title: Distribution of disulfiram in brain after carotid ligation in gerbils.
abstract: Aiming whether intraperitoneal administration of disulfiram (tetraethyl thiuram disulfide, DS) achieves potentially therapeutic drug concentrations in brain tissue, the behaviour of blood-brain barrier (BBB) to 14C-labelled DS in cerebral ischemia with and without simultaneous administration of dimethylsulfoxide (DMSO) was studied in Mongolian gerbils subjected to left common carotid artery (CCA) occlusion. The results indicated that: (a) the permeability of DS through the BBB was significantly enhanced in the ischemic brain during the initial 30 min duration after DS administration; (b) administration of DMSO increased the entry of DS into the ischemic brain five-fold during the first 30 min and it was significantly higher even at the 60 min sampling period; (3) in general, the content of DS in the brain was quickly reduced with time.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002545:Brain Ischemia / Q000503:physiopathology; D002339:Carotid Arteries / Q000502:physiology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D004221:Disulfiram / Q000378:metabolism*; D005849:Gerbillinae; D008026:Ligation
chemical_list: D004221:Disulfiram; D004121:Dimethyl Sulfoxide