Regional distribution of histamine and tele-methylhistamine in the rat, mouse and guinea-pig brain.
Regional histamine (HA) and tele-methylhistamine (t-MH) contents were determined in the rat, mouse and guinea-pig brain. The highest HA and t-MH levels were found in the hypothalamus of all species. Fairly high t-MH levels were observed in the amygdala of all species and in the guinea-pig hippocampus. The t-MH/HA ratio was higher in the regions of the telencephalon than in the diencephalon and brainstem. The cerebellum and spinal cord showed extremely low t-MH/HA ratios. These results suggest higher histaminergic neuronal activities in the hypothalamus and some regions of the telencephalon than in other parts of the brain.
D000818:Animals; D001921:Brain / Q000473:pathology; D001923:Brain Chemistry; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000032:analysis*; D008297:Male; D008761:Methylhistamines / Q000032:analysis*; D051379:Mice; D008815:Mice, Inbred Strains; D011180:Postmortem Changes; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D014018:Tissue Distribution
D008761:Methylhistamines; D006632:Histamine; C020404:tele-methylhistamine