title: A new enkephalin analogue: trans-4-hydroxycinnamoyl-glycyl-glycyl-phenylalanyl-leucine. Synthesis and biological properties.
abstract: A new analogue of the leucine-enkephalin in which the N-terminal tyrosine has been replaced by trans-4-hydroxycinnamic acid, has been synthetized by liquid-phase coupling methods. The central cardiovascular effects of this analogue were investigated and the results discussed.
mesh_terms: D000818:Animals; D001681:Biological Assay; D001794:Blood Pressure / Q000187:drug effects; D002855:Chromatography, Thin Layer; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
chemical_list: D007202:Indicators and Reagents; D004743:Enkephalin, Leucine; C039938:enkephalin-Leu, 4-hydroxycinnamoyl(1)-