title: [Natural peptides and their analogs. XXXI. Synthesis and properties of the retro-analog of methionine-5-enkephalin].
abstract: The synthesis of retro-analog of methionine-5-enkephalin was performed. This peptide is an isomer of the natural methionine-5-enkephalin, but differs from it by opposite direction of peptide linkages between the amino acid residues. The influence of retro-analog on prolactin secretion was studied both in vivo and in vitro. The retro-analog was found to stimulate the prolactin secretion more effectively than methionine-5-enkephalin.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004744:Enkephalin, Methionine / Q000138:chemical synthesis / Q000494:pharmacology*; D008297:Male; D010903:Pituitary Gland, Anterior / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism; D051381:Rats; D013237:Stereoisomerism
chemical_list: D004744:Enkephalin, Methionine; D011388:Prolactin
vernacular_title: Prirodnye peptidy i ikh analogi. XXXI. Sintez i izuchenie svoĭstv retroanaloga metionin-5-énkefalina.