title: [Effect of Fab-fragments of antibodies against spleen cell surface antigens on the development of antibody formation in cultures of different densities].
abstract: The role of surface antigens in the density-dependent inhibition of primary immune response in mouse spleen cell cultures was investigated. For this purpose Fab-fragments of rabbit IgG obtained after immunization with mouse splenocytes were used. Such Fab-fragments alone had no effect on immune response in both optimal and dense cultures. However, successive treatment of cells with Fab-fragments and with ass antibodies against rabbit IgG dramatically augmented the density-dependent inhibition of antibody formation.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000954:Antigens, Surface / Q000276:immunology*; D003470:Culture Media; D007140:Immunoglobulin Fab Fragments / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000276:immunology*
chemical_list: D000954:Antigens, Surface; D003470:Culture Media; D007140:Immunoglobulin Fab Fragments
vernacular_title: Vliianie Fab-fragmentov antitel protiv poverkhnostnykh antigenov kletok selezenki na razvitie antiteloobrazovaniia v kul'turakh raznoĭ plotnosti.