[Effect of the treatment of psoriasis with dithranol in comparison with a combination of dithranol and a corticosteroid].
Symmetric lesions of ten psoriasis patients were treated with anthralin and a combination of anthralin and steroid to compare the effect of these two therapies. After treatment, tissue was excised from the papules. An in vitro double-labeling autoradiography with 3H- and 14C-thymidine was then carried out. The thickness of the epidermis was also measured. The anthralin therapy leads to significantly greater inhibition of proliferation than the combined therapy with steroid. On the other hand, the combined therapy significantly shortens the duration of the S-phase, which is pathologically lengthened in psoriasis patients. The combined therapy also leads to significantly greater thinning of the epidermis.
D000305:Adrenal Cortex Hormones / Q000008:administration & dosage / Q000627:therapeutic use; D000873:Anthracenes / Q000008:administration & dosage*; D000875:Anthralin / Q000008:administration & dosage* / Q000627:therapeutic use; D002455:Cell Division / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000188:drug therapy*
D000305:Adrenal Cortex Hormones; D000873:Anthracenes; D000875:Anthralin
Untersuchungen zur Wirkungsweise einer Psoriasisbehandlung mit Dithranol im Vergleich zu einer Kombinationsbehandlung mit Dithranol und einem Kortikosteroid.