title: Prevention of posthysterectomy infection with a combination of preoperative vaginal and perioperative intravenous administration of metronidazole.
abstract: In a prospective double-blind study 58 patients received 1000 mg of metronidazole vaginally 12--16 hours preoperatively and 500 mg intravenously during abdominal hysterectomy while 54 patients were treated with placebo. The lack of all operative site infections in the metronidazole group in comparison with 9 infections (17%) in the placebo group (P less than 0.01) proved the combined short-term vaginal and intravenous use of metronidazole to be efficacious in the prevention of posthysterectomy infections.
mesh_terms: D000328:Adult; D000368:Aged; D001421:Bacteria, Anaerobic; D001424:Bacterial Infections / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007044:Hysterectomy; D007263:Infusions, Parenteral; D007432:Intraoperative Period; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D011292:Premedication; D014552:Urinary Tract Infections / Q000517:prevention & control; D014621:Vagina / Q000382:microbiology; D014946:Wound Infection / Q000517:prevention & control
chemical_list: D008795:Metronidazole