Linkage and polymorphism of a gene controlling lactate dehydrogenase in the rat.
The amount of lactate dehydrogenase subunit A in rat serum is under the control of the lactate dehydrogenase regulatory gene Ldr-1, and it is determined by two alleles, Ldr-1a (high) and Ldr-1b (low). Sex and LDH-A level segregate independently, so the Ldr-1 gene is autosomal. The genes for albino, red eye, hemoglobin, and Ldr-1 are linked (linkage group I), and their order is Ldr-1-Hbb-r-c. Our data put Ldr-1 45 cM from Hbb, and Hbb is 7 cM from c. Data in the literature separate r and c by 0.3 cM.
D000483:Alleles; D000818:Animals; D003433:Crosses, Genetic; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D005838:Genotype; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000235:genetics*; D046911:Macromolecular Substances; D008297:Male; D010641:Phenotype; D011110:Polymorphism, Genetic; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013045:Species Specificity
D007527:Isoenzymes; D046911:Macromolecular Substances; D007770:L-Lactate Dehydrogenase