[Pharmacokinetics and toxic properties of chimcocide].
The data on the pharmacokinetics are provided and toxicological characteristics is described in detail of a new highly effective anticoccidal and antitoxoplasmic drug chimcoccide (1,3-bis-/p-chlorbenzylidenamino/guanidine). Chimcoccide is not toxic when applied in prophylactic and therapeutic doses (6 and 12 mg/kg) for coccidosis and toxoplasmosis of animals. It does not disturb the biosynthesis of DNA, RNA, protein or activity of NADP-specific malate dehydrogenase and isocitrate dehydrogenase in organs and tissues of animals. When given in the doses indicated the drug inhibits mitochondrial monoamine oxidase of the brain and liver of rats and chickens.
D000818:Animals; D000981:Antiprotozoal Agents / Q000378:metabolism* / Q000633:toxicity; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects; D004625:Embryo, Nonmammalian; D005260:Female; D005777:Geese; D007700:Kinetics; D007928:Lethal Dose 50; D051379:Mice; D008907:Mink; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D012098:Reproduction / Q000187:drug effects; D014018:Tissue Distribution
D000981:Antiprotozoal Agents
Farmakokinetika i toksicheskie svoĭstva khimkotsida.