Ketone bodies in cold-acclimated rats.
Acclimation temperature (28 or 5 degrees C) modifies acetoacetate (AA) and beta-hydroxybutyrate (BOH) levels in blood and liver. In the fed state AA and BOH levels were increased in blood and liver of 5 degrees C adapted rats. In the fasting state (24 or 48 hr) an antiketotic action of cold acclimation was observed. It was found to be more pronounced with high fat diet. These effects were more marked in the blood than in the liver. The variations in ketonemia are discussed with relation to the role of liver in cold adapted rats.
D020155:3-Hydroxybutyric Acid; D000064:Acclimatization / Q000187:drug effects; D000090:Acetoacetates / Q000097:blood* / Q000378:metabolism; D000818:Animals; D003080:Cold Temperature; D004041:Dietary Fats / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006885:Hydroxybutyrates / Q000097:blood* / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D013217:Starvation / Q000378:metabolism
D000090:Acetoacetates; D004041:Dietary Fats; D005230:Fatty Acids, Nonesterified; D006885:Hydroxybutyrates; C016635:acetoacetic acid; D020155:3-Hydroxybutyric Acid