Induction of IgE-isotype specific tolerance by passive antigenic stimulation of the respiratory mucosa.
Repeated exposure of high IgE-responder BN rats to an aerosol of ovalbumin (OVA) induced tolerance which was specific both for the antigen and the IgE antibody class. Radiotracer studies with 125I-OVA indicated that inhaled antigen doses in the low microgram range were tolerogenic, the bulk of the inhaled antigen being distributed 2:1 between the gastro-intestinal and respiratory tracts. Subsequent gastric intubation studies showed that the gastric component did not contribute to tolerance induction, suggesting that antigenic stimulation of the respiratory mucosa was central to this process.
D000336:Aerosols; D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D005260:Female; D007108:Immune Tolerance; D007126:Immunoglobulin Allotypes / Q000096:biosynthesis; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis; D008297:Male; D009092:Mucous Membrane / Q000276:immunology; D010047:Ovalbumin / Q000008:administration & dosage / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D012137:Respiratory System / Q000276:immunology*; D014018:Tissue Distribution
D000336:Aerosols; D000941:Antigens; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D007073:Immunoglobulin E; D010047:Ovalbumin