title: Specific antibodies to porcine zona pellucida detected by quantitative radioimmunoassay in both fertile and infertile women.
abstract: The specific radioimmunoassay system was developed for the titration of the antibodies to porcine zona pellucida (ZP) in human sera by using 125I-labeled purified porcine ZP as antigen, which is known to have cross-reactivity with human ZP. The antibodies in human sera were detected in 3 of 11 (27%) women with unexplained infertility, in 16 of 48 (33%) amenorrheic patients, in 4 of 12 (33%) fertile women, and in 3 of 10 (30%) men. Moreover, antibody titers in infertile women were no higher than those in fertile women and in men. These results seem to suggest that the antibodies in human sera that cross-react with porcine ZP may not be an important factor in causing infertility in women.
mesh_terms: D000818:Animals; D000906:Antibodies / Q000032:analysis*; D000941:Antigens; D003429:Cross Reactions; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000276:immunology*; D010063:Ovum / Q000276:immunology*; D011817:Rabbits / Q000276:immunology; D011863:Radioimmunoassay; D013552:Swine / Q000276:immunology*; D015044:Zona Pellucida / Q000276:immunology*
chemical_list: D000906:Antibodies; D000941:Antigens