Dermorphin: cardiovascular and sympathetic modulation in the anteroventral hypothalamus of conscious rats.
Cardiovascular and sympathetic responses to hypothalamic injections of dermorphin were studied in conscious rats. Microinjections of 10 pmol of dermorphin into the nucleus preopticus medialis (POM) elicited tachycardia without changing the mean blood pressure (MBP). A higher dose of dermorphin (100 pmol) caused prolonged tachycardia, and an increase in MBP. The pressor/tachycardic period following injection of 100 pmol dermorphin was accompanied by increased levels of plasma norepinephrine and epinephrine. These data suggest that the POM region is an important site for sympathetic activation and pressor/tachycardic effects of dermorphin.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects*; D007032:Hypothalamus, Anterior / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009294:Narcotics / Q000494:pharmacology*; D009638:Norepinephrine / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology*; D018847:Opioid Peptides; D051381:Rats; D011919:Rats, Inbred Strains
D009294:Narcotics; D009842:Oligopeptides; D018847:Opioid Peptides; C030058:dermorphin; D009638:Norepinephrine; D004837:Epinephrine