[Cytogenetic effect of barbiturate anesthetizing substances in a human peripheral blood leukocyte culture].
It is found that hexenal and sodium thiopental in vitro produced a two-fold increase of frequency of chromosome aberrations as compared with the control and this effect was not dose-dependent. The anesthetics under study affected in vitro 3H-thymidine incorporation into DNA of lymphocytes, and a ten-fold hexenal dose intensified 3H-thymidine incorporation. The frequency of chromosome aberrations in vivo was at the level of the spontaneous mutation after use of sodium thiopental and slightly increased hexenal.
D001463:Barbiturates / Q000494:pharmacology*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004247:DNA / Q000096:biosynthesis; D006591:Hexobarbital / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D007432:Intraoperative Period; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects; D010835:Phytohemagglutinins / Q000494:pharmacology; D013874:Thiopental / Q000494:pharmacology
D001463:Barbiturates; D010835:Phytohemagglutinins; D004247:DNA; D006591:Hexobarbital; D013874:Thiopental
Tsitogeneticheskiĭ éffekt anesteziruiushchikh veshchestv barbituratovogo riada v kul'ture leĭkotsitov perifericheskoĭ krovi cheloveka.