title: Stopping rules for clinical trials.
abstract: We describe a new method of formulating stopping rules for clinical trials, one that incorporates opinion on what difference is clinically important. We compare the method with conventional group sequential designs and illustrate it by application to a study of Pancuronium Bromide for prevention of haemorrhage in pre-term infants.
mesh_terms: D002986:Clinical Trials as Topic; D006801:Humans; D007231:Infant, Newborn; D010197:Pancuronium / Q000627:therapeutic use; D012107:Research Design; D013223:Statistics as Topic; D013810:Therapeutic Equivalency; D006475:Vitamin K Deficiency Bleeding / Q000517:prevention & control
chemical_list: D010197:Pancuronium