title: Effects of dietary sucrose on factors influencing cholesterol gall stone formation.
abstract: Twelve subjects with radiolucent gall stones and bile supersaturated with cholesterol were studied after six weeks each on diets which contained 112 g and 16 g respectively of refined (fibre depleted) sucrose but which allowed free access to other foods. Energy intake was 24.5% higher on the high sugar diet and body weight ended 1.4 kg higher than on the low sugar diet. Biliary secretion rates of cholesterol, phospholipid and bile acid, measured by a perfusion technique, were similar on the two diets, as were the bile acid pool sizes measured by isotope dilution. Cholesterol saturation index of fasting 'gall bladder' bile was 1.30 +/- 0.11 and 1.37 +/- 0.14 on high and low sugar respectively (NS). Plasma triglycerides were 36% higher and plasma high density lipoprotein cholesterol concentrations were 9% lower on the high sugar diet. These findings indicate that over a six week period refined sugar in normally consumed amounts does not adversely affect the lipid composition of bile.
mesh_terms: D000328:Adult; D000368:Aged; D001647:Bile Acids and Salts / Q000378:metabolism; D001835:Body Weight; D002769:Cholelithiasis / Q000209:etiology / Q000378:metabolism*; D002784:Cholesterol / Q000378:metabolism*; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010743:Phospholipids / Q000378:metabolism; D012636:Secretory Rate; D013395:Sucrose / Q000008:administration & dosage*; D014280:Triglycerides / Q000378:metabolism
chemical_list: D001647:Bile Acids and Salts; D004040:Dietary Carbohydrates; D010743:Phospholipids; D014280:Triglycerides; D013395:Sucrose; D002784:Cholesterol