Inhibition by GABA, baclofen and gabapentin of dopamine release from rabbit caudate nucleus: are there common or different sites of action?
Slices of rabbit caudate nucleus were preincubated with [3H]dopamine then superfused and stimulated electrically. Baclofen, GABA and gabapentin 10(-4) and 10(-3) mol/l reduced the stimulation-evoked overflow of tritium in a similar manner. The effects of the substances were reinvestigated while one of them was present in a high concentration throughout the superfusion. These interaction experiments showed that baclofen and GABA have a common presynaptic site of action which is different from that of gabapentin.
D000085:Acetates / Q000494:pharmacology*; D000588:Amines; D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D001640:Bicuculline / Q000494:pharmacology; D001665:Binding Sites; D002421:Caudate Nucleus / Q000187:drug effects* / Q000378:metabolism; D003509:Cyclohexanecarboxylic Acids; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D000077206:Gabapentin; D066298:In Vitro Techniques; D008297:Male; D009557:Nipecotic Acids / Q000494:pharmacology; D011817:Rabbits; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D000085:Acetates; D000588:Amines; D003509:Cyclohexanecarboxylic Acids; D009557:Nipecotic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin; D001418:Baclofen; D004298:Dopamine; D001640:Bicuculline