[Enhanced capture by tumor cells of liposomes prepared from autologous phospholipids].
The trapping of liposomes from native phospholipids by tumor cells was found to be 2-6 times that of egg lecithin vesicles. These differences in the level of incorporation of the two types of liposomes in the course of incubation with ascitic lymphocytic leukemia cells NKLy/LL seem to be due to the different mechanisms of their utilization. Egg lecithin liposomes are trapped via endocytosis which is not highly pronounced in these cells, whereas vesicles from target-cell phospholipids are incorporated by fusion mechanism.
D000818:Animals; D002452:Cell Count; D002459:Cell Fusion; D002478:Cells, Cultured; D004531:Eggs; D004705:Endocytosis; D007739:L Cells / Q000378:metabolism; D007945:Leukemia, Lymphoid / Q000378:metabolism*; D008081:Liposomes / Q000008:administration & dosage / Q000302:isolation & purification / Q000378:metabolism*; D051379:Mice; D010713:Phosphatidylcholines / Q000302:isolation & purification / Q000378:metabolism; D010743:Phospholipids / Q000302:isolation & purification / Q000378:metabolism*
D008081:Liposomes; D010713:Phosphatidylcholines; D010743:Phospholipids
Povyshennyĭ zakhvat opukholevymi kletkami liposom, prigotovlennykh iz autologichnykh fosfolipidov.