Suboptimal dietary zinc intake increases aluminum accumulation into the rat brain.
The aluminum concentration in the frontal cortex and hippocampus increased when rats were fed semi-synthetic diets containing suboptimal levels of zinc and elevated levels (1000 parts per million, ppm) of aluminum.
D000535:Aluminum / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003300:Copper / Q000494:pharmacology; D004032:Diet; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D015032:Zinc / Q000172:deficiency* / Q000494:pharmacology
D003300:Copper; D000535:Aluminum; D015032:Zinc