Statistics of the mouse bone-marrow micronucleus test: counting, distribution and evaluation of results.
The distribution of historical control results from male mice tested in the bone-marrow micronucleus test was used to optimize counting procedures and to develop decision rules for evaluating test results. The ratio of normochromatic to polychromatic erythrocytes followed a normal distribution, while the incidence of micronucleated polychromatic and normochromatic erythrocytes followed a binomial distribution. Recommendations for the number of cells to be scored per animal and for the evaluation of results are based on these distributions and the two-hypothesis multiple-decision approach of Selby and Olsen (1981).
D000818:Animals; D001853:Bone Marrow / Q000502:physiology*; D002467:Cell Nucleus / Q000502:physiology*; D002478:Cells, Cultured; D004912:Erythrocytes / Q000502:physiology*; D007700:Kinetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens / Q000633:toxicity; D009154:Mutation; D013223:Statistics as Topic
D009153:Mutagens