[Phenytoin kinetics in toxic serum levels].
After discontinuing Phenytoin, the elimination kinetics was determined in 12 patients with toxic serum levels of more than 30 micrograms/ml. The half-lives of the elimination were between 72 and 122 h (97 h). The Michaelis constant amounted to 16,3 +/- 5,6 micrograms/ml and per day and the maximum rate of metabolism 9,9 +/- 1,1 microgram/ml and per day. The elimination half-lives was dependent on the concentration: the higher the serum concentration the longer the half-live. A method applicable in general practice for determining the course of the serum level with initial values of more than 30 micrograms/ml was described.
D000293:Adolescent; D000328:Adult; D002648:Child; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D010672:Phenytoin / Q000097:blood* / Q000506:poisoning
D010672:Phenytoin
Phenytoinkinetik bei toxischem Serumspiegel.