Functionalized polymeric liposomes. Efficient immobilization of alpha chymotrypsin.
A polymerizable phospholipid has been synthesized having a latent aldehyde moiety in the head group (1). Photopolymerized vesicles which have been prepared from this phosphatidylcholine have been successfully conjugated to alpha chymotrypsin. A high degree of loading was achieved with significant retention of enzymatic function.
D002918:Chymotrypsin / Q000378:metabolism*; D004800:Enzymes, Immobilized / Q000378:metabolism*; D008081:Liposomes; D009682:Magnetic Resonance Spectroscopy; D010713:Phosphatidylcholines / Q000138:chemical synthesis; D013055:Spectrophotometry, Infrared
D004800:Enzymes, Immobilized; D008081:Liposomes; D010713:Phosphatidylcholines; D002918:Chymotrypsin