title: Single base deletion in the vasopressin gene is the cause of diabetes insipidus in Brattleboro rats.
abstract: In rats with hereditary hypothalamic diabetes insipidus (Brattleboro rats) the gene for the vasopressin precursor lacks a single G residue in the protein-coding region. The mutation gives rise to an open reading frame predicting a hormone precursor having a different C-terminus.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002872:Chromosome Deletion; D003919:Diabetes Insipidus / Q000235:genetics*; D005796:Genes; D007031:Hypothalamus / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D009154:Mutation; D009693:Nucleic Acid Hybridization; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics; D011817:Rabbits; D051381:Rats; D011910:Rats, Brattleboro / Q000235:genetics*; D011922:Rats, Mutant Strains / Q000235:genetics*; D012156:Reticulocytes / Q000378:metabolism; D014667:Vasopressins / Q000235:genetics*
chemical_list: D012333:RNA, Messenger; D014667:Vasopressins