2-Chloroacetaldehyde, a metabolite of cyclophosphamide in the rat.
Following simultaneous i.v. administration of a mixture of [4-14C]cyclophosphamide (14C-CP) and [side-chain 3H]CP to rats, a metabolite containing predominantly 3H radioactivity was excreted in the urine. The 3H-labelled urinary metabolite was identified as 2-chloroacetaldehyde. Chloro[3H]acetaldehyde accounted for approx. 3.8% of urinary 3H radioactivity. The importance of chloroacetaldehyde as a toxic metabolite of CP is discussed, particularly in relation to haemorrhagic bladder disease.
D000079:Acetaldehyde / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000652:urine; D000818:Animals; D002250:Carbon Radioisotopes; D002855:Chromatography, Thin Layer; D003520:Cyclophosphamide / Q000652:urine*; D008297:Male; D010659:Phenylhydrazines; D051381:Rats; D011919:Rats, Inbred Strains; D013053:Spectrophotometry; D014316:Tritium
D002250:Carbon Radioisotopes; D010659:Phenylhydrazines; D014316:Tritium; C004787:2,4-dinitrophenylhydrazine; D003520:Cyclophosphamide; C004656:chloroacetaldehyde; D000079:Acetaldehyde