The effects of long-term malathion or diazinon ingestion on the activity of hepatic synthesized clotting factors.
Female Sprague-Dawley rats were placed on a drinking solution of 1 ppm Diazinon or malathion dissolved in water for 6 months. At the conclusion of the experiment liver tissue and plasma were examined. Clotting studies included the prothrombin time (PT), partial thromboplastin time (APTT), fibrinogen, and factors II, V, VII, X, plus the platelet count. Hepatic morphology, basically hepatocyte degeneration, was altered by malathion while diazinon had no notable effect. Likewise, malathion prolonged both the PT and APTT, the only changes in clotting activity.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001779:Blood Coagulation Factors / Q000096:biosynthesis*; D003976:Diazinon / Q000633:toxicity*; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008294:Malathion / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D001779:Blood Coagulation Factors; D007306:Insecticides; D008294:Malathion; D003976:Diazinon