Lek a, a new platelet antigen absent in Glanzmann's thrombasthenia.
The serum of a patient who developed a posttransfusion purpura contained antibodies directed against a previously undescribed platelet antigen Lek a. The antiplatelet activity was present in the IgG fraction and was detected by immunofluorescence, 51Cr lysis and 14C-serotonin release. The frequency of the Lek a phenotype in the French population is 98.18%. Lek a does not appear to be sex-linked and seems to be closely related to the Bak a antigen. The Lek a antigen is not expressed on thrombasthenic platelets but is found on platelets from patients with the Bernard-Soulier syndrome which suggests that this antigen is carried by platelet glycoproteins IIb and/or IIIa.
D000328:Adult; D000918:Antibody Specificity; D016824:Antigens, Human Platelet; D001791:Blood Platelet Disorders / Q000097:blood / Q000235:genetics / Q000276:immunology*; D001792:Blood Platelets / Q000276:immunology*; D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000302:isolation & purification; D007519:Isoantigens / Q000235:genetics*; D008297:Male; D010375:Pedigree; D011693:Purpura / Q000209:etiology; D065227:Transfusion Reaction
C044561:3a alloantigen, human; D016824:Antigens, Human Platelet; D007518:Isoantibodies; D007519:Isoantigens