Alternative diaspirins for modification of hemoglobin and sickle hemoglobin.
Studies of modification of hemoglobin and of sickle hemoglobin by alternative aspirins have been extended to a series of new bis esters with a variety of substituted bridging diacids and to a group of mono esters with polar acyl groups. Rates of hydrolysis of these alternative aspirins have also been examined, and they reveal that a careful balance between stability and reactivity is essential for optimal activity. Four-carbon bridging groups have been found to be particularly effective, two of these raising the minimum gelling concentration of sickle hemoglobin by as much as 100%.
D000328:Adult; D000986:Antisickling Agents; D001241:Aspirin / Q000031:analogs & derivatives* / Q000494:pharmacology; D001952:Bridged-Ring Compounds / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006451:Hemoglobin, Sickle / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D006868:Hydrolysis; D013329:Structure-Activity Relationship
D000986:Antisickling Agents; D001952:Bridged-Ring Compounds; D006451:Hemoglobin, Sickle; D006454:Hemoglobins; D001241:Aspirin