Allergic contact dermatitis to topical corticosteroids: clobetasol propionate and clobetasone butyrate.
2 case reports are given of patients with positive patch test reactions to clobetasol propionate. One of the patients also reacted to clobetasone butyrate. 30 other steroids that were chemically very closely related to these two 21-chloro-9-alpha-fluoro-corticosteroids, were patch test negative. The literature on contact dermatitis reactions to corticosteroids is reviewed.
D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001623:Betamethasone / Q000031:analogs & derivatives*; D055598:Chemical Phenomena; D002621:Chemistry; D002990:Clobetasol / Q000009:adverse effects / Q000031:analogs & derivatives*; D003877:Dermatitis, Contact / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D010328:Patch Tests
D000305:Adrenal Cortex Hormones; D000893:Anti-Inflammatory Agents; C010893:clobetasone butyrate; D001623:Betamethasone; D002990:Clobetasol