Three-day clotrimazole therapy for vulvo-vaginal mycosis.
A self-medication therapy with clotrimazole vaginal tablets, application of two tablets at bedtime on 3 consecutive days, was carried out to find out whether vulvo-vaginal mycoses can be treated more effectively and with fewer drop-outs when treatment is simpler and shorter. Our study included forty-one patients, seventeen of whom were in their second or third trimester of pregnancy. There was no significant difference between the efficacy rates in the pregnant (82.4%) and non-pregnant (83.3%) women. In 36 infections caused by various Candida species the cure rate was 91.7%; in 8 infections due to Torulopsis glabrata it was 75%. For thirty-three women with primary infections the cure rate was 84.8% and for eight women with recurrent infections it was 75%. The cure rate for the entire group of patients was 82.9% (thirty-four out of forty-one cases). Failures were seen in six out of thirty cases, i.e. in 16.7%. In one case burning was experienced after the insertion of the vaginal tablet so that treatment was discontinued.
D000328:Adult; D002175:Candida; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy*; D003022:Clotrimazole / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage*; D009181:Mycoses / Q000188:drug therapy*; D011247:Pregnancy; D012008:Recurrence; D014848:Vulvovaginitis / Q000188:drug therapy*
D007093:Imidazoles; D003022:Clotrimazole