[Synthesis of peptides with gastrinlike activity. Studies on the structure-activity relationship of the natural hormone human little gastrin I].
To identify the role of the block of glutamic acid residues characteristic for the gastrin molecule, a series of shortened peptides related to the human little-gastrin-I sequence were synthesized. The biological activities of these gastrin peptides strongly suggest in the pentaglutamic acid sequence a specific information for a pronounced amplification of the hormonal activity.
D000595:Amino Acid Sequence; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002855:Chromatography, Thin Layer / Q000379:methods; D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000494:pharmacology*; D005971:Glutamates / Q000502:physiology; D006801:Humans; D010446:Peptide Fragments / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
D005755:Gastrins; D005971:Glutamates; D010446:Peptide Fragments; C013550:gastrin 17
Synthese von Gastrin-aktiven Peptiden. Untersuchungen zur Struktur-Wirkungsbeziehung des natürlichen Hormons Human-Little-Gastrin-I.