title: The possible role of opiates in habituation of responses recorded in the reticular formation of the frog, to peripheral stimulation.
abstract: Repeated stimulation can lead to a decrement in the amplitude of a response, or its disappearance. This is known as habituation. Responses recorded in the reticular formation of the brain to peripherally applied stimuli tend to habituate. Decerebration considerably reduces the occurrence of this habituation and naloxone reverses the effect. In decerebrate animals in which such responses rarely habituate, habituation can be induced by administration of D-Ala2,Met5-enkephalinamide and then reversed by a subsequent administration of naloxone. This would suggest that opiates are involved in habituation of responses recorded in the reticular formation of the frog.
mesh_terms: D000818:Animals; D003655:Decerebrate State / Q000503:physiopathology; D004723:Endorphins / Q000502:physiology*; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives / Q000494:pharmacology; D006185:Habituation, Psychophysiologic / Q000187:drug effects / Q000502:physiology*; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D011896:Rana temporaria; D012154:Reticular Formation / Q000187:drug effects / Q000502:physiology*
chemical_list: D004723:Endorphins; D009270:Naloxone; D004744:Enkephalin, Methionine; C032818:enkephalinamide-Met, Ala(2)-N-Me(5)-; D009020:Morphine