title: Testosterone metabolism in discrete areas of the hypothalamus and adjacent brain regions of male and female Japanese quail (Coturnix coturnix Japonica).
abstract: The metabolism of testosterone in small regions of the hypothalamus was studied by an in vitro radioenzymatic assay in male and female Japanese quail. 5 beta-reduction was the most important metabolic pathway. This enzymatic activity is not evenly distributed in the brain: it shows a rostral to caudal decrease. There is some suggestion that 5 beta-reduction could be more active in females than in males which could contribute to the behavioral dimorphism in this species.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D003370:Coturnix / Q000378:metabolism*; D005260:Female; D007031:Hypothalamus / Q000201:enzymology / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism; D011784:Quail / Q000378:metabolism*; D012737:Sex Factors; D013739:Testosterone / Q000378:metabolism*
chemical_list: D013739:Testosterone; D010088:Oxidoreductases; C021936:3-oxo-5 beta-steroid delta 4-dehydrogenase