Erythroid precursors cultured from adult mice are sensitive to H2O2 toxicity.
The growth of late erythroid precursors (CFU-Es) from adult bone marrow is inhibited when Iscove 's modified Dulbecco's medium supplied in liquid form is used. Catalase and other H2O2 destroying compounds restore the capacity of culture medium to support colony development. However early precursors from adult bone marrow and fetal liver CFU-Es were resistant to H2O2.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D002374:Catalase / Q000378:metabolism; D002478:Cells, Cultured; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000502:physiology; D006861:Hydrogen Peroxide / Q000633:toxicity*; D007700:Kinetics; D051379:Mice; D008810:Mice, Inbred C57BL
D006861:Hydrogen Peroxide; D002374:Catalase