Drug latentiation of isoxsuprine: synthesis and preliminary pharmacological activities of four monoesters.
Four new esters (1 b-e) involving the phenolic group of isoxsuprine have been prepared. Preliminary pharmacological evaluation showed that the pivaloyl ester (1 e) (LR693) lowers blood pressure values more gradually than isoxsuprine with a longer-lasting effect. This compound was selected for further assessment as a long-acting peripheral vasodilator.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D007556:Isoxsuprine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains
D007556:Isoxsuprine; D009638:Norepinephrine