title: The dermatitis-producing constituents of Euphorbia hermentiana latex.
abstract: Five ingenane derivatives, 3-O-n-(deca-2,4,6-trienoyl)-16-O-[(Z)-2-methyl-2-butenoyl]-16-hydroxyingenol (1), 3-O-[(Z)-2-methyl-2-butenoyl]-5,16,20-O-triacetyl-16-hydroxyingenol (2), 3-O-[(Z)-2-methyl-2-butenoyl]-16,20-O-diacetyl-16-hydroxyingenol (3), 3-O-[(Z)-2-methyl-2-butenoyl]-20-O-acetylingenol (4), and 3-O-[(Z)-2-methyl-2-butenoyl]-16-O-acetyl-20-deoxy-16-hydroxyingenol (5) were isolated with a new procedure that uses droplet counter-current chromatography, from a dermatitis-producing fraction of the latex of Euphorbia hermentiana Lem. The structures of the new compounds 2,3, and 5 were established by the interpretation of their spectroscopic data and those of their hydrolytic and acetylated derivatives.
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003877:Dermatitis, Contact / Q000209:etiology*; D004224:Diterpenes / Q000032:analysis; D006801:Humans; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D051379:Mice; D010947:Plants, Toxic / Q000032:analysis*
chemical_list: D004224:Diterpenes