Bioavailability of doxycycline monohydrate. A comparison with equivalent doses of doxycycline hydrochloride.
Two derivatives of doxycycline, the monohydrate-free base and the hydrochloride salt were given orally to 12 volunteers in a crossover study. There was no difference in absorption and bioavailability between the two preparations. Secondary plasma peaks indicating reabsorption were noticed for both derivatives. Doxycycline monohydrate, proven to have a lower risk of inducing esophageal lesions, is a good alternative to the hydrochloride salt in oral treatment.
D000042:Absorption; D000328:Adult; D001682:Biological Availability; D004318:Doxycycline / Q000009:adverse effects / Q000378:metabolism*; D004339:Drug Compounding; D004341:Drug Evaluation; D004935:Esophageal Diseases / Q000139:chemically induced; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male
D004318:Doxycycline