3-methylindole as a model of equine obstructive lung disease.
3-methylindole was administered orally and intravenously to horses and ponies in order to determine the ability of this chemical to provide a model of equine pulmonary disease. Both routes produced a severe and sometimes fatal pulmonary disease, characterised by bronchiolitis. Clinical signs developed 48 to 72 h after dosing and were most severe between Days 4 and 10 post dosing. Intravenous administration of 3-methylindole produced lung injury more rapidly and at a lower dose rate than the oral route. It is suggested that the respiratory condition induced by this chemical could become a method for standardisation of lung function techniques and interpretation in equine obstructive pulmonary disease.
D000818:Animals; D001980:Bronchi / Q000473:pathology; D004195:Disease Models, Animal; D006734:Horse Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D006736:Horses; D007211:Indoles / Q000633:toxicity; D008173:Lung Diseases, Obstructive / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology / Q000662:veterinary*; D008297:Male; D012119:Respiration; D012862:Skatole / Q000633:toxicity
D007211:Indoles; D012862:Skatole