Studies on [3H]diazepam and [3H]ethyl-beta-carboline carboxylate binding to rat brain in vivo. II. Effects of electroconvulsive shock.
In vivo specific binding of [3H]diazepam was not altered by a single electroconvulsive shock given 5, 30, or 60 min, or 24 h previously, nor 24 h after the last of 10 daily shocks. Similarly, in vivo [3H]ethyl-beta-carboline carboxylate binding was not changed in the brains of animals that had been given a single electroconvulsive shock 30 min previously or a series of 10 daily shocks. Brain areas examined included cerebral cortex, hippocampus, cerebellum, and striatum. However, cortical binding of [3H]diazepam was increased by 32% in animals which were present in the same room while another was being injected and killed. This may represent a response to stress and/or anxiety.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002243:Carbolines / Q000378:metabolism*; D003975:Diazepam / Q000378:metabolism*; D004597:Electroshock; D007211:Indoles / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D002243:Carbolines; D007211:Indoles; C024915:beta-carboline-3-carboxylic acid ethyl ester; D003975:Diazepam