title: A computer program for the analysis of double isotope renal clearance assays.
abstract: A computer program is given for the analysis of double isotope renal clearance assays. A program for use with computerized gamma counters or desk-top computers is described for the calculation of effective renal plasma flow and glomerular filtration rate from data obtained with the single injection technique. Using standard statistical algorithms the program rapidly computes the fast and slow exponential clearance components, together with their standard errors, from the observed plasma disappearance curves of both isotopes, and thus obviates the need for their manual graphical resolution. The program has been in routine use for 3 years and successfully processed 109 renal clearance assays from a wide variety of patients whose kidney function ranged from normal to severely impaired.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002860:Chromium Radioisotopes; D003201:Computers; D005919:Glomerular Filtration Rate; D006801:Humans; D007223:Infant; D007457:Iodine Radioisotopes; D007674:Kidney Diseases / Q000175:diagnosis; D007677:Kidney Function Tests / Q000379:methods*; D012079:Renal Circulation; D012984:Software
chemical_list: D002860:Chromium Radioisotopes; D007457:Iodine Radioisotopes