title: Benzoquinolinediones: activity as insect teratogens.
abstract: Morphological abnormalities including extra compound eyes, extra heads, and distally duplicated legs were generated in cricket embryos by treating eggs with single doses of either benz[g]isoquinoline-5,10-dione or benzo[h]quinoline-5,6-dione. Slight structural modifications of the molecules resulted in a loss of teratogenic activity, although embryotoxicity occurred. These potent insect teratogens can be used for analysis of developmental events during embryogenesis.
mesh_terms: D000818:Animals; D007546:Isoquinolines / Q000633:toxicity*; D009987:Orthoptera / Q000196:embryology*; D011804:Quinolines / Q000633:toxicity*; D015363:Quinolones; D013329:Structure-Activity Relationship; D013723:Teratogens
chemical_list: D007546:Isoquinolines; D011804:Quinolines; D015363:Quinolones; D013723:Teratogens; C039388:benzo(g)isoquinoline-5,10-dione; C039389:benzo(h)quinoline-5,6-dione