Dynorphin-A-(1-8) is contained within vasopressin neurosecretory vesicles in rat pituitary.
Dynorphin-A-(1-8), an opioid peptide widely distributed in the rat central nervous system, is present in vasopressin-containing neurosecretory cells terminating in the neural lobe of the pituitary. Electron microscopic immunocytochemistry reveals that dynorphin-A-(1-8) is contained within the same neurosecretory vesicles as vasopressin and vasopressin-associated neurophysin in the neural lobe of the rat. The results indicate that dynorphin may be released in the pituitary concomitantly with vasopressin during the antidiuretic response.
D000818:Animals; D003594:Cytoplasmic Granules / Q000378:metabolism; D004399:Dynorphins; D004723:Endorphins / Q000378:metabolism*; D010446:Peptide Fragments / Q000378:metabolism*; D010904:Pituitary Gland, Posterior / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats; D013572:Synaptic Vesicles / Q000378:metabolism; D014667:Vasopressins / Q000378:metabolism*
D004723:Endorphins; D010446:Peptide Fragments; D014667:Vasopressins; D004399:Dynorphins; C026770:dynorphin (1-8)