Changes of acetylcholine, catecholamines and amino acid in mice brain following treatment with Nuvacron and Furadan.
The effects of multiple intraperitoneal doses of Nuvacron (0.8 mg/kg) or Furadan (0.25 mg/kg) on the concentrations of brain neurotransmitters in mice were studied. The following were measured: acetylcholine, acetylcholinesterase, gamma-aminobutyric acid, epinephrine, norepinephrine, dopamine and 5-hydroxytryptamine. These pesticides caused a significant decrease in acetylcholinesterase activity and a significant increase in acetylcholine, gamma-amino-butyric acid, epinephrine, norepinephrine, dopamine and 5-hydroxy tryptamine concentrations. The increased concentrations of the neurotransmitters in mouse brain might be associated with CNS depressant action induced by the insecticides.
D000109:Acetylcholine / Q000378:metabolism*; D000110:Acetylcholinesterase / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D002235:Carbofuran / Q000633:toxicity*; D002395:Catecholamines / Q000378:metabolism*; D002800:Cholinesterase Inhibitors / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity*; D051379:Mice; D008999:Monocrotophos / Q000633:toxicity*; D012701:Serotonin / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000596:Amino Acids; D002395:Catecholamines; D002800:Cholinesterase Inhibitors; D007306:Insecticides; D012701:Serotonin; D005680:gamma-Aminobutyric Acid; D008999:Monocrotophos; D000110:Acetylcholinesterase; D000109:Acetylcholine; D002235:Carbofuran