Presence of cytidine 5'-tetraphosphate in commerical samples of cytidine 5'-triphosphate.
A contaminant compound has been isolated from commercial samples of CTP by ion-exchange chromatography on a Dowex-1 column. It has been characterized as cytidine 5'-tetraphosphate from its ultraviolet spectrum, labile and total phosphate content, and periodate consumption. It is present in proportions from 0.3 to 3.9%, apparently regardless of the method of preparation, age of sample, or commericial source of CTP.
D002852:Chromatography, Ion Exchange; D003570:Cytidine Triphosphate / Q000032:analysis*; D003597:Cytosine Nucleotides / Q000032:analysis* / Q000302:isolation & purification*; D004340:Drug Contamination / Q000032:analysis*
D003597:Cytosine Nucleotides; C039829:cytidine 5'-tetraphosphate; D003570:Cytidine Triphosphate