Generation of lytic and proliferative lymphoid clones to syngeneic tumor: in vitro and in vivo studies.
T-cell clones that exhibited both lytic and proliferative activity for the syngeneic FBL-3 lymphoma were isolated from in vitro sensitization cultures. These clones were Lyt-2+ and proliferated specifically to the FBL-3 lymphoma but not to other tumors of C57BL/6 origin, allogeneic tumor, or C57BL/6 normal lymphocytes. Adoptive transfer of clones exhibiting both proliferative and cytotoxic activity prolonged survival and occasionally cured the animals of disseminated FBL-3 lymphomas, while T-cell clones exhibiting lytic but no proliferative activity conferred no survival benefit compared to the survival seen among animals receiving no treatment.
D000818:Animals; D002455:Cell Division; D002460:Cell Line; D002999:Clone Cells / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D005260:Female; D005622:Friend murine leukemia virus; D007116:Immunization, Passive; D066298:In Vitro Techniques; D007942:Leukemia, Experimental / Q000276:immunology* / Q000628:therapy; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology