Cortical blindness after metrizamide myelography. Report of a case and proposed pathophysiologic mechanism.
Metrizamide, a nonionic, water-soluble contrast medium, has been increasingly used for myelography. We saw a patient with cortical blindness, seizure, organic psychosis, and asterixis after undergoing attempted metrizamide myelography via C1-2 puncture. Computed tomography demonstrated early penetrance of metrizamide into the brain parenchyma, most prominently in the occipital lobes. A mechanism of direct metrizamide neurotoxicity was proposed.
D000328:Adult; D001766:Blindness / Q000209:etiology* / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology; D002540:Cerebral Cortex / Q000503:physiopathology; D006801:Humans; D008297:Male; D008793:Metrizamide / Q000009:adverse effects*; D009192:Myelography
D008793:Metrizamide