title: Dermatofibrosarcoma protuberans metastatic to lymph nodes and showing a dominant histiocytic component.
abstract: Dermatofibrosarcoma protuberans is a neoplasm composed of cells that have morphologic characteristics of fibroblasts and histiocytes. We report the eighth documented case of dermatofibroma protuberans metastatic to regional lymph nodes. The metastases consisted predominantly of cells that appeared to be atypical histiocytes. This case is considered to be an example of dermatofibroma protuberans in which primitive histiocytic cells have not acquired secondarily acquired fibroblastic characteristics.
mesh_terms: D000328:Adult; D001365:Axilla; D001859:Bone Neoplasms / Q000556:secondary; D003131:Combined Modality Therapy; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology* / Q000556:secondary / Q000628:therapy; D006801:Humans; D006811:Humerus; D008207:Lymphatic Metastasis; D012878:Skin Neoplasms / Q000473:pathology* / Q000628:therapy