Introduction of carbon substituents at C-2 position of purine nucleosides.
A series of new purine nucleosides which have carbon substituents at their C-2 position were synthesized by non-aqueous diazotization/deamination of 2-amino-6-chloro-9-(2,3,5-tri-O-acetyl-beta-D-ribofuranosyl)purine (1) with isoamyl nitrite in aromatic solvents and by palladium-catalyzed alkynylation of 2-iodo-adenosine (4) with terminal alkynes.
D000478:Alkylation; D001554:Benzene; D055598:Chemical Phenomena; D002621:Chemistry; D011684:Purine Nucleosides / Q000138:chemical synthesis*; D012263:Ribonucleosides / Q000138:chemical synthesis*
D011684:Purine Nucleosides; D012263:Ribonucleosides; D001554:Benzene