title: Ethanol and dopaminergic systems.
abstract: Chronic ethanol consumption produces derangements of cell membrane structure, perhaps by changing membrane lipid content. This impairment leads to modification of membrane-related processes. In fact, after chronic ethanol exposure, an increase in striatal adenylate-cyclase activity occurs. On the other hand, dopamine is unable to further potentiate the production of cyclic AMP. This finding demonstrates that the dopaminergic receptor associated with adenylate-cyclase activity is affected by chronic ethanol treatment. In particular, the affinity of the dopaminergic receptor labelled by 3H-Spiperone is enhanced. In addition, the receptor-adenylate cyclase coupling system is impaired after chronic in vivo exposure of animals to ethanol.
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism; D000435:Alcoholic Intoxication / Q000201:enzymology; D000437:Alcoholism / Q000201:enzymology; D000818:Animals; D001921:Brain / Q000187:drug effects*; D003342:Corpus Striatum / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects*; D013570:Synaptic Membranes / Q000187:drug effects
chemical_list: D011954:Receptors, Dopamine; D000431:Ethanol; D000262:Adenylyl Cyclases; D004298:Dopamine