Uterine venous, peripheral venous, and radial arterial levels of prostaglandins E and F in women with pregnancy-induced hypertension.
Patients with pregnancy-induced hypertension have higher prostaglandin (PG) F concentrations in radial arterial blood (0.39 +/- 0.03 ng/ml) than control subjects (0.24 +/- 0.03 ng/ml) and higher (PGE plus PGF) concentrations in uterine venous blood obtained at the time of cesarean section (1.62 +/- 0.18 versus 1.03 +/- 0.12 ng/ml in the control group). The present results suggest that both PGE and PGF production by the uterus in patients with pregnancy-induced hypertension is increased but that catabolism of PGF by the lung is compromised; this permits larger quantities of the vasoconstrictor PG to pass into the systemic circulation, where it may cause hypertension directly or indirectly, by association with other vasoactive substances.
D000527:Alprostadil / Q000031:analogs & derivatives*; D001158:Arteries; D002585:Cesarean Section; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007743:Labor, Obstetric; D008168:Lung / Q000098:blood supply / Q000378:metabolism; D010920:Placenta / Q000502:physiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood*; D011458:Prostaglandins E / Q000096:biosynthesis / Q000097:blood*; D011460:Prostaglandins F / Q000096:biosynthesis / Q000097:blood*; D014599:Uterus / Q000098:blood supply / Q000378:metabolism; D014680:Veins
D011458:Prostaglandins E; D011460:Prostaglandins F; C022950:6-ketoprostaglandin E1; D000527:Alprostadil