Structural relevance of adsorbed aminosugars on polycarbonate - antithrombogenicity.
The effects of glucosamine, galactosamine, and mannosamine on platelet adhesion and coagulation induced by an artificial surface were investigated. Glucosamine and galactosamine showed both antiplatelet and anticoagulant effects, but in case of mannosamine none of the above effects was found significant. The three analogs studied were having the same molecular weight and common molecular structure, however from our preliminary observations it could be suggested, that the spatial arrangement of functional groups in the glucopyranose ring at C2, C4 positions were important for it's activity.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001792:Blood Platelets / Q000187:drug effects; D002417:Cattle; D005688:Galactosamine / Q000494:pharmacology*; D005944:Glucosamine / Q000494:pharmacology*; D006595:Hexosamines / Q000494:pharmacology*; D066298:In Vitro Techniques; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011076:Polycarboxylate Cement; D013329:Structure-Activity Relationship; D013499:Surface Properties
D006595:Hexosamines; D011076:Polycarboxylate Cement; C005506:polycarbonate; C008322:mannosamine; D005688:Galactosamine; D005944:Glucosamine