[Cardiotoxicity of fenoterol - ultramorphologic and morphometric studies of the rabbit myocardium].
Beta-sympathomimetic drugs in large doses can induce necrosis of the myocardium, according to animal-experimental studies mainly with isoproterenol. In the instance of its broad clinical application in tocolysis a possible cardiotoxic effect of fenoterol has also been discussed. It was interesting to study the ultramorphologic effects of fenoterol on rabbit myocardium after a ten-day-application period. These tests revealed no myocardial-toxic alterations after monotherapy or in combination with verapamil or prednisolone (applying therapy-equivalent doses); a morphometric-statistical analysis confirmed these findings.
D000014:Abnormalities, Drug-Induced / Q000517:prevention & control; D000818:Animals; D004983:Ethanolamines / Q000009:adverse effects*; D005260:Female; D005280:Fenoterol / Q000009:adverse effects*; D005318:Fetal Heart / Q000187:drug effects* / Q000648:ultrastructure; D008854:Microscopy, Electron; D009206:Myocardium / Q000473:pathology; D011817:Rabbits
D004983:Ethanolamines; D005280:Fenoterol
Zur Kardiotoxizität des Fenoterol - Ultramorphologische und morphometrische Untersuchungen am Kaninchenmyokard.