[Use of beta-aminoethylmethacrylate in traumatic paralysis of the sciatic nerve].
It has been discovered in experiments on rats with traumatic paralysis of the sciatic nerve that a methacrylic acid derivative, beta-aminoethylmethacrylate (AEM), displays marked neurotropic, particularly strychnine-like activity. Using visual, electrophysiological and biochemical research methods it has been demonstrated that the substance has a normalizing action on the function of the neuromuscular apparatus in paralysis and that this action is more powerful than that produced by strychnine, securinine, proserine, dibasol, thiamine, and cyanocobalamin. AEM has a beneficial effect on metabolism of the muscles of an injured limb, raising in them the content of glycogen and decreasing the activity of succinate dehydrogenase and acid phosphatase since the first day after trauma. The drug does not only accelerates the progress of the recovery but also reduced a direct effect of nervous trunk injury on the muscle.
D000179:Acrylates / Q000627:therapeutic use*; D000470:Alkaloids / Q000627:therapeutic use; D000818:Animals; D001381:Azepines; D001562:Benzimidazoles / Q000627:therapeutic use; D002907:Chronaxy / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004558:Electric Stimulation; D006576:Heterocyclic Compounds, 4 or More Rings; D006572:Heterocyclic Compounds, Bridged-Ring; D007783:Lactones; D008297:Male; D008689:Methacrylates / Q000627:therapeutic use*; D009388:Neostigmine / Q000627:therapeutic use*; D010243:Paralysis / Q000188:drug therapy*; D010880:Piperidines; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects / Q000293:injuries*; D013331:Strychnine / Q000627:therapeutic use; D013831:Thiamine / Q000627:therapeutic use; D014805:Vitamin B 12 / Q000627:therapeutic use
D000179:Acrylates; D000470:Alkaloids; D001381:Azepines; D001562:Benzimidazoles; D006576:Heterocyclic Compounds, 4 or More Rings; D006572:Heterocyclic Compounds, Bridged-Ring; D007783:Lactones; D008689:Methacrylates; D010880:Piperidines; C004453:bendazole; D009388:Neostigmine; C000785:securinine; D013331:Strychnine; D014805:Vitamin B 12; D013831:Thiamine
Primenenie beta-aminoétilmetakrilata pri travmaticheskom paraliche sedalishchnogo nerva.