Free and complexed anti-lipoprotein antibodies in vascular diseases.
The cell-mediated immune response against low density lipoproteins (LDL) was demonstrated by the migration inhibition test in patients with various vascular diseases. Anti-high density lipoprotein2 (HDL2) cellular immune response was found only in a few patients. LDL and HDL2 binding factors were detected in about 50% of coronary patients. No significant difference in their occurrence was found between the normolipidemic and hyperlipidemic patients nor between patients with hyperlipidemia type II/b and type IV. On the assumption that lipoproteins may act as auto-antigens by forming immune complexes, the presence of anti-LDL and anti-HDL2 activity was investigated in circulating immune complexes obtained by polyethylene glycol (PEG) precipitation from the sera of coronary patients and controls. Using an ELISA technique, PEG-precipitable anti-LDL activity was detected in 23, 11 and 18% of cases with myocardial infarction, angina pectoris and healthy old subjects, respectively. In the immune complexes obtained from the sera of the healthy young donors no anti-LDL activity was found. Anti-HDL2 activity in the immune complexes was demonstrated only in a few cases from among the patients and elderly persons we investigated.
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000276:immunology; D000936:Antigen-Antibody Complex / Q000032:analysis; D001157:Arterial Occlusive Diseases / Q000276:immunology*; D003327:Coronary Disease / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D008075:Lipoproteins, HDL / Q000276:immunology; D008077:Lipoproteins, LDL / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000276:immunology
D000936:Antigen-Antibody Complex; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL