[Developmental characteristics of the inferior tracheobronchial and mesenteric lymph nodes in exposure to tetracycline hydrochloride].
Development of the tracheobronchial and mesenteric lymph nodes has been studied in fetuses and offsprings of Wistar rats after an intramuscular administration to the female rats therapeutic doses of tetracycline hydrochloride during the first 6 days of pregnancy (preimplantation period of embryogenesis). General histological and morphometrical methods have been applied. Under the experimental conditions certain disorders in formation of functional structures of the lymph nodes have been revealed: differentiation of the parenchyma into the cortical and medullary substance formation of follicles and their germinative centers, development of sinuses, formation of argyrophile stroma architectonics are delayed. Some distrophic and destructive changes of the reticular cells are observed, argyrophilia of the reticular fibers is more evident. Lympho- and plasmocytosis are retarded on the background of an increased eosinophilic and mast cell reaction.
D000375:Aging / Q000187:drug effects; D000818:Animals; D000831:Animals, Newborn; D001980:Bronchi; D047108:Embryonic Development / Q000187:drug effects; D005260:Female; D005865:Gestational Age; D008198:Lymph Nodes / Q000187:drug effects* / Q000196:embryology / Q000254:growth & development; D008643:Mesentery; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D013752:Tetracycline / Q000494:pharmacology*; D014132:Trachea
D013752:Tetracycline
Osobennosti razvitiia nizhnikh trakheobronkhial'nykh i bryzheechnykh limfaticheskikh uzlov pri vozdeĭstvii tetratsklina gidrokhlorida.