[Androgen induction of specific estrogen-binding protein of rat liver: relationship between the stage of ontogenesis and various endocrine factors].
A new modification of specific estrogen-binding protein (SEBP) assay in the liver was used to measure the content of this protein at different stages of ontogenesis in male and female rats after administration of testosterone propionate (TP). It was shown that liver capability to form SEBP could be initially programmed by androgens. The crucial period of the SEBP-determining action of androgens in females is not restricted, since potential capability of androgens of primary induction of SEBP may be realized both neonatally and in the course of pubertation. The emergence of SEBP in the liver of males may be the result of natural pre(neo)natal androgenization. Androgens do not play any decisive role in the control of the level of induced SEBP, inasmuch the content of SEBP in the liver of non-pubertal and pubertal males does not appreciably change after TP administration but grows with pubescence. SEBP is capable of long-term existence in the absence of androgens. The presence of the ovaries produces an inhibitory effect on the level of androgen-induced SEBP and the time of its existence after TP discontinuation. Hypophysectomy does not provoke SEBP emergence in pubertal intact and ovariectomized females but prevents its induction with androgens. Adrenal- and thyroectomy produce no influence on the SEBP-programming effect of TP or promote its spontaneous appearance in the same groups of female rats.
D000375:Aging; D000818:Animals; D002369:Castration; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000378:metabolism*; D008297:Male; D010053:Ovary / Q000502:physiology; D051381:Rats; D012738:Sex Hormone-Binding Globulin / Q000096:biosynthesis*; D012741:Sexual Maturation; D013739:Testosterone / Q000502:physiology*
D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D004958:Estradiol
Induktsiia androgenami osobogo estrogensviazyvaiushchego belka pecheni krys: zavisimost' ot stadii ontogeneza i riada endokrinnykh faktorov.