[Evaluation of a delayed-action beta blocker by 24-hour ambulatory recording of the arterial pressure].
Twelve students aged 21 to 39 years (mean age 26) with borderline hypertension underwent three 24 hours ambulatory recordings of blood pressure using an Avionics Pressurometer II device: the first recording under basic conditions, the second after taking placebo and the third after being treated for 3 days with a betablocker of long acting effect (oxprenolol R 160 mg) in a randomized study. The blood pressure mean profile showed a double peak during daily activity with a progressive lowering of the blood pressure during sleep. The effect on the blood pressure of long acting oxprenolol begins four hours later, remains for about ten hours and may be still present next day. The shape of the circadian blood pressure profile is not modified. No significant difference between the pressure profiles on the basic conditions and placebo is noticed.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination / Q000379:methods; D003692:Delayed-Action Preparations; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D010096:Oxprenolol / Q000008:administration & dosage*; D011897:Random Allocation
D003692:Delayed-Action Preparations; D010096:Oxprenolol
L'évaluation de l'effet d'un beta-bloqueur retard par l'enregistrement ambulatoire de 24 heures de la pression artérielle.