Hepatic changes in a patient with alpha 1-antitrypsin deficiency (MZ phenotype). Portal tract elastosis and noncirrhotic portal hypertension.
A 57-year-old woman with rheumatoid arthritis and alpha 1-antitrypsin deficiency (PiMZ phenotype), recovering from intraabdominal sepsis in association with gastric ulcer perforation, had portal hypertension. An operative liver biopsy specimen showed a distinctive elastosis of the portal tracts without cirrhosis.
D004547:Elastic Tissue / Q000473:pathology*; D005260:Female; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology* / Q000473:pathology; D008099:Liver / Q000473:pathology; D008875:Middle Aged; D010641:Phenotype; D011168:Portal System / Q000473:pathology*; D019896:alpha 1-Antitrypsin Deficiency