title: 3-Alkyl-2-aryl-3H-naphth[1,2-d]imidazoles, a novel class of nonacidic antiinflammatory agents.
abstract: Novel 3-alkyl-2-aryl-3H- naphth [1,2-d]imidazoles were synthesized and evaluated as antiinflammatory agents in the carrageenin-induced paw edema, cotton pellet induced granuloma, and adjuvant-induced polyarthritis assays in rats. The analgesic, antipyretic, and gastroulcerogenic effects were also tested. Structure-activity relationships are discussed. One of the compounds, 3-(1-methylethyl)-2-(4-methoxyphenyl)-3H- naphth [1,2-d]imidazole (35), was selected for clinical trials as a nonacidic antiinflammatory and analgesic agent.
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis* / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000188:drug therapy; D006099:Granuloma / Q000188:drug therapy; D007093:Imidazoles / Q000138:chemical synthesis* / Q000627:therapeutic use; D007202:Indicators and Reagents; D008297:Male; D009281:Naphthalenes / Q000138:chemical synthesis* / Q000627:therapeutic use; D010146:Pain / Q000503:physiopathology; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy; D013329:Structure-Activity Relationship
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D007093:Imidazoles; D007202:Indicators and Reagents; D009281:Naphthalenes