Potential tissue-imaging agents: 23-(trimethyl [117mSn]stannyl)-24-nor-5 alpha-cholan-3 beta-ol.
Tin-117m-labeled 23-(trimethylstannyl)-24-nor-5 alpha-cholan-3 beta-ol (2) has been prepared by reaction of trimethyl [117mSn]tin lithium with 3 beta-acetoxy-23-bromo-24-nor-5 alpha-cholane (1). Tin-117m (2) shows pronounced adrenal uptake (2.5% injected dose) in female rats 1 day after injection. Furthermore, the adrenal to liver (9.1:1) and adrenal to blood (33.7:1) ratios are high after this period. The absorbed radiation dose values from [117mSn]2 to human organs have also been estimated by using rat tissue distribution and excretion data. [117mSn]2 is the first reported tissue-specific organic radiopharmaceutical labeled with this nuclide and may have potential as an adrenal imaging agent.
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D002757:Cholanes / Q000138:chemical synthesis* / Q000378:metabolism; D005260:Female; D007202:Indicators and Reagents; D007668:Kidney / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D013058:Mass Spectrometry; D010053:Ovary / Q000378:metabolism; D011868:Radioisotopes; D011877:Radionuclide Imaging / Q000379:methods*; D051381:Rats; D013055:Spectrophotometry, Infrared; D014018:Tissue Distribution; D014220:Trialkyltin Compounds / Q000138:chemical synthesis*; D014298:Trimethyltin Compounds / Q000138:chemical synthesis* / Q000378:metabolism
D002757:Cholanes; D007202:Indicators and Reagents; D011868:Radioisotopes; D014220:Trialkyltin Compounds; D014298:Trimethyltin Compounds; C039373:23-(trimethylstannyl)-24-norcholan-3-ol