Effect of prazosin on blood pressure and plasma lipids in patients receiving a beta-blocker and diuretic regimen.
When prazosin was added to a beta-blocker/diuretic regimen, there was a further and statistically significant (p less than 0.05) reduction in blood pressure (12.7 percent supine diastolic pressure) but no significant change in heart rate. Mean high-density lipoprotein cholesterol increased by 10.8 percent (p less than 0.05) during prazosin treatment whereas very low-density lipoprotein and low-density lipoprotein cholesterol decreased. Together these changes contributed to a significant (p less than 0.05) increase in the ratio of high-density lipoprotein: low-density lipoprotein plus very low-density lipoprotein cholesterol of 13.3 percent. The reduction in total cholesterol was more marked in patients with elevated cholesterol levels (260 mg/100 ml or greater); in this group, total cholesterol and triglyceride levels were significantly reduced (p less than 0.05) during prazosin treatment.
D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D002752:Chlorthalidone / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D010096:Oxprenolol / Q000627:therapeutic use; D011224:Prazosin / Q000627:therapeutic use*; D011799:Quinazolines / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood
D008074:Lipoproteins; D011799:Quinazolines; D014280:Triglycerides; D010096:Oxprenolol; D002784:Cholesterol; D002752:Chlorthalidone; D011224:Prazosin