title: Clinical pharmacokinetics of furosemide in children with nephrotic syndrome.
abstract: The pharmacokinetic disposition of furosemide has been investigated in seven children with nephrotic syndrome and in eight control children. Furosemide in plasma was analyzed by spectrofluorometry. After a single intravenous dose of furosemide (1 mg/kg body wt.) the nephrotic children showed lower initial plasma concentrations because of the larger volume of distribution. The mean half-life of furosemide in nephrotic children (38.5 +/- 7.8 min) was significantly longer than in the control group (28.0 +/- 7.7 min). The two groups did not differ in the body clearance of total furosemide. The average serum clearance was 4.95 +/- 1.7 ml/min/kg body wt. in the control group and 5.10 +/- 1.4 ml/min/kg body wt. in the nephrotic children. There was a significant reduction in urine sodium and distribution volume, whereas potassium excretion remained unchanged.
mesh_terms: D002675:Child, Preschool; D005260:Female; D005665:Furosemide / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000378:metabolism; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine; D013997:Time Factors
chemical_list: D005665:Furosemide; D012964:Sodium; D011188:Potassium