[Inhibition of natural killer activity in emotional stress and elimination of this phenomenon by interferon inducer].
The authors provide the data on the effect of emotional painful stress (EPS) of varying duration on the activity of natural killers (NK) of August rats' spleen 1 to 9 days after exposure to stress is discontinued. The activity of NK was tested against target cells K 562 labeled with 51Cr in a 14-hour test. The effect of stress was found to depend on the duration of the stressor reaction. 1 1/2- and 3-hour stress activated NK, while prolonged 6-hour stress suppressed the activity of natural killers within the first 2 days, followed by the recovery by day 7-9 of the activity of lymphocytes having natural cytotoxicity. Tiloron, a synthetic inducer of endogenous interferon, corrected the post-stressor depression of NK activity.
D000818:Animals; D006801:Humans; D007165:Immunosuppression Therapy; D007369:Interferon Inducers / Q000494:pharmacology*; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D051381:Rats; D013315:Stress, Psychological / Q000276:immunology*; D013994:Tilorone / Q000494:pharmacology; D013997:Time Factors
D007369:Interferon Inducers; D013994:Tilorone
Podavlenie aktivnosti normal'nykh killerov pri émotsional'no-bolevom stresse i ustranenie étogo iavleniia induktorom interferona.