Stability of corticosteroids under anaerobic conditions. VII. 17a-hydroxy-17a-hydroxymethyl-17-keto-D-homosteroid phosphate.
The major decomposition product of prednisolone phosphate formed under anaerobic decomposition conditions in aqueous solution at pH = 8.3 is identified as 17a-hydroxy-17a-hydroxymethyl-17-keto-D-homosteroid phosphate. The chromatographic properties, the isolation and the structure elucidation of both the D-homosteroid phosphate and its specific dephosphorylated analogue are given. Finally a mechanism leading to the D-homosteroid phosphate is postulated.
D000469:Alkaline Phosphatase / Q000032:analysis; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D002855:Chromatography, Thin Layer; D004355:Drug Stability; D013058:Mass Spectrometry / Q000379:methods; D010100:Oxygen; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000032:analysis; D013056:Spectrophotometry, Ultraviolet / Q000379:methods
C041109:17a-hydroxy-17a-hydroxymethyl-17-keto-homo-D-prednisolone phosphate; D011239:Prednisolone; D000469:Alkaline Phosphatase; D010100:Oxygen