[Inhibition of basal acid secretion by trimethyldesoxy-prostaglandin E2 in humans].
The effect of graded oral doses of trimethyldesoxy-prostaglandin E2 (Ro 21-6937) on basal acid secretion in healthy volunteers was tested over a time period of 6 h. Basal acid output was reduced by 80% after 1500 micrograms Ro 21-6937. Half-maximal inhibition was achieved by 700 micrograms Ro 21-6937. 250 micrograms of this prostaglandin E2 analog showed no detectable antisecretory activity.
D000328:Adult; D003864:Depression, Chemical; D015232:Dinoprostone / Q000031:analogs & derivatives*; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology; D013997:Time Factors
D011459:Prostaglandins E, Synthetic; C038879:trimoprostil; D015232:Dinoprostone
Hemmung der Nüchternsekretion durch Trimethyldesoxy-prostaglandin E2 beim Menschen.