title: [Acute poisoning by viloxazine chlorhydrate taken by itself].
abstract: One of the missions of the Poison Control Centres is to collect an important number of cases concerning a substance in order to determine its toxicological pattern for man. Such data were collected for Viloxazine chlorhydrate, an antidepressant belonging to a new chemical, ingested without association with other drugs, at doses varying from 100 mg to 4 g. The toxicological action of this drug was moderate, as no death occurred in the cases under study. The depression of the central nervous system was characterised only by a transitory loss of consciousness with recovery within a few hours. Two cases of convulsive seizure and one of extrapyramidal syndrome were the only complications in these intoxications. This confirms the difference between viloxazine and other antidepressants (tricyclics or IMAO inhibitors) whose toxic action on C.N.S. is more pronounced and sometimes complicated by cardiovascular disorders.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003866:Depressive Disorder / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005602:France; D006801:Humans; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000506:poisoning*; D013405:Suicide / Q000453:epidemiology; D014745:Viloxazine / Q000506:poisoning* / Q000627:therapeutic use
chemical_list: D009025:Morpholines; D014745:Viloxazine
vernacular_title: Intoxications aiguës par le chlorhydrate de viloxazine pris isolément.