Some pharmacological studies on a new tripeptide mustard.
The analgesic, spasmolytic, antiinflammatory, C.N.S., cardiovascular, respiratory, and anaphylactogenic activities of PTT-119 were investigated. PTT-119 possesses good peripheral but only slight central analgesic activity. It presents an interesting in vitro spasmolytic activity of non-competitive type against acetylcholine and histamine. PTT-119 is inactive in rat carrageenin oedema, on the C.N.S. of mice, on cardiovascular and respiratory parameters of cats, and in guinea-pig anaphylaxis.
D000700:Analgesics; D000707:Anaphylaxis / Q000517:prevention & control; D000818:Animals; D000893:Anti-Inflammatory Agents; D002415:Cats; D002490:Central Nervous System / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology*; D010276:Parasympatholytics; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D009588:Nitrogen Mustard Compounds; D010276:Parasympatholytics; C038259:ambamustine