Lack of cross-reaction between DNCB and chloramphenicol.
Although one study has reported a cross-reactivity between DNCB and chloramphenicol in 40% of patients, other investigators have been unable to confirm the existence of any cross reaction. The purpose of this study is to determine whether sensitization of patients to DNCB poses a risk of cross reaction to chloramphenicol. In the present study, 100 consecutive patients who were sensitized to DNCB failed to show a single reaction to patch testing with chloramphenicol in a 1% ointment. The discrepancy between these results may be explained by a possible misinterpretation of a primary irritant reaction as an allergic contact reaction in the original report.
D002701:Chloramphenicol / Q000009:adverse effects / Q000276:immunology*; D003429:Cross Reactions; D003877:Dermatitis, Contact / Q000209:etiology; D004137:Dinitrochlorobenzene / Q000009:adverse effects / Q000276:immunology*; D006801:Humans; D009578:Nitrobenzenes / Q000276:immunology*; D010328:Patch Tests
D004137:Dinitrochlorobenzene; D009578:Nitrobenzenes; D002701:Chloramphenicol