[Carcinogenic effect of 1-phenyl- and 1-(pyridyl-3)-3,3-dimethyltriazenes and 1-phenyl- and 1-(pyridyl-3)-3,3-diethyltriazenes in single pre- and postnatal administration to BD IX rats].
1-Phenyl- and 1-(Pyridyl-3)-3,3-dimethyltriazene and the corresponding 3,3-diethyl-derivatives have been investigated for carcinogenic effects in BD IX rats following pre- and postnatal exposure. In the prenatal experiments these compounds induce no tumors in the progeny when administered on day 10 post coitum. A pronounced neurotropic carcinogenic activity was observed in the progeny only with 1-(pyridyl-3)-3,3-diethyltriazene, when administered on day 15 p.c., while the other three triazenes tested were negative or only weakly active. Carcinogenic effects were observed with the two pyridyltriazenes, when administered on day 20 p.c., shortly before birth. All four triazenes were potently carcinogenic when administered postnatally on day 1, 10, 30, 60 and 90, respectively, post partum. The neurotropic carcinogenic activity was especially pronounced with 1-(pyridyl-3)-3,3-diethyltriazene. Observed tumor rates in heart and kidney depended upon the used triazene and to a great extend upon the age of the treated animals.
D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D005333:Fetus / Q000187:drug effects; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000401:mortality; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014226:Triazenes / Q000494:pharmacology*
D002273:Carcinogens; D014226:Triazenes; C040759:1-(3-phenyl)-3,3-diethyltriazene; C009126:1-(3-pyridyl)-3,3-dimethyltriazene; C040762:1-(3-pyridyl)-3,3-diethyltriazene; C008848:1-phenyl-3,3-dimethyltriazene
Karzinogene Wirkung von 1-Phenyl- und 1-(Pyridyl-3)-3,3-dimethyl-triazen sowie 1-Phenyl- und 1-(Pyridyl-3)-3,3-diäthyl-triazen bei einmaliger prä- und postnataler Verabreichung an BD IX Ratten.