title: Notochordal anomaly in frog embryos exposed to tetraethylthiuram monosulphide and tetraethylthiuram disulphide.
abstract: Gastrulating embryos of the frog Microhyla ornata were treated with tetraethylthiuram monosulphide (TETM) and tetraethylthiuram disulphide (TETD) for 48-96 h. It was observed that both chemicals induce severe notochordal abnormalities at very low concentration. The notochord in abnormal embryos was highly swollen and entirely wavy. The notochordal cells were swollen and disarrayed. The embryos were also highly oedematous and there was considerable disarray of other tissues due to the abnormal notochord.
mesh_terms: D000818:Animals; D001001:Anura / Q000196:embryology; D004221:Disulfiram / Q000031:analogs & derivatives* / Q000633:toxicity*; D004625:Embryo, Nonmammalian / Q000187:drug effects*; D009672:Notochord / Q000187:drug effects*; D013723:Teratogens
chemical_list: D013723:Teratogens; C009822:monosulfiram; D004221:Disulfiram