Phencyclidine decreases methionine-enkephalin content in rat striatum.
The acute administration of phencyclidine induced a decrease in methionine-enkephalin levels in rat striatum, as measured by specific radioimmunoassay. The maximum decrease (about 40% with respect to controls) was obtained at a dose of 20 mg/kg, 30 min after intraperitoneal injection. These results suggest a possible involvement of enkephalins in the central effects of phencyclidine.
D000818:Animals; D003342:Corpus Striatum / Q000032:analysis*; D004305:Dose-Response Relationship, Drug; D004744:Enkephalin, Methionine / Q000032:analysis*; D008297:Male; D010622:Phencyclidine / Q000494:pharmacology*; D011863:Radioimmunoassay; D051381:Rats / Q000378:metabolism*; D011919:Rats, Inbred Strains
D004744:Enkephalin, Methionine; D010622:Phencyclidine