Hypoglycaemia due to azapropazone-tolbutamide interaction.
We report a case of hypoglycaemia due to a 'first-dose' interaction between azapropazone and tolbutamide. The mechanism was probably by displacement of tolbutamide from protein binding sites, and it is recommended that azapropazone should be avoided in patients receiving tolbutamide.
D001032:Apazone / Q000009:adverse effects* / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000188:drug therapy; D004347:Drug Interactions; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D011843:Radiculopathy / Q000188:drug therapy; D014044:Tolbutamide / Q000009:adverse effects* / Q000627:therapeutic use; D014227:Triazines / Q000009:adverse effects*
D014227:Triazines; D014044:Tolbutamide; D001032:Apazone