title: Synthesis of orally active cardiosteroid derivatives.
abstract: Starting from hellebrigenin, orally cardiotonic active acylcardiosteroid derivatives have been synthesized. D 12316 (acrihellin), the hellebrigenin-3 beta-dimethylacrylate, has been chosen for clinical evaluation.
mesh_terms: D000818:Animals; D002018:Bufanolides / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D002301:Cardiac Glycosides / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D002415:Cats; D055598:Chemical Phenomena; D002621:Chemistry; D004077:Digoxin / Q000494:pharmacology; D004562:Electrocardiography
chemical_list: D002018:Bufanolides; D002301:Cardiac Glycosides; C001330:hellebrigenin; D004077:Digoxin