Hypertensive crisis induced by metoclopramide in patient with pheochromocytoma.
A hypertensive crisis associated with evidence of catecholamine release was induced following intravenous administration of 10 mg metoclopramide in a woman with pheochromocytoma and in whom the tyramine test was negative. After removal of the tumor, blood-pressure and plasma catecholamine concentrations were not influenced by the administration of metoclopramide. It is suggested that the mechanism of hypertensive crises induced by metoclopramide may not be due to a direct catecholamine releasing effect from the tumor or sympathetic nerve endings, but rather to its presynaptic dopaminergic blocking effect which would indirectly release catecholamines.
D000310:Adrenal Gland Neoplasms / Q000188:drug therapy / Q000503:physiopathology*; D002395:Catecholamines / Q000097:blood; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced* / Q000503:physiopathology; D008787:Metoclopramide / Q000009:adverse effects* / Q000627:therapeutic use; D008875:Middle Aged; D010673:Pheochromocytoma / Q000188:drug therapy / Q000503:physiopathology*
D002395:Catecholamines; D008787:Metoclopramide