The effect of fibrinopeptides A and B on the circulatory action of dopamine.
Fibrinopeptides A and B potentiate the hypertensive action of dopamine in the rat and potentiate its hypotensive effects after alpha- and beta-adrenergic blockade. Dopamine receptor blockade with haloperidol completely abolished the effects of FAB. The possible mechanism of the observed effects is discussed.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004032:Diet; D004298:Dopamine / Q000494:pharmacology*; D005340:Fibrinogen / Q000494:pharmacology*; D005344:Fibrinopeptide A / Q000494:pharmacology*; D005345:Fibrinopeptide B / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D005344:Fibrinopeptide A; D005345:Fibrinopeptide B; D005340:Fibrinogen; D011433:Propranolol; D004298:Dopamine; D010646:Phentolamine