Hypotension following cimetidine administration during cardiopulmonary bypass.
Intravenous administration of cimetidine may occasionally cause profound hypotension. Cimetidine 200 mg was administered as a bolus injection to patients whilst on cardiopulmonary bypass and subsequent changes in systemic arterial pressure were recorded. A statistically significant fall in arterial pressure was observed (p less than 0.001), which was attributable to a fall in systemic vascular resistance.
D001794:Blood Pressure / Q000187:drug effects*; D002315:Cardiopulmonary Bypass; D002927:Cimetidine / Q000494:pharmacology*; D001026:Coronary Artery Bypass; D003864:Depression, Chemical; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D007432:Intraoperative Period; D008875:Middle Aged; D013997:Time Factors
D006146:Guanidines; D002927:Cimetidine