Pattern reversal and flash evoked potentials following acute triethyltin exposure.
Until recently, pattern reversal visual evoked potentials (PREPs) had not been used to examine effects of neurotoxic agents, despite their clinical utility. Acute exposure to triethyltin (TET), which produces cerebral edema and myelin splitting, increased flash evoked potential (FEP) latencies in previous reports [17,18]. We recorded PREPs and FEPs in adult Long-Evans hooded rats before, and 24 hr after, exposure to 0, 4.5 or 6.0 mg/kg IP of TET bromide. Significant increases in latency and changes in amplitude of PREP peaks were found in the 6 mg/kg rats. FEP peak latency increases did not meet the criterion for statistical significance. Thus, under the conditions recorded, PREPs were better than FEPs as a measure of TET-induced neurotoxicity.
D000818:Animals; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D008297:Male; D009422:Nervous System Diseases / Q000139:chemically induced* / Q000175:diagnosis; D051381:Rats; D011930:Reaction Time / Q000187:drug effects; D014220:Trialkyltin Compounds / Q000633:toxicity*; D014267:Triethyltin Compounds / Q000633:toxicity*; D014795:Visual Pathways / Q000187:drug effects
D014220:Trialkyltin Compounds; D014267:Triethyltin Compounds; C031575:triethyltin