Characterization of impurities in commercial lots of sodium saccharin produced by the Sherwin-Williams process. II. Mutagenicity.
The mutagenic activity of solvent extracts of specific manufacturing lots of saccharin produced by the Sherwin-Williams process was studied in detail. All the individual components identified were found to be non-mutagenic. The mutagenic activity of saccharin lot S-1469 was traced to a moderately polar chromatographic fraction representing impurities present in the saccharin at a level of less than 1.5 ppm, but was not attributable to a single component. In view of the low level of mutagenic activity observed and the low concentration of total impurities in Sherwin-Williams saccharin, the mutagenic material(s) are probably of no significance in animal feeding studies.
D004340:Drug Contamination; D009153:Mutagens / Q000302:isolation & purification*; D012439:Saccharin / Q000032:analysis / Q000138:chemical synthesis / Q000633:toxicity*; D012997:Solvents
D009153:Mutagens; D012997:Solvents; D012439:Saccharin