title: Effect of hypercalcaemia on adrenocortical and growth hormone secretion.
abstract: The authors investigated in 19 healthy women changes in the plasma levels of cortisol and growth hormone during acute hypercalcaemia induced by a load of 8.9 mg Ca2+/kg body weight, administered as intravenous infusion and the effect of hypercalcaemia on the adrenocortical and somatotrophic secretory reserve assessed by the test with insulin hypoglycaemia. Hypercalcaemia causes a rise of the basal cortisol plasma level starting at the 90th minute from the onset of the infusion when the calcium level reaches values of 2.99 mmol/l. The adrenocortical secretory reserve is, however, significantly reduced by hypercalcaemia. Hypercalcaemia does not affect growth levels nor the somatotrophic secretory reserve.
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000097:blood* / Q000378:metabolism; D000328:Adult; D002118:Calcium / Q000097:blood; D005260:Female; D013006:Growth Hormone / Q000097:blood* / Q000378:metabolism; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006934:Hypercalcemia / Q000378:metabolism*; D008274:Magnesium / Q000097:blood; D008875:Middle Aged
chemical_list: D000305:Adrenal Cortex Hormones; D013006:Growth Hormone; D008274:Magnesium; D002118:Calcium; D006854:Hydrocortisone