The treatment of experimental schistosomiasis with a combination of oxamniquine and praziquantel.
The object of the study was to identify any potential therapeutic advantage in using the two antischistosomal drugs, oxamniquine and praziquantel, in combination rather than separately, in the treatment of schistosomiasis. The efficacy of the drugs was studied in albino mice with mature Schistosoma mansoni infections. It was found that the efficacy of combinations of the two drugs was markedly superior to that expected on the basis of a simple additive effect. The significance of this synergistic action is discussed in the context of schistosomiasis therapy in man.
D000818:Animals; D004338:Drug Combinations; D004357:Drug Synergism; D005260:Female; D007546:Isoquinolines / Q000627:therapeutic use*; D051379:Mice; D008815:Mice, Inbred Strains; D009600:Nitroquinolines / Q000627:therapeutic use*; D010073:Oxamniquine / Q000627:therapeutic use*; D011223:Praziquantel / Q000627:therapeutic use*; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000188:drug therapy*
D004338:Drug Combinations; D007546:Isoquinolines; D009600:Nitroquinolines; D010073:Oxamniquine; D011223:Praziquantel