Functional properties of the whole blood in a carrier of Hb-Atlanta: beta 75 (E-19) Leu-Pro.
The Authors illustrate the main functional parameters of the whole blood in a heterozygous carrier of the unstable Hb-Atlanta. The most important results are represented by a right-shifted P50, by a lowered value of n and by an almost normal pH-depending Bohr effect. It is very likely that the first report depends on the relative Hb-A deficiency, whereas the second one could be due to the presence of the unstable Hb. Moreover, the linkage between this latter and DPG would be present.
D001790:Blood Physiological Phenomena; D005260:Female; D006455:Hemoglobins, Abnormal / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D010108:Oxyhemoglobins / Q000378:metabolism
D006455:Hemoglobins, Abnormal; D010108:Oxyhemoglobins; C035046:hemoglobin Atlanta