Thermoregulatory effects of D-met2-pro5-enkephalinamide.
Changes elicited in the body temperature by subcutaneous injection of the synthetic D-met2-pro5-enkephalinamide (D-met2-pro5-EA) were studied in CFY rats. D-met2-pro5-EA in doses of 8, 20 and 40 mg/kg caused hyperthermia. If the animals were restrained, this hyperthermic effect was attenuated. Ten mg/kg naloxone completely prevented the elevation of body temperature. Previous administration of 300 mg/kg capsaicin in fractionated daily doses resulted in a facilitation of the hyperthermic reaction. In contrast to other opioids, hypothermia was never observed. Our observations support the concept of multiple opiate-sensitive mechanisms in thermoregulation.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D002211:Capsaicin / Q000494:pharmacology; D004336:Drug Antagonism; D004357:Drug Synergism; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006801:Humans; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013315:Stress, Psychological / Q000503:physiopathology
D009270:Naloxone; D004744:Enkephalin, Methionine; C021717:enkephalin, Met(2)-ProNH2(5)-; D002211:Capsaicin