The effect of some new aminopyridines on mammalian non-myelinated nerve fibres.
We evaluated the action of 2,4-, 3,4-diaminopyridine and 3-[(dimethylamino)carbonyl]amino,4-aminopyridine (LF-14) on non-myelinated fibres of the guinea-pig vagus nerve. The amplitude and duration of the compound action potential were enhanced similarly by all of the aminopyridines. The propagation velocity of the compound action potential and electrogenic sodium pumping were not changed by the aminopyridines. The results show that 2,4-diAP and LF-14 affect non-myelinated nerve fibres of the guinea-pig in the same way as does 3,4-diAP; sodium pumping was not modified by the aminopyridines.
D015761:4-Aminopyridine / Q000031:analogs & derivatives*; D000200:Action Potentials / Q000187:drug effects; D000077770:Amifampridine; D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009412:Nerve Fibers / Q000187:drug effects*; D012964:Sodium / Q000378:metabolism; D014630:Vagus Nerve / Q000187:drug effects
D000631:Aminopyridines; C040030:LF 14; C026805:2,4-diaminopyridine; D012964:Sodium; D015761:4-Aminopyridine; D000077770:Amifampridine