Intravitreal 5-fluorouracil in the prevention of post-traumatic vitreous proliferation.
We created double perforating injuries in both eyes of 24 rabbits. Into the vitreous cavity of one eye of each rabbit we injected 1 mg 5-fluorouracil (5-FU). After 2 months the eyes treated with 5-FU showed significantly less intraocular proliferation than the saline-treated control eyes.
D000818:Animals; D005128:Eye Diseases / Q000188:drug therapy; D005131:Eye Injuries / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D011817:Rabbits; D014822:Vitreous Body / Q000187:drug effects*
D005472:Fluorouracil