Clinical assessment of atracurium using the single twitch and tetanic responses of the adductor pollicis muscles.
Atracurium has been evaluated in anaesthetized patients using the single twitch and tetanic responses of the adductor pollicis muscles. I.v. doses of 0.3-0.9 mg kg-1 produced complete neuromuscular block. In the dose range used mean arterial pressure was only decreased by about 20% of control for a few minutes after 0.9 mg kg-1 which was three times the standard dose. Changes in heart rate were minimal. The onset of maximum block of the tetanic response was faster and the subsequent block was greater and more prolonged than that of the single twitch. Intubation of the trachea could be accomplished when blockade of the tetanic response was complete and at a time when the single twitch was only slightly depressed. It was concluded that the tetanic response provided a more accurate assessment of the time-course of neuromuscular blockade than the single twitch. Infusion studies demonstrated that recovery from full neuromuscular blockade after a 30- or 60-min infusion was as rapid as that after bolus doses of atracurium 0.3-0.9 mg kg-1 and this could be regarded as further evidence of the lack of cumulative effects.
D000328:Adult; D000368:Aged; D001279:Atracurium; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007442:Intubation, Intratracheal; D007546:Isoquinolines / Q000008:administration & dosage / Q000494:pharmacology*; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects*; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage / Q000494:pharmacology*; D013933:Thumb
D007546:Isoquinolines; D009466:Neuromuscular Blocking Agents; D001279:Atracurium