Effects of selenium-vitamin E injection on bovine polymorphonucleated leukocytes phagocytosis and killing of Staphylococcus aureus.
Phagocytosis and killing of Staphylococcus aureus by polymorphonuclear leukocytes (PMN) from 8 selenium (Se)-deficient dairy cows from Wisconsin was compared with that in 5 Se-vitamin E injected dairy cows from the same herd. There was no significant difference in the ability of the PMN to phagocytize bacteria. However, PMN of Se-vitamin E injected cows killed the phagocytized bacteria significantly (P less than 0.025) better than did PMN from Se-deficient cows. The defect in the killing capability of PMN of Se-deficient cows might be due to reduced dihydronicotinamide adenine dinucleotide phosphate concentration as a result of diminished glutathione peroxidase activity due to Se-deficiency.
D000818:Animals; D002417:Cattle / Q000276:immunology*; D002418:Cattle Diseases / Q000097:blood / Q000276:immunology; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects*; D051381:Rats; D020887:Selenious Acid; D012643:Selenium / Q000097:blood / Q000172:deficiency / Q000494:pharmacology*; D013211:Staphylococcus aureus / Q000276:immunology*; D014810:Vitamin E / Q000494:pharmacology*
D014810:Vitamin E; D005979:Glutathione Peroxidase; D020887:Selenious Acid; D012643:Selenium