title: Circulating anticoagulant in CREST syndrome.
abstract: We report the discovery of a circulating anticoagulant in a patient suffering from CREST syndrome. The patient was first seen with a microangiopathic haemolytic anaemia which led to the diagnosis of the CREST syndrome. Several months later, prior to a cataract operation, a routine coagulation screen (prothrombin time and partial thromboplastin time) was abnormal. Investigation showed the presence of a circulating anticoagulant as well as a decrease in several clotting factors, principally factor VIII C.
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000097:blood*; D002114:Calcinosis / Q000150:complications*; D004947:Esophagus / Q000503:physiopathology; D005260:Female; D006801:Humans; D010528:Peristalsis; D011517:Prothrombin Time; D011928:Raynaud Disease / Q000150:complications*; D013577:Syndrome; D013684:Telangiectasis / Q000150:complications
chemical_list: D000925:Anticoagulants