The monoclonal antibody A2B5 is specific to ganglioside GQ1c.
The neural specific monoclonal antibody A2B5 was found to interact with GQ1c but not with Gq1b, nor did it interact with other glycolipids such as GM1, GD1a, GD1b, GT1a, GT1b and GA1. Since GQ1c is enriched in embryonic chicken brains but not in adult chicken brains, this antibody should be useful as a tool in assessing the role of GQ1c in neuronal maturation.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D000918:Antibody Specificity; D001921:Brain / Q000276:immunology / Q000378:metabolism; D002417:Cattle; D002642:Chick Embryo; D005732:Gangliosides / Q000096:biosynthesis / Q000276:immunology*; D006801:Humans; D012160:Retina / Q000276:immunology
D000911:Antibodies, Monoclonal; D005732:Gangliosides; C082014:tetrasialoganglioside GQ1c