Method of analysis of the new cardiotonic agent, MDL 19,205, in plasma and urine and its application in a dog pharmacokinetic study.
A high-performance liquid chromatographic method has been developed for the analysis of plasma and urine concentrations of a new cardiotonic agent, MDL 19,205 (I). This procedure was utilized to study the pharmacokinetics of I in beagle dogs. The results of the dog study show that the compound is completely and rapidly absorbed. Plasma concentrations fell in a monoexponential manner with a half-life of about 1.3 h which was unaffected by dose in the range 3-30 mg/kg. Urinary excretion of unchanged I accounts for about one-half of the dose and is essentially complete in 24-48 h.
D000284:Administration, Oral; D000818:Animals; D002316:Cardiotonic Agents / Q000032:analysis* / Q000097:blood / Q000652:urine; D004285:Dogs; D006207:Half-Life; D007093:Imidazoles / Q000032:analysis* / Q000097:blood / Q000652:urine; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male
D002316:Cardiotonic Agents; D007093:Imidazoles; C039686:piroximone