Effects of p-aminohippurate and pyrazinoate on urate excretion in Cebus monkeys.
Changes in the fractional excretion of urate (FEurate) induced by various concentrations of p-aminohippurate (PAH) and pyrazinoate in plasma were evaluated in anesthetized Cebus monkeys using the standard clearance technique. PAH at concentrations between 2 and 40 micrograms/ml produced modest uricosuria (delta FEurate, ca 50%). At higher concentrations of PAH (up to 1200 micrograms/ml) the values of FEurate were not different from controls. Pyrazinoate at concentrations between 1 and 700 micrograms/ml reduced FEurate. The depressant effect of pyrazinoate was not influenced by the presence of PAH. These results are consistent with the idea that the secretory component for urate is distinct from that for PAH in this monkey.
D000618:Aminohippuric Acids / Q000494:pharmacology*; D000818:Animals; D002428:Cebus; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D011718:Pyrazinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D014527:Uric Acid / Q000378:metabolism / Q000652:urine*; D010130:p-Aminohippuric Acid / Q000494:pharmacology*
D000618:Aminohippuric Acids; D014527:Uric Acid; D011718:Pyrazinamide; C005296:pyrazinoic acid; D010130:p-Aminohippuric Acid