Lack of synergy between T and B cells in the response to 2-mercaptoethanol in old NZB/W F1 mice.
The responses of NZB X NZW (NZB/W) F1 mice to 2-mercaptoethanol (2-ME) were examined from the viewpoint of T-B cell interaction. Young (1-month-old NZB/W F1 mice responded to 2-ME in an almost similar pattern to that of BALB/c mice, although a slightly higher rate of DNA synthesis was observed in B cell-enriched cultures (75% B cells) containing 2-ME than in those of BALB/c mice. Old (9-mth-old) NZB/W F1 mice showed an absent synergistic effect of T and B cells in the response to 2-ME. These results indicate an abnormality of T-B cell interaction particularly in old NZB/W F1 mice.
D000818:Animals; D001323:Autoantibodies; D001402:B-Lymphocytes / Q000276:immunology*; D005260:Female; D066298:In Vitro Techniques; D008213:Lymphocyte Activation / Q000187:drug effects; D008211:Lymphocyte Cooperation; D008623:Mercaptoethanol / Q000494:pharmacology*; D051379:Mice; D013154:Spleen / Q000187:drug effects; D013601:T-Lymphocytes / Q000276:immunology*
D001323:Autoantibodies; D008623:Mercaptoethanol