[Effect of testosterone propionate on the induction by 1,2-dimethylhydrazine of angiosarcomas of the renal capsule in castrated mice].
Administration of 1,2-dimethylhydrazine (DMH) produced 83% (15/18) of renal capsule angiosarcomas in CBA mice. Castration that preceded the DMH-treatment reduced tumor incidence to 7% (2/29). Simultaneous administration of DMH and testosterone propionate (TP) to castrated males restored the tumor frequency (100%, 24/24). Castrated males that received TP after the cessation of the DMH treatment developed tumors in 10% (3/31). Combined treatment of castrated females with DMH and TP resulted in the development of angiosarcomas in 92% animals (22/24). It is concluded that TP enhances the stage of sarcomogenesis initiation induced by DMH.
D000818:Animals; D002369:Castration; D004127:Dimethylhydrazines / Q000494:pharmacology*; D005260:Female; D006394:Hemangiosarcoma / Q000139:chemically induced*; D007680:Kidney Neoplasms / Q000139:chemically induced*; D008297:Male; D008763:Methylhydrazines / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010053:Ovary / Q000502:physiology*; D013268:Stimulation, Chemical; D013737:Testis / Q000502:physiology*; D013739:Testosterone / Q000494:pharmacology*; D013997:Time Factors
D004127:Dimethylhydrazines; D008763:Methylhydrazines; D013739:Testosterone
Vliianie testosterona propionata na induktsiiu 1,2-dimetilgidrazinom angiosarkom pochechnoĭ kapsuly u kastrirovannykh mysheĭ.