Effects of propantheline bromide on basal growth hormone, cortisol and prolactin levels.
Propantheline bromide, a peripheral anticholinergic drug with muscarinic and nicotinic blocking properties, was given by mouth to normal young men. Propantheline (45 mg) significantly lowered basal growth hormone concentrations at 0800 hr, 12 hr after administration. Propantheline (30 mg) tended (p = 0.08) to lower growth hormone concentrations at 1200 hr, 16 hr after administration. Cortisol and prolactin levels were not changed 12, 16 and 20 hr after propantheline (30 mg) nor 12 hr after propantheline (45 mg).
D000328:Adult; D001812:Blood-Brain Barrier; D002940:Circadian Rhythm; D004305:Dose-Response Relationship, Drug; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism*; D008297:Male; D011388:Prolactin / Q000378:metabolism*; D011413:Propantheline / Q000494:pharmacology*; D011950:Receptors, Cholinergic / Q000187:drug effects
D011950:Receptors, Cholinergic; D011413:Propantheline; D011388:Prolactin; D013006:Growth Hormone; D006854:Hydrocortisone