Synthesis of model compounds for the interaction between modified nucleic acid bases.
In order to study the stacking interaction of modified nucleic acid bases, which is assumed to be responsible for the anomalous thermostability of thermophile tRNA, several model compounds 1-6 are synthesized. On the basis of their hypochromicities, the interaction between bases are discussed.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006358:Hot Temperature; D008956:Models, Chemical; D009690:Nucleic Acid Conformation; D009696:Nucleic Acids; D011687:Purines; D011743:Pyrimidines; D013329:Structure-Activity Relationship
D009696:Nucleic Acids; D011687:Purines; D011743:Pyrimidines