Growth hormone secretion of the neonatal rat pituitaries is stimulated by gamma-aminobutyric acid in vitro.
Growth hormone secretion from pituitaries of neonatal rats was stimulated by gamma-aminobutyric acid (GABA) and the GABA agonist muscimol in vitro. This response to GABA was absent after the 9th postnatal day. The stimulation of growth hormone secretion by GABA was antagonized by bicuculline-methiodide and by picrotoxin. Diazepam stimulated while baclophen had no effect on growth hormone secretion. This stimulatory GABA effect might be related to a certain developmental stage of the pituitary GABA receptors or to the lack of hypothalamic regulatory influence(s) in the newborn.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001418:Baclofen / Q000494:pharmacology; D001640:Bicuculline / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D005260:Female; D018756:GABA Antagonists; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D066298:In Vitro Techniques; D009118:Muscimol / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013331:Strychnine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D001418:Baclofen; D001640:Bicuculline; D003975:Diazepam; D018756:GABA Antagonists; D013006:Growth Hormone; D009118:Muscimol; D010852:Picrotoxin; D013331:Strychnine; D005680:gamma-Aminobutyric Acid