Hymenolepis nana: maturation in an immunosuppressed unnatural rat host.
When eggs of the dwarf tapeworm Hymenolepis nana, cycled exclusively and directly through mice for more than 10 years, were inoculated into previously uninfected inbred Fischer (F344) strain rats, they failed to mature in the rat intestinal lumen. Eggs of H. nana inoculated into the rat developed normally into cysticercoids (cysts) in the intestinal tissue, but thereafter failed to mature in the lumen except when the host was treated with cortisone acetate from the day of cyst maturation. The Fischer rat initially given eggs of H. nana became completely immune to egg challenge within 2 days of egg inoculation; no cysts derived from challenge eggs were found in the immunized rat. Immunosuppression, assessed by the success of cyst recovery in the tissue 4 days after egg challenge, had no promotive effect on the recovery of adult worms derived from eggs initially inoculated. Rats initially given eggs and immunosuppressed by cyclophosphamide or antithymocyte serum did not harbor any adult worms. Cortisone acetate treatment which was sufficient for eggs inoculated to mature (a total of 75 or even 200 mg, from Day 5 of egg inoculation) had no effects of immunosuppression, whereas cortisone acetate treatment which was sufficient for immunosuppression (a total of 150 mg from Day -2, two days prior to the initial egg inoculation) induced some adult formation as well. In addition, when mouse-derived cysts were inoculated into the rat instead of eggs, they also failed completely to mature even when the rat was treated with cyclophosphamide or antithymocyte serum.(ABSTRACT TRUNCATED AT 250 WORDS)
D000818:Animals; D000961:Antilymphocyte Serum / Q000494:pharmacology; D003348:Cortisone / Q000031:analogs & derivatives / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology; D004198:Disease Susceptibility; D005260:Female; D006925:Hymenolepiasis / Q000276:immunology / Q000469:parasitology*; D006926:Hymenolepis / Q000254:growth & development*; D007108:Immune Tolerance; D007110:Immunity, Active; D007113:Immunity, Innate; D007422:Intestines / Q000469:parasitology; D008297:Male; D010063:Ovum / Q000502:physiology; D051381:Rats; D011916:Rats, Inbred F344; D013601:T-Lymphocytes / Q000276:immunology
D000961:Antilymphocyte Serum; D003520:Cyclophosphamide; D003348:Cortisone