Excess vitamin A and the metabolism of carbohydrates: variation of enzyme activities in gingiva of rats submitted to excess vitamin A, vitamin A plus cortisol and vitamin A plus ascorbic acid.
The effect of 1 to 5 doses of 15,000 I.U. of vitamin A on some enzymes of the carbohydrate metabolism in gingival tissue from rats was studied. Vitamin A feeding resulted in a significant increase in the activities of hexokinase and pyruvate kinase with the different doses tested. A reduction in the activity of phosphofructokinase was observed with 2 and 4 doses. The administration of ascorbic acid along with vitamin A, did not prevent the effects of vitamin A on the activities of the enzymes studied. The data on the enzyme activities in the groups simultaneously fed on vitamin A and cortisol may indicate an additive effect of these compounds.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D050260:Carbohydrate Metabolism; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005881:Gingiva / Q000201:enzymology*; D006593:Hexokinase / Q000378:metabolism; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D011770:Pyruvate Kinase / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D014801:Vitamin A / Q000494:pharmacology*
D014801:Vitamin A; D006593:Hexokinase; D011770:Pyruvate Kinase; D001205:Ascorbic Acid; D006854:Hydrocortisone