(Acylaryloxy)acetic acid diuretics. 5. [(2-Alkyl- and 2,2-disubstituted-1,3-dioxo-5-indanyl)oxy]acetic acids.
Investigation of the chemistry of the potent uricosuric diuretic indacrinone (MK-196) prompted the synthesis of a series of 3-oxo derivatives, i.e., the indan-1,3-diones. In general, both pharmacological parameters (uricosuria and diuresis) were significantly less pronounced with the 1,3-diones than with the parent 1-oxo compounds.
D000284:Administration, Oral; D000818:Animals; D004232:Diuretics / Q000008:administration & dosage / Q000138:chemical synthesis*; D004285:Dogs; D005665:Furosemide / Q000494:pharmacology; D006016:Glycolates / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D007189:Indans / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000494:pharmacology; D007192:Indenes / Q000138:chemical synthesis*; D007275:Injections, Intravenous; D008297:Male; D002679:Pan troglodytes; D051381:Rats; D013329:Structure-Activity Relationship; D014528:Uricosuric Agents / Q000008:administration & dosage / Q000138:chemical synthesis*
D004232:Diuretics; D006016:Glycolates; D007189:Indans; D007192:Indenes; D014528:Uricosuric Agents; D005665:Furosemide; C013352:indacrinone