Gossypol. Synthesis and in vitro spermicidal activity of isomeric hemigossypol derivatives.
Three isomeric hemigossypol derivatives (3,4,5) have been synthesized. Two of these derivatives (3,4) and one synthetic intermediate (7) have been shown to have activity comparable to gossypol (1) in a sperm motility assay.
D000818:Animals; D006224:Cricetinae; D006072:Gossypol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D007536:Isomerism; D008297:Male; D013081:Sperm Motility / Q000187:drug effects*
D006072:Gossypol