Synthesis and pharmacological activities of some 2,3-substituted bicyclo[3.3.0]oct-7-en-1-one and 2,3-substituted 4,5,6,7-tetrahydro (or perhydro) indan-1-one derivatives.
The title compounds were synthesized and tested for primary pharmacological activities. For several hydroindanon derivatives, pharmacological screening showed diuretic, choleretic, antiinflammatory, analgesic and sedative activities.
D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis; D001643:Bridged Bicyclo Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D002756:Cholagogues and Choleretics / Q000138:chemical synthesis; D004232:Diuretics / Q000138:chemical synthesis; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis; D007189:Indans / Q000138:chemical synthesis* / Q000494:pharmacology; D007192:Indenes / Q000138:chemical synthesis*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D002756:Cholagogues and Choleretics; D004232:Diuretics; D006993:Hypnotics and Sedatives; D007189:Indans; D007192:Indenes