title: Treatment of adult autoimmune thrombocytopenic purpura with high-dose intravenous plasmin-cleaved gammaglobulins.
abstract: We present the results of the treatment of 15 adult patients with chronic autoimmune thrombocytopenic purpura with high dose i.v. gammaglobulins. In 11 patients, this treatment produced a remission, complete (platelet counts above 100 X 10(9)/l) in 5, partial (platelet counts between 50 and 100 X 10(9)/l) in 6. In all these patients, the response was transient lasting 2-4 weeks. In 4 patients, no response was observed. We used plasmin-cleaved gammaglobulins which caused rare and mild side effects and gave results similar to those reported with intact human gammaglobulins. The indications of high dose i.v. gamma-globulins in the management of adult patients with autoimmune thrombocytopenic purpura are discussed.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011697:Purpura, Thrombotic Thrombocytopenic / Q000097:blood / Q000628:therapy*
chemical_list: D007074:Immunoglobulin G