title: Neuroma pain model: correlation of motor behavior and body weight with autotomy in rats.
abstract: A rat pain model was investigated by examining the correlation of autotomy (self-mutilation) score with motor behavior and body weight change after sciatic nerve transection, encapsulation and neuroma formation. Observations of motor behavior and body weight changes (e.g. feeding behavior) as an index of pain were considered to have several advantages over scoring the degree of autotomy. Motor activity of 14 rats (12 neuroma, 2 sham), measured using a stabilimeter, was compared on a weekly basis to autotomy scores for a total of 7 weeks after surgery. Additionally, body weight of 26 rats (20 neuroma, 6 sham surgery) was monitored for 4 weeks following surgery. While autotomy, changes in body weight and abnormalities in motor behavior were observed after surgery, no significant Spearman rank correlation coefficients were determined for any week and thus no significant relationships were found between autotomy score and motor activity or body weight. However, it was observed that rats after sham surgery gained significantly more weight than rats after sciatic nerve transection. Therefore, these results cast doubt on the validity of autotomy score as the sole index of pain.
mesh_terms: D000818:Animals; D001835:Body Weight; D004195:Disease Models, Animal; D006801:Humans; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009374:Neoplasms, Experimental / Q000503:physiopathology; D009463:Neuroma / Q000503:physiopathology*; D010146:Pain / Q000150:complications / Q000503:physiopathology*; D051381:Rats; D012652:Self Mutilation / Q000209:etiology*; D012934:Social Isolation