[Role of lipolytic enzymes in the development of hyperlipidemia induced by administration of heterologous albumin in rabbits].
Experiments on rabbits have shown hyperlipidemia to develop within the first 48 h after a single intravenous injection of bovine serum albumin (BSA, fraction V). The mean concentration of blood plasma triglycerides (TG) was considerably higher than normal (by 262% after 24 and by 625% after 48 h). The cholesterol content was also elevated (by 80 and 270%, respectively). Following 7 and 14 days the lipid concentration returned to normal. The plasma post-heparin lipoprotein lipase activity (PHP-LPL) was lower 24 h and 7 days after BSA injection and the hypotriglyceridemic effect of heparin was less pronounced. The data obtained support the hypothesis that hyperlipidemia provoked by a single intravenous injection of BSA to rabbits results from low PHP-LPL activity and possible changes in TG-rich lipoprotein substrate affinity for the enzyme.
D000818:Animals; D005231:Fatty Acids, Unsaturated / Q000097:blood; D006949:Hyperlipidemias / Q000209:etiology*; D007136:Immunoglobulins / Q000096:biosynthesis; D007275:Injections, Intravenous; D008071:Lipoprotein Lipase / Q000097:blood*; D008297:Male; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000008:administration & dosage* / Q000276:immunology; D014280:Triglycerides / Q000097:blood
D005231:Fatty Acids, Unsaturated; D007136:Immunoglobulins; D014280:Triglycerides; D012710:Serum Albumin, Bovine; D008071:Lipoprotein Lipase
Uchastie lipoliticheskikh fermentov v razvitii giperlipidemii, vyzvannoĭ vvedeniem geterologichnogo al'bumina krolikam.