Intranuclear tonofilament-like filaments in skin carcinoma.
Electron microscopical investigations of untreated solar keratosis, squamous cell carcinoma, and Bowen carcinoma showed intranuclear bundles of intermediate filaments in suprabasal keratinocytes. We found evidence that the filaments are incorporated into the nucleus during atypical mitosis.
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000648:ultrastructure*; D002467:Cell Nucleus / Q000648:ultrastructure*; D003599:Cytoskeleton / Q000648:ultrastructure*; D006801:Humans; D007642:Keratosis / Q000473:pathology; D012867:Skin / Q000648:ultrastructure*; D012878:Skin Neoplasms / Q000648:ultrastructure*