title: [Mitochondrial pathology].
abstract: Three adult patients with mitochondrial disease underwent clinical-morphological studies which demonstrated a diffuse and marked defect in mitochondria. The characteristic clinical picture of "ophthalmoplegia plus", a slow progression of the disease, the quantitative and structural changes in the mitochondria of muscle fibers justified the diagnosis of mitochondrial disease.
mesh_terms: D000293:Adolescent; D000328:Adult; D004734:Energy Metabolism; D005260:Female; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008931:Mitochondria, Muscle / Q000378:metabolism / Q000648:ultrastructure*; D009886:Ophthalmoplegia / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D013577:Syndrome
vernacular_title: Mitokhondrial'naia patologiia.