title: The control of gastric emptying.
abstract: The control of gastric emptying has been restudied. Methods used are described. It was found that in the alert unanesthetized monkey saline is emptied from the stomach at a rate that is volume-dependent; an exponential curve results since higher volumes provoke more rapid emptying and lower volumes slower emptying. For glucose test meals emptying is quite linear; also emptying is slower and progressively slower with progressive increases in glucose concentration. There is, however, an early rapid phase of gastric emptying that converts to a slower, more linear pattern. Calories rather than osmoles appear to control emptying. Glucose in the pyloris has an inhibitory effect in gastric emptying. A theory of control is discussed. The control of gastric emptying also relates to the control of feeding.
mesh_terms: D000818:Animals; D004386:Duodenum; D005746:Gastric Emptying / Q000187:drug effects; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology / Q000502:physiology; D008253:Macaca mulatta; D008297:Male; D012965:Sodium Chloride / Q000502:physiology
chemical_list: D012965:Sodium Chloride; D005947:Glucose