Prediction of multiple-dose blood level curves of drugs with rapid changes in doses and/or dosing intervals.
This paper describes a program which can predict multiple-dose blood level curves of any drug administered orally or intravenously with up to a maximum of three changes in the dosage regimen at any time during the treatment period. This program is applicable to any drug in a given individual provided that the single-dose blood level curve equation (in the form of a two-exponential function) of the first or the last dose of the therapy in this individual is known.
D000284:Administration, Oral; D003201:Computers; D004077:Digoxin / Q000008:administration & dosage / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007275:Injections, Intravenous; D004364:Pharmaceutical Preparations / Q000008:administration & dosage / Q000097:blood*; D011802:Quinidine / Q000008:administration & dosage / Q000097:blood; D012984:Software
D004364:Pharmaceutical Preparations; D004077:Digoxin; D011802:Quinidine