Correlations between skin sensitization potential and chemical reactivity for p-nitrobenzyl compounds.
Quantitative relationships between skin sensitization potential and certain physico-chemical properties of alkylating agents have been reported. This study demonstrates the correlation of the relative alkylation index (RAI), derived from the alkylation rate and lipophilicity of an alkylating agent, with a set of experimental sensitization data obtained for a series of p-nitrobenzyl compounds.
D000478:Alkylation; D000818:Animals; D002082:Butylamines / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D003877:Dermatitis, Contact / Q000209:etiology*; D006168:Guinea Pigs; D009578:Nitrobenzenes / Q000633:toxicity*; D012882:Skin Tests
D002082:Butylamines; D009578:Nitrobenzenes; C032462:n-butylamine