The suppressive effect of piroxicam on autochthonous intestinal tumors in the rat.
Male Lobund strain Sprague--Dawley (SD) rats respond to single doses of methylazoxymethanol acetate (MAM) with high incidence of intestinal tumors within 5 months. Some non-steroidal anti-inflammatory drugs (NSAIDs) can block the synthesis of prostaglandins (PGs) and also interfere with tumor growth. A new class of NSAID, piroxicam, was added to the feed of MAM-treated rats. When examined 150 days later, there was a significant reduction of tumor-bearing rats and of tumors/rat compared to controls on drug-free feed; and there was no evidence of toxicity.
D000818:Animals; D001835:Body Weight; D004032:Diet; D007213:Indomethacin / Q000627:therapeutic use; D007414:Intestinal Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008746:Methylazoxymethanol Acetate; D010894:Piroxicam; D051381:Rats; D011919:Rats, Inbred Strains; D013843:Thiazines / Q000494:pharmacology / Q000627:therapeutic use*
D013843:Thiazines; D010894:Piroxicam; D008746:Methylazoxymethanol Acetate; D007213:Indomethacin