title: Glucose-6-phosphate dehydrogenase deficiency in Southeast Asian refugees entering the United States.
abstract: Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited disorder of red blood cell metabolism. Affected individuals may suffer a severe hemolytic crisis when treated with primaquine, an antimalarial. A survey of 966 male Southeast Asian refugees determined that 50 (5.2%) were G6PD-deficient. This prevalence suggests that a G6PD assay should be performed prior to primaquine therapy in this high-risk population.
mesh_terms: D000328:Adult; D001210:Asia, Southeastern / Q000208:ethnology; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000453:epidemiology*; D006801:Humans; D008288:Malaria / Q000188:drug therapy; D008297:Male; D011319:Primaquine / Q000009:adverse effects / Q000627:therapeutic use; D012036:Refugees; D014481:United States
chemical_list: D011319:Primaquine