Inhibitory effect of high density lipoprotein subfractions on the in vitro binding of low density lipoproteins to arterial elastin.
The inhibitory effects of high density lipoprotein (HDL) subfractions on the in vitro complex formation between plasma low density lipoprotein (LDL) and arterial elastin were studied. The inhibitory effects were significantly higher with HDL3 than HDL2, and with HDL-without E than HDL-with E. The inhibitory effect of a phospholipid complex with apoHDL3 was higher than that with apoHDL2. In contrast with the inhibitory effects, the binding abilities of HDL2 and HDL-with E to elastin were significantly higher than those of HDL3 and HDL-without E. These results suggest that the inhibitory effects of HDL subfractions are not due to competitive binding with arterial elastin.
D001011:Aorta / Q000378:metabolism*; D001053:Apolipoproteins / Q000494:pharmacology; D001667:Binding, Competitive; D004549:Elastin / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008075:Lipoproteins, HDL / Q000378:metabolism* / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000378:metabolism*; D010743:Phospholipids / Q000494:pharmacology
D001053:Apolipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D010743:Phospholipids; D004549:Elastin