title: Review of 59 patients with hypergonadotrophic amenorrhoea.
abstract: Fifty-nine patients presented with elevated concentrations of gonadotrophins and secondary amenorrhoea before the age of 35 years. Fifty-three underwent laparoscopic examination and primordial follicles were observed in 16. Two others had follicles as they later became pregnant and a third showed biochemical evidence of spontaneous ovulation. There were streak ovaries in 12, two with follicles and three others with chromosomal abnormalities, two being 47XXX and one XO/XX. Two other patients had only one ovary each but no follicles. Chromosomal abnormalities were detected in two further patients one being XO/XX and the other a recombinant. Six patients became pregnant, two of them twice, resulting in four term deliveries and four spontaneous abortions. Three other patients showed biochemical evidence of ovulation; one spontaneously, one after oestrogen therapy and the third after treatment with gonadotrophin releasing hormone analogue.
mesh_terms: D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000175:diagnosis* / Q000209:etiology / Q000235:genetics; D002648:Child; D005260:Female; D006065:Gonadotropins, Pituitary / Q000097:blood*; D006801:Humans; D010049:Ovarian Diseases / Q000150:complications; D010053:Ovary / Q000002:abnormalities; D011247:Pregnancy; D012729:Sex Chromosome Aberrations / Q000150:complications
chemical_list: D006065:Gonadotropins, Pituitary