Thallium-201: an experimental and a theoretical radiobiological approach to dosimetry.
The kinetics of uptake and retention of Tl-201, Rb-86, and K-42 and -43 have been studied in cultured mammalian cells and related to their radiotoxicities. Among the four radionuclides, the intracellular localization of Tl-201, the only emitter of Auger electrons, was important for the manifestation of its cytocidal effects. The results have been found consistent with the short-range nature of Auger electrons and are substantiated by our theoretical dosimetric calculations. The possible implications of this in vitro system for applications of Tl-201 in nuclear medicine are indicated.
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D006224:Cricetinae; D003412:Cricetulus; D005347:Fibroblasts; D007700:Kinetics; D008168:Lung; D008962:Models, Theoretical; D010042:Ouabain / Q000494:pharmacology; D011197:Potassium Radioisotopes / Q000378:metabolism; D011789:Quantum Theory; D011829:Radiation Dosage; D011868:Radioisotopes / Q000378:metabolism*; D012413:Rubidium / Q000378:metabolism; D013696:Temperature; D013793:Thallium / Q000378:metabolism*
D011197:Potassium Radioisotopes; D011868:Radioisotopes; D010042:Ouabain; D013793:Thallium; D012413:Rubidium