[Effect of decreased blood flow in the liver on blood pressure and on the renin-angiotensin system of the rat].
The effect of reduced blood flow in the liver was studied in acute and chronic experiments on rats. 2 hours after partial constriction of the portal vein in anesthetized rats the mean blood pressure was lower and the plasma renin activity higher than in the control group. There was no relation between the two parameters. 20 weeks after partial constriction of the portal vein in unanesthetized animals the body weight, liver weight and serum albumin fraction were decreased, while the kidney weight was increased significantly and the heart weight insignificantly. The systolic blood pressure of these animals was found to be lower than that of the controls, and their blood pressure response to the i. v. administration of angiotensin II was also lower. In comparison with the control no significant differences were found in the blood renin and substrate levels. The natriuresis proved considerably lower in the animals with the partial constriction of the portal vein.
D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D004231:Diuresis; D008102:Liver Circulation; D008297:Male; D009318:Natriuresis; D009929:Organ Size; D011169:Portal Vein / Q000502:physiology; D011172:Portography; D051381:Rats; D011919:Rats, Inbred Strains; D012084:Renin-Angiotensin System; D013997:Time Factors
Vliianie snizheniiia krovotoka v pecheni na arterial'noe davlenie i na renin-angiotenzinovuiu sistemu krys.