[Protective effect of fosfomycin against renal accumulation of aminoglycoside antibiotics].
Male Wistar rats received 20 mg/kg/day of amikacin (AMK) with or without 200 mg/kg/day of fosfomycin (FOM) for 5 days. Accumulation of AMK in renal lysosome-containing fraction was inhibited by FOM. FOM was reported to interfere with the nephrotoxic properties of aminoglycosides. Our observation supports the finding.
D000583:Amikacin / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism; D000617:Aminoglycosides / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism* / Q000494:pharmacology*; D005578:Fosfomycin / Q000008:administration & dosage / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism*; D007674:Kidney Diseases / Q000139:chemically induced / Q000517:prevention & control; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005578:Fosfomycin; D000583:Amikacin