Effect of heparin on lipoprotein profile during parenteral fat infusions.
Long-term administration of Intralipid to infants raises the potential risk of cumulative hyperlipemia. The elimination of lipoproteins from the blood during 3 hours of Intralipid infusion (0.33 grams per kilogram per hour) was investigated in five term infants during two infusion periods without and with heparin. A single intravenous injection of heparin (100 micron per kilogram) preceded the period of Intralipid infusion. During the nonheparin periods levels of triglycerides (L-particles) rose progressively to 1320 +/- 133 milligrams per 100 milliliters plasma, whereas during the heparin periods levels rose more moderately and peaked at 636 +/- 197 milligrams per 100 milliliter plasma (p less than 0.001-0.05). The study suggests that the heparin effect is still apparent for a period of 6 hours and repeated bolus injections may keep triglyceride levels at approximately normal concentrations during constant Intralipid infusion (0.166 grams per kilograms per hour).
D000596:Amino Acids / Q000008:administration & dosage; D003967:Diarrhea / Q000628:therapy*; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage*; D005950:Glucose Solution, Hypertonic; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D008074:Lipoproteins / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D000596:Amino Acids; D005217:Fat Emulsions, Intravenous; D005950:Glucose Solution, Hypertonic; D008074:Lipoproteins; D014280:Triglycerides; D006493:Heparin