title: Biological availability and pharmacokinetics of tinidazole after single and repeated doses.
abstract: Tinidazole was administered to healthy volunteers and serum concentrations were measured following single oral and intravenous doses and after repeated dosage at different dose levels. The elimination half-time was 12-13 h. Pharmacokinetics did not change with dose, route of administration or repeated dosage. The bioavailability of single oral doses ranged between 88 and 129% with a mean of 99%. Serum concentration curves tended to have double peaks or plateaus at about 4-6 h. 74% of the intravenous dose was eliminated from serum at 24 h, but only 19% was recovered in the urine, suggesting alternative ways of elimination. Excretion in the bile and a subsequent enterohepatic circulation may explain the variations in bioavailability and the shape of the serum concentration curves.
mesh_terms: D000328:Adult; D001682:Biological Availability; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009593:Nitroimidazoles / Q000008:administration & dosage*; D013997:Time Factors; D014011:Tinidazole / Q000008:administration & dosage* / Q000097:blood / Q000652:urine
chemical_list: D009593:Nitroimidazoles; D014011:Tinidazole