Intracranial myeloid metaplasia: diagnosis by CT and Fe52 scans and treatment by cranial irradiation.
A patient with longstanding agnogenic myeloid metaplasia developed a progressive dementia. CT scanning demonstrated multiple intracranial masses, and a Fe52 bone marrow scan demonstrated erythroid activity within the masses and confirmed the suspicion of extra-medullary hematopoiesis. A potentially hazardous biopsy was avoided, and a course of cranial irradiation was administered, resulting in regression of the masses and clearing of the patient's dementia. Fe52 scintigraphy provides a specific and useful diagnostic approach which may eliminate the need for invasive procedures.
D001921:Brain / Q000000981:diagnostic imaging / Q000528:radiation effects; D001927:Brain Diseases / Q000175:diagnosis*; D003704:Dementia / Q000209:etiology; D005260:Female; D006529:Hepatomegaly / Q000209:etiology; D006801:Humans; D007504:Iron Radioisotopes; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000150:complications / Q000175:diagnosis* / Q000532:radiotherapy; D011877:Radionuclide Imaging; D013163:Splenomegaly / Q000209:etiology; D014057:Tomography, X-Ray Computed
D007504:Iron Radioisotopes