Synthesis of some 1.3.4-thiadiazoles of possible antimicrobial activity.
Different new esters of 5-aryl-1,3,4-thiadiazol-2-ylcarbazic acid and dithiocarbazic acid were prepared. In addition, the synthesis of 2-(N,N'-dialkylcarboxy)hydrazino-5-aryl-1,3,4-thiadiazoles is described. IR and NMR data of the new compounds are discussed. Some of these compounds showed a reasonable activity against Gram positive bacteria and fungi.
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013830:Thiadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D013830:Thiadiazoles