Mutator activity in Schizophyllum commune.
A strain with an elevated level of spontaneous mutations and an especially high rate of reversion at a specific locus (pab-) was identified. The mutator trait is recessive. UV sensitivity and the absence of a UV-specific endonucleolytic activity were associated with the enhancement of the mutation rate in mutator strains. The endonuclease associated with the regulation of the mutation rate also acted on single-stranded DNA. The molecular weight of this enzyme is about 38000 daltons.
D000363:Agaricales / Q000235:genetics*; D003433:Crosses, Genetic; D004277:DNA, Single-Stranded / Q000528:radiation effects; D004706:Endodeoxyribonucleases; D005808:Genes, Recessive; D007700:Kinetics; D008970:Molecular Weight; D009097:Multienzyme Complexes / Q000378:metabolism; D009154:Mutation; D009699:N-Glycosyl Hydrolases; D012567:Schizophyllum / Q000235:genetics* / Q000528:radiation effects; D013045:Species Specificity; D014466:Ultraviolet Rays
D004277:DNA, Single-Stranded; D009097:Multienzyme Complexes; C032219:UV endonuclease; D004706:Endodeoxyribonucleases; D009699:N-Glycosyl Hydrolases