Direct observation of molecular ordering of cholesterol in human erythrocyte membranes.
The first observation of the orientation and order of cholesterol in a natural membrane is reported. The 2H-NMR spectrum of [2,2,3,4,4,6-2H6]cholesterol incorporated into human erythrocyte ghosts demonstrates that the orientation and anisotropic motion of cholesterol is very similar in natural and model membranes.
D002784:Cholesterol / Q000097:blood*; D004134:Dimyristoylphosphatidylcholine; D004910:Erythrocyte Membrane / Q000648:ultrastructure*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008563:Membrane Lipids / Q000097:blood*; D008958:Models, Molecular; D008968:Molecular Conformation; D011663:Pulmonary Surfactants
D008563:Membrane Lipids; D011663:Pulmonary Surfactants; D002784:Cholesterol; D004134:Dimyristoylphosphatidylcholine