Demonstration of vitamin D-binding protein (Gc-globulin) in the urine of Itai-itai disease patients.
Vitamin D-binding protein (VDBP, known as Gc-globulin) was discovered by an immunochemical method in the urine of patients with Itai-itai disease. The urine and sera of Itai-itai disease patients produced specific precipitin lines with anti-human VDBP antisera. The electrophoretic mobility of the protein in the urine is the same as that in the serum. A significant correlation was found between VDBP and beta 2-microglobulin in the urine. Based on this result, it was concluded that Itai-itai disease is associated with disturbances of vitamin D transport and/or metabolism.
D000368:Aged; D000818:Animals; D002105:Cadmium Poisoning / Q000652:urine*; D002352:Carrier Proteins / Q000652:urine*; D005260:Female; D006801:Humans; D007120:Immunochemistry; D007122:Immunoelectrophoresis; D008875:Middle Aged; D011817:Rabbits / Q000276:immunology; D014809:Vitamin D-Binding Protein
D002352:Carrier Proteins; D014809:Vitamin D-Binding Protein