Induction of sister-chromatid exchanges by alcohol and alcoholic beverages after metabolic activation by rat-liver homogenate.
Samples of alcohol and alcoholic beverages induced SCEs in Chinese hamster ovary cells in the presence of rat-liver homogenate for metabolic activation. SCE tests with acetaldehyde, and measurement of acetaldehyde concentration in tests with alcohol, indicate that SCE induction by alcohol is caused by formation of acetaldehyde.
D000079:Acetaldehyde / Q000032:analysis; D000434:Alcoholic Beverages / Q000633:toxicity*; D000818:Animals; D001711:Biotransformation; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D003434:Crossing Over, Genetic / Q000187:drug effects*; D003520:Cyclophosphamide / Q000633:toxicity; D000431:Ethanol / Q000378:metabolism / Q000633:toxicity*; D005260:Female; D008862:Microsomes, Liver / Q000378:metabolism*; D010053:Ovary; D051381:Rats; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D000431:Ethanol; D003520:Cyclophosphamide; D000079:Acetaldehyde