Recovery of acetylsalicylic acid and indalpine (LM 5008) after buccal partitioning.
The recoveries were compared of acetylsalicylic acid (ASA) and indalpine (1) after buccal absorption in three trained human volunteers. Recovery of the poorly lipid soluble ASA was less than 1% at pH 5 or 8, while that of the lipid soluble I was 19% and 13% at pH 5 and 8 respectively. This difference in recovery may represent a difference in their storage within the buccal mucosa dependent on their different lipid solubilities.
D000042:Absorption; D001241:Aspirin / Q000378:metabolism*; D002610:Cheek; D002626:Chemistry, Pharmaceutical; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D009061:Mouth Mucosa / Q000378:metabolism*; D010880:Piperidines / Q000378:metabolism*
D010880:Piperidines; D001241:Aspirin; C018181:indalpine