[Low-density lipoprotein cholesterol levels in hypercholesterolemic rabbits with or without carbon monoxide poisoning].
Low-density lipoproteins isolated by a selective precipitation procedure have been investigated in cholesterol-fed rabbits exposed or not to carbon monoxide. The main findings are a higher increase of their cholesterol content and cholesterol to phospholipid molar ratio without a modification in lecithin-cholesterol-acyltransferase activity in intoxicated animals. Thus, the aggravating effect of carbon monoxide exposure on the atherogenic properties of these lipoproteins could accelerate the development of atherosclerosis in cholesterol-fed rabbits.
D000818:Animals; D002249:Carbon Monoxide Poisoning / Q000097:blood* / Q000150:complications; D002784:Cholesterol / Q000097:blood*; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D006937:Hypercholesterolemia / Q000097:blood* / Q000150:complications; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood*; D008297:Male; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000378:metabolism; D010743:Phospholipids / Q000097:blood; D011817:Rabbits
D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D010743:Phospholipids; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase
Teneur en cholestérol des lipoprotéines légères chez le lapin hypercholestérolémique intoxiqué ou non par l'oxyde de carbone.