[Chronic alcoholic intoxication in animals as a model for the study of the safety of new anti-alcohol agents].
Experiments on 200 noninbred male rats have demonstrated that daily administration of ethanol per os in a dose of 8 g/kg (2/3 LD50) for a month produced pathological changes in organs and systems of the body, which were similar to the manifestations of chronic alcoholic intoxication in man. It is concluded that the model under consideration may be used during preclinical study of the safety of new antialcoholic agents.
D000427:Alcohol Deterrents / Q000633:toxicity*; D000437:Alcoholism / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D000818:Animals; D001769:Blood / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D051381:Rats; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000187:drug effects; D013997:Time Factors
D000427:Alcohol Deterrents
Khronicheskaia alkogol'naia intoksikatsiia u zhivotnykh kak model' dlia izucheniia bezopasnosti novykh protivoalkogol'nykh sredstv.