Removal defect of very-low-density lipoproteins from diabetic rats.
The disappearance rate of triacyl[3H]glycerol carried on very-low-density lipoproteins (VLDL), isolated from diabetic rats and reinjected into normal recipient rats, was about twice as low as that of VLDL-triacyl[3H]glycerol from non-diabetic rats. The VLDL derived from diabetic rats was deficient in the apolipoprotein E component. These results indicate that the triacylglycerol removal defect in diabetes may be related to the quality of the protein carrier.
D000818:Animals; D001053:Apolipoproteins / Q000378:metabolism; D001057:Apolipoproteins E; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D008079:Lipoproteins, VLDL / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D051381:Rats; D014280:Triglycerides / Q000378:metabolism
D001053:Apolipoproteins; D001057:Apolipoproteins E; D008079:Lipoproteins, VLDL; D014280:Triglycerides