Immunological analysis of women with repeated spontaneous abortions.
The study deals with 9 women with recurrent abortions who do not possess the blocking factor which is present during normal pregnancy and which inhibits, nonspecifically, a cellular cytotoxicity reaction in vitro. Electrophoresis of the women's serum revealed an abnormal glycoprotein, migrating in the alpha-globulin zone, which gives a precipitate with an anti-gamma-globulin serum after mercaptoethanol treatment. These last two findings may indicate a possible abortion.
D000026:Abortion, Habitual / Q000276:immunology*; D000022:Abortion, Spontaneous / Q000276:immunology; D002850:Chromatography, Gel; D003602:Cytotoxicity, Immunologic; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007122:Immunoelectrophoresis; D007165:Immunosuppression Therapy; D011247:Pregnancy
D006680:HLA Antigens