Mesenteric desmoid tumor in Gardner's syndrome treated by sulindac.
Mesenteric desmoid tumors are a recognized sequela of colectomy for polyposis coli of Gardner's type. Relentless growth and recurrence carry a poor prognosis. Recently, nonsteroidal anti-inflammatory drugs have been used to halt the growth of these tumors, presumably by interfering with prostaglandin metabolism. A 36-year-old man presented with small-bowel obstruction secondary to a large, diffuse mesenteric desmoid six years following colectomy and ileoproctostomy. Laparotomy revealed it to be unresectable. Postoperatively, he was started on sulindac (Clinoril) 100 mg twice a day. His obstruction resolved, and he remains well at 11 months. A CT scan shows diminution in the size of the tumor. Nonsteroidal anti-inflammatory agents may be an alternative to chemotherapy and radiotherapy in treating mesenteric desmoids.
D000328:Adult; D003082:Colectomy / Q000009:adverse effects; D005350:Fibroma / Q000188:drug therapy* / Q000209:etiology; D005736:Gardner Syndrome / Q000150:complications* / Q000601:surgery; D006801:Humans; D007192:Indenes / Q000627:therapeutic use*; D008297:Male; D008643:Mesentery; D010534:Peritoneal Neoplasms / Q000188:drug therapy* / Q000209:etiology; D011448:Prostaglandin Antagonists; D013467:Sulindac / Q000627:therapeutic use*
D007192:Indenes; D011448:Prostaglandin Antagonists; D013467:Sulindac