Increase of paradoxical sleep by electrical stimulation within lateral ventricles of rat.
The effect on the sleep-waking cycle of low intensity electrical stimulation (0.2 mA intensity, 80 Hz frequency, 0.7 ms signal duration) within the lateral ventricles was studied in rats maintained under a photoperiod of 12 h light and 12 h darkness (lights on at 06.00 h). When stimulation was performed at 1700 h for 3 min, there was a significant immediate increase in paradoxical sleep (PS) and slow wave sleep (SWS) during the hours of darkness, followed by a delayed increase in diurnal PS amounts during subsequent days. These results are discussed with reference to mechanisms involving the pineal gland and serotonergic system on both the immediate and long-lasting PS effects.
D000818:Animals; D002552:Cerebral Ventricles / Q000502:physiology*; D002940:Circadian Rhythm; D004558:Electric Stimulation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012895:Sleep, REM / Q000502:physiology*; D013997:Time Factors