Toxic effects of selenodiglutathione on pregnant mice.
A single dose of selenodiglutathione (GSSeSG) or sodium selenite (SS) was injected i.v. into pregnant CD-1 mice on day 12 of gestation at dosages varying from 16.4-32.0 mumol/kg body weight. Dose-dependent elevation of maternal death rates was observed for both treatments, and the slope of the dose-response curve was significantly steeper following GSSeSG treatment. However, fetotoxic effects were not different between the treatments.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005978:Glutathione / Q000031:analogs & derivatives* / Q000633:toxicity; D051379:Mice; D008813:Mice, Inbred ICR; D016566:Organoselenium Compounds; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D020887:Selenious Acid; D012643:Selenium / Q000633:toxicity*
D016566:Organoselenium Compounds; C017710:selenodiglutathione; D020887:Selenious Acid; D005978:Glutathione; D012643:Selenium