[Behavior and biological action of 239Pu administered intramuscularly during complexon therapy].
With intramuscular injection of 239Pu nitrate the radionuclide content of the rat skeleton was higher, and at the site of injection, lower, than with injection of a polymer plutonium. The animals developed osteosarcomas (nitrate greater than polymer), and at the site of trauma, fibrosarcomas (nitrate less than polymer). After a complexon therapy the dose accretion in the skeleton and liver diminished, the life span increased, and the incidence of sarcomas decreased.
D000042:Absorption; D000818:Animals; D001842:Bone and Bones / Q000378:metabolism / Q000528:radiation effects; D002614:Chelating Agents / Q000008:administration & dosage*; D005260:Female; D007273:Injections, Intramuscular; D008297:Male; D009132:Muscles / Q000378:metabolism / Q000528:radiation effects; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000401:mortality; D011005:Plutonium / Q000008:administration & dosage* / Q000378:metabolism; D051381:Rats; D013997:Time Factors
D002614:Chelating Agents; D011005:Plutonium
Povedenie i biologicheskoe deĭstvie 239Pu pri vnutrimyshechnom vvedenii v usloviiakh kompleksonoterapii.