title: The effect of ascorbic acid on nitrite-induced methemoglobin formation in rats, sheep, and normal human erythrocytes.
abstract: Interspecies differences were demonstrated with respect to the occurrence of sodium nitrite-induced methemoglobin (METHB) in the erythrocytes of rats, dorset sheep, and normal humans, with the rats displaying approximately 25-33% of the sensitivity of sheep and human erythrocytes. Ascorbic acid incubation along with the nitrite was able to significantly reduce METHB formation in a dose-dependent manner in both rats and humans but not in sheep.
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D004347:Drug Interactions; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D005260:Female; D005978:Glutathione / Q000097:blood; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced* / Q000517:prevention & control; D009573:Nitrites / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012756:Sheep; D013045:Species Specificity
chemical_list: D009573:Nitrites; D005978:Glutathione; D001205:Ascorbic Acid