[Prognostic significance of cellular stromal reaction at the tumor margin and the reaction in the regional lymph nodes in rectal adenocarcinoma. Patient follow-up studies after curative abdominoperineal rectal amputation].
A significant correlation was found between the prognosis, expressed by the tumorfree survival time after resection of the rectum and the stage of tumor, the grading of histological differentiation, and the cellular stromal infiltration at the margin of the tumor. The stage of the tumor ranked first in influence on prognosis followed, unexpectedly, by the granulocytic stromal reaction, relative lymphocyte value in the peripheral blood, the histological grading, and the adjuvant therapy variants. The prognostic relevance of the immunologic reactions in the regional lymph nodes (follicular hyperplasia, paracortical macrophage activity, sinushistiocytosis) and of the round-cellular stromal reaction at the margin of the tumor can be seen in the correlation analysis but is no longer evident in the steplike multiple regression analysis.
D000230:Adenocarcinoma / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D005500:Follow-Up Studies; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology*; D008207:Lymphatic Metastasis; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012004:Rectal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D012007:Rectum / Q000473:pathology* / Q000601:surgery; D012044:Regression Analysis
Die prognostische Bedeutung der zellulären Stromareaktion am Tumorrand und der Reaktion in den regionalen Lymphknoten bei Adenokarzinomen des Rektums. Verlaufsstudien bei Patienten nach kurativer abdominoperinealer Rektumamputation.