title: Tunicamycins, streptovirudins, and corynetoxins, a special subclass of nucleoside antibiotics.
abstract: Tunicamycins, streptovirudins, and very recently, corynetoxins have been determined to be structurally related nucleoside antibiotics. Because of their special biological activity as inhibitors of protein glycosylation and their relatively complicated chemical structures, which differ from the common nucleoside antibiotics, they can be grouped together as a special subclass. A general specification system based on structural characteristics is included. The complete separation of the natural complex is still problematical, but seems to be necessary because differences in the biological activities of the individual components were observed.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D005944:Glucosamine / Q000031:analogs & derivatives*; D006017:Glycolipids / Q000494:pharmacology*; D011741:Pyrimidine Nucleosides; D014415:Tunicamycin / Q000494:pharmacology*; D014498:Uracil
chemical_list: D000900:Anti-Bacterial Agents; D006017:Glycolipids; D011741:Pyrimidine Nucleosides; C034696:corynetoxins; D014415:Tunicamycin; C009329:streptovirudin; D014498:Uracil; D005944:Glucosamine