Circadian changes in the elimination of misonidazole in mouse.
Intraperitoneal doses of Misonidazole were administered at 15.00 hours and 03.00 hours to Balb c/cenlco mice standardized in controlled environmental cages for 3 weeks before the experiment. Non linear pharmacokinetic and temporal variations in the apparent half life were obtained at higher doses.
D000818:Animals; D002940:Circadian Rhythm; D005260:Female; D006207:Half-Life; D007700:Kinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D008920:Misonidazole / Q000378:metabolism*; D009593:Nitroimidazoles / Q000378:metabolism*; D013997:Time Factors
D009593:Nitroimidazoles; D008920:Misonidazole