Salutary effects of anisodamine in murine traumatic shock.
Anisodamine, an alkaloid originally extracted from the Chinese herb Anisodus tanguticus, has been reported to possess beneficial actions in septic, superior mesenteric artery occlusion, and hemorrhagic shock. We have investigated its actions in traumatic shock in rats. Anisodamine (2.5 mg/kg) increased survival time from 1.4 +/- 0.2 h to 3.1 +/- 0.3 h (P less than 0.001) in traumatized rats with 50% of the drug-treated animals surviving at least 3.5 h. Drug treatment had no significant effect on plasma cathepsin D activity (12.0 +/- 2.3 vs 10.4 +/- 1.7; vehicle- vs drug-treated, respectively). However, plasma myocardial depressant factor accumulation was significantly blunted by anisodamine, 62 +/- 5 vs 41 +/- 5 U/ml (P less than 0.02), indicating that prevention of MDF formation may be one protective mechanism of this substance.
D000818:Animals; D002402:Cathepsin D; D002403:Cathepsins / Q000097:blood; D008297:Male; D009201:Myocardial Depressant Factor / Q000097:blood / Q000502:physiology; D051381:Rats; D012774:Shock, Traumatic / Q000188:drug therapy* / Q000401:mortality; D012991:Solanaceous Alkaloids / Q000627:therapeutic use*; D013997:Time Factors
D009201:Myocardial Depressant Factor; D012991:Solanaceous Alkaloids; C003922:anisodamine; D002403:Cathepsins; D002402:Cathepsin D