title: Isotype-specific measurement of rheumatoid factor with reference to clinical features of rheumatoid arthritis.
abstract: Serum levels of IgG, IgA and IgM rheumatoid factor (IgG RF, IgA RF and IgM RF) were estimated by means of the diffusion-in-gel enzyme-linked immunosorbent assay (DIG-ELISA), in 90 Waaler-Rose positive and Waaler-Rose negative rheumatoid arthritis (RA) patients as well as in 60 controls. The presence of IgG and/or IgA RF was shown to be of high predictive value concerning the occurrence of systemic manifestations in RA. All RF isotypes measured were good indicators of the disease activity.
mesh_terms: D000328:Adult; D000368:Aged; D000918:Antibody Specificity; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D012217:Rheumatoid Factor / Q000032:analysis*
chemical_list: D007070:Immunoglobulin A; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012217:Rheumatoid Factor