The influence of paracetamol on the anti-inflammatory, the anti-pyretic and the analgesic activity of indomethacin.
Interactions between indomethacin (INDO) and paracetamol (PAR) with regard to their anti-inflammatory, anti-pyretic and analgesic activities were studied in rats. The anti-inflammatory and anti-pyretic effects of INDO and PAR were additive. Although antagonism was observed in the analgesic test, the effect of the combination was not inferior to that of PAR alone.
D000082:Acetaminophen / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D004347:Drug Interactions; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D010146:Pain / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012684:Sensory Thresholds / Q000187:drug effects
D004338:Drug Combinations; D000082:Acetaminophen; D007213:Indomethacin