Comparative behaviour of antithrombin III antigen and antithrombin III activity in cardiovascular patients.
Antithrombin III-functional (AT III F) and immunoprotein (AT III I) assessed by two comparative methods in various cardiovascular conditions, showed significant differences between the two parameters, namely: a simultaneous decrease of both AT III F and AT III I during acute embolic episodes of only AT III F in transient ischemic attacks (with normal level of AT III I) and increase of AT III I (with apparently normal AT III F) in patient with mitral valve prosthesis. It is considered that in condition of "hypercoagulability" various patterns of AT III F/AT III I ratio can be obtained: decompensated, compensated and hypercompensated consumption.
D000328:Adult; D000368:Aged; D000941:Antigens / Q000032:analysis; D000990:Antithrombin III / Q000096:biosynthesis*; D001778:Blood Coagulation Disorders / Q000209:etiology*; D002318:Cardiovascular Diseases / Q000150:complications*; D004617:Embolism / Q000150:complications; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis; D002546:Ischemic Attack, Transient / Q000150:complications; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve; D012214:Rheumatic Heart Disease / Q000150:complications
D000941:Antigens; D000990:Antithrombin III