Comparative effects of estradiol stereoisomers on pimozide-induced catalepsy, locomotor activity and body-weight in the rat.
The effects of 17-alpha and 17-beta estradiol were compared at three dose levels on locomotor activity, pimozide-induced catalepsy, and changes in body weight. At 10 micrograms/kg/day they increased locomotor activity to a similar degree but at 5 and 1 microgram/kg/day the beta form was mor effective. However the alpha isomer failed to potentiate catalepsy, or reduce body weight, even at the highest dose whereas 17-beta estradiol did both. From these and other results it is suggested that estradiol might act on intracellular receptors and not by changing catecholamine metabolism.
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D002375:Catalepsy / Q000139:chemically induced / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000031:analogs & derivatives / Q000502:physiology*; D005260:Female; D006801:Humans; D009043:Motor Activity / Q000187:drug effects*; D010868:Pimozide / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D010868:Pimozide; D004958:Estradiol