A fragile X suppressor in the normal human blood?
Eberle et al. (1981, 1982a) reported diminished proportion of fragile X chromosomes in co-cultures of blood cells taken from fra(X) patients with normal blood cells. However, we did not observe any suppression of fra(X) in the blood of fra(X)-positive patients after co-cultivation with blood of fra(X)-negative subjects. Neither was any suppression caused by medium where fra(X)-negative cells had been previously cultivated for two days.
D002478:Cells, Cultured; D002873:Chromosome Fragility; D005600:Fragile X Syndrome / Q000097:blood / Q000235:genetics*; D006801:Humans; D008297:Male; D012729:Sex Chromosome Aberrations / Q000235:genetics*; D013489:Suppression, Genetic