[Plasma glycerol and hepatic synthesis of lipoproteins in the Zucker fa/fa rat].
In order to determine if excess plasma glycerol originating in lipolysis increased the synthesis and secretion of lipoproteins in the liver of Zucker fa/fa rats, labelled (1-14C) glycerol was injected in vivo in the jugular vein, in the presence of (9,10-3H20 oleic acid and Triton WR 1339 to block plasma clearance of neoformed lipoproteins and to be secreted into the blood by the liver. Glycerol stimulated hepatic synthesis of lipids in the Zucker fa/fa rat. This resulted in an increased secretion by the liver of VLDL and lipoproteins comparable to chylomicrons.
D000818:Animals; D005990:Glycerol / Q000097:blood*; D008066:Lipolysis; D008074:Lipoproteins / Q000096:biosynthesis*; D008079:Lipoproteins, VLDL / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D011924:Rats, Zucker
D008074:Lipoproteins; D008079:Lipoproteins, VLDL; D005990:Glycerol
Glycérol plasmatique et synthèse hépatique des lipoprotéines chez le rat Zucker fa/fa.