[Somatotropin-synthesizing activity of the in vitro cultured adenohypophyses of intact, hypo- and hyperthyroid rats].
Somatotropin-synthetizing activity of the adenohypophyses cultivated in vitro in eu-, hupo- and hyperthyroid rats was investigated. The most pronounced persistence of the activity (89%) within 12 days is seen in the adenohypophyses of hypothyroid rats and less evident (41%) in the adenohypophyses of hyperthyroid animals in comparison with that of euthyroid rats (66%). The activity rise in the adenohypophyses of euthyroid hypothyroid rats is observed by the 6th day of cultivation, being more pronounced in the adenohypophyses of hypo- than euthyroid animals. The adenohypophyses cultivated in vitro in hypo- and hyperthyroid rats may serve as models for studying the adenohypophyseal somatotropic function disorders in hypo- and hyperthyroses.
D000818:Animals; D013006:Growth Hormone / Q000096:biosynthesis*; D006980:Hyperthyroidism / Q000378:metabolism*; D007037:Hypothyroidism / Q000378:metabolism*; D008297:Male; D009924:Organ Culture Techniques; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013965:Thyroidectomy; D013974:Thyroxine / Q000494:pharmacology; D013997:Time Factors
D013006:Growth Hormone; D013974:Thyroxine
Somatotropinsinteziruiushchaia aktivnost' kul'tiviruemykh vne organizma adenogipofizov intaktnykh, gipo- i gipertireoidnykh krys.