Chromosomal localization of the human c-fms oncogene.
A molecular probe was prepared with specificity for the human cellular homologue of transforming sequences represented within the McDonough strain of feline sarcoma virus (v-fms). By analysis of a series of mouse-human somatic cell hybrids containing variable complements of human chromosomes it was possible to assign this human oncogene, designated c-fms, to chromosome 5. Regional localization of c-fms to band q34 on chromosome 5 was accomplished by analysis of Chinese hamster-human cell hybrids containing as their only human components, terminal and interstitial deleted forms of chromosome 5. The localization of c-fms to chromosome 5 (q34) is of interest in view of reports of a specific, apparently interstitial, deletion involving approximately two thirds of the q arm of chromosome 5 in acute myelogenous leukemia cells.
D000818:Animals; D001483:Base Sequence; D002415:Cats; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D002874:Chromosome Mapping; D002877:Chromosomes, Human / Q000032:analysis*; D003001:Cloning, Molecular; D006801:Humans; D006822:Hybrid Cells / Q000378:metabolism; D051379:Mice; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D012190:Retroviridae / Q000235:genetics