A perfluorochemical emulsion as an oxygen carrier.
Fluosol-DA 20%, a perfluorochemical emulsion consisting of 7 parts perfluorodecalin (FDC) and 3 parts perfluorotripropylamine (FTPA), has been used as an oxygen carrier in clinical studies. The emulsion, however, must be stored frozen because it is not stable for long in a liquid state. To increase the stability of perfluorochemical emulsions, a series of experiments on stability, elimination, and toxicity were conducted on different perfluorochemicals. F-4-Methyloctahydroquinolidizine (FMOQ) was selected as the best material. The tissue half-life of FMOQ in rats was estimated to be 7 days, which is the same as that of FDC, a perfluorochemical in Fluosol-DA 20%. FMOQ emulsified with a mixture of yolk phospholipid and Pluronic F-68 was stable at 4 degrees C for 6 months. Rats exchange-transfused to a hematocrit of 4% with this emulsion survived for 13 weeks.
D000818:Animals; D001802:Blood Substitutes / Q000378:metabolism / Q000494:pharmacology*; D004338:Drug Combinations / Q000494:pharmacology; D005078:Exchange Transfusion, Whole Blood; D005466:Fluorocarbons / Q000378:metabolism / Q000494:pharmacology* / Q000633:toxicity / Q000652:urine; D006895:Hydroxyethyl Starch Derivatives; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D001802:Blood Substitutes; D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination