Retrograde transport in corticospinal neurons after spinal cord transection.
Complete spinal cord transection at T-6/T-7 in rats caused a decrease in the number of surviving corticospinal neurons. Cell death began 5 and 10 weeks after cord injury. The number of surviving cells decreased progressively for at least 25 weeks after injury. Surviving cells were identified by their ability to transport horseradish peroxidase (HRP) retrograde from a T-1/T-2 insertion site to cortical cell somas. Therapy aimed at promoting corticospinal tract regeneration must be started early after spinal cord injury.
D000818:Animals; D002470:Cell Survival; D002540:Cerebral Cortex / Q000473:pathology*; D005260:Female; D006735:Horseradish Peroxidase; D009410:Nerve Degeneration; D009416:Nerve Regeneration; D009474:Neurons / Q000473:pathology; D011712:Pyramidal Tracts / Q000473:pathology*; D051381:Rats; D013119:Spinal Cord Injuries / Q000473:pathology* / Q000534:rehabilitation; D013997:Time Factors
D006735:Horseradish Peroxidase