title: The role of the pericardium in interactions between the cardiac chambers.
abstract: Distension of one side of the heart involves both the atrium and the ventricle, and such atrioventricular enlargement encroaches more on pericardial volume than would ventricular distension alone. The influence of distension of the entire right side of the heart on the pressure-volume relationship of the entire left heart was studied in six postmortem canine hearts with intact pericardium. The pressure-volume relation of the left heart was determined when the right heart was empty and when it was filled with saline. The pressure-volume curve of the left heart became steeper when the volume of the right heart was increased. However, after subtracting pericardial pressure from the left heart pressure, the pressure-volume curves were unaffected by increased volume of the right heart. Selective distension of the entire right heart has a considerable effect on the filling characteristics of the left heart when the pericardium is intact, although this is less than that observed in experiments in which the more compliant atria have been excluded. This effect becomes negligible after subtracting pericardial pressure.
mesh_terms: D000818:Animals; D016275:Atrial Function; D001794:Blood Pressure; D002306:Cardiac Volume; D004285:Dogs; D006321:Heart / Q000502:physiology*; D010496:Pericardium / Q000502:physiology*; D016276:Ventricular Function