title: Decrease in ethanol consumption by naloxone in naive and dependent rats.
abstract: Acute effects of the opiate antagonist, naloxone, on alcohol intake have been examined and compared in naive and behaviorally dependent rats. In naive rats the aversion to an 8% alcohol solution exhibited in a 30 min presentation was selectively augmented by an IP administration of naloxone (1 mg/kg) 30 min before a morning drinking session. In other rats, behavioral dependence was established by 15 days of IG administration of intoxicating doses of alcohol. This dependence was exhibited by a sustained preference for ethanol for 6 days. Naloxone (1 mg/kg) abolishes the acquired preference for ethanol tested during an 8 hour day time presentation. These effects of naloxone on alcohol intake in ethanol naive and dependent rats are interpreted in relation to a general non-specific action of naloxone on preferred or aversive flavoured solutions.
mesh_terms: D000428:Alcohol Drinking; D000430:Alcohol Withdrawal Delirium / Q000188:drug therapy; D000437:Alcoholism / Q000188:drug therapy*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D002755:Choice Behavior / Q000187:drug effects; D006801:Humans; D008297:Male; D009270:Naloxone / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013649:Taste / Q000187:drug effects
chemical_list: D009270:Naloxone