Control of schistosomiasis in Adwa, Ethiopia, using the plant molluscicide endod (Phytolacca dodecandra).
Control of Schistosoma mansoni transmission in a town in northern Ethiopia was attempted using the natural product, endod (Phytolacca dodecandra), and its use compared with niclosamide. Within a five year period prevalence was reduced from 61.5 to 36.4% in the area where endod was used. Most of this decline was accounted for by the reduction in prevalence among 1-6 year old subjects. The practical use of endod as a molluscicide was demonstrated to have a performance which compared favourably with the commercial product, and although more expensive than niclosamide still at minimal annual cost (US + 0.06 per capita).
D000818:Animals; D001700:Biomphalaria / Q000469:parasitology*; D002648:Child; D002675:Child, Preschool; D002835:Christianity; D005002:Ethiopia; D005260:Female; D005618:Fresh Water; D006801:Humans; D007223:Infant; D007514:Islam; D008297:Male; D009534:Niclosamide / Q000494:pharmacology; D029605:Phytolacca dodecandra; D010936:Plant Extracts / Q000494:pharmacology*; D010947:Plants, Toxic; D012550:Schistosoma mansoni / Q000302:isolation & purification; D012552:Schistosomiasis / Q000453:epidemiology / Q000517:prevention & control* / Q000635:transmission; D012737:Sex Factors; D014504:Urban Health; D014881:Water Supply
C007592:Phytolacca dodecandra extract; D010936:Plant Extracts; D009534:Niclosamide