Hydroxylation of secondary bile acids in the perfused prairie dog liver.
Taurolithocholic acid and deoxycholic acid were perfused into isolated prairie dog livers. Taurolithocholic acid was 7 alpha-hydroxylated to form taurochenodeoxycholic acid, whereas deoxycholic acid was conjugated and 7 alpha-hydroxylated to form taurocholic acid. The low concentrations of secondary bile acids observed in prairie dog bile are due, at least in part, to active bile acid 7 alpha-hydroxylase(s) in the liver of these animals.
D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D003840:Deoxycholic Acid / Q000378:metabolism; D005260:Female; D006900:Hydroxylation; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D008297:Male; D010477:Perfusion; D012377:Rodentia / Q000378:metabolism*; D013658:Taurolithocholic Acid / Q000378:metabolism
D001647:Bile Acids and Salts; D003840:Deoxycholic Acid; D013658:Taurolithocholic Acid