Acute cytogenetic effect of sterigmatocystin on rat bone-marrow cells in vivo.
The acute cytogenetic effects of sterigmatocystin (SC) on rat bone-marrow cells in vivo were studied. The incidence of chromosome aberrations in bone-marrow cells increased and reached the maximum level at 12 h after an intraperitoneal injection of 10(-1) mM(31.2 mg)/kg body weight of SC and decreased gradually to the original level after 96 h. A dose-response relationship was observed between the dose of 10(-6) and 1 mM. The chromosome aberrations consisted of chromatid breaks and gaps, the distribution of breaks and gaps within chromosomes (Nos. 1 and 2) was similar to that induced by a carcinogen, 7,12-dimethyl-benz[a]anthracene.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D002869:Chromosome Aberrations; D002874:Chromosome Mapping; D004305:Dose-Response Relationship, Drug; D005260:Female; D051381:Rats; D013241:Sterigmatocystin / Q000633:toxicity*; D014966:Xanthenes / Q000633:toxicity*
D014966:Xanthenes; D013241:Sterigmatocystin