Non-parenteral postoperative analgesia. A comparison of sublingual buprenorphine and morphine sulphate (slow release) tablets.
Sixty-nine patients undergoing upper and lower abdominal surgery were studied after operation to compare the analgesic effects of sublingual buprenorphine (0.4 mg) and slow release morphine sulphate tablets (MST, 20 mg) given 6 hourly in a double-blind, double-dummy trial. Both MST and buprenorphine produced satisfactory postoperative analgesia but the linear analogue pain scores were significantly lower on the second post operative day with MST.
D000005:Abdomen / Q000601:surgery; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D002047:Buprenorphine / Q000008:administration & dosage* / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D009019:Morphinans / Q000008:administration & dosage*; D009020:Morphine / Q000008:administration & dosage* / Q000627:therapeutic use; D010149:Postoperative Pain / Q000188:drug therapy*
D003692:Delayed-Action Preparations; D009019:Morphinans; D002047:Buprenorphine; D009020:Morphine