Danazol binding to steroid receptors in human uterine endometrium.
To understand the mechanism of action of danazol, the binding of danazol to multiple classes of intracellular steroid binding proteins was studied in the human uterine endometrium. Danazol bound to endometrial receptors for estrogen, progesterone, and androgen and seemed to bind to endometrial intracellular corticosteroid-binding globulin and sex-hormone-binding globulin. Danazol occupies almost all binding sites of steroids in the steroid target cells in spite of the presence of endogenous steroids. It is speculated that the binding behavior of danazol may be related to its therapeutic effect on endometriosis.
D001665:Binding Sites; D003613:Danazol / Q000378:metabolism* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004717:Endometrium / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D011245:Pregnadienes / Q000378:metabolism*; D011944:Receptors, Androgen / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*
D011245:Pregnadienes; D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011987:Receptors, Steroid; D003613:Danazol