Antidyskinetic properties of estrogens.
There is mounting evidence that several gonadal hormones may influence central nervous system. In particular, it has been found that estrogens display an antidopaminergic activity at the level of the extrapyramidal motor system. In this line we have investigated behavioral and biochemical parameters related to nigrostriatal DAergic function. Results obtained further indicate that estrogens display an antidopaminergic activity, by acting on nigrostriatal postsynaptic DAergic receptors. These results may suggest an antidyskinetic activity of estrogens.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced / Q000503:physiopathology; D004958:Estradiol / Q000494:pharmacology; D004967:Estrogens / Q000627:therapeutic use*; D005968:Glutamate Decarboxylase / Q000378:metabolism; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009069:Movement Disorders / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains
D004967:Estrogens; D004958:Estradiol; D005968:Glutamate Decarboxylase; D006220:Haloperidol; D001058:Apomorphine