Silicone as coating material for hemoperfusion.
The effectiveness of activated charcoal in direct hemoperfusion (DHP) has been recognized, but there are still problems with a decrease in solid components of blood and of dimishing adsorption capacity by coating layers on the surface of the sorbents in DHP. In the present study, we have developed activated charcoal derived from thermosetting resin, coated with silicone, and have observed changes in blood components after a 3 hr DHP. Adsorption capacity of the activated charcoal was determined in vitro, and was compared with noncoated charcoal and poly(hydroxyethyl methacrylate) (PHEMA) coated charcoal. Reduction in leukocyte and platelet counts was less with the silicone coated and PHEMA coated charcoals than with the noncoated charcoal. Variations in leukocyte counts and platelet counts were less in DHP with silicone-coated charcoal than with the others. Adsorption of the solid components of blood on the silicone-coated charcoal, examined by scanning electron microscopy after DHP, was very slight, showing its excellent applicability to DHP therapy. The degree of adsorption of various amino acids and related compounds on the silicone-coated charcoal was comparable to that on the noncoated charcoal. Thus, there seems only slight reduction in the degree of adsorption on the silicone-coated charcoal.
D000327:Adsorption; D000596:Amino Acids / Q000097:blood*; D000818:Animals; D002606:Charcoal; D010478:Chemotherapy, Cancer, Regional Perfusion; D004285:Dogs; D004906:Erythrocyte Count; D007700:Kinetics; D008855:Microscopy, Electron, Scanning; D010976:Platelet Count; D012828:Silicones
D000596:Amino Acids; D012828:Silicones; D002606:Charcoal