Residual radiation damage in the mouse foot after exposure to argon ions and retreatment with X rays.
The results of radiation treatment as visible residual damage are reported for acute skin reaction and foot deformity in mice exposed to argon ions. Two groups of 40 mice each were exposed to argon ions at the plateau and peak center of a 10-cm-wide Bragg peak to a fixed dose of 1200 and 1300 rad, respectively. A third group of 40 mice was exposed to 1750 rad of 250-kVp X rays while the fourth group was kept as controls. The acute skin reactions were scored for 60 days and foot deformity at 8 months after exposure. These mice were reexposed 8 months after the first exposure to graded doses of X rays ranging from 1200 to 2500 rad. Acute skin reactions were scored again for 60 days and foot deformity 8 months after the second exposure to graded doses of X rays. The results showed that no significant visible residual damage of the first treatment of either argon ions or X rays was observed after a second irradiation with X rays for acute skin reaction. For the end point deformity, however, residual damage of the first treatment was observed. The residual damage for foot deformity for argon ions does not seem to be higher than for X rays when the doses of first treatment with argon ions and X rays were matched to produce nearly uniform effect. The results also suggest a threshold dose to show the residual damage of the first treatment.
D000208:Acute Disease; D000818:Animals; D001128:Argon / Q000009:adverse effects*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005528:Foot / Q000528:radiation effects*; D005531:Foot Deformities, Acquired / Q000209:etiology; D007477:Ions; D051379:Mice; D008815:Mice, Inbred Strains; D011855:Radiodermatitis / Q000209:etiology*; D011868:Radioisotopes / Q000009:adverse effects*; D013997:Time Factors
D007477:Ions; D011868:Radioisotopes; D001128:Argon