Vincristine-resistant P388 leukemia cells contain a large amount of calcium.
P388 leukemia cells resistant to vincristine contained more calcium in the cells than the parent sensitive line, especially in the form of EGTA-removable (surface-bound) calcium. Although the relationship, if any, between the high cellular calcium of resistant cells and drug-resistant phenotype is not clear, the possible implications of this result for the elucidation of the mechanisms of drug resistance are interesting.
D000818:Animals; D002118:Calcium / Q000032:analysis*; D004351:Drug Resistance; D007941:Leukemia P388 / Q000032:analysis* / Q000473:pathology; D007942:Leukemia, Experimental / Q000032:analysis*; D051379:Mice; D014750:Vincristine / Q000494:pharmacology*
D014750:Vincristine; D002118:Calcium