Inhibition in carotid body chemoreceptors mediated by D-2 dopaminoceptors: antagonism by benzamides.
Inhibition of chemosensory nerve impulses in the cat is evoked by dopamine (DA) applied to carotid body chemoreceptors. Pharmacological characterization of the dopaminoceptors involved in this action was determined through their blockade with benzamides, selective antagonists of D-2 receptors. Both metoclopramide and sulpiride were effective blockers of DA-induced chemosensory inhibition. Furthermore, both drugs induced an immediate increase in the frequency of carotid nerve chemosensory impulses, suggesting the presence of previous tonic inhibition of chemoreceptor discharges by endogenous DA released from glomus cells.
D000818:Animals; D002344:Carotid Body / Q000187:drug effects / Q000502:physiology*; D002415:Cats; D002628:Chemoreceptor Cells / Q000187:drug effects / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D008787:Metoclopramide / Q000494:pharmacology*; D009433:Neural Inhibition / Q000187:drug effects*; D011954:Receptors, Dopamine / Q000502:physiology*; D013469:Sulpiride / Q000494:pharmacology*
D011954:Receptors, Dopamine; D013469:Sulpiride; D008787:Metoclopramide