title: Ultrastructural study of iron deposition in the eccrine sweat glands of patients with iron overload.
abstract: An ultrastructural study of eccrine sweat glands was carried out on three patients with iron overload (two with idiopathic haemochromatosis and one with transfusional haemosiderosis). In all three patients small electron-dense particles were seen in both eccrine sweat glands and macrophages. They appeared primarily in the clear cells of the eccrine sweat glands as membrane-bound irregularly shaped bodies, and were shown to contain iron by energy dispersive X-ray microanalysis. Iron aggregates in and around sweat glands were also seen on light microscopy.
mesh_terms: D000328:Adult; D004439:Eccrine Glands / Q000378:metabolism* / Q000648:ultrastructure; D004577:Electron Probe Microanalysis; D005260:Female; D006432:Hemochromatosis / Q000378:metabolism* / Q000473:pathology; D006486:Hemosiderosis / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D013545:Sweat Glands / Q000378:metabolism*
chemical_list: D007501:Iron