The effect of low density polyethylene containers on some hospital-manufactured eyedrop formulations. II. Inhibition of the sorption of phenylmercuric acetate.
The presence of phosphate ions in solutions of phenylmercuric acetate inhibits the sorption of the preservative by low-density polyethylene eyedrop bottles. The extent to which sorption is inhibited depends upon the concentration of phosphate but does not appear to be temperature dependent. Phenylmercuric preservatives react with chloride ion to produce insoluble phenylmercuric chloride and should therefore not be used to preserve eyedrops containing chloride or hydrochloride salts.
D000327:Adsorption; D002021:Buffers; D002626:Chemistry, Pharmaceutical; D002712:Chlorides; D004349:Drug Packaging; D009883:Ophthalmic Solutions / Q000032:analysis*; D010662:Phenylmercuric Acetate / Q000032:analysis*; D010663:Phenylmercury Compounds / Q000032:analysis*; D010710:Phosphates; D011095:Polyethylenes; D011310:Preservatives, Pharmaceutical; D013997:Time Factors
D002021:Buffers; D002712:Chlorides; D009883:Ophthalmic Solutions; D010663:Phenylmercury Compounds; D010710:Phosphates; D011095:Polyethylenes; D011310:Preservatives, Pharmaceutical; D010662:Phenylmercuric Acetate