title: Protection of rat gastric mucosa against ethanol injury by the new synthetic prostaglandin MDL 646.
abstract: Oral administration to fasted rats of absolute ethanol produces extensive necrotic lesions of gastric mucosa as well as a massive leakage of proteins and mucus glycoproteins into gastric lumen. When the new synthetic prostaglandin MDL 646, belonging to the PGE1 series, is administered intragastrically (2 or 10 micrograms/kg) 30 min before ethanol administration, a significant protection of rat gastric mucosa against alcohol injury is observed.
mesh_terms: D000527:Alprostadil / Q000031:analogs & derivatives*; D000818:Animals; D000897:Anti-Ulcer Agents; D000431:Ethanol / Q000633:toxicity*; D005753:Gastric Mucosa / Q000378:metabolism / Q000473:pathology*; D006023:Glycoproteins / Q000378:metabolism; D008297:Male; D009336:Necrosis; D011459:Prostaglandins E, Synthetic / Q000627:therapeutic use*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013272:Stomach Diseases / Q000139:chemically induced / Q000517:prevention & control*
chemical_list: D000897:Anti-Ulcer Agents; D006023:Glycoproteins; D011459:Prostaglandins E, Synthetic; D011506:Proteins; D000431:Ethanol; D000527:Alprostadil; C036058:mexiprostil