title: Analysis of 90 step-sectioned cystectomized specimens of bladder cancer.
abstract: For systematic understanding of papillary superficial carcinoma and nonpapillary invasive carcinoma of the bladder 90 cystectomized specimens of transitional cell carcinoma of the bladder were analyzed by step-section. From gross and microscopic observations bladder cancer was classified into 3 types: type 1--multiple papillary superficial carcinomas with or without small areas of dysplasia or carcinoma in situ, type 2--multiple coexistent papillary and nonpapillary carcinomas with widespread dysplasia and carcinoma in situ, and type 3--solitary nonpapillary invasive carcinoma without dysplasia and carcinoma in situ. Actuarial 5-year survival rates for types 1 to 3 were 97, 50 and 17 per cent, respectively. Although this classification is somewhat overlapping and there is a bias that basic data are obtained from the cystectomized specimens, we believe that such an analysis is necessary for considering the histogenesis and progression of human bladder cancer.
mesh_terms: D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D002291:Carcinoma, Papillary / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D002295:Carcinoma, Transitional Cell / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D004848:Epithelium / Q000473:pathology; D006801:Humans; D006965:Hyperplasia; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011379:Prognosis; D001743:Urinary Bladder / Q000601:surgery; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery