title: Cardiovascular examinations and observations of deconditioning during the space shuttle orbital flight test program.
abstract: During the first four flights of the space shuttle, cardiovascular data were obtained on each crewmember as part of the operational medicine requirements for crew health and safety. From monitoring blood pressure and electrocardiographic data, it was possible to estimate the degree of deconditioning imposed by exposure to the microgravity environment. For this purpose, a quantitative cardiovascular index of deconditioning (CID) was derived to aid the clinician in his assessment. Isotonic saline was then investigated as a countermeasure against orthostatic intolerance and found to be effective in partially reversing the hemodynamic consequences. It was observed that the space flight environment of reentry might potentially be arrhythmogenic in at least one individual.
mesh_terms: D000337:Aerospace Medicine; D001145:Arrhythmias, Cardiac / Q000209:etiology; D001794:Blood Pressure; D002320:Cardiovascular Physiological Phenomena; D004562:Electrocardiography; D006339:Heart Rate; D006801:Humans; D007552:Isotonic Solutions; D008297:Male; D011187:Posture; D012965:Sodium Chloride / Q000627:therapeutic use*; D013026:Space Flight; D013997:Time Factors; D014481:United States; D014893:Weightlessness / Q000009:adverse effects*
chemical_list: D007552:Isotonic Solutions; D012965:Sodium Chloride