Molecular characterization of interleukin 2.
The isolation of specific T cell growth factors termed interleukin 2 (IL 2) is changing the approach to understanding T cell function. This class of growth factors has allowed te establishment of a number of human and murine T cell lines. We summarize the biochemical properties of human and murine IL 2. Studies have been initiated to isolate mRNA encoding for IL 2. Such RNA can be translated in rabbit reticulocyte lysates yielding IL. 2. This RNA may be useful for the development of probes to isolate lymphokine genes.
D000818:Animals; D006027:Glycosides / Q000032:analysis; D006801:Humans; D007376:Interleukin-2 / Q000235:genetics / Q000302:isolation & purification*; D007700:Kinetics; D008213:Lymphocyte Activation; D051379:Mice; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D011817:Rabbits; D012156:Reticulocytes / Q000378:metabolism; D013045:Species Specificity; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D006027:Glycosides; D007376:Interleukin-2; D012333:RNA, Messenger