[Tert-aminoalkyl derivatives of 3-methyl-6,8-diazaquinoxaline-2(1H)-ones. Effect on the acquisition and modification of a conditioned avoidance response in rats].
By condensating ethyl pyruvate with 4-dialkylaminoalkyl-5-aminopyrimidine, obtained by hydrogenolysis of the corresponding 6-chloroderivatives, were prepared 3-methyl-6,8-diazaquinoxalinee-2(1H)-ones which carry on position 1 a tert-aminoalkyl chain (dimethylaminoethyl-, morpholinylethyl-, dimethylaminopropyl- and N-methylpiperazinylpropyl-). The synthetized compounds were tested to verify the effects on acquisition and modification of a conditioned avoidance response (C.A.R.) in rats. In these tests 1-dimethylaminoethyl-3-methyl-6,8-diazaquinoxalin-2(1H)-one, shows activity comparable with that of the cloropromazine.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D011810:Quinoxalines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D011810:Quinoxalines; D002746:Chlorpromazine
Terz-amminoalchilderivati di 3-metil-6,8-diazachinossalin-2(1H)-oni. Effetto sull'acquisizione e sulla modificazione di una risposta condizionata di "avoidance" nel ratto.