Suppression of an ethanol withdrawal syndrome in rats by butyrate, lactate and beta-hydroxybutyrate.
Butyrate, lactate and beta-hydroxybutyrate, compounds which may be elevated in blood of ethanol dependent rats and substrates of the cerebral small-pool Krebs-cycle, were tested for their ability to suppress an ethanol withdrawal syndrome. Male Sprague-Dawley rats were rendered physically dependent on ethanol by intragastric administration of ethanol at a dosage of 9 to 15 grams per kilogram per day over a 4-day period. Oral administration of a mixture of butyrate, lactate and beta-hydroxybutyrate was effective in suppressing the tremulous component of the ethanol withdrawal syndrome.
D020155:3-Hydroxybutyric Acid; D000437:Alcoholism; D000818:Animals; D002087:Butyrates / Q000627:therapeutic use*; D020148:Butyric Acid; D002952:Citric Acid Cycle; D006801:Humans; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D007773:Lactates / Q000627:therapeutic use*; D019344:Lactic Acid; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy*
D002087:Butyrates; D006885:Hydroxybutyrates; D007773:Lactates; D020148:Butyric Acid; D019344:Lactic Acid; D020155:3-Hydroxybutyric Acid