Stress-related changes of opiate sensitivity in thermoregulation.
Body temperature reactions to morphine were tested in freely-moving adult rats reared without any previous experience to human handling. These animals reacted to 8 mg/kg morphine s.c. with a biphasic hypo-hyperthermic response. When the rats had been handled for six days, the same dose of morphine induced a monophasic hyperthermic reaction. The results are regarded as evidence that stress-related factors interfere with the thermoregulatory effects of morphine.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D006185:Habituation, Psychophysiologic; D006234:Handling, Psychological; D006801:Humans; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013315:Stress, Psychological / Q000503:physiopathology*
D009020:Morphine