title: [Activity of enzymes with an antioxidant action in the myocardium and blood of the rat during cardiovascular insufficiency].
abstract: It is found that glutathione reductase and superoxidismutase activity decreases in postmitochondrial fraction of the myocardium tissue under cardiovascular insufficiency of the hemodynamic type. In erythrocytes the activity of lipoperoxide-detoxicating glutathione peroxidase--GSH-peroxidase II lowers and that of hydrogen peroxide-utilizing GSH-peroxidase I grows. Disturbances in the antioxidant enzymic systems are discussed for their role in development of cardiac insufficiency.
mesh_terms: D000818:Animals; D001017:Aortic Coarctation / Q000150:complications; D004912:Erythrocytes / Q000201:enzymology*; D005979:Glutathione Peroxidase / Q000378:metabolism*; D005980:Glutathione Reductase / Q000378:metabolism*; D006333:Heart Failure / Q000188:drug therapy / Q000201:enzymology* / Q000209:etiology; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism*; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D014810:Vitamin E; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase
vernacular_title: Aktivnost' fermentov antioksidantnogo deĭstviia v miokarde i krovi krys pri serdechno-sosudistoĭ nedostatochnosti.