Effect of taurocholate pretreatment on the biliary excretion of exogenous organic anions in rats.
The effect of pretreatment with taurocholate (1.12 mmol/kg per os twice daily for two days) on the biliary excretion of exogenous organic anions (rose bengal, bromcresol green, unconjugated and conjugated bromsulphthalein, eosine and amaranth) has been investigated in rats. Bromsulphthalein was excreted at a higher rate into the bile when its conjugation with glutathione was prevented by diethyl maleate (0.7 ml/kg i.p.). On the other hand, when conjugated bromsulphthalein was given intravenously, the taurocholate pretreatment failed to significantly enhance its biliary excretion rate. The changes found after taurocholate pretreatment in the biliary excretion of rose bengal and bromcresol green were similar to those observed during the excretion of unconjugated bromsulphthalein. However, in the biliary excretion of eosine and amaranth no increase was found following taurocholate pretreatment. The results indicate that taurocholate pretreatment does not exert a uniform stimulatory effect on the biliary excretion of exogenous organic anions.
D000818:Animals; D000838:Anions / Q000378:metabolism*; D001646:Bile / Q000378:metabolism*; D004396:Coloring Agents / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013656:Taurocholic Acid / Q000494:pharmacology*; D013997:Time Factors
D000838:Anions; D004396:Coloring Agents; D013656:Taurocholic Acid