[Effect of brietal and gamma-OH on the bioelectric activity of the cerebral cortex and deep temporal structures in SEEG studies in patients with epilepsy].
Eleven SEEG investigations were analysed in patients with temporal epilepsy after separate intravenous injection of Brietal and gamma-OH. The authors discuss a modification of the background activity and pathological seizure discharges in the cortex and deep structures of the temporal lobes. Attention is called to an evident increase of the quantitative and qualitative elements of excitation or manifestation of seizure activity not present previously. The activating effect of the these preparations on the pathological bioelectric activity without presence of clinically observable seizures suggests the possibility of existence of inhibitory mechanisms at the levels below the cortex and limbic system, probably in the reticular system of the brain stem. It was found that in the used doses the administration of both preparations was completely safe. Brietal and gamma-OH are good preparations facilitating more accurate diagnosis of epilepsy.
D000200:Action Potentials / Q000187:drug effects; D000293:Adolescent; D000328:Adult; D002540:Cerebral Cortex / Q000503:physiopathology*; D004569:Electroencephalography / Q000379:methods; D004833:Epilepsy, Temporal Lobe / Q000503:physiopathology*; D005260:Female; D006801:Humans; D006885:Hydroxybutyrates; D008032:Limbic System / Q000503:physiopathology*; D008297:Male; D008723:Methohexital; D012978:Sodium Oxybate; D013268:Stimulation, Chemical
D006885:Hydroxybutyrates; D012978:Sodium Oxybate; D008723:Methohexital
Wpływ brietalu i gamma-OH na czynność bioelektryczna kory i głebokich struktur skroniowych mózgu w badaniach SEEG u chorych z padaczka.