title: [Efficacy of doxorubicin (adriamycin) in disseminated forms of breast cancer].
abstract: The efficacy of doxorubicin used alone or in combination with other drugs in chemotherapy of 53 patients with disseminated breast cancer was studied. Doxorubicin combinations with vincristine, cyclophosphamide, 5-fluorouracil and cyclophosphamide, 5-fluorouracil, cyclophosphamide and methotrexate were used. The efficacy of the treatment amounted to 35--50 per cent. Alopecia and hemopoiesis inhibition were the main adverse reactions. Over the past years a new combination of cyclophosphamide, doxorubicin (adriamycin) and cis-platinum was used in the treatment of 45 patients with disseminated breast cancer. The objective effect was observed in 14 patients (38.9 per cent). In 4 of them complete tumor regression was recorded. The administration regimens and side effects of the drugs are described.
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage; D013997:Time Factors; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate
vernacular_title: Effektivnost' doksirubitsina (adriamitsina) pri disseminirovannykh formakh raka molochnoĭ zhelezy.