title: Changes in contractility and oxygen metabolism of isolated canine heart following application of urapidil.
abstract: Changes of contractility and oxygen metabolism following the administration of urapidil (Ebrantil) are described. Investigations were carried out on isolated, metabolically supported canine hearts. Results show that this drug has a myocardial effect in addition to its known antihypertensive effect. Moreover, a dose-dependent negative inotropism is coupled with a reduction in myocardial oxygen consumption. Urapidil reduces the cardiac metabolic rate, decreases cardiac load due to a reduction in peripheral resistance, and has a negative inotropic action. These properties are usually found only in beta-blockers.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003331:Coronary Vessels / Q000187:drug effects; D004285:Dogs; D066298:In Vitro Techniques; D007275:Injections, Intravenous; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D010879:Piperazines / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D010879:Piperazines; C015568:urapidil