[Effect of hydrocortisone on the frequency and inheritance of the fused gene in mice].
The influence of hydrocortisone injections given to males on the penetrance and inheritance of fused gene in mice was studied. The existence of a period sensitive to hydrocortisone action was found. The treatment of males during this interval led to a significant decrease in the proportion of offsprings with fused phenotype. Genetic analysis by means of the closely linked recessive tufted marker permitted to show that the lack of phenotypically fused mice is not due to differential mortality of gametes, zygotes or embryos. The most probable reason for this lack is the decrease in penetrance and partially inherited inactivation of fused gene. Possible mechanisms of the phenomenon found are discussed.
D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D005787:Gene Frequency / Q000187:drug effects*; D005796:Genes / Q000187:drug effects*; D005838:Genotype; D006824:Hybridization, Genetic; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010641:Phenotype; D013091:Spermatogenesis / Q000187:drug effects
D006854:Hydrocortisone
Vliianie gidrokortizona na proiavlenie i nasledovanie gena fused u mysheĭ.