Establishment of a murine cell line resistant to arabinosyladenine and devoid of adenosine deaminase activity.
A population of cells stably resistant to a concentration of arabinosyladenine 100-fold greater than that tolerated by wild-type cells was selected over a period of 15 months. The cells are not cross resistant to arabinosylcytosine and may have at least one kinase with altered substrate specificity.
D000243:Adenosine Deaminase / Q000378:metabolism*; D000818:Animals; D002460:Cell Line; D002999:Clone Cells / Q000187:drug effects; D003561:Cytarabine / Q000494:pharmacology; D004351:Drug Resistance; D051379:Mice; D009700:Nucleoside Deaminases / Q000378:metabolism*; D014740:Vidarabine / Q000494:pharmacology*
D003561:Cytarabine; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase; D014740:Vidarabine