title: Short course netilmicin prophylaxis in renal stone surgery.
abstract: Following surgery for the removal of intrarenal calculi 30% of patients will develop severe wound complications. This study assesses the role of a short course of netilmicin given over the operative period, in 20 consecutive patients. Preoperative studies demonstrated that whilst 20% of patients had bacterial growth in the urine, culture of the removed calculus demonstrated that 50% of the stones exhibited a significant bacterial growth. Of the 20 patients, only one developed a wound complication. Following the preoperative dose, satisfactory netilmicin levels were obtained and no patient had levels greater than 1 microgram ml-1 by 7 h. Despite some degree of renal impairment, serum urea and creatinine values were unaffected.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D007669:Kidney Calculi / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009428:Netilmicin / Q000627:therapeutic use*; D011292:Premedication; D013530:Surgical Wound Infection / Q000517:prevention & control; D014552:Urinary Tract Infections / Q000517:prevention & control
chemical_list: D005839:Gentamicins; D009428:Netilmicin