[Synthesis and spectrum of pharmacologic action of aryl-arylamino- and aryl-aryliminoacetonitriles].
Aminoacetonitriles were synthetized from arylaldehyde, arylamine and cyanhydrogene. Their dehydrogenation led to the iminoderivatives. The compounds were evaluated for spasmolytic activity in vitro. Some aryl-arylaminoacetonitriles showed significant inhibition of the histamine-induced contraction in guinea-pig ileum and acetylcholine-induced contraction in rat ileum. Structure-activity relationships are discussed.
D000097:Acetonitriles / Q000138:chemical synthesis* / Q000494:pharmacology; D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006633:Histamine Antagonists / Q000138:chemical synthesis; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D010276:Parasympatholytics / Q000138:chemical synthesis*; D051381:Rats; D013329:Structure-Activity Relationship
D000097:Acetonitriles; D006633:Histamine Antagonists; D010276:Parasympatholytics; D006632:Histamine; D000109:Acetylcholine
Synthese und pharmakologisches Wirkungsspektrum von Aryl-arylamino- und Aryl-aryliminoacetonitrilen.