[Stool behavior following the administration of antacids].
The direct correlation between the dosage of magnesium in antacids and the appearance of partly massive diarrheas in ulcus-patients known from literature could be confirmed. The clinically relevant dosage of antacids of 420 mval NK/day, divided in six individual dosages, resulted in diarrheas from the second to fourth day in 32 percent of the test persons when antacid A with a high content of magnesium was administered. There was no hint for a constipating effect of Solugastril gel at these high dosages (= 12 individual doses). Indeed the application of an Al-Ca-antacid may result in a slight fecal impaction, however, at the same time also to an increase of stool frequency, which is similar to that obtained with antacid B having a lower content of magnesium. The antacid can be regarded as neutral concerning stool frequency and consistency in the majority of test persons. From all four tested antacids the triple-combination (Al, Mg, Ca), showed the least important deviations from the preceding norms concerning stool frequency and consistency. The triple-combination shows an absolutely neutral stool behaviour. Serum electrolytes remained in the normal range with the Al-Ca- and the Al-Mg-Ca-antacid; whereas after application of antacid. A with high magnesium content, important increases of magnesium could be observed after seven days already, which were also dealt with in the literature.
D000536:Aluminum Hydroxide / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D002119:Calcium Carbonate / Q000494:pharmacology*; D003672:Defecation / Q000187:drug effects*; D004338:Drug Combinations; D005243:Feces / Q000032:analysis; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D008274:Magnesium / Q000097:blood / Q000494:pharmacology*; D008276:Magnesium Hydroxide / Q000494:pharmacology*; D008297:Male; D010710:Phosphates / Q000097:blood
D004338:Drug Combinations; D010710:Phosphates; D000536:Aluminum Hydroxide; D002119:Calcium Carbonate; D008274:Magnesium; D008276:Magnesium Hydroxide; D002118:Calcium
Stuhlverhalten nach Gabe von Antazida.