The mode of carcinogenic action of saccharin.
It is suggested that the induction of bladder cancer in male rats by saccharin is related to the integrity of the urothelial permeability barrier and that, in the Sprague-Dawley rat, saccharin is unable to attain a sufficient concentration in the urothelium if the barrier remains intact. The effect of saccharin, once it enters the urothelium, may be mediated by its ability to inhibit certain enzymes or by other mechanisms. The importance of the permeability barrier concept is explored as a means of identifying a human subpopulation possibly at an increased risk of saccharin-induced bladder cancer.
D000818:Animals; D002273:Carcinogens; D002463:Cell Membrane Permeability / Q000187:drug effects; D004198:Disease Susceptibility; D004848:Epithelium / Q000378:metabolism; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012306:Risk; D012439:Saccharin / Q000378:metabolism* / Q000633:toxicity; D012737:Sex Factors; D001743:Urinary Bladder / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D012439:Saccharin