Light microscopic autoradiographic localization of [3H]arginine-vasopressin binding sites in the rat brain and kidney.
Specific binding sites for arginine-vasopressin (VP) were demonstrated in various major target areas of VP in the rat brain and kidney by light microscopic autoradiography. In the kidney moderate and intense labelling was found in the cortical and medullar areas, respectively. Within the brain intense labelling was shown in the lateral septum, which lends further support to the hypothesis that VP acts as a neurotransmitter. In the hypophysis moderate and heavy labelling was found in the anterior and neural lobes, respectively, which is in agreement with the idea that VP influences hypophyseal functioning.
D000818:Animals; D001127:Arginine Vasopressin / Q000378:metabolism*; D001345:Autoradiography; D001665:Binding Sites; D001921:Brain / Q000378:metabolism*; D007668:Kidney / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution; D014316:Tritium
D014316:Tritium; D001127:Arginine Vasopressin