title: Serum somatomedin A in Perthes' disease.
abstract: Serum somatomedin A, determined by radioreceptor assay in 47 children with Perthes' disease, was significantly reduced as compared to normal children of the same age. Nine children underwent the 1-Dopa tolerance tests to evoke growth hormone release; a normal response was found in eight. Patients with Perthes' disease tend to be short in stature with "disproportionate skeletal growth" of the limbs; growth is less in the distal than in the proximal extremities. The low serum levels of somatomedin A suggest some growth disturbance during the development of Perthes' disease.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005271:Femur Head Necrosis / Q000097:blood*; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007335:Insulin-Like Growth Factor II; D007564:Japan; D007873:Legg-Calve-Perthes Disease / Q000097:blood* / Q000145:classification / Q000503:physiopathology; D007980:Levodopa; D008297:Male; D011869:Radioligand Assay; D013002:Somatomedins / Q000097:blood*; D013548:Sweden
chemical_list: D013002:Somatomedins; D007980:Levodopa; D007335:Insulin-Like Growth Factor II; D013006:Growth Hormone