Ultrastructural survey and tissue analysis of human livers after a 6-month course of etretinate.
A prospective study of the histology and ultrastructure of liver biopsies and analysis of liver tissue for retinoid was performed in twenty psoriasis patients treated with etretinate for 6 months. Nonspecific ultrastructural changes were noted in several liver specimens. Etretinate was detected in all samples. We find no significant hepatotoxicity after a 6 month course of etretinate. Body fat is probably a more important site than the liver for storage of etretinate.
D000328:Adult; D000368:Aged; D001707:Biopsy, Needle; D005050:Etretinate / Q000378:metabolism / Q000627:therapeutic use* / Q000633:toxicity; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D011446:Prospective Studies; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors
D005050:Etretinate