Reduced cholecystokinin immunoreactivity in the cerebrospinal fluid of patients with psychiatric disorders.
The close relationship of cholecystokinin peptides with some of the dopamine pathways and the limbic system suggests a putative role for these peptides in the pathophysiology of neuropsychiatric disorders such as Parkinson's disease, manic-depression and schizophrenia. By use of radioimmunoassay, we report a significant decrease in cholecystokinin-immunoreactivity in the cerebrospinal fluid of patients with bipolar manic-depression and untreated schizophrenia in comparison to control subjects.
D000328:Adult; D001714:Bipolar Disorder / Q000134:cerebrospinal fluid; D002766:Cholecystokinin / Q000134:cerebrospinal fluid* / Q000276:immunology; D003866:Depressive Disorder / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000134:cerebrospinal fluid*; D008875:Middle Aged; D010300:Parkinson Disease / Q000134:cerebrospinal fluid; D012559:Schizophrenia / Q000134:cerebrospinal fluid
D002766:Cholecystokinin