Hypersensitivity to the tremorogenic action of nicotine in rats withdrawn from ethanol.
The tremorogenic effect of nicotine was studied in control rats and in rats withdrawn for 16-48 h from chronic ethanol administration. The intensity of tremor was measured electronically. Rats withdrawn from ethanol showed a marked hypersensitivity to the tremorogenic action of nicotine. Propranolol abolished the nicotine-induced tremor in the control rats. Propranolol did not, however, reduce the intensity of nicotine-induced tremor in rats withdrawn from ethanol. Thus, the observed hypersensitivity does not seem to be mediated by a sympathetic beta-adrenergic mechanism.
D000818:Animals; D000431:Ethanol / Q000633:toxicity*; D006801:Humans; D008297:Male; D009538:Nicotine / Q000633:toxicity*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013375:Substance Withdrawal Syndrome; D014202:Tremor / Q000139:chemically induced*
D000431:Ethanol; D009538:Nicotine; D011433:Propranolol