Neuromuscular blocking action of atracurium in the dog and its reversal by neostigmine.
The drug, atracurium besylate is one of a new series of competitive muscle relaxants. Doses of 0.2, 0.4 and 0.6 mg/kg produced neuromuscular block in the anaesthetised dog with no cardiovascular effects. The neuromuscular block was readily reversible by neostigmine.
D000818:Animals; D001279:Atracurium; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007546:Isoquinolines / Q000008:administration & dosage* / Q000037:antagonists & inhibitors / Q000494:pharmacology; D009388:Neostigmine / Q000494:pharmacology*; D009466:Neuromuscular Blocking Agents / Q000008:administration & dosage* / Q000037:antagonists & inhibitors / Q000494:pharmacology
D007546:Isoquinolines; D009466:Neuromuscular Blocking Agents; D001279:Atracurium; D009388:Neostigmine