Interaction between frusemide and aspirin.
The effects of the combination of aspirin and frusemide were studied on salicylate excretion by aspirin and on the diuresis and excretion of K+ and Na+ by frusemide in normal human subjects. There was a paradoxical net reduction in the natriuresis induced by aspirin, from 29.4 +/- 3.57 m-equiv and frusemide from 31.9 +/- 1.27 to 23.7 +/- 1.56 m-equiv on combined administration. Frusemide caused a reduction of the kalliuretic effect induced by aspirin from 48.86 +/- 8.36 to 18.3 +/- 3.76 m-equiv. The amount of salicylate excreted over a 3-hr period gave increases of 9.6 and 12.0% when aspirin was administered before frusemide and vice versa, respectively, while there was a 30.4% reduction when administered concomitantly.
D000328:Adult; D001241:Aspirin / Q000378:metabolism / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D005260:Female; D005665:Furosemide / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D011188:Potassium / Q000378:metabolism; D012459:Salicylates / Q000652:urine; D020156:Salicylic Acid
D012459:Salicylates; D005665:Furosemide; D020156:Salicylic Acid; D001241:Aspirin; D011188:Potassium