Reduction of the hyaluronate concentration in rabbit aqueous humour by topical prednisolone.
Rabbits were treated topically with prednisolone for 5 or 10 days and aqueous humour removed immediately after treatment as well as 10 and 20 days later. The hyaluronate concentration was significantly lower in the treated eyes compared to control eyes. It returned to the normal level after withdrawal of the drug. Repeated sampling of aqueous humour at intervals of 10 days did not influence the hyaluronate concentration in the control group.
D000287:Administration, Topical; D000818:Animals; D001082:Aqueous Humor / Q000032:analysis*; D005260:Female; D006820:Hyaluronic Acid / Q000032:analysis*; D011239:Prednisolone / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors
D006820:Hyaluronic Acid; D011239:Prednisolone