[Microbiological aspects of the elaboration of effective antibiotic therapy of bacterial lesions of the biliary tract].
Sensitivity of staphylococci of different origin to desoxycholic, cholic and choleic bile acids was studied. On this basis a system for differentiation of the staphylococcal bilicultures from the staphylococcal cultures of the other origin was developed. It was shown that the bile and bile acids potentiated the activity of some antibiotics and inhibited the action of the others. Such a strictly individual property of synergism or antagonism of the cholates and antibiotics depended on the properties of the causative agent and the type of the antibiotics and bile acids. The results of the study provided the development of a method for determination of the biliculture antibiotic sensitivity on a medium containing the patient's bile. The antibiotic which induced the maximum inhibition of the bacterial growth in the presence of the patient's bile should be recommended for the treatment of this patient.
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001424:Bacterial Infections / Q000188:drug therapy* / Q000382:microbiology; D001646:Bile / Q000382:microbiology; D001647:Bile Acids and Salts / Q000494:pharmacology; D001659:Biliary Tract / Q000382:microbiology; D001660:Biliary Tract Diseases / Q000188:drug therapy* / Q000382:microbiology; D004347:Drug Interactions; D006801:Humans; D008826:Microbial Sensitivity Tests
D000900:Anti-Bacterial Agents; D001647:Bile Acids and Salts
Mikrobiologicheskie aspekty razrabotki ratsional'noĭ antibiotikoterapii bakterial'nykh porazheniĭ zhelchevyvodiashchikh puteĭ.