Neutrophil chemotactic activity and histamine in atopic and nonatopic subjects after exercise-induced asthma.
Seven atopic and 6 nonatopic asthmatics with exercise-induced asthma were subjected to a treadmill exercise task. After this procedure, both groups had elevations in the concentrations of plasma histamine and serum high molecular weight neutrophil chemotactic activity (as assessed by Sephadex G-200 chromatography). These findings support the view that the release of mast-cell-associated mediators can be independent of the atopic state.
D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000276:immunology*; D001250:Asthma, Exercise-Induced / Q000276:immunology* / Q000503:physiopathology; D002634:Chemotaxis, Leukocyte; D002850:Chromatography, Gel; D005260:Female; D006632:Histamine / Q000097:blood*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology* / Q000503:physiopathology; D007073:Immunoglobulin E / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D010366:Peak Expiratory Flow Rate; D013997:Time Factors
D007073:Immunoglobulin E; D006632:Histamine