title: A preliminary description of acute physical dependence on morphine in the vervet monkey.
abstract: Previous animal studies have suggested the rapid development of opiate dependency in 24 hours or less. However, the development of dependence on opioids within twenty-four hours has yet to be demonstrated in previously opiate-free human or nonhuman primate subjects. Following naloxone administration, cable-restrained monkeys which received intravenous morphine hourly for only six hours exhibited a behavioral syndrome characteristic of opioid withdrawal in this particular species. These data indicate that acute physical dependence on morphine may be induced after six hours in a primate species.
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002404:Catheterization; D002522:Chlorocebus aethiops; D006801:Humans; D008297:Male; D009020:Morphine / Q000008:administration & dosage; D009021:Morphine Dependence / Q000523:psychology*; D009270:Naloxone / Q000494:pharmacology; D009271:Naltrexone / Q000494:pharmacology; D013375:Substance Withdrawal Syndrome / Q000139:chemically induced
chemical_list: D009270:Naloxone; D009271:Naltrexone; D009020:Morphine