title: [Changes in physical capacity and lung function after a single parenteral alcohol dose].
abstract: The purpose of this study was to test whether a parenteral infusion of ethanol had any influence on pulmonary function or cardio-pulmonary capacity. 11 healthy male test persons supplied with an infusion of 0.4 g ethanol per kg body weight in isotonic saline (25--38 g ethanol) and of 400 mls of isotonic solution alternatively. The following measurements were taken: Body-plethysmography, Ergospirometry using a bicycle ergometer, ECG, measuring cardiac frequency, blood gases and lactate concentration. At average maximal alcohol blood levels of 0.61% we found a significant decrease of the residual volume without changes of the bronchial resistance. At increasing physical loads on the bicycle ergometer we found a significant decrease of the maximal oxygen uptake at the same watt ratings and the same maximal respiratory minute volume. The results indicate a shift of respiratory balance and a decrease of the cardiac output after supply of alcohol.
mesh_terms: D000079:Acetaldehyde / Q000097:blood; D000293:Adolescent; D000328:Adult; D000403:Airway Resistance / Q000187:drug effects; D000431:Ethanol / Q000008:administration & dosage* / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects*; D012129:Respiratory Function Tests; D014797:Vital Capacity / Q000187:drug effects
chemical_list: D000431:Ethanol; D000079:Acetaldehyde
vernacular_title: Veränderungen der körperlichen Leistungsfähigkeit und der Lungenfunktion bei einmaliger parenteraler Alkoholbelastung.