title: Pilot study on the absolute and relative bioavailability of Synthroid and Levothroid, two brands of sodium levothyroxine.
abstract: The absolute and relative bioavailability of levothyroxine was determined in young, healthy male subjects after administration of i.v. solution, p.o. solution, or one of two brand-name, commercially available tablets. The mean dose size was about 0.18 mg. Serum concentration-time data were obtained over a period of 50 h. The absolute bioavailabilities of the two tablet preparations were 66% and 72%, respectively.
mesh_terms: D000293:Adolescent; D000328:Adult; D001682:Biological Availability; D006801:Humans; D008297:Male; D010865:Pilot Projects; D013607:Tablets; D013974:Thyroxine / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism
chemical_list: D013607:Tablets; D013974:Thyroxine