Action of CDP-choline by intraduodenal route on rat cardiorespiratory system.
The influence of an acute treatment with cytidine diphosphate choline (CDP-choline, citicoline, Somazina) by intraduodenal route on cardiovascular and respiratory parameters in anesthetized rats is studied. No differences as compared with controls were observed in heart and respiratory rates. The values in arterial pressure and respiratory flow for CDP-choline groups were observed to be near the basal values. The inspiratory flow shows a statistically significant difference (approaching basal values) as compared with the decrease in controls.
D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects*; D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000633:toxicity*; D004386:Duodenum; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D007267:Injections; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects; D012137:Respiratory System / Q000187:drug effects*
D003566:Cytidine Diphosphate Choline; D002794:Choline