Distribution of taurine in the crystalline lens of vertebrate species and in cataractogenesis.
Marked heterogeneity was observed in the distribution of taurine in different regions of the lens in various species. In general low taurine pools were observed in the nucleus of all species except frog and human. The distribution of taurine in human senile cataractous lenses at different stages of maturation showed decreased contents in all the regions except capsule epithelium as compared to the normal human lenses. This decrease is progressive upto the 'mature' stage of cataract. In rat lenses with galactose cataracts taurine contents decreased by about 83-94% of the normal values in the equatorial, anterior, posterior cortical and nuclear regions.
D000818:Animals; D002386:Cataract / Q000139:chemically induced / Q000378:metabolism*; D002645:Chickens; D005690:Galactose; D006801:Humans; D007903:Lens Capsule, Crystalline / Q000378:metabolism; D007904:Lens Cortex, Crystalline / Q000378:metabolism; D007908:Lens, Crystalline / Q000378:metabolism*; D008253:Macaca mulatta; D011817:Rabbits; D011898:Ranidae; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000378:metabolism*
D013654:Taurine; D005690:Galactose