[Release of 14C-acetylcholine from synaptosomes as affected by presynaptic neurotoxins from bee and cobra venoms--phospholipases A2].
The effect of presynaptic neurotoxin from bee and cobra venom--phospholipases A2 on Na+-dependent high affinity [14C]choline transport from the striate body of rat brain into synaptosomes has been studied. It was shown that both phospholipases A2 inhibit the re-uptake of [14C]choline and specifically stimulate the release of [14C]acetylcholine from the synaptosomes. This effect is especially well-pronounced for bee venom phospholipase A2. It was assumed that damages of biochemical processes on the presynaptic membrane result in a blockade of synaptic transmission in nerve-muscle preparations.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001514:Bee Venoms / Q000494:pharmacology*; D002250:Carbon Radioisotopes; D003342:Corpus Striatum / Q000378:metabolism*; D004546:Elapid Venoms / Q000494:pharmacology*; D007700:Kinetics; D009498:Neurotoxins / Q000494:pharmacology*; D010740:Phospholipases / Q000494:pharmacology*; D010741:Phospholipases A / Q000494:pharmacology*; D054467:Phospholipases A2; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
D001514:Bee Venoms; D002250:Carbon Radioisotopes; D004546:Elapid Venoms; D009498:Neurotoxins; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2; D000109:Acetylcholine
Vysvobozhdenie [14C] atsetilkholina iz sinaptosom pod vliianiem presinapticheskikh neĭrotoksinov iz iadov zmei i pchely--fosfolipaz A2.