The effect of serum from multiple sclerosis patients in remission on the incubated rat brain slices.
Addition of human serum to incubated rat cerebral slices induced increased generation of myelin-related, membranous fragments floating on 0.32 M sucrose. Sera from 20 healthy subjects and 19 patients with various neurological disorders were equally active in this respect. On the other hand, the myelin-degrading activity of sera from 20 multiple sclerosis patients in remission was found to be significantly elevated by about 50%. The present findings support the contention that the serum of multiple sclerosis patients possesses increased potency to induce myelin sheath alterations.
D000293:Adolescent; D000328:Adult; D000818:Animals; D001921:Brain / Q000502:physiology*; D001923:Brain Chemistry; D006801:Humans; D066298:In Vitro Techniques; D008055:Lipids / Q000032:analysis; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood*; D009186:Myelin Sheath / Q000502:physiology; D051381:Rats
D008055:Lipids