Brain biogenic amines and pituitary-adrenocortical function in the rat.
Treatment of rats with various doses of the monoamine oxidase inhibitor (MAOI) pargyline failed to alter plasma levels of corticosterone at 18 hours post-dosage even though brain levels of serotonin and norepinephrine were increased by 51 to 95 percent. Single pargyline doses of 17.5 or 25 mg/kg blocked the increased plasma corticosterone response to reserpine. Animals pretreated with two doses of the MAOI showed a time-dependent sedative response to reserpine. In these animals, the plasma corticosterone response to reserpine was blocked, while the responses to cold exposure or chlorpromazine were unaffected.
D000302:Adrenal Cortex / Q000502:physiology; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002746:Chlorpromazine / Q000494:pharmacology; D003080:Cold Temperature; D003345:Corticosterone / Q000097:blood; D004347:Drug Interactions; D009638:Norepinephrine / Q000378:metabolism*; D010293:Pargyline / Q000494:pharmacology*; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D012701:Serotonin / Q000378:metabolism*
D012701:Serotonin; D012110:Reserpine; D010293:Pargyline; D002746:Chlorpromazine; D003345:Corticosterone; D009638:Norepinephrine