Ultrastructural alterations in hexafluoroacetone-induced testicular atrophy in the rat.
Testicular atrophy was induced in rats by dermal application of hexafluoroacetone (HFA) at 39 or 130 mg/kg/day for 14 days, but not at a dosage of 13 mg/kg/day. Affected germ cells were mostly spermatids and to a much lesser extent spermatocytes; spermatogonia were unaffected. Late spermatids were retained in Sertoli cells and showed degenerative changes. Sertoli cells exhibited cytoplasmic vacuolation, distended endoplasmic reticulum, and a marked increase in lipid droplets. Leydig cells exhibited a slight increase in lipid droplets, fewer mitochondria, and diminution and segregation of the agranular endoplasmic reticulum from mitochondria. A correlation between ultrastructural and biochemical changes in HFA-induced testicular atrophy is presented.
D000096:Acetone / Q000031:analogs & derivatives* / Q000633:toxicity; D000818:Animals; D005466:Fluorocarbons / Q000633:toxicity*; D007985:Leydig Cells / Q000648:ultrastructure; D050356:Lipid Metabolism; D008297:Male; D051381:Rats; D012708:Sertoli Cells / Q000648:ultrastructure; D013091:Spermatogenesis / Q000187:drug effects; D013733:Testicular Diseases / Q000139:chemically induced* / Q000473:pathology; D006845:Hydrocarbons, Fluorinated
D000096:Acetone; D005466:Fluorocarbons; C017366:hexafluoroacetone; D006845:Hydrocarbons, Fluorinated