Bioavailability of methyl-14C CDP-choline by oral route.
In this work, the bioavailability of the 14C-methyl-labelled cytidine diphosphate choline (CDP-Choline, citicoline, Somazina), has been studied by oral route, leading to the result that it is slowly and completely absorbed, with a very low urinary and fecal elimination, thus producing maintained blood levels. The bioavailability related to oral route compared with intravenous route is practically the same.
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000008:administration & dosage / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003566:Cytidine Diphosphate Choline; D002794:Choline