title: Effect of chronic administration of fenfluramine and quipazine on body weight gain after ovariectomy and on brain serotonin receptor binding.
abstract: Chronic fenfluramine administration prevented excess weight gain following ovariectomy in rats but did not alter weight gain in sham-operated controls. Chronic quipazine treatment had no long-term effect on body weight. In one experiment, fenfluramine treatment for 28 days produced a 13% decrease in [3H]-serotonin binding to hypothalamic membranes and no change in [3H]-spiroperidol binding to striatum. In a second experiment, however, chronic fenfluramine had no effect on [3H]-serotonin binding to diencephalon. These results are discussed in terms of central and peripheral mechanisms of action and tolerance to fenfluramine.
mesh_terms: D000818:Animals; D001066:Appetite / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects*; D001921:Brain / Q000187:drug effects*; D002369:Castration; D005260:Female; D005277:Fenfluramine / Q000494:pharmacology*; D009115:Muridae; D011804:Quinolines / Q000494:pharmacology*; D011814:Quipazine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D012701:Serotonin / Q000378:metabolism; D013134:Spiperone / Q000378:metabolism
chemical_list: D011804:Quinolines; D011985:Receptors, Serotonin; D005277:Fenfluramine; D012701:Serotonin; D011814:Quipazine; D013134:Spiperone