Effect of flutamide, a nonsteroidal antiandrogen on functional maturation of the epididymis of rat.
The effect of flutamide, a non-steroidal antiandrogen on the growth and secretory function of the epididymis of rat during transition from prepubertal age (35 days old) to puberty (50 days old) was investigated. The results showed that the antiandrogen interfered with the growth of all the genital organs accompanied by a marked reduction in the secretory function of the epididymis as revealed by lowered levels of sialic acid and glycerylphosphorylcholine. These findings are discussed in relation to our previous observations in adult rats.
D000813:Anilides / Q000494:pharmacology*; D000818:Animals; D004822:Epididymis / Q000254:growth & development* / Q000378:metabolism; D005485:Flutamide / Q000494:pharmacology*; D005837:Genitalia, Male / Q000254:growth & development; D005997:Glycerylphosphorylcholine / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D012741:Sexual Maturation / Q000187:drug effects*; D012794:Sialic Acids / Q000378:metabolism
D000813:Anilides; D012794:Sialic Acids; D005997:Glycerylphosphorylcholine; D005485:Flutamide