Spread of activity in thick cortical slices.
Slices of the hamster cerebral cortex 700-800 micron thick have been demonstrated to be viable when maintained in a bath perfused with oxygenated CSF at 30 ml/min. In such thick slices activity has been shown to spread over both hemispheres following stimulation of the corpus callosum; and seizure activity, suggestive of epilepsy, can be induced by the inclusion of penicillin, pentylinetetrazole, bicuculline or picrotoxin in the CSF.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D003292:Convulsants / Q000494:pharmacology; D003337:Corpus Callosum / Q000502:physiology; D006224:Cricetinae; D004594:Electrophysiology; D004827:Epilepsy / Q000503:physiopathology; D066298:In Vitro Techniques; D008647:Mesocricetus; D008959:Models, Neurological; D011930:Reaction Time / Q000502:physiology; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D003292:Convulsants; D005680:gamma-Aminobutyric Acid