[Glutathione--an essential component of radio-modifying action of serotonin].
5-HT applied prior to, immediately or 5 min after irradiation decreased equally the radiation damage to Ehrlich ascite tumor cells. A decrease in the endogenous glutathione content by N-ethylmaleimide (NEM) led to reduced the 5-HT radio-modifying effect. Its radio-modifying effect decreased irrespective of whether NEM was applied prior to or after irradiation.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism* / Q000532:radiotherapy; D002478:Cells, Cultured; D005978:Glutathione / Q000378:metabolism*; D051379:Mice; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D012701:Serotonin / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000378:metabolism
D011837:Radiation-Protective Agents; D013438:Sulfhydryl Compounds; D012701:Serotonin; D005978:Glutathione
Gliutation--neobkhodimyĭ komponent radiomodifitsiruiushchego deĭstviia serotonina.