Early changes in blood flow of the mouse skin after irradiation as measured by the 133Xe clearance method.
The early effects of radiation on the local blood flow in the skin of mice were evaluated by measuring the local clearance rate of 133Xe after its subcutaneous injection; this was done at four to five weeks after irradiation during the animals' normal resting conditions. The fractionation schedules employed were single fractions, two fractions in 15 days and four fractions in 15 days. The dose effect curves with these schedules showed a two-component pattern. There was a uniform reduction in flood flow after 10 to 30 Gy, and a steady increase in flood flow after doses more than 40 Gy. The blood flow after higher-fractionated doses was always lower than after less-fractionated doses. It was considered that radiation doses causing higher severity of acute skin reactions might have predominated a degree of acute vasodilatation over fibrotic changes, thus resulting in increased blood flow. A steady increase in early blood flow was observed with increasing severity of acute skin reactions, but the early blood flow was not a good indicator for predicting late skin reactions, except for a severe leg deformity which was accompanied with a significant increase in early blood flow.
D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012039:Regional Blood Flow / Q000528:radiation effects; D012867:Skin / Q000098:blood supply* / Q000528:radiation effects; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes