Examination of rat placental lactogen and prolactin at 6-hr intervals during midpregnancy.
The Nb2 node lymphoma cell bioassay was verified in our laboratory as a sensitive, reproducible, and accurate bioassay for measurement of serum rat placental lactogen (rPL). Blood samples taken every 6 hr during pregnancy showed a significant peak of rPL secretion in the late afternoon on Day 11. The inverse relationship between rPL and nocturnal prolactin (PRL) surges is shown.
D000818:Animals; D001681:Biological Assay; D002452:Cell Count; D002455:Cell Division / Q000187:drug effects; D002940:Circadian Rhythm; D005260:Female; D008223:Lymphoma / Q000473:pathology; D010928:Placental Lactogen / Q000097:blood*; D011247:Pregnancy; D011270:Pregnancy, Animal; D011388:Prolactin / Q000097:blood*; D051381:Rats
D011388:Prolactin; D010928:Placental Lactogen