A 60,000 molecular weight human pituitary glycopeptide stimulates adrenal androgen secretion.
An approximately 60,000 mol wt glycopeptide has been isolated from acetone-dried human pituitary glands which stimulates production of the adrenal androgen dehydroepiandrosterone, but not cortisol, in acute suspensions of collagenase-dispersed dog adrenal cells. Adrenal androgen secretion has generally been considered, like cortisol, to be under the control of ACTH. This new pituitary glycopeptide, with a molecular weight greater than that of proopiocortin, ACTH, PRL, or LH, may help explain instances during adrenarche, puberty, aging, and stress in which cortisol and adrenal androgen metabolism diverge.
D000311:Adrenal Glands / Q000187:drug effects / Q000378:metabolism*; D000738:Androsterone / Q000378:metabolism*; D000818:Animals; D001681:Biological Assay; D004285:Dogs; D006020:Glycopeptides / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D008297:Male; D008970:Molecular Weight; D010902:Pituitary Gland / Q000032:analysis*; D010908:Pituitary Hormones, Anterior / Q000494:pharmacology
D006020:Glycopeptides; D010908:Pituitary Hormones, Anterior; D000738:Androsterone; D006854:Hydrocortisone