Variant selection and blood-borne "clonogenic" tumour cells in metastasis of FSA cell clones.
Our studies of the metastatic behaviour of FSA1231 and FSA1233 show that the role of selection processes of metastatic variants at the secondary sites is minimal in the spontaneous metastasis of these systems. In contrast, tumour-cell release efficiency (number of blood-borne clonogenic tumour-cells) correlates well with the difference in spontaneous lung metastasis efficiencies of the cell clones FSA1231 and FSA1233. Also, the different tumour-cell release efficiencies could explain the discrepancy between artificial and spontaneous metastasis of these cell clones.
D000818:Animals; D002999:Clone Cells; D004247:DNA / Q000378:metabolism; D005354:Fibrosarcoma / Q000235:genetics / Q000556:secondary; D014644:Genetic Variation; D008175:Lung Neoplasms / Q000235:genetics / Q000556:secondary; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D009360:Neoplastic Cells, Circulating; D012641:Selection, Genetic
D004247:DNA