title: Gossypol. Synthesis and in vitro spermicidal activity of isomeric hemigossypol derivatives.
abstract: Three isomeric hemigossypol derivatives (3,4,5) have been synthesized. Two of these derivatives (3,4) and one synthetic intermediate (7) have been shown to have activity comparable to gossypol (1) in a sperm motility assay.
mesh_terms: D000818:Animals; D006224:Cricetinae; D006072:Gossypol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D007536:Isomerism; D008297:Male; D013081:Sperm Motility / Q000187:drug effects*
chemical_list: D006072:Gossypol