Effect of scorpion Heterometrus fulvipes venom on metabolism of rat liver mitochondria.
The scorpion venom Heterometrus fulvipes was able to uncouple the state-4 respiration of rat liver mitochondria. The venom caused mitochondrial swelling and was found to be inhibitory to mitochondrial succinate and glutamate dehydrogenases. Bovine serum albumin was able to protect against mitochondrial swelling.
D000818:Animals; D005969:Glutamate Dehydrogenase / Q000037:antagonists & inhibitors; D007700:Kinetics; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D008933:Mitochondrial Swelling / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D012604:Scorpion Venoms / Q000494:pharmacology*; D013385:Succinate Dehydrogenase / Q000037:antagonists & inhibitors
D012604:Scorpion Venoms; D013385:Succinate Dehydrogenase; D005969:Glutamate Dehydrogenase