Wash-out of noradrenaline and its metabolites by calcium-free reperfusion after ischaemia: support for the concept of ischaemia-induced noradrenaline release.
The outflow of noradrenaline (NA) and its metabolites on reperfusion after 60 min of regional ischaemia in the isolated heart of the rat was not diminished when calcium was omitted from the reperfusion medium. The findings suggest a release of NA during ischaemia, washed-out at reperfusion.
D000818:Animals; D002118:Calcium / Q000502:physiology*; D003326:Coronary Circulation; D005947:Glucose / Q000378:metabolism; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains
D007773:Lactates; D019344:Lactic Acid; D005947:Glucose; D002118:Calcium; D009638:Norepinephrine