Improvement in injury induced hypocalcia by high-dose naloxone intervention.
Naloxone hydrochloride was used to re-establish normal calcium activities in the extracellular space of the injured spinal cord. The micromolar levels of calcium which occur immediately after injury were improved above control values by 1 h 30 min post-injury; normal activities occurred at 2 h 45 min. Such a restitution of ionic levels after injury may contribute to the beneficial effects of naloxone in traumatic injury.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D004285:Dogs; D005110:Extracellular Space / Q000378:metabolism*; D009270:Naloxone / Q000008:administration & dosage / Q000627:therapeutic use*; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000378:metabolism
D009270:Naloxone; D002118:Calcium