title: Bileaflet, tilting disc and porcine aortic valve substitutes: in vivo hydrodynamic characteristics.
abstract: The St. Jude valve is a new bileaflet disc cardiac valve prosthesis designed to avoid some of the hemodynamic drawbacks of other prostheses. The in vivo flow characteristics of the St. Jude aortic valve (42 patients) were studied and compared with those of three other commonly used aortic prostheses. Björk-Shiley (12 patients), Hancock (27 patients) and Carpentier-Edwards (15 patients). The studies, performed 24 to 48 hours after surgery, included measurements at rest and during augmentation of valve flow by infusion of isoproterenol. The mean performance index for valves of all sizes is higher for the St. Jude than for either porcine valve, both at rest and during isoproterenol infusion (p less than 0.05). Utilizing data both at rest and with isoproterenol, the relation of valve flow and mean systolic gradient for each size of St. Jude valve (19 to 25 mm) indicates the occurrence of small increases in gradient (5.3 to 8.2 mm Hg) as valve flow increases, ranging from 161 to 436 ml/systolic X min. A direct comparison of valve flow and gradient data for all size 25 and 23 mm prostheses at rest indicates a tendency for a lower mean systolic gradient in both mechanical valves than in either porcine valve (p = 0.07). With isoproterenol augmentation of valve flow in 25 mm valves, the gradient is less (p less than 0.05), and the effective orifice area and performance index are larger (p less than 0.05) for the St. Jude than for either porcine valve.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000328:Adult; D000368:Aged; D001021:Aortic Valve; D001705:Bioprosthesis; D002302:Cardiac Output; D006350:Heart Valve Prosthesis; D006801:Humans; D007545:Isoproterenol; D008875:Middle Aged; D011474:Prosthesis Design; D012212:Rheology; D013599:Systole
chemical_list: D007545:Isoproterenol