Red-cell sensitization in myelofibrosis.
Using an enzyme-linked immunosorbent assay (ELISA), elevated RBC-Ig of the IgG and IgM class were found in 8 of 14 patients with idiopathic myelofibrosis. In 2 patients with high levels of RBC-Ig the direct Coombs' test was positive. It is supposed that immune haemolysis may contribute to the anaemia in some patients with idiopathic myelofibrosis.
D000368:Aged; D003298:Coombs Test; D004912:Erythrocytes / Q000032:analysis / Q000503:physiopathology*; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006461:Hemolysis; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007770:L-Lactate Dehydrogenase / Q000032:analysis; D008297:Male; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000097:blood* / Q000503:physiopathology; D011877:Radionuclide Imaging; D013154:Spleen / Q000000981:diagnostic imaging; D013667:Technetium
D006454:Hemoglobins; D007136:Immunoglobulins; D013667:Technetium; D007770:L-Lactate Dehydrogenase