[Effect of allyl isothiocyanate on cytochrome P-450 of rat liver microsomes].
The thrice-repeated oral administration of graded doses (50, 100 and 150 mg/kg of body mass) of allyl mustard oil to rats resulted in a decrease of the cytochrome P-450 and cytochrome b5 contents of the liver microsomes. There occurred a dose-dependent increase in mass of this organ.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003573:Cytochrome b Group / Q000378:metabolism; D015786:Cytochromes b5; D004305:Dose-Response Relationship, Drug; D017879:Isothiocyanates; D008099:Liver / Q000033:anatomy & histology; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013861:Thiocyanates / Q000008:administration & dosage* / Q000633:toxicity
D003573:Cytochrome b Group; D017879:Isothiocyanates; D013861:Thiocyanates; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; C004471:allyl isothiocyanate
Einfluss von Allylisothiocyanat auf Cytochrom P-450 von Rattenlebermikrosomen.