Impact of microcirculation and physiologic considerations on clinical hyperthermia.
Changes in tumor tissue oxygenation and acidity were determined using ultramicroelectrodes, and presented in histogram fashion. The effect of Hyperthermia and HpD phototherapy were tested. It was found that both modalities affect tumor microcirculation, causing a marked drop in oxygen availability. Tissue pH is decreased by Hyperthermia, but not by phototherapy. These effects are long lasting at least for 24 hours after treatment.
D000818:Animals; D006415:Hematoporphyrins / Q000627:therapeutic use; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced; D008325:Mammary Neoplasms, Experimental / Q000098:blood supply / Q000378:metabolism / Q000628:therapy*; D051379:Mice; D008833:Microcirculation; D009368:Neoplasm Transplantation; D010101:Oxygen Consumption; D010789:Phototherapy
D006415:Hematoporphyrins