title: [Efficacy and failure of phenobarbital in the prevention of febrile convulsions. Importance of familial antecedents].
abstract: The authors analyze the value of phenobarbital for prophylaxis of new convulsions in a group of 370 patients who had previously had febrile seizures. Percentage of recurrences in phenobarbital treated cases (4 +/- 0,6 mg/Kg/d) was 18,67%, versus 55,89% in untreated children (p less than 0.001). The presence of family history of epileptic or febrile seizures is a risk factor (p less than 0.01) that facilitates failure of phenobarbital prophilaxis in future febrile seizures.
mesh_terms: D000367:Age Factors; D004827:Epilepsy / Q000235:genetics; D005260:Female; D005311:Fetal Hypoxia / Q000150:complications; D006801:Humans; D008297:Male; D010634:Phenobarbital / Q000627:therapeutic use*; D011247:Pregnancy; D012008:Recurrence; D003294:Seizures, Febrile / Q000209:etiology / Q000235:genetics / Q000517:prevention & control*
chemical_list: D010634:Phenobarbital
vernacular_title: Eficacia y fracaso del fenobarbital en la prevención de las crisis febriles. Importancia de los antecedentes familiares.