title: Potential for genetic damage from multivitamin solutions exposed to phototherapy illumination.
abstract: The ability of standard phototherapy illumination to produce damage in intracellular DNA is well established. In this study, the addition of a dilute solution (1:6400) of a clinically-used multivitamin concentrate to human KB cells was found to enhance the generation of single-strand DNA breaks produced by broad-spectrum fluorescent light. The effect of the exogenous photosensitizing agent (multivitamins) was blocked by the enzyme catalase; thus, the photoproduct responsible for the DNA modification was hydrogen peroxide, an extremely reactive molecule capable of damaging a variety of biologic macromolecules.
mesh_terms: D002374:Catalase / Q000494:pharmacology; D004247:DNA / Q000235:genetics / Q000528:radiation effects*; D006801:Humans; D066298:In Vitro Techniques; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000628:therapy; D010789:Phototherapy / Q000009:adverse effects*; D012996:Solutions; D014815:Vitamins / Q000009:adverse effects / Q000528:radiation effects*
chemical_list: D012996:Solutions; D014815:Vitamins; D004247:DNA; D002374:Catalase