Studies on gliadin related peptides. I. Synthesis, purification and 1H n.m.r. characterization of the pentapeptide H-Tyr-(Gln)3-Pro-OH.
The pentapeptide H-Tyr-(Gln)3-Pro-OH has been recently postulated to be the basic repetitive unit of a sequential polypeptide contained in wheat bread alpha-gliadins, which are believed to be toxic factors in coeliac disease, gluten-dependent enteropathy. Solid-phase synthesis, purification and 1H n.m.r. characterization in water solution of this peptide are described.
D002851:Chromatography, High Pressure Liquid; D005903:Gliadin; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D009842:Oligopeptides / Q000138:chemical synthesis*; D009904:Optical Rotation; D010446:Peptide Fragments; D010940:Plant Proteins
D007202:Indicators and Reagents; D009842:Oligopeptides; D010446:Peptide Fragments; D010940:Plant Proteins; C039943:H-tyrosyl-glutaminyl-glutaminyl-glutaminyl-hydroxyproline; D005903:Gliadin