Cis-diamminedichloroplatinum in the treatment of disseminated malignant melanoma.
The efficacy of cis-platinum in the treatment of recurrent advanced malignant melanoma is discussed and also the so far unpublished clinical data have been summed up. On account of the considerable differences among these data the clinical study of Stage II had been started which should contribute to the elucidation of efficacy of cis-platinum in malignant melanoma treatment. Here the first part of the trial is presented in which cis-platinum was administered to 21 patients, and the effects were studied in 17 of them. In 5 patients a partial remission was observed. These results are considered to be satisfactory enough to offer further time on the study of effects of cis-platinum.
D000328:Adult; D000368:Aged; D002945:Cisplatin / Q000009:adverse effects / Q000627:therapeutic use*; D004341:Drug Evaluation; D006801:Humans; D008545:Melanoma / Q000188:drug therapy*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012878:Skin Neoplasms / Q000188:drug therapy*
D002945:Cisplatin