title: Animal models for hormone-dependent human breast cancer. Relationship between steroid receptor profiles in canine and feline mammary tumors and survival rate.
abstract: The present study shows that canine and feline mammary tumors, like human breast tumors, can be polyreceptive, i.e., they can contain estrogen (ER), progestin (PR), androgen, glucocorticoid, and/or mineralocorticoid cytosol receptors. Furthermore, a follow-up of 45 bitches with mammary carcinoma has indicated that the survival rate is significantly higher in animals with receptor-rich (ER and/or PR) tumors. This indicates that these canine mammary tumors should be evaluated further for their suitability as an animal model for hormone-dependent human breast carcinoma.
mesh_terms: D000818:Animals; D002415:Cats; D004195:Disease Models, Animal; D004285:Dogs; D005260:Female; D008321:Mammary Glands, Animal; D009369:Neoplasms / Q000378:metabolism / Q000401:mortality / Q000662:veterinary*; D011869:Radioligand Assay; D011987:Receptors, Steroid / Q000378:metabolism*
chemical_list: D011987:Receptors, Steroid