Ointment-based mechlorethamine treatment for mycosis fungoides.
The treatment of skin disease with topical mechlorethamine has been restricted because of the frequent development of contact dermatitis. A series of 43 patients with mycosis fungoides in Stages 1A (17), IB (22), II (2), and III (2) were treated with an ointment-based mechlorethamine, prepared by an anhydrous method. Complete clearing occurred in 26 patients over a 42-month evaluation period. The incidence of contact dermatitis was very low. Only 1 of 31 patients exposed to mechlorethamine for the first time, and only 3 of 12 patients with a history of previous hypersensitivity to mechlorethamine, developed contact dermatitis to the ointment-based mechlorethamine.
D000287:Administration, Topical; D003877:Dermatitis, Contact / Q000209:etiology; D005069:Evaluation Studies as Topic; D006801:Humans; D008466:Mechlorethamine / Q000008:administration & dosage* / Q000009:adverse effects; D009182:Mycosis Fungoides / Q000188:drug therapy*; D009824:Ointments
D009824:Ointments; D008466:Mechlorethamine