[Treatment of idiopathic thrombocytopenic purpura in adults with high-dosage immunoglobulins].
Four of five patients with idiopathic thrombocytopenic purpura (ITP) responded to high-dose immunoglobulin treatment with transitory rise in platelet count to normal values, while the fifth had only minimal improvement. In the individual case there was good correlation between serum-IgG concentration and platelet count, but an influence on platelet-associated IgG could not be demonstrated with certainty. Treatment with high-dose IgG is apparently particularly suitable for patients with ITP refractory to steroids or splenectomy, in whom bleeding complications or operative procedures make a transitory rise in platelet count desirable.
D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000276:immunology; D002908:Chronic Disease; D004306:Dose-Response Relationship, Immunologic; D006801:Humans; D007116:Immunization, Passive; D007074:Immunoglobulin G / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011696:Purpura, Thrombocytopenic / Q000276:immunology / Q000628:therapy*; D013997:Time Factors
D007074:Immunoglobulin G
Behandlung der idiopathischen thrombozytopenischen Purpura des Erwachsenen mit hochdosierten Immunglobulinen.