[Effect of high doses of tissue plasminogen activator on the hemostatic and fibrinolytic systems].
Intravenous administration of tissue activator plasminogen (TAP), isolated from a frozen pig heart using the technique of Bachman et al., to white rats produced considerable fibrinolysis activation in the euglobulin fraction only. The clot lysis time of this fraction was reduced 2.4-fold within 10 minutes after TAP administration, and high levels of the activator were maintained for 60 minutes. The absence of changes in the fibrinolytic activity of undiluted plasma might be due to TAP binding with antiactivator as the latter's level dropped after 10 minutes. Successive administration of heparin after a therapeutic dose of TAP resulted in decreased heparin activity and inhibited TAP which may be due to the formation of a complex between the two whose specific activity is not manifested in the presence of excessive heparin.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004347:Drug Interactions; D005342:Fibrinolysis / Q000187:drug effects; D006493:Heparin / Q000008:administration & dosage / Q000097:blood; D008297:Male; D010960:Plasminogen Activators / Q000008:administration & dosage* / Q000097:blood; D051381:Rats
D006493:Heparin; D010960:Plasminogen Activators
Vliianie na sistemu gemostaza i fibrinoliz vysokoĭ dozy tkanevogo aktivatora plazminogena.