title: High-effective aluminium free phosphate binder. In vitro and in vivo studies.
abstract: For the purpose of intestinal phosphate binding we have developed aluminium free natural polymers consisting of heteropolyuronic acid charged with different cations. The in vitro experiments showed an efficacy two to three times greater than Aludrox. During up to six months of clinical application no serious side effects have been detected, constipation ceased and serum phosphate was maintained in an acceptable range.
mesh_terms: D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D010710:Phosphates / Q000097:blood*; D011108:Polymers / Q000627:therapeutic use*; D006435:Renal Dialysis; D014574:Uronic Acids / Q000627:therapeutic use*
chemical_list: D010710:Phosphates; D011108:Polymers; D014574:Uronic Acids