title: Relationship of conceptus number to the action of luteinizing hormone-antiserum in the pregnant rat.
abstract: Treatment of pregnant rats on Day 12 of pregnancy with luteinizing hormone-antiserum (LH-AS) (equine anti-bovine LH) had no effect on the maintenance of pregnancy or serum progesterone levels in rats bearing either 2 or more than 8 conceptuses. In rats with only 1 conceptus, LH-AS administration resulted in a significant decline in serum progesterone to basal levels within 24 h and all animals (n = 6) failed to maintain pregnancy. All rats with either 1, 2 or greater than 8 implantations showed no effect of normal horse serum (NHS) administration. There was no effect of LH-AS administration on serum testosterone levels, compared to NHS-treated controls.
mesh_terms: D000818:Animals; D000906:Antibodies / Q000008:administration & dosage; D005260:Female; D008098:Litter Size; D007986:Luteinizing Hormone / Q000276:immunology / Q000502:physiology*; D011247:Pregnancy; D011255:Pregnancy Maintenance; D011374:Progesterone / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000097:blood
chemical_list: D000906:Antibodies; D013739:Testosterone; D011374:Progesterone; D007986:Luteinizing Hormone