Potentiation of the antitumor effect of 5-fluorouracil by some nucleotides, and their possible role in the potentiation.
Of the various nucleotides tested, adenosine 5'-triphosphate (ATP), guanosine 5'-triphosphate, inosine 5'-triphosphate, and adenosine 5'-monophosphate potentiated the antitumor activity of 5-fluorouracil against Ehrlich carcinoma, while uridine 5'-triphosphate, cytidine 5'-triphosphate, deoxyadenosine 5'-triphosphate, and deoxyguanosine 5'-triphosphate were ineffective. The result of biochemical experiments suggests that ATP, which was used as a representative of the effective nucleotides, was ineffective until it was hydrolyzed to adenosine by nucleotide phosphohydrolases in the ascitic fluid of mice bearing Ehrlich ascites tumor cells, and that the adenosine functioned as a ribose donor for the increased formation of antineoplastic 5-fluoronucleotides. The possible role of the various effective nucleotides and nucleosides was discussed.
D000241:Adenosine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D004357:Drug Synergism; D005472:Fluorouracil / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D009711:Nucleotides / Q000494:pharmacology*
D009711:Nucleotides; D000255:Adenosine Triphosphate; D000241:Adenosine; D005472:Fluorouracil