title: The effect of low density lipoprotein on in vitro porcine endothelial cell reendothelialization.
abstract: We have studied the effect of low density lipoproteins (LDL) on the ability of porcine thoracic aortic endothelial cells (EC's) to reendothelialize an in vitro experimental wound made in a confluent monolayer culture. Our results show that normolipidemic LDL enhances EC regeneration primarily by acting as a mitogenic agent on the cells in the migrating sheet of cells covering the denuded wound area. There was no evidence of LDL induced cytotoxicity in our study.
mesh_terms: D000818:Animals; D001013:Aorta, Thoracic / Q000166:cytology; D002455:Cell Division; D002465:Cell Movement; D002478:Cells, Cultured; D004727:Endothelium / Q000166:cytology* / Q000502:physiology; D008077:Lipoproteins, LDL / Q000494:pharmacology*; D012038:Regeneration / Q000187:drug effects*; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013552:Swine; D014945:Wound Healing
chemical_list: D008077:Lipoproteins, LDL; D012710:Serum Albumin, Bovine