Criticism of pharmacokinetic clearance concepts.
The value of pharmacokinetic parameters is confirmed by clinical impacts. Drug dosage recommendations are usually derived from the one-compartment model and linear first-order kinetics. These are described by the parameters bioavailability, volume of distribution, and elimination half-life. Thus, elimination half-life and volume of distribution are the most important clinical pharmacokinetic parameters and the one-compartment model is the most universal pharmacokinetic concept. Drug clearance provides no further information. To evaluate drug clearance, the AUC must be extrapolated. This requires the assumption of a compartment model. The intrinsic hepatic clearance cannot be equated with hepatic metabolism capacity. Therefore, drug clearance does not appear to be a superior pharmacokinetic parameter.
D001682:Biological Availability; D005069:Evaluation Studies as Topic; D006207:Half-Life; D006801:Humans; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008657:Metabolic Clearance Rate; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000378:metabolism*
D004364:Pharmaceutical Preparations