[Radioprotective effect of superoxide dismutase and a deuteroporphyrin-IX derivative on radiation-damaged mammalian cells].
In experiments on SOC cells, using the methods of mathematical scheduling of experiment and the computer analysis of the results obtained it was shown that the radioprotective agents, superoxide dismutase and 2,4 di-(alpha-methoxyethyl)deuteroporphyrine-IX, applied in a combination, produced an independent and additive effect on survival of irradiated cells.
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D003905:Deuteroporphyrins / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D006321:Heart; D008252:Macaca fascicularis; D011166:Porphyrins / Q000008:administration & dosage*; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D013482:Superoxide Dismutase / Q000008:administration & dosage*
D003905:Deuteroporphyrins; D004338:Drug Combinations; D011166:Porphyrins; D011837:Radiation-Protective Agents; C036303:2,4-di-(alpha-methoxyethyl)deuteroporphyrin IX; D013482:Superoxide Dismutase
Radiozashchitnoe deĭstvie superoksiddismutazy i proizvodnogo deĭteroporfirina-IX na povrezhdennye radiatsieĭ kletki mlekopitaiushchego.