[Combined action of gamma irradiation and 5-bromodeoxyuridine on human chromosomes].
A combined effect has been studied of 5-bromo-deoxyuridine (BDU) and gamma-radiation on human lymphocytes at the G0 stage. BDU is shown to induce chromatid aberrations irrespective of its radiation. The frequency of chromatid aberrations rises with the BDU concentration. BDU modifies the effect of gamma-radiation on human lymphocytes at the G0 stage, increasing the number of chromosome aberrations. BDU slows down the lymphocyte cell cycle.
D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006801:Humans; D007399:Interphase / Q000187:drug effects / Q000528:radiation effects; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure
D001973:Bromodeoxyuridine
Kombinirovannoe deĭstvie gamma-oblucheniia i 5-bromdezoksiuridina na khromosomy cheloveka.