title: [Glucocorticoid hormones and the immune response].
abstract: The level of glyco- and mineralcorticoids in the blood and correlations between functional activity of hypothalamo-hypophyseal--adrenocortical system and antibody production, were investigated. The role of glycocorticoids in the immune system responses to antigen on the cellular and molecular levels including the changes in glycocorticoid binding sites and cyclo-nucleotides level, was shown. The role of glycocorticoids in actualization of the immune responses depending on the intensity and duration of hormonal changes, is considered from the standpoint of different sensitivity of the individual clones of immunocompetent cells to hormones.
mesh_terms: D000302:Adrenal Cortex / Q000276:immunology; D000818:Animals; D000917:Antibody Formation; D000937:Antigen-Antibody Reactions; D000941:Antigens / Q000276:immunology; D005938:Glucocorticoids / Q000276:immunology*; D007030:Hypothalamo-Hypophyseal System / Q000276:immunology; D007114:Immunization; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008901:Mineralocorticoids / Q000276:immunology; D009712:Nucleotides, Cyclic / Q000276:immunology; D011817:Rabbits; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000276:immunology; D013997:Time Factors
chemical_list: D000941:Antigens; D005938:Glucocorticoids; D008901:Mineralocorticoids; D009712:Nucleotides, Cyclic; D011965:Receptors, Glucocorticoid
vernacular_title: Gliukokortikoidnye gormony i immunnyĭ otvet.