[Transdermal scopolamine for postoperative vomiting: a new form of premedication?].
The author has used scopolamine-TTS, a fundamentally new therapeutic system, exclusively as anti-emetic premedication in 100 patients undergoing surgery with anaesthesia. Application is simple and non-invasive. The results are encouraging: in the first 12 hours after operation the antiemetic therapy had to be extended with i.V.-domperidone because of insufficient effect in only 9% of the patients. 24 hours later still 8% of the patients had slight nausea without vomiting. Slight side effects (delayed waking, accommodation disturbances, dry mouth) occurred in 3 to 30% of the patients. The transdermal therapeutic system opens basically new pharmacological and clinical perspectives.
D000287:Administration, Topical; D000932:Antiemetics / Q000008:administration & dosage*; D004341:Drug Evaluation; D006801:Humans; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication; D011300:Preoperative Care; D012601:Scopolamine / Q000008:administration & dosage* / Q000009:adverse effects; D014839:Vomiting / Q000517:prevention & control*
D000932:Antiemetics; D012601:Scopolamine
Transdermales Scopolamin gegen postoperatives Erbrechen: Eine neue Prämedikationsformel?