[Participation of temperate phages LP52 and BL20 in the control of bacitracin synthesis in Bacillus licheniformis].
The synthesis of the antibiotic bacitracin in lysogenic and nonlysogenic strains of Bacillus licheniformis 1001 and ATCC10716 has been studied. The antibiotic activity was shown to be about 20% less in lysogens, as compared to nonlysogens. However, the level of bacitracin production was completely restored when temperate bacteriophages BL20 and LP52 were reintroduced into the nonlysogenic strains by virtue of genetic transformation with DNA from lysogenic strains or by transduction with LP52. This may indicate that both phages take part in control of the synthesis of bacitracin. For the time being, the mechanism of regulation is not known. It is likely to be either direct (provided that prophage DNA contains "bacitracin" genes), or indirect.
D001407:Bacillus / Q000235:genetics / Q000378:metabolism*; D001414:Bacitracin / Q000096:biosynthesis*; D001435:Bacteriophages / Q000235:genetics / Q000378:metabolism*; D008242:Lysogeny; D014161:Transduction, Genetic; D014169:Transformation, Bacterial
D001414:Bacitracin
Izuchenie uchastiia umerennykh fagov LP52 i BL20 v kontrole sinteza batsitratsina u Bacillus licheniformis.