The temporal lobe in dementia of Alzheimer's type.
Evidence is presented of a predilection of neurofibrillary tangle formation and choline acetyltransferase deficiency for the temporal lobe in Alzheimer's disease. Together with evidence from studies of cerebral atrophy, 5-HT levels, and clinical findings, this indicates that changes in the temporal lobe may play a prominent role in Alzheimer's disease, especially in elderly patients.
D000368:Aged; D000544:Alzheimer Disease / Q000201:enzymology / Q000473:pathology*; D002795:Choline O-Acetyltransferase / Q000172:deficiency*; D003704:Dementia / Q000201:enzymology / Q000473:pathology; D005625:Frontal Lobe / Q000201:enzymology / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009454:Neurofibrils / Q000473:pathology*; D013702:Temporal Lobe / Q000201:enzymology / Q000473:pathology*
D002795:Choline O-Acetyltransferase