Immunohistochemical study of substance P-like immunoreactivity in human thyroid and medullary carcinoma of the thyroid.
Substance P-like immunoreactivity (SPL-IR) was identified by the indirect peroxidase anti-peroxidase (PAP) method in normal thyroid glands as well as in medullary thyroid carcinoma. The SPL-IR cells were visualized intrafollicularly in the thyroid, within cells which resembled the parafollicular C cells which contain calcitonin immunoreactivity. The SPL-IR cells distributed differently in the normal thyroid and in thyroid with secondary C cell hyperplasia.
D002116:Calcitonin / Q000032:analysis; D002277:Carcinoma / Q000032:analysis* / Q000556:secondary; D006111:Graves Disease / Q000378:metabolism; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008113:Liver Neoplasms; D008207:Lymphatic Metastasis; D010455:Peptides / Q000032:analysis*; D013961:Thyroid Gland / Q000032:analysis*; D013964:Thyroid Neoplasms / Q000032:analysis* / Q000556:secondary
D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; C016116:substance P-like peptides; D002116:Calcitonin