Single dose carcinogenicity of procarbazine in rats.
Rats carrying a 2-day-old subcutaneous air pouch were treated with single doses of procarbazine. Local fibrosarcomas developed in the pouch after oral, intraperitoneal and local administration of 300 mg/kg, but no tumours were induced if the drug was injected into unstimulated subcutaneous tissue. Tumours only appeared in those animals in which growth of the granuloma tissue was stimulated with a dose of croton oil. The high dose of procarbazine (300 mg/kg) also induced an increase in total tumour incidence at other sites.
D000236:Adenoma / Q000139:chemically induced; D000388:Air; D000818:Animals; D002277:Carcinoma / Q000139:chemically induced; D003436:Croton Oil; D005354:Fibrosarcoma / Q000139:chemically induced*; D006099:Granuloma / Q000473:pathology; D007274:Injections, Intraperitoneal; D007279:Injections, Subcutaneous; D008297:Male; D011336:Probability; D011344:Procarbazine / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D011344:Procarbazine; D003436:Croton Oil