A neighbour-exclusion intercalating model for poly(ADP-ribose) binding to DNA.
Molecular model building studies have shown that a poly-intercalative binding of poly(ADP-ribose) to DNA is sterically possible. In this model, poly(ADP-ribose) lies in the minor groove of DNA and adenine bases intercalate in a neighbour-exclusion mode. This binding mechanism could be used to recognize neighbour-exclusion intercalative sites on DNA.
D004247:DNA; D006860:Hydrogen Bonding; D046911:Macromolecular Substances; D008958:Models, Molecular; D008968:Molecular Conformation; D009702:Nucleoside Diphosphate Sugars; D011064:Poly Adenosine Diphosphate Ribose
D046911:Macromolecular Substances; D009702:Nucleoside Diphosphate Sugars; D011064:Poly Adenosine Diphosphate Ribose; D004247:DNA