Changes in the composition of two molecular species of ethanolamine plasmalogen in normal human myelin during development.
Changes in the ratio of two molecular species of ethanolamine plasmalogen, PI-LE-1 and PI-PE-2, of human central nervous system myelin during development were measured by a TLC procedure. The ratio was found to decrease sharply with age up to 6 months as a result of an increase in the amount of PI-PE-2, believed to be a unique myelin lipid with 18:1 chains in both positions of the glycerol. The ratio continued to decrease gradually with age and did not reach the adult level until an age of 17 years.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001921:Brain / Q000254:growth & development*; D001923:Brain Chemistry; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D009186:Myelin Sheath / Q000032:analysis*; D010955:Plasmalogens / Q000032:analysis*
D010955:Plasmalogens; C020791:phosphatidal ethanolamines