Intracellular distribution and properties of cathepsin B in the rat retina and its inhibition by a cytosolic fraction.
The intracellular distribution and properties of cathepsin B in the rat retina are similar to those of cathepsin B in other mammalian tissues. The specific activity of cathepsin B was highest in the mitochondrial-lysosomal fraction [1650 +/- 450 pmole mg-1 protein hr-1 (mean +/- S.D.)]. Inhibition of cathepsin B activity by a cytosol fraction of retina is also described.
D000818:Animals; D002401:Cathepsin B; D002403:Cathepsins / Q000032:analysis / Q000037:antagonists & inhibitors / Q000378:metabolism*; D003600:Cytosol / Q000032:analysis / Q000201:enzymology; D006863:Hydrogen-Ion Concentration; D008247:Lysosomes / Q000201:enzymology; D008928:Mitochondria / Q000201:enzymology; D051381:Rats; D012160:Retina / Q000032:analysis / Q000201:enzymology*
D002403:Cathepsins; D002401:Cathepsin B