Pharmacokinetics of antipyrine, paracetamol, and morphine in rat at 71 ATA.
The pharmacokinetics of [14C]antipyrine, [3H]paracetamol, and [3H]morphine were studied in male Wistar rats at 1 ATA and then at 71 ATA, each animal being its own control. Separate control groups were studied at 1 ATA in order to test the validity of the one-way crossover protocol. The drugs were injected through a femoral venous catheter, and blood was sampled from a catheter in the femoral artery. There were no significant differences in the biological half-life (T1/2), the apparent volume of distribution (Vd), and the clearance (C) of antipyrine and paracetamol. Likewise, there was no appreciable effect of high pressure on the blood concentration profile of morphine.
D000082:Acetaminophen / Q000378:metabolism*; D000818:Animals; D000983:Antipyrine / Q000378:metabolism*; D001273:Atmosphere Exposure Chambers; D001274:Atmospheric Pressure; D002250:Carbon Radioisotopes; D007700:Kinetics; D008297:Male; D009020:Morphine / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014316:Tritium
D002250:Carbon Radioisotopes; D014316:Tritium; D000082:Acetaminophen; D009020:Morphine; D000983:Antipyrine