Molecular genetics of lipoprotein disorders.
These types of studies lay the foundation for understanding the human apolipoproteins at the genetic level. In addition, through a few specific examples, we have already shown evidence at the DNA level that lesions in apolipoprotein genes can play a role in human atherosclerosis. This work is in its infancy, but we hope it will have a major impact on our ability to understand genetic susceptibility to atherosclerosis in the general population.
D001053:Apolipoproteins / Q000097:blood / Q000235:genetics; D001057:Apolipoproteins E; D001161:Arteriosclerosis / Q000235:genetics; D002874:Chromosome Mapping; D003001:Cloning, Molecular / Q000379:methods; D005815:Genetic Code; D006801:Humans; D008052:Lipid Metabolism, Inborn Errors / Q000235:genetics*; D008074:Lipoproteins / Q000235:genetics* / Q000378:metabolism; D009693:Nucleic Acid Hybridization
D001053:Apolipoproteins; D001057:Apolipoproteins E; D008074:Lipoproteins