[The effects of gastrointestinal hormones on the growth and protein synthesis of gastric carcinomas].
The effects of gastrointestinal hormones on gastric carcinomas were examined in vitro and in vivo. In five of seventeen cases of human gastric carcinomas, the uptake of 14C-leucine into the tumor tissue in organ culture was enhanced by 10 micrograms/ml of gastrin. Also, in four of thirteen cases of human gastric carcinomas, the production of 14C-labelled proteins in medium was increased by gastrin. All the cases in which protein synthesis was enhanced by gastrin were histologically poorly differentiated adenocarcinomas. The effects of gastrin and secretin on the growth of gastric carcinoma, which was serially transplanted in athymic mice, were examined. The doubling time of the tumor was 7.1 days. The doubling time was shortened to 4.1 days by daily administration of 250 micrograms/kg of gastrin. This topic effect of gastrin on gastric carcinoma was inhibited by 100 U/kg of secretin. These results showed that the growth and protein synthesis of gastrointestinal tumor may be regulated by gastrointestinal hormones.
D000230:Adenocarcinoma / Q000378:metabolism / Q000473:pathology; D000818:Animals; D002277:Carcinoma / Q000378:metabolism / Q000473:pathology; D002455:Cell Division / Q000187:drug effects; D005755:Gastrins / Q000494:pharmacology*; D006801:Humans; D007930:Leucine / Q000378:metabolism; D051379:Mice; D008819:Mice, Nude; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009368:Neoplasm Transplantation; D012633:Secretin / Q000494:pharmacology*; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology
D005755:Gastrins; D009363:Neoplasm Proteins; D012633:Secretin; D007930:Leucine