title: Computed tomographic and nuclear magnetic resonance correlation of canine ceroid-lipofuscinosis with aging.
abstract: Canine ceroid lipofuscinosis is a degenerative neuronal disorder which has as a distinct pathologic counterpart, neuronal ceroid lipofuscinosis or Batten's disease in humans. The disease occurs in English setters and is associated with abnormal accumulation of autofluorescent lipopigments. As such, a study of this animal model may allow insight into the aging process as well. This investigation explores the computed tomographic features of canine ceroid-lipofuscinosis and correlates these findings (progressive atrophy, inherent changes in CT/NMR tissue characteristics) with clinical and pathologic features.
mesh_terms: D000818:Animals; D001284:Atrophy; D002552:Cerebral Ventricles / Q000473:pathology; D004195:Disease Models, Animal; D004285:Dogs; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D009472:Neuronal Ceroid-Lipofuscinoses / Q000473:pathology*; D010296:Parietal Lobe / Q000473:pathology; D014057:Tomography, X-Ray Computed