[Pharmaceutic and biopharmaceutic evaluation of acetylaminonitropropoxybenzene (Falimint). A Biotransformation of the active agent].
2-Acetamino-4-nitropropoxybenzene is metabolized almost completely. Till now in urine of man seven components have been detected. The main way of metabolism is the oxidation of the propoxy group to a carboxyl group. Also the deacetylated compound of this acid has been found to a certain extent. A further metabolite is supposed to be oxidized in the side chain in another way. In a higher extent dealkylation to 2-acetamino-4-nitrophenol takes place which is eliminated probably in conjugation with glucuronic acid. Free 2-acetamino-4-nitrophenol and 2-amino-4-nitrophenol respectively are only detectable in traces. Deacetylation of 2-amino-4-nitropropoxybenzene takes place only in a very small extent. Till now metabolites with reduced nitro group haven't been found.
D000083:Acetanilides / Q000378:metabolism*; D001702:Biopharmaceutics; D001711:Biotransformation; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D006801:Humans
D000083:Acetanilides; C031846:5'-nitro-2'-propoxyacetanilide
Zur pharmazeutischen und biopharmazeutischen Begutachtung von Acetylaminonitropropoxybenzolum (Falimint). 4. Mitteilung: Biotransformation des Wirkstoffes.