Serum amyloid A protein and C-reactive protein levels in pulmonary tuberculosis: relationship to amyloidosis.
C-reactive protein and serum amyloid A protein levels were measured in 54 patients with pulmonary tuberculosis. The primary tuberculous complex was associated with an insignificant acute phase response, while post-primary tuberculosis without evidence of lung destruction caused modest increases in C-reactive protein and serum amyloid A protein. In most patients with post-primary pulmonary tuberculosis with significant pulmonary destruction there was a major acute phase response, with very high serum amyloid A protein and C-reactive protein levels. The response in these patients is most likely to be due to secondary bacterial infection in addition to infection by Mycobacterium tuberculosis. Patients with miliary tuberculosis showed a major acute phase response. Serum amyloid A protein and C-reactive protein levels decreased rapidly after initiation of treatment in the patients with post-primary tuberculosis without significant pulmonary destruction.
D000293:Adolescent; D000328:Adult; D000682:Amyloid / Q000032:analysis*; D000686:Amyloidosis / Q000209:etiology; D000995:Antitubercular Agents / Q000627:therapeutic use; D002097:C-Reactive Protein / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008875:Middle Aged; D000685:Serum Amyloid A Protein / Q000032:analysis*; D014391:Tuberculosis, Miliary / Q000097:blood; D014397:Tuberculosis, Pulmonary / Q000097:blood* / Q000150:complications / Q000188:drug therapy
D000682:Amyloid; D000995:Antitubercular Agents; D000685:Serum Amyloid A Protein; D002097:C-Reactive Protein