Effects of dietary protein-tryptophan restriction upon 5-HT uptake by platelets and clinical symptoms in migraine-like headache.
Ten women with recurrent migraine-like headache, flush, urticaria and itching excoriations were put on a protein/tryptophan reduced diet. The 5-HT uptake kinetics in platelets, the frequency of headache attacks and skin symptoms were recorded. On customary food the 5-HT uptake kinetics were severely disturbed. On diet, the platelet 5-HT uptake was normalized and, in parallel, the migraine-like symptoms and skin manifestations were reduced. The parallel between the improvement in active 5-HT uptake by platelets and clinical symptoms during dietary protein/tryptophan restriction supports the idea that impairment of the 5-HT uptake in platelets is a contributory factor in the pathogenesis of migraine-like headache and other 5-HT related symptoms.
D000328:Adult; D001692:Biological Transport; D001792:Blood Platelets / Q000378:metabolism*; D004044:Dietary Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D008881:Migraine Disorders / Q000178:diet therapy / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism
D004044:Dietary Proteins; D012701:Serotonin; D014364:Tryptophan