title: Comparison in animal models of 18F-spiroperidol and 18F-haloperidol: potential agents for imaging the dopamine receptor.
abstract: Fluorine-18-labeled haloperidol and spiroperidol have been prepared by an exchange reaction using the corresponding non-labeled compound or the nitro analog. Studies in rats have shown that the distribution of labeled spiroperidol has a high striatum to cerebellum ratio which is not observed with haloperidol. A ratio of 10.66 +/- 1.6 is obtained two hours after administration of the 18F-spiroperidol. When 18F-spiroperidol was administered to a baboon and tomographic images obtained, the dopamine receptor rich areas were clearly visualized two hours after administration.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002090:Butyrophenones / Q000378:metabolism*; D005461:Fluorine; D006220:Haloperidol / Q000378:metabolism*; D010215:Papio; D011868:Radioisotopes; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000032:analysis*; D013134:Spiperone / Q000378:metabolism*
chemical_list: D002090:Butyrophenones; D011868:Radioisotopes; D011954:Receptors, Dopamine; D005461:Fluorine; D013134:Spiperone; D006220:Haloperidol