[Human stomach cancer bearing similarity to experimentally induced stomach cancer in rats].
A periodical and histological study on the histogenesis of experimental stomach carcinoma induced by N-methyl-N'-nitro-N-nitrosoguanidine in rats suggested that cancer progression occurred from the submucosal focus under the condition of existing adenomatous hyperplasia. This carcinoma manifested particular atypia, combined hyperplasia of the smooth muscle, indistinct borderline from the surrounding normal mucosa. These were considered to be specific histological findings in experimental carcinoma. In 3 of 273 gastrectomized patients with gastric carcinoma the same histological findings were obtained as in experimental gastric carcinoma; 35 patients had submucosal heterotopic glands similar to the experimentally induced rat foci or adenomatous hyperplasias seen in the experimental carcinoma. These results suggest the same histogenesis for human stomach cancer and the experimental carcinoma.
D000368:Aged; D000818:Animals; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008769:Methylnitronitrosoguanidine; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D051381:Rats; D011919:Rats, Inbred Strains; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000473:pathology*
D008769:Methylnitronitrosoguanidine