[Experimental and clinical evaluation of an ampicillin suppository (KS-R1)].
The basic and clinical studies of ampicillin suppository (KS-R1) in pediatric infections were carried out, and the following results were obtained: For study of absorption and excretion of KS-R1, a single dose of 250 mg of KS-R1 was administered to 3 cases. The mean serum levels were obtained 4.10 +/- 1.55 micrograms/ml at 30 minutes, and 1.52 +/- 0.25 micrograms/ml, 0.38 +/- 0.04 micrograms/ml at 1 and 2 hours after rectal administration, respectively. The serum levels were not detectable after 4 hours in all cases. The half lives were 0.39, 0.54 hour and 0.44 hour, respectively. The mean urinary excretion rate to 6 hours was 14.8%. Clinical efficacy was evaluated in 17 cases with tonsillitis (15 cases), bronchitis (1 case) and scarlet fever (1 case). Good responses were obtained in 15 of 17 cases (88.2%). Bacteriological response in the form of eradication was noted in 4 of 5 cases. Side effects were examined with all of the 19 cases, and eosinophilia was observed in 1 case.
D000367:Age Factors; D000667:Ampicillin / Q000008:administration & dosage* / Q000009:adverse effects / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D013488:Suppositories
D013488:Suppositories; D000667:Ampicillin