Mucosal damage following electrical stimulation of the anterior cingulate cortex and pretreatment with atropine and cimetidine.
Bipolar electrical stimulation of a restricted area of the anterior cingulate cortex in anesthetized rats produced stomach erosions. Pretreatment with atropine sulfate prevented the pathological effects of stimulation. Cimetidine was not effective in preventing the gastric damage. It was concluded that the pathological effects of electrical stimulation were cholinergically mediated, whereas, histamine-2 receptors were not involved.
D000818:Animals; D001285:Atropine / Q000627:therapeutic use*; D001931:Brain Mapping; D002927:Cimetidine / Q000627:therapeutic use*; D004558:Electric Stimulation; D005753:Gastric Mucosa; D006179:Gyrus Cinguli / Q000502:physiology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013272:Stomach Diseases / Q000209:etiology / Q000517:prevention & control; D013276:Stomach Ulcer / Q000517:prevention & control
D001285:Atropine; D002927:Cimetidine