[Piperacillin concentration in the pelvic dead space exudate following surgery of cervical cancer].
Twelve patients with uterocervical cancer had panhysterectomy and were administered piperacillin (PIPC) at a dose of 2 g by one shot injection 2 times a day for a period of 5--6 days. PIPC concentrations in serum and pelvic dead space exudate were investigated before and after administration for 3 days (5 times). Serum concentration was observed ca. 49 micrograms/ml at 1 hour after the first, third and fifth administration. Concentrations in pelvic dead space exudate at 1 hour after the first, third and fifth administration were observed 26.7 +/- 5.8, 10.8 +/- 4.0 and 8.7 +/- 3.5 micrograms/ml, respectively. The highest concentration was 63.0 micrograms/ml at 1 hour after the first administration in case 4. It was thought that these concentrations were sufficient for the therapy of parametritis. No side effects caused by the drug were observed.
D000368:Aged; D005122:Exudates and Transudates / Q000378:metabolism*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D010388:Pelvis / Q000378:metabolism*; D010878:Piperacillin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D011184:Postoperative Period; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000378:metabolism* / Q000601:surgery
D010878:Piperacillin