The effect of short- and long-term exercise on aldolase activity in muscles of CW-1 and C57/BL mice of various ages.
The effect of wheel running on the levels of fructose 1,6-bisphosphate aldolase A (EC 4.1.2.13) in striated muscles of young and old mice was compared. Short-term (6-10 weeks) and long-term (over 12 months) regimens were included in the study. The studies were conducted on the CW-1 outbred strain and on the C57/BL inbred strain of mice. It was shown that, in the short-term regimens, old animals of both strains showed either no increase (C57/BL) or a reduction (CW-1) in aldolase activity in hind leg muscles. On the other hand, young animals of both strains showed increases in aldolase activity of 10-20%. In the long-term regimen young and intermediate age animals showed 30-100% increases in aldolase activity in hind leg muscles over control sedentary animals. This adaptive capacity to exercise was not observed in old animals. However, long-term exercise regimen prevented the age-associated decline in aldolase activity found in sedentary animals.
D000375:Aging; D000818:Animals; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009132:Muscles / Q000201:enzymology*; D005082:Physical Exertion; D013997:Time Factors
D005634:Fructose-Bisphosphate Aldolase