Conversion of triostins to quinomycins by protoplasts of Streptomyces echinatus.
Protoplasts of Streptomyces echinatus have been used to investigate the biosynthesis of echinomycin (quinomycin A). It has been shown that this organism has the capacity to convert a series of triostins to the corresponding quinomycins by a mechanism involving methylation. Evidence is presented which suggests that triostin A is the natural precursor of echinomycin. Conversion of tetra-N-demethyl analogues of triostin A to corresponding analogues of echinomycin was not detected.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000378:metabolism*; D002250:Carbon Radioisotopes; D004448:Echinomycin / Q000031:analogs & derivatives / Q000096:biosynthesis*; D007700:Kinetics; D011523:Protoplasts / Q000378:metabolism*; D011810:Quinoxalines / Q000096:biosynthesis* / Q000378:metabolism; D013302:Streptomyces / Q000378:metabolism*; D013462:Sulfur Radioisotopes
D000900:Anti-Bacterial Agents; D002250:Carbon Radioisotopes; D011810:Quinoxalines; D013462:Sulfur Radioisotopes; C009589:triostin C; C010777:quinomycin; C031945:triostin A; D004448:Echinomycin