title: Anthelmintic activity of ivermectin in pigs naturally infected with Ascaris and Trichuris.
abstract: The anthelmintic efficacy of ivermectin administered by subcutaneous (SC) injection or orally via the drinking water was investigated in feeder pigs naturally infected with Ascaris suum and Trichuris suis. Group 1 pigs (n = 5) were given drinking water as a placebo, group 2 pigs (n = 5) were given ivermectin by SC injection (300 micrograms/kg of body weight), and group 3 pigs (n = 5) were given ivermectin in water also at a dosage rate of 300 micrograms/kg of body weight. At necropsy 11 days later, the mean worm counts in group 1 pigs were 4 for Ascaris and 50.2 for Trichuris. All adult and juvenile ascarids were removed from the intestine in groups 2 and 3 pigs. Compared with the number of Trichuris in group 1 pigs, the number of Trichuris was reduced by 91.2% and 78.1%, respectively, for the orally and SC treated pigs.
mesh_terms: D000818:Animals; D000871:Anthelmintics; D001196:Ascariasis / Q000188:drug therapy*; D001200:Ascaris; D005260:Female; D007559:Ivermectin; D007783:Lactones / Q000627:therapeutic use*; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy*; D014257:Trichuriasis / Q000188:drug therapy*; D014258:Trichuris
chemical_list: D000871:Anthelmintics; D007783:Lactones; D007559:Ivermectin