Distribution of tin in brain subcellular fractions following the administration of trimethyl tin and triethyl tin to the rat.
The time course of tin distribution in homogenates and subcellular fractions of rat brain was determined following the acute administration of trimethyl tin (TMT) and triethyl tin (TET) to the rat. Exposure to TMT resulted in lower concentrations but greater persistence of tin in subcellular fractions compared to exposure to TET. A delayed accumulation of tin in the mitochondrial fraction was observed following the administration of TMT but not TET. Analysis of total protein and mitochondrial markers did not reveal differences between the compositions of mitochondrial fractions prepared from control and TMT-treated subjects.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D009186:Myelin Sheath / Q000378:metabolism; D010766:Phosphorylation; D011768:Pyruvate Dehydrogenase Complex / Q000378:metabolism; D051381:Rats; D013347:Subcellular Fractions / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism; D014001:Tin / Q000378:metabolism*; D014018:Tissue Distribution; D014220:Trialkyltin Compounds / Q000378:metabolism*; D014267:Triethyltin Compounds / Q000378:metabolism*; D014298:Trimethyltin Compounds / Q000378:metabolism*
D011768:Pyruvate Dehydrogenase Complex; D014220:Trialkyltin Compounds; D014267:Triethyltin Compounds; D014298:Trimethyltin Compounds; C031575:triethyltin; D014001:Tin