Non-MHC alloantigenic system in pigs (SLC) detected by leucoagglutination.
Two cell membrane leucocyte alloantigens were detected in pigs by simple direct agglutination tests. Family studies showed that the locus controlling these antigens was not identical, or in close linkage, with the SLA major histocompatibility complex, SLB leucocyte locus or with the A, E, and N blood group loci. In the studied population, the locus termed SLC (Swine Leucocyte C locus) has two alleles controlling mutually exclusive antigens SLC-1 and SLC-2. The frequency of SLC1 and SLC2 alleles is 0.10 and 0.90, respectively. The antigens have not been detected on erythrocytes and thrombocytes but are well determined on granulocytes, peritoneal macrophages, mononuclears from different sources (thymus, spleen, bone marrow, lymph nodes) and enriched T and B cells from peripheral blood.
D000372:Agglutination Tests; D000818:Animals; D000954:Antigens, Surface / Q000235:genetics*; D006098:Granulocytes / Q000276:immunology; D006649:Histocompatibility Antigens / Q000235:genetics*; D007519:Isoantigens / Q000235:genetics*; D008214:Lymphocytes / Q000276:immunology; D008285:Major Histocompatibility Complex; D009000:Monocytes / Q000276:immunology; D013552:Swine / Q000235:genetics / Q000276:immunology*
D000954:Antigens, Surface; D006649:Histocompatibility Antigens; D007519:Isoantigens