[Features of the effects of apomorphine on rats of different sexes preferring ethyl alcohol].
The influence of apomorphine (1 mg/kg/day subcutaneously) on the behavior and some pharmacokinetic parameters of both male and female rats preferring ethanol to water was studied experimentally. Upon withdrawal of ethanol, apomorphine decreased the time of transmission to water consumption in the rats of both sexes and prevented a decline in the endogenous ethanol levels, the latter effect being especially pronounced in the female rats. Investigations on the "Animex" actograph showed an intensified response to apomorphine in rats preferring ethanol, with female rats displaying a greater change in the response. Under conditions of a renewed access to ethanol, apomorphine increased the time of the restoration of the previous preference for ethanol to water (with a stronger effect seen in females) and lowered the rate of ethanol elimination from the blood (in the female rats exclusively). The effacement of the sex differences in ethanol addicted rats, and a greater damaging impact of ethanol on female rats are emphasized.
D000437:Alcoholism / Q000188:drug therapy*; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology / Q000627:therapeutic use*; D000431:Ethanol / Q000097:blood*; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D012737:Sex Factors; D013239:Stereotyped Behavior / Q000187:drug effects
D000431:Ethanol; D001058:Apomorphine
Osobennosti deĭstviia apomorfina na krys raznogo pola, predpochitaiushchikh étilovyĭ spirt.