Dinemorphan N-demethylation by mouse liver microsomes.
Dinemorphan, an antitussive drug, is N-demethylated in vitro by mouse liver microsomes with biphasic kinetics showing two apparent Km and Vmax. Moreover, dinemorphan N-demethylation is inhibited by CO, SKF-525A, metyrapone and it is specifically catalyzed by a phenobarbital-inducible form of cytochrome P-450.
D000818:Animals; D000996:Antitussive Agents / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009019:Morphinans / Q000378:metabolism*; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology
D000996:Antitussive Agents; D009019:Morphinans; D008748:Methylcholanthrene; C012621:dimemorfan; D010089:Oxidoreductases, N-Demethylating; D010634:Phenobarbital