Study of the effects of oral administration of CDP-choline on EEG changes and lethality induced by epidural compression in the anaesthetised cat.
The effects of repeated oral administration of cytidine diphosphate choline (CDP-choline, citicoline, Somazina) and vehicle on the EEG changes induced by epidural brain compression have been studied in the anaesthetised cat. The effects on arterial pressure and heart rate were also monitored. CDP-Choline-treated cats exhibited a statistically significant increase in resistance to the effects of mechanical compression of the brain when compared with the vehicle-treated group. In addition the onset of abnormal EEG waveforms occurred at greater levels of brain compression in drug-treated cats. CDP-Choline also imparted protection against the cardiovascular and respiratory effects of brain compression; animals were apparently less susceptible to cardiac and respiratory failure under the influence of the test compound. A statistically significant protection against the lethal effects of epidural compression was also noted in CDP-choline treated cats. It may be concluded that repeated oral treatment with CDP-Choline provides an apparent protection against the effects of acute mechanical compression of the brain.
D000758:Anesthesia; D000818:Animals; D001921:Brain / Q000187:drug effects*; D002415:Cats; D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000494:pharmacology*; D004569:Electroencephalography; D004824:Epidural Space / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects; D008297:Male; D011312:Pressure; D012119:Respiration / Q000187:drug effects
D003566:Cytidine Diphosphate Choline; D002794:Choline