A new antitumor antibiotic, awamycin.
A new antibiotic, awamycin, was isolated from the culture broth of Streptomyces sp. No. 80-217. It appeared to belong to the quinone indicator group from results of physicochemical studies and has the empirical formula C38H49NO12S. This antibiotic possessed antibacterial and antitumor activities against Gram-positive bacteria and experimental murine tumors. The antibiotic also showed direct cytotoxic activity against HeLa cells in vitro.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification*; D002277:Carcinoma / Q000188:drug therapy; D005285:Fermentation; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D011809:Quinones / Q000302:isolation & purification / Q000627:therapeutic use; D012510:Sarcoma 180 / Q000188:drug therapy; D013302:Streptomyces / Q000254:growth & development* / Q000648:ultrastructure
D000903:Antibiotics, Antineoplastic; D011809:Quinones; C039621:awamycin