title: Metabolic factors and preference for ethanol.
abstract: Alcohol intoxication diminishes the metabolic differences between ethanol- and water-preferring rats in the levels of free amino acids (liver, brain, blood plasma), lipid fractions (liver), the activities of glucokinase (liver), and aldehyde dehydrogenase (brain), and the content of glucose-6-phosphate and prostaglandins (liver). The action of alcohol is discussed as that directed to the partial elimination of biochemical individuality, thus simplifying the regulation of metabolism in the living system. In this connection preferential ethanol consumption may be regarded as a biological mode of self-correction.
mesh_terms: D000079:Acetaldehyde / Q000378:metabolism*; D000428:Alcohol Drinking; D000435:Alcoholic Intoxication / Q000201:enzymology; D000444:Aldehyde Dehydrogenase; D000445:Aldehyde Oxidoreductases / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002755:Choice Behavior / Q000502:physiology*; D004734:Energy Metabolism / Q000187:drug effects*; D000431:Ethanol / Q000378:metabolism*; D005941:Glucokinase / Q000378:metabolism; D019298:Glucose-6-Phosphate; D005958:Glucosephosphates / Q000378:metabolism; D006801:Humans; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D011453:Prostaglandins / Q000378:metabolism; D051381:Rats
chemical_list: D000596:Amino Acids; D005958:Glucosephosphates; D011453:Prostaglandins; D000431:Ethanol; D019298:Glucose-6-Phosphate; D000445:Aldehyde Oxidoreductases; D000444:Aldehyde Dehydrogenase; D005941:Glucokinase; D000079:Acetaldehyde