Erythrocyte membrane stabilization by decamethonium and succinylcholine.
The effects of decamethonium and succinylcholine on hypotonic haemolysis of erythrocytes were studied. These drugs at concentrations of 5 X 10(-8) M to 10(-4) M caused a dose-dependent inhibition of haemolysis of erythrocytes in 0.45% NaCl but lysis occurred when the drug concentrations were increased to 10(-3) M. These results indicate that decamethonium and succinylcholine may have a membrane stabilization-lysis effect on erythrocytes.
D003650:Decamethonium Compounds / Q000009:adverse effects / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D013390:Succinylcholine / Q000009:adverse effects / Q000494:pharmacology*
D003650:Decamethonium Compounds; D013390:Succinylcholine