title: [Long-term treatment of arterial hypertension with a new combined preparation obsilazin].
abstract: Thirty-three patients with essential hypertension and two with symptomatic arterial hypertension (Stage I-III) were treated for about two years with the drug obsilazin containing 50 mg propranolol and 50 mg dihydralazin per tablet (the maximum average dose of each drug was 174 mg/day). In 18 patients (51.4%), the arterial pressure returned to normal; in 16 (45.7%) it dropped by more than 10% and one patient showed no response to the treatment. The decrease in systolic and diastolic pressure averaged 20%. The hypotensive effect of obsilazin lasted for several years, attended by no paradoxical reactions on the part of arterial pressure. In individual treatment-refractory cases, the hypotensive effect of obsilazin was strengthened by adding disostate into the treatment modality studied.
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D004078:Dihydralazine / Q000008:administration & dosage*; D004338:Drug Combinations / Q000008:administration & dosage; D006801:Humans; D006830:Hydralazine / Q000031:analogs & derivatives*; D006973:Hypertension / Q000188:drug therapy*; D011433:Propranolol / Q000008:administration & dosage*; D011437:Propylamines / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D004338:Drug Combinations; D011437:Propylamines; C039687:obsilazin; D006830:Hydralazine; D011433:Propranolol; C007442:diisopropylamine; D004078:Dihydralazine
vernacular_title: Dlitel'noe lechenie arterial'noĭ gipertenzii novym kombinirovannym preparatom obsilazinom.