Correlations between cell-cycle perturbations and survival levels after exposure to adriamycin for two Chinese hamster cell lines.
The cell-cycle perturbation and cell inactivation after adriamycin (ADR) exposure were measured in two Chinese hamster cell lines differing in ADR sensitivity. Based on DNA distribution analysis, it was found that the rate of G1 fraction depletion following low-dose ADR treatment was related to the level of cell inactivation. The results indicate that gross cellular sensitivity to ADR can be predicted rapidly by this approach.
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000494:pharmacology*; D007399:Interphase / Q000187:drug effects; D013997:Time Factors
D004317:Doxorubicin; D004247:DNA