In vitro response of Blastocystis hominis to antiprotozoal drugs.
Ten antiprotozoal drugs were tested in vitro against four axenic strains of the intestinal parasite Blastocystis hominis. Inhibitory drugs in order of effectiveness were emetine, metronidazole, furazolidone, trimethoprim sulfamethoxazole, 5-chloro-8-hydroxy-7-iodo-quinoline (Entero-Vioform), and pentamidine. Moderately inhibitory were two quinolines other than iodochlorhydroxquin. These were chloroquine and 5,7-diiodo-8-hydroxy-quinoline (Floraquin). Diloxanide furoate was not inhibitory. Paromomycin and other antibiotics were not inhibitory. Entero-Vioform and metronidazole have been effective in human and higher primate diarrhea caused by B. hominis.
D000818:Animals; D000981:Antiprotozoal Agents / Q000494:pharmacology*; D004640:Emetine / Q000494:pharmacology; D056890:Eukaryota / Q000187:drug effects*; D005663:Furans / Q000494:pharmacology; D005664:Furazolidone / Q000494:pharmacology; D008795:Metronidazole / Q000494:pharmacology; D010303:Paromomycin / Q000494:pharmacology; D010419:Pentamidine / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D013420:Sulfamethoxazole / Q000494:pharmacology; D014295:Trimethoprim / Q000494:pharmacology
D000981:Antiprotozoal Agents; D005663:Furans; D011804:Quinolines; D008795:Metronidazole; D005664:Furazolidone; D010303:Paromomycin; D010419:Pentamidine; D014295:Trimethoprim; D013420:Sulfamethoxazole; D004640:Emetine; C004932:diloxanide furoate