Acylated derivatives of 1,5-benzodiazepines.
N-Acylated derivatives of 2-methyl-2-ethoxycarbonyl-4-phenyl-1H-tetrahydro-1,5-benzodiazepine (1) and 2-cyano-4-methyl-1H-tetrahydro-1,5-benzodiazepine (3-12) were obtained. From among compounds 3-12, compound 3 have shown a strong synergism with hexobarbital and antiserotonin and anticonvulsant activity, and compounds 5 and 7 have displayed antiserotonin properties. A strong antireserpine action, comparable with imipramine, has been found for compound 12, which also have antagonized electrogenic seizures.
D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D000927:Anticonvulsants / Q000138:chemical synthesis; D001569:Benzodiazepines / Q000138:chemical synthesis* / Q000494:pharmacology; D006591:Hexobarbital / Q000494:pharmacology; D007928:Lethal Dose 50; D051379:Mice; D011619:Psychotropic Drugs / Q000138:chemical synthesis*; D012110:Reserpine / Q000037:antagonists & inhibitors; D012702:Serotonin Antagonists / Q000138:chemical synthesis
D000700:Analgesics; D000927:Anticonvulsants; D011619:Psychotropic Drugs; D012702:Serotonin Antagonists; D001569:Benzodiazepines; D012110:Reserpine; D006591:Hexobarbital