title: Alaproclate: further pharmacological evidence for 5-HT uptake inhibition in vivo.
abstract: Alaproclate (2-/4-chlorophenyl/-1,1-dimethyl-2-amino-propanoate hydrochloride), a new selective 5-HT uptake inhibitor has been studied for its in vivo effects on the 5-HT transmission in rats in the following tests: 1) the flexor reflex in the spinal rat, 2) hyperthermia in rats at a high ambient temperature, 3) rat stomach fundus strip preparation. Alaproclate prevented potentiation of the flexor reflex in spinal rats induced by 5-HT releasers fenfluramine and p-chloroamphetamine (PCA) but did not affect the potentiation of the reflex due to direct 5-HT agonists LSD and quipazine. Also hyperthermic response of rats to fenfluramine was antagonized by alaproclate, whereas that due to quipazine was potentiated. Alaproclate failed to inhibit 5-HT-induced contractile response in rat stomach fundus strip preparation. The results confirm in vivo 5-HT uptake inhibition by alaproclate in the central nervous system, and its lack of blocking effect on postsynaptic 5-HT receptors.
mesh_terms: D000409:Alanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D002490:Central Nervous System / Q000378:metabolism*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D012018:Reflex / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism*; D013270:Stomach / Q000502:physiology
chemical_list: D011985:Receptors, Serotonin; D012701:Serotonin; C025293:alaproclate; D000409:Alanine