title: Short term toxicity study in rats dosed with peppermint oil.
abstract: Peppermint oil was given p.o. to groups of 10 male and 10 female rats at dosage levels of 0, 10, 40 and 100 mg/kg bw/day respectively for 28 days. Histopathological changes in the white matter of the cerebellum especially were seen at dose levels of 40 and 100 mg/kg bw/day and consisted of cyst-like spaces scattered in the white matter. There were no obvious signs of clinical symptoms due to the encephalopathy.
mesh_terms: D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced; D002531:Cerebellum / Q000473:pathology*; D005260:Female; D008297:Male; D036142:Mentha piperita; D009822:Oils, Volatile / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000633:toxicity*; D010938:Plant Oils; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D009822:Oils, Volatile; D010936:Plant Extracts; D010938:Plant Oils; C015424:peppermint oil