Specific G1-S phase cell cycle block by beryllium as demonstrated by cytofluorometric analysis.
Inhibition of cell division by beryllium (Be2+) has been examined in synchronized cultures of a liver-derived cell line (BL9L cells) using cytofluorometric cell cycle analysis. Results show that a selective dose-related block of the G1-pre-S transition is produced, with other periods of the cell cycle appearing relatively insensitive.
D000818:Animals; D001608:Beryllium / Q000494:pharmacology*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D005434:Flow Cytometry; D007399:Interphase / Q000187:drug effects*; D008099:Liver / Q000166:cytology / Q000187:drug effects; D051381:Rats
D001608:Beryllium