title: The lymphocyte lysosomes in ontogeny of man.
abstract: During intrauterine fetal development, the gradual formation of enzyme-positive lysosomes containing acid phosphatase, beta-glucuronidase, and N-acetyl-beta-glucosaminidase takes place within peripheral lymphocytes. During the first 5 decades of human life the lysosomal apparatus of lymphocytes containing the above enzymes exhibits relative stability whereas the final stages of man's ontogenetic development between 6th and 9th decade of life are characterized by the disintegration of enzyme-positive lysosomes.
mesh_terms: D000118:Acetylglucosaminidase / Q000378:metabolism; D000135:Acid Phosphatase / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D002648:Child; D002675:Child, Preschool; D005260:Female; D005312:Fetal Blood; D005966:Glucuronidase / Q000378:metabolism; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D008214:Lymphocytes / Q000201:enzymology*; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D008875:Middle Aged
chemical_list: D000135:Acid Phosphatase; D005966:Glucuronidase; D000118:Acetylglucosaminidase