Effects of misonidazole on circadian rhythm in oxygen uptake of mouse brain homogenates.
Changes in mouse brain homogenates oxygen uptake are determined, following intraperitoneal injection of misonidazole (100 or 500 mg/kg), at one of four circadian stages. An analysis of periodic regressions of the observed data shows that the circadian variability of brain oxygen utilization is affected by the timing of drug administration.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002940:Circadian Rhythm / Q000187:drug effects*; D008297:Male; D051379:Mice; D008920:Misonidazole / Q000494:pharmacology*; D009593:Nitroimidazoles / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*
D009593:Nitroimidazoles; D008920:Misonidazole