Effects of chronic treatment with imipramine, trazodone and electroshock on the behavioural and electroencephalographic modifications induced by clonidine in the rat.
The influence of some typical and atypical antidepressant drugs on the EEG and behavioural effects of clonidine has been studied. The results indicate that chronic administration of imipramine or of electroshock led to the abolition of the behavioural depression and of the EEG synchronisation induced by clonidine. Chronic administration of trazodone was without effect. These results support the hypothesis that chronic treatment with imipramine and electroshock elicits a down-regulation of noradrenergic presynaptic receptors. These structures seem to be largely unaffected by trazodone, which could have a favourable effect on depression through its influence on beta-adrenergic receptors and on the 5-HT system.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D003000:Clonidine / Q000494:pharmacology*; D003863:Depression / Q000503:physiopathology; D004195:Disease Models, Animal; D004569:Electroencephalography; D004597:Electroshock; D006801:Humans; D007099:Imipramine / Q000494:pharmacology*; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014196:Trazodone / Q000494:pharmacology*
D010879:Piperazines; D003000:Clonidine; D007099:Imipramine; D014196:Trazodone