Probable mechanism of action of methyldopa on cholinergically innervated tissues.
Methyldopa (200 and 400 micrograms/ml) induced an increase in the responsiveness of guinea-pig ileum to ACh after incubation for 1 hr 15 min. However, no such effect was observed in the case of frog rectus abdominis muscle. It is suggested that methyldopa influences receptor mechanisms associated with cholinergic muscarinic but not nicotinic receptors.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D002799:Cholinergic Fibers / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D008750:Methyldopa / Q000494:pharmacology*; D009132:Muscles / Q000187:drug effects; D011898:Ranidae; D011950:Receptors, Cholinergic / Q000187:drug effects*; D014649:Vas Deferens / Q000187:drug effects
D011950:Receptors, Cholinergic; D008750:Methyldopa; D000109:Acetylcholine