[Immunohistochemical characteristics of breast cancer after radiation treatment].
Histological and immunohistochemical examination of the tumorous tissue from 45 breast cancer patients after surgery (14) and combined treatment (31) was performed. Using direct Coons method the localization of immune complexes and immunoglobulins of the main classes (G, A, M) was revealed. Deposits of immune complexes including immunoglobulins of different classes were found in 8 patients of the 1st group and 22 patients of the 2nd group. Immune complexes were mostly localized extracellularly in the stroma. After irradiation extensive deposit and more intense fluorescence of immune complexes in the stroma of a tumor, lumpy in the walls of the major vessels were observed. In the tumor parenchyma of breast cancer patients before irradiation, immune complexes were found on the cytolemmas of cancer cells and on the surface of cancer complexes, after irradiation on the preserved cancer complexes in the form of small foci. It is assumed that immune complexes and immunoglobulins of different classes related to breast cancer epithelial cells, block the immunological interaction of T lymphocytes with cancer cells. The suppression effect of radiotherapy on tumor cell receptor activity has been shown that is not only of theoretical but also of practical interest.
D000936:Antigen-Antibody Complex / Q000032:analysis; D001943:Breast Neoplasms / Q000276:immunology / Q000378:metabolism* / Q000532:radiotherapy; D004848:Epithelium / Q000276:immunology / Q000378:metabolism; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008408:Mastectomy; D011879:Radiotherapy Dosage
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M
Immunogistokhimicheskaia kharakteristika raka molochnoĭ zhelezy posle luchevogo lecheniia.