cis-Unsaturated fatty acids uncouple mitochondria and stimulate glycolysis in intact lymphocytes.
In intact lymphocytes, linoleic acid acts as a typical mitochondrial uncoupler: it substantially decreases the mitochondrial membrane potential and the cellular ATP level, while stimulating oxygen consumption and glycolysis. Under these conditions the inhibition of cellular functions by linoleic acid cannot be attributed to its postulated effects on lipid domains in the plasma membrane.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D006019:Glycolysis / Q000187:drug effects*; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D014475:Uncoupling Agents / Q000494:pharmacology*
D008041:Linoleic Acids; D014475:Uncoupling Agents; D000255:Adenosine Triphosphate; D019787:Linoleic Acid