The effect of an oral therapeutic single-dose of griseofulvin on polymorphonuclear leukocyte migration in a casein gradient.
In a previous study, polymorphonuclear (PMN) leukocyte chemotaxis in vitro was inhibited by therapeutic concentrations of griseofulvin. In the present investigation, PMN migration in a casein gradient was studied in a cell suspension containing serum collected before and after a therapeutic peroral single-dose of griseofulvin. The PMN migration in vitro was not influenced significantly by the presence of griseofulvin-containing serum. It is suggested that peroral griseofulvin treatment has negligible effect on PMN chemotaxis in vitro.
D000284:Administration, Oral; D001682:Biological Availability; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006118:Griseofulvin / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D006801:Humans; D009504:Neutrophils / Q000187:drug effects
D006118:Griseofulvin