Axonal microtubules necessary for generation of sodium current in squid giant axons: II. Effect of colchicine upon asymmetrical displacement current.
Effect of internal colchicine on asymmetrical displacement currents was studied by internally perfusing squid giant axons with a solution containing colchicine. It was found that (1) asymmetrical displacement currents were composed of two parts; colchicine-sensitive and colchicine-resistant; that (2) the colchicine-sensitive part had a definite rising phase while the colchicine-resistant one showed an instantaneous jump, followed by exponential decay; and that (3) the colchicine-sensitive part related to normal Na channels.
D000818:Animals; D001369:Axons / Q000187:drug effects* / Q000502:physiology; D003078:Colchicine / Q000494:pharmacology*; D049832:Decapodiformes; D008870:Microtubules / Q000187:drug effects / Q000502:physiology; D011034:Podophyllotoxin / Q000494:pharmacology; D012964:Sodium / Q000378:metabolism*; D014747:Vinblastine / Q000494:pharmacology
D014747:Vinblastine; D012964:Sodium; D011034:Podophyllotoxin; D003078:Colchicine