title: [Pigmentation following sclerosis].
abstract: After discussing the psychological importance of the problem, the author stresses that the best treatment of pigmentations after sclerosis is prevention, based on experience and faultless technique (careful choice of sclerosants, local compression, evacuation of thrombi). The author then briefly reviews the pathophysiology of melanin dyschromias and their causes and presents the histological finding of a mixed origin for post-sclerosis pigmentations (melanin and iron). Various attempts at treatment are presented. The most effective form of treatment seems to be the percutaneous application of a mixture consisting of : -an iron chelator (desferoxamine), -an anti-inflammatory (alpha-chymotrypsin), -an anti-melanin agent (mequinol).
mesh_terms: D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D000840:Anisoles / Q000008:administration & dosage; D001205:Ascorbic Acid / Q000008:administration & dosage; D002918:Chymotrypsin / Q000008:administration & dosage; D003676:Deferoxamine / Q000008:administration & dosage; D006569:Hesperidin / Q000008:administration & dosage; D006801:Humans; D008543:Melanins / Q000037:antagonists & inhibitors; D010859:Pigmentation Disorders / Q000209:etiology* / Q000523:psychology / Q000628:therapy; D012597:Sclerosing Solutions / Q000009:adverse effects*
chemical_list: D000305:Adrenal Cortex Hormones; D000840:Anisoles; D008543:Melanins; D012597:Sclerosing Solutions; C009760:mequinol; D006569:Hesperidin; D002918:Chymotrypsin; D003676:Deferoxamine; D001205:Ascorbic Acid
vernacular_title: Les pigmentations après sclérose.