Tissue-specificity of reactivity to concanavalin-A of human cells in culture.
Concanavalin-A (Con-A) reactivity was studied to identify the tissue-specificity of cells established from various normal human tissues. Cells were treated with Con-A-labelled human red blood cells (C-RBC). C-RBC was not absorbed on the cells derived from the bone marrow, skin and liver. Lung-derived fibroblast cells showed weak C-RBC adsorption. Kidney-derived cells showed epithelial morphology and easily adsorbed C-RBC. These suggest that a large number of Con-A receptors exists on the membrane surface of kidney cells.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001854:Bone Marrow Cells; D002462:Cell Membrane / Q000502:physiology; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D003208:Concanavalin A / Q000494:pharmacology*; D004912:Erythrocytes / Q000502:physiology*; D005260:Female; D005333:Fetus / Q000166:cytology; D005347:Fibroblasts / Q000187:drug effects; D006382:Hemadsorption / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007223:Infant; D007231:Infant, Newborn; D007668:Kidney / Q000166:cytology; D008099:Liver / Q000166:cytology; D008168:Lung / Q000166:cytology; D008297:Male; D008875:Middle Aged; D009928:Organ Specificity; D011247:Pregnancy; D011952:Receptors, Concanavalin A / Q000187:drug effects; D012867:Skin / Q000166:cytology
D011952:Receptors, Concanavalin A; D003208:Concanavalin A