Reversal of simian virus 40 small-t-antigen-induced theophylline resistance.
Simian virus 40 small-t antigen allows the growth of CV-1 cells in concentrations of theophylline that normally prevent cell cycling. This effect is completely overcome by two ionophores that uncouple mitochondria and by the anti-mitochondrial drug methylglyoxal bis-(guanylhydrazone).
D000957:Antigens, Viral, Tumor; D002453:Cell Cycle / Q000187:drug effects; D002478:Cells, Cultured; D004352:Drug Resistance, Microbial; D008928:Mitochondria / Q000502:physiology*; D011073:Polyamines / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D013806:Theophylline / Q000494:pharmacology*; D014475:Uncoupling Agents
D000957:Antigens, Viral, Tumor; D011073:Polyamines; D014475:Uncoupling Agents; D013806:Theophylline; D011188:Potassium