Acetohydroxamate in struvite stones: in vivo study.
This report describes the results obtained with a combination of acetohydroxamic acid (AHA) and antibacterial agents in 13 patients with recurrent struvite stones complicated by refractory infections with urease-producing bacteria. Intravenous antibiotic pulses plus oral AHA achieved urine sterilisation in all. Then oral chemotherapy plus AHA was given for a mean period of 10.8 +/- 5.4 months. In four patients, the urine remained sterile, but in all the patients urinary pH remained below 6.4 and urinary NH4+ below 40 mg/dl. Despite the persistence of urea-splitting bacteria, the radiographic data showed an arrest of stone growth during the first year of treatment.
D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D006801:Humans; D006877:Hydroxamic Acids / Q000008:administration & dosage*; D008274:Magnesium / Q000378:metabolism; D017616:Magnesium Compounds; D010710:Phosphates / Q000378:metabolism; D000069877:Struvite; D014510:Urease / Q000037:antagonists & inhibitors; D014545:Urinary Calculi / Q000150:complications / Q000188:drug therapy*; D014552:Urinary Tract Infections / Q000150:complications / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D006877:Hydroxamic Acids; D017616:Magnesium Compounds; D010710:Phosphates; C006358:acetohydroxamic acid; D000069877:Struvite; D014510:Urease; D008274:Magnesium