Stimulation of peroxidase reactions by hydroxamates.
Salicylhydroxamic acid, benzohydroxamic acid, and phenylacetohydroxamic acid were found to stimulate the oxidation of NADH, dithiothreitol, and ferrocyanide by horseradish peroxidase. The hydroxamates themselves served as substrates in peroxidase reactions, and the observed stimulations may involve hydroxamate free-radical formation.
D004789:Enzyme Activation; D006735:Horseradish Peroxidase / Q000378:metabolism*; D006877:Hydroxamic Acids / Q000494:pharmacology*; D007700:Kinetics; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction; D010544:Peroxidases / Q000378:metabolism*; D013329:Structure-Activity Relationship
D006877:Hydroxamic Acids; D009243:NAD; D006735:Horseradish Peroxidase; D010544:Peroxidases