title: Michael-type reactions of tenulin, a biologically active sesquiterpene lactone.
abstract: The antitumor pseudoguaianolide tenulin has been exposed to a wide variety of biological and model nucleophilic reagents and has been shown to react exclusively with sulfur nucleophiles in a Michael-like fashion. The biological implications of these results are discussed.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D012717:Sesquiterpenes; D013056:Spectrophotometry, Ultraviolet
chemical_list: D012717:Sesquiterpenes; C011124:tenulin