In vitro effects of pentoxifylline on hemoglobin affinity for oxygen and electrolytic equilibrium of human blood.
The in vitro effects of a pentoxifylline solution on hemoglobin-oxygen affinity and electrolytic distribution between plasma and red blood cells were evaluated. Pentoxifylline increased intracellular pH and decreased extracellular pH. There were no exchanges of Na+, K+, Ca++ and Cl- between plasma and red blood cells. Red blood cell content of 2,3-diphosphoglycerate remained unchanged, while P50 was reduced as a consequence of the intracellular alkalosis. The possible implications of the metabolic effects of pentoxifylline on red blood cell deformability and 2,3-diphosphoglycerate content in vivo are discussed.
D004573:Electrolytes / Q000097:blood*; D004910:Erythrocyte Membrane / Q000378:metabolism; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D010100:Oxygen / Q000097:blood*; D010431:Pentoxifylline / Q000494:pharmacology*; D013805:Theobromine / Q000031:analogs & derivatives*
D004573:Electrolytes; D006454:Hemoglobins; D013805:Theobromine; D010100:Oxygen; D010431:Pentoxifylline