The effect of jaundiced sera and bile salts on cultured beating rat heart cells.
Jaundiced serum from common bile duct ligated rats, added to cultured heart cells, decreased the beating rate, caused an early cessation of beating and production of higher levels of lactate in the media. Deoxycholate and cholate are the main bile acids in jaundiced serum; deoxycholate caused similar effects, which suggests that it is the toxic substance responsible for heart function alterations seen in patients with severe jaundice.
D000818:Animals; D001647:Bile Acids and Salts / Q000097:blood / Q000494:pharmacology*; D002478:Cells, Cultured; D002779:Cholestasis / Q000097:blood*; D002793:Cholic Acids / Q000494:pharmacology; D003135:Common Bile Duct / Q000502:physiology; D003840:Deoxycholic Acid / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects*; D008026:Ligation; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D001647:Bile Acids and Salts; D002793:Cholic Acids; D003840:Deoxycholic Acid