Male-restricted expression of H-Y antigen on preimplantation mouse embryos.
The H-Y (male) antigen is detectable on 50% of eight-cell mouse embryos. We show that 82% of the offspring resulting from the transfer of (C57BL/6 X A/J)F1 embryos surviving treatment with H-Y antibody and complement to the uteruses of pseudopregnant mice are female. The increased ratio of female-to-male births indicates that the H-Y-bearing embryos are male.
D000818:Animals; D001755:Blastocyst / Q000276:immunology*; D003165:Complement System Proteins; D004624:Embryo Transfer; D005260:Female; D006182:H-Y Antigen / Q000235:genetics* / Q000276:immunology; D007106:Immune Sera / Q000494:pharmacology; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D012733:Sex Differentiation
D006182:H-Y Antigen; D007106:Immune Sera; D003165:Complement System Proteins