Increased androgen binding in keloids: a preliminary communication.
Sex hormone binding protein analyses were performed on six keloids, the adjacent skin, and on six simple scars. A high level of androgen binding (510 to 1149 Fm/mg of cytosol protein) was found in the keloids. The estrogen and progesterone binding activities were low. Para-keloid tissues were found to have androgen binding of 177 to 476 Fm/mg of cytosol protein. Once again, estrogen and progesterone binding activities were low. In six simple scars, androgen binding was less than 1/10 of that found in the keloids (37 to 60 Fm/mg of cytosol protein); estrogen and progesterone binding was so low that it was almost undetectable. We believe this data suggests that localized hyperandrogen metabolism may play a causal or at least contributory role in the pathogenesis of keloids.
D000328:Adult; D000727:Androgen-Binding Protein / Q000032:analysis*; D002352:Carrier Proteins / Q000032:analysis*; D003600:Cytosol / Q000378:metabolism; D013196:Dihydrotestosterone / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism; D005260:Female; D006801:Humans; D007627:Keloid / Q000209:etiology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011397:Promegestone / Q000378:metabolism
D000727:Androgen-Binding Protein; D002352:Carrier Proteins; D013196:Dihydrotestosterone; D004958:Estradiol; D011397:Promegestone