Hepatotoxicity associated with maprotiline therapy: case report.
The author reports a case of markedly elevated liver enzymes associated with maprotiline therapy for depression. The patient was cachexic but was anicteric and had no evidence of viral hepatitis. The serum enzyme levels returned to normal shortly after the medication was discontinued.
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D000873:Anthracenes / Q000009:adverse effects*; D001219:Aspartate Aminotransferases / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury; D003866:Depressive Disorder / Q000188:drug therapy; D005260:Female; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008099:Liver / Q000201:enzymology; D008107:Liver Diseases / Q000201:enzymology; D008376:Maprotiline / Q000009:adverse effects*
D000873:Anthracenes; D008376:Maprotiline; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D000469:Alkaline Phosphatase