Action of putative dopamine receptor agonists, TL-99, 3-PPP and RDS-127 on substantia nigra neurons.
The inhibitory actions of 3 putative dopamine receptor agonists on the firing of neurons in slices of rat substantia nigra in vitro was examined. The EPMR values for 3-PPP, RDS-127 and TL-99 were 1.11, 2.66 X 10(-3) and 2.4 X 10(-4) respectively. All 3 agonist effects were antagonized by 1 microM sulpiride.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D003864:Depression, Chemical; D018492:Dopamine Antagonists; D007189:Indans / Q000494:pharmacology*; D007192:Indenes / Q000494:pharmacology*; D008297:Male; D009281:Naphthalenes / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D013378:Substantia Nigra / Q000187:drug effects*; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*
D018492:Dopamine Antagonists; D007189:Indans; D007192:Indenes; D009281:Naphthalenes; D010880:Piperidines; D013764:Tetrahydronaphthalenes; C016893:2-(N,N-dimethylamino)-6,7-dihydroxytetralin; C035604:2-N,N-di-n-propylamino-4,7-dimethoxyindan; C026539:preclamol