The renin-aldosterone system in nephrogenic diabetes insipidus and the influence of hydrochlorothiazide and indomethacin.
Three generations of a family with nephrogenic diabetes insipidus were studied. Treatment of a male infant patient with hydrochlorothiazide normalized the serum sodium concentration and improved the clinical condition, but did not influence the polyuria. Although indomethacin alone was without long-term effect, combined therapy with hydrochlorothiazide and indomethacin regulated serum sodium better than hydrochlorothiazide alone. The renin-aldosterone system was not activated in healthy carriers or patients with nephrogenic diabetes insipidus neither in infancy during severe hypernatremic dehydration nor in adult patients.
D000293:Adolescent; D000328:Adult; D003919:Diabetes Insipidus / Q000097:blood* / Q000188:drug therapy / Q000235:genetics; D003928:Diabetic Nephropathies / Q000097:blood* / Q000188:drug therapy / Q000235:genetics; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D007213:Indomethacin / Q000627:therapeutic use; D007223:Infant; D008297:Male; D012084:Renin-Angiotensin System / Q000187:drug effects; D012964:Sodium / Q000097:blood; D014667:Vasopressins / Q000097:blood
D006852:Hydrochlorothiazide; D014667:Vasopressins; D012964:Sodium; D007213:Indomethacin