Unusual sialilation of the serum DBP associated with the Gc 1 allele in alcoholic cirrhosis of the liver.
The serum level of the 'vitamin D binding protein' (DBP) or Gc ('group-specific component'), its phenotype distribution and the quantitative estimation of the different electrophoretic isoforms were determined in a sample of healthy individuals (blood donors) and in patients with alcoholic hepatitis. It is shown that the serum DBP levels and the amount of the different electrophoretic isoforms are influenced by the protein phenotypes. In the patients an increased frequency of the Gc 1 allele is noticed. For the first time, an unusual form of the apo DBP protein was detected but only in the sera of the Gc 1 allele carriers. The protein form investigated by analytical procedures presents one more sialic acid residue than the usual Gc 1 protein. This unusual metabolic transformation of the DBP is mostly observed among male patients and is often associated with a deteriorating clinical outcome.
D000328:Adult; D000368:Aged; D000483:Alleles; D002352:Carrier Proteins / Q000097:blood* / Q000235:genetics; D005260:Female; D006801:Humans; D007525:Isoelectric Focusing; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood* / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009439:Neuraminidase; D010641:Phenotype; D012794:Sialic Acids / Q000378:metabolism*; D014809:Vitamin D-Binding Protein
D002352:Carrier Proteins; D012794:Sialic Acids; D014809:Vitamin D-Binding Protein; D009439:Neuraminidase