[Idiopathic adult pulmonary hemosiderosis: a new etiopathogenetic hypothesis].
IPH is an uncommon disease affecting mainly children and adults and has usually a poor prognosis. The basic pathogenesis of the disorder is unknown; many theories have been advanced, but none is proved. A case of IPH in a 35 years old male presenting the atypical feature of a myeloperoxidase deficiency is reported. This unusual feature may be compatible with a generalized redox systems deficiency, which leads, via an impaired flow of iron into alveolar macrophages, to the pulmonary fibrosis.
D000328:Adult; D001856:Bone Marrow Examination; D004909:Erythrocyte Indices; D006486:Hemosiderosis / Q000209:etiology*; D006760:Hospitalization; D006801:Humans; D008171:Lung Diseases / Q000209:etiology*; D008297:Male
Emosiderosi polmonare idiopatica dell'adulto: una nuova ipotesi eziopatogenetica.