Cathepsin D stimulates DNA synthesis and mitosis in mouse liver in vivo.
Effects of a single intraperitoneal injection of cathepsin D (CatD) on DNA synthesis and mitosis in the mouse liver and kidney were investigated. Twenty micrograms of catD induced a significant stimulation of DNA synthesis in the liver, but not in the kidney, in a dose-dependent fashion and with a peak activity at 38 h after the injection. CatD also stimulated liver mitosis, with a peak value at 44 h after the injection.
D000818:Animals; D002402:Cathepsin D; D002403:Cathepsins / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects; D004261:DNA Replication / Q000187:drug effects; D007668:Kidney / Q000166:cytology*; D008099:Liver / Q000166:cytology*; D008297:Male; D051379:Mice; D008938:Mitosis / Q000187:drug effects*
D002403:Cathepsins; D002402:Cathepsin D