Liver collagen in Opisthorchis viverrini infected hamsters following praziquantel treatment.
The dose of praziquantel required to achieve a 100% worm reduction in O. viverrini infected hamsters was found to be 300 mg/kg body weight. The drug was administered orally for 1 day by dividing a total dose into 3 equal doses at 4 h interval. The effect of praziquantel treatment on liver collagen was followed by measuring liver collagen content in at various intervals after administration of the drug. A decrease in collagen content in the infected livers occurred within a few weeks following the treatment suggesting a recovery from liver fibrosis.
D000818:Animals; D003094:Collagen / Q000378:metabolism*; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D007546:Isoquinolines / Q000008:administration & dosage*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D009889:Opisthorchiasis / Q000378:metabolism*; D011223:Praziquantel / Q000008:administration & dosage* / Q000494:pharmacology
D007546:Isoquinolines; D011223:Praziquantel; D003094:Collagen