Possible recurrence of amiodarone pulmonary toxicity following corticosteroid therapy.
Amiodarone hydrochloride, a new antiarrhythmic agent, has been associated with pulmonary toxicity characterized by cough, dyspnea and diffuse pulmonary infiltrates. We describe a case of fibrosing alveolitis, diagnosed by lung biopsy, in a patient receiving amiodarone which responded to corticosteroid therapy. The pulmonary symptoms recurred after discontinuing corticosteroids, five months after amiodarone was stopped, and were associated with a persistent amiodarone level. To our knowledge, this recurrence of amiodarone pulmonary toxicity has not been reported previously.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000638:Amiodarone / Q000009:adverse effects*; D001145:Arrhythmias, Cardiac / Q000150:complications / Q000188:drug therapy; D001572:Benzofurans / Q000009:adverse effects*; D001706:Biopsy; D006801:Humans; D008168:Lung / Q000187:drug effects* / Q000473:pathology; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D012008:Recurrence
D000305:Adrenal Cortex Hormones; D001572:Benzofurans; D000638:Amiodarone