[Idiopathic thrombocytopenic purpura: diagnosis and therapy in 46 patients].
The hematological and immunological data of 46 patients with idiopathic thrombozytopenic purpura (ITP) and their response to treatment are reported. The findings are as follows: (1) Antiplatelet antibodies (serum assays) cannot be recommended as a useful diagnostic approach in ITP. (2) Circulating immune complexes are demonstrable in 77% of our patients. (3) The bone marrow contains increased numbers of eosinophils and erythrocytes in about the half of the patients. (4) A "remission" is obtained in 50% of patients with corticosteroids and in 60-80% with splenectomy. Among the immunosuppressants, cyclophosphamide appears to be the most useful. (5) Fatal hemorrhages are very rarely seen in adults with ITP.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis; D001792:Blood Platelets / Q000276:immunology; D001853:Bone Marrow / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007518:Isoantibodies / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011241:Prednisone / Q000008:administration & dosage; D011696:Purpura, Thrombocytopenic / Q000097:blood* / Q000188:drug therapy / Q000276:immunology; D013156:Splenectomy
D000936:Antigen-Antibody Complex; D006454:Hemoglobins; D007518:Isoantibodies; D003520:Cyclophosphamide; D011241:Prednisone
Idiopathische thrombozytopenische Purpura: Diagnostik und Therapie bei 46 Patienten.