Exercise-induced increments in plasma levels of propranolol and noradrenaline.
Exercise-induced changes in the plasma levels of propranolol and noradrenaline were determined in nine volunteers. Total plasma propranolol levels were increased during submaximal treadmill exercise, with exercise-induced increments of 13 +/- 4% at 4 h after the last dose, 18 +/- 7% at 9 h and 41 +/- 5% at 16 h. Exercise-induced increments in plasma propranolol were observed after single as well as repeated doses. During exercise, increments in plasma propranolol were correlated temporally with changes in plasma noradrenaline. Exercise-induced increments in plasma noradrenaline were greater during propranolol administration than during placebo periods. The changes in plasma propranolol concentration during exercise may reflect a redistribution of propranolol at its site(s) of action.
D006801:Humans; D009638:Norepinephrine / Q000097:blood* / Q000378:metabolism; D005082:Physical Exertion; D010953:Plasma Volume; D011433:Propranolol / Q000097:blood* / Q000494:pharmacology
D011433:Propranolol; D009638:Norepinephrine