Methylmethacrylate and atrioventricular conduction in dogs.
The effect of intravenous methylmethacrylate (MMA) on atrioventricular conduction times was studied in dogs, utilizing His-bundle electrograms. Dogs were anesthetized with halothane or enflurane; then MMA in a dose causing minimal to profound hemodynamic changes was administered and His-bundle electrograms, and arterial, pulmonary artery, and central venous pressures were recorded. This experimental model did not demonstrate a prolongation of atrioventricular conduction intervals which could be implicated as etiologic in MMA-induced dysrhythmias.
D000769:Anesthesia, Inhalation; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D001283:Atrioventricular Node / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004562:Electrocardiography; D006329:Heart Conduction System / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D020366:Methylmethacrylate; D008768:Methylmethacrylates / Q000633:toxicity*; D013997:Time Factors
D008768:Methylmethacrylates; D020366:Methylmethacrylate