Effects of sulindac on myeloid precursors growth in vitro.
We have studied the effects of sulindac and its main active metabolites on human bone marrow progenitors. Granulocytic-macrophagic colony forming units (CFU-GM) techniques were used for assessment. As in vitro inhibitory action of this drug or its metabolites on CFU-GM growth could not be demonstrated. These results refute the clinically presumed toxicity of sulindac on human bone marrow progenitors at pharmacological doses.
D001853:Bone Marrow / Q000187:drug effects*; D001854:Bone Marrow Cells; D003114:Colony-Forming Units Assay; D006098:Granulocytes / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006801:Humans; D007192:Indenes / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects; D013467:Sulindac / Q000494:pharmacology*
D007192:Indenes; D013467:Sulindac