title: GABA and glycine effects on the bipolar cells of the carp retina.
abstract: Effects of GABA and glycine applied electrophoretically were examined on bipolar cells in the carp retina. When applied at the outer plexiform layer, GABA produced a small depolarization in on-center cells, but a small hyperpolarization in off-center cells. These effects were concluded to be mediated by photoreceptor cells. When applied at the inner plexiform layer, GABA produced a hyperpolarization in on-center cells but no response in off-center cells. This response was resistant to Co2+ ions. Thus GABA is very like the inhibitory neurotransmitter from amacrine to on-center bipolar cells. Glycine, when applied in either layer, did not have a noticeable effect on either type of bipolar cells.
mesh_terms: D000818:Animals; D002347:Carps; D003035:Cobalt / Q000494:pharmacology; D003623:Dark Adaptation; D005998:Glycine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009411:Nerve Endings / Q000187:drug effects; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D010775:Photic Stimulation; D012160:Retina / Q000166:cytology* / Q000187:drug effects; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
chemical_list: D003035:Cobalt; D005680:gamma-Aminobutyric Acid; C018021:cobaltous chloride; D005998:Glycine