Systemic suppression of contact hypersensitivity by ultraviolet b radiation or methoxsalen/ultraviolet a radiation in the guinea pig.
Treatment of strain 2 guinea pigs with ultraviolet b (uvb) (280-320 nm) radiation or methoxsalen, followed by ultraviolet a (uva) (320-400 nm) radiation, decreased the contact hypersensitivity (CHS) reaction to sensitizing agents applied subsequently to unirradiated sites. The decreased reactivity could be transferred to syngeneic animals and appeared to be caused by antigen-specific suppressor T lymphocytes. Ultraviolet b irradiation of sensitized animals did not affect elicitation of CHS in unirradiated skin.
D000818:Animals; D003877:Dermatitis, Contact / Q000276:immunology*; D004139:Dinitrofluorobenzene / Q000276:immunology; D005260:Female; D006168:Guinea Pigs; D007108:Immune Tolerance / Q000187:drug effects / Q000528:radiation effects; D008730:Methoxsalen / Q000494:pharmacology*; D010081:Oxazolone / Q000276:immunology; D014466:Ultraviolet Rays
D010081:Oxazolone; D004139:Dinitrofluorobenzene; D008730:Methoxsalen