Pharmacokinetic studies on diponium bromide.
The body elimination kinetics and the metabolic pathway of intravenously administered diponium bromide ((2-[alpha,alpha-dicyclopentylacetoxy)- ethyl] triethylammonium bromide) were studied. The rapid alpha- distribution phase had a t 1/2 of 4 to 11 minutes. The elimination rate varied between 2.3 and 7.7 hours. The distribution volume was 29.64 +/- 15.03 l, the total body clearance was 72.99 +/- 28.52 ml/min, and the renal clearance showed a mean value of 45.03 +/- 12.51 ml/minute. Thin layer chromatography of extracts derived from urine and faeces showed unchanged DB and a metabolite in urine; in the faeces of some volunteers three metabolites were detected, which were characterized by their Rf-values. DB does not bind to erythrocytes but to plasma proteins.
D000328:Adult; D002855:Chromatography, Thin Layer; D004912:Erythrocytes / Q000378:metabolism; D005243:Feces / Q000032:analysis; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D011485:Protein Binding; D000644:Quaternary Ammonium Compounds / Q000378:metabolism*
D000644:Quaternary Ammonium Compounds; C010366:diponium