Influence of cis-platinum on some platelet functions in vitro.
Cis-platinum added to citrated platelet rich plasma in vitro did not influence the aggregation of the platelets, their adhesion to glass, their release of platelet factor 4 or availability of platelet factor 3 and acid phosphatase. Neither any effect on the uptake of 14C-serotonin, the reptilase clot retraction or the coagulation system has been observed.
D001792:Blood Platelets / Q000187:drug effects*; D002945:Cisplatin / Q000494:pharmacology*; D003018:Clot Retraction; D004305:Dose-Response Relationship, Drug; D006801:Humans; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D010977:Platelet Factor 3 / Q000032:analysis; D010978:Platelet Factor 4 / Q000032:analysis; D012701:Serotonin / Q000097:blood
D012701:Serotonin; D010977:Platelet Factor 3; D010978:Platelet Factor 4; D002945:Cisplatin