New 75Se-labeled radiopharmaceuticals: 2. Selenium derivatives of aralkylamines.
Two 75Se-labeled aralkylamines, 2-(3,4-methylenedioxyphenylseleno)ethylamine hydrochloride (75Se-6) and 1-methylseleno-1-phenylethylmethylamine hydrochloride (75Se-9), were prepared with high specific activity applying two different chemical means starting from [75Se]selenious acid. Tissue distribution studies in rats show high uptake in the lungs with lung/blood ratios of 27/1 and 2.3/1 at 10 min for compound 75Se-9 and 75Se-6, respectively. High adrenal uptake and adrenal-to-blood ratio (15/1 at 2 h) of compound 75Se-9 were observed. This study indicates that aralkylamines can accommodate a Se group and still show high uptake by the organs that contain appreciable amount of dopaminergic receptors.
D000313:Adrenal Medulla / Q000000981:diagnostic imaging*; D000818:Animals; D005260:Female; D007554:Isotopes; D011868:Radioisotopes; D011877:Radionuclide Imaging; D051381:Rats; D011919:Rats, Inbred Strains; D012643:Selenium; D014018:Tissue Distribution
D007554:Isotopes; D011868:Radioisotopes; D012643:Selenium