Hydrolysis of clonazepam, flunitrazepam and nitrazepam by hydrochloric acid. Identification of some additional products.
Several by-products in the hydrochloric acid hydrolysis of clonazepam, flunitrazepam and nitrazepam are isolated by a combination of TLC and HPLC. With mass and NMR spectroscopic methods the structures of the by-products are established. Some indications are given for possible modes of formation of the by-products.
D001569:Benzodiazepines / Q000032:analysis* / Q000097:blood / Q000652:urine; D001570:Benzodiazepinones / Q000032:analysis*; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D002998:Clonazepam / Q000032:analysis*; D005445:Flunitrazepam / Q000032:analysis*; D006801:Humans; D006868:Hydrolysis; D009567:Nitrazepam / Q000032:analysis*; D013057:Spectrum Analysis
D001570:Benzodiazepinones; D001569:Benzodiazepines; D002998:Clonazepam; D005445:Flunitrazepam; D009567:Nitrazepam