title: Transcutaneous oxygen tension in selection of amputation level.
abstract: The utility of transcutaneous oxygen tension measurements in selection of a reliable amputation level was evaluated. Measurements were made at the proposed level of amputation in 37 patients, 22 of whom underwent major limb amputation and in 15 amputation was confined to the forefoot or toes. In patients with successful amputation healing, mean transcutaneous oxygen tension on the anterior skin surface was 50 +/- 8 mm Hg (index 0.79 +/- 0.1 mm Hg). In contrast, patients with failure of healing had a mean transcutaneous oxygen tension of 22 +/- 16 mm Hg (index 0.32 +/- 0.19 mm Hg) (p less than 0.001). Measurements on the posterior or plantar skin surface and posteroanterior differences provided even greater separation between success and failure groups, with no overlap of transcutaneous oxygen tension values or index. Transcutaneous oxygen tension measurement is easily obtained and noninvasive, and can be applied to all patients irrespective of Doppler signals, noncompressible vessels, or painful lesions. Transcutaneous oxygen tension appears to predict successful healing with accuracy, and should be a useful addition to clinical judgment in selection of optimal amputation level.
mesh_terms: D000328:Adult; D000368:Aged; D000671:Amputation, Surgical / Q000379:methods*; D001157:Arterial Occlusive Diseases / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000032:analysis*; D010313:Partial Pressure; D012867:Skin / Q000098:blood supply; D014945:Wound Healing
chemical_list: D010100:Oxygen