title: The effect of tamoxifen on plasma growth hormone and prolactin in postmenopausal women with advanced breast cancer.
abstract: The effect of tamoxifen on serum levels of basal prolactin and basal and stimulated growth hormone was assessed in 10 women with advanced breast cancer prior to and after 1 and 8 weeks of treatment. Tamoxifen had no effect on basal levels of either hormone or on insulin-stimulated growth hormone. Two of 4 patients undergoing arginine provocation testing had a partial response to tamoxifen and both exhibited marked diminution of growth hormone stimulation which was not seen in the non-responders.
mesh_terms: D000368:Aged; D001120:Arginine / Q000494:pharmacology; D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D008593:Menopause; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*; D013629:Tamoxifen / Q000378:metabolism* / Q000627:therapeutic use
chemical_list: D013629:Tamoxifen; D011388:Prolactin; D013006:Growth Hormone; D001120:Arginine