[In vitro anti-fungal activity of the econazole-ornidazole combination (1:10 ratio)].
The antifungal activity of Econazole-Ornidazole combination (ratio 1:10) has been evaluated against 90 strains of Candida spp. recently isolated from a clinical environment. Minimal Inhibitory Concentrations (MICs) has been determined by a dilution broth method in test tube with Mycophil Broth (B.B.L) at pH 7.00 and drug concentrations ranging from 800 micrograms/ml to 0.2 microgram/ml. By the same technics it has been determined the pH influence of growth medium, human serum and fungal inoculum on the activity of the association towards the three strains of Candida spp.: C. albicans, C. krusei and C. tropicalis. The obtained data have shown that the Econazole-Ornidazole combination actuates a sure synergic effect towards the tested Candida strains. Such synergism is met at pH 8.00. The plasma proteins influence negatively the antifungal activity of the association proportionally to the increase of the concentration. The same thing happens with the inoculum of yeast. However, this decrease of activity of the association is always smaller than the one found in the compounds alone.
D000935:Antifungal Agents / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects*; D004338:Drug Combinations; D004357:Drug Synergism; D004464:Econazole / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D009593:Nitroimidazoles / Q000494:pharmacology*; D009950:Ornidazole / Q000494:pharmacology*
D000935:Antifungal Agents; D004338:Drug Combinations; D007093:Imidazoles; D009593:Nitroimidazoles; D009950:Ornidazole; D004464:Econazole
Attività antimicotica "in vitro" dell'associazione econazolo-ornidazolo (rapporto 1:10).