The role of Mycobacterium xenopi in human disease.
Mycobacterium xenopi is infrequently recognized as a cause of pulmonary infection. We isolated this organism from 28 patients over a 3-yr period. It was nonpathogenic in 19 and pathogenic in 9. Clinical illness occurred in middle-aged men with other chronic pulmonary diseases. Therapy was associated with clinical improvement, but most isolates were resistant to first-line antituberculosis drugs. The prevalence of M. xenopi varies geographically, but in the province of Ontario, it is second to M. avium-intracellulare as the most common nontuberculous mycobacterial pathogen.
D000328:Adult; D000368:Aged; D000995:Antitubercular Agents / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000150:complications; D008297:Male; D008875:Middle Aged; D009165:Mycobacterium Infections, Nontuberculous / Q000188:drug therapy / Q000382:microbiology; D009170:Nontuberculous Mycobacteria / Q000187:drug effects; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy / Q000382:microbiology*
D000995:Antitubercular Agents