Is there a non-synaptic component in the K+-stimulated release of GABA in the developing rat cortex?
Postnatal development of the K+-stimulated release of [3H]GABA in rat cortex slices was compared to the density of Gray type 2 synapses (which correlate with GABAergic synapses in rat cortex). The [3H]GABA release system develops earlier than the inhibitory synapses which suggests that, at least in the young cortical tissue, a large part of the release mechanism is associated with other than synaptic structures.
D000375:Aging; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects*; D046508:Culture Techniques; D009433:Neural Inhibition / Q000187:drug effects; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D013569:Synapses / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D011188:Potassium; D002118:Calcium