The influence of 1,25-dihydroxycholecalciferol on the mineral content of foetal guinea pigs.
The influence of 1,25-dihydroxycholecalciferol (0.05 microgram/kg bw/day, given I.M. for 10 days) on calcium transfer from dam to foetus and on foetal calcium and phosphate content was observed in 3 groups of 10 guinea pigs, one group on each of days 40, 50 and 66 of gestation. At 40 and 50 days of gestation, 1,25-dihydroxycholecalciferol increased the calcium and phosphate content of the foetus. 45Ca transfer from the dam to placenta (measured during a 30-90 min period) was higher in treated than in control animals.
D000818:Animals; D002117:Calcitriol / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D006168:Guinea Pigs; D008274:Magnesium / Q000378:metabolism; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D010710:Phosphates / Q000378:metabolism*; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy
D010710:Phosphates; D002117:Calcitriol; D008274:Magnesium; D002118:Calcium