title: Neuroeffector mechanisms of the defense reaction in the rat.
abstract: Electrical stimulation of the dorsal periaqueductal gray matter (DPAG) eliciting flight behavior in awake rats caused an increase in arterial blood pressure (BP), heart rate (HR) and respiration in rats anesthetized with urethane. The hypertension was markedly reduced by 5 mg/kg of intravenously injected hexamethonium or bretylium, virtually abolished by 5 mg/kg of phentolamine and partially antagonized by 0.1 mg/kg of the alpha 1-adrenoceptor blocker, prazosin. The tachycardia induced by DPAG stimulation was partially antagonized by hexamethonium or bretylium and abolished by propranolol (5 mg/kg, IV) or practolol (5 mg/kg, IV), but not affected by N-butylscopolamine (10 mg/kg, IV). Phentolamine increased basal HR and abolished the tachycardic response caused by either brain stimulation or intravenous noradrenaline. Prazosin moderately decreased the response to noradrenaline, but did not affect basal HR or the tachycardia induced by brain stimulation. The increase in respiratory amplitude occurring during brain stimulation was abolished by phentolamine as well as by prazosin, while the increase in respiratory rate was moderately reduced by phentolamine and propranolol. These results demonstrate that the cardiovascular component of the defense reaction of the rat is almost entirely due to a sharp increase in sympathetic tone. They also suggest that the hyperventilation induced by aversive brain stimulation is modulated by central and peripheral adrenergic mechanisms.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001950:Bretylium Tosylate / Q000494:pharmacology; D002086:Butylscopolammonium Bromide / Q000494:pharmacology; D004558:Electric Stimulation; D004924:Escape Reaction / Q000187:drug effects / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006584:Hexamethonium Compounds / Q000494:pharmacology; D008297:Male; D009451:Neuroeffector Junction / Q000187:drug effects / Q000502:physiology*; D010487:Periaqueductal Gray / Q000502:physiology*; D010646:Phentolamine / Q000494:pharmacology; D011217:Practolol / Q000494:pharmacology; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects
chemical_list: D006584:Hexamethonium Compounds; D002086:Butylscopolammonium Bromide; D001950:Bretylium Tosylate; D011433:Propranolol; D011217:Practolol; D011224:Prazosin; D010646:Phentolamine