Time course of the changes in uterine vascular permeability associated with the development of the decidual cell reaction in ovariectomized steroid-treated rats.
Uterine vascular permeability and tissue blood volume during the development of the oil-induced decidual cell reaction (DCR) in ovariectomized steroid-treated rats were assessed by measuring the extravascular accumulation of 125I-labelled human serum albumin and the tissue content of 51Cr-labelled red cells 30 min after intravenous administration. Within 15 min of oil instillation into one uterine horn, the vascular permeability of the horn was significantly elevated. Permeability rose to a sharp peak (10 times control levels) 9 h after oil instillation, but dropped to 5 times control values by 12 h and continued a steady decline over the next 7 days. Although a marked increase in uterine weight was associated with the development of the DCR, there was no significant change in blood volume/g tissue until 4 days after oil instillation.
D000818:Animals; D001810:Blood Volume / Q000187:drug effects; D002199:Capillary Permeability / Q000187:drug effects; D002369:Castration; D003656:Decidua / Q000187:drug effects / Q000502:physiology*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D009821:Oils / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D000074241:Peanut Oil; D010938:Plant Oils; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000378:metabolism; D013997:Time Factors; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D009821:Oils; D000074241:Peanut Oil; D010938:Plant Oils; D012709:Serum Albumin; D011374:Progesterone; D004958:Estradiol