Cell death in the dividing pool of cells in the mouse brain.
A follow up biochemical and autoradiographic study of DNA synthesis and its retention revealed that a great part of newly synthesized DNA disappears from the brain of young adult mice within a few days. This is supposed to be mainly due to the short half-life of a majority of newly formed cells. These data provide further evidence on the redundant cell proliferation taking place in the small pool of brain cell population scattered throughout the parenchyma of the brain of young adult mice.
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000166:cytology* / Q000378:metabolism / Q000528:radiation effects; D002455:Cell Division / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects; D004247:DNA / Q000096:biosynthesis; D005260:Female; D006207:Half-Life; D007700:Kinetics; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA / Q000502:physiology*; D013936:Thymidine / Q000378:metabolism; D014316:Tritium
D014316:Tritium; D004247:DNA; D013936:Thymidine