Safety and efficacy of a three-drug regimen for the treatment of hypertension: hydrochlorothiazide, propranolol, and guanadrel.
Twenty-seven patients with moderate to moderately severe hypertension who had not responded optimally to treatment with a standard step 2 regimen were treated with a three-drug regimen of hydrochlorothiazide, propranolol, and guanadrel. The addition of guanadrel reduced blood pressure to levels significantly below those achieved by the step 2 regimen. The achievement of normotensive blood pressure levels was accompanied by a decrease in the number of adverse effects reported.
D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006146:Guanidines / Q000008:administration & dosage; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011433:Propranolol / Q000008:administration & dosage
D000959:Antihypertensive Agents; D006146:Guanidines; D006852:Hydrochlorothiazide; C004945:guanadrel; D011433:Propranolol