Derivatives of 4,5,6,7-tetrahydro-7,8,8-trimethyl-3-phenylamino-4,7-methano-2H-ind azo le with hypotensive and hypoglycemic activities. II.
A series of N-substituted thioureas (II) and some ureas (III) were synthesized in excellent yields by reaction of 4,5,6,7-tetrahydro-7,8,8-trimethyl-3-phenylamino-4,7-methano-2H-indazole with alkyl, aryl isothiocyanates and isocyanates, respectively. On the whole compounds (II) and (III) showed hypotensive and in some cases hypoglycemic activity in rats. Effects on heart rate in rats, infiltration anesthesia in mice and antiacetylcholine activity in vitro are also reported.
D000109:Acetylcholine / Q000037:antagonists & inhibitors; D000779:Anesthetics, Local / Q000138:chemical synthesis; D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D006339:Heart Rate / Q000187:drug effects; D007004:Hypoglycemic Agents / Q000138:chemical synthesis*; D066298:In Vitro Techniques; D007191:Indazoles / Q000138:chemical synthesis*; D051379:Mice; D011720:Pyrazoles / Q000138:chemical synthesis*; D051381:Rats
D000779:Anesthetics, Local; D000959:Antihypertensive Agents; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007191:Indazoles; D011720:Pyrazoles; D000109:Acetylcholine