title: Dynamics of the interventricular septum and free ventricular walls during selective left ventricular volume loading in dogs.
abstract: A previous study suggests that a change in the position of the interventricular septum played an important role in regulating cardiac performance during selective right ventricular volume loading. In the present study the cardiac response to selective left ventricular volume loading induced by a shunt between the subclavian artery and the left atrium was examined in anesthetized open-chest dogs. Opening the shunt increased left and reduced right ventricular stroke volume, particularly after blood volume expansion. The end-diastolic transseptal pressure difference increased. Myocardial segment length in the septum and free walls of both ventricles and the distances between the septum and the free walls were measured by an ultrasonic technique. Comparisons at similar left ventricular stroke volume with the shunt open and closed showed that the Frank-Starling mechanisms of the free wall of the left ventricle and the septum were stimulated less with the shunt open. At similar right ventricular stroke volume the end-diastolic dimension of the right ventricular free wall was larger with the shunt open. The distance decreased across the right ventricle and increased across the left ventricle when the shunt was open. We conclude that a change in the position of the septum improves left and reduces right ventricular performance during selective left ventricular volume loading.
mesh_terms: D000818:Animals; D016275:Atrial Function; D001794:Blood Pressure; D001810:Blood Volume; D003971:Diastole; D004285:Dogs; D006346:Heart Septum / Q000502:physiology*; D006439:Hemodynamics; D013318:Stroke Volume; D013348:Subclavian Artery / Q000502:physiology; D014463:Ultrasonography; D016276:Ventricular Function