title: Modification of immune responsiveness to tumour grafts (enhancement or inhibition) induced in mice by allogeneic embryos.
abstract: Immune reactivity of the female recipients, made artificially pregnant, of fully allogeneic embryos was investigated. Allogeneic blastocysts were transferred into hormonally synchronized foster mothers in two strain combinations A (H-2a)--CBA (H-2k) and C57BL/6 (H-2b)--DBA/2 (H-2d). Immunogenicity was tested by growth of tumours Sa 1 (syngeneic with A strain recipients) and EL 4 (syngeneic with C57BL/6 strain recipients). Allogeneic blastocysts implanted in the host's uterus are able to elicit a stronger immune response than in semi-syngeneic pregnancies. The immune reaction was manifested by enhanced growth of tumour Sa 1 and accelerated rejection of EL 4.
mesh_terms: D000818:Animals; D004624:Embryo Transfer; D004622:Embryo, Mammalian / Q000276:immunology; D005260:Female; D006082:Graft Enhancement, Immunologic; D006084:Graft Rejection; D006085:Graft Survival; D006183:H-2 Antigens / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology*; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000276:immunology; D011270:Pregnancy, Animal; D011555:Pseudopregnancy / Q000276:immunology; D014184:Transplantation, Homologous
chemical_list: D006183:H-2 Antigens