Stimulatory effects of prostaglandin F2 alpha on faecal egg production in Haemonchus contortus infected sheep.
The effect of prostaglandin F2 alpha on the pattern of faecal egg count was tested in 10- to 12-month-old sheep infected with 20,000 Haemonchus contortus larvae. Prostaglandin was infused intravenously 25, 50 and 75 days after infection for four hours at a rate of 5 micrograms/kg/minute and the egg counts in the faeces were determined daily for 110 days. Treatment on days 50 and 75 was followed by a significant rise in egg count lasting 19 and 12 days respectively. This observed rise seems to be related to a resumption of development of arrested larvae induced by prostaglandin treatment, and a hypothesis is proposed to explain its initiation.
D000818:Animals; D005243:Feces / Q000469:parasitology; D005260:Female; D006188:Haemonchiasis / Q000662:veterinary*; D006189:Haemonchus / Q000187:drug effects*; D010063:Ovum / Q000187:drug effects*; D010270:Parasite Egg Count; D011460:Prostaglandins F / Q000494:pharmacology*; D012756:Sheep; D012757:Sheep Diseases / Q000469:parasitology; D014251:Trichostrongyloidea / Q000187:drug effects*; D014252:Trichostrongyloidiasis / Q000662:veterinary*
D011460:Prostaglandins F