title: Vitamin K-dependent proteins and anticonvulsant medication.
abstract: Certain anticonvulsant drugs, especially phenytoin and phenobarbital, interfere with vitamin K metabolism as indicated by a raised serum osteocalcin level. This finding may be of importance in the pathogenesis of side effects of these medications.
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging; D000927:Anticonvulsants / Q000494:pharmacology* / Q000627:therapeutic use; D002135:Calcium-Binding Proteins / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin; D010634:Phenobarbital / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology; D012640:Seizures / Q000188:drug therapy; D014812:Vitamin K / Q000378:metabolism*
chemical_list: D000927:Anticonvulsants; D002135:Calcium-Binding Proteins; D015675:Osteocalcin; D014812:Vitamin K; D010672:Phenytoin; D010634:Phenobarbital