title: Short stature and pubertal delay in male adolescents with cystic fibrosis. Androgen treatment.
abstract: We evaluated the growth rate and pubertal status of 54 adolescent and young adult men with cystic fibrosis and assessed the efficacy of short-term androgen therapy in promoting growth and pubertal development. Thirty-nine percent were below the fifth percentile in height and 8/28 (28%) between the ages of 14 and 18 had delays in pubertal development. Five male adolescents aged 13 years 8 months to 18 years 3 months were treated with testosterone and their conditions were prospectively evaluated. Growth rate increased from an entry mean of 2.2 cm/yr (range 0 to 4 cm/yr) to 7.2 cm/yr (3 to 10 cm/yr). We conclude that a brief course of testosterone appears to be a safe, effective means of improving growth rate in male adolescents with cystic fibrosis with delay of puberty.
mesh_terms: D000293:Adolescent; D000328:Adult; D000886:Anthropometry; D001827:Body Height; D002648:Child; D003550:Cystic Fibrosis / Q000150:complications*; D005069:Evaluation Studies as Topic; D006128:Growth; D006130:Growth Disorders / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010555:Personality Inventory; D011446:Prospective Studies; D011628:Puberty, Delayed / Q000188:drug therapy* / Q000209:etiology / Q000523:psychology; D012189:Retrospective Studies; D012737:Sex Factors; D013739:Testosterone / Q000627:therapeutic use*
chemical_list: D013739:Testosterone