Modulation of antibody responses to Vibrio cholerae in mice by adoptive transfer of Peyer's patch lymphocytes from orally immunised donors.
Peyer's patch lymphocytes from mice orally primed with V. cholerae injected into recipient mice together with V. cholerae led to a considerable suppression of IgM antibody-forming cells in the spleen by comparison with control mice receiving the same schedule but with Peyer's patch lymphocytes from unprimed mice. The effect on the splenic IgA responses of recipients was variable. Incomplete separation of the Peyer's patch cells showed that both T and B cell enriched fractions were active in this suppressive effect.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000942:Antigens, Bacterial / Q000276:immunology; D022121:Cholera Vaccines / Q000276:immunology; D005260:Female; D007070:Immunoglobulin A / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D008214:Lymphocytes / Q000276:immunology*; D008221:Lymphoid Tissue / Q000276:immunology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010581:Peyer's Patches / Q000276:immunology*; D013154:Spleen / Q000276:immunology*; D014611:Vaccination / Q000379:methods; D014734:Vibrio cholerae / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D022121:Cholera Vaccines; D007070:Immunoglobulin A; D007075:Immunoglobulin M