The contractility of fibroblasts in a collagen lattice is reduced by corticosteroids.
Normal human and rat skin fibroblasts, incorporated into a three-dimensional collagen lattice, were assayed for their ability to contract collagen fibrils. This capacity is inhibited in a dose-dependent fashion by both dexamethasone and hydrocortisone. The inhibition is reversed when the corticosteroids are removed from the culture medium, but while the effect of hydrocortisone is almost entirely reversible, that of dexamethasone is not.
D000305:Adrenal Cortex Hormones / Q000494:pharmacology*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003094:Collagen / Q000502:physiology*; D003907:Dexamethasone / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D051381:Rats; D012867:Skin / Q000166:cytology
D000305:Adrenal Cortex Hormones; D003907:Dexamethasone; D003094:Collagen; D006854:Hydrocortisone