Evidence for an increase in [3H]spiperone binding in hypothalamic nuclei during the development of spontaneous hypertension in the rat.
The in vivo binding of [3H]spiperone was measured in discrete areas of the hypothalamus in 7, 9 and 16 weeks old spontaneously hypertensive rats (SHR) and age matched normotensive Wistar Kyoto (WKY) controls. The specific binding of [3H]spiperone was significantly higher in the four different hypothalamic regions (H1, H2, H3, H4) that we have tested in 7 or 9 weeks old SHR than in age matched WKY controls. At 16 weeks a significant increase was only present in H3. These results suggest that dopaminergic hypothalamic neurons might be implicated in the onset of hypertension in the rat.
D000818:Animals; D001794:Blood Pressure; D002090:Butyrophenones / Q000378:metabolism*; D004298:Dopamine / Q000502:physiology; D006973:Hypertension / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism* / Q000502:physiology; D008297:Male; D009474:Neurons / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000502:physiology; D013134:Spiperone / Q000378:metabolism*; D014316:Tritium
D002090:Butyrophenones; D011954:Receptors, Dopamine; D014316:Tritium; D013134:Spiperone; D004298:Dopamine