title: Early action of nerve determines motor endplate differentiation in rat muscle.
abstract: The formation of a motor endplate is characterized by a complex series of changes in the properties of the subsynaptic acetylcholine receptors (AChRs). Among the last changes to occur are the shortening of the apparent mean open time of their ion channels from about 4 to 1 ms and an increase in the single-channel conductance. This conversion of channel gating at the endplate seems to be induced by the motor neurone. We report here that fast channel gating also develops at nerve-free endplate sites of fibres that had been denervated while gating was still slow. At such sites, junctional folds will develop in the absence of the nerve terminal. Although the conversion of channel gating and the formation of junctional folds are late events in endplate development, the neural signals inducing these changes must therefore act at the earliest stages of junctional development.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D007700:Kinetics; D008854:Microscopy, Electron; D009045:Motor Endplate / Q000502:physiology*; D009046:Motor Neurons / Q000502:physiology*; D009119:Muscle Contraction; D009469:Neuromuscular Junction / Q000502:physiology*; D051381:Rats; D011950:Receptors, Cholinergic / Q000502:physiology; D012508:Sarcolemma / Q000648:ultrastructure
chemical_list: D011950:Receptors, Cholinergic