Effect of prostaglandins on morphine-induced catalepsy in mice.
The effect of prostaglandins (PGs) F1 alpha, F2 alpha, E1, E2, D2, I2, A1, B1 injected into the lateral ventricle of the brain on morphine-induced catalepsy was studied in mice. The PGs were administered in doses of 1 microgram, the dose of morphine was 30 mg/kg intraperitoneally. It was found that PGs E1, E2 and D2 weakened, and F1 alpha, F2 alpha and I2 increased morphine-induced catalepsy. The results of this experiment showed a modifying effect of exogenous PGs on morphine-induced catalepsy, the effect differed depending on the prostaglandin used.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D004357:Drug Synergism; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D011453:Prostaglandins / Q000008:administration & dosage / Q000494:pharmacology*
D011453:Prostaglandins; D009020:Morphine