title: [Increase in the effectiveness of irradiating sarcoma-45 in rats using metronidazole].
abstract: A single exposure to ionizing radiation combined with the administration of metronidazole accelerated the regression of sarcoma-45 and increased the number of animals with fully regressed tumors as compared to control rats exposed to radiation alone. The maximum effect was registered when tumors were irradiated 90 min after the administration of metronidazole. With fractionated irradiation the radiosensitizing effect of metronidazole was less pronounced.
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D005720:Gamma Rays / Q000627:therapeutic use; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage*; D009368:Neoplasm Transplantation; D011879:Radiotherapy Dosage; D051381:Rats; D012513:Sarcoma, Experimental / Q000532:radiotherapy*; D013997:Time Factors
chemical_list: D008795:Metronidazole
vernacular_title: Povyshenie éffektivnosti oblucheniia sarkomy-45 krys metronidazolom.