Evidence for 1,25-dihydroxycholecalciferol (1,25-(OH)2D3) as a proaggregating agent in rat and human platelets.
In view of the established biological role for 1,25-dihydroxycholecalciferol (DHCC) in calcium mobilization and the significance of calcium availability in platelet activation, it was of interest to investigate the potential for DHCC to act as a proaggregating agent. The present results provide evidence that DHCC at a concentration of 0.01 micrograms/microL can both aggregate human platelets and potentiate ADP-induced platelet aggregation. DHCC was also capable of aggregating rat platelets.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D002117:Calcitriol / Q000494:pharmacology*; D002118:Calcium / Q000502:physiology; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats
D000244:Adenosine Diphosphate; D002117:Calcitriol; D002118:Calcium