title: Necrotizing fasciitis of vulvar origin in diabetic patients.
abstract: Necrotizing fasciitis is a rare, rapidly progressive, and often fatal infection of the superficial fascia and subcutaneous tissues. The integrity of the deep muscle fascia is usually not breeched, thus limiting the depth of involvement. Centrifugal spread within the planes of the superficial fascia and subcutaneous tissues is characteristic. Patients with diabetes mellitus constitute the group most vulnerable to necrotizing fasciitis, and a vulvar or perineal origin is associated with particularly high mortality. The authors report four such patients. Other apparent predisposing factors are advancing age, peripheral vascular disease, chronic debilitating illness, malnutrition, and possibly other states predisposing patients to immunodeficiency. None of these factors is an absolute prerequisite to the development of necrotizing fasciitis.
mesh_terms: D000328:Adult; D048909:Diabetes Complications; D005208:Fasciitis / Q000209:etiology* / Q000401:mortality / Q000601:surgery; D005260:Female; D006801:Humans; D008875:Middle Aged; D009336:Necrosis; D013290:Streptococcal Infections / Q000209:etiology / Q000401:mortality / Q000601:surgery; D014845:Vulvar Diseases / Q000209:etiology* / Q000401:mortality / Q000601:surgery