Effect of estrogen pretreatment on the intestinal cytochrome P-450 in female rats.
The effect of estrogen hormones on the cytochrome P-450-linked hydroxylation system of rat small intestine was investigated. Estrogens were found to increase the activity of the intestinal arylhydrocarbon hydroxylase as well as the level of cytochrome P-450 in female rats. There was essentially no difference in the increase of the concentration of cytochrome P-450 due to the duration of pretreatment.
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology*; D004970:Estrone / Q000494:pharmacology*; D007421:Intestine, Small / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D004970:Estrone; D004958:Estradiol; D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases; D010634:Phenobarbital