Mechanism of freeze-thaw instability of aluminum hydroxycarbonate and magnesium hydroxide gels.
The effect of freeze-thaw cycles on the physical stability of aluminum hydroxycarbonate and magnesium hydroxide gels was studied. Coagulation following a freeze-thaw cycle, leading to the formation of visible aggregates, affected the content uniformity of both gels. The freeze-thaw cycles did not affect the crystal form or surface characteristics of the gels as determined by X-ray powder diffraction and point of zero charge, but caused a slight reduction in the rate of acid neutralization and a large increase in the rate of sedimentation. The greatest effect was observed after the first freeze-thaw cycle. While the duration of freezing was not a factor, the rate of freezing was important and was inversely related to the aggregate size. The aggregates which formed following a freeze-thaw cycle were not redispersed by shaking, but were reversed by ultrasonic treatment or homogenization. The adsorption of polymers or surface-active agents prior to freezing reduced and, in some cases, prevented the formation of aggregates. The physical instability produced by a freeze-thaw cycle was explained by the modified DLVO theory. The force exerted on the particles by the growing ice crystals forced the particles into the primary minimum, producing strong interparticle attraction. On thawing, simple agitation did not provide enough force to overcome the attractive force of the primary minimum. Adsorption of polymers or surface-active agents increased the steric repulsive force and prevented the particles from reaching the primary minimum.
D000536:Aluminum Hydroxide; D002626:Chemistry, Pharmaceutical; D004355:Drug Stability; D005615:Freezing; D006863:Hydrogen-Ion Concentration; D065347:Hypromellose Derivatives; D008274:Magnesium; D008276:Magnesium Hydroxide; D008747:Methylcellulose / Q000031:analogs & derivatives / Q000032:analysis; D013500:Surface Tension; D013501:Surface-Active Agents; D014961:X-Ray Diffraction
D013501:Surface-Active Agents; C025173:basic aluminum carbonate gel; D065347:Hypromellose Derivatives; D000536:Aluminum Hydroxide; D008747:Methylcellulose; D008274:Magnesium; D008276:Magnesium Hydroxide