Cycloheximide challenge of mice bearing subcutaneous tumours, with observations on heparin treatment.
Mice bearing large subcutaneous transplants of ovarian teratocarcinoma succumb when given large doses of cycloheximide, whereas animals with equally large subcutaneous Ehrlich tumours are resistant to this treatment. Adequate dosage of heparin is life-saving in cycloheximide-treated, teratoma-bearing mice. The results are discussed in the context of previous work, and one tentative suggestion made is that cycloheximide interferes with the mechanism for release of endogenous heparin which is an essential component of the host response to a growing teratocarcinoma.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D003513:Cycloheximide / Q000633:toxicity*; D005260:Female; D006493:Heparin / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000378:metabolism; D014176:Protein Biosynthesis; D012878:Skin Neoplasms / Q000378:metabolism
D006493:Heparin; D003513:Cycloheximide