Effect of morphine and leucine-enkephalin on the electrophysiological responses of Pacinian corpuscles of the cat.
The effects of morphine and Leu-enkephalin on the electrical activity of Pacinian corpuscles isolated from cat mesentery were studied. These drugs caused a short-term increase and subsequent decrease of the impulse activity, accompanied by a monotonic growth of the threshold for firing of action potentials and amplitudes of generator and action potentials. Naloxone induced an effect similar to that of morphine. The results obtained indicate that morphine and Leu-enkephalin evoke an increase in membrane potential of a nerve ending. These data may form the basis of the modulating effect of opioid peptides on encapsulated mechanoreceptor activity.
D000818:Animals; D002415:Cats; D004594:Electrophysiology; D004743:Enkephalin, Leucine / Q000494:pharmacology*; D008465:Mechanoreceptors / Q000187:drug effects*; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D010141:Pacinian Corpuscles / Q000187:drug effects*
D009270:Naloxone; D004743:Enkephalin, Leucine; D009020:Morphine