title: Use of coproantibody measurement to assess the influence of diet on local immune responses of sheep vaccinated against Haemonchus contortus.
abstract: Local antibody responses to challenge with 10,000 normal Haemonchus contortus larvae were evaluated in vaccinated and control Blackface sheep fed either a high or low protein diet. Anti-parasite antibody activity was found in faecal extracts of both vaccinated and control animals after infection. The coproantibody levels showed some correlation with abomasal mucosa antibody levels and faecal antibody activity was mostly associated with IgA. The low protein diet reduced local antibody responses in vaccinated and control sheep. However despite lower antibody levels the efficacy of vaccination was not diminished in sheep fed a low protein diet.
mesh_terms: D000018:Abomasum / Q000276:immunology; D000818:Animals; D000917:Antibody Formation; D004044:Dietary Proteins / Q000008:administration & dosage*; D005243:Feces / Q000276:immunology / Q000469:parasitology; D005260:Female; D006189:Haemonchus / Q000276:immunology* / Q000528:radiation effects; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis*; D007814:Larva / Q000276:immunology / Q000528:radiation effects; D008297:Male; D012756:Sheep / Q000276:immunology*; D014251:Trichostrongyloidea / Q000276:immunology*; D014611:Vaccination / Q000662:veterinary*; D014613:Vaccines, Attenuated / Q000276:immunology
chemical_list: D004044:Dietary Proteins; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins; D014613:Vaccines, Attenuated