[Genetic effect of 14C incorporated into the male germ cells of mice. Long-term and chronic 14C-glucose administration].
A study was made of the effect of 14C glucose after long-term (33 days) and chronic (6 and 12 months) per os administration to male mice (CBA X C57B1)F1. The average absorbed doses in gonads were 1.47 and 0.74 Gy after long-term administration and 0.066 and 0.013 Gy after chronic administration of 14C glucose. The tests used were: the frequencies of dominant lethal mutations (DLM), reciprocal translocations (RT), and abnormal sperm heads (ASH). The frequencies of DLM and RT were only shown to increase, with radiation dose, after long-term administration of 14C glucose. After chronic administration, of 14C glucose in the doses applied the effect was absent.
D000818:Animals; D002250:Carbon Radioisotopes / Q000378:metabolism*; D005260:Female; D005799:Genes, Dominant / Q000528:radiation effects; D005804:Genes, Lethal / Q000528:radiation effects; D005947:Glucose / Q000008:administration & dosage*; D008297:Male; D008540:Meiosis / Q000528:radiation effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009154:Mutation; D013094:Spermatozoa / Q000378:metabolism / Q000528:radiation effects*; D013997:Time Factors; D014178:Translocation, Genetic / Q000528:radiation effects
D002250:Carbon Radioisotopes; D005947:Glucose
Geneticheskiĭ éffekt inkorporirovannogo 14C v muzhskikh polovykh kletkakh mysheĭ. Dlitel'noe i khronicheskoe vvedenie 14C-gliukozy.