A kinetic and clonal analysis of heterogeneity in K562 cells.
Expression of markers of differentiation was measured in a clone of the continuous cell line K562, derived originally from the cells of a patient with leukemia. Three of the markers were lineage specific, R18 for erythropoiesis and 80H.5 and My-1 for granulopoiesis. The fourth marker was the self-renewal capacity of clonogenic cells. The markers were measured as a function of time in pooled colonies from day 2 to day 12, and at a point of time in individual colonies. Evidence of an orderly pattern of marker appearance and disappearance was not seen. Rather, their expression appeared to occur at random during growth.
D002454:Cell Differentiation; D002455:Cell Division; D002460:Cell Line; D002999:Clone Cells / Q000473:pathology; D004920:Erythropoiesis; D006410:Hematopoiesis; D006801:Humans; D007938:Leukemia / Q000473:pathology*