Acute polyarthritis following the use of Corynebacterium parvum vaccine (Coparvax) for malignant pleural effusion.
A 77-year-old man with a malignant pleural effusion was treated by aspiration of fluid and injection of Corynebacterium parvum vaccine for pleurodesis. Within 24 hr he had developed a temperature and a neutropenia followed by an acute crippling polyarthritis of his hands and wrists which subsequently responded to oral steroids and non-steroidal antiinflammatory drugs.
D000208:Acute Disease; D000368:Aged; D001168:Arthritis / Q000209:etiology*; D001428:Bacterial Vaccines / Q000009:adverse effects*; D002294:Carcinoma, Squamous Cell / Q000628:therapy; D006801:Humans; D008297:Male; D010996:Pleural Effusion; D010997:Pleural Neoplasms / Q000628:therapy; D011425:Propionibacterium acnes / Q000276:immunology*
D001428:Bacterial Vaccines