Dialkylformamidines: depurination resistant N6-protecting group for deoxyadenosine.
Sterically hindered N6-dialkylformamidine protected deoxyadenosine is more stable to acidic depurination than N6-benzoyldeoxyadenosine and is potentially a valuable protecting group in the synthesis of deoxyoligonucleotides.
D000241:Adenosine / Q000031:analogs & derivatives; D000578:Amidines; D003839:Deoxyadenosines; D005559:Formamides; D007202:Indicators and Reagents; D007700:Kinetics; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis*; D009841:Oligonucleotides / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
D000578:Amidines; D003839:Deoxyadenosines; D005559:Formamides; D007202:Indicators and Reagents; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; C017061:N(6)-benzyladenosine; D000241:Adenosine