[Effect of tuftsin on enzyme activity in the energy metabolism of lymphocytes].
The cytochemical technique was used to measure the activity of succinate dehydrogenase (SDH), lactate dehydrogenase (LDH) and glucose-6-phosphate dehydrogenase (G-6-PDH) of peripheral blood lymphocytes of mice and rats given intraperitoneal injections of an endogenous immunostimulant tuftcin (Tre-Lys-Pro-Arg) in a dose of 0.3 mg/kg. A significant decrease of SDH activity was observed both in mice and rats 4 and 6 hours following injection, respectively. In mice, that activity returned to normal in 12, while in rats in 24 hours. An opposite action was produced by tuftcin on G-6-PDH, causing the maximum elevation of the enzyme activity in rat lymphocytes 6 hours after peptide administration. The decrease to the initial level was observed in 24 hours. Tuftcin did not affect the activity of LDH. The data obtained indicate that the immunological effect of tuftcin is coupled with the changes in the activity of Krebs cycle enzymes (SDH) and pentose phosphate cycle enzymes (G-6-PDH).
D000818:Animals; D003864:Depression, Chemical; D004734:Energy Metabolism; D005954:Glucosephosphate Dehydrogenase / Q000097:blood*; D007128:Immunoglobulin Fragments / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008214:Lymphocytes / Q000201:enzymology*; D008297:Male; D051379:Mice; D051381:Rats; D013268:Stimulation, Chemical; D013385:Succinate Dehydrogenase / Q000097:blood*; D014405:Tuftsin / Q000494:pharmacology*
D007128:Immunoglobulin Fragments; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D014405:Tuftsin
Vliianie taftsina na aktivnost' nekotorykh fermentov énergeticheskogo metabolizma limfotsitov.