Effects of paraquat on peroxide metabolism enzymes and lipid peroxidation in the rat.
Investigation has been made of how the LD50 and LD100 of PQ influence the peroxide metabolism enzymes and lipid peroxidation in organ homogenates and blood samples of the rat. The peroxide metabolism enzyme activities were changed in a concentration dependent manner. In general, the effect of the lower doses of PQ on the superoxide dismutase, catalase activities and lipid peroxidation are increased. The glutathione peroxidase activity was decreased. Higher doses of PQ enhanced all of enzyme activities and lipid peroxidation studied.
D000818:Animals; D002374:Catalase / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005979:Glutathione Peroxidase / Q000378:metabolism; D007928:Lethal Dose 50; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008297:Male; D010269:Paraquat / Q000494:pharmacology*; D010545:Peroxides / Q000378:metabolism*; D051381:Rats; D013482:Superoxide Dismutase / Q000378:metabolism
D008054:Lipid Peroxides; D010545:Peroxides; D002374:Catalase; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D010269:Paraquat