Investigations on unspecific, intestinal elimination in the case of poisoning with psychotropic drugs.
Anticholinergic and antiserotonergic activities of the psychotropic drugs chlorpromazine, fluphenazine, imipramine and promethazine have been investigated quantitatively on the guinea-pig isolated ileum. Additional experiments were made to assure the comparability of receptor activity with human intestinal (ileum) preparations. Each of the four compounds exhibited a marked blocking potency both on muscarinic and serotonergic receptors. The antagonism was found to be slowly reversible and non-competitive in higher drug concentrations. Sodium sulfate often recommended in cases of poisoning with these drugs was nearly ineffective for evoking contractions in model investigations with drug concentrations which can be found in practical clinical conditions.
D000818:Animals; D002217:Carbachol / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007413:Intestinal Mucosa / Q000378:metabolism*; D007422:Intestines / Q000503:physiopathology; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics / Q000378:metabolism; D011619:Psychotropic Drugs / Q000378:metabolism / Q000506:poisoning*; D012702:Serotonin Antagonists / Q000378:metabolism; D013431:Sulfates / Q000494:pharmacology
D010276:Parasympatholytics; D011619:Psychotropic Drugs; D012702:Serotonin Antagonists; D013431:Sulfates; C012036:sodium sulfate; D002217:Carbachol