Effects of prazosin and propranolol on serum lipids in patients with essential hypertension.
The effects of prazosin and propranolol on total serum cholesterol concentration, low-density lipoprotein and high-density lipoprotein cholesterol fractions, and serum triglyceride concentration were compared in a crossover study in 29 patients with mild to moderate essential hypertension. All patients received polythiazide at a constant dose throughout control and drug treatment periods. Comparable blood pressure reduction was achieved with prazosin (9.3 +/- 7.1 mg per day) and propranolol (183.6 +/- 154.5 mg per day). Prazosin administration was associated with a significant reduction in the concentrations of total serum cholesterol (-5.5 percent), triglyceride (-20.0 percent), and low-density lipoprotein cholesterol (-10.1 percent). High-density lipoprotein cholesterol concentration increased (+8.0 percent) as did the ratio high-density lipoprotein: total cholesterol (+14.1 percent). No significant changes in any of the serum lipid fractions were observed during propranolol administration.
D001794:Blood Pressure / Q000187:drug effects; D002784:Cholesterol / Q000097:blood*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D011139:Polythiazide / Q000627:therapeutic use; D011224:Prazosin / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use*; D011799:Quinazolines / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood*
D008074:Lipoproteins; D011799:Quinazolines; D014280:Triglycerides; D011139:Polythiazide; D002784:Cholesterol; D011433:Propranolol; D011224:Prazosin