title: A relationship between ascorbic acid and threonic acid in guinea-pigs.
abstract: Threonic acid is a major breakdown product of ascorbic acid used as a food additive. When administered orally to guinea-pigs (100 mg/kg body weight) for periods of 4 or 28 days, it produced a significant fall in the ascorbic acid concentration of certain organs but was without effect on other physiological and biochemical characteristics. The lifespan of scorbutic guinea-pigs was significantly reduced by dietary threonic acid (100 mg/kg body weight). The results indicate that threonic acid may modify the metabolism of ascorbic acid in guinea-pigs.
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000378:metabolism*; D001206:Ascorbic Acid Deficiency / Q000378:metabolism; D002087:Butyrates; D004347:Drug Interactions; D005503:Food Additives / Q000378:metabolism*; D006168:Guinea Pigs; D006885:Hydroxybutyrates / Q000008:administration & dosage / Q000378:metabolism*; D008136:Longevity / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D002087:Butyrates; D005503:Food Additives; D006885:Hydroxybutyrates; C011369:threonic acid; D001205:Ascorbic Acid