Lectin resistance and lectin binding in a rat adenocarcinoma.
Cell cultures from the R3230 AC rat mammary adenocarcinoma, when injected i.v. into F 344 rats, invariably produce multiple lung foci within 10 days. We compared the colonization potential of cultures exposed to 100 micrograms/ml medium of both Concanavalin A and Wheat Germ Agglutinin for 5 passages with the original cell line. All cell lines retained their ability to bind both lectins and to grow after subcutaneous implant; however, the lectin resistant after subcutaneous implant; however, the lectin resistant variant was found to have completely lost its capacity to nidate in the lung.
D000230:Adenocarcinoma / Q000378:metabolism* / Q000556:secondary; D000818:Animals; D002460:Cell Line; D003208:Concanavalin A / Q000494:pharmacology; D004351:Drug Resistance; D005260:Female; D037102:Lectins / Q000494:pharmacology; D008175:Lung Neoplasms / Q000556:secondary; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D014909:Wheat Germ Agglutinins
D037102:Lectins; D014909:Wheat Germ Agglutinins; D003208:Concanavalin A