Effects of oral contraceptives, or lanosterol, on ADP-induced aggregation and binding of 125I-fibrinogen to rat platelets.
The aggregation to ADP and the binding of 125I-fibrinogen to platelets from rats treated with oral contraceptives or normal platelets treated in vitro with lanosterol were compared to their respective controls. Both types of platelets showed a significant increase in ADP-induced aggregation and in binding of fibrinogen, indicating that the effect of oral contraceptives could be partly due to increased levels of lanosterol in platelet membrane.
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D003276:Contraceptives, Oral / Q000494:pharmacology*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism*; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D007810:Lanosterol / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats
D003276:Contraceptives, Oral; D007457:Iodine Radioisotopes; D007810:Lanosterol; D000244:Adenosine Diphosphate; D005340:Fibrinogen