title: Effects of body weight reduction and food deprivation on cocaine self-administration.
abstract: The present experiments attempted to study the effects of food deprivation and body weight reduction on cocaine self-administration. Rats whose body weight was reduced to 80% free feeding weight (FFW) with 23 hours' food deprivation increased cocaine intake by 30-fold compared to 100% FFW animals. The results demonstrated that, in rats, body weight reduction and the state of food deprivation interact to further enhance self-administration of cocaine. From the practical point of view, the results suggest that there may be an increased risk of drug dependence with patients taking stimulants to control body weight.
mesh_terms: D000818:Animals; D001835:Body Weight; D003042:Cocaine / Q000008:administration & dosage*; D005508:Food Deprivation; D006801:Humans; D008297:Male; D051381:Rats; D012646:Self Administration; D019966:Substance-Related Disorders / Q000209:etiology
chemical_list: D003042:Cocaine