[Effect of combined use of hyperbaric oxygenation and alpha-tocopherol on the contractile function and various components of the antioxidant system of the heart after adrenaline lesioning].
A session of hyperbaric oxygenation (HBO) at 2.5 at. abs. conducted for one hour in rabbits with adrenalin heart affection (AHA) immediately after adrenalin administration prevented a decrease in the cardiac contractile function usually developing within two hours after AHA. On the third day of the follow up, rabbits with AHA receiving daily HBO displayed a decrease in the pump and contractile functions as well as in superoxide dismutase (SOD) activity and the antioxidant activity (AOA) of the left ventricle lipids. Combination of HBO sessions with the intra-muscular administration of alpha-tocopherol (50 mg/kg) made the decrease in SOD activity less pronounced and prevented both the fall in lipid AOA and the depression of the heart contractile and pump functions on the third day following AHA. It is suggested that the combined use of HBO and substances increasing the potency of the cell antioxidation system may become one of the principles of reducing HBO side effects and of expanding the potentialities of HBO in treating ischemic and adrenergic heart impairments.
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000628:therapy; D002682:Chinchilla; D003131:Combined Modality Therapy; D003327:Coronary Disease / Q000628:therapy*; D004837:Epinephrine; D006931:Hyperbaric Oxygenation; D009206:Myocardium / Q000378:metabolism*; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use*
D014810:Vitamin E; D004837:Epinephrine
Vliianie sovmestnogo ispol'zovaniia giperbaricheskoĭ oksigenatsii i alpha-tokoferola na sokratitel'nuiu funktsiiu i nekotorye komponenty antiokislitel'noĭ sistemy serdtsa pri ego adrenalinovom povrezhdenii.