Hexamethylenebisacetamide-mediated induction of murine erythroleukemia cells: relationship between expression of beta major and beta minor globin genes, globin mRNA synthesis and commitment to erythroid differentiation.
A switch in beta globin gene expression is operated in murine Friend erythroleukemia cells due to the inducing agent used. The competence of Friend cells to express beta major globin genes is operated within 8 hours exposure to hexamethylenebisacetamide. This early feature of induced differentiation is expressed in the absence of beta globin mRNA synthesis and is not suppressed by the corticosteroid hormone dexamethasone, which by contrast inhibits later stages of induced-mediated commitment to erythroid differentiation such as globin mRNA accumulation and heme synthesis.
D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics*; D002454:Cell Differentiation / Q000187:drug effects; D004268:DNA-Binding Proteins; D003907:Dexamethasone / Q000494:pharmacology; D005796:Genes / Q000187:drug effects*; D005914:Globins / Q000235:genetics*; D006418:Heme / Q000494:pharmacology; D006454:Hemoglobins / Q000235:genetics; D007942:Leukemia, Experimental / Q000503:physiopathology*; D051379:Mice; D012333:RNA, Messenger / Q000235:genetics*; D014158:Transcription, Genetic / Q000187:drug effects*
D000081:Acetamides; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D006454:Hemoglobins; D012333:RNA, Messenger; D006418:Heme; D003907:Dexamethasone; D005914:Globins; C014026:hexamethylene bisacetamide