Modulation of glucocorticoid effect in thymus of adrenalectomized-diabetic rat.
Cellular receptors to glucocorticoids and the effect of dexamethasone and corticosterone on 3H-uridine incorporation into the acid-insoluble fraction were studied in thymocytes from adrenalectomized-diabetic rats and adrenalectomized ones. An increase in the dissociation constant of the hormone-receptor plot was observed when adrenalectomized-diabetic animals were compared to adrenalectomized controls. Meanwhile decreasing concentrations of dexamethasone and corticosterone below receptors saturation, were less active as inhibitor of 3H-uridine incorporation into RNA by thymocytes from adrenalectomized-diabetic than from adrenalectomized ones.
D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D003345:Corticosterone / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D005260:Female; D005938:Glucocorticoids / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism*; D014529:Uridine / Q000378:metabolism
D005938:Glucocorticoids; D011965:Receptors, Glucocorticoid; D003907:Dexamethasone; D003345:Corticosterone; D014529:Uridine