Adrenal adenoma with 18-hydroxycorticosterone excess and hypertension: a variant of aldosteronomas.
A 46-year-old woman with hypertension, normokalemia, suppressed renin, normal catecholamines, and a left adrenal mass on the CT scan was found to have excessive 18-hydroxycorticosterone (18-OHB) and normal aldosterone levels in plasma, both of which responded poorly to sodium restriction and angiotension II, and supranormally to ACTH. Plasma 18-hydroxydeoxycorticosterone (18-OHDOC) was normal. After adrenalectomy, amelioration from hypertension occurred with a reduction in plasma 18-OHB and aldosterone. The plasma 18-OHDOC remained normal. The adrenal tumor was histologically an adenoma, containing a large amount of 18-OHB and a small amount of aldosterone. Thus, the present adenoma seems to be a variant of aldosteronomas.
D015069:18-Hydroxycorticosterone / Q000097:blood*; D000236:Adenoma / Q000097:blood* / Q000150:complications / Q000473:pathology; D000310:Adrenal Gland Neoplasms / Q000097:blood* / Q000150:complications / Q000473:pathology; D000450:Aldosterone / Q000097:blood*; D003345:Corticosterone / Q000031:analogs & derivatives*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000209:etiology* / Q000473:pathology; D008875:Middle Aged
D000450:Aldosterone; D015069:18-Hydroxycorticosterone; D003345:Corticosterone