A pharmacokinetic study of repeated doses of a new controlled release form of ketoprofen.
Nine volunteers were dosed once daily for 15 days with a controlled release formulation of ketoprofen. The peak plasma ketoprofen concentration (4.2 micrograms/ml) and apparent elimination half-life (8.4 h) did not markedly alter during the course of the study. Plasma ketoprofen concentrations at 24 h after dosing were 0.79 micrograms/ml. These minimum ketoprofen concentrations suggest that this formulation is suitable as a once daily dosing regimen.
D000328:Adult; D003692:Delayed-Action Preparations; D006801:Humans; D007660:Ketoprofen / Q000008:administration & dosage / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D010666:Phenylpropionates / Q000378:metabolism*
D003692:Delayed-Action Preparations; D010666:Phenylpropionates; D007660:Ketoprofen