[Acute thrombosis of the aortic bifurcation caused by heparin allergy. Apropos of 5 cases].
Five patients with humoral intolerance to heparin developed acute thromboses, with a fatal outcome in two cases from failure to establish the diagnosis, marked sequelae in one case, and recovery without complications in the other two. Accidents of this type may occur in 0.6 p. cent of patients on heparin therapy and are almost always fatal if administration is not discontinued. They result from a severe immunoallergic. Thrombocytopenia which may lead to the formation of arterial clots. Arterial thrombosis during heparin therapy is suggestive of the diagnosis and tests for diminished platelet counts are necessary. Apart from surgery, treatment involves the immediate cessation of heparin therapy.
D000208:Acute Disease; D000368:Aged; D001018:Aortic Diseases / Q000139:chemically induced* / Q000628:therapy; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006493:Heparin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011379:Prognosis; D013927:Thrombosis / Q000139:chemically induced* / Q000628:therapy
D006493:Heparin
Les thromboses aiguës du carrefour aortique par allergie à l'héparine. A propos de 5 observations.