Ability of L-triiodothyronine to modulate glucocorticoid-evoked brush border enzyme activities in cultured fetal rat intestine.
In vitro organ culture of developing fetal rat intestine emphasizes the absence of direct effect of thyroid hormone on several brush border enzymes in contrast with its ability to inhibit or enhance dexamethasone (DX) -evoked enzyme activities. Indeed, the presence of triiodothyronine in the culture medium leads mainly to a significant decrease of DX-stimulated lactase and to a further stimulation of DX-induced sucrase activities.
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D004386:Duodenum / Q000187:drug effects / Q000196:embryology / Q000201:enzymology*; D004848:Epithelium / Q000201:enzymology; D005260:Female; D007583:Jejunum / Q000187:drug effects / Q000196:embryology / Q000201:enzymology*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014284:Triiodothyronine / Q000494:pharmacology*
D014284:Triiodothyronine; D003907:Dexamethasone