OM-173, new nanaomycin-type antibiotics produced by a strain of Streptomyces. Taxonomy, production, isolation and biological properties.
Actinomycete strain OM-173, a new soil isolate, was found to produce five nanaomycin-type antibiotics. Antibiotic OM-173 components alpha A, alpha E, alpha B, beta A and beta E were isolated from the fermentation broth of strain OM-173 by solvent extraction, silica gel chromatography and preparative thin-layer chromatography. The components are active against mycoplasmas and to a lesser extent against fungi. Strain OM-173 was identified as a strain of genus Streptomyces and differed apparently from Streptomyces rosa var. notoensis, the nanaomycin-producing strain, in cultural characteristics.
D000935:Antifungal Agents / Q000302:isolation & purification*; D003470:Culture Media; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D008855:Microscopy, Electron, Scanning; D009285:Naphthoquinones / Q000302:isolation & purification / Q000633:toxicity; D013045:Species Specificity; D013302:Streptomyces / Q000145:classification / Q000254:growth & development* / Q000648:ultrastructure
D000935:Antifungal Agents; D003470:Culture Media; D009285:Naphthoquinones; C039864:OM 173