Epinephrine-induced cardiac arrhythmias in rabbits exposed to tetrachloroethylene.
Control rabbits or those treated with 2,4-dichloro-6-phenylphenoxyethyldiethylamine-HBr (Lilly 18947), an inhibitor of microsomal mixed-function oxidases, were exposed to 5200 ppm tetrachloroethylene in an inhalation chamber under dynamic airflow conditions for 1 h. Even at this high concentration, tetrachloroethylene was only weakly arrhythmogenic when animals were challenged with up to 3 micrograms/kg epinephrine i.v. Unlike trichloroethylene and methylchloroform, the arrhythmogenicity of tetrachloroethylene was not potentiated by treatment with Lilly 18947.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D001713:Biphenyl Compounds / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System; D004347:Drug Interactions; D004837:Epinephrine / Q000633:toxicity*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors; D011817:Rabbits; D013750:Tetrachloroethylene / Q000378:metabolism / Q000633:toxicity*
D001713:Biphenyl Compounds; C002109:Lilly 18947; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D013750:Tetrachloroethylene; D004837:Epinephrine