New beta-lactam antibiotics, carpetimycins C and D.
Two new carbapenem antibiotics, carpetimycins C and D have been isolated from the culture broth of Streptomyces sp. KC-6643, which produced carpetimycins A and B. The structures of carpetimycins C and D have been determined to be (5R,6R)-3-[2-acetamidoethyl-(R)-sulfinyl]-6-(1-hydroxy-1-methylethyl) -7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid and (5R,6R)-3-[2-acetamidoethyl-(R)-sulfinyl]-6-(1-hydroxysulfonyloxy-1 -methylethyl)-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid, respectively. Studies on the fermentation, isolation and physico-chemical properties of these antibiotics are also described.
D001419:Bacteria / Q000187:drug effects; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D009904:Optical Rotation; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000254:growth & development; D013329:Structure-Activity Relationship; D013845:Thienamycins / Q000302:isolation & purification* / Q000633:toxicity
D013845:Thienamycins; C039530:carpetimycin C; C039531:carpetimycin D