The effects of midazolam in conjunction with alcohol on iconic memory and free-recall.
The effects of midazolam 15 mg and alcohol 0.5 g/kg on short-term storage in the visual system (iconic memory) and free recall of a word list were investigated in 8 normal volunteers. Acute doses of midazolam, alcohol and midazolam in combination with alcohol were all found to decrease iconic memory whereas only midazolam and midazolam + alcohol impaired immediate recall. Anterograde amnesia was observed following treatment with midazolam and midazolam in conjunction with alcohol. The results suggest a potentiation of the effects of midazolam, on aspects of human memory by the co-administration of small doses of alcohol.
D000328:Adult; D000647:Amnesia / Q000139:chemically induced; D001569:Benzodiazepines / Q000008:administration & dosage*; D004357:Drug Synergism; D000431:Ethanol / Q000008:administration & dosage*; D006801:Humans; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects; D008874:Midazolam; D014796:Visual Perception / Q000187:drug effects
D001569:Benzodiazepines; D000431:Ethanol; D008874:Midazolam