Effects of bronchodilation on magnitude estimation of added resistive loads in asthmatic subjects.
The magnitude estimation of 6 added resistive loads (delta R), ranging from 2.7 to 22.5 cmH2O/L/s, was studied in 7 normal and 6 stable asthmatic subjects. Each subject squeezed a handgrip dynamometer to indicate load magnitude. The magnitude estimation of a range of 5 weights, from 0.1 to 1.0 kg, placed on the hand was also assessed by dynamometry and numerical estimation. Airways resistance and spirometry were measured in each group. Metaproterenol, 0.13 mg, was then given by inhalation; after 15 min, the complete study was repeated. There was a significant bronchodilation in the asthmatic subjects, with a subjective decrease in chest "tightness," but no significant change in the normal subjects. In the control state, the perceived magnitude (psi) of delta R could be expressed by the relationship: psi = K. delta R beta, in accordance with Stevens' law. There was no significant difference (p greater than 0.05) in the value of beta between the normal and asthmatic group (0.55 and 0.67, respectively). However, the y-intercept in the control state was significantly greater in the asthmatics; when the perceived magnitude was expressed in terms of the mouth pressure (Pm) during the loaded breath in the control state, i.e., psi = K.Pm beta, there was no significant difference, either in beta or in the y-intercept. These results suggest that psi is related to Pm and is greater for any delta R in asthmatics because Pm is increased.(ABSTRACT TRUNCATED AT 250 WORDS)
D000403:Airway Resistance; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D001980:Bronchi / Q000503:physiopathology; D006801:Humans; D009921:Metaproterenol / Q000627:therapeutic use*; D011312:Pressure; D012119:Respiration; D012677:Sensation / Q000502:physiology*
D009921:Metaproterenol