Local neurotoxicity of methylmethacrylate monomer.
A technique was devised which allowed a controlled exposure to methylmethacrylate liquid on rat tail skin. The procedure was repeated 3 h daily for 8 weeks. This caused keratolysis without ulcerations in the exposed skin and abnormal muscle responses to stimulation of the rat tail motor nerves by a skin electrode through the treated area after 4 weeks of exposure. The motor conduction time did not differ from controls. The results point to a local neurotoxic reaction by the absorbed methylmethacrylate. This technique may prove valuable in experiments on the determination of dermal and local toxicity of new chemicals.
D000818:Animals; D008297:Male; D008768:Methylmethacrylates / Q000633:toxicity*; D009431:Neural Conduction / Q000187:drug effects; D010525:Peripheral Nerves / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000187:drug effects
D008768:Methylmethacrylates