title: Pharmacokinetics of digoxin alone and in the presence of indomethacin therapy.
abstract: The effects of maintenance indomethacin therapy on single dose digoxin pharmacokinetics and dynamics were studied in six healthy volunteers with normal renal function. Indomethacin did not alter the elimination half-life, systemic clearance or distribution of digoxin. No pharmacodynamic interaction as assessed by changes in the systolic time intervals QA2 and LVET was found. This study does not lend support for a significant digoxin-indomethacin interaction in man.
mesh_terms: D000328:Adult; D004077:Digoxin / Q000097:blood / Q000378:metabolism*; D004347:Drug Interactions; D005260:Female; D006207:Half-Life; D006801:Humans; D007213:Indomethacin / Q000097:blood / Q000494:pharmacology*; D007700:Kinetics; D008297:Male
chemical_list: D004077:Digoxin; D007213:Indomethacin