On the role of guanyl nucleotides in adenylate cyclase system of embryonic skeletal muscle.
The effects of guanyl nucleotides on the catalytic and catecholamine-stimulated activities of adenylate cyclase in developing chick skeletal muscles were studied. GTP and guanylyl imidodiphosphate stimulate the cyclase catalytic activity already at the early embryonic stages without having potentiating influence on the catecholamine-stimulated activity in embryonic muscle. In a distinct and regular form this effect can be observed only after hatching. Therefore during embryogenesis the coupling function of the GTP-binding component of adenylate cyclase system characteristic of its mature state is not manifested. The effects of the nucleotide suggest that they occur as two independent processes.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002642:Chick Embryo; D002645:Chickens; D004357:Drug Synergism; D004789:Enzyme Activation / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D006160:Guanosine Triphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006165:Guanylyl Imidodiphosphate / Q000494:pharmacology*; D009132:Muscles / Q000196:embryology* / Q000201:enzymology
D006165:Guanylyl Imidodiphosphate; D006160:Guanosine Triphosphate; D000262:Adenylyl Cyclases; D004837:Epinephrine