title: Molecular species of phospholipid in rat hepatomas and in fetal, regenerating, and adult rat livers.
abstract: The molecular species of phospholipid in rat hepatomas were found to be different from those in normal adult liver. Phosphatidylcholine in Yoshida hepatoma contained phosphatidylcholine with 34:1 as the sums of the chain length and of the unsaturation of fatty acids esterified at C-1 and C-2 of glycerol, as an example (PC34:1), PC36:2, PC36:1, PC34:2, and PC36:3, and its phosphatidylethanolamine contained PE36:2, PE36:1, PE38:4, PE36:3, and PE34:1 as major species, whereas phosphatidylcholine in normal adult liver contained PC38:4, PC36:2, PC34:2, PC36:4, and PC34:1, and its phosphatidylethanolamine (PE) contained PE38:4, PE38:6, PE40:6, PE36:4, and PE36:2, with their level decreasing in that order. While Morris hepatoma also had significantly lower amounts of species containing polyunsaturated fatty acids, there were higher levels of those phosphoglycerides containing monoenoic and dienoic fatty acids. Regenerating liver showed similar patterns of molecular species of both phospholipids to those of normal liver. In contrast, fetal liver had similar molecular species of phosphatidycholine to those of hepatomas, but had similar species of phosphatidylethanolamine to those of normal and regenerating livers.
mesh_terms: D000818:Animals; D005227:Fatty Acids / Q000032:analysis; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D008099:Liver / Q000032:analysis* / Q000196:embryology; D008114:Liver Neoplasms, Experimental / Q000032:analysis*; D008115:Liver Regeneration; D010743:Phospholipids / Q000302:isolation & purification*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005227:Fatty Acids; D010743:Phospholipids