Ocular Candida with pale-centered hemorrhages.
A 54-year-old man with severe thermal burns had Candida corneal ulcers and Candida septicemia develop, and he died 39 days after admission to the hospital. At autopsy examination, fungi were noted in the cornea to extend across the intact Descemet's membrane and were also found within foci of retinitis and choroiditis. Also, hemorrhages (some of which had pale centers) were present in both retinas. Histopathologic examination of these hemorrhages disclosed that the pale centers were comprised of a disrupted small blood vessel surrounded by an acellular material that most likely represented fibrin-platelet aggregates.
D002175:Candida / Q000302:isolation & purification*; D002177:Candidiasis / Q000382:microbiology / Q000473:pathology*; D002833:Choroiditis / Q000209:etiology; D003315:Cornea / Q000382:microbiology*; D003320:Corneal Ulcer / Q000209:etiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012166:Retinal Hemorrhage / Q000209:etiology* / Q000473:pathology; D012173:Retinitis / Q000209:etiology