Hypersensitivity to non-steroidal anti-inflammatory drugs--asthma precipitated by zomepirac. A case report.
Non-steroidal anti-inflammatory agents can precipitate an asthma attack of varying severity. The most likely mechanism is the inhibition of the production of prostaglandin E with a concomitant increase in the production of the leukotrienes. A case in which an attack of asthma was precipitated by ingestion of 50 mg zomepirac (Zomax) and the patient responded to inhaled fenoterol is described. We conclude that zomepirac can cause reversible airflow limitation.
D000700:Analgesics / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects; D001249:Asthma / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011758:Pyrroles / Q000009:adverse effects*; D013997:Time Factors; D014046:Tolmetin / Q000009:adverse effects* / Q000031:analogs & derivatives
D000700:Analgesics; D011758:Pyrroles; C020549:zomepirac; D014046:Tolmetin; D001241:Aspirin