title: Massive increase in splenic germinal centres of chickens experimentally-infected with Trypanosoma brucei brucei.
abstract: Domestic chickens infected with Trypanosoma brucei brucei developed a latent parasitaemia which lasted for one year. Six distinct variable antigen types were isolated. Spleens from infected birds were studied histologically at different stages of the infection. Trypanosome infection produced a progressive increase in the number of germinal centres during the early stages of the infection. Peak numbers of germinal centres were reached in the spleen at Day 84 after which the numbers were maintained during an active infection. A tenfold increase in the number of germinal centres was found in trypanosome-infected birds compared to controls. No splenomegaly was observed. Lymphoid cells of the caecal tonsil and the thymus remained apparently normal during the course of infection. Chemotherapeutic termination of infection with berenil resulted in an initial increase in the number of germinal centres. A gradual return to normal level was observed on Day 100 post cure. It is suggested that the development of such a large number of germinal centres reflects the bird's response to the elaboration of a succession of trypanosome variable antigens.
mesh_terms: D000818:Animals; D000941:Antigens / Q000276:immunology; D001769:Blood / Q000469:parasitology; D002645:Chickens / Q000276:immunology*; D008297:Male; D051379:Mice; D011201:Poultry Diseases / Q000276:immunology* / Q000473:pathology; D013154:Spleen / Q000276:immunology* / Q000473:pathology; D014346:Trypanosoma brucei brucei / Q000276:immunology; D014353:Trypanosomiasis, African / Q000276:immunology / Q000473:pathology / Q000662:veterinary*
chemical_list: D000941:Antigens