Nucleolar alterations of myocardial cells and glomerular epithelial cells in rats after a single administration of adriamycin.
A single i.v. injection of 15 mg/kg of adriamycin into 4-week-old male Sprague-Dawley rats induced nucleolar segregation in myocardial cells and renal glomerular epithelial cells but not in tubular epithelial cells or glomerular endothelial cells.
D000818:Animals; D002466:Cell Nucleolus / Q000187:drug effects*; D004317:Doxorubicin / Q000633:toxicity*; D004848:Epithelium / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D007678:Kidney Glomerulus / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D009206:Myocardium / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains
D004317:Doxorubicin