Ethanol inhibition of phencyclidine percutaneous absorption.
The effect of parenterally administered ethanol on the percutaneous absorption of phencyclidine hydrochloride was investigated using the intact hairless (SKH, hr-1/hr-1) mouse as a model. Four hours after topical application of phencyclidine hydrochloride, the mean phencyclidine concentration (129.2 ng/g) in excised liver was significantly lower in mice that had received ethanol by intraperitoneal injection than in mice injected intraperitoneally with water (1730.1 ng/g) (p less than 0.01). When phencyclidine hydrochloride was administered by intraperitoneal injection there was no statistically significant difference between the mean concentration in liver (3442.5 ng/g) for ethanol-treated mice and that (3030.3 ng/g) for the control mice (p greater than 0.10), indicating that the observed difference was not due to enhancement of phencyclidine metabolism by ethanol. These findings suggest that ethanol inhibits the percutaneous absorption of phencyclidine hydrochloride.
D000287:Administration, Topical; D000818:Animals; D000431:Ethanol / Q000494:pharmacology*; D006801:Humans; D007274:Injections, Intraperitoneal; D008099:Liver / Q000032:analysis; D008297:Male; D051379:Mice; D008812:Mice, Hairless; D010622:Phencyclidine / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D012867:Skin / Q000187:drug effects / Q000378:metabolism*
D000431:Ethanol; D010622:Phencyclidine