[Effect of ethanol on the synthesis of chromatin proteins of the nuclei of rat liver cells].
The synthesis of nuclear chromatin proteins of rat liver cells was studied after a momentary and chronic administration of ethanol (3 g/kg). The 14C-acetaldehyde penetration to the nuclei and its binding to chromatin protein components were also studied. The momentary administration of ethanol inhibits the synthesis of histons and reenhances the incorporation of radioactive precursors into DNA labile-bound nonhiston proteins. The reduced level of the synthesis of all the studied chromatin proteins was observed after the chronic administration of ethanol.
D000079:Acetaldehyde / Q000378:metabolism; D000818:Animals; D002843:Chromatin / Q000096:biosynthesis* / Q000378:metabolism; D002868:Chromosomal Proteins, Non-Histone / Q000096:biosynthesis; D004247:DNA / Q000378:metabolism; D003864:Depression, Chemical; D000431:Ethanol / Q000494:pharmacology*; D006657:Histones / Q000096:biosynthesis; D008099:Liver / Q000378:metabolism*; D008297:Male; D011485:Protein Binding; D051381:Rats
D002843:Chromatin; D002868:Chromosomal Proteins, Non-Histone; D006657:Histones; D000431:Ethanol; D004247:DNA; D000079:Acetaldehyde
Vliianie étanola na sintez khromatinovykh belkov iader kletok pecheni krys.