title: Differential renal and splenic nerve responses to vagal and spinal afferent inputs.
abstract: Specific contributions of the kidney and spleen to cardiovascular homeostasis may be determined partially by differential sympathetic influences on each organ. This investigation was a comparison of renal and splenic sympathetic responses to stimulation of vagally innervated cardiac receptors and receptors of abdominal visceral and muscle spinal afferent nerves. Experiments were performed in anesthetized, sinoaortic-denervated cats in which upper thoracic sympathetic ganglia had been removed. Left atrial injections of veratridine depressed renal and splenic nerve discharges by 68 and 44%, respectively. In contrast, injections of bradykinin into the abdominal aorta caused 18 and 104% excitation of renal and splenic nerves, respectively. Visceral ischemia and mesenteric stretch by snare occlusion of the celiac artery caused 20 and 64% excitation of renal and splenic nerves, respectively. Left atrial injections of bradykinin caused biphasic renal nerve responses (range, 200% excitation to complete inhibition) and 246% excitation of splenic nerves; after vagotomy both renal and splenic nerves were excited (21 and 117%, respectively). In conclusion, sympathetic control of the kidney and spleen can be selective, illustrating significant potential discreteness of sympathetic outflow to the viscera.
mesh_terms: D000818:Animals; D001157:Arterial Occlusive Diseases / Q000503:physiopathology; D001920:Bradykinin / Q000008:administration & dosage / Q000494:pharmacology; D002415:Cats; D002445:Celiac Artery; D007668:Kidney / Q000294:innervation*; D009475:Neurons, Afferent / Q000502:physiology*; D013153:Splanchnic Nerves / Q000502:physiology; D013154:Spleen / Q000294:innervation*; D014630:Vagus Nerve / Q000502:physiology*; D014701:Veratridine / Q000494:pharmacology
chemical_list: D014701:Veratridine; D001920:Bradykinin