title: Genetic differentiation in Dogrib Indians: serum protein and erythrocyte enzyme variation.
abstract: Fourteen polymorphic and 24 monomorphic serum protein and erythrocyte enzyme systems were studied in Dogrib Indians living in three villages in the Northwest Territories of Canada. New information on the subtypes of Gc is provided, as is the description of a new variant at the galactose-1-phosphate uridyl transferase (GALT) locus. Maximum European admixture in the Dogrib is 8.7%. Contingency chi-square analysis indicates significant genetic differentiation among the villages. Nei's (1973) GST = .0083 +/- .0022 over 36 systems, including blood groups. This compares favorably with GST obtained for three Macushi subdivisions, but appears to exceed that observed among the Xavante Indians of South America.
mesh_terms: D000328:Adult; D001798:Blood Proteins / Q000235:genetics*; D002170:Canada; D002352:Carrier Proteins / Q000235:genetics; D004798:Enzymes / Q000235:genetics*; D004912:Erythrocytes / Q000201:enzymology; D005787:Gene Frequency; D014644:Genetic Variation; D005828:Genetics, Population; D006801:Humans; D007198:Indians, North American; D005694:UTP-Hexose-1-Phosphate Uridylyltransferase / Q000235:genetics; D014809:Vitamin D-Binding Protein
chemical_list: D001798:Blood Proteins; D002352:Carrier Proteins; D004798:Enzymes; D014809:Vitamin D-Binding Protein; D005694:UTP-Hexose-1-Phosphate Uridylyltransferase