[Metabolic drug-drug interactions of chlorphenethiazine and chlorpromazine].
Owing to enzyme induction, the pretreatment of female Wistar rats with chlorphenethazine (Marophen, Elroquil) causes a shortening of the hexobarbital sleeping time and an increase in aminophenazone-N-, codeine phosphate-O- and p-nitroanisole-O-demethylation, a slight stimulation of p-nitrophenol-glucuronidation, but no change in aniline hydroxylation in the 9000-g-supernatant of liver homogenates. Comparative studies with chlorpromazine (Propaphenin) showed almost identical inductive activities which were in both cases inferior to that of phenobarbital. Consequently, the occurrence of drug-drug interactions of chlorphenethazine and chlorpromazine cannot be excluded in the framework of combined therapy.
D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D002746:Chlorpromazine / Q000031:analogs & derivatives* / Q000494:pharmacology*; D005260:Female; D006591:Hexobarbital / Q000494:pharmacology; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D006591:Hexobarbital; C002815:chlorfenethazine; D002746:Chlorpromazine
Metabolische Arzneistoff-Arzneistoff-Wechselwirkungen von Chlorphenethazin und Chlorpromazin.