[3H]R05-4864 and [3H]flunitrazepam binding in kainate-lesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type.
In agreement with other workers we report increased [3H]R05-4864 binding in kainate-lesioned rat striatum. [3H]R05-4864 binding, a possible glial marker, was also increased in temporal cortex obtained post-mortem from patients with Alzheimer's disease. [3H]Flunitrazepam binding was decreased in these brain samples, possibly indicative of neuronal cell loss. It is suggested that the poor binding characteristics of [3H]R05-4864 in human brain samples may limit its usefulness in assessing gliosis.
D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D000818:Animals; D001570:Benzodiazepinones / Q000378:metabolism*; D001665:Binding Sites; D003342:Corpus Striatum / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D005260:Female; D005445:Flunitrazepam / Q000378:metabolism*; D005968:Glutamate Decarboxylase / Q000378:metabolism; D006801:Humans; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D013702:Temporal Lobe / Q000378:metabolism*; D014316:Tritium
D001570:Benzodiazepinones; D011759:Pyrrolidines; D014316:Tritium; C028513:4'-chlorodiazepam; D005445:Flunitrazepam; D005968:Glutamate Decarboxylase; D007608:Kainic Acid