[Permeation of triamcinolone acetonide and zinc oxide from a shake lotion].
Triamcinolone-acetonide crystals suspended in a zinc oxide shake lotion permeate the deeper skin layers especially if applied to a damaged horny layer. The influx rate of the corticosteroid is approximately 20 times higher in damaged skin (e.g. removing of horny layer by stripping) than in healthy skin. Zinc oxide is absorbed by the middle and lower layers of the horny layer respectively epidermis, out of the triamcinolone-acetonide shake lotion. The corticosteroid and zinc component as well as a physical properties of the shake lotion have a therapeutical effect.
D000328:Adult; D004817:Epidermis / Q000378:metabolism; D005260:Female; D005990:Glycerol; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D014677:Pharmaceutical Vehicles; D012869:Skin Absorption; D013054:Spectrophotometry, Atomic; D013535:Suspensions; D013627:Talc; D014222:Triamcinolone Acetonide / Q000378:metabolism*; D014316:Tritium; D015032:Zinc / Q000378:metabolism*; D015034:Zinc Oxide / Q000378:metabolism*
D014677:Pharmaceutical Vehicles; D013535:Suspensions; D014316:Tritium; D013627:Talc; D014222:Triamcinolone Acetonide; D015032:Zinc; D005990:Glycerol; D015034:Zinc Oxide
Permeation von Triamcinolon-Acetonid und Zinkoxid aus einer Schüttelmixtur.