Intra-arterial chemotherapy of the liver with transient, repeated hypoxia.
Intra-arterial liver perfusion with transient repeated hypoxia via an indwelling double-lumen polyurethane catheter was undertaken in 25 of 33 patients with diffuse metastases involving 50%-70% of the liver, and whose primary cancer had previously been treated by local radical resections. Treatment continued over 3-12 months until disease progression and over 3-24 months until thrombosis. In 24 patients with colorectal carcinoma the 1-year survival rate (using the actuarial method) was 79% +/- 17%. The treatment morbidity was low. It is concluded that this form of treatment improves the quality of life and gives safe and effective palliation to the patients.
D000328:Adult; D000368:Aged; D002404:Catheterization; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use*; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000379:methods*; D008099:Liver / Q000098:blood supply*; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D011379:Prognosis
D005472:Fluorouracil