[In vitro study of the neutralizing effect of the most frequently used antacids].
Sixteen antacids were characterized as well as the milk as regards the acid-bounding properties. The study was carried out via the automatic pH-meter titrigraph (Radiometer--Copenhagen). Quantitative data on the acid-bounding capacity were obtained, as well as on the buffer properties and the duration of the interaction between the drugs studied with the titrating solution of hydrochloric acid. The information from that study could well be useful for our pharmaceutical industry, serving as a base for in vivo studies on antacids and in the therapeutic practice for preparing the therapeutic schedules for ulcer disease.
D000818:Animals; D000863:Antacids / Q000494:pharmacology*; D002021:Buffers; D004353:Drug Evaluation, Preclinical; D004347:Drug Interactions; D005782:Gels; D006851:Hydrochloric Acid / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008892:Milk; D012996:Solutions; D013607:Tablets
D000863:Antacids; D002021:Buffers; D005782:Gels; D012996:Solutions; D013607:Tablets; D006851:Hydrochloric Acid
In vitro izsledvane neutralizirashtiia efekt na naĭ-chesto izpolzuvanite antiatsidni lekarstveni sredstva.