Protocols based on steroid receptors: Great Britain.
Steroid receptors appear to have prognostic significance in operable and disseminated breast cancer, but not in primary locally advanced disease. Information on receptor status gives some indication of the pattern of metastatic disease. Absence of ER and PgR detect effectively patients who will not benefit from endocrine therapy and the presence of both receptors indicates the patients most likely to respond. Patients wih ER+ PgR- or ER- PgR+ tumours have an intermediate frequency of response to endocrine treatment. Receptor status is not a determinant of response to cytotoxic treatment.
D001943:Breast Neoplasms / Q000188:drug therapy / Q000628:therapy*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008408:Mastectomy; D011379:Prognosis; D011987:Receptors, Steroid / Q000032:analysis*; D013629:Tamoxifen / Q000627:therapeutic use*; D006113:United Kingdom
D011987:Receptors, Steroid; D013629:Tamoxifen