[Effect of emotional-pain stress on the activity of the gamma-aminobutyric acid system].
In experiments on rats the emotional-pain stress is studied for its effect on the activity of the gamma-aminobutyric acid (GABA) system in the forebrain and stem structures, on GABA catabolism and GABA metabolism-related energy metabolism indices in the hippocamp and frontal cortex neurons. It is shown that the stress effect is accompanied by the GABA level increase and GABA-transaminase inhibition with a simultaneous rise of the succinate dehydrogenase and glutamate dehydrogenase activity. The pain factor is established to be very important for changes in the activity of GABA-transaminase and succinate dehydrogenase. The found shifts in the GABA activity system are significant for neuromediatory and energy adaptation to the stress.
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D004644:Emotions; D004734:Energy Metabolism; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism; D006801:Humans; D008297:Male; D009474:Neurons / Q000378:metabolism; D010146:Pain / Q000378:metabolism; D051381:Rats; D013315:Stress, Psychological / Q000378:metabolism*; D013385:Succinate Dehydrogenase / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D013385:Succinate Dehydrogenase; D005969:Glutamate Dehydrogenase; D000612:4-Aminobutyrate Transaminase
Vliianie émotsional'no-bolevogo stressa na aktivnost' sistemy gamma-aminomaslianoĭ kisloty.