title: Synthesis, physical properties and microbiological activities of more water soluble silver sulfadiazine derivatives.
abstract: In this study the preparation of five hydrophilic derivatives of sulfadiazine is reported. The common structural element in the compounds is the 2-sulfonamidopyrimidine moiety. Three of these compounds are suitable for the preparation of a photostable I: I silver compound. These silver compounds are five to ten times more water soluble than silver sulfadiazine. The IR, 1H- and 13C-NMR data point to a similar co-ordination of silver in these compounds as with silver sulfadiazine. The microbiological activity of these silver compounds against St. aureus is slightly lower.
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D008826:Microbial Sensitivity Tests; D012837:Silver Sulfadiazine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D012995:Solubility; D013411:Sulfadiazine / Q000031:analogs & derivatives*
chemical_list: D013411:Sulfadiazine; D012837:Silver Sulfadiazine