Production of fumigaclavine A by Aspergillus tamarii Kita.
Aspergillus tamarii Kita. isolated from seeds of Paspalum scrobiculatum L. is found to produce ergot alkaloids in submerged culture. The culture filtrate and mycelium are observed to contain 0.125 mg/mL and 1.2 mg/g (dry weight) total alkaloids consisting of 86.5 and 91.3% fumigaclavine A, respectively. The identification of the compound was confirmed by high-performance liquid chromatography, ultraviolet, infrared, and mass spectrophotometry analyses. This is the first report of the production of ergot alkaloid by this fungus. The possible role of fumigaclavine A as a mycotoxin is discussed.
D001230:Aspergillus / Q000032:analysis / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004873:Ergolines / Q000032:analysis* / Q000096:biosynthesis / Q000302:isolation & purification; D004876:Ergot Alkaloids / Q000096:biosynthesis* / Q000302:isolation & purification; D013058:Mass Spectrometry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D004873:Ergolines; D004876:Ergot Alkaloids; C010453:isofumigaclavine A