title: [Circadian changes in gastric acidity during drug therapy of duodenal ulcer].
abstract: The circadian change of gastric acidity was studied in 9 patients and 2 controls. Five patients were treated with gastrozepin, two with vicalin and buscolysin, two with biomet according to a schedule. Gastric content was aspirated at fixed intervals and pH determined separately of each portion. The data were juxtaposed to those of the gastric probe prior to the beginning of the treatment. They revealed that with the treatment with gastrozepin and biomet, the lowest pH values during the day were higher, with a statisticall significance, than those obtained at basal conditions prior to the treatment. During the night, pH over 3 was observed only in the treatment with biomet. The methodical conditions used ate suitable both for clinical-pharmacological investigations and for individualization of the treatment of some patients that failed to respond to the ordinary therapeutic combinations.
mesh_terms: D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D001570:Benzodiazepinones / Q000627:therapeutic use; D001729:Bismuth / Q000627:therapeutic use; D002086:Butylscopolammonium Bromide / Q000627:therapeutic use; D002927:Cimetidine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004381:Duodenal Ulcer / Q000178:diet therapy / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D005745:Gastric Acidity Determination; D006801:Humans; D008297:Male; D010890:Pirenzepine
chemical_list: D000897:Anti-Ulcer Agents; D001570:Benzodiazepinones; D002086:Butylscopolammonium Bromide; D010890:Pirenzepine; D002927:Cimetidine; C010804:bismuth subnitrate; D001729:Bismuth
vernacular_title: Denonoshtni izmeneniia na stomashnata kiselinnost pri medikamentoznoto lechenie na duodenalnata iazva.