[Effect of co-dergocrine mesylate on catecholamines and prolactin in elderly hypertensive patients].
The antihypertensive efficacy of co-dergocrine mesylate (a mixture of dihydroergocornine mesylate, dihydroergocristine mesylate, and alpha- and beta-dihydroergocryptine mesylates; Hydergin) and its effects on heart rate, plasma catecholamines, catecholamine excretion and plasma prolactin was tested in 12 elderly hypertensive patients. Co-dergocrine mesylate (6 mg or 12 mg, 1 or 2 tablets once a day) caused a significant reduction of the blood pressure during rest and under physical stress without a reactive increase of the heart rate. Plasma norepinephrine and prolactin as well as urinary excretion of norepinephrine and epinephrine were not affected by co-dergocrine mesylate. The therapeutic advantage of co-dergocrine mesylate for the treatment of hypertension in the elderly is discussed.
D000368:Aged; D000959:Antihypertensive Agents; D002395:Catecholamines / Q000097:blood*; D004088:Dihydroergotoxine / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*
D000959:Antihypertensive Agents; D002395:Catecholamines; D004088:Dihydroergotoxine; D011388:Prolactin
Wirkung von Co-Dergocrinmesylat auf Katecholamine und Prolaktin bei älteren Hypertonikern.