Evaluation of monoaminergic receptors in the genetically epilepsy prone rat.
The intensity of sound-induced convulsions in the genetically epilepsy-prone rat (GEPR) was reduced in a dose related fashion by intracerebroventricular administration of dobutamine, (beta 1 agonist), terbutaline (beta 2 agonist) or phenylephrine (alpha 1 agonist). BHT-920 (alpha 2 agonist) did not cause a dose-related decrease in sound-induced convulsion intensity. Binding studies showed that whole brain alpha and beta receptor densities (Bmax) were normal while the Kd was increased for the beta ligand in GEPR brain.
D000161:Acoustic Stimulation; D000818:Animals; D004280:Dobutamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004827:Epilepsy / Q000503:physiopathology*; D005260:Female; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains; D010656:Phenylephrine / Q000494:pharmacology; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*; D012640:Seizures / Q000503:physiopathology; D013726:Terbutaline / Q000494:pharmacology
D011941:Receptors, Adrenergic; D010656:Phenylephrine; D004280:Dobutamine; D013726:Terbutaline