title: Chromosomal location of human metallothionein genes: implications for Menkes' disease.
abstract: Human metallothioneins are encoded by a complex multigene family. The chromosomal location of these genes has been determined by gel transfer hybridization analysis of the DNA from human-rodent cell hybrids. Chromosome 16 contains a cluster of metallothionein sequences, including two functional metallothionein I genes and a functional metallothionein II gene. The remaining sequences, including a processed pseudogene, are dispersed to at least four other autosomes. The absence of metallothionein sequences from the X chromosome indicates that Menkes' disease, an X-linked disorder of copper metabolism, affects metallothionein expression by a trans-acting mechanism.
mesh_terms: D000818:Animals; D001928:Brain Diseases, Metabolic / Q000235:genetics*; D002874:Chromosome Mapping; D002902:Chromosomes, Human, 16-18; D003300:Copper / Q000378:metabolism; D006224:Cricetinae; D003412:Cricetulus; D006801:Humans; D006822:Hybrid Cells; D007706:Menkes Kinky Hair Syndrome / Q000235:genetics*; D008668:Metallothionein / Q000235:genetics*; D051379:Mice
chemical_list: D003300:Copper; D008668:Metallothionein