[Cardiostimulating action of liposome-incorporated noradrenaline during adrenergic-receptor block].
Norepinephrine (NE) contained in liposomes increased myocardial contractility and raised the blood pressure with no bradycardia or arrhythmia. NE exerted this cardiostimulating effect in condition of complete adrenoreceptor blockade. Separate infusion of NE and liposomes restored the sensitivity of the adrenergic structures in adrenergic blockade. Modified effect of liposome-entrapped NE depends on liposome effect upon the cell membrane and on concentration of NE in the blood.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002316:Cardiotonic Agents / Q000008:administration & dosage*; D002415:Cats; D004347:Drug Interactions; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D008081:Liposomes / Q000008:administration & dosage; D009200:Myocardial Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000008:administration & dosage*; D010646:Phentolamine / Q000008:administration & dosage; D011433:Propranolol / Q000008:administration & dosage; D014655:Vascular Resistance / Q000187:drug effects
D002316:Cardiotonic Agents; D008081:Liposomes; D011433:Propranolol; D009638:Norepinephrine; D010646:Phentolamine
Kardiostimuliruiushchee deĭstvie zakliuchennogo v liposomy noradrenalina v usloviiakh blokady adrenergicheskikh retseptorov.