The effect of aspirin, indomethacin and sodium meclofenamate on coronary artery ligation arrhythmias in anaesthetized rats.
The intravenous administration of either aspirin, (in doses of 1 and 3 mg/kg) sodium meclofenamate (1 and 3 mg/kg) or indomethacin (1 and 3 mg/kg) markedly reduced ventricular arrhythmias (VT and VF) induced by coronary artery ligation in anaesthetised rats. Their effect were very pronounced on ventricular ectopic activity occurring between the sixteenth and thirtieth min. These effects suggest the desirability of combining the non steroidal anti-inflammatory drugs with beta-adrenergic blockers in the treatment of ventricular arrhythmias following acute myocardial infarction.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000503:physiopathology; D001241:Aspirin / Q000627:therapeutic use; D003331:Coronary Vessels / Q000601:surgery; D004195:Disease Models, Animal; D006439:Hemodynamics / Q000187:drug effects; D007213:Indomethacin / Q000627:therapeutic use; D008026:Ligation; D008297:Male; D008469:Meclofenamic Acid / Q000627:therapeutic use; D051381:Rats; D011919:Rats, Inbred Strains
D000893:Anti-Inflammatory Agents; D008469:Meclofenamic Acid; D001241:Aspirin; D007213:Indomethacin