title: Hypothesis: control of hepatic utilization of alanine by membrane transport or by cellular metabolism? Review.
abstract: The rate of alanine transport into the liver limits its utilization even under the high alanine load resulting from a 90% casein diet, given that the rat has been adapted to that diet. A coordinated acceleration of alanine catabolism allows transport to remain rate-limiting, which in turn allows the adaptive regulation of transport to remain effective at high alanine loads. Accelerated degradation of alanine may change the hepatic amino acid content in a way that derepresses the activity of the alanine carrier system(s).
mesh_terms: D000409:Alanine / Q000378:metabolism*; D000410:Alanine Transaminase / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D002364:Caseins / Q000378:metabolism; D004044:Dietary Proteins / Q000378:metabolism; D005246:Feedback; D005508:Food Deprivation; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000378:metabolism; D008297:Male; D051381:Rats
chemical_list: D000596:Amino Acids; D002364:Caseins; D004044:Dietary Proteins; D000410:Alanine Transaminase; D000409:Alanine