High-dose ascorbic acid decreases detoxification of cyanide derived from amygdalin (laetrile): studies in guinea pigs.
Cysteine, a sulphur-containing amino acid, is required to metabolize ascorbic acid (as ascorbate sulphate) and detoxify cyanide (to thiocyanate). In guinea pigs, conjoint use of laetrile (a cyanogenic glycoside) and ascorbic acid (in large doses) decreases the detoxification of cyanide derived from laetrile through diminishing the availability of cysteine, but not impairing hepatic rhodanese activity, which is involved in the detoxification of cyanide to thiocyanate. These results agree with the symptoms of a sublethal dose of KCN toxicity manifested by the animals. The studies, therefore, indicate that individuals taking megadoses of ascorbic acid concurrently with laetrile may be subject to self-poisoning.
D000678:Amygdalin / Q000378:metabolism*; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D003486:Cyanides / Q000378:metabolism*; D006168:Guinea Pigs; D008658:Inactivation, Metabolic / Q000187:drug effects; D011190:Potassium Cyanide / Q000378:metabolism; D013861:Thiocyanates / Q000378:metabolism
D003486:Cyanides; D013861:Thiocyanates; D000678:Amygdalin; D011190:Potassium Cyanide; D001205:Ascorbic Acid