title: Stereoselective inhibition of synaptosomal catecholamine uptake by nomifensine.
abstract: The effects of the two enantiomers of the antidepressant nomifensine on catecholamine uptake were investigated using rat brain synaptosomes. According to the results from in vitro and ex vivo/in vitro studies, the inhibitory activity on catecholamine uptake resides entirely in the (+)-form of nomifensine. Further studies comparing the antidepressant effects of the two enantiomers might help to clarify the validity of the catecholamine hypothesis of depression.
mesh_terms: D000042:Absorption; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002395:Catecholamines / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D007546:Isoquinolines / Q000494:pharmacology*; D009627:Nomifensine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013574:Synaptosomes / Q000378:metabolism*
chemical_list: D002395:Catecholamines; D007546:Isoquinolines; D009627:Nomifensine