title: Plasma levels of mepindolol in healthy volunteers after oral doses of mepindolol sulphate.
abstract: Three groups of healthy volunteers were given oral doses of 5, 10 and 20 mg, respectively, of the beta-receptor blocking drug mepindolol sulphate (Corindolan). Plasma levels of the active compound mepindolol were measured by means of a sensitive and specific HPLC method. Mepindolol was rapidly absorbed reaching maximum concentrations of 21 +/- 7 ng/ml (5 mg), 47 +/- 23 ng/ml (10 mg) and 54 +/- 29 ng/ml (20 mg) 1--3 h after administration. The AUC ratio of the three doses studied was 1 : 1.9 : 3.0 suggesting incomplete absorption in the 20 mg group. The biological half-life of the drug was calculated to be 3--4 h, independently of the dose administered.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010869:Pindolol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood
chemical_list: C015340:mepindolol; D010869:Pindolol