title: [Specificity of the sensitivity of inbred mouse strains TPS, WR and CBA/LacY to the action of chemical mutagens].
abstract: The cytogenetic effect of thioTEPA, ethyleneimine, mitomycin C, cyclophosphamide and phtorafurum in bone marrow cells of mouse strains TPS, WR, CBA/LacY was studied. Mice of the TPS strains were most sensitive to the action of all mutagens. Mice of the WR strain were sensitive to thioTEPA and phtorafurum but relatively resistant to mutagens which require metabolic preactivation, i. e. mitomycin C and cyclophosphamide. It was suggested to carry out the study of the cytogenetic activity of chemical compounds using the panel of TPS, WR, 101/H, C57BL/6Y, CBA/LacY strains.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D004351:Drug Resistance; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D013045:Species Specificity
chemical_list: D009153:Mutagens
vernacular_title: Spetsifika chuvstvitel'nosti mysheĭ inbrednykh liniĭ TPS, WR i CBA/LacY k deĭstviiu khimicheskikh mutagenov.