Linkage of the equine serum esterase (Es) and mitochondrial glutamate oxaloacetate transaminase (GOTM) loci. A horse-mouse homology.
Three previously described electrophoretic phenotypes of mitochondrial glutamate oxaloacetate transaminase (GOTM) in horse leukocytes are shown to be controlled by two codominant alleles at a single autosomal locus. The GOTM locus is linked to the serum esterase locus (Es), as no recombination between these loci was observed among 16 informative offspring in one sire family. The results assign GOTM to equine linkage group (LG) II. The hypothesis that a part of LG II (e-Es) shares homologies with mouse chromosome 8 is thus confirmed, as the murine homologue of GOTM is located within the cluster of esterase loci on chromosome 8. The assumed homology also involves rabbit LG VI, rat LG V, and human chromosome 16. The observation is a striking example of the conservation of linkage relationships between mammalian species.
D000818:Animals; D001219:Aspartate Aminotransferases / Q000235:genetics*; D002874:Chromosome Mapping; D004950:Esterases / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D006736:Horses / Q000097:blood / Q000235:genetics*; D006801:Humans; D008297:Male; D051379:Mice; D008928:Mitochondria / Q000201:enzymology; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D001219:Aspartate Aminotransferases; D004950:Esterases