Muscle substrate levels, muscle enzyme activities and muscle morphology in the vastus lateralis and deltoideus muscles in normal children and in children with coarctation of the aorta.
Muscle biopsies from the deltoideus dx and vastus lat. dx muscles were taken in 17 children with coarctation of the aorta, aged 5.0 to 13.8 years, prior to surgery. Higher concentrations of glycogen, ATP and CP were found in the vastus lat. muscle compared to the deltoideus muscle. The same differences between these two muscles were also found in healthy controls. No differences were found between the patients with coarctation of the aorta and the control group. Nor were any differences found for the other variables studied; glucose, glucose-6-phosphate, lactate, muscle enzyme activities (SDH, LDH and phosphorylase), muscle fibre composition or fibre sizes. It seems reasonable to assume that the differences in muscle substrate levels found between the vasus lat. and the deltoideus muscles in the two groups were due to a higher degree of activity during daily life for the legs as compared to the arms. Patients with coarctation of the aorta do not seem to be influenced by the altered haemodynamic situation with regard to the studied variables.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000293:Adolescent; D001017:Aortic Coarctation / Q000201:enzymology / Q000378:metabolism / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000378:metabolism; D005260:Female; D006003:Glycogen / Q000378:metabolism; D006801:Humans; D008297:Male; D009132:Muscles / Q000201:enzymology / Q000378:metabolism / Q000473:pathology
D000255:Adenosine Triphosphate; D006003:Glycogen; D003402:Creatine Kinase