Soft-tissue injury caused by antineoplastic drugs is inhibited by topical dimethyl sulphoxide and alpha tocopherol.
D000287:Administration, Topical; D000818:Animals; D003240:Connective Tissue Diseases / Q000139:chemically induced* / Q000473:pathology; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage / Q000627:therapeutic use*; D004317:Doxorubicin / Q000633:toxicity*; D004359:Drug Therapy, Combination; D006168:Guinea Pigs; D009336:Necrosis; D012867:Skin / Q000187:drug effects; D024505:Tocopherols; D014810:Vitamin E / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use
D014810:Vitamin E; D004317:Doxorubicin; D024505:Tocopherols; D004121:Dimethyl Sulfoxide