Experimental study on the pulmonary absorption and excretion of toluene.
Three exposure levels of toluene were inhaled by dogs for 1 h. Toluene concentrations in expired air, arterial blood and venous blood were repeatedly measured. Absorptions of toluene within one hour of exposure were 25, 56 and 74 mg/kg at 700, 1500 and 2000 ppm respectively (absorption ratio = 27%). The cumulative excretion one hour after exposure was 63% of the absorped material at all three exposure levels. Multiple regression analyses were performed to interconnect the independent variables.
D000042:Absorption; D000818:Animals; D004285:Dogs; D008168:Lung / Q000378:metabolism*; D013997:Time Factors; D014050:Toluene / Q000097:blood / Q000378:metabolism*
D014050:Toluene