[Plasma lipids of patients with Duchenne's muscular dystrophy at different stages of the disease].
Blood plasma lipids were studied in patients with Duchenne's myodystrophy. The authors examined 40 patients, aged 3-16 years suffering from different stages of Duchenne's muscular dystrophy. Lipids and fractional composition of plasma phospholipids were investigated by thin-layer chromatography on "Silufol" plates; lipoproteins were assessed by the method of high voltage disk electrophoresis in polyacrylamide gel. The changes in plasma lipids were found to be correlated with both the stage of the myodystrophic process and the type of the disease course. The changes included blood plasma lipemia with increased levels of triglycerides, cholesterol and its esters and also a decrease in phospholipid concentrations with the concomitant redistribution of their fractions. A study of the blood plasma lipoprotein spectrum showed a rise in the values of chylomicrons, remnants and alpha-LP. The data obtained are important for objective determination of the disease stage.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D002788:Cholesterol Esters / Q000097:blood; D003402:Creatine Kinase / Q000097:blood; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D009136:Muscular Dystrophies / Q000097:blood* / Q000235:genetics; D010743:Phospholipids / Q000097:blood; D014280:Triglycerides / Q000097:blood
D002788:Cholesterol Esters; D005230:Fatty Acids, Nonesterified; D008055:Lipids; D008074:Lipoproteins; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol; D003402:Creatine Kinase
Lipidy plazmy krovi u bol'nykh miodistrofieĭ Diushenna na razlichnykh stadiiakh bolezni.