Effect of thyroxine-induced hyperthyroidism on some testicular enzymes of the pyruvate/malate cycle.
The effect of thyroxine on the specific activities of testicular enzymes of the pyruvate/malate cycle involved in lipogenesis were studied in prepubertal, pubertal and adult rats. Thyroxine (25 micrograms/100 g body weight) treatment for 1 month increased the specific activity of isocitrate dehydrogenase (NADP+) but the specific activities of ATP-citrate lyase, malate dehydrogenase and malic enzyme were inhibited. Withdrawal of thyroxine treatment from hyperthyroid rats brought back all enzyme activities to normal. The study reveals a direct, specific influence of thyroxine on different testicular enzymes of the pyruvate/malate cycle.
D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism*; D000818:Animals; D006980:Hyperthyroidism / Q000139:chemically induced / Q000201:enzymology*; D007521:Isocitrate Dehydrogenase / Q000378:metabolism*; D008291:Malate Dehydrogenase / Q000378:metabolism*; D008293:Malates / Q000378:metabolism; D008297:Male; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D012741:Sexual Maturation; D013737:Testis / Q000201:enzymology* / Q000254:growth & development; D013974:Thyroxine / Q000633:toxicity*
D008293:Malates; D011773:Pyruvates; D019289:Pyruvic Acid; D008291:Malate Dehydrogenase; D007521:Isocitrate Dehydrogenase; C034544:D-malate dehydrogenase (decarboxylating); D001275:ATP Citrate (pro-S)-Lyase; D013974:Thyroxine