Acute and chronic effects of LSD and 5-MeODMT on raphe-evoked dorsal root potentials in the cat.
Both acute and chronic effects of lysergic acid diethylamide (LSD) and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT) on the dorsal root potential (DRP), evoked by stimulation of the nucleus raphe magnus of the cat, were examined. Single injections of LSD potentiated while those of 5-MeODMT inhibited the raphe-evoked DRP. The electrophysiologic response produced by each drug correlates well in dosage and time-course with their reported behavioral effects. Following four consecutive daily injections of LSD, complete tolerance developed to the potentiating effect of LSD on this potential. A similar pretreatment schedule with 5-MeODMT failed to alter its acute inhibitory effect on the DRP. These results correlate well with the development of tolerance to the behavioral effects of LSD and 5-MeODMT. This system may thus provide a unique electrophysiological model to examine the effects of these drugs.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001933:Brain Stem / Q000502:physiology*; D002415:Cats; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005727:Ganglia, Spinal / Q000187:drug effects* / Q000502:physiology; D008238:Lysergic Acid Diethylamide / Q000494:pharmacology*; D008732:Methoxydimethyltryptamines / Q000494:pharmacology*; D051379:Mice; D011903:Raphe Nuclei / Q000502:physiology*; D012701:Serotonin / Q000031:analogs & derivatives* / Q000502:physiology
D008732:Methoxydimethyltryptamines; D012701:Serotonin; D008238:Lysergic Acid Diethylamide