Arginine vasopressin suppresses oxytocin release from the superfused rat hypothalamo-pituitary complex.
The role of arginine vasopressin (AVP) in the regulation of oxytocin secretion was studied in a superfusion system of the hypothalamo-pituitary complex from cycling female rats in dioestrus of the oestrous cycle. After perfusion with Medium 199 alone at 37 degrees C for an equilibration period of 2.5 h, perfusion with Medium 199 containing 10 mU/ml AVP for 30 min caused a prompt and significant (P less than 0.05) decrease in the oxytocin level of up to 60% of that before AVP perfusion, whereas Medium 199 containing 0.1 mU/ml AVP had no effect on oxytocin efflux. This finding suggests that AVP may be involved in the regulation of oxytocin release from the hypothalamo-pituitary system.
D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D004031:Diestrus; D005260:Female; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D010121:Oxytocin / Q000378:metabolism*; D010477:Perfusion; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D001127:Arginine Vasopressin; D010121:Oxytocin