title: Metabolism of tetraorganolead compounds by rat-liver microsomal mono-oxygenase. I. Analytical methods for quantitative determination of dealkylation products.
abstract: Different methods have been examined for the separation and determination of the triethyl lead ion in the presence of tetraethyl lead in biological material. Quantitative recovery of triethyl lead, and a limit of detection of less than 10(-8)M, were obtained with selective chromatography on kieselguhr (Extrelut) in combination with atomic absorption spectrometry.
mesh_terms: D000818:Animals; D003640:Dealkylation; D004230:Dithizone; D007854:Lead / Q000032:analysis / Q000378:metabolism*; D008297:Male; D008722:Methods; D008862:Microsomes, Liver / Q000201:enzymology*; D009942:Organometallic Compounds / Q000032:analysis / Q000378:metabolism*; D010105:Oxygenases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013756:Tetraethyl Lead
chemical_list: D009942:Organometallic Compounds; D013756:Tetraethyl Lead; D007854:Lead; D004230:Dithizone; C010360:triethyllead; D010105:Oxygenases