Effect of brand on the serum level of aspirin.
The authors present a case of a four-year-old female, treated with aspirin for juvenile rheumatoid arthritis. A generic preparation was given first, but plasma salicylate levels remained significantly below the required therapeutic range. Upon changing to a brand-name product, however, therapeutic levels were achieved after one day. The authors conclude that the source of aspirin used had a marked effect on the serum salicylate level.
D001171:Arthritis, Juvenile / Q000188:drug therapy; D001241:Aspirin / Q000097:blood* / Q000627:therapeutic use; D001682:Biological Availability; D002675:Child, Preschool; D005260:Female; D006207:Half-Life; D006801:Humans; D012459:Salicylates / Q000097:blood; D020156:Salicylic Acid; D012995:Solubility; D013810:Therapeutic Equivalency
D012459:Salicylates; D020156:Salicylic Acid; D001241:Aspirin