A model for adhesion formation by thermal injury in the abdominal cavity of the mouse.
An experimental model for inducing peritoneal adhesions in mice is described. Measurable thermal trauma can be inflicted by the application of a heated metal object, for a given lapse of time, to the surface of a section of mouse intestine. Parameters of temperature, area and application time were so manipulated as to obtain adhesions in only 70-75% of treated mice. It is maintained that this model can enable better evaluation of various prophylactic means and also the detection of exacerbating agents.
D000818:Animals; D002056:Burns / Q000150:complications / Q000662:veterinary*; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D051379:Mice; D010532:Peritoneal Diseases / Q000209:etiology / Q000662:veterinary*; D012376:Rodent Diseases / Q000209:etiology*; D013997:Time Factors; D000267:Tissue Adhesions / Q000209:etiology / Q000662:veterinary*