Effect of intra-pregastric administration of nitrite on erythrocyte GSH and GSSG contents of male golden hamster (Mesocricetus auratus).
Effect of single dose of nitrite on the formation of methaemoglobin, the erythrocyte content and redox state of glutathione of male golden hamster were investigated up to 20 min. The marked depletion of GSH following the oxidation of haemoglobin was observed in nitrite treated animals. Conversely, the GSSG contents of animals given 20 and 25 mg of nitrite were slightly higher than that of normal but not difference in total glutathione. The respective difference of the redox electrode potential between saline and nitrite treated animals was -84 mV at 20 mg and -125 mV at 25 mg of nitrite 20 min after administration.
D000818:Animals; D006224:Cricetinae; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D005978:Glutathione / Q000031:analogs & derivatives* / Q000097:blood*; D019803:Glutathione Disulfide; D008297:Male; D008647:Mesocricetus; D009573:Nitrites / Q000008:administration & dosage*; D013270:Stomach; D013997:Time Factors
D009573:Nitrites; D005978:Glutathione; D019803:Glutathione Disulfide