Dose-dependent reduction in renal magnesium clearance by amiloride during frusemide-induced diuresis in rats.
The effects of the potassium-sparing diuretic, amiloride, on fractional magnesium excretion were investigated at four doses (0.02, 0.08, 0.20 and 2.00 mg kg-1 h-1) during frusemide-induced diuresis. Amiloride caused a dose-dependent reduction in the fractional excretion of both magnesium and potassium, whereas the effects of amiloride, over the same dose range, on fractional sodium and calcium excretion were not dose-dependent. The results indicate that amiloride exerted a specific renal action to alter magnesium and potassium transport dissociated from effects on sodium excretion.
D000584:Amiloride / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D004231:Diuresis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005665:Furosemide / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism*; D008297:Male; D011188:Potassium / Q000378:metabolism; D011719:Pyrazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000378:metabolism
D011719:Pyrazines; D000584:Amiloride; D005665:Furosemide; D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium