Synthesis and anticonvulsant testing of 4-phenylsemicarbazides.
A series of compounds based on the semicarbazide structure have been synthesized. Anticonvulsant activity was found in a majority of the compounds using both the maximal electroshock seizure and the subcutaneous pentylenetetrazol seizure threshold tests. Activity of the compounds was weaker than the 1,1,2-trisubstituted semicarbazides previously reported.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D004597:Electroshock; D008297:Male; D051379:Mice; D012663:Semicarbazides / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000927:Anticonvulsants; D012663:Semicarbazides