title: The effect of lithium, imipramine and chlorpromazine on the membrane bound enzyme phosphatidylethanolamine methyltransferase.
abstract: The activity of phosphatidylethanolamine methyltransferase (PMT) in disrupted human erythrocytes and ghost cells was inhibited by lithium (Li+), imipramine and chlorpromazine. There was no inhibitory effect of the drugs in concentrations similar to the average therapeutic blood levels. Li+ exerted an inhibition on PMT activity in hemolysates at concentrations 8 times the average therapeutic level whereas chlorpromazine and imipramine showed an inhibitory effect on PMT in hemolysates at 10(3) fold their respective therapeutic serum level.
mesh_terms: D002746:Chlorpromazine / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000201:enzymology; D006801:Humans; D007099:Imipramine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008094:Lithium / Q000494:pharmacology*; D008780:Methyltransferases / Q000037:antagonists & inhibitors* / Q000097:blood; D050918:Phosphatidylethanolamine N-Methyltransferase
chemical_list: D008094:Lithium; D008780:Methyltransferases; D050918:Phosphatidylethanolamine N-Methyltransferase; D007099:Imipramine; D002746:Chlorpromazine