Effects of 17 beta-estradiol on a permanent line of rat endometrial cells grown in vitro and in vivo.
A permanent line of epithelioid cells derived from a primary culture of rat endometrium by spontaneous transformation in vitro was studied as a model for the actions of estrogen on target cells. The cells contained typical cytosol and nuclear estrogen receptors. Estradiol added in vitro increased the accumulation of cells as much as 60% over controls. Cells injected into ovariectomized athymic mice grew into solid tumors whose incidence was increased by treatment of the animals with estradiol.
D000818:Animals; D002369:Castration; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002478:Cells, Cultured; D003600:Cytosol / Q000187:drug effects; D004717:Endometrium / Q000166:cytology / Q000187:drug effects*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000209:etiology / Q000473:pathology; D010053:Ovary / Q000502:physiology; D051381:Rats; D011960:Receptors, Estrogen / Q000187:drug effects; D013737:Testis / Q000502:physiology
D011960:Receptors, Estrogen; D004958:Estradiol