title: Pharmacokinetic aspects of carbamazepine and its two major metabolites in plasma during overdosage.
abstract: In 10 out of 25 patients admitted with carbamazepine overdosage to local teaching hospitals sufficient plasma level data of carbamazepine and two of its main metabolites (epoxide and dihydroxy) were obtained to characterize their terminal elimination kinetics. Some other pharmacokinetic aspects which could be useful in extrapolating to the amount and time of ingestion of the overdose are discussed.
mesh_terms: D001711:Biotransformation; D002220:Carbamazepine / Q000031:analogs & derivatives / Q000097:blood / Q000506:poisoning*; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics
chemical_list: D002220:Carbamazepine; C004822:10,11-dihydro-10,11-dihydroxy-5H-dibenzazepine-5-carboxamide; C012227:carbamazepine epoxide