Cytofluorescence localization of adriamycin-binding sites of cardiac tissue.
A study of the cardiotoxicity induced by adriamycin (ADR) was done on the heart tissue of Sprague-Dawley rats receiving a single intravenous dose (15 mg/kg). Condensed bright orange-red fluoresced chromatin was observed in the nuclei of the myocardial cells of the left ventricle 2 h after drug injection. Just then, the intensity of the fluorescence emission started to decrease until it reached its minimum after 21 days, and disappeared completely 28 days after drug injection.
D000818:Animals; D001665:Binding Sites; D004317:Doxorubicin / Q000378:metabolism*; D008297:Male; D008856:Microscopy, Fluorescence; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004317:Doxorubicin