Computer modelling of the binding of non-selective ligands to biological receptors.
The application of common linearization methods (log-probit analysis or Hill plot transformation) to the evaluation of receptor binding experiments leads to serious errors, if the ligands used possess insufficient receptor selectivity. The use of simultaneous non-linear curve-fitting procedures in this case is recommended and illustrated.
D001665:Binding Sites; D003201:Computers; D007700:Kinetics; D008024:Ligands; D008954:Models, Biological; D011955:Receptors, Drug / Q000378:metabolism*
D008024:Ligands; D011955:Receptors, Drug