title: Clotting abnormality in lithium treated rats.
abstract: Blood clotting was markedly influenced in rats that were given lithium, either in their diet or parenterally. The clotting of whole blood was significantly enhanced in the lithium treated rats and an assessment of [prothrombin consumption index] suggests that lithium may be exerting its effect by influencing the conversion of prothrombin to thrombin. The possible clinical significance of these findings need to be assessed.
mesh_terms: D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D008094:Lithium / Q000097:blood / Q000494:pharmacology*; D051381:Rats
chemical_list: D008094:Lithium