[Structural changes in influenza virus RNA during its attenuation].
Changes in structures of only two genes of influenza virus--M and NS genes were found during virus attenuation by the method of oligonucleotide mapping. Such changes were observed in virulent and attenuated viruses (passages 10-23 in chick embryos) by comparing intermediate variants of the virus (passages 11-16 in chick embryos). These results allow us to conclude the important role of these genes in virus attenuation and in connection with virulence of the virus.
D000818:Animals; D002642:Chick Embryo; D004591:Electrophoresis, Polyacrylamide Gel; D005814:Genes, Viral; D006801:Humans; D009980:Influenza A virus / Q000235:genetics* / Q000472:pathogenicity; D009841:Oligonucleotides / Q000032:analysis; D012367:RNA, Viral / Q000032:analysis / Q000235:genetics*; D013997:Time Factors; D014771:Virion / Q000235:genetics*; D014774:Virulence
D009841:Oligonucleotides; D012367:RNA, Viral
Strukturnye izmeneniia RNK virusa grippa v protsesse ego atteniuatsii.