The Gunn rat: an experimental model for central deafness.
The Gunn rat which develops neonatal hyperbilirubinemia has been used as an experimental model to evaluate the effect of bilirubin on the auditory system. Electrocochleographic and morphological studies (including light microscopy, surface preparations and transmission electron microscopy) did not reveal any cochlear abnormality in homozygous Gunn rats. Brainstem auditory evoked potentials showed morphological and amplitude changes suggesting a functional damage in the brainstem auditory pathways. These results suggest that hearing loss, when observed in kernicterus, is primarily due to neuronal damage at the level of brainstem auditory nuclei.
D000818:Animals; D001933:Brain Stem / Q000503:physiopathology; D003051:Cochlea / Q000473:pathology; D004195:Disease Models, Animal; D005072:Evoked Potentials, Auditory; D006313:Hearing Loss, Central / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D006319:Hearing Loss, Sensorineural / Q000209:etiology*; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000150:complications*; D051381:Rats; D011911:Rats, Gunn; D011922:Rats, Mutant Strains