PTH and vitamin D responses during treatment of hypomagnesaemic hypoparathyroidism.
The response of calcium regulating hormones in a patient with hypomagnesaemic hypoparathyroidism was assessed during magnesium infusion. Magnesium repletion was accompanied by prompt restoration of PTH secretion which subsequently stimulated 1,25-diOHD3 production, thus correcting hypocalcaemia. Further, failure of the patient to respond to previous 1 alpha-OHD3 therapy suggests that severe magnesium depletion may also result in a state of acquired resistance to the active metabolites of vitamin D.
D002112:Calcifediol / Q000097:blood / Q000378:metabolism*; D002116:Calcitonin / Q000097:blood / Q000378:metabolism*; D002117:Calcitriol / Q000097:blood / Q000378:metabolism*; D002118:Calcium / Q000097:blood / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use; D007011:Hypoparathyroidism / Q000097:blood / Q000188:drug therapy*; D008274:Magnesium / Q000494:pharmacology; D008275:Magnesium Deficiency; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood / Q000378:metabolism*
D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone; D002116:Calcitonin; D002117:Calcitriol; D008274:Magnesium; D002112:Calcifediol; D002118:Calcium; C008088:alfacalcidol