[Change in the relative number of hematopoietic stem cells during long-term irradiation with different dose magnitudes].
In this work a model is proposed describing inactivation of colony-forming haemopoietic stem cells as a function of time during long-term irradiation within a wide range of dose-rates (from 0.01 to 100 Gy/day). There was a good agreement between theoretical and experimental data on the number of stem cells altered by irradiation of mice within the indicated range of dose-rates. It was shown that specific rate of cell division increased and the duration of the mitotic cycle decreased (from 98 h to 7 h) with increasing dose-rate by 3, or more, orders.
D000818:Animals; D002453:Cell Cycle / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D006412:Hematopoietic Stem Cells / Q000528:radiation effects*; D008433:Mathematics; D051379:Mice; D008954:Models, Biological; D013997:Time Factors
Nekotorye zakonomernosti izmeneniia otnositel'nogo chisla stvolovykh krovetvornykh kletok pri protiazhennom obluchenii s razlichnoĭ moshchnost'iu dozy.