Clotting activity in the rat following acute barbiturate treatment.
Adult male rats were subjected to intraperitoneal (i.p.) saline (controls) or barbiturates (20 mg/rat) as a single injection. Seventeen hours later the rats were sacrificed and plasma collected. Hematocrit (HCT), Platelet count (PLT), prothrombin time (PT), partial thromboplastin time (APTT), and coagulant activity for factors II, V, VII, VIII, X and XII, plus fibrinogen were determined. The data indicates that a single injection of phenobarbital and secobarbital had a greater effect on clotting activity than did barbital or amobarbital. This was primarily reflected in the hepatic synthesized clotting factors, plus the platelets.
D000654:Amobarbital / Q000633:toxicity; D000818:Animals; D001462:Barbital / Q000633:toxicity; D001463:Barbiturates / Q000633:toxicity*; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors / Q000502:physiology; D006400:Hematocrit; D008297:Male; D010314:Partial Thromboplastin Time; D010634:Phenobarbital / Q000633:toxicity; D010976:Platelet Count; D011517:Prothrombin Time; D051381:Rats; D011919:Rats, Inbred Strains; D012631:Secobarbital / Q000633:toxicity
D001463:Barbiturates; D001779:Blood Coagulation Factors; D012631:Secobarbital; D001462:Barbital; D000654:Amobarbital; D010634:Phenobarbital