The effect of sodium diethanolamine dithiocarbamate on distribution and excretion of Cd in rats drinking Cd-containing water.
The effect of sodium diethanolamine dithiocarbamate (DEDTC) on the distribution and excretion of cadmium was studied in three sets of rats whose drinking water contained cadmium at three different concentrations (5, 10 and 50 mg Cd.l-1) for a period of three months. DEDTC administration (500 mg.kg-1, ip) in all exposed groups significantly increased the biliary excretion of cadmium. With the exception of animals drinking water containing the lowest concentration of CD (5 mg.l-1) the urinary excretion was also increased.
D000818:Animals; D000931:Antidotes / Q000494:pharmacology*; D001646:Bile / Q000378:metabolism; D002104:Cadmium / Q000097:blood / Q000378:metabolism*; D004050:Ditiocarb / Q000031:analogs & derivatives*; D005260:Female; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013859:Thiocarbamates / Q000494:pharmacology*; D014018:Tissue Distribution; D014867:Water
D000931:Antidotes; D013859:Thiocarbamates; D002104:Cadmium; D014867:Water; D004050:Ditiocarb; C039353:dihydroxyethyldithiocarbamate