Chronic electroconvulsive treatment enhances the density of [3H]prazosin binding sites in the central nervous system of the rat.
Chronic electroconvulsive treatment (ECT) given daily for 10 days enhanced the density of [3H]prazosin binding sites in the membranes from the spinal cord and cerebral cortex of the rat 24 h after the last shock. Similar effect (investigated only in cortical membranes) was produced by spaced ECT (5 shocks at 72 h intervals). The effect was preceded by a decrease in the density of [3H]prazosin binding sites, observed 2 h after the last shock and disappeared within 48 h.
D000818:Animals; D001665:Binding Sites; D002462:Cell Membrane / Q000378:metabolism; D002540:Cerebral Cortex / Q000378:metabolism*; D004597:Electroshock; D006801:Humans; D007700:Kinetics; D008297:Male; D009928:Organ Specificity; D011224:Prazosin / Q000378:metabolism*; D011799:Quinazolines / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000378:metabolism*; D013315:Stress, Psychological / Q000503:physiopathology*
D011799:Quinazolines; D011224:Prazosin