Anti-spasmogenic effect of cyproheptadine on guinea-pig ileum.
Antagonistic activity of cyproheptadine against common spasmogens, like acetylcholine, histamine, serotonin, bradykinin and angiotensin, was studied on isolated guinea-pig ileum. Cyproheptadine produced a reversible antagonism of non-competitive type and was most effective against serotonin. It was less potent against histamine, bradykinin and angiotensin and least potent against acetylcholine.
D000109:Acetylcholine / Q000037:antagonists & inhibitors*; D000804:Angiotensin II / Q000037:antagonists & inhibitors; D000818:Animals; D001920:Bradykinin / Q000037:antagonists & inhibitors*; D003533:Cyproheptadine / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006633:Histamine Antagonists; D007082:Ileum; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D012702:Serotonin Antagonists
D006633:Histamine Antagonists; D012702:Serotonin Antagonists; D000804:Angiotensin II; D003533:Cyproheptadine; D000109:Acetylcholine; D001920:Bradykinin