Immunocytochemical demonstration of a phenobarbital-inducible cytochrome P450 in putative preneoplastic foci of rat liver.
Putative preneoplastic foci of rat liver, so far believed to be deficient in monooxygenases, are shown to contain a cytochrome P450 isoenzyme inducible by phenobarbital. The isoenzyme is also present and appears catalytically active in liver tumors obtained after promotion with phenobarbital and alpha-hexachlorocyclohexane.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D004790:Enzyme Induction; D005260:Female; D006651:Histocytochemistry; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced / Q000378:metabolism* / Q000473:pathology; D009602:Nitrosamines / Q000633:toxicity; D010634:Phenobarbital / Q000494:pharmacology*; D011230:Precancerous Conditions / Q000378:metabolism* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; D009602:Nitrosamines; C002741:N-nitrosomorpholine; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital