[99mTc]Ca-phytate: some colloidal characteristics related to the optimal preparation conditions.
Some physico-chemical characteristics of the colloidal radiopharmaceutical [99mTc]Ca-phytate related to optimal preparation conditions have been studied. It is demonstrated that the Ca2+-phytate stoichiometry is 6:1. Two different Ca-phytate colloids seem to be formed, mainly depending on the Ca2+:phytate molar ratio--one of low mycelar size for a 1:1 Ca2+:phytate molar ratio (cmc = 5.10(-5) M), and another one, with a higher mycelar size for a 6:1 molar ratio (cmc = 8.10(-5) M). This last one it probably better for providing a good quality splenic uptake.
D003102:Colloids; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging; D012157:Mononuclear Phagocyte System / Q000000981:diagnostic imaging*; D015609:Organotechnetium Compounds; D010833:Phytic Acid / Q000138:chemical synthesis*; D011877:Radionuclide Imaging; D013154:Spleen / Q000000981:diagnostic imaging; D013667:Technetium / Q000138:chemical synthesis*
D003102:Colloids; D015609:Organotechnetium Compounds; C019099:technetium Tc 99m stannous phytate; D013667:Technetium; D010833:Phytic Acid