title: Persistent anthelmintic effect of ivermectin in cattle.
abstract: The persistent anthelmintic effect of ivermectin given subcutaneously at 200 mcg/kg was evaluated against induced infections of Haemonchus placei, Ostertagia ostertagi, Cooperia spp. (C. pectinata and C. punctata), Bunostomum phlebotomum and Oesophagostomum radiatum in cattle. Forty-four Friesian bull calves raised under worm-free conditions were restrictively randomized to one untreated control group and 3 ivermectin treated groups of equal size according to mass. Animals in the different treated groups were treated either 9, 7 or 5 d before infestation, which was induced in all animals on the same day. The results are presented as percentage reduction and Non Parametric claims. Nine days after treatment the effect of ivermectin was virtually undiminished against O. ostertagi and B. phlebotomum and 7 d after treatment against Cooperia spp. Counts of all worms were reduced by 99% or more following the treatment given 5 d before infection. According to the Non Parametric Method, "A" claims (i.e. 80% effective in 80% of the treated animals) were achieved against all 5 worms up to 7 d after treatment and against O. ostertagi and B. phlebotomum up to 9 d after treatment.
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy*; D007559:Ivermectin; D007783:Lactones / Q000627:therapeutic use*; D008297:Male; D013997:Time Factors; D014252:Trichostrongyloidiasis / Q000188:drug therapy / Q000662:veterinary*
chemical_list: D000871:Anthelmintics; D007783:Lactones; D007559:Ivermectin