title: Cells of origin of the ventral cholinergic septohippocampal pathway undergoing compensatory collateral sprouting following fimbria-fornix transection.
abstract: The axons of the septohippocampal pathway reach the hippocampal formation via the fimbria, dorsal fornix and supracallosal striae. Complete lesions of these pathways denervate most of the hippocampal formation but a small, residual innervation occurs via a different ventral route. The cells of origin for this additional route for cholinergic innervation of the hippocampal formation have been identified in the present study with a combined technique using a fluorescent retrograde tracer and acetylcholinesterase histochemistry. These cells were localized to the diagonal band of Broca. In a subsequent experiment it was demonstrated, by destroying these cells unilaterally, that they were responsible to a large extent for the cholinergic compensatory collateral sprouting in the hippocampus that has previously been shown to develop following complete fimbria-fornix transection.
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D002799:Cholinergic Fibers / Q000648:ultrastructure*; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D006179:Gyrus Cinguli / Q000033:anatomy & histology; D006624:Hippocampus / Q000033:anatomy & histology*; D007031:Hypothalamus / Q000033:anatomy & histology*; D007034:Hypothalamus, Posterior / Q000033:anatomy & histology*; D008856:Microscopy, Fluorescence; D009416:Nerve Regeneration; D009434:Neural Pathways / Q000033:anatomy & histology; D009474:Neurons / Q000648:ultrastructure; D051381:Rats; D012688:Septum Pellucidum / Q000033:anatomy & histology*
chemical_list: D000110:Acetylcholinesterase