Influence of impairment of the immune system on hepatic biotransformation reactions, their postnatal development and inducibility.
Neither destruction of thymus by N-methylnitrosourea or by X-rays nor thymectomy or splenectomy in rats of different ages affected hexobarbital sleeping time, ethylmorphine N-demethylation or ethoxycoumarin O-deethylation significantly and systematically. Thymectomy or thymus destruction by x-rays of newborn rats did not significantly influence postnatal development or inducibility by phenobarbital of the monooxygenase reactions.
D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D001711:Biotransformation; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004790:Enzyme Induction / Q000187:drug effects; D006591:Hexobarbital / Q000494:pharmacology; D008099:Liver / Q000201:enzymology*; D008297:Male; D008770:Methylnitrosourea / Q000633:toxicity; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects; D013156:Splenectomy; D013934:Thymectomy; D013950:Thymus Gland / Q000187:drug effects* / Q000528:radiation effects
D008770:Methylnitrosourea; D003577:Cytochrome P-450 Enzyme System; D006591:Hexobarbital; D010634:Phenobarbital