Osteoclastoma. A review of the condition and a report of 5 cases.
The presence of giant cells in a tumour does not justify the diagnosis of osteoclastoma. Although some may dispute the existence of the osteoclastoma, its radiological and microscopic features are sufficiently typical to justify its classification as a separate tumour. It is believed that the tumour arises from proliferating capillary buds from cells which have the potential of becoming collagenoblasts, osteoblasts, chondroblasts or histiocytes. It is suggested that the giant cells are made up of merged matrix cells. Since it is believed that the true osteoclastoma is always malignant (although it is late to metastasize) and since it has a high potential for recurrence, initial treatment should be radical and should consist of block excision or amputation.
D000293:Adolescent; D000328:Adult; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D005870:Giant Cell Tumors / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged