Studies on the role of catecholamines in the action of fibrinopeptides A and B in the circulatory system of rats.
Effects of fibrinopeptides A and B (FAB) in the rat circulation were examined after stimulation or inhibition of catecholamine system. FAB did not change the effects of noradrenaline and isoprenaline and increased the hypertensive action of dopamine. The effects of FAB on heart rate and blood pressure were absent in rats pretreated with propranolol and haloperidol respectively. Reserpine, alpha-methyl-p tyrosine and disulfiram diminished or abolished the effects of FAB. Apparently FAB can modify the function of adrenergic system in circulation either directly or indirectly.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002395:Catecholamines / Q000502:physiology*; D005340:Fibrinogen / Q000494:pharmacology*; D005344:Fibrinopeptide A / Q000494:pharmacology*; D005345:Fibrinopeptide B / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011941:Receptors, Adrenergic / Q000187:drug effects
D002395:Catecholamines; D011941:Receptors, Adrenergic; D005344:Fibrinopeptide A; D005345:Fibrinopeptide B; D005340:Fibrinogen