Comparative gastric irritation by two buffered acetylsalicylic acid formulations and acetylsalicylic acid. A gastric potential difference analysis.
In a single dose clinical investigation two buffered acetylsalicylic acid formulations (Ascriptin and Ascriptin A/D) were shown to be significantly less irritating to the human gastric mucosa than acetylsalicylic acid, and no more irritating than a pharmacologically inert placebo. The measurements were taken using a minimally invasive method for recording transmural gastric potential difference changes versus time.
D000328:Adult; D001241:Aspirin / Q000008:administration & dosage / Q000009:adverse effects*; D002021:Buffers; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D007509:Irritants; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D013272:Stomach Diseases / Q000139:chemically induced*; D013997:Time Factors
D002021:Buffers; D007509:Irritants; D001241:Aspirin