Quinidine induced sicca syndrome.
Two weeks after initiation of therapy with 1.2 gm/day quinidine sulphate, a 67 year old patient developed clinical and laboratory features of sicca syndrome. These subsided upon discontinuation of the treatment, but reappeared on a second challenge with this drug. Sicca syndrome represents a previously undescribed hypersensitivity reaction to quinidine.
D000368:Aged; D004342:Drug Hypersensitivity / Q000503:physiopathology; D006801:Humans; D008297:Male; D011802:Quinidine / Q000009:adverse effects*; D012859:Sjogren's Syndrome / Q000139:chemically induced* / Q000503:physiopathology
D011802:Quinidine