Compartmentation of glycolytic and glycogenolytic metabolism in vascular smooth muscle.
Vascular smooth muscle is characterized by a high rate of aerobic lactate production, which may be altered independently of oxidative phosphorylation. This finding suggested a cytoplasmic compartmentation of metabolism. Exogenous glucose was found to be the sole precursor of aerobic glycolysis under unstimulated conditions. Although tissue depolarization with high K+ resulted in a substantial reduction of endogenous glycogen, exogenous glucose remained the sole precursor of aerobic lactate production. These data showed unequivocally that carbohydrate metabolism is compartmentalized in vascular smooth muscle.
D000818:Animals; D002451:Cell Compartmentation; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism*; D006019:Glycolysis; D007773:Lactates / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000648:ultrastructure; D010085:Oxidative Phosphorylation; D011188:Potassium / Q000494:pharmacology; D013552:Swine
D007773:Lactates; D006003:Glycogen; D005947:Glucose; D011188:Potassium