title: Piroxicam-induced renal disease.
abstract: Two cases of nephrotoxicity associated with piroxicam therapy are reported. In the first case, severe reversible azotemia with hyperkalemia resolved after discontinuation of the medication. In the second case, biopsy-proved acute interstitial nephritis with immune complex glomerulonephritis and hepatitis improved after steroid therapy. The mechanism for such toxicity may be altered hemodynamics, cellular immunity, or humoral immunity related to prostaglandin inhibition.
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D005260:Female; D006333:Heart Failure / Q000188:drug therapy; D006801:Humans; D006947:Hyperkalemia / Q000139:chemically induced; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000139:chemically induced*; D009404:Nephrotic Syndrome / Q000139:chemically induced*; D010894:Piroxicam; D013843:Thiazines / Q000009:adverse effects*; D014511:Uremia / Q000139:chemically induced
chemical_list: D013843:Thiazines; D010894:Piroxicam