title: Supplementation of milk with iron bound to lactoferrin using weanling mice. II: Effects on tissue manganese, zinc, and copper.
abstract: Iron supplementation is recommended for formula-fed infants, and it is currently suggested that iron be supplemented in formulas at a minimum of 6 mg/L. A negative side effect of iron supplementation, however, may be a reduction in the absorption of elements with similar physicochemical properties. We investigated this possibility by evaluating the impact of iron supplementation at 6 mg/L on tissue concentrations of zinc, copper, and manganese. Weanling mice fed a supplemented diet for 4 weeks had markedly lower tissue manganese concentrations than mice fed a nonsupplemented diet. Tissue zinc and copper levels were only marginally affected. The potential negative effect of iron supplementation on manganese status in the human infant should be evaluated.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002417:Cattle; D003300:Copper / Q000378:metabolism*; D005260:Female; D005527:Food, Fortified; D007501:Iron / Q000008:administration & dosage*; D007781:Lactoferrin / Q000008:administration & dosage*; D007782:Lactoglobulins / Q000008:administration & dosage*; D008345:Manganese / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D014886:Weaning; D015032:Zinc / Q000378:metabolism*
chemical_list: D007782:Lactoglobulins; D008345:Manganese; D003300:Copper; D007501:Iron; D007781:Lactoferrin; D015032:Zinc