N-methyl-N-nitro-N'-nitrosoguanidine, guanidine carbonate and guanidine nitrate--different action of single oral doses on cell proliferation in male rats.
MNNG is a strong topically acting carcinogen. Various single oral doses (150, 120, 60 mg/kg) were investigated regarding their effect on the mitotic activity of epithelial tissues in male Sprague-Dawley rats. MNNG inhibits cell proliferation in the forestomach, jejunum and esophagus. Necroses were observed in the forestomach and in the liver (150 mg/kg). Independent of any tissue lesions MNNG produces an elevated mitotic activity of the hepatocytes and in the adrenal cortex. These proliferative effects are not observed when the structurally related noncarcinogenic compounds guanidine carbonate (GC) and guanidine nitrate (GN) are used.
D000284:Administration, Oral; D000302:Adrenal Cortex / Q000166:cytology / Q000187:drug effects; D000818:Animals; D001835:Body Weight; D002455:Cell Division / Q000187:drug effects*; D004947:Esophagus / Q000166:cytology / Q000187:drug effects; D006146:Guanidines / Q000008:administration & dosage / Q000494:pharmacology*; D007583:Jejunum / Q000166:cytology / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000008:administration & dosage / Q000494:pharmacology*; D008938:Mitosis / Q000187:drug effects; D008940:Mitotic Index; D009336:Necrosis; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000166:cytology / Q000187:drug effects
D006146:Guanidines; D008769:Methylnitronitrosoguanidine