title: The biliary excretion and pharmacokinetics of mezlocillin in jaundiced patients with external bile drainage.
abstract: The biliary excretion and pharmacokinetics of mezlocillin have been studied in jaundiced patients with total external bile drainage through a percutaneous transhepatic catheter. In 10 of 11 studies, 2 g mezlocillin intravenously resulted in biliary concentrations sufficient to exceed the minimum inhibitory concentrations of most common biliary pathogenic organisms. In 6 h, 0.2-6.2% of the dose given was recovered in bile. The biliary clearance was 0.21-7.82 ml/min and increased with the duration of biliary decompression. The serum half-life of mezlocillin was prolonged (1.81 +/- 0.23 h, mean +/- SD), and was due to reduced biliary and renal clearance.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001646:Bile / Q000378:metabolism*; D002404:Catheterization; D002779:Cholestasis / Q000378:metabolism* / Q000628:therapy; D004322:Drainage; D004341:Drug Evaluation; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008802:Mezlocillin / Q000378:metabolism*; D008875:Middle Aged
chemical_list: D008802:Mezlocillin