Estimation of the elimination half-life of the monoamine oxidase inhibitor cimoxatone in rat brain on the basis of ex vivo inhibition data.
Cimoxatone is a reversible mixed-type selective inhibitor of monoamine oxidase-A. For a mixed-type inhibitor, it can be shown that (vo-vi)/Vi is proportional to the inhibitor concentration. This relationship has been used to estimate the t 1/2 of the elimination of cimoxatone in rat brain after a single dose of inhibitor. t 1/2 values, estimated with three monoamine oxidase substrates, were in the range 3.9-4.8 h, in reasonable agreement with t 1/2 values determined from the plasma and brain concentration/time curves of cimoxatone.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D006207:Half-Life; D066298:In Vitro Techniques; D008297:Male; D008657:Metabolic Clearance Rate; D008995:Monoamine Oxidase / Q000378:metabolism; D008996:Monoamine Oxidase Inhibitors / Q000378:metabolism*; D010080:Oxazoles / Q000378:metabolism*; D023303:Oxazolidinones; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin
D008996:Monoamine Oxidase Inhibitors; D010080:Oxazoles; D023303:Oxazolidinones; D012701:Serotonin; D008995:Monoamine Oxidase; C026234:cimoxatone