Effect of methadone on TSH and thyroid hormone secretion.
The hypothalamus-pituitary-thyroid function was studied in 15 male patients on chronic methadone treatment (40 mg/day). No significant variations of TSH, T4, T3 and rT3 levels were documented, either in basal conditions or after TRH stimulation; however a reduced TSH pituitary response was recorded in some patients (6 out of 15).
D000328:Adult; D006801:Humans; D008297:Male; D008691:Methadone / Q000494:pharmacology*; D009293:Opioid-Related Disorders / Q000097:blood* / Q000534:rehabilitation; D013963:Thyroid Hormones / Q000097:blood*; D013972:Thyrotropin / Q000097:blood*
D013963:Thyroid Hormones; D013972:Thyrotropin; D008691:Methadone