[Ultrastructure of the spores of fungal strains, producers of fusidic acid, varying in antibiotic activity].
The nature of the fine structure of the spores of fusidic acid-producing organism changed with an increase in the antibiotic activity of its strains. Impairments in the structure of the cell coating were observed. The surface layers of the spore wall became labile, they were capable of separating, destructive impairment in the electron solid structures were detected in the spore cytoplasm, such impairments resulted in autolysis of extended areas. The lability of the surface layers of the spore wall promoted contacts between the spore cell coatings. The increased adhesive properties of the spore coatings resulted in formation of the spore "heads" typical of sporulation in highly active strains. The latter were characterized by a marked increase in the number of the spores filled with lipids and devoid of the main cell organelles and having a changed structure of the spore wall. This explained the marked decrease in the viability of the conidia of the highly active strains of the organism producing fusidic acid.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D005672:Fusidic Acid / Q000096:biosynthesis*; D008855:Microscopy, Electron, Scanning; D003904:Mitosporic Fungi / Q000378:metabolism / Q000648:ultrastructure*; D013172:Spores, Fungal / Q000648:ultrastructure
D000900:Anti-Bacterial Agents; D005672:Fusidic Acid
Ul'trastruktura spor raznykh po antibioticheskoĭ aktivnosti shtammov griba produtsenta fuzidievoĭ kisloty.