Effect of indomethacin on rats with Grollman hypertension.
Grollman hypertension was produced in 15 Sprague-Dawley rats, and chronic 46-week hypertension was observed in these rats. Weekly subcutaneous injections of 1.44 mg indomethacin resulted in significant reduction of the systolic blood pressure 1 h after the injection (p less than 0.001). There was no change in the blood pressure following treatment with indomethacin in the 6 normotensive control rats. Light microscopic examinations revealed that adrenal and cardiac tissues were free of serious toxic indomethacin effects. Liver tissue examination showed slight degenerative changes in the indomethacin-treated animals.
D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006321:Heart / Q000187:drug effects; D006973:Hypertension / Q000188:drug therapy*; D007213:Indomethacin / Q000627:therapeutic use* / Q000633:toxicity; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D007213:Indomethacin