title: Response to ionising radiation in Duchenne muscular dystrophy.
abstract: Using lymphoblastoid cell cultures the response to gamma (gamma)-radiation, was examined in 6 Duchenne muscular dystrophy (DMD) patients; 2 clinically normal males as negative controls, and 2 patients with ataxia telangiectasia (AT) showing sensitivity to ionising radiation as positive controls. In a series of experiments, cell recovery and growth at day 2 post radiation, was determined after 5 separate gamma-irradiation dose levels: 50, 100, 150, 200 and 300 rads. The DMD cell strains showed a radiation dose response that was significantly greater than in cells from 2 normal males, while both DMD and normal cells were significantly less responsive than were AT-sensitive cell strains.
mesh_terms: D000293:Adolescent; D000328:Adult; D002460:Cell Line; D002648:Child; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D009136:Muscular Dystrophies / Q000532:radiotherapy*; D011879:Radiotherapy Dosage