Monoclonal antibodies to anchoring fibrils for the diagnosis of epidermolysis bullosa.
Murine monoclonal antibodies to human anchoring fibrils reacted with human and monkey cervix, tongue, esophagus, and vagina. Rat, mouse, and guinea pig tissues were negative. In 11 patients with dystrophic recessive epidermolysis bullosa there was no reaction by immunofluorescence and immunoelectron microscopy. Other forms of epidermolysis bullosa had normal reactivity.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D004820:Epidermolysis Bullosa / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D005260:Female; D006801:Humans; D051379:Mice; D008854:Microscopy, Electron; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000276:immunology*
D000911:Antibodies, Monoclonal