The lethal syndrome following intravenous injection of Ehrlich ascites tumour cells in cycloheximide-treated mice and its prevention by heparin.
Heparin was shown to be a life-saving treatment in the otherwise lethal syndrome following intravenous injection of Ehrlich ascites tumour cells in cycloheximide-treated mice, and in mice treated with cycloheximide 2 h after injection of Ehrlich tumour cells. The effectiveness of heparin cannot be attributed to interference with initial arrest of tumour cells. A similar lethal syndrome, again prevented by heparin treatment, occurs in mice given intravenous colloidal carbon and cycloheximide. It is suggested that large doses of intravenous particulates bring about changes in plasma composition which are rapidly rectified in an otherwise normal mouse, but which persist under the influence of cycloheximide and lead to the irreversible and fatal outcome. Finally, evidence is presented which suggests that liver protein synthesis may play an essential role in the period following intravenous injection of tumour cells in an otherwise normal mouse.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D003513:Cycloheximide / Q000633:toxicity*; D006493:Heparin / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D014176:Protein Biosynthesis; D013577:Syndrome
D006493:Heparin; D003513:Cycloheximide