Chronobiologic considerations in human growth hormone therapy.
Because there is a striking diurnal variation in serum growth hormone concentration, the effect of the time of administration of growth hormone replacement therapy was examined in nine children with growth hormone deficiency. No differences in growth rate or somatomedin concentration were noted between morning and evening treatment schedules. Somatomedin concentrations were not constant over the 48 hours between growth hormone injections, and the peak value occurred approximately 24 hours after the growth hormone injection. Thus the timing of growth hormone administration is not an important aspect of growth hormone therapy.
D002648:Child; D002675:Child, Preschool; D002940:Circadian Rhythm / Q000187:drug effects*; D005260:Female; D006130:Growth Disorders / Q000097:blood / Q000188:drug therapy; D013006:Growth Hormone / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D007273:Injections, Intramuscular; D007334:Insulin-Like Growth Factor I; D008297:Male; D011897:Random Allocation; D013002:Somatomedins / Q000097:blood; D013997:Time Factors
D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone