Detection of exposure to mutagenic compounds in low-tar and medium-tar cigarette smokers.
A volunteer study was carried out on groups smoking low-tar (5.4 mg/cig.) and medium-tar (16.3 mg/cig.) cigarettes and on non-smokers. The number of cigarettes smoked was recorded daily throughout a 51-day study period, and the effects of smoking were measured in the beginning and after 3-week terms of smoking medium-tar or low-tar cigarettes. The parameters measured were blood carboxyhemoglobin concentration, thioethers excreted into the urine, mutagenic activity in the urine, and the frequency of sister-chromatid exchanges in blood lymphocytes. For all four parameters, the differences between the smokers and the non-smokers were significant. However, within the study design no differences could be detected between low-tar or medium-tar cigarette smoking in the biological-monitoring tests used.
D000328:Adult; D002263:Carboxyhemoglobin / Q000032:analysis; D006801:Humans; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens / Q000652:urine*; D012854:Sister Chromatid Exchange; D012907:Smoking; D013440:Sulfides / Q000652:urine
D009153:Mutagens; D013440:Sulfides; D002263:Carboxyhemoglobin