title: Critical review of epidemiologic studies related to ingested asbestos.
abstract: Thirteen epidemiologic studies of ingested asbestos conducted in five areas of the United States and Canada were reviewed and evaluated for the definitiveness and applicability regarding the development of ambient water quality standards. One or more studies found male or female associations between asbestos in water supplies and cancer mortality (or incidence) due to neoplasms of the esophagus, stomach, small intestine, colon, rectum, gallbladder, pancreas, peritoneum, lungs, pleura, prostate, kidneys, brain, and thyroid, and also due to leukemia. Several methodologic weaknesses and limitations were found in each study, leading to the determination that no individual study or aggregation of studies exist that would establish risk levels from ingested asbestos. A binomial probability analysis of the eight independent studies suggested that, while the level of male-female agreement was generally low, the number of observed positive associations in males and females for neoplasms of the esophagus, stomach, pancreas, and prostate was unlikely to have been generated by chance factors alone, and thus, may have a biological basis related to ingested asbestos. Cancers of the small intestine and leukemia were implicated to a lesser degree in this analysis. The patterns of integrated findings for most gastrointestinal cancers were somewhat consistent with patterns observed among asbestos-exposed occupational groups, whereas the patterns found for pancreatic cancer, kidney cancer, and leukemia were not consistent.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D001194:Asbestos / Q000009:adverse effects*; D002170:Canada; D004781:Environmental Exposure; D004812:Epidemiologic Methods; D005260:Female; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000453:epidemiology* / Q000401:mortality; D012306:Risk; D012737:Sex Factors; D014481:United States; D014881:Water Supply / Q000592:standards
chemical_list: D001194:Asbestos