Plasma metabolites after 2-deoxy-D-glucose in rats with brain dopamine-depleting lesions.
Rats with selective brain dopamine-depleting lesions produced by 6-hydroxydopamine failed to increase their food intake after 2-deoxy-D-glucose administration. Their hyperglycemic response to 2DG was identical to that of intact controls. Neither group showed significant mobilization of free fatty acids or production of ketones.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001921:Brain / Q000378:metabolism*; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D004435:Eating / Q000187:drug effects; D005230:Fatty Acids, Nonesterified / Q000097:blood; D007659:Ketones / Q000097:blood; D008297:Male; D010949:Plasma / Q000032:analysis*; D051381:Rats / Q000502:physiology*
D001786:Blood Glucose; D003837:Deoxy Sugars; D005230:Fatty Acids, Nonesterified; D007659:Ketones; D003847:Deoxyglucose; D004298:Dopamine