[Effect of cytoskeleton-disrupting on the redistribution of the surface receptors of cultured cells].
The capacity of cap-formation in cultured cells was shown to increase from 2 to 20 fold upon treating them with ligands in the presence of a conditioned medium. This permitted us to compare the influence of cytoskeleton-disrupting agents on the process of cap-formation in cultured cells of different origin. Cytochalasin was shown to inhibit cap-formation, induced with concanavalin A or anti-H2-serum, both in cells of lymphoid and fibroblastic origin. In contrast, vinblastin did not inhibit cap-formation in cells of lymphoid origin, but caused inhibition in cells of fibroblastic origin twice as strong as did cytochalasin B.
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D003078:Colchicine / Q000494:pharmacology; D003208:Concanavalin A / Q000494:pharmacology; D003572:Cytochalasins / Q000494:pharmacology; D003599:Cytoskeleton / Q000187:drug effects*; D003703:Demecolcine / Q000494:pharmacology; D005347:Fibroblasts / Q000187:drug effects* / Q000276:immunology; D007106:Immune Sera / Q000494:pharmacology; D007152:Immunologic Capping / Q000187:drug effects*; D008024:Ligands; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D014747:Vinblastine / Q000494:pharmacology
D003572:Cytochalasins; D007106:Immune Sera; D008024:Ligands; D003208:Concanavalin A; D014747:Vinblastine; D003078:Colchicine; D003703:Demecolcine
Vliianie agentov, razrushaiushchikh tsitoskelet, na pereraspredelenie poverkhnostnykh retseptorov kul'tiviruemykh kletok.