The role of a noradrenergic system in the antinociceptive effects of 4-aminopyridine in the rat.
Antinociceptive effects of physostigmine and 4-aminopyridine after i.p. administration were studied in rats according to the Randall-Selitto nociception method. The antinociceptive action of physostigmine was not significantly influenced by atropine, naloxone or alpha-methyl-p-tyrosine. The antinociceptive action of 4-aminopyridine was also unaffected by simultaneous administration of atropine, naloxone or pretreatment by DL-p-chlorophenylalanine. However, 4-aminopyridine was without antinociceptive effect in rats pretreated with alpha-methyl-p-tyrosine. It is suggested that the antinociceptive action of 4-aminopyridine is mediated by a noradrenergic system.
D015761:4-Aminopyridine; D000631:Aminopyridines / Q000494:pharmacology*; D000700:Analgesics; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D010830:Physostigmine / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000631:Aminopyridines; D000700:Analgesics; D002800:Cholinesterase Inhibitors; D010830:Physostigmine; D015761:4-Aminopyridine; D009638:Norepinephrine