title: [Effect of the biotransformation of the insecticide furadan on in vivo and in vitro manifestations of its cytogenetic activity].
abstract: Investigation of a cytogenetic activity of the insecticide carbofuran and its three main metabolites formed in the mammals' organisms and in the environmental objects showed that the initial substance and two intermediate products of its biotransformation (3-hydroxycarbofuran and 3-keto-carbofuran) induced a clastogenic effect in the culture of human peripheral lymphocytes in vitro. The end metabolite (3-keto-7-phenol) had no mutagenic effect in vitro. The data obtained give evidence for disappearance of the carbofuran mutagenicity in the course of its biotransformation in mammals.
mesh_terms: D000328:Adult; D000818:Animals; D001388:Aziridines / Q000494:pharmacology; D001711:Biotransformation; D001853:Bone Marrow / Q000187:drug effects; D002235:Carbofuran / Q000378:metabolism* / Q000494:pharmacology; D002629:Chemosterilants / Q000494:pharmacology; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007306:Insecticides / Q000378:metabolism*; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D009153:Mutagens / Q000378:metabolism* / Q000494:pharmacology; D010944:Plants / Q000378:metabolism
chemical_list: D001388:Aziridines; D002629:Chemosterilants; D007306:Insecticides; D009153:Mutagens; C026085:dimatiph; D002235:Carbofuran
vernacular_title: Vliianie biotransformatsii insektitsida furadana na proiavlenie ego tsitogeneticheskoĭ aktivnosti in vivo i in vitro.