Somatosensory thresholds in monkeys exposed to acrylamide.
Six monkeys were trained to report detection of a vibratory or electrical stimulus applied to the fingertip. The vibratory stimuli were presented at two frequencies (40 and 150 Hz). Thresholds were determined with a tracking procedure before, during, and after dosing. Each monkey served as its own control. Four monkeys were dosed orally with 10 mg/kg of acrylamide 5 days a week until the appearance of toxic signs. The total administered dose varied between 320 and 450 mg/kg. The other two monkeys served as time-matched controls. All the monkeys were observed 5 days a week. They were also weighed and presented with a visuomotor task (pickup test) twice a week. Weight loss usually preceded the onset of gross behavioral disturbances, such as loss of balance, tremor, or decreased activity. Impaired coordination, as revealed with the pickup test, paralleled weight loss. Electrical sensitivity was not affected. Vibration sensitivity, however, fell during dosing and remained impaired for several months after dosing ceased, outlasting all the other effects. Recovery of the other indices occurred relatively soon after dosing ended. These data indicate that vibration sensitivity testing can trace the time course of intoxication and recovery in toxic peripheral neuropathies. Furthermore, the differential results obtained with vibratory and electrical stimulation are consonant with a primary effect on end-organ receptors.
D000178:Acrylamides / Q000633:toxicity*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004558:Electric Stimulation; D005260:Female; D008254:Macaca nemestrina; D009043:Motor Activity / Q000187:drug effects*; D013497:Sural Nerve / Q000187:drug effects; D014202:Tremor / Q000139:chemically induced
D000178:Acrylamides