Inherited copper toxicosis in Bedlington terriers.
Chronic hepatitis and increased hepatic copper concentrations, from 1,600 to 6,361 micrograms/g dry tissue were found in 4 related, Australian-bred Bedlington terriers. Two dogs were asymptomatic and 2 were clinically ill with signs referable to liver dysfunction. Two dogs were treated with d-penicillamine. After one year there was no improvement in the histopathological liver changes in either dog or significant lowering of hepatic copper level in one dog.
D000818:Animals; D002908:Chronic Disease; D003300:Copper / Q000378:metabolism / Q000506:poisoning*; D004283:Dog Diseases / Q000235:genetics* / Q000378:metabolism; D004285:Dogs; D005260:Female; D006505:Hepatitis / Q000235:genetics* / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008661:Metabolism, Inborn Errors / Q000235:genetics / Q000378:metabolism / Q000662:veterinary*
D003300:Copper