[Sulpiride (stereoisomers, racemic) and dopamine: actions and interactions on renal excretion of hydro-saline].
Renal effects of Dopamine (DA, subpressor dosage 0.1 microgram X kg -1 X min -1) during hypotonic polyuria in moderate hydro-saline retention are variously modified by either d- or l-Sulpiride isomers. In the presence of d-Sulpiride, DA effects, such as an increase in diuresis, free water clearance (CH20) and kaliuresis are suppressed, while increases of saluresis and natriuresis are significantly blunted. In the presence of l-Sulpiride no changes are observed in both saluresis and natriuresis, while decreases occur in diuresis, CH20 and kaliuresis. The inhibitory DA effects on isosmotic sodium reabsorption as a percentage of sodium filtered load are prevented by either isomer as well. A possible role of ineffective renal vascular DA action can be involved in such defective tubular inhibition. However is also suggested a pharmacological blockade of proximal tubular specific DA receptors.
D001834:Body Water / Q000378:metabolism*; D004298:Dopamine / Q000494:pharmacology*; D004347:Drug Interactions; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D011188:Potassium / Q000378:metabolism; D011954:Receptors, Dopamine / Q000378:metabolism; D013237:Stereoisomerism; D013469:Sulpiride / Q000494:pharmacology*
D011954:Receptors, Dopamine; D013469:Sulpiride; D011188:Potassium; D004298:Dopamine
Sulpiride (stereoisomeri, racemico) e dopamina: azioni e interazioni sulla escrezione renale idro-salina.