title: Nonparametric pharmacokinetic calculations: one-compartment open model.
abstract: A nonparametric method suitable for estimation of parameters in nonlinear problems was developed for one-compartment pharmacokinetic data. The method was tested by running 500 simulations with various types of error and comparing the results with a standard nonlinear regression computation. The nonparametric method was superior to nonlinear regression techniques if the assumptions for the error structure of the regression were not true.
mesh_terms: D007700:Kinetics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*
chemical_list: D004364:Pharmaceutical Preparations