Immunological aspects of psoriasis. VI. Impairment of isoprenaline and theophylline-induced inhibition of mitogen responsiveness.
Pharmacological abnormalities occur in the psoriatic epidermis, and if similar abnormalities occur in the peripheral blood mononuclear cells they could impair the immune responses in psoriasis. In a paired control study, we have tested the capacity of histamine, isoprenaline and theophylline (10(-5) and 10(-7) M) to inhibit the mitogen responsiveness of blood mononuclear cells from normal and psoriatic subjects, using phytohaemagglutinin and concanavalin A. In the normal controls, mitogen responsiveness was inhibited by all three pharmacological agents by about 30 to 50%. In cells from psoriatic patients, the response in the presence of histamine was inhibited (as in the controls), but isoprenaline caused no inhibition, and theophylline paradoxically increased the mitogenic responses. These results suggest there is a defect in the pharmacological response of the blood mononuclear cells in psoriasis.
D000328:Adult; D000368:Aged; D001773:Blood Cells / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003208:Concanavalin A / Q000494:pharmacology; D003864:Depression, Chemical; D005260:Female; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D007545:Isoproterenol / Q000494:pharmacology; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology; D011565:Psoriasis / Q000276:immunology*; D013806:Theophylline / Q000494:pharmacology
D010835:Phytohemagglutinins; D003208:Concanavalin A; D006632:Histamine; D013806:Theophylline; D007545:Isoproterenol