The effect of topical hyperalimentation on wound healing rate and granulation tissue formation of experimental deep second degree burns in guinea-pigs.
Revital , a product containing 19 amino acids, was applied to experimental deep second degree burns in guinea-pigs for 24 days, in order to assess the effect of this form of hyperalimentation on the healing process. Silver sulphadiazine cream served as the contralateral control standard. Epithelialization was faster in the silver sulphadiazine treated burn wounds, while contraction of both tested wounds proceeded at a similar rate. Revital significantly enhanced the formation of granulation and scar tissue in this burn wound model. These observations indicate that topical wound hyperalimentation promotes granulation tissue formation of experimental deep second degree burns in guinea-pigs.
D000287:Administration, Topical; D000596:Amino Acids / Q000008:administration & dosage*; D000818:Animals; D002056:Burns / Q000503:physiopathology* / Q000628:therapy; D005260:Female; D006097:Granulation Tissue / Q000187:drug effects*; D006168:Guinea Pigs; D009747:Nutritional Physiological Phenomena; D012837:Silver Sulfadiazine / Q000008:administration & dosage; D014945:Wound Healing / Q000187:drug effects*
D000596:Amino Acids; D012837:Silver Sulfadiazine