title: Inheritance and alcohol as factors influencing plasma uric acid levels.
abstract: Variation in plasma uric acid levels in 206 pairs of male and female twins, aged from 18 to 34 years, was consistent with a simple model including only individual environmental and additive genetic effects and a heritability of h2 = 0.73. Individual environmental variation was estimated to be approximately the same as variation of individuals measured on two occasions. Correlations of DZ pairs were also consistent with sex-linked genetic effects. In men there was a significant genetic correlation with weekly alcohol consumption and as much as 18% of the variation in uric acid levels could be accounted for by genetic variation in alcohol consumption.
mesh_terms: D000293:Adolescent; D000328:Adult; D000428:Alcohol Drinking; D004777:Environment; D005260:Female; D008040:Genetic Linkage; D014644:Genetic Variation; D006801:Humans; D008297:Male; D008957:Models, Genetic; D011247:Pregnancy; D014429:Twins, Dizygotic; D014430:Twins, Monozygotic; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid