Plasma lipid-lowering action of ginseng saponins and mechanism of the action.
Elevation of plasma levels of cholesterol and triglyceride was reduced by the intramuscular injection of ginseng principles fraction 4 (saponin content, ca. 1/2). The elimination of intraperitoneally injected 4-[14C]-cholesterol from plasma was accelerated by fraction 4 administration. Fecal excretion [14C]bile acids and [14C]sterols after intraperitoneal injection of 4-[14C]-cholesterol was significantly increased by fraction 4 administration.
D000818:Animals; D001711:Biotransformation; D002784:Cholesterol / Q000378:metabolism; D008055:Lipids / Q000097:blood*; D008297:Male; D005894:Panax; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains; D012503:Saponins / Q000494:pharmacology*
D008055:Lipids; D012503:Saponins; D002784:Cholesterol