Nitrous oxide alters the pattern of myelin proteins in the nervous system of the fruit bat Roussettus aegyptiacus.
Proteins of the myelin membrane were separated by SDS-polyacrylamide electrophoresis. The protein patterns obtained from myelin from the forebrain, medulla, cervical and thoracic spinal cord and phrenic nerve of normal animals were compared with those obtained from animals given nitrous oxide or nitrous oxide plus folinic acid. A shift from high molecular weight proteins to lower molecular weight proteins was seen in all regions studied in animals given N2O and folinic acid. These changes were seen also in the medulla and thoracic spinal cord of animals given N2O alone. Peripheral nerve showed a slight increase in the amounts of Po at the expense of P3 and P2 in N2O and folinic acid-treated animals.
D000818:Animals; D001923:Brain Chemistry; D002462:Cell Membrane / Q000187:drug effects; D002685:Chiroptera / Q000378:metabolism*; D008565:Membrane Proteins / Q000378:metabolism; D009185:Myelin Proteins / Q000032:analysis*; D009420:Nervous System / Q000032:analysis*; D009609:Nitrous Oxide / Q000506:poisoning*; D010791:Phrenic Nerve / Q000032:analysis; D012436:S-Adenosylmethionine / Q000378:metabolism; D013116:Spinal Cord / Q000032:analysis
D008565:Membrane Proteins; D009185:Myelin Proteins; D012436:S-Adenosylmethionine; D009609:Nitrous Oxide