title: [Malignant melanoma of the conjunctiva arising from precancerous melanosis, prognosis and treatment].
abstract: A 68-year-old white female with lentigo malignans of the right conjunctiva and lid developed recurrent malignant melanomas of the conjunctiva 16 years after, lesions were treated by local excision and cryotherapy on several occasions. The prognosis of the three different histologic types of malignant melanoma described by Clark: nodular melanoma, superficial spreading melanoma, and lentigo malignans melanoma is discussed. Histologic features associated with the height of the tumor are important factors for prognosis, patients with lentigo malignans melanoma appearing to have a better systemic prognosis than those with superficial spreading or nodular melanoma. Possible therapeutic approaches to this condition are exenteration of the orbit, excision combined with cryotherapy, and excision combined with radiotherapy. The advantages of each of these treatments, and their indications, are discussed.
mesh_terms: D000368:Aged; D003230:Conjunctival Neoplasms / Q000473:pathology* / Q000628:therapy; D005260:Female; D006801:Humans; D008545:Melanoma / Q000473:pathology* / Q000628:therapy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000628:therapy; D011230:Precancerous Conditions / Q000473:pathology* / Q000628:therapy; D011379:Prognosis
vernacular_title: Mélanome malin de la conjonctive développé à partir d'une mélanose précancéreuse, pronostic et traitement.