Effects of quinuronium sulfate pre-exposure on hepatic excretion of sulfobromophthalein (BSP) as measured by isolated perfused rat liver.
Effects of quinuronium sulphate pre-exposure on hepatic excretion of sulfobromophthalein (BSP) as measured by isolated perfused rat liver was investigated. Seventeen rats were used in the study. Rats were divided into controls (Group 1, n = 5), low quinuronium treated animals (Group 2, n = 6), and high quinuronium treated animals (Group 3, n = 6) receiving 0, 1.5 or 2.3 mg quinuronium sulphate/kg intraperitoneally, respectively. Each animal was dosed 30 min. before sacrifice. After 30 min. of equilibrium perfusion, BSP was introduced and the experiment continued for 2 hours. Perfusate and bile were collected at designated time intervals and the volume of bile was noted. BSP in perfusate and bile was assayed. Half-life in minutes (t 1/2 +/- S.E.) of BSP disappearance from perfusate in groups 1, 2 and 3 were 12.5 +/- 1.8, 13.7 +/- 1.0 and 16.8 +/- 3.3, respectively. Group 2 and 3 rats had a significant decrease of BSP excretion in bile (P less than 0.01) compared to group 1 rats. Bile volumes decreased in both quinuronium pre-exposed groups of rats compared to control rats. These observations indicate that quinuronium affects liver function.
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D001646:Bile / Q000378:metabolism; D006207:Half-Life; D008099:Liver / Q000378:metabolism*; D008111:Liver Function Tests; D008297:Male; D010477:Perfusion; D011806:Quinolinium Compounds / Q000494:pharmacology*; D051381:Rats; D013448:Sulfobromophthalein / Q000378:metabolism*; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology
D000981:Antiprotozoal Agents; D011806:Quinolinium Compounds; D013448:Sulfobromophthalein; D014508:Urea; C009154:quinuronium sulfate