Relationship between G band number and chromosome length from prophase to metaphase.
The statistical analysis of the distribution of human chromosomes length served as a basis for their classification according to the suggestions of the Denver Conference (1960). Standards of metaphasal chromosome length were used for programmes of computer-assisted classification. The introduction of banded chromosomes in the study provided a new measurable feature which was used for classification standards accepted at the Paris Conference (1971). The measurements of these two features have been used also in the mathematical models of computer analysis and classification of chromosomes. In the present study the relationship between the number of bands and the length of chromosomes was studied in the period of cell division from prophase to metaphase in the cultures of leucocytes of healthy people. This relationship is strongly correlated and can be approximated in description to simple regression in the period from prophase to metaphase. The relationship will facilitate the construction of dynamic patterns for the needs of computer-assisted classification of chromosomes and detection of structural aberrations.
D002478:Cells, Cultured; D002871:Chromosome Banding; D002877:Chromosomes, Human / Q000145:classification / Q000648:ultrastructure*; D006801:Humans; D007621:Karyotyping; D007962:Leukocytes / Q000648:ultrastructure*; D008677:Metaphase; D011418:Prophase