Vaccination against spontaneous abortion in mice.
We report here that the high rate of spontaneous resorption observed in CBA/J female mice mated with DBA/2 J males can be dramatically reduced by vaccination with Balb/c male spleen cells, but not by CBA/J or DBA/2 J male spleen cells. This effect correlates with the differential ability of Balb/c spleen cells to induce MLR suppressor activity in CBA/J female mice, and should lead to a better understanding of the immunology of the materno-fetal relationship.
D000026:Abortion, Habitual / Q000517:prevention & control*; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005313:Fetal Death / Q000517:prevention & control*; D005327:Fetal Resorption / Q000276:immunology / Q000517:prevention & control* / Q000662:veterinary; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008808:Mice, Inbred CBA / Q000276:immunology; D008811:Mice, Inbred DBA / Q000276:immunology; D008815:Mice, Inbred Strains / Q000276:immunology*; D011247:Pregnancy; D012376:Rodent Diseases / Q000276:immunology; D013154:Spleen / Q000276:immunology; D014611:Vaccination