Diaspirins of methylenecitric acid.
A series of bissalicylic esters of methylenecitric acid have been prepared and, as a probe of their potential as antisickling agents, tested for their ability to modify hemoglobin. Substantial acylation of hemoglobin was obtained with these dicarboxylate esters at 1-5 mM concentrations.
D000986:Antisickling Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D002951:Citrates / Q000138:chemical synthesis* / Q000494:pharmacology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007525:Isoelectric Focusing; D012459:Salicylates / Q000138:chemical synthesis* / Q000494:pharmacology
D000986:Antisickling Agents; D002951:Citrates; D006454:Hemoglobins; D012459:Salicylates; C041248:methylenecitric acid