The preoperative use of cimetidine as a means of preventing symptomatic hypocalcemia following a parathyroid operation.
Cimetidine has been shown to lower circulating PTH levels effectively by causing an intraglandular rearrangement of PTH peptides in human parathyroid tissue in instances of primary hyperparathyroidism. A state of "euparathyroidism" is established. It has been statistically found at a 98.7 per cent confidence level that preoperative treatment with cimetidine effectively prevents symptomatic hypocalcemia postoperatively after parathyroid operations. It is anticipated that cimetidine has provided a tool for the in depth exploration of parathyroid disease.
D000236:Adenoma / Q000601:surgery; D002118:Calcium / Q000097:blood; D002927:Cimetidine / Q000008:administration & dosage*; D006801:Humans; D006996:Hypocalcemia / Q000209:etiology / Q000517:prevention & control*; D010280:Parathyroid Glands / Q000601:surgery*; D010281:Parathyroid Hormone / Q000097:blood; D010282:Parathyroid Neoplasms / Q000601:surgery; D011183:Postoperative Complications / Q000517:prevention & control; D011300:Preoperative Care
D010281:Parathyroid Hormone; D002927:Cimetidine; D002118:Calcium