Transient neutrophil aggregation in a patient with infectious mononucleosis.
Transient neutrophil aggregation is reported in a case of infectious mononucleosis. The phenomenon was observed on a blood film patient just before splenic infarction and decreased after splenectomy. The aggregation was so important that differential blood count could not be done. A high serum level of circulating immune complexes was found, and fluorescent spots inside of granulocytes, presumably engulfed immune complexes, could be observed. It is suggested that C activation associated with high immune complexes in infectious mononucleosis is a possible pathogenetic mechanism inducing PMNs aggregation and immune tissue damage.
D000328:Adult; D003182:Complement C5 / Q000494:pharmacology; D015936:Complement C5a; D006801:Humans; D007244:Infectious Mononucleosis / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D008297:Male; D009504:Neutrophils / Q000503:physiopathology*; D013161:Splenic Rupture / Q000150:complications
D003182:Complement C5; D015936:Complement C5a