Pericardial injury by antibacterial irrigants.
We injected antibacterial solutions into rabbit pericardium to investigate tissue injury. Povidone-iodine was the only irrigant found to cause substantial damage. These data lend experimental support to recent clinical observations that suggest a causal relation between pericardial irrigation with povidone-iodine and the later development of constrictive pericarditis.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006965:Hyperplasia / Q000139:chemically induced / Q000473:pathology; D009355:Neomycin / Q000008:administration & dosage / Q000633:toxicity; D010496:Pericardium / Q000187:drug effects / Q000473:pathology*; D011205:Povidone / Q000031:analogs & derivatives*; D011206:Povidone-Iodine / Q000008:administration & dosage / Q000633:toxicity*; D011817:Rabbits; D007507:Therapeutic Irrigation
D011206:Povidone-Iodine; D011205:Povidone; D009355:Neomycin