Protective effects of Na salicylate against digoxin- and BaCl2-induced arrhythmias in guinea-pigs.
In pentobarbital-anaesthetized (60 mg/kg i.p.) guinea-pigs injections of Na salicylate (50 and 100 mg/kg i.v.) had a protective effect against arrhythmias induced by digoxin or BaCl2. A lower (25 mg/kg) and a higher (200 mg/kg) dose exerted no clearcut antiarrhythmic effect. Plasma concentrations of Na salicylate up to 1 mg/ml influenced neither the heart rate nor the ECG parameters. The antiarrhythmic effect of the drug may be explained by an inhibition of cardiac cyclooxygenase.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control*; D001464:Barium / Q000633:toxicity*; D017609:Barium Compounds; D001794:Blood Pressure / Q000187:drug effects; D002712:Chlorides; D004077:Digoxin / Q000633:toxicity*; D004562:Electrocardiography; D006168:Guinea Pigs; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D012980:Sodium Salicylate / Q000627:therapeutic use*
D017609:Barium Compounds; D002712:Chlorides; C024986:barium chloride; D001464:Barium; D004077:Digoxin; D012980:Sodium Salicylate