Effect of dietary level of Vitamin E on the immune system of the spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rat.
Spontaneously hypertensive rats (SHR) had depressed splenic mitogen responses as well as lower splenic vitamin E when compared to normotensive Wistar Kyoto strain (WKY) rats fed a stock diet. Both strains had depressed T- and B-cell splenic mitogen responses after 17 weeks on a semipurified, vitamin E-deficient diet when compared to animals fed either stock or dl-alpha-tocopheryl acetate-supplemented semipurified diet. In addition, SHR fed the vitamin E-supplemented diet had enhanced thymocyte rosetting compared to those fed the vitamin E-deficient diet. In contrast, the dietary vitamin E level did not affect the thymocyte rosetting in WKY rats.
D000818:Animals; D004032:Diet; D006973:Hypertension / Q000276:immunology*; D007111:Immunity, Cellular; D008297:Male; D008934:Mitogens / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012397:Rosette Formation; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014810:Vitamin E / Q000008:administration & dosage*
D008934:Mitogens; D014810:Vitamin E