Reduced nocturnal morphine analgesia in mice following a geomagnetic disturbance.
Latency to respond to an aversive thermal stimulus and the degree of analgesia induced by morphine were examined in mice injected with either isotonic saline or morphine sulfate (10 mg/kg) during midscotophase of a 12:12 h LD cycle. When mean response latencies were compared to the degree of geomagnetic disturbance (Ap index) present on test days, it was found that during the geomagnetic storm on December 17th, 1982, a significant reduction (P less than 0.01) in response latency was evident in both saline- and morphine-treated mice. The reduction in response latencies was greater, and lasted longer in the morphine-treated animals. It is suggested that the pineal gland may mediate this biomagnetic effect.
D000698:Analgesia; D000818:Animals; D002940:Circadian Rhythm; D008280:Magnetics; D008297:Male; D051379:Mice / Q000502:physiology*; D008815:Mice, Inbred Strains; D009020:Morphine; D010812:Physical Stimulation; D011930:Reaction Time
D009020:Morphine