Segregation of chromosomes into the spermatozoa of a man heterozygous for a 14;21 Robertsonian translocation.
Twenty-four spermatozoa from a man heterozygous for a Robertsonian translocation (45,XY,-14,-21,+t(14q;21q) were studied cytogenetically in order to determine the meiotic segregation of the translocation. When compared to the expected 1:1 ratio we observed a greater number of chromosomally normal sperm than sperm with the balanced translocation. Three sperm carried the translocation in an unbalanced form.
D002901:Chromosomes, Human, 13-15; D002904:Chromosomes, Human, 21-22 and Y; D006579:Heterozygote; D006801:Humans; D008297:Male; D008540:Meiosis; D013094:Spermatozoa / Q000648:ultrastructure*; D014178:Translocation, Genetic