A sequential study of plasma histidine-rich glycoprotein and plasminogen in patients with acute myocardial infarction and deep vein thrombosis.
In a prospective study of deep vein thrombosis (DVT), detected by the Tc-plasmin test, in 34 patients with acute myocardial infarction sequential determinations were made in plasma by immunologic methods of histidine-rich glycoprotein (HRG) and total plasminogen and the concentrations of free plasminogen calculated. Mean plasma HRG concentrations were consistently higher in the group of patients, in which Tc-plasmin scanning had revealed the existence of DVT. The effect of HRG caused the level of free plasminogen to be only 50-60% of the level of total plasminogen. Fluctuations of HRG caused only minor changes in free plasminogen concentrations. Our data suggest that HRG acts as a weak, negative acute phase reactant.
D000368:Aged; D001798:Blood Proteins; D006801:Humans; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000150:complications; D010958:Plasminogen / Q000032:analysis*; D011446:Prospective Studies; D011506:Proteins; D013924:Thrombophlebitis / Q000097:blood* / Q000209:etiology; D000099053:Histidine-Rich Glycoprotein
D001798:Blood Proteins; D011506:Proteins; D000099053:Histidine-Rich Glycoprotein; D010958:Plasminogen