Effect of ethionine on hematologic and serum biochemical values in fasted calves.
DL-Ethionine (0.87 g/kg of body weight) was administered IV to 6 fasted (12 hour) Holstein bull calves (4.5 months old). Fasting, which was continued for an additional 48 hours, caused a body weight loss (10.82% to 11.96%), a mild increase in PCV, and an increase in the serum free fatty acids (1.204 mmole/L, fasted; 0.949 mmole/L, fasted ethionine-treated calves). Ethionine caused a decrease in the total plasma proteins from 6.5 g/dl to 5.5 g/dl and total serum lipids from 493.9 mg/dl to 307.8 mg/dl. The decrease in the serum esterified fats included all the lipid fractions (triglycerides, cholesterol, and phospholipids). The calves' WBC and serum enzymes aspartate aminotransferase and L-alanine aminotransferase remained within normal range.
D000818:Animals; D002417:Cattle / Q000097:blood*; D002418:Cattle Diseases / Q000097:blood* / Q000378:metabolism; D005001:Ethionine / Q000494:pharmacology*; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood / Q000378:metabolism; D005234:Fatty Liver / Q000097:blood / Q000378:metabolism / Q000662:veterinary*; D005260:Female; D006400:Hematocrit / Q000662:veterinary; D007774:Lactation / Q000187:drug effects; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D011247:Pregnancy
D005230:Fatty Acids, Nonesterified; D008055:Lipids; D005001:Ethionine