Erythrocyte 2,3-diphosphoglycerate, PO250%, and available oxygen in young rabbits with and without postnatal fall in hemoglobin.
We determined erythrocyte 2,3-diphosphoglycerate (2,3-DPG), PO250%, whole blood hemoglobin concentration, and available O2 from the 12th to the 30th d after birth in two matched groups of young rabbits. One group received iron parenterally on the 12th, 15th, and 18th d and the other received no iron supplement. In the untreated group there was a marked fall in hemoglobin concentration from the 12th to the 22nd d and thereafter a marked increase to the initial level on the 30th d whereas the iron-treated animals showed a marked rise in hemoglobin concentration from the 12th to the 22nd d, and a subsequent, slight decline from the 22nd to the 30th d. The average values of PO250% and 2,3-DPG, and the changes in PO250% and 2,3-DPG were virtually identical for both groups. During the first period (12-22 d) there was a marked rise in both 2,3-DPG and PO250% whereas in the second period (22-30 d) there was a somewhat smaller rise in 2,3-DPG and only a slight tendency toward a further rise in PO250%. In the untreated animals "available O2," reflecting the O2 delivery capacity of the blood, remained unchanged during the period of fall in hemoglobin concentration and showed a rise during the second period. In the iron-treated animals "available O2" rose markedly during the first period, with iron-treatment, and remained unchanged during the second period. We conclude that the marked postnatal rise in 2,3-DPG and PO250% in the rabbit seems to be independent of the changes in the hemoglobin concentration.
D019794:2,3-Diphosphoglycerate; D000375:Aging; D000747:Anemia, Hypochromic / Q000097:blood / Q000517:prevention & control; D000818:Animals; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004909:Erythrocyte Indices; D004912:Erythrocytes / Q000378:metabolism*; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism*; D007273:Injections, Intramuscular; D007501:Iron / Q000008:administration & dosage / Q000097:blood; D010100:Oxygen / Q000097:blood*; D011817:Rabbits
D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D019794:2,3-Diphosphoglycerate; D007501:Iron; D010100:Oxygen