title: Studies on phenoxy acid herbicides. II. Oral and dermal uptake and elimination in urine of MCPA in humans.
abstract: Five healthy volunteers were given 15 micrograms MCPA per kg body weight. The highest concentration in plasma, 0.15 micrograms/ml, was found after 1 h. In urine the excretion during the first 6 h was 0.46 microgram/min and 40% of given dose was excreted during the first 24 h. About 1 g of MCPA emulsion was applied on the skin of the thigh and was washed away after 2 h. Plasma level slowly increased with maximum, 0.12 micrograms/ml, after 24 h. In urine a slow excretion continued for up to 5 days later with maximum 24-48 h after application. In agricultural field exposure urinary MCPA should be estimated immediately after stop of exposure as well as 24 h after exposure. Levels under 0.5 micrograms/ml of MCPA in urine might be used as a practical biological level for good work practice. In spot samples the concentration of urine must be considered.
mesh_terms: D008456:2-Methyl-4-chlorophenoxyacetic Acid / Q000008:administration & dosage / Q000097:blood / Q000652:urine*; D000284:Administration, Oral; D000328:Adult; D005260:Female; D005542:Forearm; D006016:Glycolates / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012869:Skin Absorption; D013848:Thigh; D013997:Time Factors
chemical_list: D006016:Glycolates; D008456:2-Methyl-4-chlorophenoxyacetic Acid