Differences in some erythroid regulatory parameters between two inbred mouse strains.
Normal erythropoiesis in inbred CBA/Tr x CBA/Tr mice is shown to be associated with higher rates of red blood cell production and destruction than in age-matched, but significantly larger, C57Bl6/Tr x C57Bl6/Tr mice. As expected from these observations, serum Ep titers were significantly higher in the CBA/Tr mice than in the C57Bl6/Tr mice. These differences, which appear to result from variations in the operating point for erythropoiesis, can explain the different in vitro erythropoietin sensitivities of hematopoietic tissue from these two mouse strains.
D000818:Animals; D003857:Deoxyuridine / Q000378:metabolism; D004905:Erythrocyte Aging; D004920:Erythropoiesis; D004921:Erythropoietin / Q000494:pharmacology; D005260:Female; D005333:Fetus; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000097:blood*; D008808:Mice, Inbred CBA / Q000097:blood*; D011247:Pregnancy
D004921:Erythropoietin; D003857:Deoxyuridine