Biochemical studies on a lysosomal storage disease in Abyssinian cats.
Blood lipid analysis was performed on the serum of 2 normal kittens and 1 adult cat and on serum from 3 affected kittens. Thin layer chromatography was done on tissue extracts of various organs from clinically affected kittens and unaffected unrelated kittens of a similar age, and on serum from carrier cats, affected kittens, related unaffected kittens and unrelated kittens. Spleen and lymph node cell cultures were prepared from 1 affected kitten and the growth medium and cell cultures were analysed for lipids. A lecithin-like phospholipid was identified in the serum of an affected kitten, a carrier cat and a related unaffected kitten. This substance was produced by the liver of affected kittens and also by macrophage-like cells in spleen cell cultures prepared from the spleen of a kitten with signs of the disease.
D000818:Animals; D001923:Brain Chemistry; D002371:Cat Diseases / Q000378:metabolism*; D002415:Cats; D002478:Cells, Cultured; D002855:Chromatography, Thin Layer; D007668:Kidney / Q000032:analysis; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000032:analysis; D008168:Lung / Q000032:analysis; D008198:Lymph Nodes / Q000032:analysis; D008661:Metabolism, Inborn Errors / Q000378:metabolism / Q000662:veterinary*; D010743:Phospholipids / Q000032:analysis; D013154:Spleen / Q000032:analysis
D008055:Lipids; D010743:Phospholipids