Selection for resistance to phallolysin, a cytolytic toxin from the death-cap mushroom (Amanita phalloides).
Phallolysin-resistant variants are readily selected from unmutagenized populations of mouse fibroblasts. They exhibit partial cross-resistance to wheat germ agglutinin, a lectin with a saccharide specificity similar to phallolysin. These results are consistent with phallolysin acting by binding to cell surface glycoprotein receptors rather than by interacting directly with lipid components of the membrane.
D000363:Agaricales / Q000032:analysis*; D000545:Amanita / Q000032:analysis*; D000546:Amanitins / Q000633:toxicity*; D000818:Animals; D002478:Cells, Cultured; D003603:Cytotoxins / Q000633:toxicity*; D004351:Drug Resistance; D037102:Lectins / Q000494:pharmacology; D051379:Mice
D000546:Amanitins; D003603:Cytotoxins; D037102:Lectins; C008824:phallolysine