title: [Circadian and seasonal characteristics of the reaction of the liver to the administration of bilignost].
abstract: It has been shown in experiments on female rats that there are circadian and seasonal modulations in the liver reaction to bilignost administration. The most copious bile secretion was observed in the morning and evening hours in summer and in the evening hours in winter. The minimal liver sensitivity to bilignost was found in the summer group animals. It is suggested that rhythmic activity of the hypothalamohypophyseal-adrenal system underlies the changes in liver sensitivity to bilignost.
mesh_terms: D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D002940:Circadian Rhythm / Q000187:drug effects*; D003287:Contrast Media / Q000494:pharmacology*; D005260:Female; D007458:Iodipamide / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects*; D051381:Rats; D012621:Seasons; D012636:Secretory Rate / Q000187:drug effects
chemical_list: D003287:Contrast Media; D007458:Iodipamide
vernacular_title: Sutochnye i sezonnye osobennosti reaktsii pecheni na vvedenie bilignosta.