Thiopronine-induced pemphigus vulgaris in rheumatoid arthritis.
Thiopronine, a D-penicillamine-like agent, is being prescribed increasingly for RA. Among side effects, only benign skin reactions have been mentioned to date. A single case of pemphigus erythematosus induced by this drug was recently reported. We describe here 3 other patients who developed pemphigus vulgaris during long-term thiopronine therapy and who improved after the drug was stopped.
D000368:Aged; D000603:Amino Acids, Sulfur / Q000009:adverse effects*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010392:Pemphigus / Q000139:chemically induced*; D008625:Tiopronin / Q000009:adverse effects*
D000603:Amino Acids, Sulfur; D008625:Tiopronin