title: Chemical modification of ravidomycin and evaluation of biological activities of its derivatives.
abstract: Several derivatives of the antitumor antibiotic ravidomycin were synthesized and their antitumor and antimicrobial activities and mode of action were evaluated. Deacylation produced a compound with higher biological activity than the parent. Structure-activity relationship of the derivatives is discussed.
mesh_terms: D000617:Aminoglycosides / Q000138:chemical synthesis / Q000627:therapeutic use / Q000633:toxicity; D000818:Animals; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; C038314:ravidomycin