Arginine biosynthesis in Legionella pneumophila: absence of N-acetylglutamate synthetase.
Legionella pneumophila was unable to grow in a chemically defined medium without arginine because it could not carry out the first step in the biosynthetic pathway, the conversion of glutamate to N-acetylglutamate. All strains examined could grow when N-acetylglutamate (or other later arginine precursors) were substituted for arginine. No activity corresponding to N-acetylglutamate synthetase could be detected in cell extracts of L. pneumophila.
D000123:Acetyltransferases / Q000032:analysis*; D051046:Amino-Acid N-Acetyltransferase; D001120:Arginine / Q000031:analogs & derivatives / Q000096:biosynthesis* / Q000494:pharmacology; D007700:Kinetics; D007875:Legionella / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D012703:Serotyping; D013045:Species Specificity
D001120:Arginine; D000123:Acetyltransferases; D051046:Amino-Acid N-Acetyltransferase