[Inhibition of bone tissue formation by propane-2,2-diphosphonate].
Among other diphosphonates here described propane-2,2-diphosphonate displays specific effects on bone-turnover. In contrast to other diphosphonates propane-2,2-diphosphonate inhibits especially different enzymes of growing bone and therefore inhibits formation of bone. The indication for the clinical use follows from that effect: pathologic states with increased bone formation may be treated by application of propane-2,2-diphosphonate.
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects; D004164:Diphosphonates / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008855:Microscopy, Electron, Scanning; D008903:Minerals / Q000378:metabolism; D010012:Osteogenesis / Q000187:drug effects*; D011817:Rabbits
D004164:Diphosphonates; D008903:Minerals; C039738:propane-2,2-diphosphonic acid
Hemmung de Knochengewebsbildung durch Propan-2,2-diphosphonat.