Differential effects of morphine, dopamine and prolactin administered iontophoretically on arcuate-ventromedial hypothalamic neurons.
The effect of iontophoretically applied morphine, dopamine and prolactin on the spontaneous, extracellular electrical activity of arcuate-ventromedial hypothalamic neurons was studied in urethane-anesthetized female rats. The deposition of morphine and dopamine suppressed, while prolactin was found to enhance, the rate of spontaneous firing of more than half of the neurons recorded. It is suggested that the present findings may be of significance in the understanding of the interaction of the opioids, dopamine, and prolactin in the regulation of prolactin secretion.
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000187:drug effects*; D004031:Diestrus; D004298:Dopamine / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D007478:Iontophoresis; D009020:Morphine / Q000008:administration & dosage* / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects*; D011247:Pregnancy; D011388:Prolactin / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D014697:Ventromedial Hypothalamic Nucleus / Q000187:drug effects*
D009020:Morphine; D011388:Prolactin; D004298:Dopamine