title: Fragmented endocardial electrical activity in patients with ventricular tachycardia: a new guide to surgical therapy.
abstract: Eight patients with ventricular aneurysms and ventricular tachycardia refractory to drugs were studied. Each patient underwent intraoperative epicardial and endocardial mapping during stable sinus rhythm. After aneurysmectomy, areas of the endocardial border zone which demonstrated fragmented activity were excised. Mapping was then repeated to ensure that major areas of fragmentation did not remain. Mapping was completed in less than 20 minutes in each patient. One patient died of pump failure before hospital discharge and a second patient, who was arrhythmia-free, died of pump failure 12 months postoperatively. Six patients are alive and free of ventricular tachycardia 5 to 25 months (mean 11.5) postoperatively. We conclude that excision of areas of fragmented electrical activity in the endocardial border zone of ventricular aneurysms is a useful approach to surgical therapy for ventricular tachycardia. This approach allows an excision directed to arrhythmogenic areas without the need for tachycardia induction in the operating room.
mesh_terms: D000328:Adult; D000368:Aged; D006348:Cardiac Surgical Procedures; D004594:Electrophysiology; D004699:Endocardium / Q000473:pathology* / Q000601:surgery; D005260:Female; D006321:Heart / Q000503:physiopathology; D006322:Heart Aneurysm / Q000473:pathology* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D013610:Tachycardia / Q000503:physiopathology*