The carcinogenic effect of nitrosopiperidine administered in the drinking water of Syrian golden hamsters.
Syrian golden hamsters (Mesocricetus auratus W.) were used to test the long-term carcinogenic effect of nitrosopiperidine (NP). Groups of 30 females and 30 males were given 0.05%, 0.025% and 0.006% NP in their drinking water for life. The animals developed neoplasms in the larynx, pharynx, trachea and forestomach (papillary polyps, papillomas and epidermoid carcinomas) and in the liver (hepatocellular adenomas, carcinomas). In addition, cholangiocellular and endothelial liver tumours and colon adenocarcinomas were observed. The overall tumour frequency was dose-dependent and higher in males than in females.
D000818:Animals; D002273:Carcinogens; D006224:Cricetinae; D004032:Diet; D004067:Digestive System Neoplasms / Q000139:chemically induced*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D008647:Mesocricetus; D009602:Nitrosamines / Q000633:toxicity*; D011336:Probability; D012142:Respiratory Tract Neoplasms / Q000139:chemically induced*; D012737:Sex Factors; D013997:Time Factors
D002273:Carcinogens; D009602:Nitrosamines; C002743:N-nitrosopiperidine