title: Towards fully objective evoked response audiometry.
abstract: The amplitude spectra of the auditory brainstem potentials evoked by free-field stimuli revealed significant differences from the corresponding spectra of pre-stimulus records. This was most marked for low order harmonics and in response to high intensity stimuli. In general, however, the shape of the amplitude spectrum for pre-stimulus and post-stimulus epochs was similar and the magnitude of the differences between corresponding harmonics became progressively smaller as stimulus intensity was reduced. Given that the spectrum of each coherent grand average is a function of the amplitude and phase spectra of the response ensemble, these were separately examined. Ensemble mean amplitude of individual harmonics diminished with stimulus intensity while their phases became progressively less aggregated. Phase standard deviation, used as a parameter of this aggregation, was found to change more systemically with stimulus intensity than ensemble mean amplitude. Phase standard deviation values for threshold responses were generally significantly smaller than corresponding harmonics obtained from sub-threshold responses. By contrast the amplitude differences between populations of threshold and sub-threshold responses were generally non-significant. These findings suggested that fully objective methods of threshold determination might more successfully be based on ensemble phase measures rather than amplitude measures.
mesh_terms: D000818:Animals; D001299:Audiometry / Q000592:standards*; D001300:Audiometry, Evoked Response / Q000379:methods / Q000592:standards*; D001309:Auditory Threshold; D006168:Guinea Pigs; D006801:Humans