title: Inhibition of cysteamine-induced duodenal ulcer in the rat by bile diversion. Enhancement of the ulcerogenic effect of cysteamine by taurocholic and glycocholic acids.
abstract: Three groups of rats were twice given cysteamine subcutaneously in a dose of 20 mg/100 g body weight. Nine of 10 controls developed severe duodenal ulcers. In contrast, the ulcer formation was inhibited significantly in the rats submitted, before exposure to cysteamine, to a bile diversion operation consisting of jejunopylorostomy and Roux-en-Y anastomosis without gastric resection. However, rats submitted to the same operation but drinking a solution with 5 mmol/l sodium salts of taurocholic and glycocholic acid, 1:3, developed severe duodenal ulcers after cysteamine injections (8 of 10). The conclusion is that neither the chemical cysteamine nor hydrochloric acid alone can be made responsible for cysteamine-induced duodenal ulcer in the rat, but that bile salts clearly enhance the ulcerogenic property of cysteamine.
mesh_terms: D000818:Animals; D001646:Bile / Q000502:physiology*; D003543:Cysteamine / Q000008:administration & dosage; D004381:Duodenal Ulcer / Q000139:chemically induced*; D006000:Glycocholic Acid / Q000008:administration & dosage / Q000502:physiology*; D007583:Jejunum / Q000502:physiology; D008297:Male; D011706:Pyloric Antrum / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013656:Taurocholic Acid / Q000008:administration & dosage / Q000502:physiology*
chemical_list: D013656:Taurocholic Acid; D003543:Cysteamine; D006000:Glycocholic Acid