Methamphetamine mortality to emotional stimuli administered in the form of affective communication.
Methamphetamine induced mortality in physically stressed and non-physically stressed mice was investigated by employing a communication box in which shocked mice communicated their distress to unshocked mice in neighboring boxes. Intraperitoneal administration of methamphetamine 30 mg/kg caused greater mortality in both the shocked "sender" mice and the unshocked "responder" mice than in control when maintained at 27 +/- 1 degree C. Forty-eight hours after injection, the "sender", "responder" and control mice showed mortality of 80, 60 and 10%, respectively. This result indicates that the mortality of methamphetamine may be potentiated not only by physical stress but also by non-physical stress.
D000819:Animal Communication; D000818:Animals; D004597:Electroshock; D004644:Emotions; D006801:Humans; D008297:Male; D008694:Methamphetamine / Q000633:toxicity*; D051379:Mice; D012919:Social Behavior; D012934:Social Isolation; D013312:Stress, Physiological / Q000401:mortality*; D013315:Stress, Psychological / Q000401:mortality*; D013696:Temperature; D013997:Time Factors
D008694:Methamphetamine