title: A study of the routine use of the Imugard IG500 Leukocyte Removal Filter illustrating a possible cause of transfusion reactions and a method of prevention.
abstract: The results of the use of the Imugard IG500 Leukocyte Removal Filter in the transfusion of 100 patients requiring leucocyte poor blood are presented. The patients were suffering from a variety of disorders. Many of them had previously received leucocyte poor blood prepared by other methods. Five patients developed non-haemolytic transfusion reactions. Subsequent investigations suggested that these were reactions to the plasma proteins present in the leucocyte poor blood prepared by filtration. A simple method of removal of these plasma proteins combined with filtration is described. The resultant product has been transfused, without incident, into the patients who previously reacted.
mesh_terms: D000756:Anemia, Sideroblastic / Q000276:immunology; D000920:Antibody-Dependent Cell Cytotoxicity; D002469:Cell Separation / Q000295:instrumentation*; D005260:Female; D005374:Filtration; D006801:Humans; D007962:Leukocytes; D008297:Male; D009196:Myeloproliferative Disorders / Q000276:immunology / Q000628:therapy; D013789:Thalassemia / Q000276:immunology / Q000628:therapy; D065227:Transfusion Reaction