Pulmonary excretion of methanol in man.
An otherwise healthy methanol-poisoned male was treated with ethanol and forced diuresis. No acidosis or visual symptoms occurred. His blood ethanol concentrations varied between 10.7 and 30.0 mmol/l (0.49-1.38 g/l). His maximal blood methanol concentration was 14.4 mmol/l (0.45 g/l) and his plasma formate levels were within reference range (0.11-0.29 mmol/l). In a 24 h period where methanol metabolism was blocked by ethanol, the total body clearance and renal clearance of methanol were 11.3 and 5.7 ml/min, respectively. The difference, 5.6 ml/min, to a large extent reflects the pulmonary clearance of methanol thus being low in man.
D000328:Adult; D000431:Ethanol / Q000097:blood / Q000627:therapeutic use; D005561:Formates / Q000097:blood; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008297:Male; D000432:Methanol / Q000378:metabolism* / Q000506:poisoning
D005561:Formates; D000431:Ethanol; D000432:Methanol