Influence of ethosuximide on metrazol-induced seizures during ontogenesis in rats.
Effects of metrazol (pentylenetetrazole and ethosuximide were studied in male albino rats aged 7, 12, 18 and 90 days. The 18-day-old rats exhibited the highest sensitivity to metrazol. CD50s in the remaining three age groups were nearly the same. Ethosuximide was reliably effective against metrazol only in adult rats; in young animals it did not significantly change CD50s. Metrazol induced in ethosuximide-pretreated young rats either modified (long-lasting minimal seizures in 18-day-old animals) or new seizure patterns (minimal seizures in 7- and 12-day-old rats).
D000375:Aging; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005013:Ethosuximide / Q000494:pharmacology*; D008297:Male; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced* / Q000517:prevention & control
D005013:Ethosuximide; D010433:Pentylenetetrazole