title: Electronic structures of cephalosporins and penicillins. 15. Inductive effect of the 3-position side chain in cephalosporins.
abstract: Induction appears to be the primary means by which the side chain at position 3 of the cephem nucleus influences the chemical reactivity of the beta-lactam ring. In vitro antibacterial activity data suggest that when the cephalosporin is in the active site of the target bacterial enzymes, the presence of a leaving group in the side chain can promote inhibition.
mesh_terms: D002511:Cephalosporins / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D006090:Gram-Negative Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000633:toxicity*; D013329:Structure-Activity Relationship
chemical_list: D002511:Cephalosporins; D010406:Penicillins