Effect of polyphloretin phosphate on the contraceptive action of a polyethylene intrauterine device in rats.
A polyethylene intrauterine device (IUD) inserted in one horn of the rat uterus on Day 2 of pregnancy prevented implantation in 9 out of 12 rats in the horn with the device. When polyphloretin phosphate (PPP), a substance known to inhibit alkaline phosphatase, was administered to such rats from Day 1 till Day 5 of pregnancy, the device prevented implantation in only 3 out of 12 rats in the horn with the device. PPP also significantly reduced the raised levels of endometrial alkaline phosphatase observed in the presence of the device. A significant rise in endometrial alkaline phosphatase was seen in such animals not administered PPP. It is suggested that there is a correlation between the anti-implantation effect of an IUD and raised levels of endometrial alkaline phosphatase in rats.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D010064:Embryo Implantation; D004717:Endometrium / Q000201:enzymology; D005260:Female; D007434:Intrauterine Devices; D010693:Phloretin / Q000031:analogs & derivatives*; D011095:Polyethylenes; D011121:Polyphloretin Phosphate / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats
D011095:Polyethylenes; D011121:Polyphloretin Phosphate; D000469:Alkaline Phosphatase; D010693:Phloretin