title: [Adriamycin (doxorubicin) in the combined treatment of patients with the edematous-infiltrative form of breast cancer].
abstract: Twenty-one female patients with edematous infiltrative cancer of the breast without distant metastases not given specific therapy before were treated with vincristine, adriamycin, methotrexate and irradiation of the mammary glands and regional areas in accordance with the splitted course procedure. If the positive estrogen receptors were present in the tumor tissue, the patients with preserved menstrual function and menopause of not more than 5 years were subjected to ovariectomy. The suggested induction scheme of the treatment provided pronounced objective results in 80.9 per cent of the patients. The tumor regression by less than 50 per cent was observed in 14.3 per cent of the patients. Only 1 patient had the signs of the disease progress. No threatening leukothrombopenia or cardiotoxicity signs were recorded during the treatment period. It allowed the recommending of this method for the treatment of outpatients.
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy; D003131:Combined Modality Therapy; D004317:Doxorubicin / Q000008:administration & dosage*; D004487:Edema / Q000188:drug therapy* / Q000532:radiotherapy; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D011879:Radiotherapy Dosage; D013629:Tamoxifen / Q000008:administration & dosage; D045165:Testosterone Congeners / Q000008:administration & dosage; D013997:Time Factors; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D045165:Testosterone Congeners; D013629:Tamoxifen; D014750:Vincristine; D004317:Doxorubicin; D008727:Methotrexate
vernacular_title: Adriamitsin (doksorubitsin) v kompleksnom lechenii bol'nykh s otechno-infil'trativnoĭ formoĭ raka molochnoĭ zhelezy.