Renal function and 1 alpha-hydroxyvitamin D3 in rabbits with normal renal function and renal insufficiency.
The effect of 1 alpha-hydroxyvitamin D3 (1 alpha OHD3) on the renal clearance of creatinine was investigated in groups of rabbits with stable renal insufficiency and normal controls. Urine was collected in the two groups for two one-week periods during placebo treatment. Then, 1 alpha OHD3, 0.02 micrograms/kg BW/day, was administered orally and urine was collected during the next two weeks. Weekly blood samples were obtained. The treatment had no significant effect on the serum concentrations of calcium and phosphate in either group. Creatinine clearance decreased significantly in both groups during the 1 alpha OHD3 treatment (p less than 0.05), mainly due to a decreased urinary excretion of creatinine. It is suggested that changes in the renal tubular handling of creatinine caused by 1 alpha OHD3 may be the explanation of the observed effect.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002118:Calcium / Q000097:blood; D003404:Creatinine / Q000097:blood / Q000378:metabolism / Q000652:urine; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D007668:Kidney / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008274:Magnesium / Q000097:blood; D008297:Male; D010710:Phosphates / Q000097:blood; D011817:Rabbits
D006887:Hydroxycholecalciferols; D010710:Phosphates; D003404:Creatinine; D008274:Magnesium; D002118:Calcium; C008088:alfacalcidol