Effects of carbamazepine on interictal psychopathology in TLE with ictal fear.
Significant interictal psychopathology was manifested by a patient with temporal lobe epilepsy (TLE) who experienced an aura of intense fear. She was found to be taking a subtherapeutic dosage of carbamazepine; induction of therapeutic blood levels of carbamazepine resulted in improvement in the interictal EEG, decreased duration and intensity of affect during the epileptic attacks, and a normalization of behavioral and emotional functioning during the interictal period.
D000293:Adolescent; D002220:Carbamazepine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy / Q000523:psychology*; D005239:Fear / Q000187:drug effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008950:MMPI; D013997:Time Factors
D002220:Carbamazepine