[Mechanism of the effect of methylcobalamin on the recovery of neuromuscular functions in mechanical and toxin denervation].
It has been shown in experiments on rats that daily administration of methylcobalamine in a dose of 50 micrograms/100 g bw produces marked activation of the regeneration of mechanically damaged axons of motoneurons. Systematic administration of the drug has a protective action on the development of neuromuscular transmission blockade induced by botulinum toxoid.
D000818:Animals; D001369:Axons / Q000187:drug effects; D001905:Botulinum Toxins / Q000633:toxicity*; D003714:Denervation / Q000379:methods; D009046:Motor Neurons / Q000187:drug effects; D009416:Nerve Regeneration / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D051381:Rats; D013997:Time Factors; D014805:Vitamin B 12 / Q000031:analogs & derivatives* / Q000494:pharmacology
C019476:mecobalamin; D001905:Botulinum Toxins; D014805:Vitamin B 12
K mekhanizmu vliianiia metilkobalamina na protsessy vosstanovleniia funktsiĭ nervno-myshechnykh priborov pri mekhanicheskoĭ i toksinnoĭ denervatsii.