Postictal prolactin elevations in rats.
Electrically induced seizures were followed by temporary elevations in serum prolactin over baseline in rats, while electrical irritation made no change. Naloxone 4 mg/kg i.p. pretreatment preserved this pattern but attenuated all levels including baseline by about 50%. While atropine 0.1 mg/kg s.c. did not change baseline levels, the prolactin levels after electrical irritation without seizure were about the same as those following a genuine seizure; atropine apparently facilitated stress-induced prolactin release. Seizures did not raise post-haloperidol prolactin levels above their high baseline levels.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004558:Electric Stimulation; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D011388:Prolactin / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000097:blood*
D009270:Naloxone; D001285:Atropine; D011388:Prolactin; D006220:Haloperidol