Prevention of experimental allergic encephalitis with in vivo administration of anti I-A antibody. Decreased accumulation of radiolabelled lymph node cells in the central nervous system.
Experimental allergic encephalitis (EAE) can be prevented with the in vivo administration of monoclonal anti I-A antibody. A radiometric assay was developed to measure the accumulation of lymphocytes in the central nervous system of EAE animals. A direct correlation was observed between severity of clinical disease and the amount of radiolabelled lymph node cells (LNC) in the central nervous system. Injection of anti I-A antibody in vivo prevented clinical EAE and decreased the accumulation of radiolabelled LNC in spinal cord after immunization with mouse spinal cord homogenate and adjuvants.
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D001921:Brain / Q000276:immunology; D001927:Brain Diseases / Q000276:immunology; D002860:Chromium Radioisotopes; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology / Q000517:prevention & control*; D005260:Female; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D007114:Immunization; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D013116:Spinal Cord / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D002860:Chromium Radioisotopes; D000949:Histocompatibility Antigens Class II