Inhibition of development of preneoplastic lesions in the livers of rats fed a weakly carcinogenic environmental contaminant.
The effects of di(2-ethylhexyl)phthalate (DEHP), a widely used plasticizer and environmental contaminant, on the emergence of gamma-glutamyltrans-peptidase positive (GGT+) preneoplastic foci in the liver was investigated. Sprague--Dawley male rats initiated with diethylnitrosamine (DEN) following partial hepatectomy were placed on: (1) a choline supplemented diet (CS); (2) a CS diet containing 2% DEHP (CS + DEHP); (3) a choline deficient diet (CD); (4) a CD diet containing a 0.06% phenobarbital (CD + PHB); or (5) a CD diet containing 2% DEHP (CD + DEHP). Rats maintained on the CS + DEHP diet for 5 and 10 weeks showed no increase in GGT + foci. The plasticizer effectively inhibited the appearance of the preneoplastic foci when it was included with the CD diet.
D000818:Animals; D001835:Body Weight; D004032:Diet; D004051:Diethylhexyl Phthalate / Q000494:pharmacology*; D004052:Diethylnitrosamine; D004347:Drug Interactions; D004790:Enzyme Induction; D006498:Hepatectomy; D008099:Liver / Q000201:enzymology; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000517:prevention & control; D008297:Male; D009602:Nitrosamines; D010795:Phthalic Acids / Q000494:pharmacology*; D011230:Precancerous Conditions / Q000139:chemically induced* / Q000517:prevention & control; D000091402:Prohibitins; D051381:Rats; D011919:Rats, Inbred Strains
D009602:Nitrosamines; C000717332:Phb protein, rat; D010795:Phthalic Acids; D000091402:Prohibitins; D004052:Diethylnitrosamine; D004051:Diethylhexyl Phthalate