title: Differences in evolutionary stability among mammalian H1 subtypes. Implications for the roles of H1 subtypes in chromatin.
abstract: The metabolic and developmental properties that differentiate five H1 subtypes of the mouse, H1a-H1e, are shown to have been conserved in the course of mammalian evolution. The structures of the subtypes, however, as judged by their mobilities in two-dimensional gel electrophoresis, have been conserved to varying extents. H1a and H1c have undergone the most structural variation, each having a different electrophoretic mobility in every species examined. H1b is much less varied, while H1d and H1e are invariant by these electrophoretic criteria. These results suggest that H1a and -c differ fundamentally from H1b, -d, and -e in their interactions with other chromatin components. It is suggested that this difference is in the ability to promote the coiling of 10-nm chromatin fibers into higher order chromatin structures.
mesh_terms: D000818:Animals; D002417:Cattle; D002843:Chromatin / Q000648:ultrastructure*; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006657:Histones / Q000502:physiology*; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013552:Swine
chemical_list: D002843:Chromatin; D006657:Histones