Tumorigenicity of arsenic trioxide to the lung in Syrian golden hamsters by intermittent instillations.
The tumorigenicity of arsenic trioxide was investigated in female Syrian golden hamsters which were given a total of 5.25 mg or 3.75 mg as arsenic by intratracheal instillations once a week. As controls, hamsters were treated with the vehicle, phosphate buffer solution. During the total life span, 3 lung adenomas were manifested in 10 hamsters or 2 lung adenomas in another 20 hamsters after 15 instillations of arsenic, while no lung tumor was detected among 35 hamsters in 2 control groups. The results show that arsenic trioxide is tumorigenic to the lung of Syrian golden hamsters.
D000236:Adenoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D001151:Arsenic / Q000008:administration & dosage / Q000633:toxicity*; D000077237:Arsenic Trioxide; D001152:Arsenicals; D006224:Cricetinae; D005260:Female; D008175:Lung Neoplasms / Q000139:chemically induced* / Q000473:pathology; D008647:Mesocricetus; D010087:Oxides; D011336:Probability; D014132:Trachea
D001152:Arsenicals; D010087:Oxides; D001151:Arsenic; D000077237:Arsenic Trioxide