Some characteristics of acute inflammation induced by econazole.
Aqueous suspension of econazole nitrate injected into subplantar region of rat foot induces a sharp and long-lasting inflammation. The econazole-induced edema is characterized by the existence of two phases of accelerated evolution, with peak values at 2nd and 12th hr after injection. Only the second phase of econazole-induced edema is selectively inhibited by either steroidal or non-steroidal anti-inflammatory drugs.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology; D004464:Econazole / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004487:Edema / Q000139:chemically induced; D007093:Imidazoles / Q000633:toxicity*; D007249:Inflammation / Q000139:chemically induced*; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D007093:Imidazoles; D004464:Econazole; D003907:Dexamethasone; D010653:Phenylbutazone