Stimulation of dopamine autoreceptors elicits "premature ejaculation" in rats.
Following treatment with dopamine (DA) receptor agonists, such as apomorphine, N-n-propyl-norapomorphine, lisuride and 3-(3-hydroxyphenyl)-N-n-propyl-piperidine (3-PPP) (50, 2.5, 400 and 5000 micrograms/kg, respectively), male rats attain ejaculation with receptive females sooner and after fewer penile intromissions than controls. Since doses of DA agonists needed to produce "premature ejaculation" are within the low dose range needed to stimulate DA autoreceptors, it is suggested that "premature ejaculation" in rats results from inhibition of DA neurotransmission. This hypothesis is supported by the finding that 6 hr after haloperidol (1 mg/kg), rats achieve ejaculation after fewer intromissions than normal.
D000818:Animals; D001058:Apomorphine / Q000031:analogs & derivatives / Q000494:pharmacology; D003307:Copulation / Q000502:physiology; D004294:Domperidone / Q000494:pharmacology; D018492:Dopamine Antagonists; D004542:Ejaculation / Q000187:drug effects*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D008090:Lisuride / Q000494:pharmacology; D008297:Male; D010880:Piperidines / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology; D012726:Sexual Behavior, Animal / Q000187:drug effects*
D018492:Dopamine Antagonists; D010880:Piperidines; D011954:Receptors, Dopamine; D004294:Domperidone; C009074:N-n-propylnorapomorphine; C026539:preclamol; D008090:Lisuride; D006220:Haloperidol; D001058:Apomorphine