Effect of saccharin on the induction of chromosomal translocations in male mice and their F1 offspring.
The dose-dependent effects of sodium saccharin on the fertility and the induction of chromosomal translocations in treated mice and their F1 males were examined. C3H X 101 mice were treated with saccharin for 2 successive weeks at doses of 200 and 500 mg/kg of body wt. Data from the fertility study showed that saccharin did not induce any significant effect on fertility. Cytological analysis of meiotic cells showed no chromosomal rearrangements. Semisterility and sterility were noted in F1 males of saccharin-treated animals. In semi-sterile and sterile F1 males of saccharin-treated animals chromosomal translocations were not found.
D000818:Animals; D007248:Infertility, Male / Q000139:chemically induced* / Q000235:genetics; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D012439:Saccharin / Q000235:genetics / Q000633:toxicity*; D013091:Spermatogenesis / Q000187:drug effects; D014178:Translocation, Genetic / Q000187:drug effects*
D012439:Saccharin