Nocodazole inhibits polyI:C induction of interferon by mouse macrophages.
Mouse bone marrow-derived macrophages respond to both viral and nonviral inducers of interferon (IFN). The effect of nocodazole, an antitubulin drug, on the induction of IFN by either polyinosinic:polycytidylic acid, or Newcastle disease virus was studied in mouse macrophages. Nocodazole, 0.5 microM and 15 microM, maximally inhibited polyI:C induction of IFN in bone marrow-derived macrophages and resident peritoneal macrophages, respectively, but had no effect on Newcastle disease virus (NDV) induction of IFN.
D000818:Animals; D001562:Benzimidazoles / Q000494:pharmacology*; D003078:Colchicine / Q000494:pharmacology; D005260:Female; D005786:Gene Expression Regulation; D007369:Interferon Inducers / Q000494:pharmacology*; D007370:Interferon Type I / Q000096:biosynthesis*; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D015739:Nocodazole; D011070:Poly I-C / Q000037:antagonists & inhibitors*
D001562:Benzimidazoles; D007369:Interferon Inducers; D007370:Interferon Type I; D011070:Poly I-C; D015739:Nocodazole; D003078:Colchicine