[Plasminogen activator from a kidney cell culture].
Plasminogen activator (PA) isolated from kidney's cells culture (doses 10 to 5000 IE/kg) induced lysis of experimental thrombi. Lysis time decreased from 214 to 23 min after PA infusion in doses 10 to 700 IE/kg, further doses decrease from 700 to 5000IE/kg does not accelerate lysis time of thrombi. PA infusion in doses mentioned increases the activator activity of plasma and euglobulin lysis time, but does not change the fibrinolytic activity, antiplasmin content and fibrinogen concentration.
D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005342:Fibrinolysis / Q000187:drug effects; D005343:Fibrinolytic Agents / Q000494:pharmacology; D007668:Kidney / Q000201:enzymology*; D008297:Male; D010960:Plasminogen Activators / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D013927:Thrombosis / Q000188:drug therapy; D013997:Time Factors
D005343:Fibrinolytic Agents; D010960:Plasminogen Activators
Aktivator plazminogena iz kul'tury kletok pochki.