title: Evaluation of contingencies and conditional probabilities. A psychophysiological approach to anhedonia.
abstract: Slow brain potentials, evoked potentials and autonomic responses were investigated in anhedonic subjects and controls. The distribution of physical anhedonia (PA) scores from different samples (students, soldiers, schizophrenics, depressives) is compared. Within a S1-S2 reaction time paradigm, an additional, S2-similar stimulus was introduced during the anticipation interval in 50% of trials (pseudorandom). Subjects had to press the button only to the S2. The additional stimulus (AS) elicits a distinct positive deflection. Anhedonics show larger pre-AS negativity and less reduction in negativity after the S2 (PINV) than controls. The slow wave to S1 as well as the pre-AS negativity vary with the conditional probability of the AS, but to a lesser extent in anhedonics. Anhedonics provide more preparatory negativity prior to and following ambiguous or difficult discrimination tasks, but at the frontal site. Results may suggest impaired contingency evaluation in anhedonic subjects.
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D003265:Contingent Negative Variation; D003866:Depressive Disorder / Q000503:physiopathology; D004198:Disease Susceptibility; D004569:Electroencephalography; D005071:Evoked Potentials; D005625:Frontal Lobe / Q000503:physiopathology; D006339:Heart Rate; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000503:physiopathology*; D011930:Reaction Time / Q000502:physiology