title: The 20/20 eye in multiple sclerosis.
abstract: Using clinical and electrophysiologic measures, we evaluated the visual pathway of patients who had multiple sclerosis, 20/20 Snellen acuity, and no history of optic neuritis. Delayed latencies were found in the transient visual evoked potentials (VEPs) of 38% of the patients, and interocular latency differences were abnormal in 67%. Contrast VEPs were abnormal in 46%. Psychophysical determinations of contrast sensitivity were abnormal in 78%. Only 17% of the patients had dyschromatopsia, 36% had afferent pupillary abnormalities, and 59% had optic nerve pallor or nerve fiber layer loss. Psychophysical contrast evaluations and VEP studies were superior to other clinical evaluations in demonstrating visual dysfunction in these patients.
mesh_terms: D005074:Evoked Potentials, Visual; D006801:Humans; D009103:Multiple Sclerosis / Q000150:complications / Q000503:physiopathology*; D014786:Vision Disorders / Q000150:complications / Q000503:physiopathology*; D014792:Visual Acuity; D014795:Visual Pathways / Q000502:physiology; D014796:Visual Perception / Q000502:physiology