title: Biological action of inosine analogs in Leishmania and Trypanosoma spp.
abstract: Previous investigations have suggested that inosine analogs would be good models for the development of chemotherapeutic agents active against pathogenic hemoflagellates. We have systematically modified the five-membered heterocyclic ring of six inosine analogs and tested them for their antiprotozoal activities and toxicity to a mammalian cell line. All six analogs were very active against the three protozoan pathogens Leishmania donovani, Trypanosoma cruzi, and Trypanosoma gambiense. Two of the six, 9-deazainosine and allopurinol ribonucleoside, had very little toxicity for mouse L cells and offer promise as potential chemotherapeutic agents.
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D007288:Inosine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D007739:L Cells; D007891:Leishmania / Q000187:drug effects*; D051379:Mice; D014344:Trypanocidal Agents / Q000633:toxicity
chemical_list: D000981:Antiprotozoal Agents; D014344:Trypanocidal Agents; D007288:Inosine