Multiple keratoacanthomas possibly induced by psoralens and ultraviolet A photochemotherapy.
We report two patients who developed multiple keratoacanthomas while receiving photochemotherapy (PUVA). Both patients had received excessive doses of PUVA, which resulted in severe phototoxicity. The role of PUVA in the production of these lesions is discussed.
D000328:Adult; D006801:Humans; D007636:Keratoacanthoma / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011701:PUVA Therapy / Q000009:adverse effects*; D010778:Photochemotherapy / Q000009:adverse effects*; D011565:Psoriasis / Q000188:drug therapy; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology