title: [Elevated prolactin reserves in gonadal dysgenesis and agonadism].
abstract: Prolactin-reserve before and after TRH-stimulation was studied in 12 patients with gonadal dysgenesis and 2 children with agonadism. 7 patients (50%) had moderately increased basal PRL levels and 13 (93%) showed exaggerated PRL-responses to TRH at 30 min. The increased prolactin-reserve was independent of age and karyotype of our patients. Cause and significance of this observation remains to be clarified. It is speculated that elevated PRL-levels could be only a side-effect of hypergonadotropism in hypo- and agonadal subjects.
mesh_terms: D000293:Adolescent; D002648:Child; D005260:Female; D006059:Gonadal Dysgenesis / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007621:Karyotyping; D011388:Prolactin / Q000097:blood*
chemical_list: D011388:Prolactin
vernacular_title: Erhöhte Prolaktinreserve bei Gonadendysgenesie und Agonadismus.