Synthesis and biological evaluation of a 4-fluoromethyl monobactam analog.
The synthesis and in vitro antibacterial activity of (+/-)(cis)-3-[2-(2-aminothiazol-4-yl)-(Z)-2-methoxyiminoacetamido]- 4-fluoromethyl-2-oxo-1-azetidinesulfonic acid, potassium salt are presented.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000633:toxicity; D001398:Aztreonam; D006090:Gram-Negative Bacteria / Q000187:drug effects; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared
D000900:Anti-Bacterial Agents; D007202:Indicators and Reagents; D001398:Aztreonam