Iatrogenic morbidity accompanying suppression of temporal arteritis by adrenal corticosteroids.
The records of 19 patients receiving corticosteroid therapy for temporal arteritis were reviewed. Of 11 patients (58%) who suffered major corticosteroid related complications (group A), four died. Eight patients (group B) remained free of serious corticosteroid related complications. The average daily maintenance prednisone dose was 26.3 mg in group A and 13 mg in group B. Although all disease recrudescenses in both groups were treated by increasing the corticosteroid dose, a slower tapering of the dose to the pre-flare level was observed in group A. These findings emphasize the necessity of keeping the maintenance corticosteroid dose in patients with temporal arteritis at the lowest level consistent with suppression of disease activity.
D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000368:Aged; D004334:Drug Administration Schedule; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology; D013700:Giant Cell Arteritis / Q000188:drug therapy*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D008297:Male; D001523:Mental Disorders / Q000139:chemically induced*; D008875:Middle Aged; D009135:Muscular Diseases / Q000139:chemically induced*; D010024:Osteoporosis / Q000139:chemically induced*; D010437:Peptic Ulcer / Q000139:chemically induced; D011241:Prednisone / Q000009:adverse effects*
D000305:Adrenal Cortex Hormones; D011241:Prednisone