title: Oil and related toxicant effects on mallard immune defenses.
abstract: A crude oil, a petroleum distillate, and chemically dispersed oil were tested for their effects on resistance to bacterial infection and the immune response in waterfowl. Sublethal oral doses for mallards were determined for South Louisiana crude oil, Bunker C fuel oil, a dispersant--Corexit 9527, and oil/Corexit combinations by gizzard intubation. Resistance to bacterial challenge (Pasteurella multocida) was significantly lowered in mallards receiving 2.5 or 4.0 ml/kg of Bunker C fuel oil, 4.0 ml/kg of South Louisiana crude oil, and 4.0 ml/kg of a 50:1 Bunker C fuel oil/Corexit mixture daily for 28 days. Ingestion of oil or oil/Corexit mixtures had no effect on mallard antibody-producing capability as measured by the direct spleen plaque-forming assay.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation; D001522:Behavior, Animal / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004372:Ducks / Q000276:immunology*; D005648:Fuel Oils / Q000633:toxicity*; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010326:Pasteurella Infections / Q000276:immunology; D010578:Petroleum / Q000633:toxicity*; D013154:Spleen / Q000187:drug effects
chemical_list: D005648:Fuel Oils; D010578:Petroleum