title: Recovery of acetylsalicylic acid and indalpine (LM 5008) after buccal partitioning.
abstract: The recoveries were compared of acetylsalicylic acid (ASA) and indalpine (1) after buccal absorption in three trained human volunteers. Recovery of the poorly lipid soluble ASA was less than 1% at pH 5 or 8, while that of the lipid soluble I was 19% and 13% at pH 5 and 8 respectively. This difference in recovery may represent a difference in their storage within the buccal mucosa dependent on their different lipid solubilities.
mesh_terms: D000042:Absorption; D001241:Aspirin / Q000378:metabolism*; D002610:Cheek; D002626:Chemistry, Pharmaceutical; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009061:Mouth Mucosa / Q000378:metabolism*; D010880:Piperidines / Q000378:metabolism*
chemical_list: D010880:Piperidines; D001241:Aspirin; C018181:indalpine