title: [Functional relations between the adrenal cortex, thyroid gland and pineal body. I. Reactions of the adrenal cortex following interference with the thyroid regulatory cycle].
abstract: Histologic-cytological and morphometrical changes were investigated in the adrenal cortex of male Wistar-rats in experimental hypo- and hyperthyroid situation. Under hypothyroid metabolism's situation (methylthiouracil-application or thyroidectomy) a regressive transformation was found: It is a decrease of secretion of the fascicular zone. The glomerular zone was activated. After long-time application of high dosis of thyroxin, the histological findings show some criteria of an increasing function and also of a beginning exhaustion, too. It is evident, that the duration of the hyperthyroid situation is important. Thyroxin is an unspecific stressor. The long-time application of high thyroxin dosis induced a regressive transformation and atrophic changes in the adrenal cortex. The nuclei of the fascicular and the glomerular zone were diminuated significantly.
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects* / Q000502:physiology*; D000818:Animals; D008297:Male; D008779:Methylthiouracil / Q000494:pharmacology; D010870:Pineal Gland / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000502:physiology* / Q000601:surgery; D013965:Thyroidectomy; D013974:Thyroxine / Q000494:pharmacology
chemical_list: D013974:Thyroxine; D008779:Methylthiouracil
vernacular_title: Zur Frage funktioneller Beziehungen zwischen Nebennierenrinden, Schilddrüsen und Epiphysis cerebri. Teil I: Nebennierenrindenreaktionen nach Eingriffen am Schilddrüsenregelkreis.