title: Rhythms of barbiturate-induced sleep time in deermice entrained to non-twenty-four hour photocycles.
abstract: The present experiment examined whether entrainment to twenty-four hour days is advantageous for physiological and behavioral adaptations to a pharmacological challenge. Adult, male deermice (Peromyscus maniculatus) were injected with sodium pentobarbital at 8.5, 14.5, 20.5, 2.5 and again at 8.5 hr after light onset while entrained to a 24 hr day (light/dark (LD) 14:10). Time to recover from anesthesia was recorded. Subsequently, the dark phase of the LD cycle was reduced 15-20 min every 10 days until a 23 hr photocycle was achieved, (LD 14:9; T = 23 hr). Injections of sodium pentobarbital were again administered at 8.5, 14.5, 20.5 and 2.5 hr after light onset and sleep times recorded. This procedure was repeated at T = 21 hr (LD 14:7) and T = 18 hr (LD 14:4). A variation in sleep time was observed during entrainment to all T-cycles except T = 18 hr. Sleep time after drug administration was generally longer during the light than during the dark phase of each photocycle. Recovery from anesthesia was not compromised in mice entrained to photocycles with periods of 23 or 21 hr; however, entrainment to very short days disrupted the normal pattern of response to barbiturate administration. Entrainment to a range of daylengths that deviate appreciably from 24 hr is consistent with normal physiological function.
mesh_terms: D000818:Animals; D008027:Light; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D010507:Periodicity; D010542:Peromyscus; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors
chemical_list: D010424:Pentobarbital