Effects of dietary protein on the pharmacokinetics of butylated hydroxytoluene (BHT) in rats.
The effects of dietary protein on the metabolism of butylated hydroxytoluene (BHT) were examined in the present study by comparison of the pharmacokinetics of BHT in rats fed different levels of dietary protein. Groups of young female rats were fed diets containing 24%, 8%, or 4% protein, as supplied from casein, for 4 weeks. At the end of the feeding period, a single oral dose of 500 mg BHT/kg was administered intragastrically to each rat. The serum BHT concentration was then measured at intervals during the first 12 hr following BHT administration. Several kinetic measurements were obtained from both the zero-order and first-order plots of serum BHT concentration versus time. Reduced BHT metabolism as indicated by increased concentration and delayed clearance of BHT in the circulation was found among rats fed 4% dietary protein compared to those fed 24% protein. On the other hand, no significant alteration was observed in any of the kinetic parameters obtained from rats fed 8% dietary protein. It was concluded that metabolism of BHT is reduced only when protein consumption is reduced to a 4% dietary level.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002084:Butylated Hydroxytoluene / Q000378:metabolism*; D004032:Diet; D004044:Dietary Proteins / Q000494:pharmacology*; D005260:Female; D006207:Half-Life; D007700:Kinetics; D051381:Rats
D004044:Dietary Proteins; D002084:Butylated Hydroxytoluene