Cytotoxic effects of Eleutherococcus senticosus aqueous extracts in combination with N6-(delta 2-isopentenyl)-adenosine and 1-beta-D-arabinofuranosylcytosine against L1210 leukemia cells.
The use of the aqueous extracts of Eleutherococcus senticosus in combination with either cytarabine or N6-(delta 2-isopentenyl)-adenosine gave additive antiproliferative effects against L1210 murine leukemia. The ED50 for E. senticosus root extracts against L1210 cells was approximately 75 micrograms/mL. E. senticosus appears to be potentially useful for reducing the concentration of conventional antimetabolites used for their antiproliferative effects on tumor cells.
D000225:Adenine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic; D000971:Antineoplastic Combined Chemotherapy Protocols; D002455:Cell Division / Q000187:drug effects; D003561:Cytarabine / Q000627:therapeutic use*; D066298:In Vitro Techniques; D007541:Isopentenyladenosine; D007939:Leukemia L1210 / Q000188:drug therapy*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*
D000972:Antineoplastic Agents, Phytogenic; D010936:Plant Extracts; D003561:Cytarabine; C001478:N(6)-(delta(2)-isopentenyl)adenine; D007541:Isopentenyladenosine; D000225:Adenine