[Changes in the activity of flavoprotein-dependent monooxygenase of immunocompetent cells in the mouse in response to antigens and low-molecular immunomodulators].
The activity of flavoproteid-dependent monooxigenase (benzpyrene-3-monooxigenase) in thymocytes, splenocytes and macrophages was studied in dynamics of development of the immune response to ram erythrocytes and with administration of low-molecular immunodepressants and immune stimulators to mice. It is shown that primary and secondary immunizations decrease the enzyme activity in splenocytes and macrophages. In the thymus cells it grows thrice as high a day after the antigen administration and then lowers. It is supposed that stimulation at the initial stages of the monooxigenase activity in the thymus and its inhibition in splenocytes and macrophages are main stages in development of the immune response. The data obtained are discussed accounting for cytochrome P-450 participation in metabolism of endogenic steroids and prostaglandins which are immunogenesis regulators.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000378:metabolism*; D001579:Benzopyrene Hydroxylase / Q000378:metabolism*; D004912:Erythrocytes / Q000276:immunology*; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008214:Lymphocytes / Q000201:enzymology*; D008264:Macrophages / Q000201:enzymology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000201:enzymology*; D013950:Thymus Gland / Q000201:enzymology*
D000276:Adjuvants, Immunologic; D007166:Immunosuppressive Agents; D001579:Benzopyrene Hydroxylase; D001189:Aryl Hydrocarbon Hydroxylases
Izmenenie aktivnosti flavoproteid-zavisimoĭ monooksigenazy immunokompetentnykh kletok mysheĭ pod vliianiem antigena i nizkomolekuliarnykh immunomoduliatorov.