title: [Skin necroses and ergotism after preventive administration of heparin-dihydroergotamine].
abstract: About 30 hours after prophylactic subcutaneous administration of heparin-dihydroergotamine to a 77-year-old man with generalized arteriosclerosis, extensive skin necroses developed at the injection sites and, after progressively increasing signs of mental disorientation, three days later there developed acute pulmonary oedema and a large ischaemic infarct of the median cerebral artery with hemiparesis and coma, which ended fatally. Skin necroses and ergotism are rare but serious complications of anticoagulant treatment.
mesh_terms: D000368:Aged; D002544:Cerebral Infarction / Q000139:chemically induced; D004087:Dihydroergotamine / Q000009:adverse effects*; D004881:Ergotism / Q000209:etiology*; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009336:Necrosis; D011654:Pulmonary Edema / Q000139:chemically induced; D012871:Skin Diseases / Q000139:chemically induced*; D013923:Thromboembolism / Q000517:prevention & control
chemical_list: D004087:Dihydroergotamine; D006493:Heparin
vernacular_title: Hautnekrosen und Ergotismus nach prophylaktischer Gabe von Heparin-Dihydroergotamin.