Tumorigenic potential of endoperoxide analogs.
The endoperoxide analogs known as U-46619 and U-44069 significantly enhanced the carcinoma formation and cellular atypicality initiated by a chemical carcinogen in mice. Studies of DNA radioactivity demonstrated that endoperoxides exerted their cocarcinogenic action by stimulating DNA synthesis. Thus, they play an important role in tumor cell proliferation.
D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000648:ultrastructure; D002471:Cell Transformation, Neoplastic / Q000187:drug effects; D003043:Cocarcinogenesis; D004261:DNA Replication / Q000187:drug effects; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D008854:Microscopy, Electron; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology*
D011450:Prostaglandin Endoperoxides, Synthetic; D008748:Methylcholanthrene; C028429:U 44069; D019796:15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid