title: Further evidence of the antiarrhythmic efficacy of taurine in the rat heart.
abstract: The potential antidysrrhythmic effect of taurine has been studied both "in vitro" and "in vivo". "In vitro experiments were performed on a model of automaticity induced in the isolated right ventricle of the rat. The "in vivo" studies have been done on anesthetized rats, assessing the effect of taurine on the electrical activity of the heart by continuous ECG records. Taurine decreases the "in vitro" automatic ventricular frequency. "In vivo" reduces heart rate (P-P interval increases) and conduction through the ventricular myocardium (prolongs QRS interval duration). We conclude that taurine possesses experimentally antidysrrhythmic activity "in vitro" and "in vivo", that would warrant further research.
mesh_terms: D000818:Animals; D000889:Anti-Arrhythmia Agents; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D007263:Infusions, Parenteral; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013654:Taurine / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D000889:Anti-Arrhythmia Agents; D013654:Taurine