title: Effect of pinealectomy on heat-induced endocrine changes in female rats.
abstract: Exposure of pinealectomized rats to high ambient temperature (35 degrees C; PXH) brought about a diminution in pituitary weight and LH content when compared to their sham-operated peers (35 degrees C) or to pinealectomized controls (22 degrees C). Serum corticosterone level of PXH rats was significantly depressed while heat or pinealectomy alone had no effect. Mean oestrous cycle length was prolonged and blood serum progesterone was increased in the heat-exposed rats. However, the extended oestrous cycles and elevated serum progesterone levels of heat-exposed rats were depressed or abolished by pineal ablation. Thus, the pineal appears to exert a moderating effect on heat-induced endocrine changes in female rats. No changes were noticed in uterine and ovarian weights corrected for body weights either on the day of vaginal opening, at occurrence of the oestrous phase expressed as percentage of total oestrous cycle, or in N-acetyltransferase and hydroxyindole-O-methyltransferase activities.
mesh_terms: D000818:Animals; D001835:Body Weight; D004702:Endocrine Glands / Q000502:physiology*; D004971:Estrus; D005260:Female; D006728:Hormones / Q000097:blood; D006358:Hot Temperature; D009929:Organ Size; D010053:Ovary / Q000502:physiology; D010870:Pineal Gland / Q000502:physiology*; D010902:Pituitary Gland / Q000502:physiology; D011247:Pregnancy; D051381:Rats; D014599:Uterus / Q000502:physiology
chemical_list: D006728:Hormones