The effect of cigarette smoke on aryl-hydrocarbon hydroxylase (AHH) activity of the human kidney.
AHH activity was measured in kidney cortex biopsies obtained during surgery from patients with hydronephrosis and from unaffected portions of kidneys with renal cell carcinomas. AHH activity was slightly, but not significantly, higher in the group of non-smoking cancer patients when compared to non-smoking hydronephrotic subjects. Smoking induced a significant increase of AHH activity in the hydronephrotic kidneys but not in cancer kidneys, probably due to the higher baseline values and scatter in the cancer group. Pooling cancer and non-cancer kidneys, smokers had a higher AHH activity than non-smokers, this increase being dose-related.
D000230:Adenocarcinoma / Q000201:enzymology; D000293:Adolescent; D000328:Adult; D000368:Aged; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D005260:Female; D006801:Humans; D006869:Hydronephrosis / Q000201:enzymology; D007672:Kidney Cortex / Q000201:enzymology*; D007680:Kidney Neoplasms / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D012907:Smoking
D001189:Aryl Hydrocarbon Hydroxylases