Domiodol; separation of cis and trans isomers and comparison of their pharmacological activity.
Cis and trans isomers of 2-iodomethyl-4-hydroxymethyl-1,3-dioxolane (domiodol, MG 13 608) were separated by preparative GLC and prepared on a larger scale by previous resolution of an intermediate. Acute toxicity and effect on respiratory tract excretion were evaluated for domiodol and for each isomer: no significant differences were found.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004148:Dioxolanes / Q000302:isolation & purification / Q000494:pharmacology* / Q000633:toxicity; D004149:Dioxoles / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D051381:Rats; D012137:Respiratory System / Q000187:drug effects / Q000378:metabolism; D013237:Stereoisomerism
D004148:Dioxolanes; D004149:Dioxoles; C027858:domiodol