Ultrastructural changes of hepatocyte organelles induced by chemicals and their relation to fat accumulation in the liver.
Fatty liver was induced in the rats shortly after administration of cycloheximide, ethionine, orotic acid, monensin or colchicine. It was strongly suggested that derangements in one or more of the hepatic lipoprotein metabolic steps, which occur at the levels of endoplasmic reticulum, Golgi apparatus and secretory vacuoles lead to an accumulation of triglyceride within hepatocytes.
D000818:Animals; D003078:Colchicine / Q000494:pharmacology; D003513:Cycloheximide / Q000494:pharmacology; D005001:Ethionine / Q000494:pharmacology; D050356:Lipid Metabolism; D008074:Lipoproteins / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008985:Monensin / Q000494:pharmacology; D009963:Orotic Acid / Q000494:pharmacology; D051381:Rats; D014280:Triglycerides / Q000378:metabolism
D008074:Lipoproteins; D014280:Triglycerides; D009963:Orotic Acid; D008985:Monensin; D003513:Cycloheximide; D003078:Colchicine; D005001:Ethionine