A new approach of ordered mixing applied to digitoxin tablets.
In ordered mixing it is assumed that mixing very different amounts of two materials is improved by adsorption of small particles onto large carrier particles. This hypothesis could be confirmed with tablets of 120 mg containing 0.1 mg digitoxin, prepared by dry coating of particles.
D000327:Adsorption; D002266:Carboxymethylcellulose Sodium; D004074:Digitoxin; D004339:Drug Compounding; D005079:Excipients; D010316:Particle Size; D013050:Spectrometry, Fluorescence / Q000379:methods; D013607:Tablets
D005079:Excipients; D013607:Tablets; D004074:Digitoxin; D002266:Carboxymethylcellulose Sodium