title: A pilot study of flutamide. A new agent in the treatment of advanced prostatic cancer.
abstract: Flutamide, a new non-steroidal antiandrogenic agent, was administered in the treatment of five assessable patients with advanced carcinoma of the prostate. Two patients showed significant clinical benefit, one showed a reduction in his requirement for analgesia and two failed to benefit; side-effects were minimal. These results indicate the need for a controlled clinical trial of flutamide in patients with prostatic cancer.
mesh_terms: D000813:Anilides / Q000627:therapeutic use*; D004341:Drug Evaluation; D005485:Flutamide / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010865:Pilot Projects; D011471:Prostatic Neoplasms / Q000188:drug therapy*
chemical_list: D000813:Anilides; D005485:Flutamide