Muscarinic cholinergic receptors of the convulsive strain (E1) mouse.
The biochemical characteristics of the muscarinic acetylcholine receptors were studied on the E1 strain mouse brain by the binding assay using [3H]1- quinuclidinyl benzylate. Scatchard analyses showed that the receptor density (Bmax) of the hippocampus significantly decreased by 26.4% and the affinity (Kd) increased by 18.8% in E1(+) compared to dd-Y. It is suggested that this hippocampal subsensitivity found in E1(+) mouse might be strain-specific, because repeated megimide convulsions failed to produce the same down regulation.
D000818:Animals; D001534:Bemegride; D006624:Hippocampus / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D011976:Receptors, Muscarinic / Q000378:metabolism*; D012640:Seizures / Q000139:chemically induced / Q000235:genetics / Q000378:metabolism*; D013045:Species Specificity
D011976:Receptors, Muscarinic; D001534:Bemegride; D011813:Quinuclidinyl Benzilate