Antibiotics and corneal epithelial wound healing.
The healing of a de-epithelialized cornea was measured by serial standardized photography after treatment with different antibiotics. Histological studies were also performed. Low doses of bacitracin (500 units/mL), gentamicin sulfate (3 mg/mL), neomycin (3.5 mg/mL), and chloramphenicol (4 mg/mL) did not retard normal epithelial healing. However, higher doses of bacitracin (10,000 units/mL), gentamicin sulfate (10 mg/mL), and neomycin (8 mg/mL) significantly inhibited reepithelialization.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D003315:Cornea / Q000187:drug effects* / Q000473:pathology; D065306:Corneal Injuries; D003320:Corneal Ulcer / Q000188:drug therapy*; D004848:Epithelium; D005260:Female; D008297:Male; D009883:Ophthalmic Solutions; D012038:Regeneration; D014945:Wound Healing / Q000187:drug effects*
D000900:Anti-Bacterial Agents; D009883:Ophthalmic Solutions