[Effect of bromfenvinphos (IPO-62) on changes in the apical dendritic spines of the cortical pyramidal neurons of the rat].
The rats (control group--6 animals, experimental group I--13, experimental group II--8) of inbred Wistar/W Bog strain, were orally administered 84,6% technical concentrate IPO-62 (bromphenvinphose) dissolved in olive oil and next the spines on apical cortex dendrites were evaluated. Statistically significant loss of dendritic spines was found both in group I (IPO-62 daily dose from 3 to 12 mg per 1 kg of body weight during 58 days) and in group II (IPO-62 daily dose--12 mg per 1 kg/body weight for 5 days and 18 mg/kg body weight for 4 days).
D000818:Animals; D001699:Biometry; D002709:Chlorfenvinphos / Q000031:analogs & derivatives / Q000633:toxicity*; D003712:Dendrites / Q000187:drug effects / Q000648:ultrastructure*; D005260:Female; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D010296:Parietal Lobe / Q000187:drug effects / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains
D007306:Insecticides; C014369:bromfenvinphos; D002709:Chlorfenvinphos
Zachowanie sie kolców na dendrytach szczytowych neuronów piramidowych kory u szczurów poddanych działaniu bromfenwinfosu (IPO-62).