[Pharmacoclinical comparison of 2 dosage forms of trihexyphenidyl].
The peak plasma level of Trihexyphenidyl sustained release from (THR = Parkinane sustained release) is lower than that produced by the simple form (THS = Artane) while it provides a quantitatively equivalent serum concentration. The less noticeable with sustained release Trihexyphenidyl. THR plasma levels, maintained relatively constant by a progressive release of the active principle, are sustained over a 24-hour period, allowing a simplified mode of administration: the drug may be given once a day.
D000328:Adult; D001682:Biological Availability; D003692:Delayed-Action Preparations; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D014282:Trihexyphenidyl / Q000097:blood* / Q000627:therapeutic use
D003692:Delayed-Action Preparations; D014282:Trihexyphenidyl
Comparaison pharmacoclinique de deux formes galéniques de trihexyphénidyle.