title: Skin metastases confined to a field of previous irradiation. Report of two cases and review of the literature.
abstract: Two cases of tumor recurrence within a previously irradiated skin area are reported. Typical lesions evolve from an erythematous base and progress to induration and tumor papules. A review of clinical literature indicates that irradiation does not increase the frequency of metastases. Experimental data suggest that irradiation does increase metastases as a result of both local mechanical factors and increased tumor-cell survival.
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary*; D000328:Adult; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D005260:Female; D006801:Humans; D008408:Mastectomy; D008875:Middle Aged; D011878:Radiotherapy / Q000009:adverse effects*; D012878:Skin Neoplasms / Q000473:pathology / Q000556:secondary*