A comparative assessment of a new antacid formulation based on magaldrate.
A new antacid formulation (Dynese) based on magaldrate, a discrete chemical entity with marked antacid properties, has been compared in vitro with several commercially available antacid preparations. All preparations were tested for their ability to maintain gastric pH within acceptable limits and to effectively bind bile acids. Sodium concentrations were also determined. Dynese was shown to compare very favourably with existing preparations in that it had a prolonged even neutralization profile, efficient bile acid binding properties and a low sodium content.
D000536:Aluminum Hydroxide / Q000378:metabolism / Q000494:pharmacology*; D000863:Antacids / Q000378:metabolism / Q000494:pharmacology*; D001647:Bile Acids and Salts / Q000378:metabolism; D005744:Gastric Acid / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D008274:Magnesium / Q000494:pharmacology*; D008276:Magnesium Hydroxide / Q000378:metabolism / Q000494:pharmacology*; D012964:Sodium / Q000032:analysis
D000863:Antacids; D001647:Bile Acids and Salts; D000536:Aluminum Hydroxide; C016545:magaldrate; D012964:Sodium; D008274:Magnesium; D008276:Magnesium Hydroxide