[Possibility of influencing drug release from polymers--using the example of bead polymers].
By the example of the model drug phenobarbital, the authors report of the possibilities of influencing the liberation of drugs from acrylate-based bead polymers. The drug-containing bead polymers produced were studied in vitro (half-change method, beaker device according to Moldenhauer, artificial digestive juices according to Münzel, without addition of enzymes). The composition of a unit-dose preparation, composed of several batches prepared under different conditions, is dealt with. The release values obtained largely meet the requirements made on depot preparations.
D000180:Acrylic Resins; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D010634:Phenobarbital / Q000008:administration & dosage; D011108:Polymers; D012995:Solubility; D013997:Time Factors
D000180:Acrylic Resins; D003692:Delayed-Action Preparations; D011108:Polymers; D010634:Phenobarbital
Möglichkeiten der Beeinflussung des Liberationsverhaltens von Arzneistoffen aus Polymeren-dargestellt am Beispiel von Perlpolymerisaten.