Endemic HBV infection, tissue autoantibodies and HLA. Analysis of a Sardinian population.
Serum samples of 405 HLA-typed individuals from four Sardinian villages were analyzed for HB virus markers and for tissue autoantibodies. Of the 59% individuals who had been exposed to HBV, 10% were healthy carriers; they showed a weak association with the HLA-B40 specificity compared with the immune or non-exposed groups, and a negative association of DR4, limited to females. Tissue autoantibodies were significantly associated with DR1 and more weakly with B14, probably through linkage disequilibrium.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006509:Hepatitis B / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D012737:Sex Factors
D001323:Autoantibodies; D006680:HLA Antigens; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens