Interaction of Clostridium difficile toxins and mouse hepatic microsomes.
Intraperitoneal administration of toxins of Clostridium difficile to mice resulted in loss of hepatic cytochrome P450 and peroxidation of microsomal lipids. Pretreatment with the microsomal enzyme inducer beta-naphthoflavone partially alleviated these effects and increased survival time of intoxicated animals.
D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D003013:Clostridium; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003573:Cytochrome b Group / Q000378:metabolism; D003580:Cytochromes / Q000378:metabolism; D015786:Cytochromes b5; D008054:Lipid Peroxides / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000096:biosynthesis; D051379:Mice; D008813:Mice, Inbred ICR; D008862:Microsomes, Liver / Q000378:metabolism*
D001427:Bacterial Toxins; D003573:Cytochrome b Group; D003580:Cytochromes; D008054:Lipid Peroxides; D008315:Malondialdehyde; D015786:Cytochromes b5; C013464:cytochrome P420; D003577:Cytochrome P-450 Enzyme System