[Effect of remantadine on the course of influenzal infection in immunosuppressed mice].
The results of the study on the influence of remantadine on the course of experimental influenza infection in mice with immunity suppressed by cyclophosphamide are presented. Mice treated with cyclophosphamide were shown to have a more severe course of influenza infection. Remantadine, as an effective chemotherapeutic drug, decreased mortality rates in all the treated groups of the animals.
D000218:Adamantane / Q000031:analogs & derivatives*; D000818:Animals; D002642:Chick Embryo; D003520:Cyclophosphamide / Q000276:immunology; D004353:Drug Evaluation, Preclinical; D007108:Immune Tolerance / Q000187:drug effects*; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000276:immunology / Q000401:mortality; D012299:Rimantadine / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
D012299:Rimantadine; D003520:Cyclophosphamide; D000218:Adamantane
Vliianie remantadina na techenie grippoznoĭ infektsii u immunodepressirovannykh mysheĭ.