Methylbromide: carcinogenic effects in the rat forestomach.
Methylbromide (MB) administered by oral gavage as a solution in arachis oil was carcinogenic to rats in a 90-day experiment. In 13 of 20 animals of the highest dose group, 50 mg MB/kg body wt squamous cell carcinomas of the forestomach developed. All animals of this group showed a marked diffuse hyperplasia of the epithelium of the forestomach. A less pronounced hyperplasia was observed in high and lower incidence with respectively 10 and 2 mg MB/kg body wt. The lowest dose, 0.4 mg MB/kg body wt was without effects.
D000818:Animals; D001772:Blood Cell Count; D001835:Body Weight / Q000187:drug effects; D002273:Carcinogens / Q000633:toxicity*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced* / Q000473:pathology; D004435:Eating / Q000187:drug effects; D005260:Female; D006842:Hydrocarbons, Brominated / Q000633:toxicity*; D006965:Hyperplasia / Q000139:chemically induced; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000473:pathology*; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology
D002273:Carcinogens; D006842:Hydrocarbons, Brominated; C005218:methyl bromide