[Effect of culture parameters on tobramycin biosynthesis].
The effect of temperature, aeration and active acidity of the medium on biosynthesis of tobramycin was studied. The optimal temperature conditions (37 degrees C) were developed. It was shown that biosynthesis of tobramycin depended on the aeration conditions, especially at the beginning of the fermentation process. The initial pH 4.9-6.35 and 6.35-7.1 were found to be optimal for the growth of the tobramycin-producing organism and biosynthesis of the antibiotic, respectively.
D000332:Aerobiosis; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003470:Culture Media / Q000494:pharmacology*; D005285:Fermentation; D006863:Hydrogen-Ion Concentration; D013302:Streptomyces / Q000378:metabolism; D013696:Temperature; D013997:Time Factors; D014031:Tobramycin / Q000096:biosynthesis*
D003470:Culture Media; D014031:Tobramycin
Vliianie nekotorykh parametrov kul'tivirovaniia na biosintez tobramitsina.