Model of chronic pancreatitis in the dog.
A model of chronic pancreatitis was developed and characterized in the dog. Pancreatitis was produced by infusion of oleic acid through a cannula in the accessory pancreatic duct. Biochemical changes included early and marked increases in serum amylase and lipase activities which returned to base line within 3 weeks, at which time the dogs were clinically normal. In dogs euthanatized within 2 weeks, pathologic changes included massive necrosis and hemorrhage, cystic spaces filled with fluid, and abscesses. Histologic features revealed acute exudative pancreatitis with pancreatic atrophy and fibrosis. In dogs killed between weeks 3 to 12, changes included: marked atrophy with remaining acini surrounded by remnants consisting of collapsed stroma, blood vessels, and pancreatic ducts; marked coarse fibrosis with scattered inflammatory cells and occasional acinar tissue; and large irregular pseudocysts.
D000818:Animals; D001284:Atrophy / Q000662:veterinary; D001803:Blood Transfusion / Q000662:veterinary; D002908:Chronic Disease; D004195:Disease Models, Animal; D004283:Dog Diseases / Q000201:enzymology / Q000473:pathology* / Q000628:therapy; D004285:Dogs; D005260:Female; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000201:enzymology / Q000473:pathology / Q000628:therapy / Q000662:veterinary*; D010949:Plasma
D009829:Oleic Acids; D019301:Oleic Acid