Teratogenic assessment of three methylated hydrazine derivatives in the rat.
The embryotoxicity and teratogenicity of methylhydrazine, 1,1-dimethylhydrazine, and 1,2-dimethylhydrazine were investigated with pregnant Fischer-344 rats. The compounds were administered ip on d 6-15 of pregnancy. A dose-dependent reduction in maternal weight gains occurred for all three compounds. A dose-related teratogenic effect did not occur for any of the three compounds. Embryotoxicity, manifested as reduced 20-d fetal weights, occurred only in the 1,1-dimethylhydrazine and 1,2-dimethylhydrazine high-dose treatment groups. The results indicate that none of the three methylated hydrazine derivatives are selectively embryotoxic or teratogenic in the rat.
D019813:1,2-Dimethylhydrazine; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004127:Dimethylhydrazines / Q000633:toxicity*; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D007274:Injections, Intraperitoneal; D008763:Methylhydrazines / Q000633:toxicity*; D009002:Monomethylhydrazine / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D011916:Rats, Inbred F344; D013723:Teratogens / Q000633:toxicity*
D004127:Dimethylhydrazines; D008763:Methylhydrazines; D013723:Teratogens; C013958:dimazine; D019813:1,2-Dimethylhydrazine; D009002:Monomethylhydrazine