Evidence for cholecystokinin-like immunoreactive neurons in the rat medulla oblongata which project to the spinal cord.
The distribution of cholecystokinin-like immunoreactive (CCK-LI) neurons has been mapped in the rat medulla after local and intracerebroventricular colchicine injections. CCK-positive neurons were found in the nucleus raphe magnus, nucleus raphe pallidus, nucleus raphe obscurus, nucleus paragigantocellularis pars alpha, and a population of ventral medullary neurons. Combined retrograde tracing with the fluorescent dye True Blue and indirect immunofluorescence for visualizing CCK neurons suggested that there was a CCK-LI system originating in the medulla and projecting to the spinal cord. Additional double labelling experiments established that some of these CCK-LI containing neurons also contain 5-HT.
D000818:Animals; D001931:Brain Mapping; D002766:Cholecystokinin / Q000378:metabolism*; D008297:Male; D008526:Medulla Oblongata / Q000033:anatomy & histology* / Q000378:metabolism; D009046:Motor Neurons / Q000378:metabolism; D011903:Raphe Nuclei / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D013116:Spinal Cord / Q000033:anatomy & histology* / Q000378:metabolism
D012701:Serotonin; D002766:Cholecystokinin