[Therapeutic activity of the combined use of an interferon inducer and vaccine in experimental rabies].
Experiments in mice inoculated intramuscularly with a large dose of virulent street rabies virus demonstrated effectiveness of combined treatment with an interferon inducer (double-strand RNA) and vaccine. The treatment was started 24 hours after inoculation. The degree of protection of the animals treated by the combined method depended on the site of ds-RNA inoculation: intracerebral inoculation produced 58% protection (P less than 0.001), intravenous 35% (P less than 0,01), and intramuscular 21% (P less than 0.05). Vaccine alone was ineffective. Interferon inducer alone produced no significant protection which was due to the large infective dose of the virus.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D005260:Female; D007369:Interferon Inducers / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D012330:RNA, Double-Stranded / Q000008:administration & dosage / Q000627:therapeutic use*; D011818:Rabies / Q000517:prevention & control*; D011819:Rabies Vaccines / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D011819:Rabies Vaccines
Lechebnaia aktivnost' kombinirovannogo primeneniia induktora interferona i vaktsiny pri éksperimental'nom beshenstve.