Platelet-derived growth factor (PDGF) induces intranuclear protein accumulation in 3T3 fibroblasts.
Quiescent 3T3 fibroblasts were grown for a short time in the presence of [3H]amino acids then treated with PDGF, and the nucleo-cytoplasmic distribution of the 3H-labelled proteins was analysed by autoradiography. There was no difference in the total amount of 3H-labelled proteins in PDGF-treated and untreated cells but PDGF induced a significant increase in intranuclear protein accumulation.
D000818:Animals; D001345:Autoradiography; D002455:Cell Division; D002460:Cell Line; D002467:Cell Nucleus / Q000187:drug effects / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D005347:Fibroblasts; D051379:Mice; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism*
D010982:Platelet-Derived Growth Factor; D011506:Proteins; D004247:DNA