title: Histiocytosis X: rate and pattern of resolution of osseous lesions.
abstract: Resolution rate and qualitative characteristics of healing were studied in 71 osseous lesions of histiocytosis X. Rates of healing, as assessed planimetrically and by vertebral body-height measurement, did not differ significantly among lesions that were treated with chemotherapy alone, chemotherapy plus radiation, radiation alone, or those that received no treatment. Lesions of Letterer-Siwe disease, Hand-Schuller-Christian disease, multiple eosinophilic granuloma, and solitary eosinophilic granuloma resolved at comparable rates. A trend toward more rapid healing was noted in younger children. Lesions treated with radiation alone showed a greater tendency to resolve with sclerosis, but radiographic healing characteristics did not strictly depend upon specific mode of therapy. These results support the concept of osseous histiocytosis X as a benign self-limited disorder when systemic disease is absent, and they encourage therapeutic conservatism.
mesh_terms: D001847:Bone Diseases / Q000000981:diagnostic imaging* / Q000628:therapy; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004359:Drug Therapy, Combination; D004803:Eosinophilic Granuloma / Q000000981:diagnostic imaging / Q000628:therapy; D005260:Female; D006646:Histiocytosis, Langerhans-Cell / Q000000981:diagnostic imaging* / Q000628:therapy; D006801:Humans; D007223:Infant; D008297:Male; D011859:Radiography; D011879:Radiotherapy Dosage