Is the brain histamine involved in cataleptogenic action of analgesics and haloperidol?
L-Histidine, histamine ivc, and amodiaquine (inhibitor of histamine catabolism) enhanced catalepsy induced by morphine, codeine and fentanyl. Haloperidol catalepsy was increased only by ivc histamine. H1 (but not H2) receptor antagonists have shown anticataleptic effect in the action of analgesics and haloperidol.
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D002375:Catalepsy / Q000503:physiopathology*; D006220:Haloperidol / Q000494:pharmacology*; D006632:Histamine / Q000502:physiology*; D006639:Histidine / Q000494:pharmacology; D006801:Humans; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000700:Analgesics; D006639:Histidine; D006632:Histamine; D006220:Haloperidol