Atracurium during halothane anesthesia in humans.
The neuromuscular effects of atracurium were studied in 20 patients anesthetized with 0.8% end-tidal halothane. Neuromuscular blockade was monitored by recording the electromyographic activity of the adductor pollicis muscle resulting from stimulation of the ulnar nerve. Four groups of five patients received single atracurium doses of 0.1, 0.15, 0.2, or 0.4 mg/kg, respectively. The block produced by 0.1 mg/kg was 25-72% and lasted 6-21 min. The block produced by 0.15 mg/kg was 69-93% and lasted 16-32 min. The blocks produced by 0.2 and 0.4 mg/kg were 95% or greater and lasted 42-84 min and 55-104 min, respectively. When indicated, intubation was easily performed in all patients receiving 0.2 and 0.4 mg/kg. The block could be readily antagonized by neostigmine and atropine. Changes in heart rate and blood pressure following atracurium administration averaged less than 5%.
D000293:Adolescent; D000328:Adult; D001279:Atracurium; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004576:Electromyography; D006221:Halothane / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007442:Intubation, Intratracheal / Q000379:methods; D007546:Isoquinolines / Q000009:adverse effects / Q000494:pharmacology*; D008875:Middle Aged; D009407:Nerve Block; D009469:Neuromuscular Junction / Q000187:drug effects*
D007546:Isoquinolines; D001279:Atracurium; D006221:Halothane