Hb S Mobile: a new genetic combination.
The genetic combination of Hb Mobile (beta 73 Asp replaced by Val) and Hb S (beta 6 Glu replaced by Val) was found in a healthy black man whose hemolysate resembles that of Hb S electrophoretically. His mother and sister have Hb AS; the father and brother have Hb A Mobile. No clinical nor hematologic abnormalities were detected in any member of the family. A slightly decreased oxygen affinity associated with Hb Mobile appears to have no clinical significance. Simple methods of differentiating Hb Mobile S from the electrophoretically similar but clinically severe Hb SD Los Angeles are described.
D000293:Adolescent; D000368:Aged; D044383:Black People; D001797:Blood Protein Electrophoresis; D005260:Female; D006441:Hemoglobin A / Q000032:analysis / Q000235:genetics; D006451:Hemoglobin, Sickle / Q000032:analysis / Q000235:genetics*; D006455:Hemoglobins, Abnormal / Q000032:analysis / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged
D006451:Hemoglobin, Sickle; D006455:Hemoglobins, Abnormal; C026449:hemoglobin Mobile; D006441:Hemoglobin A