Effect of parenteral iron on serum electrolytes of the baby pig.
Twenty-eight 4-d-old nursing pigs were used in two trials to evaluate the effects of im injection of iron (Fe) from Fe-dextran upon subsequent serum mineral concentrations. An im injection of 150 mg of Fe from Fe-dextran was given to all pigs (n = 17) in trial 1. Serum Fe concentration increased rapidly from an initial mean of 65 to 3,466 micrograms/dl at 6 h postinjection (PI), 5,712 micrograms/dl at 24 h PI, then fell to 317 micrograms/dl at 4 d PI, 143 micrograms/dl at 7 d PI and remained about 100 micrograms/dl at 14, 21 and 28 d PI. Concentrations of other serum minerals did not appear to be influenced by the Fe-dextran injection. Treatments of Pigs (n = 11) in trial 2 were no injection, injection of dextran only, injection of 100 mg Fe from Fe-dextran and injection of 200 mg Fe from Fe-dextran. Serum Fe concentration increased rapidly after Fe-dextran injection, rising to a peak of 11,028 micrograms/dl at 6 h PI from the 100-mg Fe injection and 17,012 micrograms/dl at 6 h PI from the 200-mg Fe injection. Serum Fe concentration dropped steadily in pigs that were given no injection or injected with dextran only. Seven days after trial 2 started, all pigs that had received no injection or dextran only were injected with 100 mg Fe from Fe-dextran.(ABSTRACT TRUNCATED AT 250 WORDS)
D000818:Animals; D000833:Animals, Suckling; D001835:Body Weight; D002118:Calcium / Q000097:blood; D003300:Copper / Q000097:blood; D004573:Electrolytes / Q000097:blood*; D006400:Hematocrit / Q000662:veterinary; D006454:Hemoglobins / Q000032:analysis; D007273:Injections, Intramuscular / Q000662:veterinary; D007501:Iron / Q000097:blood; D007505:Iron-Dextran Complex / Q000008:administration & dosage / Q000494:pharmacology*; D008274:Magnesium / Q000097:blood; D010758:Phosphorus / Q000097:blood; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D013552:Swine / Q000097:blood*; D015032:Zinc / Q000097:blood
D004573:Electrolytes; D006454:Hemoglobins; D010758:Phosphorus; D003300:Copper; D007505:Iron-Dextran Complex; D012964:Sodium; D007501:Iron; D008274:Magnesium; D015032:Zinc; D011188:Potassium; D002118:Calcium