A new, reliable lower-body nociception device for unrestrained animals yields data comparable to a new portable version of the face-rub test.
A novel lower body heating device is described for use in lower body analgesiometry with freely-moving, small animals. It consists of a resistor in contact with a hindlimb. The defensive biting response to heat shows reliable dose-response effects with morphine which compare well with our similar upper body device (Rosenfeld et al. 1978). Issues dealing with upper versus lower body nociception effects may be tested with the new device set described.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004924:Escape Reaction; D006361:Heating / Q000295:instrumentation*; D006614:Hindlimb / Q000503:physiopathology*; D009020:Morphine / Q000008:administration & dosage; D010146:Pain / Q000503:physiopathology*; D051381:Rats; D011930:Reaction Time; D013697:Thermosensing
D009020:Morphine