title: Aberrations of chromosome 3. A marker of T-cell lymphomas?
abstract: Aberrations of chromosome occur in different malignancies, but they are more frequent in lymphoproliferative ones than in the others. In this study here four out of five T-zone lymphomas had abnormalities of chromosome 3. This lead to the question of whether aberrations of chromosome 3 might be a marker of T-cell lymphomas. The conclusion which can be drawn from the cases described in the literature, the own unpublished cases, and these four T-zone lymphomas is that abnormalities of chromosome 3 cannot be regarded as a discriminative marker of T-cell derived malignancies. It is suggested that the relationship between chromosome aberrations and type of disease is not necessarily a direct one. One possible model of the genesis of chromosome aberrations in malignant diseases is presented.
mesh_terms: D002869:Chromosome Aberrations; D002900:Chromosomes, Human, 1-3 / Q000648:ultrastructure*; D005819:Genetic Markers; D006689:Hodgkin Disease / Q000235:genetics; D006801:Humans; D008223:Lymphoma / Q000235:genetics*; D013601:T-Lymphocytes / Q000648:ultrastructure; D014314:Trisomy
chemical_list: D005819:Genetic Markers