Pharmacokinetics of catalytically tritiated glycosaminoglycans in the rat.
Glycosaminoglycan mixture catalytically labelled with tritium gas (3H-GAG) was shown to have chemical characteristics and antithrombin-heparin cofactor activity in vitro similar to those of the native mixture of glycosaminoglycans (GAG). Rats were orally dosed with 3H-GAG in either aqueous solution or vegetable oil emulsion and the quantity of radioisotope absorbed assessed at various intervals. The quantity of 3H in plasma plateaued 8 h after dosing and remained near peak levels at least 16 h. Time dependent accumulation of the radioisotope within liver, spleen and testes was also observed.
D000818:Animals; D002384:Catalysis; D006025:Glycosaminoglycans / Q000378:metabolism*; D066298:In Vitro Techniques; D007553:Isotope Labeling / Q000379:methods; D007700:Kinetics; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013552:Swine; D014316:Tritium
D006025:Glycosaminoglycans; D014316:Tritium