Drug conjugation in clinical toxicology.
Conjugation is an important mechanism for the rapid inactivation and extensive removal of drugs and poisons from the body, and as such it is of major significance in clinical toxicology. The capacity for conjugation of some drugs is large, but with others, saturation may occur with overdosage or even high therapeutic doses. Glutathione conjugation is an important mechanism of protection against toxicity produced by heavy metals, alkylating agents and some compounds which undergo metabolic activation.
D000328:Adult; D001711:Biotransformation; D005260:Female; D005965:Glucuronates / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D006801:Humans; D008658:Inactivation, Metabolic; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D012459:Salicylates / Q000378:metabolism; D020156:Salicylic Acid; D013431:Sulfates / Q000378:metabolism; D014116:Toxicology
D005965:Glucuronates; D004364:Pharmaceutical Preparations; D012459:Salicylates; D013431:Sulfates; D005978:Glutathione; D020156:Salicylic Acid; D005998:Glycine