[Attempt at determining fetal sex by the simultaneous study of the HY antigen and testosterone in the amniotic fluid].
Attempts have been made to determine fetal sex early by a simultaneous study of H-Y antigen and testosterone in amniotic fluid. H-Y (male) antigen was serologically detected in the amniotic cells from both sexes, but the results obtained from 473 amniotic fluids showed no significant sex differences either in fresh cells or after culture. Testosterone assays done from 263 samples of liquor confirm that the results obtained in cases of male fetuses were significantly higher than in females. 55% of all males and 47% of females could thus be detected to a level of 100% certainty. The probability of having a girl decreases as an inverse function of testosterone levels and comes out at 85% for testosterone less than 200 pg/ml. On the other hand the probability of a male fetus is 95% when the values are above 240 pg/ml. The determination of the testosterone/DHA ratio in order to try to eliminate the influence of the variations in volume has not improved the accuracy of this diagnosis.
D000328:Adult; D000653:Amniotic Fluid / Q000032:analysis* / Q000276:immunology; D005260:Female; D005333:Fetus / Q000276:immunology; D006182:H-Y Antigen / Q000032:analysis*; D006801:Humans; D008297:Male; D008423:Maternal Age; D011247:Pregnancy; D018566:Pregnancy, High-Risk; D011863:Radioimmunoassay; D012732:Sex Determination Analysis; D013739:Testosterone / Q000032:analysis*
D006182:H-Y Antigen; D013739:Testosterone
Essai de détermination du sexe foetal par l'étude simultanée de l'antigène H-Y et de la testostérone dans le liquide amniotique.