title: [Analysis of a case of multiple myeloma with late dissemination of skin nodules].
abstract: A case of a 55 years old woman suffering from multiple myeloma with strong bone marrow proplasmocytic infiltration, several osteolytic and osteoporotic lesions and high seric M-component level and hypertensive heart failure is described. After 32 months of partial remission obtained with cyclic chemotherapy, large cutaneous tumors arose. Despite of a new therapeutic trial, in the last 8 months, an increase of bone marrow and seric signs was observed without involvement of the lungs or kidneys or expression of plasma-cell leukemia. Death occurred at 50th month because of sepsis and heart failure. A real cutaneous tropism, late occurred and without cytohistological changes, is stressed. The meaning of the rich vascularization of the skin over the tumors in absence of inflammation and necrosis remains unclear.
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology; D007074:Immunoglobulin G; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy; D012878:Skin Neoplasms / Q000150:complications*; D013997:Time Factors; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D007074:Immunoglobulin G; D014750:Vincristine
vernacular_title: Analisi di un caso di mieloma multiplo con disseminazione nodosa cutanea tardiva.