Pyrolytic products from tryptophan and glutamic acid are positive in the mammalian spot test.
Pyrolysates of tryptophan (Trp-P-2) and glutamic acid (Glu-P-1) are known mutagens in in vitro short term mutagenicity tests, and have also shown carcinogenic effects in long term animal studies. The present study demonstrates that they also produce mutations in somatic cells. This result demonstrates the ability of the test to detect carcinogenic and mutagenic compounds.
D000818:Animals; D002243:Carbolines / Q000633:toxicity*; D002273:Carcinogens; D005260:Female; D006200:Hair Color; D007093:Imidazoles / Q000633:toxicity*; D007211:Indoles / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D008098:Litter Size; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D011247:Pregnancy
D002243:Carbolines; D002273:Carcinogens; D007093:Imidazoles; D007211:Indoles; D009153:Mutagens; C023785:2-amino-6-methyldipyrido(1,2-a-3',2'-d)imidazole; C019133:3-amino-1-methyl-5H-pyrido(4,3-b)indole