Newer aspects of the pharmacokinetics of organic nitrates.
Plasma drug and metabolite concentrations were measured after single oral doses of 40 mg sustained-release 14C-isosorbide dinitrate to humans. The bioavailability of isosorbide dinitrate from this sustained-release formulation was about 90% of that from a standard formulation. The pharmacokinetics of isosorbide-5-mononitrate were studied in humans after intravenous infusion (8 mg/h) and oral doses of 20 mg. The systemic availability of the drug after oral doses was 93%, its systemic clearance was 127 ml/min, its volume of distribution was 48.5 liters and its half-life was 4.4 h.
D001682:Biological Availability; D006801:Humans; D007548:Isosorbide Dinitrate / Q000031:analogs & derivatives / Q000378:metabolism*; D007700:Kinetics
D007548:Isosorbide Dinitrate; C030397:isosorbide-5-mononitrate