Penicillin CSF levels following intravenous therapy in syphilitic patients.
Serum and CSF levels of penicillin have been determined in 13 syphilitic patients treated with relatively high doses of penicillin G by the intravenous route. Wide individual variability in the CSF/serum concentration ratio was observed. In all patients the concentration of the antibiotic in the CSF was equal to or greater than 0.03 IU/ml., which is considered to be the minimal therapeutic concentration. The potential clinical usefulness of different therapeutic regimens in the treatment of neurosyphilis is discussed.
D000328:Adult; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D009494:Neurosyphilis / Q000188:drug therapy*; D010400:Penicillin G / Q000134:cerebrospinal fluid* / Q000627:therapeutic use; D013592:Syphilis, Latent / Q000188:drug therapy*
D010400:Penicillin G