title: Clinical significance of osmotic matrix errors in automated hematology: the frequency of hyperglycemic osmotic matrix errors producing spurious macrocytosis.
abstract: Sporadic examples of spurious macrocytosis due to hyperglycemic osmotic matrix effects have been reported. The present study defines the degree of macrocytosis expected under hyperglycemic normonatremic conditions using a Coulter S + II Isoton + System and its frequency in a large inpatient and outpatient population. No examples of spurious macrocytosis due to hyperglycemia were encountered in a sample comprising 28,471 complete blood counts, of which 564 had macrocytosis.
mesh_terms: D004909:Erythrocyte Indices; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D006943:Hyperglycemia / Q000097:blood*; D008722:Methods; D009995:Osmosis; D009996:Osmotic Fragility; D011446:Prospective Studies
chemical_list: D005947:Glucose