Effect of the peptide PHI-27 on prolactin release in vitro.
The present study demonstrates that PHI, a peptide belonging to the glucagon-secretin group and thus structurally similar to VIP, can release prolactin from dispersed rat anterior pituitary cells and also causes release of prolactin from hemipituitaries. PHI-like immunoreactivity has previously been demonstrated in a hypothalamic system with nerve endings in the median eminence, and, taken together, these findings suggest that PHI may represent a physiologic prolactin-releasing factor.
D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D010451:Peptide PHI; D010455:Peptides / Q000494:pharmacology*; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology
C039892:PHI peptide, Gln(24)-; D010451:Peptide PHI; D010455:Peptides; D014660:Vasoactive Intestinal Peptide; D011388:Prolactin