title: Regional mapping of clotting factors VII and X to 13q34. Expression of factor VII through chromosome 8.
abstract: Blood clotting factors were investigated in a patient with trisomy 8 mosaicism, a patient with an r(13), and a patient with distal trisomy 13q. Results are compatible with the assignment of the structural genes of factors VII and X to 13q34 and the existence of a regulatory mechanism associated with chromosome 8 controlling the expression of factor VII alone.
mesh_terms: D000328:Adult; D001780:Blood Coagulation Tests; D002675:Child, Preschool; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002901:Chromosomes, Human, 13-15; D002906:Chromosomes, Human, 6-12 and X; D005167:Factor VII / Q000235:genetics*; D005168:Factor VII Deficiency / Q000097:blood / Q000235:genetics; D005170:Factor X / Q000235:genetics*; D005171:Factor X Deficiency / Q000097:blood / Q000235:genetics; D005260:Female; D005786:Gene Expression Regulation; D005796:Genes; D005809:Genes, Regulator; D006801:Humans; D007223:Infant; D007621:Karyotyping; D014314:Trisomy
chemical_list: D005167:Factor VII; D005170:Factor X