Haemodynamic effects of nifedipine in essential hypertension at rest and during exercise.
Fifteen males with previously untreated essential hypertension in WHO stage I, aged 20-64 years were studied on an outpatient basis. Oxygen consumption, heart rate, cardiac in a in a supine and sitting position and during steady state work at 50, 100 and 150 W. Following the haemodynamic study, nifedipine (long-acting form) 40-80 mg daily was given as the sole drug for 3-12 months (mean 11 months) whereupon the haemodynamic study was repeated. Systolic, diastolic and mean arterial pressures fell about 17% at rest supine and sitting and from 15 to 10% at the three different workloads (P less than 0.001). All but one patient demonstrated a fall in mean arterial pressure of 10 mmHg or more. The fall in pressure was associated with a statistically significant (P less than 0.05) reduction in total peripheral resistance (17% during rest and 10 to 16% during exercise). There were no statistically significant changes in oxygen consumption, heart rate, cardiac index or stroke index.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000009:adverse effects / Q000494:pharmacology*; D005082:Physical Exertion; D012146:Rest; D014655:Vascular Resistance / Q000187:drug effects; D014700:Verapamil / Q000494:pharmacology
D014700:Verapamil; D009543:Nifedipine