Objective response in amyloidosis treated with intermittent chemotherapy.
A 37-year-old woman with amyloidosis derived from light chain immunoglobulin had hepatosplenomegaly, elevated serum alkaline phosphatase values, and progressively destructive bony lesions. A 44-month intermittent course of chemotherapy with melphalan and prednisone resulted in regression, confirming the occasional efficacy of cytotoxic chemotherapy in this disease.
D000328:Adult; D000686:Amyloidosis / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008107:Liver Diseases / Q000188:drug therapy*; D008558:Melphalan / Q000008:administration & dosage* / Q000627:therapeutic use; D011241:Prednisone / Q000008:administration & dosage* / Q000627:therapeutic use; D013158:Splenic Diseases / Q000188:drug therapy*
D008558:Melphalan; D011241:Prednisone