Responsiveness of vitamin D-deficient fetal rat limb bones to parathyroid hormone in culture.
Radii and ulnae from 19-day fetal rats from normal or vitamin D-deficient mothers were treated with 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3, or parathyroid hormone in vitro. Both sets of bones resorbed in response to all three agents. Statistical analysis indicated a purely additive model for the effects of vitamin D status and the bone-resorbing agents, with no evidence for interaction. The results suggest that the impaired calcemic response to parathyroid hormone seen in vitamin D-deficient animals in vivo is not the result of a specific unresponsiveness of vitamin D-deficient bone to parathyroid hormone.
D000818:Animals; D001862:Bone Resorption / Q000187:drug effects*; D001842:Bone and Bones / Q000187:drug effects / Q000196:embryology / Q000503:physiopathology*; D002112:Calcifediol / Q000494:pharmacology; D002117:Calcitriol / Q000494:pharmacology; D002478:Cells, Cultured; D005260:Female; D005333:Fetus; D010281:Parathyroid Hormone / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D014808:Vitamin D Deficiency / Q000503:physiopathology*
D010281:Parathyroid Hormone; D002117:Calcitriol; D002112:Calcifediol