[Concept of therapeutic ratio by combination of radiotherapy and chemotherapy].
In combined application of radiation and drugs, the maximum therapeutic ratio should be accomplished by effective combination of the following various means. 1. Effective combination from the aspect of cell kinetics. 2. Application of hypoxic sensitizer or PLDR-inhibitor to cells of the resting phase that are resistant to radiation and chemotherapy. 3. improvement of the method of anti-cancer drug administration. 4. Reasonable planning of the intervals of radiation and chemotherapy. In solid tumors, the proportion of proliferating phase decreases with the increase in the tumor size. Anti-cancer drugs are usually effective to cells of the proliferating phase only, and cells of the resting phase are resistant to radiation. This indicates the absolute necessity of multi-modal treatment including surgical management.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002450:Cell Communication / Q000528:radiation effects; D002453:Cell Cycle / Q000528:radiation effects; D003131:Combined Modality Therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*; D011838:Radiation-Sensitizing Agents / Q000008:administration & dosage*
D000970:Antineoplastic Agents; D011838:Radiation-Sensitizing Agents