Influence of retinoic acid on protein synthesis and transport of L-methionine in cultured L cells.
The effects of retinoic acid (RA) on cell proliferation, activity of acid phosphatase, protein synthesis and methionine uptake were studied in transformed murine LPA cells. Early inhibition of protein synthesis was demonstrated under experimental conditions in which the rate of cell proliferation was diminished and non-specific effects of vitamin action could be excluded. Measurements of L-methionine uptake revealed a decrease to approximately one-half of that in control cultures after treatment with RA at the concentrations of 5 X 10(-5) M and 10(-4) M.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002471:Cell Transformation, Neoplastic; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D007739:L Cells; D008715:Methionine / Q000378:metabolism*; D051379:Mice; D014176:Protein Biosynthesis; D014212:Tretinoin / Q000494:pharmacology*
D014212:Tretinoin; D008715:Methionine; D000135:Acid Phosphatase