Concentrations of doxorubicin in renal interstitial fluid after peripheral intravenous and intrarenal artery infusion in dogs.
Concentrations of doxorubicin-hydrochloride in renal interstitial fluid were compared following peripheral and intrarenal artery infusion of 2 milligrams per kilogram body weight using a diffusion chamber model. After intra-arterial application, the mean peak concentration in renal interstitial fluid was approximately 30 times higher than that after intravenous infusion (66.49 and 2.38 nanograms per milliliter respectively). After peripheral application, the concentrations in serum and renal interstitial fluid, as well as the cumulative urinary excretion, were measured until day 7 of the experiment, and the pharmacokinetic parameters were calculated. The diffusion chamber model used proved itself to be suitable for simultaneous and continuous measurement of cytostatic drug concentrations in serum and renal interstitial fluid.
D000818:Animals; D004285:Dogs; D004317:Doxorubicin / Q000008:administration & dosage / Q000378:metabolism*; D004343:Drug Implants; D005110:Extracellular Space / Q000378:metabolism*; D007261:Infusions, Intra-Arterial; D007263:Infusions, Parenteral; D007668:Kidney / Q000378:metabolism* / Q000473:pathology; D007700:Kinetics; D008567:Membranes, Artificial; D010539:Permeability; D012077:Renal Artery
D004343:Drug Implants; D008567:Membranes, Artificial; D004317:Doxorubicin