Genotoxicity of garlic, turmeric and asafoetida in mice.
The genotoxic effects of orally administered garlic and turmeric were evaluated in bone-marrow cells of mice by performing the micronucleus test. Another spice, asafoetida, was tested for the induction of sister-chromatid exchanges (SCEs) in spermatogonia of mice. Results of the micronucleus test with garlic and turmeric were not significantly different from control values. Orally administered asafoetida, however, showed a weak SCE-inducing effect in spermatogonia.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D003212:Condiments / Q000633:toxicity*; D005737:Garlic / Q000633:toxicity*; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects*; D010946:Plants, Medicinal; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013093:Spermatogonia / Q000187:drug effects