Microhaemorheological properties of binifibrate. Part I: Experimental studies.
The microhaemorheological properties of 3-pyridine carboxylic acid 2-[2-(4-chlorophenoxy)-2-methyl-1-oxopropoxy]-1,3-propanediyl ester (binifibrate, Biniwas), a hypolipidaemic and anti-arteriosclerotic drug composed of two nicotinic radicals and one clofibric radical united by glycerol, were studied. Binifibrate increased passage of a suspension of red blood cells at 80% haematocrit value through filters of 30-40 micron (Teitel's method), and erythrocyte deformability detectable by increase of flow rate through filters of pore size lesser than erythrocyte diameter (Schmid-Schönbein's method). After treatment, resistance to lysis in hypotonic solution is also augmented, indicating that microhaemorheological activity is due to modification of the elastic properties of the erythrocyte membrane.
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001809:Blood Viscosity / Q000187:drug effects*; D005260:Female; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D009539:Nicotinic Acids / Q000494:pharmacology*; D009996:Osmotic Fragility / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D000960:Hypolipidemic Agents; D009539:Nicotinic Acids; C038877:binifibrate