Monocyte function in idiopathic nephrotic syndrome in childhood.
The monocyte function of 112 specimens from 42 children with idiopathic nephrotic syndrome (INS) aged from 2 to 17 years was studied by the methods of nitroblue tetrazolium (NBT) reduction, phagocytosis of immunobeads (IB) and yeast cells, chemotaxis and acid alpha-naphthyl acetate esterase (ANAE) staining. The dissociation between phagocytosis and chemotaxis was observed in the fresh cases of steroid sensitive INS and in the cases of steroid non-sensitive INS. In the fresh cases of steroid sensitive INS, NBT reduction and phagocytosis were increased, but chemotaxis was decreased. In the cases of steroid non-sensitive INS, the phagocytosis of IB was decreased, but chemotaxis was increased. These findings suggest a different pathogenesis between steroid sensitive and steroid non-sensitive INS. The dissociation between phagocytosis and chemotaxis may be explained by the alteration of the surface receptors of monocyte and by lymphokines.
D000293:Adolescent; D002634:Chemotaxis, Leukocyte; D002648:Child; D002675:Child, Preschool; D006801:Humans; D009000:Monocytes / Q000276:immunology / Q000502:physiology*; D009283:Naphthol AS D Esterase / Q000378:metabolism; D009404:Nephrotic Syndrome / Q000097:blood* / Q000276:immunology; D009580:Nitroblue Tetrazolium / Q000378:metabolism; D010587:Phagocytosis
D009580:Nitroblue Tetrazolium; D009283:Naphthol AS D Esterase