Spontaneous gastric erosions in NOD and KK-A gamma.
Histopathological examinations of stomachs of insulin-dependent (NOD) and noninsulin-dependent (KK-A gamma) mice were carried out. Spontaneous erosions in the fundic area were observed in 31% of NOD and 35% of KK-A gamma mice. The morphological features of the erosions were similar to those of erosions produced by stress. Although no erosions were detected in nondiabetic C3H/Slc mice raised and maintained in the same animal room, the presence of hyperglycemia and glycosuria in NOD and KK-A gamma mice did not appear to have a direct correlation with development of erosions. NOD and KK-A gamma mice may be useful animal models for human stress ulcers.
D000818:Animals; D003922:Diabetes Mellitus, Type 1 / Q000662:veterinary; D003924:Diabetes Mellitus, Type 2 / Q000662:veterinary; D004195:Disease Models, Animal; D005260:Female; D005753:Gastric Mucosa / Q000473:pathology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000502:physiology*; D010437:Peptic Ulcer / Q000209:etiology; D013272:Stomach Diseases / Q000473:pathology / Q000662:veterinary*; D013312:Stress, Physiological / Q000150:complications