Assaying addiction liability of opioids.
A number of procedures are available to assess an opioid's capacity to be positively reinforcing, but each has limitations that could lead to the false conclusion of no addiction potential. The recently developed conditioned place preference (CPP)-test, however, overcomes some of these limitations. Diprenorphine can be used to establish a CPP indicating it has an unsuspected capacity to elicit positive affect. Since diprenorphine antagonizes opioid analgesia and elicits signs of positive affect, the conclusion is confirmed that opioid analgesia and opioid's capacity to be positively reinforcing are separable.
D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D009294:Narcotics / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D019966:Substance-Related Disorders
D009294:Narcotics