The efficacy and pharmacokinetics of sodium salicylate in post-operative dental pain.
Sodium salicylate, 537 mg and 1074 mg were compared in a double-blind cross-over study in 24 patients with post-operative pain following removal of impacted lower third molars. No significant analgesic effect was observed after either dose of sodium salicylate, either overall or at any time point during the 5 h investigation period. Peak plasma concentrations of salicylate after 537 mg were observed at 30 min after dosage, whereas peak plasma salicylate concentrations after 1074 mg sodium salicylate occurred at 45 min after dosage.
D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008964:Molar, Third; D010149:Postoperative Pain / Q000188:drug therapy*; D012980:Sodium Salicylate / Q000097:blood / Q000627:therapeutic use*; D014081:Tooth Extraction
D012980:Sodium Salicylate