title: Phenol solutions differentially block conduction in cutaneous nerve fibers of the cat.
abstract: The action of phenol in Tyrode solution on nerve conduction has been investigated in vivo in the desheathed sural nerve of cats. A section of 8 mm of the nerve was exposed to phenol solution. At low phenol concentrations (0.05-0.125%) a reversible block of A- and C-fibers occurred. At higher concentrations (0.6-1%) a selective and persistent C-fiber block could be achieved. The size of the residual A-volley was between 50% and 81% when all C-fibers were blocked.
mesh_terms: D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D009412:Nerve Fibers / Q000187:drug effects; D009431:Neural Conduction / Q000187:drug effects*; D019800:Phenol; D010636:Phenols / Q000494:pharmacology*; D013127:Spinal Nerves / Q000187:drug effects*; D013497:Sural Nerve / Q000187:drug effects*
chemical_list: D010636:Phenols; D019800:Phenol