Linkage analysis and family classification under heterogeneity.
Heterogeneity of the recombination fraction may or may not involve a mixture of two groups of elements. For the mixture situation (families with or without linkage between two gene loci), Morton's homogeneity test is compared with another test (Admixture test) with respect to significance level, power, parameter estimation and classification of families. The Admixture test is shown generally to have superior properties in this situation.
D002874:Chromosome Mapping; D005190:Family; D005191:Family Characteristics; D008040:Genetic Linkage; D006801:Humans; D008722:Methods; D011995:Recombination, Genetic