Kinetics of tissue distribution and elimination of 4,4'-methylene bis(2-chloroaniline) in rats.
The tissue distribution kinetics and elimination of 4,4'-methylene bis(2-chloroaniline) (MBOCA) in rats was studied after a single dose of [14C]MBOCA (0.49 mg/kg body weight, i.v.). The highest concentrations of radioactivity were in the small intestine, liver, adipose, lung, kidney, skin, and adrenals. For most tissues, a rapid decrease in radioactivity was followed by a slower decrease except for the small intestine, adipose and skin which demonstrated transient increases. Subcellular distribution in liver at 1 h showed radioactivity in all cell fractions. Although very lipophilic, [14C]MBOCA was completely eliminated within 48 h with the major route via the feces (73.4%).
D000273:Adipose Tissue / Q000378:metabolism; D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001559:Benzhydryl Compounds / Q000378:metabolism*; D002250:Carbon Radioisotopes; D005243:Feces / Q000032:analysis; D005260:Female; D007421:Intestine, Small / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008753:Methylenebis(chloroaniline) / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000378:metabolism; D014018:Tissue Distribution
D001559:Benzhydryl Compounds; D002250:Carbon Radioisotopes; D008753:Methylenebis(chloroaniline)