[Blood and cerebrospinal fluid levels of bupivacaine in spinal anesthesia].
Blood and liquor concentrations of bupivacaine were followed in 20 patients after spinal injection of 15 mg bupivacaine-HCl or bupivacaine-CO2; determination of the local anaesthetic was done by gas chromatography. Whole-blood concentrations of bupivacaine for both formulations lay between 0.2 and 0.3 microgram/ml. Two min after intrathecal administration of 15 mg bupivacaine, liquor concentrations averaged around 600 micrograms/ml, i.e., the precipitation threshold was not reached. Concentrations of individual patients, however, indicated that considerably higher concentrations can be attained; the possible reasons are discussed. Bupivacaine-CO2 represents a suitable preparation for spinal anesthesia, which, particularly with regard to blood levels, shows no disadvantages compared to bupivacaine-HCl.
D000328:Adult; D000775:Anesthesia, Spinal; D002045:Bupivacaine / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D002849:Chromatography, Gas; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D013997:Time Factors
D002045:Bupivacaine
Blut- und Liquorspiegel von Bupivacain bei Spinalanaesthesien.