title: Evidence of beneficial effects of strict glycemic control on diabetic vascular complications--a prospective study with artificial devices.
abstract: This prospective study was undertaken to examine whether glycemic normalization could have beneficial on the course of diabetic vascular complications in 6 insulin-dependent diabetics. A significant amelioration of glycemic regulation was achieved by intensive glycemic control with artificial devices and multiple injections for 3 months, which also resulted in an improvement in conduction velocity, a regression in retinovascular permeability and a decrease in urinary total protein excretion. These results indicate that even after short-term treatment, glycemic near-normalization can have a beneficial effect on the early stage of diabetic vascular complications.
mesh_terms: D001786:Blood Glucose / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000188:drug therapy; D003925:Diabetic Angiopathies / Q000188:drug therapy*; D003930:Diabetic Retinopathy / Q000188:drug therapy; D005260:Female; D006801:Humans; D007332:Insulin Infusion Systems; D008297:Male; D011446:Prospective Studies
chemical_list: D001786:Blood Glucose