Short-term inhalation test for evaluating industrial hepatotoxicants in rats.
Liver damage was investigated in rat using serum enzyme activities measurements. Responses were recorded 24 h after whole body inhalation exposure to vapors of bromobenzene, carbon tetrachloride, chloroform, o-dichlorobenzene, 1,2-dichloroethane and dimethylformamide as model toxicants. First, rats were exposed during a single 4 h period to different concentrations of each solvent and the minimally active concentration was determined. Second, repeated exposures to chemicals at this concentration level (6 h daily, 2 or 4 days) were used in order to examine whether hepatotoxicity was enhanced. GLDH and SDH are more sensitive and more constant indices than GOT and GPT. It appears that a single exposure period induced more marked serum activities enhancement than repeated exposures.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001273:Atmosphere Exposure Chambers; D056486:Chemical and Drug Induced Liver Injury; D005969:Glutamate Dehydrogenase / Q000097:blood; D007064:L-Iditol 2-Dehydrogenase / Q000097:blood; D008107:Liver Diseases / Q000201:enzymology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012997:Solvents / Q000633:toxicity*
D012997:Solvents; D007064:L-Iditol 2-Dehydrogenase; D005969:Glutamate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase