Urokinase-treatment of fresh laser irradiation-induced vitreous hemorrhage.
Using a ruby laser, we induced vitreous hemorrhage in each eye of 12 rabbits. On the following day either 25,000 Ploug units of urokinase or saline were injected into the eyes of each rabbit. Urokinase did not accelerate the absorption of blood from the vitreous but prevented the development of severe vitreous fibrosis which replaced the hemorrhage in seven of the control eyes.
D000818:Animals; D002386:Cataract / Q000139:chemically induced; D005128:Eye Diseases / Q000188:drug therapy; D005260:Female; D006470:Hemorrhage / Q000188:drug therapy*; D007834:Lasers / Q000009:adverse effects*; D008297:Male; D011817:Rabbits; D012598:Sclerosis; D014568:Urokinase-Type Plasminogen Activator / Q000009:adverse effects / Q000627:therapeutic use*; D014605:Uveitis / Q000139:chemically induced; D014822:Vitreous Body / Q000187:drug effects / Q000293:injuries* / Q000473:pathology
D014568:Urokinase-Type Plasminogen Activator