The Noble rat bladder cancer model. FANFT-induced tumors.
This laboratory unit has been working with the Nb rat prostate adenocarcinoma model for the last several years and has recently used this model system to study efficacy of various chemotherapeutic agents in FANFT-induced bladder carcinomas in this rat strain. The purpose of this project is to identify factors and chemotherapeutic agents that might be useful for treatment of human bladder carcinoma. It is proposed that the use of the Nb rat be utilized to develop a data base to advance understanding of the management of bladder carcinoma induced by FANFT ingestion in Nb rats. Conventional cytotoxic agents and new combination chemotherapy will be utilized intravesically and systemically.
D000818:Animals; D002467:Cell Nucleus / Q000473:pathology; D003520:Cyclophosphamide / Q000627:therapeutic use; D003593:Cytoplasm / Q000473:pathology; D004195:Disease Models, Animal; D005200:FANFT; D005260:Female; D051381:Rats; D011919:Rats, Inbred Strains; D013844:Thiazoles; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000517:prevention & control
D013844:Thiazoles; D005200:FANFT; D003520:Cyclophosphamide