Behavioral effects of trimethyltin in two strains of mice. II. Multiple fixed ratio, fixed interval.
Adult male C57BL/6N and BALB/c mice were trained to respond under a multiple fixed-ratio 30, fixed-interval 600-sec schedule of milk presentation. After performance had stabilized, each mouse received a single dose of trimethyltin X Cl (TMT) by ip administration. Three hours after administration, behavioral testing was started and continued at 24-hr intervals thereafter. The behavior of mice receiving 0.3 mg/kg was unaffected at 3, 27, and 51 hr after administration. Likewise, no effects were seen at 3 and 27 hr after 1 mg/kg. However, at 51 hr after administration there was a significant change in the temporal patterning of fixed-interval responding in the C57BL/6N strain, as shown by a decrease in the fixed-interval quarter-life. There was no significant change in the BALB/c strain at this dose. At 3 mg/kg the responding of both strains was greatly affected, and responding remained disrupted for at least 6 to 7 weeks. Neuropathological examination of the brains of both strains of mice showed no significant lesions (light microscopy) at 0.3 and 1 mg/kg. At 3 mg/kg, severe neuronal necrosis was observed in the fascia dentata region in both strains. Thus, in mice receiving TMT, the behavioral deficits were closely paralleled by the presence or absence of significant neuropathology.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000473:pathology; D003216:Conditioning, Operant / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005247:Feeding Behavior / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000648:ultrastructure; D011930:Reaction Time / Q000187:drug effects; D012055:Reinforcement Schedule; D013045:Species Specificity; D014220:Trialkyltin Compounds / Q000633:toxicity*; D014298:Trimethyltin Compounds / Q000633:toxicity*
D014220:Trialkyltin Compounds; D014298:Trimethyltin Compounds