[Effects of sidnocarb on hemodynamics and blood redistribution during functional tests after 6-hour antiorthostatic hypokinesis].
Man's orthostatic tolerance and physical work capacity declined in response to 6-hour head-down tilt at -15 degrees. During tilt tests heart rate increased, blood pressure fell, and blood pooling in the upper body decreased. During exercise tests the circulating blood volume, total amount of the work performed, and consumed oxygen decreased. Sydnocarb given at a dose of 25 mg during head-down tilt did not influence the circulating blood volume and oxygen consumption. All other parameters varied approaching the pretest values.
D000328:Adult; D001775:Blood Circulation / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D004562:Electrocardiography; D005080:Exercise Test; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007103:Immobilization; D008297:Male; D010069:Oxadiazoles / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D011187:Posture; D013558:Sydnones / Q000494:pharmacology*; D013997:Time Factors
D010069:Oxadiazoles; D013558:Sydnones; C009257:sidnocarb
Vliianie sidnokarba na gemodinamiku i pereraspredelenie krovi pri funktsional'nykh probakh posle 6-chasovoĭ antiortostaticheskoĭ gipokinezii.