title: Thyroid epididymal relationship. II. Influence of hyperthyroidism on epididymal lipids.
abstract: The influence of experimentally induced hyperthyroidism on the lipid composition of the caput and cauda epididymides has been studied in pubertal and adult rats. Thyroxine treatment did not alter the major lipid classes in the epididymis. However, regional and age-related fluctuations in the concentration of mono-, di- and triacylglycerols have been observed. While the diacylglycerols increase, mono- and triacylglycerols were found to decrease, suggesting an inverse relationship between these fractions. Among the phospholipid fractions, phosphatidylcholine and phosphatidylethanolamine were reduced. The changes in epididymal lipid profiles give an indication that the epididymis may be yet another site responsible for fertility disturbances in hyperthyroid males. The withdrawal of thyroxine from hyperthyroid animals returned the epididymal lipid profiles to normal levels. This indicates that the effects of thyroxine in the epididymis are temporary and reversible following thyroxine withdrawal.
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000378:metabolism; D004822:Epididymis / Q000378:metabolism / Q000503:physiopathology*; D005989:Glycerides / Q000378:metabolism; D006980:Hyperthyroidism / Q000503:physiopathology*; D050356:Lipid Metabolism; D008297:Male; D009928:Organ Specificity; D051381:Rats; D011919:Rats, Inbred Strains; D012741:Sexual Maturation; D013961:Thyroid Gland / Q000503:physiopathology*; D013974:Thyroxine
chemical_list: D005989:Glycerides; D002784:Cholesterol; D013974:Thyroxine