Age differences in effects on blood pressure, flicker fusion frequency, salivation and pharmacokinetics of single oral doses of dothiepin and amitriptyline.
Blood pressure, critical flicker fusion frequency (CFF), salivary flow rate and pharmacokinetics were compared in 7 young healthy volunteers (average age: 22.7 years) and in 7 elderly healthy volunteers (average age: 70.6 years) after single oral doses of the antidepressants dothiepin (DP) 25 mg and amitriptyline (AMP) 25 mg. Systolic blood pressure fell further and the reduction lasted longer in the elderly than in the young after both drugs. The decrease in CFF after AMP 25 mg, and the reduction in salivary flow rate after either DP 25 mg or AMP 25 mg were larger in the elderly than in the young. Plasma levels, T1/2 and Cl of both drugs in the elderly were also higher, longer and smaller, respectively, in the elderly. Clearance was found to be reduced in the elderly. More cautions dosage regimens of these drug should be considered for elderly patients.
D000328:Adult; D000368:Aged; D000375:Aging; D000639:Amitriptyline / Q000378:metabolism / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D003988:Dibenzothiepins / Q000494:pharmacology*; D004308:Dothiepin / Q000378:metabolism / Q000494:pharmacology*; D005425:Flicker Fusion / Q000187:drug effects*; D006801:Humans; D007700:Kinetics; D008297:Male; D012472:Salivation / Q000187:drug effects*
D003988:Dibenzothiepins; D000639:Amitriptyline; D004308:Dothiepin