Effect of prolonged inhibition of histidine decarboxylase on tissue histamine concentrations.
In rats, chronic infusion of alpha-fluoromethyl histidine, a selective irreversible inhibitor of mammalian histidine decarboxylase, caused a marked depletion of histamine in all tissues examined. There were no gross pharmacological effects associated with this depletion.
D000818:Animals; D001921:Brain / Q000378:metabolism; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D005753:Gastric Mucosa / Q000378:metabolism; D006632:Histamine / Q000378:metabolism*; D006639:Histidine / Q000031:analogs & derivatives*; D006640:Histidine Decarboxylase / Q000037:antagonists & inhibitors*; D007031:Hypothalamus / Q000378:metabolism; D008297:Male; D008762:Methylhistidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D008762:Methylhistidines; D006639:Histidine; C028309:alpha-fluoromethylhistidine; D006632:Histamine; D002262:Carboxy-Lyases; D006640:Histidine Decarboxylase