Plasma digoxin: assay anomalies in Fab-treated patients.
Using a variety of radioimmunoassay methods, plasma digoxin concentrations were measured in two patients before and after the administration of ovine Fab antibody fragments to remove the effects of digoxin. Gross method-dependent anomalies in the results due to in vitro drug interaction were observed. More widespread use of immunotherapy may invalidate data obtained by direct immunoassay techniques.
D004077:Digoxin / Q000097:blood* / Q000506:poisoning; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D008875:Middle Aged; D011863:Radioimmunoassay
D007140:Immunoglobulin Fab Fragments; D004077:Digoxin