The dissolution and bioavailability of rifampicin products in healthy subjects and tubercular patients.
Dissolution test of two rifampicin (RFP) products (DI and CB) was carried out by "Rotating Basket Method" on JP X, using a first and second fluid for disintegration test or a de-aerated water as dissolution medium. The dissolution ratios of the DI product in the second fluid and de-aerated water at 60 min are 72.0% and 95.0%, and the CB product ratios are 10.0% and 5.5% respectively. On their bioavailability parameters, the DI product showed higher C max and AUC value than CB, in both healthy subjects and tubercular patients, but did not show a statistically significant difference. Healthy subjects showed statistically significant high C max and AUC values as compared against tubercular patients, namely on C max of CB and DI products, and on AUC of CB and DI product.
D000328:Adult; D001682:Biological Availability; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000378:metabolism*; D012995:Solubility; D014397:Tuberculosis, Pulmonary / Q000378:metabolism*
D012293:Rifampin