Enhancement of chemiluminescence of the neutrophils by low concentrations of trifluoperazine.
One to 10 microM trifluoperazine was found to potentiate luminol-dependent chemiluminescence of neutrophils induced by n-formyl-methionyl-leucyl-phenyalanine. It did not potentiate chemiluminescence induced by A23187 or by phorbor myristate acetate. Low concentrations of another calmodulin antagonist N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, an intracellular Ca++ antagonist 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxybenzoate, and a local anesthetic dibucaine, were found to possess similar activity. It is suggested that trifluoperazine potentiates chemiluminescence by acting on certain cellular processes that follow after stimulation by n-formyl-methionyl-leucyl-phenylalanine, but not by A23187 or by phorbor myristate acetate, and that this effect may be calmodulin-independent.
D003992:Dibucaine / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008163:Luminescent Measurements; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D014268:Trifluoperazine / Q000494:pharmacology*
D014268:Trifluoperazine; D009240:N-Formylmethionine Leucyl-Phenylalanine; D003992:Dibucaine