[Left ventricular hemodynamics in acute alcohol intoxication in guinea pigs].
This study was undertaken to investigate to what extent the cardiodepression of acute alcohol intoxication is dose-dependent and to assess the validity of isovolumetric and afterload parameters in the latter condition. Isovolumetric and ejection phase parameters were measured in-situ in the intact heart of the guinea pig. The diastolic and systolic pressure-volume-relationships were calculated on the basis of direct measurements obtained at control conditions and during acuta alcohol intoxication at blood alcohol concentrations (BAC) of 160 and 280 mg/100 ml, respectively. Cardiodepression was dose-dependent; left ventricular isovolumetric pressure fell 13% at a BAC of 280 mg/100 ml, maximal rate of pressure rise (dp/dt max) decreased 33%. The changes in afterload parameters were less consistent: there was an increase in left ventricular isovolumetric pressure and dp/dt max in the group with BAC of 160 mg/100 ml, but both of these parameters decreased at BAC levels of 280 mg/100 ml. Stroke volume and preload decreased comparably in both groups. The divergent pattern of induced hemodynamic alterations may be due to peripheral effects of ethanol and/or counter-regulatory adrenergic mechanisms. The mortality rate associated with BAC of 160 mg/100 ml was 55% and that of 280 mg/100 ml was 75%.
D000435:Alcoholic Intoxication / Q000401:mortality / Q000503:physiopathology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage / Q000097:blood; D006168:Guinea Pigs; D006352:Heart Ventricles / Q000503:physiopathology*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D013318:Stroke Volume
D000431:Ethanol
Linksventrikuläre Hämodynamik bei der akuten Alkoholintoxikation des Meerschweinchens.