title: Metabolism of arsenocholine in mice, rats and rabbits.
abstract: The distribution, retention and biotransformation of arsenocholine, an organic arsenic compound present in certain seafood, have been studied in rats, mice and rabbits by use of synthesized 73 As-labelled arsenocholine. Orally administered arsenocholine was almost completely absorbed from the gastro-intestinal tract in mice and rats. In all species 70--80% of the administered dose was excreted in the urine within 3 days, [73 As] arsenobetaine was the main urinary metabolite; [73 As] arsenocholine was found in the urine of the first day only. No degradation to inorganic arsenic, mono- or dimethylarsenic acids, or trimethylarsine oxide was observed. In the tissues the 73 As activity retained was found in the form of [73 As] arsenobetaine and [73 As arsenophospholipids. Tissues with longest retention times were prostate, epididymis, testes, myocardium, liver, adrenal cortex, pancreas, dental pulp and pituitary gland.
mesh_terms: D000818:Animals; D001151:Arsenic / Q000378:metabolism* / Q000652:urine; D001152:Arsenicals / Q000008:administration & dosage / Q000378:metabolism*; D001711:Biotransformation; D005243:Feces / Q000032:analysis; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D010743:Phospholipids / Q000378:metabolism; D011817:Rabbits; D011868:Radioisotopes; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
chemical_list: D001152:Arsenicals; D010743:Phospholipids; D011868:Radioisotopes; C039920:arsenocholine; D001151:Arsenic; C038992:arsenobetaine