Neutrophyl function in children with chondrodystrophia calcificans congenita: evidence for defective chemotaxis.
Some neutrophil functions (superoxide anion production, bactericidal activity and chemotaxis) have been examined in four children with Chondrodystrophia Calcificans Congenita. Superoxide anion production and bactericidal activity were in the normal range, but a defect in cellular chemotaxis has been proved. This finding account for predisposition to infection which is frequently present in these patients, and may include this disease among those syndromes in which a deficiency of the immune system is associated with growth failure.
D001770:Blood Bactericidal Activity; D002634:Chemotaxis, Leukocyte; D002648:Child; D002675:Child, Preschool; D002806:Chondrodysplasia Punctata / Q000276:immunology*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009504:Neutrophils / Q000276:immunology*