Effect of chronic ethanol ingestion on liver and plasma protein synthesis in galactosamine-induced hepatitis in rats.
In rats a single injection (330 mg/kg) of D-galactosamine significantly inhibited in vivo incorporation of 14C-amino acids into fibrinogen, seromucoids and total liver proteins, but not albumin, by one third. Prior chronic exposure to ethanol (5 g/kg/day for 6 weeks) potentiated the inhibition of synthesis of all protein fractions (including albumin) up to about 50%. Propylthiouracil had no beneficial but deleterious effect against this potentiation of hepatotoxicity.
D000437:Alcoholism / Q000378:metabolism*; D000818:Animals; D001798:Blood Proteins / Q000096:biosynthesis*; D056486:Chemical and Drug Induced Liver Injury / Q000378:metabolism*; D005688:Galactosamine; D006801:Humans; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008297:Male; D011441:Propylthiouracil / Q000494:pharmacology; D014176:Protein Biosynthesis; D051381:Rats; D011919:Rats, Inbred Strains
D001798:Blood Proteins; D011441:Propylthiouracil; D005688:Galactosamine