Strain differences in mice in the development of tolerance to the anti-pentylenetetrazole effects of diazepam.
The development of tolerance to the protective effects of diazepam (4 mg/kg) against seizures induced by pentylenetetrazole (PTZ) were studied in 3 strains of mice. Significant tolerance developed to protection against myoclonic jerks induced by PTZ (90-100 mg/kg) by day 5 in Tuck No. 1 and by day 10 in C3H/HE and CD-1 mice. Tolerance developed to protection against tonic-clonic convulsions by day 10 in Tuck No. 1 mice and by day 30 in the other strains. Diazepam remained protective against tonic-clonic convulsions (but not against myoclonus) induced by threshold doses of PTZ for 30 days in all 3 strains.
D000818:Animals; D003975:Diazepam / Q000494:pharmacology*; D004361:Drug Tolerance; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D009207:Myoclonus / Q000139:chemically induced*; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors*; D012640:Seizures / Q000139:chemically induced*; D013045:Species Specificity
D003975:Diazepam; D010433:Pentylenetetrazole