Exercise-induced changes in the in vivo distribution of 111In-labelled platelets.
In order to throw some light on the mechanisms underlying exercise-induced thrombocytosis, we investigated 15 healthy persons subjected to short-term vigorous pedalling on a bicycle ergometer 1 d after injection of autologous 111In-labelled platelets. Scintigraphic studies during the post-exercise period showed the spleen to be the major platelet-releasing organ. There was, however, a considerable interindividual variability manifested as signs of a contributing platelet release from the lungs in some cases and of deposition of a surplus of released platelets in the liver of others. Our results also seem to be compatible with the existence of an intravascular marginal platelet pool.
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000502:physiology*; D005260:Female; D006400:Hematocrit; D006801:Humans; D007204:Indium; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D011868:Radioisotopes; D013156:Splenectomy; D013997:Time Factors
D011868:Radioisotopes; D007204:Indium