title: Stability of cefsulodin in aqueous buffered solutions and some intravenous admixtures.
abstract: The stability of cefsulodin in aqueous solutions of various pH values, buffer concentrations, ionic strengths and intravenous admixtures were studied using a stability-indicating high-pressure liquid chromatography method. The pH range of optimum stability was determined to be 3.2-5.7. Cefsulodin was more stable on the acidic and less on the alkaline side as compared with most of the other cephalosporins such as cefoxitin (pH range of optimum stability approximately 4-7). In 5% dextrose and 0.9% sodium chloride injection, cefsulodin was stable (at least 90% potent) for about 1, 17 and at least 60 days at 24 degrees, 5 degrees and -10 degrees C, respectively.
mesh_terms: D002021:Buffers; D002441:Cefsulodin; D002511:Cephalosporins / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004355:Drug Stability; D004356:Drug Storage; D006863:Hydrogen-Ion Concentration; D007275:Injections, Intravenous; D009994:Osmolar Concentration; D012996:Solutions; D013696:Temperature; D013997:Time Factors
chemical_list: D002021:Buffers; D002511:Cephalosporins; D012996:Solutions; D002441:Cefsulodin