title: [Comparison of 3 6-month chemotherapy regimes in pulmonary tuberculosis in routine practice in Algiers. 18th-month results].
abstract: Three 6 month antituberculous regimes were compared during a controlled trial in Algiers. Isoniazid and Rifampicin were used every day for six months in all three regimes; a third drug was used as a supplement in two of the three regimes during the first three months (Ethambutol or Pyrazinamide). The aim of the study was to assess the role of the third drug and also the suitability of a self-administered regime in routine practice. The results were analysed at eighteen months, twelve months after the end of therapy. The third drug had no influence on outcome in patients with sensitive organisms. There was a 2.5% relapse rate with no significant difference between the groups. On the other hand the third drug was crucial for those patients initially resistant to Isoniazid, because a relapse or failure due to primary resistance was avoided. The 6 month regimes were well tolerated: the treatment was only changed in 0.8% of cases for major toxicity. Finally, short self-administered oral regimens were well tolerated by the patients.
mesh_terms: D000293:Adolescent; D000328:Adult; D000995:Antitubercular Agents / Q000008:administration & dosage*; D004341:Drug Evaluation; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination; D004977:Ethambutol / Q000008:administration & dosage; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage; D008297:Male; D011718:Pyrazinamide / Q000008:administration & dosage; D012293:Rifampin / Q000008:administration & dosage; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D011718:Pyrazinamide; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin
vernacular_title: Comparaison de trois régimes de chimiothérapie de 6 mois dans la tuberculose pulmonaire en pratique de routine à Alger. Résultats au 18e mois.