Pathological changes produced by exposure of rabbits and rats to smokes from mixtures of hexachloroethane and zinc oxide.
Rabbits and rats were exposed to single doses of hexachloroethane zinc smoke and observed for up to 14 days. Changes in the respiratory tract included acute inflammation and in some cases necrosis of the laryngeal and tracheal mucosa. Pulmonary oedema and pneumonitis were observed in decedent animals. Animals that survived to the end of the experiment, showed similar but much less florid changes in the respiratory tract.
D000818:Animals; D001273:Atmosphere Exposure Chambers; D004338:Drug Combinations; D004980:Ethane / Q000031:analogs & derivatives*; D005260:Female; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D008297:Male; D011817:Rabbits; D011897:Random Allocation; D051381:Rats; D012140:Respiratory Tract Diseases / Q000139:chemically induced* / Q000473:pathology; D012906:Smoke / Q000009:adverse effects; D015032:Zinc / Q000633:toxicity*; D015034:Zinc Oxide / Q000633:toxicity*
D004338:Drug Combinations; D006843:Hydrocarbons, Chlorinated; D012906:Smoke; C010182:hexachloroethane; D015032:Zinc; D004980:Ethane; D015034:Zinc Oxide