title: [Serum and urine electrolyte behavior under therapeutic dosage of a potent magnesium and aluminum hydroxide containing antacid].
abstract: Report is given concerning a clinical study on 15 healthy volunteers who received 4 x 10 ml/die Maalox 70 or placebo. The influence on the serum electrolytes calcium, magnesium, aluminium, and the phosphate concentration has been determined by daily monitoring. Furthermore the renal elimination rates for calcium, magnesium, aluminium, and phosphate as well as urine pH, and osmolality have been determined. The quality of stools of the volunteers was monitored. The results were proved statistically. The study led to the following results: The drug has been tolerated subjectively. The stool quality and quantity of the subjects did not change. Magnesium- and aluminium concentration in serum shifted to higher concentrations. At the same time the renal magnesium- and aluminium excretion increased, and the phosphate elimination decreased. This shifting was within the physiological limits, so that relevant clinical side effects could not be observed. All other parameters did not change.
mesh_terms: D000293:Adolescent; D000328:Adult; D000535:Aluminum / Q000097:blood; D000536:Aluminum Hydroxide / Q000494:pharmacology*; D000863:Antacids / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D004338:Drug Combinations / Q000494:pharmacology; D004573:Electrolytes / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000097:blood / Q000494:pharmacology*; D008276:Magnesium Hydroxide / Q000494:pharmacology*; D009994:Osmolar Concentration; D010710:Phosphates / Q000097:blood; D013997:Time Factors
chemical_list: D000863:Antacids; D004338:Drug Combinations; D004573:Electrolytes; D010710:Phosphates; C013591:aluminum hydroxide, magnesium hydroxide, drug combination; D000536:Aluminum Hydroxide; D000535:Aluminum; D008274:Magnesium; D008276:Magnesium Hydroxide; D002118:Calcium
vernacular_title: Serum- und Urin-Elektrolytverhalten unter therapeutischer Dosierung eines potenten Magnesium- und Aluminiumhydroxid-haltigen Antazidums.