Membrane potential fluctuations associated with glutamate- and homocysteate-induced depolarizations in hippocampal neurons.
Depolarizations induced by L-glutamate (Glu) or D-homocysteate (DH) in CA3 neurons were accompanied by increases in membrane potential fluctuation in thin hippocampal sections of the guinea pig. The properties of the Glu- and DH-induced noises suggest that they were induced by gating actions of amino acids on the ionic channels, and that an average open-gate time for DH is shorter than that for Glu.
D000818:Animals; D004560:Electricity; D005971:Glutamates / Q000494:pharmacology*; D006168:Guinea Pigs; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects*; D006710:Homocysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007478:Iontophoresis; D008345:Manganese / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D013779:Tetrodotoxin / Q000494:pharmacology
D005971:Glutamates; D006710:Homocysteine; C007956:homocysteic acid; D008345:Manganese; D013779:Tetrodotoxin