The potentiation of arterial contraction with platelet activating factor.
The incubation of porcine carotid arteries with platelet activating factor induces a potentiation of contraction when the artery is subsequently challenged with 100 mM KCl compared with control preparations. This potentiation of arterial contraction is not observed when extracellular Ca2+ influx or prostaglandin metabolism is inhibited.
D000818:Animals; D002147:Calmodulin / Q000494:pharmacology; D002339:Carotid Arteries / Q000187:drug effects / Q000502:physiology*; D005480:Flurbiprofen / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D010972:Platelet Activating Factor / Q000502:physiology*; D011189:Potassium Chloride / Q000494:pharmacology; D012965:Sodium Chloride / Q000494:pharmacology; D013552:Swine; D014700:Verapamil / Q000494:pharmacology
D002147:Calmodulin; D010972:Platelet Activating Factor; D012965:Sodium Chloride; D005480:Flurbiprofen; D011189:Potassium Chloride; D014700:Verapamil