Comparative study on the cytostatic effects and the tissue distribution of 5-fluorouracil in a free form and bound to polybutylcyanoacrylate nanoparticles in sarcoma 180-bearing mice.
The binding of 5-fluorouracil to polybutylcyanoacrylate nanoparticles yielded an enhanced efficacy against Crocker sarcoma S 180 and a higher toxicity of the drug measured by induced leukopenia, body weight loss and premature death. The efficacy was further increased by an increase in the polymer-to-drug ratio. The nanoparticles yielded a prolonged persistence of the 5-fluorouracil in all organs examined including the tumor. These particles hold promise as carriers for cytostatics, since their distribution may be favorably altered by coating them with certain proteins or surfactants or by the attachment of monoclonal antibodies.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004659:Enbucrilate / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D005472:Fluorouracil / Q000378:metabolism / Q000627:therapeutic use* / Q000633:toxicity; D007970:Leukopenia / Q000139:chemically induced; D051379:Mice; D014677:Pharmaceutical Vehicles; D012510:Sarcoma 180 / Q000188:drug therapy*; D014018:Tissue Distribution
D014677:Pharmaceutical Vehicles; D004659:Enbucrilate; D005472:Fluorouracil