Inhibition of adenylate cyclase by a membrane protein from rat cerebrum.
The inhibitor protein of adenylate cyclase was partially purified from detergent-extract of rat brain. The inhibition occurred without lag phase. Calmodulin, GTP, guanyl 5'-yl imidodiphosphate (Gpp (NH) p) and forskolin did not change the inhibition, but activities stimulated by NaF or Mn2+ were more resistant for the inhibition. The inhibitor might include an essential sulfhydryl group.
D000067956:Adenylyl Cyclase Inhibitors; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002147:Calmodulin / Q000494:pharmacology; D005576:Colforsin; D004224:Diterpenes / Q000494:pharmacology; D006165:Guanylyl Imidodiphosphate / Q000494:pharmacology; D007700:Kinetics; D008297:Male; D008345:Manganese / Q000494:pharmacology; D008565:Membrane Proteins / Q000302:isolation & purification*; D009419:Nerve Tissue Proteins / Q000302:isolation & purification*; D051381:Rats; D011919:Rats, Inbred Strains; D012969:Sodium Fluoride / Q000494:pharmacology
D000067956:Adenylyl Cyclase Inhibitors; D002147:Calmodulin; D004224:Diterpenes; D008565:Membrane Proteins; D009419:Nerve Tissue Proteins; D005576:Colforsin; D006165:Guanylyl Imidodiphosphate; D008345:Manganese; D012969:Sodium Fluoride