'Insulin-like' effects of lithium ion on isolated rat adipocytes. I. Stimulation of glycogenesis beyond glucose transport.
Both insulin and lithium ion stimulated cytochalasin B-sensitive glucose transport in isolated rat adipocytes. As a result of enhanced glucose transport, the incorporation of [14C]glucose into CO2, glycogen and lipid were increased by both agents. However, the action of these two agents was distinguished. Cytochalasin B decreased insulin-stimulated glucose oxidation, glycogenesis and lipogenesis. In contrast, lithium-stimulated glycogenesis was decreased but lithium-stimulated glucose oxidation and lipogenesis were completely blocked. These results indicate that lithium ion in rat adipocytes has a specific insulin-like effect on glycogenesis without affecting glucose oxidation and lipogenesis.
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D003571:Cytochalasin B / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000096:biosynthesis*; D066298:In Vitro Techniques; D008094:Lithium / Q000494:pharmacology*; D051381:Rats
D003571:Cytochalasin B; D006003:Glycogen; D008094:Lithium; D005947:Glucose