[Report on 8 years' experience in the prenatal diagnosis of genetic defects. III. Outcome of pregnancy].
The courses of 997 pregnancies out of 1113 prenatal diagnoses were analysed. The total rate of all fetal and neonatal losses is 11.6 per cent inclusively the therapeutically induced abortions. Peculiarities of our material are the shift to higher ages and the inclusion of pregnancies following amniofetography and fetoscopy. Without the last ones the perinatal mortality is 18.9 per thousand, the abortion rate is 2.6 per cent, the rate of premature deliveries (till the 37th gestational week) is 10.2 per cent and the rate of low birth weight babies below 2500 g is 6.1 per cent in connection with a frequency of caesarean sections of 9 per cent. 91 per cent of the newborns had Apgarscore of 8 to 10. The most favourable courses with an abortion rate of 2.2 per cent, a perinatal mortality of 11.8 per cent and a rate of low birth weight babies of 5.7 per cent are to be found following uncomplicated amniocentesis. Perinatal mortality is increased about the factor 10 combined with an threefold raise of prematurity in cases of brownish amniotic fluid. If the amniotic fluid was bloody and the repeated insertions during amniocentesis abortion rate is 10 per cent and perinatal mortality 44.4 per thousand. --3.2 per cent of pregnancies after fetoscopy are terminated by abortions. Perinatal mortality is 33.3 per thousand, the rate of low birth weight babies 26.7 per cent. Pregnancies following amniofetography have a most unfavourable course. The abortion rate is elevated to 11.2 per cent, perinatal mortality to 139.2 per thousand with a rate of low birth weight babies of 41.8 per cent. Following amniofetography every fourth newborn has a birth weight below 1500 grams.(ABSTRACT TRUNCATED AT 250 WORDS)
D000028:Abortion, Induced; D000022:Abortion, Spontaneous / Q000453:epidemiology; D000328:Adult; D000649:Amniocentesis; D002869:Chromosome Aberrations / Q000175:diagnosis*; D025063:Chromosome Disorders; D005260:Female; D005859:Germany, East; D006801:Humans; D007226:Infant Mortality; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008875:Middle Aged; D011247:Pregnancy; D011296:Prenatal Diagnosis
Erfahrungsbericht über 8 Jahre pränatale Diagnostik genetischer Defekte. III. Mitteilung: Schwangerschaftsausgang.