The effect of molybdenum upon blood serum enzymatic ceruloplasmin activity in rats.
Experiments were carried out on 61 male and female Wistar rats. Following 21-day intraperitoneal administration of molybdenum (Na2MoO4 X 2H2O), significant differences in the level of blood serum ceruloplasmin were noted in female rats depending upon the applied dose of molybdenum. In analogous groups of male rats no statistically significant differences were observed, which might indicate that the effect of molybdenum upon enzymatic ceruloplasmin activity is sex-related. The rats on an increased dietary level of 14 ppm molybdenum, of 10.8 ppm copper content and 507 ppm inorganic sulphur, showed decreased blood serum ceruloplasmin activity irrespective of their sex.
D000818:Animals; D002570:Ceruloplasmin / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D008982:Molybdenum / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D008982:Molybdenum; D002570:Ceruloplasmin