title: Chemotactic factor-specific desensitization of skin to infiltration by polymorphonuclear leukocytes.
abstract: The accumulation of polymorphonuclear leukocytes (PMNs) was measured in rabbits following single or repeated injections into skin sites of the inflammatory agents, zymosan-activated plasma and formylmethionyl-leucyl-phenylalanine. Fewer cells entered lesions restimulated with the same agent during the subsequent inflammatory response than simultaneously entered skin sites stimulated for the first time. Decreased reactivity of a restimulated site was specific to the initiating stimulus, developed within 2 to 4 h of initial stimulation and persisted for at least 8 h. The results indicate that PMN accumulation in acute inflammatory lesions is regulated locally by a chemotactic factor-specific mechanism which differs from PMN deactivation and concentration gradient mechanisms currently thought to regulate PMN migration in vivo.
mesh_terms: D000818:Animals; D002465:Cell Movement; D002630:Chemotactic Factors / Q000276:immunology* / Q000502:physiology; D007249:Inflammation / Q000276:immunology; D009504:Neutrophils / Q000276:immunology* / Q000502:physiology; D011817:Rabbits; D012867:Skin / Q000276:immunology*; D013997:Time Factors
chemical_list: D002630:Chemotactic Factors