The antagonistic effects of naloxone on hypermotility in mice induced by dynorphin-(1-13) using a multi-dimensional behavioral analysis.
The effects of intracerebral injection of dynorphin-(1-13) on spontaneous locomotor activity were investigated by using a newly devised multi-dimensional behavioural analyser based on a capacitance system. With this equipment, nine different measures of behavior exhibited by the mouse can be recorded. It was found that dynorphin-(1-13) (0.3 and 1 microgram) produced a significant increase in the linear locomotion recorded on the 1/1 and 1/2 counters. In addition, dynorphin-(1-13) (0.3 micrograms) significantly increased the grooming behavior recorded on the 1/16 counter. As the dynorphin-(1-13)-induced behavioural effects were reversed by pretreatment with relatively small doses of naloxone (0.5, 1 and 2 mg/kg), the dynorphin-induced increases in linear locomotion and grooming are probably mediated through opiate receptors in the brain.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004399:Dynorphins; D004723:Endorphins / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009270:Naloxone / Q000494:pharmacology*; D010446:Peptide Fragments / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D013997:Time Factors
D004723:Endorphins; D010446:Peptide Fragments; D009270:Naloxone; C026843:dynorphin (1-13); D004399:Dynorphins