Combined effects of cholestyramine and probucol on regression of atherosclerosis in rhesus monkey aortas.
Adult male rhesus monkeys were fed a high fat, high cholesterol diet for 13 months. During the subsequent 12 months this diet was continued, but the animals were also treated with cholestyramine and/or probucol. The combined drug treatment caused lowering of blood cholesterol without a change in HDL-cholesterol. Regression of plaques was more marked than in animals treated with either drug alone. Animals remained in good health during the treatment period.
D000818:Animals; D001011:Aorta / Q000473:pathology; D001018:Aortic Diseases / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D001161:Arteriosclerosis / Q000097:blood / Q000188:drug therapy* / Q000473:pathology; D002792:Cholestyramine Resin / Q000627:therapeutic use*; D004036:Diet, Atherogenic; D004359:Drug Therapy, Combination; D008055:Lipids / Q000097:blood; D008253:Macaca mulatta; D008297:Male; D010636:Phenols / Q000627:therapeutic use*; D011341:Probucol / Q000627:therapeutic use*
D008055:Lipids; D010636:Phenols; D002792:Cholestyramine Resin; D011341:Probucol