In vivo amplification and rearrangement of the c-Ha-ras-1 sequence in a human bladder carcinoma.
Southern blot analyses revealed amplification and rearrangement of c-Ha-ras-1 sequence in the DNA of one biopsied specimen of bladder carcinoma. DNA from normal cells, leukocytes, of the same patient showed no such changes. Therefore, the amplification and rearrangement described here seem to be associated with the development of the cancer.
D004247:DNA / Q000032:analysis / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis / Q000235:genetics*; D004587:Electrophoresis, Agar Gel; D005784:Gene Amplification; D005814:Genes, Viral; D006251:Harvey murine sarcoma virus / Q000235:genetics; D006801:Humans; D007962:Leukocytes / Q000032:analysis; D008970:Molecular Weight; D009857:Oncogenes; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
D004273:DNA, Neoplasm; D004247:DNA