Numerical study on post-stenotic dilatation.
Steady flows and pulsatile flows of a Newtonian fluid through a channel with a rectangular hump were numerically studied as a two-dimensional model of blood flow in a constricted artery. From the numerical calculation, it was shown that one of the hydrodynamic causes of endothelial lesion of artery and post-stenotic dilatation can be found in the large temporal variation of shear stress behind a constricted portion of artery. Local maximum of the pressure there can be seen as secondary factor for the post-stenotic dilatation.
D001157:Arterial Occlusive Diseases / Q000503:physiopathology*; D001158:Arteries / Q000503:physiopathology*; D001794:Blood Pressure; D004108:Dilatation, Pathologic / Q000209:etiology; D006801:Humans; D008433:Mathematics; D008955:Models, Cardiovascular; D012039:Regional Blood Flow; D012212:Rheology; D013314:Stress, Mechanical