[Phagocyte functional activity and bactericidal systems after exposure to rifampicin, lincomycin and methicillin].
To show possible mechanisms of the inhibitory effect of rifampicin, lincomycin and methicillin on the functional activity of the phagocytes, their effect on the intracellular bactericidal systems and the state of the regulatory function of the macrophages in the immunogenesis were studied. Correlation between the decrease in the values of the phagocytosis completeness and the changes in the activity of the myeloperoxidase bactericidal system and the alkaline phosphatase in the neutrophilic granulocytes was shown. The decrease in the number of the antibody producers at the maximum level of the immune response to administration of sheep red cells as the test antigen due to rifampicin or lincomycin was not accompanied by impairment of the immune regulatory function of the macrophages.
D000818:Animals; D000921:Antibody-Producing Cells / Q000187:drug effects; D001202:Ascitic Fluid / Q000166:cytology; D007113:Immunity, Innate / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects; D008034:Lincomycin / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D008712:Methicillin / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D009504:Neutrophils / Q000187:drug effects; D010586:Phagocytes / Q000187:drug effects* / Q000276:immunology; D011817:Rabbits; D012293:Rifampin / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology
D008034:Lincomycin; D008712:Methicillin; D012293:Rifampin
Funktsional'naia aktivnost' i bakteritsidnye sistemy fagotsitov posle vozdeĭstviia rifampitsinom, linkomitsinom i metitsillinom.