Dominant lethal test in female mice treated with methyl mercury chloride.
Female BALB/c mice were treated with a single intraperitoneal injection of 0, 2.5, 5.0 or 7.5 mg methyl mercury chloride per kg body weight and subjected to the dominant lethal assay at 6 different time intervals between exposure and mating. Cyclophosphamide (210 mg/kg body weight) was used as a positive control. The main observation appeared to be a statistically highly significant increase in especially pre- and early post-implantation foetal losses. This was most evident when all data (the 6 consecutive weeks of mating) were pooled.
D000818:Animals; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D008767:Methylmercury Compounds / Q000633:toxicity*; D051379:Mice; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects*; D010053:Ovary / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects
D008767:Methylmercury Compounds; C004925:methylmercuric chloride