Synthesis of putative oxidized metabolites of 8-methylbenzo[a]pyrene.
Synthesis is described of trans-7,8-dihydroxy-7,8-dihydro-8-methylbenzo[a]pyrene and trans-7,8-dihydroxy-anti-9,10-epoxy-8-methyl-7,8,9,10-tetrahydrobenzo[a] pyrene, potential proximate and ultimate carcinogenic metabolites, respectively, of 8-methylbenzo[a]pyrene.
D001580:Benzopyrenes / Q000138:chemical synthesis* / Q000378:metabolism*; D055598:Chemical Phenomena; D002621:Chemistry; D004101:Dihydroxydihydrobenzopyrenes; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D008968:Molecular Conformation; D013056:Spectrophotometry, Ultraviolet
D001580:Benzopyrenes; D004101:Dihydroxydihydrobenzopyrenes; C039383:8-methylbenzo(a)pyrene; C039384:7,8-dihydroxy-7,8-dihydro-8-methylbenzo(a)pyrene; C039385:7,8-dihydroxy-9,10-epoxy-8-methyl-7,8,9,10-tetrahydrobenzo(a)pyrene