Glycoursodeoxycholate is as effective as tauroursodeoxycholate in preventing the taurocholate-induced cholestasis in the rat.
A combined infusion of taurocholate (TC) and glycoursodeoxycholate (GU) resulted in a longer choleretic period and a significantly higher excretion of TC compared with the infusion of TC alone, as has been previously observed for the combined infusion of tauroursodeoxycholate (TU) and TC in the rat. It was concluded that GU is as effective as TU in preventing TC induced cholestasis in this species.
D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D001647:Bile Acids and Salts / Q000032:analysis; D002635:Chenodeoxycholic Acid / Q000031:analogs & derivatives*; D002779:Cholestasis / Q000139:chemically induced / Q000517:prevention & control*; D003840:Deoxycholic Acid / Q000031:analogs & derivatives*; D004353:Drug Evaluation, Preclinical; D051381:Rats; D012636:Secretory Rate / Q000187:drug effects; D013655:Taurochenodeoxycholic Acid / Q000627:therapeutic use*; D013656:Taurocholic Acid / Q000494:pharmacology*; D014580:Ursodeoxycholic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use
D001647:Bile Acids and Salts; D003840:Deoxycholic Acid; D002635:Chenodeoxycholic Acid; D013655:Taurochenodeoxycholic Acid; D013656:Taurocholic Acid; C031655:ursodoxicoltaurine; C024033:glycoursodeoxycholic acid; D014580:Ursodeoxycholic Acid