[Change in the cell cycle in a population of Ehrlich ascitic tumor cells as affected by an antiblastoma preparation].
A single treatment of a population of Ehrlich ascites tumour cells with preparation No. 3 at a dose of 120 mg/kg decreases the proliferative pool, inhibits the mitotic activity, (blocking G2-M) and disturbs the mitotic process. The duration of the cell cycle increases 2.7 times, tM increases 9.7 times, tG1-24.1 times, ts increases 1.9 times and tG2-2.9 times. The mitotic rate decreases 20 times and remains slowed-down 10 times after 120 hours. Intensity of DNA synthesis returns to normal after 48 hours and the value of the mitotic index--after 72 hours.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D002453:Cell Cycle / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004353:Drug Evaluation, Preclinical; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D013997:Time Factors
D000970:Antineoplastic Agents; D004273:DNA, Neoplasm; D009943:Organophosphorus Compounds
Izmenenie kletochnogo tsikla v populiatsii kletok astsitnoĭ opukholi Erlikha pod vliianiem antiblastomnogo preparata.