A second peak in uptake of gentamicin by rat kidney after cessation of treatment.
Gentamicin was administered s.c. to rats once daily for 7 days at 5 mg kg-1. At the end of this period renal concentrations of gentamicin declined from day 1 to day 5 postdosing, but showed a second peak on day 8, after which they declined again through days 16 and 22. This second peak coincided with a peak of mitotic activity in the kidney, suggesting that this organ, while recovering from gentamicin-induced damage, passes through a temporary phase during which it has increased affinity for gentamicin.
D000818:Animals; D005260:Female; D005839:Gentamicins / Q000378:metabolism* / Q000633:toxicity; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005839:Gentamicins