Terminal steps in the biosynthesis of herbicidins, nucleoside antibiotics.
The biosynthetic relationship of the herbicidins produced by Streptomyces saganonensis was studied with blocked mutants by means of a bioconversion method using growing and resting cells. It is proposed that the biosynthetic sequence for herbicidins is; herbicidin G----herbicidin F----herbicidin A. Both herbicidins A and F were converted to herbicidin B by non-enzymatic reactions. Herbicidin G was also converted to herbicidin C non-enzymatically.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001711:Biotransformation; D005285:Fermentation; D011684:Purine Nucleosides / Q000096:biosynthesis*; D013302:Streptomyces / Q000378:metabolism*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D011684:Purine Nucleosides; C013551:herbicidins