Acute changes in dopamine metabolism in the medio-basal hypothalamus following adrenalectomy.
During the first hour following adrenalectomy the alpha-MPT-induced disappearance of dopamine was increased in the arcuate nucleus compared to that in sham-operated rats. In a number of other brain regions of both adrenalectomized and sham-adrenalectomized rats only stress-induced changes were observed in catecholamine utilization. These data suggest that corticosterone selectively modulates dopamine utilization in the medio-basal hypothalamus.
D000315:Adrenalectomy; D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000378:metabolism; D003345:Corticosterone / Q000097:blood; D004298:Dopamine / Q000378:metabolism*; D004837:Epinephrine / Q000378:metabolism; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D008473:Median Eminence / Q000378:metabolism; D008781:Methyltyrosines / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats
D008781:Methyltyrosines; C022260:alpha-methyltyrosine methyl ester; D004298:Dopamine; D003345:Corticosterone; D009638:Norepinephrine; D004837:Epinephrine