Liquid-chromatographic evaluation of age-related changes in the urinary excretion of free catecholamines in pediatric patients.
Pediatric patients (to age 18) without neuroblastoma show an age-related decrease in urinary excretion of each of the catecholamines--epinephrine, norepinephrine, and dopamine--in relation to creatinine excretion. From these data, I have developed reference intervals for pediatric age groups. Application of these ranges to seven patients with neuroblastoma and ganglioneuroblastoma indicated a high clinical sensitivity for the urinary dopamine determination but significant false-negative results for epinephrine and norepinephrine.
D000293:Adolescent; D000367:Age Factors; D002395:Catecholamines / Q000652:urine*; D002648:Child; D002675:Child, Preschool; D002853:Chromatography, Liquid; D004298:Dopamine / Q000652:urine; D004837:Epinephrine / Q000652:urine; D005729:Ganglioneuroma / Q000652:urine; D006801:Humans; D007223:Infant; D009447:Neuroblastoma / Q000652:urine; D009638:Norepinephrine / Q000652:urine; D012016:Reference Values
D002395:Catecholamines; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine