title: Splenic siderosis and parenteral iron dextran in maintenance haemodialysis patients.
abstract: The histological features of 40 spleens surgically removed from maintenance haemodialysis patients are reported. Twenty-four of the 40 (60%) showed massive iron loading and a significant direct correlation was found between iron loading and the amount of intravenous iron dextran administered. Since parenteral iron dextran appears to be a major factor in causing iron overload in haemodialysis patients its use as a method of iron replacement in these patients would appear inappropriate.
mesh_terms: D001803:Blood Transfusion; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007501:Iron / Q000032:analysis; D007505:Iron-Dextran Complex / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D006435:Renal Dialysis; D012806:Siderosis / Q000209:etiology* / Q000378:metabolism; D013154:Spleen / Q000032:analysis; D013158:Splenic Diseases / Q000139:chemically induced* / Q000378:metabolism
chemical_list: D007505:Iron-Dextran Complex; D007501:Iron