The effect of TFX (Polfa) on mouse fibroblasts and macrophages in carcinogenicity assays.
TFX (Polfa) was tested for potential carcinogenic effect in in vitro and in in vivo - in vitro tests, using BALB/c mouse cells. Neither mouse embryo culture cells, nor BALB/3T3 fibroblasts cell line exposed to TFX did show any sign of transformation in their pattern of growth and morphology. In the in vivo - in vitro peritoneal macrophages transformation test TFX caused transformation as estimated by alteration in cell morphology and growth behavior, but after s.c. transplantation of the transformed cells into immunoincompetent syngeneic animals as well as into nude mouse, no tumor developed.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D005347:Fibroblasts / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D013949:Thymus Extracts / Q000494:pharmacology*
C019108:TFX; D013949:Thymus Extracts