A longitudinal study of speech fluency in aphasia: CT correlates of recovery and persistent nonfluency.
The anatomic correlates of speech fluency were studied in 54 right-handed patients with aphasia due to stroke. Speech fluency was assessed at 1 month postonset and then monthly for 5 months. CTs obtained at 5 months postonset were used for lesion localization and volume determination. Persistent nonfluency was associated with lesions in the rolandic cortical region and underlying white matter. Recovery from nonfluency occurred in 6 of 27 patients. Lesions in these six patients were less extensive than lesions in patients with persistent nonfluency. Patients who were fluent by 1 month lacked extensive rolandic lesions.
D000328:Adult; D000368:Aged; D001037:Aphasia / Q000000981:diagnostic imaging* / Q000209:etiology; D001921:Brain / Q000000981:diagnostic imaging*; D002561:Cerebrovascular Disorders / Q000150:complications / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D013064:Speech Disorders / Q000000981:diagnostic imaging* / Q000209:etiology; D014057:Tomography, X-Ray Computed