[Action of tomizine (4-methoxy-6-aminopyrimido (4,5-b) (1,4)thiazine hydrochloride) on the physicochemical properties of the enzymes of folic acid metabolism--dihydrofolate reductase and nonspecific dihydrofolate reductase].
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004347:Drug Interactions; D005492:Folic Acid / Q000378:metabolism*; D005493:Folic Acid Antagonists / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology; D051381:Rats; D013499:Surface Properties; D013843:Thiazines / Q000494:pharmacology*
D000970:Antineoplastic Agents; D005493:Folic Acid Antagonists; D013843:Thiazines; C012066:tomizine; D005492:Folic Acid
Deĭstvie tomizina (khlorgidrat 4-metoksi-6-amino-pirimido (4,5-b) (1,4) tiazina) na nekotorye fiziko-khimicheskie svoĭstva fermentov folievogo obmena--digidrofolatreduktazu i nespetsificheskuiu digidrofolatreduktazu.