Case report of a toxic reaction from a combination of tryptophan and phenelzine.
The addition of tryptophan to a monoamine oxidase inhibitor (MAOI) has been recommended for patients failing to respond to an MAOI alone. The authors report acute behavioral and neurologic toxicity immediately after tryptophan administration in a patient taking phenelzine.
D000328:Adult; D001714:Bipolar Disorder / Q000139:chemically induced*; D003866:Depressive Disorder / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D009069:Movement Disorders / Q000139:chemically induced*; D010624:Phenelzine / Q000008:administration & dosage* / Q000009:adverse effects; D014364:Tryptophan / Q000008:administration & dosage / Q000009:adverse effects*
D014364:Tryptophan; D010624:Phenelzine