title: Increased susceptibility to pentylenetetrazol-induced seizures in adult rats following electrical kindling during brain development.
abstract: The persistence of seizure susceptibility into adulthood following kindling in the immature rat was assessed. Rats kindled electrically at age 30 days were significantly more susceptible to pentylenetetrazol (PTZ)-induced seizures as adults than a control group. These findings demonstrate that kindling in the immature brain results in a permanent alteration in seizure susceptibility.
mesh_terms: D000818:Animals; D001921:Brain / Q000254:growth & development*; D004597:Electroshock; D007696:Kindling, Neurologic; D008297:Male; D010433:Pentylenetetrazole; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000139:chemically induced*
chemical_list: D010433:Pentylenetetrazole