[Role of the amygdala in the sedation induced by low doses of apomorphine].
In the present study the role of amygdala in the antidepressant action of imipramine is discussed. An animal model of depression is induced, in rats, by systemic injection of low doses of apomorphine. Systemic administration of imipramine prevents, as already reported, apomorphine-induced sedation. The same effect is observed following intra-amygdaloid imipramine administration. On the contrary, local injection of imipramine in frontal cortex or caudate nucleus does not affect apomorphine-induced sedation.
D000679:Amygdala / Q000502:physiology*; D000818:Animals; D001058:Apomorphine; D003863:Depression / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D007099:Imipramine / Q000627:therapeutic use; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D001058:Apomorphine; D007099:Imipramine
Ruolo dell'amigdala nella sedazione indotta da basse dosi di apomorfina.