Effects of 5-halopyrimidinones with antiviral and antineoplastic activity on murine cytochrome P-450.
Several 5-halopyrimidinones have been shown to have many different biological activities. These include interferon induction, antitumor effects, modulation of immune responses, and polyclonal B-cell activation. The present study was carried out to determine the effects of treatment of mice with two 5-halopyrimidinones, 2-amino-5-bromo-6-phenyl-4(3H)-pyrimidinone (ABPP) and 2-amino-5-iodo-6-phenyl-4(3H)-pyrimidinone (AIPP), on the murine cytochrome P-450 system. Administration of ABPP or AIPP to mice by a dosage regimen similar to that resulting in interferon induction by these chemicals resulted in a significant depression in liver cytochrome P-450 levels. These results suggest that 5-halopyrimidinones can depress cytochrome P-450 levels and that this depression may affect the metabolism of other drugs by cytochrome P-450.
D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D003596:Cytosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology
C033561:2-amino-5-iodo-6-phenyl-4-pyrimidinone; D003596:Cytosine; D003577:Cytochrome P-450 Enzyme System; C033560:bropirimine