Effects of L-carnitine on adriamycin-induced cardiomyopathy in rabbit.
The authors conducted an investigation in order to ascertain whether or not L-carnitine, by promoting the utilization of FFA for energy and neutralizing FFA toxicity occurring after ischaemia, could prevent or confine adriamycin-induced cardiotoxicity in rabbits. The results show that L-carnitine determines a higher survival rate and reduced onset of cardiomyopathy. Histopathological examination of myocardial tissue under light and electron microscopy revealed a marked decrease in mitochondrial lesions.
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D002331:Carnitine / Q000494:pharmacology* / Q000627:therapeutic use*; D004317:Doxorubicin / Q000633:toxicity*; D008297:Male; D008929:Mitochondria, Heart / Q000187:drug effects / Q000648:ultrastructure; D009206:Myocardium / Q000648:ultrastructure; D011817:Rabbits
D004317:Doxorubicin; D002331:Carnitine