Levamisole and bovine mastitis.
Levamisole is an anthelmintic drug which also has immunomodulatory properties. The application of these immunomodulatory properties in the prevention and, or, treatment of bovine mastitis is considered. In the light of the available evidence on the use of levamisole against mastitis and of our understanding of the pathogenesis of mastitis it is thought that the prospect of using levamisole beneficially is limited. However, drying-off and parturition are two times at which levamisole may have rational application in mastitis prevention.
D000818:Animals; D002417:Cattle; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D005260:Female; D017099:IgG Deficiency; D007108:Immune Tolerance / Q000187:drug effects; D007743:Labor, Obstetric; D007978:Levamisole / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D008414:Mastitis, Bovine / Q000188:drug therapy / Q000517:prevention & control*; D009504:Neutrophils / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D011247:Pregnancy
D007978:Levamisole