[Effect of naloxone in traumatic shock].
Experiments on rabbits were made to examine the effect of naloxone, a specific antagonist of opiates and endogenous opioid peptides, on traumatic shock. Naloxone (0.1-1.0 mg/kg) injected intravenously 2-15 minutes after trauma produced no effect on the arterial pressure and the heart rate. As compared with control animals, the lifespan of animals with trauma decreased. It is suggested that endogenous opioid peptides may play a protective and adaptive role in the torpid phase of traumatic shock.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D009270:Naloxone / Q000627:therapeutic use*; D011817:Rabbits; D012119:Respiration / Q000187:drug effects; D012774:Shock, Traumatic / Q000188:drug therapy*
D009270:Naloxone
Deĭstvie naloksona pri travmaticheskom shoke.