Clinical and laboratory evaluation of praziquantel in opisthorchiasis.
A total of 122 patients were treated with a single dose of praziquantel 40 mg per kilogramme body weight, with 96 patients completing the follow up period of 60 days. The parasitological cure rate was 95.8% by single faecal examination. These patients had mild clinical manifestations. The hematological, biochemical and the liver function tests were within the normal limits. High eosinophilia was observed in 84.5% but there were no significant difference after eradication of the flukes. No significant changes were observed in the laboratory investigation at day 60 post treatment.
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007546:Isoquinolines / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009889:Opisthorchiasis / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D011223:Praziquantel / Q000494:pharmacology / Q000627:therapeutic use*
D007546:Isoquinolines; D011223:Praziquantel