Haemolytic activity of aromatic heptaenes. A group of polyene macrolide antifungal antibiotics.
The aromatic heptaene vacidin A induces ion selective channels in human red blood cells. The ion flux induced leads to a secondary effect--colloid osmotic haemolysis. Molecular variations at ionizable polar groups of the antibiotic modify the properties of the permeability pathway concerning intercationic selectivity and the symmetry of ion flux.
D000935:Antifungal Agents / Q000494:pharmacology*; D002174:Candicidin / Q000031:analogs & derivatives / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000187:drug effects; D006461:Hemolysis; D006801:Humans; D009995:Osmosis / Q000187:drug effects; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D013997:Time Factors
D000935:Antifungal Agents; D002174:Candicidin; C031985:vacidin A; D012964:Sodium; D011188:Potassium