Cytotoxicity of cyclodepsipeptides on murine lymphocytes and on L 1210 leukemia cells.
By in vitro experiments we have demonstrated an important cytotoxic effect of destruxins A, A2, B, B1 and E on L 1210 leukemia cells. This cytotoxic effect was measured by DNA synthesis. The cytotoxic effect on normal mouse spleen lymphocytes was also evaluated. For the most cytotoxic compound, destruxin E, 16 mg/kg was found to be the minimal dose necessary to kill all mice.
D000818:Animals; D000970:Antineoplastic Agents; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D047630:Depsipeptides; D005656:Fungal Proteins; D007939:Leukemia L1210 / Q000188:drug therapy*; D008214:Lymphocytes / Q000187:drug effects*; D051379:Mice; D008811:Mice, Inbred DBA; D009183:Mycotoxins; D010456:Peptides, Cyclic / Q000494:pharmacology* / Q000633:toxicity
D000970:Antineoplastic Agents; D047630:Depsipeptides; D005656:Fungal Proteins; D009183:Mycotoxins; D010456:Peptides, Cyclic; C040423:destruxin A; C040427:destruxin B1; C040426:destruxin A2; C040424:destruxin B; C040425:destruxin E