title: Caffeine pretreatment: enhancement and attenuation of d-amphetamine-induced activity.
abstract: Caffeine pretreatment was studied for its effects on d-amphetamine-induced locomotor activity. Caffeine (30 mg/kg) was given either simultaneously with or at one of several intervals (0.5, 1.5, 4.5, 12, and 13.5 hours) before d-amphetamine (1.5 mg/kg). Enhancement of d-amphetamine activity occurred with simultaneous and 30 min caffeine pretreatment. However, when given 12 or 13.5 hours before d-amphetamine, caffeine diminished the activity, measured in stabilimeter cages. Several doses of caffeine (7.5, 15, 30, and 60 mg/kg) were given in multiple treatments ending 12 hours before d-amphetamine (1.5 mg/kg) to determine the effective doses for attenuation of d-amphetamine-induced activity. Only 30 and 60 mg caffeine doses reduced d-amphetamine activity while also interfering with body weight gain.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002110:Caffeine / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats
chemical_list: D002110:Caffeine; D003913:Dextroamphetamine