Enhancement of the stimulating effect of fructose-1.6-diphosphate on the metabolic energy balance of carbohydrate-deficient bovine lenses by additional supply with ADP.
The energy supply in carbohydrate-deficient bovine lenses was disturbed, as could be demonstrated by measuring the content of free adenine nucleotides. It could be regenerated in part by a 3-hour-incubation in TCM 199 in the presence of fructose-1.6-diphosphate (FDP). Additional supply of ADP enhanced the stimulating effect of FDP towards formation of ATP, providing sufficient receptor molecules for the activated rate of glycolysis and probably also for the citric acid cycle.
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D050260:Carbohydrate Metabolism; D002417:Cattle; D004734:Energy Metabolism / Q000187:drug effects*; D005635:Fructosediphosphates / Q000494:pharmacology*; D006019:Glycolysis / Q000187:drug effects; D006598:Hexosediphosphates / Q000494:pharmacology*; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D007908:Lens, Crystalline / Q000187:drug effects* / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid
D005635:Fructosediphosphates; D006598:Hexosediphosphates; D007773:Lactates; D011773:Pyruvates; D019344:Lactic Acid; D000244:Adenosine Diphosphate; D019289:Pyruvic Acid; D000255:Adenosine Triphosphate; C029063:fructose-1,6-diphosphate