[Patho- and morphogenesis of infectious myocarditis].
An experimental study in white mice infected with influenza virus A1, staphylococcus, Pseudomonas aeruginosa, Escherichia coli or Proteus, showed toxic vascular, stromal and cardiomyocyte damage in the myocardium within the first 2-3 days (circulation disorders, edema, dystrophic and necrotic changes in cardiomyocytes), which by day 3-5 were replaced by inflammation resulting in the formation of myocarditic cardiosclerosis foci by the 3d-4th week. Certain immune disorders were detected in patients with infectious myocarditis; cardiac antigen was found in the serum of 24%, anticardiac antibodies in 22%, positive blast transformation tests in 7.5%, as well as reduced quantities of T cells. Coons's method at late dates after staphylococcal angina revealed antibodies to myocardial structures in 45.7% of patients, and those to connective tissue in 36.1-31.4%. Myocarditis signs were identified in part of those. A scheme is proposed for the pathogenesis of infectious myocarditis.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D000941:Antigens / Q000032:analysis; D006801:Humans; D007239:Infections / Q000150:complications* / Q000276:immunology / Q000473:pathology; D051379:Mice; D009205:Myocarditis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D009206:Myocardium / Q000473:pathology
D000906:Antibodies; D000941:Antigens
Nekotorye voprosy pato- i morfogeneza infektsionnykh miokarditov.