[Continuous intra-arterial perfusion of prostaglandin E1 in inoperable stage-IV arteriopathies].
Inoperable stage IV arteriopathies have been treated by intra-arterial PGE1 infusion since January 1978. Inoperability was established in all cases by angiography or by attempted exploration and angiography during operation. Strict criteria for therapy were applied with the result that treatment was administered to only 100 patients among 3,335 cases undergoing vascular surgery. Dosage was 0.1 to 0.2 ng of PGE1 per kilo of body weight and per minute, mean duration of treatment being 34 days. Of the 100 limb extremities probably requiring wide amputations, 47 were saved from immediate amputation, the majority of patients in whom amputation could not be avoided being diabetic. Follow-up in July 1982, 1 to 4 years after treatment, showed that 24 extremities were still intact. Best results were noted in patients with endangiitis obliterans, and long-term results no longer demonstrated differences in patients with or without diabetic arteriopathy. Intra-arterial therapy can be repeated if necessary.
D000208:Acute Disease; D000368:Aged; D000527:Alprostadil; D000671:Amputation, Surgical; D001157:Arterial Occlusive Diseases / Q000188:drug therapy*; D001162:Arteriosclerosis Obliterans / Q000150:complications / Q000188:drug therapy; D003925:Diabetic Angiopathies / Q000150:complications / Q000188:drug therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000379:methods; D008297:Male; D011458:Prostaglandins E / Q000008:administration & dosage*; D013919:Thromboangiitis Obliterans / Q000150:complications / Q000188:drug therapy; D013997:Time Factors
D011458:Prostaglandins E; D000527:Alprostadil
La perfusion intra-artérielle continue a la prostaglandine E1 (PGE1) dans les artériopathies inopérables au stade IV.