Indomethacin and the fetal renal nonfunction syndrome.
A pregnancy during which both beta-adrenergics and indomethacin were administered in order to stop preterm uterine contractions is reported. After 8 wk of therapy a Caesarean section was performed. The female neonate had all the characteristics of a Potter's facies, was anuric and died after 47 h of extra-uterine life. A possible relationship between this perinatal death and the prolonged intra-uterine exposure to indomethacin is discussed.
D000014:Abnormalities, Drug-Induced; D000328:Adult; D005145:Face; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects*; D007231:Infant, Newborn; D007668:Kidney / Q000002:abnormalities*; D008431:Maternal-Fetal Exchange; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D013577:Syndrome
D007213:Indomethacin