title: Fibrous thickening of the splenic capsule. A response to chronic splenic congestion.
abstract: Fibrous thickening of the splenic capsule is often seen in patients with hepatic cirrhosis or portal hypertension from other causes. However, most cases of capsular thickening have been considered idiopathic, with no obvious abnormality of the portal circulation. The possibility that these "idiopathic" cases also have evidence of portal hypertension was examined in a retrospective study. The splenic capsule thickness was measured in 434 consecutive autopsy specimens. Various clinical and autopsy parameters relevant to vascular disease were recorded and correlated with splenic capsular thickness. Thickened capsules were significantly more frequent in patients with advanced age, clinical history of severe congestive heart failure, cirrhosis, and hepatic portal sclerosis. It is suggested that most cases of splenic capsular thickening are caused by splenic congestion with organization of capsular and subcapsular hemorrhages.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D002908:Chronic Disease; D006333:Heart Failure / Q000150:complications / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications; D008875:Middle Aged; D011169:Portal Vein / Q000473:pathology*; D012598:Sclerosis; D013154:Spleen / Q000098:blood supply* / Q000473:pathology / Q000503:physiopathology; D013158:Splenic Diseases / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology