Imipramine inhibiton of ragweed allergic conjunctivitis.
Twenty-seven patients sensitive to ragweed pollen were treated with topical imipramine 0.05% in one eye and vehicle in the other in a double-masked fashion. The eyes treated with imipramine showed significantly less redness, tearing, and discomfort after exposure to pollen extract. Imipramine, a tricyclic antidepressant, appears to be an effective antihistamine in the eye.
D000287:Administration, Topical; D000328:Adult; D003231:Conjunctivitis / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006633:Histamine Antagonists / Q000008:administration & dosage*; D006801:Humans; D006967:Hypersensitivity / Q000517:prevention & control; D007099:Imipramine / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D010936:Plant Extracts; D011058:Pollen
D006633:Histamine Antagonists; D010936:Plant Extracts; D007099:Imipramine