Increased production of mononuclear cell procoagulant activity in Hodgkin's disease.
Procoagulant activity of peripheral blood mononuclear leucocytes was studied in 24 consecutive patients with Hodgkin's disease. Mononuclear cells, tested immediately after isolation, expressed very low activity which was, however, somewhat higher than that of cells from a matched control group (P = 0.063). Procoagulant activity generated by patients' mononuclear cells following stimulation with bacterial endotoxin was significantly higher than that produced by control cells (P less than 0.01). There was no apparent relation between procoagulant activity and pathological staging. The increased capacity of mononuclear phagocytes to produce procoagulant activity might help explain activation of blood coagulation and subsequent fibrin deposition in patients with Hodgkin's disease.
D000328:Adult; D004731:Endotoxins / Q000494:pharmacology; D005260:Female; D006689:Hodgkin Disease / Q000097:blood* / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism*; D009367:Neoplasm Staging; D010835:Phytohemagglutinins / Q000494:pharmacology; D013925:Thromboplastin / Q000096:biosynthesis*
D004731:Endotoxins; D010835:Phytohemagglutinins; D013925:Thromboplastin