Adverse drug interactions with cimetidine: competitive inhibition of monooxygenase-dependent N-demethylation of morphine.
D000818:Animals; D002927:Cimetidine / Q000009:adverse effects*; D003640:Dealkylation; D004347:Drug Interactions; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D009020:Morphine / Q000378:metabolism*; D010105:Oxygenases / Q000037:antagonists & inhibitors*; D051381:Rats
D009020:Morphine; D002927:Cimetidine; D010105:Oxygenases