Studies on tomaymycin. III. Synthesis and antitumor activity of tomaymycin analogs.
The syntheses and antitumor activity of tomaymycin analogs are described. Structural modification of such parts of tomaymycin as the ethylidenepyrrole ring, animal bond, and substituents of the benzene ring are discussed.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis* / Q000633:toxicity; D001570:Benzodiazepinones / Q000138:chemical synthesis / Q000633:toxicity; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D007202:Indicators and Reagents; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D051379:Mice; D012510:Sarcoma 180 / Q000188:drug therapy; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; D001570:Benzodiazepinones; D007202:Indicators and Reagents; C003619:tomaymycin