title: Nifedipine in hypertensive emergencies of children.
abstract: We studied the acute antihypertensive effect of sublingually administered nifedipine in 21 patients with different clinical diagnoses. Nifedipine lowered systolic and diastolic BP from 181 +/- 18 and 136 +/- 21 mm Hg to 132 +/- 15 and 98 +/- 17 mm Hg, respectively, after 30 minutes, and produced a slight increase in heart rate. This is the first known study of administration of nifedipine for acute hypertension in children.
mesh_terms: D000293:Adolescent; D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D003131:Combined Modality Therapy; D004341:Drug Evaluation; D004630:Emergencies; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000628:therapy; D007676:Kidney Failure, Chronic / Q000150:complications; D008297:Male; D009543:Nifedipine / Q000627:therapeutic use*; D010530:Peritoneal Dialysis; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D009543:Nifedipine