title: Evaluation of the in vivo efficacy of a new vaginal contraceptive agent in stumptailed macaques.
abstract: The effect of precoital vaginal placement of three spermicidal formulations on postcoitally recovered vaginal and cervical spermatozoa was compared. Periovulatory stumptailed macaque monkeys were administered intravaginally 1 ml of Ramses Contraceptive Vaginal Jelly (C. Schmid Products Company, Little Fall, NJ), or a pluronic gel formulation containing 0, 0.1, or 1.0% of a new spermicidal compound, RS-37367. All spermicide-containing formulations reduced the motility of both vaginal and cervical sperm, compared with the gel containing no spermicide. The 1.0% RS-37367 formulation was particularly effective. No motile spermatozoa were recovered from either location, and only 0.5% of the numbers of cervical spermatozoa recovered in control animals were recoverable from this treatment group (P less than 0.0003). The formulation containing 0.1% RS-37367 appeared to be bioequivalent to the Ramses formulation containing 5% nonoxynol-9. These in vivo results support previous in vitro comparisons in which RS-37367 was estimated to be 50 times as potent a spermatostatic agent as nonoxynol-9.
mesh_terms: D000818:Animals; D002582:Cervix Mucus / Q000502:physiology; D003271:Contraceptive Agents, Female / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D008251:Macaca; D008297:Male; D013081:Sperm Motility / Q000187:drug effects; D013089:Spermatocidal Agents / Q000494:pharmacology; D013094:Spermatozoa / Q000187:drug effects; D014622:Vaginal Creams, Foams, and Jellies / Q000494:pharmacology*
chemical_list: D003271:Contraceptive Agents, Female; D007093:Imidazoles; D013089:Spermatocidal Agents; D014622:Vaginal Creams, Foams, and Jellies; C038684:1-(2-(2,4-dichlorobenzyloxy)-n-octyl)imidazole oxalate