[Hemosorption as a method of 5-fluorouracil elimination].
Procedures for removal of 5-fluorouracil from biological fluids by means of ADB-13 ty uncoated activated carbon were studied in vivo and in vitro. Dynamic stand trials showed a high sorptive capacity of carbon which appeared to depend on the rate and duration of perfusion. A 40 min passage through a carbon column at the perfusion rate of 100 ml/min was followed by a 584-fold decrease of the drug concentration. The pharmacodynamics of 5-fluorouracil was studied in dogs. The agent was injected intraperitoneally. The maximal hemosorptive effect was registered after the injection of lethal doses of 100 mg/kg. When therapeutic doses of 30 mg/kg were given hemosorption resulted in increased blood levels of the freely circulating drug.
D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005472:Fluorouracil / Q000008:administration & dosage / Q000097:blood*; D006464:Hemoperfusion; D007700:Kinetics
D005472:Fluorouracil
Gemosorbtsiia kak metod vyvedeniia 5-ftoruratsila iz organizma.