(E)-5-(2-Bromovinyl)-2'-deoxyuridine: a good substrate for mammalian pyrimidine nucleoside phosphorylases.
Specific antiherpetic thymidine analogues are split by mammalian pyrimidine nucleoside phosphorylases with the following order of activity: VUdR greater than BVUdR greater than thymidine greater than EtUdR.
D000818:Animals; D001973:Bromodeoxyuridine / Q000031:analogs & derivatives* / Q000378:metabolism; D002286:Carcinoma, Ehrlich Tumor / Q000201:enzymology; D006801:Humans; D008099:Liver / Q000201:enzymology; D051379:Mice; D010430:Pentosyltransferases / Q000378:metabolism*; D057845:Pyrimidine Phosphorylases; D013154:Spleen / Q000201:enzymology; D013939:Thymidine Phosphorylase / Q000378:metabolism
C020235:brivudine; D010430:Pentosyltransferases; D057845:Pyrimidine Phosphorylases; D013939:Thymidine Phosphorylase; D001973:Bromodeoxyuridine