[Effect of phosphodiesterase inhibitors on the membrane potential and respiration of mitochondria].
Effect of papaverine, 3-isobutyl-1-methylxanthine and SQ-20009 was studied. It was shown that papaverine (50 microM) had rotenone--like action on isolated rat liver mitochondria decreasing their membrane potential and blocking respiration upon beta-oxybutyrate oxidation. Papaverine did not practically influence the membrane potential and oxygen consumption upon succinate oxidation. SQ-20009 effect was much less than that of papaverine. 3-isobutyl-1-methylxanthine (50-200 microM) was uneffective at all.
D000818:Animals; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects*; D008930:Mitochondria, Liver / Q000378:metabolism / Q000502:physiology*; D010101:Oxygen Consumption / Q000187:drug effects*; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D051381:Rats
D010726:Phosphodiesterase Inhibitors
Vliianie ingibitorov fosfodiśterazy na membrannyĭ potentsial i dykhanie mitokhondriĭ.