[Role of terminal deoxyribonucleotidyl transferase in stimulating lymphocyte DNA synthesis as affected by PHA].
3H-thymidine incorporation was measured in DNA of the human lymphocytes from the peripheral blood after its PHA-stimulation in vitro. The increased PHA-stimulation was established after addition to the medium of exogenous terminal deoxynucleotidyl transferase (TDT) for cultures with small level of PHA-stimulation only. TDT without PHA exerted no stimulating action on the culture of lymphocytes.
D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D004253:DNA Nucleotidylexotransferase / Q000494:pharmacology*; D004254:DNA Nucleotidyltransferases / Q000494:pharmacology*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D010835:Phytohemagglutinins / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D010835:Phytohemagglutinins; D014316:Tritium; D004247:DNA; D004254:DNA Nucleotidyltransferases; D004253:DNA Nucleotidylexotransferase; D013936:Thymidine
Rol' kontsevoĭ dezoksinukleotidiltransferazy v stimuliatsii sinteza DNK limfotsitov pod vliianiem FGA.