title: The effect of intravenous infusion of Tebonin (Ginkgo biloba) on pial arteries in cats.
abstract: The dilatory effect of intravenously infused Tebonin (extract of Ginkgo biloba) on pial arterial vessels (less than 100 micron diameter), has been measured using a multichannel videoangiometer through a closed cranial window in cats. After 20 minutes there was a significant dilatation of 7% which increased to 21% by one hour. Results from 6 cats treated with 0.3 mg/kg/min. Tebonin were compared with a group of 6 control cats; the same blood gas "steady state" situation applying to both groups. Results imply a cerebral metabolic effect of Ginkgo biloba that induced a slow rise in cerebral blood flow.
mesh_terms: D000818:Animals; D001158:Arteries / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects; D005260:Female; D005419:Flavonoids / Q000494:pharmacology*; D020441:Ginkgo biloba; D008297:Male; D010841:Pia Mater / Q000098:blood supply*; D010936:Plant Extracts; D013997:Time Factors; D014664:Vasodilation / Q000187:drug effects*; D000096983:Ginkgo Extract
chemical_list: D005419:Flavonoids; D010936:Plant Extracts; C063170:Ginkgo biloba extract; D000096983:Ginkgo Extract