High-resolution autoradiography in mouse brain 24 h after radiolabelled CDP-choline administration.
A group of mice was given 10 microCi/animal of cytidine diphosphate choline (CDP-choline, citicoline, Somazina) (methyl 14C). Animals were sacrificed 24 h after administration and their brains isolated for electron microscopy and autoradiography. The main purpose of the present study was to examine the intracellular distribution of the drug and its possible specificity site in specific organelles and cellular structures. While a large quantity of radioactivity appeared in cellular membranes, no selectivity was in its distribution thus being detected in several cellular organelles and free hyaloplasm.
D000818:Animals; D001345:Autoradiography; D001921:Brain / Q000166:cytology / Q000378:metabolism*; D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000378:metabolism*; D051379:Mice; D013347:Subcellular Fractions / Q000378:metabolism
D003566:Cytidine Diphosphate Choline; D002794:Choline