Effect of dietary supplementation with stearic acid on the severity of myocardial lesions.
Histological studies were conducted on ventricular myocardium obtained from male rats of the Sprague-Dawley strain after 16 weeks of feeding diets containing 20 per cent (w/w) soybean oil, low erucic acid rapeseed oil or high erucic acid rapeseed oil. Additional groups of rats were fed similar diets supplemented with up to 8 g/kg of tristearin. Increasing dietary intake of stearic acid normalised the plasma ratio of C16:0 to C18:0 for rapeseed oil treatments to ratios analogous to that observed for rats fed soybean oil. Tristearin supplementation did not have a significant effect on myocardial lesion incidence but decreased the severity of lesions observed for rapeseed oil treatments.
D000818:Animals; D001937:Brassica; D009202:Cardiomyopathies / Q000209:etiology / Q000473:pathology / Q000517:prevention & control*; D004041:Dietary Fats / Q000009:adverse effects*; D004883:Erucic Acids / Q000009:adverse effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013025:Glycine max / Q000009:adverse effects; D013229:Stearic Acids / Q000627:therapeutic use*
D004041:Dietary Fats; D004883:Erucic Acids; D013229:Stearic Acids