title: [Mutagenic action of the DNA of the highly oncogenic bovine adenovirus type 3 (BAV-3)].
abstract: The induction of mutations to the 6-mercaptopurine resistance has been studied in Chinese hamster cells after transfection with highly oncogenic bovine adenovirus type 3 DNA (BAV-3). A statistically significant increase in the yield of resistant mutants is induced by viral DNA after two days expression time. The value of induction varies from 56,12 X 10(-5) to 70,02 X 10(-5). The comparison of the mutagenic activity of DNA and the intact viral particles has revealed that the number of DNA molecules must be higher than after infection with the whole virus to obtain a similar effect.
mesh_terms: D000256:Adenoviridae / Q000235:genetics / Q000472:pathogenicity*; D000818:Animals; D002478:Cells, Cultured; D002999:Clone Cells / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D004279:DNA, Viral / Q000494:pharmacology*; D004351:Drug Resistance; D005796:Genes / Q000187:drug effects; D015122:Mercaptopurine / Q000037:antagonists & inhibitors; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D014162:Transfection / Q000187:drug effects
chemical_list: D004279:DNA, Viral; D009153:Mutagens; D015122:Mercaptopurine
vernacular_title: Mutagennoe deĭstvie DNK vysokoonkogennogo bych'ego adenovirusa tipa 3 (BAV-3).