Regional blood flow in compression-induced brain edema in rats: effect of dietary vitamin E.
Regional cerebral blood flow (rCBF) was studied autoradiographically in a murine model of focal epidural brain compression, and the effect of vitamin E administration was investigated. Mean cortical CBF was reduced to 0.48 to 0.50 ml/gm/min following 2 or 24 hours of compression. Early (2 hours) following subsequent decompression, a mixed pattern of hypoperfusion and hyperperfusion was observed. Twenty-four hours later, rCBF heterogeneities were less marked. Comparisons among animal groups raised on vitamin E-supplemented, vitamin E-normal, and vitamin E-deficient diets 2 hours after decompression revealed marked reductions in rCBF in the previously compressed cortex of the last two groups and hyperemia of the underlying hippocampus. The vitamin E-supplemented rats showed increased flow in the previously compressed cortex. In addition, vitamin E supplementation tended to eliminate rCBF gradients between subjacent zones. These data may help explain our previous observations of the beneficial effects of vitamin E on compression-induced brain edema.
D000818:Animals; D001921:Brain / Q000098:blood supply; D001929:Brain Edema / Q000188:drug therapy* / Q000503:physiopathology; D002545:Brain Ischemia / Q000188:drug therapy* / Q000209:etiology; D006407:Hematoma, Epidural, Cranial / Q000150:complications*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow; D014810:Vitamin E / Q000627:therapeutic use*
D014810:Vitamin E