title: Radiographic and histologic evaluation of intramedullary implants intended for biological fixation.
abstract: Three mechanisms of direct biological attachment of implants to bone were examined using femoral intramedullary implants. The implant systems studied were; low temperature isotropic (LTI) pyrolytic carbon, carbon coated porous Co-Cr-Mo alloy and 45S5 bioglass coated Co-Cr-Mo alloy. A detailed radiographic examination revealed that all three implant systems caused significant remodeling of the femurs resulting in an hour-glass appearance. The implants were also associated with a densification of cancellous bone proximal and distal to the ends of the implant. Histologically, all three implant systems exhibited a direct bone-implant bond at the majority of the interfaces. The LTI pyrolytic carbon implants were associated with a higher incidence of fibrous tissue encasement in the proximal cancellous bone region. Active bone remodeling was observed within the pores of the porous Co-Cr-Mo alloy implants even after 8 months in situ.
mesh_terms: D000497:Alloys; D000818:Animals; D001853:Bone Marrow / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D001842:Bone and Bones / Q000033:anatomy & histology* / Q000000981:diagnostic imaging; D002244:Carbon; D002516:Ceramics; D002857:Chromium; D004285:Dogs; D005269:Femur / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D005594:Fracture Fixation, Intramedullary; D008982:Molybdenum; D019736:Prostheses and Implants; D011859:Radiography
chemical_list: D000497:Alloys; C022107:Bioglass; C009139:pyrolytic carbon; D002857:Chromium; D002244:Carbon; D008982:Molybdenum