title: Gastroesophageal fundoplication improves symptoms in refractory asthma.
abstract: Gastroesophageal (GE) reflux has been etiologically linked to a number of pulmonary diseases. Subclinical pulmonary aspiration from nocturnal GE reflux has been proposed as a cause of asthma. A patient with severe asthma, refractory to conventional medical therapy, is presented. The asthma was presumed to be secondary to gastroesophageal reflux and indeed the patient became asymptomatic following a Nissen fundoplication procedure. This case report documents that surgical correction of GE reflux may be an appropriate therapeutic maneuver in asthmatics who subclinically aspirate as a consequence of GE reflux.
mesh_terms: D000328:Adult; D001249:Asthma / Q000209:etiology / Q000628:therapy*; D001986:Bronchial Spasm / Q000150:complications; D004942:Esophagitis, Peptic / Q000150:complications / Q000601:surgery*; D004947:Esophagus / Q000601:surgery*; D005260:Female; D005748:Gastric Fundus / Q000601:surgery*; D006801:Humans