Asbestos fibers, plasma and inflammation.
Fibrin clots have been detected at sites of inflammation, and kinins have been implicated as mediators of the vascular phenomena of acute inflammation, systemic shock, and disseminated intravascular coagulation. It is now reported that both negatively and positively charged asbestos fibers shorten the partial thromboplastin time of human plasma, indicating coagulation of the plasma. A sample containing short (less than 5 micron in length) chrysotile fibers is ineffective. Only the negatively charged amphiboles (crocidolite and amosite) are able to activate factor XII (Hageman factor). This particular effect of the amphiboles is enhanced by high molecular weight kininogen and leads to kinin formation.
D001194:Asbestos / Q000633:toxicity*; D001777:Blood Coagulation / Q000187:drug effects*; D005174:Factor XII / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D007249:Inflammation / Q000097:blood*; D007705:Kinins / Q000096:biosynthesis; D010314:Partial Thromboplastin Time; D010949:Plasma / Q000187:drug effects; D013997:Time Factors
D007705:Kinins; D001194:Asbestos; D005174:Factor XII