title: A controlled endoscopic study comparing the toxic effects of sulindac, naproxen, aspirin, and placebo on the gastric mucosa of health volunteers.
abstract: Sixty volunteers were endoscopically evaluated to compare gastric mucosal injury following oral administration of sulindac, naproxen, aspirin, or placebo for two consecutive seven-day periods. A single-blind technique was utilized wherein the endoscopist was unaware which drug each volunteer had received. The following dosages were employed for the two study periods: sulindac, 150 and 200 mg, b.i.d., naproxen, 250 and 375 mg, b.i.d., and aspirin, 650 and 975 mg, q.i.d. The only subject who developed a frank ulcer with mucosal bleeding was in the sulindac group, however volunteers taking sulindac demonstrated statistically less significant mucosal injury on endoscopic examination than those receiving naproxen or aspirin.
mesh_terms: D000328:Adult; D001241:Aspirin / Q000009:adverse effects* / Q000097:blood; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects*; D005773:Gastroscopy; D006801:Humans; D007192:Indenes / Q000009:adverse effects*; D008297:Male; D009288:Naproxen / Q000009:adverse effects* / Q000097:blood; D010919:Placebos; D013276:Stomach Ulcer / Q000139:chemically induced; D013467:Sulindac / Q000009:adverse effects* / Q000097:blood
chemical_list: D007192:Indenes; D010919:Placebos; D013467:Sulindac; D009288:Naproxen; D001241:Aspirin