title: [Hemodynamic and humoral changes in long-distance athletes].
abstract: Cardiac anatomy and function, and some biohumoral parameters, have been examined in 11 long-distance olympic runners, and in 11 healthy untrained control subjects. Echocardiographic methods and computed reading of tracings were adopted. Long-distance runners were also studied within 2 minutes after the end of a 30 Km race. At rest, the athletes had thicker interventricular septa and, posterior walls, higher left ventricular mass index, larger end-diastolic dimensions, cardiac index and stroke index compared to the untrained subjects (all P less than 0.01). Resting heart rate was lower in runners (P less than 0.01). In runners, competitive exercise test induced significant haemodynamic changes (increases in cardiac index, heart rate, stroke index, ejection fraction [all P less than 0.01], decreases in end-systolic dimensions and peripheral vascular resistance [both P less than 0.01]). After exercise, runners showed massive increases both of norepinephrine and epinephrine serum levels (measured in 4 subjects), an increase, in haematocrit and plasma glucose concentration, and a decrease in plasma potassium concentration (all P less than 0.01). In conclusion, olympic long-distance runners have increased cardiac dimensions and wall thickness at rest as compared with healthy untrained subjects matched for age and resting blood pressure. In the former group, a competitive long-distance test results in marked haemodynamic changes, with massive increase in plasma catecholamine concentration and concomitant reduction in plasma potassium concentration. This combination is potentially hazardous, and warrants further investigation.
mesh_terms: D002302:Cardiac Output; D002395:Catecholamines / Q000097:blood; D005260:Female; D006321:Heart / Q000033:anatomy & histology / Q000502:physiology*; D006339:Heart Rate; D006801:Humans; D008297:Male; D011188:Potassium / Q000097:blood; D012420:Running
chemical_list: D002395:Catecholamines; D011188:Potassium
vernacular_title: Modificazioni emodinamiche ed umorali in atleti di fondo.