Hemorheological factors of oxygen transfer in capillary tissue unit.
The supply of oxygen to tissue from capillaries may be influenced by hemorheological factors. A hemorheological model is developed for elucidating which factors play a major role in the oxygen transport to tissue. For a capillary tissue unit, a modified cylindrical model of Krogh is used. For blood, two fluids model of red blood cells (RBCs) and plasma is used where hemoglobin release effect is included. Non-equilibrium flows as well as equilibrium flows are examined for various parameters (total flow Q or RBC velocity Vr, discharge hematocrit Hd and capillary hematocrit Hc). In equilibrium flow, Hd and Q determine the oxygen transport. In non-equilibrium flow, Hc also becomes important. Especially, hemoglobin release effect becomes significant in low Hc flow, which affects the area of lethal region in tissue.
D002196:Capillaries / Q000502:physiology*; D004912:Erythrocytes / Q000502:physiology; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D008433:Mathematics; D008955:Models, Cardiovascular; D010100:Oxygen / Q000097:blood*; D010313:Partial Pressure; D010949:Plasma / Q000502:physiology; D012039:Regional Blood Flow; D012212:Rheology
D006454:Hemoglobins; D010100:Oxygen