[Peptic lesions of the upper digestive tract and drugs. Prospective study].
The association between drugs and diseases of the gastrointestinal tract is well known but has always been evaluated qualitatively and not quantitatively. To study the importance of this association, a prospective study was undertaken at the University of Geneva Hospital in 456 subjects. A statistically significant (p less than 0.05) correlation was found in the following associations: aspirin and multiple gastric ulcers, aspirin and severe erosive gastritis; non-steroidal antiinflammatory drugs and multiple duodenal ulcers, non-steroidal antiinflammatory drugs and mild erosive gastritis. On the other hand, no correlation was found between any of the observed gastrointestinal diseases and prednisone, alcohol or tobacco.
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D004942:Esophagitis, Peptic / Q000139:chemically induced*; D000431:Ethanol / Q000009:adverse effects; D005260:Female; D005756:Gastritis / Q000139:chemically induced*; D006801:Humans; D008297:Male; D010437:Peptic Ulcer / Q000139:chemically induced*; D011446:Prospective Studies; D012907:Smoking; D013557:Switzerland
D000893:Anti-Inflammatory Agents; D000431:Ethanol; D001241:Aspirin
Atteintes peptiques du tractus digestif supérieur et médicaments. Etude prospective.