[Use of phenobarbital by the oral route in the acute and maintenance treatment of convulsions in children].
Early and long-lasting phenobarbital plasma levels were obtained by the following schedule in children presenting with convulsions who remained at risk for early relapse: a load dose of 15 mg/kg, followed 12 hours later by the administration of 5 mg/kg in children under 1 year of age and 3 mg/kg in older children; further maintenance doses were 3 mg/kg every 24 hours for 10 days in all children. No child presented with any convulsion in the period of time studied. The mean phenobarbital plasma levels were, from the 1st to the 88th hour, between the values considered as effective (12.6 and 22.3 mg/l). These values were always lower in children under 1 year of age, except for the 1st hour.
D000284:Administration, Oral; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007700:Kinetics; D008297:Male; D010634:Phenobarbital / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D012640:Seizures / Q000188:drug therapy*
D010634:Phenobarbital
Utilisation du phénobarbital par voie orale dans le traitement d'attaque et d'entretien des crises convulsives de l'enfant.