Morphological changes in organs of mice induced by the combination of adriamycin and pustulan.
In CDF1 mice treated with the combination of pustulan (50 mg/kg) and a low dose of adriamycin (10 mg/kg), the profound changes were noted in the liver. They included both destructive lesions in hepatocytes and the proliferation of the RES. Similar morphological changes, though generally less pronounced, were observed in mice treated with a high dose of adriamycin (20 mg/kg). The myocardial lesions were found in mice treated with the high dose of adriamycin or the combination of pustulan with the low dose of adriamycin. Morphological changes in the myocardium, as opposed to those in the liver were not reversible. No considerable changes were seen in organs of mice treated with pustulan at a dose of 50 mg/kg.
D000818:Animals; D004317:Doxorubicin / Q000008:administration & dosage / Q000633:toxicity*; D004359:Drug Therapy, Combination; D006321:Heart / Q000187:drug effects*; D007939:Leukemia L1210 / Q000188:drug therapy; D008099:Liver / Q000187:drug effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011134:Polysaccharides / Q000008:administration & dosage / Q000633:toxicity*
D011134:Polysaccharides; C002076:pustulan; D004317:Doxorubicin