Effect of vaccination schedule and dialysis on hepatitis B vaccination response in uraemic patients.
Antibody response to vaccination with hepatitis B vaccine (HB-Vax) was evaluated in 43 staff, 81 dialysis patients and 12 non-dialysed uraemic patients. We confirmed less frequent seroconversion and lower concentration of antibody to hepatitis B surface antigen (anti-HBs) in dialysis patients despite a higher dose (40 micrograms vaccine). However, more frequent vaccination (5 times vs 3) increased anti-HBs concentration to almost normal. Concomitant administration of hepatitis B immunoglobulin (HBIG) and hepatitis B vaccine (passive/active) did not interfere with vaccination success. Antibody response was equally poor in dialysed non-dialysed uraemic patients.
D000328:Adult; D000914:Antibodies, Viral / Q000096:biosynthesis; D005260:Female; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013997:Time Factors; D014511:Uremia / Q000276:immunology* / Q000628:therapy; D014765:Viral Vaccines / Q000008:administration & dosage*
D000914:Antibodies, Viral; D014765:Viral Vaccines