title: Hemoglobin solution--from tetramer to polymer.
abstract: Efforts to produce a clinically acceptable hemoglobin solution that could function as a temporary oxygen carrier have evolved through several stages. Beginning with the simple tetramer, we have lowered the affinity state by pyridoxylation and then polymerized the modified tetramer. This new substance, polyhemoglobin, has a normal oxygen capacity and a half-life of 38 hours. Issues of nephrotoxicity and immunocompetence after infusion remain to be defined.
mesh_terms: D000818:Animals; D001802:Blood Substitutes / Q000009:adverse effects; D055598:Chemical Phenomena; D002621:Chemistry; D005078:Exchange Transfusion, Whole Blood; D006400:Hematocrit; D006454:Hemoglobins / Q000009:adverse effects / Q000032:analysis; D006801:Humans; D007121:Immunocompetence; D007674:Kidney Diseases / Q000209:etiology; D008297:Male; D009997:Osmotic Pressure; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D010215:Papio; D010313:Partial Pressure; D051381:Rats
chemical_list: D001802:Blood Substitutes; D006454:Hemoglobins; C037158:polyhemoglobin; D010100:Oxygen