title: Reduction in the frequency of N-methyl-N-nitrosourea-induced somatic mutations in Tradescantia by pretreatment with low doses of alkylating agents.
abstract: Treatment of Tradescantia cuttings with sub-mutagenic doses of N-methyl-N-nitrosourea (MNU), N-ethyl-N-nitrosourea and methyl methanesulphonate before challenging doses of MNU reduced the frequency of somatic mutations in stamen hairs as compared with the effect of challenging dose alone. The highest response was about a 50% reduction in the mutagenic effect of the challenge dose.
mesh_terms: D000477:Alkylating Agents / Q000494:pharmacology*; D004260:DNA Repair / Q000187:drug effects*; D008770:Methylnitrosourea / Q000037:antagonists & inhibitors*; D009154:Mutation / Q000187:drug effects*; D009607:Nitrosourea Compounds / Q000037:antagonists & inhibitors*; D010944:Plants
chemical_list: D000477:Alkylating Agents; D009607:Nitrosourea Compounds; D008770:Methylnitrosourea