Nitroreduction of benznidazole and nifurtimox by rat and human feces.
Rat and human feces are able to reduce nitro group from Benznidazole (N-benzyl-2-nitro-1-imidazole acetamide) and Nifurtimox (4[5-nitrofurfurylidene)-amino)-3-methylthiomorpholine-1,1-dioxide), two chemotherapeutic agents against Chagas' disease. Feces from rats treated with neomycin sulfate lack nitroreductase activity evidencing the bacterial origin of the enzyme.
D000818:Animals; D005243:Feces / Q000032:analysis*; D006801:Humans; D008297:Male; D009355:Neomycin / Q000494:pharmacology; D009547:Nifurtimox / Q000378:metabolism*; D009574:Nitro Compounds / Q000378:metabolism*; D009581:Nitrofurans / Q000378:metabolism*; D009593:Nitroimidazoles / Q000378:metabolism*; D009601:Nitroreductases; D010084:Oxidation-Reduction; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity
D009574:Nitro Compounds; D009581:Nitrofurans; D009593:Nitroimidazoles; D010088:Oxidoreductases; D009601:Nitroreductases; D009355:Neomycin; D009547:Nifurtimox; C009999:benzonidazole