[Analog of hippuran: (103 Ru)ruthenocenoyl-glycine derivative. Synthesis, organ distribution and clearance].
The analogue of hippuric acid, ruthenocenoyl-glycine was synthesized and labelled with the gamma-emitter 103Ru. As a by-product of the synthesis the labelled diamide from ruthenocene-dicarbonic acid and glycine was gained. With these ruthenocene derivatives the organ distributions in mice and rats were measured. All ruthenocene-glycine derivatives showed primary a high kidney accumulation followed by very rapid renal excretion. After application of the cytostatic PtCl2(NH3)2, causing toxic effects in the kidney of mice, the excretion of ruthenocenoyl-glycine is decreased. Biochemical data suggest the use of labelled ruthenocenoyl-glycine as a substitute for Iodo-labelled hippuran.
D000818:Animals; D005260:Female; D007553:Isotope Labeling; D007668:Kidney / Q000378:metabolism; D051379:Mice; D009942:Organometallic Compounds; D011868:Radioisotopes; D051381:Rats; D012428:Ruthenium; D014018:Tissue Distribution
D009942:Organometallic Compounds; D011868:Radioisotopes; D012428:Ruthenium; C039789:ruppuran
Analoga des Hippurans: [103Ru]Ruthenocenoyl-glycin-Derivate. Synthese, Organ-Verteilung und Clearance.