Tumoricidal effects of sodium hexachloroiridate on an ascitic tumor in mice.
Sodium hexachloroiridate injected 1 day after i.p. injection of 10(6) mouse ovarian tumor cells prevents the appearance of ascitic tumors in mice. Mice given injections of tumor cells all die at 20 to 30 days after tumor injection. Mice treated with sodium hexachloroiridate after tumor injection either have significant prolongation of life span without ascites or show no evidence of cancer even up to 7 months after tumor injection.
D000818:Animals; D002945:Cisplatin / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D005260:Female; D007274:Injections, Intraperitoneal; D007495:Iridium / Q000627:therapeutic use / Q000633:toxicity*; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000473:pathology*; D014018:Tissue Distribution
C010978:hexachloroiridic acid; D007495:Iridium; D002945:Cisplatin