Testicular atrophy of rats induced by di-2-ethylhexyl phthalate: effects of vitamin A and zinc concentrations in the testis, liver and serum.
Dietary administration of di-2-ethylhexyl phthalate (DEHP, 2% in diet) for 1 week to young male Wistar rats was found to cause testicular atrophy. Zinc (Zn) concentration in the testis and liver of DEHP-treated rats was lower than that in controls. Vitamin A concentration in serum and testis was increased in DEHP-treated rats. These results suggest that testicular atrophy induced by DEHP was not due to dietary or intrinsic vitamin A deficiency.
D000818:Animals; D001284:Atrophy; D004051:Diethylhexyl Phthalate / Q000633:toxicity*; D008099:Liver / Q000032:analysis; D008297:Male; D010795:Phthalic Acids / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000032:analysis / Q000187:drug effects* / Q000473:pathology; D014801:Vitamin A / Q000032:analysis* / Q000097:blood; D015032:Zinc / Q000032:analysis* / Q000097:blood
D010795:Phthalic Acids; D014801:Vitamin A; D004051:Diethylhexyl Phthalate; D015032:Zinc