Dominant lethal effects of n-butyl glycidyl ether in mice.
Using the dominant lethal assay, the ability of n-butyl glycidyl ether to induce mutations in male mice was investigated. No significant dose-related changes either in pregnancy rates or in average number of implants per pregnant female were found. However, while the results were not altogether conclusive, there was evidence of a significant increase in fetal death rates by the end of the first week after the highest dosage was administered.
D000818:Animals; D010064:Embryo Implantation / Q000187:drug effects; D004852:Epoxy Compounds / Q000633:toxicity*; D004988:Ethers, Cyclic / Q000633:toxicity*; D005260:Female; D005313:Fetal Death; D005799:Genes, Dominant / Q000187:drug effects*; D005804:Genes, Lethal / Q000187:drug effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009153:Mutagens; D009154:Mutation; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects; D013737:Testis / Q000187:drug effects / Q000473:pathology
D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D009153:Mutagens; C022794:n-butyl glycidyl ether