Teratologic evaluation of 3,6-Dichloropicolinic acid in rats and rabbits.
3,6-Dichloropicolinic acid (clopyralid), a new herbicide, was evaluated for teratogenic potential in Fischer 344 rats and New Zealand White rabbits. Rats were given 0, 15, 75, or 250 mg clopyralid/kg/day by gavage on Days 6-15 of gestation while rabbits were given 0, 110, or 250 mg clopyralid/kg/day on Days 6-18 of gestation. Maternal toxicity, as evidenced by decreased body weight gain, was observed among pregnant rats in the 250-mg/kg/day group. No evidence of maternal toxicity was observed among treated rabbits. A teratogenic effect was not detected in either species.
D000014:Abnormalities, Drug-Induced; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005260:Female; D006540:Herbicides / Q000633:toxicity*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010848:Picolinic Acids / Q000633:toxicity*; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D011916:Rats, Inbred F344
D006540:Herbicides; D010848:Picolinic Acids; C011767:clopyralid