[Characteristics of aniline, lead nitrate, carbon tetrachloride and formaldehyde as modifiers of chemical carcinogenesis].
The modifying effect of aniline, lead nitrate, carbon tetrachloride and formaldehyde on nitrosodimethylamine-induced blastogenesis was studied in chronic experiments on 750 CBA X C57 / Bl6 female mice. A mixture of carcinogen with aniline or formaldehyde given in drinking water for 39 weeks produced a significantly higher tumor incidence. A similar, though statistically insignificant, effect was registered for a mixture of carcinogen and lead citrate or carbon tetrachloride. It is emphasized that aniline and formaldehyde are capable of modifying effect at levels 10 times maximum allowable concentrations.
D000814:Aniline Compounds / Q000633:toxicity*; D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D004128:Dimethylnitrosamine; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D005557:Formaldehyde / Q000633:toxicity*; D007854:Lead / Q000633:toxicity*; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009566:Nitrates / Q000633:toxicity*; D013997:Time Factors
D000814:Aniline Compounds; D009566:Nitrates; D005557:Formaldehyde; D007854:Lead; C017461:lead nitrate; D002251:Carbon Tetrachloride; D004128:Dimethylnitrosamine; C023650:aniline
K kharakteristike anilina, nitrata svintsa, chetyrekhkhloristogo ugleroda i formal'degida kak modifikatorov khimicheskogo blastomogeneza.