Combined timolol and epinephrine therapy for open angle glaucoma.
A survey of the literature concerning the interaction of timolol and epinephrine in lowering intraocular pressure, and a study comparing the efficacy of timolol and dipivefrin (a prodrug of epinephrine) to that of timolol and pilocarpine are presented. These observations suggest that timolol-epinephrine therapy is less effective than timolol-pilocarpine treatment, although the former combination has clinical value in some patients, and it is possible that this can be enhanced when special schedules for drug administration are used.
D004359:Drug Therapy, Combination; D004837:Epinephrine / Q000008:administration & dosage* / Q000031:analogs & derivatives; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D010862:Pilocarpine / Q000008:administration & dosage; D011897:Random Allocation; D013999:Timolol / Q000008:administration & dosage*
D010862:Pilocarpine; D013999:Timolol; C015173:dipivefrin; D004837:Epinephrine