Inhibition of nerve fiber regeneration in cultured sympathetic neurons by local, high potassium.
Distal regeneration of neurites from cultured sympathetic neurons of newborn rats was stunted by exposure to local, high K+ (20 mM), only when more proximal neurite regions and the cell bodies were exposed to a normal K+ concentration (5 mM). Neurites grew luxuriantly and extensively when exposure to high K+ was uniform over the entirety of the neurons. Thus, neurite growth can be strongly influenced by regional variations in K+ which are probably within the naturally occurring range, especially during development and regeneration.
D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D003864:Depression, Chemical; D008564:Membrane Potentials; D009416:Nerve Regeneration / Q000187:drug effects*; D011188:Potassium / Q000494:pharmacology* / Q000502:physiology; D051381:Rats; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000254:growth & development
D011188:Potassium