Single-strand breaks in DNA of various organs of mice induced by styrene and styrene oxide.
Styrene and its metabolite styrene oxide were given i.p. to mice. The induction of single-strand breaks (SSB) in DNA was studied with the DNA unwinding technique. The level of SSB in kidney-DNA was a linear function of the dose for both substances. Styrene and styrene oxide induced an increase in the level of SSB in DNA of kidney, liver, lung, testis and brain 1 h after administration. After 24 h the damage remained on an enhanced level in liver, lung and testis after styrene oxide administration and in all organs except liver after styrene administration.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004852:Epoxy Compounds / Q000494:pharmacology*; D004988:Ethers, Cyclic / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D051379:Mice; D013343:Styrenes / Q000494:pharmacology*; D013737:Testis / Q000378:metabolism; D013997:Time Factors
D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D013343:Styrenes; D004247:DNA; C013690:styrene oxide