title: The effects of sym. Triazinones on developmental stages of Eimeria tenella, E. maxima and E. acervulina: a light and electron microscopical study.
abstract: The development of three chicken coccidia (Eimeria tenella, E. acervulina and E. maxima) was studied by means of light and electron microscopy. One group of chickens infected with 6000-20,000 oocysts received a single dose of 5 mg/kg body weight (comparable to approx. 25 ppm in the feed) Bay Vg 7183 or Bay Vi 9142 orally (on day 3 or 4 p.i.), whereas others received two doses (on days 3 and 4 or on days 4 and 5 p.i.). The animals were killed on days 3, 4, 5, 6 and 7 p.i. and parts of the mucosa were dissected from the caecum (E. tenella), the ileum (E. maxima) and the duodenum (E. acervulina). Significant damage was observed in comparison to the controls, affecting nearly all of the parasites in those animals that had been treated twice, whereas some of the parasites remained microscopically unchanged after only one treatment. In general, the perinuclear space, mitochondria and the endoplasmic reticulum were found to be considerably enlarged. Nuclear divisions were disturbed in schizonts and microgamonts, thus resulting in a greatly reduced production of parasites. The most important damage occurring in the macrogamonts concerned the wall-forming bodies II. As they burst, the formation of intact oocyst-walls was hindered, even if fertilization had taken place.
mesh_terms: D000818:Animals; D002645:Chickens / Q000469:parasitology*; D003048:Coccidiosis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D003049:Coccidiostats / Q000494:pharmacology* / Q000627:therapeutic use; D004539:Eimeria / Q000187:drug effects* / Q000254:growth & development; D008854:Microscopy, Electron; D011201:Poultry Diseases / Q000188:drug therapy* / Q000469:parasitology; D013045:Species Specificity; D014227:Triazines / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D003049:Coccidiostats; D014227:Triazines; C032645:BAY-g 7138; C036670:toltrazuril