title: Prevention of urinary tract infection during intermittent catheterization.
abstract: We studied prospectively 40 patients with recent spinal cord injuries to determine the effectiveness of the combination of oral methenamine and an intravesicular acidifying agent for prevention of urinary tract infection during intermittent catheterization. The incidences of bacteriuria and symptomatic urinary tract infections were significantly less in the treated group. This combination appears to be a safe, effective means to reduce pyelonephritis in spinal cord injury patients on intermittent catheterization.
mesh_terms: D001437:Bacteriuria / Q000517:prevention & control; D002951:Citrates / Q000008:administration & dosage*; D006801:Humans; D008333:Mandelic Acids / Q000627:therapeutic use*; D008709:Methenamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D011446:Prospective Studies; D013119:Spinal Cord Injuries / Q000628:therapy; D014546:Urinary Catheterization / Q000009:adverse effects / Q000379:methods*; D014552:Urinary Tract Infections / Q000209:etiology / Q000382:microbiology / Q000517:prevention & control*
chemical_list: D002951:Citrates; D008333:Mandelic Acids; C026485:hemiacidrin; C023055:methenamine mandelate; D008709:Methenamine