title: Humoral immune responses in murine pregnancy. III. Relationship between anti-paternal alloantibody levels in maternal serum, placenta and fetus.
abstract: Studies have been carried out on allogeneically mated pregnant female mice to examine the relationship between the levels of anti-paternal alloantibody occurring free or as soluble immune complexes in the maternal peripheral circulation and that existing in a bound form in the placenta and free in the fetal circulation. In a 'non-responder' strain of mouse, as defined by the inability to detect anti-paternal alloantibody in the peripheral serum of multiparous allogeneically mated females, no alloantibody could be detected as soluble immune complexes, bound to the placenta or in the fetal circulation. A similar situation existed in females of a 'responder' strain during their first pregnancy and in some individuals during their second. However, in 'responder' strain females possessing alloantibody in their peripheral serum, alloantibody could be eluted from the semi-allogeneic placenta when peripheral titres exceeded 1:16, and was found in the fetal serum when they exceeded 1:128. When such females were subsequently mated syngeneically, alloantibody was detected in placental eluates only when peripheral titres exceeded 1:128-256 and in the fetal serum when they exceeded 1:16. The alloantibody eluted from placentae and that found in neonatal serum exhibited similar isotype distribution to that in the peripheral serum. These results are discussed with reference to the relative importance of the yolk sac and the immunoabsorbent semi-allogeneic placenta in the restricted transfer of pregnancy-induced anti-paternal alloantibody to the fetus.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D000936:Antigen-Antibody Complex; D005260:Female; D005333:Fetus / Q000276:immunology*; D007518:Isoantibodies / Q000032:analysis*; D008431:Maternal-Fetal Exchange; D051379:Mice; D010298:Parity; D010920:Placenta / Q000276:immunology*; D011247:Pregnancy; D011270:Pregnancy, Animal
chemical_list: D000936:Antigen-Antibody Complex; D007518:Isoantibodies