Effect of selenium dioxide on the testes of rat.
Selenium dioxide was administered (ip) to albino male rats (200 +/- 5 g) in increasing doses (2, 6 and 10 micrograms/rat, daily) for 90 days. Histologic and histometric study showed that there was dose dependent injury to testes. No cellular deformation was observed following 2 micrograms-dose; whereas 6 micrograms-dose caused significant damage of gametogenic cells. At a dose of 10 micrograms, there was a significant testicular degeneration along with testicular atrophy.
D000818:Animals; D008297:Male; D051381:Rats; D012643:Selenium / Q000633:toxicity*; D018036:Selenium Compounds; D064588:Selenium Oxides; D013737:Testis / Q000187:drug effects* / Q000473:pathology
D018036:Selenium Compounds; D064588:Selenium Oxides; D012643:Selenium