Effect of heme on the activity of chick embryo liver mitochondrial delta-aminolevulinate synthase.
We have examined the effect of heme on the activity of native delta-aminolevulinate synthase isolated from drug-induced chick embryo liver mitochondria. The enzyme was not inhibited by concentrations of heme up to 1 mM and this finding makes it improbable that heme acts physiologically to control mitochondrial delta-aminolevulinate synthase activity.
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism*; D000818:Animals; D002642:Chick Embryo; D004789:Enzyme Activation; D006418:Heme / Q000494:pharmacology*; D008278:Magnesium Sulfate / Q000494:pharmacology; D008930:Mitochondria, Liver / Q000201:enzymology*; D012965:Sodium Chloride / Q000494:pharmacology
D006418:Heme; D012965:Sodium Chloride; D008278:Magnesium Sulfate; D000624:5-Aminolevulinate Synthetase