Idiopathic hemochromatosis.
The incidence of this mendelian recessive trait is higher than previously estimated. Idiopathic hemochromatosis is associated with certain HLA types. Early diagnosis and institution of a phlebotomy program can produce regression of all manifestations except hepatoma and arthritis. Screening, with determination of transferrin saturation greater than 60 percent, permits diagnosis before signs and symptoms appear. Serum ferritin determination is the best indicator of the course of the disease.
D001815:Bloodletting; D005260:Female; D005293:Ferritins / Q000097:blood; D006680:HLA Antigens / Q000235:genetics; D006432:Hemochromatosis / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy; D006801:Humans; D007501:Iron / Q000097:blood; D008297:Male; D008403:Mass Screening; D012880:Skin Pigmentation; D014168:Transferrin / Q000097:blood
D006680:HLA Antigens; D014168:Transferrin; D005293:Ferritins; D007501:Iron