title: Inhibition of nerve fiber regeneration in cultured sympathetic neurons by local, high potassium.
abstract: Distal regeneration of neurites from cultured sympathetic neurons of newborn rats was stunted by exposure to local, high K+ (20 mM), only when more proximal neurite regions and the cell bodies were exposed to a normal K+ concentration (5 mM). Neurites grew luxuriantly and extensively when exposure to high K+ was uniform over the entirety of the neurons. Thus, neurite growth can be strongly influenced by regional variations in K+ which are probably within the naturally occurring range, especially during development and regeneration.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D003864:Depression, Chemical; D008564:Membrane Potentials; D009416:Nerve Regeneration / Q000187:drug effects*; D011188:Potassium / Q000494:pharmacology* / Q000502:physiology; D051381:Rats; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000254:growth & development
chemical_list: D011188:Potassium