Effects of coronary artery disease on the aging heart: observations from cardiac catheterization.
We evaluated catheterization laboratory data from 691 individuals (219 normals and 472 coronary patients) using a computerized data file that provided several measures of cardiovascular performance in 10-year age increments. The expected increase in arterial pressure with age was noted in normals and coronary patients. Left ventricular end diastolic pressure, end diastolic volume, and end systolic volume remained constant with age but were higher in all age groups in the coronary patients. Ejection fraction showed no change with age but was lower in all age groups in patients with coronary disease. Left ventricular mass increased with age in normals and coronary patients. Cardiac index declined with age, whereas arteriovenous oxygen difference and oxygen consumption were unchanged. Age-related changes in the circulation were for the most part unaffected by the presence of coronary disease. Resting left ventricular function was not altered by age but coronary disease produced a decline in left ventricular function in all ages.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D001794:Blood Pressure; D006328:Cardiac Catheterization; D003327:Coronary Disease / Q000503:physiopathology*; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D010100:Oxygen / Q000502:physiology; D012119:Respiration; D014655:Vascular Resistance
D010100:Oxygen