Plasma levels of trazodone: methodology and applications.
A sensitive (to 5.0 ng/ml) and specific method for analysis of the antidepressant trazodone is described. The method utilizes gas-liquid chromatography with nitrogen-phosphorus detection. Applicability of the method is demonstrated by (1) a pharmacokinetic study in a normal volunteer who received 50 mg trazodone orally and (2) steady-state plasma level determinations of 2 patients receiving trazodone in the treatment of depression.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D002849:Chromatography, Gas / Q000379:methods; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D010879:Piperazines / Q000378:metabolism*; D014196:Trazodone / Q000097:blood / Q000378:metabolism*
D010879:Piperazines; D014196:Trazodone