Effects of trimethyltin on the immune system of rats.
Treatment with trimethyltin (TMT) induced atrophy of the thymus, spleen and lymph nodes within 2 days, but no changes in the bone marrow were observed. Atrophy of thymus and spleen did not occur in adrenal-ectomized rats treated with TMT. Antibody responses to sheep erythrocytes (SRBC) and proliferative responses of spleen lymphocytes to phytohemagglutinin (PHA), concanavalin A (ConA) and lipopolysaccharides (LPS) were suppressed significantly in treated rats. Delayed hypersensitivity to oxazalone, natural killer (NK) cell activity and the phagocytic activity of peritoneal macrophages (PEM) were not affected significantly.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D005260:Female; D006968:Hypersensitivity, Delayed; D007109:Immunity / Q000187:drug effects*; D007694:Killer Cells, Natural / Q000187:drug effects; D008221:Lymphoid Tissue / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014220:Trialkyltin Compounds / Q000633:toxicity*; D014298:Trimethyltin Compounds / Q000633:toxicity*
D014220:Trialkyltin Compounds; D014298:Trimethyltin Compounds; C040533:trimethyltin chloride