Ritodrine hydrochloride infusion in pregnant baboons. II. Sodium and water compartment alterations.
To evaluate the effects of intravenously administered ritodrine hydrochloride on sodium and water metabolism, a pregnant baboon model was studied. Animals given ritodrine retained significantly more sodium (p less than 0.001) and administered fluids (p less than 0.002) compared with control animals. Although plasma volume did not change significantly within or between the two groups, extracellular volume increased by a mean of 1,480 ml in those given ritodrine compared with 790 ml in the control animals. There was no significant difference between animals given ritodrine and their controls regarding serial hematocrits, serum sodium, or colloid oncotic pressures. From this we conclude that the retained sodium and water was in the interstitial space. Since plasma volume was unaltered by ritodrine administration it seems unlikely that pure volume overload can explain the pulmonary edema induced by beta-mimetics. Combined with the prior observation that direct pulmonary capillary membrane toxicity does not occur, the likely pathophysiology of beta-agonist-induced pulmonary edema involves left ventricular failure.
D000818:Animals; D001825:Body Fluid Compartments / Q000187:drug effects*; D001826:Body Fluids / Q000187:drug effects*; D002199:Capillary Permeability / Q000187:drug effects; D005110:Extracellular Space / Q000378:metabolism; D005260:Female; D007263:Infusions, Parenteral; D010215:Papio; D010953:Plasma Volume / Q000187:drug effects; D011188:Potassium / Q000378:metabolism; D011247:Pregnancy; D011270:Pregnancy, Animal; D011412:Propanolamines / Q000494:pharmacology*; D011654:Pulmonary Edema / Q000139:chemically induced / Q000503:physiopathology; D012312:Ritodrine / Q000494:pharmacology*; D012964:Sodium / Q000378:metabolism*; D014882:Water-Electrolyte Balance / Q000187:drug effects
D011412:Propanolamines; D012964:Sodium; D012312:Ritodrine; D011188:Potassium