title: Effect of a diet low in saturated fatty acids on plasma lipids, lipoproteins, and HDL subfractions.
abstract: The effect on serum high density lipoprotein subfractions of a low fat diet with a high ratio of polyunsaturated-to-saturated fatty acids was studied in 38 middle-aged volunteers (19 men and 19 women) in North Karelia, Finland. The mean serum HDL2 cholesterol decreased from 32 +/- 2 mg/dl (mean +/- SE) to 28 +/- 2 mg/dl (p less than 0.001) during the experimental diet and returned to 33 +/- 2 mg/dl (p less than 0.001) after a return to the original diet. No changes were observed in the concentration of HDL3 cholesterol. A highly significant decrease was observed in serum apoprotein A-I concentration, but not in apoprotein A-II concentration during the experimental diet. It is concluded that a low-fat, high-P/S ratio diet lowers LDL and HDL2 cholesterol in healthy volunteers, but does not influence the level of HDL3 subfraction.
mesh_terms: D001059:Apoproteins / Q000097:blood; D003327:Coronary Disease / Q000453:epidemiology / Q000209:etiology; D004041:Dietary Fats / Q000008:administration & dosage*; D005231:Fatty Acids, Unsaturated / Q000097:blood; D005260:Female; D005387:Finland; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged
chemical_list: D001059:Apoproteins; D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D008055:Lipids; D008074:Lipoproteins; D008075:Lipoproteins, HDL