title: The use of intrapartum fetal blood lactate measurements for the early diagnosis of fetal distress.
abstract: Lactate concentrations were measured during labor and at delivery in blood samples from the fetal presenting part and from the umbilical cord with the use of a rapid electrochemical technique. The value of these measurements to discriminate between normal and distressed fetuses was compared to that of pH, base excess, PCO2 and PO2 measurements in the same blood samples. The fetuses were divided into three groups, normal, prepathologic, and pathologic, according to the presence and severity of fetal distress as evaluated by Apgar score, intrapartum cardiotocography, meconium staining of the amniotic fluid, and cord arterial pH at birth. Lactate and pH provided the best parameters to distinguish between groups, with lactate having the most discriminating power at least in early labor and midlabor. The prospective value of discriminant functions derived from lactate and pH data was good when the fetuses were allocated into the normal group but poor when an attempt was made to allocate the fetuses into prepathologic and pathologic groups, with a high false negative rate. However, the discriminating ability was improved when prepathologic and pathologic fetuses were included into one single abnormal group. These results confirm the potential use of rapid fetal blood lactate measurements for the early diagnosis of intrapartum fetal distress.
mesh_terms: D000136:Acid-Base Equilibrium; D000328:Adult; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D005316:Fetal Distress / Q000175:diagnosis*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007743:Labor, Obstetric; D007773:Lactates / Q000032:analysis*; D010100:Oxygen / Q000502:physiology; D011247:Pregnancy; D011296:Prenatal Diagnosis / Q000379:methods*
chemical_list: D007773:Lactates; D010100:Oxygen