Acquired B antigen and polyagglutination in a patient with gastric cancer.
Erythrocytes from a patient with blood type of A1 became nongenetically reactive with A (anti-B) serum, following the development of gastric cancer. Transient polyagglutinability was also apparent. The in vitro acetylation of the erythrocyte antigens abolished both the acquired B antigen and the polyagglutination. Although incubation of the heterologous type A1 erythrocytes with the patient's serum did not produce B antigen, deacetylase activity in the serum seems to relate to the acquired B antigen. In this case, either ileus as a result of metastatic adenocarcinoma of the stomach, or urinary tract infections could be the cause of the acquired B antigen.
D000017:ABO Blood-Group System / Q000276:immunology*; D000107:Acetylation; D000230:Adenocarcinoma / Q000276:immunology*; D000581:Amidohydrolases / Q000097:blood; D005260:Female; D006384:Hemagglutination; D006801:Humans; D007415:Intestinal Obstruction / Q000209:etiology; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000276:immunology*; D014552:Urinary Tract Infections / Q000150:complications
D000017:ABO Blood-Group System; D000581:Amidohydrolases