Paracellular absorption of D-glucose by rat small intestine in vivo.
D-glucose diffusion in both jejunum and ileum using a perfusion system in vivo was determined. 2,4,6-triaminopyrimidine (20 mM) induced an inhibition on D-glucose diffusion of 32% in the two segments of the small intestine studied. Glucose net efflux from the jejunum into the lumen was higher than that from the ileum. Phlorizin increased the sugar efflux in both areas.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D005110:Extracellular Space / Q000378:metabolism; D005947:Glucose / Q000378:metabolism*; D007082:Ileum / Q000378:metabolism*; D007408:Intestinal Absorption / Q000187:drug effects; D007583:Jejunum / Q000378:metabolism*; D010477:Perfusion; D010695:Phlorhizin / Q000494:pharmacology; D011743:Pyrimidines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D011743:Pyrimidines; C012070:2,4,6-triaminopyrimidine; D010695:Phlorhizin; D005947:Glucose