[Formulation and clinical test of a novel mucosal adhesive ointment].
A novel mucosal adhesive ointment on the base of partly neutralized polymethacrylic acid methyl ester (Eudispert) was formulated. The flow curves of the ointment show a pseudoplastic quality without any thixotropic effect. The viscosity depended on the kind and concentration of the base. During the clinical studies the pure ointment as well as a tretinoin-preparation for a lichen planus treatment showed no local irritation, good mucosal adhesion and suitable way of application for the patients.
D000180:Acrylic Resins / Q000009:adverse effects / Q000627:therapeutic use*; D000268:Adhesiveness; D004342:Drug Hypersensitivity; D006801:Humans; D008010:Lichen Planus / Q000188:drug therapy; D009092:Mucous Membrane; D009824:Ointments; D011109:Polymethacrylic Acids; D012882:Skin Tests; D014212:Tretinoin / Q000378:metabolism
D000180:Acrylic Resins; D009824:Ointments; D011109:Polymethacrylic Acids; C038300:methylmethacrylate-methacrylic acid copolymer; D014212:Tretinoin
Formulierung und klinische Erprobung einer neuartigen Schleimhauthaftsalbe.