Atrial flutter and maprotiline: case report.
Atrial flutter developed in an 80-year-old woman after 10 days of treatment with maprotiline at therapeutic concentrations. This cardiac irregularity is extremely rare with the conventional antidepressants. Evidence is reviewed to suggest that the likely mechanism was reuptake blockade of noradrenergic amines stimulating reentrant excitation within the atria.
D000368:Aged; D000873:Anthracenes / Q000009:adverse effects*; D001282:Atrial Flutter / Q000139:chemically induced*; D003866:Depressive Disorder / Q000188:drug therapy; D005260:Female; D006801:Humans; D008376:Maprotiline / Q000009:adverse effects* / Q000097:blood
D000873:Anthracenes; D008376:Maprotiline