Cortical infarction in rabbits with serum sickness following Cyclosporin A therapy.
Rabbits given acute serum sickness (ASS) and treated with Cyclosporin A (CyA) developed glomerular capillary thrombosis and cortical infarction. These lesions were associated with severe endothelial injury and platelet-fibrin-leucocyte thrombi. They were not seen in untreated rabbits with ASS, nor in normal rabbits given CyA alone in equivalent doses. A similar renal lesion has been reported in patients receiving CyA following bone marrow transplantation.
D000818:Animals; D003524:Cyclosporins / Q000633:toxicity*; D005260:Female; D007238:Infarction / Q000139:chemically induced*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007672:Kidney Cortex / Q000098:blood supply*; D011817:Rabbits; D012713:Serum Sickness / Q000188:drug therapy*
D003524:Cyclosporins