Steady state disposition of chloroquine in patients with rheumatoid disease.
The steady state disposition of chloroquine and its major metabolites, monodesethyl and bidesethyl chloroquine, were determined in 6 patients on long-term treatment for rheumatic disease with 99-155 mg base/day. The total body clearance of chloroquine was 0.35 l/kg/h and that of its metabolites was much higher. The renal clearance was the same for all compounds measured, approximately equal to 0.1 l/kg/h. Currently recommended dosage schedules appear to be too high in certain cases.
D000368:Aged; D001711:Biotransformation; D002738:Chloroquine / Q000378:metabolism* / Q000652:urine; D003404:Creatinine / Q000097:blood; D005260:Female; D006801:Humans; D008875:Middle Aged; D012216:Rheumatic Diseases / Q000378:metabolism*
D002738:Chloroquine; D003404:Creatinine