[Structure and mode of action of bacterial toxins].
This paper provides an overview of the mechanisms by which bacterial exotoxins damage cells of the host organism. The principles of cellular attack are schematically described using typical representants of the various toxin groups as examples. Attention is drawn to structural and functional analogies existing among the toxins, and to related phenomena of cell damage by bacterioicins and the mammalian complement system. The development of immunotoxins illustrates the potential importance of basic research in toxinology and immunology to modern medicine.
D000818:Animals; D001427:Bacterial Toxins / Q000633:toxicity*; D002462:Cell Membrane / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002772:Cholera Toxin / Q000633:toxicity; D003087:Colicins / Q000633:toxicity; D004167:Diphtheria Toxin / Q000633:toxicity; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000648:ultrastructure; D006801:Humans; D008970:Molecular Weight; D009498:Neurotoxins / Q000633:toxicity; D013329:Structure-Activity Relationship
D001427:Bacterial Toxins; D003087:Colicins; D004167:Diphtheria Toxin; D009498:Neurotoxins; D002772:Cholera Toxin
Struktur und Wirkmechanismen bakterieller Toxine.