Pyridoxine therapy in patients with renal calcium oxalate calculi.
In 12 patients with idiopathic calcium oxalate calculi pyridoxine was administered. Within six weeks mean daily oxalic acid excretion decreased from 480 +/- 122 mumol to 336 +/- 83 mumol. Glycolic acid excretion fell from 208 +/- 51 mumol to 153 +/- 26 mumol (normal range: oxalic acid 228-412 mumol/day, glycolic acid 130-290 mumol/day). The reduction of oxalic acid excretion seems to be beneficial in prevention of idiopathic calcium oxalate calculi.
D002129:Calcium Oxalate / Q000032:analysis; D006016:Glycolates / Q000652:urine; D006801:Humans; D007669:Kidney Calculi / Q000188:drug therapy* / Q000378:metabolism; D010070:Oxalates / Q000652:urine; D019815:Oxalic Acid; D011736:Pyridoxine / Q000627:therapeutic use*
D006016:Glycolates; D010070:Oxalates; C031149:glycolic acid; D002129:Calcium Oxalate; D019815:Oxalic Acid; D011736:Pyridoxine