Long-term follow-up of patients receiving aprindine. Safety and efficacy.
Aprindine hydrochloride is an antiarrhythmic agent presently undergoing clinical trials in the United States. Because of the narrow therapeutic-toxic ratio observed for aprindine, the long-term follow-up of these patients is important in determining the potential clinical effectiveness of this drug. In this report we examine our experience with 30 patients with drug-resistant arrhythmias who were discharged receiving aprindine and who were followed up for a mean period of 25 months.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001073:Aprindine / Q000008:administration & dosage* / Q000592:standards; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007192:Indenes / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged
D007192:Indenes; D001073:Aprindine