The right auricle of the heart is an endocrine organ. Cardiodilatin as a peptide hormone candidate.
A new polypeptide hormone candidate regulating vascular smooth muscle function was extracted from porcine atrial tissue. The purification steps were followed by a bioassay. The hormonally active substance has been analyzed and found to be a small polypeptide exhibiting a molecular weight of about 7500 and is named "cardiodilatin" (CDD). Further chemical data on this new hormone will be published elsewhere. A partial amino acid sequence of cardiodilatin is offered and shows that among the well known hormones or neuropeptides, none exhibit a homologue partial sequence.
D000595:Amino Acid Sequence; D000818:Animals; D016275:Atrial Function; D009320:Atrial Natriuretic Factor; D003594:Cytoplasmic Granules / Q000648:ultrastructure; D004702:Endocrine Glands / Q000502:physiology*; D006325:Heart Atria / Q000648:ultrastructure; D006728:Hormones / Q000302:isolation & purification* / Q000494:pharmacology; D008970:Molecular Weight; D009126:Muscle Relaxation; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D010455:Peptides / Q000302:isolation & purification* / Q000494:pharmacology; D013552:Swine; D014020:Tissue Extracts / Q000032:analysis
D006728:Hormones; D010455:Peptides; D014020:Tissue Extracts; D009320:Atrial Natriuretic Factor; C040651:cardiodilatin