[Prevention of cardiac contractile function disorders during prolonged stress by preliminary adaptation to short-term stress exposure].
Studies of contractile function of an isolated right auricle in Wistar rats have demonstrated that long-term immobilization stress (fixation in the lying position for 6 h) results in the decreased extensibility of the auricle and pronounced depression of the developed tension. Preliminary adaptation of the animals to short-term immobilization stress (daily fixation in the lying position for 1 h over 10 days) per se insignificantly affects the extensibility and contractile function of the auricle but in effect it reduces its adrenoreactivity and completely prevents the post-stressor rigidity of the auricle and its function abnormality after long-term stress.
D000222:Adaptation, Physiological; D000818:Animals; D008297:Male; D009200:Myocardial Contraction; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology*; D013997:Time Factors
Preduprezhdenie narusheniĭ sokratitel'noĭ funktsii serdtsa pri dlitel'nom stresse s pomoshch'iu predvaritel'noĭ adaptatsii k korotkim stressovym vozdeĭstviiam.