title: Dietary selenium levels needed to maintain balance in North American adults consuming self-selected diets.
abstract: Dietary selenium intake and selenium balance were measured during 4 1-wk metabolic periods over the course of 12 months in 27 free-living adult volunteers consuming self-selected diets. Men consumed more selenium in their diets than women (90 +/- 4 versus 74 +/- 3 micrograms/day), but plasma selenium levels were similar for both sexes (136 +/- 4 versus 133 +/- 4 ng/ml, respectively). Neither dietary selenium intake nor plasma selenium levels varied seasonally. Regression of selenium balance versus intake indicated that adult men needed 80 micrograms SE/day to stay in balance, whereas women needed only 57 micrograms SE/day. When balance and intake were adjusted for body weight, the sex difference disappeared, and both men and women needed about 1 microgram of dietary selenium per kg of body weight per day to maintain balance. The levels of dietary selenium reported here as necessary to maintain balance in North American adults are considerably higher than those previously reported as needed for balance in adult women from New Zealand, a country where low selenium status is common. Our results indicate that the levels of dietary selenium needed to achieve balance are a function of lean body mass and historical selenium intake.
mesh_terms: D000328:Adult; D001835:Body Weight; D005243:Feces / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008396:Maryland; D009751:Nutritional Requirements; D012621:Seasons; D012643:Selenium / Q000008:administration & dosage / Q000378:metabolism*; D012737:Sex Factors
chemical_list: D012643:Selenium