title: Arylhydroxy metabolites of cocaine in the urine of cocaine users.
abstract: The major arylhydroxy metabolite of cocaine in human urine was identified as 4'-hydroxybenzoylecgonine methyl ester by comparison of mass spectral and relative gas-liquid chromatography retention time data of metabolites in patient samples with those of the three synthesized positional isomers. The 3'-hydroxy isomer was also identified in most samples, but its concentration varied widely from sample to sample.
mesh_terms: D000328:Adult; D002849:Chromatography, Gas; D003042:Cocaine / Q000031:analogs & derivatives / Q000378:metabolism* / Q000652:urine; D005260:Female; D006801:Humans; D006900:Hydroxylation; D008297:Male; D013058:Mass Spectrometry; D019966:Substance-Related Disorders / Q000652:urine*
chemical_list: D003042:Cocaine; C040867:4'-hydroxycocaine; C040868:3'-hydroxycocaine