title: Red nucleus lesions disrupt the classically conditioned nictitating membrane response in rabbits.
abstract: Sixteen rabbits received classical conditioning of the right nictitating membrane response using a tone CS and electrostimulation of the right eye as the US. Single electrocoagulating RF lesions of the medial portion of the left magnocellular red nucleus eliminated or severely reduced the previously acquired conditioned response. This finding is consistent with the idea that an essential anatomical substrate of the conditioned response includes a circuit from the cerebellum to the contralateral red nucleus which projects contralaterally in turn to pontine motoneurons mediating the defensive nictitating membrane response.
mesh_terms: D000818:Animals; D001931:Brain Mapping; D002531:Cerebellum / Q000502:physiology; D003215:Conditioning, Eyelid / Q000502:physiology*; D004292:Dominance, Cerebral / Q000502:physiology; D009046:Motor Neurons / Q000502:physiology; D009434:Neural Pathways / Q000502:physiology; D011149:Pons / Q000502:physiology; D011817:Rabbits; D012012:Red Nucleus / Q000502:physiology*