title: Enhancement of paracetamol induced hepatotoxicity by prior treatment with carboxymethylcellulose.
abstract: This study was undertaken to determine if interactions of toxicological significance might occur during treatment of mice with paracetamol (P) and carboxymethylcellulose (CMC). P (300 mg/kg) administration induced only slight hepatic morphologic changes and lowered hepatic reduced glutathione (GSH) to 40% of the level in controls, when measured 1 hour after treatment. Intraperitoneal pretreatment with CMC (1% in NaC1, 20 ml/kg), significantly decreased GSH concentration (to 19% of controls) and severely enhanced hepatic injury. Such an interaction is of considerable significance since both CMC and P are widely used substances in experimental pharmacology and clinical practice.
mesh_terms: D000082:Acetaminophen / Q000633:toxicity*; D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology / Q000503:physiopathology*; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008297:Male; D008747:Methylcellulose / Q000031:analogs & derivatives*; D051379:Mice; D013997:Time Factors
chemical_list: D000082:Acetaminophen; D008747:Methylcellulose; D005978:Glutathione; D002266:Carboxymethylcellulose Sodium