Long-term sequelae of bronchiolitis induced by nitrogen dioxide in hamsters.
The long-term consequences of acute lung injury during critical growth periods of the lung were evaluated by inducing mild bronchiolitis with nitrogen dioxide (NO2) in 3-day-old (newborn) and 21-day-old (young) hamsters. Hamsters were exposed to 30 ppm NO2 for 7 days. Age-matched animals exposed to room air served as controls. Lung volumes, static deflationary pressure-volume curves, mean linear intercept, and internal surface area were measured when the animals reached 1 yr of age. Newborns exposed to NO2 showed an increased volume at 25 cm H2O pressure (V25) adjusted for body weight, a decreased transpulmonary pressure at 60% of V25, and an increased mean linear intercept when compared with control animals. The internal surface area was less than that in the control animals; the difference approached significance. In the young exposed group there were no differences for any measurements when compared with the control group. These data indicate that a mild injury imposed during the newborn period may result in physiologic and morphometric changes that simulate mild emphysema in the mature animal.
D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D001980:Bronchi / Q000503:physiopathology; D001996:Bronchopneumonia / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D006224:Cricetinae; D066298:In Vitro Techniques; D008168:Lung / Q000473:pathology / Q000503:physiopathology*; D008176:Lung Volume Measurements; D008297:Male; D009585:Nitrogen Dioxide; D009929:Organ Size; D011312:Pressure
D009585:Nitrogen Dioxide