title: Prevalence of achlorhydria in a normal population and its relation to serum gastrin.
abstract: In a middle-aged group of normal subjects achlorhydria after maximal stimulation with pentagastrin was found in 12 out of 366 males (3%) and 2 out of 198 females (1%); 13 of these 14 (93%) had an elevated serum gastrin, of which nine were more than two times normal. In another 11 persons a moderately elevated serum gastrin - less than two times normal - was found in absence of achlorhydria. At least seven of them had hypochlorhydria. Of 540 persons with a normal serum gastrin one had achlorhydria. Determination of the serum gastrin appeared to be fairly reliable as a method of detecting achlorhydria.
mesh_terms: D000126:Achlorhydria / Q000097:blood*; D000328:Adult; D000423:Alcian Blue / Q000097:blood*; D005215:Fasting; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000032:analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007211:Indoles / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010418:Pentagastrin; D010619:Phenazines / Q000097:blood*; D010640:Phenothiazines / Q000097:blood*; D012118:Resorcinols / Q000097:blood*
chemical_list: D007211:Indoles; D010619:Phenazines; D010640:Phenothiazines; D012118:Resorcinols; C034790:astrin; D010418:Pentagastrin; D000423:Alcian Blue