Ethanol-induced chromosomal abnormalities at conception.
Preliminary findings have indicated that mouse eggs exposed briefly in vivo or in vitro to a dilute solution of ethanol activate parthenogenetically. Cytogenetic analysis of the first-cleavage chromosomes of haploid parthenogenetic embryos indicated that up to 20% of this population were aneuploid as a result of non-disjunction. Anaesthetics also can induce parthenogenesis of rodent eggs, and in studies using anaesthetics, colchicine and colcemid, abnormal chromosome segregation and heteroploidy of rodent embryos have been observed. I now report that when recently mated female mice are given a dilute solution of ethanol by mouth, non-disjunction can be induced in the female-derived, but apparently not in the male-derived, chromosome set of fertilized eggs. Taken together, these findings suggest that ethanol consumption (as well as exposure to other 'spindle-acting' agents) at the time of conception may be the cause of certain types of chromosomal defects commonly observed in human spontaneous abortions.
D000022:Abortion, Spontaneous / Q000139:chemically induced; D000782:Aneuploidy; D000818:Animals; D002869:Chromosome Aberrations; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D005306:Fertilization / Q000187:drug effects; D008297:Male; D008540:Meiosis / Q000187:drug effects; D051379:Mice; D009154:Mutation / Q000187:drug effects*; D010312:Parthenogenesis; D011247:Pregnancy
D000431:Ethanol