Pharmacokinetics and sputum levels of josamycin after single and multiple administrations in bronchopneumopathic patients.
Josamycin is a new macrolide antibiotic with low toxicity and effective therapeutic activity in many bacterial diseases, particularly bronchopulmonary infections. In the present study the pharmacokinetics of josamycin were investigated in a group of 10 patients suffering from acute exacerbation of chronic bronchitis, with purulent or mucopurulent expectoration. Patients were given one oral administration of 1 g of josamycin every 12 hours for seven days. Serum, urinary parameters and the profile of bronchial mucus diffusion were assessed after the first and the last administration.
D001980:Bronchi / Q000378:metabolism; D001996:Bronchopneumonia / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D007933:Leucomycins / Q000378:metabolism*; D008954:Models, Biological; D009093:Mucus / Q000378:metabolism; D013183:Sputum / Q000378:metabolism*
D007933:Leucomycins