Alterations in sex-steroid hormone receptors during mammary gland differentiation in the rat.
Sprague-Dawley and Wistar strains were the best tissue sources for the estrogen receptors of the mammary gland of 7 rat strains examined. Tissue DNA content reached a maximum in late lactation (15-19 days). Cytosolic protein concentrations reached a maximum in late lactation (15-19 days). Both tissue DNA and cytosolic protein concentrations decreased upon weaning. The dissociation constant of the cytosolic estrogen receptor showed little change in pregnancy and lactation. The cytosolic estrogen receptor concentration was maximal at 19 days lactation. The cytosolic protesterone receptor was undetectable in late pregnancy (14-20 days) and in mid and late lactation (10-19 days).
D000818:Animals; D002454:Cell Differentiation; D003600:Cytosol / Q000378:metabolism; D004247:DNA / Q000032:analysis; D005260:Female; D007700:Kinetics; D007774:Lactation; D008321:Mammary Glands, Animal / Q000196:embryology / Q000254:growth & development* / Q000378:metabolism; D011247:Pregnancy; D011506:Proteins / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D011960:Receptors, Estrogen / Q000378:metabolism*
D011506:Proteins; D011960:Receptors, Estrogen; D004247:DNA