Mutagenic activity of N-nitrosomethamphetamine and N-nitrosoephedrine.
The mutagenicity of N-nitrosomethamphetamine (NMA) and N-nitrosoephedrine (NEP), which were synthesized in our laboratory, was examined by the modified pre-incubation method of Ames assay using Salmonella typhimurium TA100 and TA98. Both nitroso compounds showed significant mutagenic activity in the presence of hamster S9.
D000818:Animals; D006224:Cricetinae; D008694:Methamphetamine / Q000031:analogs & derivatives* / Q000633:toxicity; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009152:Mutagenicity Tests; D009602:Nitrosamines / Q000633:toxicity*; D051381:Rats; D012475:Salmonella / Q000187:drug effects
D009602:Nitrosamines; C017918:N-nitrosoephedrine; D008694:Methamphetamine; C039826:N-nitrosomethamphetamine