[Thyroid hormones and phospholipase activity in rat liver mitochondria].
The rate of the hydrolysis of mitochondrial phospholipids isolated from the liver of rats given excess amount of thyroid hormones for a long time was higher than in normal animals. Activation of this process determined by endogenous phospholipase of mitochondria could be also observed in liver mitochondria isolated 2 days after a single injection of L-thyroxine into rats. It is assumed that the hyperthyrosis-induced acceleration of lipid peroxidation in these organelles might be one of the reasons for activation of endogenous phospholipase of mitochondria.
D000818:Animals; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006980:Hyperthyroidism / Q000201:enzymology*; D008297:Male; D008930:Mitochondria, Liver / Q000201:enzymology*; D010740:Phospholipases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D005230:Fatty Acids, Nonesterified; D010740:Phospholipases
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