Effects of amsacrine (m-AMSA), a new aminoacridine antitumor drug, on the rabbit heart.
There is emerging clinical evidence that amsacrine (m-AMSA) administration may be associated with cardiotoxic effects such as severe, even fatal, ventricular arrhythmias and impairment of the inotropic performance of the heart. Information on the cardiac effects of m-AMSA in animals is scanty. Studies on mice, dogs, and monkeys have not evidenced the cardiotoxicity of the compound. The data presented in this paper show that m-AMSA causes acute ECG alterations in normal rabbits and a dose-related negative inotropic effect on the isolated rabbit heart, suggesting that this species may be a useful model for the study of the cardiac actions of this antiblastic.
D000609:Aminoacridines / Q000633:toxicity*; D000677:Amsacrine; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects*; D006334:Heart Function Tests; D006352:Heart Ventricles / Q000187:drug effects; D008954:Models, Biological; D009200:Myocardial Contraction / Q000187:drug effects; D011817:Rabbits
D000609:Aminoacridines; D000970:Antineoplastic Agents; D000677:Amsacrine