TAG antagonises the central cardiovascular effects of taurine.
The taurine antagonist TAG was examined for its blocking activity towards the central cardiovascular effects of taurine and muscimol. Intracerebroventricular (i.c.v.) injections of taurine (1-1000 micrograms/kg) and muscimol (0.1-3 micrograms/kg) in the anesthetised cat led to hypotension and bradycardia. Pretreatment with TAG (1 mg/kg i.c.v.) antagonised the blood pressure effects of taurine. The selectivity of this antagonism is discussed since TAG also shifted to the right the blood pressure dose-response curve obtained with muscimol.
D000818:Animals; D001581:Benzothiadiazines / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000502:physiology; D002415:Cats; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects*; D009118:Muscimol / Q000037:antagonists & inhibitors; D013654:Taurine / Q000037:antagonists & inhibitors*
D001581:Benzothiadiazines; D013654:Taurine; D009118:Muscimol; C032946:6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide