N4-aminocytidine: formation, reactivity, and mutagenicity.
N4-Aminocytidine was readily formed on treatment of cytidine with hydrazine-bisulfite under mild conditions. This reaction can be carried out for cytosines in polynucleotids as well. The nucleoside N4-aminocytidine was strongly mutagenic to bacteria and phage. The transformation of cytosines in polynucleotides into N4-aminocytosines is a convenient method for generating reactive groups in the polymer.
D055598:Chemical Phenomena; D002621:Chemistry; D003562:Cytidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D006834:Hydrazines; D009153:Mutagens
D006834:Hydrazines; D009153:Mutagens; C038769:N(4)-aminocytidine; D003562:Cytidine