Azlocillin concentrations in human aqueous humor after intravenous and subconjunctival administration.
Twenty-nine patients received either 4 g intravenous infusion or 100 mg subconjunctival application of azlocillin 1-12 h before cataract extraction. After intravenous application the mean aqueous humor concentration of azlocillin was 4.4 micrograms/ml after 3 h. The subconjunctival dose produced a mean aqueous humor concentration of 78 micrograms/ml and 3.4 micrograms/ml after 3 and 12 h, respectively. These levels are above the minimum inhibitory concentration of azlocillin for sensitive organisms.
D001082:Aqueous Humor / Q000032:analysis*; D001390:Azlocillin; D002387:Cataract Extraction / Q000379:methods*; D003228:Conjunctiva; D005260:Female; D006801:Humans; D007267:Injections; D007275:Injections, Intravenous; D008297:Male; D010406:Penicillins / Q000032:analysis*
D010406:Penicillins; D001390:Azlocillin