[Analysis of cell lines obtained from tumors induced in Syrian hamsters by SA7 adenovirus and its DNA].
Four cell lines derived from tumors induced by adenovirus SA7, its DNA (intact and fragmented with restrictase Sal-1), as well as isolated C-Sal-1 fragment (19.5% of genome) containing oncogene were studied. All the cell lines had the phenotypic markers of tumor cells, similar tumorigenicity, and produced T- and S-antigens. The line derived from the tumor induced by intact DNA contained the smallest adenovirus SA7 genome region (12%) which suggests that the information required for the synthesis of T and S antigens of adenovirus SA7 lies within the limits of this genome region.
D000256:Adenoviridae / Q000472:pathogenicity*; D000261:Adenoviruses, Simian / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D000818:Animals; D000831:Animals, Newborn; D000957:Antigens, Viral, Tumor / Q000032:analysis; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000648:ultrastructure; D002522:Chlorocebus aethiops; D006224:Cricetinae; D004279:DNA, Viral / Q000235:genetics / Q000494:pharmacology*; D005786:Gene Expression Regulation; D005814:Genes, Viral; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000209:etiology* / Q000235:genetics / Q000276:immunology; D009857:Oncogenes; D014776:Virus Cultivation
D000957:Antigens, Viral, Tumor; D004279:DNA, Viral
Analiz liniĭ kletok, poluchennykh iz opukholeĭ, indutsirovannykh u siriĭskikh khomiachkov adenovirusom SA7 i ego DNK.