title: Rapid methods in studies on the genetic changes induced by chemicals.
abstract: Eight new compounds of the quaternary ammonium salts group were investigated for mutagenicity. Tests were carried out on onion roots (Allium test) and on bacteria (Ames' test) to examine the mitosis disturbances. None of the compounds produced mutagenic activity in the bacterial test, whereas in the Allium test two compounds produced a strong effect on mitotic cell division.
mesh_terms: D000818:Animals; D001419:Bacteria / Q000235:genetics; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism; D008938:Mitosis / Q000187:drug effects; D009152:Mutagenicity Tests / Q000379:methods*; D009153:Mutagens / Q000633:toxicity*; D010944:Plants / Q000235:genetics; D000644:Quaternary Ammonium Compounds / Q000633:toxicity*; D051381:Rats
chemical_list: D009153:Mutagens; D000644:Quaternary Ammonium Compounds