title: A unified approach to age-dependent metabolic modeling.
abstract: A generalized approach for estimating the effect of age on deposition fractions and retention half-times is presented. The theory employs measured physiological and anatomical parameters and relates these to metabolic parameters within a general framework intended for use in setting secondary limits for exposure of the general public. Calculated results indicate that younger ages will be characterized by increased deposition fractions and decreased half-times for retention following radionuclide uptakes. Representative examples are provided for radionuclides of current interest in health physics practice.
mesh_terms: D000293:Adolescent; D000328:Adult; D000375:Aging; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D006207:Half-Life; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008433:Mathematics; D008954:Models, Biological; D009929:Organ Size; D011868:Radioisotopes / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D011868:Radioisotopes