Study of subacute toxicity of CDP-choline after 30 days of oral administration to rats.
Two groups of rats were administered by oral route doses of 100 and 150 mg/kg, respectively, of cytidine diphosphate choline (CDP-choline citicoline, Somazina), daily during 30 days. At the end of the test, animals were killed and necropsied, evaluating the urinary, haematological, serum biochemistry and histopathological parameters. The study did not reveal any signs of toxicity.
D000284:Administration, Oral; D000375:Aging; D000818:Animals; D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000633:toxicity*; D004032:Diet; D004435:Eating / Q000187:drug effects; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D003566:Cytidine Diphosphate Choline; D002794:Choline