Dopamine applied into the nucleus accumbens and discriminative avoidance in rats.
The actions of dopamine (DA) administered into the nucleus accumbens on motor function and discrimination were examined in rats trained to perform a discriminative conditioned avoidance response (DCAR). alpha-Methyl-p-tyrosine was found to suppress performance of the CAR although it did not impair discrimination. The administration of DA reinstated CAR performance but it also increased discriminative errors. Multivariate comparisons suggested that both of these effects were closely related to the stimulation of intertrial crossings by DA.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004193:Discrimination Learning / Q000187:drug effects*; D004298:Dopamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012686:Septal Nuclei / Q000502:physiology*; D013997:Time Factors; D019805:alpha-Methyltyrosine
D008781:Methyltyrosines; D019805:alpha-Methyltyrosine; D004298:Dopamine