Aminopyrine breath test predicts surgical risk for patients with liver disease.
To determine whether the [14C] aminopyrine breath test (ABT) predicts surgical risk in patients with liver disease, it was obtained prior to various surgeries in 38 patients with known or suspected liver disease. A modified Child's classification was also determined. Six of the seven operative deaths (three Child's A, two B, two C) had ABTs less than 2.3%, while 30 of 31 survivors (24 Child's A, seven B) had ABTs greater than 2.3% (p less than 0.000018). Seven of the 16 patients with normal ABTs had biopsy-proven cirrhosis and had postoperative courses indistinguishable from the remainder of the group. We conclude that surgery in patients with ABTs less than 2.3% is associated with extremely high mortality. In addition, cirrhotics with normal ABTs tolerate elective surgery well.
D000328:Adult; D000368:Aged; D000632:Aminopyrine; D001944:Breath Tests; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000401:mortality / Q000503:physiopathology / Q000601:surgery*; D008108:Liver Diseases, Alcoholic / Q000401:mortality / Q000503:physiopathology / Q000601:surgery; D008111:Liver Function Tests / Q000379:methods; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011379:Prognosis; D012306:Risk
D000632:Aminopyrine