The arsonomethyl analogue of 3-phosphoglycerate.
4-Arsono-2-hydroxybutanoic acid, the analogue of 3-phosphoglycerate in which -CH2-AsO3H2 replaces -O-PO3H2, was synthesized. It proved to be a substrate for phosphoglycerate kinase. Its Michaelis constant was only slightly higher than that of the natural substrate, but its catalytic constant was about 1300 times smaller.
D001151:Arsenic / Q000138:chemical synthesis*; D006885:Hydroxybutyrates / Q000138:chemical synthesis*; D007700:Kinetics; D010735:Phosphoglycerate Kinase / Q000378:metabolism
D006885:Hydroxybutyrates; C038911:4-arsono-2-hydroxybutanoic acid; D010735:Phosphoglycerate Kinase; D001151:Arsenic