title: Dose response of topical carbamylcholine chloride (carbachol) in normotensive and early glaucomatous beagles.
abstract: Single-dose loading with a placebo (0.5% methylcellulose) and 0.75%, 1.5%, 2.25%, or 3% carbamylcholine chloride (carbachol) was evaluated in normotensive and glaucomatous Beagles to determine dose response. The 4 carbachol concentrations significantly (P less than 0.05) lowered intraocular pressure and reduced pupil size in the normotensive and early glaucomatous Beagles at most time intervals as compared with base-line values, nontreated fellow eyes, and placebo-treated eyes. There were no significant (P less than 0.24) effects on intraocular pressure or pupil size by unilateral carbachol instillations as compared with base-line values or placebo-treated eyes.
mesh_terms: D000287:Administration, Topical; D000818:Animals; D002217:Carbachol / Q000008:administration & dosage*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy / Q000662:veterinary*; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D011680:Pupil / Q000187:drug effects
chemical_list: D002217:Carbachol