[Effect of the combined action of metronidazole and cycloheximide on protein synthesis and tumor regression following irradiation].
A radiosensitizing effect of metronidazole on a tumor was enhanced by a small dose of cycloheximide. Metronidazole caused a considerable inhibition of the protein synthesis during the first six hours following irradiation. Cycloheximide, in the dose used, did not enhance the effect of metronidazole on the postirradiation protein synthesis.
D000818:Animals; D003131:Combined Modality Therapy; D003513:Cycloheximide / Q000008:administration & dosage*; D005260:Female; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000378:metabolism / Q000532:radiotherapy*; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage*; D051381:Rats
D009363:Neoplasm Proteins; D011838:Radiation-Sensitizing Agents; D008795:Metronidazole; D003513:Cycloheximide
Vliianie kombinirovannogo deĭstviia metronidazola i tsiklogeksimida na sintez belka i regressiiu opukholi posle oblucheniia.