[Compounds with potential gastric antisecretory and anti-ulcer activity. IV. Synthesis of 3- and 4-phenyl-2-oxo-5-[2-(methylpiperazine-1-yl)-acetyl]- 1H-2,3,4,5-tetrahydropyrido[2,3-b] [1,4]diazepine].
Pyrenzepinelike compounds, namely 2-oxo-3-phenyl- and 2-oxo-4-phenyl-5-[2-(4-methylpiperazin-1-yl)-acetyl]- 1H-2,3,4,5-tetrahydropyrido[2,3-b] [1,4]diazepine [(VIII) and (XIV) resp.] were synthetized. Both compounds were found to be inactive in rats against carbachol stimulated gastric secretion and cold + restraint induced ulcers.
D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis*; D001381:Azepines / Q000138:chemical synthesis* / Q000494:pharmacology; D002217:Carbachol / Q000037:antagonists & inhibitors; D055598:Chemical Phenomena; D002621:Chemistry; D003080:Cold Temperature; D005750:Gastric Juice / Q000378:metabolism; D051381:Rats; D012149:Restraint, Physical
D000897:Anti-Ulcer Agents; D001381:Azepines; D002217:Carbachol; C041168:3-phenyl-2-oxo-5-(2-(4-methylpiperazin-1-yl)acetyl)-1H-tetrahydropyrido(2,3b)(1,4)diazepine; C041171:4-phenyl-2-oxo-5-(2-(4-methylpiperazin-1-yl)acetyl)-1H-tetrahydropyrido(2,3-b)(1,4-)diazepine
Composti a potenziale attività antisecretiva gastrica e antiulcera. Nota IV. Sintesi della 3- e della 4-fenil-2-oxo-5-[2-(4-metilpiperazin-1-il)-acetil]- 1H-2,3,4,5-tetraidropirido[2,3-b] [1,4]diazepina.