Promotive effects of thiobenzamide on liver carcinogenesis.
Thiobenzamide (a thiono-sulfur-containing xenobiotic), when administered to male Sprague-Dawley rats primed with a single low dose of diethylnitrosamine, enhances the number and size of both gamma-glutamyltranspeptidase-positive hepatocellular foci and cholangiofibrotic areas. Its effect seems to be greater than that of the known promoter phenobarbital.
D000577:Amides / Q000494:pharmacology*; D000818:Animals; D003043:Cocarcinogenesis; D004052:Diethylnitrosamine / Q000633:toxicity*; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D009602:Nitrosamines / Q000633:toxicity*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013854:Thioamides / Q000494:pharmacology*
D000577:Amides; D009602:Nitrosamines; D013854:Thioamides; D004052:Diethylnitrosamine; C015539:thiobenzamide; D010634:Phenobarbital