Locomotor stimulant and intoxicant properties of methanol, ethanol, tertiary butanol and pentobarbital in Long-Sleep and Short-Sleep mice.
Methanol, ethanol, t-butanol and pentobarbital all produced marked dose dependent activation of locomotor activity in Short-Sleep mice which were selectively bred for relative insensitivity to the hypnotic properties of ethanol. The locomotor activity of alcohol sensitive Long-Sleep mice was depressed in a dose dependent fashion by all four drugs. Simultaneous assessment of intoxication in a grid test indicated that all four drugs disrupted coordination, in a dose dependent manner, to a greater degree in Long-Sleep mice than in Short-Sleep mice. The line differences in response to all alcohols was greater than for pentobarbital, indicating that the previous assumption of specificity of the selection for alcohols may be a question of degree rather than a qualitative effect.
D000435:Alcoholic Intoxication / Q000139:chemically induced* / Q000235:genetics / Q000503:physiopathology; D000438:Alcohols / Q000633:toxicity*; D000818:Animals; D000440:Butanols / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000633:toxicity; D005260:Female; D005838:Genotype; D006801:Humans; D006993:Hypnotics and Sedatives / Q000008:administration & dosage; D008297:Male; D000432:Methanol / Q000633:toxicity; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D009043:Motor Activity / Q000187:drug effects*; D010424:Pentobarbital / Q000633:toxicity*
D000438:Alcohols; D000440:Butanols; D006993:Hypnotics and Sedatives; D000431:Ethanol; D010424:Pentobarbital; D000432:Methanol