title: Treatment of massive intraoperative brain swelling.
abstract: Massive intraoperative brain swelling is an infrequent but catastrophic occurrence. In this report, we describe the use of very large doses of thiopental as a means of treating such swelling. In our initial 11 cases (5 arteriovenous malformations, 4 hematomas, and 2 penetrating injuries), this approach produced the following outcomes: 6 patients made a good recovery, 2 are moderately disabled, 1 is severely disabled, and 2 are dead. These results indicate that this condition, which once was considered unmanageable, can indeed be managed and that treatment often results in an acceptable outcome. More recent experience in an additional 6 patients suggests that the use of planned deep thiopental anesthesia, with induced cerebral silence, during intracranial surgery may even prevent the occurrence of this phenomenon.
mesh_terms: D001927:Brain Diseases / Q000601:surgery*; D001929:Brain Edema / Q000188:drug therapy*; D001930:Brain Injuries / Q000601:surgery; D004305:Dose-Response Relationship, Drug; D006407:Hematoma, Epidural, Cranial / Q000601:surgery; D006408:Hematoma, Subdural / Q000601:surgery; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000601:surgery; D007431:Intraoperative Complications / Q000188:drug therapy; D011379:Prognosis; D013874:Thiopental / Q000627:therapeutic use*
chemical_list: D013874:Thiopental