title: Cerebral organization of oral and signed language responses: case study evidence from amytal and cortical stimulation studies.
abstract: A normally hearing left-handed patient familiar with American Sign Language (ASL) was assessed under sodium amytal conditions and with left cortical stimulation in both oral speech and signed English. Lateralization was mixed but complementary in each language mode: the right hemisphere perfusion severely disrupted motoric aspects of both types of language expression, the left hemisphere perfusion specifically disrupted features of grammatical and semantic usage in each mode of expression. Both semantic and syntactic aspects of oral and signed responses were altered during left posterior temporal-parietal stimulation. Findings are discussed in terms of the neurological organization of ASL and linguistic organization in cases of early left hemisphere damage.
mesh_terms: D000328:Adult; D000654:Amobarbital / Q000494:pharmacology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D004292:Dominance, Cerebral / Q000502:physiology*; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D007802:Language; D008369:Manual Communication; D012660:Semantics; D012813:Sign Language; D013060:Speech / Q000502:physiology*
chemical_list: D000654:Amobarbital