[Protective and therapeutic properties of the ubiquinones H6CoQ4 and CoQ9 in gamma irradiation].
Hexahydroubiquinone-4 (H6CoQ4) and ubiquinone-9 (CoQ9) in the form of solutions in vegetable oil administered to mice and rats subcutaneously and intragastrically produced a radioprotective effect comparable with that of cystamine. Under the accepted experimental conditions the compounds did not produce any therapeutic effect.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D005720:Gamma Rays; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014451:Ubiquinone / Q000031:analogs & derivatives* / Q000627:therapeutic use*
D011837:Radiation-Protective Agents; D014451:Ubiquinone; C001341:hexahydroubiquinone-4; C030571:ubiquinone 9
Zashchitnye i lechebnye svoĭstva ubikhinonov H6CoQ4 i CoQ9 pri gamma-obluchenii.