title: [Mechanism of natural penicillin resistance in the causative agent of tularemia].
abstract: beta-Lactamase and penicillinacylase were detected in the tularemia causative agent. These enzymes participated in the mechanism of natural resistance of the microorganisms to penicillins. It was shown that the growth temperature had a significant effect on the beta-lactamase activity. The penicillin resistance marker was not eliminated with the use of acridine orange, ethidium bromide or sodium dodecylsulfate.
mesh_terms: D005604:Francisella tularensis / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D005819:Genetic Markers / Q000187:drug effects; D010399:Penicillin Amidase / Q000032:analysis / Q000378:metabolism; D010403:Penicillin Resistance; D010405:Penicillinase / Q000032:analysis / Q000378:metabolism; D013696:Temperature; D014774:Virulence
chemical_list: D005819:Genetic Markers; D010399:Penicillin Amidase; D010405:Penicillinase
vernacular_title: Mekhanizm prirodnoĭ penitsllinoustoĭchivosti u vozbuditelia tuliaremii.