[Effect of ethanol on the concentration of enkephalins in the brain of rats with different levels of alcoholic motivation].
Radioimmunoassay was used to measure the content of leu- and met-enkephalins in white random-bred rats divided into groups according to the duration of ethanol anesthesia and the levels of 15% ethanol consumption under the conditions of free choice. The concentration of neuropeptides was determined in the cortex of the large hemispheres, striatum, thalamus, and medulla oblongata. The short-sleeping animals manifested elevated concentration of leu-enkephalin in the cortex and that of met-enkephalin in the striatum, medulla oblongata, and thalamus. Prolonged alcoholization under the conditions of free choice led, in the much-drinking animals, to decreased concentration of leu- and met-enkephalins in the striatum, thalamus and medulla oblongata and to increased concentration of leu-enkephalin in the cortex. The importance of leu- and met-enkephalins in the pathogenesis of chronic experimental alcoholism in rats with different alcoholic motivation is considered.
D000428:Alcohol Drinking; D000437:Alcoholism / Q000523:psychology*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004743:Enkephalin, Leucine / Q000378:metabolism; D004744:Enkephalin, Methionine / Q000378:metabolism; D004745:Enkephalins / Q000378:metabolism*; D000431:Ethanol / Q000008:administration & dosage*; D006801:Humans; D007274:Injections, Intraperitoneal; D008297:Male; D009042:Motivation / Q000502:physiology*; D051381:Rats; D013997:Time Factors
D004745:Enkephalins; D000431:Ethanol; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine
Vliianie étanola na kontsentratsiiu énkefalinov v golovnom mozge krys s razlichnym urovnem alkogol'noĭ motivatsii.