title: The influence of the choroid plexus on the concentration of prealbumin in CSF.
abstract: Prealbumin and albumin concentrations were measured in homogenates of choroid plexus, ventricular and lumbar CSF, and in serum. The passive permeability-independent prealbumin concentration was estimated by subtracting from the total concentration that portion which enters the plexus and CSF by a passive molecular sieve effect, assuming that the diffusion of albumin and prealbumin is similar. The passive permeability-independent prealbumin concentration was highest in homogenates of the choroid plexus (mean = 56 micrograms/g). It was almost 3 times that in ventricular CSF (mean = 18 micrograms/ml). The passive permeability-independent concentration decreased only slightly during passage from the ventricular to the lumbar CSF space (mean = 16 micrograms/ml). These data suggest that much of the prealbumin in CSF enters the ventricular CSF via the choroid plexus by a mechanism different from that responsible for the transit of albumin.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001812:Blood-Brain Barrier; D002199:Capillary Permeability; D002552:Cerebral Ventricles; D002831:Choroid Plexus / Q000032:analysis* / Q000098:blood supply; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011228:Prealbumin / Q000134:cerebrospinal fluid*; D012016:Reference Values
chemical_list: D011228:Prealbumin