Immunologic abnormalities in idiopathic Raynaud's phenomenon.
Sera from 14 patients with idiopathic Raynaud's phenomenon were studied for immunoglobulin levels, autoantibodies and circulating immune complexes. In addition, the levels of immune complexes were studied in 17 sera from patients with secondary Raynaud's phenomenon. It was found that more than one half of the patients with idiopathic Raynaud's phenomenon have serologic markers of auto-immune disease. The incidence of circulating immune complexes was higher in patients with secondary (52%) compared to patients with idiopathic Raynaud's phenomenon (10%). The serologic abnormalities in idiopathic Raynaud's phenomenon patients did not correlate with asymptomatic pulmonary involvement.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000276:immunology; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011928:Raynaud Disease / Q000276:immunology*
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M