title: Phase II enzyme induction reduces body burden of heptachlor in rats.
abstract: Contrary to expectations hexadecane had no significant effect on the body clearance of heptachlor in rats. However, phase II enzyme induction altered the kinetics of heptachlor dramatically, reducing its half-life by about 3-fold. The reduction of half-life was reflected in correspondingly lowered adipose tissue and blood levels.
mesh_terms: D000473:Alkanes / Q000494:pharmacology; D000818:Animals; D001646:Bile / Q000378:metabolism; D001822:Body Burden; D004790:Enzyme Induction; D005243:Feces / Q000032:analysis; D006207:Half-Life; D006533:Heptachlor / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000473:Alkanes; D006533:Heptachlor; C007932:n-hexadecane