Chrysosporium, a new causative agent in osteomyelitis. A case report.
A 24-year-old black man presented with a two-month history of swelling of the right ankle. Roentgenograms were initially read as negative. One month later the patient returned with increased pain and swelling, and roentgenograms demonstrated a large lucency involving the distal tibia. Bone scanning revealed extension of the lesion proximally, to 6 cm below the knee. Biopsy of a large tibial abscess demonstrated histocytic giant cells with budding yeasts and septate mycelia. Chrysosporium was isolated from cultures. Amphotericin B was used to treat the patient. Clinically, the infection healed within four months in a short-leg cast. Although Chrysosporium is usually a contaminant, its presence in cultures and histologic sections is evidence of pathogenicity.
D000328:Adult; D006801:Humans; D008297:Male; D003904:Mitosporic Fungi; D009181:Mycoses / Q000000981:diagnostic imaging* / Q000628:therapy; D010019:Osteomyelitis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000628:therapy; D011859:Radiography; D013977:Tibia