title: Comparison of gas chromatographic--electron-capture detection and high-performance liquid chromatography for the determination of butofilolol in biological fluids.
abstract: Two selective and sensitive methods for the quantitative analysis of butofilol in human plasma and urine are discussed. The first method is a gas chromatographic assay with electron-capture detection using extraction with toluene, several clean-up procedures and derivatization. The second method is based on high-performance liquid chromatography and a single extraction with dichloromethane. The two assay methods were applied to the determination of the same human plasma samples after administration of a single, oral 200-mg dose of butofilolol. A good correlation between the results (inter-laboratory comparison) is obtained, validating both techniques.
mesh_terms: D002849:Chromatography, Gas / Q000379:methods; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D011412:Propanolamines / Q000032:analysis* / Q000097:blood
chemical_list: D011412:Propanolamines; C036631:butofilolol