title: The epidermal permeability barrier. Comparison between in vivo and in vitro lipid structures.
abstract: The epidermal permeability barrier is established by the lamellar contents of membrane-coating granules which are discharged into the intercellular space of the stratum granulosum and form continuous lipid layers in the stratum corneum. Artificial lipid systems, prepared with a composition similar to that found in stratum granulosum and stratum corneum, were able to form a lamellar phase. These systems show dense line thickness and center-to-center spacing comparable to those found in membrane-coating granules and intercellular layers. The significance of lipid composition in relation to barrier function is discussed and a model showing the molecular arrangement of the lipid structures in the epidermal barrier is proposed.
mesh_terms: D000818:Animals; D002463:Cell Membrane Permeability; D004817:Epidermis / Q000502:physiology* / Q000648:ultrastructure; D008051:Lipid Bilayers; D008081:Liposomes; D008563:Membrane Lipids / Q000502:physiology*; D051379:Mice; D008954:Models, Biological; D008967:Molecular Biology; D009940:Organoids / Q000502:physiology; D010743:Phospholipids / Q000502:physiology*
chemical_list: D008051:Lipid Bilayers; D008081:Liposomes; D008563:Membrane Lipids; D010743:Phospholipids