Differential effects of di-isopropylfluorophosphate poisoning and its treatment on opioid antinociception in the mouse.
Compounds which enhance cholinergic activity have been reported to interact with opioid drugs. We have shown, using the hot-plate test in mice that di-isopropylfluorophosphate potentiates the antinociceptive activity of alfentanil but has no effect on the activity of morphine or fentanyl. Administration of atropine and pralidoxime as a treatment for DFP poisoning does not reverse this effect, and itself potentiates morphine antinociception. The results suggest that a cholinergic/opioid interaction is dependent on the opioid studied, and may have clinical importance when opioid drugs are required in patients poisoned by irreversible anticholinesterases.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002801:Cholinesterase Reactivators / Q000494:pharmacology; D007531:Isoflurophate / Q000506:poisoning*; D008297:Male; D051379:Mice; D009294:Narcotics / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects*; D010146:Pain / Q000503:physiopathology; D011220:Pralidoxime Compounds / Q000494:pharmacology
D002801:Cholinesterase Reactivators; D009294:Narcotics; D011220:Pralidoxime Compounds; D007531:Isoflurophate; D001285:Atropine; C028797:pralidoxime