[Biotransformation and pharmacokinetics of beta-methyl-(1,1'-biphenyl)-4-propanenitrile (LU 20,884) in rats. Spectroscopic studies].
Several compounds of comparison have been examined by their spectroscopic behavior in mass-, 1H-NMR- and IR-spectra of the antiphlogistic active beta-methyl[1,1'-biphenyl]-4-propanenitrile (LU 20,884). Characteristic fragments of alkyl-substituted biphenyls could be determined as well as the localisation of hydroxylated products in 1H-NMR-spectra.
D000818:Animals; D001711:Biotransformation; D001713:Biphenyl Compounds / Q000378:metabolism*; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010666:Phenylpropionates; D051381:Rats; D013055:Spectrophotometry, Infrared
D001713:Biphenyl Compounds; D010666:Phenylpropionates; C038500:3-methyl-(1,1'-biphenyl)-4-propionic acid nitrile
Biotransformation und Pharmakokinetik von beta-Methyl-[1,1'-biphenyl]-4-propannitril (LU 20,884) an Ratten. Spektroskopische Untersuchungen.