title: The effect of aluminum on the metabolism of embryonic chick bone in tissue culture.
abstract: The effect of aluminum (Al) on bone metabolism was assessed in organ cultures of embryonic chick bone. Al of 10(-4)M and above caused an inhibitory effect on mineralization without inhibiting matrix formation and a stimulative effect on demineralization without stimulating matrix degradation. Therefore, Al was shown to influence the mineral metabolism of bone.
mesh_terms: D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D001862:Bone Resorption / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D002642:Chick Embryo; D008903:Minerals / Q000378:metabolism
chemical_list: D008903:Minerals; D000535:Aluminum; D002118:Calcium