Synthesis of (N-acetyl-1-O-acylmuramoyl)-L-alanyl-D-isoglutamines, and their immunoadjuvant activities.
1-O-Acyl derivatives of N-acetylmuramoyl-L-alanyl-D-isoglutamine (MDP) have been synthesized from 2-acetamido-1-O-benzoyl-4,6-O-isopropylidene-3-O-[D-1-(methoxycarbonyl) ethyl]-alpha-D-glucopyranose. Their immunoadjuvant activities were examined in guinea-pigs.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D000276:Adjuvants, Immunologic; D000818:Animals; D001681:Biological Assay; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed; D007202:Indicators and Reagents; D013329:Structure-Activity Relationship
D000276:Adjuvants, Immunologic; D007202:Indicators and Reagents; D000119:Acetylmuramyl-Alanyl-Isoglutamine