Effect of thyrotropin (TSH) treatment on the responsiveness of the thyroid gland during endotoxin shock in adult rats.
The shock-inducing dose (1.0 omg/200 g i.v.) of bacterial endotoxin (E coli 089) significantly decreased the serum levels of T4 and inhibited the T4 increasing action of thyrotropin in rats. It is suggested that the changes observed were due to the membrane damaging effect of endotoxin.
D000818:Animals; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012772:Shock, Septic / Q000097:blood / Q000503:physiopathology*; D013961:Thyroid Gland / Q000187:drug effects*; D013972:Thyrotropin / Q000494:pharmacology*; D013974:Thyroxine / Q000097:blood
D013972:Thyrotropin; D013974:Thyroxine