Synthetic progestins and sweetness preference in intact female Sprague-Dawley rats.
Intact Sprague-Dawley female rats were treated with 0.25 microgram or 1.25 micrograms ethinyl-estradiol (EE) in combination with one of 3 synthetic progestins: (5 micrograms) norethindrone, norethynodrel, or norgestrel. In Experiment 1 both dosages of EE in combination with the synthetic progestins suppressed sweetness preference, with a somewhat greater effect for the 1.25 micrograms EE dosage. Norgestrel in combination with EE produced the longest suppression of sweetness preference. In Experiment 2 progestins administered in the absence of EE showed no significant effect on sweetness preference. When 1.25 micrograms EE was administered singularly, a significant decline in sweetness preference occurred, but not as great a decline as in combination with a progestin.
D000704:Analysis of Variance; D000818:Animals; D004326:Drinking / Q000187:drug effects; D005260:Female; D009640:Norethindrone / Q000494:pharmacology*; D009641:Norethynodrel / Q000494:pharmacology*; D009644:Norgestrel / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012439:Saccharin; D012996:Solutions; D013649:Taste / Q000502:physiology*
D012996:Solutions; D009644:Norgestrel; D009641:Norethynodrel; D012439:Saccharin; D009640:Norethindrone