[Uptake of gamma-aminobutyric acid and glutamate decarboxylase activity in synaptosomes of various regions of the brain of rats in adrenalectomy and in subsequent hydrocortisone administration].
The adrenalectomy in rats followed by a single hydrocortisone administration had no influence on the glutamate decarboxylase activity and maximum rate of [3H] GABA uptake by synaptosomes of hypothalamus, hippocampus and cerebral hemispheres. Km of [3H] GABA uptake by synaptosomes in the above mentioned brain regions under adrenalectomy decreases sharply; hydrocortisone administration increases Km of mediator uptake by hippocampus synaptosomes, and hydrocortisone in vitro increases Km of [3H] GABA uptake by hypothalamus synaptosomes.
D000315:Adrenalectomy; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology*; D007031:Hypothalamus / Q000378:metabolism; D007700:Kinetics; D008297:Male; D009928:Organ Specificity; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D005968:Glutamate Decarboxylase; D006854:Hydrocortisone
Zakhvat gamma-aminomaslianoĭ kisloty i aktivnost' glutamatdekarboksilazy v sinaptosomakh razlichnykh otdelov mozga krys pri adrenaléktomii i posleduiushchem vvedenii gidrokortizona.