Uptake and metabolism of [3H] pteroylglutamic acid by developing chick embryo.
Chick embryos at 9 and 12 days of development were injected into the air space with [3', 5', 7, 9 -3H]pteroylglutamic acid. After various time periods the incorporation of radioactivity into folate derivatives was measured. In the 9-day embryo the label incorporation into longer chain polyglutamates, expressed per gram, was higher than in the 12-day embryo. Since the endogenous content of these compounds was lower at 9 days, the results suggest that, at this stage of development, the turnover of longer pteroylpolyglutamates is more rapid.
D000375:Aging; D000818:Animals; D002642:Chick Embryo; D005492:Folic Acid / Q000031:analogs & derivatives* / Q000378:metabolism*; D011624:Pteroylpolyglutamic Acids / Q000096:biosynthesis*; D013997:Time Factors
D011624:Pteroylpolyglutamic Acids; D005492:Folic Acid