The pontine reticular formation is part of the output pathway for amphetamine- and apomorphine-induced lateral head movements: evidence from experimental lesions in the rat.
Electrolytic lesions in the caudal part of the medial pontine reticular formation (PRF) in the rat abolished apomorphine- or amphetamine-induced stereotypic lateral head movements and turning to the damaged side. Rats with unilateral PRF lesions turned and circled only to the intact side, and rats with bilateral lesions did not turn at all. PRF lesions were also effective in abolishing or reducing amphetamine-induced circling in rats with unilateral nigrostriatal bundle damage. Thus, head movements induced by dopamine agonists are added to the class of head movements mediated by the PRF. It is proposed that the decussations of the motor pathways for drug-induced turning are located between the midbrain and caudal pons.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology*; D004292:Dominance, Cerebral / Q000187:drug effects*; D006801:Humans; D009043:Motor Activity / Q000187:drug effects*; D009434:Neural Pathways / Q000187:drug effects; D011149:Pons / Q000187:drug effects*; D051381:Rats; D012154:Reticular Formation / Q000187:drug effects*; D013239:Stereotyped Behavior / Q000187:drug effects*; D013378:Substantia Nigra / Q000187:drug effects
D001058:Apomorphine; D003913:Dextroamphetamine