Pseudomembranous colitis with recurring diarrhoea and prolonged persistence of Clostridium difficile in a 10-year-old girl.
A 10-year-old girl developed, after treatment with amyxocillin, a clinically and sigmoidoscopically apparent pseudomembranous colitis with positive Clostridium difficile stool culture. Treatment with vancomycin resulted in rapid clinical cure, but there was a relapse of diarrhoea and reappearance of C. difficile, with no pseudomembranous colitis, within one month. Clinical symptoms subsided spontaneously but C. difficile persisted for 2 more months in the stools. This case reflects three different aspects of C. difficile infection in one child: pseudomembranous colitis, ordinary diarrhoea, and symptomless carrier state.
D000658:Amoxicillin / Q000009:adverse effects*; D002353:Carrier State; D002648:Child; D003013:Clostridium / Q000302:isolation & purification; D003015:Clostridium Infections / Q000188:drug therapy / Q000209:etiology*; D003967:Diarrhea / Q000188:drug therapy / Q000209:etiology*; D004761:Enterocolitis, Pseudomembranous / Q000188:drug therapy / Q000209:etiology*; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D012008:Recurrence; D014640:Vancomycin / Q000627:therapeutic use
D014640:Vancomycin; D000658:Amoxicillin