title: Anti-inflammatory activity of amino acyl benzoates.
abstract: Nineteen new piperazino or morpholino amino acyl benzoates were synthesized and screened against carrageenin induced oedema in albino rats. Several compounds of the series showed potent anti-inflammatory activity. Compound 10 was found to be the most potent. This compound was further evaluated in detail and compared with phenylbutazone for its relative anti-inflammatory potency and ulcerogenic liability. The compound, in addition, was compared with acetyl salicylic acid for its analgesic activity. This compound showed potent ant-inflammatory activity with minimal ulcerogenic liability.
mesh_terms: D062365:Aminobenzoates / Q000494:pharmacology*; D000700:Analgesics; D000818:Animals; D000893:Anti-Inflammatory Agents; D001241:Aspirin / Q000494:pharmacology; D002855:Chromatography, Thin Layer; D010437:Peptic Ulcer / Q000139:chemically induced; D010653:Phenylbutazone / Q000494:pharmacology; D011480:Protease Inhibitors; D051381:Rats
chemical_list: D062365:Aminobenzoates; D000700:Analgesics; D000893:Anti-Inflammatory Agents; D011480:Protease Inhibitors; D010653:Phenylbutazone; D001241:Aspirin