Determination of 3,7-dimethyl-1-(5-oxohexyl)-xanthine (pentoxifylline) and its 3,7-dimethyl-1-(5-hydroxyhexyl)-xanthine metabolite in the plasma of patients with multiple diseases using high-performance liquid chromatography.
Pharmacokinetic studies of pentoxifylline in elderly patients with multiple diseases are described. Because of the low plasma levels of pentoxifylline and its hydroxy metabolite a new high-performance liquid chromatographic method was established. Under our chromatographic conditions, piracetam, a nootropic drug, can be easily separated from simultaneously applied pentoxifylline and its metabolite. Piracetam shows no appreciable ultraviolet absorption above 230 nm and cannot be detected at 268 nm.
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D007700:Kinetics; D010431:Pentoxifylline / Q000031:analogs & derivatives* / Q000097:blood*; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013805:Theobromine / Q000031:analogs & derivatives*
C025189:lisofylline; D013805:Theobromine; D010431:Pentoxifylline