Immunoactive products of murine placenta. II.--Afferent suppression of maternal cell-mediated immunity by supernatants from short-term cultures of murine trophoblast-enriched cell suspensions.
Supernatants from short-term cultures of mid-term murine trophoblast cells were assayed for their in vitro regulatory potential. They markedly inhibited cell-mediated lympholysis and mixed lymphocyte reaction in a non-specific, non-restricted fashion. By contrast, the mitogenic response to optimal doses of ConA was unaffected, while the plaque-forming cell response to sheep red blood cells was either unmodified or slightly enhanced. These data suggest that placenta-derived cells secrete factors which selectively impair some cell-mediated immune responses. It is suggested that these factors play an important role in the lack of generation of cytolytic T lymphocytes towards paternal alloantigens expressed on the trophoblast during allopregnancy.
D000818:Animals; D002478:Cells, Cultured; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects; D007165:Immunosuppression Therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D010920:Placenta / Q000032:analysis / Q000276:immunology*; D011247:Pregnancy; D013997:Time Factors; D014020:Tissue Extracts / Q000276:immunology*; D014327:Trophoblasts / Q000276:immunology*
D014020:Tissue Extracts