Effect of propranolol on the tone of collateral arteries in patients with occlusion of the superficial femoral artery.
The effect of administration of 0.5 mg propranolol into the femoral artery in eight patients with lower limb ischaemia and superficial femoral artery occlusion on collateral arterial resistance was studied in supine and tilted head-up position. Mean blood pressures were recorded directly from the femoral and popliteal artery and femoral blood flow was measured by an indicator dilution technique. After beta-receptor blockade in the supine position the collateral arterial resistance increased by 7 +/- 2%, femoral blood flow decreased 10 +/- 4%, and popliteal artery pressure increased by 4 mmHg (8 +/- 3%). During head-up tilt there was no change in femoral blood flow and collateral arterial resistance after propranolol. The peripheral vasoconstrictor effect of propranolol, therefore, seems not to be harmful to patients with vascular disease.
D001157:Arterial Occlusive Diseases / Q000503:physiopathology*; D003097:Collateral Circulation / Q000187:drug effects; D006801:Humans; D009129:Muscle Tonus / Q000187:drug effects; D011187:Posture; D011433:Propranolol / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects*
D011433:Propranolol