Increased activity of serum fucosyl transferase in diabetic patients.
Serum fucosyl- (but not sialyl-) transferase activity was significantly (p less than 0.001), increased in 57 patients with diabetes mellitus. A correlation also existed in diabetics between fucosyl- (but not sialyl-) transferase activity and glycosylated serum protein (r = 0.52, p less than 0.001). Sialyl (but not fucosyl) transferase activity on the other hand correlated with hemoglobin A1 (r = 0.28, p less than 0.05). The data suggest a relationship between fucosyl/sialyl- transferase activities and long-term glucose control. Changes in these enzyme activities may affect cell membrane glycoprotein turnover which may be of importance both for insulin receptor function and later development of diabetic microangiopathy.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000201:enzymology*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000201:enzymology*; D005647:Fucosyltransferases / Q000097:blood*; D006442:Glycated Hemoglobin / Q000032:analysis; D006023:Glycoproteins / Q000378:metabolism; D006602:Hexosyltransferases / Q000097:blood*; D006801:Humans; D008875:Middle Aged; D011972:Receptor, Insulin / Q000378:metabolism; D012799:Sialyltransferases / Q000097:blood; D000093422:Glycated Serum Proteins
D001798:Blood Proteins; D005647:Fucosyltransferases; D006442:Glycated Hemoglobin; D006023:Glycoproteins; D006602:Hexosyltransferases; D011972:Receptor, Insulin; D012799:Sialyltransferases; D000093422:Glycated Serum Proteins