title: Hepatocyte taurocholic acid uptake in the regression of ethinyl estradiol cholestasis. Preliminary results.
abstract: Taurocholic uptake in ethinyl estradiol cholestatic rats is significantly lower than in untreated rats. In the days following treatment withdrawal there is only a slow increase in uptake, which is still statistically lower than normal at the 11th day. Taurocholic acid uptake behaves in a different way from biliary flow and the amount of excreted bile acids. The diversity could be attributed to a different behaviour of bile acid carriers at the sinusoidal and biliary membranes in the hepatocyte or to a normalisation of bile acid carriers and Na+,K+,-ATPase activity at different times.
mesh_terms: D000818:Animals; D002779:Cholestasis / Q000139:chemically induced* / Q000378:metabolism; D004997:Ethinyl Estradiol; D005260:Female; D008099:Liver / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D013656:Taurocholic Acid / Q000378:metabolism*
chemical_list: D004997:Ethinyl Estradiol; D013656:Taurocholic Acid