Antimicrobial activity and other in vitro properties of cefoperazone A, the principal metabolite of cefoperazone sodium.
Cefoperazone A, the principal metabolite of cefoperazone, was found to have an antimicrobial activity ranging from slightly below to 16-fold less than that of the parent drug. Like cefoperazone, the metabolite is bactericidal, penetrates well into bacterial cells, and has moderate beta-lactamase stability, some strains of members of the family Enterobacteriaceae produce an inoculum effect on the metabolite activity.
D001419:Bacteria / Q000187:drug effects*; D002438:Cefoperazone / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology; D004355:Drug Stability; D006801:Humans; D006868:Hydrolysis; D008826:Microbial Sensitivity Tests
C039259:cefoperazone A; D002438:Cefoperazone