A role for 5-hydroxytryptamine in the GABA-mimetic potentiation of alpha-flupenthixol-induced catalepsy in the rat.
1 alpha-Flupenthixol (alpha-FPT)-induced catalepsy in the rat was potentiated by diaminobutyric acid (DABA), an inhibitor of the neuronal high affinity uptake of gamma-aminobutyric acid (GABA). 2 The depletion of 5-hydroxytryptamine (5-HT) with p-chlorophenylalanine (PCPA) abolished the DABA potentiation of alpha-FPT-induced catalepsy; this response was restored with 5-hydroxytryptophan. 3 Potentiation of alpha-FPT-induced catalepsy by clonazepam was significantly reduced by methysergide. Conversely, the potentiation of catalepsy by clomipramine was significantly reduced by picrotoxin. 4 These results are interpreted as evidence supporting a role for 5-HT in modifying the GABA-ergic inhibition of dopaminergic pathways, possibly by regulating the release of GABA.
D000613:Aminobutyrates / Q000494:pharmacology; D000818:Animals; D002375:Catalepsy / Q000139:chemically induced* / Q000503:physiopathology; D002997:Clomipramine / Q000494:pharmacology; D002998:Clonazepam / Q000494:pharmacology; D005260:Female; D005475:Flupenthixol / Q000494:pharmacology*; D006801:Humans; D008784:Methysergide / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*; D013892:Thioxanthenes / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D000613:Aminobutyrates; D002997:Clomipramine; D002998:Clonazepam; D005475:Flupenthixol; D008784:Methysergide; D010852:Picrotoxin; D012701:Serotonin; D013892:Thioxanthenes; D005680:gamma-Aminobutyric Acid; C005959:2,4-diaminobutyric acid