[Comparative study of dioxidine and quinoxidine in a chronic toxicology experiment].
The toxicity of dioxydin and quinoxidine was studied in experiments on rats and mice given the drugs intravenously. The target organs for both drugs are the adrenals. The pathological process develops in their cortical layer and continues progressing after the drugs are discontinued. Quinoxidine appeared less toxic owing to which the pathological signs in the adrenals were reversible in the majority of animals given this drug in a dose of 100 mg/kg.
D000311:Adrenal Glands / Q000187:drug effects / Q000473:pathology; D000818:Animals; D000890:Anti-Infective Agents / Q000633:toxicity*; D001769:Blood / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D011810:Quinoxalines / Q000633:toxicity*; D051381:Rats; D013997:Time Factors
D000890:Anti-Infective Agents; D011810:Quinoxalines; C003286:quinoxidine; C001077:dioxidine
Sravnitel'noe izuchenie dioksidina i khinoksidina v khronicheskom toksikologicheskom éksperimente.