title: Natural history of healing in the repaired medial collateral ligament.
abstract: The purpose of this study was to assess morphologically the healing of repaired medial collateral ligaments (MCLs) in a rabbit model. Healing ligaments were examined grossly and histologically at various intervals, from 3 days to 2 1/2 years after injury, and compared with the appearances of normal age-, sex-, and activity-matched controls. Results show that all ligaments healed by bridging scar formation rather than true ligament regeneration. Increases in cellularity and temporary matrix disorganization along the entire length of the ligaments during healing suggest a combination of diffuse mechanical damage from their failure in tension and regional inflammatory injury (in excess of surgical exposure alone) from the processes of degradation and replacement. Substance that was not injured physically in this model demonstrated complete recovery, while that replaced by scar did not. Healing processes were similar to those of other highly specialized soft tissues (e.g., tendons), with short phases of hemorrhage and inflammation, an intermediate phase of proliferation, and a prolonged phase of remodeling. Failure of repairs to maintain anatomical apposition of torn ends may have contributed to the delay of these healing processes by increasing scar mass. Incomplete scar remodeling at 2 1/2 years, however, suggests much slower MCL healing than previously reported and probably, therefore, a longer period for potential treatment influence.
mesh_terms: D000818:Animals; D002921:Cicatrix / Q000473:pathology; D008023:Ligaments, Articular / Q000293:injuries / Q000473:pathology / Q000502:physiology*; D008297:Male; D011817:Rabbits; D013997:Time Factors; D014945:Wound Healing