title: Results of Wratizolin treatment of selected skin diseases with particular reference to those of viral etiology.
abstract: A newly synthetized compound, p-chlorophenylamide of 3-methyl-5-benzoylaminoisothiazole-4-carboxylic acid (ITCL) was used for local treatment in 68 patients with the following skin diseases: herpes simplex, herpes zoster, eczema complicated by bacterial infection, aphthae of the mucosa. In all cases examined, a good tolerance of the drug, rapid subsidence of pathologic symptoms, mainly of inflammation, pain and edema could be seen. The drug was found to reduce markedly the duration of the disease, particularly in the case of herpes simplex and aphthae.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D000998:Antiviral Agents / Q000627:therapeutic use*; D002648:Child; D004485:Eczema / Q000188:drug therapy; D005260:Female; D006561:Herpes Simplex / Q000188:drug therapy; D006562:Herpes Zoster / Q000188:drug therapy; D006801:Humans; D007169:Impetigo / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D009824:Ointments; D012871:Skin Diseases / Q000188:drug therapy*; D012874:Skin Diseases, Infectious / Q000188:drug therapy*; D013281:Stomatitis, Aphthous / Q000188:drug therapy; D013844:Thiazoles / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D000998:Antiviral Agents; D009824:Ointments; D013844:Thiazoles; C027999:5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide