Influence of caffeine on arecoline-induced SCE in mouse bone-marrow cells in vivo.
The effect of exposure of mice for 5, 10 and 15 days to arecoline or/and caffeine on the frequency of sister-chromatid exchanges (SCEs) in bone-marrow cells was evaluated by using the fluorescence plus Giemsa technique. There was a significant increase in the frequency of SCEs after exposure to either arecoline or caffeine. When these two alkaloids were given in combination, the SCE frequency-enhancing effect was additive. The implications of coffee/tea drinking and betel chewing on oral cancer are discussed.
D000818:Animals; D001115:Arecoline / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects / Q000502:physiology*; D002110:Caffeine / Q000633:toxicity*; D003434:Crossing Over, Genetic / Q000187:drug effects*; D007700:Kinetics; D051379:Mice; D008815:Mice, Inbred Strains; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D002110:Caffeine; D001115:Arecoline