title: The in vitro effect of hypotensive agents on the affinity of haemoglobin for oxygen.
abstract: The effect of nitroglycerine, sodium nitroprusside, trimetaphan, pentolinium, labetalol and propranolol on the affinity of haemoglobin for oxygen was studied in vitro. Only pentolinium had a significant effect, increasing the binding of oxygen by haemoglobin. The significance of these results is discussed.
mesh_terms: D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007741:Labetalol / Q000494:pharmacology; D009599:Nitroprusside / Q000494:pharmacology; D010108:Oxyhemoglobins; D010425:Pentolinium Tartrate / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D014294:Trimethaphan / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology*
chemical_list: D010108:Oxyhemoglobins; D014665:Vasodilator Agents; D009599:Nitroprusside; D014294:Trimethaphan; D010425:Pentolinium Tartrate; D011433:Propranolol; D007741:Labetalol