title: Malathion toxicity: in vivo inhibition of acetylcholinesterase in the fish Brachydanio rerio (Cyprinidae).
abstract: Acetylcholinesterase (AChE) activity in the nervous tissue (brain) of the fish Brachydanio rerio was significantly inhibited by exposure to the organophosphorus (OP) pesticide, malathion. The inhibition was dose- as well as time-dependent. The fish survived even when the activity of the enzyme was inhibited by 90%. There was a significant recovery in the activity of AChE when malathion stress was lifted.
mesh_terms: D000818:Animals; D001921:Brain / Q000201:enzymology; D002800:Cholinesterase Inhibitors; D005399:Fishes / Q000378:metabolism*; D008294:Malathion / Q000633:toxicity*
chemical_list: D002800:Cholinesterase Inhibitors; D008294:Malathion