[Amanita virosa peptides: viroidin and viroisin are more effective than phalloidin for the in vitro protection of actin against the effects of osmic acid].
Virotoxins are a group of monocyclic peptides recently identified in the deadly mushroom Amanita virosa by Faulstich and coll. We found that two of these peptides, which have a methyl sulfonyl group, namely viroidin and viroisin are very effective to protect F-actin against oxidative degradation by osmium tetroxide in vitro. Their desoxo analogs, which have a methyl sulfoxyde group instead of methyl sulfonyl are less active, therefore there exists a relationship between the chemistry of the sulfur group and the activity of the peptides.
D000199:Actins; D000363:Agaricales / Q000032:analysis*; D000545:Amanita / Q000032:analysis*; D000818:Animals; D066298:In Vitro Techniques; D009992:Osmium / Q000494:pharmacology*; D009993:Osmium Tetroxide / Q000494:pharmacology*; D010456:Peptides, Cyclic / Q000494:pharmacology*; D010590:Phalloidine / Q000494:pharmacology; D011817:Rabbits
D000199:Actins; D010456:Peptides, Cyclic; D010590:Phalloidine; D009992:Osmium; C040702:viroidin; C040703:viroisin; D009993:Osmium Tetroxide
Des peptides de Amanita virosa: viroidine et viroisine sont plus efficaces que la phalloidine pour protéger l'actine in vitro contre les effets de l'acide osmique.