title: Determination of cocaine in plasma by automated gas chromatography.
abstract: A rapid and sensitive gas chromatographic method is described for the determination of cocaine in plasma. A close structural analogue of cocaine, m-toluylecgonine methyl ester, is used as an internal standard. The simplicity of the extraction scheme and the use of an automatic sampler makes the method convenient for large numbers of samples generated in pharmacokinetic studies.
mesh_terms: D001322:Autoanalysis / Q000379:methods; D002849:Chromatography, Gas / Q000379:methods; D003042:Cocaine / Q000008:administration & dosage / Q000097:blood*; D004355:Drug Stability; D005615:Freezing; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006868:Hydrolysis; D007275:Injections, Intravenous; D007700:Kinetics
chemical_list: D003042:Cocaine