Heat-enhanced reactivation of UV-irradiated adenovirus 2 is not associated with enhanced mutagenesis in HeLa cells.
The reversion frequency of an adenovirus 2 temperature-sensitive growth mutant irradiated with different doses of UV light was determined after infection of control, UV-irradiated and heat-shocked HeLa cells. No enhancement of mutagenesis by treatment of the cells was observed. Heat-enhanced viral reactivation does not therefore display a significant error-prone component.
D000260:Adenoviruses, Human / Q000235:genetics* / Q000528:radiation effects; D004260:DNA Repair; D004279:DNA, Viral / Q000235:genetics; D006367:HeLa Cells; D006358:Hot Temperature; D006801:Humans; D009154:Mutation
D004279:DNA, Viral