[Alteration of the acute toxicity and various pharmacologic effects of streptomycin sulfate by calcium 4'-phosphopantothenate].
The effect of calcium 4'-phosphopantothenate (CPP) on acute toxicity of streptomycin and the decrease by the antibiotic of the muscle working capacity, "holes" reflex, body temperature and oxygen intake was studied on 258 albino mice weighing 22-26 g. Medical calcium pantothenate (CPA) was used for control purposes. CPP is an antagonist of streptomycin sulfate. In a dose of 1/10 or 1/5 of the LD50 injected intraperitoneally CPP lowered acute toxicity of streptomycin and prevented its effect in a dose of 0.11--1.1 g/kg injected subcutaneously on the muscle working capacity, "holes" reflex and body temperature. The spectrum index of the CPP antitoxic effect was equal to 22.5. By its acute toxicity CPP (LD50 1.18 +/- 0.07 g/kg) did not differ from CPA (LD50 1.25 +/- 0.08 g/kg). The efficacy of CPP, by its antitoxic spectrum, was 1.8 times higher than that of CPA. CPA lowered the streptomycin effect on the "holes" reflex and body temperature, while CPP prevented it. Both the drugs did not influence the decrease in the oxygen consumption induced by streptomycin.
D000208:Acute Disease; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D009132:Muscles / Q000187:drug effects; D009949:Orientation / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D012018:Reflex / Q000187:drug effects; D013307:Streptomycin / Q000037:antagonists & inhibitors* / Q000506:poisoning
D010205:Pantothenic Acid; C011988:phosphopantothenic acid; D013307:Streptomycin
Izmenenie ostroĭ toksichnosti i nekotorykh farmakologicheskikh éffektov streptomitsina sul'fata 4'-fosfopantotenatom kal'tsiia.