Effects of benfluorex and fenofibrate treatment on mitochondrial and peroxisomal marker enzymes in rat liver.
Our results demonstrate that benfluorex at doses that are strongly hypotriglyceridemic does not increase hepatic peroxisomal enzyme activities, whereas fenofibrate at doses that are only slightly hypolipidemic induces a dramatic increase in the activity of these enzymes. Thus, the biochemical approach used in this study reveals that the hypolipidemic drug benfluorex does not belong to the class of hypolipidemic compounds known to induce hepatomegaly, hepatic peroxisome proliferation and hepatocarcinoma in rodents. Morphological studies should confirm the absence of peroxisomal induction.
D000818:Animals; D002374:Catalase / Q000032:analysis; D005277:Fenfluramine / Q000031:analogs & derivatives* / Q000633:toxicity; D011345:Fenofibrate / Q000031:analogs & derivatives / Q000633:toxicity*; D005969:Glutamate Dehydrogenase / Q000032:analysis; D000960:Hypolipidemic Agents / Q000633:toxicity*; D008099:Liver / Q000187:drug effects*; D008297:Male; D008830:Microbodies / Q000187:drug effects* / Q000201:enzymology; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000201:enzymology; D011422:Propionates / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains
D000960:Hypolipidemic Agents; D011422:Propionates; D005277:Fenfluramine; C001584:benfluorex; C006012:fenofibric acid; D002374:Catalase; D005969:Glutamate Dehydrogenase; D011345:Fenofibrate