title: Autoimmune thrombocytopenic purpura. Comparison of three different methods for the detection of platelet antibodies.
abstract: An evaluation of three techniques for detection of antiplatelet antibodies in ATP is made. The platelet factor 3 availability after immunoinjury and the immunohystochemical technique using immunoperoxidase were more sensitive than 14C-5HT release from platelets for this purpose. The percentage of positive cases was similar in acute and chronic ATP patients while it significantly fell in cases in remission. A high proportion of patients in clinical remission had normal platelet aggregation, despite the persistence of antiplatelet antibodies.
mesh_terms: D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000276:immunology*; D001792:Blood Platelets / Q000276:immunology*; D006801:Humans; D010974:Platelet Aggregation; D011696:Purpura, Thrombocytopenic / Q000276:immunology*
chemical_list: D001323:Autoantibodies