Mother-infant prothrombin precursor status at birth.
Previous work from this laboratory has suggested there is a risk of hemorrhagic disease of the newborn (HDNB) in approximately one-third of term neonates, presumably as a result of vitamin K deficiency. Using the same assay for PIVKA (protein induced by vitamin K absence, prothrombin precursor), we studied 46 normal mother-infant pairs at term to investigate the relationship between neonatal and maternal PIVKA status. PIVKA was found in 13 infants (28%) and in seven mothers (15%). Maternal PIVKA status correlated with infant status (p less than 0.03). These data suggest that fetal vitamin K deficiency and risk of HDNB may be a consequence of maternal deficiency of the vitamin.
D000328:Adult; D015415:Biomarkers; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D049590:Postpartum Period; D011247:Pregnancy; D011498:Protein Precursors / Q000097:blood*; D011516:Prothrombin / Q000097:blood*; D012306:Risk; D014812:Vitamin K / Q000627:therapeutic use; D014813:Vitamin K Deficiency / Q000097:blood / Q000188:drug therapy; D006475:Vitamin K Deficiency Bleeding / Q000209:etiology
D015415:Biomarkers; D011498:Protein Precursors; D014812:Vitamin K; C008208:acarboxyprothrombin; D011516:Prothrombin