Accumulation of vancomycin after intraventricular infusions.
A 50-year-old man with an infected intracerebral hematoma was treated with daily intraventricular infusions containing 10 mg of vancomycin (half the dose suggested by others). A vancomycin level in the ventricular CSF of 606 micrograms/ml after nine days of therapy indicates a potential for accumulation of this drug in patients with extensive brain damage.
D001927:Brain Diseases / Q000378:metabolism; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D008875:Middle Aged; D013203:Staphylococcal Infections / Q000188:drug therapy; D013997:Time Factors; D014640:Vancomycin / Q000008:administration & dosage* / Q000378:metabolism
D014640:Vancomycin