Renal cell carcinoma--xenotransplantation into immuno-suppressed mice.
21 human renal cell carcinomas (RCC) were xenotransplanted into artificially immunosuppressed mice. 4 tumors grew successfully retaining some characteristics of the primary tumors (according to morphology and karyotype analysis), but losing metastatic capacity. One of the serially transplantable tumors (HT 40) with hyperdiploid cellular DNA content and estrogen receptor positivity failed to respond to the single maximally tolerated dose of several cytotoxic agents.
D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004351:Drug Resistance; D005260:Female; D005434:Flow Cytometry; D006085:Graft Survival; D006801:Humans; D007165:Immunosuppression Therapy; D007621:Karyotyping; D007680:Kidney Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008875:Middle Aged; D009368:Neoplasm Transplantation; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D014183:Transplantation, Heterologous
D000970:Antineoplastic Agents; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone