Synthesis and biological activity of heterocyclic acyl-cholines.
Five new heterocyclic acyl-cholines were synthetized through 1,3-dipolar cycloaddition and their adrenergic, cholinergic and histaminergic activity evaluated. The tested compounds did not show any significant activity; some of them, in particular the isoxazole derivative (X), shift the dose-response curve of norepinephrine to the left.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001337:Autonomic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D002794:Choline / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D004347:Drug Interactions; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007583:Jejunum / Q000187:drug effects; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D051381:Rats; D014649:Vas Deferens / Q000187:drug effects
D001337:Autonomic Agents; D001285:Atropine; D002794:Choline