[Simulation of the pharmacokinetics of aminoglycosides in the kidneys: single and continuous intake of sisomicin and gentamicin by rats].
The pharmacokinetics of sisomicin and gentamicin in the cortical and medullary layers of the kidneys was studied on rats. The antibiotics were administered daily in doses of 12.5 and 25 mg/kg a day. The levels of the antibiotics in the cortical layer were much higher than those in the medullary layer. The use of a twice as higher dose in the first case resulted in a less than a two-fold increase in the drug concentration, while in the second case the increase was more than two-fold. Prognosis of the pharmacokinetics of aminoglycosides used for 8-16 days was achieved with the help of the constants of the two-compartmental model. It was shown that the actual levels of sisomicin and gentamicin in the kidney medullary layer did not significantly differ from the estimated ones and the levels of the drugs in the cortical layer were much lower than the predicted ones. The distorted linearity of the aminoglycoside pharmacokinetics must be mainly due to saturation of the cortical layer with the drugs.
D000818:Animals; D005839:Gentamicins / Q000008:administration & dosage / Q000378:metabolism*; D007672:Kidney Cortex / Q000378:metabolism*; D007679:Kidney Medulla / Q000378:metabolism*; D007700:Kinetics; D051381:Rats; D011919:Rats, Inbred Strains; D012853:Sisomicin / Q000008:administration & dosage / Q000378:metabolism*
D005839:Gentamicins; D012853:Sisomicin
Modelirovanie farmakokinetiki aminoglikozidov v pochkakh: odnokratnoe i dlitel'noe vvedenie sizomitsina i gentamitsina krysam.