Development of adenocarcinomas after transplantation of rat glandular stomachs treated in vitro with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG).
Glandular stomachs of fetal and newborn Wistar rats were transplanted s.c. after treatment in vitro with N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) at concentrations of 10, 5 and 1 microgram/ml for 2 h. Eleven adenocarcinomas developed from 118 MNNG-treated transplants, whereas no adenocarcinomas developed from 28 untreated transplants. The incidence of adenocarcinomas in fetal glandular stomach (9/46) was significantly different (p less than 0.01) from that in glandular stomach of newborn rats (2/67). Various types of mesenchymal tumors also developed from untreated (9/28) and MNNG-treated (20/118) transplants.
D000230:Adenocarcinoma / Q000139:chemically induced* / Q000473:pathology; D000818:Animals; D004622:Embryo, Mammalian; D008297:Male; D008769:Methylnitronitrosoguanidine; D009368:Neoplasm Transplantation; D009924:Organ Culture Techniques; D051381:Rats; D011919:Rats, Inbred Strains; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology
D008769:Methylnitronitrosoguanidine