Long-lived oxidants generated by human neutrophils: characterization and bioactivity.
Human neutrophils were found to generate an unusual class of oxidants with a half-life of approximately 18 hours and with characteristics similar to, if not identical with, those of N-chloroamines. These neutrophil-derived N-chloroamines have sufficient oxidizing potential to attack sulfhydryl- or thioether-containing compounds and can react with both a methionine-containing chemotactic peptide and a plasma protease inhibitor. As judged by their stability and selective reactivity, the N-chloroamines generated by stimulated neutrophils may play an important role in the local and systemic regulation of inflammatory events in vivo.
D002630:Chemotactic Factors / Q000378:metabolism; D002700:Chloramines / Q000502:physiology*; D006801:Humans; D008715:Methionine / Q000378:metabolism; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000378:metabolism; D009504:Neutrophils / Q000502:physiology*; D010084:Oxidation-Reduction; D011480:Protease Inhibitors / Q000378:metabolism
D002630:Chemotactic Factors; D002700:Chloramines; D011480:Protease Inhibitors; D009240:N-Formylmethionine Leucyl-Phenylalanine; D008715:Methionine