[Mechanism of virus-induced immunopathology. I. The reactivity of immunocompetent cells in acute herpetic infection in an experiment].
The state of general and specific responsiveness of thymocytes and splenocytes in non-inbred white mice has been studied in the reaction of lymphocyte blast transformation under the influence of phytohemagglutinin (PHA) and herpes simplex virus. Experimental herpetic encephalitis has been shown to give rise to the development of pronounced immunosuppression, which is confirmed by a considerable decrease (P less than 0.05) in the levels of the PHA- and virus-induced transformation of thymocytes and splenocytes in infected mice in comparison with the similar transformation characteristics of intact lymphocytes. The inhibition of the general and specific responsiveness of T-lymphocytes has been found to be one of the possible mechanisms of immunosuppression in acute herpes infection.
D000208:Acute Disease; D000818:Animals; D006561:Herpes Simplex / Q000209:etiology / Q000276:immunology*; D007154:Immune System Diseases / Q000209:etiology*; D007108:Immune Tolerance; D007111:Immunity, Cellular; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D010835:Phytohemagglutinins / Q000494:pharmacology; D013154:Spleen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014777:Virus Diseases / Q000209:etiology*
D010835:Phytohemagglutinins
O mekhanizme virusindutsirovannoĭ immunopatologii. Soobshchenie I. Reaktivnost' immunokompetentnykh kletok pri ostroĭ gerpeticheskoĭ infektsii v éksperimente.