Poly(d2NH2A-dT): effect of 2-amino substituent on the B to Z transition.
The effect of 2-amino substitution in adenosine (which permits formation of three hydrogen bonds to T) on the B to Z transition was examined in synthetic DNA of alternating purine-pyrimidine sequence. Results of CD, IR, and 31P NMR experiments show that (d2NH2A-dT)n undergoes a cooperative transition to a different helical structure under the same conditions as the B to Z transition of (dG-dC)n.
D015075:2-Aminopurine / Q000031:analogs & derivatives*; D000225:Adenine / Q000031:analogs & derivatives*; D002942:Circular Dichroism; D009682:Magnetic Resonance Spectroscopy; D009690:Nucleic Acid Conformation; D011067:Poly dA-dT; D011089:Polydeoxyribonucleotides; D013055:Spectrophotometry, Infrared; D013329:Structure-Activity Relationship
D011089:Polydeoxyribonucleotides; D011067:Poly dA-dT; D015075:2-Aminopurine; C007300:2,6-diaminopurine; D000225:Adenine