[Antibacterial peptides (18). Synthesis and antibacterial activity of alpha-acyltetrapeptides containing basic amino acids (7)].
Three kinds of (formula; see text) were synthesized to investigate the relationship between the chemical structure and the antibacterial activities by acylation of the corresponding tetrapeptides. Acyl chlorides of (+)-6-Methyloctanoic acid (a component of colistin) and two kinds of other organic acid were employed as acylating agents. It was proved that one of three, (formula; see text) shows antibacterial activity against four kinds of Gram-negative bacteria and against Gram-positive bacteria, but that the other only have weak antibacterial activity.
D055598:Chemical Phenomena; D002621:Chemistry; D004352:Drug Resistance, Microbial; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D010455:Peptides / Q000032:analysis / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D010455:Peptides