Alteration of drug-protein binding in renal disease.
The protein binding of acidic drugs but not basic drugs is decreased in serum from patients with poor renal function. This decreased binding is due to the retention of compounds that displace drugs from their binding sites on albumin. Phenytoin and valproic acid are the 2 drugs that require a change in the values for therapeutic levels to allow for this decreased binding.
D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism*; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism; D014511:Uremia / Q000378:metabolism
D004364:Pharmaceutical Preparations; D012709:Serum Albumin