Synthesis of phosphono-pyrimidine and -purine ribonucleosides.
The reaction of the lithiated species of 2', 3', 5'-tri-O-protected uridines and 6-chloropurine ribonucleoside with diethyl chlorophosphate provided the corresponding diethyl phosphonate derivatives (III, IV and VIII). The Arbuzov-reaction of 2', 3', 5'-tri-O-protected 4-chloro-2(1H)-pyrimidinone ribonucleoside with triethyl phosphite afforded the diethyl phosphonate derivative (VI).
D055598:Chemical Phenomena; D002621:Chemistry; D063065:Organophosphonates; D011684:Purine Nucleosides / Q000138:chemical synthesis*; D011741:Pyrimidine Nucleosides / Q000138:chemical synthesis*; D012263:Ribonucleosides / Q000138:chemical synthesis*
D063065:Organophosphonates; D011684:Purine Nucleosides; D011741:Pyrimidine Nucleosides; D012263:Ribonucleosides