Novel antitumor agents CI-920, PD 113,270 and PD 113,271. II. Isolation and characterization.
A complex of structurally related compounds that exhibit in vivo antileukemic activity was isolated from fermentation broths of a new streptomycete. The components of this complex are water soluble phosphate esters containing a conjugated triene system. The isolation and characterization of three of these components are described.
D000475:Alkenes / Q000302:isolation & purification; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D011090:Polyenes; D011753:Pyrones; D013053:Spectrophotometry; D013302:Streptomyces / Q000254:growth & development; D013329:Structure-Activity Relationship
D000475:Alkenes; D000903:Antibiotics, Antineoplastic; D011090:Polyenes; D011753:Pyrones; C040314:PD 113270; C040315:PD 113271; C040313:fostriecin