Different effects of subcutaneous D,L-3-hydroxybutyrate and acetoacetate injections on food intake in rats.
Cumulative food intake following subcutaneous injection of D,L-3-hydroxybutyrate (DL3HB) or acetoacetate (AcAc) was investigated in rats, because ketone bodies might contribute to food intake regulation according to Kennedy's lipostatic hypothesis. In addition, the metabolic effects of DL3HB-injections were studied by measuring the levels of plasma D3HB, plasma non-esterified fatty acids (NEFA), plasma glycerol, blood glucose, and liver glycogen. Subcutaneously injected DL3HB (10 mmoles/kg body weight) significantly reduced feeding while equimolar AcAc did not. DL3HB-injection increased plasma D3HB and decreased plasma NEFA and plasma glycerol 1-2 hours after the injection but did not affect blood glucose or liver glycogen content. The data suggest that oxidation of D3HB to AcAc contributes to the inhibition of feeding following subcutaneous DL3HB-injection in rats.
D020155:3-Hydroxybutyric Acid; D000090:Acetoacetates / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002087:Butyrates / Q000494:pharmacology; D004435:Eating / Q000187:drug effects*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005990:Glycerol / Q000097:blood; D006885:Hydroxybutyrates / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D007657:Ketone Bodies; D008112:Liver Glycogen / Q000097:blood; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000090:Acetoacetates; D001786:Blood Glucose; D002087:Butyrates; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; D007657:Ketone Bodies; D008112:Liver Glycogen; C016635:acetoacetic acid; D005990:Glycerol; D020155:3-Hydroxybutyric Acid