The antischistosomal activity of substituted indoles.
5-Bromoindole carboxylic acid and substituted indoles were administered parenterally to hamsters infected with an Egyptian strain of S. mansoni, to assess their antischistosomal activity. 5-Bromoindole showed a significant hepatic shift in 59 percent of treated hamsters. The results suggest that modification of the indole nucleus may produce a series of antischistosomal agents.
D000818:Animals; D006224:Cricetinae; D005260:Female; D007211:Indoles / Q000494:pharmacology*; D008099:Liver / Q000469:parasitology; D008297:Male; D008647:Mesocricetus; D012550:Schistosoma mansoni / Q000187:drug effects; D012556:Schistosomicides / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D007211:Indoles; D012556:Schistosomicides