[Role of combined administration of alpha-tocopherol and sodium nucleinate in normalizing the phospholipid composition of cardiac muscle in a model of myocardial infarction].
It is shown that combined administrations of alpha-tocopherol and sodium nucleinate lead to normalization of qualitative and quantitative content of phospholipids in the myocardium of rabbits under conditions of an experimental myocardial infarction. The changes obtained are accompanied by a simultaneous limitation of lipid peroxidation activity and by normalization of the phospholipid-phospholipid interrelations. The therapeutic role of the compounds tested is discussed.
D000818:Animals; D002308:Cardiolipins / Q000032:analysis; D002682:Chinchilla; D004359:Drug Therapy, Combination; D005260:Female; D008054:Lipid Peroxides / Q000096:biosynthesis; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D009203:Myocardial Infarction / Q000188:drug therapy*; D009206:Myocardium / Q000032:analysis*; D009696:Nucleic Acids / Q000008:administration & dosage*; D010743:Phospholipids / Q000032:analysis*; D014810:Vitamin E / Q000008:administration & dosage*
D002308:Cardiolipins; D008054:Lipid Peroxides; D009696:Nucleic Acids; D010743:Phospholipids; D014810:Vitamin E; D008315:Malondialdehyde; C013683:sodium nucleinate
Rol' sochetannogo primeneniia al'fa-tokoferola i nukleinata natriia v normalizatsii fosfolipidnogo sostava myshtsy serdtsa pri modelirovanii infarkta miokarda.