Sublingual absorption of the quaternary ammonium antiarrhythmic agent, UM-272.
UM-272 (N,N-dimethylpropranolol), a quaternary antiarrhythmic agent, was administered sublingually to dogs with ouabain-induced ventricular tachycardias. Both anti-arrhythmic efficacy and bioavailability were compared to oral drug. Sublingual UM-272 converted ventricular tachycardia to sinus rhythm in all 5 dogs. The area under the plasma concentration time curve at 90 min was 4-12 times greater than for oral drug, suggesting the existence of an absorption-limiting process in the intestine, and providing an alternate form of administration for quaternary drugs.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000378:metabolism*; D004285:Dogs; D007408:Intestinal Absorption; D008297:Male; D010042:Ouabain / Q000494:pharmacology; D011433:Propranolol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D014059:Tongue
D000889:Anti-Arrhythmia Agents; D010042:Ouabain; C002616:pranolium; D011433:Propranolol