Gonadoblastoma in a patient with an isodicentric X chromosome.
Although gonadoblastoma is known to be associated with the presence of a Y chromosome, this case report of a 15-year-old patient with gonadal dysgenesis, gonadoblastoma, and an idic(Xq-) chromosome provides evidence for the occurrence of gonadoblastoma even in the absence of a Y chromosome. A review of previous cases reported to have gonadoblastoma in the absence of a Y chromosome revealed that the presence of some breast development was the common denominator among those patients. Therefore, a patient who presents with gonadal dysgenesis with some breast development, but lacks a Y chromosome may observe as close scrutiny as the patient with gonadal dysgenesis in the presence of a Y chromosome.
D000293:Adolescent; D002871:Chromosome Banding; D004407:Dysgerminoma / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D010051:Ovarian Neoplasms / Q000235:genetics*; D014424:Turner Syndrome / Q000150:complications*; D014960:X Chromosome