[Toxicity and radio-protective properties of pyridazine derivatives].
In experiments in irradiated (CBA X S57B1)F1 mice a study was made of toxicity and radioprotective efficiency of some pyridazine and pyridazine dione derivatives. Some of these substances were shown to have a moderate protective action when administered intraperitoneally. A correlation was revealed between the chemical structure and the radioprotective properties of the compounds.
D000818:Animals; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011724:Pyridazines / Q000494:pharmacology* / Q000633:toxicity; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents; D013329:Structure-Activity Relationship
D011724:Pyridazines; D011837:Radiation-Protective Agents
Toksichnost' i radiozashchitnye svoĭstva proizvodnykh piridazina.