Phenylacetic acid production by Bacteroides gingivalis from phenylalanine and phenylalanine-containing peptides.
Phenylacetic acid production and growth of Bacteroides gingivalis were directly proportional to the trypticase content of the medium. L-Phenylalanine enhanced phenylacetic acid production; 5 mg L-phenylalanine per millilitre stimulated maximum production of phenylacetic acid. Peptides (2-4 amino acids) containing L-phenylalanine also stimulated phenylacetic acid production as did phenylpyruvic acid. Resting cell suspensions of B. gingivalis also produced phenylacetic acid when incubated aerobically in the presence of L-phenylalanine and phenylpyruvic acid. Hydrocinnamic acid (3-phenylpropionic acid) and phenyllactic acid were also produced by resting cell suspensions. Our results suggest that L-phenylalanine and phenylpyruvic acid are both precursors to phenylacetic acid.
D001439:Bacteroides / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D007700:Kinetics; D010455:Peptides / Q000494:pharmacology*; D010648:Phenylacetates / Q000378:metabolism*; D010649:Phenylalanine / Q000031:analogs & derivatives / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D010455:Peptides; D010648:Phenylacetates; D010649:Phenylalanine; C025136:phenylacetic acid