Initial impressions of dazoxiben in the treatment of the ischaemic limb.
1 Dazoxiben, a selective thromboxane synthetase inhibitor, which is active after oral administration, has been used to treat eight patients with severe peripheral vascular disease associated with ischaemic rest pain. 2 Patients were selected for treatment on the basis that amputation was the only alternative procedure. 3 Three of eight patients are well and pain-free 1, 7 and 11 months after initially receiving the drug and have not required amputation. 4 Dazoxiben may prove useful in the treatment of peripheral vascular disease.
D000328:Adult; D000368:Aged; D005121:Extremities / Q000098:blood supply*; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D007511:Ischemia / Q000188:drug therapy*; D008875:Middle Aged; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D010146:Pain / Q000188:drug therapy; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
D007093:Imidazoles; C029166:dazoxiben; D010088:Oxidoreductases; D013930:Thromboxane-A Synthase