Comparison of efficacy of a single daily dose of 400 mg acebutolol and 100 mg atenolol in the treatment of arterial hypertension.
A double-blind, crossover comparison of once-daily acebutolol (400 mg) and once-daily atenolol (100 mg) was carried out in 33 patients with mild to moderate essential hypertension. After 8-weeks' treatment with acebutolol, the reduction (12%) in mean arterial pressure was, on average, slightly greater than that on atenolol (11%), but the difference was not significant. The mean 22-hour serum concentration of acebutolol plus its acetyl metabolite was 24% of the peak level, whereas that of atenolol was 12%. Routine laboratory monitoring showed no important changes. Acebutolol gave a statistically significant lesser reduction in pulse rate than atenolol, and a lesser incidence, approaching statistical significance (p less than 0.1), of side-effects.
D000070:Acebutolol / Q000008:administration & dosage / Q000627:therapeutic use*; D001262:Atenolol / Q000008:administration & dosage / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011674:Pulse / Q000187:drug effects; D013997:Time Factors
D001262:Atenolol; D000070:Acebutolol