title: Pharmacokinetics of cefoperazone in normal subjects and patients with hepatosplenic schistosomiasis.
abstract: The pharmacokinetics of cefoperazone were studied and compared in four normal subjects and six patients with hepatosplenic schistosomiasis (HSS) with mild liver disease but marked portal hypertension. All subjects received a 2 g intravenous infusion of cefoperazone over 15 min. Although most pharmacokinetic parameters did not differ significantly between normal subjects and patients with HSS, the serum beta half-life of cefoperazone was longer in patients with HSS compared to normal subjects (3.0 h vs. 1.7 h). This demonstrates only mild impairment of excretion of cefoperazone in patients with HSS.
mesh_terms: D000328:Adult; D002438:Cefoperazone / Q000378:metabolism*; D005260:Female; D006801:Humans; D007700:Kinetics; D008109:Liver Diseases, Parasitic / Q000378:metabolism*; D008297:Male; D012552:Schistosomiasis / Q000378:metabolism*; D013158:Splenic Diseases / Q000378:metabolism*
chemical_list: D002438:Cefoperazone