Selective increase in acylation of 1-acylglycerophosphorylcholine in livers of rats and mice by peroxisome proliferators.
Rats were fed a diet containing p-chlorophenoxyisobutyric acid (clofibric acid). Activity of microsomal 1-acylglycerophosphorylcholine (1-acyl-GPC) acyltransferase in liver was increased approx. 3-fold by the treatment with clofibric acid. The treatment of rats with clofibric acid did not increase activity of microsomal 2-acyl-GPC acyltransferase. Feeding a diet containing 2,2'-(decamethylenedithio)diethanol (tiadenol), di(2-ethylhexyl)phthalate or acetylsalicylic acid also resulted in a selective increase in the activity of 1-acyl-GPC acyltransferase in rat liver. Treatment with clofibric acid increased the activity of 1-acyl-GPC acyltransferase in liver of mouse as well as rat, but did not change the activity in liver of guinea-pig. The relative rate of acylation of 1-acyl-GPC with various acyl-CoAs by hepatic microsomes was not changed by the treatment of rats with clofibric acid.
D008243:1-Acylglycerophosphocholine O-Acyltransferase; D000215:Acylation; D000217:Acyltransferases / Q000378:metabolism; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D002994:Clofibrate / Q000031:analogs & derivatives*; D002995:Clofibric Acid / Q000494:pharmacology*; D005233:Fatty Alcohols / Q000494:pharmacology; D005997:Glycerylphosphorylcholine / Q000031:analogs & derivatives* / Q000378:metabolism; D006168:Guinea Pigs; D000960:Hypolipidemic Agents / Q000494:pharmacology; D008099:Liver / Q000378:metabolism*; D008244:Lysophosphatidylcholines; D008297:Male; D051379:Mice; D008830:Microbodies / Q000187:drug effects*; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains
C014307:1-acylglycerylphosphorylcholine; D005233:Fatty Alcohols; D000960:Hypolipidemic Agents; D008244:Lysophosphatidylcholines; C004568:tiadenol; D002995:Clofibric Acid; D005997:Glycerylphosphorylcholine; D000217:Acyltransferases; D008243:1-Acylglycerophosphocholine O-Acyltransferase; C031076:2-acylglycerophosphocholine acyltransferase; D002994:Clofibrate; D001241:Aspirin