[Embryotoxic and mutagenic activity of ethanol and acetaldehyde in intra-amniotic exposure].
The administration of acetaldehyde on the 13th day of pregnancy results in a considerable embryolethal effect, appearance of developmental abnormalities in rat embryos and chromosomal aberrations in fetal cells. Ethanol is found to have no teratogenic and mutagenic activity.
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology; D000079:Acetaldehyde / Q000633:toxicity*; D000650:Amnion / Q000187:drug effects*; D000818:Animals; D002875:Chromosomes / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D020964:Embryo Loss / Q000139:chemically induced; D004622:Embryo, Mammalian / Q000187:drug effects*; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D007267:Injections / Q000379:methods; D009153:Mutagens / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D009153:Mutagens; D000431:Ethanol; D000079:Acetaldehyde
Embriotoksicheskaia i mutagennaia aktivnost' étanola i atsetal'degida pri vnutriamnioticheskom vozdeĭstvii.