Plant antitumor agents, 19. Novel triterpenes from Maprounea africana.
Four new pentacyclic triterpenes have been isolated from Maprounea africana. These triterpenes are members of the previously unknown urs-12-en-29-oic acid series. The structures of these compounds were deduced from spectral and chemical evidence. The parent compound, maprounic acid, was identified as 3B-hydroxyurs-12-en-29-oic acid. The remaining three triterpenes were identified as maprounic acid 3-p-hydroxybenzoate, 7 beta-hydroxymaprounic acid 3-p-hydroxybenzoate, and 2 alpha-hydroxymaprounic acid 2,3-bis-p-hydroxybenzoate. Of the four triterpenes, only the 7 beta-hydroxy derivative exhibited in vivo P-388 activity.
D000107:Acetylation; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000032:analysis*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D010946:Plants, Medicinal / Q000032:analysis*; D013329:Structure-Activity Relationship; D014315:Triterpenes / Q000032:analysis* / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D014315:Triterpenes