title: An easy and reliable radioimmunoassay of serum androstenedione: age-related normal values in 252 females aged 2 to 70 years.
abstract: A simple, non-chromatographic radioimmunoassay for the measurement of androstenedione (A-dione) in serum and based on a commercially available antiserum is described. The antibody-bound fraction was separated from the free fraction by a gel-centrifugation procedure. The method was used to establish reference values for normal females, based on determination in 252 normal females from 2 to 70 years of age. The data support the statement that the decline with age after puberty in the overall production of A-dione is mainly caused by a reduction in the adreno-derived A-dione, since the mean concentration of A-dione in age-matched pre- and postmenopausal women was very similar
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000735:Androstenedione / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008875:Middle Aged; D011863:Radioimmunoassay; D012016:Reference Values
chemical_list: D000735:Androstenedione