Phosphine derivatives for selective phosphorylation of nucleoside and their application to oligonucleotide chemistry.
Some new phosphorylating reagents have been developed. They were classified into two types; one reacts selectively to the cis-glycol of ribonucleoside and the other has the selective reactivity to the primary alcohol of nucleoside. The application of these selective phosphorylation reactions to the synthesis of oligonucleotides is described.
D009705:Nucleosides; D009841:Oligonucleotides / Q000138:chemical synthesis*; D010720:Phosphines; D010766:Phosphorylation
D009705:Nucleosides; D009841:Oligonucleotides; D010720:Phosphines