Synthesis and biological activity of some cardiotonic compounds related to digitoxigenin.
3 beta-Amino compounds with 17 beta-(3-furyl) and (4-pyridazinyl) ring systems were prepared from digitoxigenin 1b and found to have similar cardiotonic properties to the analogous 3 beta-hydroxy compounds when tested in the isolated guinea-pig atrial preparation. Derivatives with 3 alpha-acetoxy functions were found to have higher than expected activities. Particularly potent was the pyridazine N1-oxide 19. All isocardenolides and the unsaturated anhydride 18 were devoid of activity.
D000818:Animals; D002316:Cardiotonic Agents / Q000138:chemical synthesis*; D004073:Digitoxigenin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects; D013329:Structure-Activity Relationship
D002316:Cardiotonic Agents; D004073:Digitoxigenin