[Pharmacokinetic substantiation of the preoperative administration of kanamycin and cefazolin to patients with acute ischemia of the small intestine].
Kanamycin and cephazolin when injected intramuscularly 1 hour before the operation to patients with acute intestinal obstruction, strangulated hernia and acute occlusions of the mesenterial vessels in the dose of 1,0 mg were shown to easily penetrate into the abdominal organ tissues. Maximum concentrations of kanamycin in the peripheral blood were found during 1-2 h after an intramuscular injection, those of cephazolin--during the first hour. The effect of sephazolin in the prevention of pyoseptic complications was more pronounced than that of kanamycin.
D000208:Acute Disease; D000368:Aged; D001682:Biological Availability; D002437:Cefazolin / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007421:Intestine, Small / Q000098:blood supply*; D007511:Ischemia / Q000209:etiology / Q000601:surgery*; D007612:Kanamycin / Q000378:metabolism* / Q000627:therapeutic use; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011292:Premedication; D011300:Preoperative Care
D007612:Kanamycin; D002437:Cefazolin
Farmakokineticheskoe obosnovanie predoperatsionnogo vvedeniia kanamitsina i tsefazolina bol'nym s ostroĭ ishemieĭ tonkoĭ kishki.