Selenium efficiently depressed toxic side effect of cis-diamminedichloroplatinum.
Effect of selenium on toxic side effects of cis-diamminedichloroplatinum (Cisplatin; CDDP) which is a potent anticancer drug containing platinum was examined. Remarkable protective effects of selenium against lethal and renal toxicity of CDDP were observed when selenite was administered to mice once a day after single injection of lethal dose of CDDP. On the other hand antitumor activity of CDDP was hardly depressed by selenite.
D000818:Animals; D001806:Blood Urea Nitrogen; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D002945:Cisplatin / Q000009:adverse effects* / Q000627:therapeutic use; D007668:Kidney / Q000187:drug effects*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D020887:Selenious Acid; D012643:Selenium / Q000494:pharmacology*
D020887:Selenious Acid; D012643:Selenium; D002945:Cisplatin