Effects of high-dose fentanyl anaesthesia on the established metabolic and endocrine response to surgery.
The effect of the administration of fentanyl 50 micrograms/kg body weight on the established metabolic response to pelvic surgery was investigated. In comparison with a control group of patients in whom anaesthesia was supplemented with halothane, fentanyl was associated with a significant decrease in only blood lactate concentrations and heart rate. There were no significant differences in blood glucose, plasma non-esterified fatty acids, and plasma cortisol values between the two anaesthetic techniques. It is concluded that the administration of high-dose fentanyl has little effect on the established metabolic response to surgery, compared with the marked changes observed when the same dose is given before the onset of surgical stimulation.
D000328:Adult; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D005187:Fallopian Tubes / Q000601:surgery*; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage* / Q000494:pharmacology; D006221:Halothane; D006339:Heart Rate / Q000187:drug effects; D006400:Hematocrit; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007773:Lactates / Q000097:blood; D019344:Lactic Acid
D001786:Blood Glucose; D007773:Lactates; D019344:Lactic Acid; D005283:Fentanyl; D006221:Halothane; D006854:Hydrocortisone