title: Estimation of haplotype frequencies.
abstract: Maximum likelihood estimates of haplotype frequencies in multilocus systems are often zero and so may be genetically inacceptable. Estimation problems are discussed, and preferable estimates are derived.
mesh_terms: D000483:Alleles; D000818:Animals; D005787:Gene Frequency; D006238:Haploidy; D006801:Humans; D008433:Mathematics; D008957:Models, Genetic; D010641:Phenotype; D011336:Probability