title: The absolute bioavailability of oral cefuroxime axetil in male and female volunteers after fasting and after food.
abstract: Cefuroxime axetil is a novel oral cephalosporin. Two studies are described in which fasting male and female volunteers were given single oral doses of 1 g cefuroxime axetil in comparison with intravenous cefuroxime, and in which absorption was compared in the fasting and non-fasting states. The mean (and range) absolute bioavailability of cefuroxime axetil in the first study was 0.35 (0.26-0.44) in male volunteers and 0.32 (0.23-0.41) in female volunteers. In the second study, the bioavailability was significantly greater when cefuroxime axetil was given after food: 0.45 (0.34-0.55) in males and 0.41 (0.29-0.51) in females. There were no differences between the pharmacokinetics of cefuroxime axetil in males and females. It is recommended that patients take doses of cefuroxime axetil shortly after food.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002444:Cefuroxime / Q000008:administration & dosage / Q000378:metabolism*; D002511:Cephalosporins / Q000378:metabolism*; D005215:Fasting; D005260:Female; D005502:Food; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D011897:Random Allocation; D012737:Sex Factors
chemical_list: D002511:Cephalosporins; D002444:Cefuroxime