A quantitative determination of anticonvulsant-induced bone demineralization by an improved X-ray densitometry technique.
Quantitative studies of the influence of anticonvulsant drugs on bone mineral content of 88 epileptics were performed by a microcomputer-aided densitometer system. The results showed that the mineral content decreases significantly with the duration of the therapy. This decrease was found to be approximately 1.2% per year for a Diphenylhydantoin (DPH) monotherapy and 1.8% per year and 2.0% per year for a DPH plus Phenobarbital and DPH plus Carbamazepin combination therapy.
D015502:Absorptiometry, Photon / Q000379:methods*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000927:Anticonvulsants / Q000009:adverse effects*; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002220:Carbamazepine / Q000009:adverse effects; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D008838:Microcomputers; D008875:Middle Aged; D008903:Minerals / Q000032:analysis; D010018:Osteomalacia / Q000139:chemically induced* / Q000000981:diagnostic imaging; D010634:Phenobarbital / Q000009:adverse effects; D010672:Phenytoin / Q000009:adverse effects; D013997:Time Factors
D000927:Anticonvulsants; D008903:Minerals; D002220:Carbamazepine; D010672:Phenytoin; D010634:Phenobarbital