An evaluation of the mutagenic potential of cyanamide using the micronucleus test.
The bone-marrow micronucleus assay was used in mice to evaluate the mutagenic potential of cyanamide administered per os at doses of 10, 49 and 247 mg/kg. Bone-marrow smears were examined to find the incidence of micronucleated cells in 1000 polychromatic erythrocytes (PCE) and 1000 normochromatic erythrocytes ( NCE ). The ratio of NCE /PCE was also scored. No increase in the incidence of micronucleated polychromatic erythrocytes and no difference in the ratio NCE /PCE for the groups treated with cyanamide (10 and 49 mg/kg) were observed. The group treated with the highest dose of cyanamide (247 mg/kg) did, however, show an NCE /PCE ratio lower than the control group (p less than 0.05).
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002467:Cell Nucleus / Q000187:drug effects / Q000648:ultrastructure; D003484:Cyanamide / Q000633:toxicity*; D003486:Cyanides / Q000633:toxicity*; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects*
D003486:Cyanides; D003484:Cyanamide; D003520:Cyclophosphamide