Lipofuscin in lymphocytes and plasma cells in aging.
The age-related changes in spleen and lymph node lymphocytes and plasma cells of Wistar rats and in the peripheral lymphocytes of healthy human individuals were examined. Similar changes were described in human and rat lymphocytes and plasma cells consisting of mitochondrial lesions. The cristae of the mitochondria disappeared and were replaced by myelin-like structure, lamellar structure, electron-dense and electron-translucent material. It is supposed that this material corresponds to lipofuscin.
D000328:Adult; D000368:Aged; D000375:Aging; D000818:Animals; D006801:Humans; D008062:Lipofuscin / Q000378:metabolism*; D008198:Lymph Nodes / Q000166:cytology*; D008214:Lymphocytes / Q000378:metabolism* / Q000648:ultrastructure; D008875:Middle Aged; D010860:Pigments, Biological / Q000378:metabolism*; D010950:Plasma Cells / Q000378:metabolism* / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000166:cytology*
D008062:Lipofuscin; D010860:Pigments, Biological