Cerebral cortical perfusion during and following resuscitation from cardiac arrest in dogs.
Perfusion of the cerebral cortex during closed chest CPR in dogs, generating systolic pressures of 60 to 70 mmHg, is only 10% of pre-arrest blood flow. In contrast, internal cardiac massage produces normal cortical perfusion rates. Following a 20-min perfusion arrest, during pressure controlled reperfusion, cortical flow rates decay to less than 20% normal after 90 min of reperfusion. This appears to be due to increasing cerebral vascular resistance, and is not due to rising intracranial pressure. The post-arrest cortical hypoperfusion syndrome is prolonged with cortical flow remaining below 20% normal up to 18 hr post arrest. The use of a variety of calcium antagonists, including flunarizine, lidoflazine, verapamil, and Mg2+, immediately post-resuscitation maintains cerebral vascular resistance and cortical perfusion at normal levels. A prospective blind trial of the calcium antagonist lidoflazine following a 15-min cardiac arrest in dogs and resuscitation by internal massage, demonstrates amelioration of neurologic deficit in the early postresuscitation period.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000098:blood supply; D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D002540:Cerebral Cortex / Q000098:blood supply* / Q000503:physiopathology; D002560:Cerebrovascular Circulation / Q000187:drug effects; D002936:Cinnarizine / Q000031:analogs & derivatives / Q000494:pharmacology; D004285:Dogs; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005444:Flunarizine; D006323:Heart Arrest / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D006336:Heart Massage; D002534:Hypoxia, Brain / Q000378:metabolism; D007511:Ischemia / Q000378:metabolism; D008013:Lidoflazine / Q000494:pharmacology; D009422:Nervous System Diseases / Q000188:drug therapy; D012151:Resuscitation
D005230:Fatty Acids, Nonesterified; D002936:Cinnarizine; D000255:Adenosine Triphosphate; D008013:Lidoflazine; D005444:Flunarizine; D002118:Calcium