[Pathomorphology of endocrine glands during the latent period of experimental intestinal carcinogenesis].
Pathomorphology of endocrine glands in 62 rats in the latent period of intestinal carcinogenesis caused by 1,2-dimethyl hydrazine was studied. The morphological picture of the latent period includes atrophic changes of the adrenal cortex and the thyroid gland, A- and B-cells of pancreatic insulae and interstitial Leidig cells, as well as severer dystrophic changes of thyreotrophs, thymus epithelium, spermatogenic epithelium, and granuloses of growing follicles. These changes are combined with hypertrophy of follicle-stimulating gonadotrophs, hyperplasia of the body-tissue in the ovaries, as well as accumulation of neurosecretory substance in neurons of paraventricular and supraoptic nuclei of hypothalamus, neurosecretory pathways, and neurohypophysis. No morphological changes were found in the latent period in hypophysis acidophilic cells, lymphoid elements of the thymus, primordial follicles and cells of parathyroid glands.
D019813:1,2-Dimethylhydrazine; D000302:Adrenal Cortex / Q000473:pathology; D000818:Animals; D004127:Dimethylhydrazines; D004702:Endocrine Glands / Q000473:pathology*; D005260:Female; D007030:Hypothalamo-Hypophyseal System / Q000473:pathology; D007414:Intestinal Neoplasms / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D010053:Ovary / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology*; D051381:Rats; D013737:Testis / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology; D013961:Thyroid Gland / Q000473:pathology
D004127:Dimethylhydrazines; D019813:1,2-Dimethylhydrazine
Patomorfologiia éndokrinnykh zhelez v latentnom periode éksperimental'nogo kantserogeneza kishechnika.