title: Sympathetic postganglionic unmyelinated axons in the rat peripheral nervous system.
abstract: We determined the contribution made to the unmyelinated axon population of the rat peripheral nervous system by sympathetic paravertebral ganglion cells. Sympathectomy, achieved by administration of guanethidine to neonatal rats, led to atrophy of the sympathetic paravertebral ganglion chain, a 95% decrease in peripheral nerve norepinephrine, and loss of 20 to 26% of the unmyelinated axons in a cutaneous nerve (sural), a muscular nerve (nerve to soleus), and a mixed nerve (sciatic). These data indicate that up to a quarter of the total population of peripheral nerve unmyelinated axons are sympathetic ganglia-derived.
mesh_terms: D000818:Animals; D001369:Axons / Q000033:anatomy & histology; D005260:Female; D005728:Ganglia, Sympathetic / Q000033:anatomy & histology*; D006145:Guanethidine; D008297:Male; D009132:Muscles / Q000294:innervation; D009186:Myelin Sheath / Q000033:anatomy & histology*; D010525:Peripheral Nerves / Q000033:anatomy & histology; D051381:Rats; D011919:Rats, Inbred Strains; D012584:Sciatic Nerve / Q000033:anatomy & histology*; D013127:Spinal Nerves / Q000033:anatomy & histology*; D013497:Sural Nerve / Q000033:anatomy & histology*; D013563:Sympathectomy, Chemical
chemical_list: D006145:Guanethidine