title: Mass spectral investigation of the metabolites of lorcainide in man.
abstract: [3H] Lorcainide hydrochloride was administered orally to healthy male volunteers. About 97% of the total radioactivity was excreted in the urine and faeces within four days of its administration. The metabolites were purified by adsorption chromatography, liquid-liquid extraction, thin layer chromatography or by gas chromatography-mass spectrometry after silylation of the samples. When there was a sufficient amount available, the samples were submitted to a nuclear magnetic resonance analysis. The results were confirmed by comparison of spectral data obtained from the reference compounds. The major metabolites of lorcainide were formed by aromatic hydroxylation, O-methylation and oxidative N-dealkylation. The urinary phenolic metabolites were present both as free aglycons and conjugates.
mesh_terms: D044482:Benzeneacetamides; D001711:Biotransformation; D002845:Chromatography / Q000379:methods; D003640:Dealkylation; D005243:Feces / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006900:Hydroxylation; D008297:Male; D008745:Methylation; D010084:Oxidation-Reduction; D010880:Piperidines / Q000378:metabolism* / Q000652:urine
chemical_list: D044482:Benzeneacetamides; D010880:Piperidines; C015970:lorcainide