title: Intestinal motility after infusion of arachis oil into duodenum and ileum of dogs.
abstract: Arachis oil and a mixture of arachis oil with bile and pancreatic enzymes were infused into the duodenum and ileum of dogs via surgically positioned catheters in order to study the mechanism of disruption of the migrating complex by intraluminally infused triglycerides, the importance of cholecystokinin and neurotensin in this event, and the pattern of digestive myoelectrical activity during fat digestion. When infused into the duodenum both arachis oil and the oil-bile-pancreatic enzyme mixture disrupted the migrating myoelectric complex (MMC). When infused into the ileum, only the oil-bile-pancreatic enzyme mixture disrupted the MMC. The duration of the disruption lasted as long as when the same amount of oil was administered orally. Triglyceride-induced digestive activity was characterized by the frequent alternation of short periods of spiking activity and short periods of quiescence. It is concluded that the triglyceride-induced disruption of the MMC-pattern is not caused by the triglyceride itself but by some emulsion or digestion product. We further suggest that the disruption is hormonally mediated and due to fat-stimulated neurotensin, rather than cholecystokinin (CCK), release.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001646:Bile; D002766:Cholecystokinin / Q000502:physiology; D004063:Digestion / Q000187:drug effects; D004285:Dogs; D004386:Duodenum / Q000187:drug effects*; D004576:Electromyography; D005223:Fats / Q000378:metabolism; D005769:Gastrointestinal Motility / Q000187:drug effects*; D007082:Ileum / Q000187:drug effects*; D007263:Infusions, Parenteral; D007583:Jejunum / Q000187:drug effects; D009496:Neurotensin / Q000502:physiology; D009821:Oils / Q000008:administration & dosage* / Q000494:pharmacology; D010179:Pancreas / Q000201:enzymology; D000074241:Peanut Oil; D010938:Plant Oils
chemical_list: D005223:Fats; D009821:Oils; D000074241:Peanut Oil; D010938:Plant Oils; D009496:Neurotensin; D002766:Cholecystokinin