title: Concentrations of vancomycin in bone and serum of normal rabbits and those with osteomyelitis.
abstract: The concentrations of vancomycin in the bone and serum of rabbits with Staphylococcus aureus osteomyelitis were assessed after each rabbit was given a single dose of vancomycin. Simultaneous mean concentrations of vancomycin in infected rabbits 1 h after administration of the antibiotic were 36.4 +/- 4.6 micrograms/ml (serum), 5.3 +/- 0.8 microgram/g (infected bone), and 3.0 +/- 0.2 micrograms/g (noninfected bone). Concentrations of vancomycin in serum of normal controls were higher than concentrations of vancomycin in serum of osteomyelitic rabbits after 1, 2, 3, and 6 h.
mesh_terms: D000818:Animals; D001842:Bone and Bones / Q000378:metabolism*; D010019:Osteomyelitis / Q000378:metabolism*; D011817:Rabbits; D013203:Staphylococcal Infections / Q000378:metabolism*; D014640:Vancomycin / Q000097:blood / Q000378:metabolism*
chemical_list: D014640:Vancomycin