title: Plasma levels of ethaverine after oral administration to humans.
abstract: Fourteen healthy human subjects received a 200 mg oral dose of ethaverine hydrochloride as an elixir. Blood samples were obtained for 12 h after dosing. Plasma ethaverine concentrations were determined using a paired-ion, reversed-phase high performance liquid chromatographic method. Individual plasma concentration-time profiles were fitted to a two-compartment model with first-order absorption. The ethaverine was rapidly absorbed, based on a time of maximum plasma concentration of 0.75 h, a time-lag of 8.4 min, and an apparent first-order absorption half-life of 8.6 min. The mean terminal elimination half-life was 3.3 h.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D006801:Humans; D007700:Kinetics; D008297:Male; D010208:Papaverine / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: C007639:ethaverine; D010208:Papaverine