The effect of concussion on cerebral uptake of 2-deoxy-D-glucose in rat.
The effect of concussion on 2-deoxy-D-glucose uptake by various regions of rat brain was investigated. The relative uptake of 2-deoxy-D-glucose was measured at 10 and 20 min post-concussion. The uptake did not change significantly from control rats at 20 min post-concussion. This may be reflective of transient nature of concussion. The uptake was higher in cortex and lower in subcortical structures at 10 min post-concussion. These changes are similar to those reported in spreading cortical depression. Spreading cortical depression may thus be a component of concussion mechanism.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D001924:Brain Concussion / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D013181:Cortical Spreading Depression; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution