Equal distribution of T-lymphocyte subpopulations in thymus and spleen cells of NZB and BALB/c mice.
NZB mice develop an autoimmune disease of unknown etiology. Since the detection of immunoregulatory T-cells it has been speculated that disbalances of these cells may be important in the course of the NZB disease. By utilization of monoclonal antibody defining immunoregulatory Lyt subsets and a FACS IV system we investigated whether differences in the number and/or marker densities of given subsets exist between NZB and the normal reference strain BALB/c. Newborn animals and animals up to 60 weeks of age were tested. No significant difference in the percentages nor in the marker densities of theta+, Lyt 1+, and Lyt 2+ cells was observed at any age or sex, neither in spleen nor in thymus. It is concluded the autoimmune disease of NZB is not influenced by the parameters investigated.
D000375:Aging; D000818:Animals; D005434:Flow Cytometry; D007958:Leukocyte Count; D051379:Mice; D008807:Mice, Inbred BALB C / Q000033:anatomy & histology*; D008814:Mice, Inbred NZB / Q000033:anatomy & histology*; D013154:Spleen / Q000166:cytology*; D013601:T-Lymphocytes / Q000145:classification / Q000166:cytology*; D013950:Thymus Gland / Q000166:cytology*