title: [Characteristics of thiol metabolism in animals in extreme thyroxine loading].
abstract: Circadian and long-term dynamics of alterations in protein concentration, in content of SH- and SS-groups was studied in rat tissues under conditions of normal state as well as after administration of thyroxin within 10 days at a dose of 10 mg/kg of body mass and after discontinuation of the treatment. Biphase circadian rhythms of thiol turnover, observed in controls, were shown to shift from 7 and 19 hrs to 11 and 23 hrs (the time of the animals feeding) when thyroxin toxicosis amplified. In the thyroxin toxicosis alterations of biological and biochemical patterns within the 3.5 days period were found, time-dependent appearance of thyroxin crisis was also noted in the rats due to superimpose of circadian and long-term alterations in content of SH-groups as well as a result of distinct decrease in the total amount of thiols within these periods. The thyroxin toxicosis was shown to alter also the body and tissue sensitivity to the injuring effect of hydrogen sulfide, maximal manifestation of which was observed at the periods of thyrotoxic crisis.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002940:Circadian Rhythm / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D013438:Sulfhydryl Compounds / Q000097:blood / Q000378:metabolism*; D013950:Thymus Gland / Q000378:metabolism; D013974:Thyroxine / Q000097:blood / Q000506:poisoning*
chemical_list: D013438:Sulfhydryl Compounds; D013974:Thyroxine
vernacular_title: Osobennosti tiolovogo obmena u zhivotnykh pri ékstremal'noĭ tiroksinovoĭ nagruzke.