[Immunocorrective action of tuftsin during exposure to ionizing radiation].
The effect of the tetrapeptide tuftcin (Thr-Lys-Pro-Arg) on the humoral immune response in CBA mice exposed to sublethal irradiation in a dose of 450 sGy was studied. The drug was injected intraperitoneally for 5 days before (series I) or after (series II) radiation exposure. It has been shown that taftcin has no protective action but decreases considerably the immune response lowering due to radiation.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects / Q000528:radiation effects; D007108:Immune Tolerance / Q000187:drug effects / Q000528:radiation effects*; D007128:Immunoglobulin Fragments / Q000008:administration & dosage*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011837:Radiation-Protective Agents / Q000008:administration & dosage*; D014405:Tuftsin / Q000008:administration & dosage*
D007128:Immunoglobulin Fragments; D011837:Radiation-Protective Agents; D014405:Tuftsin
Immunokorrigiruiushchee vliianie taftstina pri vozdeĭstvii na organizm ioniziruiushcheĭ radiatsii.