A placebo-controlled, dose-ranging study comparing 0.5 mg, 1 mg and 2 mg flunitrazepam in out-patients.
A placebo-controlled, dose-ranging study was carried out in 18 patients, aged under 65 years, with sleep disturbance to compare the hypnotic effects of 0.5 mg, 1 mg and 2 mg flunitrazepam and placebo. Patients received each treatment in random order for 7 days. Assessments by both doctor and patients were made on entry and at the end of each treatment period. The results showed that the 1 mg flunitrazepam dose was optimal with respect to speed of action, duration of action, quality of sleep and lack of residual clinical sequelae.
D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D005260:Female; D005445:Flunitrazepam / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D007319:Sleep Initiation and Maintenance Disorders / Q000188:drug therapy*; D013997:Time Factors
D005445:Flunitrazepam