title: In vitro response of Blastocystis hominis to antiprotozoal drugs.
abstract: Ten antiprotozoal drugs were tested in vitro against four axenic strains of the intestinal parasite Blastocystis hominis. Inhibitory drugs in order of effectiveness were emetine, metronidazole, furazolidone, trimethoprim sulfamethoxazole, 5-chloro-8-hydroxy-7-iodo-quinoline (Entero-Vioform), and pentamidine. Moderately inhibitory were two quinolines other than iodochlorhydroxquin. These were chloroquine and 5,7-diiodo-8-hydroxy-quinoline (Floraquin). Diloxanide furoate was not inhibitory. Paromomycin and other antibiotics were not inhibitory. Entero-Vioform and metronidazole have been effective in human and higher primate diarrhea caused by B. hominis.
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D004640:Emetine / Q000494:pharmacology; D056890:Eukaryota / Q000187:drug effects*; D005663:Furans / Q000494:pharmacology; D005664:Furazolidone / Q000494:pharmacology; D008795:Metronidazole / Q000494:pharmacology; D010303:Paromomycin / Q000494:pharmacology; D010419:Pentamidine / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D013420:Sulfamethoxazole / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology
chemical_list: D000981:Antiprotozoal Agents; D005663:Furans; D011804:Quinolines; D008795:Metronidazole; D005664:Furazolidone; D010303:Paromomycin; D010419:Pentamidine; D014295:Trimethoprim; D013420:Sulfamethoxazole; D004640:Emetine; C004932:diloxanide furoate