title: Deposition of immune complexes in the mouse eye.
abstract: The ocular deposition of circulating immune complexes was studied in mice using passive and active immune complex models. In the passive model, immune complexes were made at different antigen-to-antibody ratios and subsequently injected intravenously. In the active model, antigen alone was injected intravenously into immune mice. Ocular localization was studied by immunofluorescence microscopy. In both experimental models a marked deposition of antigen, antibody and mouse C3 could be observed in the scleral capillary area, whereas a weaker deposition could also be observed in the ciliary body, iris and choroid. With the immune complex doses used, only a short (1-2 hr) ocular deposition was observed and no inflammatory signs were seen upon histological examination. The deposition of complexes in the episcleral capillary area could provide a suitable experimental model to analyse the role of circulating immune complexes in the pathogenesis of scleral phenomena associated with rheumatoid arthritis.
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis*; D002196:Capillaries; D002829:Choroid / Q000276:immunology; D002924:Ciliary Body / Q000276:immunology; D003315:Cornea / Q000276:immunology; D005123:Eye / Q000276:immunology*; D007116:Immunization, Passive; D007498:Iris / Q000276:immunology; D051379:Mice; D008856:Microscopy, Fluorescence; D012590:Sclera / Q000098:blood supply / Q000276:immunology
chemical_list: D000936:Antigen-Antibody Complex