title: [Effects of halothane and enflurane on the microcirculation].
abstract: The microcirculatory effects of halothane and enflurane were studied in a new experimental model before, during and after anaesthesia. It was only with complete volume substitution and a constant CVP during anaesthesia that blood cell velocity and capillary perfusion remained unchanged, whereas functional capillary density shifted the histogram of local pO2 to the right, i.e. towards increased pO2 values. Spontaneous arteriolar vasomotion was inhibited during anaesthesia with halothane and enflurane. The study also shows that homogeneous capillary perfusion and microcirculatory flow distribution during anaesthesia are closely related to normovolaemia and changes in CVP.
mesh_terms: D000758:Anesthesia; D000818:Animals; D002196:Capillaries / Q000187:drug effects; D006224:Cricetinae; D004737:Enflurane / Q000494:pharmacology*; D006221:Halothane / Q000494:pharmacology*; D008647:Mesocricetus; D008833:Microcirculation / Q000187:drug effects*; D010100:Oxygen / Q000097:blood; D013997:Time Factors
chemical_list: D004737:Enflurane; D010100:Oxygen; D006221:Halothane
vernacular_title: Einfluss von Halothan und Enflurane auf die Mikrozirkulation.