[Possibilities for optimizing therapy with theophylline preparations. III. Ventilatory effect and pharmacokinetics of "new" Pulmophyllin].
Investigations comparing the preparations Pulmophylline "new", Pulmophylline and Aminophylline show that Pulmophylline "new" has a position between the two other drugs concerning the ventilatory effect and the pharmacokinetics. The effect of this preparation starts in a slower rate and lasts longer than that of Pulmophylline, the effect decreases in a quicker manner than that of Aminophylline. Replacement of the Ethoxytheophylline by the more efficient Theophylline seems to be the first step for the optimization of this drug-preparation. The diminished rate of side effects of Ethoxytheophylline is connected with an unfavourable pharmacokinetics and a smaller effect, as it is shown by investigations of other authors and by our own results.
D000328:Adult; D000628:Aminophylline / Q000097:blood / Q000627:therapeutic use*; D000983:Antipyrine / Q000097:blood / Q000627:therapeutic use*; D001249:Asthma / Q000188:drug therapy; D004311:Double-Blind Method; D004338:Drug Combinations / Q000097:blood / Q000627:therapeutic use; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007700:Kinetics; D008173:Lung Diseases, Obstructive / Q000188:drug therapy*; D008297:Male; D008657:Metabolic Clearance Rate; D013806:Theophylline / Q000031:analogs & derivatives* / Q000097:blood / Q000627:therapeutic use*
D004338:Drug Combinations; D000628:Aminophylline; C041208:pulmophylline; C041210:pulmophylline (new); D013806:Theophylline; D000983:Antipyrine
Optimierungsmöglichkeiten bei der Therapie mit Theophyllinpräparaten. III. Ventilatorische Wirkung und Pharmakokinetik von Pulmophyllin "neu".