Theophylline elimination in congestive heart failure.
The elimination of theophylline (clearance, half-life) was investigated in 50 patients with chronic congestive heart failure (grade III/IV) and in 20 controls. The cardiac diagnosis was based on clinical and hemodynamic parameters. Patients with congestion of the liver showed a significant reduction of the theophylline body clearance to 25.7 ml/kg/h +/- 12.1 vs 68.3 ml/kg/h +/- 14.8 in the control group, and a corresponding prolongation of the half-life to 5.7 h +/- 2.5 vs 3.1 h +/- 1.4 in the control group. The main pathogenetic factor is obviously the functioning hepatic tissue, reflected by the galactose elimination capacity (r = 0.666; P less than 0.01; theophylline clearance vs galactose elimination capacity).
D000328:Adult; D000368:Aged; D005260:Female; D006207:Half-Life; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D007700:Kinetics; D008111:Liver Function Tests; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D013806:Theophylline / Q000097:blood*
D013806:Theophylline