Regulation of 2',5'-oligo(A) synthetase activity in theophylline-treated NIH 3T3 cells.
Sequential treatment of NIH 3T3 cells with theophylline and actinomycin D results in an enhancement of 2',5'-oligo(A) synthetase activity 2-3-fold exceeding that induced by treatment with theophylline only. This 'superinduction' phenomenon suggests the existence of a negative control of the enzyme that involves a labile, transcription-dependent factor.
D015088:2',5'-Oligoadenylate Synthetase / Q000235:genetics / Q000378:metabolism*; D000818:Animals; D002460:Cell Line; D003609:Dactinomycin / Q000494:pharmacology; D051379:Mice; D013806:Theophylline / Q000494:pharmacology*; D014158:Transcription, Genetic / Q000187:drug effects
D003609:Dactinomycin; D013806:Theophylline; D015088:2',5'-Oligoadenylate Synthetase