Dissociation of glucose and potassium arterial-venous differences across the forearm by acetazolamide. A possible relationship to acetazolamide's beneficial effect in hypokalemic periodic paralysis.
We studied the effect of acetazolamide on arterial-venous (A-V) glucose and potassium differences across the forearm following oral glucose loading in eight normal subjects. Administration of acetazolamide for 72 hours prior to glucose loading resulted in increased A-V glucose differences and decreased A-V potassium differences. Acetazolamide may, therefore, increase glucose uptake across muscle while decreasing potassium uptake following glucose ingestion. This glucose-potassium dissociation observed in normal subjects may relate to acetazolamide's beneficial effect in hypokalemic periodic paralysis.
D000086:Acetazolamide / Q000494:pharmacology* / Q000627:therapeutic use; D000328:Adult; D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D004040:Dietary Carbohydrates / Q000378:metabolism; D005260:Female; D005542:Forearm / Q000098:blood supply; D006801:Humans; D007008:Hypokalemia / Q000097:blood / Q000188:drug therapy / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D010245:Paralyses, Familial Periodic / Q000097:blood* / Q000188:drug therapy / Q000378:metabolism; D011188:Potassium / Q000097:blood* / Q000378:metabolism
D001786:Blood Glucose; D004040:Dietary Carbohydrates; D000086:Acetazolamide; D011188:Potassium