[Relation of the survival of mouse hematopoietic stem cells to the interval between periodic injections of hydroxyurea].
The dependence was studied between the survival of proliferating hemopoietic stem cells (CFUs) on the interval between regular multiple injections of hydroxyurea (HU). Before HU injection mice were irradiated in a dose of 200 rad to trigger the proliferation of CFUs. The dependence obtained is resonance in character, with a maximum being attained during injections made with a 12-hour interval. Comparison with the mathematical model indicates that interval corresponding with the maximal survival should correlate with the mean time of the generation of proliferating CFUs.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D006918:Hydroxyurea / Q000008:administration & dosage*; D051379:Mice; D010507:Periodicity; D013997:Time Factors
D000970:Antineoplastic Agents; D006918:Hydroxyurea
Zavisimost' vyzhivaniia stvolovykh krovetvornykh kletok mysh ot intervala mezhdu periodicheskimi vvedeniiami oksimocheviny.