[Effect of clofelin and apressin on the autoregulation of cerebral blood flow].
Acute experiments on cats under mild sodium ethaminal anesthesia and local novocaine anesthesia were made to determine the autoregulative reactions (AR) of the cerebral vessels to different levels of arterial pressure (AP). After clofelin administration the autoregulation borders shifted to the right i. e. towards higher AP levels. Unlike clofelin, apressin made the AP borders shift to the left, i. e. towards lower AP levels. Possible mechanisms of the effects seen and their importance for medicine are discussed.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003000:Clonidine / Q000494:pharmacology*; D005260:Female; D006706:Homeostasis / Q000187:drug effects*; D006830:Hydralazine / Q000494:pharmacology*; D008297:Male; D014655:Vascular Resistance / Q000187:drug effects
D000959:Antihypertensive Agents; D006830:Hydralazine; D003000:Clonidine
Vliianie klofelina i apressina na autoreguliatsiia mozgovogo krovotoka.