title: n-Butyl acrylate: cytogenetic investigations in the bone marrow of Chinese hamsters and rats after 4-day inhalation.
abstract: Chinese hamsters and rats were exposed to an average concentration of 817 ppm and 820 ppm n-butyl acrylate (acrylic acid n-butyl ester), respectively for 4 days. In both animal species, the exposure led to distinct signs of toxicity; four of ten male Chinese hamsters died during the exposure period. The chromosome analysis carried out in the bone marrow of the animals after the 4-day inhalation did not indicate any chromosome-damaging effect of n-butyl acrylate. Under the experimental conditions chosen the percentage of metaphases damaged was always in the same range as that of the controls for both Chinese hamsters and rats.
mesh_terms: D000179:Acrylates / Q000633:toxicity*; D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000179:Acrylates; C032490:n-butyl acrylate