Facilitation of thermoregulatory heating behavior by single cortical spreading depression in the rat.
Effects of single waves of unilateral cortical spreading depression (CSD) on skin-heating behavior were studied in the rat with the unilateral lesion in the preoptic and anterior hypothalamus (PO/AH). A single CSD contralateral to the PO/AH lesion significantly increased the number of heating for 4 min after CSD had entered the frontal cortex with a maximum facilitation rate 20% above the pre-CSD level. On the other hand, a single CSD ipsilateral to the PO/AH lesion slightly augmented the number of heating for 2 min with a maximum increase of 8% above the pre-CSD level. An injection of 0.9% NaCl (non-CSD trial) did not affect the skin-heating behavior. The present results, together with the changes in skin-cooling behavior during CSD reported previously, suggest the involvement of the frontal cortex in the central control of thermoregulation.
D000818:Animals; D007025:Anterior Hypothalamic Nucleus / Q000502:physiology*; D001833:Body Temperature Regulation; D013181:Cortical Spreading Depression; D004292:Dominance, Cerebral / Q000502:physiology; D005625:Frontal Lobe / Q000502:physiology*; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D011301:Preoptic Area / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012881:Skin Temperature; D013823:Thermoreceptors / Q000502:physiology