New form of familial Parkinson-dementia syndrome: clinical and pathologic findings.
We studied a family in which three siblings had a syndrome characterized by parkinsonism features, mental deterioration, pyramidal signs, and abnormal eye movements beginning in the third decade. The pathology resembled that of progressive supranuclear palsy or the Parkinson-dementia complex of Guam, but these were excluded by the clinical presentation. This syndrome appears to be a new entity.
D000328:Adult; D001921:Brain / Q000473:pathology; D003704:Dementia / Q000235:genetics / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D010300:Parkinson Disease / Q000235:genetics / Q000473:pathology*; D013577:Syndrome