Alloxan-induced hyperglycemia increases progestin and androgen accumulation by isolated rabbit follicles in vitro.
Follicles isolated from Alloxan-treated rabbits and incubated in vitro, accumulated more progesterone and testosterone than those from saline-treated rabbits. LH augmented the accumulation of these 2 steroids. By contrast, the estradiol response to LH stimulation by follicles from Alloxan-induced hyperglycemic rabbits was diminished when compared to follicles from saline-treated rabbits. Ovaries from hyperglycemic rabbits also appeared to have more cystic follicles.
D000496:Alloxan / Q000494:pharmacology*; D000728:Androgens / Q000378:metabolism*; D000818:Animals; D005260:Female; D006943:Hyperglycemia / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000494:pharmacology; D006080:Ovarian Follicle / Q000378:metabolism*; D011372:Progestins / Q000378:metabolism*; D011817:Rabbits
D000728:Androgens; D011372:Progestins; D000496:Alloxan; D007986:Luteinizing Hormone