Neuroendocrine indices of depression in pseudocyesis. A case report.
Depressive illness has been associated with reversible abnormalities in the pituitary response of growth hormone, prolactin, and ACTH-cortisol. We saw similar neuroendocrine abnormalities in a patient with pseudocyesis. Normalization of the hormonal responses occurred with resolution of the pseudocyesis. Ovarian responsiveness to HCG suggests pseudocyesis to be of central hypothalamic-pituitary origin similar to polycystic ovarian disease, with neuroendocrine data consistent with reversible depression. In patients with affective illness, ovulatory disturbances may be the presenting symptom. Thorough psychosocial evaluation may be an important tool in the diagnosis of and therapy for anovulation.
D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D003863:Depression / Q000097:blood*; D005260:Female; D006728:Hormones / Q000097:blood; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism*; D011555:Pseudopregnancy / Q000097:blood*
D006063:Chorionic Gonadotropin; D006728:Hormones