Myopathy and hypersensitivity to phenytoin.
A 19-year-old man with a generalized seizure disorder was treated with phenytoin. A hypersensitivity reaction was marked by hepatitis, severe myalgia, proximal arm weakness, and high serum creatine kinase. Biopsy was diagnostic of myopathy. Patients demonstrating abnormalities of immune responsiveness may best be managed by use of an alternative anticonvulsant.
D000328:Adult; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D008297:Male; D009220:Myositis / Q000139:chemically induced*; D010672:Phenytoin / Q000009:adverse effects*; D013226:Status Epilepticus / Q000188:drug therapy
D010672:Phenytoin