Radiosensitization of human bronchogenic carcinoma cells by interferon beta.
The effects of interferons on the radiosensitivity of in vitro human bronchogenic carcinoma cells was investigated. Human fibroblast-derived interferon (IFN-beta) was found to sensitize cells to gamma irradiation while either HuIFN-alpha or mouse IFN-alpha/beta did not. The observed radiosensitization was supra-additive and resulted in a decrease in the shoulder width of the radiation dose-cell survival curve but did not affect the slope. The degree of radiosensitization of the various IFNs tested paralleled the antiproliferative effects of these IFNs on this cell line.
D000818:Animals; D002283:Carcinoma, Bronchogenic / Q000532:radiotherapy / Q000628:therapy*; D002470:Cell Survival / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D007370:Interferon Type I / Q000627:therapeutic use*; D051379:Mice; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*
D007370:Interferon Type I; D011838:Radiation-Sensitizing Agents