Conversion of 3-nitropropanol (miserotoxin aglycone) to 3-nitropropionic acid in cattle and sheep.
The metabolism of intravenously administered 3-nitropropanol (miserotoxin aglycone) was examined in cattle and sheep using high-pressure liquid chromatography (HPLC) to determine nitrocompounds in plasma. 3-Nitropropanol (NPOH) showed a rapid rate of decay and simultaneously, 3-nitropropionic acid (NPA) was detected at comparable levels in plasma. In animals dosed with NPOH, the observed NPA decayed at a slower rate than NPOH. Nitrite levels in plasma were more closely related to NPA than to NPOH. Therefore, metabolism of NPOH is linked to NPA and this could provide a common basis for the toxicity of these compounds in cattle and sheep.
D000433:1-Propanol / Q000378:metabolism; D000818:Animals; D002417:Cattle; D002851:Chromatography, High Pressure Liquid; D005260:Female; D007263:Infusions, Parenteral; D008297:Male; D009573:Nitrites / Q000097:blood; D009574:Nitro Compounds; D020005:Propanols; D011422:Propionates / Q000097:blood*; D012756:Sheep
D009573:Nitrites; D009574:Nitro Compounds; D020005:Propanols; D011422:Propionates; C024522:3-nitro-1-propanol; D000433:1-Propanol; C015392:3-nitropropionic acid