Induction of sister-chromatid exchange in human lymphocytes by vitamin B6.
Vitamin B6, or pyridoxine hydrochloride, enhanced sister-chromatid exchange (SCE) rates in cultured normal human lymphocytes. No increase was found in SCE frequency when lymphocytes were treated with pyridoxal-5-phosphate (P-5-P) or 4-pyridoxic acid (4-PA) to which vitamin B6 is finally converted.
D002478:Cells, Cultured; D003434:Crossing Over, Genetic / Q000187:drug effects*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D011732:Pyridoxal Phosphate / Q000633:toxicity; D011735:Pyridoxic Acid / Q000633:toxicity; D011736:Pyridoxine / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D011735:Pyridoxic Acid; D011732:Pyridoxal Phosphate; D011736:Pyridoxine