title: Recovery of neocortical choline acetyltransferase activity following ibotenic acid injection into the nucleus basalis of Meynert in rats.
abstract: The present experiment was designed to investigate the depletion and possible recovery of neocortical choline acetyltransferase (ChAT) levels following damage to the basal forebrain cholinergic (Ch) system in rats. A unilateral injection of ibotenic acid was made into the left nucleus basalis of Meynert (nbM). Seven days after the injection, neocortical ChAT levels had decreased 60%. After 3 months it had returned to normal. Thus this system shows extensive plasticity and recovery of function with time.
mesh_terms: D000818:Animals; D001479:Basal Ganglia / Q000502:physiology*; D002540:Cerebral Cortex / Q000201:enzymology / Q000502:physiology*; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D002799:Cholinergic Fibers / Q000502:physiology; D007051:Ibotenic Acid / Q000494:pharmacology*; D008297:Male; D009434:Neural Pathways / Q000502:physiology; D009473:Neuronal Plasticity; D010080:Oxazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013377:Substantia Innominata / Q000187:drug effects / Q000502:physiology*
chemical_list: D010080:Oxazoles; D007051:Ibotenic Acid; D002795:Choline O-Acetyltransferase