Comparison of the analgesic effect of ten nonsteroidal anti-inflammatory drugs.
The analgesic effect of 10 anti-inflammatory drugs was compared using a single-blind method in 90 patients with rheumatoid arthritis. Each patient received two different drugs, for three days each and each drug was evaluated in 18 patients. After the trial, the patients considered which of the drugs they preferred. The greatest relief from pain was achieved by diclofenac, indomethacin, naproxen and tolfenamic acid, each of these being preferred by the majority of patients and being significantly (p less than 0.01) better than the least effective drugs ketoprofen and proquazone. Acetylsalicylic acid, azapropazone, carprofen and ibuprofen were considered intermediate in efficacy.
D000328:Adult; D000368:Aged; D000700:Analgesics; D000893:Anti-Inflammatory Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001032:Apazone / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001241:Aspirin / Q000627:therapeutic use; D002227:Carbazoles / Q000627:therapeutic use; D004008:Diclofenac / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use; D007213:Indomethacin / Q000627:therapeutic use; D007660:Ketoprofen / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000627:therapeutic use; D011799:Quinazolines / Q000627:therapeutic use; D062367:ortho-Aminobenzoates / Q000627:therapeutic use
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D002227:Carbazoles; D011799:Quinazolines; D062367:ortho-Aminobenzoates; D004008:Diclofenac; C009500:tolfenamic acid; C011385:proquazone; D009288:Naproxen; D007660:Ketoprofen; C007005:carprofen; D001032:Apazone; D001241:Aspirin; D007052:Ibuprofen; D007213:Indomethacin