[RNA-polymerase activity of pathogenic and nonpathogenic influenza A virus variants].
The transcriptase activity of original mouse-apathogenic strains of human (A/USSR/05/81) and animal (A/walrus/Massachusetts/1/80) influenza viruses and their pathogenic variants was studied. Also RNA-polymerase was studied in two types of antigenic recombinants produced by hybridization of the parental strains one of which (A/PR8/34) was pathogenic for mice. The nonpathogenic viruses under study were shown to have a low transcriptase activity, while pathogenic variants of these strains had a higher RNA-polymerase activity (1 1/2-3 times higher than in the original virus). All the recombinants tested, irrespective of their pathogenicity, had approximately similar transcriptase activity, 1 1/2-2 times higher than the enzymatic activity of the parental nonpathogenic virus.
D000818:Animals; D000956:Antigens, Viral / Q000235:genetics; D012321:DNA-Directed RNA Polymerases / Q000032:analysis / Q000378:metabolism*; D005814:Genes, Viral; D014644:Genetic Variation; D009980:Influenza A virus / Q000201:enzymology* / Q000235:genetics / Q000472:pathogenicity; D007700:Kinetics; D051379:Mice; D011995:Recombination, Genetic
D000956:Antigens, Viral; D012321:DNA-Directed RNA Polymerases
Aktivnost' RNK-polimerazy patogennykh i nepatogennykh variantov virusov grippa A.