Pharmacokinetic properties of the new cephalosporin antibiotic HR 810 in animals.
The pharmacokinetic profile of HR 810 was investigated in mice, rats, rabbits, dogs and monkeys. High blood resp. serum levels were achieved following subcutaneous, intramuscular and intravenous injection, and half-lives ranged from 20 min in mice to 89 min in rabbits. The compound was well distributed in the body and penetrated tissues and body fluids to a high degree. While large amounts of the antibiotic were recovered in the animals' urine, the recovery rate in bile was very low. These good pharmacokinetic properties, together with its high antibacterial activity, open the way for the evaluation of HR 810 in humans.
D000818:Animals; D002511:Cephalosporins / Q000378:metabolism*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007700:Kinetics; D008251:Macaca; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D014018:Tissue Distribution; D000097572:Cefpirome
D002511:Cephalosporins; D000097572:Cefpirome