Mortality experience of employees with occupational exposure to DBCP.
Concern about the carcinogenic potential of 1,2-dibromo-3-chloropropane(DBCP) has arisen recently, focusing on six organ sites: stomach, liver, kidney, lung, testes, and skin. To examine the mortality experience of persons potentially exposed, a cohort of 550 employees involved in production and formulation from 1957 to 1976 was defined. A total of 35 deaths was observed through 1979 (39.2 expected). No statistically significant excess was observed for any cause of death. No cancer deaths were noted for five of the hypothesized sites. For the lung cancer category, five deaths were observed (2.7 expected, P greater than .135), two of which occurred in a subgroup directly exposed for at least 1 yr (0.5 expected, P greater than .077). Aside from arsenicals exposure, potential confounding resulting from smoking or multiple chemical exposures could not be evaluated.
D000969:Antinematodal Agents / Q000009:adverse effects*; D002622:Chemistry, Agricultural; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000139:chemically induced / Q000401:mortality; D008113:Liver Neoplasms / Q000139:chemically induced / Q000401:mortality; D008175:Lung Neoplasms / Q000139:chemically induced / Q000453:epidemiology; D008297:Male; D009369:Neoplasms / Q000139:chemically induced* / Q000401:mortality; D009784:Occupational Diseases / Q000139:chemically induced* / Q000401:mortality; D012878:Skin Neoplasms / Q000139:chemically induced / Q000401:mortality; D013274:Stomach Neoplasms / Q000139:chemically induced / Q000401:mortality; D013736:Testicular Neoplasms / Q000139:chemically induced / Q000401:mortality; D014481:United States; D014484:United States Environmental Protection Agency
D000969:Antinematodal Agents