Estimation of haplotype frequencies.
Maximum likelihood estimates of haplotype frequencies in multilocus systems are often zero and so may be genetically inacceptable. Estimation problems are discussed, and preferable estimates are derived.
D000483:Alleles; D000818:Animals; D005787:Gene Frequency; D006238:Haploidy; D006801:Humans; D008433:Mathematics; D008957:Models, Genetic; D010641:Phenotype; D011336:Probability