Distal tubular dysfunction in rats chronically exposed to a 'white spirit' solvent.
Inhalation exposure of male Sprague-Dawley rats to an industrial white-spirit solvent composed of a C10-C12 mixture of branched-chain unsubstituted satured aliphatic hydrocarbons at 6500 mg/m3 for over 9 months resulted in decreased urinary concentrating ability, decreased net acid excretion following a mild ammonium chloride load and increased urinary lactate dehydrogenase (LDH) activity, whereas urinary beta-N-acetyl-D-glycosaminidase (NAG) activity remained normal. These observations suggest the existence of distal tubular alteration in the rat kidney.
D000118:Acetylglucosaminidase / Q000652:urine; D000818:Animals; D006838:Hydrocarbons / Q000633:toxicity*; D007671:Kidney Concentrating Ability / Q000187:drug effects; D007674:Kidney Diseases / Q000139:chemically induced / Q000652:urine; D007684:Kidney Tubules / Q000187:drug effects*; D007686:Kidney Tubules, Distal / Q000187:drug effects*; D007770:L-Lactate Dehydrogenase / Q000652:urine; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012997:Solvents / Q000633:toxicity*
D006838:Hydrocarbons; D012997:Solvents; C013089:ligroin; D007770:L-Lactate Dehydrogenase; D000118:Acetylglucosaminidase