Identification of a murine pregnancy-associated serum protein (alpha 1-PAP) a female-specific acute-phase reactant.
A murine pregnancy-associated protein (alpha 1-PAP) with alpha 1-electrophoretic mobility and an estimated molecular weight of 150 000 was present in serum from pregnant C57BL/10 mice but could not be detected in serum of mature non-pregnant females and males. During pregnancy alpha 1-PAP was first detected on Day 7, rose to maximum levels between Days 12 and 14, and thereafter declined during the remainder of pregnancy and was undetectable by Day 8 post partum. The protein was also detected in the serum of females, but not males, subjected to an inflammatory stimulus. Examination of the alpha 1-PAP levels during an acute-phase response in females demonstrated that the protein behaved as a typical classical acute-phase reactant, although the levels were only 10% of those observed during Days 12 to 14 of pregnancy. alpha 1-PAP therefore appears to represent a hitherto undescribed female-specific acute phase reactant in the mouse.
D000682:Amyloid / Q000097:blood; D000818:Animals; D002850:Chromatography, Gel; D002852:Chromatography, Ion Exchange; D005260:Female; D007122:Immunoelectrophoresis; D007123:Immunoelectrophoresis, Two-Dimensional; D007249:Inflammation / Q000097:blood*; D051379:Mice; D008815:Mice, Inbred Strains; D008970:Molecular Weight; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000097:blood*; D011270:Pregnancy, Animal; D000683:Serum Amyloid P-Component; D012737:Sex Factors
D000682:Amyloid; D011257:Pregnancy Proteins; D000683:Serum Amyloid P-Component