Adult age destruction versus neonatal age destruction of the serotonin system: two models to investigate the survival of serotonin neurons transplanted in adult rats.
Mesencephalic raphe nuclei were transplanted via the cisterna magna in the IVth ventricle of adult rats having received either a neonatal or an adult age destruction of the serotonin system. In neonatally treated rats both serotonin (5-HT) and glial fibrillary acidic protein (GFA) immunocytochemistry showed an absence of survival of 5-HT neurons in the transplants. However, many 5-HT immunoreactive cell bodies and processes were detected in 10-month-old transplants in adult treated animals. These results suggest that recognition processes between the target tissue and the implant may be a prerequisite for the survival of grafted neurons.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001933:Brain Stem / Q000637:transplantation*; D005904:Glial Fibrillary Acidic Protein; D007381:Intermediate Filament Proteins / Q000378:metabolism; D008636:Mesencephalon / Q000378:metabolism / Q000637:transplantation*; D008959:Models, Neurological; D011903:Raphe Nuclei / Q000378:metabolism / Q000637:transplantation*; D051381:Rats; D012701:Serotonin / Q000378:metabolism / Q000502:physiology*
D005904:Glial Fibrillary Acidic Protein; D007381:Intermediate Filament Proteins; D012701:Serotonin