Importance of non-genetic mechanisms in carcinogenicity.
Integration of all this data suggests that the tumors reported by Hiraga and Fujii are related to the cytotoxicity induced in bladder epithelial tissue when primary metabolic pathways are overloaded by administration of high doses of SOPP . However, this appears to be a SECONDARY consequence of toxicity, rather than any PRIMARY effect upon DNA. Consequently, it appears that there is little chance for inducing bladder tumors with OPP or SOPP unless exposure levels are high enough to saturate primary metabolic pathways.
D000818:Animals; D001713:Biphenyl Compounds / Q000378:metabolism / Q000633:toxicity; D004247:DNA / Q000378:metabolism; D004260:DNA Repair; D004261:DNA Replication; D006801:Humans; D007700:Kinetics; D008297:Male; D008745:Methylation; D009369:Neoplasms / Q000209:etiology*; D009857:Oncogenes; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced
D001713:Biphenyl Compounds; D004247:DNA; C004369:2-phenylphenol; D010100:Oxygen