[Effect of levamisole on hemolysin production in the spleen of rats after chronic administration of thyrotropin].
Experiments on 40 male Wistar rats were made to study the effect of levamisole on the production of hemolysins in experimental hyperthyrosis. Levamisole (2.5 mg/kg bw) was administered once 1 day before immunization with sheep red blood cells. Levamisole was discovered to appreciably activate hemolysin production in the spleen of rats with experimental hyperthyrosis, which manifested a demonstrable inhibition of immune response. A possible mechanism of levamisole action is suggested.
D000818:Animals; D006460:Hemolysin Proteins / Q000096:biosynthesis*; D006728:Hormones / Q000008:administration & dosage; D007978:Levamisole / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000378:metabolism*; D013972:Thyrotropin / Q000008:administration & dosage*
D006460:Hemolysin Proteins; D006728:Hormones; D007978:Levamisole; D013972:Thyrotropin
Vliianie levamizola na produktsiiu gemolizinov v selezenke krys pri khronicheskom vvedenii tireotropina.