Soluble glutathione S-transferase isoenzymes in rat brain.
The soluble glutathione S-transferase (GST) isoenzymes in rat brain were investigated using 1-chloro-2,4-dinitrobenzene (CDNB) as the second substrate. The percentages of the different CDNB-GST isoenzymes found were: anionic GST: 3.7%, GST D + E: 35.3%, GST C: 27.9%, GST B: 0.5%, GST A: 13.9% and GST AA: 18.6%. The percentages of isoenzymes are quite different from those measured in liver, testis and prostate. An important detoxication role of GST in brain is suggested.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D005982:Glutathione Transferase / Q000032:analysis*; D007527:Isoenzymes / Q000032:analysis*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012995:Solubility
D007527:Isoenzymes; D005982:Glutathione Transferase