Effect of intravenous and intrajejunal fat infusion on gastric acid secretion and plasma neurotensin-like immunoreactivity in man.
The effects of intrajejunal and intravenous infusion of fat (100 ml Intralipid 20%) on pentagastrin-stimulated gastric acid secretion and on the concentrations of plasma neurotensin-like immunoreactivity (p-NTLI) were studied in eight healthy subjects. Gastric acid secretion was studied for a 1.5-h period at 15-min intervals after fat administration. Acid secretion was reduced by 58% and 36%, respectively, after intrajejunal and intravenous administration. The concentration of p-NTLI rose significantly from 29 to 177 pmol/l at 45 min after intrajejunal administration but did not change after intravenous infusion. The results indicate that large volumes of fat inhibit gastric acid secretion by a neurotensin-independent postabsorptive mechanism and by an intestinal mechanism that may in part be mediated by neurotensin.
D000328:Adult; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology*; D005223:Fats / Q000008:administration & dosage; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D007583:Jejunum; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000097:blood*; D009479:Neuropeptides; D010418:Pentagastrin / Q000494:pharmacology; D013997:Time Factors
D005217:Fat Emulsions, Intravenous; D005223:Fats; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; C031644:neurotensin-like immunoreactivity; D010418:Pentagastrin