title: Influence of oxalate on the rate of the tricarboxylic acid cycle in rat hepatocytes.
abstract: In hepatocytes isolated from fed rats, physiological concentrations of oxalate lower the flux through the tricarboxylic acid cycle (-48%) and reduce the steady-state levels of oxaloacetate and other Krebs cycle intermediates. All the metabolic modifications observed are explained by pyruvate carboxylase inhibition, since oxalate hardly modifies the flux through pyruvate dehydrogenase.
mesh_terms: D000818:Animals; D002952:Citric Acid Cycle / Q000187:drug effects*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D010070:Oxalates / Q000494:pharmacology*; D019815:Oxalic Acid; D011766:Pyruvate Carboxylase / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010070:Oxalates; D019815:Oxalic Acid; D011766:Pyruvate Carboxylase