title: The complement component C4 in black Americans with type 1 (insulin-dependent) diabetes mellitus.
abstract: The complement component C4 variants C4A 4, C4B 4 and C4B Q0 were found to be significantly increased in 64 black patients with Type 1 (insulin-dependent) diabetes compared with 169 black control subjects, yielding relative risks of 3.3, 2.9 and 3.4, respectively. The increased frequencies of C4B 4 and C4B Q0 in black Type 1 diabetic patients are similar to those found in Caucasoid Type 1 diabetic patients. The data suggest that Type 1 diabetes in black Americans may be partially due to admixture of genes from whites.
mesh_terms: D000328:Adult; D044383:Black People; D003181:Complement C4 / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000235:genetics*; D006801:Humans; D010641:Phenotype; D012306:Risk; D014481:United States; D044465:White People; D001741:Black or African American
chemical_list: D003181:Complement C4