Is streptokinase safe during menses?
We used intravenous streptokinase to treat a young woman with deep venous thrombosis manifested during her menses. There was no increase in menstrual bleeding, and she was symptom free six months later. Because menstrual endothelium after the first day of menses relies on arteriolar constriction for hemostasis rather than the formation of fibrin, we think that streptokinase may not be contraindicated in thrombotic disorders that occur during menses after the first day.
D000328:Adult; D005260:Female; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008598:Menstruation / Q000187:drug effects*; D013300:Streptokinase / Q000009:adverse effects / Q000627:therapeutic use; D013927:Thrombosis / Q000188:drug therapy*
D006493:Heparin; D013300:Streptokinase