Metabolic changes in the rat liver during pregnancy. II. Tricarboxylic acid cycle.
During pregnancy the rat liver shows alterations in metabolism which apparently do not to occur in the non-pregnant animal. In our study, the following metabolite concentrations and enzyme activities in the liver of pregnant and non-pregnant rats were measured after fasting periods of 6 and 12 h: malate, fumarate, isocitrate, alpha-keto-glutarate, glutamate, malate-dehydrogenase, fumarate-hydratase, glutamate-dehydrogenase, isocitrate-dehydrogenase, aspartate-aminotransferase and after 12 h fast, the concentrations of acetyl coenzyme A and citrate. These results are discussed with regard to their possible importance for the maternal and fetal energy supply.
D000818:Animals; D002952:Citric Acid Cycle; D005215:Fasting; D005260:Female; D008099:Liver / Q000032:analysis / Q000201:enzymology / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D014233:Tricarboxylic Acids / Q000032:analysis
D014233:Tricarboxylic Acids