The effect of stasis on a microvascular anastomosis.
An experiment was done in rats to determine the effect of stopping the flow of blood across a fresh anastomosis. It was found that brief periods of stasis, up to 30 minutes, caused a minimal increase in the rate of thrombosis, but 60 minutes of stasis caused a significant risk of thrombosis in both arteries and veins. The thrombosis associated with stasis could be prevented by the systemic administration of heparin.
D000818:Animals; D001166:Arteriovenous Shunt, Surgical / Q000009:adverse effects*; D003250:Constriction; D005263:Femoral Artery / Q000601:surgery; D005268:Femoral Vein / Q000601:surgery; D006488:Hemostasis, Surgical / Q000009:adverse effects*; D006493:Heparin / Q000627:therapeutic use; D008866:Microsurgery / Q000009:adverse effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow; D013927:Thrombosis / Q000209:etiology* / Q000517:prevention & control; D013997:Time Factors; D014111:Tourniquets / Q000009:adverse effects
D006493:Heparin