Oligoribonucleotide synthesis by use of nucleotide units masked with new protecting groups on the base residues of guanosine and uridine.
The synthesis of a fully protected dodecamer, GUAUCAAUAAUG, has been achieved by avoiding the side reactions on the base residues of Guo and Urd by use of the diphenylcarbamoyl and anisoyl as the protecting groups of the amide and imide functions, respectively.
D055598:Chemical Phenomena; D002621:Chemistry; D006151:Guanosine / Q000031:analogs & derivatives; D009841:Oligonucleotides / Q000138:chemical synthesis*; D009843:Oligoribonucleotides / Q000138:chemical synthesis*; D014529:Uridine / Q000031:analogs & derivatives
D009841:Oligonucleotides; D009843:Oligoribonucleotides; D006151:Guanosine; D014529:Uridine