On the specificity of the two forms of human serum alpha-L-fucosidase.
All normal sera exhibiting either normal or low activities contain two forms of alpha-L-fucosidase (F1 and F2). These two forms, isolated from either type of serum, have respectively similar properties, but the low-activity sera contain a major proportion of the thermolabile, less-acidic form, F1. The specificities for natural substrates (glycoproteins and oligosaccharides) and for synthetic fucosides have been studied. All types of alpha-L-fucosidase linkages (1,2; 1,3; 1,4 and 1,6) are split by the form F2. The specificity of the form F1 is more restricted. Only alpha(1,3) and some types of alpha(1,2) and alpha(1,4) fucosyl linkages are split.
D002236:Carbohydrate Conformation; D004355:Drug Stability; D005643:Fucose / Q000378:metabolism; D006358:Hot Temperature; D006801:Humans; D009844:Oligosaccharides / Q000378:metabolism; D013329:Structure-Activity Relationship; D013379:Substrate Specificity; D005644:alpha-L-Fucosidase / Q000097:blood* / Q000302:isolation & purification
D009844:Oligosaccharides; D005643:Fucose; D005644:alpha-L-Fucosidase