[Mechanism of the microcirculatory effects of ethyl-3,5,6-tri-O-benzyl-D-glucofuranoside].
According to the rheo- and photoplethysmography data, ethyl-3,5,6-tri-O-benzyl-D-glucofuranoside (glivenol, tribenol; 25,250 and 4000 mg/kg i.p.) markedly increases the blood content in hind limbs of rabbits, displaying a tendency towards a decrease in systemic arterial pressure and negligibly raises the body temperature when given in maximal doses, without affecting cardiac activity and respiration. The mechanism of the drug hemodynamic effect revealed is determined by activation of the blood flow in precapillary vessels. This plays an essential role in pathogenetic therapy of microcirculatory and trophic disorders in chronic venous failure.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002317:Cardiovascular Agents / Q000494:pharmacology*; D002463:Cell Membrane Permeability / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D006027:Glycosides / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D006614:Hindlimb / Q000098:blood supply*; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D011817:Rabbits; D013997:Time Factors
D002317:Cardiovascular Agents; D006027:Glycosides; C100302:tribenoside
O mekhanizme mikrotsirkuliatornykh éffektov étil-3,5,6-tri-O-benzil-D-gliukofuranozida.