Maturational aspects of the dopaminergic system: ontogenesis of high affinity dopamine binding to neural membrane fragments of the rat brain.
High affinity binding of [3H]-dopamine was measured in membrane fractions prepared from cerebral cortex, amygdala, hypothalamus, thalamus and reticular formation of female rats aged 1 to 260 days old. [3H]-dopamine bound with approximately 30 x 10(-9) M affinity to neural membrane fractions of female brains of any age. [3H]-dopamine binding increased with age either in a sigmoid fashion, as was the case in the amygdala, hypothalamus and reticular formation, or in a parabolic fashion, as was the case in the cerebral cortex and thalamus, the adult levels being reached on the 30th and 70th day of life respectively.
D000367:Age Factors; D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001665:Binding Sites; D001921:Brain / Q000378:metabolism* / Q000648:ultrastructure; D002462:Cell Membrane / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D005260:Female; D008297:Male; D011869:Radioligand Assay; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism*
D011954:Receptors, Dopamine; D004298:Dopamine