Cholinergic receptor control mechanisms for L-dopa, apomorphine, and clonidine-induced growth hormone secretion in man.
The effect of pirenzepine, an anticholinergic agent, on GH release induced by L-dopa (500 mg po), apomorphine (0.75 mg sc), and clonidine (0.150 mg iv) administration was studied in a group of normal men. Pirenzepine, a cholinergic muscarinic antagonist, completely blocked the GH rise induced by dopamine- and adreno-receptor stimulation. In contrast, the PRL-inhibiting action of L-dopa was not modified by the cholinergic antagonist. The data suggest that acetylcholine and its receptors are important regulators of the neurosecretory mechanisms that control GH secretion in man.
D000328:Adult; D001058:Apomorphine; D001570:Benzodiazepinones; D003000:Clonidine; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D007980:Levodopa; D008297:Male; D010276:Parasympatholytics; D010890:Pirenzepine; D011388:Prolactin / Q000378:metabolism; D011950:Receptors, Cholinergic / Q000502:physiology*
D001570:Benzodiazepinones; D010276:Parasympatholytics; D011950:Receptors, Cholinergic; D010890:Pirenzepine; D007980:Levodopa; D011388:Prolactin; D013006:Growth Hormone; D003000:Clonidine; D001058:Apomorphine