title: [Excessive gynecomastia in boys. Effective medical treatment using danazol (Winobanin)].
abstract: The purpose of this study was to provide a medical alternative to mastectomy in boys with excessive breast development. Eleven boys with bilateral gynecomastia, ranging in size between 9 X 7 cm and 3 X 3 cm in diameter, were treated with 200 mg of Danazol daily for 6 months. This therapy led to a reduction in breast size between 3 X 3 cm and 1,5 X 1,5 cm. The antigonadotropic action of Danazol was documented by inhibition of basal gonadotropin secretion, by disappearance of normal sleep dependent rhythms and by a reduced pituitary response to stimulation. Simultaneously, plasma testosteron secretion was suppressed without reduction of testicular volumes. In all patients the hypothalamo-pituitary gonadal axis normalized within 67 months after termination of therapy and no relapse was observed over a control period up to 26 months. The continuing regression after Danazol treatment emphasizes the effectiveness of drug therapy as an alternative regimen to surgical intervention.
mesh_terms: D000293:Adolescent; D002648:Child; D003613:Danazol / Q000008:administration & dosage / Q000627:therapeutic use*; D006177:Gynecomastia / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011245:Pregnadienes / Q000627:therapeutic use*; D013737:Testis / Q000473:pathology; D013739:Testosterone / Q000097:blood; D013997:Time Factors
chemical_list: D011245:Pregnadienes; D013739:Testosterone; D003613:Danazol
vernacular_title: Ausgeprägte Gynäkomastie beim Jungen. Möglichkeit einer effektiven medikamentösen Therapie mit Danazol (Winobanin).