title: Electrophysiological effects of lidocaine in acute myocardial infarction with bifascicular block or complete A-V block.
abstract: Electrophysiological effects of lidocaine were studied in 27 patients with acute myocardial infarction complicated by bifascicular block (group I: 20), and complete A-V block (group II: 7). Lidocaine was administered intravenously in bolus doses of 100 mg each at intervals of 10 min. In group I, there was no significant change in the heart rate (Before (B) = 84.85 +/- 24.19, After (A) = 87.25 +/- 20.26 beats/min) intra-atrial (PA) conduction time (B = 25 +/- 6.18, A = 27.22 +/- 6.69 ms), A-V nodal (AH) conduction (B = 111.5 +/- 56.12, A = 111.5 +/- 56.5 ms) or His bundle to ventricular (HV) activation time (B = 59.5 +/- 19.32, A = 61.25 +/- 18.62 ms) after lidocaine administration. In group II, 2 patients reverted to sinus rhythm, one with 1:1 conduction and the other with type II Wenckebach's block, with being prepared for the study, but both had complete A-V block within 1 h of the His bundle electrogram recordings. Of the remaining 5 patients, 4 had supra and 1 infra His A-V block. After lidocaine, 2 patients developed asystole. In the remaining 4 patients, there was no change in the escape rate or various conduction intervals.
mesh_terms: D000368:Aged; D002037:Bundle-Branch Block / Q000188:drug therapy; D004562:Electrocardiography; D005260:Female; D006327:Heart Block / Q000188:drug therapy*; D006329:Heart Conduction System / Q000187:drug effects*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy*
chemical_list: D008012:Lidocaine