Evaluation of the chronic hepatic toxicity of 6-mercaptopurine in the wistar rat.
The ability of choline (C) to prevent hepatic toxicity due to chronic administration of 6-mercaptopurine (6-MP) was evaluated in male Wistar rats. Two dose levels of 6-MP and two dose levels of C were used. Choline did not prevent or diminish the hepatic accumulation of triglyceride when administered in combination with 6-MP. The 6-MP did impair the growth of the experimental animals, and this effect was antagonized by C administration. The data provided experimental support for the clinical observation of growth impairment in children treated with chronic antimetabolite therapy for acute lymphoblastic leukemia.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002794:Choline / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006128:Growth / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D015122:Mercaptopurine / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000378:metabolism
D014280:Triglycerides; D015122:Mercaptopurine; D002794:Choline