Experimental allergic neuritis-like disease in rabbits after injection with influenza vaccines mixed with gangliosides and adjuvants.
An experimental allergic neuritis-like disease was induced in rabbits 3 to 8 weeks after injection with large doses of influenza vaccines mixed with gangliosides, cholesterol, and Freund complete adjuvant. The inclusion of gangliosides was essential to induce the experimental allergic neuritis-like disease. In trials with six different lots of vaccine, both swine influenza and non-swine influenza vaccines produced by four different manufacturers induced experimental allergic neuritis-like disease in 26 of 43 inoculated rabbits.
D000818:Animals; D005620:Freund's Adjuvant; D005732:Gangliosides; D009980:Influenza A virus; D007252:Influenza Vaccines; D009444:Neuritis, Autoimmune, Experimental / Q000139:chemically induced / Q000276:immunology / Q000473:pathology*; D009975:Orthomyxoviridae; D011817:Rabbits
D005732:Gangliosides; D007252:Influenza Vaccines; D005620:Freund's Adjuvant