Influence of neonatal endotoxin treatment and hormonal imprinting on thyrotropin-induced thyroxin (T4) production of adult rats.
A single subtoxic dose of endotoxin given to newborn rats by the intraperitoneal route decreased the T4 level in adulthood. TSH administration 24 hours after the endotoxin treatment failed to abolish this effect but, in this case, the response to TSH provocation in adulthood exceeded even the control value.
D000818:Animals; D000831:Animals, Newborn; D004731:Endotoxins / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006728:Hormones / Q000502:physiology*; D007274:Injections, Intraperitoneal; D008297:Male; D051381:Rats / Q000502:physiology*; D011919:Rats, Inbred Strains; D013972:Thyrotropin / Q000494:pharmacology*; D013974:Thyroxine / Q000096:biosynthesis*
D004731:Endotoxins; D006728:Hormones; D013972:Thyrotropin; D013974:Thyroxine