Effect of novobiocin on mycoplasma virus L2 replication.
L2 is a temperate mycoplasma virus containing 11.8 kilobase pairs of negatively superhelical double-stranded DNA. We observed L2 DNA with less superhelicity in novobiocin-treated cells than that in untreated cells. However, although no change in viral DNA superhelicity could be found in novobiocin-treated novobiocin-resistant cells, L2 production decreased in these novobiocin-treated cells.
D000128:Acholeplasma laidlawii; D001435:Bacteriophages / Q000187:drug effects*; D009675:Novobiocin / Q000494:pharmacology*; D014779:Virus Replication / Q000187:drug effects*
D009675:Novobiocin