[Quaternary salts of aminoethyl-p-aminobenzoates and aminoethyl-p-aminobenzamides. Synthesis and pharmacologic activity].
A series of quaternary salts of aminoethyl-p-aminobenzoates and aminoethyl-p-aminobenzamides was synthesized starting from 4-hydroxy-3-carbomethoxy benzoic acid. Pharmacological tests of these compounds show significant spasmolytic activity: in a few cases this was also selective, but at the same time bioavailability was low.
D062365:Aminobenzoates / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001549:Benzamides / Q000138:chemical synthesis* / Q000494:pharmacology; D005750:Gastric Juice / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000187:drug effects; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D010276:Parasympatholytics / Q000138:chemical synthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D062365:Aminobenzoates; D001549:Benzamides; D010276:Parasympatholytics
Sali quaternari di aminoetil-p-aminobenzoati e aminoetil-p-aminobenzamidi. Sintesi e attività farmacologica.