The gastro-intestinal metabolism of ethanol in the rat. Effect of chronic alcoholic intoxication.
By collecting the blood coming exclusively from the stomach or intestine of rats, it has been shown that ethanol can be oxidized in the digestive mucosa on the basis of the appearance, during its absorption, of acetaldehyde and acetate. This has been shown to be the result of the action of alcohol- and aldehyde-dehydrogenases present in these tissues. The metabolic ability of these enzymes was tested after chronic alcoholic intoxication in association with various treatments with "anti-alcoholic" drugs. The modifications observed correspond to the effects of the treatments on the levels of the enzyme activities but are less clearcut in the in vivo conditions.
D000079:Acetaldehyde / Q000378:metabolism; D000085:Acetates / Q000378:metabolism; D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D000431:Ethanol / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000085:Acetates; D000431:Ethanol; D000079:Acetaldehyde