Prolonged delirium without anticholinergic signs following amitriptyline overdose.
In a case of acute intoxication with a tricyclic antidepressant (amitriptyline) delirium was prolonged without there being prominent peripheral anticholinergic or electrocardiographic signs. Administration of physostigmine, repeated when necessary, reversed the delirium.
D000639:Amitriptyline / Q000097:blood / Q000506:poisoning*; D003693:Delirium / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D003863:Depression / Q000188:drug therapy; D005260:Female; D006801:Humans; D009661:Nortriptyline / Q000097:blood; D010276:Parasympatholytics; D010830:Physostigmine / Q000627:therapeutic use; D013564:Sympathetic Nervous System / Q000503:physiopathology
D010276:Parasympatholytics; D000639:Amitriptyline; D010830:Physostigmine; D009661:Nortriptyline