title: Dose response of topical pilocarpine-epinephrine combinations in normotensive and glaucomatous Beagles.
abstract: Dose responses to single-dose loadings with a placebo (0.50% methylcellulose) and 1%, 2%, 3%, 4%, and 6% pilocarpine combined with 1% epinephrine were determined in normotensive and glaucomatous Beagle dogs. All combinations of pilocarpine and 1% epinephrine significantly (P less than 0.007) reduced pupil size and intraocular pressure in the normotensive and glaucomatous-treated eyes at most measurement times, as compared with base-line (predrug) values, untreated fellow eyes, and placebo-treated eyes. There were no significant (P less than 0.11 or greater) contralateral effects on pupil size and intraocular pressure by unilateral pilocarpine-epinephrine instillations as compared with base-line values or placebo-treated eyes.
mesh_terms: D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004837:Epinephrine / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D010862:Pilocarpine / Q000008:administration & dosage* / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects
chemical_list: D004338:Drug Combinations; D010862:Pilocarpine; D004837:Epinephrine