Inhibition of spontaneous leukemia in F-344 rats by tetramethylthiuram disulfide (thiram).
Thiram was added at levels of 0.1 and 0.05% to the diet of F-344 rats for 2 years. The results indicated that thiram significantly reduced the incidence of spontaneous leukemia, and also tended to reduce the incidences of pituitary and thyroid tumors.
D000236:Adenoma / Q000517:prevention & control; D000238:Adenoma, Chromophobe / Q000517:prevention & control; D000818:Animals; D005260:Female; D005502:Food; D007942:Leukemia, Experimental / Q000517:prevention & control*; D008297:Male; D010911:Pituitary Neoplasms / Q000517:prevention & control; D051381:Rats; D011916:Rats, Inbred F344; D012737:Sex Factors; D013859:Thiocarbamates / Q000008:administration & dosage*; D013893:Thiram / Q000008:administration & dosage* / Q000494:pharmacology; D013964:Thyroid Neoplasms / Q000517:prevention & control
D013859:Thiocarbamates; D013893:Thiram