[Receptor binding of corticosterone in brain structures participating in regulation of the hypothalamo-hypophyseo-adrenal system].
Binding of corticosterone by the cytosol receptors after hydrocortisone administration was studied in different tissues of rats. A decrease in the specific binding of corticosterone occurred within 24 hrs in all the structures under study. In 3 days the decrease only persisted in the hypophysis and hypothalamus. The data suggest a connection between the long lasting decrease in the cytosol reception of corticosterone in the hypothalamus and hypophysis and the blockade of the hypothalamo-hypophyseal-adrenal system.
D015069:18-Hydroxycorticosterone / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D003345:Corticosterone / Q000031:analogs & derivatives* / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D010902:Pituitary Gland / Q000378:metabolism; D010913:Pituitary-Adrenal System / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D015069:18-Hydroxycorticosterone; D003345:Corticosterone
Retseptornoe sviazyvanie kortikosterona v strukturakh mozga, prinimaiushchikh uchastie v reguliatsii gipotalamo-gipofizarno-nadpochechnikovoĭ sistemy.