Age-related changes in unscheduled DNA synthesis by rat hepatocytes.
Ultraviolet-induced unscheduled DNA synthesis was studied as a function of age in hepatocytes isolated from 6- to 32-months-old rats. Unscheduled DNA synthesis was measured by both DNA specific activity and autoradiography. Using both procedures, a significant decline in unscheduled DNA synthesis was observed after 14 months of age.
D000375:Aging; D000818:Animals; D001345:Autoradiography; D004247:DNA / Q000096:biosynthesis* / Q000528:radiation effects; D004260:DNA Repair; D004307:Dose-Response Relationship, Radiation; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D014466:Ultraviolet Rays
D004247:DNA