[14C]6-methoxy-1,2,3,4-tetrahydro-beta-carboline in retinal and other tissues after intravascular and intravitreal injections in mice and rats.
6-Methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeO-THBC) is a condensation product of 5-methoxytryptamine and formaldehyde. It possesses diverse biochemical and pharmacological properties and has been suggested to act as a neuromodulator. 6-MeO-THBC has been shown to occur in various tissues including the retina in animals and human beings. The present results show that the mouse and rat retina as well as other tissues take up 14C-labelled 6-MeO-THBC injected intravenously or intravitreally. The retinal concentrations show a prompt rise after the injection and significant levels are maintained after 2 days.
D000818:Animals; D002243:Carbolines / Q000008:administration & dosage / Q000378:metabolism*; D007211:Indoles / Q000378:metabolism*; D007267:Injections; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D012160:Retina / Q000378:metabolism*; D014018:Tissue Distribution; D014822:Vitreous Body
D002243:Carbolines; D007211:Indoles; C002272:6-methoxytryptoline