[Experimental combination chemotherapy with vincristine and carboquone in human ovarian cancer transplanted into nude mice].
The tumor killing effects of combination chemotherapy with vincristine (VCR) and carboquone (CQ) administrated either simultaneously or sequentially with time intervals of up to 36 hours were studied in serially transplantable human ovarian cancer (JOG-1) in nude mice. Using 3H-thymidine pulse labeling, some tumor cell kinetic parameters were estimated as 13.8 hours for Ts and 42.2 hours of Tc, respectively. The induction of partial synchronization after treating with VCR in vivo was confirmed by estimating both the labeling index and the mitotic index. Sequential treatment with VCR followed by CQ at intervals of 24 hours was the most effective anti-tumor schedule in this treatment system. This sequence of drug administration also resulted in either weight loss nor toxic death of the animals during the schedule. These results indicate that the sequential administration of VCR followed by CQ chemotherapy is strongly recommended for clinical application.
D000818:Animals; D001389:Azirines / Q000008:administration & dosage*; D002225:Carbazilquinone / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D010051:Ovarian Neoplasms / Q000188:drug therapy*; D013997:Time Factors; D014750:Vincristine / Q000008:administration & dosage*
D001389:Azirines; D002225:Carbazilquinone; D014750:Vincristine