Nicotine potentiates sodium pentobarbital but not ethanol induced sleep.
Nicotine potentiates, in a dose dependent manner, the sleep time induced by sodium pentobarbital but not by ethanol. Mecamylamine, a nicotinic receptor antagonist, blocked the nicotine induced increase in sleep time. Atropine itself reduced sleep time but did not change the nicotine effect. It is hypothesized that the central and the peripheral nicotinic receptors play an important role in potentiating sodium pentobarbital induced sleep time.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D000431:Ethanol / Q000494:pharmacology*; D008464:Mecamylamine / Q000494:pharmacology; D051379:Mice; D008815:Mice, Inbred Strains; D009538:Nicotine / Q000494:pharmacology*; D010424:Pentobarbital / Q000494:pharmacology*; D011978:Receptors, Nicotinic / Q000187:drug effects; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors
D011978:Receptors, Nicotinic; D000431:Ethanol; D008464:Mecamylamine; D009538:Nicotine; D001285:Atropine; D010424:Pentobarbital