Species difference in sensitivity to the diabetogenic action of triphenyltin hydroxide.
The sensitivity to the diabetogenic action of triphenyltin hydroxide (TPTOH) was investigated in 5 species of experimental animals. A single oral administration of TPTOH produced marked hyperglycemia and triglyceridemia in rabbits and hamsters, but no evidence of diabetes was found in mice, rats and guinea-pigs. No morphological abnormality was observed in islet tissue from TPTOH-treated hamsters.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D006224:Cricetinae; D005659:Fungicides, Industrial; D006168:Guinea Pigs; D006943:Hyperglycemia / Q000139:chemically induced*; D008297:Male; D008647:Mesocricetus; D009947:Organotin Compounds / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013045:Species Specificity; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D005659:Fungicides, Industrial; D009947:Organotin Compounds; D014280:Triglycerides; C007567:triphenyltin hydroxide