title: Actual role of pepsinogen group I in the study of upper gastrointestinal diseases.
abstract: The role of serum PG I in screening patients with chronic atrophic gastritis and gastric cancer, and in detecting peptic ulcer patients with high relapse risk, was ascertained in 276 subjects. Although not diagnostic per se, PG I was found to be under 20 micrograms/L in patients with chronic atrophic gastritis and in some gastric cancer or partially gastrectomized patients. In patients presenting with relapsing duodenal ulcer, PG I values were significantly higher than in the non-relapsing ones, but a satisfactory identification of all the duodenal ulcer patients with high relapse risk was not possible on this basis. Even the correlation between PG I and MAO was not accurate in every subject considered. These results suggest that the value of PG I is limited to assessing patients with upper gastrointestinal diseases in which a reduction of peptic secretion, and therefore of PG I in serum, is present.
mesh_terms: D004381:Duodenal Ulcer / Q000097:blood; D005750:Gastric Juice / Q000378:metabolism; D005756:Gastritis / Q000175:diagnosis; D005767:Gastrointestinal Diseases / Q000097:blood* / Q000175:diagnosis; D006801:Humans; D010435:Pepsinogens / Q000097:blood*; D013274:Stomach Neoplasms / Q000175:diagnosis; D013276:Stomach Ulcer / Q000097:blood
chemical_list: D010435:Pepsinogens