title: Characterization of the Changuinola serogroup viruses (Reoviridae: Orbivirus).
abstract: The antigenic, biological, and chemical properties of 24 selected Changuinola serogroup viruses were examined. The viruses tested were chloroform-resistant, and they were lethal to newborn hamsters after intracerebral inoculation. The prototype Changuinola virus strain (BT-436) replicated in mosquito and sandfly cell cultures. In complement-fixation tests, the viruses were broadly cross-reacting and indistinguishable; but by neutralization test at least 12 distinct serotypes were identified, and by PAGE of double-stranded RNA 22 distinct profiles were found. These data suggest that the Changuinola serogroup may be comprised of a large number of genetically different viruses. A brief review of the natural history of Changuinola serogroup viruses is also given.
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D006224:Cricetinae; D003429:Cross Reactions; D007313:Insecta / Q000382:microbiology; D012330:RNA, Double-Stranded / Q000032:analysis; D012087:Reoviridae / Q000145:classification* / Q000276:immunology / Q000472:pathogenicity
chemical_list: D000956:Antigens, Viral; D012330:RNA, Double-Stranded