[Role of photoperiodicity and circadian rhythm of glucocorticoids in synchronizing the fluctuations in free-radical oxidation of lipids in rats].
A biphasic circadian rhythm in the content of liver lipid peroxidation products has been demonstrated in male Wistar rats housed under the conditions of 12L: 12D, with 3 hours of morning and evening twilight. Maxima of the concentration of the products were observed in the morning and early at night. The rhythm of lipid anti-oxidative activity was found in an anti-phase. Inversion of both the L: D cycle and glucocorticoid circadian rhythms (cortisol injections) led after 14-16 days to the same shifts in the rhythm of anti-oxidative activity. The data indicate that glucocorticoids modulate the diurnal rhythms of lipid anti-oxidative activity and may be responsible for the shifts in the rhythms of free radical oxidation, induced by inversion of the L: D cycle.
D015062:11-Hydroxycorticosteroids / Q000502:physiology*; D000818:Animals; D002940:Circadian Rhythm; D005260:Female; D005609:Free Radicals; D008027:Light; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D015062:11-Hydroxycorticosteroids; D005609:Free Radicals; D008054:Lipid Peroxides
Rol' fotoperiodiki i sutochnogo ritma gliukokortikoidov v sinkhronizatsii kolebaniĭ svobodnoradikal'nogo okisleniia lipidov u krys.