Hormone and lipogenic enzyme response of the heterozygous dw chick to dietary protein level.
The growth and lipogenic responses of broiler progeny from normal (DwDw male, Dw-female) and dwarf (Dwdw male, Dw-* female) dams to high and low dietary protein were studied. Body weight gains for the DwDw compared to Dwdw male progeny were greater from week 1 to 3, but less from week 7 to 8 and were similar for Dw-* and Dw- females. No significant effects of progeny genotype and no diet X genotype interactions were observed for feed conversion, carcass nitrogen or fat, abdominal fat, growth hormone, triiodothyronine (T3) or thyroxine (T4). Hepatic malic enzyme was elevated in DwDw male progeny compared to Dwdw males, regardless of diet, and was greater in Dw- females than in Dw-* only in response to low dietary protein. Citrate cleavage enzyme was greater in Dw-* than in Dw- females. Low protein resulted in elevated lipogenic enzyme activities, which were more pronounced in progeny of normal dams. A positive relationship observed between malic enzyme activity and T3 levels for all progeny not carrying the dw gene suggests that although circulating levels of thyroid hormones did not differ between genotypes, the cellular response to these hormones was affected by the presence of the dw gene.
D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism; D000818:Animals; D002645:Chickens / Q000235:genetics / Q000378:metabolism*; D004044:Dietary Proteins / Q000008:administration & dosage*; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006579:Heterozygote; D008055:Lipids / Q000096:biosynthesis*; D008099:Liver / Q000201:enzymology*; D008291:Malate Dehydrogenase / Q000378:metabolism; D008297:Male; D012737:Sex Factors; D013963:Thyroid Hormones / Q000097:blood*; D013974:Thyroxine / Q000378:metabolism; D014284:Triiodothyronine / Q000378:metabolism
D004044:Dietary Proteins; D008055:Lipids; D013963:Thyroid Hormones; D014284:Triiodothyronine; D013006:Growth Hormone; D008291:Malate Dehydrogenase; D001275:ATP Citrate (pro-S)-Lyase; D013974:Thyroxine