Prevention of transplacentally induced malignant diseases.
Administration of vitamin A (retinol palmitate) causes a reduction of transplacentally induced leukemias. Subsequent to a transplacental application of ENU, addition of vitamin A as a suspension to drinking water leads to a reduction of leukemia incidence to 50% as well as to a corresponding decrease of this disease as a cause of death. Yet there is no influence of vitamin A on the adenomas of the lung arising in this experimental design.
D000818:Animals; D005038:Ethylnitrosourea; D005260:Female; D007942:Leukemia, Experimental / Q000139:chemically induced / Q000401:mortality / Q000517:prevention & control*; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000401:mortality / Q000517:prevention & control*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D014801:Vitamin A / Q000008:administration & dosage*
D014801:Vitamin A; D005038:Ethylnitrosourea