Deficits in cholinergic enzymes and muscarinic receptors in the hippocampus and striatum of senescent rats: effect of chronic hydergine treatment.
Choline acetyltransferase and acetylcholine esterase activities in the hippocampus and striatum were significantly decreased in senescent (26-36 mo.) rats as compared with adult (11-12 mo.) animals. A significant reduction in 3H-QNB binding sites was also observed in the striatum from aged rats whereas in the hippocampus these binding sites were not influenced by age. A four week treatment of aged animals with Hydergine resulted in an increase in choline acetyltransferase activity so that the age-dependent deficit was no longer apparent.
D000110:Acetylcholinesterase / Q000378:metabolism; D000375:Aging; D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004088:Dihydroergotoxine / Q000494:pharmacology*; D005260:Female; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010275:Parasympathetic Nervous System / Q000201:enzymology*; D011813:Quinuclidinyl Benzilate; D051381:Rats; D011976:Receptors, Muscarinic / Q000378:metabolism*
D011976:Receptors, Muscarinic; D004088:Dihydroergotoxine; D011813:Quinuclidinyl Benzilate; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase