title: Lymphocytic choriomeningitis virus. VI. Isolation of a glycoprotein mediating neutralization.
abstract: A structural glycoprotein of lymphocytic choriomeningitis virus was obtained in pure form by immunoaffinity chromatography using a monoclonal antibody with high neutralizing activity. It blocked neutralization of viral infectivity by antibody and in polyacrylamide gel electrophoresis it migrated with an apparent molecular weight of 44 X 10(3). We conclude that the isolated material is identical with the previously described gp44 (GP-1).
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis; D002846:Chromatography, Affinity; D004591:Electrophoresis, Polyacrylamide Gel; D006023:Glycoproteins / Q000276:immunology / Q000302:isolation & purification*; D007739:L Cells / Q000382:microbiology; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology / Q000302:isolation & purification*; D051379:Mice; D008970:Molecular Weight; D009500:Neutralization Tests; D011817:Rabbits; D014764:Viral Proteins / Q000276:immunology / Q000302:isolation & purification*
chemical_list: D000911:Antibodies, Monoclonal; D006023:Glycoproteins; D014764:Viral Proteins