Modification of immune responsiveness to tumour grafts (enhancement or inhibition) induced in mice by allogeneic embryos.
Immune reactivity of the female recipients, made artificially pregnant, of fully allogeneic embryos was investigated. Allogeneic blastocysts were transferred into hormonally synchronized foster mothers in two strain combinations A (H-2a)--CBA (H-2k) and C57BL/6 (H-2b)--DBA/2 (H-2d). Immunogenicity was tested by growth of tumours Sa 1 (syngeneic with A strain recipients) and EL 4 (syngeneic with C57BL/6 strain recipients). Allogeneic blastocysts implanted in the host's uterus are able to elicit a stronger immune response than in semi-syngeneic pregnancies. The immune reaction was manifested by enhanced growth of tumour Sa 1 and accelerated rejection of EL 4.
D000818:Animals; D004624:Embryo Transfer; D004622:Embryo, Mammalian / Q000276:immunology; D005260:Female; D006082:Graft Enhancement, Immunologic; D006084:Graft Rejection; D006085:Graft Survival; D006183:H-2 Antigens / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000276:immunology; D011270:Pregnancy, Animal; D011555:Pseudopregnancy / Q000276:immunology; D014184:Transplantation, Homologous
D006183:H-2 Antigens