title: The prevalence of thyroid disorders in a middle-aged female population, with special reference to the solitary thyroid nodule.
abstract: A survey of thyroid disease was conducted in 477 middle-aged women selected at random in an urban area where goiter is not endemic. The overall occurrence of thyroid disease was estimated to be 16.2%. Previously known disease was reported by 6.7% of those surveyed, and an additional 9.5% were diagnosed in the present study. The prevalence of all goiter was 11.3%, and of a palpable solitary nodule, 6.5%. Women with goiter were examined by thyroid scintigraphy and fine-needle aspiration cytology. The results of these examinations combined with the conventional clinical examination were considered a sufficient basis for benign diagnosis in all cases except one, a woman with a solitary nodule who was surgically treated because the cytologic report indicated follicular neoplasm; histopathology, however, revealed colloid goiter. The accumulated incidence of hyperthyroidism was 2.3% and of hypothyroidism 0.8%. It is concluded that goiter is a common disorder among women living in non-endemic areas, and that most goiter, including palpable solitary nodules, can be classified after evaluation as multinodular goiter.
mesh_terms: D000367:Age Factors; D001707:Biopsy, Needle; D005260:Female; D006042:Goiter / Q000453:epidemiology*; D006801:Humans; D006980:Hyperthyroidism / Q000453:epidemiology*; D008875:Middle Aged; D010173:Palpation; D011877:Radionuclide Imaging; D012737:Sex Factors; D013548:Sweden; D013961:Thyroid Gland / Q000000981:diagnostic imaging / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000453:epidemiology*; D013966:Thyroiditis / Q000453:epidemiology*; D014505:Urban Population