The EOG in rheumatoid arthritis.
In untreated rheumatoid arthritis 20% of the patients has a EOG Lp/Dt ratio lower than the lower 5% limit calculated for normal patients. The EOG is more often disturbed in a long-standing chloroquin-induced retinopathy than in the acute phase of intoxication, the reason being progression from a maculopathy to a tapeto-retinal degeneration. The subnormal EOG in rheumatoid arthritis might be due to an auto-immune process against rhodopsin and uveal pigment. Withdrawal of synthetical antimalarial agents in cases suspected of an early drug-induced retinopathy based on EOG subnormality may enhance the underlying rheumatoid process thus causing a further decrease of the EOG. The EOG therefore is not a method of choice in detecting an early chloroquin-induced retinopathy.
D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001327:Autoimmune Diseases; D002738:Chloroquine / Q000009:adverse effects*; D004585:Electrooculography; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D012162:Retinal Degeneration / Q000139:chemically induced* / Q000175:diagnosis
D006886:Hydroxychloroquine; D002738:Chloroquine