Voltage-dependent block by histrionicotoxin of the acetylcholine-induced current in an insect motoneurone cell body.
Acetylcholine (ACh)-induced currents were recorded from the voltage-clamped cell body of the fast coxal depressor motoneurone of the cockroach Periplaneta americana, at membrane potentials in the range -120 mV to -60 mV. In the presence of histrionicotoxin (HTX) (1.0 X 10(-6) M), ACh currents were blocked. The blocking action of HTX was voltage-dependent, being more effective at more negative membrane potentials.
D000109:Acetylcholine / Q000494:pharmacology*; D000664:Amphibian Venoms / Q000633:toxicity*; D000818:Animals; D003058:Cockroaches; D004553:Electric Conductivity; D008564:Membrane Potentials / Q000187:drug effects; D009046:Motor Neurons / Q000187:drug effects / Q000502:physiology*; D011978:Receptors, Nicotinic / Q000502:physiology
D000664:Amphibian Venoms; D011978:Receptors, Nicotinic; D000109:Acetylcholine; C007948:histrionicotoxin