Synthesis of new 8-(5-substituted amino-1,3,4-oxadiazol-2-yl) and 8-(5-substituted amino-1,3,4-thiadiazol-2-yl) methoxyquinolines with antibilharzial activity.
Several 5-substituted amino-1,3,4-oxadiazol-2-yl and 5-substituted amino-1,3,4-thiadiazol-2-yl derivatives with different 8-hydroxyquinoline moieties in the 2-position were prepared and tested for their antiparasitic activity. Preliminary biological tests on mice experimentally infested with Schistosoma mansoni revealed that the new compounds show moderate schistosomicidal activity.
D000818:Animals; D006826:Hycanthone / Q000627:therapeutic use; D006912:Hydroxyquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D007421:Intestine, Small / Q000469:parasitology; D008099:Liver / Q000469:parasitology; D051379:Mice; D010069:Oxadiazoles / Q000138:chemical synthesis / Q000494:pharmacology; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000188:drug therapy; D012556:Schistosomicides / Q000138:chemical synthesis*; D013830:Thiadiazoles / Q000138:chemical synthesis / Q000494:pharmacology
D006912:Hydroxyquinolines; D010069:Oxadiazoles; D012556:Schistosomicides; D013830:Thiadiazoles; D006826:Hycanthone