Control of the Zollinger-Ellison syndrome by excision of primary and metastatic tumor.
In a patient with Zollinger-Ellison syndrome, control of the peptic ulcer diathesis was attempted by excision of a small duodenal gastrinoma and removal of three lymph nodes containing metastases. The patient has been asymptomatic for 2.5 years with basal achlorhydria, a normal serum gastrin level and a negative gastrin response to secretin. Our experience with this patient emphasizes the fact that the presence of metastatic disease does not preclude the possibility of long-term control of hypergastrinemia by resection of the tumor. Attempts to cure the Zollinger-Ellison syndrome by tumor resection alone, however, should only be made in patients whose hypersecretion is adequately controlled by antisecretory drugs.
D000863:Antacids / Q000627:therapeutic use; D005260:Female; D005755:Gastrins / Q000097:blood; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis / Q000601:surgery; D015043:Zollinger-Ellison Syndrome / Q000188:drug therapy / Q000601:surgery*
D000863:Antacids; D005755:Gastrins