[Sex hormones binding globulin in lying-in women and their newborn infants with intrauterine malnutrition].
The purpose of this research was to study the binding capacity of estrogens to the sex hormone-binding globulin (SHBG) in mothers and their intrauterine malnourished newborns. Blood samples were obtained from mothers at delivery, and from babies, of the umbilical cord. SHBG was measured according to the method of Mickelson and Petra. It was found in mothers of malnourished babies that the binding capacity of serum protein to dehydrotestosterone (DHT) was significantly decreased in comparison to the controls (10.63 +/- 1.61 vs 13.25 +/- 2.18 micrograms DHT/dl serum, respectively), whereas it was significantly increased in intrauterine malnourished newborns (1.01 +/- 0.24 vs 0.77 +/- 0.18, respectively). These results suggest that SHBG decrease in mothers of intrauterine malnourished newborns occurs due to a decrease in the production of fetal adrenal hormone precursors and may, therefore, be a compensating mechanism to increase placental flow.
D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D010922:Placenta Diseases / Q000097:blood*; D010927:Placental Insufficiency / Q000097:blood*; D049590:Postpartum Period; D011247:Pregnancy; D012738:Sex Hormone-Binding Globulin / Q000032:analysis*
D012738:Sex Hormone-Binding Globulin
Globulina ligante de hormonas sexuales en puérperas y sus recién con desnutrición intrauterina.