title: Opiate antagonists reverse the hypoactivity associated with systemic anaphylaxis in mice.
abstract: Systemic anaphylaxis in the mouse is associated with marked hypoactivity. This effect is reversed by treatment with the opiate antagonists, naloxone (5-10 mg/kg) or naltrexone (1 mg/kg). Administration of naltrexone methyl bromide (1 mg/kg), a selective peripherally acting opiate antagonist, is ineffective in reversing the hypoactivity induced by anaphylaxis. These results suggest a role for central nervous system opiate mechanisms in the hypoactivity induced by anaphylaxis. They support the hypothesis that endogenous opiates contribute to the pathophysiologic consequences of anaphylactic shock.
mesh_terms: D000707:Anaphylaxis / Q000523:psychology*; D000818:Animals; D007276:Injections, Intraventricular; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009043:Motor Activity / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology; D009271:Naltrexone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology*
chemical_list: D009292:Narcotic Antagonists; D009270:Naloxone; D009271:Naltrexone