Copper storage disease with intravascular haemolysis in a Bedlington terrier.
A 5-year-old male Bedlington terrier was found to have haemoglobinuria from intravascular haemolysis. The owners reported also recent vomiting, occasional diarrhoea, reduced activity and increased drinking and urination. A diagnosis of inherited copper storage disease, as previously described in this breed, was established by demonstrating characteristic light and electron microscopic changes and copper content of 7, 717 micrograms/g in biopsied liver. Treatment by chelation with d-penicillamine and a low copper diet was instituted and the dog remains well 10 months later. Intravascular haemolysis is rare in dogs and an uncommon finding in Bedlington terriers with copper storage disease.
D000818:Animals; D003300:Copper / Q000378:metabolism*; D004283:Dog Diseases / Q000378:metabolism* / Q000628:therapy; D004285:Dogs; D006461:Hemolysis; D008107:Liver Diseases / Q000378:metabolism / Q000628:therapy / Q000662:veterinary*; D008297:Male
D003300:Copper