Gelatin gel beads as an embolic agent.
Gelatin gel beads (GGB) is a compound of a long-chain polypeptide cross-linked with glutaraldehyde. It has been produced exclusively for embolic purposes. The object of the tests reported here was to determine the efficacy of GGB as an embolic agent in dogs as initial studies with rats had shown no acute toxic reaction. Eight dogs were used as subjects. Transcatheter embolization of one kidney in each animal was performed with a suspension of 500 mg of GGB and contrast material. The embolized kidneys were re-examined after one to five weeks. Embolized vessels remained occluded up to five weeks after the procedure. There was mild granulomatous reaction which started to organize at about the third week. The availability of GGB in various sizes when mixed in an isotonic solution makes it unique when compared with other forms of embolic agents. As this agent has now been shown to be a safe and reliable agent in dogs, it can now be used for testing in human subjects.
D000818:Animals; D004285:Dogs; D004621:Embolization, Therapeutic / Q000379:methods*; D005069:Evaluation Studies as Topic; D005782:Gels; D007668:Kidney / Q000473:pathology; D008863:Microspheres; D011859:Radiography; D012077:Renal Artery / Q000000981:diagnostic imaging / Q000473:pathology
D005782:Gels