Role of nigral dopamine in amphetamine-induced locomotor activity.
Dopamine (100 micrograms) injected into the substantia nigra pars reticulata of rats pretreated with the monoamine oxidase inhibitor, pargyline, resulted in a stimulation of locomotor activity. Bilateral injection of the dopamine antagonist haloperidol (5 micrograms) into the substantia nigra pars reticulata resulted in a reduction of the locomotor activity evoked by a low dose of amphetamine (1.25 mg/kg s.c.). These results suggest that the release of dopamine from nigral dendrites is involved in amphetamine-induced locomotor activity.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D004298:Dopamine / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000502:physiology*
D000661:Amphetamine; D006220:Haloperidol; D004298:Dopamine