The effect of altered thyroid status on lipid metabolism in Nubian goats.
The effects of triiodothyronine (T3)-induced hyperthyroidism and of carbimazole (CZ)-produced hypothyroidism on lipid metabolism were studied in Nubian goats (Capra hircus). T3 treatment decreased the serum, liver and heart triglyceride, cholesterol and phospholipid concentrations. These changes were accompanied by an increase in the activity of lipoprotein lipase (LPL) in the heart and skeletal muscles. CZ treatment at a dose of 90 mg/goat significantly increased the serum triglyceride, liver cholesterol and heart phospholipid. CZ treatment significantly increased the liver and heart triglyceride concentration but the activity of LPL was not affected.
D000818:Animals; D002231:Carbimazole / Q000494:pharmacology; D002784:Cholesterol / Q000378:metabolism; D008076:Cholesterol, HDL; D005227:Fatty Acids / Q000378:metabolism; D006041:Goats / Q000378:metabolism*; D006980:Hyperthyroidism / Q000378:metabolism / Q000662:veterinary; D007037:Hypothyroidism / Q000378:metabolism / Q000662:veterinary; D050356:Lipid Metabolism; D008071:Lipoprotein Lipase / Q000378:metabolism; D008075:Lipoproteins, HDL / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D008297:Male; D009206:Myocardium / Q000201:enzymology; D013961:Thyroid Gland / Q000502:physiology*; D014284:Triiodothyronine / Q000494:pharmacology
D008076:Cholesterol, HDL; D005227:Fatty Acids; D008075:Lipoproteins, HDL; D014284:Triiodothyronine; D002231:Carbimazole; D002784:Cholesterol; D008071:Lipoprotein Lipase