Exercising muscle does not produce hypoxanthine in adenylate deaminase deficiency.
The failure of forearm exercise to increase plasma hypoxanthine in subjects with adenylate deaminase deficiency confirms this enzyme's role in hypoxanthine production by normal forearm exercise. The conversion of adenosine monophosphate (AMP) to hypoxanthine may reflect an alternative method of adenosine triphosphate (ATP) regeneration in working muscle.
D000659:AMP Deaminase / Q000172:deficiency*; D000249:Adenosine Monophosphate / Q000378:metabolism; D000293:Adolescent; D005260:Female; D005542:Forearm; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism*; D009709:Nucleotide Deaminases / Q000172:deficiency*; D005082:Physical Exertion
D007042:Hypoxanthines; D019271:Hypoxanthine; D000249:Adenosine Monophosphate; D009709:Nucleotide Deaminases; D000659:AMP Deaminase