Effect of in vivo exposure to benzene on the characteristics of bone marrow adherent cells.
The effect of benzene on the adherent cell population, cultured from the bone marrow of exposed mice was investigated in the presence and absence of hydrocortisone. The adherent CFUs from exposed animals did not differ either in numbers or self-replicate ability to those derived from shown exposed animals. Adherent layers from mice exposed to 100 or 400 pp-benzene were devoid of fat cells regardless of the presence or absence of hydrocortisone. Hydrocortisone was shown to influence the proportion of acid phosphatase-positive cells derived from benzene-exposed animals. Those results suggest that benzene exposure may influence the bone marrow stromal cells.
D000135:Acid Phosphatase / Q000032:analysis; D000818:Animals; D001554:Benzene / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D002448:Cell Adhesion / Q000187:drug effects; D002452:Cell Count; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D004781:Environmental Exposure; D006854:Hydrocortisone / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D000135:Acid Phosphatase; D001554:Benzene; D006854:Hydrocortisone