Synthesis of thyroglobulin in thyroid carcinoma patients after radioiodine therapy.
Endogenously radioiodinated thyroglobulin (Tg) and the serum concentration of Tg have been measured in patients with metastatic thyroid carcinoma after therapeutic doses of radioiodine. Serial samples of blood were analyzed for both these parameters over a period of 10 to 22 days. The specific activity of Tg (cpm/ng) was calculated for each sample. Among the six patients studied, three showed constant specific activity. The specific activity of the other three fell, indicating the entering of newly synthesized Tg into the circulation. The respective amounts of Tg entering into the circulation in these three patients were 120, 852, and 20,935 ng/ml serum/day.
D002277:Carcinoma / Q000378:metabolism* / Q000532:radiotherapy; D002845:Chromatography; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D009362:Neoplasm Metastasis; D011863:Radioimmunoassay; D013954:Thyroglobulin / Q000096:biosynthesis*; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000532:radiotherapy
D007457:Iodine Radioisotopes; D013954:Thyroglobulin