Studies of rhenium carboxylates as antitumor agents. Part II. Antitumor studies of bis (mu-propionato) diaquotetrabromodirhenium (III) in tumor-bearing mice.
The neutral, dimeric complexes of rhenium, bis (mu-carboxalato)-diaquotetrahalodirhenium (III) (carboxalato = acetato, propionato, or butyrato and halo = chloro or bromo), were synthesized and survival studies were done on mice bearing P-388 leukemia or B-16 melanoma. The complex bis (mu-propionato) diaquotetrabromodirhenium (III) proved to be the most effective in increasing the life span of the mice. The complex showed some activity against B-16, but virtually none against P-388. The complexes are all quite non-toxic.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D005260:Female; D007941:Leukemia P388 / Q000188:drug therapy; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D008811:Mice, Inbred DBA; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D009942:Organometallic Compounds / Q000627:therapeutic use*; D012211:Rhenium / Q000627:therapeutic use*
D000970:Antineoplastic Agents; D009942:Organometallic Compounds; D012211:Rhenium; C040571:bis(mu-propionato)diaquatetrabromodirhenium (III)