Cytoprotecting-effect of cimetidine: experimental evidence in the rat gastric mucosal lesions induced by intragastric administration of necrotizing agents.
Contradictory data have been found on cimetidine-induced gastric cytoprotection. In our paper the effect of cimetidine administered intraperitoneally in doses of 2.5, 10 and 50 mg X kg-1, on: 1. The gastric acid secretory responses in 1 and 4 hr pylorus-ligated rats, and 2. The rat gastric mucosal lesions induced by intragastric administration of 0.6 M HCl, 0.2 M NaOH, 96% ethanol and 25% NaCl is discussed. It was found that: 1. Cimetidine dose-dependently inhibited the gastric acid secretion in 1 and 4 hr pylorus-ligated rats, but a dose of 2.5 mg X kg-1 did not exert any significant inhibition; 2. All doses of cimetidine significantly prevented the gastric lesion development induced by different necrotizing agents (0.6 M HCl, 0.2 M NaOH, 96% ethanol, and 25% NaCl); 3. The cytoprotecting dose of cimetidine was of 2.5 mg X kg-1; and 4. The duration of cimetidine-induced cytoprotection was 1 hr long before the administration of the necrotizing agent. These results suggest a real cimetidine-induced gastric cytoprotection.
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D000431:Ethanol / Q000633:toxicity; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000473:pathology*; D006851:Hydrochloric Acid / Q000633:toxicity; D008297:Male; D051381:Rats; D012965:Sodium Chloride / Q000633:toxicity; D012972:Sodium Hydroxide / Q000633:toxicity; D013272:Stomach Diseases / Q000517:prevention & control*
D000431:Ethanol; D012965:Sodium Chloride; D012972:Sodium Hydroxide; D002927:Cimetidine; D006851:Hydrochloric Acid