[Effect of prodigiosin and its combination with immunodepressants on the graft versus host reaction in mice].
The local (lymph node) graft-versus-host reaction (GVHR) in F1 (CBA X C57BL/6) mice and the lethal GVHR in C57BL/6 mice were induced by transfer of lymph node cells of CBA mice with skin allotransplants from C57BL/6 mice. Prednisolone in combination with asathioprin (imuran) administered to CBA mice inhibited the GVHR. Prodigiosan used alone was not active, while in combination with immunodepressants it increased their inhibitory effect. Adhesive cells with a suppressive activity were detected in the spleen of mice treated with prodigiosan. Such cells were capable of suppressing the capacity of syngeneic lymphocytes for inducing the GVHR.
D000818:Animals; D001379:Azathioprine / Q000008:administration & dosage / Q000494:pharmacology; D006087:Graft vs Host Reaction / Q000187:drug effects*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011239:Prednisolone / Q000008:administration & dosage / Q000494:pharmacology; D011353:Prodigiosin / Q000008:administration & dosage / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology
D007166:Immunosuppressive Agents; D011239:Prednisolone; D001379:Azathioprine; D011353:Prodigiosin
Vliianie prodigiozana i ego sochetaniia s immunodepressorami na reaktsiiu transplantat protiv khoziaina u mysheĭ.