title: Plasma pentachlorophenol concentrations in calves exposed to treated wood in the environment.
abstract: Six calves were fed grain and hay from a pentachlorophenol (PCP)-treated feeder twice daily. Samples of blood were collected twice a week. Plasma PCP concentrations increased rapidly to a maximum of 1,086 microgram/L within 10 days. After the 3rd week, calves were denied access to the treated feeder; PCP values returned rapidly to near base line (before calves were fed from the treated feeder). After base-line plasma PCP values were reached, 4 of the 6 calves were housed in a total confinement building and exposed (by inhalation) to lumber that was commercially treated with PCP. The building itself was free of structural PCP-treated lumber. The ratio of building volume to treated wood surface was approximately 49 to 1. During the 3 weeks the calves were confined, PCP values did not increase and were markedly lower than those associated with oral exposure to treated wood. Oral dosing of calves with PCP in capsules--0.05 and 0.5 mg/kg--resulted in maximal plasma PCP values of 1,449 and 9,555 micrograms/L, respectively. Oral exposures (feeding from contaminated feeder; capsule) appeared to be more important than inhalation in causing increased plasma PCP concentrations in cattle. Exposure from these sources may be estimated by comparison with experimental values from dose-response studies. Feeding from treated feeders resulted in lower plasma PCP values than did dosing with 0.05 mg/kg daily.
mesh_terms: D000284:Administration, Oral; D000821:Animal Feed / Q000633:toxicity; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000139:chemically induced*; D002733:Chlorophenols / Q000097:blood*; D004781:Environmental Exposure; D005260:Female; D008297:Male; D010416:Pentachlorophenol / Q000008:administration & dosage / Q000097:blood* / Q000633:toxicity; D011247:Pregnancy; D014934:Wood
chemical_list: D002733:Chlorophenols; D010416:Pentachlorophenol