Effects of giving ethionine on the parathion-metabolizing enzymes in the liver of fasted calves.
DL-Ethionine (0.87 g/kg) or saline solution (equivalent volume) was administered IV to 4-month-old calves which had been fasted 60 hours before slaughter. The livers of the ethionine-treated calves were large, had a high lipid content, and were diffusely pale yellow on the cut surface. The livers of the saline-treated group were shrunken. In liver samples from calves of both groups, there was reduced parathion and paraoxon metabolism. In the ethionine-treated group, parathion desulfuration also was reduced. In all cases, the changes were greater in the ethionine-treated animals. Fasting of calves with saline solution or ethionine treatment caused a lowering of the liver biotransformation of parathion and paraoxon.
D000818:Animals; D001711:Biotransformation; D002417:Cattle / Q000378:metabolism*; D005001:Ethionine / Q000494:pharmacology*; D005215:Fasting / Q000662:veterinary*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D010261:Paraoxon / Q000378:metabolism; D010278:Parathion / Q000378:metabolism*
D010278:Parathion; D010261:Paraoxon; D005001:Ethionine