Dual effects of calcium on the oxidation of fatty acids to ketone bodies in liver mitochondria.
The addition of calcium ions (Ca2+) to rat liver mitochondria, under conditions of rapid accumulation of 10-40 nmol Ca2+/mg protein, inhibited the oxidation of long and medium chain fatty acids to ketone bodies, whereas higher quantities of Ca2+ activated the process. The mitochondrial NADH:NAD ratio exhibited corresponding depression and elevation. Both inhibitory and stimulatory actions of Ca2+ were operative in liver mitochondria from fed and fasted rats and appear to be localized in the mitochondrial inner membrane-matrix region. These observations may signify involvement of Ca2+ in the regulation of fatty acid oxidation and ketogenesis.
D000818:Animals; D001692:Biological Transport; D002118:Calcium / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism*; D005508:Food Deprivation; D007425:Intracellular Membranes / Q000378:metabolism; D007657:Ketone Bodies / Q000096:biosynthesis*; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D009243:NAD / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats
D005227:Fatty Acids; D007657:Ketone Bodies; D009243:NAD; D002118:Calcium