title: [X-ray study of pH-dependence of thick filament structure in stripped fiber bundles of vertebrate skeletal muscles].
abstract: Molecular origin of pH-dependence of rigor tension in chemically skinned fibre bundles of rabbit psoas muscle was studied with the help of X-ray diffraction technique. It was found that a shift of pH from the neutral value of about 7.0 either to basic or to acidic regions by one unit is accompanied by changes of relative intensities in a number of meridional reflections. These effects are explained as the result of pH-induced detachment of subfragments-2 of myosin molecules from the thick filament surface. The data obtained indicate that force generation in muscle may be caused by the structural changes of subfragments-2 of myosin molecules.
mesh_terms: D000818:Animals; D003599:Cytoskeleton / Q000648:ultrastructure*; D006863:Hydrogen-Ion Concentration; D009119:Muscle Contraction; D009132:Muscles / Q000648:ultrastructure*; D011817:Rabbits; D014961:X-Ray Diffraction
vernacular_title: Rentgenograficheskoe izuchenie zavisimosti ot pH struktury tolstykh niteĭ v demembranizirovannykh puchkakh volokon skeletnykh myshts pozvonochnykh.