title: The acute toxicity of penta-, hexa-, and heptachlorohydroxydiphenyl ethers in mice.
abstract: The acute intraperitoneal LD50 values of various hydroxychlorodiphenyl ethers (HO-ClX-DPEs; X = 5-7) in mice have been determined. The acute toxicities observed were on the order of, or slightly less than, that observed previously for 2-hydroxy-2',4,4'-trichlorodiphenyl ether (2-HO-Cl3-DPE; Irgasan DP-300; Triclosan), a commonly used bactericide. However, the acute toxicities determined for these compounds were substantially less than have been observed for HO-Cl9-DPEs and pentachlorophenol. The HO-ClX-DPEs had a marked hypothermic effect, similar to that produced by 2-HO-Cl3-DPE. Symptomatology following exposure to the HO-ClX-DPEs (X = 5-7) suggested a nonspecific depressant effect on the central nervous system.
mesh_terms: D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D005260:Female; D055768:Halogenated Diphenyl Ethers; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D007928:Lethal Dose 50; D051379:Mice; D010647:Phenyl Ethers / Q000633:toxicity; D013997:Time Factors
chemical_list: D055768:Halogenated Diphenyl Ethers; D006843:Hydrocarbons, Chlorinated; D010647:Phenyl Ethers; C012480:predioxin; C040197:2-hydroxy-2',3',4,5,5',6'-hexachlorodiphenyl ether; C040198:2-hydroxy-2',3',4,4',5,5',6'-heptachlorodiphenyl ether