Some pharmacological and biochemical effects of fibrinopeptides A and B in the circulatory system of rats.
Human fibrinopeptides A and B (FAB) increased the arterial blood pressure, accelerated the heart rate and elevated permeability of capillaries, produced a vasodilatory effect, evoked positive chronotropic and inotropic action on the isolated heart and did not affect the coronary flow. They lowered the content of glycogen in the heart muscle. They did not affect the concentration of glucose and elevated the content of lactic acid and free fatty acids (FFA) in the blood. As FAB are present in large quantities in the blood during disseminated intravascular coagulation, they may play an essential role in pathology of the circulatory system of mammals.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D005340:Fibrinogen / Q000494:pharmacology*; D005344:Fibrinopeptide A / Q000494:pharmacology*; D005345:Fibrinopeptide B / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D005344:Fibrinopeptide A; D005345:Fibrinopeptide B; D005340:Fibrinogen