title: Statistical fluctuation versus specific mechanism and the origin of the left-handed asymmetry of proteins.
abstract: We point out an intrinsic weakness in the reasoning that adduces a statistical fluctuation as the origin of a left-handed, prebiotic stereoisomeric asymmetry which might have been the initial asymmetry that led to the left-handed asymmetry of proteins observed now on Earth. The argument in favor of a statistical fluctuation as the source of the asymmetry depends implicitly on the assumption of a very small number of terrestrial sites at which polymerization leading to protein formation took place. On the other hand, the probability that a left-handed prebiotic asymmetry produced by a specific mechanism was efficacious would have increased linearly with the number of terrestrial sites. Thus, on the basis of the greater likelihood of a large number of possible polymerization sites in the prebiotic era, a random fluctuation is deemed to be a much less probable source of a stereoisomeric asymmetry than a specific mechanism, particularly the mechanism that follows from the parity violating weak interaction.
mesh_terms: D011506:Proteins; D013237:Stereoisomerism
chemical_list: D011506:Proteins