Naloxone and alcohol intoxication in the dog.
1 The effects of naloxone upon ethanol-induced coma have been investigated in dogs. In a double blind study, 15 mongrel dogs received ethanol i.v. (4 g/kg) followed by a single dose of naloxone (12 micrograms/kg). 2 Naloxone failed to affect either the duration of respiratory arrest or the time to recovery of motor coordination. In similar animals treated with the narcotic analgesic, fentanyl, naloxone induced a dramatic and complete reversal of the narcotic effects within 30 seconds. 3 It is concluded that, if naloxone has any effect in alcoholic coma, it is not comparable with its dramatic action in narcotic coma.
D000435:Alcoholic Intoxication / Q000188:drug therapy*; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004285:Dogs; D000431:Ethanol / Q000097:blood; D005283:Fentanyl / Q000627:therapeutic use; D006801:Humans; D009270:Naloxone / Q000627:therapeutic use*; D004856:Postural Balance / Q000187:drug effects; D012119:Respiration / Q000187:drug effects
D001786:Blood Glucose; D009270:Naloxone; D000431:Ethanol; D005283:Fentanyl