[Thyroglobulin biosynthesis and the content of thyroglobulin polyribosomes of the thyroid gland cells in the normal state and in various types of thyroid pathology].
The content of polyribosomes in human thyroid cells was studied in health and different forms of thyroid pathology. In thyroid pathology, thyroglobulin (TG) polyribosome content in thyroid cells diminished in the following order: diffuse toxic goiter greater than mixed euthyroid goiter greater than nodular toxic goiter greater than Hashimoto's goiter and complete absence of TG synthesizing polyribosomes in thyroid cancer and congenital goiter cells. No correlation was revealed between polyribosome TG content and thyroid function. It is inferred that impairment of TG biosynthesis in thyroid diseases is related to the decreased content of polyribosome TG in thyroid cells.
D006801:Humans; D011132:Polyribosomes / Q000378:metabolism*; D013954:Thyroglobulin / Q000096:biosynthesis*; D013959:Thyroid Diseases / Q000473:pathology*; D013961:Thyroid Gland / Q000648:ultrastructure*
D013954:Thyroglobulin
Biosintez tireoglobulina i soderzhanie tireoglobulinovykh poliribosom v kletkakh shchitovidnoĭ zhelezy v norme i pri razlichnykh vidakh tireoidnoĭ patologii.