title: Necrotizing vasculitis from radiographic contrast media.
abstract: Two patients in whom cutaneous necrotizing vasculitis and nephritis developed 12 to 22 hours after the intravascular injection of radiocontrast media are presented. In one patient, the fortuitous observation was made of sparing of the skin from vasculitis in an area into which xylocaine and epinephrine had been injected 4 hours prior to administration of the radiocontrast material. The possible mechanisms by which these reactions may have taken place and the potential implications are discussed.
mesh_terms: D000368:Aged; D001706:Biopsy; D003287:Contrast Media / Q000009:adverse effects*; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009393:Nephritis / Q000139:chemically induced* / Q000276:immunology; D012867:Skin / Q000473:pathology; D013997:Time Factors; D018366:Vasculitis, Leukocytoclastic, Cutaneous / Q000139:chemically induced* / Q000276:immunology
chemical_list: D003287:Contrast Media