[Clinico-immunologic correlations in disseminated sclerosis].
The intensity of cellular and humoral immunity was shown to correlate with the acuteness and severity of disseminated sclerosis in 107 patients. During disease exacerbations, the patients displayed a decreased activity of T lymphocytes, which was determined by lymphocyte blast transformation, as well as high levels of cerebral, and low ones of complement fixing antibodies. The intensity of cellular reactivity was reduced in subjects with the most unfavourable, steadily progressing disease. The data obtained point to the necessity of a differential approach toward the immunotherapy of disseminated sclerosis. The deviations in the cellular and humoral phases of patients' immunity should be also taken into account.
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001921:Brain / Q000276:immunology*; D003168:Complement Fixation Tests; D003602:Cytotoxicity, Immunologic; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology*; D012075:Remission, Spontaneous; D013601:T-Lymphocytes / Q000276:immunology*
D001323:Autoantibodies
Kliniko-immunologicheskie sopostavleniia pri rasseiannom skleroze.