title: Catheter-directed low dose streptokinase infusion: a preliminary experience.
abstract: Fifty-six patients with acute or chronic arterial or venous thromboembolic occlusions received treatment with low dose (5,000 U per hour) streptokinase via an indwelling intravascular catheter. Successful clot lysis was achieved in 13 of 14 (92%) postprocedural occlusions that were less than one week in age, in 8 of 11 (73%) atherosclerotic occlusions that were less than six weeks in age, in 2 of 3 (67%) emboli from cardiac thrombi, and in all of the pulmonary emboli and superior vena cava occlusions. In the chronic occlusions, successful thrombus lysis occurred less frequently (8 of 21, 38%). Although the initial objective of fibrinolytic therapy is clot lysis, the long term clinical success depends on the diagnosis and treatment of the underlying cause of the thromboembolism.
mesh_terms: D000328:Adult; D000368:Aged; D000792:Angiography; D001161:Arteriosclerosis / Q000150:complications; D002404:Catheterization / Q000379:methods*; D005260:Female; D006801:Humans; D007261:Infusions, Intra-Arterial / Q000379:methods*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011655:Pulmonary Embolism / Q000188:drug therapy; D013300:Streptokinase / Q000008:administration & dosage*; D013923:Thromboembolism / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D013924:Thrombophlebitis / Q000188:drug therapy
chemical_list: D013300:Streptokinase