Enhancement of colonic cancer by indomethacin treatment in dimethylhydrazine pretreated rats.
Indomethacin treatment to rats bearing dimethylhydrazine-induced colonic cancer resulted in increased mortality (p less than 0.01) and a greater incidence of metastases compared to untreated animals with the same stage of disease. It is postulated that indomethacin might have a promotional effect on the spread of autochthonous experimental colon cancer.
D000818:Animals; D002273:Carcinogens; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000473:pathology; D004127:Dimethylhydrazines / Q000633:toxicity*; D004357:Drug Synergism; D005260:Female; D007213:Indomethacin / Q000633:toxicity*; D008763:Methylhydrazines / Q000633:toxicity*; D009362:Neoplasm Metastasis; D051381:Rats; D011916:Rats, Inbred F344
D002273:Carcinogens; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D007213:Indomethacin