Protamine inhibits adenylate cyclase activity: a possible reason for the toxicity of protamine.
Protamine is an effective inhibitor of the various activated forms of adenylate cyclase of liver plasma membranes. Inhibition of adenylate cyclase may account for its toxic but not its antitumor effects.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000067956:Adenylyl Cyclase Inhibitors; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D006165:Guanylyl Imidodiphosphate / Q000494:pharmacology; D008099:Liver / Q000201:enzymology*; D011479:Protamines / Q000494:pharmacology* / Q000633:toxicity; D012969:Sodium Fluoride / Q000494:pharmacology
D000067956:Adenylyl Cyclase Inhibitors; D011479:Protamines; D006165:Guanylyl Imidodiphosphate; D000255:Adenosine Triphosphate; D012969:Sodium Fluoride