A genetic component of the variance of N-acetoxy-2-acetylaminofluorene-induced DNA damage in mononuclear leukocytes determined by a twin study.
The level of N-acetoxy-2-acetylaminofluorene (NA-AAF)-induced unscheduled DNA synthesis and the level of covalent binding of NA-AAF to DNA were determined in the mononuclear leukocytes of monozygotic and diazygotic twin pairs (n = 16 for each type). A statistically significant high degree of heritability was calculated for both parameters which, in turn, indicate genetic control of individual levels of induced DNA damage by NA-AAF.
D015073:2-Acetylaminofluorene / Q000031:analogs & derivatives*; D000099:Acetoxyacetylaminofluorene / Q000633:toxicity*; D000328:Adult; D001794:Blood Pressure; D004247:DNA / Q000096:biosynthesis / Q000235:genetics*; D004261:DNA Replication / Q000187:drug effects*; D005260:Female; D014644:Genetic Variation; D006801:Humans; D007962:Leukocytes / Q000378:metabolism; D008297:Male; D011247:Pregnancy; D012907:Smoking; D014427:Twins; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic
D000099:Acetoxyacetylaminofluorene; D004247:DNA; D015073:2-Acetylaminofluorene