The mode of action of chlorpromazine on mitochondrial membrane permeability to K+.
The effects of chlorpromazine on parameters related to potassium transport in isolated rat liver intact mitochondria were investigated. The results showed that chlorpromazine induced the passive permeability of mitochondrial membrane to potassium. A competition between spermine and chlorpromazine suggested the same binding sites within the inner mitochondrial membrane. Partial neutralization of mitochondrial surface potential by chlorpromazine indicated that this drug binds to negatively charged superficial sites of the membrane. A mechanism of action of chlorpromazine on potassium transport across the mitochondrial membrane involving alterations of surface potential and disarrangement of lipid bilayer is postulated.
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D002746:Chlorpromazine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008928:Mitochondria / Q000187:drug effects* / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D013096:Spermine / Q000494:pharmacology
D013096:Spermine; D011188:Potassium; D002746:Chlorpromazine