title: Forebrain damage in chick embryos exposed to carbon monoxide.
abstract: The consequences of CO-induced hypoxia to the forebrain of seven-day-old chick embryos were investigated. Exposure of embryos to CO for three hours caused hemorrhages in developing forebrain areas. Carboxyhemoglobin levels reached about 50% in the embryos. Two weeks later, about one day prior to hatching, morphology of large neurons in the paleostriatum primitivum was evaluated. In Golgi-stained sections examined under the light microscope, the CO-exposed chicks were found to have reduced branching of the dendritic tree. In addition, the nuclear size of the paleostriatum primitivum neurons was reduced in the CO-exposed chicks. These findings in chick embryos are comparable to results in previous experiments with fetal rats.
mesh_terms: D000818:Animals; D001921:Brain / Q000002:abnormalities* / Q000187:drug effects / Q000196:embryology; D002248:Carbon Monoxide / Q000633:toxicity*; D002263:Carboxyhemoglobin / Q000378:metabolism; D002490:Central Nervous System / Q000502:physiology; D002642:Chick Embryo; D000860:Hypoxia / Q000503:physiopathology; D009043:Motor Activity / Q000187:drug effects; D013723:Teratogens
chemical_list: D013723:Teratogens; D002248:Carbon Monoxide; D002263:Carboxyhemoglobin