Ocular involvement in disseminated intravascular coagulation (DIC).
A 27-year-old white woman with anorexia, abdominal pain, arthralgias, spiking fever, diarrhea, and bizarre neurologic symptoms developed yellowish-gray plaques surrounded by hemorrhage in the posterior choroid of both eyes. Progressive thrombocytopenia, hypofibrinoginemia, and accelerated fibrinolysis supported the diagnosis of disseminated intravascular coagulation (DIC). Death occurred from complications of DIC. Widespread thrombotic occlusion of small blood vessels was present in numerous organs, including the posterior choriocapillaris and larger choroidal vessels of both eyes. Other ocular vessels were normal.
D000328:Adult; D002829:Choroid / Q000098:blood supply / Q000473:pathology; D004211:Disseminated Intravascular Coagulation / Q000150:complications* / Q000175:diagnosis / Q000473:pathology; D005260:Female; D006801:Humans; D010857:Pigment Epithelium of Eye / Q000473:pathology; D012164:Retinal Diseases / Q000150:complications* / Q000473:pathology; D013927:Thrombosis / Q000150:complications; D014603:Uveal Diseases / Q000150:complications