Comparative ototoxicity of dibekacin and netilmicin in guinea pigs.
The cochleo- and vestibulotoxicity of dibekacin and netilmicin were compared in a guinea pig model. Both aminoglycosides were administered subcutaneously for 21 days at the dose level of 150 mg/kg/day. Control animals were injected with saline. Dibekacin-treated animals showed a significant (P less than 0.05) increase in the thresholds of the Preyer pinna reflex and the VIIIth nerve compound action potential in response to sound click stimulation. Moreover, a deterioration of the electrophysiologic auditory response and an almost complete suppression of the post-rotatory nystagmus were detected. In contrast, netilmicin did not induce any significant change in auditory and vestibular functions as compared to the control group. Our results demonstrated that netilmicin was devoid of ototoxicity in the guinea pig, while dibekacin provoked mild cochlear and severe vestibulotoxicity.
D000200:Action Potentials; D000818:Animals; D001309:Auditory Threshold; D003051:Cochlea / Q000503:physiopathology; D003982:Dibekacin / Q000633:toxicity*; D005072:Evoked Potentials, Auditory; D005260:Female; D005839:Gentamicins / Q000633:toxicity*; D006168:Guinea Pigs; D007612:Kanamycin / Q000031:analogs & derivatives*; D007759:Labyrinth Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology; D008297:Male; D009428:Netilmicin / Q000633:toxicity*; D009759:Nystagmus, Pathologic / Q000139:chemically induced
D005839:Gentamicins; D003982:Dibekacin; D009428:Netilmicin; D007612:Kanamycin