Detection limits for a GC determination of methanol and methylene chloride residues on film-coated tablets.
A GC assay was developed that quantitates methanol and methylene chloride at the lowest detectable levels for this mode of analysis. A statistical limit of detection was determined for both methanol and methylene chloride. This method is sensitive and reliable for detecting possible residues of these solvents on film-coated tablets.
D002849:Chromatography, Gas / Q000379:methods; D006843:Hydrocarbons, Chlorinated / Q000032:analysis*; D000432:Methanol / Q000032:analysis*; D008752:Methylene Chloride / Q000032:analysis*; D013607:Tablets / Q000032:analysis
D006843:Hydrocarbons, Chlorinated; D013607:Tablets; D008752:Methylene Chloride; D000432:Methanol