Carcinogenesis in rats by some hydroxylated acyclic nitrosamines.
A comparison was made of the carcinogenic effectiveness of five hydroxylated nitrosodialkylamines given to female F344 rats in drinking water. Nitroso-2,3-dihydroxypropyl-2-hydroxypropylamine was the most potent carcinogen among those examined, and induced almost exclusively tumors of the upper gastrointestinal tract. Considerably less potent was nitrosobis-(2-hydroxypropyl)amine, which also induced mainly tumors of the esophagus, although several animals also had tumors of the nasal cavity. Nitrosodiethanolamine was weaker again, and induced a high incidence of hepatocellular carcinomas. Nitroso-2-hydroxypropylethanolamine, which can be considered a hybrid of nitrosodiethanolamine, and the bis-hydroxypropyl compound, induced both esophageal tumors and hepatocellular carcinomas, together with some liver angiosarcomas; it appeared to lie in potency between the two symmetrical compounds. In contrast, nitroso-2,3-dihydroxypropylethanolamine was a very weak carcinogen, having little life-shortening effect; it induced hepatocellular carcinomas in only a small number of animals, together with some neoplastic nodules.
D000818:Animals; D004938:Esophageal Neoplasms / Q000139:chemically induced; D005260:Female; D008113:Liver Neoplasms / Q000139:chemically induced; D008175:Lung Neoplasms / Q000139:chemically induced; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology*; D009602:Nitrosamines / Q000633:toxicity*; D051381:Rats; D011916:Rats, Inbred F344; D013274:Stomach Neoplasms / Q000139:chemically induced; D013329:Structure-Activity Relationship; D014062:Tongue Neoplasms / Q000139:chemically induced
D009602:Nitrosamines