Normal and abnormal prolactin levels during human pregnancy. Lack of influence on fetoplacental endocrine function.
Serial measurements of serum prolactin (PRL), chorionic gonadotropin (hCG), estradiol and progesterone were performed during 16 normal pregnancies. The same hormone analyses were performed in a woman with the galactorrhea-amenorrhea syndrome and a pituitary adenoma during two pregnancies, with and without continued treatment with bromocriptine throughout gestation. The study indicates that marked differences in circulating PRL levels do not influence the fetoplacental hormone levels. Furthermore, tumor expansion may possibly be prevented and successful breast-feeding can be achieved after treatment with bromocriptine throughout gestation.
D000236:Adenoma / Q000097:blood / Q000188:drug therapy; D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000097:blood; D001971:Bromocriptine / Q000627:therapeutic use; D006063:Chorionic Gonadotropin / Q000097:blood; D004958:Estradiol / Q000097:blood; D005260:Female; D005687:Galactorrhea / Q000097:blood; D006801:Humans; D008431:Maternal-Fetal Exchange; D010911:Pituitary Neoplasms / Q000097:blood / Q000188:drug therapy; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood*
D006063:Chorionic Gonadotropin; D001971:Bromocriptine; D011374:Progesterone; D004958:Estradiol; D011388:Prolactin