Effect of food on bioavailability of rifampicin.
The area under the plasma concentration-time curve of rifampicin was determined with and without food administration in six healthy male volunteers. Rifampicin (10 mg/kg) was administered orally in the fasting state on one occasion and following a wheat-based breakfast on another. Administration of rifampicin with food reduced mean peak plasma concentration and prolonged the time to reach peak concentration (2 versus 4 hours). Total area under the concentration-time curve from 0 to 8 hours and the rate of absorption were also significantly reduced when rifampicin was administered with food.
D000328:Adult; D001682:Biological Availability; D004032:Diet; D005502:Food; D006801:Humans; D007700:Kinetics; D008297:Male; D012293:Rifampin / Q000008:administration & dosage / Q000378:metabolism*; D014908:Triticum
D012293:Rifampin