[Comparative test of the bioavailability and pharmacokinetics of 2 oxazepam preparations using high-pressure liquid chromatography].
The relative bioavailability and pharmacokinetic profile of two oxazepam preparations were evaluated in 12 normal volunteers by a newly developed HPLC-method. After oral application of one tablet of the test (Noctazepam) and reference preparation, respectively, no statistically significant differences of the AUC, Cmax Tmax and t1/2 were found. As compared to the reference preparation the relative bioavailability of the test preparation as 110%; both preparations are therefore bioequivalent.
D000328:Adult; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D010076:Oxazepam / Q000008:administration & dosage / Q000378:metabolism*; D013607:Tablets; D013997:Time Factors
D013607:Tablets; D010076:Oxazepam
Vergleichende Prüfung der Bioverfügbarkeit und Pharmakokinetik zweier Oxazepam-Präparate mit Hilfe der Hochdruckflüssigkeitschromatographie.