Phagocytosis of aged erythrocyte membranes with a high fat content by the isolated perfused rat liver.
Erythrocyte membranes of a patient with excessively high serum fat levels were suspended in a perfusion medium free of immune globulines , protein, and hemoglobine , and then offered for phagocytosis in isolated perfused rat livers. The membrane changes, caused by hyperlipemia, led to a reduced rate of phagocytosis for young and old red cell membranes.
D000818:Animals; D004905:Erythrocyte Aging; D004910:Erythrocyte Membrane; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood*; D007728:Kupffer Cells / Q000502:physiology; D008099:Liver / Q000502:physiology*; D008111:Liver Function Tests; D008875:Middle Aged; D010477:Perfusion; D010587:Phagocytosis; D051381:Rats; D011919:Rats, Inbred Strains