[Treatment of pain caused by metastases of reactivated prostatic cancer with ifosfamide].
Ifosfamide (Z 4942) is an alkylating agent with the structure of a cyclophosphamide analog. Preliminary studies performed in our hospitals demonstrate the releasing effect of Ifosfamide for persistent pain caused by metastases of the prostatic cancer at various regions. Ifosfamide was given 2 grams a day intravenously with hydration and alkalization for consecutive 5 days. The regimen was performed every 3 or 4 weeks. Pain has disappeared in 7 of 10 cases within 2 or 3 courses. Pain of other 3 cases has also greatly reduced. The effective rate for the primary lesion of the prostatic carcinoma in stage C and D is 30.7%. Side effects were nausea, vomiting, hair loss and leukopenia.
D000368:Aged; D003520:Cyclophosphamide / Q000031:analogs & derivatives*; D006801:Humans; D007069:Ifosfamide / Q000627:therapeutic use*; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010148:Intractable Pain / Q000188:drug therapy*; D011471:Prostatic Neoplasms / Q000473:pathology / Q000503:physiopathology*
D003520:Cyclophosphamide; D007069:Ifosfamide