Hepatocyte taurocholic acid uptake in the regression of ethinyl estradiol cholestasis. Preliminary results.
Taurocholic uptake in ethinyl estradiol cholestatic rats is significantly lower than in untreated rats. In the days following treatment withdrawal there is only a slow increase in uptake, which is still statistically lower than normal at the 11th day. Taurocholic acid uptake behaves in a different way from biliary flow and the amount of excreted bile acids. The diversity could be attributed to a different behaviour of bile acid carriers at the sinusoidal and biliary membranes in the hepatocyte or to a normalisation of bile acid carriers and Na+,K+,-ATPase activity at different times.
D000818:Animals; D002779:Cholestasis / Q000139:chemically induced* / Q000378:metabolism; D004997:Ethinyl Estradiol; D005260:Female; D008099:Liver / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D013656:Taurocholic Acid / Q000378:metabolism*
D004997:Ethinyl Estradiol; D013656:Taurocholic Acid