Comparison of the immunogenic effects of covalent-bonded immune complexes in mice and sheep.
Covalent antigen-antibody complexes containing the protein antigen ovo-transferrin primed both mice and sheep to give an enhanced antibody response to a subsequent single injection of soluble ovo-transferrin. Complexes prepared using horse, sheep or rabbit antibody had a priming effect in mice, although rabbit antibody-antigen complexes were the most effective. In sheep, only rabbit antibody-antigen complexes significantly enhanced antibody levels.
D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D000936:Antigen-Antibody Complex / Q000276:immunology*; D003207:Conalbumin / Q000276:immunology*; D004527:Egg Proteins / Q000276:immunology*; D005260:Female; D006736:Horses / Q000276:immunology; D008297:Male; D051379:Mice / Q000276:immunology*; D008808:Mice, Inbred CBA; D011817:Rabbits / Q000276:immunology; D012756:Sheep / Q000276:immunology*
D000276:Adjuvants, Immunologic; D000936:Antigen-Antibody Complex; D004527:Egg Proteins; D003207:Conalbumin