Lack of effect of alpha-methyldopa on pressor reflexes.
The effects of three cumulative doses (20 mg/kg i.v.) of alpha-methyldopa were studied on pressor responses elicited by the stimulation of the central end of visceral or cutaneous afferences in the anaesthetized dog : vagus, superior laryngeal and saphenous nerves. As clonidine (previous results) alpha-methyldopa failed to modify these cardiovascular reflexes under our experimental conditions.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D066298:In Vitro Techniques; D007823:Laryngeal Nerves / Q000502:physiology; D008297:Male; D008750:Methyldopa / Q000494:pharmacology*; D009475:Neurons, Afferent / Q000502:physiology; D012018:Reflex / Q000187:drug effects*; D014630:Vagus Nerve / Q000502:physiology
D008750:Methyldopa