title: Interaction between the macrophage system and IgA immune complexes in IgA nephropathy.
abstract: In nine patients with IgA nephropathy, the function of the mononuclear phagocyte system was assessed by measuring in vivo clearance of anti-D coated red blood cells (RBC) and in vitro phagocytosis of sensitised RBC by monocytes. A strict correlation was found between in vivo macrophage function and in vitro monocyte phagocytosis. Statistical correlations were also found between in vivo clearance values and IgAIC and C3d values. A defective macrophage and monocyte function affects patients with major signs of clinical activity, highest IgAIC values, signs of complement activation and the most unfavourable clinical course.
mesh_terms: D000936:Antigen-Antibody Complex; D003167:Complement Activation; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A; D066298:In Vitro Techniques; D007674:Kidney Diseases / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D010587:Phagocytosis
chemical_list: D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A