Carbocyclic arabinofuranosyladenine (cyclaradine): efficacy against genital herpes in guinea pigs.
Carbocyclic arabinofuranosyladenine (cyclaradine), a novel nucleoside analog with such desired features as hydrolytic and enzymatic stability, adenosine deaminase resistance, and low systemic toxicity, inhibited the replication of herpes simplex virus types 1 and 2. The 5'-methoxyacetate prodrug form exhibited significant efficacy in the topical treatment of genital infections by herpes simplex virus type 2.
D000212:Acyclovir / Q000627:therapeutic use; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D006168:Guinea Pigs; D006558:Herpes Genitalis / Q000188:drug therapy*; D008297:Male; D013329:Structure-Activity Relationship; D014740:Vidarabine / Q000031:analogs & derivatives* / Q000627:therapeutic use
C014387:carbocyclic arabinosyladenine; D014740:Vidarabine; D000212:Acyclovir