Effect of cyclophosphamide on the immune responsiveness of jirds infected with Brugia pahangi.
The in vitro immune responsiveness of lymphocytes from Brugia pahangi-infected jirds was examined after serial administration of cyclophosphamide (20 mg/kg). Cyclophosphamide had no effect on parasite burdens, anti-B. pahangi antibody titers, or suppressed spleen cell reactivity to B. pahangi antigens. Cyclophosphamide restored cellular responsiveness to the mitogens phytohemagglutinin, concanavalin A, and pokeweed mitogen.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D002009:Brugia; D003208:Concanavalin A / Q000494:pharmacology; D003520:Cyclophosphamide / Q000494:pharmacology*; D005368:Filariasis / Q000276:immunology*; D005849:Gerbillinae; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D010835:Phytohemagglutinins / Q000494:pharmacology; D011043:Pokeweed Mitogens / Q000494:pharmacology
D010835:Phytohemagglutinins; D011043:Pokeweed Mitogens; D003208:Concanavalin A; D003520:Cyclophosphamide