Scoliosis caused by section of dorsal spinal nerve roots.
Experimental evidence has accumulated in recent years to suggest that scoliosis can be caused by asymmetrical spinal muscle weakness due to sensorineural loss, though this suggestion has not achieved universal acceptance. The evidence is supported by histopathological observations on cases of clinical idiopathic scoliosis. A study is presented in which cynomolgus monkeys had one, two or three dorsal spinal nerve roots cut. Scoliosis developed, convex to the damaged side; its severity was dependent on the number of nerve roots cut. Section of the first lumbar dorsal spinal nerve root had a marked tendency to cause scoliosis. The study supports the view that scoliosis may be caused by asymmetrical paraspinal muscle weakness acting through loss of proprioception.
D000818:Animals; D004195:Disease Models, Animal; D008161:Lumbosacral Region; D008252:Macaca fascicularis; D011183:Postoperative Complications; D012600:Scoliosis / Q000209:etiology*; D013126:Spinal Nerve Roots / Q000601:surgery*