Effect of rice diet on chloroquine bioavailability.
The effect of rice-based meals on chloroquine bioavailability was assessed in six healthy adult male volunteers. Chloroquine (600 mg base) was administered orally in two circumstances: on empty stomach and along with a rice-based breakfast. Timed blood samples were obtained to determine the plasma concentrations of the drug. The results suggest that the area under the concentration curve (AUC0-12) and peak plasma levels are significantly higher when chloroquine is administered along with food, though the rate of absorption is not different. It appears, therefore, that a rice-based meal facilitates chloroquine absorption, thereby increasing the bioavailability of the drug.
D000328:Adult; D001682:Biological Availability; D002738:Chloroquine / Q000097:blood / Q000378:metabolism*; D004032:Diet; D006801:Humans; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D012275:Oryza
D002738:Chloroquine