Increased weight gain and reduced activity in brown adipose tissue produced by depletion of hypothalamic noradrenaline.
The effects of hypothalamic noradrenaline depletion produced by injection of 6-hydroxydopamine (6-OHDA) into the vicinity of cell bodies of the ventral noradrenergic bundle (VNAB) on weight gain, food intake and brown adipose tissue (BAT) activity (as measured by GDP binding in BAT mitochondria), were examined in rats at two different ages and under two different dietary conditions (chow and chow plus palatable cheese). VNAB lesions enhanced weight gain in the chow plus cheese diet conditions and produced small increases in feeding. These effects were parallelled by reductions in BAT activity in the VNAB group, suggesting a reduced capacity for dietary thermogenesis which may contribute to the significant overweight.
D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000375:Aging; D000818:Animals; D001833:Body Temperature Regulation; D001835:Body Weight; D004435:Eating; D004734:Energy Metabolism; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D009638:Norepinephrine / Q000172:deficiency*; D051381:Rats; D011919:Rats, Inbred Strains
D009638:Norepinephrine