Nifedipine and the conditioning response.
The effect of nifedipine (N) on conditioning was studied in 14 healthy sedentary men, aged 20 to 34 years. Subjects were ranked according to maximal oxygen consumption (VO2 max), paired, and 1 of each pair randomly assigned to take N, 20 mg, or placebo (C) 3 times daily. Exercise conditioning was 5 times/week for 6 weeks at greater than 85% of maximal heart rate for both groups. Adherence to exercise was 81% for the N and 82% for the C group. After training, the N group improved VO2 max from 41.4 +/- 1.4 to 51.6 +/- 2.0 ml/kg/min (p less than 0.05) and exercise time from 22 +/- 1 to 28 +/- 1 minutes (p less than 0.05). Heart rate (HR) at rest and the product of heart rate and systolic blood pressure both decreased (p less than 0.05): 70 +/- 6 to 55 +/- 4 beats/min; 9,300 +/- 900 to 6,800 +/- 700 beats/min X mm Hg. In the C group, VO2 max increased from 43.2 +/- 2.5 to 49.9 +/- 2.5 ml/kg/min (p less than 0.05); exercise duration improved from 24 +/- 2 to 29 +/- 2 minutes (p less than 0.05), and the rate-pressure product at rest decreased from 8,000 +/- 400 to 6,700 +/- 400 (p less than 0.05). Differences between N and C were not significant. Thus, N, unlike propranolol, does not inhibit the response to exercise conditioning.
D000222:Adaptation, Physiological / Q000187:drug effects*; D000328:Adult; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects; D005082:Physical Exertion; D010919:Placebos; D011674:Pulse / Q000187:drug effects; D013223:Statistics as Topic; D013997:Time Factors
D010919:Placebos; D009543:Nifedipine