[Effect of Fe2+- and gamma-induced lipid peroxidation on respiration and oxidative phosphorylation in the mitochondria].
Lipid peroxidation activated by low concentrations of Fe2+ ions in a medium (1-5 microM) and gamma-quanta (10-50 Gy) stimulates the oxygen consumption and oxidative phosphorylation during the initial period of incubation (10-20 min). With relatively high concentrations of Fe2+ ions and higher radiation doses (50-100 Gy) inhibition of the activity of mitochondria is registered with respect to both indices.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005296:Ferrous Compounds / Q000494:pharmacology*; D005720:Gamma Rays; D066298:In Vitro Techniques; D007501:Iron / Q000494:pharmacology*; D008054:Lipid Peroxides / Q000378:metabolism / Q000528:radiation effects*; D051379:Mice; D008808:Mice, Inbred CBA; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects*; D010085:Oxidative Phosphorylation / Q000187:drug effects / Q000528:radiation effects*; D010101:Oxygen Consumption / Q000187:drug effects / Q000528:radiation effects*
D005296:Ferrous Compounds; D008054:Lipid Peroxides; D007501:Iron; C029451:ferrous chloride
Vliianie Fe2 - i gamma-indutsirovannogo perekisnogo okisleniia lipidov na dykhanie i okislitel'noe fosforilirovanie v mitokhondriiakh.