Development of an improved technique for first-trimester microsampling of chorion.
Six different methods of chorion biopsy were compared and assessed in 45 patients in the first trimester of pregnancy. A total of 103 biopsies was obtained; it was found that the most reliable, accurate and safe method combined direct transcervical endoscopy with real-time ultrasound scanning, using an aspiration needle.
D001706:Biopsy / Q000379:methods; D001707:Biopsy, Needle / Q000379:methods; D002823:Chorion / Q000473:pathology*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011296:Prenatal Diagnosis / Q000379:methods*; D014463:Ultrasonography