[Synthesis of 2-substituted alkanolphosphoric acid esters with lytic effects].
Lysolipid analogues were synthetized and tested for haemolytic activity. Initial substances were long-chain 2-methylalkanols, as well as 2-hexadecylpropane-1,3-diol. The latter compound was prepared starting with hexadecylmalonic acid diester. Among the compounds synthetized, there were also 1-acetoxy-2-hexadecylpropan-3-ol-phosphocholine and acidic-reacting lysolipid analogues.
D055598:Chemical Phenomena; D002621:Chemistry; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D008244:Lysophosphatidylcholines / Q000138:chemical synthesis* / Q000494:pharmacology; D008970:Molecular Weight
D008244:Lysophosphatidylcholines
Synthese von lysierend wirkenden 2-substituierten Alkanolphosphorsäureestern.