[Epidemiology of digitalis medication. Results of the Munich blood-pressure study].
As part of a blood-pressure survey in Munich, some of its inhabitants aged 30-69 years were asked by questionnaire about any digitalis medication. Chemically defined glycosides were taken by 127 of 1827 persons (7%), two-thirds of them older than 60 years, for clinically compensated chronic heart failure. Using the equation of Cockcroft and Gault to calculate creatinine clearance, it was below 80 ml/min and thus indicative of early impairment of renal function in more than 50%. In 44% the prescribed daily dose of glycoside corresponded to the calculated maintenance dose, 29% had less and 27% had taken more. None had clinical signs of digitalis intoxication. ECG changes possibly due to digitalis were much less common than had been expected. Sinus rhythm was present in 93%. More than 50% did not know why they were taking digitalis and 80% were taking two or more drugs at the same time. Since more than half had signs of early renal function impairment, creatinine clearance should be taken into account when determining the dosage of a digoxin preparation especially in elderly patients; alternatively, digitoxin should be prescribed. The survey also showed that a large number of persons on glycoside medication did not take the drug regularly.
D000113:Acetyldigoxins / Q000008:administration & dosage; D000328:Adult; D000367:Age Factors; D000368:Aged; D003404:Creatinine / Q000652:urine; D004071:Digitalis Glycosides / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004074:Digitoxin / Q000008:administration & dosage; D004077:Digoxin / Q000008:administration & dosage; D004562:Electrocardiography; D005260:Female; D005860:Germany, West; D006321:Heart / Q000187:drug effects; D006331:Heart Diseases / Q000188:drug therapy; D006801:Humans; D006973:Hypertension / Q000453:epidemiology*; D007668:Kidney / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012737:Sex Factors
D000113:Acetyldigoxins; D004071:Digitalis Glycosides; D004077:Digoxin; D003404:Creatinine; D004074:Digitoxin
Zur Epidemiologie der Digitalismedikation. Ergebnisse der Münchner Blutdruckstudie.