[Single cell photometry analysis of nuclear DNA in treated undifferentiated prostate cancer and its clinical significance].
Based on 67 specimens from 20 conservatively treated undifferentiated prostate cancer patients cell nucleic acid analysis combined with a prospective clinical study was attempted using single cell scanning-cytophotometry. Regardless of therapy type a statistically significant difference in nuclear DNA-content was evident between successfully treated prostate cancers and therapy-resistant cancers. Good prognosis was suggested by a significant decline from aneuploid or polyploid to diploid nuclear-DNA-content with a narrow peak in 2c, especially within the first 12 weeks of treatment. Lack of DNA-content alteration or a DNA-frequency distribution change to the right were correlated with rapid clinical regression. Although all had undifferentiated prostate cancer morphology statistically significant differences in nuclear DNA-content were found. The prognostic value of this remains unknown.
D004273:DNA, Neoplasm / Q000032:analysis*; D006801:Humans; D008297:Male; D010783:Photometry; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000032:analysis* / Q000188:drug therapy
D004273:DNA, Neoplasm
Einzelzellzytophotometrische Zellkern-DNS-Analysen beim behandelten, entdifferenzierten Prostatakarzinom und ihre klinische Bedeutung.