The pathogenesis of amiodarone-induced pigmentation and photosensitivity.
A new method has been used to measure tissue levels of amiodarone and its major metabolite desethylamiodarone. Amiodarone-pigmented skin has a drug and metabolite concentration ten times that of non-pigmented skin. Iodine-rich amiodarone and its metabolite have been detected in secondary lysosomes by energy dispersive analysis of X-rays. Amiodarone induces a phototoxic reaction with an action spectrum in both the UV-B and UV-A wavelengths.
D000328:Adult; D000638:Amiodarone / Q000009:adverse effects* / Q000031:analogs & derivatives / Q000378:metabolism; D001572:Benzofurans / Q000009:adverse effects*; D002851:Chromatography, High Pressure Liquid; D004577:Electron Probe Microanalysis; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D012867:Skin / Q000378:metabolism / Q000473:pathology; D012880:Skin Pigmentation
D001572:Benzofurans; C036116:desethylamiodarone; D000638:Amiodarone