Coma and crystalluria: a massive primidone intoxication treated with haemoperfusion.
The present paper describes a patient who was in danger of dying from a massive primidone overdose. She was comatose, hypotensive and in acute renal failure with crystalluria. Because of her clinical condition and high plasma primidone level (209 mg/l) haemoperfusion was instituted. Both the calculated drug clearances and the remarkable improvement in the patient's clinical condition suggest that haemoperfusion was very effective.
D000368:Aged; D002606:Charcoal / Q000627:therapeutic use; D003128:Coma / Q000139:chemically induced* / Q000628:therapy; D005260:Female; D006207:Half-Life; D006464:Hemoperfusion; D006801:Humans; D007700:Kinetics; D010634:Phenobarbital / Q000097:blood; D010657:Phenylethylmalonamide / Q000097:blood; D011324:Primidone / Q000378:metabolism / Q000506:poisoning*
D011324:Primidone; D002606:Charcoal; D010657:Phenylethylmalonamide; D010634:Phenobarbital