title: [Vitamin E and selenium-containing preparations in the prevention treatment of tetracycline-induced lesions of the liver].
abstract: Studies on albino rats showed that high doses of tetracycline-induced damages of the liver evident from increased activity of serum enzymes (alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase) and inhibition of bile secretion, synthesis and secretion of bile acids and cholesterol excretion. Administration of vitamin E, sodium selenite, infusion of Astragalus L. and especially vitamin E combinations with sodium selenite markedly or completely arrested the occurrence of hepatotoxic properties of tetracycline. It is suggested that the use of vitamin E combinations with selenium-containing preparations is advisable in the prophylaxis and treatment of tetracycline-induced damages of the liver.
mesh_terms: D000818:Animals; D001646:Bile / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury; D002751:Chlortetracycline / Q000009:adverse effects*; D004353:Drug Evaluation, Preclinical; D008099:Liver / Q000187:drug effects*; D008107:Liver Diseases / Q000188:drug therapy*; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use; D051381:Rats; D020887:Selenious Acid; D012643:Selenium / Q000627:therapeutic use*; D013752:Tetracycline / Q000009:adverse effects*; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D010936:Plant Extracts; D014810:Vitamin E; D020887:Selenious Acid; D013752:Tetracycline; D012643:Selenium; D002751:Chlortetracycline
vernacular_title: Vitamin E i selenosoderzhashchie preparaty v profilatktike i lechenii tretratsiklinovykh porazheniĭ pecheni.