Effect of secondary hyperparathyroidism on the anaemia of end-stage renal failure: in vivo and in vitro studies.
Changes in haematocrit of 29 haemodialysis patients were followed 12 months before, close to and 12 months after parathyroidectomy. Mean haematocrit decreased significantly from 31.6 +/- 8.6 per cent to 29.1 +/- 8.4 per cent and increased to 33.3 +/- 7.9 per cent after PTX. Serum erythropoietin concentration, investigated pre and 6-12 months post PTX, at a time, when an increase of haematocrit values had been observed, did not significantly change (63 +/- 58 vs 67 +/- 37 mU/ml). The effect of 1-84 bovine parathyroid hormone on erythropoiesis was studied in vitro. A dose-related inhibition of colony formation of both fetal mouse liver and human bone marrow erythroid cells was observed in the presence of two to 8U parathyroid hormone/ml, suggesting direct bone marrow toxicity by excessive parathyroid hormone concentrations.
D000740:Anemia / Q000097:blood / Q000209:etiology*; D004920:Erythropoiesis / Q000187:drug effects; D006400:Hematocrit; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000150:complications* / Q000601:surgery; D066298:In Vitro Techniques; D007676:Kidney Failure, Chronic / Q000150:complications*; D010281:Parathyroid Hormone / Q000494:pharmacology
D010281:Parathyroid Hormone