[Intravenous infusions of fat emulsions containing medium and long-chain triglycerides have no effect on basal and secretin stimulated pancreatic secretion in man].
The effect of an intravenous infusion of a 10% fat solution containing 50 g/l medium chain triglycerides (MCT) and 50 g/l long chain triglycerides (LCT) on exocrine pancreatic secretion was studied in 18 healthy volunteers. Each subject was studied twice on separate days. In period I 0.9% NaCl was given intravenously on both days. In the following period II either a 10% solution of MCT-fat or 0.9% NaCl were given intravenously in a randomized order at a rate of 100 ml/h. Periods I and II lasted 150 minutes each. Throughout the experiment pancreatic secretion was stimulated by saline, 0.1 U/kg/h secretin, or 0.25 U/kg/h secretin in 6 subjects each. In period II, MCT/LCT infusions did not influence pancreatic outputs of volume, bicarbonate and enzymes when compared to the NaCl infusion in the control experiment irrespective of the type of stimulation. Therefore, intravenous infusions of MCT may be used in clinical situations where the pancreas should be kept at full rest.
D000328:Adult; D005217:Fat Emulsions, Intravenous; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D012633:Secretin / Q000378:metabolism*; D014280:Triglycerides / Q000008:administration & dosage / Q000494:pharmacology*
D005217:Fat Emulsions, Intravenous; D014280:Triglycerides; D012633:Secretin
Intravenöse Infusionen von Fettemulsionen mit mittel- und langkettigen Triglyzeriden (MCT/LCT) haben keine Auswirkungen auf die basale und die sekretinstimulierte Pankreassekretion beim Menschen.