[Effect of dose magnitude and fractionation on the radiation damage to bone marrow cells forming granulocyte-macrophage colonies in diffusion chambers].
The ability of CFUdc to repair radiation-induced lesions in the irradiated body was studied by the methods of dose fractionation and dose-rate reduction. With the dose-rate decreased from 1-0.5 Gy/min to 0.02 Gy/min, a mean lethal dose per cell increased from 1.35 up to 1.93 Gy. With fractionation of the dose, the known picture of repair of sublethal radiation lesions was obtained the second survival peak being insignificant. The authors discuss the possible causes of the distinctions in the repair parameters of CFUdc obtained by the two methods.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006412:Hematopoietic Stem Cells / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008851:Micropore Filters
Vliianie moshchnosti i fraktsionirovaniia dozy na radiatsionnoe povrezhdenie kletok kostnogo mozga, formiruiushchikh granulotsitarno-makrofagal'nye kolonii v diffuzionnykh kamerakh.