Absence of serum-stimulated lipase activity and altered lipid content in milk from a patient with type I hyperlipoproteinaemia.
We measured the serum-stimulated lipase activity, fatty acid content, and various biochemical parameters in the breast milk of a lactating mother suffering from familial lipoprotein lipase deficiency and of healthy control subjects. Serum-stimulated lipase activity was virtually undetectable in milk from our patient and the total fatty acid content was low. The fatty acid composition differed from normal showing a marked absolute and relative increase in the content of lauric (C12:0) and myristic (C14:0) fatty acids and considerably reduced levels of oleic (C18:1) and especially linoleic (C18:2) acids. Other fatty acid species showed lesser changes in concentration. Besides a reduced calcium concentration in the milk from our patient, other biochemical parameters were not significantly different from control subjects.
D000328:Adult; D002118:Calcium / Q000032:analysis; D005227:Fatty Acids / Q000032:analysis; D005228:Fatty Acids, Essential / Q000032:analysis; D005230:Fatty Acids, Nonesterified / Q000032:analysis; D005260:Female; D006801:Humans; D008072:Hyperlipoproteinemia Type I / Q000201:enzymology*; D006951:Hyperlipoproteinemias / Q000201:enzymology*; D007774:Lactation; D008055:Lipids / Q000032:analysis*; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008895:Milk, Human / Q000032:analysis / Q000201:enzymology*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000201:enzymology*
D005227:Fatty Acids; D005228:Fatty Acids, Essential; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D008071:Lipoprotein Lipase; D002118:Calcium