[Effect of neurotensin and (DTr11)-neurotensin on the secretory function of the pancreas].
In chronic experiments on dogs, administration of neurotensin into cerebral structures (hypothalamus, caudate nucleus) or into the blood flow exerted the same effect: enhancement of the pancreas secretory function, depending on the dosage of the i.v. administration. In contrast, peripheral administration of neurotensin analogue: the DTr11-neurotensin inhibited the pancreas secretory function. Administration of the DTr11-neurotensin into the cerebral structures increased the secretory activity of the pancreas. The hypothalamus and the caudate nucleus seem to have receptors sensitive to neurotensin and DTr11-neurotensin.
D000818:Animals; D001931:Brain Mapping; D002421:Caudate Nucleus / Q000187:drug effects*; D004285:Dogs; D007031:Hypothalamus / Q000187:drug effects*; D008297:Male; D008845:Microinjections; D009496:Neurotensin / Q000008:administration & dosage / Q000494:pharmacology*; D010179:Pancreas / Q000378:metabolism*; D010189:Pancreatic Juice / Q000378:metabolism*
D009496:Neurotensin
Deĭstvie neĭrotenzina i (DTr11)-neĭrotenzina na sekretornuiu funktsiiu podzheludochnoĭ zhelezy.