title: Carcinoma of the large bowel in the first four decades.
abstract: Eighty-five patients aged 40 or less who presented with colorectal carcinoma over a 32-year period were reviewed. The incidence was 2.5 per cent of all patients with large bowel cancer (n = 3426). Predisposing causes included familial polyposis (eight patients), panproctocolitis (ulcerative, one; Crohn's, one) and irradiation (one); four patients were pregnant. One-third of the patients presented as emergencies, and 43 per cent of these had intestinal obstruction. Five-year survival rates were 41 per cent overall and 59 per cent after 'curative' resection. Survival was equivalent both for elective and emergency admission and for mucinous carcinomas (n = 16) and those non-mucinous carcinomas of moderate histological differentiation. Five-year survival rates were poorer when the history was less than three months in duration (20 per cent vs. 45 per cent: P = 0.02) and for rectal and rectosigmoid tumours than colonic tumours (31 per cent vs. 50 per cent: P = 0.05). Radical resection is indicated when feasible: four of five patients with involvement of adjacent viscera and four of six patients with resectable recurrence survived beyond 10 years. The outcome is similar to that at all ages, any unfavourable pathological features being balanced by improved survival following emergency operations.
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis / Q000209:etiology / Q000401:mortality*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000401:mortality*; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local; D011247:Pregnancy; D011379:Prognosis; D012004:Rectal Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000401:mortality*; D013997:Time Factors