Vitamin B12 levels in the prolonged use of sodium nitroprusside.
Long-term (greater than 48 h) sodium nitroprusside (SNP) infusion significantly reduced cobalamin (vitamin B12) levels in 23 patients treated in a CCU after myocardial infarction. There was no evidence of vitamin B12 deficiency or SNP toxicity. Low vitamin B12 levels should not limit the use of SNP, because prolonged infusion of SNP at maximum doses of 2.5 micrograms/kg X min did not adversely affect hemodynamic stability.
D001794:Blood Pressure / Q000187:drug effects; D003422:Critical Care; D003486:Cyanides / Q000506:poisoning; D004305:Dose-Response Relationship, Drug; D005292:Ferricyanides / Q000627:therapeutic use*; D006801:Humans; D007362:Intensive Care Units; D009203:Myocardial Infarction / Q000188:drug therapy*; D009599:Nitroprusside / Q000009:adverse effects / Q000627:therapeutic use*; D011669:Pulmonary Wedge Pressure / Q000187:drug effects; D011674:Pulse / Q000187:drug effects; D014805:Vitamin B 12 / Q000097:blood*
D003486:Cyanides; D005292:Ferricyanides; D009599:Nitroprusside; D014805:Vitamin B 12