title: [Familial vesicoureteral reflux].
abstract: Between August 1979 and January 1983, 43 cases of primary vesicoureteral reflux were treated in our hospital. Among them 9 cases of 4 families occurred familially. They were all siblings: 3 boys and 6 girls aged between 2 years and 10 years. Five cases except for 4 probands of each sibling were discovered after aggressive prospective family study, but they had no clinical symptoms that suspected vesicoureteral reflux; one of them was found to be in a preuremic condition. The other 2 siblings were examined by a prospective family study but demonstrated no vesicoureteral reflux. Therefore, vesicoureteral reflux could be demonstrated in 5 of the 7 siblings who had been examined by a prospective family study. This rate was significantly high (71%). Discussion is made about the necessity of prospective family study to discover asymptomatic patients with vesicoureteral reflux in the family, and the literature is reviewed.
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008297:Male; D011446:Prospective Studies; D011859:Radiography; D014513:Ureter / Q000601:surgery; D001743:Urinary Bladder / Q000000981:diagnostic imaging / Q000601:surgery; D014547:Urinary Diversion; D014718:Vesico-Ureteral Reflux / Q000000981:diagnostic imaging / Q000235:genetics* / Q000601:surgery