[Functional state of cells and intracellular structures exposed to regeneration stimulators at early stages of the membranotropic effect of environmental chemicals].
The authors provide the biochemical, morphological and morphometry data on the functions of the cells (alveolar macrophages of the lungs) and intracellular structures (lysosomes, microsomes) of the liver and macrophages from rats exposed to a widely spread carcinogen nitrosodimethylamine and to one of pyrimidine derivatives as a stimulant of regeneration processes. It has been demonstrated that the pyrimidine derivative may prevent the unfavourable metabolic effects occurring at the cellular level (alveolar macrophages of the lungs) and cell organelles (lysosomes and endoplasmic network) in the early stages of the membrane-damaging action of nitrosodimethylamine.
D000818:Animals; D002274:Carcinogens, Environmental; D002462:Cell Membrane / Q000502:physiology*; D004128:Dimethylnitrosamine; D008099:Liver / Q000502:physiology; D008168:Lung / Q000502:physiology; D008247:Lysosomes / Q000502:physiology; D008264:Macrophages / Q000502:physiology; D008297:Male; D008862:Microsomes, Liver / Q000502:physiology; D011013:Pneumonectomy; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D012038:Regeneration / Q000187:drug effects*
D002274:Carcinogens, Environmental; D011743:Pyrimidines; D004128:Dimethylnitrosamine
Funktsional'noe sostoianie kletki i vnutrikletochnykh struktur pri vozdeĭstvii stimuliatorov regeneratsii na rannykh stadiiakh membranotropnogo éffekta khimicheskikh faktorov okruzhaiushcheĭ sredy.