title: The role of maximal oxygen uptake in exercise performance.
abstract: The maximal ability to deliver oxygen to the tissues of the body establishes the upper limit of endurance performance; however, the ability of the skeletal muscles to utilize a high oxygen load for a sustained period of time is also of great importance. The fatigue that limits endurance is due to a local limitation of oxygen or substrate, which leads to excessive anaerobic metabolism or decreased energy production. The peripheral adaptation from specific and intense training may further improve endurance performance.
mesh_terms: D000332:Aerobiosis; D000375:Aging; D000693:Anaerobiosis; D001823:Body Composition; D002302:Cardiac Output; D004734:Energy Metabolism; D005260:Female; D006321:Heart / Q000502:physiology; D006339:Heart Rate; D006801:Humans; D008297:Male; D009119:Muscle Contraction; D009132:Muscles / Q000098:blood supply / Q000378:metabolism; D010100:Oxygen / Q000502:physiology; D010101:Oxygen Consumption; D005082:Physical Exertion; D010809:Physical Fitness; D012039:Regional Blood Flow; D012119:Respiration; D014655:Vascular Resistance
chemical_list: D010100:Oxygen