Modulation of guinea-pig peritoneal macrophage Fc receptor activity using D-penicillamine.
The influence of D-penicillamine and 2,2'-pyridylisatogen tosylate upon guinea-pig peritoneal IgG Fc receptor activity is examined. D-penicillamine pretreatment of guinea-pig peritoneal cells is shown to selectively reduce the specificity of the interaction between 7s-human IgG and the guinea-pig macrophage Fc receptor population. In contrast, the drug did not influence the binding of guinea-pig 7s IgG2 nor the uptake of aggregated heterologous or homologous Immunoglobulin. Both D-penicillamine and 2,2'-pyridylisatogen tosylate are shown to influence particulate immune complex binding to pretreatment peritoneal cells.
D000818:Animals; D005260:Female; D006168:Guinea Pigs; D007074:Immunoglobulin G / Q000378:metabolism; D007136:Immunoglobulins / Q000302:isolation & purification; D066298:In Vitro Techniques; D007510:Isatin / Q000031:analogs & derivatives / Q000494:pharmacology; D007700:Kinetics; D008264:Macrophages / Q000378:metabolism*; D008297:Male; D010396:Penicillamine / Q000494:pharmacology*; D011961:Receptors, Fc / Q000187:drug effects*; D012397:Rosette Formation
D007074:Immunoglobulin G; D007136:Immunoglobulins; D011961:Receptors, Fc; C009128:2,2'-pyridylisatogen tosylate; D007510:Isatin; D010396:Penicillamine