Potentiation of apomorphine-induced gnawing in mice.
1. The association of antagonism of apomorphine-induced climbing with potentiation of apomorphine-induced gnawing in mice has been suggested as a means to detect "atypical" neuroleptics. 2. Clozapine, many compounds with central anticholinergic activity and propranolol have been demonstrated to possess this profile of activities. 3. Pharmacological manipulations with cholinomimetics suggest a cholinergic modulation of the gnawing behavior induced by apomorphine. 4. The observations with propranolol cannot be explained either by a cholinergic link nor by beta-adrenergic antagonism.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology; D001058:Apomorphine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects; D006633:Histamine Antagonists / Q000494:pharmacology; D006801:Humans; D008297:Male; D008409:Mastication / Q000187:drug effects*; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects; D009125:Muscle Relaxants, Central / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology; D010277:Parasympathomimetics / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000187:drug effects; D011976:Receptors, Muscarinic / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects*
D000928:Antidepressive Agents; D006633:Histamine Antagonists; D009125:Muscle Relaxants, Central; D010276:Parasympatholytics; D010277:Parasympathomimetics; D011954:Receptors, Dopamine; D011976:Receptors, Muscarinic; D011433:Propranolol; D001058:Apomorphine