Lecithin-cholesterol acyltransferase activity in children in the early neonatal period.
Changes in the rate of plasma cholesterol esterification occurring shortly after birth were followed by determining the activity of lecithin-cholesterol acyltransferase (EC 2.3.1.43) in newborn children, and at the age of 3 days and 3 months. The radioassay method using 'common' substrate was applied. The molar esterification rate (MER) in umbilical cord serum was about half of the values found in the sera of 3-day-old and 3-month-old children, or adult subjects. Because of a positive correlation between MER and the plasma concentration of unesterified cholesterol, the values of fractional esterification rate in children were in good agreement with those characteristic for healthy adults.
D000328:Adult; D002784:Cholesterol / Q000097:blood; D002788:Cholesterol Esters / Q000097:blood; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D002788:Cholesterol Esters; D014280:Triglycerides; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase