title: Rotational behavior following cholinergic stimulation of the superior colliculus in rats.
abstract: Rate which received microinjections of carbachol into the superior colliculus exhibited pronounced dose-dependent rotational behavior contralateral to the site of injection (Experiment 1). Wet dog shakes were also observed in some animals. Similar injections in the midbrain reticular formation produced immobility with slight contralateral flexion of the neck. Convulsions were observed in some rats after injections into either anatomical location. In Experiment 2, circling induced by carbachol in the superior colliculus was blocked by prior injection of either the muscarinic receptor antagonist scopolamine or the nicotinic receptor antagonist mecamylamine, suggesting that both nicotinic and muscarinic receptors are involved in the effect. In Experiment 3 contralateral rotational behavior was induced by intracollicular microinjections of the combination of acetylcholine chloride and physostigmine. The results suggest that collicular mediation of contralateral rotational behavior, and perhaps orientation, might involve cholinergic receptors.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology*; D002217:Carbachol / Q000494:pharmacology*; D005260:Female; D007839:Functional Laterality; D008297:Male; D008464:Mecamylamine / Q000494:pharmacology; D009949:Orientation / Q000502:physiology; D010830:Physostigmine; D051381:Rats; D011950:Receptors, Cholinergic / Q000502:physiology*; D012154:Reticular Formation / Q000502:physiology; D012399:Rotation; D012601:Scopolamine / Q000494:pharmacology; D013477:Superior Colliculi / Q000502:physiology*
chemical_list: D011950:Receptors, Cholinergic; D008464:Mecamylamine; D002217:Carbachol; D010830:Physostigmine; D012601:Scopolamine; D000109:Acetylcholine