The organ uptake of intravenously administered colloidal particles can be altered using a non-ionic surfactant (Poloxamer 338).
Small polystyrene particles coated with a high Mr non-ionic surfactant (Poloxamer 338) are diverted from the reticuloendothelial system of the liver and spleen to other tissue sites. These results are discussed in terms of the adsorption of the Poloxamer to the particle surface and the implications for drug targeting.
D000818:Animals; D003102:Colloids; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism; D012157:Mononuclear Phagocyte System / Q000378:metabolism*; D011060:Poloxalene / Q000494:pharmacology*; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011817:Rabbits; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
D003102:Colloids; D011092:Polyethylene Glycols; D011060:Poloxalene