title: [Toxicological aspects of fatal chloroquine poisoning over a period of several days].
abstract: The anti-inflammatory and antimalarial drug chloroquine is said to be one of the most frequently used drugs to commit suicide in the Orient and Far East. After the ingestion of large amounts of this 4-amino-chinoline derivate, signs of cardiac conduction disturbances are evidence of cardiotoxic action. For clinical treatment, hemoperfusion by activated charcoal has rather than hemodialysis proved to be partly effective for the removal of the toxic substance. Following a suicidal overdose of chloroquine tablets in a 13-year-old boy, we could confirm the efficiency of hemoperfusion by continued toxicologic examinations. The total elimination was nevertheless slow. Due to high postmortem concentrations in the blood and tissues, we believe that chloroquine is deposited and especially concentrated in the reticulohistiocytary system of the liver. Death after 5 days of clinical treatment in this case may be referred to as the first cardiac arrest with irreversible hypoxic damage of the brain.
mesh_terms: D000293:Adolescent; D001344:Autopsy; D002738:Chloroquine / Q000032:analysis / Q000097:blood / Q000506:poisoning*; D005554:Forensic Medicine; D006801:Humans; D008297:Male; D013405:Suicide; D013997:Time Factors
chemical_list: D002738:Chloroquine
vernacular_title: Toxikologische Aspekte beim mehrtägigen Verlauf einer tödlichen Chloroquin-Intoxikation.