Inactivation of betaine-homocysteine methyltransferase by adenosylmethionine and adenosylethionine.
Preincubation of betaine-homocysteine methyltransferase, prepared from rat liver, with either S-adenosylmethionine or S-adenosylethionine results in a marked loss of enzyme activity. Gel filtration did not restore activity. However both S-adenosylhomocysteine and L-homocysteine, when added to the preincubation medium, inhibited the inactivation of betaine-homocysteine methyltransferase.
D000241:Adenosine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D050940:Betaine-Homocysteine S-Methyltransferase; D002850:Chromatography, Gel; D005001:Ethionine / Q000031:analogs & derivatives* / Q000494:pharmacology; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D008780:Methyltransferases / Q000037:antagonists & inhibitors*; D051381:Rats; D012436:S-Adenosylmethionine / Q000494:pharmacology*; D013329:Structure-Activity Relationship
C012167:S-adenosylethionine; D012436:S-Adenosylmethionine; D008780:Methyltransferases; D050940:Betaine-Homocysteine S-Methyltransferase; C494550:Bhmt protein, rat; D000241:Adenosine; D005001:Ethionine