In vivo-in vitro correlations for trisulfapyrimidine suspensions.
A UV method is described for measuring total sulfa drug concentration in dissolution samples. This in vitro measurement was found to correlate well with several in vivo parameters obtained after administration of commercial trisulfapyrimidine suspensions to humans. The UV method, which is rapid, simple, inexpensive and easily automated, is recommended for studying the dissolution of trisulfapyrimidine suspensions.
D001682:Biological Availability; D004338:Drug Combinations / Q000032:analysis; D006801:Humans; D008297:Male; D012995:Solubility; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013411:Sulfadiazine / Q000032:analysis*; D013416:Sulfamerazine / Q000032:analysis*; D013418:Sulfamethazine / Q000032:analysis*; D013535:Suspensions; D013997:Time Factors; D000096926:Benzenesulfonamides
D004338:Drug Combinations; D013411:Sulfadiazine; D013416:Sulfamerazine; D013418:Sulfamethazine; D013535:Suspensions; C014873:trisulfapyrimidine; D000096926:Benzenesulfonamides