[Effect of trimecaine, ajmaline, stenopril and chloracizine on fluctuations in K+ currents in rat liver mitochondria].
Antianginal hypotensive preparations chloracyzin and stenopryl, antiarrhythmic aimalin as well as local anesthetic and antiarrhythmic trimekaine hydrochloride were studied for their effect on the K+ inflow and outflow rate in the rat liver mitochondria during Sr2+-induced vibrations. In spite of differences in the chemical structure and pharmacological effect, all these substances are shown to uniformly suppress ion flow vibrations in mitochondria, inhibiting K+ outflow. It is found that the inhibition of the K+ outflow rate depends on the concentration of the preparations. Activity of the studied substances as to inhibition of K+ outflow from mitochondria correlates with their pharmacologic activity.
D000083:Acetanilides / Q000494:pharmacology*; D000404:Ajmaline / Q000494:pharmacology*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D003864:Depression, Chemical; D004140:Dinitrophenols / Q000494:pharmacology; D008930:Mitochondria, Liver / Q000187:drug effects*; D010627:Phenethylamines / Q000494:pharmacology*; D010640:Phenothiazines / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014288:Trimecaine / Q000494:pharmacology*
D000083:Acetanilides; D004140:Dinitrophenols; D010627:Phenethylamines; D010640:Phenothiazines; C026894:stenopril; D000404:Ajmaline; D014288:Trimecaine; D011188:Potassium; C004584:chloracizine
Deĭstvie trimekaina, aĭmalina, stenoprila i khloratsizina na kolebaniia potokov K+ v mitokhondriiakh pecheni krys.