[Semisynthetic penicillins and cephalosporins inhibit in vitro myelopoiesis in a dose-dependent manner].
Penicillin-G degradation products have been shown to inhibit in vitro myelopoiesis in a dose-dependent manner. Similar inhibition was seen with 6 semisynthetic penicillins and 2 cephalosporins. 50% inhibitory doses in vitro well matched total and daily doses given in vivo before neutropenia developed. These findings suggest a toxic rather than an immune-mediated pathogenesis for betalactam-induced neutropenia.
D001854:Bone Marrow Cells; D002511:Cephalosporins / Q000494:pharmacology*; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D009503:Neutropenia / Q000139:chemically induced; D010400:Penicillin G / Q000494:pharmacology*
D002511:Cephalosporins; D010400:Penicillin G
Semisynthetische Penicilline und Cephalosporine hemmen die In-vitro-Myelopoiese dosisabhängig.