Fibrinogen "Haifa" - a new fibrinogen variant. A case report.
A 30-year-old female presenting with arterial occlusions of the lower limbs was discovered to have a markedly abnormal thrombin time and reptilase time. Further investigations revealed the presence of a qualitatively abnormal fibrinogen. Two other family members who were completely asymptomatic had similar defects. The abnormal fibrinogen has been characterized and found to be a new variant and as such designated fibrinogen 'Haifa'.
D000328:Adult; D003018:Clot Retraction; D005260:Female; D005263:Femoral Artery / Q000601:surgery; D005340:Fibrinogen / Q000235:genetics* / Q000276:immunology; D015241:Fibrinogens, Abnormal; D014644:Genetic Variation; D006801:Humans; D007383:Intermittent Claudication / Q000209:etiology / Q000235:genetics*; D011150:Popliteal Artery / Q000601:surgery; D013918:Thrombin Time
D015241:Fibrinogens, Abnormal; D005340:Fibrinogen