Efficacy of mono- and bis-pyridinium oximes versus soman, sarin and tabun poisoning in mice.
Various oximes (PAM, toxogonin, TMB-4, HS-6, HI-6, HGG-12, HGG-42) combined with atropine were compared as antidotes of soman, sarin and tabun poisoning in non-fasted CD-1 male mice. TMB-4 was the most toxic oxime with an i.p. LD50 value of 80 mg/kg and HI-6 was the least toxic oxime with an i.p. LD50 of 588 mg/kg. Upon comparing ED50 values, HGG-42 was the most effective oxime versus soman and tabun poisoning whereas, HI-6 was the most effective oxime versus sarin poisoning. Further research needs to be done to explain the distinct differences in efficacy of the oximes versus poisoning by soman, sarin or tabun.
D000818:Animals; D000931:Antidotes / Q000494:pharmacology* / Q000633:toxicity; D002800:Cholinesterase Inhibitors / Q000506:poisoning*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D062025:Organophosphate Poisoning; D010755:Organophosphates; D010091:Oximes / Q000494:pharmacology* / Q000633:toxicity; D011726:Pyridinium Compounds / Q000494:pharmacology* / Q000633:toxicity; D012524:Sarin / Q000506:poisoning*; D012999:Soman / Q000506:poisoning*; D013329:Structure-Activity Relationship
D000931:Antidotes; D002800:Cholinesterase Inhibitors; D010755:Organophosphates; D010091:Oximes; D011726:Pyridinium Compounds; D012999:Soman; D012524:Sarin; C009374:tabun