title: Toxicity of Senecio jacobaea and pyrrolizidine alkaloids in various laboratory animals and avian species.
abstract: The chronic toxicity of tansy ragwort (Senecio jacobaea) to several herbivorous laboratory animals and to chicks and turkey poults was examined by feeding the dried plant as a component of a mixed diet. Gerbils, hamsters and guinea pigs were resistant to chronic toxicity. Gerbils were highly resistant, consuming over 3500% of their body weight of the dried plant, whereas susceptible species succumb to a tansy ragwort intake of 5-20% of their body weight. Guinea pigs and gerbils were resistant to acute toxicity of injected monocrotaline, a pyrrolizidine alkaloid (PA). They were moderately resistant to acute toxicity of injected tansy ragwort alkaloids. Both chicks and turkey poults were susceptible to chronic toxicity of dietary tansy ragwort.
mesh_terms: D000818:Animals; D002645:Chickens; D004032:Diet; D004351:Drug Resistance; D005849:Gerbillinae; D006168:Guinea Pigs; D051379:Mice; D011763:Pyrrolizidine Alkaloids / Q000633:toxicity*; D013045:Species Specificity; D014422:Turkeys
chemical_list: D011763:Pyrrolizidine Alkaloids