[Nonspecific chemotactic response of macrophages, lymph node status and prognosis in operable cancers of the lung and breast].
Using a technique developed in our department, we studied the macrophage chemotactic response "in vivo" to a non-specific stimulus in 125 patients with operable lung cancer and 56 patients with operable breast cancer. The response was compared to that of 45 normal controls and 54 patients with metastatic cancer. The results of the preoperative test were correlated with lymph node status determined postoperatively by pathologic examination and also with prognosis. The follow-up on these patients has now reached 60 months. The chemotaxis test has revealed subgroups with different prognoses among both the N+ and N- groups. Patients with N- status (both lung and breast) and a strong preoperative chemotactic response had a very high recurrence rate, above that of N+ patients. Among the N+ patients a subgroup with very limited lymph node involvement and a strong chemotactic response had a significantly better prognosis that the N group as a whole.
D001943:Breast Neoplasms / Q000276:immunology*; D002464:Cell Migration Inhibition; D002633:Chemotaxis; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000276:immunology*; D008207:Lymphatic Metastasis / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D011300:Preoperative Care; D011379:Prognosis
Réponse chimiotactique non spécifique des macrophages, statut ganglionnaire et pronostic dans les cancers opérables du poumon et du sein.