Role of portal and splenic vein shunts and impaired hepatic extraction in the elevated serum bile acids in liver cirrhosis.
To study the mechanism for the elevation of serum bile acids in liver cirrhosis, bile acid concentrations were measured in the portal, superior mesenteric, and splenic veins, using percutaneous transhepatic catheterization, and compared with those of peripheral veins in 41 patients with mild to moderately advanced cirrhosis. The demonstrated gradient of bile acid concentration was superior mesenteric vein greater than portal vein greater than peripheral vein nearly equal to splenic vein, suggesting that the superior mesenteric vein is the main route of transport for the intestinally absorbed bile acids. Bile acid concentrations in peripheral vein were correlated with the measured portal and splenic vein shunt indexes. The ursodeoxycholic acid oral tolerance test carried out in 10 patients during portal vein catheterization demonstrated that hepatic extraction of this bile acid was correlated with indocyanine green clearance and that it was inversely correlated with portal vein shunt index. These findings are consistent with the view that distorted hepatic blood flow has a significant role in elevating serum bile acid, at least in patients with moderately advanced liver cirrhosis.
D000293:Adolescent; D000328:Adult; D001647:Bile Acids and Salts / Q000097:blood*; D002404:Catheterization; D003840:Deoxycholic Acid / Q000031:analogs & derivatives*; D005215:Fasting; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008102:Liver Circulation / Q000187:drug effects; D008103:Liver Cirrhosis / Q000097:blood*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D011168:Portal System / Q000503:physiopathology*; D011170:Portasystemic Shunt, Surgical; D013162:Splenic Vein / Q000503:physiopathology*; D014580:Ursodeoxycholic Acid
D001647:Bile Acids and Salts; D003840:Deoxycholic Acid; D014580:Ursodeoxycholic Acid