title: Angiotensinogen is related to the antitrypsin-antithrombin-ovalbumin family.
abstract: The recently reported amino acid sequence of rat angiotensinogen was subjected to a computer-assisted search for homology with known sequences stored in a data bank and found to be significantly related to that of plasma alpha 1-antitrypsin, itself a member of a family that includes antithrombin III and ovalbumin. An alignment of the four sequences shows indisputably the common ancestry of all four proteins.
mesh_terms: D000595:Amino Acid Sequence; D000808:Angiotensinogen / Q000235:genetics*; D000809:Angiotensins / Q000235:genetics*; D000818:Animals; D000991:Antithrombins / Q000235:genetics; D005075:Biological Evolution; D046911:Macromolecular Substances; D010047:Ovalbumin / Q000235:genetics; D051381:Rats; D000515:alpha 1-Antitrypsin / Q000235:genetics
chemical_list: D000809:Angiotensins; D000991:Antithrombins; D046911:Macromolecular Substances; D000515:alpha 1-Antitrypsin; D000808:Angiotensinogen; D010047:Ovalbumin