[Peptide mapping of membrane-bound monooxygenases].
A method is developed for studies of differences in peptide structure of native membrane-bound monooxygenases using limited proteolysis of liver microsomal hemoproteins. Analysis of peptide maps was carried out in constitutive and induced by 3 methylcholanthrene and 2, 3, 7, 8-tetrachlorodibenzodioxin enzyme forms, responsible for metabolic and biological activation of polycyclic aromatic hydrocarbons.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D004790:Enzyme Induction / Q000187:drug effects; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000096:biosynthesis; D010446:Peptide Fragments / Q000032:analysis; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology; D011083:Polycyclic Compounds / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D010446:Peptide Fragments; D000072317:Polychlorinated Dibenzodioxins; D011083:Polycyclic Compounds; D008748:Methylcholanthrene; D006899:Mixed Function Oxygenases
Peptidnoe kartirovanie membranosviazannykh monooksigenaz.