Increased myeloid colony growth in vitro of precultured progenitor cells.
Human peripheral blood myeloid progenitor cells (GM-CFU) form markedly more colonies in soft agar following a short-term preculture in vitro. This enhancement is independent of monocytes and T lymphocytes and reflects an alteration of progenitor cells themselves. The preculture increases the number of cells being in the S phase of cell cycle and renders them relatively independent of exogenous CSF.
D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D006098:Granulocytes / Q000502:physiology; D006410:Hematopoiesis; D006801:Humans; D008264:Macrophages / Q000502:physiology; D013601:T-Lymphocytes / Q000502:physiology