[Water-electrolyte and hemodynamic aspects of the lasix test in patients with various courses of hypertension].
Forty-two hypertensive patients and seven controls were subjected to the lasix test (20 mg intravenously) followed by the assessment of the time-course of water and electrolytes excretion as well as by arterial pressure measurements. Prior to the test the authors, using isotopic and non-isotopic dilutions, determined the indices of central hemodynamics and sodium, potassium and water distribution in the body. In more than 60% of the patients, the diuretic, sodium- and potassiumuretic response to the administration of lasix was higher than in control. In the patients with essential hypertension, the nature of this response did not depend on the initial level of the arterial pressure, cardiac index, rate of glomerular filtration, content of the total metabolic sodium and potassium, or on the amount and distribution of water in the extracellular and intracellular spaces of the body. The patients with an excessive response to lasix had a significantly lower baseline urine excretion of stable sodium, a higher sodium concentration in the red blood cells and, in cases of stable hypertension, a higher activity of plasma renin as well. Modifications in hypotensive therapy are proposed in relation to the response to lasix administration.
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects; D004232:Diuretics / Q000627:therapeutic use; D004341:Drug Evaluation; D005260:Female; D005665:Furosemide / Q000627:therapeutic use; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D000959:Antihypertensive Agents; D004232:Diuretics; D005665:Furosemide
Vodno-élektrolitnye i gemodinamicheskie aspekty proby s laziksom u bol'nykh s razlichnym techeniem gipertonicheskoĭ bolezni.