Pharmacokinetics of moxalactam in anuric children and during hemodialysis.
Pharmacokinetics of moxalactam were determined in children with chronic renal failure during a 4-hour hemodialysis or an interdialytic period following a 50 mg/kg dose. Mean elimination half-life during dialysis was 3.9 hours compared to 12.9 hours during the interdialytic period. Mean clearance of moxalactam was 86 ml/minute during hemodialysis and 25 ml/minute between dialysis. Mean dialyzer clearance of moxalactam was 45 ml/minute. The mean fraction of moxalactam removed during a 4-hour hemodialysis was 18% in nine children. In anuric children, a 50 mg/kg dose of moxalactam should be given every 48 hours in an interdialytic period and a 25 mg/kg dose given after each dialysis.
D000293:Adolescent; D000328:Adult; D001002:Anuria / Q000378:metabolism* / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D006207:Half-Life; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000628:therapy; D007700:Kinetics; D009070:Moxalactam / Q000008:administration & dosage / Q000378:metabolism*; D012044:Regression Analysis; D006435:Renal Dialysis
D009070:Moxalactam