[Decrease in the intensity of the EPR cytochrome P-450, adrenodoxine and free radical signals in the adrenal cortex of dogs under the effect of o,p-dichlorodiphenyldichloroethane].
A study was made of the action of the adrenocorticolytic drug chloditane (o.p'-DDD) on the content of cytochrome P-450 adrenodoxine and free radicals in the dog adrenal cortex. After a single feeding of 50 mg/kg bw o.p'-DDD EPR signals with xi-factors 2.25, 1.94 and 2.00 reduced 30-40%. Three-fold feeding of the drug in a dose of 100 mg/kg bw produced a further demonstrable decrease of signals. These changes attest to a possible inhibition of the hydroxylase complex in the adrenal cortex induced by o.p'-DDD.
D000302:Adrenal Cortex / Q000378:metabolism*; D000325:Adrenodoxin / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005609:Free Radicals; D008297:Male; D008939:Mitotane / Q000008:administration & dosage*
D065607:Cytochrome P-450 Enzyme Inhibitors; D005609:Free Radicals; D000325:Adrenodoxin; D008939:Mitotane; D003577:Cytochrome P-450 Enzyme System
Snizhenie intensivnosti signala EPR tsitokhroma P-450, adrenodoksina i svobodnykh radikalov pod vozdeĭstviem o,p-dikhlordifenildikhlorétana v kore nadpochechnykh zhelez sobak.