Intramuscular and oral midazolam. Some factors influencing uptake.
Intramuscular midazolam is better absorbed than when given orally. Addition of hyaluronidase to the injection significantly increases uptake but causes a high incidence of pain at the injection site. Concurrent administration of oral midazolam and metoclopramide does not increase its uptake.
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D001569:Benzodiazepines / Q000008:administration & dosage* / Q000378:metabolism; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000494:pharmacology; D007273:Injections, Intramuscular; D008787:Metoclopramide / Q000494:pharmacology; D008874:Midazolam; D013997:Time Factors
D001569:Benzodiazepines; D006821:Hyaluronoglucosaminidase; D008787:Metoclopramide; D008874:Midazolam