title: Fertility control in vas occluded rats and the biochemical effects of ascorbic acid feeding.
abstract: A new approach to rapid male sterilization has been studied by giving a single injection of 95% ethanol directly into the vas deferens. It produced an effective block in the lumen. The mating exposure test showed that the males were sterile. Vas occlusion caused an atrophy of the Cauda epididymis. Extensive necrosis and exfoliation of the seminiferous elements were conspicuous. Reduced succinate dehydrogenase, acid phosphatase, vesicular fructose and altered ascorbate turnover pattern could be restored to normal by simultaneous ascorbic acid feeding. In conclusion ascorbic acid feeding plays a definite beneficial role in vas occluded rats. The antiandrogenic effects of vas occlusion could be reversed by simultaneous ascorbic acid feeding.
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism / Q000494:pharmacology*; D004822:Epididymis / Q000378:metabolism; D000431:Ethanol / Q000008:administration & dosage; D007267:Injections; D008297:Male; D051381:Rats; D013076:Sperm Count; D013081:Sperm Motility; D013245:Sterilization, Reproductive / Q000379:methods*; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013737:Testis / Q000378:metabolism*; D014649:Vas Deferens
chemical_list: D000431:Ethanol; D013385:Succinate Dehydrogenase; D000135:Acid Phosphatase; D001205:Ascorbic Acid