Growth hormone increases neonatal mouse urine epidermal growth factor.
The effects of bovine growth hormone (bGH) and triiodothyronine (T3), alone and in combination, were studied on urinary-EGF (U-EGF) in newborn mice. All three treatments significantly augmented the concentration of U-EGF. The effect was far greater for T3 than for bGH. No EGF response was seen in submandibular gland or kidney tissues suggesting that, in newborn animals, these hormones selectively modulate U-EGF.
D000818:Animals; D000831:Animals, Newborn; D004815:Epidermal Growth Factor / Q000652:urine*; D013006:Growth Hormone / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D013363:Submandibular Gland / Q000187:drug effects; D014284:Triiodothyronine / Q000494:pharmacology
D014284:Triiodothyronine; D004815:Epidermal Growth Factor; D013006:Growth Hormone