Erythrocyte contents of electrolytes (Na, K, Mg, Zn) in healthy male controls and offspring to established hypertensive patients: a follow-up study.
Erythrocyte sodium, potassium, zinc and magnesium were measured in 56 male offspring to essential hypertensive patients and compared with 46 matched controls. The same parameters were measured again 4-6 months apart in 31 offspring and eight controls. Intracellular sodium was significantly higher in offspring (P less than 0.001). There was a highly significant correlation between the two intra-individual measurements of intracellular sodium, potassium and zinc but not for magnesium. Sodium in erythrocytes is probably an indicator of the activity of the sodium-pump and could possibly be used as a genetic marker in the future investigations of individuals with heredity for severe, essential hypertension.
D000293:Adolescent; D000328:Adult; D004573:Electrolytes / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D005500:Follow-Up Studies; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000235:genetics; D008274:Magnesium / Q000097:blood; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D015032:Zinc / Q000097:blood
D004573:Electrolytes; D012964:Sodium; D008274:Magnesium; D015032:Zinc; D011188:Potassium