Chemotherapy as an alternative to laminectomy and radiation in the management of epidural tumor.
Nine children with neuroblastoma and five with Ewing sarcoma were found at diagnosis to have epidural extension of tumor. Five children underwent laminectomy prior to referral, with good neurologic recovery in only one. Management in the other nine children did not include laminectomy. All 14 patients were given chemotherapy without radiotherapy. Rapid regression of tumor with neurologic recovery occurred in response to chemotherapy in all patients with neurologic deficits. The responses observed in these children indicate that for chemotherapy-sensitive tumors, effective chemotherapy is a feasible alternative to laminectomy and radiation therapy in the management of epidural disease.
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004824:Epidural Space; D006801:Humans; D007223:Infant; D007796:Laminectomy; D008479:Mediastinal Neoplasms; D009447:Neuroblastoma / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D012512:Sarcoma, Ewing / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery; D013120:Spinal Cord Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000556:secondary / Q000601:surgery