[Thrombocyte morphology and function during high-dose immunoglobulin therapy in acute and chronic idiopathic thrombocytopenic purpura. 1].
We examined the effectiveness of a high-dose Immunglobulin therapy in 8 patients with idiopathic thrombocytopenic purpura (ITP) and measured the number, the morphology and the function of Thrombocytes as well as thrombocyte dependent clotting parameters. 0.5 g/kg/B.W. 7s-Immunglobulin (7s-IgG) per treatment led to normal thrombocyte numbers in 7 out of 8 patients. The maximal thrombocyte-rise occurred on the 4th-10th day of treatment. Simultaneously bleeding time, thrombocyte-volume distribution frequency and Ristozetin-ADP and Collagen induced thrombocyte-aggregation normalized-indication as well as cause of the 7s-IgG-therapy are discussed.
D000293:Adolescent; D001760:Bleeding Time; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count; D011696:Purpura, Thrombocytopenic / Q000097:blood / Q000188:drug therapy*
D007074:Immunoglobulin G
Untersuchungen zur Thrombozytenmorphologie und -funktion unter hochdosierter Immunglobulin-Therapie bei akuter und chronischer idiopathisch thromobozytopenischer Purpura (ITP). 1. Mitteilung.