The effect of piracetam on the central action of ethanol in mice and rabbits.
The effect of combined single administration of ethanol and piracetam on the rabbit EEG and on locomotor activity and ethanol sleep in mice was investigated. In addition, the effect of prolonged administration of piracetam together with ethanol on rabbit EEG and after-discharges evoked by electrical stimulation of the hippocampus was studied. The blood ethanol concentrations were also monitored. Single administration of piracetam did not change the effects of ethanol, while when given prolongly with ethanol piracetam attenuated the effects of ethanol. Piracetam did not affect the ethanol blood level.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D004347:Drug Interactions; D004569:Electroencephalography; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009043:Motor Activity / Q000187:drug effects; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D011817:Rabbits; D012890:Sleep / Q000187:drug effects; D013045:Species Specificity
D011760:Pyrrolidinones; D000431:Ethanol; D010889:Piracetam