[Anti-arrhythmic action of preparations of the dihydropyridine series].
The derivatives of the dihydropyridine series, sodium salt of 2,6-dimethyl-3,5-diethoxycarbonyl-1,4-dihydronicotinic acid (drug I) and disodium salt of 2,6-dimethyl-1,4-dihydropyridine-3,6-bis-carbonyloxyacetic acid (drug II), reduce or completely prevent (depending on the dose) arrhythmias of different types (disturbances of atrioventricular conduction, extrasystoles, heart fibrillation) induced by vasopressin, calcium chloride and strophantine. Study of the lipid composition and activity of lipid-dependent enzymes of sarcoplasmic reticulum membranes has demonstrated that the antiarrhythmic effect of the drugs under study is linked with their antioxidant action favouring the preservation of enzymes involved in Ca2+ transport.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism; D002122:Calcium Chloride / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D006329:Heart Conduction System / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D050356:Lipid Metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism; D011725:Pyridines / Q000627:therapeutic use*; D011817:Rabbits; D051381:Rats; D013328:Strophanthins / Q000494:pharmacology; D014667:Vasopressins / Q000494:pharmacology
D000889:Anti-Arrhythmia Agents; D011725:Pyridines; D013328:Strophanthins; D014667:Vasopressins; D002122:Calcium Chloride
Antiaritmicheskoe deĭstvie nekotorykh preparatov digidropiridinovogo riada.