title: [Phosphatidylcholine in the treatment of degenerative spinocerebellar ataxic syndromes. Long-term study of 6 patients].
abstract: Six patients: three affected by different forms of inherited spinocerebellar ataxia and the others by acquired sporadic forms, were treated for six months with pure phosphatidylcholine, given orally (3,6 g daily). The open study has shown a significant improvement of spinocerebellar symptomatology after three and six months, in 5 patients. No improvement of the pyramidal symptoms was observed. These results, according to those obtained with lecitin, physostigmine and others choline precursors, suggest a possible pathogenesis with treatment.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002524:Cerebellar Ataxia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D013118:Spinal Cord Diseases / Q000188:drug therapy*; D013577:Syndrome
chemical_list: D010713:Phosphatidylcholines
vernacular_title: La fosfatidilcolina nel trattamento delle sindromi atassiche spinocerebellari degenerative. Studio a lungo termine su sei soggetti.