Inhibition of morphine analgesia by ascorbate.
Oral administration of single doses of ascorbate produced a decrease in the analgesic effect of morphine in mice when assayed by the tail-flick test. Inhibition of analgesia was dose dependent, had a rapid onset (2 hr) and long duration (48 hr). Ascorbate doses over 8 mg/kg also protected mice from lethal doses of morphine. These findings are in accord with recent reports that ascorbate destroys opioid receptor in vitro and indicates that a similar effect occurs in vivo.
D000698:Analgesia; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000037:antagonists & inhibitors*; D011930:Reaction Time / Q000187:drug effects; D013623:Tail / Q000187:drug effects; D013997:Time Factors
D009020:Morphine; D001205:Ascorbic Acid