The effect of aluminum on the metabolism of embryonic chick bone in tissue culture.
The effect of aluminum (Al) on bone metabolism was assessed in organ cultures of embryonic chick bone. Al of 10(-4)M and above caused an inhibitory effect on mineralization without inhibiting matrix formation and a stimulative effect on demineralization without stimulating matrix degradation. Therefore, Al was shown to influence the mineral metabolism of bone.
D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D001862:Bone Resorption / Q000187:drug effects; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D002642:Chick Embryo; D008903:Minerals / Q000378:metabolism
D008903:Minerals; D000535:Aluminum; D002118:Calcium