Prenatal diagnosis of skeletal dysplasia by real-time ultrasound.
A control group of 165 normal pregnant women between 16 and 22 weeks' gestation was studied by real-time ultrasound scan to establish the normal length of the femur, tibia-fibula complex, humerus, and radius-ulna complex. A group of 32 pregnant women at risk for various types of fetal skeletal dysplasia were studied during the same gestational period. In three cases a structural defect was diagnosed, resulting in elective abortion. Conditions for optimal prenatal diagnosis of skeletal dysplasias are discussed.
D000028:Abortion, Induced; D000328:Adult; D001846:Bone Development; D001848:Bone Diseases, Developmental / Q000151:congenital* / Q000175:diagnosis / Q000453:epidemiology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009426:Netherlands; D011247:Pregnancy; D011296:Prenatal Diagnosis; D014463:Ultrasonography