Effect of 5-hydroxydopamine on the large dense-cored vesicles in the axon terminals of the myenteric ganglia of the guinea-pig stomach.
Quantitative ultrastructural analysis revealed that the large dense-cored vesicles in the axon terminals in the myenteric ganglia of the guinea-pig stomach tend to be concentrated towards the ends of the terminals. In guinea-pigs treated with 50 mg/kg 5-hydroxydopamine, diameters of the vesicles were increased and their distribution in the terminals was altered. Treatment with reserpine prior to 5-hydroxydopamine increased the proportion of large dense-cored vesicles and decreased the overall number of vesicles in the terminals. The diameter of the vesicles was increased both in the terminal profiles and in the non-terminal segments of the axons. These observations are consistent with the view that uptake of 5-hydroxydopamine into small vesicles is followed by their transformation into large dense-cored vesicles.
D000818:Animals; D001369:Axons / Q000187:drug effects* / Q000648:ultrastructure; D005724:Ganglia / Q000187:drug effects*; D006168:Guinea Pigs; D006892:Hydroxydopamines / Q000494:pharmacology*; D009197:Myenteric Plexus / Q000187:drug effects*; D012110:Reserpine / Q000494:pharmacology; D013270:Stomach / Q000294:innervation*
D006892:Hydroxydopamines; C027802:5-hydroxydopamine; D012110:Reserpine