title: Interaction of Clostridium difficile toxins and mouse hepatic microsomes.
abstract: Intraperitoneal administration of toxins of Clostridium difficile to mice resulted in loss of hepatic cytochrome P450 and peroxidation of microsomal lipids. Pretreatment with the microsomal enzyme inducer beta-naphthoflavone partially alleviated these effects and increased survival time of intoxicated animals.
mesh_terms: D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D003013:Clostridium; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003573:Cytochrome b Group / Q000378:metabolism; D003580:Cytochromes / Q000378:metabolism; D015786:Cytochromes b5; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000096:biosynthesis; D051379:Mice; D008813:Mice, Inbred ICR; D008862:Microsomes, Liver / Q000378:metabolism*
chemical_list: D001427:Bacterial Toxins; D003573:Cytochrome b Group; D003580:Cytochromes; D008054:Lipid Peroxides; D008315:Malondialdehyde; D015786:Cytochromes b5; C013464:cytochrome P420; D003577:Cytochrome P-450 Enzyme System