Dyskinesia and psychosis in a patient following baclofen withdrawal.
A paraplegic man with no history of psychiatric illness developed psychosis and dyskinesia following abrupt withdrawal of baclofen; the symptoms resolved 72 hours after resumption of the drug. The psychosis and dyskinesia may have been a manifestation of baclofen's alteration of cerebral dopaminergic mechanisms.
D000328:Adult; D001418:Baclofen / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009069:Movement Disorders / Q000139:chemically induced*; D009128:Muscle Spasticity / Q000188:drug therapy / Q000209:etiology; D010146:Pain / Q000188:drug therapy / Q000209:etiology; D010264:Paraplegia / Q000150:complications; D011605:Psychoses, Substance-Induced / Q000209:etiology*; D013375:Substance Withdrawal Syndrome / Q000209:etiology*
D001418:Baclofen