title: Computed tomography in hepatolenticular degeneration (Wilson's disease).
abstract: Fifteen cases of hepatolenticular degeneration have been studied by means of computerized cranial tomography (CT). The common abnormalities were hypodense areas in the regions of the basal ganglia, in 9 cases; ventricular dilatation, in 7 cases; cortical atrophy, in 5 cases and brain-stem atrophy, in 4 cases. CT abnormalities were most common and most marked in patients with neurological presentations, but 1 of 3 asymptomatic patients discovered by the genetic screening of the affected family had hypodense areas in bilateral lenticular nuclei.
mesh_terms: D001284:Atrophy / Q000000981:diagnostic imaging / Q000473:pathology; D001933:Brain Stem / Q000000981:diagnostic imaging / Q000473:pathology; D002114:Calcinosis / Q000000981:diagnostic imaging / Q000473:pathology; D002540:Cerebral Cortex / Q000000981:diagnostic imaging / Q000473:pathology; D003342:Corpus Striatum / Q000000981:diagnostic imaging* / Q000473:pathology; D006527:Hepatolenticular Degeneration / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D014057:Tomography, X-Ray Computed