title: First experimental and clinical results of isolated liver perfusion with cytotoxics in metastases from colorectal primary.
abstract: In two patients suffering from numerous liver metastases in both lobes from colorectal primary isolated liverperfusion with 5-fluorouracil was performed. By means of a special cannulation system the hepatic artery and the portal vein were arterialized. The patients recovered rapidly after the operation. Sonographic measurements, CAT scans, pulse cytophotometry, and second-look operations with histological examinations of metastatic tissue verified extensive tumor regression. No complications occurred within 6 months after the perfusion treatment.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002404:Catheterization / Q000295:instrumentation; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000295:instrumentation*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D003606:Dacarbazine / Q000627:therapeutic use; D004285:Dogs; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008727:Methotrexate / Q000627:therapeutic use; D012004:Rectal Neoplasms / Q000188:drug therapy*
chemical_list: D000970:Antineoplastic Agents; D003606:Dacarbazine; D005472:Fluorouracil; D008727:Methotrexate