title: [Hemodynamic changes following the injection of lormetazepam under premedication and anesthesia conditions in coronary surgery patients].
abstract: Lormetazepam, a new short-acting benzodiazepine, was studied in 30 patients undergoing coronary artery bypass grafting (10 patients before induction of anaesthesia, 8 patients before extracorporeal circulation, 12 patients during extracorporeal circulation). Before induction of anaesthesia lormetazepam caused only a small reduction in CI, heart rate and a moderate hypoventilation. During anaesthesia (fentanyl, pancuronium bromide, ventilation with N2O/O2 1: 1) there was a decrease in CI (26%), SI (18%), HR (5,7%), dp/dt (15%) and an increase in TSR (25%) and TPR (32%); Part, PAP, PCWP and PRA remained unchanged. There was a small decrease in myocardial oxygen consumption. During ECC lormetazepam increased the arterial perfusion pressure (20%); the priming volume of the oxygenator decreased by 48% at the same time, indicating venous pooling.
mesh_terms: D000768:Anesthesia, General; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D006348:Cardiac Surgical Procedures; D005112:Extracorporeal Circulation; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008140:Lorazepam / Q000031:analogs & derivatives* / Q000494:pharmacology; D011229:Preanesthetic Medication
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; C023842:lormetazepam; D008140:Lorazepam
vernacular_title: Hämodynamische Veränderungen nach Injektion von Lormetazepam unter Prämedikations- und Narkosebedingungen bei koronarchirurgischen Patienten.