Naloxone-induced suppression of food intake is potentiated by neonatal administration of monosodium glutamate to mice.
The anorectic potency of naloxone and fenfluramine was evaluated in mice treated neonatally with 4 mg/g of MSG. Naloxone produced a specific and pronounced suppression of food intake in MSG-treated mice, whereas fenfluramine was equipotent in suppressing food intake for both MSG-treated and control mice. Naloxone at doses of 5, 10 and 20 mg/kg was significantly more potent in suppressing food intake in MSG-treated mice when compared to controls. Water intake, however was suppressed to a greater extent in control mice than MSG-treated mice following administration of either naloxone or fenfluramine. These results implicate endogenous opiate systems in the obesity and alterations in food intake regulation exhibited by MSG-treated mice.
D000818:Animals; D001067:Appetite Depressants; D001835:Body Weight / Q000187:drug effects; D003864:Depression, Chemical; D004326:Drinking / Q000187:drug effects; D004357:Drug Synergism; D004435:Eating / Q000187:drug effects*; D005277:Fenfluramine / Q000008:administration & dosage; D005971:Glutamates / Q000008:administration & dosage*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009270:Naloxone / Q000008:administration & dosage*; D012970:Sodium Glutamate / Q000008:administration & dosage*
D001067:Appetite Depressants; D005971:Glutamates; D005277:Fenfluramine; D009270:Naloxone; D012970:Sodium Glutamate