De novo translocation heterozygote with three reciprocal translocations.
An extremely rare case of a child with three balanced reciprocal translocations involving six different autosomes is described. These abnormalities have apparently arisen de novo and seem to have only relatively minor phenotypic effects. The meiotic possibilities are discussed and cytogenetic markers suggest that the damage may have occurred in a paternal gamete.
D002648:Child; D002871:Chromosome Banding; D002900:Chromosomes, Human, 1-3; D002901:Chromosomes, Human, 13-15; D002902:Chromosomes, Human, 16-18; D002905:Chromosomes, Human, 4-5; D002906:Chromosomes, Human, 6-12 and X; D006130:Growth Disorders / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D008297:Male; D008540:Meiosis; D014178:Translocation, Genetic