title: Effect of quercetin on two-stage carcinogenesis of the rat urinary bladder.
abstract: The initiating and promoting effects of quercetin on urinary bladder carcinogenesis in male F344 rats were examined histopathologically. No tumor or hyperplasia were observed in rats given 5.0% quercetin as initiator in the diet for 4 weeks followed by 0.001% N-butyl-N-(4-hydroxybutyl) nitrosamine (BHBN) for 29 weeks. Moreover, administration of 5.0% quercetin diet for 25 weeks after initiation with 0.01% BHBN for 4 weeks did not promote urinary bladder carcinogenesis. Furthermore, no lesions were detected in rats given 5.0% quercetin diet only. These results suggest that quercetin is not carcinogenic to rat urinary bladder.
mesh_terms: D000818:Animals; D001835:Body Weight; D002085:Butylhydroxybutylnitrosamine / Q000633:toxicity*; D003043:Cocarcinogenesis; D004032:Diet; D005419:Flavonoids / Q000494:pharmacology*; D006965:Hyperplasia; D008297:Male; D009602:Nitrosamines / Q000633:toxicity*; D010212:Papilloma / Q000139:chemically induced*; D011794:Quercetin / Q000494:pharmacology*; D051381:Rats; D011916:Rats, Inbred F344; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
chemical_list: D005419:Flavonoids; D009602:Nitrosamines; D002085:Butylhydroxybutylnitrosamine; D011794:Quercetin