Neuroendocrine and behavioral effects of m-chlorophenylpiperazine administration in rhesus monkeys.
The effects of m-chlorophenylpiperazine (mCPP), a serotonin receptor agonist, on the release of plasma prolactin (PRL), growth hormone (GH), and cortisol in the rhesus monkey were studied. mCPP was administered intravenously at doses of 0.5, 1.5, and 3.0 mg/kg. GH and cortisol were increased significantly at all doses while PRL was significantly increased only following administration of 3.0 mg/kg mCPP. mCPP administration also produced behavioral alterations in each monkey, including sedation, penile erection, and defecation. PRL, GH and behavioral responses to mCPP were completely blocked by pretreatment with the serotonin antagonist metergoline (MTG). However, pretreatment treatment with MTG failed to entirely anagonize the cortisol response to mCPP. These data suggest that mCPP has prominent neuroendocrine and behavioral effects which are mediated, in part, by serotonergic mechanisms.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003672:Defecation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D013006:Growth Hormone / Q000097:blood; D006854:Hydrocortisone / Q000097:blood; D006993:Hypnotics and Sedatives; D008253:Macaca mulatta; D008297:Male; D009490:Neurosecretory Systems / Q000187:drug effects*; D010413:Penis / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood; D011985:Receptors, Serotonin / Q000187:drug effects
D006993:Hypnotics and Sedatives; D010879:Piperazines; D011985:Receptors, Serotonin; D011388:Prolactin; D013006:Growth Hormone; C015068:1-(3-chlorophenyl)piperazine; D006854:Hydrocortisone