Decrease of lactoferrin concentration in the tears of myotonic muscular dystrophy patients.
Tears from myotonic muscular dystrophy (MMD) patients and normal controls were analyzed for their tear proteins by sodium dodecyl sulfate-polyacrylamide gel electrophoresis. Lactoferrin comprised about 18% of the total tear protein in MMD patients as opposed to about 27% in normals. The albumin content relative to total protein in MMD tears was about 25% while the same value for normals is 13%. The lactoferrin/albumin ratio, was about 0.8 for MMD patients and about 2.1 for normals.
D004910:Erythrocyte Membrane / Q000032:analysis; D006801:Humans; D007122:Immunoelectrophoresis / Q000379:methods; D007781:Lactoferrin / Q000032:analysis*; D007782:Lactoglobulins / Q000032:analysis*; D009136:Muscular Dystrophies / Q000378:metabolism*; D012394:Rosaniline Dyes; D013666:Tears / Q000032:analysis*
D007782:Lactoglobulins; D012394:Rosaniline Dyes; D007781:Lactoferrin; C004692:coomassie Brilliant Blue