An EEG investigation on the effects of phencyclidine on pentylentetrazol convulsions in rats and rabbits.
The present work deals with an EEG and behavioral study of the effect of phencyclidine against the convulsions due to pentylentetrazol in rats and rabbits. The effects of phencyclidine were compared to those of phenobarbital and trimethadione. A dissociation between the behavioral and electrocortical manifestations of chemically-induced convulsions in the presence of several anticonvulsant drugs has been found.
D000818:Animals; D004569:Electroencephalography; D008297:Male; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors; D010622:Phencyclidine / Q000494:pharmacology*; D010634:Phenobarbital / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D013045:Species Specificity; D014293:Trimethadione / Q000494:pharmacology
D010622:Phencyclidine; D014293:Trimethadione; D010433:Pentylenetetrazole; D010634:Phenobarbital