Coronary arteries of cardiac patients are hyperreactive and contain stores of amines: a mechanism for coronary spasm.
Coronary arteries from hearts of cardiac patients contain significantly higher concentrations of histamine than do those from noncardiac patients. The coronary vessels of cardiac patients are also hyperresponsive to histamine and serotonin. These differences between groups of patients suggest an explanation for coronary artery spasm in heart disease.
D000328:Adult; D000368:Aged; D000818:Animals; D001161:Arteriosclerosis / Q000503:physiopathology; D002395:Catecholamines / Q000032:analysis; D002417:Cattle; D003329:Coronary Vasospasm / Q000503:physiopathology*; D003331:Coronary Vessels / Q000032:analysis / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D006632:Histamine / Q000032:analysis* / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000494:pharmacology; D012701:Serotonin / Q000032:analysis / Q000494:pharmacology
D002395:Catecholamines; D012701:Serotonin; D006632:Histamine; D009638:Norepinephrine