[Pyruvate and glucose transport through the erythrocyte membranes and the role of spectrin in these processes].
Effect of antibody to peripheral protein spectrin and antibody to integral protein of band 3 on kinetic parameters of pyruvate and glucose transport in the pink erythrocyte ghosts has been studied. It is shown that spectrin structure reorganization induced by the antibody to this protein has different effect on pyruvate and glucose transport parameters. Band 3 protein modification with the help of the antibody to this protein changes pyruvate transport parameters, while glucose transport is not changed. The data obtained show that facilitated diffusion of glucose and anions in the erythrocyte membrane is carried out by different carriers, the action of these carriers essentially depending on the structure state of spectrin.
D001457:Anion Exchange Protein 1, Erythrocyte / Q000378:metabolism; D001693:Biological Transport, Active; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D011773:Pyruvates / Q000097:blood*; D019289:Pyruvic Acid; D013049:Spectrin / Q000378:metabolism*
D001457:Anion Exchange Protein 1, Erythrocyte; D011773:Pyruvates; D013049:Spectrin; D019289:Pyruvic Acid; D005947:Glucose
Transport piruvata i gliukozy cherez éritrotsitarnye membrany i rol' spektrina v étikh protsessakh.