[Gonadotropic activity of the hypophysis of rats with continuous estrus induced by autotransplantation of the ovaries into the medium with low temperature].
Gonadotropic activity of the adult rat hypophyses with continuous estrus (CE), induced by ovarian autotransplantation into the concha auriculae was studied. The "summary" gonadotropin content in the hypophyses of CE rats, determined on experimental infantile young rats, was higher than in intact estrous animals. LH level, examined by radioimmunoassay, was also higher than in intact estrous rats. LH content was lower in the blood of CE rats, as compared with that of intact estrual animals. In control female rats, prolonged reserpine administration led to the sexual cycle cessation and diestrus arising during 13 days Reserpine did not influence CE in the majority of rats. The drug interrupted CE in some animals not more than for 2 days, followed by CE recovery. The absence of a true reserpine effect upon CE was indicative of estrogenic insufficiency. A single subcutaneous estradiol benzoate injection (15 micrograms/rat) provoked a marked LH secretion in CE rats. It is concluded that CE, induced by ovarian autotransplantation into the concha auriculae is caused by estrogenic insufficiency leading to the absence of ovulation.
D000818:Animals; D001831:Body Temperature; D004431:Ear, External; D004958:Estradiol / Q000494:pharmacology; D004971:Estrus / Q000187:drug effects; D005260:Female; D007668:Kidney; D007986:Luteinizing Hormone / Q000378:metabolism*; D010053:Ovary / Q000637:transplantation*; D010903:Pituitary Gland, Anterior / Q000502:physiology*; D011247:Pregnancy; D051381:Rats
D004958:Estradiol; D007986:Luteinizing Hormone
Gonadotropnaia aktivnost' gipofizov krys s postoiannym éstrusom, obuslovlennym autotransplantatsieĭ iaichnikov v sredu s ponizhennoĭ temperaturoĭ.