title: Muscle pyruvate oxidation following denervation and reinnervation.
abstract: Muscle pyruvate metabolism was studied in rats following sciatic nerve crush. Control studies showed high pyruvate dehydrogenase and lipoamide dehydrogenase enzyme activity in muscle with type 1 fiber predominance (soleus) and low activities in muscle with type 2 fiber predominance (extensor digitorum longus), whereas lactate dehydrogenase was much higher in the latter. Following denervation, both muscles showed a significant reduction in pyruvate dehydrogenase enzyme activity. During reinnervation, muscle with type 2 predominance developed significantly elevated pyruvate oxidation enzyme activities.
mesh_terms: D000818:Animals; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D009121:Muscle Denervation; D009132:Muscles / Q000294:innervation* / Q000378:metabolism; D009928:Organ Specificity; D010084:Oxidation-Reduction; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011768:Pyruvate Dehydrogenase Complex; D011773:Pyruvates; D007770:L-Lactate Dehydrogenase; D008058:Dihydrolipoamide Dehydrogenase