title: The experimental production of krimpsiekte in sheep with Tylecodon grandiflorus (Burm.f.) Toelken and some of its bufadienolides.
abstract: Six bufadienolides were isolated from Tylecodon grandiflorus ( Burm .f.) Toelken . The paretic syndrome, krimpsiekte , could be induced in sheep either by repeated oral administration of small quantities of plant material or the intravenous injection of small quantities of certain bufadienolides . A mild to moderate, acute to subacute, multifocal cardiomyopathy was evident in sheep poisoned by both the plant and the bufadienolides .
mesh_terms: D000818:Animals; D002018:Bufanolides / Q000506:poisoning*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D010939:Plant Poisoning / Q000473:pathology / Q000662:veterinary*; D010947:Plants, Toxic / Q000032:analysis; D012756:Sheep; D012757:Sheep Diseases / Q000209:etiology* / Q000473:pathology
chemical_list: D002018:Bufanolides