One hundred percent patency of one-millimeter polytetrafluoroethylene (Gore-tex) grafts in the carotid arteries of rats.
Expanded polytetrafluoroethylene arterial interposition grafts with an internal diameter of 1.0 mm were placed in the carotid arteries of rats. At 2 weeks, 100% patency rate was achieved by the use of strict sterile technique in 23 rats. In contrast, only 1 out of 21 grafts remained open in rats operated using standard clean but nonsterile technique, 5% patency. All thrombosed grafts showed evidence of infection. Orally administered aspirin at therapeutic doses prolonged bleeding times in the rats but did not affect patency results in either group.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001760:Bleeding Time; D001792:Blood Platelets / Q000502:physiology; D001807:Blood Vessel Prosthesis; D002339:Carotid Arteries / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D006085:Graft Survival; D008297:Male; D008866:Microsurgery; D011138:Polytetrafluoroethylene; D011859:Radiography; D051381:Rats; D011919:Rats, Inbred Strains; D013927:Thrombosis / Q000209:etiology
D011138:Polytetrafluoroethylene; D001241:Aspirin