title: The human homologs of the raf (mil) oncogene are located on human chromosomes 3 and 4.
abstract: Two human genes that are homologous to both the murine transforming gene (oncogene) v-raf and the chicken transforming gene v-mil have been mapped by means of human-rodent somatic cell hybrids to human chromosomes previously devoid of known oncogenes. One gene, c-raf-2, which appears to be a processed pseudogene, is located on chromosome 4. The other gene, c-raf-1, which appears to be the active gene, is located on chromosome 3 and has been regionally mapped by chromosomal in situ hybridization to 3p25. This assignment correlates with specific chromosomal abnormalities associated with certain human malignancies.
mesh_terms: D000230:Adenocarcinoma / Q000235:genetics; D000818:Animals; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D002900:Chromosomes, Human, 1-3; D002905:Chromosomes, Human, 4-5; D006224:Cricetinae; D006801:Humans; D006822:Hybrid Cells; D007680:Kidney Neoplasms / Q000235:genetics; D008175:Lung Neoplasms / Q000235:genetics; D008297:Male; D051379:Mice; D009693:Nucleic Acid Hybridization; D009857:Oncogenes