[Thiol compounds in the combined therapy of prozerin poisonings].
The authors studied the protective action of dithiols (unithiol, dithiothreitol) and their combinations with atropine in proserine poisoning. With the use of the spatial-prospective plotting the antidote efficacy of dipyroxime, atropine, dithiothreitole, and their combinations was studied and compared. A new type of potentiation was discovered upon combined use of atropine, dipyroxime and dithiothreitol.
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D009388:Neostigmine / Q000506:poisoning*; D051381:Rats; D013438:Sulfhydryl Compounds / Q000627:therapeutic use*
D000931:Antidotes; D002800:Cholinesterase Inhibitors; D013438:Sulfhydryl Compounds; D009388:Neostigmine
Tiolovye soedineniia v kombinirovannoĭ terapii otravleniĭ prozerinom.