The effect of dopamine on L-fucose incorporation into hippocampal and striatal slices of dopamine-supersensitive rats.
The incorporation of L-[1-3H]fucose into total proteins was measured in hippocampal and striatal slices of dopamine-supersensitive and control rats. Compared with controls, striatal slices of supersensitive animals exhibited an augmented stimulation of L-fucose incorporation by 5 X 10(-5) M dopamine. This result supports former data about a dopamine-receptor mediated regulation of protein glycosylation in the nervous tissue.
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000494:pharmacology*; D005643:Fucose / Q000378:metabolism*; D006023:Glycoproteins / Q000096:biosynthesis*; D006220:Haloperidol / Q000494:pharmacology; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011922:Rats, Mutant Strains; D013239:Stereotyped Behavior / Q000187:drug effects; D014316:Tritium
D006023:Glycoproteins; D014316:Tritium; D005643:Fucose; D006220:Haloperidol; D004298:Dopamine