The genetic basis of non-disjunction: increased incidence of hyperploidy in oocytes from F1 hybrid mice.
Oocytes from parental mice strains NMRI/Han, C57/bl and Balb/c and from F1 hybrid lines were analysed for aneuploidy due to non-disjunction after gonadotropin-stimulated ovulation. No hyperploid oocytes were present in five of the strains studied. F1 hybrids from crosses of NMRI/HanxC57/bl did ovulate, however, a significantly increased number of hyperploid oocytes, although females from their parental strains show a rather low incidence of non-disjunction. The evidence for a genetic basis for non-disjunction is assessed and possible causative factors are discussed.
D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D008297:Male; D008540:Meiosis; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009630:Nondisjunction, Genetic; D009865:Oocytes / Q000166:cytology*; D010060:Ovulation; D011003:Ploidies