The possible role of ATP-dependent proteolysis on the solubilization of methemoglobin reductase during reticulocyte maturation.
The ATP-dependent proteolytic system present in reticulocytes can release the active hydrophilic domain of cytochrome b5 and NADH-cytochrome b5 reductase from the endoplasmic reticulum, that in mature erythrocytes act as methemoglobin reductase.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D003579:Cytochrome Reductases / Q000378:metabolism; D003573:Cytochrome b Group / Q000378:metabolism; D042966:Cytochrome-B(5) Reductase / Q000378:metabolism*; D015786:Cytochromes b5; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D012156:Reticulocytes / Q000201:enzymology*; D012995:Solubility
D003573:Cytochrome b Group; D000255:Adenosine Triphosphate; D015786:Cytochromes b5; D009247:NADH, NADPH Oxidoreductases; D003579:Cytochrome Reductases; D042966:Cytochrome-B(5) Reductase