title: A cardiovascular model for studying impairment of cerebral function during +Gz stress.
abstract: A digital computer model of the human cardiovascular system has been developed which can be used for studying impairment of cerebral function during +Gz stress. The model includes simulation of the arterial and venous systems, the heart, baroreceptor control of heart rate, control of venous tone, and the effect of gravity. Model predictions suggest that, for unprotected subjects, carotid pressure at eye level decreases to 50 mm Hg (beginning of peripheral light loss) at approximately 2.7 Gz. The pressure decreases to 20 mm Hg (beginning of central light loss) at approximately 3.6 Gz. An anti-G suit provides an extra 1.1 to 1.5 Gz protection. Even though blood pressure supplying retinal vessels drops significantly at the above G levels, cerebral blood flow is maintained due to protective and compensatory mechanisms. These observations compare favorably with results reported in the literature. The results suggest that this model can be used to improve our understanding of the cardiovascular system's response to +Gz stress.
mesh_terms: D000337:Aerospace Medicine; D001794:Blood Pressure; D001921:Brain / Q000098:blood supply / Q000503:physiopathology*; D002339:Carotid Arteries / Q000502:physiology; D003201:Computers; D006112:Gravitation; D005676:Gravity Suits; D006801:Humans; D008955:Models, Cardiovascular