Depression of theophylline elimination following BCG vaccination.
This study investigated the effects of BCG vaccination on the elimination of a single dose of theophylline in twelve healthy female volunteers. Two weeks following BCG vaccination the mean serum theophylline half-life was increased significantly in subjects with a positive Mantoux test compared to the mean half-life determined prior to vaccination. The mean volume of distribution for theophylline was unchanged following vaccination. In two subjects with negative Mantoux tests theophylline half-life was unchanged after vaccination. It is therefore suggested that immunostimulation following BCG vaccination may impair the capacity of the liver to eliminate theophylline.
D000293:Adolescent; D000328:Adult; D001500:BCG Vaccine / Q000276:immunology*; D005260:Female; D006207:Half-Life; D006801:Humans; D013806:Theophylline / Q000378:metabolism*; D014611:Vaccination
D001500:BCG Vaccine; D013806:Theophylline