title: Induction of ovulation with human pituitary gonadotrophin. Twelve years' experience.
abstract: Twelve years' experience in the therapeutic use of human pituitary gonadotrophins in 74 patients with anovulation is reviewed. Of these 74 patients, 54 conceived on at least one occasion. A new development, the use of radioimmunoassays for oestrone-3-glucuronide and pregnanediol-3-glucuronide to monitor responses, has been shown to be as effective as the more laborious chemical methods which were previously used. The adoption of radioimmunoassay monitoring allows the simultaneous treatment of up to five patients, and will markedly reduce existing waiting lists for this treatment.
mesh_terms: D004970:Estrone / Q000031:analogs & derivatives / Q000652:urine; D005260:Female; D006065:Gonadotropins, Pituitary / Q000008:administration & dosage*; D006801:Humans; D008137:Longitudinal Studies; D010062:Ovulation Induction / Q000379:methods*; D011247:Pregnancy; D011276:Pregnanediol / Q000031:analogs & derivatives / Q000652:urine; D011863:Radioimmunoassay; D014463:Ultrasonography
chemical_list: D006065:Gonadotropins, Pituitary; C022270:pregnanediol-3 alpha-glucuronide; C015856:estrone-3-glucuronide; D004970:Estrone; D011276:Pregnanediol