[Infectious activity of cell fractions isolated from the brain of mice with scrapie].
The agent of scrapie was found to induce clinically similar diseases in BALB/c and NIH mice but differing in the duration of the incubation period (155-180 days and 110-140 days, respectively) and pathomorphological manifestations. Differentiated examinations of a brain cell pool from mice with scrapie revealed more infectious activity not neutralized with nucleases and pronasa in membrane-free cell fractions than in fractions of slowly sedimenting membranes.
D000818:Animals; D001921:Brain / Q000382:microbiology* / Q000648:ultrastructure; D002458:Cell Fractionation; D004195:Disease Models, Animal; D051379:Mice; D008807:Mice, Inbred BALB C; D009940:Organoids / Q000382:microbiology; D012608:Scrapie / Q000209:etiology* / Q000382:microbiology / Q000473:pathology; D012756:Sheep; D013997:Time Factors
Infektsionnaia aktivnost' fraktsiĭ kletok, vydelennykh iz mozga mysheĭ, bol'nykh skrepi.