[Indicators of phospholipase activity, lipid peroxidation and antioxidants in bronchial secretions from children with bronchopulmonary diseases].
Lipid peroxidation, activity of phospholipases and antioxidants were studied in bronchial secretion products of 5-14 years old children with bronchial asthma. During the acute period of the disease of lipid peroxidation as shown by estimation of hydroperoxides, malone dialdehyde, diene conjugates and Shiff bases and the activity of endogenous phospholipases were distinctly stimulated. Simultaneously, deficiency of endogenous antioxidants, especially of beta-carotin, was observed in the bronchopulmonary system. Content of peroxides and the activity of phospholipases tended to decrease in bronchial secretion products during the periods of remission. The alterations found correlated with the severity of the disease. Role of lipid peroxidation in development of bronchial asthma is discussed.
D000293:Adolescent; D000975:Antioxidants / Q000378:metabolism*; D001249:Asthma / Q000201:enzymology / Q000378:metabolism*; D001980:Bronchi / Q000201:enzymology / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D008054:Lipid Peroxides / Q000378:metabolism*; D010740:Phospholipases / Q000378:metabolism*; D012075:Remission, Spontaneous
D000975:Antioxidants; D008054:Lipid Peroxides; D010740:Phospholipases
Pokazateli aktivnosti fosfolipaz, perekisnogo okisleniia lipidov i antioksidantov v bronkhial'nom sekrete u deteĭ pri bronkholegochnykh zabolevaniiakh.