Ovarian leiomyoma with hilus cell hyperplasia that caused virilization.
A 68-year-old woman had noted gradual virilization and depression for 3 years. Examination revealed a 10-cm right pelvic mass. Plasma testosterone was substantially elevated (1,082 ng/dl), but urinary ketosteroid and ketogenic steroid excretion was normal. Laparotomy revealed a 10-cm mass that replaced the right ovary and weighed 210 g. Histologic analysis revealed a leiomyoma and proliferation of hilus cells in the periphery of the mass. The plasma testosterone decreased postoperatively to 45 ng/dl. We believe that this is the first report of an ovarian leiomyoma associated with hilus cell hyperplasia that caused virilization.
D000368:Aged; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007889:Leiomyoma / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000473:pathology*; D010053:Ovary / Q000473:pathology*; D013739:Testosterone / Q000097:blood; D014770:Virilism / Q000209:etiology*
D013739:Testosterone