1,2,3-Triazole derivatives of salicylic acid.
This paper describes the preparation of 1,2,3-triazole derivatives of salicylic acid from the methyl 4-azidosalicylate, by 1,3-dipolar cycloaddition reactions to beta-ketoesters, beta-ketoamides, beta-diketones and to symmetrical or asymmetrical alkynes. Other derivatives were obtained by hydrolysis and decarboxylation reactions. Some compounds were evaluated for antiinflammatory activity by an in vitro test based upon the inhibition of the cyclooxygenase enzyme, but they generally showed a weak activity.
D001792:Blood Platelets / Q000187:drug effects; D006801:Humans; D008315:Malondialdehyde / Q000097:blood; D012459:Salicylates / Q000138:chemical synthesis* / Q000494:pharmacology
D012459:Salicylates; D008315:Malondialdehyde