title: Simple synthesis of F-18-labeled 2-fluoro-2-deoxy-D-glucose: concise communication.
abstract: Fluorine-18 acetyl hypofluorite, produced by a gas/solid-phase reaction, was reacted with D-glucal in water, followed by treatment with HCl and serial passage through columns of charcoal, ion-retardation resin, and alumina. The product was an injectable solution of 2-[18F]fluoro-2-deoxy-D-glucose. The radiochemical purity was greater than 95% and the radiochemical yield was about 40%. The synthesis was completed in about 15 min. Acetyl hypofluorite was shown to be a stable, highly stereoselective fluorinating agent in aqueous systems over a wide pH range.
mesh_terms: D000085:Acetates; D002855:Chromatography, Thin Layer; D003837:Deoxy Sugars / Q000138:chemical synthesis*; D003847:Deoxyglucose / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D004952:Esters; D005461:Fluorine; D019788:Fluorodeoxyglucose F18; D007202:Indicators and Reagents; D007553:Isotope Labeling; D011854:Radiochemistry; D011868:Radioisotopes
chemical_list: D000085:Acetates; D003837:Deoxy Sugars; D004952:Esters; D007202:Indicators and Reagents; D011868:Radioisotopes; D019788:Fluorodeoxyglucose F18; D005461:Fluorine; C040801:acetyl hypofluorite; D003847:Deoxyglucose