Fatal hepatitis after treatment with isoniazid and rifampicin in a patient on anticonvulsant therapy.
A 58-year-old man with a history of tuberculosis had been treated with anticonvulsant drugs for a long period and presented with a small lesion in the apex of the left lung. Prior to thoracotomy treatment with isoniazid and rifampicin was started. Fulminant hepatitis developed and the patient died on the 7th postoperative day, 9 days after starting the drugs. The risk of hepatotoxicity from isoniazid is increased when it is given concomitantly with anticonvulsants, halothane or rifampicin, all of which induce microsomal enzymes.
D000927:Anticonvulsants / Q000627:therapeutic use*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000009:adverse effects*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy
D000927:Anticonvulsants; D007538:Isoniazid; D012293:Rifampin