Ribosome-lamellae complexes in benign plasma cells accompanying neoplastic infiltrates.
Two examples of ribosome-lamellae complexes (RLCs) occurring in benign plasma cells are presented. These were seen utilizing transmission electron microscopy in a case of mycosis fungoides in skin and a fibrosarcoma of a lower extremity. In both cases the accompanying plasmacytic infiltrate was interpreted as reactive and not malignant. Once thought to be a specific marker for hairy cell leukemia, RLCs now have been described in a wide variety of neoplastic diseases (mostly hematologic) and in a few examples of nonneoplastic conditions. RLCs have not been described previously in benign plasma cells. A review of the literature with respect to occurrence and significance of RLCs is presented.
D000328:Adult; D000368:Aged; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology*; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009182:Mycosis Fungoides / Q000473:pathology*; D009940:Organoids; D010950:Plasma Cells / Q000648:ultrastructure*; D012270:Ribosomes