The effect of cadmium, zinc or copper loading on the metabolism of amino acids in mouse liver.
Cadmium (Cd), zinc (Zn), and cupric chlorides (Cu) were injected i.p. into male mice to examine the effect of the metals on the concentration of amino acids in the liver. It is suggested that after injection some of the cysteine released from glutathione in the liver is incorporated into metallothionein and some is catabolized to taurine, while some of the glutamate released from glutathione is metabolized via aspartate. None of the sulfur-containing amino acids (oxidised metabolites of cysteine) were detected except for taurine in the present experiment.
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D019256:Cadmium Chloride; D002712:Chlorides; D003300:Copper / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015032:Zinc / Q000494:pharmacology*; D017967:Zinc Compounds
D000596:Amino Acids; D002712:Chlorides; D017967:Zinc Compounds; D002104:Cadmium; D003300:Copper; C016837:zinc chloride; D015032:Zinc; D019256:Cadmium Chloride; C029892:cupric chloride