The effect of the non-steroidal anti-inflammatory drug choline magnesium trisalicylate on gastric mucosal cell exfoliation.
Gastric mucosal cell exfoliation was measured in 10 normal subjects taking choline magnesium trisalicylate (CMT), aspirin and placebo. Both drugs resulted in significantly elevated rates of exfoliation although the serum salicylate levels achieved with aspirin were lower than those achieved by CMT. Side-effects of tinnitus, nausea and increased faecal blood loss were more common while subjects were taking CMT.
D000328:Adult; D001241:Aspirin / Q000009:adverse effects; D002794:Choline / Q000009:adverse effects / Q000031:analogs & derivatives*; D005260:Female; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects*; D006801:Humans; D008297:Male; D011897:Random Allocation; D012459:Salicylates / Q000009:adverse effects* / Q000097:blood; D020156:Salicylic Acid
D012459:Salicylates; C017959:choline magnesium trisalicylate; D002794:Choline; D020156:Salicylic Acid; D001241:Aspirin