Comparison of two continuous-flow cell separators.
Two blood processors (IBM 2997 and Fenwal CS-3000) were evaluated under similar conditions. Fifty-four leukapheresis procedures with the 2997 resulted in a mean granulocyte yield of 19.4 X 10(9) (42.5% efficiency), with a mean of 2.1 X 10(11) platelets (10.9% efficiency) per product. The CS 3000, at a whole blood flow rate of 50 ml/min, yielded a mean of 13.3 X 10(9) granulocytes (39.2% efficiency) and 4.0 X 10(11) platelets (28.5% efficiency) during 63 leukapheresis procedures. At a flow rate of 60 ml/min, the mean yields of 20 leukapheresis procedures with the CS 3000 were 14.2 X 10(9) granulocytes (30.5% efficiency) and 4.3 X 10(11) platelets (27.8% efficiency). Thirty-four plateletpheresis procedures with the 2997 yielded a mean of 3.62 X 10(11) platelets (53.12% efficiency), and 2.70 X 10(9) white cells. The mean CS-3000 yield for 88 plateletpheresis procedures was 3.15 X 10(11) platelets (49.13% efficiency) with a mean white cell content of 0.67 X 10(9). Granulocyte yields with the 2997 were greater than those obtained with the CS-3000.
D001782:Blood Donors; D001792:Blood Platelets; D002469:Cell Separation / Q000295:instrumentation*; D006801:Humans; D007937:Leukapheresis / Q000009:adverse effects / Q000295:instrumentation*; D010292:Paresthesia / Q000209:etiology; D010956:Plasmapheresis / Q000295:instrumentation