Thyrotropin effects on vesicle transfer and thyroid follicle morphogenesis: a stereological study in the rat.
Incubation in a culture medium with and without TSH of 16 day-old foetal thyroid glands induces hypertrophy of the Golgi apparatus which may be correlated with a considerable increase in the number of secretory vesicles. A stereological study performed during the first 6 hr of incubation showed that: vesicle secretion was biphasic; vesicle secretion was heterogeneous with two different populations of vesicles; When TSH (20 mU and 80 mU) was added to the medium, the volume density of the follicular lumina increased; at least during the first 6 hr TSH seemed to be necessary to the formation of follicular lumina.
D000818:Animals; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D005333:Fetus; D006056:Golgi Apparatus / Q000648:ultrastructure; D066298:In Vitro Techniques; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure; D013972:Thyrotropin / Q000494:pharmacology*
D013972:Thyrotropin