Contraception with danazol plus testosterone enanthate in the rabbit. I. Effects on vas deferens.
Effects of danazol plus testosterone enanthate on rabbit vas deferens are investigated. Seminal, biochemical tissue and histological studies were performed. Sperm motility was markedly impaired with the advancement of treatment. At the end of treatment 75 per cent of the animals became azoospermic. Seminal fructose did not change, whereas citric acid showed a progressive non-significant increase. Phosholipid and protein contents of vas deferens decreased during drug exposure. No appreciable changes were observed in sialic acid concentration. Citric acid and fructose in ampullae reduced following 60 days of treatment. Vas deferens lumen was devoid of spermatozoa. The combination therapy impaired the secretory activity of vas deferens reversibly.
D000818:Animals; D002951:Citrates / Q000378:metabolism; D019343:Citric Acid; D003613:Danazol / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D005298:Fertility / Q000187:drug effects*; D005632:Fructose / Q000378:metabolism; D008297:Male; D011245:Pregnadienes / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism; D011817:Rabbits; D012661:Semen / Q000187:drug effects; D013076:Sperm Count; D013081:Sperm Motility / Q000187:drug effects; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D014649:Vas Deferens / Q000187:drug effects*
D002951:Citrates; D011245:Pregnadienes; D011506:Proteins; D019343:Citric Acid; D005632:Fructose; D013739:Testosterone; C004648:testosterone enanthate; D003613:Danazol