Stabilized normal-phase high-performance liquid chromatographic analysis of aspirin and salicylic acid in solid pharmaceutical dosage forms.
A simultaneous analysis of aspirin and nonaspirin salicylates in solid pharmaceutical dosage forms is described. Two separate extraction procedures are employed, one for plain aspirin tablets and one for tablets containing aspirin plus buffers or antacids. The analyses of the extracted samples are accomplished by a stabilized normal-phase high-performance liquid chromatographic (HPLC) procedure. Prepared samples and standards are stable for up to 24 h, and the methodology is suitable for an automated HPLC system.
D000863:Antacids / Q000032:analysis; D001241:Aspirin / Q000032:analysis*; D002021:Buffers / Q000032:analysis; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D012459:Salicylates / Q000032:analysis*; D020156:Salicylic Acid; D013607:Tablets / Q000032:analysis
D000863:Antacids; D002021:Buffers; D012459:Salicylates; D013607:Tablets; D020156:Salicylic Acid; D001241:Aspirin