Partial ablation of the kidney by intraarterial ethanol in domestic swine.
Partial renal ablation was produced in 15/17 swine kidneys after segmental intraarterial injection of 1-2 ml of 95% ethanol. Complications were seen in 3 kidneys, including reflux of ethanol into nontarget vessels with subsequent total infarction of 2 kidneys, and the development of hydronephrosis in 1 kidney. Strictly selective catheterization and a very slow injection of ethanol are essential to avoid complications. This technique may find clinical application and the possible indications are discussed.
D000818:Animals; D002404:Catheterization; D004621:Embolization, Therapeutic / Q000379:methods*; D000431:Ethanol / Q000008:administration & dosage*; D007238:Infarction / Q000209:etiology / Q000473:pathology; D007269:Injections, Intra-Arterial; D007668:Kidney / Q000098:blood supply / Q000473:pathology; D011859:Radiography; D012077:Renal Artery / Q000000981:diagnostic imaging; D013552:Swine
D000431:Ethanol