title: A comparative study of centbucridine and lidocaine in dental extraction.
abstract: A randomized double-blind study comparing the efficacy and tolerability of centbucridine (0.5%) with those of lidocaine (2%) as an anaesthetic agent was conducted in the dental outpatient department on patients attending for dental extraction. One hundred and twenty patients were studied. The degree of analgesia attained with centbucridine compared well with that obtained with lidocaine. The compound was well tolerated with no significant changes in the cardiovascular parameters and no serious side-effects.
mesh_terms: D000293:Adolescent; D000328:Adult; D000609:Aminoacridines / Q000494:pharmacology*; D000766:Anesthesia, Dental; D000779:Anesthetics, Local / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D013619:Tacrine / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology*; D014081:Tooth Extraction
chemical_list: D000609:Aminoacridines; D000779:Anesthetics, Local; D013619:Tacrine; C037014:centbucridine; D008012:Lidocaine