Testes weight reflect ethylnitrosourea induced histopathology in mice.
The powerful mutagen/carcinogen ethylnitrosourea (ENU) decreases testis weight in mice. A histopathological cause was determined for this effect. Groups of 3 mice were injected with 0, 50, 100 or 200 mg ENU/kg b.w. and were killed 1, 2, 4, 5, 7, 9, 13 or 15 weeks later. Microscopic examination of PAS-hematoxylin-stained sections showed a dose-and-time-dependent loss of germ cells from the seminiferous tubules 1-7 weeks after treatment followed by recovery from the damage. Testis weight decrease and recovery followed a similar course.
D000818:Animals; D005038:Ethylnitrosourea / Q000633:toxicity*; D007248:Infertility, Male / Q000139:chemically induced; D007700:Kinetics; D008297:Male; D051379:Mice; D009607:Nitrosourea Compounds / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D013737:Testis / Q000187:drug effects / Q000473:pathology*
D009607:Nitrosourea Compounds; D005038:Ethylnitrosourea