First experimental and clinical results of isolated liver perfusion with cytotoxics in metastases from colorectal primary.
In two patients suffering from numerous liver metastases in both lobes from colorectal primary isolated liverperfusion with 5-fluorouracil was performed. By means of a special cannulation system the hepatic artery and the portal vein were arterialized. The patients recovered rapidly after the operation. Sonographic measurements, CAT scans, pulse cytophotometry, and second-look operations with histological examinations of metastatic tissue verified extensive tumor regression. No complications occurred within 6 months after the perfusion treatment.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002404:Catheterization / Q000295:instrumentation; D010478:Chemotherapy, Cancer, Regional Perfusion / Q000295:instrumentation*; D003110:Colonic Neoplasms / Q000188:drug therapy*; D003606:Dacarbazine / Q000627:therapeutic use; D004285:Dogs; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008727:Methotrexate / Q000627:therapeutic use; D012004:Rectal Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents; D003606:Dacarbazine; D005472:Fluorouracil; D008727:Methotrexate