title: Pathogenesis of Legg-Calvé-Perthes disease.
abstract: After reviewing the most widely accredited theories on pathogenesis advanced up to now, the authors report the results of a histological histochemical and ultrastructural study of the upper femoral epiphysis in Legg-Calvé-Perthes disease. They conclude that the primary lesion is probably a dysplastic change in the epiphyseal cartilage.
mesh_terms: D002648:Child; D004838:Epiphyses / Q000378:metabolism / Q000648:ultrastructure; D005270:Femur Head / Q000378:metabolism / Q000648:ultrastructure*; D005271:Femur Head Necrosis / Q000473:pathology*; D006132:Growth Plate / Q000378:metabolism / Q000648:ultrastructure; D006801:Humans; D007873:Legg-Calve-Perthes Disease / Q000378:metabolism / Q000473:pathology*