Ethanol consumption and serum lipid profiles in Sinclair(S-1) miniature swine.
Ethanol consumption was correlated with changes in acyl group profiles of phosphatidylcholine and triacylglycerols in serum of Sinclair(S-1) miniature boars. Serum triacylglycerols in the control pigs were high in linoleate (18:2) (48%) and low in stearate (18:0 (3%). Upon feeding with 10% (w/v) ethanol ad lib for two weeks, the proportion of 18:2 in serum triacylglycerols decreased to 12-15% with a concomitant increase in 16:0, 18:0 and 18:1. Similar, but less extensive, acyl group changes were observed in the serum phosphatidylcholine. In addition, there was a decrease in the proportion of 20:3(n-6), but a biphasic change was shown in 20:4(n-6) with respect to ethanol consumption. In general, the high ethanol consumers (7.0 g/kg/day) indicated a more rapid rate of acyl group change than the low consumers (3.8 g/kg/day). Upon withdrawal of ethanol, acyl groups of triacylglycerols rapidly returned towards the control values, whereas only small changes were observed for the recovery in phospholipids. In this situation, the low-consumer group indicated a more rapid recovery than the high-consumer group. Results indicate that with the swine model, serum lipid changes can be a useful parameter for correlating biological changes upon ethanol consumption.
D000428:Alcohol Drinking / Q000502:physiology*; D000818:Animals; D002784:Cholesterol / Q000097:blood; D005227:Fatty Acids / Q000097:blood; D008297:Male; D010713:Phosphatidylcholines / Q000097:blood*; D013552:Swine; D013556:Swine, Miniature / Q000097:blood*; D014280:Triglycerides / Q000097:blood*
D005227:Fatty Acids; D010713:Phosphatidylcholines; D014280:Triglycerides; D002784:Cholesterol