title: Tetrodotoxin-resistant non-cholinergic neurogenic contraction evoked by capsaicinoids and piperine on the guinea-pig trachea.
abstract: Contraction of the isolated tracheal strip to capsaicin was prevented by chronic denervation of the tissue. Tetrodotoxin, hyoscine and hexamethonium caused no inhibition of the response, suggesting that tetrodotoxin-resistant terminal portions of non-cholinergic nerves were activated in this way. There was a strong correlation between the pain-producing and tracheoconstrictor effects of piperine, pungent and non-pungent capsaicin congeners. Common site of action was evidenced by crossed tachyphylaxis. It is concluded that the capsaicin-sensitive sensory nerve endings have a dual sensory-efferent function. Excitation-secretion coupling in this system could operate without an axon reflex.
mesh_terms: D000470:Alkaloids; D000818:Animals; D052117:Benzodioxoles; D002211:Capsaicin / Q000494:pharmacology*; D003714:Denervation; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006168:Guinea Pigs; D009130:Muscle, Smooth / Q000294:innervation*; D009469:Neuromuscular Junction / Q000187:drug effects*; D010146:Pain / Q000139:chemically induced; D010880:Piperidines / Q000494:pharmacology*; D053284:Polyunsaturated Alkamides; D013779:Tetrodotoxin / Q000494:pharmacology*; D014132:Trachea
chemical_list: D000470:Alkaloids; D052117:Benzodioxoles; D010880:Piperidines; D053284:Polyunsaturated Alkamides; D013779:Tetrodotoxin; D002211:Capsaicin; C008922:piperine