Relationships between the electrostatic potential, epoxide hydrase inhibition and carcinogenicity for some hydrocarbon and halogenated hydrocarbon epoxides.
For a group of nine hydrocarbon and halogenated hydrocarbon epoxides, there is shown to be a good correlation between their abilities to inhibit epoxide hydrase and the quantity Vmin /Es, where Vmin is the most negative value of the molecule's electrostatic potential in the neighborhood of the epoxide oxygen and Es is a factor that takes account of steric effects. It is also demonstrated that carcinogenicity, for thirteen epoxides, appears to be associated with Vmin having a relatively large negative value. On this basis, several other epoxides are predicted to be carcinogenic. The electrostatic potentials used in developing these relationships have been computed by an ab initio self-consistent-field molecular orbital procedure, using optimized molecular geometries.
D000818:Animals; D002273:Carcinogens; D004563:Electrochemistry; D004851:Epoxide Hydrolases / Q000037:antagonists & inhibitors*; D004852:Epoxy Compounds / Q000633:toxicity*; D004988:Ethers, Cyclic / Q000633:toxicity*; D006838:Hydrocarbons / Q000633:toxicity*; D006846:Hydrocarbons, Halogenated / Q000633:toxicity*; D007700:Kinetics; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
D002273:Carcinogens; D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D006838:Hydrocarbons; D006846:Hydrocarbons, Halogenated; D004851:Epoxide Hydrolases