Specificity of the effect of desglycinamide (8-D-arginine) deaminovasopressin on short--term memory.
The effect of desglycinamide (8-D-arginine) deaminovasopressin (desgly NH2 dDAVP) on learning was studied in rats using the conditioned taste aversion (CTA) paradigm. Desgly NH2 dDAVP (3 micrograms/kg) applied 40 min before presentation of the gustatory CS (0.1 % saccharin) did not affect CTA formation, when the visceral US (0.15 mol/l LiCl, 2 % body weight) was applied after a 1 h delay. With 2 h CS-US delay the same dosage of the peptide caused CTA impairment, manifested by weaker and faster decaying aversion to saccharin. The above effect of the peptide was blocked by post-CS anesthesia (pentobarbital 40 mg/kg). It is suggested that desgly NH2 dDAVP affects learning indirectly, by increased arousal interfering with the persistence of the short-term gustatory traces in the relatively long CS-US interval.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology*; D008236:Lypressin / Q000494:pharmacology; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects*; D009419:Nerve Tissue Proteins / Q000494:pharmacology; D051381:Rats
D009419:Nerve Tissue Proteins; D001127:Arginine Vasopressin; D008236:Lypressin; D003894:Deamino Arginine Vasopressin