Biologically active halophthaloylpeptides. I. Synthesis of tetrachlorophthaloylamino acids and dipeptide derivatives.
The synthesis of a series of tetrachlorophthaloylamino acids and some of the corresponding methyl esters is described. Coupling of tetrachlorophthaloylamino acids with amino acid methyl esters by the N,N'-dicyclohexylcarbodiimide method yielded the desired tetrachlorophthaloyldipeptide methyl esters. All of the synthesized tetrachlorophthaloylamino acids, esters and some dipeptide methyl esters were found to be active against a number of microorganisms.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004151:Dipeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010795:Phthalic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000900:Anti-Bacterial Agents; D004151:Dipeptides; D010795:Phthalic Acids