Phototherapy in bile duct-ligated Gunn rats.
Davis and co-workers reported on the failure of phototherapy to reduce plasma bilirubin levels in the bile duct-ligated Gunn rat. We cannot confirm this conclusion. We found that the effect was reduced by a factor of 4-5. With higher effective irradiances distinct decreases of the serum bilirubin concentration can be achieved and the excretion of bilirubin photoproducts in the urine markedly will rise.
D000818:Animals; D001652:Bile Ducts / Q000502:physiology; D001663:Bilirubin / Q000097:blood* / Q000652:urine; D001835:Body Weight; D005260:Female; D006932:Hyperbilirubinemia / Q000378:metabolism / Q000628:therapy*; D008026:Ligation; D008954:Models, Biological; D010789:Phototherapy; D051381:Rats; D011911:Rats, Gunn
D001663:Bilirubin