title: The effect of experimental hydronephrosis on clearance data.
abstract: Partial obstruction of one ureter was created in newborn rats and its effects were studied in the adult rat. The obstructed renal pelvis was found to be enlarged 2-3 times. The weight of the kidney on this side was 85% of the contralateral one. Inulin clearance was measured in a way, which allowed comparison between the conventional technique and a modified technique, designed to circumvent the dilution in the enlarged pelvis. With the conventional technique, filtration was 32% of that in the contralateral kidney, whereas with the new technique true filtration of the hydronephrotic kidney was 82% (p less than 0.001). The modified technique is evaluated and the implications of the functional results are discussed.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D005069:Evaluation Studies as Topic; D005919:Glomerular Filtration Rate; D006869:Hydronephrosis / Q000503:physiopathology* / Q000652:urine; D007444:Inulin / Q000652:urine; D007682:Kidney Pelvis / Q000473:pathology; D008297:Male; D008722:Methods; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D007444:Inulin