Cytotoxicity of cyclophosphamide and acrylamide in glioma and neuroblastoma cell lines cocultured with liver cells.
A method for the cocultivation of nervous system cells with liver cells has been developed. When acrylamide was tested using the cocultivation procedure no significant liver metabolism-mediated changes in the cytotoxicity in C6 culture were detected. In neuroblastoma N1E115 cultures the toxicity was increased by induced chick hepatocytes at high acrylamide concentrations.
D020106:Acrylamide; D000178:Acrylamides / Q000633:toxicity*; D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002642:Chick Embryo; D003520:Cyclophosphamide / Q000633:toxicity*; D005910:Glioma / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D051379:Mice; D009447:Neuroblastoma / Q000378:metabolism; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D051381:Rats
D000178:Acrylamides; D020106:Acrylamide; D003520:Cyclophosphamide