The effect of neurotensin on pituitary secretion of thyrotrophin and prolactin in vitro.
The effects of neurotensin on thyrotrophin (TSH) and prolactin (Prl) release were studied in two in vitro systems - anterior pituitary cells in culture and perifused anterior pituitary fragments. Neurotensin significantly reduced basal secretion of both TSH and Prl (P less than 0.001) from cultured pituitary cells, and abolished thyrotrophin releasing hormone (TRH)-stimulated TSH thyrotrophin releasing hormone (TRH)-stimulated TSH TSH and Prl release (P less than 0.02) from perifused pituitary fragments. These data indicate that neurotensin has a direct inhibitory effect on TSH and Prl secretion by the anterior pituitary.
D000818:Animals; D002478:Cells, Cultured; D005260:Female; D009496:Neurotensin / Q000494:pharmacology*; D010477:Perfusion; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013972:Thyrotropin / Q000378:metabolism*
D009496:Neurotensin; D011388:Prolactin; D013972:Thyrotropin