[Changes in thermoregulation in the white mouse treated with endogenous substances from the intestinal tissue of hibernating animals].
Intraperitoneal administration of extracts of the small intestine epithelium of hibernating ground squirrels (C. Parryi Rich., C. undulatus) to white mice caused a decrease in oxygen consumption by 50-80%, the 5.5-14.0 degrees C drop in body temperature, inhibition of the muscle shivering thermogenesis, a decrease in heart rate, reduction of locomotor activity, development of hypnogenic effect and a closer dependence of body temperature on environmental fluctuations. The effects lasted for 30-40 hrs. Extracts from the small intestine tissue of non-hibernating ground squirrels caused insignificant changes of these parameters.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D001921:Brain / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D006605:Hibernation; D007413:Intestinal Mucosa; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D012589:Sciuridae / Q000378:metabolism*; D012768:Shivering / Q000187:drug effects; D014020:Tissue Extracts / Q000494:pharmacology*
D014020:Tissue Extracts
Izmeneniia termoreguliatsii u belykh mysheĭ pri deĭstvii éndogennykh veshchestv iz tkani kishechnika zimospiashchikh.