Total and specific IgE in serum, bronchial lavage and bronchoalveolar lavage of asthmatic patients.
Total and specific IgE were assessed in serum, bronchial lavage (BL) and broncho-alveolar lavage (BAL) of allergic asthmatics and healthy controls. Serum total IgE were found to be correlated with total IgE in BAL but not in BL. Total IgE/K+ ratio in serum and BL was higher in asthmatics than in controls, while the total IgE/albumin ratio was significantly higher in asthmatics than in controls in serum but not in BL and BAL. The mean of specific IgE in serum and BL was significantly higher in the group of patients with positive specific bronchial provocation test (sBPT) than in the group with negative sBPT. Similar results were observed between specific IgE serum level and BL and prick tests (PT), which show that BL does not always reflect the total IgE level of serum; in asthmatics, albumin can not be used to determine the degree of dilution in the recovered fluids; as in the serum, there is agreement between specific IgE in BL and PT or sPBT results.
D000293:Adolescent; D000328:Adult; D000418:Albumins / Q000032:analysis; D000918:Antibody Specificity; D001249:Asthma / Q000175:diagnosis / Q000276:immunology*; D001980:Bronchi / Q000276:immunology*; D001985:Bronchial Provocation Tests; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000032:analysis; D011650:Pulmonary Alveoli / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology; D007507:Therapeutic Irrigation
D000418:Albumins; D007073:Immunoglobulin E; D011188:Potassium