Serum estriol level during treatment with betamethasone in the last trimester of human pregnancy.
A comparison was made between betamethasone disodiumphosphate/betamethasone acetate (Celeston) and betamethasone disodiumphosphate (Celestona) in antenatally prophylactic treatment of respiratory distress syndrome syndrome (RDS). Altogether 65 pregnant women in the last trimester of pregnancy were treated with the first-mentioned drug and 62 with the second. The RDS-preventive effect was the same in the two groups. Celeston has a much longer depressive effect on the level of plasma estriol than has Celestona. Use of this drug, betamethasone disodiumphosphate, is therefore recommended in the prophylaxis against RDS.
D001623:Betamethasone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004964:Estriol / Q000097:blood*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D012127:Respiratory Distress Syndrome, Newborn / Q000517:prevention & control*
C018230:betamethasone acetate phosphate; C028994:betamethasone sodium phosphate; D001623:Betamethasone; D004964:Estriol