Teratogenicity of TCDD and the congener 3,3',4,4'-tetrachloroazoxybenzene in sensitive and nonsensitive mouse strains after reciprocal blastocyst transfer.
The teratogenic sensitivity to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) and its congeners is straindependent in the mouse. Reciprocal blastocyst transfer was performed between sensitive (NMRI) and nonsensitive (DBA) strains to show if there is a direct effect on embryonic tissues or if damage is secondary to maternal effects. Treatment with TCDD (30 micrograms/kg body weight) and 3,3',4,4'-tetrachloroazoxy-benzene (TCAOB)(8 mg/kg) on day 12 caused cleft palate in 75-100% of all NMRI fetuses, irrespective of whether they had remained in their own (NMRI) dams or as aliens in DBA dams. Only 1 out of 25 alien NMRI fetuses in DBA dams did not develop cleft palate. Under the same conditions, none of the 24 DBA fetuses in NMRI dams had cleft palate, although 89% of their NMRI littermates were affected. Also, no DBA fetuses having developed in their own dams had cleft palate.
D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D001755:Blastocyst; D002972:Cleft Palate / Q000139:chemically induced; D004147:Dioxins / Q000633:toxicity*; D004624:Embryo Transfer; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D051379:Mice; D008811:Mice, Inbred DBA; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D011247:Pregnancy; D013045:Species Specificity; D013723:Teratogens
D001391:Azo Compounds; D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D013723:Teratogens; C013280:3,4,3',4'-tetrachloroazoxybenzene