An evaluation of recently developed antibiotics.
A number of newer antibiotics, broad-spectrum penicillins and cephalosporins, have been evaluated against Gram-negative rods. The organisms were selected for multi-resistance and transferable resistance factors. None of the broad-spectrum penicillins was much use against most of the organisms. Ceftriaxone, cefotaxime, latamoxef (moxalactam) and N-formimidoyl thienamycin were all highly effective against most multi-resistant Gram-negative bacilli; cefoperazone being inferior to them. Enterobacter and Serratia strains were relatively resistant to all the agents mentioned and against Acinetobacter only N-formimidoyl thienamycin showed much activity. Thus, use of these drugs may increase the proportion of infections due to organisms such as Serratia or Acinetobacter.
D000150:Acinetobacter / Q000187:drug effects; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002511:Cephalosporins / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D004755:Enterobacteriaceae / Q000187:drug effects*; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D002511:Cephalosporins