Studies on the blood of an MsHe/MSu proposita and her family. Serological evidence that Henshaw-producing genes do not code for the 'N' antigen.
The serum of a black woman has been found to contain a potent alloanti-N that reacted in direct agglutination tests with the 'N' antigen carried on Ss-active sialoglycoprotein. Thus far, such antibodies have been observed only in the sera of MSu/MSu individuals. However, our proposita had red cells that lacked 'N'. Her blood type was M+, N-, S-, s+, U+, He+. Results of family studies indicate that she is of the genotype MsHe/MSu. Our findings are consistent with recently reported data on the structure of the Henshaw antigen, which is located on a Ss-active sialoglycoprotein that does not carry 'N'.
D001787:Blood Group Incompatibility / Q000097:blood / Q000209:etiology / Q000235:genetics; D005260:Female; D005815:Genetic Code; D005838:Genotype; D006021:Glycophorins / Q000235:genetics*; D006801:Humans; D007518:Isoantibodies / Q000032:analysis*; D008951:MNSs Blood-Group System / Q000235:genetics* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012795:Sialoglycoproteins / Q000235:genetics*
D006021:Glycophorins; D007518:Isoantibodies; D008951:MNSs Blood-Group System; D012795:Sialoglycoproteins