title: Nickel toxicity on carbohydrate metabolism of a freshwater fish, Colisa fasciatus.
abstract: Effects of sublethal concentration (0.8 of LC50 96 h) of nickel sulphate (NiSO4 X 7H2O) on muscle glycogen and blood lactic acid levels of a freshwater teleost, Colisa fasciatus, at time intervals from 3-96 h have been recorded. Muscle glycogen levels showed a general decrease at all time intervals compared with controls, with a maximum decrease of 35.2% at 96 h (P less than 0.001). Blood lactic acid showed an increase at all stages attaining a maximum of 78.12% at 12 h (P less than 0.001) except at 24 h where, for reasons not clearly understood, a distinct fall was recorded. The muscle glycogenolysis accompanied by blood hyperlacticaemia is probably the result of some direct action of nickel on the fish. The severe stress conditions caused by nickel-induced pathological changes in the gills and blood may also be responsible for these metabolic changes.
mesh_terms: D000818:Animals; D050260:Carbohydrate Metabolism; D005260:Female; D005399:Fishes / Q000378:metabolism*; D006003:Glycogen / Q000378:metabolism; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D009132:Muscles / Q000378:metabolism; D009532:Nickel / Q000633:toxicity*
chemical_list: D007773:Lactates; D019344:Lactic Acid; D009532:Nickel; D006003:Glycogen