Further studies on superoxide dismutase activities of macrocyclic polyamine complexes of copper(II).
The superoxide dismutase (EC 1.15.1.1) activities of new series of macrocyclic complexes with copper(II) have been measured. Chemical modifications in macrocyclic ring size, donor atom, donor atom number, substituents on the macrocyclic skeletons, and length of bridges linking two macrocycles are shown to have profound effects on the superoxide dismutase activities of the metal complexes. The quantitative measurement by the standard xanthine-xanthine oxidase assay, which depends on the conversion of nitroblue tetrazolium to formazan, has been corroborated by a direct assay method using an oxygen electrode.
D002384:Catalysis; D055598:Chemical Phenomena; D002621:Chemistry; D003300:Copper / Q000494:pharmacology*; D011073:Polyamines / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase
D011073:Polyamines; D003300:Copper; D013482:Superoxide Dismutase; D014969:Xanthine Oxidase