Macrophage function in high- and low-responder strains of mice.
Unstimulated peritoneal macrophages of the high-responder A/J mice compared to the low-responder B10 strain have a lower number of cells with the different Fc receptor (FcR) subtypes and correspondingly the FcR mediated phagocytosis is also lower. The intraperitoneal immunization with SRBC leads to a prompt increase of FcR expression and of phagocytic and pinocytic activity in the A/J mice, while in the B10 strain the activity of macrophages remains unchanged.
D000818:Animals; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D007114:Immunization; D007074:Immunoglobulin G; D066298:In Vitro Techniques; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D010587:Phagocytosis; D010873:Pinocytosis; D011961:Receptors, Fc / Q000276:immunology
D007074:Immunoglobulin G; D011961:Receptors, Fc