New antibiotic U-64846: fermentation, isolation and characterization.
Antibiotic U-64846 is a new entity with the molecular formula C18H35C1N4O9 (MW 486). It is a very water soluble, reddish solid which decomposes above 300 degrees C and which is air-sensitive. The antibiotic is produced by Streptomyces braegensis and it inhibits a variety of Gram-positive bacteria. Acidic hydrolysis gave 3,7-diaminoheptanoic acid. The antibiotic gives 1H NMR, 13C NMR, IR and UV spectra which indicate it is not closely related to known antibiotic families.
D000588:Amines; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005285:Fermentation; D008401:Gas Chromatography-Mass Spectrometry; D006538:Heptanoic Acids; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D013302:Streptomyces / Q000378:metabolism*
D000588:Amines; D000900:Anti-Bacterial Agents; D006538:Heptanoic Acids; C040927:U 64846