title: Early development of the granule cell in the cerebellum of the chick embryo.
abstract: The sequence of differentiation of the cerebellar granule cell in chick embryos from the eighth to the 15th days of incubation has been studied in Golgi-stained celloidin sections. In the germinal-cell phase, the presumptive granule cell sends out one or two horizontal processes which may originate either in the body of the cell or in the extension which attaches it to the pial surface. Thus the germinal cell may be converted into either a monopolar or a bipolar presumptive granular cell. Bipolar cells may have two processes of the same length (symmetrical cells) or of unequal length (asymmetrical cells). In the symmetrical as well as asymmetrical bipolar cells the leading process is formed, by means of which the perikaryon emigrates until it situates itself definitely in the internal granular layer. Thus, symmetrical and asymmetrical bipolar cells give rise to a granule cell with parallel fibers of equal or different lengths. The monopolar element may originate a second process or may remain in the monopolar phase until it reaches the internal granular layer. Once there, it completes the formation of the parallel fibers.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002465:Cell Movement; D002531:Cerebellum / Q000166:cytology*; D002642:Chick Embryo / Q000254:growth & development*; D006098:Granulocytes / Q000166:cytology*; D013997:Time Factors