Location of RNase and RNase inhibitor on free cytoplasmic mRNA-protein particles from human placenta.
Free cytoplasmic mRNPs were isolated from human placenta. An activity of RNase was associated with these particles but was mostly inhibited by a labile protein inhibitor. Both RNase and RNase inhibitor were extractable from mRNPs by 0.5 M KCl. The nature of the association of the RNase-RNase inhibitor complex with mRNPs makes it suitable as a putative system for control of expression and turnover of mRNPs and therefore of protein synthesis.
D003593:Cytoplasm / Q000201:enzymology; D005260:Female; D006801:Humans; D010920:Placenta / Q000201:enzymology*; D011247:Pregnancy; D012333:RNA, Messenger / Q000378:metabolism; D012260:Ribonucleases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D012261:Ribonucleoproteins / Q000378:metabolism*
D012333:RNA, Messenger; D012261:Ribonucleoproteins; D012260:Ribonucleases