Urinary excretion of methylparaben and its metabolites in preterm infants.
A high-performance liquid chromatographic (HPLC) assay to quantitate methylparaben in urine was developed. Standard curves were linear and recovery of the paraben from urine averaged 82.6%. The urinary excretion of methylparaben in six preterm infants (less than or equal to 31 weeks gestational age), who were receiving intramuscular injections of a paraben-containing gentamicin formulation, ranged from 13.2 to 88.1%. Small quantities of the metabolite, p-hydroxybenzoic acid, were detected by GC-MS.
D001711:Biotransformation; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D005839:Gentamicins / Q000008:administration & dosage; D005998:Glycine / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D008297:Male; D010226:Parabens / Q000652:urine*
D005839:Gentamicins; D010226:Parabens; C015358:methylparaben; D005998:Glycine