[DNP complex of the spermatogenic cells of rats with hypovitaminosis A].
Retinol deficiency in rats was shown to cause atypical changes of DNP-complex in spermatogenic cells and a decrease in their fertility. The final stages of spermiogenesis were found to be the most sensitive: ca. 25% of testicular sperms were characterized by abnormal chromatin structure and deficiency in spermiospecific argininerich histones what might be related to a sharp decrease in arginine content in blood plasma. Similar results were obtained with rats kept on retinoic acid. Thus, retinoic acid fails to restore retinol-dependent processes involved in the formation of sperms with normal DNP-complex.
D000818:Animals; D002454:Cell Differentiation; D004247:DNA / Q000378:metabolism; D003852:Deoxyribonucleoproteins / Q000378:metabolism*; D004224:Diterpenes; D005298:Fertility; D006657:Histones / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D000084562:Retinyl Esters; D013091:Spermatogenesis; D013093:Spermatogonia / Q000166:cytology / Q000378:metabolism*; D013094:Spermatozoa / Q000378:metabolism*; D013997:Time Factors; D014212:Tretinoin / Q000008:administration & dosage / Q000031:analogs & derivatives; D014801:Vitamin A / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism; D014802:Vitamin A Deficiency / Q000378:metabolism*
D003852:Deoxyribonucleoproteins; D004224:Diterpenes; D006657:Histones; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate; D014212:Tretinoin; D004247:DNA; C026296:methyl retinoate
Sostoianie DNP-kompleksa spermatogennykh kletok krys pri gipovitaminoze A.