Radiation nephritis in a case of a spindle cell neoplasm in remission after combination treatment with abdominal radiotherapy and chemotherapy.
A 34-year-old woman presented with acute radiation nephritis three months after completion of treatment with cytotoxic chemotherapy and abdominal radiotherapy. This case and similar previous reports suggest a potentiating effect by the chemotherapy of the renal damage by radiation which may cause radiation nephritis to develop at radiation doses normally within renal tolerance.
D000008:Abdominal Neoplasms / Q000628:therapy*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols; D003520:Cyclophosphamide / Q000009:adverse effects; D004317:Doxorubicin / Q000009:adverse effects; D005260:Female; D006801:Humans; D009393:Nephritis / Q000209:etiology*; D011241:Prednisone / Q000009:adverse effects; D011878:Radiotherapy / Q000009:adverse effects*; D012509:Sarcoma / Q000628:therapy*; D014750:Vincristine / Q000009:adverse effects
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone