Presenile cataracts in hydantoin-treated epileptic patients.
Two young epileptic adults developed cataracts resembling presenile diabetic lens changes, while on prolonged antiepileptic treatment with phenobarbitone and diphenylhydantoin (DPH). A research study on rats supported our view on the cataractogenic action of DPH.
D000328:Adult; D000818:Animals; D002386:Cataract / Q000139:chemically induced*; D004827:Epilepsy / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects; D010672:Phenytoin / Q000009:adverse effects*; D051381:Rats
D010672:Phenytoin; D010634:Phenobarbital