title: Changes in serum and tissue fibronectin during ontogeny.
abstract: It has been proved that both in bovine and rat serum fibronectin concentration increases with age. While in foetal bovine the serum fibronectin concentration was 77 +/- 5 micrograms/ml, in adult cows the concentration of this protein reached 150.0 +/- 5.5 micrograms/ml. In newborn rats, the corresponding fibronectin concentration in the serum was 227 +/- 25 micrograms/ml as compared to 455 +/- 47 micrograms/ml in adult individuals. On the contrary, a drop in fibronectin concentration was found in the bovine glomerular basement membrane: fibronectin represents 3.8 +/- 0.6% of total protein in the newborn, while in animals older than two months this protein was not detectable. Accordingly, in newborn rats fibronectin represents 5.1 +/- 0.6% of total protein in the glomerular basement membrane and drops dramatically to 0.4 +/- 0.1% after one year of life with no detectable changes thereafter. In the alveolar basement membrane the changes are similar as in the glomerular basement membrane. While in newborn rats this protein represents 13.2 +/- 0.5% of total basement membrane protein, it drops to 3.2 +/- 0.3% after two years of life.
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001485:Basement Membrane / Q000032:analysis*; D002417:Cattle; D005353:Fibronectins / Q000032:analysis* / Q000097:blood; D007678:Kidney Glomerulus / Q000032:analysis; D008297:Male; D011650:Pulmonary Alveoli / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005353:Fibronectins