Failure of diazepam to affect growth hormone and prolactin in acromegalics.
To demonstrate the effect of diazepam on serum growth hormone and prolactin levels in acromegaly, 7 acromegalics were studied. Every patient received 10 mg diazepam orally at zero time, and blood samples were obtained at 30-min intervals. The same patients also underwent a standard L-dopa test. They were given 500 mg L-dopa orally at zero time, and blood samples were obtained at 30-min intervals. The administration of diazepam did not induce any significant changes in either growth hormone or prolactin levels. On the other hand, the administration of L-dopa resulted in a significant decrease in growth hormone level from 74.25 +/- 22 ng/ml (mean +/- SEM) at zero time to a level of 52.8 +/- 21 and 58.77 +/- 22.7 ng/ml at the 60- and 90-min intervals, respectively (p less than 0.05), and a significant decrease in prolactin level from a baseline of 56.18 +/- 17 to 25.5 +/- 8.4 ng/ml (p less than 0.001) at the 60-min interval. It is suggested that the response of growth hormone to diazepam in acromegalics is qualitatively different from nonacromegalic controls.
D000172:Acromegaly / Q000097:blood* / Q000188:drug therapy; D000328:Adult; D003975:Diazepam / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*
D007980:Levodopa; D011388:Prolactin; D013006:Growth Hormone; D003975:Diazepam