A dietary regimen alters hepatocyte plasma membrane lipid fluidity and ameliorates ethinyl estradiol cholestasis in the rat.
A dietary regimen which induces hepatic fatty acyl desaturase activities increases the lipid fluidity of hepatocyte plasma membranes, both in normal rats and in animals treated with ethinyl estradiol to produce cholestasis. In the cholestatic animals the fluidity change is accompanied by a significant increase in bile flow rate of approx. 33%.
D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D002779:Cholestasis / Q000178:diet therapy* / Q000378:metabolism; D004032:Diet; D004997:Ethinyl Estradiol / Q000633:toxicity*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D051381:Rats
D004997:Ethinyl Estradiol