title: Increase in skeletal muscle lipoprotein lipase following endurance training in man.
abstract: The effect of regular physical training on skeletal muscle lipoprotein lipase activity (LPLA) was investigated in 16 healthy men of normal body weight. They trained on cycle ergometers for 8 weeks. During the training period half the group were given the beta-adrenergic receptor blocker propanolol (160 mg/day) and the other half placebo tablets. Muscle tissue samples were taken before the training period and 4 days after the last training session and drug intake to ensure that there were no acute effects of either training or drug treatment. The maximal oxygen uptake (Vo2max, 1/min) increased by 8% with training. LPLA increased by 47% and 31% in the placebo and beta-blockade group, respectively. Capillary density increased by 19% and 17%. The statistical analysis revealed a significant effect of training but not of beta-blockade on these changes. The present longitudinal training study in healthy men confirms the results of cross-sectional studies showing higher muscle LPLA in well-trained than in sedentary men.
mesh_terms: D000328:Adult; D002196:Capillaries; D006801:Humans; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008137:Longitudinal Studies; D008297:Male; D009132:Muscles / Q000098:blood supply / Q000378:metabolism*; D010101:Oxygen Consumption; D010806:Physical Education and Training; D010807:Physical Endurance; D011433:Propranolol / Q000494:pharmacology
chemical_list: D011433:Propranolol; D008071:Lipoprotein Lipase