Selective inhibition by ketanserin and spiroperidol of 5-HT-induced myometrial contraction.
The inhibitory effects of ketanserin and spiroperidol (a neuroleptic drug) on the contractile response of isolated rat uterus to serotonin (5-HT) were investigated. Ketanserin caused non-competitive inhibition of the contractile response to 5-HT and showed more selective inhibition than the other 5-HT antagonists tested. The inhibitory effect of spiroperidol was comparable with the effects of classical 5-HT antagonists. These results suggest that ketanserin and spiroperidol selectively inhibit the contractile response of isolated rat uterus to 5-HT.
D000818:Animals; D002090:Butyrophenones / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D007650:Ketanserin; D010053:Ovary / Q000502:physiology; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013134:Spiperone / Q000494:pharmacology*; D014590:Uterine Contraction / Q000187:drug effects*
D002090:Butyrophenones; D010880:Piperidines; D012702:Serotonin Antagonists; D004958:Estradiol; D013134:Spiperone; D007650:Ketanserin