[Oxidation and reduction of glutathione in rat organs during the administration of ethonium].
An intramuscular administration of ethonium in a dose of 5 and 10 mg/kg 4-6 h later decreases the level of the reduced glutathione and increases that of oxidized glutathione and the glutathione peroxidase activity in the liver and kidneys of albino rats. The duration of the preparation effect depends on the dose and organ, changes in the glutathione reductase activity in the liver, kidneys, lungs, spleen and heart are not found. Participation of ethonium in formation of peroxides in the organism tissues is shown possible.
D000818:Animals; D005978:Glutathione / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D000644:Quaternary Ammonium Compounds / Q000633:toxicity*; D051381:Rats; D013501:Surface-Active Agents / Q000633:toxicity*; D014018:Tissue Distribution
D000644:Quaternary Ammonium Compounds; D013501:Surface-Active Agents; C004921:Ethonium; D005979:Glutathione Peroxidase; D005978:Glutathione
Okislenie i vosstanovlenie glutationa v organakh krys pri vvedenii étoniia.