Inhibition in vitro of the polymerization of tubulin by uremic middle molecules: corrective effect of isaxonine.
The polymerization of tubulin leads to the formation of microtubules which are one of the components of the axons of nerve cells. This reaction is the limiting factor in the growth of axons. Uremic middle molecules inhibit in vitro the polymerization of tubulin in a dose dependent way. It is possible that a similar phenomenon could occur in vivo in uremic patients, and this might be involved in the development of neuropathy. In addition, isaxonine phosphate counteracts the inhibitory effect of uremic middle molecules on the polymerization of tubulin.
D000328:Adult; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008870:Microtubules; D008875:Middle Aged; D011108:Polymers; D011743:Pyrimidines; D014118:Toxins, Biological; D014404:Tubulin
D011108:Polymers; D011743:Pyrimidines; D014118:Toxins, Biological; D014404:Tubulin; C026865:uremia middle molecule toxins; C020375:isaxonine