Synthesis and in vivo studies of the radiosensitizer 4-[82Br]bromomisonidazole.
[82Br]Misonidazole ( [82Br]MISO) was investigated as a potential agent for scintillation imaging and indexing of hypoxic areas in tumor masses. [82Br]MISO was prepared by irradiating samples of Br-MISO in a SLOWPOKE reactor for 2 h at a thermal neutron flux of 10(12) n cm-2 s-1. Radiochemical yields ranged from 11 to 16%. [82Br]MISO had a plasma clearance half-life of approximately 40 min in BALB/c mice bearing EMT-6 tumors. The major metabolic product was identified as [82Br]Desmisonidazole. [82Br]MISO showed relatively high tumor uptake and persistently high plasma levels.
D000818:Animals; D001966:Bromine; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000000981:diagnostic imaging* / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008920:Misonidazole / Q000031:analogs & derivatives / Q000378:metabolism; D009368:Neoplasm Transplantation; D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents; D011868:Radioisotopes; D011877:Radionuclide Imaging; D014018:Tissue Distribution
D009593:Nitroimidazoles; D011838:Radiation-Sensitizing Agents; D011868:Radioisotopes; C035756:4-bromomisonidazole; D008920:Misonidazole; D001966:Bromine