Ultrastructural changes of bone marrow megakaryocytes in several types of injury.
Seventy-one dogs were used in this study. Bone marrow tissues were examined by LM and EM and the peripheral blood platelets were counted. On the basis of previous research, megakaryocytophagia in bone marrow was confirmed. It was also proved that neutrophilic granulocytes participate in the autophagocytosis reaction in the body. Megakaryocytophagia plays a major role in the elimination of degenerate megakaryocytes in the marrow. The pathological change in megakaryocytes is considered to be one of the important causes of decrease in number and impairment of function of the platelets in burn, blast injury and burn-blast combined injury.
D000818:Animals; D001343:Autophagy; D001853:Bone Marrow / Q000648:ultrastructure*; D002056:Burns / Q000473:pathology*; D004285:Dogs; D008533:Megakaryocytes / Q000648:ultrastructure*; D008854:Microscopy, Electron; D009504:Neutrophils / Q000378:metabolism / Q000648:ultrastructure; D010976:Platelet Count