title: Genetic and developmental characteristics of the homeotic mutation bx1 of Drosophila.
abstract: The mutations at the bithorax locus produce a transformation of anterior haltere into anterior wing. The bx1 allele presents unusual features when compared with other bx alleles. The phenotype of bx1 homozygotes is temperature sensitive but only with regard to the distal and not to the proximal transformation, thus suggesting two different components in the bithorax transformation. The phenotype of bx1 homozygotes is stronger than that of bx1 over the deletion of the gene, suggesting a trans interaction of the bx1 chromosomes which results in mutual partial inactivation. We show by temperature shift and clonal analysis experiments that the decision on whether to differentiate haltere or wing structures is taken at the end of the proliferation period of the mutant disc.
mesh_terms: D000483:Alleles; D000818:Animals; D004330:Drosophila / Q000235:genetics*; D005786:Gene Expression Regulation; D009154:Mutation; D010641:Phenotype; D013696:Temperature; D014170:Transformation, Genetic; D014921:Wings, Animal / Q000254:growth & development*