Destructive spondylarthropathy in hemodialyzed patients. A new syndrome.
Spinal radiologic lesions suggestive of destructive spondylarthropathy were found in 10 patients on long-term hemodialysis. These lesions were characterized by severe narrowing of the intervertebral disc, associated with erosions and geodes of the adjacent vertebral plates without osteophytosis. In 9 of the 10 patients the lesions were located in the cervical spine, and in 1 patient, in the lumbar spine. Microbial spondylitis, degenerative disc disease, and destructive spondylarthropathy of calcium pyrophosphate dihydrate deposition disease were each, in turn, ruled out. The finding of apatite crystals by transmission electron microscopy in 1 disc specimen suggests that these crystals may be associated with destructive vertebral disc lesions in dialysis patients.
D000368:Aged; D002114:Calcinosis / Q000209:etiology / Q000378:metabolism; D005260:Female; D006801:Humans; D007403:Intervertebral Disc / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D011859:Radiography; D006435:Renal Dialysis / Q000009:adverse effects*; D013122:Spinal Diseases / Q000000981:diagnostic imaging / Q000209:etiology*; D013167:Spondylitis, Ankylosing / Q000000981:diagnostic imaging / Q000209:etiology*