High affinity binding of the mastoparans by calmodulin.
Calmodulin exhibits high affinity, calcium-dependent binding of the mastoparans--a group of cytoactive tetradecapeptides. The dissociation constants for the peptide-calmodulin complexes determined in 0.20 N KCl, 1.0 mM CaCl2, pH 7.3 are approximately 0.3 nM for mastoparan, approximately 0.9 nM for mastoparan X, and approximately 3.5 nM for Polistes mastoparan. The dissociation constant for the mastoparan-calmodulin complex is the smallest known for any calmodulin binding protein or peptide, suggesting that some type of peptide-calmodulin interaction could be physiologically significant.
D000818:Animals; D001514:Bee Venoms / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000378:metabolism*; D002147:Calmodulin / Q000378:metabolism*; D036341:Intercellular Signaling Peptides and Proteins; D009219:Myosin-Light-Chain Kinase; D009842:Oligopeptides / Q000378:metabolism*; D010455:Peptides; D011485:Protein Binding; D011494:Protein Kinases / Q000378:metabolism; D011817:Rabbits; D013329:Structure-Activity Relationship; D013552:Swine; D014336:Troponin / Q000378:metabolism; D019210:Troponin I; D014422:Turkeys; D014862:Wasp Venoms / Q000378:metabolism*
D001514:Bee Venoms; D002135:Calcium-Binding Proteins; D002147:Calmodulin; D036341:Intercellular Signaling Peptides and Proteins; D009842:Oligopeptides; D010455:Peptides; D014336:Troponin; D019210:Troponin I; D014862:Wasp Venoms; C037500:mastoparan; D011494:Protein Kinases; D009219:Myosin-Light-Chain Kinase