Pharmacological and toxicological studies of binodaline hydrochloride.
It has been shown, in extensive animal experiments, that 1-(omega-dimethylaminoethylmethyl)-amino-3-phenylindole hydrochloride (binodaline HCl, Sgd-Scha 1059), can be regarded as an antidepressant with novel characteristics. With anticholinergic and histamine-antagonistic effects almost completely lacking, the main effects of binodaline HCl are to increase noradrenergic influences and to produce CNS depression. The acute toxicity of binodaline HCl is comparatively low, and the good tolerance has been demonstrated in long-term studies in laboratory animals.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology* / Q000633:toxicity; D001522:Behavior, Animal / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects; D002415:Cats; D002490:Central Nervous System / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D004347:Drug Interactions; D005260:Female; D006168:Guinea Pigs; D007211:Indoles / Q000494:pharmacology* / Q000633:toxicity; D008297:Male; D051379:Mice; D008996:Monoamine Oxidase Inhibitors; D010525:Peripheral Nerves / Q000187:drug effects; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013723:Teratogens
D000928:Antidepressive Agents; D007211:Indoles; D008996:Monoamine Oxidase Inhibitors; D013723:Teratogens; C044680:binedaline