[Renin-angiotensin system under extracorporeal circulation during heart valve surgery].
Angiotensin I (A I), angiotensin II (A II) and the activity of angiotensin-converting enzyme (ACE) were measured in 15 patients undergoing cardiopulmonary bypass for mitral or aortic valve replacement. During cardiopulmonary bypass A I, A II, A I/II ratio and arteriovenous A II--difference decreased markedly, whereas the activity of ACE fell only during a small 15 min period after start of extracorporeal circulation. Possible reasons for these effects are discussed.
D000803:Angiotensin I / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D001021:Aortic Valve / Q000601:surgery; D002315:Cardiopulmonary Bypass; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood / Q000601:surgery*; D006350:Heart Valve Prosthesis; D006801:Humans; D001121:Lysine Carboxypeptidase / Q000097:blood; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery; D012084:Renin-Angiotensin System
D000804:Angiotensin II; D000803:Angiotensin I; D001121:Lysine Carboxypeptidase
Das Renin-Angiotensin-System unter extrakorporaler Zirkulation während Herzklappenoperationen.