Surface antigens of murine hemopoietic stem cells. VIII. Antisera define lineage antigens held in common between granulocyte-macrophage cells and between lymphoid cells.
The cell-lineage model of hemopoietic cell differentiation has been further investigated by detailed absorption analysis of the anti-stem cell activity in rabbit antisera against mouse hemopoietic cells. Of seven differentiated hematopoietic cells tested, platelets alone absorbed the anti-stem cell activity in anti-platelet serum. Thymocytes and B-lymphocytes absorbed all of the anti-stem cell activity in antithymocyte serum whereas other nonlymphocytic cells showed only partial absorbing ability. Macrophages and granulocytic cells absorbed most of the anti-stem cell activity in antimacrophage serum and antineutrophil serum whereas other cell types showed little or no absorbing capacity. Antisera against a cloned mast cell precursor line showed partial cell lineage activity whereas anti-sera against eosinophils and B-lymphocytes showed no evidence of cell lineage activity. A detailed model of cell lineage antigens on hemopoietic cells is presented.
D000818:Animals; D000954:Antigens, Surface / Q000032:analysis*; D002454:Cell Differentiation; D002460:Cell Line; D005260:Female; D006098:Granulocytes / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D007106:Immune Sera; D008214:Lymphocytes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008297:Male; D051379:Mice; D011817:Rabbits
D000954:Antigens, Surface; D007106:Immune Sera