title: [Thin-layer chromatographic determination of pyrantel in cow's milk and blood serum after oral administration of Banminth].
abstract: After oral administration of the anthelmintic Banminth to cows the effective agent pyrantel appeared unchanged in blood serum and milk. After a therapeutic dose of 12,1 mg pyrantel tartrate/kg body weight, a maximum level of 8-9 micrograms/l could be found in milk 0-24 h after the application; the highest concentration of 22 micrograms/l in blood serum appeared after 10 h and the half-life time of elimination was ca. 15 h. Pyrantel determination in milk and blood serum was performed by quantitative thin layer chromatography. Positive results could be verified by HPLC.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002417:Cattle; D002855:Chromatography, Thin Layer; D005260:Female; D005506:Food Contamination / Q000032:analysis; D006207:Half-Life; D008892:Milk / Q000378:metabolism*; D010573:Pesticide Residues / Q000032:analysis; D011247:Pregnancy; D011715:Pyrantel / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism*; D011717:Pyrantel Tartrate / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D010573:Pesticide Residues; D011715:Pyrantel; D011717:Pyrantel Tartrate
vernacular_title: Dünnschichromatographische Bestimmung von Pyrantel in Kuhmilch und Blutserum nach peroraler Applikation von Banminth.