title: The effects of levonantradol on rewarding brain stimulation thresholds in the rat.
abstract: Rats were implanted bilaterally with electrodes aimed at the medial forebrain bundle (MFB) and trained to deliver intracranial stimulation. Reward thresholds were determined using a modification of the psychophysical method of limits. Levonantradol, a cannabinoid with reported analgesic activity, was tested at doses between 0.0125 to 0.3 mg/kg. Significant elevations of reward thresholds were observed at 0.2 and 0.3 mg/kg. Since none of the doses tested lowered the reward threshold, an effect believed to be predictive of abuse, these results suggest that levonantradol has little or no abuse liability.
mesh_terms: D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D008297:Male; D010617:Phenanthridines / Q000494:pharmacology*; D051381:Rats; D012201:Reward; D013237:Stereoisomerism
chemical_list: D000700:Analgesics; D010617:Phenanthridines; C025490:nantradol