Platelet storage pool disease in hybrid rats. F1 fawn-hooded rats derived from crosses with their putative ancestors (Rattus norvegicus).
Fawn-hooded rats have a hemorrhagic disorder known as platelet storage pool deficiency. Parent stocks of Fawn-hooded, Long-Evans, and Wistar (DAB) rats and the progeny of their reciprocal crosses were studied for coat color and percentage 14C-serotonin uptake and secretion by blood platelets. Progeny of Fawn-hooded and Wistar reciprocal crosses were dark- or light-hooded, whereas all reciprocal crosses with the Long-Evans stock were dark-hooded. The light or fawn hood was significantly associated with the reduced serotonin uptake and secretion characteristic of storage pool efficiency.
D000818:Animals; D001791:Blood Platelet Disorders / Q000235:genetics* / Q000378:metabolism; D006824:Hybridization, Genetic; D051381:Rats / Q000235:genetics*; D011919:Rats, Inbred Strains / Q000235:genetics; D012701:Serotonin / Q000378:metabolism
D012701:Serotonin