Clot lipids in ischaemic heart disease.
Total phospholipids (PL) and neutral lipid classes of plasma, of HDL and of clots produced from platelet-rich plasma and also the main coagulation parameters were determined in normal subjects and in patients with acute myocardial infarction (AMI) and with angiographically diagnosed coronary artery disease (CAD). The main plasma and HDL lipid fractions and the coagulation parameters did not differ significantly between the groups. In contrast, in both groups with ischaemic heart disease triglycerides (TG) bound to clots were selectively elevated precluding accidental trapping of lipoproteins in the fibrin network and suggesting an increased binding of TG-rich lipoproteins to clots. These changes in the quantity and quality of platelet-rich clots, resembling platelet-rich thrombi in vivo, might not only increase the volume of the clots, but also inhibit fibrinolytic enzymes from reaching their substrate. This might be significant in the pathogenesis of ischaemic heart disease.
D000328:Adult; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000032:analysis; D003327:Coronary Disease / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*; D010743:Phospholipids / Q000097:blood; D010949:Plasma / Q000032:analysis; D014280:Triglycerides / Q000097:blood
D008055:Lipids; D008075:Lipoproteins, HDL; D010743:Phospholipids; D014280:Triglycerides