The possible mechanism of protection induced by dexamethasone against sudden death due to coronary ligation in conscious rats.
Rat isolated peritoneal cells (10(7) cells ml-1) incubated in the presence of dexamethasone (3 X 10(-9) M, for 90 min) were shown to release some factor(s), having a mol. wt. of 15 k, as determined by size exclusion chromatography, which inhibited phospholipase A2 activity and offered significant protection against sudden death due to post-infarction arrhythmias in conscious rats pretreated with actinomycin D (0.5 mg kg-1 i.v. 4 h before coronary ligation). This observation suggests that the cardioprotective effect of glucocorticoids in acute myocardial infarction may result from the de novo synthesis of macrocortin, an antiphospholipase protein.
D000818:Animals; D003327:Coronary Disease / Q000503:physiopathology*; D003645:Death, Sudden; D003907:Dexamethasone / Q000494:pharmacology*; D006023:Glycoproteins; D047908:Intracellular Signaling Peptides and Proteins; D008297:Male; D010455:Peptides / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains
D006023:Glycoproteins; D047908:Intracellular Signaling Peptides and Proteins; D010455:Peptides; C027564:macrocortin protein, rat; D003907:Dexamethasone