Morphine potentiates seizures induced by GABA antagonists and attenuates seizures induced by electroshock in the rat.
In a naloxone-reversible, dose-dependent manner, morphine (10-50 mg/kg i.p.) protected against seizures induced by maximal electroshock and increased the incidence and severity of seizures induced by bicuculline, in rats. Morphine also potentiated seizures induced by isoniazid and by picrotoxin. Thus, opiate activity influences the expression of seizures in contrasting ways depending upon the mode of seizure induction. Since morphine consistently potentiated seizures induced by interference with GABA transmission, it appears that GABAergic systems may be of particular significance for the elucidation of the varied effects of morphine on seizure susceptibility.
D000818:Animals; D001640:Bicuculline / Q000494:pharmacology; D004357:Drug Synergism; D004597:Electroshock; D018756:GABA Antagonists; D007538:Isoniazid / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology* / Q000517:prevention & control
D001640:Bicuculline; D018756:GABA Antagonists; D007538:Isoniazid; D009020:Morphine; D009270:Naloxone; D010852:Picrotoxin