[Changes in the electrolyte balance and the transmural differential in the potentials of the blood vessel wall during the administration of spironolactone and its combination with euphylline].
It has been demonstrated in experiments on normotensive cats that during chronic administration of spironolactone alone or combined with euphylline there occur inconclusive variations in the transmural potential difference and electrolyte balance in the vascular wall. Spironolactone did not produce any marked changes in electrolyte balance and hypotensive effect. Combined administration of the drugs under study made the intima of the carotid artery electrically positive. By day 5 one can see a clear tendency to an increase in the biopotential towards electric negative, with the alterations in the sodium and potassium content in the vascular wall being the most pronounced.
D000628:Aminophylline / Q000008:administration & dosage*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects* / Q000378:metabolism; D002415:Cats; D004573:Electrolytes / Q000378:metabolism; D005260:Female; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects; D013148:Spironolactone / Q000008:administration & dosage*; D013997:Time Factors; D014882:Water-Electrolyte Balance / Q000187:drug effects*
D004573:Electrolytes; D013148:Spironolactone; D000628:Aminophylline
Izmenenie élektrolitnogo balansa i chresstenochnoĭ raznosti potentsialov stenki krovenosnykh sosudov pri naznachenii spironolaktona i ego kombinatsii s éufillinom.