Antimetastatic effects of maleic anhydride-divinyl ether in rats with mammary adenocarcinoma.
Effects of maleic anhydride-divinyl ether (MVE-2) on lymph node and lung metastases were studied in rats transplanted with a syngeneic mammary adenocarcinoma. Subcutaneous treatment with MVE-2 was administered according to various schedules, with or without surgical removal of the primary tumor. A significant reduction in size and/or incidence of lymph node metastases was observed, although no effect on the primary tumor was noted. Histologic evidence of degeneration of metastatic tumor cells, which were surrounded by lymphocytes and a characteristic focal histiocytosis, was present in the regional lymph nodes. The number of lung metastases resulting from iv injection of tumor cells was also significantly reduced following iv injection of MVE-2.
D000818:Animals; D005260:Female; D008175:Lung Neoplasms / Q000556:secondary; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis / Q000517:prevention & control; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy*; D009362:Neoplasm Metastasis / Q000517:prevention & control*; D011108:Polymers / Q000627:therapeutic use*; D011713:Pyran Copolymer / Q000627:therapeutic use*; D051381:Rats
D011108:Polymers; D011713:Pyran Copolymer