Recurrence risk of neural tube defects following a miscarriage.
Data from 280 sibships in three published series were used to see if the increased risk of neural tube defect (NTD) associated with having had a miscarriage in the immediately preceding pregnancy was also found in women with a previous affected pregnancy. A statistically significant relative risk of 4.0 (2-tail P = 0.0111, Fisher exact test) was found among such women, and this could not be accounted for by the effect of parity or of a history of miscarriage in general. The finding may be useful when counselling patients.
D000022:Abortion, Spontaneous / Q000453:epidemiology*; D004739:England; D005260:Female; D006801:Humans; D009436:Neural Tube Defects / Q000453:epidemiology* / Q000235:genetics; D009660:Northern Ireland; D010298:Parity; D011247:Pregnancy; D012306:Risk; D014852:Wales