[Construction, operation and initial experience with a laboratory apparatus for fluid-bed coating of particles].
Starting from the developmental work of Dittgen and co-workers [1] and of Gröning [2], the authors constructed an air-suspension device which permits to coat crystals, granules and pellets on a laboratory scale. The device developed is a glass apparatus for coating almost 10 g of particles. The motion of the particles to be coated is characterized by a high-speed rotation on a circular orbit associated with a raise by the air current and a fall caused by gravity. This combined motion prevents the development of zones of varying particle sizes. The usefulness of this apparatus is demonstrated by the example of the application of a polyacrylate depot coating to pholedrine sulphate and quinidine sulphate pellets. Scanning electron micrographs are used for the optical assessment of the coating.
D008694:Methamphetamine / Q000031:analogs & derivatives; D008855:Microscopy, Electron, Scanning; D010316:Particle Size; D011802:Quinidine; D013678:Technology, Pharmaceutical / Q000295:instrumentation*
D008694:Methamphetamine; C005877:pholedrine; D011802:Quinidine
Aufbau, Arbeitsweise und erste Erfahrungen mit einem Laborgerät zum Uberziehen von Partikeln in der Wirbelschicht.