[Effect of benzodiazepines on neuropathologic syndromes of spinal origin].
Comparative analysis of the effects of the drugs belonging to the same series was made in experiments on rats with generalized myoclonus and pain syndrome of spinal origin. The syndromes were produced by creating the generator of pathologically enhanced excitation in ventral and dorsal horns of the spinal cord. Phenazepam and clonazepam were found to be the most effective drugs for both forms of pathological conditions. They produced a marked anticonvulsant effect in myoclonus and analgetic effects in pain syndrome.
D000818:Animals; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000627:therapeutic use*; D002998:Clonazepam / Q000627:therapeutic use; D003975:Diazepam / Q000627:therapeutic use; D009207:Myoclonus / Q000188:drug therapy*; D010146:Pain / Q000188:drug therapy*; D051381:Rats; D013118:Spinal Cord Diseases / Q000188:drug therapy*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D001569:Benzodiazepines; C017928:phenazepam; D002998:Clonazepam; D003975:Diazepam
Vliianie benzodiazepinov na neĭropatologicheskie sindromy spinal'nogo proiskhozhdeniia.