Effect of age on peptide chain initiation and elongation in preparations from brain, liver, kidney and skeletal muscle of the C57B1/6J mouse.
The effects of age on the initiation and elongation stages of protein synthesis were measured in cell-free preparations from brain, liver, kidney and skeletal muscle of young (3-5 months) and senescent (23-27 months) female C57B1/6J mice. The ability to form initiation complexes from isolated 40 S and 60 S ribosomal subunits decreased only slightly with age. In contrast, the rate of peptide chain elongation decreased by 67% in brain preparations, 80% in liver, 81% in kidney and 85% in skeletal muscle of the senescent mice when compared with the young mice.
D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism*; D005260:Female; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D046911:Macromolecular Substances; D051379:Mice; D008810:Mice, Inbred C57BL; D009132:Muscles / Q000378:metabolism*; D010441:Peptide Chain Elongation, Translational; D010442:Peptide Chain Initiation, Translational; D012269:Ribosomal Proteins / Q000096:biosynthesis
D046911:Macromolecular Substances; D012269:Ribosomal Proteins