Extrinsic innervation of the rat pancreas: demonstration of vagal sensory neurones in the rat by retrograde tracing.
The extrinsic innervation of the rat pancreas was examined using retrograde tracing with the fluorescent dye True Blue. Retrogradely-labelled cell bodies were seen bilaterally in the nodose ganglia, and in the spinal ganglia at levels T6-L2. Labelled cells were also seen in the dorsal motor nucleus of the vagus, the nucleus ambiguus and the coeliac ganglion. Our results provide new and direct evidence for a vagal sensory innervation of the pancreas.
D000818:Animals; D005260:Female; D005456:Fluorescent Dyes; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D009475:Neurons, Afferent / Q000502:physiology*; D010179:Pancreas / Q000294:innervation*; D051381:Rats / Q000033:anatomy & histology*; D011919:Rats, Inbred Strains; D014630:Vagus Nerve / Q000166:cytology / Q000502:physiology*
D005456:Fluorescent Dyes