Development of a neo-artery induced by a biodegradable polymeric vascular prosthesis.
A microporous, compliant and biodegradable vascular prosthesis prepared from a polyurethane-poly-L-lactic-acid (PU-PLLA) mixture, induces fast growth of a neo-artery after implantation as an arterial substitute. The prostheses used in this study resulted in 100% patency. Mechanical functionality of the neo-arteries is suggested by the regeneration of elastic laminae throughout the subintimal tissue. The fact that elastogenesis occurs in our biodegradable PU-PLLA graft may be a step forward in solving the problem of how to maintain a natural compliance in vascular prostheses.
D000818:Animals; D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis; D004549:Elastin / Q000032:analysis; D005069:Evaluation Studies as Topic; D007773:Lactates; D019344:Lactic Acid; D008297:Male; D008855:Microscopy, Electron, Scanning; D011091:Polyesters; D011108:Polymers; D011140:Polyurethanes; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D001672:Biocompatible Materials; D007773:Lactates; D011091:Polyesters; D011108:Polymers; D011140:Polyurethanes; D019344:Lactic Acid; C033616:poly(lactide); D004549:Elastin