Evidence of hyposplenism in the presence of splenomegaly.
Evidence of hyposplenism (Howell-Jolly bodies, Pappenheimer bodies and nucleated red cells in the blood) was found in a patient with splenomegaly and Hb C disease. Splenic haemangiosarcoma was found at operation. Evidence of hyposplenism in the presence of a normal size or enlarged spleen should alert the physician to the possibility of a complicating factor.
D004908:Erythrocyte Inclusions; D006394:Hemangiosarcoma / Q000209:etiology; D006445:Hemoglobin C Disease / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D013158:Splenic Diseases / Q000209:etiology*; D013160:Splenic Neoplasms / Q000209:etiology; D013163:Splenomegaly / Q000150:complications*