Effects of Lonidamine on murine and human tumor cells in vitro. A morphological and biochemical study.
Lonidamine induces in murine and human tumor cells severe morphological damage of the mitochondria and other cytoplasmic structures both 'in vitro' and 'in vivo'. Biochemical studies have demonstrated that the drug decreases oxygen consumption and lactate production. The sensitivity of human tumor cells is not related to their histotype. Lonidamine's effects on mitochondria, glycolysis, pentose phosphate pathway, and aromatase activity are discussed.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000648:ultrastructure*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D066298:In Vitro Techniques; D007191:Indazoles / Q000494:pharmacology*; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D007942:Leukemia, Experimental / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D008928:Mitochondria / Q000187:drug effects; D009369:Neoplasms / Q000648:ultrastructure*; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D007191:Indazoles; D007773:Lactates; D011720:Pyrazoles; D019344:Lactic Acid; C016371:lonidamine