CDP-choline: repeated oral dose tolerance studies in adult healthy volunteers.
Cytidine diphosphate choline (CDP-choline, citicoline, Somazina) was administered to 12 adult healthy volunteer subjects in two short-term chronic oral dose regimens (600 mg X day-1 and 1g X day-1), each of 5 consecutive days, and compared with a corresponding regimen of matched placebo. Transient headaches were the only untoward events recorded, occurring in 4 and 5 subjects, respectively, on the lower and higher dose regimens but in only one subject during placebo administration.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000008:administration & dosage / Q000009:adverse effects*; D004562:Electrocardiography; D004569:Electroencephalography; D005133:Eye Movements / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D011674:Pulse / Q000187:drug effects; D011680:Pupil / Q000187:drug effects; D012018:Reflex / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D013997:Time Factors
D003566:Cytidine Diphosphate Choline; D002794:Choline