Lyt phenotype and H-2 compatibility requirements of effector cells in the delayed-type hypersensitivity response to dengue virus infection.
The nature of effector cells which mediate delayed-type hypersensitivity (DTH) to dengue type 2 virus and the influence of the H-2 complex on the cellular transfer of DTH was investigated. The DTH effector cells appeared to consist of two types of T cells, one Lyt-1.1+, the other Lyt-2.1+ or, alternatively, an interaction between these two T cell subsets may be required for maximal expression of DTH. Cellular transfer of DTH reactivity also required compatibility at the K and D or I region of the H-2 complex. Compatibility at the D region alone was not sufficient for transfer of DTH. The significance and implications of these findings are discussed.
D000483:Alleles; D000818:Animals; D003715:Dengue / Q000276:immunology*; D003716:Dengue Virus / Q000276:immunology*; D006183:H-2 Antigens / Q000235:genetics*; D006968:Hypersensitivity, Delayed; D007116:Immunization, Passive; D007518:Isoantibodies / Q000235:genetics*; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D013045:Species Specificity
D006183:H-2 Antigens; D007518:Isoantibodies; C029805:Lyt antibodies