Anticonvulsant action of new cyclic derivatives of phenylsuccinimides.
The toxicity of three new cyclic derivatives of phenylsuccinimide, IL-7, I-10, I-11, and their anticonvulsant activity with the use of electric and chemical induced convulsion tests were investigated in animals; ED50 and LD50 were calculated. The new compounds were found to display anticonvulsant action similar to that of Lefadol and ethosuximide and to have interesting values to therapeutic index. They seemed to be less toxic as compared to classical succinimides.
D000818:Animals; D000927:Anticonvulsants / Q000633:toxicity; D004597:Electroshock; D007928:Lethal Dose 50; D051379:Mice; D013388:Succinimides / Q000494:pharmacology* / Q000633:toxicity
D000927:Anticonvulsants; D013388:Succinimides