title: [Effect of antidepressive agents on serotonin secretion and membrane potential changes in thrombocytes].
abstract: Antidepressants  (Amitriptylin, Imipramine, Ludiomil, Alival) at the concentrations present in the blood during treatment do not inhibit serotonin secretion by human blood platelets. This also applies for the concentrations at which they are present in the blood during therapy. The same antidepressants do inhibit the changes in membrane potential accompanying serotonin secretion. This suggests that there is a weak interaction between the antidepressants and the secretion mechanism.
mesh_terms: D000928:Antidepressive Agents / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008564:Membrane Potentials / Q000187:drug effects; D012701:Serotonin / Q000097:blood*
chemical_list: D000928:Antidepressive Agents; D012701:Serotonin
vernacular_title: Der Einfluss von Antidepressiva auf Serotoninsekretion und Membranpotentialveränderungen in Thrombozyten.