Osteomalacia associated with prostatic cancer and osteoblastic metastases.
A patient with carcinoma of the prostate, extensive bony metastases, and osteomalacia is reported. The diagnosis of osteomalacia was suspected because of generalized weakness and bone pains, hypocalcemia, hypophosphatemia, and raised alkaline phosphatase. It was documented by low 1,25-dihydroxyvitamin D level. Furthermore, it was confirmed by improvement in patient's symptomatology and normalization of serum calcium and phosphorus after treatment with 1,25-dihydroxyvitamin D3 (Rocaltrol).
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D001859:Bone Neoplasms / Q000150:complications / Q000556:secondary*; D002117:Calcitriol / Q000097:blood / Q000627:therapeutic use; D002118:Calcium / Q000097:blood; D006801:Humans; D008297:Male; D010018:Osteomalacia / Q000150:complications / Q000175:diagnosis*; D010758:Phosphorus / Q000097:blood; D011471:Prostatic Neoplasms / Q000150:complications*
D010758:Phosphorus; D000469:Alkaline Phosphatase; D002117:Calcitriol; D002118:Calcium