Inhibition of the UV induction of sister-chromatid exchanges in ICR-2A frog cells by pretreatment with gamma-rays.
Exposure of ICR-2A cells to UV induced the formation of sister-chromatid exchanges (SCEs). However, pretreatment of UV-irradiated cells with gamma-rays resulted in a reduction in the level of SCEs. This effect was observed over a range of UV fluences (1-5 J/m2) and gamma-ray doses (50-500 rad). In addition, the depression of UV-induced SCEs was greatest when the UV treatment was preformed within 3 h after gamma-irradiation. At later times the level of SCEs approached that of cells exposed only to UV.
D000818:Animals; D002460:Cell Line; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D007700:Kinetics; D011898:Ranidae; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D014466:Ultraviolet Rays