Effects of tranexamic acid and local fibrin deposition of fibrinolysis and granulation tissue formation in preformed cavities.
The effects of locally deposited fibrin and of tranexamic acid-induced antifibrinolysis on forming granulation tissue were studied in the light of a recently developed method for treatment of postoperative fistulas by occlusion with a fibrin clot. Perforated teflon cylinders, either empty or fibrin-filled, were implanted subcutaneously in rats and extracted after 2 weeks. Fibrin deposition was found to stimulate granulation tissue ingrowth into the cylinders but it did not change the fibrinolytic activity in the granulation tissue. A significantly higher fibrinolytic activity was, however, found in the tissue fluid collected from the space between the granulation tissue and the implanted fibrin clot compared to tissue fluid from cylinders implanted empty. Tranexamic acid significantly reduced the fibrinolytic activity on the granulation tissue and delayed lysis of the implanted fibrin clot. It also reduced granulation tissue ingrowth but it did not abolish the positive effects of the clot on granulation tissue formation.
D000818:Animals; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004343:Drug Implants; D005337:Fibrin / Q000627:therapeutic use*; D005342:Fibrinolysis / Q000187:drug effects*; D005402:Fistula / Q000188:drug therapy*; D006097:Granulation Tissue / Q000187:drug effects* / Q000378:metabolism; D006651:Histocytochemistry; D008297:Male; D011183:Postoperative Complications / Q000188:drug therapy*; D051381:Rats; D011919:Rats, Inbred Strains; D014148:Tranexamic Acid / Q000627:therapeutic use*
D003509:Cyclohexanecarboxylic Acids; D004343:Drug Implants; D014148:Tranexamic Acid; D005337:Fibrin