title: Immunotherapy with alginate-conjugated and alum-precipitated grass pollen extracts in patients with allergic rhinoconjunctivitis.
abstract: In order to compare the safety and the efficacy of two grass pollen extracts made from the same starting material, i.e. equal proportions of cocksfoot and timothy, a 3-year study was made on patients with hay fever. One product was a dialysed aqueous extract of pollens which was chemically conjugated to activated sodium alginate ( Conjuvac ). The other was a pyridine-extracted alum-precipitated crude extract (Allpyral). Forty patients with classical hay fever were admitted to the study. All gave positive result to prick and nasal/conjunctival testing with extracts of both cocksfoot and timothy grass. Thirty-five patients completed all 3 years of the study. Seventeen/eighteen Allpyral-treated and 17/17 Conjuvac -treated patients were subjectively improved. There was no significant difference in symptom scores between the two groups. Challenge tests showed a tendency to reduced sensitivity to allergen in the Conjuvac -treated but not in the Allpyral-treated group. The median values for specific IgG and IgE showed the same pattern of reaction as seen in earlier studies of pollen hyposensitization. There was, however, a greater increase of grass-specific IgG in the Conjuvac -treated patients. No serious adverse effects were seen in any of the treatment groups, but there were slightly fewer side effects in the Conjuvac group.
mesh_terms: D000293:Adolescent; D000328:Adult; D000941:Antigens / Q000009:adverse effects / Q000627:therapeutic use; D039741:Antigens, Dermatophagoides; D003888:Desensitization, Immunologic; D005260:Female; D005500:Follow-Up Studies; D006023:Glycoproteins / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D009299:Nasal Provocation Tests; D010936:Plant Extracts / Q000627:therapeutic use*; D006109:Poaceae; D011058:Pollen; D011852:Radioallergosorbent Test; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology / Q000628:therapy*; D012882:Skin Tests
chemical_list: D000941:Antigens; D039741:Antigens, Dermatophagoides; D006023:Glycoproteins; D007136:Immunoglobulins; D010936:Plant Extracts; C038866:conjuvac