Movement of myosin-coated structures on actin cables.
Myosin-coated spheres from 0.6 to 120 microns in diameter move in vitro on a substratum of polar arrays of actin cables derived from the alga Nitella. The force for this movement is provided by skeletal muscle myosin since it is ATP-dependent, and N-ethylmaleimide (NEM) inactivation of the myosin blocks movement. These observations demonstrate that attachment of myosin in a random orientation to structures will enable those structures to move along polar arrays of actin filaments.
D000199:Actins / Q000502:physiology*; D000255:Adenosine Triphosphate / Q000494:pharmacology; D056890:Eukaryota; D009068:Movement; D009218:Myosins / Q000502:physiology*
D000199:Actins; D000255:Adenosine Triphosphate; D009218:Myosins