[The role of endogenous glutathione in the action of sulfur-containing radio-protectors].
In experiments on Ehrlich ascite tumor cells, the dependence of the radioprotective effect of beta-mercaptoethylamine and beta-mercaptopropionylglycine on the initial level of endogenous glutathione was studied. A varying degree of N-ethylmaleimide induced decrease of SH-glutathione content in the cells led to either easing or elimination of the radioprotective effect of the agents under study.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism / Q000532:radiotherapy*; D004307:Dose-Response Relationship, Radiation; D005978:Glutathione / Q000378:metabolism*; D008624:Mercaptoethylamines / Q000494:pharmacology; D051379:Mice; D011836:Radiation Tolerance; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D008625:Tiopronin / Q000494:pharmacology
D008624:Mercaptoethylamines; D011837:Radiation-Protective Agents; D008625:Tiopronin; D005978:Glutathione
Uchastie éndogennogo gliutationa v deĭstvii serosoderzhashchikh radioprotektorov.