Successful praziquantel treatment of paragonimiasis following bithionol failure. A case report.
A patient from Southeast Asia with cough and hemoptysis was documented to have pulmonary paragonimiasis. Initial treatment with bithionol failed. The patient was then treated with praziquantel 75 mg/kg body weight a day for 2 days under an investigational protocol. Subsequent follow-up studies showed clinical improvement and indicated parasitologic cure. A concurrent asymptomatic Clonorchis infection was also cured following praziquantel treatment. Side effects were minor.
D000328:Adult; D001735:Bithionol / Q000627:therapeutic use*; D003003:Clonorchiasis / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007546:Isoquinolines / Q000627:therapeutic use*; D008174:Lung Diseases, Parasitic / Q000188:drug therapy*; D008297:Male; D010237:Paragonimiasis / Q000150:complications / Q000188:drug therapy*; D010636:Phenols / Q000627:therapeutic use*; D011223:Praziquantel / Q000009:adverse effects / Q000627:therapeutic use*
D007546:Isoquinolines; D010636:Phenols; D011223:Praziquantel; D001735:Bithionol