Sympathomimetic activity of mazindol on rat anococcygeus muscle and vas deferens.
Mazindol contracted the isolated anococcygeus muscle of the rat. This effect was prevented by pretreatment with reserpine and antagonized by phentolamine but not by atropine, cocaine, hexamethonium, methysergide or promethazine. The drug potentiated the contractile response of the rat anococcygeus to noradrenaline and field stimulation and released tritium from the rat vas deferens and anococcygeus preloaded with [3H]-noradrenaline. The release of radioactivity was unaffected by incubation of the tissue in calcium free or high potassium (60 mM) solution.
D000818:Animals; D004558:Electric Stimulation; D066298:In Vitro Techniques; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008454:Mazindol / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009132:Muscles / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats; D012007:Rectum / Q000187:drug effects; D012110:Reserpine / Q000494:pharmacology; D013566:Sympathomimetics; D014649:Vas Deferens / Q000187:drug effects
D007211:Indoles; D013566:Sympathomimetics; D012110:Reserpine; D008454:Mazindol; D009638:Norepinephrine; D010646:Phentolamine