title: Bacterial modulation of the cellular immune response in mice. I. The course of lymphocytic choriomeningitis virus infection in Bordetella pertussis vaccine pretreated mice with physiological thymus involution.
abstract: The cellular immune response to lymphocytic choriomeningitis virus infection was found to be normal in 6-month-old mice with physiological thymus involution, while it was reduced in 18-month-old mice. The Bordetella pertussis vaccine elicited immunosuppression in 6-month-old mice with normal immunological responsiveness, while it failed to affect the physiologically diminished cellular immune response in 18-month-old mice. The extent of immunosuppression elicited by the vaccine changed parallel to its concomitant spleen hypertrophy inducing effect.
mesh_terms: D000367:Age Factors; D000818:Animals; D005260:Female; D006984:Hypertrophy; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D008216:Lymphocytic Choriomeningitis / Q000276:immunology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size / Q000187:drug effects; D010567:Pertussis Vaccine / Q000276:immunology*; D013154:Spleen / Q000473:pathology; D013950:Thymus Gland / Q000502:physiology*; D014611:Vaccination
chemical_list: D010567:Pertussis Vaccine