The in vivo effects of manganese and zinc on delta-aminolevulinic acid dehydratase activity inhibited by lead.
The in vivo effects of zinc (Zn) and manganese (Mn) on the activity of delta-aminolevulinic acid dehydratase (5-aminolevulinate hydrolyase, ALAD, EC 4.2.1.24) in blood with and without inhibition by lead and on the functions of the liver and kidney were studied in rabbits. Administration of Zn or Mn alone caused little change in any of the 29 parameters tested at concentrations of 5, 10, 25 or 50 mumol element/kg body weight. Administration of 5 mumol lead/kg inhibited ALAD activity in blood, but it did not induce any marked effects on the indices of hepatic and renal functions. In simultaneous i.v. injection with lead and manganese, both at a dose of 5 mumol/kg, however, the recovery process of ALAD activity was delayed. Three out of 29 parameters tested, beta-lipoprotein, triglyceride and aldolase, increased significantly one day after simultaneous injection with lead and manganese. Equimolar zinc did not show either an antagonistic or cooperative effect on these three parameters and the ALAD activity in blood.
D000818:Animals; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood; D007275:Injections, Intravenous; D007668:Kidney / Q000187:drug effects; D007854:Lead / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000097:blood; D008099:Liver / Q000187:drug effects; D008297:Male; D008345:Manganese / Q000494:pharmacology; D000623:Porphobilinogen Synthase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D011817:Rabbits; D014280:Triglycerides / Q000097:blood; D015032:Zinc / Q000494:pharmacology
D008077:Lipoproteins, LDL; D014280:Triglycerides; D007854:Lead; D008345:Manganese; D005634:Fructose-Bisphosphate Aldolase; D000623:Porphobilinogen Synthase; D015032:Zinc