[Sulfazin in the thermoradiotherapy of experimental tumors].
A possibility of radiosensitization of Pliss' lymphosarcoma and tumor RS-1 by using general hyperthermia with sulfazin was studied. Subcutaneous transfusion of sulfazin to rats caused a rise of the body temperature by 2-2.5 degrees C on the 2nd day after injection with the upkeep of hyperthermia for 3 days. A combined effect of sulfazin and irradiation enhanced the retardation of growth rate of tumors and increased their regression. The lifetime of animals increased significantly. A more noticeable postradiation suppression of mitotic activity was observed.
D000818:Animals; D005260:Female; D005334:Fever / Q000139:chemically induced; D006979:Hyperthermia, Induced; D008113:Liver Neoplasms / Q000532:radiotherapy / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000532:radiotherapy / Q000628:therapy; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000628:therapy*; D011749:Pyrogens / Q000627:therapeutic use*; D051381:Rats; D013444:Sulfisoxazole / Q000627:therapeutic use*
D011749:Pyrogens; D013444:Sulfisoxazole
Sul'fazin v termoradioterapii éksperimental'nykh opukholeĭ.