Ciliated smooth muscle cells in aortic atherosclerotic lesions of rabbit.
Single rudimentary cilia were observed by electron microscopy in smooth muscle cells (SMCs) of aortic fatty streaks in hypercholesterolemic rabbits, but not in aortae of controls. Similar cilia are known to occur in several tissues and various species, but it is believed that they have not so far been identified in the SMCs of atherosclerotic lesions. These cilia differ structurally from the classical type characterising ciliated epithelium. It is currently thought that a sudden transformation from mitotic replicative to nonmitotic structuring tissue may be correlated with the disappearance of centrioles and formation of cilia. The possible implications of the above concept in the overall process of atherosclerosis in the context of our present-day knowledge is briefly discussed.
D000818:Animals; D001011:Aorta / Q000648:ultrastructure*; D001161:Arteriosclerosis / Q000473:pathology*; D002502:Centrioles / Q000648:ultrastructure; D002923:Cilia / Q000648:ultrastructure; D009131:Muscle, Smooth, Vascular / Q000648:ultrastructure*; D011817:Rabbits; D051381:Rats