[Effect of proteins S100 on RNA and protein biosynthesis in neurons and glial cells of the rat brain].
The effects of brain-specific proteins S100 injected into lateral ventricles of rat brain on biosyntheses of RNA, proteins and endogenous proteins S100 in neurons and glial cells were investigated. It was found that exogenous proteins S100 essentially and irreversibly stimulate RNA and total protein syntheses in glial cells, while bovine serum albumin stimulates RNA and protein syntheses in neurons but not in glial cells. The dynamics of changes in the content of newly synthesized endogenous proteins S100 in glial cells and neurons are suggestive of transport of S100 protein molecules synthesized by glial cells, into the neurons. The absence of appreciable changes in the indicated parameters in rats injected with total rabbit sera proteins as well as in animals subjected to "false injections" provide evidence for the specificity of metabolic effects of proteins S100 and serum albumin.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D009457:Neuroglia / Q000187:drug effects / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000187:drug effects*; D051381:Rats; D009418:S100 Proteins / Q000235:genetics / Q000494:pharmacology*; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D014158:Transcription, Genetic / Q000187:drug effects*
D009418:S100 Proteins; D012710:Serum Albumin, Bovine
Vliianie belkov gruppy S100 na biosintez RNK i belkov v neĭronakh i glial'nykh kletkakh golovnogo mozga krys.