Excisional biopsy in the selective management of T1 glottic cancer: a three-year follow-up study.
Transoral excisional biopsy has been used in the evaluation and management of 103 T1 glottic cancers. A 3-year follow-up on these patients indicates that excisional biopsy unequivocally established the diagnosis and stage of the disease and that it is adequate treatment for micro and mini squamous cell cancers of the glottis in which the margins of excision are clear. Excisional biopsy with positive margins and larger T1 tumors establishes the absolute need for radiotherapy. Excisional biopsy is ideal for the diagnosis and management of verrucous carcinoma and spindle cell carcinoma. Recurrent/residual squamous cell carcinoma after radiotherapy should be explored by excisional biopsy which may be curative or will establish the need for partial or total laryngectomy. The appropriate use of excisional biopsy in the selective management of early T1 glottic cancers requires attention to detail by the surgeon and the pathologist and sound clinical judgment.
D001706:Biopsy / Q000009:adverse effects / Q000379:methods*; D002277:Carcinoma / Q000175:diagnosis / Q000601:surgery; D002291:Carcinoma, Papillary / Q000175:diagnosis / Q000601:surgery; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis / Q000601:surgery; D003365:Costs and Cost Analysis; D005500:Follow-Up Studies; D005931:Glottis; D006801:Humans; D007822:Laryngeal Neoplasms / Q000175:diagnosis / Q000191:economics / Q000401:mortality / Q000473:pathology / Q000601:surgery*; D007828:Laryngoscopy; D009364:Neoplasm Recurrence, Local; D014831:Voice