[Isolation of immunoglobulin G--marker of normal growth in the blood of the rat].
The blood of rats with a regenerating liver and of pregnant animals is found to contain a peculiar subfraction of immunoglobulin G (IgG) which is absent in the blood of control animals. A characteristic feature of the protein which permits its detection among other proteins of this class, is its ability to form a complex with serum alpha-globulins insoluble in the acid medium. The complex in composition and conditions of formation differs from that formed by IgG typical of malignant growth. This shows that in blood of animals with normal and malignant growth there appears a subfraction of IgG with similar properties but not identical to it. Isolation of the studied IgG from the formed complex insoluble in the acid medium is suggested as a preparative method for obtaining its subpopulation.
D000818:Animals; D002848:Chromatography, DEAE-Cellulose; D002850:Chromatography, Gel; D005260:Female; D007122:Immunoelectrophoresis; D007074:Immunoglobulin G / Q000302:isolation & purification*; D008115:Liver Regeneration; D009374:Neoplasms, Experimental / Q000097:blood; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats
D007074:Immunoglobulin G
Vyiavlenie immunoglobulina G--markera normal'nogo rosta v krovi krys.