title: Some further data on the effects of two organophosphate pesticides on the oxidative metabolism in the liver.
abstract: Sumithion is the most active cholinesterase inhibitor. The cholinesterase inhibiting action of the organophosphates (OPs) is better compensated by vitamin E in normal animals, but by vitamin A in vitamin A-deficient animals. The lipid peroxidation (LP) is enhanced by the antioxidant vitamins in the liver of normal rats; although they decrease it in the liver of vitamin A-deficient animals, in no case do they prevent the LP-enhancing effect of the OPs examined. The OPs examined inhibit protein synthesis in the liver of vitamin A-deficient animals.
mesh_terms: D000818:Animals; D002374:Catalase / Q000378:metabolism; D002802:Cholinesterases / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D005278:Fenitrothion / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000378:metabolism; D014236:Trichlorfon / Q000494:pharmacology*; D014810:Vitamin E / Q000494:pharmacology
chemical_list: D008054:Lipid Peroxides; D014810:Vitamin E; D003577:Cytochrome P-450 Enzyme System; D014236:Trichlorfon; D002374:Catalase; D013482:Superoxide Dismutase; D002802:Cholinesterases; D005278:Fenitrothion