Chromosome 1q+ in erythroid and granulocyte-monocyte precursors in a patient with essential thrombocythemia.
A 55-year-old man with essential thrombocythemia had multiplication of bands q21 to q32 of chromosome 1 in all studied mitoses from bone marrow, from unstimulated blood, and from erythroid and granulocyte-monocyte colonies grown in vitro. The multiplication was in the form of triplication in 16 out of 20 mitoses from the marrow and in 4 of 6 mitoses from the blood; the rest showed a duplication of this region. All 20 mitoses from erythroid and granulocyte-monocyte colonies showed the abnormality in the form of duplication. These findings indicate most probably a clonal evolution, the triplication having arisen in the clone with the duplication. This may be associated with early leukemic transformation. The detection of the 1q+ aberration in two different types of hematopoietic colonies indicates the involvement of multipotent stem cells in at least this patient with essential thrombocythemia.
D000328:Adult; D002869:Chromosome Aberrations; D002900:Chromosomes, Human, 1-3; D004900:Erythroblasts / Q000648:ultrastructure; D006098:Granulocytes / Q000648:ultrastructure; D006412:Hematopoietic Stem Cells / Q000648:ultrastructure; D006801:Humans; D008297:Male; D009000:Monocytes / Q000648:ultrastructure; D013920:Thrombocythemia, Essential / Q000235:genetics*