title: [The chemistry of indium complexes].
abstract: There are no complexes of indium known to occur naturally in the human. Several radiopharmaceuticals labelled with In-111 or In-113m have been investigated for their application to localization studies. Most of the indium radiopharmaceuticals have a weak thermodynamic stability and, therefore, no specificity. It is known that such compounds are converted in vivo to In-labelled transferrin. Experiments to increase the thermodynamic stability, thereby leading to an increase in specificity have been followed up in two directions: Modification of polyaminocarboxylic acids (e.g. EDTA, DTPA) by reaction with a benzene diazonium salt or by substitution with methylene phosphoric acid instead of acetic acid in the EDTA molecule. Application of lipid soluble chelates of indium-111 for blood cell labelling (e.g. erythrocytes, leucocytes and platelets). The results are promising.
mesh_terms: D001773:Blood Cells / Q000000981:diagnostic imaging; D002614:Chelating Agents / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D006801:Humans; D007204:Indium / Q000378:metabolism*; D007554:Isotopes; D011877:Radionuclide Imaging; D013816:Thermodynamics
chemical_list: D002614:Chelating Agents; D007554:Isotopes; D007204:Indium
vernacular_title: Chemie der Indiumkomplexe.