Anxiogenic action of a convulsant benzodiazepine: reversal by chlordiazepoxide.
Ro5-3663, a convulsant benzodiazepine and a ligand for CNS picrotoxin sites, but not for benzodiazepine sites, had a significant dose-related (2 and 4 mg/kg) anxiogenic action in the social interaction test of anxiety. This anxiogenic effect was reversed by chlordiazepoxide (5 mg/kg).
D000818:Animals; D001007:Anxiety / Q000187:drug effects*; D001569:Benzodiazepines / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000494:pharmacology*; D002707:Chlordiazepoxide / Q000494:pharmacology*; D003292:Convulsants / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007398:Interpersonal Relations; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001570:Benzodiazepinones; D003292:Convulsants; D001569:Benzodiazepines; D002707:Chlordiazepoxide; C022193:Ro 5-3663