Attenuation of reversal deficits of mice with septal lesions by shifts in the motivational context.
Response perseveration following septal lesions, demonstrated on tasks that require change of a learned pattern of responding, depends in part on a relatively constant motivational context. The present experiment examined the effects of concurrent changes in the temperature of the water in a water-escape maze and the reversal of a spatial discrimination in mice that had received either septal lesions or control surgery. Control and experimental mice were trained on a spatial discrimination in either 17 or 34 degrees C water. Following acquisition, reversal training was conducted in the maze filled with the same-temperature water used during acquisition or water temperature as well as spatial reinforcement contingencies were reversed. When the water temperature remained constant across acquisition and reversal, the mice with septal lesions showed persistence during reversal training. Changing the water temperature concurrently with the institution of reversal training attenuated the perseverative deficits of mice with lesions, in contrast to the relative lack of effect in control animals. These results are discussed within the framework of the role that the septal region plays in attention.
D000818:Animals; D003216:Conditioning, Operant / Q000502:physiology*; D004193:Discrimination Learning / Q000502:physiology*; D004924:Escape Reaction / Q000502:physiology; D008297:Male; D011939:Mental Recall / Q000502:physiology; D051379:Mice; D009042:Motivation / Q000502:physiology*; D009949:Orientation / Q000502:physiology; D011930:Reaction Time / Q000502:physiology; D012193:Reversal Learning / Q000502:physiology*; D012688:Septum Pellucidum / Q000502:physiology*