Evidence for a magnesium-sparing action by amiloride during renal clearance studies in rats.
The potassium-sparing diuretic, amiloride, reduced the fractional excretion of magnesium in anaesthetized rats. Alterations in glomerular filtration rate (GFR), the filtered load of magnesium, arterial blood pressure, the status of the extracellular fluid volume, plasma aldosterone concentration and acid-base balance were not involved. It was concluded that amiloride exerted a magnesium-sparing effect by a direct renal action.
D000450:Aldosterone / Q000097:blood; D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004573:Electrolytes / Q000097:blood; D005919:Glomerular Filtration Rate; D006400:Hematocrit; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D004573:Electrolytes; D011719:Pyrazines; D000450:Aldosterone; D000584:Amiloride; D008274:Magnesium