title: Influence of zinc, D-penicillamine and oxygen on poisoning with Amanita phalloides. Zinc accelerates liver regeneration and prevents the depletion of brain noradrenaline caused by the mushroom.
abstract: Pretreatment with zinc aspartate increased the survival rate of mice poisoned with a lyophilisate from the mushroom Amanita phalloides (APL). In the livers of the zinc-treated animals, confluent necrosis was cleared earlier. Zinc also prevented the reduction of brain noradrenaline caused by the mushroom as well as the rise of brain dopamine and brain weight. D-Penicillamine also protected against the lethal effects of APL. The survival afforded by zinc pretreatment was marginally ameliorated by additional oxygenation.
mesh_terms: D000545:Amanita; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D005260:Female; D007928:Lethal Dose 50; D008099:Liver / Q000473:pathology; D008115:Liver Regeneration / Q000187:drug effects; D051379:Mice; D009145:Mushroom Poisoning / Q000188:drug therapy* / Q000473:pathology; D009638:Norepinephrine / Q000378:metabolism; D010102:Oxygen Inhalation Therapy; D010396:Penicillamine / Q000627:therapeutic use*; D015032:Zinc / Q000627:therapeutic use*
chemical_list: D010396:Penicillamine; D015032:Zinc; D004298:Dopamine; D009638:Norepinephrine