gamma-Butyrolactone effects on behavior induced by dopamine agonists.
gamma-Butyrolactone (GBL) potently inhibits stereotyped behavior induced by indirect (amphetamine and methylphenidate) and direct (apomorphine) dopamine agonists. Amphetamine induces a dose-response partial reversal of the GBL effect. The GABA antagonist, bicuculline, only partially reverses the GBL inhibition of apomorphine activity, indicating that GBL may be acting through mechanisms in addition to effects on GABA.
D015107:4-Butyrolactone / Q000494:pharmacology*; D000661:Amphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D001058:Apomorphine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D001640:Bicuculline / Q000494:pharmacology; D005663:Furans / Q000494:pharmacology*; D018756:GABA Antagonists; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D005663:Furans; D018756:GABA Antagonists; D011954:Receptors, Dopamine; D008774:Methylphenidate; D005680:gamma-Aminobutyric Acid; D000661:Amphetamine; D001058:Apomorphine; D015107:4-Butyrolactone; D001640:Bicuculline