Effect of selected six-mercaptopurine metallo-complexes on adenosine deaminase activity in rat tissues.
Six-mercaptopurine was compared with its palladium and its bismuth complexes with regard to its effects upon the activity of adenosine deaminase (E.C.3.5.4.4.) in rat tissues. Spectrophotometric and high pressure liquid chromatography analyses were utilized in the determinations of enzyme activity. No effect upon enzyme activity was seen to result from treatment with any of the complexes.
D058892:Adenosine Deaminase Inhibitors; D000818:Animals; D001729:Bismuth / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D008297:Male; D015122:Mercaptopurine / Q000031:analogs & derivatives / Q000494:pharmacology*; D009700:Nucleoside Deaminases / Q000037:antagonists & inhibitors*; D009942:Organometallic Compounds / Q000494:pharmacology*; D010165:Palladium / Q000494:pharmacology; D051381:Rats; D013053:Spectrophotometry
D058892:Adenosine Deaminase Inhibitors; D009942:Organometallic Compounds; C017926:palladium-6-mercaptopurine; D010165:Palladium; C037331:bismuth-6-mercaptopurine; D015122:Mercaptopurine; D009700:Nucleoside Deaminases; D001729:Bismuth