Long term treatment with tienilic acid or thiazides: comparison of antihypertensive and metabolic effects.
A comparison has been made of arterial pressure and major metabolic parameters during long term treatment with tienilic acid and a hydrochlorothiazide-amiloride combination, using a randomized single-blind study without cross-over. A significant fall in systolic and diastolic blood pressure and no change in most biochemical parameters was observed with both drugs. Serum uric acid concentration was decreased during tienilic acid and was slightly increased whilst subjects took the hydrochlorothiazide-amiloride combination; serum potassium was slightly decreased on tienilic acid. No sign of hepatotoxicity was detected.
D000328:Adult; D000584:Amiloride / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006016:Glycolates / Q000627:therapeutic use*; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D011719:Pyrazines / Q000627:therapeutic use*; D011897:Random Allocation; D013989:Ticrynafen / Q000627:therapeutic use*; D014527:Uric Acid / Q000097:blood
D006016:Glycolates; D011719:Pyrazines; D006852:Hydrochlorothiazide; D014527:Uric Acid; D000584:Amiloride; D013989:Ticrynafen; D011188:Potassium