Formation of adrenochrome by bovine cardiac sarcolemma.
A sarcolemma preparation from bovine heart was able to promote adrenaline oxidation especially when NADH and NADPH were added. The superoxide anion O(2) was demonstrated to be involved in the activation of adrenochrome production.
D000323:Adrenochrome / Q000096:biosynthesis*; D000818:Animals; D002417:Cattle; D004837:Epinephrine / Q000378:metabolism; D066298:In Vitro Techniques; D009206:Myocardium / Q000378:metabolism*; D009243:NAD / Q000494:pharmacology; D009249:NADP / Q000494:pharmacology; D010084:Oxidation-Reduction / Q000187:drug effects; D012508:Sarcolemma / Q000378:metabolism*
D009243:NAD; D009249:NADP; D000323:Adrenochrome; D004837:Epinephrine