Synthesis of pseudotrisaccharides related to ribostamycin.
The three protected sisamine derivatives 2i, 2j and 3, with a free 5-hydroxyl group, have been synthesized. Glycosylation at the 5 position with various pentofuranose derivatives yielded after deprotection of the 6a approximately i ribostamycin related aminoglycoside. These pseudotrisaccharides showed only low antibacterial activities with respect to the parent compounds.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D009844:Oligosaccharides / Q000138:chemical synthesis*; D012271:Ribostamycin / Q000138:chemical synthesis*; D014312:Trisaccharides / Q000138:chemical synthesis*
D000900:Anti-Bacterial Agents; D009844:Oligosaccharides; D014312:Trisaccharides; D012271:Ribostamycin