Hypokalaemia induced by thiazide diuretics in the treatment of hypertension: a cause for concern, not nihilism.
Thiazide diuretics used alone to treat hypertension can cause hypokalaemia in a substantial proportion of patients. The possibility exists that any benefit of reducing high blood pressure by such treatment may be offset by an increased mortality due to arrhythmias initiated by hypokalaemia.
D001145:Arrhythmias, Cardiac / Q000209:etiology; D001581:Benzothiadiazines; D004232:Diuretics; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007008:Hypokalemia / Q000139:chemically induced* / Q000150:complications; D011188:Potassium / Q000627:therapeutic use; D049993:Sodium Chloride Symporter Inhibitors / Q000009:adverse effects*
D001581:Benzothiadiazines; D004232:Diuretics; D049993:Sodium Chloride Symporter Inhibitors; D011188:Potassium