Structural studies on pyrrolomycins C, D and E.
Pyrrolomycins C, D and E are new members of the pyrrolomycin group of antibiotics produced by an Actinosporangium sp. The structures of pyrrolomycins C and D were determined to be 2,3-dichloro-5-(3',5'-dichloro-2'-hydroxybenzoyl)pyrrole and 2,3,4-trichloro-5-(3',5'-dichloro-2'-hydroxybenzoyl)pyrrole, respectively, by means of spectroscopic and synthetic approaches while that of pyrrolomycin E was shown to be 5-chloro-2-(3',5'-dichloro-2'-hydroxyphenyl)-3-nitropyrrole by spectroscopic data.
D000900:Anti-Bacterial Agents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011758:Pyrroles; D013306:Streptomycetaceae / Q000254:growth & development; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D011758:Pyrroles; C034690:pyrrolomycin C; C034691:pyrrolomycin D; C039863:pyrrolomycin E