Heart failure associated with high plasma 10-hydroxynortriptyline levels.
The authors describe a patient who developed congestive heart failure and had a high plasma concentration of 10-hydroxynortriptyline. They discuss the need for further research to define the contribution of antidepressants' active metabolites to toxic and therapeutic effects.
D000368:Aged; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy; D006333:Heart Failure / Q000097:blood / Q000139:chemically induced* / Q000378:metabolism; D006801:Humans; D006900:Hydroxylation; D008297:Male; D009661:Nortriptyline / Q000009:adverse effects* / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use
C013567:10-hydroxynortriptyline; D009661:Nortriptyline