Oxytetracycline plasma concentrations in sheep after the administration of a polyvinylpyrrolidone formulation.
A polyvinylpyrrolidone formulation of oxytetracycline was injected intramuscularly into 5 sheep at 2 different dosages of 10 mg and 20 mg/kg body mass respectively. Plasma levels were determined. The higher dosage not only attained a higher peak value, but the concentration at 12 hours was 0.5 micrograms/ml. At the lower dosage rate a level of 0,63 micrograms/ml was recorded 32 hours after administration when that of the higher dosage rate was 1,5 micrograms/ml.
D000818:Animals; D007273:Injections, Intramuscular; D008297:Male; D010118:Oxytetracycline / Q000097:blood*; D014677:Pharmaceutical Vehicles / Q000494:pharmacology; D011205:Povidone / Q000008:administration & dosage*; D012756:Sheep / Q000378:metabolism*; D013997:Time Factors
D014677:Pharmaceutical Vehicles; D011205:Povidone; D010118:Oxytetracycline