Increased sleep following intracerebroventricular injection of the delta sleep-inducing peptide in rats.
Synthetic delta sleep-inducing peptide (DSIP) was injected intracerebroventricularly into rats in a dose of 7 nmol/kg. A significant, 20% increase in total slow wave sleep (and total sleep) was found in the DSIP-injected rats, compared to a baseline recording following a sham injection procedure. Rats injected with the Ringer solution vehicle did not change their sleep compared to their baseline recording.
D000818:Animals; D003701:Delta Sleep-Inducing Peptide; D007276:Injections, Intraventricular; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012894:Sleep Stages / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects
D009842:Oligopeptides; D003701:Delta Sleep-Inducing Peptide