title: Effect of Iodide, methimazole, and thyroxine on thyroidal accumulation of radioiodide in immature domestic fowl.
abstract: Accumulation of radioiodide by the thyroids of individual domestic fowl was measured with the technique described by T. F. Davison, J. G. Rowell, and J. Rea, [1981) J. Endocrinol. 89, 371-378). Radioiodide uptake was markedly decreased in birds given an excess of iodide in the drinking water (60 mg KI/liter) or injections of thyroxine (T4: 5 X 50 micrograms T4/kg body wt), in agreement with published findings. Treatment with a goitrogen (250 mg methimazole/liter drinking water) decreased 125I uptake for at least 8 days but thereafter uptake increased and this was accompanied by gross thyroidal enlargement. The results indicate that the thyroid partly compensates for goitrogenic inhibition.
mesh_terms: D000818:Animals; D002645:Chickens / Q000378:metabolism*; D005260:Female; D007454:Iodides / Q000494:pharmacology*; D007457:Iodine Radioisotopes / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000187:drug effects; D008297:Male; D008713:Methimazole / Q000494:pharmacology*; D011877:Radionuclide Imaging; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000187:drug effects / Q000378:metabolism*; D013974:Thyroxine / Q000097:blood / Q000494:pharmacology*
chemical_list: D007454:Iodides; D007457:Iodine Radioisotopes; D008713:Methimazole; D013974:Thyroxine