title: Lesions of the basal ganglia, thalamus, and deep white matter: differential effects on language functions.
abstract: Forty-five patients with unilateral demarcated vascular lesions in the basal ganglia, the thalamus and the deep white matter were investigated with an "aphasia battery." Patients with basal ganglia lesions performed worse than both other groups in tests of articulation, syntax, and lexical functions. The deficit of patients with basal ganglia lesions on all expressive language modalities was lateralized to the left hemisphere. Patients with left thalamic lesions showed impairments of speech fluency and in the Token Test. Patients with white matter lesions alone showed no effect of laterality in tests of language functions. The results are discussed on the basis of a recent theory of the participation of the deep nuclei in language processing.
mesh_terms: D000328:Adult; D000368:Aged; D001479:Basal Ganglia / Q000098:blood supply* / Q000473:pathology; D001931:Brain Mapping; D002561:Cerebrovascular Disorders / Q000150:complications*; D004292:Dominance, Cerebral / Q000502:physiology; D006801:Humans; D007806:Language Disorders / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged; D013788:Thalamus / Q000098:blood supply* / Q000473:pathology; D014057:Tomography, X-Ray Computed