Anterograde amnesia with oral lorazepam.
The use of intravenous benzodiazepines often results in amnesia for events subsequent to drug administration (anterograde amnesia). To asses the effects of oral administration, a single 2 mg dose of lorazepam was given to 6 normal subjects. No substantial effect on immediate recall of word lists was seen in comparison with 6 placebo control subjects. However, the active drug significantly hindered the delayed recall of words. These findings indicate that lorazepam, taken orally as a daytime tranquilizer, can have amnestic action.
D000284:Administration, Oral; D000328:Adult; D000647:Amnesia / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008140:Lorazepam / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects
D008140:Lorazepam