Effect of 1 alpha, 24 R,25-trihydroxycholecalciferol on isolated parathyroid cells secretion.
In this work we have studied the action of the trihydroxylated vitamin D metabolite (1 alpha, 24 R,25(OH)3D3) on parathyrin secretion by isolated parathyroid cells. In contrast with the results obtained with mono and dihydroxylated vitamin D, 1 alpha, 24 R,25(OH)3D3 increased the secretion of parathyrin. The effective concentration of this metabolite was 1.54 X 10(-9)M for cells rat and 1.54 X 10(-10)M for human cells.
D000818:Animals; D006801:Humans; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D010280:Parathyroid Glands / Q000187:drug effects* / Q000378:metabolism; D010281:Parathyroid Hormone / Q000378:metabolism; D051381:Rats
D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone; C013721:1,24,25-trihydroxyvitamin D3