Changes induced by Gramoxon in tissue phospholipids and phospholipid fatty acids in mouse and guinea-pig.
Following administration of the LD50 or the LD100 of Gramoxon (PQ), the phospholipids (PL) of the lung, liver and kidney were separated and both the PLs and the fatty acids isolable from them were examined quantitatively. The different doses of PQ caused different changes of the saturated and unsaturated fatty acids in the various organs. The changes in the PL unsaturated fatty acids point to PQ-induced lipid peroxidation enhancement and membrane damage.
D000818:Animals; D005227:Fatty Acids / Q000032:analysis*; D005231:Fatty Acids, Unsaturated / Q000032:analysis; D006168:Guinea Pigs; D007668:Kidney / Q000187:drug effects; D008054:Lipid Peroxides / Q000032:analysis; D008099:Liver / Q000187:drug effects; D008168:Lung / Q000187:drug effects; D008297:Male; D051379:Mice; D010269:Paraquat / Q000633:toxicity*; D010743:Phospholipids / Q000032:analysis*
D005227:Fatty Acids; D005231:Fatty Acids, Unsaturated; D008054:Lipid Peroxides; D010743:Phospholipids; D010269:Paraquat