title: [Effects of a natural estrogen, estradiol, on hemostasis in guinea pigs].
abstract: 17-beta-estradiol was administered weekly to female guinea-pigs at the dosage of 2-3 mg/kg body weight during 4-6 weeks. Compared to a control population, no significant effect was observed on: recalcification time; thromboelastography; PTT; APTT; Quick one stage prothrombin time; antigenic and active plasma fibrinogen level; antithrombin III level; factor XI level; red and white blood cell count. A significant increase in levels of factor II (+25%), of factor V, of factor XII (+40%) and a decrease in levels of complex VII + X was observed. Values for AT III, factor XII, chronometric and immunologic fibrinogen plasma levels, unknown until now for the guinea-pig, were established.
mesh_terms: D000818:Animals; D001779:Blood Coagulation Factors / Q000032:analysis; D001780:Blood Coagulation Tests; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D006487:Hemostasis / Q000187:drug effects*; D008099:Liver / Q000473:pathology; D008297:Male
chemical_list: D001779:Blood Coagulation Factors; D004958:Estradiol
vernacular_title: Effets d'un oestrogène naturel, l'oestradiol sur l'hémostase du cobaye.