Amplification of the c-myc oncogene in one of five human breast carcinoma cell lines.
The c-myc oncogene was not rearranged in any of five different human breast carcinoma cell lines examined. A 10-fold amplification and an elevated expression of the oncogene were detected in one of these cell lines, and the four other lines expressed low or undetectable levels of c-myc transcripts. Thus, c-myc amplification and elevated expression may be found only in a minority of human breast carcinomas.
D001943:Breast Neoplasms / Q000235:genetics*; D002460:Cell Line; D004587:Electrophoresis, Agar Gel; D005260:Female; D005784:Gene Amplification; D005786:Gene Expression Regulation; D006801:Humans; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D014158:Transcription, Genetic