[Effect of PSK on the recovery of macrophage function in tumor-bearing mice].
Chemotactic response of macrophage to PHA was depressed at early stages in allogeneic sarcoma 180-bearing ICR mice and syngeneic X5563-bearing C3H/He mice and their depressed response were restored to the normal levels by PSK. Macrophages-dependent resistance against Listeria monocytogenes at early phase of infection was depressed at the early stage after tumor inoculation. The depressed resistance was restored by PSK in X5563-bearing mice and by a combination of tumor resection and PSK in sarcoma 180-bearing mice.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002464:Cell Migration Inhibition; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D005260:Female; D008088:Listeriosis / Q000276:immunology; D008264:Macrophages / Q000187:drug effects / Q000276:immunology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008813:Mice, Inbred ICR; D011509:Proteoglycans / Q000494:pharmacology*; D012513:Sarcoma, Experimental / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology
D000903:Antibiotics, Antineoplastic; D011509:Proteoglycans; C010770:polysaccharide-K