title: Cholinolytic activity of 3-hydroxyquinuclidyl-1-phenyl-1-cyclohexyl-1-carboxylate hydrochloride (ANC-821).
abstract: Compound ANC-821 antagonized the action of acetylcholine on the rat ileum, counteracted oxotremorine-induced salivation and convulsions and pilocarpine-induced salivation in mice and abolished acetylcholine-induced bronchospasm in rats. This shows that ANC-821 possesses cholinolytic properties, but it is much less potent in this respect than atropine.
mesh_terms: D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects; D004562:Electrocardiography; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D010095:Oxotremorine / Q000037:antagonists & inhibitors; D010276:Parasympatholytics / Q000633:toxicity; D010862:Pilocarpine / Q000037:antagonists & inhibitors; D011812:Quinuclidines / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D010276:Parasympatholytics; D011812:Quinuclidines; D010862:Pilocarpine; C038895:ANC 821; D010095:Oxotremorine; D001285:Atropine; D000109:Acetylcholine