The dual effects of aluminum as activator and inhibitor of adenylate cyclase in the liver fluke Fasciola hepatica.
The liver fluke, Fasciola hepatica, has a very active adenylate cyclase which can be stimulated by NaF or by serotonin and guanine nucleotides. Micromolar amounts of AlCl3 augment the activation by F-. In contrast, when the enzyme is activated with serotonin and guanine nucleotides, AlCl3 inhibits the activation. Aluminum also inhibits the activation by forskolin. Gallium mimics the effects of aluminum.
D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism*; D000535:Aluminum / Q000494:pharmacology*; D000077410:Aluminum Chloride; D017607:Aluminum Compounds; D000818:Animals; D002712:Chlorides; D005576:Colforsin; D004224:Diterpenes / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D005210:Fasciola hepatica / Q000201:enzymology*; D006160:Guanosine Triphosphate / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D012969:Sodium Fluoride / Q000494:pharmacology
D000067956:Adenylyl Cyclase Inhibitors; D017607:Aluminum Compounds; D002712:Chlorides; D004224:Diterpenes; D005576:Colforsin; D012701:Serotonin; D000077410:Aluminum Chloride; D006160:Guanosine Triphosphate; D012969:Sodium Fluoride; D000535:Aluminum; D000262:Adenylyl Cyclases