Effects of verapamil on preservation of renal function after ischemia: functional and ultrastructural study.
The effects of hypothermia and verapamil, a calcium antagonist, on preventing renal damage after 60 minutes of ischemia were studied in rats. Hypothermia alone provided the best protection, and pretreatment with verapamil failed to afford protective effects in normothermic and hypothermic ischemia, findings further supported by electron microscopic studies.
D000818:Animals; D001806:Blood Urea Nitrogen; D005260:Female; D007036:Hypothermia, Induced; D007511:Ischemia / Q000473:pathology / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply / Q000503:physiopathology*; D007687:Kidney Tubules, Proximal / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil