title: Intra-blood-brain barrier measles virus antibody synthesis in multiple sclerosis patients.
abstract: Antibodies to nine viruses were measured in serum and CSF of MS patients, patients with other neurologic diseases (OND), and healthy controls. The extent of antibody production inside the blood-brain barrier (BBB) was determined by making a new correction for BBB permeability. Compared with OND and healthy controls, MS patients as a group had significantly higher corrected CSF:serum antibody ratios for measles virus but not to the other eight viruses studied. The incidence of significantly high CSF:serum ratios for measles antibody in MS patients was 50%, and in the other two control groups it was 0 to 12%. The incidence of corrected antibody ratios to the other eight viruses was not significantly different among the three groups.
mesh_terms: D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis* / Q000134:cerebrospinal fluid; D001812:Blood-Brain Barrier; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D008459:Measles virus / Q000276:immunology*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000276:immunology*; D010539:Permeability
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G