Inherited AT-III deficiency: fast and slow inactivation of thrombin and factor Xa.
A family with inherited AT-III deficiency is presented. This variant is unlike those formerly described, as the plasma concentration is high, the thrombin inhibition with heparin is slow, and factor Xa inhibition is decreased.
D020152:Antithrombin III Deficiency; D005170:Factor X / Q000037:antagonists & inhibitors*; D015951:Factor Xa; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D013917:Thrombin / Q000037:antagonists & inhibitors*; D013924:Thrombophlebitis / Q000235:genetics
D005170:Factor X; D006493:Heparin; D013917:Thrombin; D015951:Factor Xa