title: Cancer mortality among coke oven workers.
abstract: The OSHA standard for coke oven emissions, which went into effect in January 1977, sets a permissible exposure limit to coke oven emissions of 150 micrograms/m3 benzene-soluble fraction of total particulate matter (BSFTPM). Review of the epidemiologic evidence for the standard indicates an excess relative risk for lung cancer as high as 16-fold in topside coke oven workers with 15 years of exposure or more. There is also evidence for a consistent dose-response relationship in lung cancer mortality when duration and location of employment at the coke ovens are considered. Dose-response models fitted to these same data indicate that, while excess risks may still occur under the OSHA standard, the predicted levels of increased relative risk would be about 30-50% if a linear dose-response model is assumed and 3-7% if a quadratic model is assumed. Lung cancer mortality data for other steelworkers suggest the predicted excess risk has probably been somewhat overestimated, but lack of information on important confounding factors limits further dose-response analysis.
mesh_terms: D003031:Coal / Q000009:adverse effects*; D003033:Coal Tar / Q000009:adverse effects*; D003077:Coke / Q000009:adverse effects*; D004067:Digestive System Neoplasms / Q000139:chemically induced / Q000401:mortality; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000139:chemically induced / Q000401:mortality*; D009784:Occupational Diseases / Q000139:chemically induced / Q000401:mortality*; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced / Q000401:mortality; D012306:Risk
chemical_list: D003031:Coal; D003077:Coke; D003033:Coal Tar