Effect of age on epinephrine-induced arrhythmias during halothane anaesthesia in pigs.
The effect of age on the arrhythmogenicity of epinephrine during halothane anaesthesia was studied in pigs of two different age groups. At a stable alveolar concentration of 0.84 volumes per cent halothane, ventricular arrhythmias could not be elicited in one- to three-day-old pigs by a 100 micrograms X kg-1 infusion of epinephrine. PVCs were produced in 50- to 55-day-old pigs at a mean epinephrine dose of 9.55 micrograms X kg-1. Heart rate, systolic blood pressure, and rate-pressure product were significantly higher before and during the epinephrine infusion in the 50- to 55-day-old pigs. It is concluded that there is an age dependent effect upon epinephrine induced arrhythmias during halothane anaesthesia in pigs.
D000375:Aging; D000769:Anesthesia, Inhalation; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D004837:Epinephrine / Q000008:administration & dosage / Q000633:toxicity*; D006221:Halothane; D006321:Heart / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects; D013552:Swine
D006221:Halothane; D004837:Epinephrine