title: [Biologic availability of caffeine in subjects with regard to the variability of the elimination half life].
abstract: 400 mg of caffeine and sodium salicylate (= 220 mg of caffeine) were given orally and intravenously (at an interval of one week) to six test persons. The serum levels were determined; and certain pharmacokinetic parameters were measured, using an open one-compartment model. Finally, the absolute bioavailability was calculated. With one of the test persons this experiment was repeated ten times to evaluate the extent of the intra-individual variability of the half-life period and its repercussions on bioavailability.
mesh_terms: D000328:Adult; D001682:Biological Availability; D001835:Body Weight; D002110:Caffeine / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate
chemical_list: D002110:Caffeine
vernacular_title: Zur Bioverfügbarkeit von Coffein bei Probanden unter Berücksichtigung der Variabilität der Eliminationshalbwertszeiten.