Synthesis and antibacterial activities of new (alpha-hydrazinobenzyl)cephalosporins.
Some (alpha-hydrazinobenzyl)cephalosporins, I (R = Me, CH2OAc, Cl) and II (R = Me, CH2OAc), structurally related (formula; see text) to cephalexin, cephaloglycin, and cefaclor have been prepared and evaluated in vitro for their antimicrobial activity. The synthesis involves the condensation of the chloride hydrochloride III (R = H or Me) with the 7-aminocephem derivatives IV. The hydrazino compound I (R = Cl), an analogue of cefaclor, resulted in being the most active compound of the series.
D001419:Bacteria / Q000187:drug effects; D002433:Cefaclor / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000633:toxicity; D002506:Cephalexin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000633:toxicity; D002507:Cephaloglycin / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000633:toxicity; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000633:toxicity; D006834:Hydrazines / Q000138:chemical synthesis / Q000633:toxicity; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D002511:Cephalosporins; D006834:Hydrazines; D007202:Indicators and Reagents; D002433:Cefaclor; D002507:Cephaloglycin; D002506:Cephalexin