Hamartomatous polyps in Peutz-Jeghers syndrome. A light-, histochemical, and electron-microscopic study.
Multiple hamartomatous polyps from two patients with Peutz-Jeghers syndrome were studied using histochemical, electron-microscopic, and light-microscopic means. Using normal intestinal mucosa as control, mucosubstances containing sulfate, hexose and glycogen, as well as neutral and acid mucins, were detected. Electron-microscopic findings in different cellular populations of hamartomatous and normal mucosa were also evaluated. The results indicated the hamartomatous nature of such polypoid formations in Peutz-Jeghers syndrome. Review of the literature supports the possibility of genetic predisposition of these patients to develop unusual types of neoplasms in unexpected localizations.
D000328:Adult; D002648:Child; D003111:Colonic Polyps / Q000473:pathology; D005260:Female; D006003:Glycogen / Q000032:analysis; D006222:Hamartoma / Q000473:pathology; D006601:Hexoses / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D007413:Intestinal Mucosa / Q000032:analysis; D008297:Male; D009077:Mucins / Q000032:analysis; D010580:Peutz-Jeghers Syndrome / Q000235:genetics / Q000378:metabolism / Q000473:pathology*; D013431:Sulfates / Q000032:analysis
D006601:Hexoses; D009077:Mucins; D013431:Sulfates; D006003:Glycogen