title: The chromosome constitution of 1000 human spermatozoa.
abstract: Chromosomal analysis of 1000 spermatozoa from 33 normal men was performed using in vitro fertilization of zona-free golden hamster eggs. The frequency of abnormal sperm complements was 8.5%: 5.2% were aneuploid and 3.3% had a structural chromosome abnormality. The frequencies of hyperhaploid (2.4%) and hypohaploid (2.7%) sperm complements were not significantly different and all chromosome groups were represented among the aneuploid complements. The majority (22/33) of structurally abnormal complements had a chromosome break. The percentages of X and Y-bearing sperm were 53.9% and 46.1%, which is significantly different from the expected one to one ratio.
mesh_terms: D000328:Adult; D000818:Animals; D002869:Chromosome Aberrations; D006224:Cricetinae; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D007621:Karyotyping; D008297:Male; D008647:Mesocricetus; D008875:Middle Aged; D011003:Ploidies; D013094:Spermatozoa / Q000648:ultrastructure*; D014960:X Chromosome / Q000648:ultrastructure; D014998:Y Chromosome / Q000648:ultrastructure