Cerebrospinal fluid trace element content in dementia: clinical, radiologic, and pathologic correlations.
Using inductively coupled argon plasma emission spectroscopy, we measured 19 trace elements in cerebrospinal fluid of 265 patients who were undergoing diagnostic lumbar puncture. Thirty-three patients had Alzheimer-type dementia (ATD); 16 patients had other dementing illnesses; and 20 had no neurologic disease. There were seven cases of autopsy-proven Alzheimer's disease (AD) and eight autopsy controls. We found elevated CSF silicon in 24% of ATD and 71% of AD patients. We found no relationship between CSF aluminum, arsenic, lead, or manganese and ATD, AD, or other dementing illnesses.
D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000473:pathology; D003704:Dementia / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012825:Silicon / Q000134:cerebrospinal fluid; D014131:Trace Elements / Q000134:cerebrospinal fluid*; D015032:Zinc / Q000134:cerebrospinal fluid
D014131:Trace Elements; D015032:Zinc; D012825:Silicon