title: The bioavailability of two new preparations of spironolactone tablets.
abstract: Two new preparations of spironolactone tablets containing 25 and 100 mg of spironolactone have been characterized by their disintegration time, tablet spironolactone content, dissolution profile and bioavailability in comparison with two known spironolactone preparations as reference material. The preparations were found to possess almost identical characteristics, assuring a proper clinical use of the new tablet preparations. For spironolactone, a positive outcome of the in vitro dissolution test coincides with an excellent bioavailability.
mesh_terms: D000328:Adult; D001682:Biological Availability; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D012995:Solubility; D013148:Spironolactone / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism; D013607:Tablets
chemical_list: D013607:Tablets; D013148:Spironolactone