title: Selective transport of serum-derived IgA into mucosal secretions.
abstract: The relative contribution of serum-derived and locally produced IgA has been estimated in sheep mammary secretion at various stages of lactation by comparing the transport of radiolabeled IgA and IgG2 from serum to secretions. During early and mid-lactation, but not during involution, serum IgA was selectively transported to mammary secretion on a large scale; in comparison, there was no transport of serum IgA into intestinal secretion. Estimates of local production indicated that the bulk of the IgA in mammary involution secretion and intestinal secretion was locally produced, whereas there was no evidence for local production of IgA in early or mid-lactation secretion. Our studies reveal an inverse relationship between the extent of local production of IgA by plasma cells underlying secretory epithelia and the selective transport of IgA from serum. This finding suggests that selective transport of serum IgA occurs at a number of mucosal sites, but is dependent on secretory component availability, because where local production is predominant, there are fewer secretory component molecules available for serum IgA transport. For this reason, bile transport of IgA does not represent a unique mechanism for the removal of IgA from serum.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D001692:Biological Transport; D005260:Female; D007070:Immunoglobulin A / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism*; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000032:analysis / Q000378:metabolism; D007413:Intestinal Mucosa / Q000276:immunology / Q000378:metabolism*; D008321:Mammary Glands, Animal / Q000276:immunology / Q000378:metabolism*; D011817:Rabbits; D012756:Sheep
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G