title: [Renewal of mitochondrial DNA in the liver of rats of different ages].
abstract: The rate of mitochondrial DNA turnover was studied in the liver of adult and old rats. It was shown to decrease with aging in both the whole mitochondrial population and its heavy and light fractions. This decrease reflects the deceleration of the rate of liver mitochondrial biogenesis in old age and is considered to be a cause of energy deficiency of an old body.
mesh_terms: D000375:Aging; D000818:Animals; D004272:DNA, Mitochondrial / Q000096:biosynthesis*; D005260:Female; D008930:Mitochondria, Liver / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D004272:DNA, Mitochondrial
vernacular_title: Obnovlenie mitokhondrial'noĭ DNK v pecheni krys raznogo vozrasta.