[No effect of particular r-RNA fragments on cytostatic-induced myelosuppression in a rat transplanted tumor model].
Particular r-RNA fragments of E. coli (BLR = Beljanski leukocyte restorer) were given together with a high dose combination chemotherapy of a transplanted neurogenic rat tumor. A restoring effect on the myelopoesis that could be exploited therapeutically was not observed after BLR.
D000818:Animals; D000970:Antineoplastic Agents / Q000037:antagonists & inhibitors*; D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D004347:Drug Interactions; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D007958:Leukocyte Count; D008727:Methotrexate / Q000633:toxicity; D009368:Neoplasm Transplantation; D010976:Platelet Count; D012335:RNA, Ribosomal / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D000970:Antineoplastic Agents; D006454:Hemoglobins; D012335:RNA, Ribosomal; D008727:Methotrexate
Kein Einfluss partikulärer r-RNS-Fragmente auf Zytostatika-induzierte Myelosuppression an einem transplantierten Rattentumormodell.