Induction of cytosolic and microsomal epoxide hydrolases by the hypolipidaemic compound nafenopin in the mouse liver.
The repeated oral administration of nafenopin, a hypolipidaemic compound, at a dose of 100 mg/kg to male C57BL/6, DBA/2, Balb c and C3H mice caused an increase in the specific activity of liver cytosolic epoxide hydrolase, the activity of microsomal epoxide hydrolase was also increased in all except the C3H mice. The dose dependence and the specificity of this induction was investigated in male DBA/2 mice. In the range of 10-200 mg/kg nafenopin the induction of the two hydrolase activities was found to increase with increasing doses of the test compound. Two other cytosolic enzyme activities, lactate dehydrogenase and glutathione S-transferase, remained essentially unchanged within the dose range investigated.
D000818:Animals; D003600:Cytosol / Q000201:enzymology; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction; D004851:Epoxide Hydrolases / Q000096:biosynthesis*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008861:Microsomes / Q000201:enzymology; D009255:Nafenopin / Q000494:pharmacology*; D011422:Propionates / Q000494:pharmacology*
D011422:Propionates; D009255:Nafenopin; D004851:Epoxide Hydrolases