[Importance of using hematoporphyrine derivate in the destruction of adenocarcinomas with Nd Yag or argon lasers].
As the hematoporphyrin derivate photochemical properties have been known for many years, this study tries to appreciate the laser beam effect on experimental tumors previously sensitized by H.P.D. Colic adenocarcinoma cells are grafted on mice. On the 10th day tumors are photocoagulated. Previously the mice were divided into 4 groups: G 1: H.P.D. intra-venous injection on the 9th day followed by a Nd Yag laser photocoagulation; G 2: Nd Yag laser only; G 3: H.P.D. intra-venous injection on the 9th day followed by an argon laser photocoagulation; G 4: argon laser only. The G 1 and G 2 study shows that, when Nd Yag laser is used, H.P.D. alters the type of necrosis obtained and the action depth. The G3 and G4 study shows that, when argon laser is used, H.P.D. does not alter the type of necrosis obtained but greatly increases the action depth.
D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000818:Animals; D001128:Argon; D006415:Hematoporphyrins / Q000627:therapeutic use*; D053685:Laser Therapy; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009336:Necrosis; D009374:Neoplasms, Experimental / Q000473:pathology / Q000601:surgery
D006415:Hematoporphyrins; D001128:Argon
Intérêt de l'utilisation de l'hématoporphyrine dérivée pour la destruction d'adénocarcinomes par le laser N.D. Yag ou le laser á argon.