title: [Use of cyclophosphane and amphotericin B on patients with disseminated forms of chondrosarcoma].
abstract: The results of amphotericin B and cyclophosphamide treatment of 10 cases of chondrosarcoma are discussed. A marked (50-90%) regression of tumors and metastases and complete remission for 3-18 months were observed in 9 cases. Decompression laminectomy resulted in regression of neurologic symptoms in a case of chondrosarcoma disseminated to the spinal column with concomitant constriction of the spinal cord. This effect was obtained during remission following chemotherapy.
mesh_terms: D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000188:drug therapy*; D002813:Chondrosarcoma / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004341:Drug Evaluation; D004357:Drug Synergism; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy
chemical_list: D000666:Amphotericin B; D003520:Cyclophosphamide
vernacular_title: Primenenie tsiklofosfana i amfoteritsina "B" u bol'nykh s rasprostranennymi formami khondrosarkomy.