Quantitative analysis of ethchlorvynol in a capsule dosage form by NMR spectroscopy.
A quantitative 1H-NMR procedure is described for measuring ethchlorvynol in capsules. Deuterochloroform is used as the solvent, and hexamethylenetetramine as the internal standard; the analysis is based on the comparison of the area of the AB peak system of ethchlorvynol with the area of the hexamethylenetetramine singlet. The 1H-NMR method yields results that are precise to within 1% and agree well with results of the more cumbersome and less specific USP titrimetric procedure.
D002214:Capsules / Q000032:analysis; D004984:Ethchlorvynol / Q000032:analysis*; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D012995:Solubility
D002214:Capsules; D004984:Ethchlorvynol