The alterations in H1 histone complement during mouse spermatogenesis and their significance for H1 subtype function.
The principal histone H1 subtypes of mouse prepachytene spermatocytes were identified as H1a and H1c, proteins that are metabolically unstable and have been postulated to promote extended or flexible chromatin conformations. We suggest that the unusual H1 subtype composition in these cells favors chromatin conformations compatible with the precise chromosomal pairing necessary for genetic recombination and also that it may expedite histone replacement during spermiogenesis.
D000375:Aging; D000818:Animals; D005075:Biological Evolution; D006657:Histones / Q000235:genetics / Q000302:isolation & purification / Q000378:metabolism*; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D013090:Spermatocytes / Q000502:physiology; D013091:Spermatogenesis; D013737:Testis / Q000254:growth & development
D006657:Histones