title: Clearance and tissue distribution of intravenously injected Salmonella typhi polysaccharide in rabbits.
abstract: The interaction of Freeman polysaccharide of Salmonella typhi with blood and tissues of rabbits was studied by radioimmunoassay. After intravenous injection of 1.0 mg of S. typhi Freeman polysaccharide, a rapid clearance phase (t1/2, 6.0 min) was followed by a slower clearance period (t1/2, 55.2 min). These results suggest first, that the distribution of whole lipopolysaccharide is a function of how the polysaccharides are handled by the host; further, that the O side chain determines how and where lipopolysaccharide is cleared from the circulatory system; and finally, that Freeman polysaccharide regulates the toxicity of lipopolysaccharide by influencing its clearance from blood.
mesh_terms: D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D007106:Immune Sera / Q000302:isolation & purification; D007275:Injections, Intravenous; D008050:Lipid A / Q000378:metabolism*; D011135:Polysaccharides, Bacterial / Q000008:administration & dosage / Q000378:metabolism*; D011817:Rabbits; D011863:Radioimmunoassay / Q000379:methods; D012485:Salmonella typhi; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D007106:Immune Sera; D008050:Lipid A; D011135:Polysaccharides, Bacterial