Aluminum in the joint tissues of chronic renal failure patients treated with regular hemodialysis and aluminum compounds.
We studied the concentrations of aluminum in the articular tissues of 5 hemodialysed patients treated with aluminum compounds. Aluminum crosses the synovial barrier, is found in synovial fluid (SF) and accumulates in the joint structures (synovial membrane and joint cartilage). The concentrations found in synovial tissue were 2.7 to 10 times control values, in SF 2.5 to 8 times the control concentrations and in cartilage 2.6 times the control concentrations. Transmission electron microscopy showed localization of aluminum in the lysosomal structures and wavelength dispersive microprobe analysis showed aluminum in cellular components associated with phosphate. The possible toxicity of aluminum to joints merits further investigations.
D000535:Aluminum / Q000032:analysis*; D000536:Aluminum Hydroxide / Q000009:adverse effects*; D001842:Bone and Bones / Q000032:analysis; D002358:Cartilage, Articular / Q000032:analysis; D005260:Female; D006801:Humans; D007592:Joint Diseases / Q000209:etiology; D007596:Joints / Q000032:analysis*; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008247:Lysosomes / Q000032:analysis; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D006435:Renal Dialysis / Q000009:adverse effects*; D013582:Synovial Fluid / Q000032:analysis; D013583:Synovial Membrane / Q000032:analysis / Q000648:ultrastructure; D014018:Tissue Distribution
D000536:Aluminum Hydroxide; D000535:Aluminum