Electrolyte and glucose metabolism in VX-2 carcinoma of the rabbit.
Biochemical and other parameters in VX-2 carcinoma in rabbits were evaluated. VX-2 carcinoma not only produced hypercalcemia but also hypophosphatemia and 25-OH-vitamin D deficiency. An increased turnover of 25-OH-vitamin D seems likely. Serum parathyroid hormone and urinary cyclic AMP did not increase. Hypokalemia occurred in association with hypophosphatemia and lowered blood glucose within 1 week after tumor transplantation. At the end of the experiment glucose and insulin were both below the control range. It is concluded that VX-2 carcinoma in rabbits yields much more complex biochemical alterations than reported before on calcium metabolism.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D002112:Calcifediol / Q000097:blood; D002118:Calcium / Q000097:blood; D004573:Electrolytes / Q000097:blood*; D005260:Female; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000097:blood; D010758:Phosphorus / Q000097:blood; D011817:Rabbits; D012709:Serum Albumin / Q000032:analysis
D001786:Blood Glucose; D004573:Electrolytes; D010281:Parathyroid Hormone; D012709:Serum Albumin; D010758:Phosphorus; D002112:Calcifediol; D002118:Calcium