title: Role of Tromaril as anti-prostaglandin drug on blood aqueous barrier.
abstract: In this experimental work, it was observed that after anterior chamber paracentesis there was more effusion of protein into the anterior chamber. Pretreatment with aspirin/indomethacin and a new drug, enfenamic acid (Tromaril), decreased this trauma-induced increase in aqueous protein content. It was further observed that this inhibition was more marked with Tromaril pretreatment in comparison with other drugs. Prostaglandin-mediated disruption of blood aqueous barrier can also be decreased with Tromaril pretreatment. Tromaril, a prostaglandin synthetase inhibitor, may help us to control the reactions to surgical ocular trauma and other ocular inflammatory diseases.
mesh_terms: D000818:Animals; D001082:Aqueous Humor / Q000032:analysis / Q000187:drug effects*; D001769:Blood / Q000187:drug effects; D005123:Eye / Q000098:blood supply; D005136:Eye Proteins / Q000032:analysis; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011817:Rabbits; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
chemical_list: D005136:Eye Proteins; D011448:Prostaglandin Antagonists; D062367:ortho-Aminobenzoates; C019126:enfenamic acid