An in situ gastric pouch technique for direct measurement of the gastric absorption of drugs in the rat.
The preparation of an in situ gastric pouch technique that will allow a direct measurement of drug absorption is described. This technique has been developed in rats, but could be easily utilized in different laboratory animals. This technique has the major advantages of providing a direct measurement of the quantity of drug crossing the gastric mucosa into the bloodstream and enabling a direct comparison with results obtained using in situ intestinal loop preparations.
D000042:Absorption; D000818:Animals; D005753:Gastric Mucosa / Q000378:metabolism*; D008297:Male; D008722:Methods; D051381:Rats; D011919:Rats, Inbred Strains; D012459:Salicylates / Q000378:metabolism; D020156:Salicylic Acid; D013270:Stomach / Q000098:blood supply / Q000601:surgery
D012459:Salicylates; D020156:Salicylic Acid