Gastric cytoprotective effects of vitamin A and other carotenoids.
The effects of vitamin A and some carotenoids (beta-carotene, beta-cryptoxanthin, zeaxanthin, lutein, capsorubin, capsanthin, capsanthol and lycopene) were studied (a) on the development of acute gastric mucosal lesions produced by topical application of 0.6 M HCl and (b) on gastric secretion in 4-h pylorus-ligated rats. It was found (a) that vitamin A, beta-carotene, beta-cryptoxanthin, zeaxanthin and lutein significantly inhibited the development of gastric mucosal lesions produced by 0.6 M HCl, while capsorubin, capsanthin, capsanthol and lycopene failed to prevent the development of such lesions; and (b) that vitamin A, beta-carotene, beta-cryptoxanthin, zeaxanthin and lutein, i.e., the carotenoids which exerted a cytoprotective effect, had no inhibitory effect on gastric acid secretion in 4-h pylorus-ligated rats. The possible relationship between chemical structure and gastric cytoprotection is discussed.
D000818:Animals; D002338:Carotenoids / Q000031:analogs & derivatives / Q000494:pharmacology*; D065366:Cryptoxanthins; D005753:Gastric Mucosa / Q000187:drug effects*; D006851:Hydrochloric Acid / Q000494:pharmacology; D014975:Lutein / Q000494:pharmacology; D000077276:Lycopene; D051381:Rats; D014801:Vitamin A / Q000494:pharmacology*; D024341:Xanthophylls; D065146:Zeaxanthins; D019207:beta Carotene
D065366:Cryptoxanthins; D024341:Xanthophylls; D065146:Zeaxanthins; D019207:beta Carotene; D014801:Vitamin A; C040185:capsanthol; D002338:Carotenoids; C006889:capsanthin; C035624:capsorubin; D006851:Hydrochloric Acid; D000077276:Lycopene; D014975:Lutein