[Pulmonary hemorrhages in newborn infants with inborn errors of the 1st 2 phases of the urea cycle].
Two critically ill, male newborns developed pulmonary bleeding and died after four respectively three days. In both infants an inborn error in the urea cycle (carbamylphosphatsynthetase-deficiency and ornithintranscarbamylase-deficiency respectively) was demonstrable. It is suggested that hyperammonemia could be the reason for pulmonary bleeding. Plasma ammonia levels should be determined in newborns with pulmonary bleeding, especially in those with normal weight and good health at birth.
D000592:Amino Acid Metabolism, Inborn Errors / Q000150:complications*; D000641:Ammonia / Q000097:blood; D002222:Carbamoyl-Phosphate Synthase (Ammonia) / Q000172:deficiency; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D014508:Urea / Q000378:metabolism*
D000641:Ammonia; D014508:Urea; D002222:Carbamoyl-Phosphate Synthase (Ammonia)
Lungenblutung bei Neugeborenen mit angeborenen Störungen der ersten zwei Schritte im Harnstoffzyklus.