Unusually high susceptibility of NZR/Gd rats to bladder cancer induction by low doses of nitrosomethylurea.
Inbred female rats of the NZR/Gd strain were exceptionally susceptible to nitrosomethylurea (NMU) toxicity after intravesical instillations. After only 1.0 mg NMU total given in 10 fractions, 100% of NZR rats developed malignant bladder tumours. Transitional cell carcinomas predominated (56%) when the NMU dose interval was 2 weeks, and most tumours were squamous carcinomas (57%) with a 1-week interval.
D000818:Animals; D002277:Carcinoma / Q000139:chemically induced* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced; D004198:Disease Susceptibility; D005260:Female; D008770:Methylnitrosourea / Q000633:toxicity*; D009607:Nitrosourea Compounds / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000473:pathology; D014546:Urinary Catheterization
D009607:Nitrosourea Compounds; D008770:Methylnitrosourea