Hemodynamic effects of diuretic therapy in hypertension.
The antihypertensive effect of diuretics is well documented. At least some preserved kidney function seems to be necessary to achieve a demonstrable effect. The importance of fluid volume reduction for the antihypertensive effect of these drugs during long-term treatment is however uncertain. The effects on central hemodynamics vary according to the literature, but the blood pressure reduction in responders (delta MAP greater than 10%) may primarily be explained by a reduction of the total peripheral vascular resistance. The peripheral circulation is influenced in the same way. Sometimes a flow reduction is observed, and sometimes a resistance reduction. In spite of a lasting blood pressure reduction after treatment with diuretics, the structural hypertensive vascular changes do not seem to be influenced.
D001826:Body Fluids / Q000187:drug effects; D004232:Diuretics / Q000627:therapeutic use*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007668:Kidney / Q000503:physiopathology; D012079:Renal Circulation / Q000187:drug effects; D012084:Renin-Angiotensin System / Q000187:drug effects
D004232:Diuretics