[Complement activation during extracorporeal circulation. A model for understanding lesional pulmonary edema].
The complement system (CH50, C3, C4, C3 PA) was monitored during extra-corporeal circulation in 10 patients with ischemic-heart disease. Mean concentrations of CH50, C3, C4, and C3 PA significantly decreased as early as 5 minutes after initiation of the extra-corporeal circulation and decrement remain steady all over the surgical procedure. Transient neutropenia occurred early during the procedure. A significant hypoxemia was present only 24 hours after surgery. We suggest that a complement mediated leukostasis might occur with sequestration in the lungs and contribute to endothelial cell damage with pulmonary edema known as the "post-pump syndrome".
D000328:Adult; D000368:Aged; D003167:Complement Activation; D003170:Complement Pathway, Alternative; D003165:Complement System Proteins / Q000032:analysis; D005112:Extracorporeal Circulation / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000209:etiology; D011654:Pulmonary Edema / Q000209:etiology* / Q000276:immunology
D003165:Complement System Proteins
Activation du complément au cours de la circulation extra-corporelle. Un modèle pour comprendre l'oedème pulmonaire lésionnel.