Evidence that 5-hydroxytryptamine in the forebrain is involved in naloxone-precipitated jumping in morphine-dependent rats.
A withdrawal syndrome was precipitated by naloxone in morphine-dependent rats injected with 5,7-dihydroxytryptamine (5,7-DHT) in the ventromedial tegmentum (VMT) at the level of the nucleus interpeduncularis. 5,7-DHT, which markedly depleted 5-hydroxytryptamine (5-HT) in the forebrain but not in the brainstem, significantly reduced jumping in abstinent rats with no significant effect on other withdrawal signs. The effect of morphine 10 mg kg-1 on responses on the hot plate was unchanged in 5,7-DHT-treated rats. The findings suggest that 5-HT in the forebrain is selectively involved in the jumping of morphine-abstinent rats.
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001921:Brain / Q000502:physiology*; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D009020:Morphine / Q000494:pharmacology; D009021:Morphine Dependence / Q000503:physiopathology*; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D012701:Serotonin / Q000502:physiology*; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*
D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D009270:Naloxone; D009020:Morphine