Lead poisoning in monkeys during pregnancy and lactation.
Twenty-two female monkeys (Macaca irus) were given lead acetate by an intramuscular route during pregnancy and/or lactation. A high dose of lead (5 mg Pb2+/kg/day) can induce abortions and death in pregnant monkeys. At a lower dose (1 mg Pb2+/kg/day), the foetus can be exposed to lead via placenta and/or maternal milk. Studies using optical microscopy showed the typical renal lesions in mothers treated during pregnancy (five months) and an erythrodiapedesis in cerebral matter of the new-born at birth.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism / Q000502:physiology; D005260:Female; D005333:Fetus / Q000378:metabolism / Q000473:pathology; D007774:Lactation; D007854:Lead / Q000032:analysis / Q000378:metabolism*; D007855:Lead Poisoning / Q000378:metabolism* / Q000473:pathology; D008251:Macaca; D008895:Milk, Human / Q000032:analysis; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism* / Q000473:pathology; D014018:Tissue Distribution
D007854:Lead