Treatment of chronic dyskinesia with CDP-choline.
Ten patients older than 60 years suffering from tardive dyskinesia consecutive to a long-term treatment with neuroleptics were included in a study with the scope to check the efficacy of cytidine diphosphate choline (CDP-choline, citicoline, Somazina) in these disorders. The drug was administered for four weeks at daily doses of 500-1200 mg. The evaluations of the symptomatology carried out with the Simpson's abbreviated scale, showed statistically significant reductions between the beginning and the end of the treatment. The tolerance of the drug was satisfactory.
D000109:Acetylcholine / Q000378:metabolism; D002794:Choline / Q000031:analogs & derivatives*; D003566:Cytidine Diphosphate Choline / Q000627:therapeutic use*; D004409:Dyskinesia, Drug-Induced / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011954:Receptors, Dopamine / Q000187:drug effects
D011954:Receptors, Dopamine; D003566:Cytidine Diphosphate Choline; D002794:Choline; D000109:Acetylcholine