title: Serum thyroglobulin determinations in the differential diagnosis of congenital hypothyroidism.
abstract: The value of serum thyroglobulin (Tg) determination in the differential diagnosis of congenital hypothyroidism was assessed by serum Tg measurements in 14 patients with proven congenital hypothyroidism, in 3 subjects with transient perinatal hypothyroidism, in 3 newborns with congenital thyroxine binding globulin (TBG) deficiency and in 34 normal controls. Serum Tg was undetectable in all 6 cases with thyroid agenesis, normal or moderately elevated in the 4 cases with ectopic thyroid, markedly increased in the 4 cases with dyshormonogenic goiter and normal in the 3 cases with transient hypothyroidism and in the 3 with TBG deficiency. The present data indicate that serum Tg measurements may be useful in the differentiation of athyreotic hypothyroidism from other conditions of congenital hypothyroidism.
mesh_terms: D000293:Adolescent; D002648:Child; D003409:Congenital Hypothyroidism; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000175:diagnosis; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D013954:Thyroglobulin / Q000097:blood*
chemical_list: D013954:Thyroglobulin