Catharanthus alkaloids, XXXVIII. Confirming structural evidence and antineoplastic activity of the bisindole alkaloids leurosine-N'b-oxide (pleurosine), roseadine and vindolicine from Catharanthus roseus.
Additional and confirming chemical and spectroscopic evidence for vindolicine (4), roseadine (5), and leurosine-N'b-oxide (6) is presented. Leurosine-N'b-oxide (6) was found to be exceptionally active in the B-16 melanoma test system in vivo. Roseadine (5), a new isolate of Catharanthus roseus, and 6 displayed significant activity in the P-388 lymphocytic leukemia test system in vivo. Preliminary spectral studies on the new alkaloid roseamine are also described.
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic; D055598:Chemical Phenomena; D002621:Chemistry; D002845:Chromatography; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010084:Oxidation-Reduction; D014748:Vinca Alkaloids / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D014748:Vinca Alkaloids; C039297:vindolicine; C039296:pleurosine; C039298:roseadine