[Kinetics of the inhibition of succinate dehydrogenase in bull adrenal cortex by malonate and oxaloacetate].
The activity of succinate dehydrogenase from bull adrenal cortex was studied as affected by malonate and oxaloacetate. The both substrate analogs without preincubation (separately and in the mixture) inhibit the enzyme by the competitive type. After a 3 min oxaloacetate preincubation of the enzyme inhibition is of a mixed character. Malonate under these conditions lowers the oxaloacetate effect without changing the type of inhibition. It is supposed that the protective effect is due to a high rate of formation and decay of the enzyme-inhibitory malonate complex.
D000302:Adrenal Cortex / Q000201:enzymology*; D000818:Animals; D002417:Cattle; D007700:Kinetics; D008297:Male; D008314:Malonates / Q000494:pharmacology*; D010071:Oxaloacetates / Q000494:pharmacology*; D011485:Protein Binding; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors*
D008314:Malonates; D010071:Oxaloacetates; C030290:malonic acid; D013385:Succinate Dehydrogenase
Kinetika ingibirovaniia suktsinatdegidrogenazy kory nadpochechnikov byka malonatom i oksaloatsetatom.