title: Pre- and post-operative changes in serum immunoglobulin level in neurosurgical patients.
abstract: 46 patients treated by operative neurosurgery for spontaneous subarachnoid haemorrhage, intracranial tumour and spinal diseases were studied. Levels of circulating immunoglobulin and complement were measured pre-operatively and serially in the first 10 post-operative days. Prior to operation immunoglobulin levels in all categories of patients were distributed normally. However, immediately post-operatively IgG and IgM fell sharply. Conversely IgA rose in a marked manner and C3 levels showed a gradual increase. Later, antibody levels tended to return to normal.
mesh_terms: D003176:Complement C3 / Q000032:analysis; D005260:Female; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000097:blood / Q000601:surgery*; D011184:Postoperative Period; D011300:Preoperative Care
chemical_list: D003176:Complement C3; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M