Effects of various anthelmintics on larval stages of Nematospiroides dubius (Nematoda).
The effects of six anthelmintics on larval stages of Nematospiroides dubius in mice were assessed. Levamisole phosphate, at a dose of 100 mg/kg administered per os 6 days postlarval inoculation (PI), effected greater than 98% reduction in worm burdens. At dose rates one log2 higher, 50% mortality of the mice occurred. Ivermectin, given per os at a dose rate of 5 mg/kg, removed all of the worms when administered either on Day 3 or 6 PI. No toxicity was observed even at the highest dose tested (25 mg/kg). Albendazole, cambendazole, pyrantel pamoate, and fenbendazole, all given per os at a dose of 100 mg/kg on day 6 PI, allowed from 52 to 75% of the worms to develop to adulthood. Ivermectin emerged as the larvicidal drug of choice owing to its high efficacy and undetectable toxic side effects.
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005260:Female; D007814:Larva / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D009348:Nematoda / Q000187:drug effects / Q000254:growth & development*; D009349:Nematode Infections / Q000188:drug therapy*
D000871:Anthelmintics