[Effect of combined exposure to an interferon inducer, irradiation and 5-fluorouracil on sarcoma 37 in mice].
Oral administration of a liposome-encapsulated agent triggering the synthesis of interferon--poly(I) poly (C)--to mice bearing solid sarcoma 37 was followed by (a) production of an interferon which circulates for a longer period after preliminary administration of "empty" liposomes; (b) lengthening of the period of tumor latency; in some cases tumor failed to appear at all; (c) higher efficacy of radiation treatment which was manifested by a higher inhibition of tumor growth or complete regression; (d) increased antitumor effect of 5-fluorouracil, and (e) suppression of proliferative activity of tumor.
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects / Q000528:radiation effects; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage*; D007369:Interferon Inducers / Q000008:administration & dosage*; D008081:Liposomes / Q000008:administration & dosage; D051379:Mice; D009368:Neoplasm Transplantation; D011070:Poly I-C / Q000008:administration & dosage; D011879:Radiotherapy Dosage; D012511:Sarcoma 37 / Q000401:mortality / Q000628:therapy*; D012513:Sarcoma, Experimental / Q000628:therapy*; D013997:Time Factors
D007369:Interferon Inducers; D008081:Liposomes; D011070:Poly I-C; D005472:Fluorouracil
Effekt kombinirovannogo vozdeĭstviia induktora interferona, oblucheniia i 5-ftoruratsila na sarkomu 37 mysheĭ.