title: The treatment of Kaposi's sarcoma by combination chemotherapy in Nigeria.
abstract: Kaposi's sarcoma is known to be multicentric in origin. It starts predominantly on the skin but visceral organs can be involved as well. Previous experience in the management of this condition in Lagos, Nigeria has been based mainly on the use of local radiotherapy. A better understanding of the natural history and clinicopathological features of this disease has given prominence to the use of chemotherapy and this is now being advocated as the first line of management in most cases in place of radiotherapy. Experience and results of the use of multiple chemotherapy in 10 cases seen at the Lagos University Teaching Hospital between 1976 and 1982 are discussed. Seven patients (70%) showed complete tumour regression, two (20%) had partial response and one (10%) did not respond.
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012514:Sarcoma, Kaposi / Q000188:drug therapy*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D003609:Dactinomycin; D014750:Vincristine; D003520:Cyclophosphamide