[Comparative study of the effect of verapamil and tubocurarine on acetylcholinesterase of skeletal muscle sarcolemma].
There are many similarities between verapamil and tubocurarine action on acetylcholinesterase of skeletal muscle sarcolemma: verapamil is equipotent with tubocurarine in its inhibitory effect; the kinetic analysis demonstrated the same (mixed) type of inhibition, the Hill coefficient is 0.7 and 0.6 for verapamil and tubocurarine suggested possible binding of verapamil and tubocurarine to the same sites.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D007700:Kinetics; D009132:Muscles / Q000201:enzymology*; D011817:Rabbits; D051381:Rats; D012508:Sarcolemma / Q000201:enzymology*; D014403:Tubocurarine / Q000633:toxicity*; D014700:Verapamil / Q000633:toxicity*
D014700:Verapamil; D000110:Acetylcholinesterase; D014403:Tubocurarine
Sravnitel'noe issledovanie deĭstviia verapamila i tubokurarina na atsetilkholinésterazy sarkolemmy skeletnykh myshts.