Effect of exposure to high concentrations of toluene on ethanol preference of laboratory rats.
Male and female Holtzman Sprague Dawley rats were given 10-minute exposures to high concentrations of toluene twice a week at 10-30 days of age. The rate of acquisition of ethanol preference for these rats did not differ significantly from litter-mate sham exposed controls. Once ethanol preference curves were established, the rats were exposed daily over a 5-day period to high concentrations of toluene. An increase in ethanol intake occurred in most of the rats irrespective of early toluene exposures at 10-30 days of age.
D000437:Alcoholism / Q000150:complications*; D000818:Animals; D004347:Drug Interactions; D000431:Ethanol / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D019966:Substance-Related Disorders / Q000150:complications*; D014050:Toluene / Q000008:administration & dosage
D014050:Toluene; D000431:Ethanol