Org 4333, a potent, irreversibly binding estrogen agonist.
Two synthetic routes to 11 beta-chloromethylestra-1,3,5(10)-trien-3,17 beta-diol (Org 4333) are described. In biological tests this compound was found to be a potent irreversibly binding estrogen agonist.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004958:Estradiol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D005260:Female; D051381:Rats; D014599:Uterus / Q000187:drug effects
D004958:Estradiol; C038957:11-beta-chloromethyl-estradiol