title: Penetration of trimethoprim--sulfadiazine into middle ear fluid in secretory otitis media.
abstract: Thirty-nine middle ear fluid samples from 23 patients with chronic secretory otitis media were studied. The patients received 3 doses of 3 mg of trimethoprim and 5 mg of sulfadiazine per kg body weight before tympanostomy, the last dose being given 80-270 min (mean 142 min) prior to operation. Mean trimethoprim concentrations were 1.62 micrograms/ml (range 0.8-3.5) and mean sulfadiazine concentrations 10.54 micrograms/ml (range 0-25.0). For most patients the levels exceeded the usual MIC-values for the two commonest pathogens; pneumococci and Haemophilus influenzae. Otitis media caused by beta-lactamase producing Haemophilus is an important indication for trimethoprim-sulfonamide therapy.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004432:Ear, Middle / Q000378:metabolism* / Q000382:microbiology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D010033:Otitis Media / Q000188:drug therapy*; D010034:Otitis Media with Effusion / Q000188:drug therapy* / Q000382:microbiology; D013411:Sulfadiazine / Q000378:metabolism* / Q000627:therapeutic use; D014295:Trimethoprim / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D013411:Sulfadiazine; D014295:Trimethoprim