[General pharmacology of traxanox sodium. I. Effects on the central, somatic, and autonomic nervous systems, digestive system, urologic organs, and reproductive system].
Traxanox at the upper dose of 300 mg/kg, p.o., showed no effect on the somatic and autonomic nervous systems in the various tests. This agent caused some relaxation of the guinea pig tracheal strip in the resting tone at a concentration of 10(-6)M or more; however, its activity was less potent than that of isoproterenol and paraverine. Traxanox had no competitive antagonistic action against chemical mediators. Treatment of rats with this agent (3 mg/kg, i.v., or 10 mg/kg, s.c.) resulted in an inhibition of gastric (acid) secretion. Intravenous injections of traxanox (1-10 mg/kg) in dogs caused an immediate but transient inhibition of gastric and jejunal movement, and after a short time, slight potentiation of the latter; however, pretreatment with atropine prevented this latter potentiation. In the in vitro test, 10(-4)M traxanox caused contraction of the guinea pig ileum, a response which was inhibited by atropine. Traxanox (300 mg/kg, p.o.), however, did not show any effects on gastrointestinal propulsion in mice, nor did it have any effect on the gastrointestinal mucosa, gastric ulcers or bile secretion in rats. Traxanox (300 mg/kg, p.o.) showed a diuretic action in both normal and adrenoectomized rats. This action, however, was not observed in the rats treated with indomethacin (1 mg/kg, i.p.). This agent (10 mg/kg, i.v.) suppressed the spontaneous uterine contractions of pregnant rats in some cases. These findings suggest that traxanox at doses (1-5 mg/kg, p. o.) showing antiallergic activity has little effect on the central, somatic and autonomic nervous systems, digestive system, urinary organs and reproductive organs.
D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects*; D001777:Blood Coagulation / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects*; D002867:Chromones / Q000494:pharmacology*; D004064:Digestive System / Q000187:drug effects*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000494:pharmacology*; D066298:In Vitro Techniques; D050356:Lipid Metabolism; D008297:Male; D051379:Mice; D010913:Pituitary-Adrenal System / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D012702:Serotonin Antagonists; D014566:Urogenital System / Q000187:drug effects*
D002867:Chromones; D006633:Histamine Antagonists; D012702:Serotonin Antagonists; C020178:traxanox; D005947:Glucose