[Therapy of benign diseases of the parotid gland by instillation of a resorbable protein solution into the duct system].
Non-neoplastic disorders of the parotid gland like chronic recurrent parotitis, asymptomatic gland enlargement or salivary fistulae present a therapeutic problem. Surgical removal of the gland is often difficult as scar tissue may be present in these benign diseases. Therefore alternative methods are suggested to eliminate parenchyma by inducing atrophy. This goal can also be attained by intraluminal duct occlusion. The principle consists of instillation of a resorbable protein solution into the duct system, a procedure similar to sialography injection. In animal experiments marked atrophy of parenchyma and complete reabsorption of the instilled substance within four weeks could be demonstrated histologically. The clinical experiences in 33 cases of major salivary gland diseases and three year follow up data are reported. The main advantages of the new method described are a simple technique, rapid onset of atrophy and preservation of facial nerve function.
D000818:Animals; D001284:Atrophy; D002908:Chronic Disease; D003973:Diatrizoate; D004338:Drug Combinations; D005227:Fatty Acids; D006168:Guinea Pigs; D006801:Humans; D010305:Parotid Diseases / Q000188:drug therapy*; D010306:Parotid Gland / Q000473:pathology; D010309:Parotitis / Q000628:therapy; D011409:Propylene Glycols; D011506:Proteins / Q000627:therapeutic use*; D011817:Rabbits; D012467:Salivary Gland Fistula / Q000628:therapy; D012793:Sialadenitis / Q000628:therapy; D015028:Zein
D004338:Drug Combinations; D005227:Fatty Acids; D011409:Propylene Glycols; D011506:Proteins; D003973:Diatrizoate; D015028:Zein; C020481:alcoholic prolamine solution
Die Therapie benigner Erkrankungen der Ohrspeicheldrüse durch Instillation einer resorbierbaren Eiweisslösung in das Ausführungsgangsystem.