[Effect of pentoxyfylline and xanthinol nicotinate on the overall blood pressure and tonus of cerebral and peripheral vessels].
It has been demonstrated in cat experiments that pentoxyphylline (10 and 20 mg/kg intravenously, 1 mg/kg intraarterially) and xanthinole nicotinate (75 mg/kg intravenously) first produce dilatation on the part of the perfused vessels, with this dilatation progressing to the constriction in some of the experiments. As the dose of pentoxyphylline raised the arterial blood pressure, whereas after pentoxyphylline administration the phase alterations of AP were observed not infrequently: at first the pressure decreased and then rose as compared to the initial level.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D002536:Cerebral Arteries / Q000187:drug effects*; D006614:Hindlimb / Q000098:blood supply; D010431:Pentoxifylline / Q000494:pharmacology*; D013805:Theobromine / Q000031:analogs & derivatives*; D013806:Theophylline / Q000031:analogs & derivatives*; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects*; D014971:Xanthinol Niacinate / Q000494:pharmacology*
D014971:Xanthinol Niacinate; D013806:Theophylline; D013805:Theobromine; D010431:Pentoxifylline
Vliianie pentoksifillina i ksantinola nikotinata na obshchee arterial'noe davlenie, tonus mozgovykh i perifericheskikh sosudov.