Tinnitus and neural activity.
The spontaneous discharge rates of auditory nerve fibers were measured in a group of normal chinchillas and in a group of chinchillas with high-frequency, noise-induced hearing loss. In contrast to normal units, the high-frequency units in the noise-exposed animals tended to have elevated spontaneous discharge rates, high thresholds, and a lack of two-tone inhibition. The change in spontaneous discharge rate across the distribution of nerve fibers is related to models of tinnitus and to human psychophysical data.
D000818:Animals; D001309:Auditory Threshold; D002682:Chinchilla; D004195:Disease Models, Animal; D006317:Hearing Loss, Noise-Induced / Q000503:physiopathology*; D006801:Humans; D011601:Psychophysics; D014012:Tinnitus / Q000503:physiopathology*; D000159:Vestibulocochlear Nerve / Q000503:physiopathology*