Glycerol effects on the transport of macromolecules in the lateral cochlear wall. An HRP study in the guinea pig.
The effect has been studied of intravenously administered glycerol on paracellular and cellular transport of macromolecular HRP tracer in the lateral cochlear wall. The findings indicate osmotically induced diffusion phenomena by the opening of shunt pathways through junctional complexes in the stria vascularis. Vesicular transport is accelerated, direction of transport however is not affected by the changed osmolality.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003051:Cochlea / Q000187:drug effects*; D005990:Glycerol / Q000494:pharmacology*; D006168:Guinea Pigs; D006735:Horseradish Peroxidase / Q000378:metabolism; D046911:Macromolecular Substances; D009994:Osmolar Concentration; D013316:Stria Vascularis / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure
D046911:Macromolecular Substances; D006735:Horseradish Peroxidase; D005990:Glycerol