title: Changes in tissue oxygenation and acidity induced by localized microwave hyperthermia and hematoporphyrin phototherapy, an update.
abstract: Changes in tumor tissue oxygenation and acidity were determined using ultramicroelectrodes, and presented in histogram fashion. The effect of Hyperthermia and Hpd photo-therapy were tested. It was found that both modalities affect tumor microcirculation, causing a marked drop in oxygen availability. Tissue pH is decreased by Hyperthermia, but not by phototherapy. These effects are long lasting, at least for 24 hours after treatment.
mesh_terms: D000136:Acid-Base Equilibrium / Q000187:drug effects / Q000528:radiation effects; D000818:Animals; D005260:Female; D006415:Hematoporphyrins / Q000627:therapeutic use*; D006863:Hydrogen-Ion Concentration; D006979:Hyperthermia, Induced; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism / Q000628:therapy; D051379:Mice; D008809:Mice, Inbred C3H; D008839:Microelectrodes; D008872:Microwaves; D010101:Oxygen Consumption / Q000187:drug effects / Q000528:radiation effects; D010778:Photochemotherapy; D013696:Temperature
chemical_list: D006415:Hematoporphyrins