Presence of mitochondrial-DNA-like sequences in the human nuclear DNA.
Two lambda phage clones carrying contiguous human nuclear DNA sequences with extensive homology to non-contiguous human mitochondrial 16S ribosomal RNA sequences were isolated from a human gene library. The one clone carried mitochondrial-DNA(mtDNA)-like sequences flanked with two kinds of repetitive nuclear DNA sequences and the other carried mtDNA-like sequences, between unique nuclear DNA sequences and repetitive DNA sequences of Alu-family. These results demonstrate that mtDNA-like sequences are present in human nuclear DNA.
D001483:Base Sequence; D002467:Cell Nucleus / Q000032:analysis*; D003001:Cloning, Molecular; D004247:DNA / Q000032:analysis*; D004272:DNA, Mitochondrial / Q000032:analysis*; D006801:Humans; D009693:Nucleic Acid Hybridization
D004272:DNA, Mitochondrial; D004247:DNA