Cefoxitin vs. penicillin in the treatment of uncomplicated gonorrhea.
Four hundred six men and women with gonorrhea were randomly assigned to receive either 2 g of cefoxitin or 4.8 X 10(6) units of aqueous procaine penicillin G intramuscularly. All patients also received 1 g of probenecid orally. There was no statistically significant difference in the failure rate between patients treated with penicillin (4.3%) and those treated with cefoxitin (5.1%). Twelve (92%) of 13 homosexual men with gonococcal proctitis who received penicillin and 19 (95%) of 20 who received cefoxitin were cured. Adverse reactions were infrequent and mild in the cefoxitin-treated group. Three patients who received penicillin developed reactions consistent with procaine toxicity. It is concluded that cefoxitin is a safe and effective alternative to penicillin for treating uncomplicated anogenital gonorrhea in men and women.
D000328:Adult; D002440:Cefoxitin / Q000627:therapeutic use*; D005260:Female; D006069:Gonorrhea / Q000150:complications / Q000188:drug therapy*; D006716:Homosexuality; D006801:Humans; D008297:Male; D010402:Penicillin G Procaine / Q000627:therapeutic use*; D011349:Proctitis / Q000209:etiology; D011897:Random Allocation; D014526:Urethritis / Q000209:etiology
D010402:Penicillin G Procaine; D002440:Cefoxitin