[Effect of alpha-tocopherol on superoxide dismutase and glutathione lipoperoxidase activities of mouse liver cytosol and mitochondria].
The maximal radioactivity of mouse liver cytosol was observed 18 hours after intraperitoneal injection of 5-CH3-[3H] alpha-tocopherol emulsion with Tween 80. Intraperitoneal injections of Tween 80 (500 mg/kg) without alpha-tocopherol significantly decreased the glutathione lipoperoxidase and superoxide dismutase activities of liver cytosol. Vitamin E effect on the glutathione lipoperoxidase activity was weakly pronounced, while the superoxide dismutase activities of cytosol and liver mitochondria were markedly increased thereby. It was assumed that natural free radical scavengers can induce enzymatic utilization of superoxide radical anions, while synthetic free radical scavengers can trigger on enzymatic systems of lipoperoxide utilization.
D000818:Animals; D003600:Cytosol / Q000201:enzymology; D005979:Glutathione Peroxidase / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008930:Mitochondria, Liver / Q000201:enzymology; D011136:Polysorbates; D013482:Superoxide Dismutase / Q000378:metabolism*; D014810:Vitamin E / Q000494:pharmacology*
D011136:Polysorbates; D014810:Vitamin E; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase
Vliianie al'fa-tokoferola na superoksiddismutaznuiu i glutationlipoperoksidaznuiu aktivnosti tsitozolia i mitokhondriĭ pecheni mysheĭ.