title: HLA antigens and the reactivity of lymphocytes to some drugs and PHA.
abstract: Peripheral blood lymphocytes from 15 healthy subjects, selected on the basis of their HLA types, were cultured in vitro in the presence of PHA and of a number of drugs which bind adrenergic or dopaminergic receptors (dopamine, norepinephrine, chlorpromazine, haloperidol, propranolol and apomorphine). The results obtained are consistent with an interference between HLA-A1 and cross-reacting specificities and the effect explained by these drugs on the lymphocyte activation by PHA. The possibility is suggested that HLA-A1 and cross-reacting antigens interfere with the binding of such drugs to the cell membrane receptors.
mesh_terms: D000328:Adult; D003429:Cross Reactions; D006680:HLA Antigens / Q000276:immunology*; D015788:HLA-A1 Antigen; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D010835:Phytohemagglutinins / Q000037:antagonists & inhibitors*; D011941:Receptors, Adrenergic / Q000187:drug effects; D011954:Receptors, Dopamine / Q000187:drug effects; D013566:Sympathomimetics / Q000494:pharmacology*
chemical_list: D006680:HLA Antigens; D015788:HLA-A1 Antigen; D010835:Phytohemagglutinins; D011941:Receptors, Adrenergic; D011954:Receptors, Dopamine; D013566:Sympathomimetics