The effect of concentration and type of dietary protein hydrolysates on tumour growth in mice.
The effects of diets containing 12% (W/W) and 28% of casein or lactalbumin hydrolysate on the growth of implanted mammary adenocarcinoma H2712 in C3H-HeJ strain and fibrosarcoma 1038 in DBA-2J strain mice were compared. Our data indicate that amino acid intake in excess of the minimum requirement for normal growth of non-tumour-bearing mice enhances the growth of implanted fibrosarcoma and mammary carcinoma. The effect is not related to protein quality or amino acid distribution and appears to be solely dependent on the amino acid or nitrogen concentration in the diet.
D000818:Animals; D002364:Caseins / Q000494:pharmacology; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D004044:Dietary Proteins / Q000494:pharmacology*; D007768:Lactalbumin / Q000494:pharmacology; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000503:physiopathology
D002364:Caseins; D004044:Dietary Proteins; D007768:Lactalbumin