The effect of urokinase in the prevention of intraperitoneal adhesions; role of blood in their formation.
The effect of blood on the formation of peritoneal adhesions and their prevention with plasmine activator--urokinase was evaluated. Blood was found to cause adhesion to the serosa of the rat uterus when applied through the opened peritoneum while no such adhesions were observed in the rabbit. Urokinase proved to be beneficial in the prevention of both intraperitoneal adhesions caused by trauma alone and those caused by a combination of trauma and fresh blood applied to the traumatized area.
D000005:Abdomen / Q000601:surgery; D000818:Animals; D010532:Peritoneal Diseases / Q000209:etiology / Q000517:prevention & control*; D010537:Peritoneum / Q000098:blood supply*; D011183:Postoperative Complications; D011817:Rabbits; D051381:Rats; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control; D014568:Urokinase-Type Plasminogen Activator / Q000494:pharmacology*
D014568:Urokinase-Type Plasminogen Activator