title: Cochlear prostheses: stimulation-induced damage.
abstract: The effects of 4 weekly, three-hour exposures to continuous sinusoidal (l kHz) electrical stimulation of the inner ear at various current levels were assessed in the chronically implanted guinea pig. With scala tympani stimulation, histopathological damage, including new bone growth, was observed for currents at and above 100 microA rms. No changes were observed in similarly implanted, but not stimulated cochleas. At equal current levels, less damage was found in subjects stimulated via electrodes placed on the round window and promontory, as compared to the scala tympani. Consistent reversible changes in threshold and suprathreshold features of the electrically evoked auditory brainstem response (EABR) were found. The magnitude of EABR change was directly related to exposure stimulus current level and to cochlear stimulation site. Suprathreshold features of the EABR were more sensitive to continuous stimulation exposures than threshold measures. Reversible EABR changes were found in the presence and absence of stimulation-induced histopathology.
mesh_terms: D000818:Animals; D001933:Brain Stem / Q000502:physiology; D003051:Cochlea / Q000473:pathology / Q000648:ultrastructure; D003054:Cochlear Implants / Q000009:adverse effects*; D005072:Evoked Potentials, Auditory; D006168:Guinea Pigs; D008855:Microscopy, Electron, Scanning; D009925:Organ of Corti / Q000473:pathology / Q000648:ultrastructure; D011897:Random Allocation