Influence of single doses of dothiepin and amitriptyline on physiological measures and psychomotor performance in normal young and elderly volunteers.
The subjects were 14 (7 young and 7 elderly) men. Self-rating, and physiological and psychological measurements were applied, and experiments were performed 24 h after drug administrations. 25 mg dothiepin hydrochloride (DP) decreased critical flicker frequency less than 25 mg AMP in both age groups. 25 mg DP reduced whole mouth salivary rates less than 25 mg AMP, especially in the young subjects. 25 mg DP decreased diastolic blood pressure more than 25 mg AMP. Systolic blood pressure (after 25 mg DP and 25 mg AMP) and whole mouth salivary rates (after 25 mg AMP) were affected more intensely in the elderly than in the young volunteers.
D000328:Adult; D000368:Aged; D000639:Amitriptyline / Q000009:adverse effects*; D001143:Arousal / Q000187:drug effects*; D001288:Attention / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D003988:Dibenzothiepins / Q000009:adverse effects*; D004308:Dothiepin / Q000009:adverse effects*; D004311:Double-Blind Method; D005425:Flicker Fusion / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D011597:Psychomotor Performance / Q000187:drug effects*; D012472:Salivation / Q000187:drug effects
D003988:Dibenzothiepins; D000639:Amitriptyline; D004308:Dothiepin