title: [Comparison of the antihypoxic effect of alpha-tocopherol, NAD and inosine during prolonged artificial circulation].
abstract: Mathematical analysis was used to compare the antihypoxic action of alpha-tocopherol, inosine and oxidized NAD under long-term extracorporeal circulation. Of the drugs studied, oxidized NAD form was demonstrated to be the most active, inosine appeared less active, and alpha-tocopherol still less active. It is advisable to study more thoroughly the effect of oxidized NAD under long-term extracorporeal circulation.
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D005112:Extracorporeal Circulation; D006439:Hemodynamics / Q000187:drug effects; D000860:Hypoxia / Q000517:prevention & control*; D007288:Inosine / Q000627:therapeutic use*; D008433:Mathematics; D009243:NAD / Q000627:therapeutic use*; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D009243:NAD; D014810:Vitamin E; D007288:Inosine
vernacular_title: Sopostavlenie protivogipoksicheskogo éffekta al'fa-tokoferola, NAD i inozina pri dlitel'nom iskusstvennom krovoobrashchenii.