Stromal DNA synthesis is stimulated by young, but not serially aged, mouse mammary epithelium.
Ductal elongation in young, proliferating mouse mammary gland is associated with a zone of DNA synthesis in stroma surrounding the end buds. In contrast, slowly growing, serially aged tissue fails to elicit a significant elevation of stromal DNA synthetic activity. Since fatty stroma is required for normal mammary growth and morphogenesis, this altered interaction may be a significant factor in the aging of mammary epithelium.
D000273:Adipose Tissue / Q000166:cytology; D000818:Animals; D002450:Cell Communication; D002453:Cell Cycle; D002470:Cell Survival; D046508:Culture Techniques; D004261:DNA Replication; D004847:Epithelial Cells; D005260:Female; D008321:Mammary Glands, Animal / Q000166:cytology*; D051379:Mice