title: [Tumor recurrence and massive cerebral angiofibrosis 28 years after conventional high-dose radiotherapy of prolactinoma].
abstract: A fatal recurrence developed 28 years after conventional X-ray therapy of a hypophyseal adenoma with a focal dose of 10340R. An organic psychosyndrome of many years preceded the recurrence. The immunocytologic examination of the recurrent tumor showed a prolactinoma. As radiogenic fibroses without primary parenchyma necrosis, massive angiofibroses within tumor, hypothalamus, and neostriatum and less massive angiofibroses in the cerebrum and cortex of cerebrum are opposed to the classical late radiation damage with plasmatic infiltration necrosis.
mesh_terms: D000328:Adult; D002561:Cerebrovascular Disorders / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D019965:Neurocognitive Disorders / Q000209:etiology; D010911:Pituitary Neoplasms / Q000532:radiotherapy*; D011388:Prolactin / Q000378:metabolism*; D011832:Radiation Injuries / Q000175:diagnosis*; D013997:Time Factors
chemical_list: D011388:Prolactin
vernacular_title: Tumorrezidiv und massive zerebrale Angiofibrose 28 Jahre nach hochdosierter konventioneller Strahlentherapie eines Prolaktinoms.