Unstable activator models for size control of the cell cycle.
The unstable activator model of Wheals & Silverman (1982) is extended to account for the delay of nuclear division in the acellular slime mold, Physarum polycephalum, that is caused by pulse treatments with inhibitors of protein synthesis. The model is solved exactly to predict the delay as a function of the half-life of the activator. The Wheals-Silverman model is found to give results comparable, but not superior, to other unstable activator models of the cell cycle.
D002453:Cell Cycle; D002455:Cell Division; D002467:Cell Nucleus / Q000502:physiology; D008954:Models, Biological; D010804:Physarum / Q000166:cytology