Teratogenicity of 2.3.7.8-tetrachlorodibenzofuran (TCDF) in mice.
Treatment of pregnant C57BL/6N mice with 2,3,7,8-tetrachlorodibenzofuran (TCDF) (0, 250, 500, and 1000 micrograms/kg on gestation day 10 or 0, 10, 30, 50, and 100 micrograms/kg on gestation days 10-13) results in dose-related increases in isolated cleft palates and hydronephrotic kidneys in the offspring. TCDF is teratogenic in 100% of the fetuses at dose levels that are not maternally toxic. The fetal kidney is the most sensitive target organ but the kidney lesions may be reversible.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D001572:Benzofurans / Q000633:toxicity*; D002972:Cleft Palate / Q000139:chemically induced*; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005865:Gestational Age; D006869:Hydronephrosis / Q000139:chemically induced*; D008431:Maternal-Fetal Exchange; D051379:Mice; D008810:Mice, Inbred C57BL; D011247:Pregnancy; D013723:Teratogens
D001572:Benzofurans; D013723:Teratogens; C014211:2,3,7,8-tetrachlorodibenzofuran