Comparison of 2'-fluoro-arabinosyl pyrimidine nucleosides and 1-beta-D-arabinofuranosylcytosine on immunological parameters in vitro.
1-beta-D-arabinofuranosylcytosine (ara C)3, 2'-fluoro-5-iodo-arabinofuranosyl-cytosine (FIAC) and 2'-fluoro-5-methyl-arabinofuranosyluracil (FMAU) were analyzed for immunosuppressive activity in vitro. In assay systems quantifying both humoral and cellular immune reactivity, FMAU and FIAC were less immunosuppressive than ara C by several orders of magnitude.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000187:drug effects*; D001086:Arabinofuranosyluracil / Q000031:analogs & derivatives* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D003561:Cytarabine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007108:Immune Tolerance / Q000187:drug effects; D051379:Mice; D013154:Spleen / Q000276:immunology; D014529:Uridine / Q000031:analogs & derivatives*
D003561:Cytarabine; D001086:Arabinofuranosyluracil; C026023:fiacitabine; C034935:clevudine; D014529:Uridine