title: Interaction between manganese and phenobarbital on hexobarbital hypnosis in the male rat.
abstract: Pretreatment of male rats with phenobarbital markedly decreases while treatment with manganese prolongs the duration of hexobarbital hypnosis in male rats. When both agents were administered simultaneously, the manganese-induced prolongation of hexobarbital was prevented.
mesh_terms: D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D004347:Drug Interactions; D006591:Hexobarbital / Q000378:metabolism / Q000494:pharmacology*; D006991:Hypnosis, Anesthetic; D008297:Male; D008345:Manganese / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats
chemical_list: D008345:Manganese; D006591:Hexobarbital; D010634:Phenobarbital