Chemical synthesis of nucleotide oligomers: convergent synthesis of fully protected 80mer of thymidylic acid.
Synthesis of fully protected polythymidylic acids of definite lengths was carried out in solution. Decamer(T10), eicosamer(T20), tetracontamer (T40) and octacontamer(T80) were obtained in 80, 83, 75 and 52% yields respectively by a strategy of convergent synthesis.
D055598:Chemical Phenomena; D002621:Chemistry; D009841:Oligonucleotides / Q000138:chemical synthesis*; D011071:Poly T / Q000138:chemical synthesis*; D011089:Polydeoxyribonucleotides / Q000138:chemical synthesis*
D009841:Oligonucleotides; D011089:Polydeoxyribonucleotides; D011071:Poly T