Antibody responses to honey-bee venom and monomethoxy-polyethylene glycol-modified honey-bee venom in mice.
Antibody responses of the IgE isotype were raised in mice with honey-bee venom (HBV) administered in alum or by daily injections without adjuvant. The sensitized mice were treated with single injections of HBV modified with monomethoxy-polyethylene glycol. By such treatment with modified but not with natural HBV, suppression of the IgE antibody responses was achieved. The IgG antibody responses, in contrast, were unchanged or enhanced.
D000276:Adjuvants, Immunologic / Q000276:immunology; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D000917:Antibody Formation; D001514:Bee Venoms / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D007114:Immunization; D007073:Immunoglobulin E / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D051379:Mice; D008808:Mice, Inbred CBA; D011092:Polyethylene Glycols / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000888:Antibodies, Anti-Idiotypic; D001514:Bee Venoms; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D011092:Polyethylene Glycols; C028210:monomethoxypolyethylene glycol