title: The time course of protection from delayed neurotoxicity induced by tri-o-cresyl phosphate and O,O-diisopropyl phosphorofluoridate by phenyl methyl sulfonyl fluoride in chickens.
abstract: The time dependence of the ability of phenyl methyl sulfonyl fluoride (PMSF) to protect adult hens from developing signs of paralysis following the administration of 750 mg/kg tri-ortho-cresyl phosphate (TOCP), p.o., of 1.7 mg/kg O,O-diisopropyl phosphorofluoridate (DFP), s.c., was investigated. PMSF was able to protect the hens from organophosphorus-induced delayed neurotoxicity (OPIDN) when given between 1 and 24 h before the administration of TOCP, or when given 4 h before DFP. However, PMSF was ineffective at preventing paralysis when given 24 h following dosing with TOCP or when given later than 4 h before DFP administration. These results support the notion that PMSF acts at the same site as the organophosphorus esters.
mesh_terms: D000818:Animals; D002645:Chickens; D003408:Cresols / Q000633:toxicity*; D004347:Drug Interactions; D007531:Isoflurophate / Q000633:toxicity*; D010243:Paralysis / Q000139:chemically induced*; D010664:Phenylmethylsulfonyl Fluoride / Q000494:pharmacology*; D010968:Plasticizers / Q000633:toxicity*; D013450:Sulfones / Q000494:pharmacology*; D013997:Time Factors; D014317:Tritolyl Phosphates / Q000633:toxicity*
chemical_list: D003408:Cresols; D010968:Plasticizers; D013450:Sulfones; D014317:Tritolyl Phosphates; D007531:Isoflurophate; D010664:Phenylmethylsulfonyl Fluoride; C025541:tri-o-cresyl phosphate