Intramitochondrial inclusions in maturing and senescent muscle cells of rat myocardium.
Intramitochondrial myelin-like structures were found in ventricular myocardial cells of the rat heart. These inclusions were found in both the first 2 postnatal weeks and in senescent stages. The origin of such myelin-like structures could be related to an age-dependent metabolic change, specifically to an inability to oxidize long-chain fatty acids described in both periods.
D000375:Aging; D000818:Animals; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure*; D009206:Myocardium / Q000648:ultrastructure*; D051381:Rats; D013367:Submitochondrial Particles / Q000648:ultrastructure*