Pathologic hyperfibrinolysis associated with amyloidosis: clinical response to epsilon amino caproic acid.
Severe bleeding diathesis was the presenting problem in a patient with systemic amyloidosis characterized by generalized amyloid adenopathy. Epsilon amino caproic acid effectively reversed the fibrinolytic state with improvement of bleeding tendency and reduction of lymphadenopathy. The possible relationship and mechanisms of fibrinolysis are discussed.
D000614:Aminocaproates / Q000627:therapeutic use*; D015119:Aminocaproic Acid / Q000627:therapeutic use*; D000686:Amyloidosis / Q000150:complications*; D005342:Fibrinolysis; D006474:Hemorrhagic Disorders / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009333:Neck
D000614:Aminocaproates; D015119:Aminocaproic Acid