High-performance liquid chromatographic stability-indicating assay for naphazoline and tetrahydrozoline in ophthalmic preparations.
A high-performance liquid chromatographic (HPLC) analysis for tetrahydrozoline and naphazoline in ophthalmic solutions is presented. The analysis allows a more reproducible, direct stability-indicating assay than the colorimetric methods generally employed. The HPLC system is so designed that a variety of ophthalmic solutions containing either naphazoline or tetrahydrozoline can be analyzed concomitantly.
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D007093:Imidazoles / Q000032:analysis*; D009278:Naphazoline / Q000032:analysis*; D009883:Ophthalmic Solutions / Q000032:analysis
D007093:Imidazoles; D009883:Ophthalmic Solutions; D009278:Naphazoline; C005810:tetrahydrozoline