Effects of polyamines on platelet aggregation.
Polyamines, spermine and spermidine in the micromolar range (1-100 mumol/l) increase ADP and epinephrine-induced platelet aggregation in vitro. The possible rôle of polyamines as regulating factors of platelet aggregation in physiological and pathological states is discussed.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000293:Adolescent; D000328:Adult; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D013095:Spermidine / Q000494:pharmacology*; D013096:Spermine / Q000494:pharmacology*; D013268:Stimulation, Chemical
D013096:Spermine; D000244:Adenosine Diphosphate; D013095:Spermidine; D004837:Epinephrine