Effect of naloxone on the loss of consciousness induced by i.v. anaesthetic agents in man.
The effect of a specific opioid antagonist, naloxone, was studied in two comparable groups of patients who received i.v. the dose of an anaesthetic agent required to produce loss of consciousness in 50% of subjects. The first group received naloxone 0.006 mg kg-1 5 min before induction of anaesthesia; the second group received a similar volume of saline solution. Thiopentone, Althesin, diazepam, ketamine and propanidid were studied. The differences in percentage of unconscious patients between the naloxone-treated group and the control group were statistically significant for diazepam, ketamine and propanidid. Naloxone did not modify the induction of anaesthesia with thiopentone or Althesin.
D000328:Adult; D000530:Alfaxalone Alfadolone Mixture / Q000037:antagonists & inhibitors; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000037:antagonists & inhibitors*; D003243:Consciousness / Q000187:drug effects*; D003975:Diazepam / Q000037:antagonists & inhibitors; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007649:Ketamine / Q000037:antagonists & inhibitors; D008297:Male; D008875:Middle Aged; D009270:Naloxone / Q000494:pharmacology*; D011410:Propanidid / Q000037:antagonists & inhibitors; D013874:Thiopental / Q000037:antagonists & inhibitors
D000777:Anesthetics; D009270:Naloxone; D007649:Ketamine; D000530:Alfaxalone Alfadolone Mixture; D011410:Propanidid; D013874:Thiopental; D003975:Diazepam