Intrinsic myelin proteins are normally synthesized in vitro in the myelin-deficient (mld) mutant mouse.
The synthesis of myelin basic protein is severely reduced in the central and peripheral nervous system of myelin-deficient (mld) mutant mice. Using an in vitro system and immunoprecipitation, we found a normal rate of synthesis in mld mice for two intrinsic myelin proteins: proteolipid protein in central nervous system myelin and P0 in peripheral nervous system myelin. These results indicate that protein synthesis on membrane-bound ribosomes is not affected by the mutation.
D000818:Animals; D006023:Glycoproteins / Q000096:biosynthesis; D051379:Mice; D008818:Mice, Neurologic Mutants; D009185:Myelin Proteins / Q000096:biosynthesis*; D011510:Proteolipids / Q000096:biosynthesis
D006023:Glycoproteins; D009185:Myelin Proteins; D011510:Proteolipids