Ampicillin effect on lymphatic tissue of mice and its reaction to sheep erythrocytes.
Ampicillin given to B6A F1 mice in multiple doses of 250 mg/kg of body weight caused changes of the thymus with reduction in size, weight and cellularity of the organ, and with a decrease of the migratory activity in vitro of thymocytes derived from mice treated with ampicillin. Ampicillin produced also a stimulatory influence on the reaction of B-lymphocyte zone in the subpopliteal lymph nodes of mice stimulated with sheep erythrocytes, and delayed the development of this reaction in the thymus-dependent zone of these nodes in response to syngeneic erythrocytes.
D000667:Ampicillin / Q000494:pharmacology*; D000818:Animals; D002452:Cell Count; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D004912:Erythrocytes; D008198:Lymph Nodes / Q000166:cytology / Q000187:drug effects*; D008214:Lymphocytes / Q000166:cytology; D051379:Mice; D008815:Mice, Inbred Strains; D009924:Organ Culture Techniques; D009929:Organ Size / Q000187:drug effects; D010950:Plasma Cells / Q000166:cytology; D011961:Receptors, Fc / Q000032:analysis; D012756:Sheep; D013154:Spleen / Q000166:cytology / Q000187:drug effects*; D013950:Thymus Gland / Q000166:cytology / Q000187:drug effects*
D011961:Receptors, Fc; D000667:Ampicillin