[Locomotor activity and the nucleus accumbens].
Locomotor hyperactivity in rats was induced by microapplication of apomorphine (1 microgram/microliter) or picrotoxin (0.5 microgram/microliter) bilaterally into the n. accumbens and measured in an open field test. After systemic administration, the dopaminolytic drug haloperidol in doses between 0.06 and 0.25 mg/kg abolished both types of hypermotility. After an intraaccumbens injection of haloperidol (0.4 microgram/microliter, bilaterally) or carbachol (1.0 microgram/microliter, bilaterally), the apomorphine hypermotility was completely suppressed whereas the picrotoxin effect remained unchanged. Scopolamine which is known to induce hypermotility after systemic administration was, as methylatropine (1.0 mu/microliter bilaterally), too, without any locomotor effect after intraaccumbens injection. The locomotor inhibitory effect of haloperidol is discussed to be not restricted to its dopaminolytic action within the n. accumbens.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001286:Atropine Derivatives / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D007267:Injections; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology*; D009714:Nucleus Accumbens / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012601:Scopolamine / Q000494:pharmacology; D012686:Septal Nuclei / Q000502:physiology*
D001286:Atropine Derivatives; C006649:methylatropine; D002217:Carbachol; D012601:Scopolamine; D001058:Apomorphine
Lokomotorische Aktivität und Nucleus accumbens.