[Changes in trace reactions of sensorimotor cortex and putamen neurons as affected by haloperidol].
Experiments on conscious rabbits were made to elaborate motor conditioned reflexes through pairing stimuli with electrocutaneous reinforcement applied every 30 s. Neuronal activity in the sensorimotor cortex and putamen was recorded during formation and reproduction of the conditioned reflexes before and after haloperidol injection (0.2 mg/kg i. v.). In the putamen, haloperidol increased the number of neurons exhibiting trace conditioned activity and made the intensity and duration of these processes rise. The changes seen in the sensorimotor cortex were opposite in nature. Inhibition of trace conditioned activity in the sensorimotor cortex depended mainly on the decreased amplitude of the reaction conditioned component. The role of the dopaminergic system in the interaction of the neostriatum and sensorimotor cortex and in formation and reproduction of trace conditioned activity of both the structures is discussed.
D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology*; D011699:Putamen / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits; D013003:Somatosensory Cortex / Q000187:drug effects / Q000502:physiology*
D006220:Haloperidol
Osobennosti izmeneniia sledovykh reaktsiĭ neĭronov sensomotornoĭ kory i skorlupy pri deĭstvii galoperidola.