title: The treatment of quinine poisoning with charcoal haemoperfusion.
abstract: Quinine poisoning is rare but serious. Attempts at treatment by active removal have proved unsuccessful because of its high degree of protein binding. We describe two cases of non-accidental overdose of quinine (19.5 g and 15 g) with potentially fatal serum quinine levels. Both patients were treated by 2 periods of charcoal haemoperfusion during which quinine clearances of up to 125 ml/min were obtained. Both patients recovered, though one had some residual visual disturbance. We suggest that in cases of quinine poisoning, charcoal haemoperfusion may be a safe and effective method of drug removal, to be used with stellate ganglion block.
mesh_terms: D000328:Adult; D002606:Charcoal; D006464:Hemoperfusion; D006801:Humans; D008297:Male; D011041:Poisoning / Q000628:therapy; D011803:Quinine / Q000097:blood / Q000506:poisoning*
chemical_list: D002606:Charcoal; D011803:Quinine