Genetic study of an orthopedic referral center.
A prospective study of patients seen at the Shriners Hospital for Crippled Children, Houston Unit, showed that there is a substantial genetic component to orthopedic disorders. A mean of 25% of new patients and 46% of specialty clinic patients had orthopedic diseases of genetic etiology. The respective single gene component was 7.2% and 12.9%. Rare disorders were observed, and some of these are discussed. The results indicate that genetic counseling should be an integral part of orthopedic care.
D000293:Adolescent; D001848:Bone Diseases, Developmental / Q000000981:diagnostic imaging / Q000453:epidemiology / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005817:Genetic Counseling; D006776:Hospitals, Pediatric; D006782:Hospitals, Special; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008297:Male; D009985:Orthopedics; D010375:Pedigree; D011446:Prospective Studies; D011859:Radiography; D012189:Retrospective Studies; D013781:Texas