Lactate production in a pure red muscle in absence of anoxia: mechanisms and significance.
Neither lactate accumulation in nor lactate release from muscle tissue can be used as evidence of anoxic tissue. We propose that the principal function of the lactate accumulation in tissue is to buffer cytosolic NADH levels and promote AEROBIC ATP production. This aerobic function of lactate metabolism should increase efficiency and extend the range of muscle performance.
D000818:Animals; D004285:Dogs; D006019:Glycolysis; D000860:Hypoxia / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D007773:Lactates / Q000096:biosynthesis*; D019344:Lactic Acid; D008931:Mitochondria, Muscle / Q000378:metabolism; D009132:Muscles / Q000098:blood supply / Q000378:metabolism*; D009211:Myoglobin / Q000378:metabolism; D010101:Oxygen Consumption; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D012039:Regional Blood Flow
D007773:Lactates; D009211:Myoglobin; D011773:Pyruvates; D019344:Lactic Acid; D019289:Pyruvic Acid