In vivo evaluation of ocular inserts of hydrogel impregnated with antibiotics for trachoma therapy.
Sustained release of antibiotics from hydrogel matrices in the eye was studied for the purpose of developing a new method for trachoma therapy. Copolymers of N-vinylpyrrolidone were moulded into an ocular insert and impregnated with erythromycin or erythromycin estolate. The antibiotic-hydrogel inserts completely suppressed the chlamydia trachomatis infection in the owl monkey eyes. The drug elution rates were a little lower in vivo than in vitro. By comparison of the drug elution rate in the human eye with that in the owl monkey eye, similar therapeutic effect is expected in the treatment of human trachoma.
D000818:Animals; D001029:Aotus trivirgatus; D003692:Delayed-Action Preparations; D004917:Erythromycin / Q000008:administration & dosage*; D004918:Erythromycin Estolate / Q000008:administration & dosage; D005069:Evaluation Studies as Topic; D006801:Humans; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D014141:Trachoma / Q000188:drug therapy*
D003692:Delayed-Action Preparations; D020136:Hydrogel, Polyethylene Glycol Dimethacrylate; D011092:Polyethylene Glycols; D004917:Erythromycin; D004918:Erythromycin Estolate