Spectral analysis of kindled hippocampal afterdischarges in lead-treated rats.
Male rats were exposed to lead from parturition through weaning. When subjected to electrical hippocampal kindling as adults, although there were no alterations in the kindling rates, lead-treated animals were found to differ from controls in several other respects. In contrast to controls, lead-treated animals did not show an increase in afterdischarge (AD) duration with kindling, and the power spectrum of the AD did not shift to a higher peak frequency. There was a clear dose-related effect of lead on the spectra of the kindled AD, which in lead-treated groups was characterized by greater power in the low-frequency bands. These data indicate that long-lasting dysfunction can occur following a brief neonatal lead exposure. Power spectral techniques may be useful for future studies in neurotoxicology and epilepsy.
D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D004569:Electroencephalography / Q000379:methods; D006624:Hippocampus / Q000187:drug effects*; D007696:Kindling, Neurologic / Q000187:drug effects*; D007854:Lead / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats / Q000502:physiology*; D011919:Rats, Inbred Strains
D007854:Lead