Localisation of the human N-ras oncogene to chromosome 1cen - p21 by in situ hybridisation.
The N-ras gene is a transforming gene isolated from a variety of human tumour cell lines and is a member of a family of related ras genes. Somatic cell hybrids have previously shown that the N-ras gene is located on chromosome 1. We have confirmed this localisation by in situ hybridisation to metaphase preparations of lymphocytes and localised the gene to the region 1cen - p21. A survey has found 47 reported cases of malignancy involving deletions in the short arm of chromosome 1. Fifteen of the 47 involved a deletion in this region.
D002874:Chromosome Mapping; D002900:Chromosomes, Human, 1-3; D006801:Humans; D008214:Lymphocytes / Q000502:physiology; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D014176:Protein Biosynthesis