title: Conservation of physico-chemical amino acid properties during the evolution of proteins.
abstract: Based on a similarity ring constructed from a substitution probability matrix, we have analyzed the conservation of some amino acid properties in the evolution of proteins. Refractive index and bulkiness are highly conserved, hydrophobicity and polarity are fairly well conserved while optical rotation appears to be a less relevant property. On the other hand, the analysis of the correspondence between phenotype and genotype shows that the most frequent amino acid substitutions in proteins do not always correspond to the most feasible codon changes. The apparent disagreement between amino acid substitutions in modern proteins and the primordial amino acid-codon assignment is discussed.
mesh_terms: D000596:Amino Acids; D005075:Biological Evolution; D011506:Proteins
chemical_list: D000596:Amino Acids; D011506:Proteins