title: Distribution and characterization of cyclo (His-Pro)-like immunoreactivity in anuran (frog) skins.
abstract: The distribution of cyclo (His-Pro)-like immunoreactivity in frog skins from seven frog species was examined. The chromatographic elution profile of cyclo (His-Pro)-like immunoreactivity in amphibian skins measured by radioimmunoassay corresponded precisely to that of [3H-Pro]-cyclo (His-Pro) after DEAE-Cellulose, Sephadex G-25 and high-pressure liquid chromatography. The concentrations of cyclo (His-Pro) in frog skins were much higher than the concentrations of TRH previously observed in skin and the concentrations of cyclo (His-Pro) in both brain and gastrointestinal tract.
mesh_terms: D000818:Animals; D001001:Anura / Q000378:metabolism*; D010456:Peptides, Cyclic / Q000032:analysis*; D010879:Piperazines / Q000032:analysis*; D011863:Radioimmunoassay / Q000379:methods; D011898:Ranidae / Q000378:metabolism; D012867:Skin / Q000032:analysis*; D013045:Species Specificity
chemical_list: D010456:Peptides, Cyclic; D010879:Piperazines; C015924:histidyl-proline diketopiperazine