Effect of continuous local microdose norethisterone enanthate on the epididymis of adult rat.
Unilateral implantation of a small silastic capsule containing crystalline Norethisterone Enanthate (NE, average observed rate of release, 17-22 micrograms/24 h) into the epididymal fat-pad of adult rats induced drastic impairment of epididymal functional anatomy in the adjacent epididymis six weeks later without affecting the contralateral epididymis. Tubular elements in the ipsilateral epididymis were highly shrunken with their luminal epithelial height greatly reduced and the lumen devoid of spermatozoa as compared with the normal epididymis (full of spermatozoa) on the sham operated contralateral side.
D000818:Animals; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology*; D004822:Epididymis / Q000187:drug effects*; D008297:Male; D009640:Norethindrone / Q000031:analogs & derivatives* / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013094:Spermatozoa / Q000187:drug effects
D003276:Contraceptives, Oral; D003280:Contraceptives, Oral, Synthetic; C024319:norethindrone enanthate; D009640:Norethindrone