[Effect of doxycycline and isoconazole nitrate on human intestinal fungal flora].
29 patients from an outpatient department for pulmonary diseases were treated in randomized order with both doxycycline alone and in combination with 1-(2,4-dichloro-beta-(2,6-dichlorobenzyloxy)-phenethyl)-imidazole nitrate (isoconazole nitrate, Gyno-Travogen) 300 mg/day as well as 600 mg/day for 14 days. In 15 of the 29 patients, it was possible to detect Candida albicans in the stool before the beginning of therapy 10 patients being on a cortisone therapy with an average duration of 32.9 months. Under doxycycline monotherapy, a proliferation of the human intestinal flora by yeast-spp. did not occur. Furthermore, it was not possible to detect an effect of isoconazole nitrate on the human fecal intestinal flora.
D000328:Adult; D000368:Aged; D004318:Doxycycline / Q000009:adverse effects / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D005243:Feces / Q000382:microbiology; D005260:Female; D005658:Fungi / Q000187:drug effects*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D007422:Intestines / Q000382:microbiology*; D008297:Male; D008825:Miconazole / Q000009:adverse effects / Q000031:analogs & derivatives / Q000494:pharmacology*; D008875:Middle Aged
D007093:Imidazoles; D008825:Miconazole; C020382:isoconazole; D004318:Doxycycline
Einfluss von Doxycyclin und Isoconazolnitrat auf die intestinale Pilzflora des Menschen.