Clonidine (Haemiton) as a reliable stimulus of growth hormone secretion in patients with short stature.
In 14 patients with short stature aged 4-14 years the effect of clonidine has been investigated. A single oral dose of 0.15 mg/m2 surface area is followed by a marked increase of hGH concentration in blood with a peak value between 60 and 90 min after the administration of the drug. The hGH increase caused by clonidine was comparable to the rise during insulin-induced hypoglycemia. In 5 patients both stimuli failed to increase hGH release. The test procedure is simple. It shows only minimum side effects and can therefore be especially recommended in outpatients.
D000293:Adolescent; D001827:Body Height; D002648:Child; D002675:Child, Preschool; D003000:Clonidine / Q000627:therapeutic use*; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007003:Hypoglycemia / Q000097:blood
D013006:Growth Hormone; D003000:Clonidine