Studies of the kallikrein-kinin system in patients with sickle cell anemia.
Eight patients with sickle cell anemia (SS hemoglobin) were found to have decreased plasma levels of prekallikrein compared to normal control subjects or patients with other types of anemia. The prekallikrein levels in the patients with sickle cell anemia were found to decrease further during a sickle cell crisis. These results suggest that components of the kallikrein-kinin system are profoundly affected in patients with sickle cell anemia, and during crises may play a role in the clinical presentation of patients.
D000293:Adolescent; D000328:Adult; D000740:Anemia / Q000097:blood / Q000378:metabolism; D000755:Anemia, Sickle Cell / Q000097:blood*; D001920:Bradykinin / Q000097:blood*; D005174:Factor XII / Q000097:blood*; D015956:Factor XIIa; D005260:Female; D006801:Humans; D007610:Kallikreins / Q000097:blood*; D007705:Kinins / Q000378:metabolism; D008297:Male; D010446:Peptide Fragments / Q000097:blood*; D011288:Prekallikrein / Q000032:analysis / Q000378:metabolism; D012075:Remission, Spontaneous
D007705:Kinins; D010446:Peptide Fragments; D005174:Factor XII; D011288:Prekallikrein; D007610:Kallikreins; D015956:Factor XIIa; D001920:Bradykinin