title: Mania induced by metoclopramide: case report.
abstract: A case is reported in which a patient became manic while taking metoclopramide, a drug which affects several neurotransmitter systems. The apparent relationship between the manic symptoms and metoclopramide was strengthened by a placebo period with no such symptoms, followed by recurrence upon rechallenge. Amitriptyline blunted the manic response.
mesh_terms: D000639:Amitriptyline / Q000494:pharmacology / Q000627:therapeutic use; D001714:Bipolar Disorder / Q000139:chemically induced* / Q000188:drug therapy; D004347:Drug Interactions; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D005767:Gastrointestinal Diseases / Q000188:drug therapy; D006801:Humans; D008787:Metoclopramide / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged
chemical_list: D000639:Amitriptyline; D008787:Metoclopramide