Stress causes reduced natural killer activity in mice.
The natural killer (NK) activity of spleen cells from C57B1/10 mice subjected to standardized stress conditions was reduced when compared with that of untreated controls. Both the total number of nucleated spleen cells and their cytotoxic activity against an NK-sensitive target were reduced. The reduction appeared after induction of stress, and the NK activity was reduced throughout an 8-day stress period.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D007108:Immune Tolerance; D007694:Killer Cells, Natural / Q000276:immunology*; D007700:Kinetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000166:cytology / Q000276:immunology; D013312:Stress, Physiological / Q000276:immunology*