Primary squamous cell carcinoma of anterior male urethra.
Primary squamous cell carcinoma of the anterior male urethra, which accounts for most carcinomas in that site, is a rare lesion. Ten cases having occurred in the last ten years were divided into distal and proximal anterior urethral lesions. Analysis of these cases confirms the need for a high index of suspicion for the lesion in patients who have chronic stricture disease; surgical treatment as the primary therapeutic modality; the fact that distal lesions generally have a better prognosis than proximal lesions, thus may sometimes be treated more conservatively; and the fact that adenopathy (especially of the pelvic nodes) usually heralds a poorer prognosis. Retrograde urethrography, endoscopy with biopsy, and bimanual examination are all essential for proper diagnosis, staging, and management.
D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008197:Lymph Node Excision; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010388:Pelvis; D011379:Prognosis; D011468:Prostatectomy; D014521:Urethra / Q000601:surgery; D014523:Urethral Neoplasms / Q000175:diagnosis / Q000401:mortality / Q000601:surgery*