title: Fragile chromosome 16(q22) cause a balanced translocation at the same point.
abstract: A father with a fragile 16(q22) has a son with a de novo balanced translocation 1;16. Both the fragile site and the break point at chromosome 16 are similar (q22). The question of whether the fragile site can cause a structural chromosome abnormality at the same point is discussed.
mesh_terms: D000328:Adult; D002648:Child; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002902:Chromosomes, Human, 16-18; D006801:Humans; D007621:Karyotyping; D008297:Male; D014178:Translocation, Genetic