Influence of radiation dose patterns on lung tumor incidence in dogs that inhaled beta emitters: a preliminary report.
Different radiation dose patterns to the lung from inhaled beta-emitting radionuclides may influence the frequency and kind of biological effects. To determine the magnitude of this influence, groups of Beagle dogs were exposed to aerosols of 90Y, 91Y, 144Ce, or 90Sr in relatively insoluble particles and observed for their life spans. Different dose patterns were achieved by using these radionuclides having similar beta emissions and chemical form but having physical half-lives ranging from 2.6 days to 28 years. The range of initial lung burdens of radionuclides studied resulted in a range of biological effects from early deaths at the highest radiation doses to no discernible effects at the lowest doses. The effective half-lives of the four radionuclides in the lung ranged from 2.5 to 600 days. Within 1.5 years after exposure, some dogs died with radiation pneumonitis and pulmonary fibrosis. Between 1.5 and 10 years after exposure, 42 pulmonary carcinomas and 28 pulmonary sarcomas were observed in 163 dogs that died. Protracted irradiation of the lung from 90Sr or 144Ce resulted in a relatively high radiation dose and produced more total lung tumors but fewer lung tumors per rad than less protracted irradiation from 90Y or 91Y. At 10 years after inhalation exposure, the difference in risk per rad among the different dose patterns was a factor of 4 to 8, indicating that the different radiation dose patterns from inhaled beta emitters do influence lung tumor risk factors, at least at high (greater than 20,000 rad) doses to lung.
D000336:Aerosols; D000818:Animals; D002565:Cerium Radioisotopes / Q000009:adverse effects; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D004583:Electrons; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000209:etiology*; D012306:Risk; D013326:Strontium Radioisotopes / Q000009:adverse effects; D013997:Time Factors; D015021:Yttrium Radioisotopes / Q000009:adverse effects
D000336:Aerosols; D002565:Cerium Radioisotopes; D013326:Strontium Radioisotopes; D015021:Yttrium Radioisotopes