Fourier transform infrared spectra of cells treated with the drug adriamycin.
Fourier Transform Infrared Spectroscopy (FT-IR) is used to study the interaction of adriamycin molecule with DNA and/or cells. For the drug-DNA complexes, the data show that adriamycin interacts not only with the bases pair but also with the sugar-phosphate of DNA within intercalating process. In the case of treated tumor cells, spectra suggest that adriamycin could be interacting also with the proteins of the membrane. The obtained results show that FT-IR is a powerful technique in the study of biological system, say cells.
D002175:Candida; D002467:Cell Nucleus / Q000187:drug effects*; D002478:Cells, Cultured; D004317:Doxorubicin / Q000494:pharmacology*; D005583:Fourier Analysis; D006801:Humans; D013055:Spectrophotometry, Infrared / Q000295:instrumentation
D004317:Doxorubicin