title: Suppression of post-apheresis autoantibody rebound in cryoglobulinemia and cold agglutinin hemolytic anemia.
abstract: We studied the effect of immunosuppressive treatment on the autoantibody rebound that follows autoantibody withdrawal accomplished by extracorporeal plasma treatment. The study was carried out on 9 patients, 8 having essential mixed cryoglobulinemia and 1 cold agglutinin hemolytic anemia. As immunosuppressive drugs we used either cyclophosphamide and prednisolone or arabinoside C and cyclophosphamide. The effect of immunosuppressive treatment on autoantibody rebound (Igm anti-IgG; IgM cold agglutinins) varied widely, a suppressive effect of varying degree having been observed in about half the cases treated with either drug regimen.
mesh_terms: D000744:Anemia, Hemolytic, Autoimmune / Q000188:drug therapy* / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D003080:Cold Temperature; D003449:Cryoglobulinemia / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010265:Paraproteinemias / Q000188:drug therapy*; D010951:Plasma Exchange / Q000379:methods
chemical_list: D001323:Autoantibodies; D007166:Immunosuppressive Agents