Cyanoketone competition with estradiol for binding to the cytosolic estrogen receptor.
Cyanoketone, an inhibitor of many steroidogenic processes, has been found to inhibit binding of estradiol to its receptor in a competitive manner. The Ki observed was 1.2 X 10(-6)M. This action may explain some of cyanoketone's effects in vivo.
D000737:Androstenols / Q000378:metabolism*; D000818:Animals; D001667:Binding, Competitive; D003489:Cyanoketone / Q000378:metabolism*; D003600:Cytosol / Q000378:metabolism; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D007700:Kinetics; D008297:Male; D010053:Ovary / Q000378:metabolism*; D011467:Prostate / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D011944:Receptors, Androgen / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism*; D014599:Uterus / Q000378:metabolism*
D000737:Androstenols; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D003489:Cyanoketone; D004958:Estradiol