title: Whole-gut transit time and its relationship to absorption of macronutrients during diarrhoea and after recovery.
abstract: Whole gut transit time (TT) was measured in 68 children aged up to 5 years (29 cholera, 17 rotavirus, 13 enterotoxigenic Escherichia coli, and 9 Shigella) during acute stages of diarrhoea and 2 weeks after recovery. Absorption of calories, fat, protein, and carbohydrates contained in a normal Bangladeshi diet was studied for 72 h after the first appearance of a charcoal marker in the stool, both during acute diarrhoea and 2 weeks after recovery. Mean TT varied from 5.5 to 7.3 h during the acute stage and from 14.1 to 15.5 h during the recovery period of diarrhoea of all aetiologies; the increase in the TT was significant as expected (P less than 0.001). Correlation coefficients were calculated between TT and the coefficients for absorption of fat, nitrogen, calories, and carbohydrates in the acute and recovery stages of cholera, rotavirus, E. coli, and Shigella. No significant relation was found between TT and absorption of nutrients in any stage of diarrhoea of any aetiology. The results of this study suggest that the mechanism for absorption of nutrients is independent of the whole-gut transit time. Further studies are necessary to identify the role of transit of a meal and its absorption along the whole gut.
mesh_terms: D000208:Acute Disease; D002675:Child, Preschool; D003967:Diarrhea / Q000503:physiopathology*; D004032:Diet; D004040:Dietary Carbohydrates / Q000378:metabolism; D004041:Dietary Fats / Q000378:metabolism; D002149:Energy Intake; D005769:Gastrointestinal Motility; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption; D009584:Nitrogen / Q000378:metabolism
chemical_list: D004040:Dietary Carbohydrates; D004041:Dietary Fats; D009584:Nitrogen