title: The control of parasitic gastroenteritis of grazing cattle in Normandy, France using the morantel sustained release bolus.
abstract: The efficacy of the morantel sustained release bolus in controlling parasitic gastroenteritis in 153 first-season grazing cattle was assessed in three separate field trials conducted in Normandy, France. In each trial, comparisons were made on weight gain performance and parasitology data (faecal worm egg counts, herbage larval counts and- in two of the trials- worm counts from principal animals sacrificed at the end of the grazing season) when bolus treatment was given either at spring turnout or in mid-season in order to determine the optimum time for bolus administration. Cattle were allocated into three groups, each group maintained on a separate but equivalent paddock constructed from the division of a larger pasture. A morantel sustained release bolus was administered to one group of animals at the time of turnout and to a second group of animals in midsummer. The third group of animals in each trial remained nontreated. The effect of the treatment on the contamination of pasture, and parasite levels and weight gain of the principal trial animals was assessed. Similar results were observed in all three trials. Faecal worm egg counts were reduced during the first part of the grazing season in animals receiving the bolus at turnout compared with mid-season treated animals where egg counts followed a pattern similar to the controls until bolus treatment at which time counts abruptly dropped to a low level. Likewise, levels of infective larvae on pastures grazed by control and mid-season treated animals followed similar patterns, increasing to a high level in late summer, while larval levels on pastures grazed by early-season treated animals remained at low levels throughout most of the season. Serum pepsinogen levels, worm counts and weight gain reflected the results from faecal worm egg and herbage larval counts indicating that early-season treatment with the bolus provided the most efficient treatment time for controlling parasitic gastroenteritis throughout the grazing season. The overall mean weight gain advantage of the early-season bolus-treated animals over the controls was 37.2 kg (P less than 0.01) while the advantage of the mid-season treated animals over controls was 13.7 kg.
mesh_terms: D000818:Animals; D001835:Body Weight; D002417:Cattle / Q000502:physiology; D002418:Cattle Diseases / Q000517:prevention & control*; D003692:Delayed-Action Preparations; D004341:Drug Evaluation / Q000662:veterinary; D005602:France; D007411:Intestinal Diseases, Parasitic / Q000662:veterinary*; D008297:Male; D009015:Morantel / Q000008:administration & dosage* / Q000627:therapeutic use; D009349:Nematode Infections / Q000517:prevention & control / Q000662:veterinary*; D010270:Parasite Egg Count / Q000662:veterinary; D010435:Pepsinogens / Q000097:blood; D010944:Plants / Q000469:parasitology; D011743:Pyrimidines / Q000008:administration & dosage*; D012621:Seasons
chemical_list: D003692:Delayed-Action Preparations; D010435:Pepsinogens; D011743:Pyrimidines; D009015:Morantel