Effects of alpha-tocopherol administration on red blood cell membrane lipid peroxidation in hemodialysis patients.
The result of vitamin E treatment in 19 uremic patients in chronic hemodialysis is evaluated. In particular, the levels of erythrocyte malonyldialdehyde (MDA) and vitamin E were determined, and the fatty acid composition of red blood cell (RBC) membrane before and after treatment with parenterally administered vitamin E. A decrease of RBC MDA levels, an increase of RBC vitamin E concentrations, and a decreased saturated fatty acid to unsaturated fatty acid ratio were found after treatment with vitamin E. There was a statistically significant increase of the packed RBC volume.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D005260:Female; D006801:Humans; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008297:Male; D008315:Malondialdehyde / Q000096:biosynthesis; D008563:Membrane Lipids / Q000378:metabolism; D008875:Middle Aged; D006435:Renal Dialysis; D024505:Tocopherols; D014511:Uremia / Q000097:blood* / Q000188:drug therapy; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D008054:Lipid Peroxides; D008563:Membrane Lipids; D014810:Vitamin E; D008315:Malondialdehyde; D024502:alpha-Tocopherol; D024505:Tocopherols