title: Release of adenosine in vivo from cat caudate nucleus.
abstract: A push-pull perfusion technique was used to study the release of endogenously synthesized [3H]-adenosine from caudate nucleus in the anaesthetized cat. The spontaneous release of [3H]adenosine newly synthesized from [3H]adenine reached a steady state level 40 min after the beginning of superfusion and continued for 4 h. Potassium and veratridine increased the release of newly synthetized [3H]-adenosine. The action of veratridine was completely blocked by tetrodotoxin. We conclude that spontaneous and evoked release of adenosine occurs in the cat striatum and might potentially affect central nervous function.
mesh_terms: D000241:Adenosine / Q000378:metabolism*; D000818:Animals; D002415:Cats; D002421:Caudate Nucleus / Q000378:metabolism*; D011188:Potassium / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology; D014701:Veratridine / Q000494:pharmacology
chemical_list: D013779:Tetrodotoxin; D014701:Veratridine; D000241:Adenosine; D011188:Potassium