[Subarachnoid analgesia induced by serotonin and gamma-aminobutyric acid].
It has been shown in experiments on an isolated spinal cord of rats that morphine, serotonin and gamma-aminobutyric acid (GABA) induce the depolarization of the central terminals of primary afferents. The depolarizing effect of morphine is mediated via interneurons, while the similar effect of serotonin and GABA is the result of a direct action on primary afferents. Subarachnoidal injection of morphine (0.1-0.6 mg), serotonin (0.1-0.3 mg) and GABA (0.3-0.6 mg) provokes analgesia upon electric stimulation of the tail root in rats.
D000698:Analgesia / Q000379:methods*; D000818:Animals; D007278:Injections, Spinal; D009020:Morphine / Q000008:administration & dosage; D051381:Rats; D012701:Serotonin / Q000008:administration & dosage*; D012978:Sodium Oxybate / Q000008:administration & dosage; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage*
D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D009020:Morphine; D012978:Sodium Oxybate
Subarakhnoidal'naia anal'geziia, vyzyvaemaia serotoninom i gamma-aminomazlianoĭ kislotoĭ.