title: [Treatment of paranoid schizophrenia taking circadian biological rhythms into account].
abstract: Patients with paranoid schizophrenia display fully or partially unstable circadian rhythms. A comparison of three regimens of haloperidol administration shows that the generally accepted therapeutic mode with this drug (thrice daily) should be modified. A once a day administration scheme proves to be more effective. Patients with a partial instability of the circadian rhythms should be given the drug in the morning and those with complete instability in the evening since this regimen employing a lower daily dose of this neuroleptic and associated with fewer side effects ensures more pronounced and prolonged remissions occurring at a faster rate.
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure; D001831:Body Temperature; D002940:Circadian Rhythm; D003702:Delusions / Q000188:drug therapy; D005260:Female; D006212:Hallucinations / Q000188:drug therapy; D006220:Haloperidol / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D011674:Pulse; D012563:Schizophrenia, Paranoid / Q000188:drug therapy* / Q000503:physiopathology; D013577:Syndrome
chemical_list: D006220:Haloperidol
vernacular_title: Lechenie bol'nykh paranoidnoĭ shizofrenieĭ s uchetom sutochnykh biologicheskikh ritmov.