Activity of human growth hormone and related polypeptides on the adipose conversion of 3T3 cells.
A culture system is described for the study of cellular responsiveness to growth hormone. The hormone acts directly on an established line of preadipose 3T3 cells and promotes their differentiation into adipose cells. This response is the basis of a sensitive and specific assay and does not depend on the participation of an intermediate effector.
D000273:Adipose Tissue / Q000166:cytology* / Q000187:drug effects; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D013006:Growth Hormone / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D010455:Peptides / Q000494:pharmacology*
D010455:Peptides; D013006:Growth Hormone