Recurrence of rheumatic fever during prophylaxis with monthly benzathine penicillin G.
A 9-year-old girl had apparent recurrence of rheumatic fever while receiving monthly benzathine penicillin injections. A review of pharmacokinetc studies on the subject suggests that this is a real risk. A need for review of the current recommendations for rheumatic fever prophylaxis is suggested.
D002648:Child; D005260:Female; D006801:Humans; D010401:Penicillin G Benzathine / Q000008:administration & dosage / Q000627:therapeutic use*; D010403:Penicillin Resistance / Q000187:drug effects*; D012008:Recurrence; D012213:Rheumatic Fever / Q000517:prevention & control*
D010401:Penicillin G Benzathine