title: Protein fluctuation and enzyme activity.
abstract: The possible participation of protein fluctuation in enzyme activity is considered in this paper. Fluctuation is defined as vibrations, involving collective motion of a large number of atoms in protein molecules. Kinetic and thermodynamic aspects of protein fluctuation and enzyme-ligand interactions are discussed, paying special attention to the influence of electric fields and environmental microviscosity. A brief analysis of available experimental and theoretical data strongly suggests an interrelationship between protein fluctuation and enzyme function.
mesh_terms: D004798:Enzymes / Q000378:metabolism*; D007700:Kinetics; D008024:Ligands; D008956:Models, Chemical; D011487:Protein Conformation; D013816:Thermodynamics
chemical_list: D004798:Enzymes; D008024:Ligands