title: In-vivo effects of clindamycin on neutrophil function--a preliminary report.
abstract: Neutrophil functions were evaluated in six normal subjects who had received 300 mg of clindamycin orally four times each day for two days. The mean serum concentration was 1.0 mg/l at the time of neutrophil collection. Clindamycin increased phagocytosis of a clindamycin-resistant staphylococcus from 0.8 to 1.0 organism per polymorphonuclear leukocyte (P less than 0.05). The proportion of killed intracellular bacteria increased from 23.8% to 29.8%. Zymosan-induced chemiluminescence was reduced from 130 X 10(3) to 86 X 10(3) counts per 0.2 min (P less than 0.05). Chemotaxis was unaffected. These preliminary results demonstrate measurable effects of clindamycin on neutrophil functions in the host; however, further studies are needed in order to confirm the observed changes.
mesh_terms: D000328:Adult; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D002981:Clindamycin / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects; D008163:Luminescent Measurements; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects
chemical_list: D002981:Clindamycin