The prevention of cardiac arrhythmias produced in an animal model by the topical application of a phenol preparation in common use for face peeling.
We have shown in an animal model that complex ventricular arrhythmias produced by topical application of a phenol preparation that is used in face peeling can be prevented by a brisk diuresis at the time of application or by gradual application of the phenol preparation. We recommend that continuous cardiac monitoring and recording be performed in patients having topical phenol applications in order to determine the true incidence of cardiac arrhythmias and to ascertain if they are prevented by a forced diuresis, by the gradual application of the preparation, or by a combination of both.
D000287:Administration, Topical; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000503:physiopathology / Q000517:prevention & control*; D002615:Chemexfoliation / Q000009:adverse effects / Q000379:methods*; D004195:Disease Models, Animal; D004231:Diuresis / Q000187:drug effects*; D004562:Electrocardiography; D008297:Male; D008722:Methods; D010636:Phenols / Q000008:administration & dosage* / Q000009:adverse effects; D011817:Rabbits; D013997:Time Factors
D010636:Phenols