[Prevention of stress-related disorders in the contractile function of non-ischemic areas of the heart during myocardial infarction using gamma-hydroxybutyric acid].
Contractile function of an isolated right auricle of the rat was studied one day after producing an experimental infarction of the left ventricle. It was disclosed that in this non-ischemized heart area there developed marked decrease in myocardial extensibility and depression of contractile function manifesting in an approximately two-fold lowering of the developing tension. These stress-induced disturbances prevented by administering GABA prior to myocardial infarction production. It is assumed that the action of GABA is accounted for by its capability to protect non-ischemized areas of the myocardium against harmful stress action.
D000818:Animals; D006885:Hydroxybutyrates / Q000627:therapeutic use*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012978:Sodium Oxybate / Q000627:therapeutic use*; D013312:Stress, Physiological / Q000503:physiopathology*
D006885:Hydroxybutyrates; D012978:Sodium Oxybate
Preduprezhdenie stressornykh narusheniĭ sokratitel'noĭ funktsii neishemizirovannykh otdelov serdtsa pri infarkte miokarda s pomoshch'iu gamma-oksimaslianoĭ kisloty.