title: [Species-specific toxicity of arprinocid in mammals and birds].
abstract: Studied was the species-specific tolerance and the subchronic toxicity of the arprinocid coccidiostatic (9-/2-chloro-6-fluorophenylmethyl/9H-pirineamine) in the form of a 12% premix with trade mark Arpocox, Merk Sharp and Dohme Research Laboratories. It was found that at single oral application arprinocid led to the intoxication of broiler birds at 50 mg/kg, turkey poults-at up to 18 mg/kg, ducklings--up to 18 mg/kg, goslings--up to 6 mg/kg, calves--up to 10 mg/kg, lambs--up to 60 mg/kg, pigs--up to 30 mg/kg. The lethal dose for chickens was over 100 mg/kg, turkeys and duckling--30 mg/kg, and goslings--18 mg/kg. Arprinocid given with the feed to chicken broilers in conc. 60 ppm for 30 days did not lead to side effects. In conc. of 120 and especially 180 ppm there was retardation of growth with birds and inhibition of hemopoiesis. With pigs the preparation in conc. 60 to 180 ppm given with the feed had no effect on the growth and consumption of feeds; in 120 ppm and especially in 180 ppm it inhibited the hemo- and erythropoiesis. With chickens and pigs arprinocid in 180 ppm did not cause degenerative and inflammatory changes in the liver, kidneys, heart, spleen, testes, ovaria, adrenals, thyroid, and skeletal muscles.
mesh_terms: D000225:Adenine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D000818:Animals; D002417:Cattle; D002645:Chickens; D003049:Coccidiostats / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004372:Ducks; D005260:Female; D005777:Geese; D007928:Lethal Dose 50; D008297:Male; D012756:Sheep; D013045:Species Specificity; D013552:Swine; D013997:Time Factors; D014422:Turkeys
chemical_list: D003049:Coccidiostats; C016245:arprinocid; D000225:Adenine
vernacular_title: Niakoi prouchvaniia vŭrkhu vidovospetsifichnata toksichnost na arprinotsid pri bozaĭnitsi i ptitsi.