[Comparison of the effectiveness of preoperative radiation and thermoradiation therapy in treating breast cancer].
Based on an analysis of the 3- and 5-year results of the combined treatment of 865 patients with breast cancer using 4 variants of radiation exposure in the preoperative period the following aspects are discussed: 1) the conventional variant of gamma-beam therapy at summary doses of 40-45 Gy is not an optimum variant of preoperative irradiation; 2) better results are achieved with the preoperative irradiation of the affected breast and zones of regional metastasis at a single dose of 4 Gy and a summary dose of 20 Gy; 3) a marked tendency towards achieving still better results of treatment and a statistically significant decrease in the frequency of distant metastases detected in the first 2 years after treatment are noted with the use of two other variants of preoperative exposure: an increase in the doses in tumor growth zones up to the level which is equivalent to a carcinocidal dose and a short course of preoperative irradiation (20 Gy) under the conditions of local UHF-hyperthermia.
D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D005260:Female; D005720:Gamma Rays / Q000627:therapeutic use; D006801:Humans; D006979:Hyperthermia, Induced; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011300:Preoperative Care; D011867:Radioisotope Teletherapy; D011879:Radiotherapy Dosage; D011897:Random Allocation
Sravnenie éffektivnosti predoperatsionnoĭ luchevoĭ i termoradioterapii pri lechenii raka molochnoĭ zhelezy.