title: Inheritance of high leukocyte folate binding activity. Relationship between folate binding in leukocytes and serum.
abstract: Folate binding was determined in leukocyte lysates from relatives of three persons whose leukocytes contained large amounts of folate binding protein. A pedigree analysis showed that high leukocyte folate binding activities occurred with great frequency in these families suggesting a dominant mode of inheritance. Folate binding in serum varied within narrow limits (0.2-0.5 nmol folate/l serum) in persons with leukocyte folate binding activities less than 0.8-1.0 nmol folate per 10(9) cells. A shift to a higher level of serum folate binding (greater than or equal to 1.0 nmol/l serum) was, however, observed at leukocyte folate binding activities above that value.
mesh_terms: D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D005260:Female; D058973:Folate Receptors, GPI-Anchored; D005492:Folic Acid / Q000097:blood; D006801:Humans; D007962:Leukocytes / Q000378:metabolism*; D008297:Male; D011956:Receptors, Cell Surface
chemical_list: D002352:Carrier Proteins; D058973:Folate Receptors, GPI-Anchored; D011956:Receptors, Cell Surface; D005492:Folic Acid