Reduction of digoxin effect during the digoxin-quinidine interaction.
The effects of the digoxin-quinidine interaction on cardiac function was examined in healthy subjects. Our results indicate that while serum digoxin levels were elevated, the improved cardiac function due to digoxin declined during combined therapy. Our data also provide an alternate explanation for the changes previously interpreted as "enhanced digitalis effects" during the interaction.
D000328:Adult; D004077:Digoxin / Q000097:blood / Q000494:pharmacology*; D004347:Drug Interactions; D004562:Electrocardiography; D004594:Electrophysiology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D011802:Quinidine / Q000494:pharmacology*
D004077:Digoxin; D011802:Quinidine