The effects of atropine and secoverine on gastric secretion and motility in the mouse isolated stomach.
The isolated perfused stomach of the mouse was used to study the effect of atropine and secoverine on bethanechol-induced gastric acid secretion and gastric motility. Both atropine and secoverine inhibited cholinergically induced gastric acid secretion and gastric motility. Inhibition of gastric acid secretion by atropine and secoverine occurred at a similar dose-range (10(-9) and 2 X 10(-9) M). Secoverine inhibited bethanechol-induced hypermotility at doses (10(-11) M and above) that were lower than those of atropine (2 X 10(-9) M and above) required to produce this effect. Secoverine, unlike atropine markedly inhibited gastric motility at lower doses than those which affected secretion.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010276:Parasympatholytics / Q000494:pharmacology*; D010627:Phenethylamines / Q000494:pharmacology*
D010276:Parasympatholytics; D010627:Phenethylamines; C028187:secoverine; D001285:Atropine