Aldehyde content of collagen from liver of rats with collagen-like syndrome.
Collagen was obtained from liver tissue of rats with hydralazine-induced collagen-like syndrome. Bacterial collagenase was used to solubilize the collagen, and the aldehyde content of this material was measured using N-methyl benzothiazolone hydrazone. The aldehyde content was decreased in the in the collagen from livers of rats with collagen-like syndrome. The changes in hepatic collagen may be analogous to the effect of aging on collagen, wherein collagen cross-linking is strengthened although qualitative changes in cross-linking may lower the measurable aldehydes.
D000447:Aldehydes / Q000032:analysis*; D000818:Animals; D003094:Collagen / Q000032:analysis*; D003095:Collagen Diseases / Q000378:metabolism*; D006601:Hexoses / Q000032:analysis; D006909:Hydroxyproline / Q000032:analysis; D008099:Liver / Q000032:analysis*; D008297:Male; D051381:Rats; D013577:Syndrome
D000447:Aldehydes; D006601:Hexoses; D003094:Collagen; D006909:Hydroxyproline