Erythropoietin production by a human testicular germ cell line.
An established human testis germ cell line (1411-H) was found to produce significant amounts of erythropoietin (Ep), the primary regulator of erythropoiesis. Media conditioned by the 1411-H cells stimulated erythropoiesis both in vivo and in vitro. This activity was neutralized by anti-Ep. This continuous cell line provides a unique model for the study of the mechanisms of control of Ep biogenesis.
D002460:Cell Line; D002470:Cell Survival; D004912:Erythrocytes / Q000378:metabolism; D004921:Erythropoietin / Q000096:biosynthesis*; D006801:Humans; D000860:Hypoxia / Q000097:blood; D066298:In Vitro Techniques; D007504:Iron Radioisotopes; D008297:Male; D013737:Testis
D007504:Iron Radioisotopes; D004921:Erythropoietin