[The heparin--tissue plasminogen activator complex and some of its properties].
The complex formation between heparin and tissue plasminogen activator from pig heart "in vitro" was studied. It was shown that in solution heparin and tissue plasminogen activator form a complex with a molar ratio of 1:1. Evidence for the complex formation can be obtained by a shift in the isoelectric point for the activator in the presence of heparin and from IR spectral data. The fibrinolytic and anticoagulating properties of the heparin-tissue plasminogen activator complex were studied.
D000818:Animals; D006493:Heparin / Q000378:metabolism*; D007700:Kinetics; D009206:Myocardium / Q000378:metabolism*; D010960:Plasminogen Activators / Q000378:metabolism*; D011485:Protein Binding; D013055:Spectrophotometry, Infrared; D013552:Swine
D006493:Heparin; D010960:Plasminogen Activators
Kompleks geparin--tkanevyĭ aktivator plazminogena i nekotorye ego svoĭstva.