[Changes in the permeability of the blood-brain barrier after combined exposure to gamma-radiation and a modified gas medium].
An equation was obtained representing the time of penetration of acid fuchsin into the mouse brain as a function of: (i) radiation dose given to head, (ii) radiation dose given to body, and (iii) per cent of oxygen in a gas medium during exposure. Within the dose range from 1,29 to 2.58 C/kg, irradiation of the body increased the permeability of hematoencephalic barrier more significantly than irradiation of the head. A modifying action of hyperoxia and 8% hypoxic hypoxia was more pronounced with irradiation of the head.
D000818:Animals; D001812:Blood-Brain Barrier / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D051379:Mice; D008954:Models, Biological; D010100:Oxygen / Q000502:physiology*; D011833:Radiation Injuries, Experimental / Q000503:physiopathology*
D010100:Oxygen
Izmeneniia pronitsaemostu gematoéntsefaliticheskogo bar'era pri kombinirovannom vozdeĭstvii gamma-oblucheniia i izmenennoĭ gazovoĭ sredy.