Mycoplanecins, novel antimycobacterial antibiotics from Actinoplanes awajinensis subsp. mycoplanecinus subsp. nov. I. Taxonomy of producing organism and fermentation.
Strain No. 41042, an actinomycete isolated from a soil sample, was found to produce 5-azacytidine and new antibiotics, mycoplanecins. Yellowish brown to yellowish orange color of colonies on agar media, formation of globose to subglobose sporangia bearing motile spores and presence of meso- and hydroxy-diaminopimelic acid and glycine in the cell wall ascribed this strain to genus Actinoplanes. From its morphological, cultural and physiological characteristics, this strain was determined to be a new subspecies of Actinoplanes awajinensis and designated as A. awajinensis subsp. mycoplanecinus subsp. nov. Production of mycoplanecins was carried out by conventional submerged culture: the highest antibiotic titer obtained was 145 micrograms/ml.
D000192:Actinomycetales / Q000145:classification / Q000254:growth & development* / Q000648:ultrastructure; D000900:Anti-Bacterial Agents; D003470:Culture Media; D005285:Fermentation; D036341:Intercellular Signaling Peptides and Proteins; D008855:Microscopy, Electron, Scanning; D010455:Peptides / Q000302:isolation & purification
D000900:Anti-Bacterial Agents; D003470:Culture Media; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C039533:mycoplanecin A