title: Hypoprothrombinemia associated with cefoperazone treatment.
abstract: A patient with acute renal failure and gram-negative septicemia developed hypoprothrombinemia during treatment with cefoperazone. The coagulation defect was corrected by vitamin K administration. A multifactorial pathogenetic mechanism of vitamin K deficiency that developed during treatment with parenteral antibiotics is presented.
mesh_terms: D002438:Cefoperazone / Q000009:adverse effects*; D006801:Humans; D007020:Hypoprothrombinemias / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D018805:Sepsis / Q000188:drug therapy; D014812:Vitamin K / Q000627:therapeutic use; D014813:Vitamin K Deficiency / Q000139:chemically induced
chemical_list: D014812:Vitamin K; D002438:Cefoperazone