Unilateral injection of GABA agonists in the superior colliculus: asymmetry to tactile stimulation.
A unilateral microinjection of each one of three different GABA agonists (Muscimol: 1.4 nmoles; Baclofen: 0.8 nmole; THIP: 10.7 nmoles) into the superior colliculus was found to result in a reversible asymmetry in the rat's responsiveness to tactile stimulation. The rat was hyporeactive to stimulations applied contralaterally and hyperreactive to stimulations applied ipsilaterally to the infusion site. Furthermore, the rat showed ipsiversive turning in response to tactile stimulation applied either ipsi- or contralaterally to the infusion site. The results are discussed in relation with motor and sensory asymmetry produced by unilateral manipulations affecting the striato-nigro tectal system.
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D007839:Functional Laterality; D007555:Isoxazoles / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D009118:Muscimol / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D010812:Physical Stimulation; D051381:Rats; D011919:Rats, Inbred Strains; D013477:Superior Colliculi / Q000187:drug effects / Q000502:physiology*; D014110:Touch / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D000700:Analgesics; D007555:Isoxazoles; D010080:Oxazoles; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D001418:Baclofen; C015542:gaboxadol