Induction of nasal late-phase reactions by insufflation of ragweed-pollen extract.
We studied changes in NAC in 17 ragweed-sensitive individuals after intranasal ragweed-challenge testing. All patients experienced immediate symptoms of sneezing, rhinorrhea, and nasal congestion that were associated with marked decreases in NAC (mean = 68%). In 10 trials patients also experienced late (greater than 0 hr) symptoms of nasal congestion with or without rhinorrhea; the mean late NAC decrease in this group was 42%. In contrast, no late symptoms were noted in nine trials, and the mean NAC decreased 5% in this group (p less than 0.003). Attempts to passively transfer immediate or late nasal sensitivity to one individual by spraying the nasal cavity with IgE antibody-containing serum, by packing the nose with cotton pledgets soaked in serum, by injecting serum directly into the inferior turbinate, and by transfusion with IgE-containing serum were not successful. We conclude that symptomatic late-phase reactions occur in the nose after intranasal challenge in about 50% of patients and that these symptomatic reactions can be confirmed objectively by rhinomanometry.
D000328:Adult; D000403:Airway Resistance; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis*; D007073:Immunoglobulin E / Q000096:biosynthesis; D009297:Nasal Mucosa / Q000098:blood supply / Q000378:metabolism; D009299:Nasal Provocation Tests / Q000295:instrumentation / Q000379:methods; D011058:Pollen / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis* / Q000276:immunology / Q000503:physiopathology; D012912:Sneezing
D007073:Immunoglobulin E