Bacterial modulation of the cellular immune response in mice. I. The course of lymphocytic choriomeningitis virus infection in Bordetella pertussis vaccine pretreated mice with physiological thymus involution.
The cellular immune response to lymphocytic choriomeningitis virus infection was found to be normal in 6-month-old mice with physiological thymus involution, while it was reduced in 18-month-old mice. The Bordetella pertussis vaccine elicited immunosuppression in 6-month-old mice with normal immunological responsiveness, while it failed to affect the physiologically diminished cellular immune response in 18-month-old mice. The extent of immunosuppression elicited by the vaccine changed parallel to its concomitant spleen hypertrophy inducing effect.
D000367:Age Factors; D000818:Animals; D005260:Female; D006984:Hypertrophy; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D008216:Lymphocytic Choriomeningitis / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size / Q000187:drug effects; D010567:Pertussis Vaccine / Q000276:immunology*; D013154:Spleen / Q000473:pathology; D013950:Thymus Gland / Q000502:physiology*; D014611:Vaccination
D010567:Pertussis Vaccine