The influence of 2-(4-methylaminobutoxy)diphenylmethane hydrochloride (MCI-2016) on gastric ulcer and gastric acid secretion.
The effect of 2-(4-methylaminobtoxy)diphenylmethane hydrochloride (MCI-2016) on the development of ulcers and on gastric secretion were examined in comparison with imipramine and amitriptyline. In various experimental ulcer models (Shay, water-immersion restraint, cold stress, swimming stress and reserpine ulcers), MCI-2016, at the doses ranging from 6.25 to 100 mg/kg p.o., exhibited a dose-dependent inhibition of ulceration with high therapeutic index. MCI-2016 showed little influence on the spontaneous and stimulated gastric secretion at the doses effectively suppressing the ulcer formation. In contrast, both imipramine and amitriptyline caused a significant inhibition of spontaneous and carbachol-stimulated gastric secretion. These results suggest that anti-cholinergic action is not involved in the anti-ulcer effect of MCI-2016. It may be further postulated that central norepinephrine (noradrenaline) uptake inhibition is related with the anti-ulcer action of MCI-2016.
D000818:Animals; D000897:Anti-Ulcer Agents; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D003080:Cold Temperature; D005744:Gastric Acid / Q000378:metabolism*; D008297:Male; D011708:Pylorus / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000139:chemically induced / Q000517:prevention & control; D013550:Swimming
D000897:Anti-Ulcer Agents; D001559:Benzhydryl Compounds; D012110:Reserpine; C031906:bifemelane