title: What is the incidence of holoprosencephaly?
abstract: The incidence of holoprosencephaly with normal chromosomes has been estimated at between 1 in 16 000 and 1 in 53 394 live births. It has been found that during a 3-year period in the Bristol and Weston Health District there were six cases of holoprosencephaly, two of which were familial, and these cases are described. This represents an incidence of 1 in 5200 and during the preceding 3-year period the incidence in the same area was 1 in 14 520 births.
mesh_terms: D000015:Abnormalities, Multiple / Q000453:epidemiology* / Q000235:genetics; D002552:Cerebral Ventricles / Q000002:abnormalities*; D002971:Cleft Lip / Q000453:epidemiology* / Q000235:genetics; D004739:England; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D008831:Microcephaly / Q000453:epidemiology* / Q000235:genetics; D013577:Syndrome