Effects of papain treatment of lymphocytes on the expression of their membrane surface markers.
Surface marker characteristics of normal and CLL lymphocytes were often considerably modified by treatment with papain. E-SRBC of normal lymphocytes were markedly increased while those of the CLL lymphocytes remained unchanged except in occasional instances. By comparison, EA gamma of normal lymphocytes were unaffected while those of the CLL lymphocytes were markedly increased in most instances. These changes were consistent with reclustering of these receptor sites induced by papain. EAC and E-MRC were destroyed in both groups but SmIg remained unchanged.
D000818:Animals; D001665:Binding Sites; D002417:Cattle; D005312:Fetal Blood / Q000276:immunology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology; D008214:Lymphocytes / Q000187:drug effects*; D009439:Neuraminidase / Q000494:pharmacology; D010206:Papain / Q000494:pharmacology*; D011947:Receptors, Antigen, B-Cell / Q000276:immunology*; D012397:Rosette Formation
D011947:Receptors, Antigen, B-Cell; D009439:Neuraminidase; D010206:Papain