title: Immune exclusion, a mechanism of protection against the ovine nematode Haemonchus contortus.
abstract: The fate of exsheathed Haemonchus contortus larvae injected directly into the abomasal lumen was studied in groups of naive and hyperimmune sheep. Within 48 hours of challenge, more than 90 per cent of the larvae were lost from hyperimmune sheep. The larvae had a propensity to associate with the superficial mucus in both groups and, in naive sheep, approximately 50 per cent of the larvae entered glandular tissue within four hours of challenge. By contrast, although initially associated with the mucosal surface, larvae in immune sheep were excluded from the glandular tissues. It is postulated that the rapid loss of worms from the hyperimmune abomasum is a consequence of 'immune exclusion' and the possible mechanisms underlying this process are discussed.
mesh_terms: D000018:Abomasum / Q000473:pathology; D000818:Animals; D005243:Feces / Q000469:parasitology; D005260:Female; D006188:Haemonchiasis / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D008297:Male; D010270:Parasite Egg Count; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology* / Q000469:parasitology; D014252:Trichostrongyloidiasis / Q000662:veterinary*