Effect of estradiol dipropionate on uterine and vaginal glycogen content of Parkes (P) mice.
Administration of estradiol dipropionate (20 micrograms/day: for 7 days) to ovariectomized (7 days) mice produced about three fold increase (180%) in uterine glycogen content while approximately four fold decrease (76%) in vaginal glycogen as compared to their control values. Differences in glycogen content after 7 and 14 days of ovariectomy were statistically insignificant in both the organs. Although estradiol dipropionate had a great effect on the glycogen content of uterus and vagina but this effect remained more or less unchanged after causing alteration in duration (7 and 14 days) of estradiol dipropionate treatment in relation to different time intervals (7 and 14 days) after ovariectomy. So there was no time dependent response in uterine and vaginal glycogen content after 7 days onwards either in relation to ovariectomy or estradiol dipropionate treatment. The opposite trend (increase in uterus and decrease in vagina) of glycogen content in response to estradiol dipropionate may be possibly due to a greater accumulation (than utilization) in uterus while greater consumption (than accumulation) in vagina.
D000818:Animals; D002369:Castration; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D006003:Glycogen / Q000378:metabolism*; D051379:Mice; D010053:Ovary / Q000502:physiology*; D014599:Uterus / Q000187:drug effects* / Q000378:metabolism; D014621:Vagina / Q000187:drug effects* / Q000378:metabolism
D004958:Estradiol; D006003:Glycogen; C023482:estradiol dipropionate