title: [Pathogenesis of acrokeratosis Bazex].
abstract: A 67-year-old male patient with typical signs of acrokeratosis Bazex is presented. The psoriasiform skin lesions appeared 9 months after diagnosis of an oesophagus neoplasm. Clinically there was a marked hepatopathy but no signs of metastases. Histological, immunofluorescence-histological, and ultrastructural findings revealed a capillaritis with humoral as well as cellular inflammation. With treatment of the neoplasm the paraneoplasia regressed under additional treatment with topical steroids. The vitamin A deficit could not be normalized by oral or parenteral vitamin A substitution. We discuss some mechanisms in formal pathogenesis.
mesh_terms: D000368:Aged; D004938:Esophageal Neoplasms / Q000150:complications / Q000628:therapy; D006801:Humans; D007642:Keratosis / Q000209:etiology* / Q000473:pathology; D008107:Liver Diseases / Q000150:complications; D008297:Male; D010257:Paraneoplastic Syndromes / Q000209:etiology* / Q000473:pathology; D014801:Vitamin A / Q000627:therapeutic use; D014802:Vitamin A Deficiency / Q000150:complications / Q000188:drug therapy
chemical_list: D014801:Vitamin A
vernacular_title: Pathogenetischer Beitrag zur Akrokeratose Bazex.