An effective dose computation model for fractionated radiation dose.
A mathematical model of sensitivity change and cell proliferation for fractionated radiation effect is presented here in which cell proliferation is regarded as part of the virtual recovery of radiated tissues. The obtained values of parameters in this model were applied to reported fractionated radiation data. The values in normal and malignant tissues were not identical. The difference of the values accounts for the increased therapeutic ratio in fractionated radiation. A procedure to optimize fractionated radiation schemes is also presented.
D002455:Cell Division / Q000528:radiation effects; D002470:Cell Survival / Q000528:radiation effects; D005591:Chemical Fractionation; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D008954:Models, Biological; D011879:Radiotherapy Dosage; D012867:Skin / Q000528:radiation effects; D012878:Skin Neoplasms / Q000532:radiotherapy; D013997:Time Factors