title: Evaluation of 99mTc-dichloro bis (1,2-dimethylphosphino) ethane (99mTc-DMPE) for myocardial scintigraphy in man.
abstract: 99mTc-DMPE was used for myocardial scintigraphy in ten patients with coronary artery disease. As in 201T1 studies regional activity of 99mTc-DMPE was reduced in infarcted myocardium. However, activity accumulation of 99mTc-DMPE in the heart was faint, while that in the liver was prominent. The activity ratio of heart to liver improved with time, whereas that of heart to lung decreased. The scintigraphic quality was considerably worse in 99mTc-DMPE studies than in those with 201Tl, due to high background activity. Also the visualization of the ribs and sternum interfered with the interpretation of the scintigrams. From these results it appears that 201Tl remains still the agent of choice for myocardial perfusion scintigraphy.
mesh_terms: D003327:Coronary Disease / Q000000981:diagnostic imaging*; D006801:Humans; D015609:Organotechnetium Compounds; D010720:Phosphines; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013667:Technetium; D013793:Thallium
chemical_list: D015609:Organotechnetium Compounds; D010720:Phosphines; D011868:Radioisotopes; D013667:Technetium; C031898:technetium Tc 99m bis(1,2-dimethylphosphino)ethane; D013793:Thallium