[Synthesis and antibacterial activity of perchlorylchloramphenicol].
Starting from p-perchloryl acetophenone we have synthesized the perchloryl analogue of chloramphenicol. The new compound is the first chloramphenicol analogue possessing a higher antimicrobial activity as chloramphenicol itself. It showed an about twofold activity against 18 different microbes in the hole plate diffusion test, compared with the parent compound.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D002701:Chloramphenicol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D002701:Chloramphenicol; C039782:perchlorylchloramphenicol
Synthese und antibakterielle Aktivität von Perchlorylchloramphenicol.