title: Tissue distribution and elimination of [3H]levamisole in the rat after oral and intramuscular administration.
abstract: Total radioactivity and drug concentrations were determined in plasma, organs and excreta of male rats given a single oral or intramuscular dose (7.5 mg/kg) of [3H]levamisole. The anthelmintic drug was distributed mostly within the digestive contents after oral administration and in kidneys and liver after intramuscular injection. The parent drug accounted only for 32 to 45% of total radioactivity in plasma and it appeared metabolized in both urine and bile. The urine (0-72 h) contained 68-78% of the radioactive dose, as parent drug and other tritiated materials. The 4-hydroxylation of levamisole did not represent a major metabolic pathway of the drug in the rat.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001646:Bile / Q000378:metabolism; D004064:Digestive System / Q000378:metabolism; D007273:Injections, Intramuscular; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D007978:Levamisole / Q000008:administration & dosage / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
chemical_list: D007978:Levamisole