Studies on the tissue disposition and fate of [14C]toxaphene in Japanese quail.
The disposition and the fate of a [14C]toxaphene preparation was studied in adult and juvenile female Japanese quail. The distribution of [14C]toxaphene in the body is dominated by high concentrations of radioactivity in the adipose tissue and the egg yolk, and, especially in juvenile birds, in the bone marrow. The [14C]toxaphene compounds present in the fat tend to be less polar than the parent [14C]toxaphene. More than half of the radioactive dose is excreted via the droppings, eggs, and preen gland within a few days, with biliary excretion playing a major role. The main part of the radioactivity in feces and urine consists of water soluble compounds, a part of which is indicated to be glucuronide and sulfate conjugates, but other metabolites are probably also present. A possible connection between the toxaphene residues in the bone and the known toxaphene induced osteomalacia in birds is discussed.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D001853:Bone Marrow / Q000378:metabolism; D002250:Carbon Radioisotopes; D002855:Chromatography, Thin Layer; D003370:Coturnix; D005260:Female; D007306:Insecticides / Q000378:metabolism*; D014018:Tissue Distribution; D014112:Toxaphene / Q000378:metabolism*
D002250:Carbon Radioisotopes; D007306:Insecticides; D014112:Toxaphene