Screening for carcinogens by DNA-synthesis inhibition test using mouse L-cells.
Bacterial test systems for potential carcinogens sometimes give false negative results. To overcome this problem, several short term test systems have been described. One of them is the DNA-synthesis inhibition test described by Painter (1977). Our DNA-synthesis inhibition test system using mouse L-cells gave positive results when monocrothaline, phenacetin and thioacetamide, which were negative in the Ames test, were tested.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis*; D003864:Depression, Chemical; D004353:Drug Evaluation, Preclinical / Q000379:methods; D007739:L Cells / Q000378:metabolism*; D051379:Mice
D002273:Carcinogens; D004247:DNA