[Seasonal characteristics of the hepatotoxicity of tetracycline].
Seasonal characteristics of the liver response to repeated tetracycline administrations in doses inducing significant affections of the liver were studied in 84 male albino rats. The most pronounced inhibition of bile secretion, synthesis and secretion of bile acids, excretion of cholesterol and secretion of bilirubin, especially its non-conjugated fraction, was observed in autumn and winter. In spring and summer, these changes were less pronounced. The decrease in the total content of bile acids in autumn and winter was mainly due to the decrease in the level of the tauro-acids, while in spring and summer, it was mainly due to the decrease in the level of bile acids conjugated with glycine. It was concluded that hepatotoxicity of tetracycline was significantly influenced by the seasonal characteristics.
D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D001647:Bile Acids and Salts / Q000032:analysis; D001663:Bilirubin / Q000032:analysis; D002784:Cholesterol / Q000032:analysis; D008099:Liver / Q000187:drug effects*; D008297:Male; D051381:Rats; D012621:Seasons; D012636:Secretory Rate / Q000187:drug effects; D013752:Tetracycline / Q000008:administration & dosage / Q000633:toxicity*
D001647:Bile Acids and Salts; D002784:Cholesterol; D013752:Tetracycline; D001663:Bilirubin
Sezonnye osobennosti gepatotoksichnosti tetratsiklina.