Activation of a type C virus particle in cells from the inbred mouse strain 129/J: antigenic relationship with the horizontally transmitted type C viruses of primates. Brief report.
We have activated a thymus-derived fibroblast cell line from 129/J mice for production of noninfectious type C viral particles. Retroviral particles were produced continuously after cells were treated with ethylnitrosourea, a powerful mutagen and carcinogen. Antigenic analysis of the major structural protein of these particles showed a close relationship with an infectious virus from Mus caroli, a potential progenitor of the horizontally transmitted primate type C viruses. This finding demonstrates the potential of cells from inbred strains of Mus musculus to express upon mutagenesis antigens of the Mus caroli class of endogenous MuLV.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D005038:Ethylnitrosourea / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains / Q000382:microbiology*; D009154:Mutation; D011323:Primates / Q000382:microbiology*; D012328:RNA Viruses / Q000254:growth & development* / Q000276:immunology; D013045:Species Specificity; D014771:Virion / Q000254:growth & development* / Q000276:immunology; D014775:Virus Activation; D014776:Virus Cultivation
D000956:Antigens, Viral; D005038:Ethylnitrosourea