An attempt to isolate and identify allergens in lanolin.
One sensitizer, a sterol, has previously been reported to be present in lanolin. In this study, a related substance, a sterol, with a molecular weight of 424 has been isolated. A few sensitive subjects did not react to this substance. Lanolin probably contains several sensitizers. Sensitization to lanolin in guinea pigs seems previously to have failed. In this study, a methanol extract of a lanolin preparation containing large amounts of sterols sensitized guinea pigs.
D000485:Allergens / Q000302:isolation & purification*; D000818:Animals; D005591:Chemical Fractionation; D006168:Guinea Pigs; D006801:Humans; D007809:Lanolin / Q000032:analysis*; D010328:Patch Tests; D013261:Sterols / Q000302:isolation & purification*
D000485:Allergens; D013261:Sterols; D007809:Lanolin