[Renal contrast radiography study in hypertensive patients: comparison of the nephrotoxicity of ionic and non-ionic contrast media].
The results of a study carried out on 32 patients with arterial hypertension about nephrotoxic effect obtained with a new non-ionic contrast agent have been reported. The diagnostic approach was based on the determination of the urinary excretion of two characteristic enzymes of the proximal tubule-epithelial cells (alfa-glycosidase and gamma-glutamil-transferase) and of a microprotein (beta-2-microglobulin) filtered by glomeruli and readsorbed and catalized by epithelial cells. The method used show an increased sensitivity and reliability in the early recognition of a kidney damage as well as in the control of anatomic and functional changes, in comparison with the classic parameters (azotemia, creatininemia). The results show a significantly lower enzymuric and microproteinuric level using non-ionic contrast media, also, in the patients at relatively higher risk of kidney damage. This results should be interpreted in favour to a lower potential nephrotoxicity of non-ionic contrast media and their elective use in the patients with a higher risk of kidney damage.
D000328:Adult; D000368:Aged; D000792:Angiography / Q000009:adverse effects; D003287:Contrast Media / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging*; D007451:Iodamide / Q000009:adverse effects*; D007463:Iodobenzoates / Q000009:adverse effects*; D007479:Iopamidol; D007483:Iothalamic Acid / Q000009:adverse effects / Q000031:analogs & derivatives*; D007668:Kidney / Q000000981:diagnostic imaging* / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D014567:Urography / Q000009:adverse effects
D003287:Contrast Media; D007463:Iodobenzoates; D007483:Iothalamic Acid; D007451:Iodamide; D007479:Iopamidol
L'indagine contrastografica renale nel paziente iperteso: confronto della nefrotossicità tra mezzi di contrasto ionici e non ionici.