In vivo suppression of Ehrlich ascites carcinoma by human antibody-dependent splenocytes.
Inbred CFW/L1 mice were inoculated i. p. with Ehrlich ascites carcinoma (EAC) cells. Two and a half hours later they were given i. p. injection of human splenocytes or rabbit anti-EAC serum, or human splenocytes together with rabbit anti-EAC serum. When given alone splenocytes did not exert any antitumor effect. Anti-EAC serum given alone inhibited tumor growth in 50% of mice. Simultaneous application of splenocytes and antiserum inhibited tumor growth in 85% of mice. In vitro experiment suggests that antibody-dependent cellular cytotoxicity (ADCC) may be responsible for the observed antitumor effect in vivo.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000008:administration & dosage*; D000920:Antibody-Dependent Cell Cytotoxicity; D002286:Carcinoma, Ehrlich Tumor / Q000473:pathology / Q000628:therapy*; D002460:Cell Line; D005260:Female; D006801:Humans; D051379:Mice; D009368:Neoplasm Transplantation; D011817:Rabbits; D013154:Spleen / Q000637:transplantation*
D000912:Antibodies, Neoplasm