Effect of dimethoate and O-demethyldimethoate on bone marrow cells of CFLP mice.
The organophosphorus pesticide dimethoate and its nonalkylating O-demethyl derivative were tested for their ability to induce chromosomal alterations in bone marrow cells of CFLP mice after ip administration. A single dose of 20 mg/kg dimethoate proved to be ineffective. However, doses of 60 mg/kg dimethoate or 69 mg/kg O-demethyldimethoate sodium salt significantly increased the aberration rates above those of the controls. The same effect was observed after a nontoxic dose of 690 mg/kg O-demethyldimethoate sodium salt. Considering the distribution of the several aberration types, these findings suggest that the alkylating properties of dimethoate only in part may be responsible for its cytogenetic activity.
D000478:Alkylation; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000648:ultrastructure; D002869:Chromosome Aberrations; D004117:Dimethoate / Q000031:analogs & derivatives* / Q000633:toxicity*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
C040049:O-demethyldimethoate; D004117:Dimethoate