Alterations of erythrocyte lipid pattern and of some membrane related functions as a consequence of plasma lipid disorder in diabetes mellitus.
The influence of plasma lipid disorders on red blood cell (RBC) lipid pattern and some related erythrocyte membrane functions, such as glycerol (GLT50) permeability and erythrocyte deformability was studied in diabetes mellitus. Significantly higher red blood cell cholesterol content, GLT50 and erythrocyte filtration time values were found in diabetics. GLT50 values were found closely related to both RBC cholesterol content (r = 0.84, p less than 0.001) and filtration time (r = 0.60, p less than 0.001). Interestingly, six diabetics with retinopathy showed GLT50 values above 60 sec. The RBC Cholesterol/Phospholipids molar ratio was significantly higher in diabetics. The most notable changes of plasma lipid pattern in diabetics were a decrease of both plasma HDL cholesterol, phospholipids and Apolipoprotein A levels with an increase of HDL free cholesterol/phospholipids molar ratio. RBC cholesterol content was found to be inversely related to HDL esterified/free cholesterol molar ratio (r = -0.56, p less than 0.001), while RBC cholesterol/phospholipids molar ratio was significantly related to both HDL free cholesterol/phospholipids (r = 0.51, p. 0.001) and to LDL total cholesterol/phospholipids (r = 0.25, p less than 0.05). Lastly, HDL cholesterol levels were found to inversely relate to glycosylated haemoglobin values (r = -0.54, p less than 0.01).
D000328:Adult; D001053:Apolipoproteins / Q000097:blood; D001054:Apolipoproteins A; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004910:Erythrocyte Membrane / Q000502:physiology*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D005990:Glycerol / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood; D014462:Ultrafiltration
D001053:Apolipoproteins; D001054:Apolipoproteins A; D008076:Cholesterol, HDL; D008055:Lipids; D008075:Lipoproteins, HDL; D010743:Phospholipids; D002784:Cholesterol; D005990:Glycerol