title: [Desensitisation with hymenoptera venom in children].
abstract: The efficiency of immunotherapy with hymenoptera venom is well known in adults. Its clinical tolerance and its immunologic consequences during an accelerated desensitization program were studied in children with bee venom (n = 12, average age: 9.4 +/- 4.6 years) or wasp venom (n = 6, average age: 10.4 +/- 3.7 years) hypersensitivity. Results were compared with those obtained in adults susceptible to bee venom (n = 15, average age: 36.6 +/- 10.4 years) or to wasp venom (n = 18, average age: 36.2 +/- 7.4 years). Despite doses identical to those used in adults, clinical tolerance was better in both groups of children. Provocation tests (6 children, 10 adults) after immunotherapy showed a similar efficiency of the treatment in adults and children. The immunologic study showed a significantly greater increase in specific IgG in children, and a significant decrease in specific IgE (p less than 0.05) only in children treated with bee venom.
mesh_terms: D000293:Adolescent; D000328:Adult; D001180:Arthropod Venoms / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D003888:Desensitization, Immunologic; D005260:Female; D006801:Humans; D006927:Hymenoptera / Q000276:immunology*; D007073:Immunoglobulin E / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D001180:Arthropod Venoms; D007074:Immunoglobulin G; D007073:Immunoglobulin E
vernacular_title: Désensibilisation au venin d'hyménoptères chez l'enfant.