Donnan effect or protein interference in ionised calcium measurements?
The observation that the ionised calcium concentration is higher if measured in the original serum sample than in an ultrafiltrate is examined by means of a theoretical model. It is concluded that this difference is a predictable consequence of the Donnan equilibrium and is not a result of protein interference with the calcium-specific electrode.
D001798:Blood Proteins / Q000032:analysis*; D002118:Calcium / Q000097:blood*; D055598:Chemical Phenomena; D002621:Chemistry; D002712:Chlorides / Q000097:blood; D006801:Humans; D007477:Ions; D008956:Models, Chemical; D011485:Protein Binding; D012964:Sodium / Q000097:blood; D014462:Ultrafiltration
D001798:Blood Proteins; D002712:Chlorides; D007477:Ions; D012964:Sodium; D002118:Calcium