Calcium-containing mitochondrial granules in neurohypophysial axon terminals disappear following vasopressin treatment of Brattleboro rats.
The presence of intramitochondrial calcium-containing electron-dense granules was demonstrated in axon terminals of chronically hyperactive neurosecretory neurons of untreated homozygous Brattleboro rats. Following vasopressin treatment for 30 days, which has been shown to attenuate this neuronal hyperactivity, calcium-containing deposits could not be detected in mitochondria. It is concluded that the presence of intramitochondrial calcium-containing dense deposits is connected with the functional state of neurosecretory neurons.
D000818:Animals; D001369:Axons / Q000502:physiology*; D002118:Calcium / Q000502:physiology*; D003594:Cytoplasmic Granules / Q000502:physiology* / Q000648:ultrastructure; D008928:Mitochondria / Q000502:physiology* / Q000648:ultrastructure; D009411:Nerve Endings / Q000502:physiology*; D010904:Pituitary Gland, Posterior / Q000502:physiology* / Q000648:ultrastructure; D051381:Rats; D011910:Rats, Brattleboro / Q000502:physiology*; D011922:Rats, Mutant Strains / Q000502:physiology*; D014667:Vasopressins / Q000494:pharmacology*
D014667:Vasopressins; D002118:Calcium