[Release delay of various antibiotics from resorbable tricalcium phosphate ceramic granules with soluble coating for local treatment of osteomyelitis. An animal experiment study].
The releasing kinetic of antibiotics from tricalcium phosphate beads was studied in animal experiments. The porous TCP-beads were filled with antibiotics and coated with biodegradable substances for delaying the release of the antibiotics. There were high tissue levels of antibiotics in the surrounding bone for many days. This method gains an increase in therapeutic safety in treatment of osteomyelitis. The coated TCP-antibiotic beads are used simultaneously as bone graft and for treatment of the bone infection. There is no need for further operation.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001842:Bone and Bones / Q000378:metabolism; D002130:Calcium Phosphates / Q000008:administration & dosage*; D003023:Cloxacillin / Q000031:analogs & derivatives*; D004285:Dogs; D004343:Drug Implants; D005436:Floxacillin / Q000378:metabolism / Q000627:therapeutic use*; D005578:Fosfomycin / Q000378:metabolism / Q000627:therapeutic use*; D010019:Osteomyelitis / Q000188:drug therapy*; D013977:Tibia
D000900:Anti-Bacterial Agents; D002130:Calcium Phosphates; D004343:Drug Implants; C485817:beta-tricalcium phosphate; D005578:Fosfomycin; D005436:Floxacillin; C018392:tricalcium phosphate; D003023:Cloxacillin
Die Freisetzungsverzögerung verschiedener Antibiotica aus resorbierbarem Tricalciumphosphat-Keramikgranulat durch die Verwendung löslicher Uberzüge zur lokalen Behandlung der Osteomyelitis. Eine tierexperimentelle Untersuchung.