Lectin (concanavalin A) binding to rat hepatocytes in different stages of cell differentiation.
A substantial part of hepatocytes originating from 19-day rat embryos are capable of binding concanavalin-A (Con-A) in the initial stage of culturing, and all embryonic hepatocytes acquire the binding property later on (until 24 days). Although the proportions of Con-A binding hepatocytes also are considerable in cultures derived from newborn and one-week old rats, they do not increase to 100% during culturing, and the cell of newborn rats show a marked decrease rather than increase in percentual Con-A binding capacity during the second part of the culturing period. The quantitative relations of Con-A binding sites were statistically identical in all age categories studied, and seem thus be independent of the age of the animal or culture.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D002454:Cell Differentiation; D002462:Cell Membrane / Q000276:immunology; D002478:Cells, Cultured; D003208:Concanavalin A / Q000378:metabolism*; D004622:Embryo, Mammalian; D005470:Fluorometry; D008099:Liver / Q000166:cytology*; D051381:Rats; D011919:Rats, Inbred Strains; D011952:Receptors, Concanavalin A / Q000378:metabolism*
D011952:Receptors, Concanavalin A; D003208:Concanavalin A