Excitatory and inhibitory effects of repetitive stimulation of group I and II extensor afferents on homonymous motoneurons.
The repetitive firing of functionally isolated 143 extensor alpha motoneurons in response to homonymous group I and II tetanizations was studied in decerebrate cats. Of a total sample of 92 group I activated motoneuronal units, 76 motoneurons (82.6%) discharged phasically and 16 motoneurons (17.4%) discharged tonically at threshold or just suprathreshold tetanizations. Only 6 of the phasic motoneurons fired tonically when the stimulus strength was increased within the group I range. The firing rate of 8 phasic motoneurons increased at group I and II stimulations, but they retained their phasic discharge characteristics. The remaining 46 group I activated phasic motoneurons (60.1%) delivered tonic discharges when group II afferents were stimulated. Another group of 16 phasic motoneurons (21.1%) became tonic at group II tetanus, but their tonic discharge was usually interrupted by an inhibitory period, which coincided with an escape reaction of the animal. Out of 38 group II activated motoneuronal units, only 8 (21.1%) motoneurons discharged tonically at threshold or just suprathreshold tetanizations. The repetitive activity of these motoneurons was usually interrupted by an inhibitory period, which coincided with an escape reaction of the animal. This inhibition disappeared after procain application to the GS nerve, and was attributed to dominant inhibitory action of group II afferents mediating the sensation of pain. The remaining 30 (78,9%) motoneurons discharged phasically. Six of them remained phasic even at high threshold group II tetanus. The others gave tonic discharges when the stimulus strength was increased within the group II range. A great percentage of motoneurons discharged regularly with a fixed decoding ratio reflecting monosynaptic excitation. Some motoneurons discharged in multiple bands of impulse intervals due to a variable decoding ratio, which can be attributed to both monosynaptic and polysynaptic reflex discharge elicited by group I and/or II tetanizations. There were 6 motoneurons (4.2%), which discharged repetitively at stimulations of the GS, DP, and SUR nervers. These motoneurons were referred to "common motoneurons", which may participate in multiple motor actions such as fixation of a limb or as a part of the flexor reflex. SOL motoneurons usually discharged tonically at tetanizations within the group I range. The firing rate of these motoneurons usually decreased at tetanizations of the group II afferents of MG nerve. Conversely, tetanization of the group II afferents of SOL nerve usually exerted facilitatory effects on group II activated MG motoneurons.(ABSTRACT TRUNCATED AT 400 WORDS)
D000818:Animals; D002415:Cats; D003655:Decerebrate State / Q000503:physiopathology; D004558:Electric Stimulation; D005071:Evoked Potentials; D009046:Motor Neurons / Q000502:physiology*; D009132:Muscles / Q000294:innervation*; D009433:Neural Inhibition; D009475:Neurons, Afferent / Q000502:physiology*; D012026:Reflex, Stretch; D013116:Spinal Cord / Q000502:physiology