title: Kainate resistant neurons in peripheral ganglia of the rat.
abstract: Neurons of dorsal root ganglia and of superior cervical ganglia did not display any morphological signs of degeneration when kainic acid (KA) was administered either systemically (20 and 40 mg/kg) or when it was directly injected (1 microgram). The KA doses used were sufficient to result in heavy destruction of hippocampal CA3/CA4 neurons and neurodegeneration of various brain regions after intracerebroventricular or local application, respectively. The resistance of the peripheral neurons to KA is discussed as a consequence of lacking glutamate inputs.
mesh_terms: D000818:Animals; D004351:Drug Resistance; D005727:Ganglia, Spinal / Q000187:drug effects / Q000502:physiology*; D005728:Ganglia, Sympathetic / Q000187:drug effects / Q000502:physiology*; D007608:Kainic Acid / Q000633:toxicity*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011759:Pyrrolidines / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D011759:Pyrrolidines; D007608:Kainic Acid