[Features of the effect of various doses of adrenaline on the release of blood clotting factors and anticoagulants into the bloodstream by the intestine].
Moderate doses (2-7 micrograms/kg) of adrenaline (A) enhanced the coagulating activity of the cat intestine perfusate sharply increasing the release of thromboplastine, antiheparin compounds, analogues of the V and XIII factors and depressing the release of antithromboplastines. Large doses of A (100 micrograms/kg) decreased the perfusate procoagulating activity accelerating the release of tissue antithromboplastines. The findings suggest an ability of large doses of A to induce a moderate hypocoagulemia due to the release of antithromboplastic substances from tissues into the blood flow.
D000818:Animals; D001779:Blood Coagulation Factors / Q000378:metabolism*; D002415:Cats; D004837:Epinephrine / Q000008:administration & dosage*; D005165:Factor V / Q000378:metabolism; D005176:Factor XIII / Q000378:metabolism; D005260:Female; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D010978:Platelet Factor 4 / Q000378:metabolism; D013925:Thromboplastin / Q000037:antagonists & inhibitors / Q000378:metabolism
D001779:Blood Coagulation Factors; D010978:Platelet Factor 4; D005165:Factor V; D005176:Factor XIII; D013925:Thromboplastin; D004837:Epinephrine
Osobennosti vliianiia adrenalina v razlichnykh dozakh na osvobozhdenie kishechnikom faktorov gemokoaguliatsii i antikoaguliantov v krovenosnoe ruslo.