"Morning-after pill" and antithrombin III.
Plasma antithrombin III (AT III) was studied longitudinally in 15 subjects (13 patients and 2 volunteers), who used the "morning-after pill" (5 mg ethinylestradiol daily for 5 days). The mean decrease in AT III level in the 13 patients was 17% of the pre-treatment value. From additional observations made in 2 of the patients and in the 2 volunteers it is concluded that this decrease is caused by hemodilution due to salt and water retention rather than by a decreased synthesis or increased consumption.
D000293:Adolescent; D000328:Adult; D000990:Antithrombin III / Q000378:metabolism*; D003281:Contraceptives, Postcoital / Q000009:adverse effects / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006801:Humans; D013923:Thromboembolism / Q000139:chemically induced
D003281:Contraceptives, Postcoital; D004997:Ethinyl Estradiol; D000990:Antithrombin III