title: Synthesis and antibacterial activity of some 5-nitro-3-phenyliminoindol-2(3H)-ones and their N-Mannich bases.
abstract: The antimicrobial and antifungal activities of a series of 5-nitro-3-phenyliminoindol-2(3H)-ones and their 1-piperidinomethyl analogues (N-Mannich bases) were investigated. Growth inhibition of Gram-positive bacteria was observed with little or no activity against Gram-negative bacteria. Antifungal activity was absent. The syntheses were accomplished from 5-nitroindol-2,3-dione by condensation with the appropriate aniline followed by formation of the N-Mannich base.
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D007211:Indoles / Q000138:chemical synthesis*; D007510:Isatin / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D008352:Mannich Bases / Q000138:chemical synthesis / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D007211:Indoles; D008352:Mannich Bases; D007510:Isatin