[Muscle-relaxant effects of intravenously administered micronomicin].
Pharmacological effects, mainly on its muscle-relaxant of micronomicin (MCR) were studied. Intravenous infusion of MCR at a dose of 20 mg/kg/hour did not influence on both respiration rate and cardiovascular functions in anesthetized rabbits. When MCR was injected to anesthetized rabbit at an intravenous dose of 100 mg/kg, a respiratory arrest followed by a cardiac arrest was observed. This effect was antagonized by either treatment with CaCl2 or artificial respiration. In slant test, MCR at a dose of 100 mg/kg (i.v.) in mice induced muscle relaxation. This effect was weakened by slowing the injection speed of the drug. Intravenous injection of MCR potentiated the lethality induced by either d-tubocurarine or succinylcholine. Intravenous injection of MCR influenced on neither pentobarbital sodium-, ethyl ether-, nor halothane-induced anesthesia in mice. From these results, intravenous infusion of MCR at a dose of 20 mg/kg/hour that is considered as 5 approximately 10 times of clinical dose (120 approximately 240 mg/day) did not influence on both respiration and cardiovascular functions.
D000617:Aminoglycosides / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D004357:Drug Synergism; D005839:Gentamicins; D006439:Hemodynamics / Q000187:drug effects; D007263:Infusions, Parenteral; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D009467:Neuromuscular Depolarizing Agents; D010424:Pentobarbital / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects; D013390:Succinylcholine / Q000633:toxicity; D014403:Tubocurarine / Q000633:toxicity
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; D009467:Neuromuscular Depolarizing Agents; D010424:Pentobarbital; D013390:Succinylcholine; C037545:micronomicin; D014403:Tubocurarine