Effects of pantethine and its metabolites on fatty acid oxidation in rat liver mitochondria.
The mechanism of the activating effect of pantethine [D-bis-(N-pantothenyl-beta-aminoethyl)disulfide] on fatty acid oxidation was investigated in rat liver mitochondria. Pantethine, pantetheine and 4'-phosphopantetheine activated three steps of fatty acid oxidation, i.e., acyl-CoA synthetase, carnitine, acyltransferase and intramitochondrial oxidation, to various extents. Although their effects may have been partly due to CoASH derived from them, they also had specific effects.
D000214:Acyl Coenzyme A / Q000378:metabolism; D000818:Animals; D002333:Carnitine Acyltransferases / Q000378:metabolism; D003066:Coenzyme A Ligases / Q000378:metabolism; D005227:Fatty Acids / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction; D010204:Pantetheine / Q000031:analogs & derivatives / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D000098859:Long-Chain-Fatty-Acid-CoA Ligase
D000214:Acyl Coenzyme A; D005227:Fatty Acids; D012097:Repressor Proteins; D029701:Saccharomyces cerevisiae Proteins; D013438:Sulfhydryl Compounds; D010204:Pantetheine; C005425:pantethine; D002333:Carnitine Acyltransferases; D003066:Coenzyme A Ligases; C090799:FAA2 protein, S cerevisiae; D000098859:Long-Chain-Fatty-Acid-CoA Ligase; C003129:4'-phosphopantetheine