Parasympathethic effects on diet-induced thermogenesis.
Injection of atropine methyl nitrate or atropine sulphate enhanced the acute thermogenic response to food in rats. The main effector of diet-induced thermogenesis is brown adipose tissue (BAT), but acetylcholine (determined by bioassay) and acetylcholinesterase activity (determined histochemically) were not detected in BAT. This suggests that BAT has no parasympathetic innervation, and atropine must therefore act elsewhere to affect thermogenesis.
D000110:Acetylcholinesterase / Q000378:metabolism; D002001:Adipose Tissue, Brown / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001286:Atropine Derivatives / Q000494:pharmacology; D001833:Body Temperature Regulation / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D002802:Cholinesterases / Q000378:metabolism; D004032:Diet; D006168:Guinea Pigs; D008297:Male; D009197:Myenteric Plexus / Q000187:drug effects / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D010275:Parasympathetic Nervous System / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains
D001286:Atropine Derivatives; D001285:Atropine; C006649:methylatropine; D000110:Acetylcholinesterase; D002802:Cholinesterases