Late occurrence of malignancy in a ganglioneuroma 19 years following radiation therapy to a neuroblastoma.
Neuroblastoma is a common solid tumor of childhood. Maturation to a ganglioneuroma or regression has been reported to occur spontaneously or following minimal treatment. Malignant degeneration of such a ganglioneuroma is extremely rare. We present a report of a malignant tumor arising in a ganglioneuroma 19 years following abdominal radiation therapy for neuroblastoma.
D000008:Abdominal Neoplasms / Q000473:pathology* / Q000532:radiotherapy; D000328:Adult; D005260:Female; D005729:Ganglioneuroma / Q000473:pathology*; D006801:Humans; D007223:Infant; D009135:Muscular Diseases / Q000473:pathology*; D009447:Neuroblastoma / Q000473:pathology* / Q000532:radiotherapy; D013160:Splenic Neoplasms / Q000532:radiotherapy; D013997:Time Factors