title: Neonatal gastric perforations; a diagnostic clue in pre-perforative phase.
abstract: This paper is a retrospective analysis of the pre-perforative clinical picture in twenty-seven neonates with gastric perforations. In fifteen there was a remarkably consistent progressive pattern in the preperforative clinical course. We separated the clinical course of the disease into three distinct stages in relation to pathological changes in the gastric wall i.e. gastric ischemia and dysfunction, transmural peritonitis and paralytic ileus, and actual perforation. Emphasis was placed on the existance of a clinically detectable pre-perforative phase which, if interpreted correctly, should lead to earlier diagnosis and consequently more satisfactory therapeutic results.
mesh_terms: D006396:Hematemesis / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases; D007418:Intestinal Pseudo-Obstruction / Q000209:etiology; D010538:Peritonitis / Q000209:etiology; D011027:Pneumoperitoneum / Q000209:etiology; D012422:Rupture, Spontaneous; D013275:Stomach Rupture / Q000150:complications*