Grass Conjuvac. II. Pro-inflammatory activity and potential for inducing hypersensitivity.
Treatment of rats with Conjuvac induced no anti-pollen extract (PE) IgE and no sensitization, whereas alum-adsorbed pollen extract induced IgE antibody and marked sensitivity. Conjuvac induced anti-PE IgE in rats treated with Bordetella pertussis organisms but the antibody concentrations were less than those induced by PE with B. pertussis. There was no indication, either in rats injected with B. pertussis and Conjuvac or alginate (ALG), of sensitization to ALG. In guinea pigs, Conjuvac induced immediate hypersensitivity to PE but there was no delayed hypersensitivity. Furthermore, no immediate hypersensitivity and little or no delayed hypersensitivity to ALG was detected in guinea pigs injected with conjuvac or ALG. Histological studies at Conjuvac injection sites in rabbits revealed inflammatory reactions less intense than those produced by aluminium hydroxide.
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D000961:Antilymphocyte Serum / Q000008:administration & dosage; D001169:Arthritis, Experimental / Q000209:etiology; D006023:Glycoproteins / Q000008:administration & dosage*; D006168:Guinea Pigs; D006969:Hypersensitivity, Immediate / Q000209:etiology / Q000276:immunology* / Q000473:pathology; D007114:Immunization; D007249:Inflammation / Q000209:etiology / Q000276:immunology / Q000473:pathology; D008297:Male; D011058:Pollen / Q000276:immunology; D011817:Rabbits; D051381:Rats; D011935:Reagins / Q000096:biosynthesis
D000276:Adjuvants, Immunologic; D000961:Antilymphocyte Serum; D006023:Glycoproteins; D011935:Reagins; C038866:conjuvac