[Possible substances which block the rosette formation of peripheral lymphocyte Fc receptor to sensitized corpuscle (EA) in the serum of patients with gastric and colon cancer].
Possible substances which block the rosette formation of peripheral lymphocyte Fc-receptor to sensitized corpuscle (EA) was discovered in the serum from patients with cancer of the digestive system, and was designated as EA rosette formation inhibitor (EAI). The immunological and clinical significance of EAI was studied. Considering the activity of EAI being correlated with serum CH50 or immune complex level measured by "Raji cell method", the activity of EAI is mainly attributed to blood immune complexes. In addition, concentration of EAI was not correlated with non-specific cellular immunity. However, in the patients with high serum EAI level, the rate of peripheral lymphocytic transformation stimulated with PHA tend to be lower, but that with Con A tend to be higher. These observation suggested that suppressor T cell was activated by binding with immune complex. Serum EAI level was studied in patients with 74 gastric cancer and 70 with colon cancer before and after treatment. The results obtained revealed that EAI was frequently detected in pretreatment cases and it was decreased after operation or immunochemotherapy. Ultimately, EAI could be one of the specific parameter for diagnosis and treatment of cancer patients from immunological aspects.
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex / Q000032:analysis; D003110:Colonic Neoplasms / Q000276:immunology* / Q000601:surgery; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011961:Receptors, Fc / Q000032:analysis*; D012397:Rosette Formation; D013274:Stomach Neoplasms / Q000276:immunology* / Q000601:surgery
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D011961:Receptors, Fc