[Perfusion of the ischemic myocardium in the acute phase of a myocardial ischemia using a stroma-free hemoglobin solution].
Concerning the effect of the perfusion of ischemic areas of the myocardium by a stroma-free hemoglobin solution was reported after the starvation of the interventricular branch of the left coronary artery (RIVA) in minipigs. The effect of the perfusion is dependent on the kind of the vascular course. The perfusion of the distal part of the starvated coronary artery shows the better reaction in face of the artemalization of the concomitant cardiac vein with regard to the resaturation of the myocardium with oxygen and several hemodynamic control parameters. Histologic examinations of the ischemic myocardium after the arterialization of the cardiac veins showed however that the symplasm preserved its vitality and showed only reversible changes. The applied stroma-free hemoglobin solution needs a further development. However, the use is possible on principle according to the bibliography. Whether a new clinical therapy could be developed by a transitory arterialization of the cardiac veins in acute myocardial ischemia, should be discussed.
D000818:Animals; D001802:Blood Substitutes / Q000008:administration & dosage*; D004195:Disease Models, Animal; D005260:Female; D006439:Hemodynamics; D006454:Hemoglobins / Q000008:administration & dosage*; D008297:Male; D009203:Myocardial Infarction / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D009206:Myocardium / Q000378:metabolism; D010100:Oxygen / Q000378:metabolism; D010313:Partial Pressure; D010477:Perfusion / Q000379:methods; D013552:Swine; D013556:Swine, Miniature
D001802:Blood Substitutes; D006454:Hemoglobins; D010100:Oxygen
Die Perfusion des ischämischen Myokards in der akuten Phase einer Myokardischämie mittels einer stromafreien Hämoglobinlösung.