Fosfomycin-induced protoplasts and L-forms of Staphylococcus aureus.
The potency of fosfomycin (60 micrograms/ml) to induce bacterial L-forms and protoplasts was studied on two strains of Staphylococcus aureus. On osmotically appropriate agar, L-colonies could be grown and repeatedly transferred to fresh media. The L-forms were sensitive to tetracycline and resistant to penicillin. Protoplasts were produced by treatment of S. aureus in broth for more than 6 h.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005578:Fosfomycin / Q000494:pharmacology*; D007740:L Forms / Q000187:drug effects*; D011523:Protoplasts / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000648:ultrastructure
D000900:Anti-Bacterial Agents; D005578:Fosfomycin