[Effect of somatotropin on the activity of mitochondrial alpha-glycerophosphate dehydrogenase in the liver of rats with hypo- and hyperthyroidism].
The activity of mitochondrial alpha-glycerophosphate dehydrogenase in the liver of rats with hypothyrosis (two weeks after total thyroidectomy) is 36% of the normal level; in rats with hyperthyrosis (three weeks after subcutaneous implantation 2 mg of l-thyroxin on a kaolin base) it is 7.4 times as high. Bovine somatotropin (0.5 mg per 100 g of body mass) injected subcutaneously for 10 days has no effect on the enzyme activity in intact rats and in rats with hypothyrosis. In animals with hyperthyrosis somatotropin produces a 37% decrease in the enhance activity of the enzyme. Somatotropin fully normalizes a 25% increased amount of protein in the liver mitochondrial fractions of rats with hyperthyrosis.
D000818:Animals; D004790:Enzyme Induction; D005993:Glycerolphosphate Dehydrogenase / Q000096:biosynthesis*; D013006:Growth Hormone / Q000502:physiology*; D006980:Hyperthyroidism / Q000201:enzymology*; D007037:Hypothyroidism / Q000201:enzymology*; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology*; D051381:Rats; D011919:Rats, Inbred Strains; D013965:Thyroidectomy
D013006:Growth Hormone; D005993:Glycerolphosphate Dehydrogenase
Vliianie somatotropina na aktivnost' mitokhondrial'noĭ alpha-glitserofosfatdegidrogenazy v pecheni krys s gipo- i gipertireozom.