Levels of vitamin D-metabolites in a case of acro-osteolysis syndrome.
On the initial examinations of a 17-year-old boy with acro-osteolysis syndrome, the levels of serum 25-hydroxycholecalciferol (25OHD) were low, whereas serum levels of 1,25-dihydroxycholecalciferol (1,25(OH)2D) were normal. Administration of 1 alpha-hydroxycholecalciferol (1OHD) failed to improve the osteoporosis, although the serum 25OHD level rose to normal. It is unlikely that impaired bone remodeling due to abnormal vitamin D-metabolism was a primary defect in our patient.
D000293:Adolescent; D001862:Bone Resorption / Q000097:blood*; D002112:Calcifediol / Q000097:blood*; D002117:Calcitriol / Q000097:blood*; D005528:Foot / Q000000981:diagnostic imaging; D006225:Hand / Q000000981:diagnostic imaging; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use; D008297:Male; D010014:Osteolysis / Q000097:blood*; D010024:Osteoporosis / Q000097:blood; D011859:Radiography; D013577:Syndrome
D006887:Hydroxycholecalciferols; D002117:Calcitriol; D002112:Calcifediol; C008088:alfacalcidol