Plasma HDL in non-insulin-dependent diabetes and the effect of various types of treatment.
High density lipoprotein was studied in a group of non-insulin-dependent diabetics in relation to treatment with the hypoglycaemic sulphonylureas and biguanides. The effect of these drugs on hyperlipidaemia was also studied. HDL cholesterol (HDL-C) was reduced in all the diabetics, with no differences between the three groups studied:--diet-treated, SU-treated and biguanide-treated. The SU-treated group had lower cholesterol and triglycerides than the non-treated group. Biguanide treatment only affected the triglycerides level, but the difference from the non-treated group was not significant.
D000328:Adult; D000368:Aged; D001645:Biguanides / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000178:diet therapy / Q000188:drug therapy; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013453:Sulfonylurea Compounds / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
D001645:Biguanides; D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D013453:Sulfonylurea Compounds; D014280:Triglycerides; D002784:Cholesterol