Changes of the levels of antithrombin III in patients with cerebrovascular diseases.
Dynamic fluctuations of biological activities and antigen amounts of antithrombin III (AT-III) in acute cerebrovascular diseases were analyzed and evaluated. (1) AT-III levels assayed by both biological and immunological methods showed a gradual decrease with increasing age, and levels in patients with cerebral thrombosis were lower than those in patients with cerebral hemorrhage. (2) AT-III in cerebral thrombosis decreased slowly after administration of urokinase. After administration of aspirin (acetylsalicylic acid), however, AT-III levels increased presumably due to inhibition of coagulation activities. (3) Both biological activities and antigen amounts of AT-III increased after administration of an AT-III preparation, but the measured value, especially that of biological activity, was dissociated from the expected one, due to changes of the coagulation system after an operation.
D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000032:analysis*; D001241:Aspirin / Q000627:therapeutic use; D002545:Brain Ischemia / Q000097:blood; D002543:Cerebral Hemorrhage / Q000097:blood; D002561:Cerebrovascular Disorders / Q000097:blood*; D005260:Female; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D014568:Urokinase-Type Plasminogen Activator / Q000627:therapeutic use
D000990:Antithrombin III; D014568:Urokinase-Type Plasminogen Activator; D001241:Aspirin