[Effect of high-density lipoproteins on cholesterol biosynthesis in rat liver].
Under the conditions of long-term intravenous perfusion to recipient rats of a solution of rat high density lipoproteins at a concentration exceeding the physiological one and in the absence of stressor components, the animals' liver tissue manifested a significant decrease in free cholesterol. Since the rate of the label incorporation in liver cholesterol increased concurrently, it is suggested that a considerable rise in the content of high density lipoproteins in the blood of rats under the physiological conditions may lead to a fall in liver cholesterol because of which the developing hypocholesterolemia gives rise to the activation of the synthesis of this sterol.
D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis* / Q000097:blood; D007263:Infusions, Parenteral; D008075:Lipoproteins, HDL / Q000008:administration & dosage*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D008075:Lipoproteins, HDL; D002784:Cholesterol
Deĭstvie lipoproteidov vysokoĭ plotnosti na biosintez kholesterina v pecheni krys.