Fast-cycling bipolar disorder induced by withdrawal from long-term treatment with a tricyclic antidepressant.
A unipolar depressed patient developed a fast-cycling bipolar disorder on abrupt discontinuation of long-term treatment with a tricyclic antidepressant. The case illustrates the potential for drug withdrawal to induce mood disturbance that is more severe than the original illness.
D001714:Bipolar Disorder / Q000139:chemically induced* / Q000523:psychology; D003866:Depressive Disorder / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000009:adverse effects*; D008875:Middle Aged; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
D007099:Imipramine