title: Effects on the peripheral nervous system of workers' exposure to carbon disulfide.
abstract: An evaluation of the effects of occupational exposure to carbon disulfide was performed in a sample of 156 male viscose rayon workers. A composite group of 233 workers drawn from two other artificial fiber plants located on the same premises as the rayon plant was used for comparison. Effects of CS2 on the peripheral nervous system (PNS) were evaluated in ulnar and peroneal nerves using measurements of maximum motor nerve conduction velocity (MCV) and distal latency; and sensory conduction velocity (SCV) in the sural nerve. Self-reported symptoms related to PNS disorders were also obtained from each study participant. Industrial hygiene records showed the rayon workers to have had CS2 exposures that generally had not exceeded 20 ppm. The overall mean number of years of CS2 exposure was 12.1 years (+/- 6.9 S.D.). The viscose rayon workers were divided prior to the study into three groups according to historical mean CS2 levels calculated for job titles, and area and personal CS2 samples were obtained during the conduct of the study to characterize each job. For these three groups the median CS2 levels were measured to be 1.0, 4.1 and 7.6 ppm. The comparison group's median CS2 level approximated 0.2 ppm. Results showed CS2-exposed workers to have small but statistically significant (p less than .05) reductions in sural SCV and peroneal MCV. Other neurophysiological measures consisting of distal latency, residual latency, and muscle or nerve action potential amplitudes showed no significant differences between study groups. A reduction in the ratio of amplitudes of muscle action potentials obtained from peroneal nerve stimulation was significant (p less than .05). Reductions in the peroneal nerve MCV were found to be related, in a dose response sense, to workers' cumulative exposure to CS2. No increase attributable to CS2 was found in the prevalence of symptoms related to PNS disorders. The results from this study generally agree with similar findings from Finland, Sweden and Italy, but at CS2 exposure levels lower than those previously reported for occupational exposure.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000328:Adult; D002246:Carbon Disulfide / Q000633:toxicity*; D002482:Cellulose; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure; D006801:Humans; D008297:Male; D008452:Maximum Allowable Concentration; D009431:Neural Conduction / Q000187:drug effects; D010543:Peroneal Nerve / Q000503:physiopathology*; D011930:Reaction Time / Q000187:drug effects; D013127:Spinal Nerves / Q000503:physiopathology*; D013497:Sural Nerve / Q000503:physiopathology*; D013783:Textile Industry; D013997:Time Factors; D014459:Ulnar Nerve / Q000503:physiopathology*
chemical_list: D002482:Cellulose; C012024:rayon, purified; D002246:Carbon Disulfide