title: [Experimental and clinical studies of an ampicillin suppository (KS-R1) in pediatrics].
abstract: Absorption of ampicillin (ABPC) suppository (KS-R1) was good with the peak level of ABPC at 15 minutes and the continuous high level for 1 hour by the administration of about 10 approximately 18 mg/kg. About 40% of active form of administered ABPC was excreted into urine within 6 hours. KS-R1 at the dose of about 20-40 mg/kg/day divided into 3-4 times was very against acute respiratory tract infection by the treatment for 3-5 days. The effective rate was 94% in 35 cases. By the administration of KS-R1, group A Streptococcus, S. pneumoniae and H. influenzae were eradicated. After the insertion of KS-R1, weak diarrhea and the discharge of KS-R1 were observed in 2 cases and 3 cases, respectively. It was concluded that KS-R1 is very useful drug for the treatment of infections by ABPC sensitive organisms in place of the oral form of ABPC.
mesh_terms: D000208:Acute Disease; D000367:Age Factors; D000667:Ampicillin / Q000008:administration & dosage* / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D013488:Suppositories
chemical_list: D013488:Suppositories; D000667:Ampicillin