title: [Changes in MAO activity in the rat liver after chronic exposure to cadmium and lead].
abstract: The effect of lead and cadmium on male progeny of the intoxicated Wistar rats was studied. Cadmium (5 ppm), lead (50 ppm), and combined doses of the two were administered in buffered drinking water. The activity of MAO was determined in liver homogenates of young rats at 30, 60 and 90 days of age, using a spectrophotometric method by Mc Even and Cohen with benzylamine as a substrate. In 30-day-old rats the enzyme activity decreased, the values being: Cd - 37,9%, Cd + Pb - 43.1%, Pb - 97.7%, as compared to controls. At 60 days of age the increase observed was: Pb - 100.3%, Cd - Pb - 196%, and Cd - 94.6%, while at 90 days of age the values were: Cd - 80.4%, Cd + Pb - 96.5%, and Pb - 122.7%.
mesh_terms: D000375:Aging; D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D007854:Lead / Q000633:toxicity*; D008099:Liver / Q000201:enzymology*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D002104:Cadmium; D007854:Lead; D008995:Monoamine Oxidase
vernacular_title: Zmiany aktywności MAO w watrobie szczura pod wpływem przewlekłego podawania kadmu i ołowiu.