Effects of prazosin on fertility of male rats.
Silastic rods containing 25% or 50% prazosin HCl were inserted adjacent to the epididymis of rats. Silastic collars containing 25% prazosin HCl were placed around the vas deferens of rats. Treated males were infertile or subfertile for 6-9 weeks after insertion of these rods or collars. The number of spermatozoa observed in the vaginal smears was reduced. It is concluded that the antifertility effect of prazosin results mainly from inhibition of ejaculation.
D000818:Animals; D003692:Delayed-Action Preparations; D004542:Ejaculation / Q000187:drug effects; D004822:Epididymis / Q000187:drug effects; D005298:Fertility / Q000187:drug effects*; D008297:Male; D011224:Prazosin / Q000008:administration & dosage / Q000494:pharmacology*; D011799:Quinazolines / Q000494:pharmacology*; D051381:Rats; D013081:Sperm Motility / Q000187:drug effects; D014649:Vas Deferens / Q000187:drug effects
D003692:Delayed-Action Preparations; D011799:Quinazolines; D011224:Prazosin