Etiologic factors and subsequent reproductive performance in 195 couples with a prior history of habitual abortion.
A diagnostic screening program was applied to 195 couples with a prior history of habitual abortion (i.e., three or more consecutive abortions). Abnormalities were identified in 110 (56%) of the couples. Such identification was significantly more frequent in couples with primary habitual abortion than in couples with secondary habitual abortion (p less than 0.001) and also more frequent in couples with second-trimester abortions than in those with first-trimester abortions (p approximately equal to 0.01). The abnormalities most commonly observed were anomalies of the uterine body (15%), endometrial infections (15%), and cervical incompetence (13%). Hormonal dysfunctions were detected in 5%, and there were chromosomal aberrations in 3% of the couples. The women in the group showing abnormalities were offered surgical or medical treatment, and 80% of those who subsequently conceived carried their pregnancies to term. Among the couples with no abnormal findings, women receiving specific antenatal counseling and psychological support had a pregnancy success rate of 86%, as compared to a success rate of 33% observed in women who were given no specific antenatal care (p less than 0.001).
D000026:Abortion, Habitual / Q000209:etiology* / Q000503:physiopathology; D001424:Bacterial Infections / Q000150:complications; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D004700:Endocrine System Diseases / Q000150:complications; D004716:Endometritis / Q000150:complications; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011247:Pregnancy; D012098:Reproduction; D013076:Sperm Count; D002581:Uterine Cervical Incompetence / Q000150:complications; D014599:Uterus / Q000002:abnormalities