[Pharmacokinetics of the new Soviet anti-arrhythmia preparation etacizin].
Ten patients without marked abnormalities on the part of the liver and kidneys were examined for the pharmacokinetics of a new Soviet antiarrhythmic drug etacizin. The drug was injected intravenously at a rate of 0.5-0.8 mg/kg bw. The blood required for determining drug concentrations was taken 1, 2, 3 and 4 hours after drug jet injection. It was demonstrated that the drug half-life was on the average 164 +/- 24.7 min, exceeding 2 times the half-life of etmozine, a drug of the same series applied to the treatment of some forms of heart rhythm abnormalities.
D000889:Anti-Arrhythmia Agents / Q000097:blood*; D001145:Arrhythmias, Cardiac / Q000097:blood / Q000188:drug therapy; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D016293:Moricizine / Q000031:analogs & derivatives*; D010640:Phenothiazines / Q000097:blood*; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; C027240:diethylamino-ethmozine; D016293:Moricizine
Farmakokinetika novogo otechestvennogo antiarutmicheskogo preparata étatsizina.