title: [Antiviral agents. 22. N-aliphatic, N-alicyclic and N-polycyclic substituted N'-(2-adamantyl)ureas and -thioureas].
abstract: With reference to the role that (2-adamantyl), urea, and thiourea moieties play in antiviral drugs, these structural elements have been included in the present investigations aimed at the development of the N-substituted N'-(2-adamantyl)-thioureas 3a-d through the reaction of 2-aminoadamantane (1) with the isothiocyanates 2a-d. In an analogous manner, the interaction of 1 with the isocyanates 2e-f has led to the N-substituted N'-(2-adamantyl)ureas 3e-f. Within structure type 3 there occur representatives exhibiting antiviral, antimycotic, and herbicidal activity.
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D000935:Antifungal Agents / Q000138:chemical synthesis; D000998:Antiviral Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006540:Herbicides / Q000138:chemical synthesis
chemical_list: D000935:Antifungal Agents; D000998:Antiviral Agents; D006540:Herbicides; D000218:Adamantane
vernacular_title: Antivirale Wirkstoffe. 22. Mitt.: N-Aliphatisch, N-alizyklisch und N-polyzyklisch substituierte N'-(2-Adamantyl)harnstoffe und -thioharnstoffe).