Fusidane antibiotics produced by dermatophytes.
Isolates of Microsporum canis, Microsporum gypseum and Epidermophyton floccosum were observed to produce antibacterial activities under cross-resistance to fusidic acid. The activity from E. floccosum was shown to be due to fusidic acid, diketofusidic acid and 3-ketofusidic acid. Possible contributions of these antibiotics to microbial interaction during dermatophytosis is discussed.
D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D003883:Arthrodermataceae / Q000254:growth & development*; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D005672:Fusidic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D008864:Microsporum / Q000254:growth & development*; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D005672:Fusidic Acid