[Interaction of pipolfen and suprastin with human serum albumin depending on the pH of the medium and its calcium ion content].
Experiments made with the use of equilibrium dialysis and differential spectrophotometry have shown that pipolfen and difenhydramine interact actively with human serum albumin at pH 6.8-7.4. Calcium ions have been demonstrated to activate the interaction of pipolphen and diphenhydramine with albumin.
D002118:Calcium / Q000378:metabolism*; D004347:Drug Interactions; D005029:Ethylenediamines / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D011398:Promethazine / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects; D012709:Serum Albumin / Q000378:metabolism*; D013997:Time Factors
D005029:Ethylenediamines; D012709:Serum Albumin; C004664:chloropyramine; D011398:Promethazine; D002118:Calcium
Vzaimodeĭstvie pipol'fena i suprastina s syvorotochnym al'buminom cheloveka v zavisimosti ot pH sredy i soderzhaniia v neĭ ionov kal'tsiia.