title: Ventilation-perfusion relationships during epidural analgesia.
abstract: Resting lung volume (FRC), airway closure (CC) and ventilation-perfusion relationships, using the multiple inert gas elimination technique, were studied during epidural analgesia. The material consisted of 10 patients, 55-84 years of age. Epidural blockade (9-13 ml mepivacaine-adr, 1/200,000) was instituted to an upper level corresponding to Th3-Th6. Minute ventilation and breathing frequency remained unchanged during the epidural block, while cardiac output was significantly increased (4.80-5.74 l/min). The relationship between FRC and CC (FRC-CC) was unchanged during the block, indicating an unchanged magnitude of airway closure. Multiple inert gas elimination data revealed virtually unchanged distribution of ventilation and perfusion during the epidural block in 9 of the 10 patients. It is concluded that lumbar epidural analgesia up to Th3-Th6 does not influence the degree of airway closure, nor does it cause VA/Q mismatching as general anaesthesia does.
mesh_terms: D000368:Aged; D000767:Anesthesia, Epidural; D005260:Female; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D008875:Middle Aged; D012119:Respiration / Q000187:drug effects; D014692:Ventilation-Perfusion Ratio