Pyrrolomycins C, D and E, new members of pyrrolomycins.
Pyrrolomycins C, D and E, new members of pyrrolomycins produced by Actinosporangium vitaminophilum SF-2080, have been isolated by chromatography on a basic alumina column. Three antibiotics have chlorinated pyrrole nuclei linked directly or via carbonyl function to the dichlorophenol moiety. Pyrrolomycins C and E are active against Gram-positive bacteria, while the spectrum of pyrrolomycin D is broad including Gram-positive, Gram-negative bacteria and fungi.
D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000254:growth & development*; D011758:Pyrroles / Q000302:isolation & purification / Q000633:toxicity; D013045:Species Specificity; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D011758:Pyrroles; C034690:pyrrolomycin C; C034691:pyrrolomycin D; C039863:pyrrolomycin E