Liver neoplasms after long-term steroid application in rats.
Long-term ingestion of 5 mg/kg body weight ethinylestradiol per esophageal tube induces preneoplasms in the liver of Albino-Wistar-rats. The hepatocellular proliferations could be observed after a test period of 19.5 to 24.5 months. There was no sex difference.
D000310:Adrenal Gland Neoplasms / Q000139:chemically induced; D000818:Animals; D004997:Ethinyl Estradiol / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D010911:Pituitary Neoplasms / Q000139:chemically induced; D011230:Precancerous Conditions / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
C025723:ethinyl estradiol sulfonate; D004997:Ethinyl Estradiol