The effects of the stimulation of histamine-forming capacity (HFC) and the inhibition of histamine catabolism on tensile strength and collagen content of skin wounds in the rats.
The effects of histamine-forming capacity (HFC) stimulation by 48/80 as well as of histamine catabolism inhibition by aminoguanidine on the tensile strength and collagen production were studied in wounds of rats. 48/80 raised the level of collagen in wounds and increased their tensile strength. Aminoguanidine increased the histamine content of the wounds but markedly lowered the tensile strength and collagen content.
D000818:Animals; D003094:Collagen / Q000378:metabolism*; D006146:Guanidines / Q000627:therapeutic use; D006632:Histamine / Q000096:biosynthesis / Q000378:metabolism*; D006633:Histamine Antagonists; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000293:injuries* / Q000503:physiopathology; D013268:Stimulation, Chemical; D013718:Tensile Strength / Q000187:drug effects; D014945:Wound Healing / Q000187:drug effects; D014950:Wounds, Penetrating / Q000188:drug therapy / Q000503:physiopathology*; D003189:p-Methoxy-N-methylphenethylamine / Q000627:therapeutic use
D006146:Guanidines; D006633:Histamine Antagonists; D003189:p-Methoxy-N-methylphenethylamine; D006632:Histamine; D003094:Collagen; C004479:pimagedine