title: [Genome mutation yield in the cells of intact and regenerating liver of normal rats and following gamma irradiation].
abstract: A comparative study was made of spontaneous and induced polyploidy in cells of resting and regenerating rat liver. Polyploidy was shown to play a major role in the ontogenesis and during regeneration after partial hepatectomy. An essential difference was revealed in the radiation response of cells of intact and regenerating liver with respect to the yield of polyploid cells. This distinction was referred to different effectiveness of the processes of repair and fixation of radiation damages in the actively proliferating and resting cells.
mesh_terms: D000818:Animals; D004247:DNA / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D005796:Genes / Q000528:radiation effects*; D006498:Hepatectomy; D008099:Liver / Q000502:physiology / Q000528:radiation effects*; D008115:Liver Regeneration / Q000528:radiation effects*; D008297:Male; D009154:Mutation; D011123:Polyploidy; D051381:Rats; D013997:Time Factors
chemical_list: D004247:DNA
vernacular_title: Vykhod genomnykh mutatsiĭ v kletkakh intaktnoĭ i regeneriruiushcheĭ pecheni krys v norme i posle gamma-oblucheniia.