Ileal metabolism in vitro of testosterone to 4-androstene-3 alpha, 17 beta-diol.
Testosterone metabolism to 4-androstene-3 alpha, 17 beta-diol by the 800 g supernatant fraction of ileum from male and female rats was investigated. Ileal production of this testosterone metabolite was higher in mature female animals than in mature males. This difference could be eliminated by administration of large doses estradiol-17 beta to mature male rats. Immature animals showed low ileal production of 4-androstene-3 alpha, 17 beta-diol before being weaned from their mother.
D000375:Aging; D000734:Androstenediols / Q000096:biosynthesis*; D000818:Animals; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D007082:Ileum / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013739:Testosterone / Q000378:metabolism*
D000734:Androstenediols; C021287:4-androstene-3,17-diol; D013739:Testosterone; D004958:Estradiol