Comparison of the effects of prizidilol and propranolol on renal haemodynamics at rest and during exercise.
Effective renal plasma flow and glomerular filtration rate were measured in 22 mild-to-moderate, uncomplicated, essential hypertensive patients during placebo and after 3 months of randomly assigned treatment either with prizidilol (n = 10) or propranolol (n = 12). Measurements were performed at rest and during cycloergometer exercise. For a comparable effect on blood pressure effective renal plasma flow was significantly increased at rest by prizidilol (+9%) and decreased by propranolol (-13.6%); these patterns were maintained during exercise. Glomerular filtration rate was immodified after the treatment with both drugs. It is concluded that prizidilol is an effective hypotensive agent with no deleterious effects on renal haemodynamics.
D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D005082:Physical Exertion; D011433:Propranolol / Q000494:pharmacology*; D011724:Pyridazines / Q000494:pharmacology*; D012079:Renal Circulation / Q000187:drug effects*
D000959:Antihypertensive Agents; D011724:Pyridazines; D011433:Propranolol; C024293:prizidilol