[Role of individual genes in the manifestation of the pathogenicity of influenza viruses].
The study elucidated the role of individual genes in manifestation of mouse pathogenicity by A/PR/8/34 and A/Seal/Massachusetts/1/80. The viruses were studied by the methods of recombination and molecular hybridization. The gene analysis showed that in a permissive system the pathogenicity of A/PR/8/34 strain was not associated with HA and NA surface glycoproteins. Gene P1 plays the decisive role in manifestation of pathogenicity of this strains.
D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D002642:Chick Embryo; D005814:Genes, Viral; D005838:Genotype; D009980:Influenza A virus / Q000235:genetics / Q000276:immunology / Q000472:pathogenicity*; D051379:Mice; D009693:Nucleic Acid Hybridization; D012367:RNA, Viral / Q000235:genetics; D011995:Recombination, Genetic
D000956:Antigens, Viral; D012367:RNA, Viral
Rol' otdel'nykh genov v proiavlenii patogennosti virusov grippa.