Polymerization of individual species of tree pollen allergens.
This report describes the preparation of individual tree pollen allergen polymers in contrast to our previous description of the polymerization of a mixture of tree pollens.. These individual polymers may be used for immunotherapy as indicated by the IgE-mediated reactivity of each patient. A modified chromatographic fractionation process was used which results in tree polymers with skin reactivity 1,000- to 10,000-fold less from monomers and with a defined lower molecular weight limit. The modified preparative methodology results in polymer preparations as safe but with greater ease of production than polymers prepared with previous methodologies.
D000485:Allergens / Q000008:administration & dosage; D002850:Chromatography, Gel; D006801:Humans; D007428:Intradermal Tests; D046911:Macromolecular Substances; D008970:Molecular Weight; D011058:Pollen / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis / Q000628:therapy; D014197:Trees
D000485:Allergens; D046911:Macromolecular Substances