Increased efficacy of liposomes-encapsulated praziquantel in treatment of opisthorchiasis in hamsters.
An increased efficacy of liposomes-encapsulated praziquantel was observed in the treatment of hamster opisthorchiasis. A single intracardial dose of 1.5 mg/kg of encapsulated praziquantel is as effective as an intracardial dose of 30 mg/kg or an oral dose of 100 mg/kg of free praziquantel. The suppressing activity of both free and liposomes-encapsulated praziquantel significantly decrease as the infection times increase from 1 to 5 weeks, suggesting that the young liver flukes are more susceptible to praziquantel than the adult flukes.
D000818:Animals; D006224:Cricetinae; D007546:Isoquinolines / Q000627:therapeutic use*; D008081:Liposomes / Q000008:administration & dosage; D008647:Mesocricetus; D009889:Opisthorchiasis / Q000188:drug therapy*; D011223:Praziquantel / Q000627:therapeutic use*
D007546:Isoquinolines; D008081:Liposomes; D011223:Praziquantel