Thrombotic thrombocytopenic purpura during penicillamine therapy in rheumatoid arthritis.
Thrombotic thrombocytopenic purpura (TTP) developed in a patient with seropositive rheumatoid arthritis (RA) after 2 1/2 months of treatment with penicillamine. After discontinuation of the drug, plasmapheresis and steroid therapy led to a sustained remission. To our knowledge, no prior cases of penicillamine-induced TTP in RA have been reported.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000009:adverse effects*; D010976:Platelet Count; D011696:Purpura, Thrombocytopenic / Q000139:chemically induced*
D010396:Penicillamine