Synthesis of C-2 and C-4 deuterium-labeled estradiol-17 beta.
Estradiol-17 beta labeled with deuterium in the positions 2 or 4 can be prepared from 2-chloromercurio-1,3,5(10)-estratriene-3,17 beta-diol 3-methyl ether 17-acetate or 4-chloromercurio-1,3,5(10)-estratriene-3,17 beta-diol, respectively, in refluxing CH3COO(2)H/(2)H2O. The same reaction performed on 4-acetoxymercurio-1,3,5(10)-estratriene-3,17 beta-diol afforded 2,4-dideuterio-estradiol-17 beta in good yields.
D003903:Deuterium; D004958:Estradiol / Q000138:chemical synthesis*; D007553:Isotope Labeling
D004958:Estradiol; D003903:Deuterium