title: Correlates of reperfusion ventricular fibrillation in dogs.
abstract: To elucidate determinants of reperfusion ventricular fibrillation (VF), regional myocardial blood flow, ATP, creatine phosphate (CP), heart rate and blood pressure were compared in 2 groups of anesthetized dogs: those that fibrillated spontaneously upon release of a 15-minute coronary artery occlusion (VF group, n = 8) and those that did not fibrillate when reperfused (No VF group, n = 27). Arterial pressure and heart rate before and during coronary artery occlusion were similar in both groups. Ischemic endo- and epicardial ATP values, measured at the end of the occlusion period, were reduced approximately 20% of nonischemic values in both groups. In contrast, CP (nmol . mg protein-1) within the ischemic zone was significantly lower in the VF group in both the epicardium (14.3 +/- 1.6 in the VF group vs 22.8 +/- 2.5 in the No VF group, p less than 0.01) and the endocardium (9.0 +/- 2.0 in the VF group vs 18.7 +/- 1.8 in the No VF group, p less than 0.01). Furthermore, epi- and endocardial regional myocardial blood flow in the center of the ischemic zone during occlusion was significantly lower in VF dogs than in No VF dogs. Epicardial flow was 0.06 +/- 0.03 ml X min-1 X g-1 in VF dogs vs 0.44 +/- 0.06 in No VF dogs (p less than 0.001) and endocardial flow was 0.03 +/- 0.02 ml X min-1 X g-1 in VF dogs vs 0.23 +/- 0.04 ml X min-1 X g-1 in No VF dogs (p less than 0.001).(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000255:Adenosine Triphosphate / Q000032:analysis; D000818:Animals; D001794:Blood Pressure; D003326:Coronary Circulation; D003327:Coronary Disease / Q000150:complications; D004285:Dogs; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D010725:Phosphocreatine / Q000032:analysis; D012189:Retrospective Studies; D013997:Time Factors; D014693:Ventricular Fibrillation / Q000209:etiology* / Q000503:physiopathology
chemical_list: D010725:Phosphocreatine; D000255:Adenosine Triphosphate