Transplacental carcinogenesis with radioactive phosphorus: the effects of promoting agents.
In a previous experiment, using 32P as a potential transplacental carcinogen in rats, we found that the isotope caused life-span shortening, reduced growth and caused ante-dating of the time of the tumour occurrence. Liver cell changes (nuclear atypia, variation in cell size) were noted and suggested liver cell damage, possible 'initiation'. A phorbol ester (TPA) and a high fat/high protein diet were used as promoting agents on further transplacentally irradiated rats. The results were identical to the previous experiment; no evidence of promotion was found.
D000818:Animals; D002273:Carcinogens / Q000378:metabolism / Q000633:toxicity*; D004041:Dietary Fats / Q000378:metabolism / Q000633:toxicity; D005260:Female; D008431:Maternal-Fetal Exchange; D009381:Neoplasms, Radiation-Induced / Q000196:embryology*; D010761:Phosphorus Radioisotopes / Q000378:metabolism / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; D004041:Dietary Fats; D010761:Phosphorus Radioisotopes