[Suppression of thymus endocrine function and changes in the plasma membrane properties of the lymphocytes in the chemotherapy of systemic oncological diseases in children].
An examination of 16 children suffering from malignancies established marked chemotherapy--induced suppression of endocrine function of the thymus. These findings were in correlation with variations in peripheral blood lymphocytes level in spontaneous rosette-formation test with ovine red blood cells and autoerythrocytes. The levels of E- and A-rosette-forming cells returned to normal following in vitro incubation of peripheral blood lymphocytes with thymostimuline. It is suggested that immunocorrection by means of thymal hormones should be carried out in the course of chemotherapy.
D000293:Adolescent; D002462:Cell Membrane / Q000187:drug effects / Q000276:immunology; D002648:Child; D003520:Cyclophosphamide / Q000008:administration & dosage; D003864:Depression, Chemical; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000503:physiopathology; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D008223:Lymphoma / Q000188:drug therapy* / Q000503:physiopathology; D012397:Rosette Formation; D013935:Thymic Factor, Circulating / Q000032:analysis; D013950:Thymus Gland / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors; D014747:Vinblastine / Q000008:administration & dosage
D014747:Vinblastine; D003520:Cyclophosphamide; D013935:Thymic Factor, Circulating
Ugnetenie éndokrinnoi funktsii timusa i izmenenie svoĭstv plazmaticheskoĭ membrany limfotsitov pri khimioterapii sistemnykh onkologicheskikh zabolevaniĭ u deteĭ.