Phase II enzyme induction reduces body burden of heptachlor in rats.
Contrary to expectations hexadecane had no significant effect on the body clearance of heptachlor in rats. However, phase II enzyme induction altered the kinetics of heptachlor dramatically, reducing its half-life by about 3-fold. The reduction of half-life was reflected in correspondingly lowered adipose tissue and blood levels.
D000473:Alkanes / Q000494:pharmacology; D000818:Animals; D001646:Bile / Q000378:metabolism; D001822:Body Burden; D004790:Enzyme Induction; D005243:Feces / Q000032:analysis; D006207:Half-Life; D006533:Heptachlor / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000473:Alkanes; D006533:Heptachlor; C007932:n-hexadecane