Bacterial invasion of the sinus mucosa.
Pathohistological examinations show that bacterial infection of the sinus mucosa starts in the mucosal secretion, spreads out to the glandular cells, which are the points of least resistance, and only reaches the deeper mucosal layer when the normal arrangement of the epithelial cells and the basal membrane are broken up. Hence treatment of sinus infection starts with the restauration of the mucosa defence system and when using antibiotics it is essential that antibacterial active concentrations are established both in sinus mucosa and sinus secretion.
D006098:Granulocytes / Q000276:immunology; D006801:Humans; D008443:Maxillary Sinus / Q000382:microbiology; D009092:Mucous Membrane / Q000382:microbiology; D012852:Sinusitis / Q000276:immunology / Q000382:microbiology*