Cariostatic effect of palatinose on experimental dental caries in rats.
Specific pathogen-free Sprague-Dawley rats infected with Streptococcus mutans MT8148R (serotype c) developed a severe dental caries when fed a diet containing 56% sucrose (diet #2000). Complete replacement of the dietary sucrose with palatinose, a structural isomer of sucrose, however, resulted in negligible caries induction and plaque accumulation. Replacement of half of the sucrose content of diet #2000 with palatinose induced dental caries; however, the caries score was significantly lower than that induced by diet #2000. No significant reduction in caries development was observed when a quarter of the dietary sucrose was replaced with palatinose.
D000818:Animals; D002327:Cariostatic Agents / Q000494:pharmacology*; D003731:Dental Caries / Q000382:microbiology; D004037:Diet, Cariogenic; D004187:Disaccharides / Q000494:pharmacology*; D007534:Isomaltose / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013295:Streptococcus mutans / Q000378:metabolism; D013395:Sucrose / Q000494:pharmacology
D002327:Cariostatic Agents; D004187:Disaccharides; D013395:Sucrose; D007534:Isomaltose; C008189:isomaltulose