Tolerance and cross-tolerance to morphine and ethanol in mice selectively bred for differential sensitivity to ethanol.
Ethanol-sensitive long-sleep mice showed greater sensitivity to ethanol-induced hypothermia whereas the less sensitive short-sleep mice showed greater sensitivity to morphine-induced hypothermia. The short-sleep mice, but not the long-sleep mice, displayed a degree of cross-tolerance to the hypothermic effects of ethanol following repeated exposure to morphine.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology*; D005838:Genotype; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000494:pharmacology*; D012641:Selection, Genetic; D012894:Sleep Stages / Q000187:drug effects
D000431:Ethanol; D009020:Morphine