A new member of the troponin C superfamily: comparison of the primary structures of rat oncomodulin and rat parvalbumin.
When the amino-acid sequence of the 108-residue, rat tumour calcium-binding protein, oncomodulin, was aligned with that of rat muscle parvalbumin, 55 homologous positions were found, with an additional 33 single base-pair substitutions. This extensive homology, with virtual identity of the calcium-binding domains, signalled oncomodulin to be a member of the troponin C superfamily. The presence of Cys-18 and Phe-66 in oncomodulin, plus its isoelectric point of 3.9, suggest that this tumour protein is a beta-parvalbumin, rather than a muscle alpha-parvalbumin.
D000595:Amino Acid Sequence; D000818:Animals; D002135:Calcium-Binding Proteins; D009124:Muscle Proteins; D009132:Muscles / Q000032:analysis*; D009363:Neoplasm Proteins; D010320:Parvalbumins; D051381:Rats; D011915:Rats, Inbred BUF
D002135:Calcium-Binding Proteins; D009124:Muscle Proteins; D009363:Neoplasm Proteins; D010320:Parvalbumins; C034733:oncomodulin