Preliminary report: the effects of acute acidosis on alanine and glucose metabolism across the liver, gut, kidney, and muscle in the dog.
Acute metabolic acidosis (AMA) in the dog results in a 48% increase in arterial alanine concentration and an 11% fall in blood glucose. Extraction/production of glucose and alanine were studied by A/V sampling and electromagnetic blood flow probe measurements. Alanine and total amino-N release by muscle increased in acidosis Hepatic glucose release was reduced. More marked changes in metabolism occur in AMA in the dog than previously considered.
D000138:Acidosis / Q000378:metabolism*; D000208:Acute Disease; D000409:Alanine / Q000097:blood / Q000378:metabolism*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004064:Digestive System / Q000378:metabolism; D004285:Dogs; D005947:Glucose / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009132:Muscles / Q000378:metabolism
D001786:Blood Glucose; D005947:Glucose; D000409:Alanine