1 Alpha 2 alpha 3 alpha collagen is arthritogenic.
Native 1 alpha 2 alpha 3 alpha collagen (500 micrograms per rat) was both immunogenic and arthritogenic in Alderley Park rats (46% developed arthritis) but only immunogenic in Sprague-Dawley rats. Conversely, native type II collagen (500 micrograms per rat) was immunogenic and arthritogenic in both strains (64% arthritic in Alderley Park strain, 57% arthritic in Sprague-Dawley strain). The inflammatory polyarthritis induced by 1 alpha 2 alpha 3 alpha collagen was similar to that produced by native type II collagen in clinical appearance, time of onset, and histology. Antibodies raised to native bovine type II collagen cross-reacted with native 1 alpha 2 alpha 3 alpha collagen and vice versa. Thus the minor collagen component of cartilage, the 1 alpha 2 alpha 3 alpha collagen, as well as the major collagen component, type II collagen, are immunogenic and arthritogenic in the rat, with strain differences.
D000818:Animals; D001168:Arthritis / Q000209:etiology*; D001324:Autoantigens / Q000276:immunology; D003094:Collagen / Q000276:immunology*; D003429:Cross Reactions; D005260:Female; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D051381:Rats
D001324:Autoantigens; D007075:Immunoglobulin M; D003094:Collagen