title: Observations on plasma and red cell lipids in hereditary spherocytosis.
abstract: Plasma lipids and red cell lipids were determined in hereditary spherocytosis (HS), 15 unsplenectomized and eight splenectomized patients. Plasma lipids (cholesterol: total, free and high density lipoproteins, free fatty acids, and phospholipids) were markedly decreased in HS, especially in the unsplenectomized patients. Concomitantly, red cell membrane lipids (free cholesterol and phospholipids: total, phosphatidyl ethanolamine, sphingomyelin, phosphatidyl choline, and lysophosphatidyl choline) were also diminished. The plasma lipids stay low even after splenectomy although partially restored. Thus, decreased membrane surface, a hallmark of HS, could be partly attributed to the diminished membrane lipids induced by plasma lipid abnormalities in the patients.
mesh_terms: D002784:Cholesterol / Q000097:blood; D004912:Erythrocytes / Q000032:analysis; D005227:Fatty Acids / Q000097:blood; D006801:Humans; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D013103:Spherocytosis, Hereditary / Q000097:blood*; D013156:Splenectomy
chemical_list: D005227:Fatty Acids; D008055:Lipids; D008075:Lipoproteins, HDL; D002784:Cholesterol