[Correlation of lactate dehydrogenase activity and its isoenzyme composition in the liver and blood serum in experimental myocardial infarction].
After ligation of coronary artery an initial increase in LDH activity in liver tissue was followed by its decrease. Minimal enzymatic activity in liver tissue correlated with maximal activity in blood serum within 1-3 days. Among LDH isoenzymes the "pure" fractions were most markedly altered: LDH1 was decreased in liver tissue and increased in blood serum, LDH5 was increased in the both tissues within later periods after normalization of total activity. Enzymatic activity of LDH, LDH1 and LDH5 was shown to correlate in liver tissue and blood serum.
D000818:Animals; D004796:Clinical Enzyme Tests; D003331:Coronary Vessels / Q000502:physiology; D004195:Disease Models, Animal; D007527:Isoenzymes; D007700:Kinetics; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008297:Male; D009203:Myocardial Infarction / Q000201:enzymology*; D011817:Rabbits
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase
Vzaimosviaz' aktivnosti laktatdegidrogenazy i ee izofermentnogo sostava v pecheni i syvorotke krovi pri éksperimental'nom infarkte miokarda.