In vitro effect of certain compounds on the lysosomal release of polymorphonuclear leukocytes.
From studies on the release of acid phosphatase and B-glucuronidase, it was observed that quercetin, a vitamin P like compound and ascorbic acid stablise while dehydroascorbate, acetoacetate and B-hydroxybutyrate labilise the leukocytic lysosomes in vitro. These effects were compared with chloroquine and progesterone, known stabiliser and destabiliser, respectively. The possible mode of lysosomal labilisation by ketone bodies and dehydroascorbate has been suggested.
D020155:3-Hydroxybutyric Acid; D000090:Acetoacetates / Q000494:pharmacology; D000135:Acid Phosphatase / Q000097:blood; D001205:Ascorbic Acid / Q000031:analogs & derivatives*; D002729:Chloromercuribenzoates / Q000494:pharmacology; D003683:Dehydroascorbic Acid / Q000494:pharmacology*; D005966:Glucuronidase / Q000097:blood; D005978:Glutathione / Q000494:pharmacology; D006801:Humans; D006885:Hydroxybutyrates / Q000494:pharmacology; D066298:In Vitro Techniques; D007657:Ketone Bodies / Q000494:pharmacology*; D008247:Lysosomes / Q000187:drug effects* / Q000201:enzymology; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology; D020245:p-Chloromercuribenzoic Acid
D000090:Acetoacetates; D002729:Chloromercuribenzoates; D006885:Hydroxybutyrates; D007657:Ketone Bodies; C016635:acetoacetic acid; D020245:p-Chloromercuribenzoic Acid; D000135:Acid Phosphatase; D005966:Glucuronidase; D005978:Glutathione; D001205:Ascorbic Acid; D020155:3-Hydroxybutyric Acid; D003683:Dehydroascorbic Acid