[1-Desaminopenicillamine, 8-alpha-hydroxyisocaproic acid] oxytocin. A selective inhibitor in rats of the uterine response to oxytocin.
[1-Desaminopenicillamine, 8-alpha-hydroxyisocaproic acid] oxytocin was synthesized by a 6 + 3 fragment condensation from precursors which had been formed by solution methods. This analog inhibited uterine responses to oxytocin (pA2 7.37, 7.9, 6.17; uterus in vitro without Mg++, in vitro with Mg++, and in vivo, respectively) and showed little or no activity in other bioassays.
D000595:Amino Acid Sequence; D000818:Animals; D001681:Biological Assay; D005260:Female; D007202:Indicators and Reagents; D008274:Magnesium / Q000494:pharmacology; D008893:Milk Ejection / Q000187:drug effects; D010121:Oxytocin / Q000037:antagonists & inhibitors*; D011247:Pregnancy; D051381:Rats; D013329:Structure-Activity Relationship; D014590:Uterine Contraction / Q000187:drug effects*
D007202:Indicators and Reagents; D010121:Oxytocin; D008274:Magnesium