Effects of gossypol on sperm counts in two inbred strains of mice.
Gossypol acetic acid was administered orally to mice of two inbred strains, BALB/c/O1a and CBA/Gr, at daily doses of 10 or 20 mg/kg for about 4 weeks. Treated mice of both strains showed a reduction in sperm counts. This was more marked in CBA mice, which also had smaller testes size than did BALB/c mice. The treatment had no significant effect on testicular weight but the caput epididymidis and seminal vesicles of treated mice weighed less than those of control mice.
D000818:Animals; D004822:Epididymis / Q000033:anatomy & histology / Q000187:drug effects; D006072:Gossypol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D009929:Organ Size / Q000187:drug effects; D012669:Seminal Vesicles / Q000033:anatomy & histology / Q000187:drug effects; D013076:Sperm Count; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000033:anatomy & histology / Q000187:drug effects
D006072:Gossypol; C028178:gossypol acetic acid