The role of dopaminergic nigro-striatal system in the aetiology of the lateral hypothalamic syndrome in cats: is there any deficit in thermoregulation?
Far-lateral hypothalamus (FLH) and substantia nigra (SN) were destroyed by radio-frequency current (RF lesion) or neurotoxically (6-hydroxydopamine injection) in 4 groups of cats. Hypothermia was observed only after 6-hydroxydopamine injections and RF lesions to FLH. Both methods of SN damage did not affect the body temperature of animals. These results suggest that hypothermia observed in LH syndrome in cats is not directly related to the function of the dopaminergic nigro-striatal system.
D000818:Animals; D001833:Body Temperature Regulation; D002415:Cats; D003342:Corpus Striatum / Q000503:physiopathology*; D007026:Hypothalamic Area, Lateral; D007027:Hypothalamic Diseases / Q000209:etiology*; D007035:Hypothermia / Q000209:etiology; D011954:Receptors, Dopamine / Q000502:physiology*; D013378:Substantia Nigra / Q000503:physiopathology*
D011954:Receptors, Dopamine