Surgical use of fluosol-DA in Jehovah's Witness patients.
The effects of Fluosol-DA 20% on circulating blood cells, hemodynamic parameters, blood gases, and organs are described and compared with the results of phase I human studies and animal experiments. Bleeding of preoperative anemia and/or surgical bleeding, Fluosol-DA 20% was administered to 7 of 10 Jehovah's Witness patients treated in this hospital. Six received 1,000 ml and the seventh received 2,000 ml. Hematological changes were examined after the administration of a 1-ml test dose and at early and late stages of Fluosol-DA 20% administration. Hemodynamics and blood gases were measured before and after infusion of Fluosol-DA 20%. Hepatic function was also determined. A drop in neutrophils and platelets was observed in some patients after the injection of a 1-ml test dose. This transient reaction was of short term, and the neutrophil and platelet levels recovered spontaneously. Both the efficacy and the safety of Fluosol-DA 20% were demonstrated in these patients.
D000328:Adult; D000368:Aged; D001773:Blood Cells / Q000187:drug effects; D001784:Blood Gas Analysis; D002835:Christianity; D004338:Drug Combinations / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005466:Fluorocarbons / Q000494:pharmacology / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives; D008297:Male; D008875:Middle Aged; D013514:Surgical Procedures, Operative
D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination