H-Y antigen entrance into the immune system: relationship between lymphokine release, proliferation, cytotoxicity and delayed hypersensitivity.
In this paper we tested in parallel lymphokine release, proliferation, cytotoxicity and delayed hypersensitivity (DTH) reactions to H-7 antigen in high responder C57Bl/6 female mice. In vivo priming and in vitro restimulation are required in order to activate all the in vitro T-lymphocyte functions, and the ability to locally transfer DTH reactions. By contrast, a discrepancy is found between in vitro and in vivo tests of T-lymphocyte reactivity. In primed mice DTH reactions are evident, whereas no in vitro reactivity to H-Y is detectable.
D000818:Animals; D005260:Female; D006182:H-Y Antigen / Q000276:immunology*; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008213:Lymphocyte Activation; D008222:Lymphokines / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology*
D006182:H-Y Antigen; D008222:Lymphokines