title: Failure of vasoactive intestinal peptide to stimulate aldosterone production.
abstract: The effect of vasoactive intestinal peptide (VIP) was studied on the aldosterone production of isolated rat adrenal glomerulosa cells. The peptide up to a concentration of 3 X 10(-7) mol/l failed to influence aldosterone production by isolated glomerulosa cells as well as to modify the response to a submaximal (2.5 X 10(-9) mol/l) concentration of angiotensin II. Therefore VIP, previously found in the adrenal zona glomerulosa by immunohistochemistry, is unlikely to exert a direct effect on the glomerulosa cells.
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism; D000450:Aldosterone / Q000096:biosynthesis*; D000804:Angiotensin II / Q000494:pharmacology / Q000502:physiology; D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014660:Vasoactive Intestinal Peptide / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D014664:Vasodilation / Q000187:drug effects
chemical_list: D000804:Angiotensin II; D014660:Vasoactive Intestinal Peptide; D000450:Aldosterone