Consequences of decreased brain serotonin in the pyridoxine-deficient young rat.
The concentrations of serotonin in various brain areas were significantly decreased in the pyridoxine-deficient young rat. There was no change in the concentration of dopamine. Both Bmax and Kd of [3H]serotonin binding to membrane preparations from cerebral cortex were increased in deficiency and were restored to normal upon pyridoxine supplementation. There was no change in [3H]spiroperidol binding to corpus striatal membrane preparations in pyridoxine-deficient rats.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D005260:Female; D011247:Pregnancy; D011732:Pyridoxal Phosphate / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism*; D026681:Vitamin B 6 Deficiency / Q000378:metabolism*
D012701:Serotonin; D011732:Pyridoxal Phosphate; D004298:Dopamine