Measurement of cerebral blood flow by washout of microwave induced heating.
A method is described for measurement of cerebral blood flow utilizing the washout of microwave delivered heating. Using a microwave source attenuated to achieve a brain temperature elevation of 0.5-0.75 degrees C after a 2 second exposure in the rat, cerebral blood flow was calculated from the temperature washout curve monitored by a small thermistor implanted in the brain. The results obtained with this method were comparable to those obtained using the [14C] butanol method. To our knowledge this represents the first description of a method to deliver a blood flow "indicator" atraumatically directly into brain tissue.
D000818:Animals; D001831:Body Temperature; D001921:Brain / Q000098:blood supply* / Q000000981:diagnostic imaging; D002250:Carbon Radioisotopes; D002560:Cerebrovascular Circulation; D006358:Hot Temperature; D008297:Male; D008722:Methods; D008872:Microwaves; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow
D002250:Carbon Radioisotopes