Decreased serum 19-nor-deoxycorticosterone (21-hydroxy-19-nor-4-pregnene-3, 20-dione) level in adrenal regeneration hypertensive rats.
An enzyme immunoassay of 19-nor-deoxycorticosterone in rat serum was established. The normal value of 19-nor-DOC in rat serum obtained from 9:00 am to 10:00 am was 148 +/- 30 ng/dl (mean +/- SE,n = 10). Serum levels of this steroid decreased in rats with adrenal regeneration hypertension during the course of the experiment up to 8 weeks, while systolic blood pressure rose progressively. We concluded that this mineralocorticoid is not involved at least as a circulating hormone in the pathogenesis of adrenal regeneration hypertension in rats.
D000311:Adrenal Glands / Q000503:physiopathology*; D000818:Animals; D001794:Blood Pressure; D003900:Desoxycorticosterone / Q000031:analogs & derivatives* / Q000097:blood; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012038:Regeneration; D013997:Time Factors
D003900:Desoxycorticosterone; C019026:19-nordeoxycorticosterone