title: Adjuvant immunotherapy for melanoma.
abstract: Adjuvant immunotherapy was administered to 84 lymph-node-negative and 25 lymph-node-positive melanoma patients. This active specific homologous cell protein preparation was given after aggressive surgery and given over 2 years. Projected and observed survival rates are presented as well as other clinical and pathologic characteristics such as female-to-male ratio, site of primary, level and depth of invasion. The projected 5-year survival rates are 90% for all stage I with 89% for females and 94% for males. Lower extremity stage I projected 5-year survival rate was 88% for all, 87% for females, and 100% for males. The projected 5-year survival rate for stage II was 68% overall and 100% for lower extremity. Only two of five patients with an unknown primary have expired. All of these results are improved over expected survival. Hopefully a randomized prospective study will be stimulated to ascertain the basis for this improvement.
mesh_terms: D000368:Aged; D000951:Antigens, Neoplasm / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007167:Immunotherapy; D008197:Lymph Node Excision; D008297:Male; D008545:Melanoma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D012878:Skin Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*
chemical_list: D000951:Antigens, Neoplasm