CDP-choline: 6-month study on toxicity in dogs.
A single oral dose of 1.5 g/kg cytidine diphosphate choline (CDP-choline, citicoline, Somazina) was administered to 6 Beagle dogs daily for 6 months. After treatment period, treated animals as well as control animals were sacrificed and assessment of urinalysis, blood analysis and histopathological studies were made. Results were found within normal ranges--involving slight changes due to individual variability. It can therefore be concluded that CDP-choline does not cause any toxic effects under the chosen experimental conditions.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000633:toxicity*; D004285:Dogs; D005260:Female; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D009206:Myocardium / Q000473:pathology; D010053:Ovary / Q000473:pathology; D013154:Spleen / Q000473:pathology; D013737:Testis / Q000473:pathology
D003566:Cytidine Diphosphate Choline; D002794:Choline