Comparison of fecal blood loss after use of aspirin and diflunisal.
Diflunisal 1,000 mg/day, aspirin 4.0 g/day, or placebo were given to 36 healthy volunteers for 14 days to determine fecal blood loss. There was a significant increase in fecal blood loss from baseline in the aspirin group compared to both the diflunisal and placebo groups. A slight but significant increase in fecal blood loss in the diflunisal group at Week 1 was reported; however, there was no significant increase at Week 2. Use of diflunisal was not associated with any consistent blood loss or serious adverse reactions.
D001241:Aspirin / Q000009:adverse effects*; D004061:Diflunisal / Q000009:adverse effects*; D005243:Feces; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced*; D006801:Humans; D008297:Male; D012459:Salicylates / Q000009:adverse effects*; D013997:Time Factors
D012459:Salicylates; D004061:Diflunisal; D001241:Aspirin