[The system of active transport of organic acids in the proximal tubules of rats with hereditary retinal degeneration (Campbell strain)].
Active transport of organic acids (ATOA) in proximal renal tubules of Campbell, Wistar and random-bred rats was studied by contact microfluorometry with anion fluorescein as a marker. Beginning with the 60th day of life this transport in Campbell rats was characterized by a lower equilibrium uptake of fluorescein by the tubules, by altered sensitivity to AMP and adenosine, and by no response to unilateral nephrectomy. It is assumed that ATOA in Campbell rats plays a certain role in the pathogenesis of retinitis pigmentosa.
D000241:Adenosine / Q000502:physiology; D000249:Adenosine Monophosphate / Q000502:physiology; D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D001693:Biological Transport, Active; D004195:Disease Models, Animal; D005452:Fluoresceins / Q000378:metabolism; D006626:Hippurates / Q000378:metabolism*; D007687:Kidney Tubules, Proximal / Q000378:metabolism*; D008297:Male; D009392:Nephrectomy; D051381:Rats; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D012174:Retinitis Pigmentosa / Q000378:metabolism*; D014527:Uric Acid / Q000097:blood / Q000378:metabolism*
D001647:Bile Acids and Salts; D005452:Fluoresceins; D006626:Hippurates; D014527:Uric Acid; D000249:Adenosine Monophosphate; D000241:Adenosine
Sostoianie sistemy aktivnogo transporta organicheskikh kislot v proksimal'nykh kanal'tsakh krys s nasledstvennoĭ degeneratsieĭ setchatki (liniia Kempbell).