Effect of 3-MC on cholesterolemia and hepatic G-6-PD.
The effect of 3-methylcholanthrene (3-MC), an inducer of the mixed function oxidases system (MFOS), was investigated in male Wistar rats in relation to plasmatic cholesterol and hepatic glucose-6-phosphate dehydrogenase (G-6-PD). 3-MC induced an increase in total cholesterol; the maximal increase was seen 2 days after treatment (50%). The increase in total cholesterol was followed by an augmentation in cholesterol HDL. 3-MC treatment resulted also in an increase of hepatic G-6-PD.
D000818:Animals; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism*; D008075:Lipoproteins, HDL / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D008748:Methylcholanthrene; D002784:Cholesterol; D005954:Glucosephosphate Dehydrogenase