[Human and mouse somatic cell hybrids with different parental genome ratios].
Some properties of four hybrids between continuous mouse cells Rag and human diploid embryonal fibroblasts were described. During initial four months after fusion, hybrid cells with the parental genome ratio 1 mouse (m) - 1 human (h) were displaced by cells with the ratio 2m - 1h and 3m - 1h. Further passages lead to selection of cells with 10-12 human chromosomes and two and three chromosome sets of Rag cells.
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D004171:Diploidy; D005347:Fibroblasts / Q000648:ultrastructure; D005796:Genes; D006801:Humans; D006822:Hybrid Cells / Q000648:ultrastructure*; D007680:Kidney Neoplasms / Q000235:genetics; D008677:Metaphase; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000235:genetics
Gibridy somaticheskikh kletok cheloveka i myshi s raznymi sootnosheniiami roditel'skikh genomov.