title: Chloroquine in long-term treatment of rheumatoid arthritis.
abstract: The effect of long-term (18-70 months) chloroquine treatment 250 mg daily, in rheumatoid arthritis (RA) was studied in 20 patients. Sedimentation rates were significantly reduced, as compared to a reference group of 10 RA patients on no treatment of disease modifying anti-rheumatic drugs. Radiographical progression of the disease was low in the majority of chloroquine-treated patients but not significantly different from the finding in the patients of the reference group. Rapid radiographical progression during 2-3 years was, however, observed in 5 patients despite chloroquine treatment.
mesh_terms: D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000000981:diagnostic imaging / Q000188:drug therapy*; D001175:Arthrography; D001799:Blood Sedimentation; D002738:Chloroquine / Q000627:therapeutic use*; D005260:Female; D006441:Hemoglobin A / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D002738:Chloroquine; D006441:Hemoglobin A