[Spasmolytic activity of (3,4-dichloroanilino)phenylacetonitrile (H 74) and its analogs].
The influence of smooth muscle contractility of (3,4-dichloranilino)phenyl-acetonitrile (H 74) was studied in comparison with the analogs (4-chloranilino)phenyl-acetonitrile (H 47) and (3,4,5-trichloranilino)phenyl-acetonitrile (H 84) and several standard pharmaca. H 74 and H 84 showed a spasmolytic action that was almost equal to that of methphenethamine and papaverine. Other investigations have revealed that H 74 was free from any side effect. It is concluded that chloranilino-phenyl-acetonitriles cause a nonspecific inhibition of smooth muscle contractility.
D000097:Acetonitriles / Q000494:pharmacology*; D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D001464:Barium / Q000494:pharmacology; D017609:Barium Compounds; D002712:Chlorides; D004347:Drug Interactions; D005260:Female; D006168:Guinea Pigs; D006633:Histamine Antagonists; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology
D000097:Acetonitriles; D017609:Barium Compounds; D002712:Chlorides; D006633:Histamine Antagonists; D010276:Parasympatholytics; C024986:barium chloride; D000804:Angiotensin II; D001464:Barium; D012701:Serotonin; C039274:H 74; D000109:Acetylcholine
Spasmolytische Aktivität von (3,4-Dichloranilino)phenyl-acetonitril (H 74) und Analoga.