[Effect of vitamin B12 on liver and kidney DNA methylation in guinea pigs in the presence of methionine and ATP].
Changes of 5-methylcytosine (m5C) content in DNA of guinea-pigs' liver and kidney under the influence of vitamin B12 in the presence of methionine and ATP have been studied. After B12 injection m5C quantity in liver DNA increases in 1,4 times, in kidney DNA in 1,6 times. The methionine and ATP injection lowers B12 effect on the DNA methylation in liver and kidney.
D044503:5-Methylcytosine; D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D003596:Cytosine / Q000031:analogs & derivatives / Q000378:metabolism; D004247:DNA / Q000378:metabolism*; D004347:Drug Interactions; D006168:Guinea Pigs; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008715:Methionine / Q000494:pharmacology*; D008745:Methylation; D014805:Vitamin B 12 / Q000494:pharmacology*
D044503:5-Methylcytosine; D003596:Cytosine; D000255:Adenosine Triphosphate; D004247:DNA; D008715:Methionine; D014805:Vitamin B 12
Vliianie vitamina B12 na metilirovanie DNK pecheni i pochek morskikh svinok v prisutstvii metionina i ATF.