[Hemoglobin dissociation curve and 2,3-diphosphoglycerate in erythrocytes in septic shock].
The oxyhaemoglobin dissociation curve (OHDC) and intraerythrocytic 2,3-diphosphoglycerate (2,3-DPG) play an important role in oxygen delivery, especially during shock. 62 determinations in eight septic shocks were carried out. Hem.O. Scan drew the OHDC at standard temperature and PCO2; P50 was modified for pH 7.40 (P50 std) by algorithm. When the patients had recovered from the shock, their average P50 std was higher than during the shock (p less than 0.02), and much more so than in normal subjects (p less than 0.01). There was a positive correlation between P50 std and 2,3-DPG, arterial blood pH, haemoglobin and cardiac index, as well as between 2,3-DPG and arterial blood pH. On the other hand, there existed no correlation between P50 std or 2,3-DPG, and Pao2, Paco2 and phosphoremia. The Hill number was normal.
D019794:2,3-Diphosphoglycerate; D000328:Adult; D000368:Aged; D000418:Albumins / Q000008:administration & dosage; D001803:Blood Transfusion; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010108:Oxyhemoglobins / Q000378:metabolism*; D010313:Partial Pressure; D011446:Prospective Studies; D012772:Shock, Septic / Q000097:blood* / Q000503:physiopathology
D000418:Albumins; D004163:Diphosphoglyceric Acids; D010108:Oxyhemoglobins; D019794:2,3-Diphosphoglycerate; D010100:Oxygen
Courbe de dissociation de l'hémoglobine et 2,3-diphosphoglycérate intraérythrocytaire dans le choc septique.