title: [Changes in the combined activity of the thyroid and the fascicular zone of the adrenal cortical substance in the development of subcutaneous connective tissue inflammation during prolactin administration].
abstract: As demonstrate the experiments performed in white male rats, during development of an inflammatory reaction, some essential fluctuations take place in nicotinamide dinucleotide. H2 (HAD.H2), nicotinamide dinucleotide phosphate. H2 (NADPh.H2), glucose-6-phosphate-dehydrogenase (G-6-PhDH), monoaminoxydase (MAO) activities and in content of ascorbic acid in the fascicular zone of the adrenals and the same enzymes in the thyroid follicular cells. There is a reverse connection between the adrenal fascicular zone and the thyroid gland activity. At inflammation, prolactin increases MAO and G-6-PhDH activity in thyrocytes and adrenocorticocytes of the adrenal fascicular zone, changes correlation between NAD.H2-DG and NADPh.H2-DG activities. At an acute inflammation, prolactin activates the thyroid gland function, and during the reparative period--decreases it. During the inflammation period, prolactin administration decreases contingency of the indices in the thyroid gland-adrenals systems, that is to say produces a dissociative effect; it is, perhaps, connected with certain changes in balance and a mediatory role of biogenic amines.
mesh_terms: D000302:Adrenal Cortex / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D002481:Cellulitis / Q000209:etiology* / Q000378:metabolism; D006651:Histocytochemistry; D008297:Male; D011388:Prolactin / Q000008:administration & dosage*; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors
chemical_list: D011388:Prolactin
vernacular_title: Izmenenie sochetannoĭ deiatel'nosti shchitovidnoĭ zhelezy i puchkovoĭ zony korkovogo veshchestva nadpochechnikov pri razvitii vospaleniia v podkozhnoĭ soedinitel'noĭ tkani na fone vvedeniia prolaktina.