title: [Suppression of acid secretion and plasma level of a once-daily dose of omeprazole].
abstract: The effect of 5-methoxy-2-[( (4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulphinyl)-1H- benzimidazole (omeprazole) on gastric acid secretion after repeated administration to healthy volunteers has been studied. Omeprazole in a dose of 30 mg given once daily for nine days suppressed acid secretion continuously, the inhibitory effect stabilising after five days. Omeprazole was absorbed and rapidly cleared from plasma; the inhibitory effect was related to the area under the plasma concentration-time curve.
mesh_terms: D000328:Adult; D000897:Anti-Ulcer Agents / Q000097:blood / Q000494:pharmacology*; D001562:Benzimidazoles / Q000097:blood / Q000494:pharmacology*; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008297:Male; D009853:Omeprazole; D010418:Pentagastrin / Q000494:pharmacology
chemical_list: D000897:Anti-Ulcer Agents; D001562:Benzimidazoles; D010418:Pentagastrin; D009853:Omeprazole
vernacular_title: Säuresekretionsverhalten und Plasmaspiegel unter einer mehrtägigen Omeprazol-Gabe.