Healing of hyaluronic acid-enriched wounds: histological observations.
The influence of an exogenous supply of Na hyaluronate (HA) on the healing of superficial skin wounds in healthy and alloxan-induced diabetic rats was histologically assessed. Rats were treated by topical application on the wound site of a 2% Na hyaluronate solution. A facilitating effect of the HA-enrichment on wound repair processes (particularly epithelial migration and differentiation) was markedly evident in wounded diabetic rats. This result is discussed in terms of a possible favorable influence of an HA-enriched wound environment on cell migratory processes occurring during wound healing.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D004848:Epithelium / Q000473:pathology; D006197:Hair / Q000473:pathology; D006820:Hyaluronic Acid / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000293:injuries / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects*
D006820:Hyaluronic Acid