Analysis and microbiological stability of an isosorbide 50% mixture.
Isosorbide mixture containing 50% w/v isosorbide and 5% w/v sorbitol is used in the treatment of hydrocephalus. The G.L.C. analysis of the mixture is described and its antimicrobial properties investigated. Results for the determination of lead in the mixture are given and the significance of the levels discussed with relevance to the treatment of infants.
D001419:Bacteria; D002849:Chromatography, Gas; D004340:Drug Contamination; D004355:Drug Stability; D007547:Isosorbide / Q000032:analysis*; D007854:Lead / Q000032:analysis; D012996:Solutions; D013012:Sorbitol / Q000031:analogs & derivatives*; D013997:Time Factors
D012996:Solutions; D007854:Lead; D013012:Sorbitol; D007547:Isosorbide