title: [Clinical comparative trial of piretanide and furosemide in patients with advanced renal insufficiency. Drug levels and diuretic potency of single oral doses].
abstract: Piretanide is a new diuretic agent that is structurally related to bumetanide and furosemide. The effect of a single oral dose of piretanide 12 mg on the serum agent levels and diuretic activity was compared with that of Furosemide 80 mg p.o. in 12 patients with advanced renal insufficiency using a balanced randomized design. Piretanide was seen to have its most pronounced activity in the 1st h, while the effect of furosemide was more prolonged without abrupt peaks. There was a tendency of water conservation following the diuresis with piretanide, which produced a lesser response in volume and sodium excretion than furosemide when analysed as cumulative excretion at 24 h. The sodium-potassium ratio of the total urinary volume increased slightly by the same amount. Piretanide was approximately 5 times more potent on a weight basis than furosemide. Piretanide appeared to be effective in advanced renal insufficiency. Due to its rapid elimination effect piretanide as well as furosemide is also indicated for the treatment of renal edema in emergency situations.
mesh_terms: D000368:Aged; D003404:Creatinine / Q000378:metabolism; D004232:Diuretics / Q000097:blood / Q000627:therapeutic use*; D004573:Electrolytes / Q000378:metabolism; D005260:Female; D005665:Furosemide / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013449:Sulfonamides / Q000097:blood / Q000627:therapeutic use*
chemical_list: D004232:Diuretics; D004573:Electrolytes; D013449:Sulfonamides; D005665:Furosemide; D003404:Creatinine; C015451:piretanide
vernacular_title: Klinische Vergleichsprüfung von Piretanid und Furosemid bei Patienten mit fortgeschrittener Niereninsuffizienz. Wirkstoffspiegel und diuretische Potenz einer oralen Einzeldosis.