[Leukocyte count and granulocyte function of children under lithium carbonate therapy treated with cytostatic drugs. A pilot study].
The usefullness of lithium carbonate for attenuation of leukopenia due to chemotherapy was studied in a prospective randomized trial. Chemotherapy for solid tumors was applied in a paired manner 24 times without and 24 times with lithiumcarbonate. Simultaneously, nucleotid-dependent functions of granulocytes were examined. An attenuation of leukopenia by lithium was observed. Toxic side effects within the therapeutic range of the serum level (0.3-1.4 mol/l) were not detected. Lithium did not impair adherence, chemotaxis and degranulation of neutrophile granulocytes. The influences of lithium on stem-cell maturation and granulocyte function are discussed.
D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002448:Cell Adhesion / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D006098:Granulocytes / Q000187:drug effects*; D006801:Humans; D007958:Leukocyte Count; D007970:Leukopenia / Q000139:chemically induced / Q000188:drug therapy*; D008094:Lithium / Q000494:pharmacology / Q000627:therapeutic use*; D010865:Pilot Projects
D008094:Lithium
Leukozytenzahl und Granulozytenfunktion zytostatisch behandelter Kinder unter Lithiumcarbonat. Eine Pilotstudie.