[Effect of enkephalins on the motor activity and behavior of rats in "open field" conditions].
It is shown that leu-enkephalin, injected intraperitoneally in doses of 0.15 and 1.0 mg/kg lowers general motor activity of rats in "Animex" apparatus in 10-30 min after the injection. D-substituted analogue of leu-enkephalin D-Ala-D-Leu-enkephalin (0.15 mg/kg) lowers the motor activity already in first 5 min after injection. Met-enkephalin, DALA and morphine in a dose of 0.15 mg/kg do not change the general motor activity of rats in "Animex". Concentration raise of opiate ligands to 1.0 mg/kg does not lead to the development of significant effect in the case of met-enkephalin, but elicits an increase of motor activity under the action of morphine to 25-30 min after injection. During the study of animals' behaviour in "the open field" the leu-enkephalin and D-Ala-D-Leu-enkephalin lower the level of certain emotional reactions in rats, while met-enkephalin and DALA are not effective.
D000818:Animals; D004644:Emotions / Q000187:drug effects*; D004743:Enkephalin, Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives*; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives / Q000494:pharmacology; D004745:Enkephalins / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D013329:Structure-Activity Relationship
D004745:Enkephalins; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; C022118:enkephalinamide-Met, Ala(2)-; D016308:Enkephalin, Leucine-2-Alanine; C030279:enkephalinamide-Leu, Ala(2)-
Vliianie énkefalinov na dvigatel'nuiu aktivnost' i povedenie krys v usloviiakh "otkrytogo polia".