Assessment of skeletal uptake of 99mTc-diphosphonate over a five day period.
A new method for the sequential monitoring of skeletal uptake of 99mTc-diphosphonate over a 5-day period, utilising both a gamma camera and whole-body monitor, is presented. It has been found that diphosphonate continues to be removed from bone over this period. Normal subjects appear to lose skeletal activity initially at a more rapid rate than those with altered skeletal metabolism and it is suggested that differences in binding characteristics may exist.
D001859:Bone Neoplasms / Q000175:diagnosis; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism*; D004164:Diphosphonates / Q000378:metabolism*; D006801:Humans; D010001:Osteitis Deformans / Q000175:diagnosis; D010024:Osteoporosis / Q000175:diagnosis; D011877:Radionuclide Imaging; D013667:Technetium / Q000378:metabolism*; D017556:Technetium Compounds
D004164:Diphosphonates; D017556:Technetium Compounds; D013667:Technetium; C029045:technetium Tc 99m diphosphonate