The appearance of an IgD-like molecule on pig lymphocytes during ontogeny.
An IgD-like molecule was found on the surface of pig fetal lymphocytes using guinea pig anti-human IgD antisera and indirect immunofluorescence. The binding of antiIgD antisera could be specifically inhibited with human IgD. Surface IgD-like molecules were found later in ontogeny than surface IgM (after about 70 d of gestation in the spleen). There is evidence for their endogenous origin. The number of lymphocytes bearing IgD-like molecules rapidly increased during ontogeny.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology; D005333:Fetus / Q000276:immunology; D007072:Immunoglobulin D / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis; D008214:Lymphocytes / Q000276:immunology*; D013552:Swine; D013556:Swine, Miniature / Q000196:embryology / Q000276:immunology*
D007072:Immunoglobulin D; D007075:Immunoglobulin M