[Determination of the ratio of membrane-bound and free polyribosomes and of the content of thyroglobulin in these fractions in normal thyroid gland cells and in several types of thyroid diseases].
The ratio of membrane-bound and free polyribosomes in thyroid gland cells was decreased two-fold in nodular euthyroid goiter and five-fold--in Hashimoto thyroiditis; a slight increase in thyroglobulin synthesis in free polyribosomes was noted in goiter. Impairments in transfer of the translation products across membranes of rough endoplasmic reticulum may be one of the causes of deteriorations in thyroglobulin synthesis in goiters.
D000818:Animals; D002417:Cattle; D002462:Cell Membrane / Q000648:ultrastructure; D011132:Polyribosomes / Q000378:metabolism*; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism; D013954:Thyroglobulin / Q000096:biosynthesis*; D013959:Thyroid Diseases / Q000378:metabolism* / Q000473:pathology; D013961:Thyroid Gland / Q000378:metabolism* / Q000648:ultrastructure
D012333:RNA, Messenger; D013954:Thyroglobulin
Opredelenie sootnosheniia membranosviazannykh i svobodnykh poliribosom i soderzhaniia v étikh fraktsiiakh tireoglobulinovykh poliribosom v kletkakh shchitovidnoĭ zhelezy v norme i pri nekotorykh vidakh tireoidnoĭ patologii.