Failure of vasoactive intestinal peptide to stimulate aldosterone production.
The effect of vasoactive intestinal peptide (VIP) was studied on the aldosterone production of isolated rat adrenal glomerulosa cells. The peptide up to a concentration of 3 X 10(-7) mol/l failed to influence aldosterone production by isolated glomerulosa cells as well as to modify the response to a submaximal (2.5 X 10(-9) mol/l) concentration of angiotensin II. Therefore VIP, previously found in the adrenal zona glomerulosa by immunohistochemistry, is unlikely to exert a direct effect on the glomerulosa cells.
D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism; D000450:Aldosterone / Q000096:biosynthesis*; D000804:Angiotensin II / Q000494:pharmacology / Q000502:physiology; D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014660:Vasoactive Intestinal Peptide / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology*; D014664:Vasodilation / Q000187:drug effects
D000804:Angiotensin II; D014660:Vasoactive Intestinal Peptide; D000450:Aldosterone