Impaired in vitro metabolism of the flukicidal agent nitroxynil by hepatic microsomal cytochrome P-450 in bovine fascioliasis.
In vitro metabolism by liver tissue of the flukicidal agent nitroxynil has been studied in cattle naturally infected with Fasciola hepatica. A dramatic impairment of the cytochrome P-450-dependent nitroxynil metabolism both in the acute and in the milder stage of the disease has been observed and this is due to a loss in the integrity and functionality of the cytochrome P-450 enzyme system. These results suggest that in bovine fascioliasis the in vivo metabolism of nitroxynil will be decreased with consequent increase of nitroxynil retention in the animal's body.
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy / Q000378:metabolism*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005210:Fasciola hepatica; D005211:Fascioliasis / Q000188:drug therapy / Q000378:metabolism / Q000662:veterinary*; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism*; D009596:Nitrophenols / Q000378:metabolism*; D009611:Nitroxinil / Q000378:metabolism* / Q000627:therapeutic use; D010084:Oxidation-Reduction
D009596:Nitrophenols; D003577:Cytochrome P-450 Enzyme System; D009611:Nitroxinil