Hypergravity promotes cell proliferation.
When HeLa cells, chicken embryo fibroblasts, sarcoma Galliera cells, Friend leukemia virus transformed cells and human lymphocytes are cultured in a hypergravitational field (e.g. 10 X g) proliferation rate is increased by 20-30%, whereas glucose consumption per cell is lower than at 1 X g. Tracking of cell movements on gold-coated substrates reveals that cell migration is hindered at high-g. These findings suggest that under gravitational stress the cell is either capable of shifting to other metabolic pathways and/or consumes less energy at high-g than at 1 X g. This work describes ground-based investigations related to experiments to be performed on future Spacelab missions.
D000818:Animals; D002455:Cell Division; D002460:Cell Line; D002465:Cell Movement; D002498:Centrifugation; D002642:Chick Embryo; D005347:Fibroblasts / Q000166:cytology; D005622:Friend murine leukemia virus; D005947:Glucose / Q000378:metabolism; D006112:Gravitation; D006367:HeLa Cells / Q000166:cytology; D006801:Humans; D006874:Hydrostatic Pressure; D007942:Leukemia, Experimental / Q000473:pathology; D008214:Lymphocytes / Q000166:cytology; D051381:Rats; D012509:Sarcoma / Q000473:pathology; D013026:Space Flight
D005947:Glucose