Salivary gland accumulation of meta-[131I]iodobenzylguanidine.
Intense uptake of m-[131I] iodobenzylguanidine (I-131 MIBG ) has been observed in the salivary glands of patients undergoing scintigraphy for the location of suspected pheochromocytomas. This uptake of radioactivity was not due to free I-131 derived from the I-131 MIBG but rather to uptake of I-131 MIBG by sympathetic neuronal elements in the salivary glands. In keeping with this, administration of tricyclic antidepressants reversibly blocked salivary uptake of I-131 MIBG . Furthermore, I-131 MIBG uptake was markedly diminished by the ipsilateral salivary glands in a patient with Horner's syndrome, and was bilaterally diminished in a patient with severe idiopathic sympathetic autonomic neuropathy. The salivary gland uptake of I-131 MIBG may provide a means for the study of sympathetic innervation of these organs, and thus for the study of generalized disorders of autonomic innervation.
D019797:3-Iodobenzylguanidine; D000293:Adolescent; D000310:Adrenal Gland Neoplasms / Q000000981:diagnostic imaging; D000328:Adult; D000368:Aged; D000818:Animals; D002648:Child; D004285:Dogs; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000378:metabolism; D007462:Iodobenzenes / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000000981:diagnostic imaging; D011193:Potassium Iodide / Q000494:pharmacology; D011877:Radionuclide Imaging; D012463:Saliva / Q000378:metabolism; D012469:Salivary Glands / Q000000981:diagnostic imaging* / Q000294:innervation / Q000378:metabolism; D013270:Stomach / Q000000981:diagnostic imaging; D013564:Sympathetic Nervous System / Q000000981:diagnostic imaging; D013961:Thyroid Gland / Q000000981:diagnostic imaging
D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D011193:Potassium Iodide; D019797:3-Iodobenzylguanidine