Effect of administration of anti-bursal extract or perfusate serum on the antibody production in chickens.
Antisera to bursal extracts or perfusates were prepared and the influence of such sera on antibody production in chickens was investigated by the injection of antisera during the embryonic stage. Antisera to cyclophosphamide treated bursal extracts or bursal perfusates were injected on the 15th day of embryogenesis. The level of antibodies produced by chickens treated by these antisera was equal to the controls but IgG antibodies were totally absent. These results suggested that the administration of these antisera inhibited the differentiation of IgM antibody producing cells.
D000818:Animals; D000917:Antibody Formation; D002060:Bursa of Fabricius / Q000187:drug effects / Q000276:immunology*; D002642:Chick Embryo / Q000276:immunology; D002645:Chickens / Q000276:immunology*; D003520:Cyclophosphamide / Q000494:pharmacology; D007106:Immune Sera / Q000494:pharmacology*; D007074:Immunoglobulin G / Q000096:biosynthesis; D008099:Liver / Q000276:immunology; D013154:Spleen / Q000276:immunology
D007106:Immune Sera; D007074:Immunoglobulin G; D003520:Cyclophosphamide