title: Effect of weightlessness on myofibrillar proteins of rat skeletal muscles with different functions in experiment of biosatellite "Cosmos-1129".
abstract: The composition of contractile and regulatory proteins was studied in rat muscles with different functions. The rats were exposed to weightlessness for 18.5 days during a space journey in biosatellite Cosmos-1129. Under the effect of weightlessness the myosin light chain composition changed, the quantity of myosin LC-3 subunits increased in the soleus and extensor digitorum longus (EDL) while it decreased in the triceps and brachialis muscles. The experiments showed changes in the subunit composition of the TN-TM complex, too. The results obtained are in favour of a possible adequate transformation of fibril phenotypes of some (antigravitational) muscles under the effect of spaceflight.
mesh_terms: D000818:Animals; D008297:Male; D009124:Muscle Proteins / Q000032:analysis*; D009132:Muscles / Q000502:physiology*; D009210:Myofibrils / Q000032:analysis*; D009218:Myosins / Q000032:analysis / Q000145:classification; D051381:Rats; D011919:Rats, Inbred Strains; D013026:Space Flight; D014893:Weightlessness
chemical_list: D009124:Muscle Proteins; D009218:Myosins