title: Nitrate-induced orthostatic hypotension and long-term circulatory adaptation.
abstract: Acute and initial treatment with ISDN provokes arterial hypotension and orthostatic dysregulation which may persist over a period of 10 h. Collapse as a potential risk has to be taken into account in the initial phase of nitrate therapy. During chronic medication, nitrate-induced drop in arterial blood pressure and orthostatic hypotension cannot longer be seen even after high-dose application of ISDN. From a therapeutic point of view these results indicate adaptation of blood pressure regulation to chronic nitrate therapy which is unrelated to potential tolerance in the venous system.
mesh_terms: D000222:Adaptation, Physiological; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D007024:Hypotension, Orthostatic / Q000139:chemically induced*; D007548:Isosorbide Dinitrate / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged
chemical_list: D007548:Isosorbide Dinitrate