[Pharmacokinetics of cephapirin sodium during intravenous infusion].
Studies on absorption and excretion of cephapirin (CEPR) are described. CEPR was administered by intravenous drip infusion to 4 healthy volunteers weighing 53 kg to 61 kg, and the serum levels were measured. Pharmacokinetic parameters were calculated by one-compartment model and two-compartment model. Each model was comparatively applied to every founds. Most appropriate administration rate of intravenous drip infusion was discussed due to calculated serum levels, therapeutic AUC and effective time.
D002511:Cephalosporins / Q000008:administration & dosage*; D002514:Cephapirin / Q000008:administration & dosage* / Q000097:blood / Q000652:urine; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics; D008954:Models, Biological; D013997:Time Factors
D002511:Cephalosporins; D002514:Cephapirin