title: The pupil cycle time in familial dysautonomia. Further evidence for denervation hypersensitivity.
abstract: The pupil cycle time (PCT) was prolonged in 11 subjects with familial dysautonomia. In the younger age group (10-19 years), mean PCT was 872 +/- 88 msec as compared to 15 normal age matched controls (728 +/- 88). In the 3 oldest patients (30-39 years) mean PCT was 980 +/- 133 msec as compared to 13 age matched normals (748 +/- 56). It is proposed that prolongation of PCT in familial dysautonomia may be due to functional denervation of the iris or that it is a result of a structural abnormality of its musculature and/or its neuromuscular junctions.
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D004402:Dysautonomia, Familial / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male; D011680:Pupil / Q000294:innervation / Q000502:physiology*