Studies on the binding of IgG and F(ab) anti-A to adult and newborn group A red cells.
The values of the functional affinity constants for the binding of human IgG anti-A and its F(ab) derivative with adult and newborn group-A red cells have been determined. The values obtained for both monovalent and bivalent antibody with both types of cells were of the same order (about 1 X 10(8) M-1), indicating that IgG anti-A binds to red cells only by one of its F(ab) arms.
D000017:ABO Blood-Group System / Q000276:immunology*; D000328:Adult; D000915:Antibody Affinity; D001666:Binding Sites, Antibody; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D007231:Infant, Newborn
D000017:ABO Blood-Group System; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G