Renal and extrarenal production of erythropoietin following exchange transfusion with plasma or a perfluorocarbon-polyol.
The extrarenal production of erythropoietin (Ep) was measured in young adolescent rats following exchange-transfusion with normal rat plasma or the whole blood replacement fluid, Fluosol-43. In the plasma-transfused anephric groups, the peak extrarenal Ep response to the severe degree of anemic hypoxia represented 23% of that evoked in renal-intact groups. In contrast, the peak extrarenal production of Ep in Fluosol-transfused renoprival groups was almost equal to those serum Ep levels produced in renal-intact groups. Histological studies revealed significant fluorocarbon uptake by hepatic macrophages that coincided with the time of peak production of Ep. Thus, while intense levels of hypoxia are required to stimulate the extrarenal production of Ep, these data suggest that as Fluosol-43 is taken up by the hepatic macrophages, Ep production by these cells is stimulated.
D000818:Animals; D004921:Erythropoietin / Q000031:analogs & derivatives / Q000096:biosynthesis* / Q000097:blood; D005078:Exchange Transfusion, Whole Blood; D005466:Fluorocarbons / Q000008:administration & dosage / Q000627:therapeutic use; D007668:Kidney / Q000378:metabolism* / Q000503:physiopathology; D008099:Liver / Q000166:cytology / Q000378:metabolism* / Q000502:physiology; D008264:Macrophages / Q000502:physiology; D008297:Male; D051379:Mice; D009392:Nephrectomy; D010951:Plasma Exchange; D051381:Rats
D005466:Fluorocarbons; D004921:Erythropoietin; C100266:erythrogenin