Intercellular karyotypic similarity in near-diploid cell lines of human tumor origins.
Intercellular karyotypic compositions were studied in seven near-diploid cultured cell populations (including six cell lines) of human colorectal and fibrosarcoma origins. Within each population, 50-88% of cells had the same cell-line-specific karyotype. In five of these seven populations, coexisting minor cell types could readily be identified, implicating the frequent occurrence of mosaicism in transformed cell lines. Nearly 90% of these cell types showed a single chromosome loss or gain from the modal cell karyotype. Parameters that may assist in the evaluation of karyotypic diversity of a transformed cell line are discussed briefly.
D000230:Adenocarcinoma / Q000235:genetics*; D002460:Cell Line; D002871:Chromosome Banding; D003110:Colonic Neoplasms / Q000235:genetics*; D005354:Fibrosarcoma / Q000235:genetics; D006801:Humans; D007621:Karyotyping