The analysis of [14C]clofibric acid glucuronide and [14C]clofibric acid in plasma and urine using high-performance liquid chromatography.
A high-performance liquid chromatographic method has been developed for the quantitation of [14C]clofibric acid glucuronide and [14C]clofibric acid using conventional scintillation counting. The assay has a linear relationship between the added and observed ratios of clofibric acid glucuronide: clofibric acid in the range of 0.001-0.6 for plasma and 0.5-100 for urine, and is able to quantitate previously unmeasurable concentrations of clofibric acid glucuronide in plasma.
D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002994:Clofibrate / Q000031:analogs & derivatives*; D002995:Clofibric Acid / Q000031:analogs & derivatives* / Q000032:analysis* / Q000097:blood / Q000652:urine; D004355:Drug Stability; D006207:Half-Life; D006868:Hydrolysis; D008297:Male; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains
D002995:Clofibric Acid; C030678:clofibric pyranoglucuronate; D002994:Clofibrate