[Biological activity of 4-hydroxy-5-formylbenzoic acid derivatives. II. Esters and Schiff bases with antimicrobial activity].
A number of hitherto undescribed 4-hydroxy-5-formylbenzoic acid derivatives (A), have been prepared and characterized. (formula; see text) Esters (X = CH3) and Schiff's bases (Z = N-aryl) were prepared by conventional methods and were obtained in satisfactory yield and in a good state of purity. The prepared compounds have been tested for "in vitro" activity against Gram+ bacteria (S.epidermidis, B.subtilis, B.anthracis, M.paratuberculosis), Gram- bacteria (P.aeruginosa, S.typhi murium, E.coli Bb, S.typhi O, S.typhi infantis, S.paratyphi A, S.paratyphi B) and fungi (C.albicans, A.niger, S.cerevisiae) by agar-diffusion method (Kirby-Bauer modified). The prepared compounds, generally, showed inhibitory activity against Gram+ bacteria. Esters (A: X = CH3) showed antibacteric and antimycotic activity. The greatest activity was observed in the methyl ester (XV) of 4-hydroxy-5-formylbenzoic acid (I).
D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D062385:Hydroxybenzoates / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D012545:Schiff Bases / Q000494:pharmacology
C040700:4-hydroxy-5-formylbenzoic acid; D062385:Hydroxybenzoates; D012545:Schiff Bases
Attivita' biologica di derivati dell'acido 4-idrossi-5-formil benzoico. II. Esteri e basi di Schiff ad attività antimicrobica.