title: Early effects of high-dosed absorbable amoscanate on rat brain.
abstract: An oily suspension of the absorbable form of amoscanate was administered to young adult albino rats in single or repeated oral doses of 25, 125 and 500 mg/kg. At least 3 consecutive doses of 125 or 500 mg/kg were needed to induce a brain lesion. The early change consisted of necrosis of the ependyma of the lateral ventricles, indicating that intoxication may have occurred via the cerebrospinal fluid.
mesh_terms: D000814:Aniline Compounds / Q000633:toxicity*; D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced* / Q000648:ultrastructure; D004159:Diphenylamine / Q000031:analogs & derivatives / Q000633:toxicity*; D004805:Ependyma / Q000187:drug effects* / Q000648:ultrastructure; D005260:Female; D017879:Isothiocyanates; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013861:Thiocyanates / Q000633:toxicity*
chemical_list: D000814:Aniline Compounds; D017879:Isothiocyanates; D013861:Thiocyanates; D004159:Diphenylamine; C012391:amoscanate