Decreased sensitivity of neurons in the basolateral amygdala to dopamine and noradrenaline iontophoresis after a kindling stimulus.
The depressant effects of iontophoretically applied dopamine and noradrenaline on glutamate-induced neuronal firing in the amygdaloid complex of cats were significantly reduced 1 and 2 h after induction of a local epileptiform afterdischarge of the kind used in kindling. Neuronal excitation by glutamate and depression by GABA were not significantly changed. This suggests that kindling is associated with a reduction of the inhibitory effects of endogenous catecholamines.
D000679:Amygdala / Q000187:drug effects* / Q000502:physiology; D000818:Animals; D002415:Cats; D004298:Dopamine / Q000378:metabolism / Q000494:pharmacology*; D005971:Glutamates / Q000378:metabolism / Q000494:pharmacology; D007478:Iontophoresis; D007696:Kindling, Neurologic; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000378:metabolism / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism / Q000494:pharmacology
D005971:Glutamates; D005680:gamma-Aminobutyric Acid; D004298:Dopamine; D009638:Norepinephrine