Salmonella/microsome mutagenicity of 1-nitropyrene-2-ol, a nitropyrene phenol formed in the photolysis of 1-nitropyrene.
1-Nitropyrene-2-ol is not detectably mutagenic in the Salmonella test in the absence of mammalian activation. It is activated by the rat liver microsome-containing preparation S9 and gives a mutagenic response similar to that of benzo(a)pyrene.
D000818:Animals; D001711:Biotransformation; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000138:chemical synthesis; D009154:Mutation; D010782:Photolysis; D011721:Pyrenes / Q000138:chemical synthesis / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012475:Salmonella / Q000187:drug effects / Q000235:genetics*
D009153:Mutagens; D011721:Pyrenes; C041064:1-nitropyrene-2-ol; C032668:1-nitropyrene