title: The dissolution and bioavailability of rifampicin products in healthy subjects and tubercular patients.
abstract: Dissolution test of two rifampicin (RFP) products (DI and CB) was carried out by "Rotating Basket Method" on JP X, using a first and second fluid for disintegration test or a de-aerated water as dissolution medium. The dissolution ratios of the DI product in the second fluid and de-aerated water at 60 min are 72.0% and 95.0%, and the CB product ratios are 10.0% and 5.5% respectively. On their bioavailability parameters, the DI product showed higher C max and AUC value than CB, in both healthy subjects and tubercular patients, but did not show a statistically significant difference. Healthy subjects showed statistically significant high C max and AUC values as compared against tubercular patients, namely on C max of CB and DI products, and on AUC of CB and DI product.
mesh_terms: D000328:Adult; D001682:Biological Availability; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000378:metabolism*; D012995:Solubility; D014397:Tuberculosis, Pulmonary / Q000378:metabolism*
chemical_list: D012293:Rifampin