Hyaline membrane disease treated with bovine surfactant.
Six preterm infants with severe hyaline membrane disease requiring ventilation were treated, at a median age of 15.5 hours, with a single intratracheal bolus of a bovine surfactant suspension. Arterial oxygenation increased dramatically, and chest radiograms showed improvement after two to four hours. However, a variable degree of deterioration occurred within 24 hours. All of the infants required oxygen therapy for several weeks, and one developed severe bronchopulmonary dysplasia.
D000818:Animals; D002543:Cerebral Hemorrhage / Q000150:complications; D005260:Female; D006801:Humans; D006819:Hyaline Membrane Disease / Q000150:complications / Q000188:drug therapy*; D007231:Infant, Newborn; D008297:Male; D010100:Oxygen / Q000097:blood; D011663:Pulmonary Surfactants / Q000008:administration & dosage / Q000627:therapeutic use*; D012121:Respiration, Artificial; D013552:Swine
D011663:Pulmonary Surfactants; D010100:Oxygen