Activity changes of glyoxalases I-II and glutathione reductase in regenerating rat liver.
In regenerating rat liver Glyoxalase I activity shows a significant increase 24-48 hrs after partial hepatectomy. Glyoxalase II activity is significantly increased at 16, 48, and 72 hrs, and shows a transient decrease at 24 hrs after surgery. It is likely that the observed changes in Glyoxalases I and II activities during hepatic regeneration are correlated with the different roles of these enzymes. Glutathione reductase activity, significantly reduced within 8-72 hrs after surgery, does not show any correlation with Glyoxalases. These studied enzyme activities do not display significant changes in the sham-operated animals.
D000818:Animals; D005980:Glutathione Reductase / Q000378:metabolism*; D007700:Kinetics; D007791:Lactoylglutathione Lyase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008115:Liver Regeneration; D008190:Lyases / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013869:Thiolester Hydrolases / Q000378:metabolism*; D000099301:Hydroxyacylglutathione Hydrolase
D005980:Glutathione Reductase; D007791:Lactoylglutathione Lyase; D008190:Lyases; D013869:Thiolester Hydrolases; D000099301:Hydroxyacylglutathione Hydrolase