title: Multiple primary malignant neoplasms.
abstract: A 75-year-old man developed neurilemmoma of the left eighth cranial nerve, adenomatous polyp of the sigmoid colon, adenocarcinoma of the prostate, mixed cell type lymphoma of the right neck, and infiltrating ductal carcinoma of the right breast metachronously during a period of 38 years. The cancer of the right breast occurred 7 years after the long-term stilbestrol treatment of prostatic carcinoma, which suggests a causal relationship between the hormonal therapy and development of breast carcinoma.
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy / Q000473:pathology; D000368:Aged; D001943:Breast Neoplasms / Q000139:chemically induced / Q000473:pathology; D004054:Diethylstilbestrol / Q000009:adverse effects; D006258:Head and Neck Neoplasms / Q000473:pathology; D006801:Humans; D007417:Intestinal Polyps / Q000175:diagnosis; D008223:Lymphoma / Q000473:pathology; D008297:Male; D009378:Neoplasms, Multiple Primary; D009464:Neuroma, Acoustic / Q000175:diagnosis; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology; D012811:Sigmoid Neoplasms / Q000175:diagnosis
chemical_list: D004054:Diethylstilbestrol