Tubocurarine has no clear effect on the metabolism of exogenous arachidonic acid in hamster isolated lungs.
The effect of tubocurarine on the metabolism of exogenous 14C-arachidonic acid (14C-AA) was investigated in isolated perfused hamster lungs. When 40 nmol of 14C-AA was infused in two minutes into the pulmonary circulation the perfusion pressure increased and 14C-AA metabolized to prostaglandins, thromboxane and lipoxygenase metabolites which were analysed from the nonrecirculating perfusion effluent. When tubocurarine (4 or 40 micrograms/ml) was infused into the pulmonary circulation the increase in the perfusion pressure was not changed and the amounts of arachidonate metabolites were not changed dose dependently. At 4 micrograms/ml tubocurarine slightly decreased the amount of some prostaglandins (eg. PGE2) but with the higher concentration of 40 micrograms/ml no significant changes were detected. The present study indicates that tubocurarine has no clear dose dependent effect on the metabolism of exogenous arachidonic acid in hamster lungs.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism*; D002250:Carbon Radioisotopes; D006224:Cricetinae; D005260:Female; D066298:In Vitro Techniques; D008168:Lung / Q000378:metabolism*; D008647:Mesocricetus; D011453:Prostaglandins / Q000096:biosynthesis; D014403:Tubocurarine / Q000494:pharmacology*
D001095:Arachidonic Acids; D002250:Carbon Radioisotopes; D011453:Prostaglandins; D014403:Tubocurarine