Identification of quinolinic acid in rat and human brain tissue.
An analytical technique for the determination of the excitotoxic compound quinolinic acid (2,3-pyridine dicarboxylic acid) in brain tissue has been developed. Following sample prepurification by ion exchange and high pressure liquid chromatography, quinolinic acid is converted to the dihexafluoroisopropyl ester and the derivative is analyzed by mass fragmentography. Using the present technique quinolinic acid has been identified in both rat and human brain tissue.
D000818:Animals; D001923:Brain Chemistry; D002851:Chromatography, High Pressure Liquid; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007474:Ion Exchange; D011725:Pyridines / Q000032:analysis*; D011805:Quinolinic Acids / Q000032:analysis*; D051381:Rats
D011725:Pyridines; D011805:Quinolinic Acids