title: [Pediatric aspects of success and failure of anti-D-prophylaxis].
abstract: During the last 10 years 485 exchange transfusions have been performed in the Children's Hospital of the City of Vienna--Glanzing, about 25% for rhesus immunization. While the frequency of exchange transfusions due to hyperbilirubinaemia and ABO incompatibility could be reduced by 90% by phototherapy and phenobarbital prophylaxis, only 55% reduction was observed in connection with rhesus immunization. Anti-D prophylaxis after the 1. pregnancy had only been carried out in 5 mothers (seen as secunda or multi para). In the 221 cases where exchange transfusion became necessary, 196 mothers of these children never had anti-D prophylaxis. This corresponds to 98%. There were 126 women with multiple pregnancies without abortion and 70 mothers, where anti-D prophylaxis had not been carried out after abortion. Consequently anti-D prophylaxis, especially including abortions both natural and induced, could substantially reduce the number of rhesus-sensitized newborns, requiring exchange transfusion.
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000328:Adult; D001663:Bilirubin / Q000097:blood; D004899:Erythroblastosis, Fetal / Q000517:prevention & control*; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006801:Humans; D006932:Hyperbilirubinemia / Q000628:therapy; D007231:Infant, Newborn; D007234:Infant, Premature; D010634:Phenobarbital / Q000627:therapeutic use; D010789:Phototherapy; D011247:Pregnancy; D013223:Statistics as Topic
chemical_list: D001663:Bilirubin; D010634:Phenobarbital
vernacular_title: Pädiatrische Aspekte von Erfolg und Misserfolg der Anti-D-Prophylaxe.