3-Methoxy-5,7,3',4'-tetrahydroxyflavan (ME): a new compound to prevent gastric irritation. A gastric potential difference analysis.
The protective effect of 3-Methoxy-5,7,3',4'-tetrahydroxyflavan (ME) on the gastric irritation induced by aspirin has been established using the non-invasive method of determination of the gastric potential difference (GPD) in male volunteers. 500 mg and 1000 mg ME (approx. 6.0-16.7 mg/kg b.w.) showed protective activity against induced gastric irritation in this model. The possible mechanism of action of this agent is discussed.
D001241:Aspirin / Q000037:antagonists & inhibitors; D002392:Catechin / Q000031:analogs & derivatives; D004305:Dose-Response Relationship, Drug; D005419:Flavonoids / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000187:drug effects*; D006801:Humans; D007509:Irritants / Q000037:antagonists & inhibitors; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D011897:Random Allocation; D013272:Stomach Diseases / Q000517:prevention & control*
D005419:Flavonoids; D007509:Irritants; C029339:meciadanol; D002392:Catechin; D001241:Aspirin