Effect of sodium fluoride on hepatic microsomal mixed-function oxidase system in newborn and adult male rats.
Administration i.p. of sodium fluoride at 2.5 or 5.0 mg/kg induced the mixed-function oxidase system in both newborn and adult rats; at 10.0 mg/kg there was induction in newborn rats and inhibition in adult rats, and at 20.0 mg/kg, there was inhibition in both newborn and adults.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D004790:Enzyme Induction / Q000187:drug effects; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D051381:Rats; D012969:Sodium Fluoride / Q000494:pharmacology*
D012969:Sodium Fluoride; D006899:Mixed Function Oxygenases