Middle molecules in the serum, brain, liver and urine of galactosamine-induced fulminant hepatic failure rats.
The middle-molecular weight compounds in the serum, liver, brain and urine were determined in normal and galactosamine-induced grade III coma fulminant hepatic failure (FHF) rats. Peak 7 and subpeak 7g middle molecules increased significantly in the serum of hepatic coma rats. In the brain of grade III coma FHF rats, subpeak 7g increased significantly but peak 7 and other subpeaks decreased significantly. In the liver and urine, both peak 7 and subpeak 7g decreased significantly in grade III coma FHF rats. This rather specific increase of subpeak 7g in the brain corresponding to the increase of subpeak 7g in the serum may contribute to further understanding of the role of middle molecules in hepatic coma.
D000818:Animals; D001923:Brain Chemistry; D002850:Chromatography, Gel; D005688:Galactosamine; D006501:Hepatic Encephalopathy / Q000378:metabolism*; D008099:Liver / Q000032:analysis*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014118:Toxins, Biological / Q000032:analysis*
D014118:Toxins, Biological; C026865:uremia middle molecule toxins; D005688:Galactosamine