[Pharmacokinetics of human fibroblast interferon in rats].
Pharmacokinetic behaviors of human fibroblast interferon (HuIFN-beta) administered intravenously to rats were examined. After intravenous injection, plasma interferon level decreased in a biexponential fashion having the half-times of 15 min and 120 min respectively. Distribution levels of HuIFN-beta in the tissues at 30 min, though the actual concentrations were less than that of plasma, were observed according to the following order; kidney greater than adrenal greater than lung greater than spleen greater than liver greater than testis. Small amounts of HuIFN-beta were also detected in the thoracic lymph and bile but no HuIFN-beta was found in urine. The in vitro study indicated that the stability of HuIFN-beta was different in each tissue homogenates and body fluids. From the results obtained, we concluded that HuIFN-beta exhibited a low distributional character to the tissues when administered intravenously. It was also suggested that the kidney and the liver were the main catabolic sites of HuIFN-beta.
D000818:Animals; D006207:Half-Life; D006801:Humans; D007370:Interferon Type I / Q000378:metabolism*; D007700:Kinetics; D008196:Lymph / Q000378:metabolism; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D014018:Tissue Distribution
D007370:Interferon Type I