title: Taste and nicotine as determinants of voluntary tobacco use by hamsters.
abstract: Syrian hamsters consumed a commercial chewing tobacco in daily amounts equivalent to 2.6% of their body weights, even though food and water were always available. Daily intake increased gradually to this level over a period of 4 months. Commercial tobaccos contain a variety of flavoring agents, including sugars. Moistened, unflavored tobacco was consumed in much smaller amounts than the commercial tobacco. Addition of sucrose to the unflavored tobacco produced a concentration-dependent increase in daily consumption. Addition of nicotine to the drinking water did not affect daily fluid intake or food consumption, but produced a selective, dose-related decrease in consumption of the commercial tobacco. These results indicate interactive roles for taste and nicotine in controlling the daily, voluntary, high-level use of tobacco by hamsters.
mesh_terms: D000818:Animals; D006224:Cricetinae; D008297:Male; D008647:Mesocricetus; D009538:Nicotine / Q000494:pharmacology*; D010947:Plants, Toxic; D013649:Taste; D013997:Time Factors; D014026:Nicotiana
chemical_list: D009538:Nicotine