[Isolation and study of the antibiotics produced by a culture of Str. iverini (Gause et al., 1957) Pridham et al., 1958].
An antibiotic complex consisting of echinomycin and triostin A was isolated from Str. iverini (Gauze et al., 1957) Pridham et al., 1958. Hydrolysis of the antibiotics resulted in formation of an aglycone identified with quinoxaline carboxylic acid. The UV spectrum of the aglycone and the antibiotics of the echinomycin-triostin group was studied.
D000596:Amino Acids / Q000032:analysis; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000032:analysis / Q000302:isolation & purification* / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D007942:Leukemia, Experimental / Q000188:drug therapy; D008223:Lymphoma / Q000188:drug therapy; D013058:Mass Spectrometry; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D009368:Neoplasm Transplantation; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013302:Streptomyces / Q000145:classification / Q000378:metabolism*
D000596:Amino Acids; D000903:Antibiotics, Antineoplastic
Vydelenie i izuchenie antibiotikov, produtsiruemykh kul'turoĭ Str. iverini (Gause et al., 1957) Pridham et al., 1958.