Testing genetic models in populations which contain pedigree errors.
In a genetic analysis of a polymorphic system, differences between the observed type of an individual and that expected from the parental types can arise either from an incorrect model or from pedigree errors. Such pedigree errors can cause severe difficulties in studies of the mode of inheritance of a novel polymorphic system. A method is proposed which overcomes the problem by including sire and dam error rates explicitly in the genetic model. The error rates are estimated by maximum likelihood, and likelihood ratio tests used to compare different models or estimates from different data sets. The proposals are applied to a study of the inheritance of the bovine serum AmI amylases.
D000818:Animals; D001947:Breeding; D002417:Cattle / Q000235:genetics; D005260:Female; D007517:Isoamylase / Q000235:genetics; D008297:Male; D008957:Models, Genetic; D010375:Pedigree / Q000662:veterinary; D011110:Polymorphism, Genetic; D014168:Transferrin / Q000235:genetics
D014168:Transferrin; D007517:Isoamylase