title: [Aryloxy- and arylthioalkylamine hypolipidemic agents].
abstract: Aryloxy and arylthioalkylamines related respectively to clofibrate and 2-(3,5-di-t-butyl-4-hydroxyphenylthio)hexanoic acid, a derivative of an active probucol metabolite, were prepared and pharmacologically screened as hypolipidemic substances. Some of them showed interesting antilipemic activity but also, unfortunately, high acute toxicity.
mesh_terms: D000588:Amines / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D000960:Hypolipidemic Agents / Q000138:chemical synthesis*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000588:Amines; D000960:Hypolipidemic Agents
vernacular_title: Arilossi e ariltioalchilamine ipolipidemizzanti.