Subinhibitory concentrations of antibiotics alter fibronectin binding to Staphylococcus aureus.
Fibronectin, a high-molecular-weight glycoprotein, is found in plasma and on mammalian cell surfaces. Recent reports have suggested that bacterial-fibronectin interactions play a role in bacterial attachment to host cells. Subinhibitory concentrations of lincosamines, erythromycin, and chloramphenicol decreased fibronectin binding to Staphylococcus aureus, whereas beta-lactam antibiotics enhanced this interaction.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005353:Fibronectins / Q000378:metabolism*; D008826:Microbial Sensitivity Tests; D011485:Protein Binding / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000378:metabolism
D000900:Anti-Bacterial Agents; D005353:Fibronectins