Alterations in mammary-gland blood flow and glucose metabolism in the lactating rat induced by short-term starvation and refeeding.
Six-hour starvation of lactating rats caused a 75% decrease in mammary-gland lipogenesis. The inhibition of lipogenesis was accompanied by a 45% decrease of blood flow to the mammary gland and a 60% decrease in glucose uptake. Within 2 h of refeeding, lipogenesis and glucose uptake by the gland increased to fed values though blood flow to the gland remained at only 63% of that in the fed state. It is concluded that blood flow, and hence substrate supply, is not a rate-limiting factor for lipogenesis by the lactating mammary gland in the rat.
D000818:Animals; D005260:Female; D005502:Food; D005947:Glucose / Q000378:metabolism*; D007773:Lactates / Q000378:metabolism; D007774:Lactation; D019344:Lactic Acid; D008321:Mammary Glands, Animal / Q000098:blood supply* / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D012039:Regional Blood Flow; D013217:Starvation / Q000378:metabolism*
D007773:Lactates; D019344:Lactic Acid; D005947:Glucose