[Effects of various antibiotics and natural mycotoxins on the hematopoietic stem cells of the bone marrow in normal and adjuvant-treated rats].
This experiment was carried out, in order to investigate the effect of antibiotics and natural mycotoxin on the hematopoietic stem cells at the normal and inflammatory condition. Adjuvant-treated rats (Aj-rats) are considered as a model of human rheumatoid arthritis. We measured the CFU-C and CFU-E of bone marrow of normal and Aj-rats which were injected with large (1.0 g/kg X 3) and small doses (0.5 g/kg X 3) of ampicillin (ABPC), cefazolin (CEZ), chloramphenicol (CP) and fusarenon-X (F-X). In Aj-rats the number of CFU-C was 1.5 times higher and CFU-E 60% less than normal. Injection of large doses of ABPC enhanced markedly the numbers of CFU-C in Aj-rats and suppressed slightly CFU-E in normal rats. Large doses of CEZ inclined to increase CFU-C and decreased CFU-E in normal and Aj-rats. Injection of small doses of CP tended to increase CFU-C and to decrease CFU-E, and large doses of CP to suppress both CFU-C and CFU-E levels in normal or Aj-rats. F-X, natural mycotoxin suppressed markedly both CFU-C and CFU-E levels of normal rats, and slightly the CFU-E in Aj-rats. These results suggest that one should pay attention to the fact that some doses of antibiotics or natural mycotoxin might be harmful on the bone marrow hematopoietic stem cells.
D000667:Ampicillin / Q000494:pharmacology*; D000818:Animals; D001169:Arthritis, Experimental / Q000188:drug therapy; D001853:Bone Marrow / Q000187:drug effects*; D002437:Cefazolin / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology*; D005260:Female; D006400:Hematocrit; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D007958:Leukocyte Count; D051381:Rats; D011919:Rats, Inbred Strains; D012717:Sesquiterpenes / Q000494:pharmacology*; D014255:Trichothecenes / Q000494:pharmacology*
D012717:Sesquiterpenes; D014255:Trichothecenes; C002469:fusarenon-X; D002701:Chloramphenicol; D000667:Ampicillin; D002437:Cefazolin