title: Central depressive action of two N-aminomethyl derivatives of diethylpyridinedione.
abstract: The central depressive action of N-aminomethylmorpholine-3,3-diethyl-2,4-pyridinedione (DKMM) and N-aminomethylpiperazine-3,3-diethyl-2,4-pyridinedione (DKMP), compounds having a marked anticonvulsive effect, has been studied applying a set of methods characterizing this action. DKMM and DKMP are found to prolong hexobarbital, chlorhydrate and alcohol sleeping time. Investigated by the modified jumping test, the two substances inhibit the central nervous system to the same degree. They show at the same time properties of hypnosedatives and neuroleptics as well. DKMM and DKMP manifest motor-incoordination activity in doses nearly 3.5 times higher than the doses inhibiting corazol convulsions. The compounds have a marked antiaggressive effect in the case of isolation syndrome, particularly pronounced for DKMP in a dose of 1/12 of LD50. The results obtained show that DKMM and DKMP are central depressants with marked sedative-tranquillizing action.
mesh_terms: D000374:Aggression / Q000187:drug effects; D000661:Amphetamine / Q000633:toxicity; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D006801:Humans; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010433:Pentylenetetrazole / Q000494:pharmacology; D011728:Pyridones / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects
chemical_list: D000927:Anticonvulsants; D011728:Pyridones; C033226:N-aminomethylmorpholine 3,3-diethyl-2,4-pyridinedione; C033227:N-aminomethylpiperazine 3,3-diethyl-2,4-pyridinedione; D000661:Amphetamine; D010433:Pentylenetetrazole