Antagonism by tomoxetine of the depletion of norepinephrine and epinephrine in rat brain by alpha-methyl-m-tyrosine.
Tomoxetine hydrochloride, a potential antidepressant drug, antagonized the alpha-methyl-m-tyrosine-induced depletion of hypothalamic epinephrine and norepinephrine in rats. The findings suggest that tomoxetine, like several uptake-inhibiting antidepressant drugs that have been examined, inhibits uptake into epinephrine neurons as well as norepinephrine neurons in brain.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D004837:Epinephrine / Q000378:metabolism*; D005473:Fluoxetine / Q000031:analogs & derivatives / Q000494:pharmacology*; D008297:Male; D008781:Methyltyrosines / Q000037:antagonists & inhibitors*; D009638:Norepinephrine / Q000378:metabolism*; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats
D000928:Antidepressive Agents; D008781:Methyltyrosines; D011437:Propylamines; D005473:Fluoxetine; C011386:nisoxetine; D009638:Norepinephrine; D004837:Epinephrine