title: TAG antagonises the central cardiovascular effects of taurine.
abstract: The taurine antagonist TAG was examined for its blocking activity towards the central cardiovascular effects of taurine and muscimol. Intracerebroventricular (i.c.v.) injections of taurine (1-1000 micrograms/kg) and muscimol (0.1-3 micrograms/kg) in the anesthetised cat led to hypotension and bradycardia. Pretreatment with TAG (1 mg/kg i.c.v.) antagonised the blood pressure effects of taurine. The selectivity of this antagonism is discussed since TAG also shifted to the right the blood pressure dose-response curve obtained with muscimol.
mesh_terms: D000818:Animals; D001581:Benzothiadiazines / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000502:physiology; D002415:Cats; D004305:Dose-Response Relationship, Drug; D006339:Heart Rate / Q000187:drug effects*; D009118:Muscimol / Q000037:antagonists & inhibitors; D013654:Taurine / Q000037:antagonists & inhibitors*
chemical_list: D001581:Benzothiadiazines; D013654:Taurine; D009118:Muscimol; C032946:6-aminomethyl-3-methyl-4H-1,2,4-benzothiadiazine 1,1-dioxide