[Synthesis of new derivatives of 3-benzyl-1,2-benzisothiazole and a study of analgesic activity in mice].
This paper describes the synthesis of 3-benzyl-1,2-benzisothiazole derivatives, structurally related to benzylisoquinolines, and their analgesic activity studied using writhing technique in the mouse. The presence of lipophilic substituents in position 3, 4 of the benzyl group give substances with analgesic activity, although their "potency" is lower than that shown by papaverine.
D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D051379:Mice; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D013997:Time Factors
D000700:Analgesics; D013844:Thiazoles
Sintesi di nuovi derivati del 3-benzil-1,2-benzisotiazolo e studio della attività analgesica nel topo.