Chloramphenicol sodium succinate in the horse: serum, synovial, peritoneal, and urine concentrations after single-dose intravenous administration.
Six healthy adult mares were given a single IV dose (25 mg/kg of body weight) of chloramphenicol sodium succinate. Chloramphenicol concentrations in serum, synovial fluid, peritoneal fluid, and urine were measured serially over a 48-hour period. The highest measured serum chloramphenicol concentration was 6.21 micrograms/ml at 0.5 hour. Chloramphenicol was detected in synovial and peritoneal fluids, with mean peak concentrations of 3.89 micrograms/ml and 3.50 micrograms/ml, respectively, at 0.5 hour. Serum and synovial concentrations declined rapidly and were not measurable at 3 hours. Chloramphenicol could not be detected in peritoneal fluid at 6 hours. The serum half-life was 0.43 hour and the apparent volume of distribution was 2.83 L/kg. Urine concentrations of chloramphenicol peaked at 0.5 hour at 106.72 micrograms/ml and also declined rapidly. The drug could not be detected in the urine at 36 hours.
D000818:Animals; D002701:Chloramphenicol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000032:analysis / Q000652:urine; D005260:Female; D006736:Horses / Q000378:metabolism* / Q000652:urine; D007275:Injections, Intravenous / Q000662:veterinary; D010537:Peritoneum / Q000032:analysis; D013582:Synovial Fluid / Q000032:analysis
D002701:Chloramphenicol; C026016:chloramphenicol succinate