Central nervous system supersensitivity and withdrawal from long-term diphenylhydantoin treatment.
The effects of withdrawal from long-term treatment with increasing doses of diphenylhydantoin (DPH) were studied in rats. The dose of DPH was increased from 5 to 200 mg/kg over 20 days and the animals were tested 72 h after withdrawal. DPH withdrawal induced a leftward displacement of the dose-response curves obtained for the convulsive effects of both picrotoxin and metrazol and decreased the latency of 3-mercaptopropionic acid-induced seizures. These effects were interpreted to be a consequence of supersensitivity of the central nervous system induced by long-term DPH depression.
D000818:Animals; D003292:Convulsants / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
D003292:Convulsants; D010672:Phenytoin