Tonotopic bands produced by tones commenced long after 2-deoxyglucose injection.
Presentation of two different tones at two different time periods each under two different types (14C or 3H) of 2-deoxyglucose (2-DG) produced two bands of labelling in the inferior colliculus (IC) of a guinea pig. Filtering tests revealed that both bands were produced by only one of the labels (14C). Four guinea pigs were given one injection of 2-DG and then stimulated with two tones, each presented at different time periods. Two bands of labelling were produced in IC, with one band being produced by tones given 55-90 min after injection. The implications of this long lasting effect of 2-DG are discussed for the general 2-DG model and for sequential double labelling experiments.
D000161:Acoustic Stimulation; D000818:Animals; D001345:Autoradiography; D003837:Deoxy Sugars / Q000008:administration & dosage*; D003847:Deoxyglucose / Q000008:administration & dosage* / Q000378:metabolism; D006168:Guinea Pigs; D007245:Inferior Colliculi / Q000378:metabolism*; D007267:Injections; D013997:Time Factors
D003837:Deoxy Sugars; D003847:Deoxyglucose