Induction of hepatic ornithine decarboxylase by intraperitoneal administration of caffeine in rats.
I.p. administration of caffeine led to a significant increase in hepatic ornithine decarboxylase activity in rats. The enzyme activity reached approximately 10-fold above the control level 5 h after the injection of caffeine at a dose of 150 mg/kg body weight. The high level of ornithine decarboxylase activity remained for 3 h and then decreased rapidly. The enzyme activity of the kidney, however, was not significantly enhanced by the administration of caffeine. The possible mechanism of the caffeine-mediated hepatic ornithine decarboxylase induction is discussed.
D000818:Animals; D002110:Caffeine / Q000008:administration & dosage / Q000633:toxicity*; D004790:Enzyme Induction; D007274:Injections, Intraperitoneal; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D009955:Ornithine Decarboxylase / Q000235:genetics*; D051381:Rats
D002110:Caffeine; D009955:Ornithine Decarboxylase