Influence of thymic hormones on mitogen-induced interferon production in lymphocytes. I. Augmentation of mitogen-induced immune interferon production by thymosin.
Thymosin (thymus fraction 5) in combination with concanavalin A influences both 3H-thymidine uptake in lymphocytes in vitro and the production of interferon. After in vivo pretreatment of adult mice with thymosin the mitogen-induced interferon production was about 3 times higher than in controls. The produced interferon is immune interferon (IFN gamma) as determined by rho H 2-sensitivity and lack of neutralization by mouse IFN beta-antibodies.
D000818:Animals; D002478:Cells, Cultured; D003208:Concanavalin A / Q000276:immunology; D006801:Humans; D007370:Interferon Type I / Q000032:analysis / Q000096:biosynthesis*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008806:Mice, Inbred AKR; D008934:Mitogens / Q000276:immunology*; D013154:Spleen / Q000187:drug effects / Q000276:immunology; D013947:Thymosin / Q000276:immunology*; D013951:Thymus Hormones / Q000276:immunology*
D007370:Interferon Type I; D008934:Mitogens; D013951:Thymus Hormones; D003208:Concanavalin A; D013947:Thymosin