Resetting of the baroreceptors by atenolol in the anaesthetized cat.
In anaesthetized cats, atenolol (3 mg X kg-1 i.v.) produced an immediate reduction in blood pressure, heart rate and aortic nerve discharge. However, 30 min and 60 min after atenolol there was a shift to the left of the curve relating aortic nerve discharge to mean arterial blood pressure indicating a delayed resetting of the baroreceptors. There was no evidence that atenolol altered the sensitivity of the baroreceptors.
D000768:Anesthesia, General; D000818:Animals; D001262:Atenolol / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D002415:Cats; D005260:Female; D008297:Male; D009474:Neurons / Q000187:drug effects; D011311:Pressoreceptors / Q000187:drug effects*
D001262:Atenolol