Nerve terminal degeneration after a single injection of D-amphetamine in iprindole-treated rats: relation to selective long-lasting dopamine depletion.
A single injection of D-amphetamine has recently been shown to produce long-lasting dopamine (DA) deficits in rats pretreated with iprindole, an agent which interferes with the metabolism of amphetamine and prolongs its half-life. The basis for these persistent DA deficits has not been determined. The present results suggest that amphetamine produces prolonged DA depletions in iprindole-treated rats by destroying DA nerve terminals.
D000818:Animals; D003342:Corpus Striatum / Q000032:analysis / Q000187:drug effects*; D003913:Dextroamphetamine / Q000008:administration & dosage*; D004298:Dopamine / Q000032:analysis*; D004357:Drug Synergism; D007211:Indoles / Q000008:administration & dosage*; D007488:Iprindole / Q000008:administration & dosage*; D008297:Male; D009411:Nerve Endings / Q000187:drug effects; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000032:analysis
D007211:Indoles; D012701:Serotonin; D007488:Iprindole; D003913:Dextroamphetamine; D004298:Dopamine; D009638:Norepinephrine