Medulloepithelioma diagnosed by ultrasound and vitreous aspirate. Electron microscopic observations.
Ultrasonography and cytologic examination of the vitreous aspirate established the correct pre-enucleation diagnosis of medulloepithelioma in the case of an 8-year-old boy. The use of a muscle hook allowed the examiner to elevate the eye and bring the ciliary body into adequate ultrasonographic view. Histopathologic examination of the enucleated eye showed a partially pigmented mass composed of elongated neuroepithelial tubules and cords arising from the ciliary body inferiorly. Several tubules displayed a central lumen with rosette-like structures. The tumor was classified as a benign, nonteratoid medulloepithelioma. Electron microscopically the lumens of the rosettes contained myriad, slender microvilli, and were bordered by numerous terminal bar complexes and areas displaying zonula adherens and zonula occludens type junctions. Additionally, invaginating gap junctions, which clearly established that the tumor originated from the ciliary epithelium, were identified.
D001707:Biopsy, Needle; D002386:Cataract / Q000473:pathology; D002648:Child; D002924:Ciliary Body / Q000648:ultrastructure*; D003937:Diagnosis, Differential; D004848:Epithelium / Q000473:pathology; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D018241:Neuroectodermal Tumors, Primitive, Peripheral / Q000648:ultrastructure*; D014604:Uveal Neoplasms / Q000648:ultrastructure*; D014822:Vitreous Body / Q000648:ultrastructure*