Hypercalcemia with elevated dihydroxycholecalciferol levels and hypercalciuria. A parathyroid concentration-independent mechanism.
A 22-year-old man with renal stones had persistent hypercalcemia with massive idiopathic hypercalciuria due to a primary renal tubular phosphorus leak. He did not have hyperparathyroidism or sarcoidosis but did have an elevated dihydroxycholecalciferol level, which contributed to his hypercalcemia.
D000328:Adult; D002118:Calcium / Q000652:urine*; D004100:Dihydroxycholecalciferols / Q000097:blood*; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology*; D007669:Kidney Calculi / Q000150:complications; D007684:Kidney Tubules / Q000503:physiopathology; D008297:Male; D010280:Parathyroid Glands / Q000502:physiology; D010710:Phosphates / Q000097:blood
D004100:Dihydroxycholecalciferols; D010710:Phosphates; D002118:Calcium