title: Heterocyclic antidepressants in nonpsychiatric disorders.
abstract: Heterocyclic antidepressants have been used successfully in the treatment of migraine, enuresis and encopresis, peptic ulcer disease, irritable bowel syndrome, chronic pain, narcolepsy, sleep apnea and attention deficit disorder. The mechanism of their therapeutic effects in these conditions is still unclear. Serotonergic, noradrenergic, anticholinergic and antihistaminic properties and rapid-eye-movement sleep suppression have been implicated.
mesh_terms: D000928:Antidepressive Agents / Q000627:therapeutic use*; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use; D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy; D003109:Colonic Diseases, Functional / Q000188:drug therapy; D004688:Encopresis / Q000188:drug therapy; D004775:Enuresis / Q000188:drug therapy; D006801:Humans; D008881:Migraine Disorders / Q000188:drug therapy; D009290:Narcolepsy / Q000188:drug therapy; D010146:Pain / Q000188:drug therapy; D010437:Peptic Ulcer / Q000188:drug therapy; D012891:Sleep Apnea Syndromes / Q000188:drug therapy
chemical_list: D000928:Antidepressive Agents; D000929:Antidepressive Agents, Tricyclic