[Molecular mechanisms of the radioprotective action of benzothiadiazole derivatives].
The analysis was made of the relationship between the radioprotective efficiency of substituted benzothiadiazoles and their electronic characteristics. The protective effect of these substances was shown to correlate with their ability to participate in the electron transfer. It was established that the protective effect comes into play via the formation of metal complexes in which benzothiadiazole molecules are ligands. The protective effect increases with increasing energy of complex ligation and diffusion motility of the radioprotector molecules.
D000818:Animals; D004579:Electron Transport; D007928:Lethal Dose 50; D008024:Ligands; D008670:Metals; D051379:Mice; D011837:Radiation-Protective Agents / Q000633:toxicity; D013830:Thiadiazoles / Q000494:pharmacology* / Q000633:toxicity
D008024:Ligands; D008670:Metals; D011837:Radiation-Protective Agents; D013830:Thiadiazoles
Molekuliarnye mekhanizmy radiozashchitnogo deĭstvie proizvodnykh benzotiadiazolov.