Effect of metoclopramide on ureteral motility.
Metoclopramide, a procainamide derivative that markedly stimulates peristalsis in a variety of gastrointestinal tissues, demonstrated a significant dose-dependent effect on rat, canine, and human ureters studied in vitro. A moderate increase in phasic activity was seen at low concentrations with striking inhibition noted at higher concentrations. In the dog, atropine 0.6 microgram/ml inhibited the former while procaine 400 micrograms/ml stimulated the latter. Surgically produced, chronically dilated canine ureters were also stimulated by metoclopramide. Metoclopramide may be useful in states of disordered ureteral motility.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D066298:In Vitro Techniques; D008787:Metoclopramide / Q000494:pharmacology*; D009068:Movement / Q000187:drug effects*; D011343:Procaine / Q000494:pharmacology; D051381:Rats; D014513:Ureter / Q000502:physiology*; D014517:Ureteral Obstruction / Q000503:physiopathology
D011343:Procaine; D001285:Atropine; D008787:Metoclopramide