The role of the lung in stomach carcinogenesis: a revision of the Meyer hypothesis.
Meyer et al. present an hypothesis postulating an essential opposition between lung cancer and stomach cancer based upon the interaction between cigarette smoking, respiratory impairment, and exposure to airborne carcinogens. Their theory is that respiratory impairment serves as a gate to determine whether carcinogenic airborne particulate is retained in the lungs to produce lung cancer or is cleared and swallowed to produce stomach cancer. This paper examines the foundations of the Meyer hypothesis, identifies particle deposition patterns as a crucial Meyer omission, and presents a reformulated theory based upon both particle deposition and particle retention.
D002273:Carcinogens / Q000378:metabolism*; D004391:Dust / Q000009:adverse effects; D006801:Humans; D008168:Lung / Q000378:metabolism*; D008173:Lung Diseases, Obstructive / Q000150:complications; D008175:Lung Neoplasms / Q000209:etiology* / Q000378:metabolism; D010947:Plants, Toxic; D012306:Risk; D012906:Smoke / Q000009:adverse effects; D013274:Stomach Neoplasms / Q000209:etiology* / Q000378:metabolism; D014026:Nicotiana
D002273:Carcinogens; D004391:Dust; D012906:Smoke