Acid phosphatase-producing androgen-independent subline of rat prostatic adenocarcinoma (Dunning R3327 tumor) in cell culture.
Establishment of a cell line derived from the androgen-independent subline of rat prostatic adenocarcinoma (Dunning R3327 tumor) is reported. Cells of this line produced acid phosphatase. When the cultured cells were transplanted to Copenhagen rats, solid tumors were formed. Histologically, the tumor consisted of spindle-shaped, large and bizarre polygonal cells; this feature was almost identical to that of the original tumor. Chromosomes were in the triploid range with seven frequently appearing marker chromosomes.
D000135:Acid Phosphatase / Q000096:biosynthesis*; D000230:Adenocarcinoma / Q000201:enzymology* / Q000473:pathology; D000728:Androgens / Q000502:physiology*; D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D007621:Karyotyping; D008297:Male; D009368:Neoplasm Transplantation; D011471:Prostatic Neoplasms / Q000201:enzymology* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D014410:Tumor Stem Cell Assay
D000728:Androgens; D000135:Acid Phosphatase