title: Induction of preneoplastic nodules: quantitative predictivity of carcinogenicity.
abstract: Using data from two independent studies, the quantitative predicitivity of carcinogenicity of the liver preneoplastic nodules test was examined. It was compared with the predicitivity of two short-term parameters: the Ames test and acute toxicity. In analyzing the results of both studies, a rather high quantitative predictivity was shown for the preneoplastic nodules (r = 0.43 and r = 0.60, respectively). For one study, the predictivity was approximately of the same order as the internal consistency of the carcinogenicity data (median r = 0.69). The preneoplastic nodules were more predictive than the Ames' test as a statistical trend. The predictivity of the Ames' test has been found to be rather poor; especially in one case where r = 0.10. As expected, acute toxicity was the less predictive short-term parameter.
mesh_terms: D000818:Animals; D002273:Carcinogens; D004353:Drug Evaluation, Preclinical; D008113:Liver Neoplasms / Q000139:chemically induced*; D051379:Mice; D009152:Mutagenicity Tests; D011230:Precancerous Conditions / Q000139:chemically induced*; D051381:Rats
chemical_list: D002273:Carcinogens