[Interaction of solvent effects on the plasma membrane].
The combined effect of trichloroethylene and butanol on the behaviour of human erythrocytes during haemolysis in hypotensive milieu was investigated in comparison to the individual effects of solvents. In these cases, among others, appeared statistically significant quantitative changes of the maximum of stability. In a common influence of trichloroethylene and butanol and additional stabilisation of the membrane may be the result, which is traced back to various places of effect of the solvents. When 150 mmol/l butanol are used the haemolysis is suppressed by trichloroethylene in its concentration region of 8-10 mmol/l. This effect can be explained by additional inclusion of trichloroethylene in butanol-free lipid classes. When 200 mmol/l butanol are given the haemolysis much increases already at an application of 4 mmol/l trichloroethylene. Here trichloroethylene cannot infiltrate into other still butanol-free lipid classes, in order to evoke an additional stabilisation. On the contrary, in cooperation the decomposition of the crystal structure of the lipids (emulsification) and thus the haemolysis develops. These results refer to the fact that combined effects of solvents are not always to be valuated additively.
D000440:Butanols / Q000494:pharmacology*; D004347:Drug Interactions; D004910:Erythrocyte Membrane / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D012997:Solvents / Q000494:pharmacology*; D014241:Trichloroethylene / Q000494:pharmacology*
D000440:Butanols; D012997:Solvents; D014241:Trichloroethylene
Interaktion von Lösemittelwirkungen auf die Plasmamembran.