Murine regional brain monoamine oxidase activity: time- and age-dependent response to inhibitors.
The inhibitory effect of procaine hydrochloride and Gerovital-H3 on monoamine oxidase (MAO) activity in the rat brain was studied at six time points during the 24-hour cycle. It was found that the percent inhibition is time dependent. Both drugs showed maximum inhibition when the MAO activity was at the lowest values during the 24-hour period. In addition to time dependence, these drugs are also age dependent because the MAO activity varies with age.
D000375:Aging; D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000201:enzymology*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D011343:Procaine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014018:Tissue Distribution
D008996:Monoamine Oxidase Inhibitors; C004936:Gerovital H3; D011343:Procaine; D008995:Monoamine Oxidase