Absorption and excretion of suprofen in both sexes of rats, guinea pigs, and rabbits.
DL-2-(4-2-Thienylcarbonyl)phenyl)propionic acid (suprofen) was rapidly absorbed in both sexes of rats, guinea pigs, and rabbits after oral administration. Blood levels after a single dose of 2 mg/kg 3H-suprofen in all the animals reached maxima within 15 min, and elimination of the 3H from blood was rapid; the radioactivity was mostly excreted in the urine and feces within 24 h after dosing.
D000284:Administration, Oral; D000818:Animals; D005243:Feces / Q000032:analysis; D005260:Female; D006168:Guinea Pigs / Q000378:metabolism*; D007408:Intestinal Absorption; D008297:Male; D010666:Phenylpropionates / Q000378:metabolism*; D011817:Rabbits / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains / Q000378:metabolism*; D013045:Species Specificity; D013496:Suprofen / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
D010666:Phenylpropionates; D013496:Suprofen