Intravenous midazolam does not change lower oesophageal sphincter pressure.
The effect of intravenous midazolam 0.3 mg/kg on lower oesophageal sphincter (LOS) pressure was studied in 8 healthy volunteers. No effect on LOS pressure was noted. The importance of this finding in relation to the possible danger of gastro-oesophageal reflux and pulmonary aspiration of gastric acid content during induction of general anaesthesia is discussed.
D000328:Adult; D000777:Anesthetics; D001569:Benzodiazepines / Q000008:administration & dosage / Q000494:pharmacology*; D004943:Esophagogastric Junction / Q000187:drug effects / Q000502:physiology*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D008874:Midazolam; D009129:Muscle Tonus / Q000187:drug effects*
D000777:Anesthetics; D001569:Benzodiazepines; D008874:Midazolam