Dopamine release from the porcine myocardium.
Dopamine is a catecholamine with profound influence on cardiac function and known to be present in adrenergic nerve terminals as a precursor of noradrenaline. However, no previous study has examined whether dopamine is produced by myocardial tissue. During stable hemodynamic conditions in 13 young, thoracotomized pigs with the heart in situ, we found a net release of dopamine into the coronary sinus amounting to 1.39 +/- 0.36 ng/min X 100 g of left ventricular muscle mass (p less than 0.01). Dopamine was released from the myocardium whether the v-a difference for noradrenaline was positive or negative. This observation indicates a release of dopamine from the heart independent of sympathetic noradrenergic activity. Regulation of myocardial dopamine release remains unknown.
D000818:Animals; D001794:Blood Pressure; D003326:Coronary Circulation; D004298:Dopamine / Q000378:metabolism*; D004837:Epinephrine / Q000378:metabolism; D005260:Female; D006321:Heart / Q000502:physiology*; D006439:Hemodynamics; D008297:Male; D008955:Models, Cardiovascular; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D010101:Oxygen Consumption; D011954:Receptors, Dopamine / Q000502:physiology; D013552:Swine
D011954:Receptors, Dopamine; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine