title: Taurocholate, but not taurodehydrocholate, increases biliary permeability to sucrose.
abstract: To determine whether bile salts alter the permeability of the biliary tree to inert solutes, we investigated the effects of taurocholate and taurodehydrocholate on [14C]sucrose bile-to-plasma ratio in the situ perfused rat liver. Sucrose bile-to-plasma ratio remained virtually constant over a 3-h period in untreated rats. Infusing increasing amounts of taurocholate produced the anticipated dose-dependent increase in bile flow and bile salt secretion up to a maximal secretory rate of 278 nmol X min-1 X g liver-1. When the secretory rate was exceeded, bile flow decreased by 22%. Even at doses below the maximal secretory rate, sucrose bile-to-plasma ratio increased in a dose-dependent fashion. To determine whether this was due to recruitment of more permeable centrizonal hepatocytes, the effect of equimolar amounts of taurodehydrocholate was determined. This nonmicelle-forming bile salt led to more marked choleresis than taurocholate but did not affect sucrose bile-to-plasma ratio. We conclude that taurocholate, but not taurodehydrocholate, leads to a dose-dependent increase in biliary permeability.
mesh_terms: D000818:Animals; D001646:Bile / Q000378:metabolism*; D005704:Gallbladder / Q000187:drug effects / Q000378:metabolism / Q000502:physiology*; D007700:Kinetics; D010539:Permeability; D051381:Rats; D013395:Sucrose / Q000378:metabolism*; D013656:Taurocholic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: C019560:taurodehydrocholate; D013395:Sucrose; D013656:Taurocholic Acid