Effect of the nonionic surfactant poloxamer 338 on the fate and deposition of polystyrene microspheres following intravenous administration.
The blood clearance and organ deposition of polystyrene microspheres in the rabbit following intravenous injection has been investigated using the technique of gamma scintigraphy, blood and organ level measurements, and histology. Uncoated microspheres of 1.27-microns diameter were cleared rapidly from the blood and were taken up primarily by the reticuloendothelial system in the liver. Coating of the microspheres with the nonionic surface-active agent poloxamer 338 reduced the uptake in the liver and gave a corresponding increase in the lungs.
D000818:Animals; D008863:Microspheres; D010316:Particle Size; D011060:Poloxalene; D011092:Polyethylene Glycols; D011137:Polystyrenes / Q000008:administration & dosage; D011817:Rabbits; D013997:Time Factors; D014018:Tissue Distribution
D011137:Polystyrenes; D011092:Polyethylene Glycols; D011060:Poloxalene