Pharmacological study of oral CDP-choline. Interaction with oxotremorine on the parasympathetic system.
The efficacy of an oral treatment of cytidine diphosphate choline (CDP-choline, citicoline, Somazina) is studied with reference to the effects on parasympathetic stimulation provoked by oxotremorine administration in mice. A decrease in sialorrhea, diarrhea and induced hypothermia is observed.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000494:pharmacology*; D003967:Diarrhea / Q000139:chemically induced; D004347:Drug Interactions; D005260:Female; D051379:Mice; D010095:Oxotremorine / Q000494:pharmacology*; D010275:Parasympathetic Nervous System / Q000187:drug effects*; D012472:Salivation / Q000187:drug effects; D013997:Time Factors; D014202:Tremor / Q000139:chemically induced
D003566:Cytidine Diphosphate Choline; D010095:Oxotremorine; D002794:Choline