Toxicokinetics of [14C]hexafluoroacetone in the rat.
The disposition and metabolism of [14C]hexafluoroacetone (HFA) were studied in the rat as part of an investigation of the mechanism of HFA-induced testicular atrophy. After sc injection of 13 mg/kg [14C]HFA, radioactivity was eliminated in a biphasic manner from the blood; the half-life of the initial phase was 22.6 hr and that of the elimination phase 75.1 hr. Following injection of 130 mg/kg [14C]HFA, the elimination of radioactivity was initially zero order, but with time it became first order and biphasic with half-lives of the initial and terminal elimination phases being 23.0 and 59.9 hr, respectively. The primary route of elimination was via the urine and all of the [14C]HFA was excreted unmetabolized. [14C]HFA was uniformly distributed throughout the major organs of the body with the exception of the liver which contained disproportionately higher levels of [14C]HFA. The hepatic binding of [14C]HFA was noncovalent and capacity limited. Notably, the testes, the target organ of HFA-induced toxicity, did not exhibit any unusual accumulation or retention of [14C]HFA.
D000096:Acetone / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000652:urine; D000818:Animals; D005466:Fluorocarbons / Q000097:blood / Q000378:metabolism* / Q000652:urine; D006207:Half-Life; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D013737:Testis / Q000378:metabolism; D014018:Tissue Distribution; D006845:Hydrocarbons, Fluorinated
D000096:Acetone; D005466:Fluorocarbons; C017366:hexafluoroacetone; D006845:Hydrocarbons, Fluorinated