Chemical modification of ravidomycin and evaluation of biological activities of its derivatives.
Several derivatives of the antitumor antibiotic ravidomycin were synthesized and their antitumor and antimicrobial activities and mode of action were evaluated. Deacylation produced a compound with higher biological activity than the parent. Structure-activity relationship of the derivatives is discussed.
D000617:Aminoglycosides / Q000138:chemical synthesis / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; C038314:ravidomycin