title: Cardiac and renal responses to cross-clamping of the descending thoracic aorta.
abstract: The present study was performed to document the relative efficacy of commonly applied techniques used adjunctively during 1 hour of descending thoracic aortic cross-clamping. Renal and cardiac responses were determined by standard laboratory methods. There were four experimental groups: (1) heparin-bonded shunt; (2) partial femoral-femoral bypass; (3) sodium nitroprusside; (4) control. Each of the experimental groups showed abnormal hemodynamic responses during cross-clamping. Elevations in left ventricular end-diastolic pressure (LVEDP) and systolic blood pressure were common events during clamping, and cardiac output often decreased. Nevertheless, left ventricular performance curves after cross-clamping showed similar increases in left ventricular stroke work (LVSW) with increasing preload. In addition, left ventricular biopsy specimens showed preservation of myocardial high-energy phosphate stores and essentially normal ultrastructural integrity. Radioactive microspheres generally showed increased myocardial blood flow during and after cross-clamping, but no evidence of preferential subendocardial ischemia. Examination of renal function showed a marked decrease in urine output, glomerular filtration rate, and renal plasma flow during cross-clamping. Following the release of the cross-clamp, renal function returned to 50% to 85% of baseline status. Since we could find no major advantage of any of the techniques employed under the present experimental conditions, we suggest that all of the techniques should be part of the surgical armamentarium and the particular preoperative and/or intraoperative findings in a specific case should determine which technique is most appropriate for a given patient.
mesh_terms: D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D001013:Aorta, Thoracic / Q000648:ultrastructure; D001018:Aortic Diseases / Q000503:physiopathology / Q000601:surgery*; D001783:Blood Flow Velocity; D003250:Constriction; D004285:Dogs; D005260:Female; D006439:Hemodynamics; D007677:Kidney Function Tests; D008297:Male; D010725:Phosphocreatine / Q000032:analysis; D012079:Renal Circulation
chemical_list: D010725:Phosphocreatine; D000255:Adenosine Triphosphate