Information transfer in biological systems. Part II: Transfer of molecular information through biological membranes. The "reverse-translation".
A theory based on the fluid-mosaic-membrane model is presented to account for the transduction of extracellular molecular information into cells. Binding of a ligand to the external surface of the lipoprotein membrane leads to a specific rearrangement of the intracellular receptor-analogs or to a characteristic deformation of the inner membrane surface and these changes trigger further intracellular events. The saturated and unsaturated fatty acid chains in the membrane have important roles in transferring the extracellular molecular informations. Some similarities between the effects of monoamines, oligo- and polypeptides may be explained on the basis of this model. As a consequence of the model the possible existence of "reverse-translation" is suggested.
D000596:Amino Acids / Q000502:physiology; D000818:Animals; D001679:Biogenic Amines / Q000502:physiology; D002462:Cell Membrane / Q000502:physiology*; D006801:Humans; D007257:Information Theory; D046911:Macromolecular Substances; D008563:Membrane Lipids / Q000502:physiology; D008954:Models, Biological; D010455:Peptides / Q000502:physiology
D000596:Amino Acids; D001679:Biogenic Amines; D046911:Macromolecular Substances; D008563:Membrane Lipids; D010455:Peptides