Urinary excretion products after the administration of 14C-acetaldehyde to rats.
Rats were injected with 120 micro Ci of 14C-acetaldehyde containing carrier acetaldehyde, and the urinary excretion products were assayed by cation exchange chromatography, resolving five main peaks of radioactivity. Urine contained 6% of the dose of 14C-acetaldehyde administered. The main urinary product of acetaldehyde, fraction 5, was produced via acetate. Acetate was also identified in the urine. Two cysteine adducts, probably isomeric metabolites of 2-methylthiazolidine-4-carboxylic acid, were detected. They constituted about 2% of the radioactivity in the urine collected 48 h after the administration of 14C-acetaldehyde. They appeared to retain a carboxylic group. When the reaction mixture of 14C-cysteine and acetaldehyde was injected into a rat, the half-lives of the two tiazolidine derivatives was 10 h. Only 13.6% of the radioactivity was detected in the urine suggesting ready metabolism of 2-methylthiazolidine-4-carboxylic acid.
D000079:Acetaldehyde / Q000652:urine*; D000818:Animals; D001711:Biotransformation; D002250:Carbon Radioisotopes; D002852:Chromatography, Ion Exchange; D003545:Cysteine / Q000652:urine*; D006207:Half-Life; D007536:Isomerism; D051381:Rats; D011919:Rats, Inbred Strains
D002250:Carbon Radioisotopes; D000079:Acetaldehyde; D003545:Cysteine