A new metabolite of butylated hydroxyanisole in man.
Butylated hydroxyanisole (I) is one of the most commonly used food antioxidants. Its use has been suggested to inhibit a variety of carcinogenic responses. The present study on the disposition kinetics of (I) in man indicates that contrary to previous reports, (I) undergoes significant O-demethylation in the body yielding a tert-butyl hydroquinone. It is suggested that this metabolic conversion may be responsible for some of the in vivo activities of (I) against chemical carcinogens.
D000840:Anisoles / Q000378:metabolism*; D001711:Biotransformation; D002083:Butylated Hydroxyanisole / Q000378:metabolism*; D002849:Chromatography, Gas; D003640:Dealkylation; D008401:Gas Chromatography-Mass Spectrometry; D005965:Glucuronates / Q000378:metabolism; D006801:Humans; D006873:Hydroquinones / Q000378:metabolism; D008297:Male; D013431:Sulfates / Q000378:metabolism
D000840:Anisoles; D005965:Glucuronates; D006873:Hydroquinones; D013431:Sulfates; D002083:Butylated Hydroxyanisole; C018855:2-tert-butylhydroquinone