title: Effect of partially purified B- and T-lymphocyte inhibitory factors on the mitogenic and chemotactic responses.
abstract: Avian lymphocyte inhibitory factor (LyIF) is produced by thymic (T) and bursal (B) lymphocytes following sensitization of chicks to Mycobacterium tuberculosis. Our previous studies showed that maximum activities for both B- and T-LyIF were within a molecular weight range of 10,000 to 50,000 daltons (LyIF-III). These results led us to question what other functional differences may exist. The chemotactic and mitogenic properties of B- and T-LyIF-III were investigated. Neither B- nor T-LyIF-III had chemotactic properties whereas both lymphokines significantly inhibited the uptake of [3H]-thymidine in the presence of phytohemagglutinin-M. Inhibition of migration by LyIF-III may be a reflection of LyIF-III inhibition of deoxyribonucleic acid synthesis.
mesh_terms: D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D002645:Chickens / Q000097:blood; D005260:Female; D007962:Leukocytes / Q000187:drug effects*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008222:Lymphokines / Q000494:pharmacology*; D008297:Male
chemical_list: D008222:Lymphokines