[Natriuretic effect of haloperidol in dogs].
A 0.5 microM/kg/min infusion of haloperidol in the renal artery of 20 sodium-loaded dogs undergoing water diuresis is showed to induce the following net effects: a statistically significant reduction of both clearance of PAH (-18.1 +/- 6.6 ml/min), and glomerular filtration rate (-4.3 +/- 1.5 ml/min), an increase of both fractional excretion of sodium (+ 6.8 +/- 1.1%) and potassium (+ 55.1 +/- 5.5%), a decrease of fractional excretion of phosphate (-5.3 +/- 1.5%), and a lack of change of free water clearance (infused minus controlateral kidney difference).
D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006220:Haloperidol / Q000494:pharmacology*; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D010710:Phosphates / Q000652:urine; D011188:Potassium / Q000652:urine; D010130:p-Aminohippuric Acid / Q000652:urine
D010710:Phosphates; D000628:Aminophylline; D006220:Haloperidol; D011188:Potassium; D010130:p-Aminohippuric Acid
Effet natriurétique de l'halopéridol chez le chien.