title: Thymic hormone containing cells. III. Evidence for a feed-back regulation of the secretion of the serum thymic factor (FTS) by thymic epithelial cells.
abstract: Cells containing the serum thymic factor (FTS), as measured by indirect immunofluorescence, were studied in mice either FTS depleted by injection of anti-FTS monoclonal antibodies or immunization against FTS coupled to bovine serum albumin (FTS-BSA), or FTS enriched by multiple injections of synthetic thymulin (FTS-Zn). Injections of thymulin did not significantly depress FTS secretion. Conversely, long term elimination of FTS from peripheral blood caused a great increase in the thymic intracellular content of FTS, as evidenced by the higher number of FTS containing cells observed with immunofluorescence. These data could provide the first evidence of a feed-back control of thymic endocrine function.
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D005246:Feedback; D005260:Female; D007114:Immunization; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D013935:Thymic Factor, Circulating / Q000276:immunology / Q000378:metabolism* / Q000494:pharmacology; D013950:Thymus Gland / Q000166:cytology / Q000378:metabolism*; D013951:Thymus Hormones / Q000378:metabolism*
chemical_list: D000911:Antibodies, Monoclonal; D013951:Thymus Hormones; D013935:Thymic Factor, Circulating