Enhancement of paracetamol induced hepatotoxicity by prior treatment with carboxymethylcellulose.
This study was undertaken to determine if interactions of toxicological significance might occur during treatment of mice with paracetamol (P) and carboxymethylcellulose (CMC). P (300 mg/kg) administration induced only slight hepatic morphologic changes and lowered hepatic reduced glutathione (GSH) to 40% of the level in controls, when measured 1 hour after treatment. Intraperitoneal pretreatment with CMC (1% in NaC1, 20 ml/kg), significantly decreased GSH concentration (to 19% of controls) and severely enhanced hepatic injury. Such an interaction is of considerable significance since both CMC and P are widely used substances in experimental pharmacology and clinical practice.
D000082:Acetaminophen / Q000633:toxicity*; D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000503:physiopathology*; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives*; D051379:Mice; D013997:Time Factors
D000082:Acetaminophen; D008747:Methylcellulose; D005978:Glutathione; D002266:Carboxymethylcellulose Sodium