title: [Effect of pathologic changes in the urinary epithelium on the absorption of ethoglucide (Epodyl) from the bladder].
abstract: Studies on the absorption of Ethoglucid from human urinary bladder, utilizing a photometric method to determine Ethoglucid in biological fluids, gave the following results: The intact uroepithelium prevents absorption of interluminal Ethoglucid as well as no significant increase of absorption was seen in the presence of superficial, highly differentiated cancers or inflammatory alterations of the bladder. Urothelial lesions after transurethral resection or infiltrating cancers permit an intercellular diffusion of Ethoglucid from the bladder cavity into the systemic circulation, due to a loss of intercellular gaps between the urothelial elements.
mesh_terms: D000042:Absorption; D004848:Epithelium / Q000378:metabolism; D004987:Ethers / Q000627:therapeutic use*; D005009:Ethoglucid / Q000097:blood / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D001743:Urinary Bladder / Q000378:metabolism*; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy
chemical_list: D004987:Ethers; D005009:Ethoglucid
vernacular_title: Einfluss pathologischer Urothelveränderungen auf die Resorption von Ethoglucid (Epodyl) aus der Harnblase.