[Experimental studies on the effect of perfluorochemicals in tumor irradiation].
The effects of radiation therapy with Fluosol-DA on rat mammary tumors were studied. The tissue oxygen tension values of tumors in breathing mixed gas (5% carbon dioxide and 95% oxygen) with Fluosol-DA (25 ml/kg, i.v.) were significantly higher than those in room air without Fluosol-DA. The rats were divided into three groups: Group I received Fluosol-DA but no irradiation, Group II was treated with 1000 rads of irradiation using 60Co without Fluosol-DA in room air and Group III received the same irradiation and Fluosol-DA in breathing mixed gas. In the latter group we observed a prolongation of the survival time and suppression of the tumor growth.
D000818:Animals; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D005466:Fluorocarbons / Q000494:pharmacology*; D006895:Hydroxyethyl Starch Derivatives; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology / Q000532:radiotherapy*; D008748:Methylcholanthrene; D009368:Neoplasm Transplantation; D010100:Oxygen / Q000502:physiology; D010313:Partial Pressure; D051381:Rats; D011919:Rats, Inbred Strains
D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; D008748:Methylcholanthrene; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; D010100:Oxygen