A new allele at the Mup-1 locus controlling an electrophoretic variant of major urinary proteins in mice.
The present study showed that the presence or absence of a new component of major urinary proteins (Mups), which is found in MOA mice, an inbred strain of Mus musculus molossinus (Japanese wild mice), is controlled by a single codominant gene locus. The linkage analysis shows that the locus is on chromosome 4, where the Mup-1 locus is assigned; its alleles, Mup-1a, and Mup-1b determine two phenotypic forms of MUPs in laboratory mice (M. m. domesticus). Recombination values between the locus and other loci on chromosome 4, such as brown (b), Pgm-2, and Gpd-1 are compatible with the gene order, Mup-1-b-Pgm-2-Gpd-1, on chromosome 4. Thus, it is concluded that the locus is identical to Mup-1 and it is proposed that Mup-1c be designated as the allele that determines a third phenotypic form of MUPs in MOA mice.
D000483:Alleles; D000818:Animals; D004587:Electrophoresis, Agar Gel; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains / Q000235:genetics*; D011506:Proteins / Q000235:genetics*
D011506:Proteins; C035737:major urinary proteins