Effect of exercise and guanethidine on plasma cholesterol and aortic atherosclerosis of atherogenic-fed cockerels.
The effects of exercise (EX) and guanethidine (G) or its combination on plasma cholesterol and incidence and severity of aortic atherosclerosis of atherogenic-fed (AD) cockerels were studied. Eighty-five 16-week-old Hyline cockerels were subdivided as follows: I. Plain mash (PM); II. PM + EX; III. PM + G; IV. PM + EX + G; V. AD only; VI. AD + EX; VII. AD + G; and VIII. AD + EX + G. Birds ran approximately 500 yards for 20 minutes twice daily for twelve consecutive weeks. G (2.5 mg) was administered per os daily. The atherogenic diet consisted of 2% cholesterol + 5% cottonseed oil added to mash. At the end of 12 weeks the following results were obtained: 1) EX or G or its combination had no effect on plasma cholesterol of birds on PM. All AD-fed groups showed marked hypercholesterolemia as compared to their initial values. The AD + EX group had significantly lower plasma cholesterol level when compared to AD controls or AD + G group; 2) no gross aortic atherosclerosis was observed in cockerels on PM. The group on AD only had the most severe gross aortic atherosclerosis while the AD birds treated with G or EX + G had slightly lower aortic atheromatosis. This was in contrast to AD + EX group which showed a significant decrease in aortic atherogenesis. These results indicate that EX reduces plasma cholesterol and aortic atherosclerosis of AD birds while these effects of EX were negated by G.
D000818:Animals; D001018:Aortic Diseases / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D001161:Arteriosclerosis / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D001835:Body Weight; D002395:Catecholamines / Q000502:physiology; D002645:Chickens / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood*; D004036:Diet, Atherogenic; D006145:Guanethidine / Q000494:pharmacology*; D008297:Male; D005082:Physical Exertion
D002395:Catecholamines; D002784:Cholesterol; D006145:Guanethidine