Comparison of 2- and 3-18F-fluoro-deoxy-D-glucose for studies of tissue metabolism.
2- and 3-18F-fluoro-deoxy-D-glucose were proposed as sugar analogs to study glucose metabolism in brain and heart tissues. To evaluate their usefulness, the in vivo behavior of 2- 28FDG and 3-18FDG was investigated in mice and rats and for 3-18FDG in dogs at various times post-injection. Positron emission tomographic (PET) imaging was performed for heart and brain of anesthetized dogs with both radiopharmaceuticals. In all species studied, a higher uptake in brain, heart and kidney was observed for 2-18FDG compared with 3-18FDG. Radioactivity also cleared blood and liver more rapidly with 2-18FDG than with 3-18FDG. Estimates of brain kinetic model parameters revealed the metabolic trapping of 2-18FDG, making this agent favorable for studies of tissue metabolism, and the relative lack of phosphorylation of 3-18FDG, which makes it a potential agent for studies of glucose transport.
D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000378:metabolism*; D004285:Dogs; D005461:Fluorine; D019788:Fluorodeoxyglucose F18; D006321:Heart / Q000000981:diagnostic imaging; D051379:Mice; D011868:Radioisotopes; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014055:Tomography, Emission-Computed
D003837:Deoxy Sugars; D011868:Radioisotopes; D019788:Fluorodeoxyglucose F18; C007253:3-deoxy-3-fluoro-D-glucose; D005461:Fluorine; D003847:Deoxyglucose