[Effects of gamma-vinyl GABA per os in 5 cases of hebephreno-catatonic schizophrenia].
gamma-Vinyl GABA, an irreversible inhibitor of GABA transaminase, was administered orally to five patients with catatonic or hebephreno-catatonic schizophrenia. Improvement of psychiatric symptoms was observed in four cases. The results are discussed in relation to previously reported attempts to increase the CNS gabaergic function of patients with schizophrenia.
D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors*; D000284:Administration, Oral; D000328:Adult; D000614:Aminocaproates / Q000009:adverse effects / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012560:Schizophrenia, Catatonic / Q000188:drug therapy* / Q000523:psychology; D012562:Schizophrenia, Disorganized / Q000188:drug therapy* / Q000523:psychology; D020888:Vigabatrin
D000614:Aminocaproates; D000612:4-Aminobutyrate Transaminase; D020888:Vigabatrin
Effets du gamma-vinyl GABA per os dans cinq cas de schizophrénie hébéphréno-catatonique.