Drug prevention of blood-aqueous barrier disruption.
In order to evaluate the anti-inflammatory effect of non-steroidal compounds on the eye, we tested them in rabbits using the inhibitory effect on paracentesis-induced disruption of the blood-aqueous barrier. Protein and--after intravenous-injection--fluorescein were determined in punctates of aqueous humor. Indomethacin, flurbiprofen and diclofenac in a 0.01% solution showed a marked inhibitory effect, which lasted for 24 h. Addition of polysorbate to eye drugs diminished the inhibitory effect.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001082:Aqueous Humor / Q000032:analysis / Q000187:drug effects*; D001692:Biological Transport / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects*; D005123:Eye / Q000098:blood supply*; D005136:Eye Proteins / Q000032:analysis*; D011136:Polysorbates / Q000008:administration & dosage; D011817:Rabbits
D000893:Anti-Inflammatory Agents; D005136:Eye Proteins; D011136:Polysorbates