[Digoxin-amiodarone interaction].
Digoxin plasma levels and digoxin erythrocytic membrane content have been evaluated in 39 patients treated with digoxin and amiodarone in a fixed dose for more than 3 months. The results were compared with those obtained in a group of patients treated with digoxin alone and matched for age, renal function and digoxin daily dose in micrograms/kg body weight. Digoxin plasma levels and digoxin erythrocytic content were significantly higher in patients treated with amiodarone than in controls, thus confirming the interaction between digoxin and amiodarone. The relation between digoxin plasma levels and digoxin bound to erythrocytic membranes--as a marker of the deep tissue accumulation--was not different in patients treated with digoxin or with digoxin + amiodarone, further indicating that amiodarone may not increase digoxin plasma levels by means of a displacement of the glycoside from tissues. The clinical significance of the interaction is still undefined.
D000328:Adult; D000368:Aged; D000638:Amiodarone / Q000494:pharmacology*; D001572:Benzofurans / Q000494:pharmacology*; D004077:Digoxin / Q000097:blood*; D004347:Drug Interactions; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011955:Receptors, Drug / Q000378:metabolism
D001572:Benzofurans; D011955:Receptors, Drug; D004077:Digoxin; D000638:Amiodarone
L'interazione tra digossina ed amiodarone.