Characterization of idiotypes on antibodies to galactan.
The correlation between the primary structure and the expression of idiotypy in the anti-galactan antibody system is extremely precise. Amino-acid residues, which are implicated in the expression of recurrent or private idiotopes, are localized in the CDR3 region of all hybridomas and of at least 2 out of 4 myeloma proteins. A single substitution in this region may, in some cases, suffice to abolish idiotope expression.
D000595:Amino Acid Sequence; D000818:Animals; D005685:Galactans / Q000276:immunology* / Q000378:metabolism; D006825:Hybridomas / Q000032:analysis; D007130:Immunoglobulin Idiotypes / Q000032:analysis*; D051379:Mice; D008807:Mice, Inbred BALB C; D009194:Myeloma Proteins / Q000378:metabolism
D005685:Galactans; D007130:Immunoglobulin Idiotypes; D009194:Myeloma Proteins