Experimental sensitization of guinea pigs by drugs. Comparison of the maximization test with the wholly intradermal test.
The capacity of tegobetain, pyrrolnitrin, tolcyclate and chlorquinaldol to induce delayed-type contact sensitization was studied in guinea pigs in 2 series of tests using the method of Magnusson & Kligman and the authors' modification of the wholly intradermal Draize technique. Histological examination of skin biopsies obtained from the test area demonstrated that tegobetain, pyrrolnitrin and tolcyclate are potential sensitizers.
D000818:Animals; D000935:Antifungal Agents / Q000633:toxicity; D001622:Betaine / Q000031:analogs & derivatives / Q000633:toxicity; D001706:Biopsy; D002750:Chlorquinaldol / Q000633:toxicity; D003877:Dermatitis, Contact / Q000175:diagnosis* / Q000209:etiology; D005260:Female; D006168:Guinea Pigs; D007428:Intradermal Tests; D008297:Male; D011764:Pyrrolnitrin / Q000633:toxicity; D012867:Skin / Q000473:pathology; D012882:Skin Tests; D013859:Thiocarbamates / Q000633:toxicity
D000935:Antifungal Agents; D013859:Thiocarbamates; D001622:Betaine; C065099:Tego-Betain; D002750:Chlorquinaldol; D011764:Pyrrolnitrin; C013305:tolciclate