title: Metallic debris arising from prosthetic abrasion: investigation of biodegradation of the materials and physiopathology of the bone.
abstract: The authors investigated the tissue around a failed knee prosthesis which had a metal-on-metal bearing made of chromium-cobalt-molybdenum alloy. Histological examination and the quantitative analysis of metallic particles found in the bone marrow (by fluorescent spectrometry and laser microsound) provided a detailed picture of the quantity, nature and distribution of the wear debris. The type and nature of the tissue response to the presence of the metal particles was determined by fluorescent microscopy and microradiography.
mesh_terms: D000368:Aged; D001673:Biodegradation, Environmental; D001842:Bone and Bones / Q000032:analysis / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005547:Foreign Bodies / Q000175:diagnosis*; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects*; D008670:Metals / Q000032:analysis; D013050:Spectrometry, Fluorescence
chemical_list: D008670:Metals