Low-resolution autoradiography in rat brain after administering labelled CDP-choline.
14C-Methyl labelled cytidine diphosphate choline (CDP-choline, citicoline, Somazina) at a dose of 10 microCi has been administered orally to rats. Half of animals were sacrificed at 5 h, and other half at 24 h after administration. Autoradiography preparations of brain were isolated according to a relevant method for optical microscopy examination. Extra- and intracellular distribution of the drug after different unlabelling times has been studied. The intracellular radioactivity was checked 24 h after administration.
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D003566:Cytidine Diphosphate Choline; D002794:Choline