Synthesis of shrimp red pigment-concentrating hormone analogs and their biological activity in locusts.
Two analogs of the red pigment-concentrating hormone (RPCH) have been synthesized by the solid-phase method: [Thr6]-RPCH (I) and [Tyr4, Thr6]-RCPH (II). Analog I has the same amino acid composition as the second adipokinetic hormone (AKH-II) isolated from locust corpora cardiaca. Bioassay for lipid-mobilizing activity in adult male locusts gave the following increases in hemolymph lipid content: AKH-I, 3.5; I, 2.4; II, 2.9. The biological response shown by I lends support to the conclusion that its sequence is that of the presumptive AKH-II. Replacement of Phe in position 4 by Tyr does not reduce the adipokinetic response.
D000818:Animals; D001681:Biological Assay; D033364:Decapoda / Q000502:physiology*; D006110:Grasshoppers / Q000502:physiology*; D006458:Hemolymph / Q000187:drug effects / Q000378:metabolism; D007202:Indicators and Reagents; D007447:Invertebrate Hormones / Q000138:chemical synthesis*; D050356:Lipid Metabolism
D007202:Indicators and Reagents; D007447:Invertebrate Hormones