Hyperalgesic activity of parathyroid hormone and its fragments in male rats.
Results presented in this paper indicate that intracerebroventricular injection of parathyroid hormone reduces pain threshold in male rats. This effect is induced by whole molecule (84 amino acids) or by fragments 1-34 and 44-68 of PTH. The fragment 65-84 of PTH does not induce any change in pain threshold.
D000818:Animals; D004056:Differential Threshold; D006930:Hyperalgesia / Q000139:chemically induced*; D006941:Hyperesthesia / Q000139:chemically induced*; D007276:Injections, Intraventricular; D008297:Male; D010146:Pain / Q000503:physiopathology; D010281:Parathyroid Hormone / Q000494:pharmacology*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time
D010281:Parathyroid Hormone; D010446:Peptide Fragments