Chemotactic and phagocytic responses of human alveolar macrophages to activated complement components.
Human alveolar macrophages (AMs) migrated toward and aggregated to C5a but not toward C5a-deficient serum. Human AMs from cigarette smokers migrated significantly farther than did AMs from nonsmokers. Human AMs phagocytized Escherichia coli opsonized with activated C3. Immunoglobulin G was not required for phagocytosis. Human AMs demonstrate chemotaxis and aggregation to C5a. Further, human AMs can phagocytize bacteria coated with activated C3.
D002633:Chemotaxis; D003167:Complement Activation; D003176:Complement C3 / Q000276:immunology; D003182:Complement C5 / Q000276:immunology; D015936:Complement C5a; D006801:Humans; D008264:Macrophages / Q000276:immunology*; D009895:Opsonin Proteins / Q000276:immunology; D010587:Phagocytosis; D012907:Smoking
D003176:Complement C3; D003182:Complement C5; D009895:Opsonin Proteins; D015936:Complement C5a