[The effect of the injection of water-soluble triiodized monomer contrast media for intravenous urography on glomerular filtration, uricemia and urinary elimination of uric acid in normal subjects].
One mechanism suggested as being the cause of nephrotoxicity following the administration of triiodized contrast media is intratubular urate precipitation. Thirty healthy volunteers were investigated by IVU using three different media. The iodized injections (0,56 g/kg) failed to produce significant modifications of glomerular filtration and were followed by only very moderate variations in blood and urine uric acid levels.
D003287:Contrast Media; D003404:Creatinine / Q000652:urine; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007483:Iothalamic Acid; D008297:Male; D014527:Uric Acid / Q000378:metabolism*; D014567:Urography
D003287:Contrast Media; D003973:Diatrizoate; D007483:Iothalamic Acid; D014527:Uric Acid; D003974:Diatrizoate Meglumine; D003404:Creatinine
Effets de l'injection de produits de contraste triiodés hydrosolubles monomères pour l'urographie intraveineuse. L'uricémie et l'élimination urinaire sur la filtration glomérulaire de l'acide urique chez le sujet normal.