Seronegative spondyloarthropathies and HLA antigens in a Mestizo population.
HLA-A and -B antigens incidence were investigated in 100 cases of Seronegative Spondyloarthropathies and in 303 control individuals of a Venezuelan Mestizo population. Significative increased incidence of B27 was found among 69% of patients with ankylosing spondylitis and 68% with Reiter syndrome being the incidence in the control group of 2.9%. The B27 negative patients showed 40.4% positivity for Bw35, with spondylitic lesion in 12 out of 17 cases. Our results question the applicability of B27 as diagnostic criteria in the Mestizo patients bearers of a Seronegative Spondyloarthropathy and suggest the need to investigate further the role of antigens of the B locus in the pathophysiology of these clinical entities.
D001168:Arthritis / Q000276:immunology*; D016918:Arthritis, Reactive / Q000276:immunology*; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007199:Indians, South American; D013167:Spondylitis, Ankylosing / Q000276:immunology*; D014687:Venezuela / Q000208:ethnology
D006680:HLA Antigens