Tissue distribution of thiopental and diazepam in rats at 71 atmospheres pressure.
35S-thiopental 15 mg/kg and 14C-diazepam 5 mg/kg were injected intravenously in separate groups of rats (n = 6) at 1 ATA air and at 71 ATA air-He. Total radioactivity was measured in the brain, liver, kidney, muscle and fat after 1, 3, 5 and 15 min. The thiopental content was significantly reduced at pressure in the brain at 3, 5 and 15 min. The diazepam content of the brain was significantly reduced at pressure at 1, 5 and 15 min. The liver, muscle and kidney tissue generally contained slightly less of either drug at pressure, particularly at the earliest sampling times.
D000818:Animals; D001273:Atmosphere Exposure Chambers; D001274:Atmospheric Pressure; D003975:Diazepam / Q000008:administration & dosage / Q000378:metabolism*; D006874:Hydrostatic Pressure; D007275:Injections, Intravenous; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013874:Thiopental / Q000008:administration & dosage / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution
D013874:Thiopental; D003975:Diazepam