Effect of a lymphocyte-derived pro-inflammatory factor on carrageenan pleurisy in the rat.
An intravenous injection of a lymphocyte pro-inflammatory factor (LpIF), obtained from rat spleen, restored diminished fluid and cellular responses in carrageenan pleurisy in leucopenic animals. A similar filtrate of bone marrow cells had no restorative properties. Previous results from elsewhere indicated a single pro-inflammatory activity on the fluid component of inflammation. We propose that LpIF has a more significant effect by influencing both components of inflammation and suggest that the discrepancy may be due to the different models used.
D000818:Animals; D002351:Carrageenan; D007249:Inflammation / Q000276:immunology / Q000473:pathology; D007970:Leukopenia / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008222:Lymphokines / Q000502:physiology*; D008297:Male; D010998:Pleurisy / Q000276:immunology* / Q000473:pathology; D051381:Rats
D008222:Lymphokines; D002351:Carrageenan