title: Combined ulcerogenic effect of ethanol and acetylsalicylic acid on the gastric mucosa of the rat.
abstract: The effect on rat gastric mucosa of ethanol and acetylsalicylic acid given at two doses singly or in combination were studied by administering the drugs into the stomach. 40% ethanol alone caused many ulcerations after 5 h, and the effect was even more marked with simultaneous administration of acetylsalicylic acid (ASA). 10% ethanol and 50 mg ASA/kg b. wt. were tolerated well. The mucosal lesions consisted of coagulation necrosis and hemorrhages, with a disappearance of histamine and serotonin from the mucosal mast cells in and around the lesion.
mesh_terms: D000818:Animals; D001241:Aspirin / Q000633:toxicity*; D004357:Drug Synergism; D000431:Ethanol / Q000633:toxicity*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D006632:Histamine / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D013276:Stomach Ulcer / Q000139:chemically induced* / Q000473:pathology
chemical_list: D012701:Serotonin; D000431:Ethanol; D006632:Histamine; D001241:Aspirin