Canine renal lymph formation during acute ECF expansion.
Renal lymph flow, composition and pressure were related to renal function and hemodynamics before and during acute extracellular fluid (ECF) expansion (Ringer's solution, 10% of body wt.) in anesthetized dogs. ECF expansion caused increases in renal lymph pressure and flow and a decrease in the plasma concentration and L/P ratio for protein without altering the transfer rate of protein from blood to lymph (lymph clearance). In contrast, the L/P ratios for creatinine and PAH were unchanged following ECF expansion while the lymph clearances of these substances increased roughly in proportion to the increase in lymph flow. These findings are consistent with two alternative hypotheses: a) renal lymph merely participates in the generalized increase in lymph formation that follows nononcotic ECF dilution, or b) some or all of the observed lymph flow increase was derived directly from an excess of tubular reabsorbate.
D000818:Animals; D001794:Blood Pressure; D004285:Dogs; D005110:Extracellular Space / Q000502:physiology*; D005374:Filtration; D007668:Kidney / Q000502:physiology*; D008196:Lymph / Q000502:physiology*; D012079:Renal Circulation