Influence of experimental liver injury on rat blood and alveolar bone under stress.
Experimental liver injury was induced to test rats with a daily injection of thioacetamide (ThAA). The doses used for intraperitoneal administrations were 50 mg/kg body weight. The loss of body weight in the 3-week test period was 15%. In the liver there was seen progressive changes which displayed cell necrosis and regeneration. The influence of ThAA on rat blood and serum was checked using standard biochemical assays consisting of the percentage of blood obtainable and the serum/blood ratio and analysis of serum alanine transferase, serum alkaline phosphatase, serum creatinine, and hydroxyproline in the acute, subacute, chronic, and necrotic stage of liver injury. With ThAA injections, the stimulated rate of glycosaminoglycan synthesis had its association to the serum calcium content. It decreased continuously as function of traumatization time. In the 3-week test period, histological findings show in the alveolar bone, around the teeth, when under occlusal stress and ThAA traumatization, the distinct decrease in osteoblastic activity and less osteoids indicating thus the decreased formation of new bone. Conspicuous osteoclastic resorption was also seen in the same area.
D000081:Acetamides / Q000494:pharmacology*; D000539:Alveolar Process / Q000187:drug effects* / Q000648:ultrastructure; D000818:Animals; D001732:Bite Force; D001769:Blood / Q000187:drug effects*; D001835:Body Weight; D003766:Dental Occlusion; D004798:Enzymes / Q000097:blood; D008099:Liver / Q000648:ultrastructure; D008103:Liver Cirrhosis / Q000139:chemically induced*; D008297:Male; D051381:Rats; D013312:Stress, Physiological; D013853:Thioacetamide / Q000494:pharmacology*
D000081:Acetamides; D004798:Enzymes; D013853:Thioacetamide