Tolerance develops to LSD while the drug is exerting its maximal behavioral effects: implications for the neural bases of tolerance.
Tolerance to a test dose of 50 mg/kg of LSD occurred within 0.5-1.0 h following an initial dose of 10 mg/kg of the drug, using limb flicking and abortive grooming as behavioral indices in the cat. These findings represent an example of very rapidly developing drug tolerance using a behavioral index. These data are discussed within the context of hypotheses concerning the neurochemical bases of tolerance to LSD.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002415:Cats; D002490:Central Nervous System / Q000187:drug effects*; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D005260:Female; D006120:Grooming / Q000187:drug effects; D008238:Lysergic Acid Diethylamide / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male
D008238:Lysergic Acid Diethylamide