title: [Participation of serotonin in demonstration of predatory aggression in the mouse].
abstract: The study was devoted to the influence of serotonin (5-HT) on the mice predatory aggression towards locusts which was estimated by the latency of attack and the number of aggressive mice in the experimental group. 10 mg/kg of 5-HT injected intraperitoneally, significantly decreased the percentage of aggressive mice and prolonged the attacks latency. 5-Hydroxytryptophan (5-HTP), 5-HT precursor, had a more prominent inhibitory effect which was significant when the dose amounted to 50 mg/kg. Imipramin, an inhibitor of 5-HT reuptake, diminished predatory aggression in dose-dependent manner. Pretreatment of metisergid (blockader of 5-HT receptors) prevented the inhibitory effect of 5-HTP. 5-HT suppressing influence on mice predatory aggression is due by its action on central mechanisms as the injection of small doses of 5-HT in the mice lateral ventricle considerably decreased their aggression towards locusts.
mesh_terms: D000374:Aggression / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001070:Appetitive Behavior / Q000502:physiology*; D006110:Grasshoppers; D006801:Humans; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D011235:Predatory Behavior / Q000187:drug effects / Q000502:physiology*; D011930:Reaction Time / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology / Q000502:physiology*
chemical_list: D012701:Serotonin
vernacular_title: Ob uchastii serotonina v proiavenii khishchnikcheskoĭ agressii u mysheĭ.