[6-week intravenous toxicity test of cefpiramide in rhesus monkeys].
A subchronic toxicity of cefpiramide (CPM) was studied in rhesus monkeys. The drug was administered intravenously to 4 groups of 2 males and 2 females each at a daily dose of 0, 100, 300 mg/kg and 1,000 mg/kg, respectively, for 6 weeks. Vomiting and diarrhea were observed at every dose of CPM, more frequently at the beginning of the treatment period. In addition, salivation was observed at 300 mg/kg or more and a transient subdued mood and inappetence at 1,000 mg/kg. A slight decrease of body weight was noted in a female given 1,000 mg/kg. There were no treatment-related changes in fecal occult blood test and electrocardiograms. Ophthalmological examinations showed no abnormalities being attributable to the treatment. A transient or slight anemia was observed in 2 monkeys receiving 1,000 mg/kg. Examination of bone marrow revealed no abnormalities. There were no effects on plasma biochemical parameters. In urinalysis, a female in the 1,000 mg/kg group showed a glycosuria. Kidneys of 3 animals given 1,000 mg/kg were pale at necropsy. Liver and kidneys were heavier in some animals at 300 mg/kg or more and at 1,000 mg/kg, respectively. Histological examination revealed a multifocal degeneration and regeneration of the proximal renal tubular epithelium in all animals receiving 1,000 mg/kg. No treatment-related changes were encountered in other organs and tissues. From these results, the maximum non-effective dose level of CPM was considered to be 300 mg/kg.
D000818:Animals; D001769:Blood / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001854:Bone Marrow Cells; D002511:Cephalosporins / Q000633:toxicity*; D003967:Diarrhea / Q000139:chemically induced; D005123:Eye / Q000187:drug effects; D005260:Female; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008253:Macaca mulatta; D008297:Male; D009929:Organ Size / Q000187:drug effects; D014839:Vomiting / Q000139:chemically induced
D002511:Cephalosporins; C036666:cefpiramide