Hemodynamic activity of different doses of sulmazole by infusion.
By means of right heart catheterisation and thermodilution the hemodynamic response to two different doses of 2-[2-methoxy-4-(methylsulfinyl) phenyl]-1H-imidazo[4,5-b]pyridine (sulmazole, AR-L 115 BS, Vardax) (1.5 mg or 0.7 mg/min) was determined in 10 hospitalized patients with congestive cardiac insufficiency. It was found that sulmazole has a marked positive inotropic effect, increasing the cardiac output and stroke work index and decreasing the peripheral systemic and pulmonary vascular resistance, almost without altering the blood pressure values; furthermore, it reduces the right atrial pressure, the pulmonary capillary pressure and the pulmonary arterial pressure. Tolerance of sulmazole was excellent; no tachyphylaxis nor rebound reactions were observed during the 36-h period of medication.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002316:Cardiotonic Agents / Q000097:blood / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006333:Heart Failure / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007093:Imidazoles / Q000097:blood / Q000494:pharmacology*; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D002316:Cardiotonic Agents; D007093:Imidazoles; C029758:sulmazole