[Modification of sebaceous gland secretion by the antiestrogen tamoxifen in female and male golden hamsters].
24 male and 24 female syrian hamsters were treated with antiestrogen Tamoxifen for 21 days (dosage 5, 50, 200 and 800 microgram/d, respectively). For control, 6 male and 6 female animals remained untreated. After having finished this treatment, we performed double-labelling autoradiography with 3H- and 14C-thymidine on all animals, under in vivo-conditions. The number of single labelled 3H-cells has been related to cell proliferation. The quotient " double labelled cells/single 3H-labelled cells " served as a measure for the duration of the S-phase. In addition, we measured the sebaceous gland volume. No essential influence on the parameters could be found. Therefore, we have to assume that the antiestrogen Tamoxifen does not have an essential effect on cell kinetics in the sebaceous gland.
D000287:Administration, Topical; D000818:Animals; D001345:Autoradiography; D002455:Cell Division / Q000187:drug effects; D006224:Cricetinae; D005260:Female; D008297:Male; D008647:Mesocricetus; D012627:Sebaceous Glands / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D013629:Tamoxifen / Q000008:administration & dosage / Q000494:pharmacology*
D013629:Tamoxifen
Uber die Beeinflussung der Talgdrüsensekretion durch das Antiöstrogen Tamoxifen beim weiblichen und männlichen Goldhamster.