Anthelmintic effect of febantel/praziquantel paste in dogs and cats.
A paste formulation of 3.4% febantel and 0.34% praziquantel was given in soft food at a rate of 0.29 g/kg of body weight, once daily for 3 days to dogs and cats. Eleven of 12 dogs were naturally infected with Ancylostoma caninum, 10 with Trichuris vulpis, 2 with Toxocara canis, 5 with Taenia sp, and 3 with Dirofilaria immitis. Ten of 11 cats were naturally infected with Toxocara cati, 2 with Ancylostoma tubaeforme, 3 with Taenia sp, 5 with Capillaria aerophila, and 1 with Paragonimus kellicotti. Efficacy was 100% for the removal of A caninum, T canis, and Taenia sp and 99.9% in clearance of T vulpis in dogs, and 100% in removal of A tubaeforme, T cati, and Taenia sp in cats. In dogs, Dirofilaria appeared unaffected, and in cats, there was no apparent effect on Capillaria or on Paragonimus. The paste formulation given in soft food was well tolerated and without observable adverse effects.
D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D002590:Cestode Infections / Q000188:drug therapy / Q000662:veterinary*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004338:Drug Combinations / Q000008:administration & dosage; D005260:Female; D006146:Guanidines / Q000008:administration & dosage*; D007411:Intestinal Diseases, Parasitic / Q000188:drug therapy / Q000662:veterinary*; D007546:Isoquinolines / Q000008:administration & dosage*; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D009824:Ointments; D011223:Praziquantel / Q000008:administration & dosage*
D000871:Anthelmintics; D004338:Drug Combinations; D006146:Guanidines; D007546:Isoquinolines; D009824:Ointments; C040536:febantel-praziquantel paste; D011223:Praziquantel; C017309:febantel