[Endomorphins and experimental analgesic action of amitriptyline].
The analgesic effect of several doses of amitriptyline was studied in rats. The lower doses of the tricyclic compound showed clear analgesic properties whereas the higher doses remained ineffective. Naloxone, deprived of effect when administered alone, reduced the antinociceptive action of amitriptyline. These results suggest that the analgesic properties of the tricyclic compound could involve endorphin central systems.
D000639:Amitriptyline / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004723:Endorphins / Q000494:pharmacology*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D009619:Nociceptors / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000700:Analgesics; D004723:Endorphins; D000639:Amitriptyline; D009270:Naloxone
Endomorphines et action analgésique expérimentale de l'amitriptyline.