The effect of opiate treatment on the postdecapitation reflex and monoamine metabolism in the rat spinal cord.
Post-decapitation seizures (PDR) are a spinal reflex which seems regulated by some monoaminergic neurons present in the spinal cord (S.C.). In order to better characterize the role of dopaminergic neurons in PDR, we studied the effect of treatment with opiates, which are known to increase dopamine (DA) and serotonin (5HT) metabolism in the brain, on the duration of PDR and on the metabolism of DA and 5HT in S.C. Morphine, given either IP or ICV, reduced the duration of PDR and increased DA metabolism. Both effects were more evident after systemic administration. [D-Ala2]Met5 enkephalin amide acted similarly to ICV administered morphine. Biochemical and behavioral effects were significantly correlated.
D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D012018:Reflex / Q000502:physiology*; D012701:Serotonin / Q000378:metabolism; D013116:Spinal Cord / Q000378:metabolism / Q000502:physiology*
D001679:Biogenic Amines; D012701:Serotonin; D004744:Enkephalin, Methionine; C022118:enkephalinamide-Met, Ala(2)-; D009020:Morphine; D004298:Dopamine