Inhibition of gastric emptying by angiotensin in the rat and its antagonism by saralasin.
Angiotensin, administered by intraperitoneal route (0.1 - 100 micrograms/kg) significantly delayed gastric emptying in the conscious rat. This action, most probably connected with the spasmogenic effect on the gastroduodenal junction, was antagonized by saralasin (125 and 250 micrograms/kg intraperitoneally). Our data seem to suggest an action of the peptide on the stomach mediated through an interaction with specific receptors.
D000809:Angiotensins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D005746:Gastric Emptying / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012504:Saralasin / Q000494:pharmacology*
D000809:Angiotensins; D012504:Saralasin