Sensitization potential of benzotriazole.
Predictive guinea pig sensitization studies have been performed with commercial and purified 1H-benzotriazole. In only 3 animals, induced and challenged according to the maximization protocol with more than 100 times the normal use concentration, were slight erythemas elicited with the commercial grade of benzotriazole. The optimization test with commercial and purified materials, as well as the maximization test with the purified material, was negative. We conclude that benzotriazole has a very low sensitization potential.
D000818:Animals; D003877:Dermatitis, Contact / Q000209:etiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D007428:Intradermal Tests; D008297:Male; D010328:Patch Tests; D014230:Triazoles / Q000633:toxicity*
D014230:Triazoles; C012771:benzotriazole