Effect of indomethacin on aloin and 1,8 dioxianthraquinone-induced production of prostaglandins in rat isolated colon.
The effect of aloin and 1,8 dioxyanthraquinone on the release of prostaglandin-like material (PG) from rat isolated colon has been investigated. Orally administered aloin and 1,8 dioxyanthraquinone stimulates PG production by subsequently isolated segments of colon. Indomethacin was able to prevent this increased production of PG. These results suggest that the laxative properties of aloin and 1,8 dioxyanthraquinone may depend, at least in part, on increased prostaglandin synthesis by the intestinal tissue.
D000284:Administration, Oral; D000818:Animals; D000880:Anthraquinones / Q000494:pharmacology*; D002400:Cathartics / Q000494:pharmacology*; D003106:Colon / Q000187:drug effects / Q000378:metabolism*; D004347:Drug Interactions; D004642:Emodin / Q000031:analogs & derivatives / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology*; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats
D000880:Anthraquinones; D002400:Cathartics; D011453:Prostaglandins; D004642:Emodin; C006457:alloin; D007213:Indomethacin; C004315:danthron