Nonopiate effects of alpha-neo-endorphin on mouse behavior using multi-dimensional behavioral analyses.
The effects of alpha-neo-endorphin on mouse behavior were investigated by using a multi-dimensional behavioral analyser (Animex II) which classifies animal's movements into nine degrees. The intracerebral injection of alpha-neo-endorphin (30 micrograms) significantly decreased the 1/1, 1/2 and 1/4 sizes of movement (linear locomotion and rearing) within 15 min after injection. None of the effects were significantly affected by naloxone even at high doses. The results suggest that a behaviorally active site within the alpha-neo-endorphin sequence is capable of quite potent but nonopiate effects.
D000818:Animals; D004723:Endorphins / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology; D011498:Protein Precursors / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D004723:Endorphins; D011498:Protein Precursors; D009270:Naloxone; C025681:alpha-neoendorphin