Short term augmentation of amphetamine-induced rotation bias.
Using measures of stereotypy such as rearing, licking, and chewing, low dosage administration of amphetamine can be shown to produce increased stereotypy over a period of days. In the present study amphetamine-induced perservation was observed in two sessions when rotational behaviors were used as a behavioral measure. Rotational perseveration occurred in animals receiving both drug and testing experience in session one and session two. Animals receiving either drug or testing experience in session one did not show perseveration with drug and testing experience in session two.
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology*; D004292:Dominance, Cerebral / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D009434:Neural Pathways / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013239:Stereotyped Behavior / Q000187:drug effects*; D013378:Substantia Nigra / Q000187:drug effects
D003913:Dextroamphetamine