Amnesia attenuation specificity: propranolol reverses norepinephrine but not cycloheximide-induced amnesia.
Post-trial injections of norepinephrine (NE) or cycloheximide (CHX) into the amygdala produces a long-term retention deficity (amnesia) for a 1-trial footshock experience in rats. concomitant post-trial injections of the adrenergic antagonist, propranolol, prevents NE-, but not CHX-induced amnesia. These results indicate separate mechanisms of action for amnesia produced by intracranial CHX and NE injections.
D000647:Amnesia / Q000139:chemically induced*; D000648:Amnesia, Retrograde / Q000139:chemically induced* / Q000503:physiopathology; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003513:Cycloheximide / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology* / Q000502:physiology; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D011930:Reaction Time / Q000187:drug effects
D003513:Cycloheximide; D011433:Propranolol; D009638:Norepinephrine