Substituted (2-phenoxyphenyl)acetic acids with antiinflammatory activity. 1.
The synthesis and antiinflammatory activity of a series of substituted (2-phenoxyphenyl)acetic acids are described. Initial screening in the adjuvant arthritis test showed that halogen substitution in the phenoxy ring enhanced activity considerably. Ulcerogenic potential, as measured by the minimum ulcerogenic dose (MUD), was low in almost all the acids tested. [2-(2,4-Dichlorophenoxy)phenyl]acetic acid possessed the most favorable combination of potency with low toxicity, including ulcerogenicity, and this compound is now in therapeutic use.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D007202:Indicators and Reagents; D010648:Phenylacetates / Q000627:therapeutic use*; D051381:Rats; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D007202:Indicators and Reagents; D010648:Phenylacetates; C012970:fenclofenac