Enhancement by potassium bromate of renal tumorigenesis initiated by N-ethyl-N-hydroxyethylnitrosamine in F-344 rats.
The effect of potassium bromate, a food additive, was examined in male F-344 rats based on two-stage renal carcinogenesis with N-ethyl-N-hydroxyethylnitrosamine (EHEN) as an initiator. Average numbers of dysplastic foci and renal cell tumors were significantly increased in rats given potassium bromate after initiation with EHEN. It was concluded that potassium bromate has an enhancing effect on renal tumorigenesis.
D000818:Animals; D001959:Bromates / Q000633:toxicity*; D001966:Bromine / Q000633:toxicity*; D004052:Diethylnitrosamine / Q000031:analogs & derivatives; D005503:Food Additives / Q000633:toxicity*; D007680:Kidney Neoplasms / Q000139:chemically induced*; D008297:Male; D009602:Nitrosamines; D051381:Rats; D011916:Rats, Inbred F344
D001959:Bromates; D005503:Food Additives; D009602:Nitrosamines; C019536:potassium bromate; C023845:N-ethyl-N-hydroxyethylnitrosamine; D004052:Diethylnitrosamine; D001966:Bromine