Experimental antitumor activity of 5'-nor-anhydrovinblastine navelbine.
We have found that navelbine, a new semi-synthetic Vinca alkaloid analogue, is as active as vincristine on implanted murine tumors. It has a low cross-resistance with vincristine and vindesine.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity; D001932:Brain Neoplasms / Q000188:drug therapy; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D004351:Drug Resistance; D007928:Lethal Dose 50; D007939:Leukemia L1210 / Q000188:drug therapy; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D009368:Neoplasm Transplantation; D013329:Structure-Activity Relationship; D014747:Vinblastine / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D014748:Vinca Alkaloids / Q000627:therapeutic use; D000077235:Vinorelbine
D000970:Antineoplastic Agents; D014748:Vinca Alkaloids; D014747:Vinblastine; D000077235:Vinorelbine