[Cardionecrotic effect of ethanol, acetaldehyde and teturam in acute experiments on rats].
Acute rat experiments have demonstrated that ethanol and acetaldehyde can produce cardionecrotic affect, provided they are maintained at high levels in the blood via inhalation intragastric (for ethanol) or repeated intraperitoneal (for acetaldehyde) administration. Teturam in doses producing blood acetaldehyde rise has similar effect. No alterative effects of ethanol and acetaldehyde could be demonstrated in isolated perfused hearts. The fact that this necrogenic effect is present in in-vivo experiments and absent in the isolated heart suggests that the action of ethanol and acetaldehyde may be mediated.
D000079:Acetaldehyde / Q000009:adverse effects*; D000208:Acute Disease; D000818:Animals; D004221:Disulfiram / Q000009:adverse effects*; D004719:Endomyocardial Fibrosis / Q000139:chemically induced*; D000431:Ethanol / Q000009:adverse effects*; D008297:Male; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D051381:Rats
D000431:Ethanol; D000079:Acetaldehyde; D004221:Disulfiram
Kardionekroticheskoe deĭstvie étanola, atsetal'degida i teturama v ostrom eksperimente na krysakh.