title: [Elastofibroma dorsi. A contribution to its morphology and pathogenesis].
abstract: For the time being it is generally accepted that elastofibroma is a mesenchymal, pseudotumorous hyperplasia. A great amount of a fibrillar and globular material is characteristical in the proliferated connective tissue, which has a high affinity to elastica dyes. These typical structures in the extracellular space are interpreted by various authors as elastotic degenerative collagen, degeneratively changed elastic fibers, or as newly synthetized elastin. The case of an elastofibroma is reported which was investigated by means of light microscopy, electron microscopy and histochemistry. With histochemical methods the peculiar material of the extracellular space was identified as elastin. Light- and electron microscopically, there were no relations to collagen fibers. The observations of sinus-like extended vessels support the idea of the pathogenic importance of a vascular alteration. The relations between the damage of vessels, the proliferation of fibroblasts, and the special synthesis of elastin are discussed.
mesh_terms: D000368:Aged; D001415:Back; D005110:Extracellular Space / Q000648:ultrastructure; D005260:Female; D005350:Fibroma / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D008854:Microscopy, Electron; D012878:Skin Neoplasms / Q000209:etiology / Q000473:pathology* / Q000648:ultrastructure
vernacular_title: Elastofibroma dorsi. Beitrag zur Morphologie und Pathogenese.