title: [Lagophthalmos and posterior synechiae of the iris during treatment of leprosy with diaminodiphenylsulfone].
abstract: Four years after controlled and standardized chemotherapy with diaminodiphenylsulfone (DDS), 316 patients in the leprosarium at Khokana, Nepal were re-examined for ophthalmological findings. Patients who, 4 years earlier, had not had lagophthalmos in either eye, nor posterior synechiae of the iris, had only developed these complications in the meantime if they were suffering from DDS-resistant leprosy. New posterior synechiae of the iris were only found in patients with inactive leprosy who had already had a posterior synechia in the fellow eye four years previously. In cases of inactive leprosy there was also a tendency for existing posterior synechiae to increase. It is emphasized that the development of lagophthalmos or posterior synechiae of the iris indicates that a previously inactive leprosy may have become reactivated in spite of treatment with DDS.
mesh_terms: D000328:Adult; D003622:Dapsone / Q000009:adverse effects* / Q000627:therapeutic use; D004352:Drug Resistance, Microbial; D005141:Eyelid Diseases / Q000139:chemically induced*; D005260:Female; D006801:Humans; D007499:Iris Diseases / Q000139:chemically induced*; D007918:Leprosy / Q000188:drug therapy*; D008297:Male; D000267:Tissue Adhesions / Q000139:chemically induced
chemical_list: D003622:Dapsone
vernacular_title: Lagophthalmus und hintere Synechien der Iris bei der Behandlung der Lepra mit Diamino-diphenyl-sulfon.