[Experimental study of the antihypertensive activity of unithiol, D-penicillamine and cysteine].
The thiol compounds, unithiol, D-penicillamine and cysteine administered per os, produce an antihypertensive effect in spontaneously hypertensive rats and in animals with experimental renovascular and DOCA-induced hypertension. The drugs reduce the pressor effect of angiotensin I and potentiate and prolong the depressor action of bradykinin in anesthetized normotensive rats. As for the activity unithiol and D-penicillamine are found to be superior to cysteine. This is in a good agreement with the drug inhibitory action in respect to dipeptidyl carboxypeptidase, an enzyme that plays the key role in the control of the activity of the renin-angiotensin and kallikrein-kinin systems of the body.
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D003545:Cysteine / Q000627:therapeutic use*; D004112:Dimercaprol / Q000031:analogs & derivatives*; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D006978:Hypertension, Renovascular / Q000188:drug therapy / Q000209:etiology; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010396:Penicillamine / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D014494:Unithiol / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D004112:Dimercaprol; D014494:Unithiol; D010396:Penicillamine; D003545:Cysteine
Eksperimental'noe izuchenie antigipertensivnoĭ aktivbnosti unitiola, D-penitsillamina i tsisteina.