Different patterns of uremic polyneuropathy: clinicopathologic study.
Ten patients with a uremic polyneuropathy were investigated. Chronic renal failure was associated with a variety of neuropathies, including an acute axonal neuropathy, a progressive axonal neuropathy with secondary segmental demyelination, and a predominantly demyelinative neuropathy. All patterns were associated with distal degeneration of fibers evidenced by axonal sprouting observed on single-fiber preparations. The etiology of such variations in pathology of uremic neuropathy is still not clearly understood.
D000293:Adolescent; D000328:Adult; D001369:Axons / Q000648:ultrastructure; D001706:Biopsy; D005260:Female; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D009412:Nerve Fibers / Q000473:pathology; D009413:Nerve Fibers, Myelinated / Q000473:pathology; D009422:Nervous System Diseases / Q000209:etiology* / Q000473:pathology; D013497:Sural Nerve / Q000473:pathology / Q000648:ultrastructure; D014511:Uremia / Q000150:complications*