Inverse relationship of serum LDL cholesterol and the LDL/HDL cholesterol ratio to liver microsomal enzyme induction in man.
The association of serum LDL cholesterol and the LDL/HDL cholesterol ratio, the major positive risk factors of coronary heart disease, to hepatic microsomal enzyme induction assessed by liver cytochrome P-450, was investigated in 18 subjects who were treated with inducing anticonvulsants. In subjects with normal liver histology, LDL cholesterol and the LDL/HDL cholesterol ratio were inversely proportional to the magnitude of induction. Strong induction was associated with a low LDL cholesterol level. The serum cholesterol distribution profile and the low LDL/HDL cholesterol ratio associated with induction are characteristic of low risk of coronary heart disease. The present findings support studies showing a positive association between HDL cholesterol and induction and suggesting a new therapeutic approach to atherosclerotic vascular disease.
D000328:Adult; D000927:Anticonvulsants / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D003327:Coronary Disease / Q000209:etiology; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004790:Enzyme Induction / Q000187:drug effects; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood*; D008862:Microsomes, Liver / Q000201:enzymology*; D008875:Middle Aged
D000927:Anticonvulsants; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D003577:Cytochrome P-450 Enzyme System; D002784:Cholesterol