Use of haplotype analysis in the beta-globin gene cluster to discover beta-thalassemia mutations.
DNA polymorphisms have been of great value in defining a small number of common sequences in the beta-globin gene cluster and a region within which recombination may be restricted. Moreover, they have led to a screening procedure that not only has been of great value for the molecular characterization of beta-thalassemia mutations but also has implications for the characterization of other single-gene disorders.
D001483:Base Sequence; D005796:Genes; D008040:Genetic Linkage; D005914:Globins / Q000235:genetics*; D006801:Humans; D009154:Mutation; D011110:Polymorphism, Genetic; D013789:Thalassemia / Q000235:genetics*
D005914:Globins