In vivo effects of hymenoxon on glucose metabolism in rat brain.
Hymenoxon inhibition of brain hexokinase resulted in inhibition of glucose utilization evidenced by a decrease in pyruvate and the accumulation of free glucose in the brains of the in vivo treated rats. Inhibition of cerebral energy processes, resulting from inhibition of glycolysis, eventuated the coma and death of one rat at 13 hr. It also accounted for the depression, observed to increase with hymenoxon exposure time, in the treated rats. The increased sulfhydryl group concentration in the brains of the treated rats suggested that increased concentration of reduced glutathione may have resulted from a decrease in its oxidation caused by hymenoxon interaction with sulfhydryl of endogenous brain constituents.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D006019:Glycolysis / Q000187:drug effects; D006593:Hexokinase / Q000032:analysis; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012717:Sesquiterpenes / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000378:metabolism
D012717:Sesquiterpenes; D013438:Sulfhydryl Compounds; C015288:hymenovin; D006593:Hexokinase; D005978:Glutathione; D005947:Glucose