Successful small bowel allotransplantation in dogs with cyclosporine and prednisone.
Twelve dogs had transplantation of almost the entire small intestine in the orthotopic location; immunosuppression was with cyclosporine and prednisone. Half the dogs had survival of at least one month, and a third lived for at least four months. Two of the animals are still living after 550 and 555 days. Maintenance of nutrition, and absorption of D-xylose and fat were better than in control animals with an iatrogenic short gut syndrome, but distinctly worse than that of normal dogs.
D000818:Animals; D001835:Body Weight; D003524:Cyclosporins / Q000008:administration & dosage*; D004285:Dogs; D005260:Female; D006084:Graft Rejection / Q000187:drug effects; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000473:pathology; D007421:Intestine, Small / Q000473:pathology / Q000637:transplantation*; D008297:Male; D011241:Prednisone / Q000008:administration & dosage*; D012778:Short Bowel Syndrome / Q000209:etiology / Q000503:physiopathology; D014184:Transplantation, Homologous / Q000009:adverse effects / Q000379:methods* / Q000401:mortality
D003524:Cyclosporins; D011241:Prednisone