[Buerger's disease: current diagnostic and therapeutic concepts].
This paper reviews our actual knowledge on Buerger's disease, a segmental inflammatory processors of peripheral, medium sized arteries and veins, and includes 33 patients of our clinic. In more than 50 p. 100 of cases antielastin antibodies were increased and the complement factor C4 decreased. 23 p. 100 had circulating immune complexes. Clinical experience and these immunological findings suggest medical treatment by antiinflammatory drugs like aspirin at relatively high doses or indomethazine. In resistant cases prednisone and azathioprine can suppress the activity of disease. If a limb is threatened by amputation the eventual implantation of a femoro-crural or cruro-crural bypass should be discussed.
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D011379:Prognosis; D013919:Thromboangiitis Obliterans / Q000175:diagnosis* / Q000503:physiopathology / Q000628:therapy; D013997:Time Factors
Maladie de Buerger: concepts diagnostiques et thérapeutiques actuels.