title: Development of additional primary tumors after 62 years in the first patient with retinoblastoma cured by radiation therapy.
abstract: In the first well-documented case of bilateral retinoblastoma to be cured by X-irradiation of the nonenucleated eye, a basal cell carcinoma and then a squamous cell carcinoma of the eyelids developed 60 years after the original treatment. The patient, a 66-year-old man, had been treated by Verhoeff between 1917 and 1919. These new tumors may have been examples of second primary tumors, found in about 0.5% to 2.5% of patients with bilateral retinoblastoma, or they may have been coincidental. Because of the 60-year period between the patient's original treatment and the development of these tumors, it seems unlikely that they were the result of the irradiation.
mesh_terms: D002280:Basal Cell Carcinoma / Q000209:etiology / Q000473:pathology*; D002294:Carcinoma, Squamous Cell / Q000209:etiology / Q000473:pathology*; D005134:Eye Neoplasms / Q000532:radiotherapy*; D005142:Eyelid Neoplasms / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology; D011879:Radiotherapy Dosage; D012175:Retinoblastoma / Q000532:radiotherapy*; D013997:Time Factors