title: B-ring aromatization of estrogen derivatives.
abstract: A novel method of B-ring aromatization of steroid derivatives is reported. Addition of BrCl in methanol to a non-aromatic B-ring double bond results in a rapid double elimination generating the aromatic B-ring. This procedure represents an effective method for conversion of an equilin to an equilenin nucleus.
mesh_terms: D001965:Bromides; D055598:Chemical Phenomena; D002621:Chemistry; D002712:Chlorides; D004967:Estrogens; D007202:Indicators and Reagents; D013329:Structure-Activity Relationship
chemical_list: D001965:Bromides; D002712:Chlorides; D004967:Estrogens; D007202:Indicators and Reagents; C016271:bromine chloride