[Pharmacokinetics of 14C-isosorbide dinitrate after administration in various sustained-release formulations].
To study the influence of various in vitro release rates and of coadministration with food on bioavailability of isosorbide dinitrate (ISDN; isoket retard 40) and its mononitrate metabolites from sustained-release formulations the pharmacokinetics of two experimental batches of tablets with different release rates containing 40 mg 14C-ISDN each were studied in six human volunteers. One of the formulations was not only administered after fasting but aslo with a standard meal. In all cases approx. 80% of the administered radioactivity were recovered in the urine and 5% in the faeces during 3 days demonstrating extensive absorption. Any influence of release rates or food on absorption rates could not be detected. When administered after fasting either formulation was bioequivalent. Coadministration of a meal enhanced ISDN plasma levels in some subjects although no statistically significant difference in extent of bioavailability was observed. Availability of the mononitrates was unaffected by food.
D000328:Adult; D003692:Delayed-Action Preparations; D005243:Feces / Q000032:analysis; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage* / Q000378:metabolism; D007700:Kinetics; D008297:Male; D011786:Quality Control
D003692:Delayed-Action Preparations; D007548:Isosorbide Dinitrate
Pharmakokinetik von 14C-Isosorbiddinitrat nach verschiedenen Retardformulierungen.