Electrogenesis of freshly explanted spontaneously active clusters of neonatal rat ventricle cells.
Spontaneously active explanted rat ventricle cells show 4 to 7 h after explantation fast rising TTX sensitive action potentials but 24 h after explantation, electrogenesis is determined by slow rising. Mn sensitive action potentials. Because 4 to 7 h after explantation the electrical properties of the cells resemble more those of the tissue they were derived from than of cells 24 h after explantation, we conclude that the occurrence of slow rising action potentials is not directly related to the method of tissue disintegration but develops gradually after explantation.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D006321:Heart / Q000502:physiology*; D006352:Heart Ventricles / Q000187:drug effects; D008345:Manganese / Q000494:pharmacology; D051381:Rats; D013779:Tetrodotoxin / Q000494:pharmacology; D016276:Ventricular Function
D008345:Manganese; D013779:Tetrodotoxin