title: [Coumarin embryopathy].
abstract: Anticoagulant therapy using coumarin derivatives (vitamin K antagonists) during early pregnancy may result in a characteristic embryopathy appearing as a phaenocopy of chondrodysplasia punctata (Conradi-Hünermann's disease). This has been suggested in advance by observations made in newborns of mothers who had been treated previously with warfarin or acenocoumon. Similar observations made in a newborn after the mother's treatment with phencoumon in early pregnancy are described in this paper. Coumarin embryopathy is proposed as a common term.
mesh_terms: D002806:Chondrodysplasia Punctata / Q000139:chemically induced* / Q000000981:diagnostic imaging; D003374:Coumarins / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011859:Radiography
chemical_list: D003374:Coumarins
vernacular_title: Coumarin-Embryopathie.