title: Late effects of therapy in children previously treated for leukaemia or malignant tumour.
abstract: The late sequelae of leukaemia and tumour therapy are discussed. The most important and/or the most frequent are neuro-psychologic disturbances, deformities of the bones, the decreased reproduction capacity and the second tumours. Because of the rapidly growing number of cured patients a better knowledge of the occurrence, aetiology, prophylaxis and rehabilitation of these changes is needed.
mesh_terms: D000293:Adolescent; D001921:Brain / Q000187:drug effects / Q000528:radiation effects; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007223:Infant; D007246:Infertility / Q000209:etiology; D007278:Injections, Spinal; D007361:Intelligence Tests; D007938:Leukemia / Q000628:therapy*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects*; D009378:Neoplasms, Multiple Primary / Q000209:etiology; D010907:Pituitary Hormones / Q000097:blood; D011878:Radiotherapy / Q000009:adverse effects
chemical_list: D010907:Pituitary Hormones; D008727:Methotrexate