Comparison of the kinetics and utilisation of D(-)-and L(+)-sodium lactate in normal man.
After infusion of sodium D(-)L(+)-lactate in healthy man the clearance of the D(-)-isomer from blood was 70% of that of the L(+)-isomer. Utilisation of L(+)-lactate may have been inhibited by the presence of the D(-)-isomer. The changes in blood pyruvate concentration and ketone body ratio were compatible with mitochondrial oxidation of D(-)-lactate to pyruvate. After infusion of a D(-)L(+)-lactate racemic mixture, the renal excretion of the D(-)-isomer was much greater than that of the L(+)-isomer, although peak blood concentrations of the L(+) were higher than those of the D(-)-isomer. After infusion of sodium L(+)-lactate, the renal excretion of D(-)-lactate increased 7 times, although no D(-)-lactate could be detected in the blood or in the sodium L(+)-lactate infused.
D020155:3-Hydroxybutyric Acid; D000090:Acetoacetates / Q000097:blood; D000328:Adult; D000409:Alanine / Q000097:blood; D005260:Female; D006801:Humans; D006885:Hydroxybutyrates / Q000097:blood; D007700:Kinetics; D007773:Lactates / Q000097:blood / Q000378:metabolism* / Q000652:urine; D019344:Lactic Acid; D008297:Male; D011773:Pyruvates / Q000097:blood; D019289:Pyruvic Acid; D013237:Stereoisomerism
D000090:Acetoacetates; D006885:Hydroxybutyrates; D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; C016635:acetoacetic acid; D019289:Pyruvic Acid; D000409:Alanine; D020155:3-Hydroxybutyric Acid