Influence of zinc, D-penicillamine and oxygen on poisoning with Amanita phalloides. Zinc accelerates liver regeneration and prevents the depletion of brain noradrenaline caused by the mushroom.
Pretreatment with zinc aspartate increased the survival rate of mice poisoned with a lyophilisate from the mushroom Amanita phalloides (APL). In the livers of the zinc-treated animals, confluent necrosis was cleared earlier. Zinc also prevented the reduction of brain noradrenaline caused by the mushroom as well as the rise of brain dopamine and brain weight. D-Penicillamine also protected against the lethal effects of APL. The survival afforded by zinc pretreatment was marginally ameliorated by additional oxygenation.
D000545:Amanita; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D004298:Dopamine / Q000378:metabolism; D005260:Female; D007928:Lethal Dose 50; D008099:Liver / Q000473:pathology; D008115:Liver Regeneration / Q000187:drug effects; D051379:Mice; D009145:Mushroom Poisoning / Q000188:drug therapy* / Q000473:pathology; D009638:Norepinephrine / Q000378:metabolism; D010102:Oxygen Inhalation Therapy; D010396:Penicillamine / Q000627:therapeutic use*; D015032:Zinc / Q000627:therapeutic use*
D010396:Penicillamine; D015032:Zinc; D004298:Dopamine; D009638:Norepinephrine