title: Effects of subinhibitory antibiotics on bactericidal activity of chronic granulomatous disease granulocytes in vitro.
abstract: Experiments were performed on leukocytes from patients with chronic granulomatous disease (CGD), incubated with subinhibitory concentrations of antibiotics (clindamycin, methicillin and N-demethyl-lincomycin). Results indicate a minor enhancement of bactericidal activity. This improvement occurred in both CGD homozygotes and one heterozygote and may indicate a future role for the use of low dose antibiotics to augment immune defences such as granulocyte function.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001770:Blood Bactericidal Activity / Q000187:drug effects*; D006098:Granulocytes / Q000187:drug effects*; D006105:Granulomatous Disease, Chronic / Q000097:blood*; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects; D009895:Opsonin Proteins / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D009895:Opsonin Proteins