Immunological and cytogenetic studies in two cases of B-cell acute lymphoblastic leukemia (Burkitt's type).
Immunological and cytogenetic studies were performed on two patients who presented with L-3 acute lymphocytic leukemia (Burkitt-type). Surface marker studies showed that both had B-cell leukemias. The blast cells in Case 1 expressed monoclonal IgM kappa surface immunoglobulin and in Case 2, IgG kappa. In the first case, cytogenetic analysis of bone marrow revealed the presence of a rare variant translocation involving the short arm of chromosome 2 and the long arm of chromosome 8 in all the metaphases examined. This is the second report of such a translocation in Burkitt's leukemia. The 8;14 translocation reported in classical Burkitt's lymphoma and other B-cell lymphomas was present in all the bone marrow metaphases in the second case.
D000328:Adult; D000954:Antigens, Surface / Q000032:analysis; D002051:Burkitt Lymphoma / Q000235:genetics* / Q000276:immunology; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002900:Chromosomes, Human, 1-3; D002906:Chromosomes, Human, 6-12 and X; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D014178:Translocation, Genetic; D014314:Trisomy
D000954:Antigens, Surface