title: [Effect of adjuvants on the pharmaceutical and biological availability of chlorpromazine hydrochloride].
abstract: It is reported of the influence of adjuvants upon the pharmaceutical and biological availability of chlorpromazine hydrochloride from tablets. Sodium carboxymethyl cellulose, microcrystalline cellulose (Heweten 40) and potato starch have been used for tabletting. The adjuvants added act on the pharmaceutical availability, certain differences being due to a discriminate swelling behaviour. The differences observed in vitro exert no effect on the bioavailability of the drug in the rabbit. Thus, the tablets produced with the adjuvants mentioned have proved to be preparations of almost equivalent similar biopharmaceutical behaviour.
mesh_terms: D000818:Animals; D001682:Biological Availability; D002746:Chlorpromazine / Q000008:administration & dosage / Q000378:metabolism*; D005079:Excipients; D007700:Kinetics; D011817:Rabbits; D012995:Solubility; D013607:Tablets; D013997:Time Factors
chemical_list: D005079:Excipients; D013607:Tablets; D002746:Chlorpromazine
vernacular_title: Zum Einfluss von Hilfsstoffen auf die pharmazeutische und biologische Verfügbarkeit von Chlorpromazinhydrochlorid.