The importance of the subendothelial connective tissue to the permeability of the neointimal barrier.
The thoracic aortas from two rabbits that had survived a single embolectomy catheter lesion for 2 years were studied by transmission electron microscopy after vital staining with Evans blue. An intimal thickening was formed inside the original internal elastic lamella in the re-endothelialized areas. Small blue areas in the ventral aortic wall showed intact endothelial cells covering an amorphous structureless subendothelial matrix. These observations indicate that endothelial cells do not form an effective barrier in the absence of differentiated subendothelial connective tissue.
D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism / Q000648:ultrastructure*; D002199:Capillary Permeability; D003238:Connective Tissue / Q000378:metabolism / Q000648:ultrastructure; D004727:Endothelium / Q000378:metabolism / Q000648:ultrastructure; D005070:Evans Blue; D008297:Male; D008854:Microscopy, Electron; D011817:Rabbits
D005070:Evans Blue