Experimental study of pulsatile and steady flow through a smooth tube and an atherosclerotic coronary artery casting of man.
In vitro investigation of pulsatile and steady flows through a smooth, straight circular tube and a diseased human coronary artery cast was conducted with sugar-water solutions simulating the viscosity of blood. Time averaged pressure drops for pulsatile flows measured in the circular tube over a Reynolds number ranging from 50 to 1,000 were found to be identical to those for steady flows in the same tube, both of which were in excellent agreement with the Poiseuille flow prediction. For the polyurethane case (# 124) made from a human main coronary with significant but 'non obstructive' diffuse atherosclerotic disease, pressure drops for steady flows were found to be greater than Poiseuille flow predictions by a factor of 3-8 in the physiological Reynolds number range from about 100 to 400. Pulsatile flows in the same artery cast resulted in additional 30% increases in time averaged pressure drops, and thus flow resistance, compared to the steady flow data. Steady and pulsatile flow data measured in a straight, axisymmetric model of cast # 124 showed considerably smaller increases in flow resistance than those observed in # 124 casting.
D001161:Arteriosclerosis / Q000503:physiopathology; D001783:Blood Flow Velocity; D003327:Coronary Disease / Q000503:physiopathology*; D006801:Humans; D066298:In Vitro Techniques; D008953:Models, Anatomic; D012212:Rheology; D014655:Vascular Resistance