Changes in prostaglandin levels in the sensitized and non-sensitized uterus of the mouse after the intrauterine instillation of oil or saline.
Intrauterine instillation of oil, but not saline, induced both a decidual cell reaction and a marked elevation in the uterine PGF-alpha content of suitably sensitized ovariectomized mice. Uterine PGF-alpha concentrations were elevated within 5 min of the oil instillation, reached maximal levels within 30-60 min and then declined to near baseline levels again by 3 h. A similar increase in uterine PGF-alpha content in response to oil instillation was seen in non-sensitized females, although no decidual cell reaction developed. No significant changes in PGE or 6-oxo-PGF-1 content were observed. These results suggest that although the increase in uterine PGF-alpha content is not solely due to the distension of the uterus after intrauterine injection, the increase is not necessarily sufficient to induce a decidual cell reaction.
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000818:Animals; D002369:Castration; D003656:Decidua / Q000187:drug effects / Q000378:metabolism; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009821:Oils / Q000494:pharmacology*; D011453:Prostaglandins / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism; D011460:Prostaglandins F / Q000378:metabolism; D012965:Sodium Chloride / Q000494:pharmacology; D013997:Time Factors; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D009821:Oils; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D012965:Sodium Chloride; D015121:6-Ketoprostaglandin F1 alpha; C100006:prostaglandin F1