The metabolism of ethylbenzene hydroperoxide in the rat.
Ethyl[14C]benzene hydroperoxide administered orally to female rats (30 mg/kg) is rapidly absorbed and metabolized. Most of the administered compound (81%) is eliminated in the 0-24 h urine. Major metabolites include mandelic acid (23%), hippuric acid (34%) and 1-phenylethyl glucuronide (4%). Ethyl[14C]benzene is metabolized via 1-phenylethanol to the same mixture of metabolites as obtained with the hydroperoxide. Biotransformations of the hydroperoxide and their likely biochemical mechanisms are discussed.
D000818:Animals; D001345:Autoradiography; D001711:Biotransformation; D002250:Carbon Radioisotopes; D002855:Chromatography, Thin Layer; D005260:Female; D008658:Inactivation, Metabolic; D010545:Peroxides / Q000378:metabolism* / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D002250:Carbon Radioisotopes; D010545:Peroxides; C041000:ethylbenzene hydroperoxide