title: Single unit responses in the cochlear nucleus of the deaf quivering mouse.
abstract: Mice homozygous for the autosomal recessive gene quivering do not have a classical Preyer reflex and appear to be deaf. Round window recordings including both cochlear microphonics and compound action potentials failed to reveal any abnormality. However, auditory-evoked potentials recorded from the inferior colliculus (IC) are small with long latencies, and the thresholds are at least 50 dB higher than those recorded in controls. This suggests that the auditory deficit arises in the auditory pathway between the cochlear nerve and IC and underlines the need for a description of the functioning of the cochlear nucleus (CN). Single units were recorded extracellularly from the CN in 9 mutants (qv/qv) and 11 control animals (+/qv, or +/+) in the age range 60-120 days. The spike response pattern in mutant animals was broadly similar to that in the controls: a sustained response with monotonic rate-intensity functions. In addition the mean Q10dB for units in the mutants was similar to that of the controls. However, in mutants the group mean threshold at the characteristic frequency was higher and the latency to the first evoked spike at 20 dB above threshold was longer than in controls. Some unit responses in the mutants were similar to those of the controls. Nevertheless, in the quivering mouse, evidence now exists of single unit dysfunction in the cochlear nucleus.
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D003055:Cochlear Microphonic Potentials; D003056:Cochlear Nerve / Q000002:abnormalities / Q000503:physiopathology*; D003638:Deafness / Q000151:congenital / Q000503:physiopathology*; D005072:Evoked Potentials, Auditory; D051379:Mice; D008817:Mice, Mutant Strains