Polymorphism of Qa and Tla loci of the mouse.
Congenic lines carrying H-2 haplotypes derived from wild mice were typed serologically with polyclonal and monoclonal antibodies specific for Tla, Qa-1, and Qa-2 antigens. The typing revealed the presence of a minimum of five Tla, four Qa-1, and three Qa-2 alleles in the 32 lines. Two new Tla, two new Qa-1, and one new Qa-2 alleles could be described. This polymorphism of Tla and Qa loci is lower than that detected at the K and D loci in the same lines. The serological typing for Qa-2 antigens correlates remarkably well with previously published results of typing with cytolytic T lymphocytes. This correlation supports the identify of loci detected by the two methods.
D000818:Animals; D005260:Female; D005787:Gene Frequency; D005796:Genes; D006649:Histocompatibility Antigens / Q000235:genetics*; D006650:Histocompatibility Testing; D008297:Male; D051379:Mice; D008805:Mice, Inbred A / Q000235:genetics; D008810:Mice, Inbred C57BL / Q000235:genetics; D010641:Phenotype; D011110:Polymorphism, Genetic
D006649:Histocompatibility Antigens