title: [Diet and chronic renal failure].
abstract: In the last 10 years the diet severely restricted in proteins advocated by GIORDANO and GIOVANNETTI in the treatment of chronic renal failure has fallen out of use because in the long term it induced cachectic states in most patients. In recent months, however, experimental studies have pointed to the negative effect protein intake may have on renal function. Glomerular hyperfiltration induced by protein intake may lead to proteinuria and glomerulosclerosis, which in turn aggravates impaired renal function and glomerular hyperfiltration. Some clinical studies appear to confirm the beneficial effect on the progression of renal failure when diets containing 15-30 g protein per day are instituted. This new approach may be of considerable practical importance but at present most of these studies need confirmation and generalized uncontrolled administration of diets severely restricted in proteins is not yet justified.
mesh_terms: D002136:Calcium, Dietary / Q000627:therapeutic use; D004039:Diet, Sodium-Restricted; D004041:Dietary Fats / Q000627:therapeutic use; D004044:Dietary Proteins / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007676:Kidney Failure, Chronic / Q000178:diet therapy / Q000209:etiology*; D010758:Phosphorus / Q000627:therapeutic use; D012964:Sodium
chemical_list: D002136:Calcium, Dietary; D004041:Dietary Fats; D004044:Dietary Proteins; D010758:Phosphorus; D012964:Sodium
vernacular_title: Régime et insuffisance rénale chronique.