Adenosine activates a potassium conductance in guinea-pig atrial heart muscle.
Adenosine shortens the action potential and diminishes the force of contraction in guinea-pig left atria. These effects may be brought about by the activation of a potassium conductance. This assumption is supported by voltage clamp and 42K release experiments.
D000200:Action Potentials / Q000187:drug effects; D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D004553:Electric Conductivity; D006168:Guinea Pigs; D006321:Heart / Q000502:physiology*; D006325:Heart Atria; D009200:Myocardial Contraction / Q000187:drug effects; D011188:Potassium / Q000378:metabolism*
D000241:Adenosine; D011188:Potassium