Serum lipid and lipoprotein cholesterol grids for cardiovascular risk screening of children.
We determined serum lipid and lipoprotein percentiles from a total community study of 5,250 fasting children (35% black, 65% white), aged 2 to 19 years. A serum turbidity index was used as a rapid, inexpensive screening test for hyper-beta-lipoproteinemia and hyper-pre-beta-lipoproteinemia. Percentile grids for the turbidity index and serum total cholesterol and beta-lipoprotein cholesterol levels may be used for either black or white children. Triglyceride and pre-beta-lipoprotein cholesterol level percentile grids were reported by race because of lower levels in black children, while grids for alpha-lipoprotein cholesterol levels were reported separately by sex for black and white subjects. A five-step method was outlined for screening children for lipid and lipoprotein abnormalities. Those with hyper-beta-lipoproteinemia and hyperpre-beta-lipoproteinemia would be candidates for therapy and indicate screening of other family members, after secondary causes are excluded.
D000293:Adolescent; D000328:Adult; D044383:Black People; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood*; D003327:Coronary Disease / Q000175:diagnosis*; D005215:Fasting; D005260:Female; D006801:Humans; D006951:Hyperlipoproteinemias / Q000175:diagnosis; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008722:Methods; D009391:Nephelometry and Turbidimetry; D014280:Triglycerides / Q000097:blood; D044465:White People
D008055:Lipids; D008074:Lipoproteins; D008079:Lipoproteins, VLDL; D014280:Triglycerides; C030104:lipoprotein cholesterol; D002784:Cholesterol