title: Combined immunodeficiency preceding chronic lymphocytic leukemia.
abstract: A 66-year-old female, suffering from recurrent infections of the respiratory tract, developed a severe hypogammaglobulinemia and an impaired cell mediated immunity in combination with abdominal lymphadenopathy and splenomegaly. Considering a lymphoid malignancy, an explorative laparotomy was performed. No malignancy could be established. After a follow-up of 2 years a diagnosis of chronic lymphocytic leukemia could be made. The onset of hypogammaglobulinemia 2 years before the development of chronic lymphocytic leukemia is not yet reported in the literature.
mesh_terms: D000361:Agammaglobulinemia / Q000150:complications*; D000368:Aged; D001854:Bone Marrow Cells; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D007945:Leukemia, Lymphoid / Q000150:complications / Q000209:etiology*; D008199:Lymphadenitis / Q000209:etiology; D012882:Skin Tests; D013163:Splenomegaly / Q000209:etiology