Decreased adenylate cyclase responsiveness of transformed cells correlates with the presence of a viral transforming protein.
The adenylate cyclase responsiveness of transformed fibroblastic and epithelial cell lines to forskolin, fluoride, guanine nucleotides and cholera toxin was reduced compared to their parental counterparts. This phenomenon was observed in lines transformed by either RNA or DNA tumor viruses, and in the case of polyoma virus, coincided with the expression of middle T antigen. The data suggest that decreased responsiveness of adenylate cyclase to non-hormone activators is a general consequence of viral transformation and may be related to viral regulation of protein kinase activity.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D006224:Cricetinae; D004285:Dogs; D011494:Protein Kinases / Q000378:metabolism; D051381:Rats; D014764:Viral Proteins / Q000502:physiology
D014764:Viral Proteins; D011494:Protein Kinases; D000262:Adenylyl Cyclases