[Peculiarities of the recurrence of lymphogranulomatosis in children following combined chemotherapy].
The study was concerned with patterns of stage IV lymphogranulomatosis (Hodgkin's disease) recurrence as well as factors affecting it. A combined therapy relying mostly on MOPP scheme was used. Out of 109 children treated, primary complete remission was obtained in 78 (71.6%). However, remission continued throughout the study in 46 cases (59.0%) only. Relapse was more frequent (29 out of 32 cases) in the involved parts of the lymphatic system which had not been exposed to radiation during complete remission. The rate of recurrence formation was found to be in a significant correlation with general symptoms, age, size of the largest cluster of involved lymph nodes, combination of drugs and type of consolidating therapy.
D000367:Age Factors; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols; D002648:Child; D003520:Cyclophosphamide / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008466:Mechlorethamine / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use; D011344:Procarbazine / Q000627:therapeutic use; D012008:Recurrence; D014750:Vincristine / Q000627:therapeutic use
D000970:Antineoplastic Agents; D011344:Procarbazine; D008466:Mechlorethamine; D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone
Osobennosti retsidivirovaniia limfogranulematoza u deteĭ posle kombinirovannoĭ khimioterapii.