title: An improved method for the chemical synthesis of steroidal 20-oxo-21-oic acids.
abstract: A procedure is described for the chemical synthesis of steroidal-20-oxo-21-oic acids and -17 alpha(-hydroxy-20-oxo-21-oic acids. Corticosteroid derivatives containing the 20-oxo-21-aldehyde side chain are oxidized with freshly generated silver oxide in dilute aqueous sodium hydroxide.
mesh_terms: D007651:Keto Acids / Q000138:chemical synthesis*; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D010084:Oxidation-Reduction; D013256:Steroids / Q000138:chemical synthesis*
chemical_list: D007651:Keto Acids; D013256:Steroids