The cerebral ischemic cascade.
The author reviews the major biochemical events that follow in the wake of a significant brain ischemic insult. Evidence is presented that establishes lactic acidosis as a significant accelerant of the ischemic cascade and that proposes that uncontrolled entry of calcium into the vulnerable neuron triggers cell death.
D000818:Animals; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D002118:Calcium / Q000378:metabolism; D002470:Cell Survival; D002560:Cerebrovascular Circulation; D004734:Energy Metabolism; D005609:Free Radicals; D002546:Ischemic Attack, Transient / Q000378:metabolism* / Q000503:physiopathology; D007773:Lactates / Q000378:metabolism; D009115:Muridae; D012377:Rodentia
D005609:Free Radicals; D007773:Lactates; D002118:Calcium