Synthesis of analogs and oligomers of N-(2-aminoethyl)glycine and their gastrointestinal absorption in the rat.
The synthesis of a series of analogs and oligomers of N-(2-aminoethyl)glycine (Aeg) are described. The gastrointestinal absorption of these compounds was determined after intragastric administration. Analogs of Aeg bearing a substituent at the amino or carboxyl functions were absorbed to a lesser extent than the parent compound. In contrast, the di- and tetra-oligomers of Aeg were more rapidly absorbed. Total absorption of these compounds was observed within 2 h after intragastric administration.
D000818:Animals; D005260:Female; D005998:Glycine / Q000031:analogs & derivatives*; D007202:Indicators and Reagents; D007408:Intestinal Absorption; D007700:Kinetics; D051381:Rats; D013329:Structure-Activity Relationship
D007202:Indicators and Reagents; C028791:N-(2-aminoethyl)glycine; D005998:Glycine