Chemotherapy-increased antineoplastic effects of antibody-toxin conjugates.
A model, employing murine L1210 leukemia to which the artificial determinant TNP was bound in vitro and an anti-DNP antibody-ricin A-chain conjugate, was used to explore the in vivo therapeutic potential of combined immunotoxin-chemotherapy treatment. Under conditions in which immunotoxin and chemotherapy as single therapies had only marginal therapeutic activity, their combined use was markedly effective.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology*; D002460:Cell Line; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004317:Doxorubicin / Q000627:therapeutic use*; D005260:Female; D006241:Haptens / Q000276:immunology; D007167:Immunotherapy; D007939:Leukemia L1210 / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation
D000936:Antigen-Antibody Complex; D006241:Haptens; D004317:Doxorubicin; D003520:Cyclophosphamide