A new type D retrovirus isolated from macaques with an immunodeficiency syndrome.
Macaque monkeys with the recently described acquired immunodeficiency syndrome show a marked defect in T-lymphocyte function and die with opportunistic infections and lymphoproliferative abnormalities. In the study described here a new type D retrovirus was isolated from two Macaca cyclopis with this syndrome. This virus is related to, but distinct from, Mason-Pfizer monkey virus, a type D retrovirus previously isolated from a mammary tumor of a rhesus monkey (Macaca mulatta).
D000818:Animals; D002051:Burkitt Lymphoma; D002460:Cell Line; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000382:microbiology*; D008251:Macaca; D009693:Nucleic Acid Hybridization; D012190:Retroviridae / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*