Chromic anhydride-3, 5-dimethylpyrazole complex: an efficient reagent for oxidation of steroidal estrogens to 6-oxo-derivatives.
An efficient procedure for the oxidation of steroidal estrogens to the corresponding 6-oxo-derivatives is described. The oxidative process involves the use of 3,5-dimethylpyrazole-chromium trioxide complex at low temperature (-20 degrees). Under these conditions, only the 6-oxo-derivative and the unreacted starting material were obtained and the latter could be subjected to oxidation once again to obtain additional amount of 6-oxo-derivative.
D055598:Chemical Phenomena; D002621:Chemistry; D002857:Chromium; D004967:Estrogens / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D010084:Oxidation-Reduction; D011720:Pyrazoles
D004967:Estrogens; D007202:Indicators and Reagents; D011720:Pyrazoles; C043136:chromic anhydride-3,5-dimethylpyrazole complex; D002857:Chromium