Simple method to predict digoxin serum concentration.
The predictability of a method of determining serum digoxin concentration was assessed in a retrospective study of 35 hospitalized patients taking digoxin orally for maintenance therapy. Simple pharmacokinetic expressions were used to estimate digoxin concentration. Clinically, the mean measured digoxin concentration (1.35 ng/ml) was in close agreement with the mean predicted value (1.36 ng/ml). There was also a strong statistical correlation between measured and predicted values (r = .82). The predictability of serum digoxin concentration was statistically equivalent in men and women. Our results indicate that a reasonably accurate prediction of digoxin concentration is possible using simple mathematical formulas that require only routine clinical data.
D000284:Administration, Oral; D000368:Aged; D004077:Digoxin / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008433:Mathematics; D008722:Methods; D008875:Middle Aged; D011336:Probability; D012189:Retrospective Studies
D004077:Digoxin