title: [Mechanism of the vasodilator action of kavinton on the cerebral vessels].
abstract: Experiments on human middle cerebral and cat internal maxillary arteries have shown high vasodilative activity of cavinton. The mechanism of the vasodilative action of the drug involves inhibition of the ingress of exocellular calcium via electrogenic and chemosensitive channels, suppression of calcium mobilization from the intracellular depot with depolarization of the membranes of vascular smooth cells and a decrease in phosphodiesterase activity.
mesh_terms: D000818:Animals; D002415:Cats; D002462:Cell Membrane / Q000187:drug effects; D002536:Cerebral Arteries / Q000187:drug effects*; D004594:Electrophysiology; D006801:Humans; D066298:In Vitro Techniques; D008438:Maxillary Artery / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*; D014748:Vinca Alkaloids / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; D014748:Vinca Alkaloids; C013983:vinpocetine
vernacular_title: Mekhanizm vazodilatatornogo deĭstviia kavintona na mozgovye sosudy.