Release of gamma-aminobutyric acid from guinea pig myenteric plexus synaptosomes.
A crude synaptosomal preparation obtained from myenteric plexus of guinea pig small intestine was used to study the release of [3H]GABA. GABA release was elevated in response to depolarizing agents when tested in normal Krebs but was depressed in a calcium-free medium. GABA was also noted to stimulate a release of [3H]ACh from the same preparation. These data support the possible role of GABA as an enteric neurotransmitter.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D006168:Guinea Pigs; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009197:Myenteric Plexus / Q000378:metabolism* / Q000648:ultrastructure; D013569:Synapses / Q000378:metabolism; D013574:Synaptosomes / Q000201:enzymology / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism* / Q000494:pharmacology
D005680:gamma-Aminobutyric Acid; D007770:L-Lactate Dehydrogenase; D000109:Acetylcholine