Effects of acute pesticide poisoning on blood clotting in the rat.
Male Sprague-Dawley rats were treated with 1 ml of diazinon or malathion, 1750 ppm given orally by gavage. Clotting determinations included the prothrombin time, partial thromboplastin time, fibrinogen, and coagulation factors II, V, VII, and X, plus the hematocrit and platelet count. The results suggest that insecticides influence the clotting times of rats ingesting these insecticides even after as short a time span as 2 hr.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000032:analysis; D003976:Diazinon / Q000506:poisoning; D008294:Malathion / Q000506:poisoning; D008297:Male; D010575:Pesticides / Q000506:poisoning*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001779:Blood Coagulation Factors; D010575:Pesticides; D008294:Malathion; D003976:Diazinon