Hyperinsulinemia and hypertriglyceridemia, a vicious cycle with atherogenic potential.
This paper reviews and integrates a number of experiments which suggest the existence of a vicious cycle. In this cycle hypertriglyceridemia can lead to insulin resistance even without concomitant obesity or non-insulin dependent diabetes. This insulin resistance may be the basis for the hyperinsulinemia response to a glucose challenge. The hyperinsulinemia can stimulate VLDL-triglyceride production. This increase in production, if it is not accompanied by an equivalent increase in removal, will result in hypertriglyceridemia. The whole cycle would accelerate VLDL-triglyceride turnover and may increase the supply of potentially atherogenic VLDL-remnants.
D000818:Animals; D001161:Arteriosclerosis / Q000209:etiology*; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000494:pharmacology; D007333:Insulin Resistance; D008079:Lipoproteins, VLDL / Q000378:metabolism; D009765:Obesity / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D011972:Receptor, Insulin / Q000378:metabolism; D014280:Triglycerides / Q000097:blood* / Q000378:metabolism
D007328:Insulin; D008079:Lipoproteins, VLDL; D014280:Triglycerides; C030106:very low density lipoprotein triglyceride; D011972:Receptor, Insulin