Topical treatment of experimental herpes simplex keratouveitis with 2'-O-glycylacyclovir. A water-soluble ester of acyclovir.
2'-O-glycylacyclovir, a water-soluble ester derivative of acyclovir, has proved efficacious in the topical treatment of epithelial and stromal herpes simplex keratitis, and iritis therewith associated, when administered as a 1% eyedrop formulation to rabbits.
D000212:Acyclovir / Q000008:administration & dosage / Q000031:analogs & derivatives*; D000818:Animals; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D009883:Ophthalmic Solutions; D011817:Rabbits; D012995:Solubility; D014605:Uveitis / Q000188:drug therapy*
D009883:Ophthalmic Solutions; C040067:2'-O-glycyl acyclovir; D000212:Acyclovir