title: Tubular dysfunction in systemic lupus erythematosus.
abstract: 20 patients with systemic lupus erythematosus undergoing renal biopsies had their tubular function assessed by maximal concentrating ability, maximal urinary acidification and fractional urinary excretion of beta 2-microglobulin. 80% of patients showed disturbances in one or more of the parameters tested with fractional beta 2-microglobulin excretion being most frequently abnormal. No correlation was found between the histological changes and functional disturbances.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007671:Kidney Concentrating Ability; D007677:Kidney Function Tests; D007684:Kidney Tubules / Q000473:pathology / Q000503:physiopathology*; D007687:Kidney Tubules, Proximal / Q000503:physiopathology; D008180:Lupus Erythematosus, Systemic / Q000503:physiopathology* / Q000652:urine; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000503:physiopathology / Q000652:urine