Effects of naloxone infusion on basal and breast-stimulation-induced prolactin secretion in puerperal women.
The effects of naloxone infusion on plasma prolactin (PRL) levels and on the PRL response to mechanical breast emptying were investigated in a group of puerperal women, Five, 10, and 20 mg naloxone administered to women on days 2 to 3 of the puerperium produced no significant change in serum PRL. The same dose of naloxone had no significant effect on serum PRL response to mechanical breast stimulation in puerperal women. The results suggest that endogenous opioid peptides are not major modulators of PRL secretion in the puerperium.
D000328:Adult; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007774:Lactation; D008722:Methods; D009270:Naloxone / Q000008:administration & dosage*; D049590:Postpartum Period; D011247:Pregnancy; D011388:Prolactin / Q000378:metabolism*
D009270:Naloxone; D011388:Prolactin