Development and characterization of a new murine renal tumor model. Chemotherapeutic results.
A murine renal cell carcinoma model, the RC tumor, was pharmacologically and histologically characterized and was used for the evaluation of 20 chemotherapeutic agents. This model, when implanted IP or SC showed reproducible behavior and was found to be very sensitive to many drugs with different mechanisms of action, and particularly to alkylating agents. The IP-implanted tumor was sensitive to some clinically active drugs which were reported inactive against L1210 or P388 murine leukemias. The highest sensitivity of this model than of L1210 and P388 leukemias makes the RC tumor a good prescreening system for testing potential chemotherapeutic agents.
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000648:ultrastructure; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical / Q000379:methods*; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000648:ultrastructure; D051379:Mice; D008815:Mice, Inbred Strains
D000970:Antineoplastic Agents