[Cellular sensitization to fetal antigens during chemical carcinogenesis].
Tumor-bearing mice show a cellular sensitization to fetal antigens as detected by the macrophage electrophoretic mobility (MEM) test. Sensitization is independent of etiological and histological tumor factors. An identical state of sensitization can be found after application of chemical carcinogens (N-methyl-N-nitrosourea, benz(a)pyrene or 7,12-dimethylbenz(a)anthracene) before the tumors have developed. The results indicate that the effect is dose-dependent.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology*; D008262:Macrophage Activation; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000276:immunology*
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D002273:Carcinogens
Zelluläre Sensibilisierung gegen Fötalantigene während der chemischen Kanzerogenese.