title: Thiazides XI: partitioning of chlorothiazide in red blood cells after oral administration.
abstract: Uptake of chlorothiazide by red blood cells after oral drug administration was investigated. Chlorothiazide was administered to normal healthy volunteers as a solution or a tablet. Frequent blood samples were collected and analysed by a specific HPLC method. The results indicate that there is a significant uptake of chlorothiazide by red blood cells, resulting in a higher blood AUC compared to plasma AUC.
mesh_terms: D000284:Administration, Oral; D002740:Chlorothiazide / Q000008:administration & dosage / Q000097:blood*; D002851:Chromatography, High Pressure Liquid; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans
chemical_list: D002740:Chlorothiazide