The saturation and isomerization of dietary fatty acids and the respiratory properties of rat heart mitochondria.
Weanling rats were fed semi-purified diets containing 15% by weight of either corn oil, a high oleic acid safflower oil, lard or hydrogenated soybean oil. Significant changes in the fatty acid composition of heart mitochondrial preparations were induced by these dietary fats. Despite these changes in membrane composition, no effects on the respiratory properties of the mitochondria were observed. These results suggest that mitochondrial membranes adapt to changes in dietary fatty acids in a way which prevents changes in their functional properties.
D000244:Adenosine Diphosphate / Q000378:metabolism; D000818:Animals; D004041:Dietary Fats / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism; D007536:Isomerism; D008297:Male; D008929:Mitochondria, Heart / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
D004041:Dietary Fats; D005227:Fatty Acids; D000244:Adenosine Diphosphate