Effect of diisopropyl 1,3-dithiolan-2-ylidenemalonate on experimental fatty livers in chicks.
The effect of diisopropyl 1,3-dithiolan-2-ylidenemalonate (NKK-100) on experimental fatty livers was investigated in chicks administered an antithyroid agent plus synthetic estrogen or in estrogenized, starved-refed chicks. NKK-100 was added at levels of 250, 500, 1000, and 1500 mg/kg diet. Liver weight was significantly decreased by administration of NKK-100 at 1500 mg/kg diet in the estrogen-administered chicks. Liver lipid content and liver lipid deposition were significantly and inversely decreased with increasing NKK-100 concentration in the diet in the estrogen administered chicks. Plasma transaminase activity, which was elevated by the estrogen administration, was reduced by the administration of NKK-100. These results suggest that NKK-100 may be of value in preventing fatty livers in poultry.
D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D001835:Body Weight / Q000187:drug effects; D002645:Chickens / Q000378:metabolism*; D004028:Dienestrol / Q000009:adverse effects / Q000031:analogs & derivatives; D004958:Estradiol / Q000009:adverse effects / Q000031:analogs & derivatives; D005234:Fatty Liver / Q000139:chemically induced / Q000378:metabolism / Q000662:veterinary*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011201:Poultry Diseases / Q000139:chemically induced / Q000378:metabolism*; D011441:Propylthiouracil / Q000009:adverse effects; D013876:Thiophenes / Q000494:pharmacology*
D013876:Thiophenes; D004958:Estradiol; D011441:Propylthiouracil; C023889:isoprothiolane; C034731:dienestrol diacetate; D001219:Aspartate Aminotransferases; C023482:estradiol dipropionate; D004028:Dienestrol