Amoscanate as a topically applied chemical for prophylaxis against Schistosoma mansoni infections in mice.
Amoscanate (0.1% w/v) in methanol solution applied to skin by tail immersion 1 day prior to cercarial exposure provided mice with better than 90% protection against mature Schistosoma mansoni infections. Cercariae penetrated and schistosomula migrated from treated skins as readily as in control skins. Lung incubation assays, however, indicated that day 7 lung worm burdens were only about half those of control values. By day 20, worm burdens were reduced further to approximately 15% of those for control mice. The delayed prophylactic activity was apparently not due to percutaneously absorbed compound. Wipe application of amoscanate to the skin was nearly as effective as immersion.
D000287:Administration, Topical; D000814:Aniline Compounds / Q000627:therapeutic use*; D000818:Animals; D004159:Diphenylamine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D017879:Isothiocyanates; D008168:Lung / Q000469:parasitology; D008297:Male; D051379:Mice; D012550:Schistosoma mansoni / Q000502:physiology; D012552:Schistosomiasis / Q000517:prevention & control*; D012556:Schistosomicides / Q000627:therapeutic use*; D012867:Skin / Q000469:parasitology; D013861:Thiocyanates / Q000008:administration & dosage / Q000627:therapeutic use*
D000814:Aniline Compounds; D017879:Isothiocyanates; D012556:Schistosomicides; D013861:Thiocyanates; D004159:Diphenylamine; C012391:amoscanate