title: Analysis of the base substitutions found in the Xenopus laevis 5 S RNA pseudogene.
abstract: A 5 S RNA pseudogene is associated with the major oocyte 5 S RNA gene of Xenopus laevis. X. borealis has several oocyte specific 5 S RNA genes. Gene 1 is the dominant 5 S RNA gene. Gene 3 has sometimes been referred to as a pseudogene. We show that the base substitutions in the X. laevis 5 S pseudogene are non-random with respect to double and single-stranded regions of the 5 S RNA using the chi 2 test of homogeneity with Yates correction for continuity. In addition, conserved positions of eukaryotic 5 S RNAs are predominantly maintained. X. borealis gene 3 is random in mutations.
mesh_terms: D000818:Animals; D001483:Base Sequence; D005260:Female; D005796:Genes; D008970:Molecular Weight; D009154:Mutation; D009690:Nucleic Acid Conformation; D009865:Oocytes / Q000502:physiology*; D012335:RNA, Ribosomal / Q000235:genetics*; D014981:Xenopus / Q000235:genetics*
chemical_list: D012335:RNA, Ribosomal