[Effect of different types of treatment on the levels of steroid hormone receptors in breast tumors].
The levels of estrogen, progesterone and glucocorticoid receptors were assayed in samples obtained by trepanobiopsy before surgery and in resected material following chemo- and radiation therapy of 94 patients with stage IIIa, b, and c breast cancer. The biopsy levels and distribution of receptors were shown to be in agreement with those in the resected material from patients with malignancies of the same stage who, however, did not receive preoperative combined therapy. It is inferred that breast tumor biopsies may be used to determine receptor status. Radiation therapy was found to influence the level of steroid hormone receptors, the effect being determined by dosage and after exposure period.
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000188:drug therapy / Q000503:physiopathology* / Q000532:radiotherapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D011379:Prognosis; D011960:Receptors, Estrogen / Q000032:analysis; D011965:Receptors, Glucocorticoid / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D011987:Receptors, Steroid / Q000032:analysis*; D013997:Time Factors
D011960:Receptors, Estrogen; D011965:Receptors, Glucocorticoid; D011980:Receptors, Progesterone; D011987:Receptors, Steroid
Vliianie razlichnykh vidov lecheniia na urovni retseptorov steroidnykh gormonov v opukholiakh molochnoĭ zhelezy.