Chronic hepatitis after successive halothane anesthetics.
A woman with cancer of the cervix had over a 4-week period three anesthetics with halogenated anesthetic agents, halothane, enflurane and halothane. 1 day after the third halothane anesthetic she developed fever and jaundice with biochemical evidence of severe hepatitis. Liver biopsy 10 days after the onset of jaundice showed features of acute hepatitis with bridging necrosis and piecemeal necrosis. A second biopsy after 10 months showed quiescent cirrhosis with residual piecemeal necrosis. The case is reported as a further example of halothane hepatitis evolving to cirrhosis of the liver.
D000769:Anesthesia, Inhalation / Q000009:adverse effects*; D001327:Autoimmune Diseases / Q000276:immunology; D001707:Biopsy, Needle; D004737:Enflurane / Q000009:adverse effects*; D005260:Female; D006221:Halothane / Q000009:adverse effects*; D006521:Hepatitis, Chronic / Q000150:complications / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008103:Liver Cirrhosis / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged
D004737:Enflurane; D006221:Halothane