[Effect of phenazepam and seduxen on the presence of histidase and urokinase in the blood].
Liver tissue specific enzymes histidase and urokinase were found in blood of 160 rats after intraperitoneal administration of phenazepam at the doses of 1.0 and 2.5 mg/200 g of body weight as well as of diazepam at the dose of 2.0 mg/200 g. Administration of products of diazepam enzymatic degradation caused also the liberation of these enzymes from liver tissue into blood.
D000642:Ammonia-Lyases / Q000097:blood*; D000818:Animals; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000008:administration & dosage / Q000378:metabolism*; D003975:Diazepam / Q000008:administration & dosage / Q000378:metabolism*; D006638:Histidine Ammonia-Lyase / Q000097:blood*; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; D014568:Urokinase-Type Plasminogen Activator; D000642:Ammonia-Lyases; D006638:Histidine Ammonia-Lyase; D003975:Diazepam
Vliianie fenazepama i seduksena na poiavlenie v krovi gistidazy i urokaninazy.