Effect of oral administration of fructose on purine nucleotide metabolism in rats.
Oral administration of fructose (4 g/kg body wt) accelerated the production of uric acid and allantoin in rat liver. Changes in the concentrations of various metabolites in the liver after the administration of fructose suggested that this was due to the acceleration of AMP degradation induced by the rapid fall in adenylate energy charge resulted from rapid phosphorylation of fructose with ATP.
D000227:Adenine Nucleotides / Q000378:metabolism; D000284:Administration, Oral; D000481:Allantoin / Q000378:metabolism; D000818:Animals; D005632:Fructose / Q000008:administration & dosage*; D005636:Fructosephosphates / Q000378:metabolism; D005947:Glucose / Q000008:administration & dosage; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011685:Purine Nucleotides / Q000378:metabolism*; D051381:Rats; D014527:Uric Acid / Q000378:metabolism
D000227:Adenine Nucleotides; D005636:Fructosephosphates; D011685:Purine Nucleotides; D014527:Uric Acid; D005632:Fructose; D000481:Allantoin; D005947:Glucose