Early detection of myocardial infarction by an immunoradiometric procedure for creatine kinase MB.
I investigated the diagnostic efficacy of the Embria-CK immunoradiometric assay (IRMA) in detecting myocardial infarction, using a single blood sample drawn at hospital admission 0 to 10 h after the onset of chest pain and serial testing over a 24- to 48-h interval after hospital admission. The sensitivity, specificity, and efficiency for hospital admission samples were 87.5, 83.3, and 85.0%, respectively, and for serial testing, 100, 79.2, and 87.5%, respectively. The diagnostic efficacy was comparable to that of electrophoresis and significantly better than the Du Pont CK-MB method.
D002852:Chromatography, Ion Exchange; D003402:Creatine Kinase / Q000097:blood*; D004588:Electrophoresis, Cellulose Acetate; D006801:Humans; D007527:Isoenzymes; D009203:Myocardial Infarction / Q000175:diagnosis*; D011863:Radioimmunoassay; D013997:Time Factors
D007527:Isoenzymes; D003402:Creatine Kinase