title: Stability of mezlocillin sodium as determined by high-performance liquid chromatography.
abstract: The stability of mezlocillin sodium solutions in water with either phosphate buffers or other ingredients used in intravenous admixtures (dextrose, fructose, and sodium chloride) has been studied using a stability-indicating high-performance liquid chromatographic method. This assay shows a relative standard deviation of 1.42% based on six injections. The optimum stability was shown at an approximate pH of 4.8, and solutions in dextrose (5%) and sodium chloride (0.9%) were stable for up to 4 days at 25 degrees, 36 days at 5 degrees, and for 60 days at -10 degrees. When refrigerated, the solutions in 5% fructose and 10% dextrose were as stable as those in 5% dextrose.
mesh_terms: D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D008802:Mezlocillin / Q000032:analysis*; D012996:Solutions; D013696:Temperature
chemical_list: D012996:Solutions; D008802:Mezlocillin