Effects of acrylamide on locomotion and central monoamine function in the rat.
Male rats receiving acrylamide (ACR) in their drinking water (100 ppm) for a six-week period displayed increased psychomotor stimulation to d-amphetamine (d-A; 1.0 mg/kg SC) under several conditions of handling and drug administration. Following behavioral tests a subset of the animals was sacrificed at 15, 50, 80 and 120 minutes following d-A and the brains removed and dissected for determinations of regional brain levels of several monoamine neurotransmitters and metabolites. ACR rats had elevated levels of 5-hydroxyindoleacetic acid (5-HIAA) in the striatum, septal area, and thalamus. The effect was most pronounced at 15 minutes post-drug with ACR rats not demonstrating a depression in 5-HIAA levels present in controls. Increases in accumben's dopamine and norepinephrine levels, evident after d-A, were of lesser magnitude in ACR-exposed rats. Decreases in dihydroxyphenylacetic acid and homovanillic acid, also evident after d-A, persisted for a longer duration in ACR-exposed rats. Light and electron microscopy of spinal cord, striatum, nucleus accumbens and thalamus did not reveal morphologic abnormalities. Sciatic nerves showed histopathological changes characteristic of multi-focal dying-back peripheral nerve degeneration. It was concluded that acrylamide's effect on the psychomotor stimulant properties of d-A may be related to changes in a serotonergic inhibitory system.
D020106:Acrylamide; D000178:Acrylamides / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001679:Biogenic Amines / Q000502:physiology*; D001826:Body Fluids / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology; D004298:Dopamine / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009474:Neurons / Q000502:physiology; D009638:Norepinephrine / Q000502:physiology; D051381:Rats; D012701:Serotonin / Q000502:physiology
D000178:Acrylamides; D001679:Biogenic Amines; D020106:Acrylamide; D012701:Serotonin; D001058:Apomorphine; D003913:Dextroamphetamine; D004298:Dopamine; D009638:Norepinephrine