title: Aging of the erythrocyte. XIX. Decrease in surface charge density of bovine erythrocytes.
abstract: Decrease in electrophoretic mobility of erythrocytes, increase in Km of erythrocyte membrane acetylcholinesterase and decrease in the binding constant of 8-anilino-1-naphthalene sulfonate to erythrocyte membranes demonstrate a decrease in surface charge density of bovine erythrocytes during in vivo aging. This phenomenon seems to be species-specific; it may be due to a diminution of the sialic acid content but may also be contributed by conformational changes of membrane proteins.
mesh_terms: D000110:Acetylcholinesterase / Q000097:blood; D000817:Anilino Naphthalenesulfonates / Q000097:blood; D000818:Animals; D002417:Cattle; D004563:Electrochemistry; D004586:Electrophoresis; D004905:Erythrocyte Aging; D004910:Erythrocyte Membrane / Q000502:physiology*; D008565:Membrane Proteins / Q000097:blood; D011487:Protein Conformation; D012794:Sialic Acids / Q000097:blood; D013499:Surface Properties
chemical_list: D000817:Anilino Naphthalenesulfonates; D008565:Membrane Proteins; D012794:Sialic Acids; C027132:1-anilino-8-naphthalenesulfonate; D000110:Acetylcholinesterase