title: [pH and buffer capacity of cerebrospinal fluid after spinal anesthesia].
abstract: In 20 patients, undergoing total hip or knee replacement, we studied pH and metabolic changes in the C.S.F. following spinal anaesthesia with two different mixtures of bupivacaine 0.5% and mepivacaine 4% hyperbaric. Our study was made with special regard to the early changes; therefore C.S.F. specimens were obtained at 1, 3, 5, 10, 20, 30, 60 and 90 min intervals and analyses of pH, pCO2, HCO3 and BE estimations were carried out immediately after each obtained sample. Our results showed a marked tendency towards acidosis and therefore do not comply with previous studies. The advantage of this fact is an improved stability of bupivacaine in C.S.F.
mesh_terms: D000368:Aged; D000775:Anesthesia, Spinal; D001639:Bicarbonates; D002021:Buffers; D002045:Bupivacaine; D002555:Cerebrospinal Fluid / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008619:Mepivacaine
chemical_list: D001639:Bicarbonates; D002021:Buffers; D008619:Mepivacaine; D002045:Bupivacaine
vernacular_title: pH und Pufferkapazität des Liquors nach Spinalanaesthesie.