Influence of psychotomimetics and lisuride on synaptosomal dopamine release in the nucleus accumbens of rats.
In superfusion experiments with a crude synaptosomal fraction from the nucleus accumbens of rats, lysergic acid diethylamide, mescaline and N,N-dimethyltryptamine (representing different chemical classes of psychotomimetics) produced a concentration-related inhibition of K+-evoked [3H]dopamine release whereas spontaneous release remained unchanged. The nonpsychotomimetic ergoline lisuride tested at the same concentration range did not modulate spontaneous or K+-evoked [3H]dopamine release. The inhibitory effects of the psychotomimetics tested were antagonized by equal concentrations of haloperidol or methiothepine. It is postulated that the effects of psychotomimetics on DA release were triggered via simultaneous action at presynaptic dopamine and 5-hydroxytryptamine receptors which are located at dopamine nerve endings in the nucleus accumbens.
D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D004873:Ergolines / Q000494:pharmacology*; D006213:Hallucinogens / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D066298:In Vitro Techniques; D008090:Lisuride / Q000494:pharmacology*; D008297:Male; D008635:Mescaline / Q000494:pharmacology; D008719:Methiothepin / Q000494:pharmacology; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D009714:Nucleus Accumbens / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000378:metabolism*; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
D004873:Ergolines; D006213:Hallucinogens; D008996:Monoamine Oxidase Inhibitors; D008719:Methiothepin; D008090:Lisuride; D006220:Haloperidol; D008635:Mescaline; D004298:Dopamine