Biopharmaceutical aspects of Depogen.
The absorption of Depogen was studied on an in vitro model and in various laboratory animals using stoichiometrically equivalent doses of drotaverin (No-Spa) calculated for drotaverin base for comparison. Blood levels of the drug were assessed by radiochemical and microchemical methods. Based on the results obtained and pharmacokinetic properties, the expectable optimal dosage and formulations for the possible field of indication were elaborated.
D000818:Animals; D001702:Biopharmaceutics; D004058:Diffusion; D004285:Dogs; D004338:Drug Combinations / Q000008:administration & dosage / Q000378:metabolism; D005260:Female; D008297:Male; D051379:Mice; D008954:Models, Biological; D010208:Papaverine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D051381:Rats; D013806:Theophylline / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism
D004338:Drug Combinations; C034813:drotaverine, acephyllinate drug combination; C005317:drotaverin; D013806:Theophylline; D010208:Papaverine