title: Precipitation of type-I (upgrading) reaction in leprosy by skin testing with antigen and irritants.
abstract: Twenty patients of various types of leprosy were skin tested with lepromin, PPD and DNCB to assess their immunological status. Two of the twenty (18 BT; 2 BB) patients belonging to BT type developed signs of acute neuritis of sudden onset about 4 weeks after the test with DNCB, lepromin and PPD. The patients were on DDS therapy already for the last 3-4 months. Presumably DNCB, PPD or lepromin testing had precipitated the reaction. A suggestion is made that lepromin a lower concentration could be used initially and if it gives negative reaction, a higher concentration may be used as in case of PPD testing, particularly in TT and BT cases already put on treatment.
mesh_terms: D000328:Adult; D003622:Dapsone / Q000627:therapeutic use; D004137:Dinitrochlorobenzene / Q000276:immunology*; D006801:Humans; D007509:Irritants; D007916:Lepromin / Q000276:immunology*; D007918:Leprosy / Q000188:drug therapy / Q000276:immunology*; D008297:Male; D009443:Neuritis / Q000209:etiology; D009578:Nitrobenzenes / Q000276:immunology*; D012882:Skin Tests; D014374:Tuberculin Test
chemical_list: D004137:Dinitrochlorobenzene; D007509:Irritants; D009578:Nitrobenzenes; D007916:Lepromin; D003622:Dapsone