2-Mercapto-1-methyl-5-methylmercapto-imidazole: a new metabolite of thiamazole.
2-Mercapto-1-methyl-5-methylmercapto-imidazole (13) was found in urine samples of man and rat after intake of thiamazole (1). It is assumed that the metabolite is produced via a N-oxidation intermediate enabling a nucleophilic attack at carbon-5 in the thiazole ring.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy; D008297:Male; D008713:Methimazole / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology / Q000652:urine; D008745:Methylation; D008954:Models, Biological; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains
C040917:2-mercapto-1-methyl-5-methylmercaptoimidazole; D008713:Methimazole