Determination of pyridoxal phosphate levels in the brains of audiogenic and normal mice.
The concentrations of pyridoxal-5'-phosphate in the brains of audiogenic and normal mice were measured fluorimetrically. The brain of the audiogenic mouse (DBA/2J) contains 25% more pyridoxal-5'-phosphate than the brain of a control mouse. Intraperitoneal injection of this substance causes a transient increase of its concentration in the brain, lasting a few hours. The substance thereafter is degraded to pyridoxal and pyridoxic acid.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005260:Female; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D008815:Mice, Inbred Strains; D008817:Mice, Mutant Strains; D009419:Nerve Tissue Proteins / Q000032:analysis; D011732:Pyridoxal Phosphate / Q000378:metabolism*; D013045:Species Specificity; D013050:Spectrometry, Fluorescence
D009419:Nerve Tissue Proteins; D011732:Pyridoxal Phosphate