Cerebral blood flow in the newborn lamb with polycythemia and hyperviscosity.
We measured hematocrit, whole blood viscosity, arterial oxygen content, and cerebral blood flow in seven newborn lambs in which polycythemia and hyperviscosity were induced by partial exchange transfusion with packed red blood cells from a donor lamb. After the exchange transfusion, the hematocrit, whole blood viscosity, and arterial oxygen content were significantly elevated, whereas cerebral blood flow was reduced from baseline measurements. Sodium nitrite was then infused to reduce the arterial oxygen content to baseline values while the hematocrit and viscosity remained elevated. Under this condition, cerebral blood flow returned to baseline values. Oxygen delivery to the brain remained constant throughout the study. These results indicate that the reduction of cerebral blood flow in neonatal polycythemia and hyperviscosity is a physiologic response to increased arterial oxygen content and not a result of hyperviscosity.
D000818:Animals; D000831:Animals, Newborn; D001158:Arteries; D001794:Blood Pressure; D001809:Blood Viscosity; D002560:Cerebrovascular Circulation; D010100:Oxygen / Q000097:blood*; D011086:Polycythemia / Q000097:blood* / Q000503:physiopathology; D012756:Sheep
D010100:Oxygen