Long-lasting reduction in ethanol selection after involuntary intake of ethanol/chlordiazepoxide.
C57BL/6J mice, after having been exposed to a free-choice condition between water and aqueous chlordiazepoxide (CDP, 25 mg/100 ml) or between water and ethanol/CDP, showed a significant trend for decreased preference for ethanol when tested 2 weeks later. Similarly, mice previously exposed to a no-choice intake of ethanol showed a significant decrease in ethanol preference when tested subsequently. A long-lasting (greater than 20 weeks) reduction in ethanol selection developed after mice were previously exposed to ethanol/CDP in a no-choice condition. This was also accompanied by a decrease in the subsequent selection of ethanol/CDP, but not CDP. The exact mechanisms for the long-lasting decrease in ethanol selection was unknown, but it was not due to the development of fluid aversion. It is suggested that the combined central effects of ethanol/CDP might be partially responsible.
D000428:Alcohol Drinking; D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004327:Drinking Behavior / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology*; D005518:Food Preferences / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D014867:Water
D014867:Water; D000431:Ethanol; D002707:Chlordiazepoxide