Effect of calcium and phosphorus on the gastrointestinal absorption of 203Pb in man.
Calcium and phosphorus were mainly responsible for reducing the gastrointestinal absorption of lead in human subjects. The effect of calcium was greater than phosphorus, and their combined effect was more than additive. Increasing weights of calcium and phosphorus progressively reduced lead absorption. The relationship between absorption and increasing weights could be described by two negative exponentials. These effects could be explained if lead competed with calcium and phosphorus for common transport mechanisms in the gut. Milk was also found to reduce lead absorption. Adding milk to the diet of people with low dietary calcium intake could reduce the possibility of increased absorption of ingested lead.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002136:Calcium, Dietary / Q000494:pharmacology; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007854:Lead / Q000378:metabolism*; D008892:Milk; D010758:Phosphorus / Q000494:pharmacology*; D011868:Radioisotopes
D002136:Calcium, Dietary; D011868:Radioisotopes; D010758:Phosphorus; D007854:Lead; D002118:Calcium