Lens calcium and selenite-induced cataract.
Subcutaneous injection of sodium selenite into young rats produces a nuclear cataract within 72 hours. A three-fold elevation in lens calcium and a two-fold increase in lens inorganic phosphate have been found to precede opacification. Scanning electron micrographs suggested weakened cell-to-cell adhesion in the cataractous nuclear zone.
D000818:Animals; D002118:Calcium / Q000378:metabolism* / Q000502:physiology; D002386:Cataract / Q000139:chemically induced* / Q000378:metabolism / Q000473:pathology; D005260:Female; D007908:Lens, Crystalline / Q000378:metabolism; D008297:Male; D008855:Microscopy, Electron, Scanning; D010710:Phosphates / Q000378:metabolism; D051381:Rats; D020887:Selenious Acid; D012643:Selenium / Q000633:toxicity*
D010710:Phosphates; D020887:Selenious Acid; D012643:Selenium; D002118:Calcium