Fetal brain transplant: reduction of cognitive deficits in rats with frontal cortex lesions.
Frontal cortex and cerebellar tissue from fetal rats was implanted into the damaged frontal cortex of adults. Cognitive deficits in spatial alternation learning that follow bilateral destruction of medial frontal cortex were reduced in rats with frontal cortex implants but not in those with implants of cerebellum. Histological evaluation showed that connections were made between the frontal cortex implants and host brain tissue.
D000818:Animals; D001522:Behavior, Animal; D002531:Cerebellum / Q000637:transplantation*; D002540:Cerebral Cortex / Q000293:injuries / Q000637:transplantation*; D003072:Cognition Disorders / Q000503:physiopathology*; D005333:Fetus / Q000601:surgery*; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains