Fasciola hepatica: the flukicidal effect of some anaesthetics and analgesics in common use.
The anaesthetic halothane and the sedative xylazine were shown to have anthelmintic properties in rats against the liver fluke Fasciola hepatica. Flukes in rats treated with the local anaesthetic lignocaine or the anaesthetic/analgesic ketamine were unaffected.
D000769:Anesthesia, Inhalation; D000818:Animals; D000871:Anthelmintics; D005210:Fasciola hepatica / Q000187:drug effects*; D005211:Fascioliasis / Q000469:parasitology*; D006221:Halothane / Q000494:pharmacology*; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D007649:Ketamine / Q000494:pharmacology*; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013843:Thiazines / Q000494:pharmacology*; D014991:Xylazine / Q000494:pharmacology*
D000871:Anthelmintics; D013843:Thiazines; D014991:Xylazine; D007649:Ketamine; D008012:Lidocaine; D006221:Halothane