Promoting effect of concanavalin A on transport of sodium cefoxitin and phenol red from rat rectal compartment.
Concanavalin A enhanced the rat rectal absorption of phenol red and cefoxitin at pH 7.4 and the uptake of cefoxitin into brush border membrane vesicles prepared from rat rectal membrane. The enhancing action of concanavalin A demonstrated a sodium ion dependency and was inhibited by the presence of 4,4'-diisothiocyano-2,2'-disulfonate stilbene and phlorizin. This inhibition suggests the involvement of the membrane protein fraction.
D000818:Animals; D002440:Cefoxitin / Q000378:metabolism; D003208:Concanavalin A / Q000494:pharmacology*; D004347:Drug Interactions; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D008871:Microvilli / Q000187:drug effects / Q000378:metabolism; D010637:Phenolsulfonphthalein / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012007:Rectum / Q000187:drug effects / Q000378:metabolism
D003208:Concanavalin A; D002440:Cefoxitin; D010637:Phenolsulfonphthalein