[Preliminary observations, at the ultrastructural level, on the reactivity of cerebral arteries from New Zealand rabbits to combined atherogenic stimuli (hypercholesterol diet and hypertension)].
Both in monkeys (Rhesus and Cynomolgus) and in New Zealand rabbits fed an atherogenic diet, a marked delay in the appearance of atherosclerotic lesions of the cerebral arteries in comparison with other arterial districts has been observed. This appearance has been described in monkeys as relatively earlier if hypertension is added to the atherogenic diet. Preliminary observations on a little group of rabbits on a 3 months hypercholesterolic diet, subjected to Goldblatt aortic coarctation, have shown an increase of blood pressure and a severe gross atherosclerotic involvement of aorta, resembling the one obtainable after 6 months of atherogenic diet. Histologically, the aorta predominantly shows lesions of the fatty streaks type with necrotic areas in the deep; the carotid lesions show some lipid in smooth muscle cells disseminated in a sub-endothelial "edematous" space (rich in protein). The cerebral arteries do not show any lesion. At TEM, the aortic lesions look sometimes as advanced plaques with an initial fibrosis at the surface; the carotid lesions are characterized by a granular deposit in the sub-endothelial space in which some smooth muscle cells (with lipid in the cytoplasm) are present; in the cerebral arteries only the presence of collagen fibers among the smooth muscle cells of the media, never observed in the animals fed the atherogenic diet alone, has sometimes been noted.
D000818:Animals; D001161:Arteriosclerosis / Q000473:pathology; D002536:Cerebral Arteries / Q000648:ultrastructure*; D004036:Diet, Atherogenic; D006937:Hypercholesterolemia / Q000473:pathology*; D006973:Hypertension / Q000473:pathology*; D008252:Macaca fascicularis; D008253:Macaca mulatta; D008854:Microscopy, Electron; D011817:Rabbits
Osservazioni preliminari, a livello ultrastrutturale, sulla reattivita' delle arterie cerebrali di coniglio New Zealand a stimoli aterogeni combinati (dieta ipercolesterolica e ipertensione).