title: Resistant rheumatoid arthritis. What to do when conservative therapy doesn't work.
abstract: A significant number of patients with rheumatoid arthritis fail to obtain satisfactory disease suppression with conservative therapy. What other means of treatment are available? In what order should they be introduced? What are the potential side effects? The authors address these questions in the following review of management of resistant rheumatoid arthritis.
mesh_terms: D000962:Antimalarials / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003603:Cytotoxins / Q000627:therapeutic use; D004351:Drug Resistance; D005938:Glucocorticoids / Q000627:therapeutic use; D006046:Gold / Q000008:administration & dosage; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007263:Infusions, Parenteral; D008727:Methotrexate / Q000627:therapeutic use; D010396:Penicillamine / Q000008:administration & dosage
chemical_list: D000962:Antimalarials; D003603:Cytotoxins; D005938:Glucocorticoids; D007166:Immunosuppressive Agents; D006046:Gold; D010396:Penicillamine; D008727:Methotrexate