[Effect of M-and N-cholinolytics on the content of Ca2+ in synaptosomes and metabolism of phosphoinositols in the rat brain].
M-cholinolytics benactyzine and glypine increased a permeability of neurone membranes for Ca2+, producing the ion accumulation in synaptosomes. N-cholinolytic thropacin did not exhibit this effect and diphacyl caused similar to the M-cholinolytics but only slight effect on the Ca2+ content. The M-cholinolytics increased phosphoinositol turnover in rat brain, while the N-cholinolytics decreased its metabolism. These data obtained suggest that the M-cholinolytics interact selectively with phosphoinositols of neurone membranes affecting the affinity of phosphoinositols to two-valent cations and elevating the ability of Ca2+ to penetrate across neuronal membranes.
D000818:Animals; D001535:Benactyzine / Q000494:pharmacology*; D001921:Brain / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000187:drug effects; D008297:Male; D010276:Parasympatholytics / Q000494:pharmacology*; D010716:Phosphatidylinositols / Q000378:metabolism*; D051381:Rats; D013329:Structure-Activity Relationship; D013570:Synaptic Membranes / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*; D014326:Tropanes / Q000494:pharmacology*
D010276:Parasympatholytics; D010716:Phosphatidylinositols; D014326:Tropanes; C026280:glipin; D001535:Benactyzine; D002118:Calcium
Vliianie M- i N-kholinolitikov na soderzhanie Ca2+ v sinaptosomakh i obmen fosfoinozitidov v golovnom mozge krys.