Safety and toxicity of oxamniquine in the treatment of Schistosoma mansoni infections, with particular reference to electroencephalographic abnormalities.
Thirty-seven patients infected with Schistosoma mansoni were treated with oxamniquine. All were cured. The only significant adverse reaction was the development of abnormal electroencephalographic (EEG) findings in 6 (17.6%) of 34 patients whose pretreatment EEG was normal. Management of patients, with particular reference to the EEG abnormalities, is discussed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004341:Drug Evaluation; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009600:Nitroquinolines / Q000009:adverse effects*; D010073:Oxamniquine / Q000009:adverse effects*; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000188:drug therapy*
D009600:Nitroquinolines; D010073:Oxamniquine