Fine specificity of the immune response to oxazolones III. Antibodies but not contact sensitivity specific for 2-furyloxazolone are controlled by an Igh-V gene in the mouse.
Early IgM and IgG antibodies of CBA and C3H mice (Igh allotype j) against furyloxazolone (furyl Ox) were found to be heteroclitic, they had a 4-6 times higher affinity for styryloxazolone (styryl Ox) than for furyloxazolone. Anti-furyl Ox antibodies of six other strains (Igh allotypes a, b, c, e, f or g) had approximately 100 times higher affinity for furyl Ox than for styryl Ox. The heteroclitic fine-specificity was inherited as an Igh allotype-linked trait. Furyl Ox-specific contact sensitivity was induced by painting, and its specificity was studied with a recently developed method (Ferreira et al., J. Immunol. 1981. 127:2366). Small strain differences in specificity were detected. They were not inherited as an Igh allotype-linked trait.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D005796:Genes / Q000187:drug effects*; D006241:Haptens; D006968:Hypersensitivity, Delayed; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D007074:Immunoglobulin G / Q000235:genetics*; D007075:Immunoglobulin M / Q000235:genetics*; D007700:Kinetics; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010080:Oxazoles; D010081:Oxazolone / Q000031:analogs & derivatives; D013045:Species Specificity; D013329:Structure-Activity Relationship
D006241:Haptens; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010080:Oxazoles; D010081:Oxazolone; C032541:2-furyl-4-ethoxymethylene-5-oxazolone; D003520:Cyclophosphamide; C040284:2-styryl-4-ethoxymethylene-5-oxazolone