title: Domain structures of cell surface glycopeptides encoded by class I and class II beta genes of the major histocompatibility complex.
abstract: Published sequence data of MHC genes, cDNAs and MHC products were analyzed for their sequence homologies. Alignment statistics revealed that class I gene products consist of four mutually homologous domains, and that class II beta gene products is composed of three mutually homologous domains. Not only extracellular domains but also newly discovered C-terminal shorter domains of class I and class II beta gene products were found to have evolved from a one-domain-long beta 2-microglobulin-like protein by repeated exon duplications and splittings.
mesh_terms: D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D005796:Genes; D006023:Glycoproteins / Q000235:genetics*; D006183:H-2 Antigens / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D046911:Macromolecular Substances; D008285:Major Histocompatibility Complex; D051379:Mice; D011487:Protein Conformation
chemical_list: D006023:Glycoproteins; D006183:H-2 Antigens; D006680:HLA Antigens; D046911:Macromolecular Substances