Opioid peptides. Analgesic activity of potent dermorphin tetrapeptides. VI.
By employing the mouse tail-flick assay the analgesic activity of selected dermorphin tetrapeptides was assessed. The remarkable differences in potency exhibited by peptides after i.c.v. (500-1000 times higher than morphine) and s.c. (nearly comparable to morphine) administration are probably due to peptidase degradation.
D000700:Analgesics / Q000138:chemical synthesis*; D000818:Animals; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D051379:Mice; D009020:Morphine / Q000494:pharmacology; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D018847:Opioid Peptides; D011930:Reaction Time / Q000187:drug effects; D013997:Time Factors
D000700:Analgesics; D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin; D009020:Morphine