Modulation of plasminogen activator activity in human skin fibroblasts infected with mycoplasmas.
Secreted and cell-associated plasminogen activator was measured in human skin fibroblasts infected with mycoplasmas. The infected fibroblasts exhibited significantly higher levels of secreted and cell-associated plasminogen activator activity compared to uninfected skin fibroblasts. Subconfluent infected fibroblasts had increased plasminogen activator activity compared to confluent infected fibroblasts. Plasminogen activator may be important in tissue destruction in disease states in which mycoplasma infection has been implicated.
D002478:Cells, Cultured; D003240:Connective Tissue Diseases / Q000209:etiology; D005347:Fibroblasts / Q000378:metabolism / Q000382:microbiology*; D006801:Humans; D008297:Male; D009174:Mycoplasma / Q000502:physiology*; D009175:Mycoplasma Infections / Q000150:complications; D010960:Plasminogen Activators / Q000378:metabolism*
D010960:Plasminogen Activators