title: [Reducing blood pressure with Dipyron (novaminsulfone sodium)].
abstract: A fall in systolic blood pressure without other symptoms of anaphylactic shock has been described following the administration of drugs containing dipyrone. This adverse reaction was first observed in 4 patients by the same team in 1972-1973. Ten further cases with a fall in systolic blood pressure by at least 20 mm Hg occurring within minutes to 6 hours after intravenous administration of dipyrone are presented in this paper. In each of them this adverse reaction was considered to be probable or even definite. During the years 1976-1981 drug exposure was registered for all 15 678 patients of the two medical divisions of Comprehensive Hospital Drug Monitoring Berne. This adverse reaction was found in 7, representing 0.34% of the 2053 patients who received intravenous treatment with a dipyrone preparation.
mesh_terms: D000368:Aged; D000632:Aminopyrine / Q000031:analogs & derivatives*; D001794:Blood Pressure / Q000187:drug effects*; D004177:Dipyrone / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013599:Systole; D013997:Time Factors
chemical_list: D000632:Aminopyrine; D004177:Dipyrone
vernacular_title: Blutdruckabfall unter Dipyron (Novaminsulfon-Natrium).