title: [Effect of 5-bromodeoxyuridine concentration on sister chromatid exchange frequency in consecutive replication cycles].
abstract: A yield of single and twin sister chromatid exchanges (SCE) in Chinese hamster cells incubated at different concentrations of 5'-bromodeoxyuridine (BrdUrd) has been studied. The ratio of SCEs formed in the second and in the first cycle has been discovered to be dependent on the dose of BrdUrd; it is 1.5:1 for the high concentration of BrdUrd and 1:1 for the lowest one. The authors arrived at a conclusion that the observed level of SCEs--0.1 per chromosome per cycle for the lowest concentration is spontaneous.
mesh_terms: D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002453:Cell Cycle; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D012854:Sister Chromatid Exchange / Q000187:drug effects*
chemical_list: D001973:Bromodeoxyuridine
vernacular_title: Vliianie kontsentratsii 5-bromdezoksiuridina na chastotu sestrinskikh khromatidnykh obmenov, obrazuiushchikhsia v posledovatel'nykh tsiklakh replikatsii.