Is nisoldipine capable of reducing left ventricular preload?
In ten anesthetized pigs, nisoldipine (2-4 micrograms X kg-1 X min-1), a calcium channel blocker structurally related to nifedipine, reduced left ventricular systolic pressure (40%) and systemic vascular resistance (35%), whereas maxLVdP/dt decreased by 20% and cardiac output was unchanged. Left ventricular end-diastolic volume (15%) and end-diastolic pressure (40%) decreased, while ejection fraction slightly increased (13%). In normal hearts, nisoldipine reduces left ventricular pre- and afterload, without a depression of myocardial contractility, which results in a more efficient emptying of the left ventricle.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000494:pharmacology; D015737:Nisoldipine; D013318:Stroke Volume / Q000187:drug effects; D013552:Swine; D014655:Vascular Resistance / Q000187:drug effects
D015737:Nisoldipine; D009543:Nifedipine