Investigation of new benzofurane, benzopiran and furanochromone derivatives--potential antiarrhythmic and hypotensive agents.
Eight newly synthesized compounds were tested in respect of their acute toxicity, antiarrhythmic activity, influence on the electrogenic action of the heart and blood pressure. The most active benzofuran derivative was 2-acetyl-3-methyl-6 methoxy-7-(2'hydroxy-3'-isopropylaminopropoxy)benzofuran, the most active benzopiran: 4-methyl-6,7-dimethoxy-8-(2'-isopropylaminopropoxy)benzo-alpha- piron. Of furachromone derivatives the expected properties were displayed only by 2-methyl-5-carbamoylmethoxy-8-diisopropylaminofuro-3,2-g-chr omone.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001572:Benzofurans / Q000494:pharmacology* / Q000633:toxicity; D001578:Benzopyrans / Q000494:pharmacology* / Q000633:toxicity; D001794:Blood Pressure / Q000187:drug effects; D002867:Chromones / Q000494:pharmacology*; D004562:Electrocardiography; D008297:Male; D051379:Mice; D051381:Rats; D013329:Structure-Activity Relationship
D000889:Anti-Arrhythmia Agents; D000959:Antihypertensive Agents; D001572:Benzofurans; D001578:Benzopyrans; D002867:Chromones