A search for the mechanism underlying the altered MCV in thyroid dysfunction: a study of serum and red cell membrane lipids.
The mean red cell volume (MCV) is increased in hypo- and decreased in hyperthyroidism but the underlying cause(s) is unknown. In view of the well recognised alterations in serum lipids in thyroid dysfunction, we have examined the possibility that a corresponding alteration in the amount or distribution of lipids in the red cell membrane may account for the red cell volume changes. Our findings however do not support this hypothesis.
D000328:Adult; D000368:Aged; D002784:Cholesterol / Q000097:blood; D004909:Erythrocyte Indices; D004910:Erythrocyte Membrane / Q000032:analysis / Q000502:physiology; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood*; D007037:Hypothyroidism / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008563:Membrane Lipids / Q000097:blood*; D008875:Middle Aged; D010743:Phospholipids / Q000097:blood
D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008563:Membrane Lipids; D010743:Phospholipids; D002784:Cholesterol