Cholera toxin genes: nucleotide sequence, deletion analysis and vaccine development.
Nucleotide sequence and deletion analysis have been used to identify the regulatory and coding sequences comprising the cholera toxin operon (ctx). Incorporation of defined in vitro-generated ctx deletion mutations into Vibrio cholerae by in vivo genetic recombination produced strains which have practical value in cholera vaccine development.
D001483:Base Sequence; D002772:Cholera Toxin / Q000235:genetics*; D022121:Cholera Vaccines; D003001:Cloning, Molecular; D005786:Gene Expression Regulation; D009876:Operon; D011995:Recombination, Genetic; D014734:Vibrio cholerae / Q000235:genetics
D022121:Cholera Vaccines; D002772:Cholera Toxin