Effects of subinhibitory antibiotics on bactericidal activity of chronic granulomatous disease granulocytes in vitro.
Experiments were performed on leukocytes from patients with chronic granulomatous disease (CGD), incubated with subinhibitory concentrations of antibiotics (clindamycin, methicillin and N-demethyl-lincomycin). Results indicate a minor enhancement of bactericidal activity. This improvement occurred in both CGD homozygotes and one heterozygote and may indicate a future role for the use of low dose antibiotics to augment immune defences such as granulocyte function.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D001770:Blood Bactericidal Activity / Q000187:drug effects*; D006098:Granulocytes / Q000187:drug effects*; D006105:Granulomatous Disease, Chronic / Q000097:blood*; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects; D009895:Opsonin Proteins / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D009895:Opsonin Proteins