[Comparative study of the effectiveness of various doses of estrogens after their "central" and "peripheral" administration].
Experiments on male rats were made to study the effects of synestrol and diethylstilbestrol on the sexual organs. The drugs were administered subcutaneously and into the CSF. Diethylstilbestrol propionate produced the most potent inhibitory action on proliferative processes in the prostate. This inhibition was found to be the most demonstrable when the drug was administered into the CSF. During endo-CSF administration the dose of the hormone could be considerably decreased, with the inhibitory action on the target organs being unchanged and side effects on the animal body being minimal.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004028:Dienestrol / Q000008:administration & dosage*; D004054:Diethylstilbestrol / Q000008:administration & dosage / Q000031:analogs & derivatives*; D045166:Estradiol Congeners / Q000008:administration & dosage*; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010636:Phenols / Q000008:administration & dosage*; D011467:Prostate / Q000187:drug effects*; D051381:Rats; D013737:Testis / Q000187:drug effects*
D045166:Estradiol Congeners; D010636:Phenols; D004054:Diethylstilbestrol; D004028:Dienestrol; C000937:diethylstilbestrol dipropionate
Sravnitel'noe issledovanie éffektivnosti razlichnykh doz éstrogenov pri ikh "tsentral'nom" i"perifericheskom" vvedenii.