Treatment of DIC with antithrombin III concentrates.
We administered AT III concentrates to 21 patients with DIC who failed to respond initially to heparin therapy. About 60% of these 21 patients were effectively treated with AT III concentrates by enhancing the effect of heparin and alleviating the burden of excessive plasma transfusions on the cardiovascular system.
D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*; D001777:Blood Coagulation; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006493:Heparin / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D010976:Platelet Count
D000990:Antithrombin III; D006493:Heparin