Evaluation of Propineb, a dithiocarbamate pesticide, in the mouse-sperm morphology assay.
Propineb, a dithiocarbamate fungicide, was studied by using the sperm morphology assay in (C57BL6 male X C3H female) F1 mice. At all dose levels, no statistically significant increase in the percentage of sperm abnormalities was observed. Methyl methanesulfonate (MMS) and 2-acetylaminofluorene (2-AAF), which were tested as positive controls, induced a dose-effect-related increase in teratospermia.
D015073:2-Acetylaminofluorene / Q000633:toxicity; D000818:Animals; D003433:Crosses, Genetic; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D008297:Male; D008741:Methyl Methanesulfonate / Q000633:toxicity; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*; D013723:Teratogens; D013737:Testis / Q000187:drug effects; D013859:Thiocarbamates / Q000633:toxicity*; D015038:Zineb / Q000031:analogs & derivatives / Q000633:toxicity*
D013723:Teratogens; D013859:Thiocarbamates; C012509:propineb; D015073:2-Acetylaminofluorene; D008741:Methyl Methanesulfonate; D015038:Zineb