Aspartate aminotransferase activity in fiber tracts of the rat brain.
Activity of aspartate aminotransferase, an enzyme which catalyzes the interconversion of the excitatory transmitter candidates, glutamate and aspartate, has been measured in fiber tracts of rat, with an emphasis on sensory and motor systems of the brain. Most tracts had significantly higher activities than the cholinergic facial nerve root, consistent with the possibility that a component of aspartate aminotransferase activity might serve as a marker for neurons using glutamate and/or aspartate as neurotransmitter. Highest activity was in the auditory nerve root. On the other hand, a close correlation was found between aspartate aminotransferase and malate dehydrogenase activities in the fiber tracts, raising the question whether aspartate aminotransferase activity may be more closely related to energy metabolism than to transmitter metabolism.
D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism*; D001921:Brain / Q000201:enzymology*; D003391:Cranial Nerves / Q000201:enzymology; D007700:Kinetics; D008291:Malate Dehydrogenase / Q000378:metabolism; D009412:Nerve Fibers / Q000201:enzymology*; D009474:Neurons / Q000201:enzymology; D051381:Rats; D014018:Tissue Distribution
D008291:Malate Dehydrogenase; D001219:Aspartate Aminotransferases