; D014111:Tourniquets
D010100:Oxygen