Studies on IgE production in mice. I. Spontaneous suppression of IgE production in SJA/9 mice.
IgE levels after Nippostrongylus brasiliensis infestation were high in all strains of mice examined except in the SJA/9 strain. However, surface IgE levels on B cells were not different from those observed in the SJL strain. Most surface IgE-bearing cells also had surface IgM molecules. We suggest that the surface IgE-bearing cells are precursors of IgE-producing cells. In adoptive transfer, hapten-specific IgE antibody was produced when hapten-primed cells from SJA/9 mice were transferred together with cells from SJL donors infested with N. brasiliensis but not when the cells were from SJA/9 donors. It is suggested that the lack of collaboration between hapten-primed B cells and cells from infested mice is a genetic trait of the SJA/9 strain.
D000818:Animals; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D003433:Crosses, Genetic; D006725:Hookworm Infections / Q000276:immunology; D007073:Immunoglobulin E / Q000032:analysis / Q000235:genetics*; D007165:Immunosuppression Therapy; D051379:Mice; D008817:Mice, Mutant Strains; D009559:Nippostrongylus; D013045:Species Specificity
D007073:Immunoglobulin E