Combined pharmacokinetic and pharmacodynamic study of a single bolus dose of atracurium.
Simultaneous pharmacokinetic and pharmacodynamic measurements were made in six patients following atracurium 0.3 mg kg-1. Good correlation between plasma concentration and response for all patients gave an EC50 of 0.29 +/- 0.04 (SD) microgram ml-1 and a Hill coefficient of 4.6 +/- 0.5 (SD).
D000328:Adult; D000368:Aged; D001279:Atracurium; D006221:Halothane; D006801:Humans; D007275:Injections, Intravenous; D007546:Isoquinolines / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology; D007700:Kinetics; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage / Q000097:blood*
D007546:Isoquinolines; D009466:Neuromuscular Blocking Agents; D001279:Atracurium; D006221:Halothane