title: Behavioural examinations of the anti-aggressive drug fluprazine.
abstract: The behavioural influence of the anti-aggressive drug Fluprazine (DU 27716) was examined using an ethological technique. The drug inhibited aggressive behaviour but not in an entirely specific way. Fluprazine also stimulated non-social and defensive/flight behaviours; there was a greater tendency for drug-treated animals to avoid their opponents. Using an automatic recording technique the drug's anti-aggressive action was monitored for 23 h. There was a potent anti-aggressive influence that lasted for up to 4 h. However, when the drug-effect wore off there were bouts of fighting. Over 23 h Fluprazine did not significantly decrease the total aggression recorded.
mesh_terms: D000374:Aggression / Q000187:drug effects*; D000378:Agonistic Behavior / Q000187:drug effects; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D009115:Muridae; D010879:Piperazines / Q000494:pharmacology*; D012919:Social Behavior
chemical_list: D010879:Piperazines; C035521:fluprazine