Microbial conversion of anthracycline antibiotics. II. Characterization of the microbial conversion products of auramycinone by Streptomyces coeruleorubidus ATCC 31276.
Auramycinone was subjected to microbial conversion by Streptomyces coeruleorubidus ATCC 31276, a producer of baumycins. As a result, auramycinone was converted to 11-hydroxyauramycinone and 9-methyl-10-hydroxydaunomycin (feudomycin D). The results implicate auramycinone as a presumptive intermediate in the biosynthesis of 9-methyl-10-hydroxydaunomycin by S. coeruleorubidus.
D018943:Anthracyclines; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D003630:Daunorubicin / Q000031:analogs & derivatives / Q000096:biosynthesis; D009682:Magnetic Resonance Spectroscopy; D009279:Naphthacenes / Q000378:metabolism; D010860:Pigments, Biological; D013053:Spectrophotometry; D013302:Streptomyces / Q000378:metabolism*
D018943:Anthracyclines; D000900:Anti-Bacterial Agents; D009279:Naphthacenes; D010860:Pigments, Biological; C031353:auramycinone; C040036:feudomycin D; D003630:Daunorubicin