The water proton spin-lattice relaxation time measurements in liver samples from hepatectomized and sham-operated rats.
We report the proton spin-lattice relaxation times (T1) of rat liver samples taken at different times after partial hepatectomy. The T1 values obtained are compared with those of liver samples from sham-operated rats and of liver samples from rats that had not undergone any surgical treatment. The results show that surgical stress significantly influences the T1 values of sham-operated rats both in their absolute value and in their dependence on the time after the operation, while it induces only a modest early increase of the water content. Possible effects of liver regeneration on 1H-T1 are almost completely concealed by the changes due to the surgical operation. These results emphasize the importance of the choice of a suitable control for T1 measurements in biological systems.
D000818:Animals; D001834:Body Water; D004247:DNA / Q000096:biosynthesis; D006498:Hepatectomy; D008115:Liver Regeneration; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000503:physiopathology; D013997:Time Factors
D004247:DNA