Effect of tumour growth on hepatic neutral ribonuclease and its inhibitor and on RNA polymerase activity of liver nuclei.
In rats bearing a subcutaneously implanted Walker 256 carcinoma an early rise in liver DNA content was followed by a two-fold increase in RNA content between the 6th and 10th day of tumour growth. Total hepatic neutral ribonuclease and its inhibitor were unaffected by tumour growth. No alteration in RNA polymerase I and II activities of liver nuclei was observed except for a 47% increase in RNA polymerase I on the 8th day of tumour growth.
D000818:Animals; D002279:Carcinoma 256, Walker / Q000503:physiopathology*; D002455:Cell Division; D002467:Cell Nucleus / Q000201:enzymology*; D005260:Female; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D009929:Organ Size; D012318:RNA Polymerase I / Q000378:metabolism*; D012319:RNA Polymerase II / Q000378:metabolism*; D051381:Rats; D012259:Ribonuclease, Pancreatic / Q000037:antagonists & inhibitors / Q000378:metabolism*
D012319:RNA Polymerase II; D012318:RNA Polymerase I; D012259:Ribonuclease, Pancreatic