[Molecular mechanisms of radiation death of lymphoid cells. Protein poly-ADP-ribosylation in thymocyte fractions].
A study was made of the process of poly-ADP-ribosylation of proteins in cells of radioresistant and radiosensitive fractions of mouse thymus lymphocytes after irradiation of isolated cells with a dose of 25 Gy. It was shown that activation of ADP-ribosylation of proteins occurred simultaneously with the formation of single-strand DNA breaks in thymocytes, and the degree of activation in radioresistant and radiosensitive fractions was nearly the same.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects; D002478:Cells, Cultured; D002843:Chromatin / Q000378:metabolism* / Q000528:radiation effects; D004260:DNA Repair; D004278:DNA, Superhelical / Q000378:metabolism* / Q000528:radiation effects; D008297:Male; D051379:Mice; D009702:Nucleoside Diphosphate Sugars / Q000378:metabolism*; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism* / Q000528:radiation effects; D011836:Radiation Tolerance; D013950:Thymus Gland / Q000166:cytology / Q000378:metabolism* / Q000528:radiation effects
D002843:Chromatin; D004278:DNA, Superhelical; D009702:Nucleoside Diphosphate Sugars; D011064:Poly Adenosine Diphosphate Ribose
Issledovanie molekuliarnykh mekhanizmov radiatsionnoĭ gibeli limfoidnykh kletok. Poli-ADF-ribozilirovanie belkov vo fraktsiiakh timotsitov.