Intra-arterial adriamycin chemotherapy for bladder cancer. Semiselective intra-arterial chemotherapy with compression of the femoral arteries at the time of injection.
Twenty patients with bladder cancer were treated by semiselective intra-arterial chemotherapy with Adriamycin. Ten of them were given the agent while the femoral arteries were compressed, to prevent loss of the agent into the external iliac arteries. The other ten were given Adriamycin without this compression. Clinical and pathological responses of tumor and the side-effects were examined in these two groups. The results of the comparative study led us to the conclusion that the compression technique is a simple and valuable means of decreasing the side-effects of Adriamycin and increasing tumor response.
D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology; D003250:Constriction; D004317:Doxorubicin / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005263:Femoral Artery; D006801:Humans; D007269:Injections, Intra-Arterial / Q000379:methods; D008297:Male; D008875:Middle Aged; D011859:Radiography; D001749:Urinary Bladder Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000473:pathology
D004317:Doxorubicin