[Enhancement of anti-cancer effect by potential lethal damage repair(PLDR)-inhibitors].
Nucleoside analogues (3'-dG, Ara-A) have recently been found to be an effective chemical substance for inhibiting the recovery of potential lethal damage caused by radiation and anti-cancer drugs. By combination of radiation and inhibitors, both Ara-A and 3'-dG produced a higher sensitivity effect closer to the center of "Spheroid". In the experimental tumor S-180, combination of adriamycin , cyclophosphamide and Ara-A produced an eminent sensitivity effect amounting to the enhancement ratio of 1.24 and 1.36. By combination of 5-FU and 3'-dG, an enhancement ratio of 1.39 was obtained. These findings indicate the possibility that these inhibitors may be used as a chemosensitizer and also suggest that they would be useful for chemotherapy in the future.
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000528:radiation effects; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000532:radiotherapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy*; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000532:radiotherapy; D014740:Vidarabine / Q000008:administration & dosage
D011838:Radiation-Sensitizing Agents; D004317:Doxorubicin; D003520:Cyclophosphamide; D014740:Vidarabine