Duchenne muscular dystrophy: alterations in lymphocyte fluidity.
We have studied lymphocyte membrane from 7 patients with Duchenne Muscular Dystrophy (DMD) and 8 normal controls using fluorescence polarization of 1,6-diphenyl-hexatriene (DPH). The microviscosity of lymphocytes membrane is significatively higher in DMD patients than in normal controls. Our results support the hypothesis of a generalized membrane defect in Duchenne Muscular Dystrophy.
D055598:Chemical Phenomena; D002621:Chemistry; D004161:Diphenylhexatriene; D005454:Fluorescence Polarization; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure*; D008560:Membrane Fluidity; D009136:Muscular Dystrophies / Q000097:blood*
D004161:Diphenylhexatriene