title: Toxicity of rubber chemicals in the chicken embryo. How to interpret results from animal tests.
abstract: Results from 80 rubber chemicals in the chicken embryo test were reviewed and compared, when data were found, to results on teratogenicity in mammalian test systems. In addition other sources of literature were used to compare the chicken embryo test to the mammalian tests. Furthermore the results from animal models were analyzed in terms of their ability to predict teratogenicity in humans.
mesh_terms: D000014:Abnormalities, Drug-Induced; D000818:Animals; D002642:Chick Embryo / Q000187:drug effects*; D006801:Humans; D007928:Lethal Dose 50; D012408:Rubber / Q000633:toxicity*
chemical_list: D012408:Rubber