title: Chemotherapeutic treatment of naturally acquired generalized demodicosis.
abstract: Fifty-two dogs naturally parasitized with Demodex canis and having the generalized form of the disease were utilized to evaluate the efficacy and safety of single or multiple topical treatments with a liquid concentrate formulation of amitraz. Ten dogs (5 treated, 5 controls) were utilized to evaluate a single treatment. A single topical treatment with the miticide did not significantly reduce the incidence of dogs with mites, however, significant clinical improvement resulted. Side-effects were not observed after treatment. Forty-two dogs (26 treated, 16 controls) were utilized to evaluate multiple topical treatments with the liquid concentrate. A series of 3-6 treatments was applied topically at 14-day intervals. The dogs treated with the miticide received an average of 4.5 topical treatments. All (100%) of the dogs responded clinically, and the mean rate of improvement at four weeks post-treatment was 99.1%. Most dogs (96.2%) were cleared of mites after 3-6 treatments, and Mitaban did not cause any dermatologic, ocular, or other clinical side-effects. Multiple treatments with the liquid concentrate were highly efficacious and safe for treatment of generalized demodicosis. Control dogs did not improve clinically and retained mite populations.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D007306:Insecticides / Q000008:administration & dosage / Q000627:therapeutic use*; D008924:Mite Infestations / Q000188:drug therapy / Q000662:veterinary*; D014052:Toluidines / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D007306:Insecticides; D014052:Toluidines; C014983:amitraz