[Analysis of acute and chronic effects of antidepressive agents in a learned helplessness model in mice].
In experimental learned helplessness in mice determined by preliminary inavoidable aversive exposure, activity of tricyclic antidepressants (desipramine, chlorimipramine, amitryptyline), type A MAO inhibitors (pyrazidol), and atypical (zimelidine, trazodon, befuralin) antidepressants as well as that of potential antidepressants (LIS-30, DZK-153) were determined upon chronic administration. The tricyclic compounds, befuralin and DZK-153 removed learned helplessness only after 14 days of administration. The substances with a predominant serotoninomimetic action (zimelidin, trazodon in high doses, pyrazidol, LIS-30) showed high efficacy following 6 days of administration. Single administration of the substances under study did not make it possible to disclose their specific antidepressant activity.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects*; D003863:Depression / Q000188:drug therapy*; D004195:Disease Models, Animal; D004334:Drug Administration Schedule; D004924:Escape Reaction / Q000187:drug effects; D006380:Helplessness, Learned; D006801:Humans; D008297:Male; D051379:Mice; D011930:Reaction Time / Q000187:drug effects
D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic
Analiz ostrogo i khronicheskogo éffekta antidepressantov na modeli depressii povedeniia ("learned helplessness") u mysheĭ.