Kupffer cell regulation of fibrinogen synthesis in hepatocytes.
Isolated rat liver macrophages (Kupffer cells) produce a factor(s) which stimulates fibrinogen synthesis 5-8 fold in hepatocyte cultures. The production of the stimulatory factor reached maximum during the first 24 hours the cells were in culture. When the cell culture medium was chromatographed on a calibrated Sephadex G-75 column the major activity peak eluted in the size range of 25,000-30,000 daltons. Taken together these results demonstrate that in addition to their well known phagocytic function, Kupffer cells secrete factor(s) that can significantly increase fibrinogen synthesis.
D000818:Animals; D002478:Cells, Cultured; D005340:Fibrinogen / Q000096:biosynthesis*; D007728:Kupffer Cells / Q000502:physiology*; D008099:Liver / Q000378:metabolism*; D008970:Molecular Weight; D051381:Rats
D005340:Fibrinogen