[Effect of adrenalectomy and hydrocortisone on insulin receptors of rat fat cell plasma membranes].
Specific insulin binding with insulin receptors of fatty acid plasma membranes is established to be intensified 10 days after adrenalectomy in rats due to an increase in the receptor number. Hydrocortisone administered for 10 days in a dose of 1 mg per 100 g of body mass to adrenalectomized rats for substitution therapy and to intact ones for 14 days in a dose of 5 mg per 100 g of body mass to induce hypercorticism inhibits the expression of insulin receptors of fatty plasma membranes because of their number and affinity for the hormone. The data obtained confirm information on an inhibitory effect of glucocorticoids on the expression of insulin receptors.
D000273:Adipose Tissue / Q000187:drug effects / Q000378:metabolism*; D000315:Adrenalectomy; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011972:Receptor, Insulin / Q000378:metabolism*
D011972:Receptor, Insulin; D006854:Hydrocortisone
Vliianie adrenaléktomii i gidrokortizona na insulinovye retseptory plazmaticheskikh membran zhirovykh kletok krysy.