[Plasma separation as an effective treatment of glomerulonephritis in lupus erythematosus].
Positive anti-DNA-antibodies and lowered C3 and C4 levels were found in serum of a 13 year old girl presenting with edema, microscopic hematuria and proteinuria. Renal biopsy revealed diffuse endo- and extracapillary glomerulonephritis with mesangial deposits of IgA, IgG, IgM, C1q, C3 and fibrinogen. In spite of treatment with prednisone (60 mg/m2/d) severe nephrotic syndrome (proteinuria greater than 20/d) developed with excessive hypertension and deterioration of renal function (GFR: 20 ml/min./1,73m2 BSA). Plasma exchange therapy (3 sessions) led to recovery of renal function, blood pressure and complement activity and to a reduction of anti-DNA-antibodies and protein excretion.
D000293:Adolescent; D001794:Blood Pressure; D003165:Complement System Proteins / Q000032:analysis; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology / Q000628:therapy*; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D009404:Nephrotic Syndrome / Q000209:etiology / Q000628:therapy; D010956:Plasmapheresis; D011507:Proteinuria
D003165:Complement System Proteins
Plasmaseparation als effektive Behandlung der Glomerulonephritis bei Lupus erythematodes.