The diuretic action of noradrenaline and dopamine in rats with chemical serotoninectomy and central nervous system sympathectomy.
It was demonstrated that dopamine administered into the lateral ventricle of rats with chemically induced sympathectomy of the central nervous system had an evident diuretic effect observed 4 as well as 24 hours after its injection. Noradrenaline, on the other hand, increased diuresis in control rats and in those with chemical serotoninectomy, but only in the first 4 hours of the experiment. Chemical sympathectomy of the central nervous system abolished the diuretic effect of noradrenaline. The results of the experiment confirm the role of mainly dopaminergic receptors in the central regulation of diuresis in this experimental model.
D015115:5,6-Dihydroxytryptamine; D000818:Animals; D002940:Circadian Rhythm; D004231:Diuresis / Q000187:drug effects*; D004232:Diuretics; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009638:Norepinephrine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D013563:Sympathectomy, Chemical; D013997:Time Factors
D004232:Diuretics; D004298:Dopamine; D015115:5,6-Dihydroxytryptamine; D009638:Norepinephrine