The release of Met-enkephalin from the guinea-pig ileum at rest and during peristaltic activity.
Segments of guinea-pig ileum maintained at an intraluminal pressure of 0cm H2O released methionine-enkephalin-like material (ME) into the bathing fluid. Elevation of intraluminal pressure to 5 cm H2O induced peristalsis and reduced ME release both in the absence and presence of naloxone (0.27 microM). Following prolonged distension, tissues developed intermittent peristaltic activity. ME release during intermittency was consistently and significantly (p less than 0.05) greater than that observed from tissues exhibiting continuous peristalsis. These results suggest that ME release is associated with nonpropulsive activity in the guinea-pig ileum.
D000818:Animals; D004744:Enkephalin, Methionine / Q000378:metabolism*; D005769:Gastrointestinal Motility / Q000187:drug effects; D006168:Guinea Pigs; D007082:Ileum / Q000378:metabolism* / Q000502:physiology; D066298:In Vitro Techniques; D009270:Naloxone / Q000494:pharmacology; D010528:Peristalsis / Q000187:drug effects
D009270:Naloxone; D004744:Enkephalin, Methionine