title: Effect of glucagon on ureteric peristalsis in man, pig, rabbit and rat.
abstract: The effect of glucagon on ureteric peristalsis in man, pig, rabbit and rat has been studied using specially shaped perspex blocks containing silver/silver chloride bipolar electrodes. In all subjects the ureteric electrical activity was recorded during laparotomy. Glucagon was administered as a single intravenous dose of 14 micrograms per kilogram in man and in doses of between 6.25 and 160 micrograms per kilogram in the other species. The mean (+/- S.E.M.) peristaltic rates per minute were: man 4.85 (+/- 0.66), pig 2.04 (+/- 0.36), rabbit 3.78 (+/- 0.23) and rat 5.02 (+/- 0.16). Glucagon was found to have no significant effect on ureteric peristalsis in man, rabbit or rat, whilst in the pig a variable effect was seen.
mesh_terms: D000200:Action Potentials; D000818:Animals; D004594:Electrophysiology; D005260:Female; D005934:Glucagon / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D013552:Swine; D014513:Ureter / Q000187:drug effects / Q000502:physiology*
chemical_list: D005934:Glucagon