Metabolism of the NH2-terminal tridecapeptide of gastrin-17 in normal subjects and duodenal ulcer patients.
The metabolism of the NH2-terminal tridecapeptide fragment of gastrin-17 (1-13)G-17) was examined in normal subjects and duodenal ulcer patients. A dose of 65 pmol synthetic human (1-13)G-17/kg/h was infused intravenously for 90 min. After cessation of infusion the disappearance curve was similar in the two groups. The mean half-life, volume of distribution, and clearance rate were, for normal and duodenal ulcer subjects, 6.3 and 6.3 min, 100 and 93 ml/kg, and 11.0 and 10.2 ml/kg/h, respectively. The gastric acidity decreased during the infusion in duodenal ulcer patients (54 +/- 11 to 40 +/- 10 meq/l (p less than 0.02] but not in normal subjects. The results suggest that the increased serum concentrations of the NH2-terminal fragment of gastrin-17 in duodenal ulcer patients are not caused by a decreased metabolism of (1-13)G-17. Moreover, the data show that (1-13)G-17 reduces gastric acid secretion.
D000328:Adult; D004381:Duodenal Ulcer / Q000378:metabolism*; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010446:Peptide Fragments / Q000378:metabolism*
D005755:Gastrins; D010446:Peptide Fragments; C013550:gastrin 17