Psychoactive drugs and stimulus analysis: III. Adjustment of behavioural measures for drug-induced memory effects and state dependence: the case of chlorpromazine.
Chlorpromazine is shown to have a suppressant effect upon stimulus analysis when given intraperitoneally as a 1 mg/kg dose to rats. The drug has no effects upon motor activity at this dose, but does impair short-term memory. These findings are based upon an examination of chlorpromazine in a newly-designed psychoactive drug classification test which allows adjustments to be made for drug-induced memory effects and for the influence of state dependence. The rationale for these adjustments to behavioural measures is presented in detail.
D000818:Animals; D001143:Arousal / Q000187:drug effects*; D002746:Chlorpromazine / Q000494:pharmacology*; D005106:Exploratory Behavior / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects*; D011619:Psychotropic Drugs / Q000145:classification; D051381:Rats
D011619:Psychotropic Drugs; D002746:Chlorpromazine