title: Effects of pulsing electromagnetic fields on bone growth and articular cartilage.
abstract: Observations made during treatment of juvenile pseudarthrosis by pulsing electromagnetic fields (PEMF) suggested that bone growth might be altered. PEMF applied to immature rabbits under conditions of continuous stimulation (24 hours/day for 8 weeks) produced no major changes in bone growth. Continuous stimulation by PEMF induced a statistically significant increase (22%) in femoral articular cartilage glycosaminoglycan. Intermittent PEMF stimulation (12 hours with stimulation/12 hours without stimulation) for 18 weeks produced no significant change in bone growth or time of epiphyseal plate closure. No significant changes in the physical characteristics of growing bone were observed with any treatment.
mesh_terms: D000818:Animals; D001846:Bone Development; D002358:Cartilage, Articular / Q000254:growth & development*; D055590:Electromagnetic Phenomena / Q000627:therapeutic use*; D005260:Female; D006025:Glycosaminoglycans / Q000378:metabolism; D006132:Growth Plate / Q000502:physiology; D055909:Magnetic Field Therapy; D011817:Rabbits
chemical_list: D006025:Glycosaminoglycans