The anxiogenic action of Ro 5-4864 is reversed by phenytoin.
Ro 5-4864, a selective ligand for the benzodiazepine micromolar and peripheral receptors, had a significant dose-related (5-20 mg/kg) anxiogenic action in the social interaction test of anxiety. This anxiogenic effect was reversed by phenytoin (10 mg/kg), a ligand for the micromolar receptors, but unaffected by the isoquinoline PK 11195 (10 mg/kg), a ligand for the peripheral receptors.
D000818:Animals; D001007:Anxiety / Q000139:chemically induced*; D001570:Benzodiazepinones / Q000037:antagonists & inhibitors*; D006801:Humans; D007398:Interpersonal Relations; D007546:Isoquinolines / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010672:Phenytoin / Q000494:pharmacology*; D051381:Rats
D001570:Benzodiazepinones; D007546:Isoquinolines; C028513:4'-chlorodiazepam; D010672:Phenytoin; C037850:PK 11195