Role of Tromaril as anti-prostaglandin drug on blood aqueous barrier.
In this experimental work, it was observed that after anterior chamber paracentesis there was more effusion of protein into the anterior chamber. Pretreatment with aspirin/indomethacin and a new drug, enfenamic acid (Tromaril), decreased this trauma-induced increase in aqueous protein content. It was further observed that this inhibition was more marked with Tromaril pretreatment in comparison with other drugs. Prostaglandin-mediated disruption of blood aqueous barrier can also be decreased with Tromaril pretreatment. Tromaril, a prostaglandin synthetase inhibitor, may help us to control the reactions to surgical ocular trauma and other ocular inflammatory diseases.
D000818:Animals; D001082:Aqueous Humor / Q000032:analysis / Q000187:drug effects*; D001769:Blood / Q000187:drug effects; D005123:Eye / Q000098:blood supply; D005136:Eye Proteins / Q000032:analysis; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011817:Rabbits; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D005136:Eye Proteins; D011448:Prostaglandin Antagonists; D062367:ortho-Aminobenzoates; C019126:enfenamic acid