Effect of oral CDP-choline on acrylamide-induced lesion.
Administration of low doses of cytidine diphosphate choline (CDP-choline, citicoline, Somazina) (50 mg/kg) to mice and rats has proved to be effective in preventing acrylamide-induced neurological syndrome. Likewise, the simultaneous dosing of both drugs, which causes an evident loss of weight in the animals, has demonstrated that an activation on the dopaminergic system is produced.
D020106:Acrylamide; D000178:Acrylamides / Q000037:antagonists & inhibitors* / Q000633:toxicity; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D002794:Choline / Q000031:analogs & derivatives* / Q000494:pharmacology; D003566:Cytidine Diphosphate Choline / Q000494:pharmacology*; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects; D006801:Humans; D051379:Mice; D009422:Nervous System Diseases / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects
D000178:Acrylamides; D020106:Acrylamide; D003566:Cytidine Diphosphate Choline; D001058:Apomorphine; D002794:Choline