[Effect of opiates on Ca2+ transport in synaptosomes].
Potassium-stimulated uptake of Ca2+ by nerve-ending fractions from rat brain (synaptosomes) is inhibited by morphine and [D-Ala2, D-Leu5]enkephalin. This effect develops significantly within 1 minute. The opiates do not affect the Ca2+ efflux from the synaptosomes. Naloxone, the opiate antagonist, does not reverse the effect of morphine on synaptosomal Ca2+ uptake, and in this respect itself acts similarly to morphine).
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D003864:Depression, Chemical; D066298:In Vitro Techniques; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013574:Synaptosomes / Q000378:metabolism*
D009270:Naloxone; D009020:Morphine; D002118:Calcium
Vliianie opiatov na transport Ca2+ v sinaptosomy.