Heart rate and breathing pattern: interactions and sex differences.
Ten subjects (five males, five females) were studied in resting conditions. Ventilation (VT, f, TI, TE), heart rate (HR) and RR interval were recorded or measured. Each subject voluntarily breathed with spontaneous frequency at different ratios of his spontaneous tidal volume (VrT). The results show that sinus arrhythmia increases with lung volume but without effect on mean heart rate. When VT is increased by two times its spontaneous value, the ventilatory drive (VT/TI) is raised in both sexes; the relative duration of inspiration (TI/Ttot) is modified (+20%) in females only. Thus with the cardiac effects of increasing lung volume being similar in both sexes, we conclude that sinus arrhythmia is not generated by sensory inputs from pulmonary structures, but that its origin is at the CNS level. Moreover, there may be a sex difference in the control of voluntary ventilation, a suggestion requiring further investigation.
D000328:Adult; D001146:Arrhythmia, Sinus / Q000503:physiopathology; D002490:Central Nervous System / Q000503:physiopathology; D005260:Female; D006339:Heart Rate; D006801:Humans; D008176:Lung Volume Measurements; D008297:Male; D012119:Respiration; D012737:Sex Factors; D013990:Tidal Volume