title: Production of fumigaclavine A by Aspergillus tamarii Kita.
abstract: Aspergillus tamarii Kita. isolated from seeds of Paspalum scrobiculatum L. is found to produce ergot alkaloids in submerged culture. The culture filtrate and mycelium are observed to contain 0.125 mg/mL and 1.2 mg/g (dry weight) total alkaloids consisting of 86.5 and 91.3% fumigaclavine A, respectively. The identification of the compound was confirmed by high-performance liquid chromatography, ultraviolet, infrared, and mass spectrophotometry analyses. This is the first report of the production of ergot alkaloid by this fungus. The possible role of fumigaclavine A as a mycotoxin is discussed.
mesh_terms: D001230:Aspergillus / Q000032:analysis / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D004873:Ergolines / Q000032:analysis* / Q000096:biosynthesis / Q000302:isolation & purification; D004876:Ergot Alkaloids / Q000096:biosynthesis* / Q000302:isolation & purification; D013058:Mass Spectrometry; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D004873:Ergolines; D004876:Ergot Alkaloids; C010453:isofumigaclavine A