Changes of hexachlorobutadiene nephrotoxicity after piperonyl butoxide treatment.
The effects of piperonyl butoxide on hexachlorobutadiene (HCBD) nephrotoxicity were measured. The time course and severity of toxicity were affected. Five hours after either piperonyl butoxide or HCBD glomerular filtration rate (GFR) was decreased; at 24 h GFR had recovered for the piperonyl butoxide group but continued to fall in the HCBD group. The group treated with piperonyl butoxide and HCBD had the same GFR as the group treated with just HCBD. At 24 h after HCBD the piperonyl butoxide pretreated group was not different from the oil pretreated controls. At 48 h after HCBD, reabsorbtion of water and glucose was more severely impaired in the group pretreated with piperonyl butoxide. These results support the hypothesis that HCBD metabolites are involved in renal tubular dysfunction.
D000818:Animals; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D002070:Butadienes / Q000378:metabolism / Q000633:toxicity*; D003404:Creatinine / Q000097:blood; D004347:Drug Interactions; D005919:Glomerular Filtration Rate / Q000187:drug effects; D007668:Kidney / Q000098:blood supply; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism; D008297:Male; D010882:Piperonyl Butoxide / Q000378:metabolism / Q000494:pharmacology*; D011188:Potassium / Q000652:urine; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000652:urine
D002070:Butadienes; D012964:Sodium; D003404:Creatinine; C001335:hexachlorobutadiene; D010882:Piperonyl Butoxide; D011188:Potassium