title: Catheter-related thrombosis and fibrinolytic therapy.
abstract: Fifty-seven local transcatheter infusions of low doses of fibrinolytic agents for the treatment of occlusive vascular disease were performed in 49 patients. Thrombosis developed around the infusing catheter in 15 (26%) of these cases. Patients with occlusive vascular disease are at increased risk for the development of thrombosis around indwelling catheters because of the low flow state that exists proximal to the occlusion.
mesh_terms: D000328:Adult; D000368:Aged; D002404:Catheterization / Q000009:adverse effects*; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011859:Radiography; D012306:Risk; D013300:Streptokinase / Q000008:administration & dosage; D013927:Thrombosis / Q000000981:diagnostic imaging / Q000209:etiology*; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage; D014652:Vascular Diseases / Q000188:drug therapy
chemical_list: D005343:Fibrinolytic Agents; D013300:Streptokinase; D014568:Urokinase-Type Plasminogen Activator