Long-acting contraceptive agents: esters of norethisterone with alpha- and/or beta-chain branching.
The synthesis of eighteen esters of norethisterone (17 alpha-ethynyl-17 beta-hydroxyestr-4-en-3-one) is described. These all possess some form of alpha- and/or beta-substitution in the ester side-chain. The work was undertaken in order to evaluate any long-acting fertility control effect intrinsic in such compounds. A pentamethyl disiloxy ether was also included in the group of substances prepared for testing because of its similar substitution pattern.
D004952:Esters; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009640:Norethindrone / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D013053:Spectrophotometry; D013329:Structure-Activity Relationship
D004952:Esters; D007202:Indicators and Reagents; D009640:Norethindrone