Studies on pokeweed mitogen-induced lymphocyte proliferation in viral hepatitis.
Lymphocyte reactivity to pokeweed mitogen (PWM) was examined in patients with acute viral hepatitis type B and in patients with chronic aggressive hepatitis etiopathogenically linked with hepatitis type B virus (HBV). The proportion of cells containing immunoglobulins in their cytoplasm was normal in PWM-stimulated lymphocyte cultures, originating from patients at an acute stage of viral hepatitis but was significantly lowered in the cases of chronic hepatitis. The findings were interpreted as a result of long term in vivo induction of lymphocyte proliferation which would restrict the in vitro reactivity of the lymphocytes to PWM.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000921:Antibody-Producing Cells / Q000276:immunology; D003593:Cytoplasm / Q000276:immunology; D006509:Hepatitis B / Q000276:immunology; D006521:Hepatitis, Chronic / Q000276:immunology; D006525:Hepatitis, Viral, Human / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D008875:Middle Aged; D011043:Pokeweed Mitogens / Q000494:pharmacology*
D011043:Pokeweed Mitogens