Anticoccidial activity of 1-phenyluracils.
The minimum effective concentration (MEC) of 6-azauracil against Eimeria tenella when incorporated in feed is about 1000 ppm. Attachment of suitably substituted phenyl side chains at the 1-position reduces the MEC to less than 1 ppm. Uracil itself is devoid of anticoccidial activity, but side chains attached at the 1-position potentiate uracil and result in activity against E. tenella. Although effective at levels as low as 60 ppm, the 1-phenyluracils are less active than the corresponding 1-phenyl-6-azauracils. They also are less acidic.
D000818:Animals; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy*; D004539:Eimeria / Q000187:drug effects; D007202:Indicators and Reagents; D013329:Structure-Activity Relationship; D014498:Uracil / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D007202:Indicators and Reagents; C038582:1-phenyluracil; D014498:Uracil