Sister chromatid exchange levels and cell cycle time in human bone marrow cells and lymphocytes.
The frequency of sister chromatid exchange (SCE) and the cell-cycle-specific pattern of mitoses were analyzed at the same time in normal bone marrow cells and lymphocytes of six healthy donors. The SCE frequency was found to be significantly higher in lymphocytes. The cell-cycle-specific pattern revealed significantly shorter cell cycle times for normal bone marrow cells as compared with those of phytohemagglutinin (PHA) stimulated lymphocytes. Chromosomes of bone marrow metaphases displayed a more contracted morphology.
D000293:Adolescent; D000328:Adult; D001853:Bone Marrow / Q000502:physiology*; D002453:Cell Cycle; D002478:Cells, Cultured; D003434:Crossing Over, Genetic; D005260:Female; D006801:Humans; D007700:Kinetics; D008214:Lymphocytes / Q000502:physiology*; D008297:Male; D012854:Sister Chromatid Exchange