Chloramphenicol ototoxicity. A case report.
A case of bilateral profound sensori-neural hearing loss following systemic administration of chloramphenicol is reported because of its rarity. The hearing loss was gradually progressive, involving one ear; and with a repeat course of the drug, the other ear too was involved. An idiosyncratic or allergic response to previous exposure to the drug may be the cause of the toxicity. One should be careful in prescribing the drug repeatedly; when this is done, the patient must be carefully observed for possible toxic effects.
D000328:Adult; D002701:Chloramphenicol / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D034381:Hearing Loss / Q000139:chemically induced*; D006312:Hearing Loss, Bilateral / Q000139:chemically induced*; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced*; D006801:Humans; D014435:Typhoid Fever / Q000188:drug therapy
D002701:Chloramphenicol