[Effect of olivomycin on the microsomal oxidation enzymes, the mitochondria and the protein-synthesizing apparatus of the rat liver in acute tetrachloromethane poisoning].
Influence of olivomycin an inhibitor of protein biosynthesis on the enzymes of microsomal oxidation, bioenergetic processes in mitochondria and the polyribosomal profile in liver of rats intoxicated with tetrachloromethane was studied. It was established that the pretreatment of rats with olivomycin protected the hepatocytes from the effect of tetrachloromethane, reducing the hyperenzymaemia, hyperbilirubinemia, the degree of mitochondrial enzymes inhibition and the destruction of polyribosomes. Administration of olivomycin to healthy animals diminished the cytochrome P-450 content and led to slight changes of polyribosomal profile. Possible mechanisms of the protective effects of olivomycin under conditions of acute hepatic injury are discussed.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology*; D003577:Cytochrome P-450 Enzyme System / Q000097:blood; D004721:Endoplasmic Reticulum / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology*; D009848:Olivomycins / Q000494:pharmacology*; D051381:Rats; D012270:Ribosomes / Q000187:drug effects / Q000201:enzymology*
D009848:Olivomycins; D003577:Cytochrome P-450 Enzyme System; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D001663:Bilirubin
Vliianie olivomitsina na fermenty mikrosomnogo okisleniia, mitokhondriĭ i beloksinteziruiushchiĭ apparat pecheni krys pri ostroĭ intoksikatsii tetrakhlormetanom.