[Experimental ARDS and its prevention].
Our retrospective study on the postoperative ARDS and DIC in surgical patients, during the period of April, 1974 through October, 1980, revealed the presence of DIC in all the 13 patients with ARDS. Although ARDS was not found to have developed in all the patients with DIC, the number of which was 28, we speculated that DIC might have underlain ARDS, on the basis of an observation that the parameters for respiratory functions had changed nearly in parallel with those for the blood coagulation and fibrinolysis. Our animal study in dogs seems to support our concept, which showed a good correlation between the severity of respiratory functions and that of consumption coagulopathies. By giving animals a variety of chemical agents and drugs prophylactically in order to inhibit platelets or blood coagulation or both, we clearly showed that respiratory functions were significantly well preserved when compared with the control group. Thus we would like conclusively remark that DIC may underly and trigger ARDS under certain postoperative conditions, although not all the contributory factors have been clarified at this stage of investigation.
D000818:Animals; D001779:Blood Coagulation Factors / Q000032:analysis; D004195:Disease Models, Animal; D004211:Disseminated Intravascular Coagulation / Q000150:complications*; D004285:Dogs; D006801:Humans; D010976:Platelet Count; D011183:Postoperative Complications; D012128:Respiratory Distress Syndrome / Q000209:etiology / Q000517:prevention & control*
D001779:Blood Coagulation Factors