title: Antimicrobial activity and other in vitro properties of cefoperazone A, the principal metabolite of cefoperazone sodium.
abstract: Cefoperazone A, the principal metabolite of cefoperazone, was found to have an antimicrobial activity ranging from slightly below to 16-fold less than that of the parent drug. Like cefoperazone, the metabolite is bactericidal, penetrates well into bacterial cells, and has moderate beta-lactamase stability, some strains of members of the family Enterobacteriaceae produce an inoculum effect on the metabolite activity.
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D002438:Cefoperazone / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology; D004355:Drug Stability; D006801:Humans; D006868:Hydrolysis; D008826:Microbial Sensitivity Tests
chemical_list: C039259:cefoperazone A; D002438:Cefoperazone