title: [Tumor regression following local chemotherapy in carcinomas of the upper respiratory and digestive tracts. The viewpoint of the pathologist].
abstract: Few pathologists have given much thought to the problem of post-chemotherapeutic tumoral regression of upper respiratory and digestive tract carcinoma. In other oncological fields (pediatry: nephroblastoma, embryonic sarcoma, osteosarcoma; gynecology: mammary tumors...) pre- and post-chemotherapy tissue studies have led to histological grading of prognostic value (particularly well known is that of Rosen et al). Numerous specimens were examined following operations for cancer, including pelvimandibulectomy, buccopharyngectomy, facial resection... Possible tumoral changes were evaluated using a conventional scale of regression based on 6 histologic degrees, and findings were of prognostic significance when compared with the initial biopsy results. This evaluation scale may require modification in the near future since recently introduced chemotherapy, particularly cisplatinum, appears to have a more potent and more specific effect on histologie features.
mesh_terms: D002277:Carcinoma / Q000188:drug therapy / Q000473:pathology; D004067:Digestive System Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008207:Lymphatic Metastasis; D012142:Respiratory Tract Neoplasms / Q000188:drug therapy* / Q000473:pathology
vernacular_title: La régression tumorale après chimiothérapie locale dans les carcinomes des voies aéro-digestives supérieures. Le point de vue du pathologiste.