Phosphate and the development of nephrocalcinosis in rats fed diets containing alpha protein.
It has been suggested that nephrocalcinosis in rats fed diets containing alkali-treated soy protein may be due to a high availability of phosphate in the diet. In the present study, the development of nephrocalcinosis in rats fed a diet containing 20% alpha protein (an alkali-treated soy protein) was compared with that in rats fed the same diet supplemented with additional phosphate. Phosphate supplementation of the alpha protein diet produced a form of nephrocalcinosis that was morphologically different, at both the light- and electronmicroscopic level, from that obtained with the unsupplemented diet but was quite similar to that obtained with a phosphate-supplemented standard commercial laboratory diet. Levels of serum and urinary calcium and phosphorus and urinary cyclic AMP suggested that a phosphate-induced secondary hyperparathyroidism was present in the rats fed either of the phosphate-supplemented diets, but not in the rats fed the unsupplemented alpha protein diet. The results of this study suggest that nephrocalcinosis in rats fed a diet containing 20% alpha protein, without additional phosphate, is not typically phosphate-induced.
D000818:Animals; D001835:Body Weight; D002118:Calcium / Q000097:blood / Q000652:urine; D004044:Dietary Proteins / Q000008:administration & dosage*; D004435:Eating; D005260:Female; D005527:Food, Fortified / Q000009:adverse effects*; D007687:Kidney Tubules, Proximal / Q000648:ultrastructure; D008138:Loop of Henle / Q000648:ultrastructure; D009397:Nephrocalcinosis / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D010710:Phosphates / Q000008:administration & dosage*; D010758:Phosphorus / Q000097:blood / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D013025:Glycine max
D004044:Dietary Proteins; D010710:Phosphates; D010758:Phosphorus; D002118:Calcium