title: Dose-response anesthetic effects of ketamine in the chicken.
abstract: Forty-six chickens were anesthetized with ketamine given IV at 12 dosages ranging from 1 to 160 mg/kg. The median effective dose (ED50) for greater than or equal to 15 minutes' anesthesia was 14 mg/kg. The median lethal dose (LD50) was 67.9 mg/kg. Analgesia adequate for doing major surgical operation was generally not apparent in chickens given doses less than 60 mg/kg. Side effects included muscle tremors which were unrelated to painful stimulation and flapping of wings which was common during recovery from anesthesia.
mesh_terms: D000771:Anesthesia, Intravenous / Q000662:veterinary*; D000818:Animals; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D007649:Ketamine / Q000008:administration & dosage; D007928:Lethal Dose 50
chemical_list: D007649:Ketamine