title: Preweaning nutrition and fat development in baboons.
abstract: Using the baboon as a model, we tested the hypothesis that preweaning food intake influences the number of adipocytes at weaning. Two groups of 12 newborn baboons each were fed either a concentrated or a diluted Similac formula from birth to 18 weeks of age. Baboons fed the concentrated Similac were 38% heavier (P less than 0.01) and had 87% more fat mass (P less than 0.01) than the baboons fed diluted Similac. The mean adipocyte volume and adipocyte number were measured directly in 10 individual fat depots, and the total number of adipocytes were estimated for each baboon. The difference in fat mass was due to differences (P less than 0.01) in mean adipocyte volume, which was 0.22 nl in overfed baboons and 0.09 nl in underfed baboons. There was no significant diet effect on the estimated total number of fat cells; nor on 8 of 10 depots in which adipocyte number was directly measured. These results indicate that, in baboons, preweaning caloric intake has little or no influence on the number of fat cells at the age of weaning.
mesh_terms: D000273:Adipose Tissue / Q000033:anatomy & histology* / Q000166:cytology; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001823:Body Composition; D002452:Cell Count; D004032:Diet; D002149:Energy Intake; D005260:Female; D007225:Infant Food; D008297:Male; D010215:Papio / Q000378:metabolism*; D012737:Sex Factors