Significance of the biphasic developmental pattern of the hypothalamo-pituitary-adrenocortical system in the rat.
One group of neonatal rats was injected with metopirone at 2-5 days and the second group at 7-10 days of age. At 14 and 21 days all rats treated with metopirone had reduced body and adrenal weights in comparison with their saline-treated littermates. At 21 days the smallest adrenals were in the rats treated with metopirone at 7-10 days. Metopirone increased resting and stress levels of adrenal and plasma corticosterone in the 14-day-old rats and the response to stress by the adrenal corticosterone increase in the 21-day-old rats. The differential effect of metopirone applied in two developmental periods was indicated.
D000311:Adrenal Glands / Q000032:analysis; D000367:Age Factors; D000818:Animals; D003345:Corticosterone / Q000032:analysis / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology*; D008797:Metyrapone / Q000494:pharmacology*; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D003345:Corticosterone; D008797:Metyrapone