The effects of lanthanum chloride administration in newborn chicks on glutamate uptake and release by brain synaptosomes.
Acute i.p. administration of lanthanum chloride to newborn chicks at a single dose of 250 mg/kg body weight causes inhibition of the high affinity uptake of [14C]glutamate by isolated brain synaptosomes. There is also a marked decrease in the release of preloaded [14C]glutamate from brain synaptosomes in the presence of externally available Ca2+ (1.2 mM) or a high K+ concentration (71 mM). The inhibition of glutamate release has been discussed in relation to depletion of Ca2+ binding to the synaptosomal membrane under lanthanum intoxication.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D002645:Chickens; D005971:Glutamates / Q000378:metabolism*; D007811:Lanthanum / Q000494:pharmacology*; D008297:Male; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
D005971:Glutamates; C028521:lanthanum chloride; D007811:Lanthanum; D002118:Calcium