title: Influence of substrate concentration on the activation of transketolase, aspartate aminotransferase, and glutathione reductase by coenzymes.
abstract: We investigated the mechanism by which the three most commonly measured enzymes in erythrocytes are activated by their respective coenzymes by determining the catalytic activity concentrations of transketolase (EC 2.2.1.1), aspartate aminotransferase (EC 2.6.1.1), and glutathione reductase (EC 1.6.4.2) in relation to various substrate concentrations. We conclude that the underlying mechanisms by which the enzymes are activated are not the same.
mesh_terms: D001219:Aspartate Aminotransferases / Q000378:metabolism*; D003067:Coenzymes / Q000378:metabolism*; D004789:Enzyme Activation; D005980:Glutathione Reductase / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D013379:Substrate Specificity; D014174:Transketolase / Q000378:metabolism*
chemical_list: D003067:Coenzymes; D005980:Glutathione Reductase; D014174:Transketolase; D001219:Aspartate Aminotransferases