Use of midazolam and buprenorphine in combination anaesthesia.
In this comparative study in 102 female patients, midazolam or thiopentone was used as the sleep-inducing component in combination anaesthesia. During anaesthesia, three different analgesics: fentanyl, oxycodone and buprenorphine were tested. The sleep-inducing effect of midazolam was clearly slower in onset than that of thiopentone, but in other respects midazolam was a satisfactory inducing agent for general anaesthesia. Patients receiving midazolam and/or buprenorphine needed an additional dose of muscle relaxant less often than those receiving thiopentone and fentanyl or oxycodone. Buprenorphine produced a long postoperative analgesia lasting up to 10 hours, but these patients were also postoperatively drowsier, which gave a lower postanesthetic recovery score.
D000328:Adult; D000768:Anesthesia, General; D001569:Benzodiazepines; D002047:Buprenorphine; D005260:Female; D005283:Fentanyl; D005831:Genital Diseases, Female / Q000601:surgery; D006801:Humans; D008874:Midazolam; D008875:Middle Aged; D009019:Morphinans; D010098:Oxycodone; D011229:Preanesthetic Medication
D009019:Morphinans; D001569:Benzodiazepines; D002047:Buprenorphine; D010098:Oxycodone; D008874:Midazolam; D005283:Fentanyl