title: Renal failure in Wegener's granulomatosis: recovering following dialysis and cyclophosphamide-prednisone therapy.
abstract: Two patients with Wegener's granulomatosis, crescentic glomerulonephritis, and severe renal failure are described. Both patients required hemodialysis for control of uremic symptoms. Cyclophosphamide-prednisone therapy successfully controlled the extra-renal manifestations of their disease and reversed the renal failure so that dialysis could be discontinued.
mesh_terms: D058186:Acute Kidney Injury / Q000150:complications / Q000473:pathology / Q000628:therapy*; D000368:Aged; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000473:pathology / Q000628:therapy; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007668:Kidney / Q000473:pathology; D008875:Middle Aged; D011239:Prednisolone / Q000008:administration & dosage*; D006435:Renal Dialysis
chemical_list: D003520:Cyclophosphamide; D011239:Prednisolone