The transplacental effects of ethanol and metronidazole in Swiss Webster mice.
The fetotoxicity and teratogenicity of metronidazole and ethanol administered alone and together were studied in Swiss Webster mice. We found that both metronidazole and ethanol were mildly fetotoxic and teratogenic when administered alone. However, simultaneous administration of the 2 drugs had an additive effect and resulted in increased fetotoxicity and teratogenicity.
D000818:Animals; D000431:Ethanol / Q000097:blood / Q000633:toxicity*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects; D008431:Maternal-Fetal Exchange; D008795:Metronidazole / Q000633:toxicity*; D051379:Mice; D011247:Pregnancy; D013723:Teratogens
D013723:Teratogens; D008795:Metronidazole; D000431:Ethanol