title: Liver disease in haemophiliacs: an overstated problem?
abstract: Successful percutaneous liver biopsy was carried out on 12 multi-transfused haemophiliacs from the Manchester area with persistently abnormal liver function tests. Only one patient showed evidence of chronic active hepatitis with progression to active micronodular cirrhosis although a further four patients showed some evidence of mild chronic active hepatitis. This represents a much lower incidence of severe histological liver damage than many previous reports and implies that liver biopsy in asymptomatic haemophiliacs may not be indicated as a routine procedure, particularly in the absence of proven therapy. Dynamic liver function tests may prove to be a useful indicator of deteriorating liver function in the otherwise asymptomatic haemophiliac.
mesh_terms: D000293:Adolescent; D000328:Adult; D005690:Galactose / Q000378:metabolism; D006467:Hemophilia A / Q000150:complications* / Q000473:pathology; D006521:Hepatitis, Chronic / Q000097:blood / Q000150:complications* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D000637:Transaminases / Q000097:blood
chemical_list: D000637:Transaminases; D005690:Galactose