Prostaglandin B1 can modify the pressor responses to sympathetic nerve stimulation.
PGB1, a metabolite of PGA1, has the ability to enhance peripheral vascular resistance and elevate blood pressure in animals whose vascular tone is low. The effect is not central in origin and apparently is not the result of changes in cholinergic or alpha-adrenoceptor sensitivity or changes in vascular smooth muscle susceptibility per se.
D000109:Acetylcholine / Q000494:pharmacology; D000315:Adrenalectomy; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004558:Electric Stimulation; D008297:Male; D011453:Prostaglandins / Q000494:pharmacology*; D011456:Prostaglandins B / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013564:Sympathetic Nervous System / Q000187:drug effects*; D014630:Vagus Nerve / Q000502:physiology
D011453:Prostaglandins; D011456:Prostaglandins B; C034467:prostaglandin B1; D000109:Acetylcholine