title: The role of naturally-acquired bacterial infection in influenza-related death in neonatal ferrets.
abstract: Concomitant, naturally-acquired bacterial infection was the cause of some deaths occurring in neonatal ferrets infected with the attenuated influenza virus A/Puerto Rico/8/34, these being prevented by antibiotic therapy. Bacterial infection played an insignificant role in the greater number of deaths following inoculation with the virulent clone 7a (of the recombinant influenza virus A/Puerto Rico/8/34-A/England/939/69/(H3N2]. As seen previously with clone 7a some ferret neonates infected with A/PR/8/34 died either from obstruction in the upper respiratory tract or from viral pneumonia, but with the latter virus, both types of lesion were probably attributable to the bacterial superinfection.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001424:Bacterial Infections / Q000150:complications / Q000401:mortality*; D005289:Ferrets; D007249:Inflammation; D009980:Influenza A virus / Q000302:isolation & purification; D008168:Lung / Q000382:microbiology / Q000473:pathology; D009976:Orthomyxoviridae Infections / Q000150:complications / Q000401:mortality* / Q000473:pathology; D014420:Turbinates / Q000382:microbiology / Q000473:pathology; D014774:Virulence
chemical_list: D000900:Anti-Bacterial Agents