title: Ethanol-induced hyperglycemia mediated by the central nervous system.
abstract: A marked difference in ethanol-induced hyperglycemia was found in two lines of mice (LS/Ibg and SS/Ibg) with differential central nervous system sensitivity to ethanol. The LS/Ibg line had a greater sensitivity to the ethanol-induced hyperglycemia, but this difference was not found after administration of hypnotic doses of pentobarbital or halothane. The two lines did not differ in their response to glucose tolerance tests. Fasting, adrenalectomy, and pretreatment with alpha- and beta-adrenergic antagonists (dibenamine and propranolol) eliminated the ethanol-induced hyperglycemic response. Results from intracerebroventricular injections of ethanol indicated that the ethanol-induced hyperglycemia was mediated by the central nervous system.
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002490:Central Nervous System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity*; D005215:Fasting; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects; D012894:Sleep Stages / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D011941:Receptors, Adrenergic; D000431:Ethanol