title: [N-acetyl-cystein-(NAC)-activated creatinkinase (CK) and isoenzyme CK-MB in the serum of children].
abstract: We have examined the variation of creatinekinase levels (NAC-activated) with age in 170 children. The subjects included 40 neonates, 18 premature neonates, 40 small babies, 32 infants and 40 schoolchildren. The enzyme activity of CK-MM was very high in the first hours after delivery and remained high for a few days. The isoenzyme MB in healthy newborns also showed a higher catalytic concentration. These values (about 2-12 U/l) reached normal levels of adults within 4 months of life (0.5-5 U/l). The same rule applied to CK-MM: enzyme activities of 160 U/l and more in the first days of life declined to 16-75 U/l during the first 4 months. No correlation between birth trauma and the increase in serum-CK was found. Because of the increased CK-MM (and CK-MB) found in normal newborns screening for Duchenne-type muscular dystrophy should be postponed for a few weeks after delivery. In view of the relatively high endogenous serum CK-MB in the neonates (release of CK-MB from the skeletal muscle) the test lacks the specificity for cardiac damage. Intramuscular injections of several drugs lead to a distinct increase in CK activity. A rise of CK-MM was seen 4-24 h after catheterization of the heart.
mesh_terms: D000111:Acetylcysteine; D000293:Adolescent; D006328:Cardiac Catheterization; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007234:Infant, Premature; D007273:Injections, Intramuscular; D007527:Isoenzymes; D009205:Myocarditis / Q000201:enzymology; D011041:Poisoning / Q000201:enzymology; D012016:Reference Values; D014777:Virus Diseases / Q000201:enzymology
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase; D000111:Acetylcysteine
vernacular_title: N-Acetyl-Cystein-(NAC)-aktivierte Kreatinkinase (CK) und Isoenzym CK-MB im Serum von Kindern.