Heme oxygenase activity is decreased by D-penicillamine in neonates.
A 3-day D-penicillamine treatment of neonatal rats caused a significant decrease in heme oxygenase activity. This change was not observed in adult rats. The data indicate age-related differences in the effects of D-penicillamine.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010396:Penicillamine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D006899:Mixed Function Oxygenases; D006419:Heme Oxygenase (Decyclizing); D010396:Penicillamine