Pyridoxine deficiency and peripheral neuropathy associated with long-term phenelzine therapy.
A 51-year-old, nonalcoholic, nondiabetic woman with sensorimotor peripheral neuropathy and pyridoxine deficiency associated with long-term phenelzine therapy is described. Since phenelzine, like hydralazine and isoniazid, is a hydrazine capable of reducing pyridoxine levels in the rat, it is suggested that phenelzine, like hydralazine and isoniazid, may cause a pyridoxine-responsive peripheral neuropathy in humans.
D000230:Adenocarcinoma / Q000150:complications; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000150:complications; D008875:Middle Aged; D009422:Nervous System Diseases / Q000209:etiology; D010292:Paresthesia / Q000209:etiology; D010624:Phenelzine / Q000008:administration & dosage / Q000009:adverse effects*; D012677:Sensation; D026681:Vitamin B 6 Deficiency / Q000139:chemically induced*
D010624:Phenelzine