Opiate antagonists, morphine and spatial memory in rats.
To assess the possible role of endogenous opioids on spatial memory, rats were administered morphine (1-15 mg/kg), naloxone (1-10 mg/kg), or naltrexone (0.1-10 mg/kg) at varying times after or prior to completing the first 4 choices in an 8 arm radial maze. None of these agents consistently affected retention, suggesting that endogenous opioid systems do not play a major role in modulating neural mechanisms that maintain accurate spatial memory.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000502:physiology; D008297:Male; D008568:Memory / Q000187:drug effects*; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D009271:Naltrexone / Q000494:pharmacology*; D051381:Rats; D012153:Retention, Psychology / Q000502:physiology
D004723:Endorphins; D009270:Naloxone; D009271:Naltrexone; D009020:Morphine