Induction of functional sterility in male rats by low dose Carica papaya seed extract treatment.
The result revealed that a short term administration of an aqueous extract of Carica papaya seed manifested an androgen deprived effect on the target organs and thereby caused antifertility effect in adult male albino rats. The complete loss of fertility is attributed to decline in sperm motility and alteration in their morphology as well as to reduced contractile response of the vas deferens. The androgen deprived effect of the extract led to slight alteration in the histoarchitecture and weight of the reproductive organs, mainly cauda and distal vas deferens which has been related to their greater androgen sensitivity in comparison to the other target organs and or their greatly diminished target organ response to testosterone or its metabolites. The data revealed that functional sterility could be induced in male rats by papaya extract treatment, which promises to be a potential male contraceptive.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004822:Epididymis / Q000187:drug effects; D007248:Infertility, Male / Q000139:chemically induced*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D012639:Seeds; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013737:Testis / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects
D010936:Plant Extracts