title: Residual effects of flurazepam and brotizolam on psychomotor performance.
abstract: Residual effects of brotizolam (0.25 mg) and flurazepam (30 mg) were studied in healthy young adults. Performance and subjective assessments were observed from 7 to 8 h after overnight ingestion, and effects were compared with that of placebo. Visuo-motor coordination, visuo-mental processing time, visuo-motor reaction time and reading errors were not impaired with brotizolam. There were residual effects with 30 mg flurazepam. Visuo-motor coordination, visuo-mental processing time, visuo-motor reaction time, and reading errors were impaired compared with placebo and 0.25 mg brotizolam. Subjective assessments of performance correlated with measured performance. There was a decrease with flurazepam (visuo-motor coordination and visuo-mental processing time) compared with placebo.
mesh_terms: D000328:Adult; D001381:Azepines / Q000494:pharmacology*; D005479:Flurazepam / Q000494:pharmacology*; D006801:Humans; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D008297:Male; D011597:Psychomotor Performance / Q000187:drug effects*; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
chemical_list: D001381:Azepines; D006993:Hypnotics and Sedatives; C020960:brotizolam; D005479:Flurazepam