Antidiabetic activity of some 1-substituted 3,5-dimethylpyrazoles.
Several new 1-substituted 3,5-dimethylpyrazoles were prepared for testing as hypoglycemic agents. A number of these containing para-substituted 1-carbonylphenylurea and para-substituted 1-carbamoylbenzenesulfonylurea derivatives were found to possess potent hypoglycemic activity.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D005260:Female; D007004:Hypoglycemic Agents / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007202:Indicators and Reagents; D011720:Pyrazoles