[Age variations in ethylmorphine demethylase and benzopyrene hydroxylase activities in rat liver microsomes].
The ethylmorphine demethylase activity of the rat liver microsomes was higher in three-month animals (as compared to one-month), remained at a high level in the 12-month and decreased in old rats. The benzopyrene hydrolase activity increased in three-month animals, decreased in 12-month rats and remained the same with subsequent ageing of the organism. Asynchronicity of variations in the oxidation rate of different xenobiotics with ageing is considered as a result of changes in substrate specificity of the monooxygenase system due to metabolic peculiarities which reflect the age development of the organism and extinction of the reproduction function.
D000375:Aging; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D001579:Benzopyrene Hydroxylase / Q000378:metabolism*; D005037:Ethylmorphine-N-Demethylase / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000254:growth & development*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism*; D051381:Rats
D001579:Benzopyrene Hydroxylase; D001189:Aryl Hydrocarbon Hydroxylases; D010089:Oxidoreductases, N-Demethylating; D005037:Ethylmorphine-N-Demethylase
Vozrastnye izmeneniia étilmorfindemetilaznoĭ i benzpirengidroksilaznoĭ aktivnosteĭ mikrosom pecheni krys.