Migration of blood-borne lymphocytes into antigen-stimulated lymph nodes. A study of the kinetics of lymphocyte recruitment throughout an immune response.
The kinetics of lymphocyte recruitment into rat popliteal lymph nodes stimulated with varying doses of allogeneic lymphocytes or purified protein derivative of tuberculin differed markedly. The number of blood-borne lymphocytes entering lymph nodes stimulated with allogeneic lymphocytes was greater and the duration of their entry more prolonged than in lymph nodes stimulated with the soluble antigen purified protein derivative of tuberculin. When individual antigenic doses were compared, lymphocyte recruitment into popliteal lymph nodes was shown to be dependent upon antigenic dose; higher doses of antigen resulting in increased levels of lymphocyte recruitment. In addition it was found that there is no linear relationship between lymph node weight changes and the extent of lymphocyte recruitment.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology*; D002465:Cell Movement; D007700:Kinetics; D007717:Knee; D008198:Lymph Nodes / Q000033:anatomy & histology / Q000276:immunology*; D008214:Lymphocytes / Q000166:cytology*; D008297:Male; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D014373:Tuberculin / Q000276:immunology
D000941:Antigens; D014373:Tuberculin