A testis antigen related to the brain D2 adhesion protein.
The localization of an antigen immunochemically crossreactive with the rat brain interneuronal adhesion molecule, D2-protein, has in testis been demonstrated by immunoelectrophoresis and immunocytochemistry. This D2-like antigen is localized to spermatids and residual bodies in testis, but it is absent both from spermatogonia and mature spermatozoa and from Sertoli cells. By immunoperoxidase electronmicroscopy D2-like antigen was observed in the head region posterior to the acrosomal membrane of late spermatids. In the nervous system D2-protein is involved in interneuronal adhesion. It is suggested that D2-like antigen in testis may be involved in a similar adhesion between late spermatids and Sertoli cells during spermiation.
D000818:Animals; D000941:Antigens / Q000276:immunology*; D001921:Brain / Q000276:immunology*; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules; D003429:Cross Reactions; D008297:Male; D009419:Nerve Tissue Proteins / Q000276:immunology*; D051381:Rats; D012671:Seminiferous Tubules / Q000276:immunology; D013737:Testis / Q000276:immunology*
D000941:Antigens; D015815:Cell Adhesion Molecules; D009419:Nerve Tissue Proteins