Pharmacological studies of a series of dermorphin related tetrapeptides.
The activity pattern of 8 dermorphin related tetrapeptides was determined in guinea-pig ileum and mouse vas deferens bioassays. Naloxone was a powerful antagonist of all compounds in both preparations. Moreover the biological activities of the test compounds were correlated in a statistically significant way to the lipophilic character of the C-terminal substituents.
D000818:Animals; D004558:Electric Stimulation; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology*; D018847:Opioid Peptides; D013329:Structure-Activity Relationship; D014649:Vas Deferens / Q000187:drug effects
D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin