[Naloxone and endotoxic shock: a wonder drug?].
Naloxone clorhidrate was administered intravenously to 15 patients with endotoxic shock and refractary hypotension, following meningococcal sepsis. Doses used were between 0.01-0.2 mg/kg. Three patients (two of them with moderate shock) showed an increase in sistolic arterial pressure, which was maintained and above 20 mm/Hg. Among the rest of them (except one with severe shock) naloxone action was non-existent in nine cases, or with short action and without answer to next doses in other three. Eleven patients died. A blood pressure increase was maintained only in two of the four survivors. Usefulness of naloxone in this kind of patients is not clear. Presence in endotoxin shock of a variety of refractory factors besides beta endorphins, greatly limits therapeutic efficiency of this drug.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004723:Endorphins / Q000037:antagonists & inhibitors; D006801:Humans; D007022:Hypotension / Q000188:drug therapy; D007223:Infant; D008589:Meningococcal Infections / Q000150:complications; D009270:Naloxone / Q000494:pharmacology / Q000627:therapeutic use*; D012772:Shock, Septic / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology
D004723:Endorphins; D009270:Naloxone
Naloxona y "shock" endotóxico: una droga maravillosa?