Lack of inhibition by oxipurinol of 5-FU toxicity against human tumor cell lines.
Allopurinol has been reported to decrease the gastrointestinal and bone marrow toxicity of 5-FU when administered in a high dose by continuous infusion. The effect of oxipurinol, the major metabolite of allopurinol, on 5-FU cytotoxicity against three human tumor cell lines was studied using a soft agar clonogenic assay. For both WiDR (colon) and T-47 (breast), 5-FU cytotoxicity was greater in the presence of oxipurinol than in its absence. Oxipurinol did not significantly affect 5-FU cytotoxicity against Hec-1A (endometrial). In none of the three lines was a protective effect of oxipurinol noted.
D001943:Breast Neoplasms / Q000188:drug therapy*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D010117:Oxypurinol / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D014594:Uterine Neoplasms / Q000188:drug therapy*
D011743:Pyrimidines; D010117:Oxypurinol; D005472:Fluorouracil