[Comparative study on the effect of the dopamine receptor blockers metoclopramide and domperidone on stomach emptying and the visualization of the small intestine in monocontrast].
The effects of a new dopamine receptor blocking agent, domperidone are compared pharmacoradiographically with the well-know action of metoclopramide. The investigated parameters were pyloric muscle function, passage time through the small intestine and, in correction with this, an evaluation of barium filling of the small intestine. Our investigations show that domperidone at dosages of 0.1 mg/kg and 0.2 mg/kg body weight does not accelerate intestinal junction as markedly as 0.3 mg/kg metoclopramide. Nevertheless, domperidone is as well suited as metoclopramide for pharmacoradiography of gastric emptying and for radiological examination of the small intestine. Hence, it can be concluded that the stimulation of the pyloric muscle as the leading pace maker of propulsion is achieved satisfactorily. Contrary to the findings with metoclopramide, domperidone shows no central nervous side effects. It appears that domperidone, at therapeutic dosages, does not pass the blood-brain barrier. Hence, this pharmaceutical preparation should prove of particular value in paediatrics.
D000328:Adult; D000368:Aged; D004294:Domperidone / Q000494:pharmacology*; D018492:Dopamine Antagonists; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007421:Intestine, Small / Q000000981:diagnostic imaging; D008297:Male; D008787:Metoclopramide / Q000494:pharmacology*; D008875:Middle Aged; D010528:Peristalsis / Q000187:drug effects*; D011859:Radiography
D018492:Dopamine Antagonists; D004294:Domperidone; D008787:Metoclopramide
Vergleichende Untersuchungen der Wirkung der Dopaminrezeptoren-Blocker "Metoclopramid" und "Domperidon" auf die Magenentleerung und die Darstellung des Dünndarmes in Monokontrast.