The in vitro effect of hypotensive agents on the affinity of haemoglobin for oxygen.
The effect of nitroglycerine, sodium nitroprusside, trimetaphan, pentolinium, labetalol and propranolol on the affinity of haemoglobin for oxygen was studied in vitro. Only pentolinium had a significant effect, increasing the binding of oxygen by haemoglobin. The significance of these results is discussed.
D004912:Erythrocytes / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D007741:Labetalol / Q000494:pharmacology; D009599:Nitroprusside / Q000494:pharmacology; D010108:Oxyhemoglobins; D010425:Pentolinium Tartrate / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D014294:Trimethaphan / Q000494:pharmacology; D014665:Vasodilator Agents / Q000494:pharmacology*
D010108:Oxyhemoglobins; D014665:Vasodilator Agents; D009599:Nitroprusside; D014294:Trimethaphan; D010425:Pentolinium Tartrate; D011433:Propranolol; D007741:Labetalol