The cholinergic system in rat striatum during morphine tolerance and dependence.
Male Sprague-Dawley rats were used in the present study to assess the effects of chronic treatment of morphine on the striatal cholinergic system. The results demonstrate that neither short nor long-term morphine treatment had an effect on choline acetyltransferase (ChAT) activity or 3H-quinuclidinylbenzilate (3HQNB) binding in discrete striatal regions of the rat brain.
D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000503:physiopathology*; D004361:Drug Tolerance; D006801:Humans; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009021:Morphine Dependence / Q000503:physiopathology*; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011976:Receptors, Muscarinic / Q000187:drug effects
D011976:Receptors, Muscarinic; D011813:Quinuclidinyl Benzilate; D009020:Morphine; D002795:Choline O-Acetyltransferase; D000109:Acetylcholine