Structure determination of polysaccharides in Aloe saponaria (Hill.) Haw. (Liliaceae).
Neutral polysaccharides that inhibit carrageenin-induced edema in rats were isolated from the nondialysate of the pulp of Aloe saponaria by gel filtration. These were shown to be a linear polymer of a 1,4-linked beta-D-mannopyranose (mol. wt. 15,000) containing 18% acetyl groups (As mannan 1), and a 1,4-linked alpha-D-mannopyranose polymer containing a single branch on the principal chain consisting of D-glucose residues linked at C-2 and C-4 (mol. wt. 66,000), with 10% acetyl groups (As mannan 2). As mannan 1 inhibited carrageenin-induced hind paw edema at 50 mg/kg ip in rats; As mannan 2 was not tested for pharmacological activity. A crude preparation of both As mannans was effective when given intraperitoneally, but was ineffective when given orally.
D000504:Aloe / Q000032:analysis*; D000818:Animals; D000893:Anti-Inflammatory Agents; D002241:Carbohydrates / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D006868:Hydrolysis; D008297:Male; D008351:Mannans / Q000032:analysis; D008745:Methylation; D008970:Molecular Weight; D010946:Plants, Medicinal / Q000032:analysis*; D011134:Polysaccharides / Q000032:analysis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014783:Viscosity
D000893:Anti-Inflammatory Agents; D002241:Carbohydrates; D008351:Mannans; D011134:Polysaccharides