[Action of estradiol and progesterone on alkaline and acid phosphatase activity in the sheep uterus].
The effect was studied of 20 and 60 micrograms/kg body mass of estradiol and of the combination of 60 micrograms/kg estradiol and 1 mg/kg progesterone on the character and changes in the activity of alkaline and acid phosphatase in the endo- and myometrium of the uterus and the peripheral blood in sheep. The hormones were applied singly, i/m to 18 entire and castrated year-old female sheep. The enzyme in entire females treated with 60 micrograms/kg estradiol lowered its activity, while the enzyme in those treated with the combination raised it. The treatment of castrated females with estradiol at the rate of 60 micrograms/kg raised the activity of both alkaline and acid phosphatase in the endometrium. The activity of these enzymes in the myometrium of intact animals at estradiol and combined treatment dropped. It did not show a dependable rise in the myomentrium of castrated females when treated with both estradiol and estradiol and progesterone. Following treatment with 20 and 60 micrograms/kg body mass of estradiol with castrated, and with 60 micrograms/kg of estradiol with intacts the activity of both enzymes in the blood serum rose.
D000135:Acid Phosphatase / Q000378:metabolism*; D000469:Alkaline Phosphatase / Q000378:metabolism*; D000818:Animals; D002369:Castration; D004305:Dose-Response Relationship, Drug; D004717:Endometrium / Q000187:drug effects / Q000201:enzymology; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D009215:Myometrium / Q000187:drug effects / Q000201:enzymology; D011374:Progesterone / Q000494:pharmacology*; D012756:Sheep; D014599:Uterus / Q000187:drug effects* / Q000201:enzymology
D011374:Progesterone; D004958:Estradiol; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase
Deĭstvie na estradiola i progesterona vŭrkhu aktivnostta na alkalnata i kiselata fosfataza v matkata na ovtse.