Transplants of olfactory mucosa in the anterior chamber of the eye: morphology, electrophysiology and biochemistry.
The olfactory mucosa from neonatal rats was transplanted into the anterior chamber of the eye. By 6-8 weeks after transplantation, morphological analysis showed the presence of olfactory sensory neurons in the grafts. The summated receptor potentials evoked by n-amyl acetate and camphor had the peak amplitude of about three times less and the duration of response of about 8-10 times more than those from normal olfactory epithelium. 6 h after beta-[3H]-alanine administration into the anterior chamber, more than 70% of the radioactivity was present in the carnosine fraction. This indicates that carnosine synthetase is present in the grafts. The presented data suggest that the grafts contain mature olfactory sensory neurons.
D000818:Animals; D000831:Animals, Newborn; D005071:Evoked Potentials; D005260:Female; D008297:Male; D009831:Olfactory Mucosa / Q000294:innervation / Q000502:physiology / Q000637:transplantation*; D010453:Peptide Synthases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012903:Smell / Q000502:physiology*
D010453:Peptide Synthases; C019844:carnosine synthetase