The antinociceptive effect of ketobemidone in comparison with Ketogin.
The antinociceptive effect of ketobemidone, A 29 (N,N-dimethyl-3,3-diphenyl-l-methyl-alkylamine chloride) and Ketogin (combination of ketobemidone and A 29) has been investigated in mice and rats. The hot plate, grid shock, phenylquinone and Randall-Selitto test were used. Ketobemidone caused antinociception whereas A 29 was without effect. Ketogin was in comparison with ketobemidone more potent. The mechanism of the potentiating effect of A 29 remains to be clarified.
D000499:Allylamine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000588:Amines / Q000494:pharmacology*; D000700:Analgesics; D000818:Animals; D016227:Benzoquinones; D004338:Drug Combinations / Q000494:pharmacology; D004597:Electroshock; D008297:Male; D008614:Meperidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D051379:Mice; D010146:Pain / Q000503:physiopathology; D011809:Quinones / Q000037:antagonists & inhibitors; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D012684:Sensory Thresholds / Q000187:drug effects; D013045:Species Specificity; D013997:Time Factors
D000588:Amines; D000700:Analgesics; D016227:Benzoquinones; D004338:Drug Combinations; D011809:Quinones; C029322:phenylbenzoquinone; D000499:Allylamine; C010597:ketobemidone, N,N-dimethyl-3,3-diphenyl-1-methylallylamine drug combination; D008614:Meperidine; C012394:ketobemidone