Inhibition of experimental intraocular proliferation with intravitreal 5-fluouracil.
5-Fluorouracil was used to inhibit experimental intraocular proliferation in rabbit eyes, produced by homologe fibroblast implantation. Two different concentrations were used, 1 and 5 mg in a single intravitreal injection. The eyes were followed up over 4 weeks. Proliferation and resulting traction detachment was reduced from 75% to 30% in the 1-mg 5-fluouracil group. In addition, we observed retinal and vascular changes in a considerable number of eyes treated with 1 mg and much more pronounced alterations in most of the eyes treated with 5 mg fluouracil.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects; D005472:Fluorouracil / Q000494:pharmacology*; D011817:Rabbits; D012160:Retina / Q000187:drug effects; D012171:Retinal Vessels / Q000187:drug effects; D014822:Vitreous Body / Q000166:cytology / Q000187:drug effects*
D005472:Fluorouracil