Microbial hydroxylation of ML-236B (compactin). Studies on microorganisms capable of 3 beta-hydroxylation of ML-236B.
Various microorganisms were tested for capability to hydroxylate of ML-236B at the 3 beta-position. As the result, it was found that this ability was limited to a small group of microorganisms, mainly Zygomycetes in fungi, and Nocardia in actinomycetes.
D000192:Actinomycetales / Q000378:metabolism; D001419:Bacteria / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D005658:Fungi / Q000378:metabolism*; D006900:Hydroxylation; D006903:Hydroxymethylglutaryl CoA Reductases / Q000378:metabolism*; D008148:Lovastatin / Q000031:analogs & derivatives*; D009281:Naphthalenes / Q000378:metabolism*; D009615:Nocardia / Q000378:metabolism; D013045:Species Specificity
D009281:Naphthalenes; C012258:mevastatin; D008148:Lovastatin; D006903:Hydroxymethylglutaryl CoA Reductases