title: Development of the subcommissural organ in the albino mouse (a Golgi study).
abstract: The Subcommissural organ (SCO) of the albino mouse has been examined using the Golgi method and stained paraffin sections from embryonic age E 11 up to adulthood. The SCO cells can first be distinguished from adjacent structures at E 14, but are not fully differentiated until the age of 6 postnatal weeks. The first signs of cytological maturation occur during early postnatal life with a progressive invagination of the nuclear membrane and a transformation of the peripheral processes, which involute or are lost in adulthood. The hypendyma appears at the age of three weeks. A third type of cell is described which is interpreted as a transitional element between ependymal and hypendymal SCO cells. In general, the mouse SCO is characterized by an early appearance in prenatal life and a late acquisition of the final differentiated state.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002552:Cerebral Ventricles / Q000166:cytology; D004805:Ependyma / Q000166:cytology; D005260:Female; D005865:Gestational Age; D008636:Mesencephalon / Q000166:cytology; D051379:Mice; D009186:Myelin Sheath / Q000648:ultrastructure; D009474:Neurons / Q000166:cytology; D009490:Neurosecretory Systems / Q000166:cytology*; D011247:Pregnancy; D013351:Subcommissural Organ / Q000166:cytology*