Arachidonic acid and prostaglandin levels in dithranol erythema: time course study.
Arachidonic acid and prostaglandins were measured in uninvolved psoriatic skin before and after treatment for up to 24 h with dithranol. Prior to treatment, skin exudate contained 2744 ng ml-1 arachidonic acid and 26.4 ng ml-1 PGE2. After treatment with dithranol, the arachidonic acid concentration increased to a maximum of 5556 ng ml-1 at 48 h whilst PGE2 increased to 93.4 ng ml-1 at 12 h and then declined. The erythemal response was apparent at 6-12 h and maximal at 72 h. These results suggest that PGE2 mediates the early development of dithranol erythema.
D000328:Adult; D000368:Aged; D000873:Anthracenes / Q000009:adverse effects*; D000875:Anthralin / Q000009:adverse effects*; D001095:Arachidonic Acids / Q000032:analysis*; D004890:Erythema / Q000139:chemically induced / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011453:Prostaglandins / Q000032:analysis*; D012867:Skin / Q000032:analysis; D013997:Time Factors
D000873:Anthracenes; D001095:Arachidonic Acids; D011453:Prostaglandins; D000875:Anthralin