Formation of a vasopressor substance in the incubated serum of patients with various hypertensive diseases.
A vasoactive substance was produced in serum when incubated at 37 degrees C. This substance differed from other known vasoactive agents. It was a phospholipid and caused an elevation in blood pressure by its direct vasoconstriction. This pressor substance increased in the incubated sera of patients with essential hypertension and in spontaneously hypertensive rats. But it was significantly low in humans and dogs in anephric states. These results suggest that the pressor substance participates in the pressor mechanism of essential hypertension and its production is closely related to the kidney.
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D001013:Aorta, Thoracic / Q000187:drug effects; D001681:Biological Assay; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007700:Kinetics; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014662:Vasoconstrictor Agents / Q000097:blood* / Q000302:isolation & purification / Q000494:pharmacology
D000959:Antihypertensive Agents; D014662:Vasoconstrictor Agents; D000804:Angiotensin II