Hemodynamic effects of high dosages of verapamil and the lack of protection by 4-aminopyridine in the rabbit.
4-Aminopyridine (1 mg/kg) restored a 35% fall in arterial blood pressure in rabbits evoked by a verapamil infusion (0.5 mg/kg/min) more effectively than calcium-levulate (approx. 13 mg/kg). However, the lethal dose of verapamil for rabbits (mean: 7.1 mg/kg given by intravenous infusion in 14.3 min) was not affected by 4-aminopyridine pretreatment.
D015761:4-Aminopyridine; D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002317:Cardiovascular Agents / Q000494:pharmacology*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007982:Levulinic Acids / Q000494:pharmacology; D008297:Male; D011817:Rabbits; D014700:Verapamil / Q000494:pharmacology* / Q000633:toxicity
D000631:Aminopyridines; D002317:Cardiovascular Agents; D007982:Levulinic Acids; D015761:4-Aminopyridine; D014700:Verapamil; C032246:levulinic acid