Microbial transformations of natural antitumor agents XXII: Conversion of bouvardin to O-desmethylbouvardin and bouvardin catechol.
Bouvardin is a cyclic hexapeptide antitumor agent which undergoes two major microbial transformation reactions. Screening with 220 cultures revealed 17 different strains capable of producing O-desmethylbouvardin in good yield. O-Desmethylbouvardin was isolated and characterized from preparative scale incubations with Streptomyces rutgersensis NRRL B-1256. Four aspergilli and one streptomycete formed bouvardin catechol when O-desmethylbouvardin was used as substrate. Bouvardin catechol was isolated and characterized from a preparative scale incubation with Aspergillus ochraceous UI 398.
D000972:Antineoplastic Agents, Phytogenic / Q000378:metabolism*; D001230:Aspergillus / Q000378:metabolism; D001711:Biotransformation; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010456:Peptides, Cyclic / Q000378:metabolism*; D013302:Streptomyces / Q000378:metabolism
D000972:Antineoplastic Agents, Phytogenic; D010456:Peptides, Cyclic; C018234:bouvardin; C039587:O-desmethylbouvardin; C039588:bouvardin catechol