title: Effect of using an incorrect elimination rate constant in application of the Wagner-Nelson method to theophylline data in cases of zero order absorption.
abstract: Some authors have used an elimination rate constant derived from one theophylline treatment (e.g. the elixir) to apply the Wagner--Nelson method to concentration--time data from another treatment (e.g. a sustained-release form). Since there is considerable intrasubject variation in the elimination rate constant of theophylline such a practice usually involves use of an incorrect rate constant. By means of theoretical treatment and simulations the effects of such a practice are shown and illustrated.
mesh_terms: D000042:Absorption; D003692:Delayed-Action Preparations; D006801:Humans; D007700:Kinetics; D013806:Theophylline / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D003692:Delayed-Action Preparations; D013806:Theophylline