title: Design and pharmacokinetic application of an analog computer program (MULS) for multiple dose simulation.
abstract: MULS is a simulation program developed on an analog computer equipped with logic elements. It is designed for multiple dose simulation of commonly encountered dosing schemes: equal or unequal dosing intervals, bolus and/or constant rate drug input, with or without loading dose. Appropriate pharmacokinetic models are defined independently of dosage regimen selection. The program can be used in routine operation for visualization of drug accumulation and optimum dosage regimen. Examples of the program outputs are presented.
mesh_terms: D003201:Computers; D007700:Kinetics; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000008:administration & dosage* / Q000378:metabolism; D012984:Software
chemical_list: D004364:Pharmaceutical Preparations