title: The effects of droperidol and diazepam on the neural excitation of ketamine hydrochloride.
abstract: The effects of neuroleptics (droperidol and diazepam) were studied on the neural excitation by ketamine hydrochloride by means of the c-fiber reflex, in the spinal cat and the intact cat. Results can be summarized as follows: 1) Ketamine hydrochloride 125-500 micrograms/Kg i.v. facilitated the neural activity on the c-fiber reflex of the intact cat, but it depressed that of the spinal cat. 2) Droperidol 50-250 micrograms/Kg i.v. and diazepam 50-250 micrograms/Kg i.v. did not influence the neural activity on the c-fiber reflex of the intact cat, but it depressed that of the spinal cat. 3) Droperidol 125 micrograms/Kg i.v. followed by ketamine hydrochloride 125 micrograms/Kg i.v. facilitated the neural activity of the intact cat c-fiber reflex. 4) Diazepam 50 micrograms/Kg i.v. followed by ketamine hydrochloride 250 micrograms/Kg i.v. did not influence the neural activity of the intact cat c-fiber reflex. These data suggested that the neural excitation of ketamine hydrochloride was depressed by diazepam and that a small dose of droperidol did not depress the neural excitation of the intact cat.
mesh_terms: D000818:Animals; D002415:Cats; D003975:Diazepam / Q000494:pharmacology*; D004329:Droperidol / Q000494:pharmacology*; D005260:Female; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects; D009474:Neurons / Q000187:drug effects*; D012018:Reflex / Q000187:drug effects
chemical_list: D007649:Ketamine; D004329:Droperidol; D003975:Diazepam