Elevated levels of a 17-kilodalton nuclear protein in carcinomas.
The presence of a 17-kilodalton nuclear protein with pI variants of 6.7-6.9 in solid human malignant tumors is reported. This protein was more prominent in the carcinomas sampled compared to the sarcomas studied. Small amounts were detectable in placenta, but not in adult human liver, suggesting that the protein may be the product of a gene involved in normal differentiation.
D000230:Adenocarcinoma / Q000032:analysis; D002277:Carcinoma / Q000032:analysis*; D002467:Cell Nucleus / Q000032:analysis*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D008099:Liver / Q000032:analysis; D008970:Molecular Weight; D009363:Neoplasm Proteins / Q000032:analysis*; D010920:Placenta / Q000032:analysis; D012509:Sarcoma / Q000032:analysis
D009363:Neoplasm Proteins