Flicker sensitivity changes after subcortical visual system lesions in the rat.
Sensitivity to sinusoidal flicker, as a function of flicker frequency, was measured behaviourally in hooded rats by reducing modulation depth in a two-choice flicker versus no-flicker discrimination until subjects could not perform at above 80% correct. Analogous methods were used to measure spatial contrast sensitivity. In both tasks the display area was 24 x 20 degrees. Bilateral lesions were made in one of 4 structures; superior colliculus (SC), pretectum (PRT), posterior thalamus (PT), or ventral lateral geniculate nucleus (LGv). A fifth group served as sham operated controls. On the basis of histology the LGv group was subdivided according to presence or absence of optic tract damage. PT, PRT and LGv lesions produced a statistically significant depression in flicker sensitivity, the impairment in the LGv sub-group with optic tract damage being significantly greater than that in the LGv group with optic tract sparing. In the latter, post-operative sensitivity correlated significantly with amount of surviving tissue in the thalamic radiations but not with surviving LGv itself. PRT and LGv lesions that involved the optic tract also significantly depressed spatial contract sensitivity. The implications of the finding, that PT and LGv lesions may depress flicker sensitivity without affecting spatial vision, for interpretation of the effects of comparable lesions on suprathreshold discrimination are discussed.
D000818:Animals; D001931:Brain Mapping; D004193:Discrimination Learning / Q000502:physiology; D005074:Evoked Potentials, Visual; D005425:Flicker Fusion / Q000502:physiology*; D005829:Geniculate Bodies / Q000502:physiology; D008297:Male; D009115:Muridae; D009900:Optic Nerve / Q000502:physiology; D012684:Sensory Thresholds; D013477:Superior Colliculi / Q000502:physiology; D013787:Thalamic Nuclei / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology; D014795:Visual Pathways / Q000502:physiology*