Carboxyphenyl chloroanthranilic acid (CCA) in the modulation of immune response in mice.
A study to elucidate the immunopharmacological mechanisms of carboxyphenyl chloroanthranilic acid (CCA) was carried out, employing as a parameter the rosette formation of mouse spleen and thymus cells with red blood cells of sheep. The immunopharmacological properties of CCA and levamisole (LMS) were compared. In C57BL/6 mice, the immune response was either suppressed or enhanced by LMS, whereas CCA caused a suppression of rosette formation. Both drugs enhanced response in adult thymectomized C57BL/6 mice. LMS induced Thy-1 positive rosette-forming cells after adult thymectomy in C57BL/6 mice, whereas CCA did not. CCA was significantly effective in restoring the impaired immune response in C57BL/6 mice pretreated with immunosuppressants. The effect of LMS or CCA on the immune response varied among six different mouse strains (C57BL/6, BALB/c, C3H/He, DBA/2, (NZB X NZW) F1 and BXSB). The results suggest that both drugs have immunomodulation or immunonormalization properties.
D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D007978:Levamisole / Q000008:administration & dosage / Q000494:pharmacology*; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000276:immunology*; D012397:Rosette Formation; D013154:Spleen / Q000276:immunology; D013950:Thymus Gland / Q000276:immunology; D062367:ortho-Aminobenzoates / Q000008:administration & dosage / Q000494:pharmacology*
D062367:ortho-Aminobenzoates; D007978:Levamisole; C015735:lobenzarit