Aortic valve homografts in the surgical treatment of complex cardiac malformations.
From April of 1968 to March of 1983, the surgical treatment of complex congenital cardiac malformations requiring an extracardiac conduit for their correction was performed with aortic valve homografts or aortic valved homograft conduits sterilized and preserved in our hospital. Our experience concerns 93 patients in whom a total of 103 aortic valve homografts were implanted. Ages of the patients ranged from 7 months to 36 years (mean 11.6 years). The aortic valve homografts were used from the right atrium to the pulmonary arteries or right ventricle (right atrium-dependent conduit), from the venous ventricle to the pulmonary arteries (ventricle-dependent conduit), or in the pulmonary orifice and in the superior and/or inferior venae cavae. There were 25 early and nine late deaths (36.5%), none of them related to the aortic valve homograft. The clinical follow-up of the 59 survivors (1 month to 15 years, mean 4.3 years) evidenced neither dysfunction of the aortic valve homograft nor thromboembolism or hemolysis; 93% of the patients are in New York Heart Association Class I or II. Control cardiac catheterization in 53 patients evidenced a pressure gradient in only 14 ventricle-dependent conduits. In seven patients with serial control catheterizations after 5 to 10 years, the pressure gradient had not increased.
D000293:Adolescent; D000328:Adult; D001021:Aortic Valve / Q000637:transplantation*; D006328:Cardiac Catheterization; D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D005080:Exercise Test; D005260:Female; D006330:Heart Defects, Congenital / Q000601:surgery*; D006461:Hemolysis; D006801:Humans; D007223:Infant; D008297:Male; D011184:Postoperative Period; D012086:Reoperation