Bayesian approach to bioequivalence assessment: an example.
The statistical methods required for a Bayesian analysis of bioequivalence are outlined and numerically illustrated. The analysis consists of the calculation of the posterior probability, given the experimental results, that the ratio of true means of a new and a standard formulation of a drug with respect to some biological response lies in a given interval. Nomograms helpful for the calculation of these probabilities are provided.
D001499:Bayes Theorem; D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D008962:Models, Theoretical; D013810:Therapeutic Equivalency