Studies on chemotherapy of parasitic helminths (XVIII). Mechanism of spastically paralyzing action of pyrantel in Angiostrongylus cantonensis.
Pyrantel tartrate caused spastic paralysis through stimulating nicotinic cholinoceptors in Angiostrongylus cantonensis.
D000801:Angiostrongylus / Q000502:physiology*; D000818:Animals; D005260:Female; D008681:Metastrongyloidea / Q000502:physiology*; D009068:Movement / Q000187:drug effects; D009349:Nematode Infections / Q000188:drug therapy; D011715:Pyrantel / Q000031:analogs & derivatives*; D011717:Pyrantel Tartrate / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D011978:Receptors, Nicotinic / Q000187:drug effects; D014403:Tubocurarine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D011978:Receptors, Nicotinic; D011715:Pyrantel; D005680:gamma-Aminobutyric Acid; D011717:Pyrantel Tartrate; D014403:Tubocurarine