A comparison of the effects of flubendazole and thiabendazole on the larvae of Angiostrongylus cantonensis, Trichinella spiralis, Diphyllobothrium erinacei and Hymenolepis nana in mice.
Flubendazole or thiabendazole were administered orally to mice harbouring larvae of Angiostrongylus cantonensis, Trichinella spiralis, Diphyllobothrium erinacei or Hymenolepis nana 5-10, 28-33, 21-26 and 1-6 days post-infection respectively. All the mice infected with A. cantonensis were completely cured after treatment with flubendazole at 5 mg/kg/day for 6 days. No noticeable damage was found in the cerebral hemispheres of the mice treated with flubendazole and examined under a dissecting microscope. On the other hand, larvae were found in or on the cerebral hemispheres showing obvious haemorrhage in the control mice. The mice treated with flubendazole gained weight while the control mice lost weight. No larvicidal effect of thiabendazole on A. cantonensis was found at a dose of 10 mg/kg/day for 6 days. The mean reduction of larval T. spiralis in mice treated with flubendazole at 5, 50 and 100 mg/kg/day for 6 days was 64, 100 and 99% respectively. In comparison, thiabendazole showed no efficacy against T. spiralis larvae at 50 or 100 mg/kg/day. Mice harbouring plerocercoids of D. erinacei or H. nana larvae were not cured with either flubendazole or thiabendazole at 50 or 100 mg/kg/day for 6 days.
D000801:Angiostrongylus / Q000187:drug effects*; D000818:Animals; D000969:Antinematodal Agents / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D004170:Diphyllobothrium / Q000187:drug effects*; D005260:Female; D006373:Helminthiasis / Q000188:drug therapy; D006926:Hymenolepis / Q000187:drug effects*; D007814:Larva / Q000187:drug effects; D008297:Male; D008463:Mebendazole / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000633:toxicity; D008681:Metastrongyloidea / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D013827:Thiabendazole / Q000494:pharmacology*; D014234:Trichinella / Q000187:drug effects*
D000969:Antinematodal Agents; D001562:Benzimidazoles; D008463:Mebendazole; D013827:Thiabendazole; C018945:flubendazole