title: Absorption and disposition of ibuprofen in hemodialyzed uremic patients.
abstract: The absorption and disposition of ibuprofen was investigated in seven hemodialyzed uremic patients. Ibuprofen (400 mg) was orally administered to each patient 1 hr or 4 hr prior to hemodialysis. Uremic patients appeared to absorb ibuprofen at a slower rate as compared to normal subjects. The hemodialysis systems used in this study yielded a mean extraction efficiency of 16.7% for ibuprofen, with a mean dialysis plasma clearance of 22.7 ml/min. The drug recovery resulting from hemodialysis represented a small fraction of the ingested dose of ibuprofen (less than 4%). The half-life of ibuprofen (1.3-1.9 hr) was not significantly altered by hemodialysis. Observations of extraction efficiency, drug recovery and half-life during dialysis suggested nondialyzability of ibuprofen, probably due to its extensive protein binding (approximately 90%). Uremic patients may require a comparatively longer time to achieve the therapeutic concentration attained in normal volunteers. However, dosage adjustment is not required once a regimen is implemented in uremia.
mesh_terms: D000042:Absorption; D000328:Adult; D001158:Arteries; D006207:Half-Life; D006801:Humans; D007052:Ibuprofen / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D014462:Ultrafiltration; D014511:Uremia / Q000378:metabolism* / Q000628:therapy; D014680:Veins
chemical_list: D007052:Ibuprofen