title: [Propafenon and alcohol: effect of this combination of behavioral performance and the subjective condition in healthy volunteers].
abstract: A double-blind cross-over study was carried out in ten healthy volunteers to investigate whether there was possible propafenone (Rytmonorm) interaction with alcohol and whether series propafenone produced EEG changes. For this a series of performance variables and two rating scales describing subjective condition (EWL, Bf-S) were used. In addition the volunteers described spontaneously the undesired effects with their own verbal concepts. Under all conditions of the trial no systematic EEG changes were found. The propafenone-alcohol combination effect was not different from the placebo-alcohol effects. Only the flicker fusion frequency (CFF) measurements yielded systematic changes. The CFF was decreased at the termination of the investigation compared with the beginning. However, these effects were similar under both propafenone and placebo and did not differ statistically significantly from each other. Thus, these effects could not be caused by propafenone.
mesh_terms: D000328:Adult; D004311:Double-Blind Method; D004347:Drug Interactions; D004569:Electroencephalography; D004644:Emotions / Q000187:drug effects*; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005260:Female; D005425:Flicker Fusion / Q000187:drug effects; D006801:Humans; D008297:Male; D011405:Propafenone; D011427:Propiophenones / Q000494:pharmacology*; D011597:Psychomotor Performance / Q000187:drug effects*; D014202:Tremor / Q000139:chemically induced
chemical_list: D011427:Propiophenones; D000431:Ethanol; D011405:Propafenone
vernacular_title: Propafenon und Alkohol: Einfluss dieser Kombinationauf das Leistungsverhalten und die subjektive Befindlichkeit bei gesunden Freiwilligen.