title: Histological observations on the intestinal immune response towards horseradish peroxidase in rats.
abstract: The intestine immune response in rats following immunization with horseradish peroxidase (HRP) was studied morphologically. Various routes of immunization (intraperitoneal, intravenous, intraenteric and intra-Peyer's patch) were tested. Single injections did not evoke any specific antibody-containing (anti-HRP) cells in Peyers' patches (PP) and lamina propria of the small intestine. Only an intraperitoneal or intraenteric booster injection following intraperitoneal priming induced the formation of anti-HRP cells in PP and lamina propria. In the initial period of the immune response most of the anti-HRP cells were blast cells which were located mainly within the thymus-dependent interfollicular area of PP. Later on in the immune response more than 90% of the anti-HRP cells were located in the lamina propria of the villi and had the morphology of plasma cells.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000921:Antibody-Producing Cells / Q000166:cytology; D006735:Horseradish Peroxidase / Q000276:immunology*; D007117:Immunization, Secondary; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007413:Intestinal Mucosa / Q000166:cytology / Q000276:immunology; D007421:Intestine, Small / Q000166:cytology / Q000276:immunology*; D008198:Lymph Nodes; D008297:Male; D010544:Peroxidases / Q000276:immunology*; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000276:immunology
chemical_list: D006735:Horseradish Peroxidase; D010544:Peroxidases