Effect of intra-individual change in serum protein binding on the pharmacologic response of R- and S-disopyramide in the rabbit.
The influence of altered serum protein binding on the pharmacologic response to R- and S-disopyramide was studied in the rabbit. Binding changes of disopyramide were achieved by the injection of human glycoprotein fraction VI. During constant infusion of R-disopyramide, the glycoprotein injection increased the total drug concentration in serum at steady state, while the unbound concentration was unaltered. The glycoprotein injection, however, decreased the unbound concentration and increased the total concentration during the steady-state infusion of S-disopyramide. In both experiments, the measured pharmacological response (delta QRS duration) reflected the change in the unbound drug concentration.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D004206:Disopyramide / Q000097:blood* / Q000494:pharmacology; D004562:Electrocardiography; D007700:Kinetics; D008297:Male; D011485:Protein Binding; D011817:Rabbits; D013237:Stereoisomerism
D001798:Blood Proteins; D004206:Disopyramide