2-Fluoroestradiol. Separation of estrogenicity from carcinogenicity.
Estrogenic and carcinogenic activity are shown to be separable properties. 2-Fluoroestradiol, a modified estrogen, did not induce renal clear-cell carcinoma in male Syrian hamsters despite its estrogenic potency, which is comparable to that of estradiol. 4-Fluoroestradiol, also a potent estrogen, did induce renal clear-cell carcinoma in this animal model, but more slowly than estradiol. 2,4-Dideuterioestradiol was found to be as estrogenic and also as carcinogenic as estradiol itself.
D000230:Adenocarcinoma / Q000139:chemically induced; D000818:Animals; D006224:Cricetinae; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D007680:Kidney Neoplasms / Q000139:chemically induced; D008297:Male; D008647:Mesocricetus; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000187:drug effects; D014599:Uterus / Q000187:drug effects
C037475:2-fluoroestradiol; D004958:Estradiol