The influence of propranolol, metoprolol, and mepindolol on mucociliary clearance in coronary heart disease patients without pulmonary disease.
The effect of a beta-receptor blockade on the mucociliary clearance was studied in 24 patients without pulmonary disease but with coronary heart disease. No deterioration of mucociliary clearance was recorded under medication with 2 X 50 mg metoprolol or 2 X 2.5 mg mepindolol per day. In contrast, mucociliary clearance deteriorated significantly under medication with 2 X 40 mg propranolol.
D002923:Cilia / Q000187:drug effects; D003327:Coronary Disease / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008168:Lung / Q000187:drug effects*; D008171:Lung Diseases / Q000503:physiopathology; D008297:Male; D008790:Metoprolol / Q000494:pharmacology*; D008875:Middle Aged; D009092:Mucous Membrane / Q000187:drug effects; D010869:Pindolol / Q000031:analogs & derivatives* / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology*
C015340:mepindolol; D011433:Propranolol; D010869:Pindolol; D008790:Metoprolol