The effect of vasoactive intestinal polypeptide on meal-stimulated gastric acid secretion in man.
The effect of vasoactive intestinal polypeptide (VIP) on meal-stimulated gastric acid secretion was studied in six healthy volunteers. Acid secretion was stimulated by instillation of a 10% solution of peptone, which was adjusted to pH 5.5, circulated through the stomach via a double-lumen gastric tube by a peristaltic pump. The acid secretion was estimated by continuous titration by a pH-stat. The subjects were studied twice on separate days, receiving an intravenous infusion of either VIP (1 microgram/kg/h) or saline. No effect on acid secretion was found. Mean serum gastrin concentration rose from 42 pmol/l to 150 pmol/l during meal stimulation and was unaffected by infusion of VIP. Plasma VIP concentration during infusion of saline was 6.8 pmol/l and during VIP infusion, 82.8 pmol/l. Plasma VIP concentration was unaffected by the peptone meal.
D000328:Adult; D005260:Female; D005502:Food; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D010461:Peptones / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000097:blood / Q000494:pharmacology*
D005755:Gastrins; D010461:Peptones; D014660:Vasoactive Intestinal Peptide; D012965:Sodium Chloride