[Acetylcholine potentiation of the serotonin-induced contractile reaction of the cat pyloric sphincter].
Isolated feline gastroduodenal junction was incubated in oxygenated Krebs solution maintained at 37 degrees C. Three types of spontaneous contractile activity were observed in the experiments. Acetylcholine and serotonin, 1.10(-11)-1.10(-5) mol/l, elicited contractile response of the pyloric sphincter consisting of tonic and rhythmic components. Acetylcholine, 1.10(-10)-1.10(-11) nmol/l, while being unable to induce contractile activity of the preparation, potentiated the contractile response of the pyloric sphincter elicited by serotonin.
D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D004357:Drug Synergism; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D011708:Pylorus / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology
D012701:Serotonin; D000109:Acetylcholine
Potentsirovanie atsetilkolinom sokratitel'noĭ reaktsii piloricheskogo sfinktera koshki, vyzvannoĭ serotoninom.