A gamma-detecting probe for radioimmune detection of CEA-producing tumors. Successful experimental use and clinical case report.
The detection of tumors with radiolabeled antibodies against CEA is possible; however, current nuclear medicine scanning cameras rarely detect tumors smaller than 2 cm in diameter. One of the limitations to tumor detection is the inability to place a detecting camera near a deeply seated intra-abdominal tumor. A hand-held gamma-detecting probe, suitable for intraoperative use, was designed to locate radioactive tumors. Experimental work with CEA-producing colon tumor xenografts in nude mice suggests this probe is more sensitive than external scanners in detecting small tumors. A case report documents the clinical use of this new intraoperative probe.
D000230:Adenocarcinoma / Q000032:analysis*; D000818:Animals; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D005720:Gamma Rays; D006801:Humans; D008297:Male; D051379:Mice; D008819:Mice, Nude; D008875:Middle Aged; D011863:Radioimmunoassay / Q000295:instrumentation* / Q000379:methods; D012004:Rectal Neoplasms / Q000032:analysis*
D002272:Carcinoembryonic Antigen