Conditions for tracheal intubation using atracurium compared with pancuronium.
Intubating conditions were compared using atracurium 0.6 and 0.8 mg kg-1 and pancuronium 0.08 and 0.1 mg kg-1 in 96 patients. They were randomly allocated and studied at 30, 45, 60 or 75 s after injection of the drug. Smooth intubation was not possible before 60 s with either drug and in 11 patients intubation could not be achieved at the chosen time. Atracurium 0.6 mg kg-1 and pancuronium 0.08 mg kg-1 gave comparable results. Atracurium 0.8 mg kg-1 gave intubating conditions comparable to those obtained with pancuronium 0.1 mg kg-1 at 45 and 75 s and slightly better conditions at 30 and 60 s.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001279:Atracurium; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D006801:Humans; D007442:Intubation, Intratracheal; D007546:Isoquinolines / Q000494:pharmacology*; D008875:Middle Aged; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D010197:Pancuronium / Q000494:pharmacology*; D011897:Random Allocation
D007546:Isoquinolines; D009466:Neuromuscular Blocking Agents; D001279:Atracurium; D010197:Pancuronium