In vivo metabolism of 3,2'-dimethyl-4-aminobiphenyl (DMAB) bearing on its organotropism in the Syrian golden hamster and the F344 rat.
The in vivo metabolism of tritiated DMAB was examined in male Syrian golden hamsters, which are susceptible to both urinary bladder and intestinal carcinogenesis by this agent and in male F344 rats in which intestinal tumors represent the main lesions. Evidence was obtained for the presence of the N-hydroxy-N-glucuronide of DMAB as a major metabolite in hamster urine and bile and in rat bile but not urine. The routes of excretion of this metabolite, which may represent a transport form of the ultimate carcinogen, correlate well with the main tumor sites in the two species. Other metabolites partially identified were the sulfates and glucuronides of C-hydroxylated DMAB and C-hydroxylated-N-acetyl DMAB.
D000611:Aminobiphenyl Compounds; D000814:Aniline Compounds / Q000378:metabolism*; D000818:Animals; D001646:Bile / Q000378:metabolism; D001665:Binding Sites; D002273:Carcinogens / Q000378:metabolism*; D002855:Chromatography, Thin Layer; D006224:Cricetinae; D004159:Diphenylamine / Q000031:analogs & derivatives / Q000378:metabolism*; D005965:Glucuronates / Q000652:urine; D007414:Intestinal Neoplasms / Q000139:chemically induced; D008297:Male; D013058:Mass Spectrometry; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009928:Organ Specificity; D051381:Rats; D011916:Rats, Inbred F344; D013045:Species Specificity; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced
D000611:Aminobiphenyl Compounds; D000814:Aniline Compounds; D002273:Carcinogens; D005965:Glucuronates; C001042:2',3-dimethyl-4-aminobiphenyl; D004159:Diphenylamine