Synthesis of potential antihypertensive compounds: N-(4,5-dihydroimidazol-2-yl-amino)pyrroles.
A series of N-(4,5-dihydroimidazol-2-yl-amino)pyrroles (V) were prepared by reaction of the 2-hydrazino-2-imidazolines with 2,5-diketones. Noticeable oral antihypertensive activity in renal hypertensive dogs was shown by N-(4,5-dihydroimidazol-2-yl-amino)-2,5-dimethyl pyrrole.
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D001794:Blood Pressure / Q000187:drug effects; D003000:Clonidine / Q000494:pharmacology; D004285:Dogs; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007928:Lethal Dose 50; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000959:Antihypertensive Agents; D007093:Imidazoles; D011758:Pyrroles; D003000:Clonidine