[International clinico-pharmacokinetic study of individual predictions of the therapeutic effect of leponex (methodology and organization)].
Multicentre international studies make it possible to amass rapidly and reliably the necessary amount of representative data allowing for the verification of the results obtained by different scientific schools. They also represent the most effective approach to the search for attaining the mutual understanding among specialists of different scientific schools and for the elaboration of uniform clinical outlooks . Guidelines were developed to be adhered to while organizing and conducting multicentre psychopharmacological studies. The authors describe the general scheme and the basic stages of a multicentre psychopharmacological study of leponex which involved specialists from ten centres from six countries (CSSR, GDR, HPR, PRB , PPR, USSR).
D003024:Clozapine / Q000627:therapeutic use*; D003984:Dibenzazepines / Q000627:therapeutic use*; D004341:Drug Evaluation / Q000379:methods; D005061:Europe, Eastern; D006801:Humans; D007391:International Cooperation; D007700:Kinetics; D011379:Prognosis; D012559:Schizophrenia / Q000188:drug therapy*
D003984:Dibenzazepines; D003024:Clozapine
Mezhdunarodnoe kliniko-farmakokineticheskoe issledovanie individual'noĭ prediktsii terapevticheskogo éffekta leponeksa (metodologiia i organizatsiia).