title: Experimental animal epilepsy. A new device for the induction of epileptic seizures in the murine, El mouse.
abstract: A new apparatus was constructed for the induction of seizures in El mouse carrying inheritable epileptic features. They were rotated vertically in a drum with a 15 cm radius at the rate of two rotations per second. This procedure was repeated once a week. At the beginning of the experiment, the seizures occurred on an average of 20 rotations per mouse. This markedly decreased to only two rotations, six weeks thereafter. The acceleration which was effective for the induction of seizures in the El mouse, calculated in this apparatus, was 2369 +/- 980 cm/sec2. A rodent, Mongolian gerbil was also briefly described, comparing the seizure patterns with the El mouse.
mesh_terms: D000054:Acceleration; D000818:Animals; D004195:Disease Models, Animal; D004827:Epilepsy / Q000209:etiology*; D005849:Gerbillinae; D009115:Muridae; D010812:Physical Stimulation / Q000295:instrumentation; D012399:Rotation