Localization of cysteine sulfinic acid uptake sites in rat brain by quantitative autoradiography.
In vitro autoradiography was employed to localize and quantify Na-dependent binding sites of [35S]cysteic acid (CA), an analog of cysteine sulfinic acid (CSA). The heterogeneous anatomical distribution and pharmacological specificity of [35S]CA differs from that of the glutamate/aspartate marker D-[3H]aspartate, and appears to represent a specific uptake site for CSA. These results suggest that CSA may act as an excitatory transmitter in the central nervous system.
D000603:Amino Acids, Sulfur / Q000378:metabolism*; D000818:Animals; D001345:Autoradiography; D001665:Binding Sites; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry; D003544:Cysteic Acid / Q000032:analysis / Q000378:metabolism*; D003545:Cysteine / Q000031:analogs & derivatives* / Q000032:analysis / Q000378:metabolism; D008297:Male; D018377:Neurotransmitter Agents; D051381:Rats
D000603:Amino Acids, Sulfur; D018377:Neurotransmitter Agents; D003544:Cysteic Acid; D003545:Cysteine; C013461:cysteine sulfinic acid