Effects of neuroleptics on the lipid peroxidation and peroxide metabolism enzyme activities in various discrete areas of the rat brain.
The effects of a 7-day treatment with Haloperidol or reserpine (in both cases 0.1 mg/kg per day) were studied on the superoxide dismutase and catalase activities and the lipid peroxidation in various discrete regions of the rat brain. It was found that these neuroleptics change the lipid peroxidation and the activities of the enzymes in similar directions in the brain areas tested.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D002374:Catalase / Q000378:metabolism*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000378:metabolism*; D013997:Time Factors
D008054:Lipid Peroxides; D012110:Reserpine; D002374:Catalase; D013482:Superoxide Dismutase; D006220:Haloperidol