Quantity and translation efficiency of liver microsomes in young and old rats following partial hepatectomy.
1. Liver microsomal quantity decreased in young rats 2 days after partial hepatectomy or sham operation, increased to preoperative values by 8 days, and remained unchanged 16 days following surgery. 2. In old rats, microsomal quantity remained unchanged following surgery, but increased in sham-operated controls. 3. Translational efficiency of microsomes from young, sham-operated animals was unaffected, but decreased 2 days after partial hepatectomy. 4. In old, sham-operated controls, efficiency decreased, but remained unchanged 2 days after partial hepatectomy. 5. Eight and 16 days after surgery, efficiency of microsomes from young and old animals appeared indistinguishable, and were similar to those of adults before surgery.
D000375:Aging; D000818:Animals; D004926:Escherichia coli / Q000235:genetics; D007700:Kinetics; D008099:Liver / Q000254:growth & development*; D008115:Liver Regeneration; D008862:Microsomes, Liver / Q000378:metabolism*; D014176:Protein Biosynthesis; D012343:RNA, Transfer / Q000235:genetics; D051381:Rats
D012343:RNA, Transfer