Synthesis and pharmacological investigations of derivatives 6-azabenzodiazepines.
Acylated derivatives 4-6 of 2-aminomethylene-4-phenyl-1H-tetrahydro-6-azabenzo-1,5-diazepine 3, and carbonyl derivatives 7-10 of 6-azabenzo-1,5-diazepines were obtained. They did not display any particular pharmacological activity in screening tests: 2 exerted a weak hypotensive action and 8 possessed negligible anticonvulsant properties.
D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D001921:Brain / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006801:Humans; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010830:Physostigmine / Q000037:antagonists & inhibitors; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors; D013239:Stereotyped Behavior / Q000187:drug effects
D000927:Anticonvulsants; D001569:Benzodiazepines; D012110:Reserpine; D010830:Physostigmine