Association between centriole and nuclear matrix in human lymphocytes.
Nuclear matrices, purified from normal and chronic lymphocytic leukemia lymphocytes, exhibit a close association with the centriole. This finding suggests that the nuclear and cytoplasmic skeletal systems are linked by transmembrane connections represented by nuclear matrix constituents. This could account for the observed synchrony between transformations of the centriole and particular nuclear events which take place during the cell cycle and suggests that the nuclear matrix, besides being involved in DNA replication and chromosome condensation, should affect the centriole cycle which controls the cytoskeleton organization.
D002455:Cell Division; D002467:Cell Nucleus / Q000648:ultrastructure*; D002502:Centrioles / Q000648:ultrastructure*; D003599:Cytoskeleton / Q000648:ultrastructure; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure*; D009940:Organoids / Q000648:ultrastructure*