Morphine pretreatment reduces clomipramine effect in mouse forced-swimming test.
It had previously been shown that naloxone inhibits the effect of clomipramine both in a pain test in the forced-swimming test in mice which is proposed as an antidepressant study model. Evidence is reported of a decrease in activity of clomipramine in the forced-swimming test in mice after morphine pretreatment. The hypothesis of an interaction with mu-opiate receptors is considered.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D002997:Clomipramine / Q000037:antagonists & inhibitors*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D013315:Stress, Psychological / Q000503:physiopathology*; D013550:Swimming
D009020:Morphine; D002997:Clomipramine