title: Use of the cricket embryo (Acheta domesticus) as an invertebrate teratology model.
abstract: Embryos of the cricket Acheta domesticus (L.) have been shown by bioassay to develop gross morphological abnormalities after exposure to a number of complex organic mixtures as well as to display a critical period of teratogen sensitivity and an ability to metabolize xenobiotics during development. Because the assay is simple, inexpensive, short-term (less than two weeks), and objective, it could be useful as an in vivo screen in a hierarchical approach to teratogen detection. Further investigation of cricket embryo responses to known teratogens is needed to establish the predictive value of this assay.
mesh_terms: D000166:Acridines / Q000633:toxicity; D000375:Aging; D000818:Animals; D001711:Biotransformation; D007814:Larva / Q000187:drug effects; D009987:Orthoptera / Q000187:drug effects*; D013723:Teratogens / Q000378:metabolism; D014116:Toxicology / Q000379:methods*
chemical_list: D000166:Acridines; D013723:Teratogens