title: [Characteristics of the fatal outcome of drug-induced anaphylactic shock].
abstract: Among 520 cases of drug anaphylactic shock there were 48 (9.2%) fatal outcomes. Analysis of the pathomorphological changes in shock showed them to have characteristic features consisting in blood redistribution (decentralization), its deposition in parenchymatous organs with marked disorders in microcirculation and diapedetic hemorrhages in serous, mucous membranes, and tissue of nearly all the organs, as well as signs of stasis and leukocyte aggregation, perivascular and pericellular edema and swelling of cells of different organs. In a protracted course of shock, marked degenerative changes of parenchymatous organs were observed. In the acute course and rapid fatal outcome pathomorphological changes were less marked than in a protracted and recurrent course which was characterized by the development of secondary pathological changes such as inflammatory, degenerative, and necrotic processes.
mesh_terms: D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced / Q000401:mortality / Q000473:pathology*; D003643:Death; D004177:Dipyrone / Q000009:adverse effects; D006801:Humans; D008297:Male; D010406:Penicillins / Q000009:adverse effects; D011343:Procaine / Q000009:adverse effects; D012008:Recurrence; D013307:Streptomycin / Q000009:adverse effects; D013997:Time Factors; D014586:USSR
chemical_list: D010406:Penicillins; D011343:Procaine; D004177:Dipyrone; D013307:Streptomycin
vernacular_title: Kharakteristika letal'nykh iskhodov ot lekarstvennogo anafilakti-cheskogo shoka.