Influence of dialysis on prednisolone kinetics.
Six patients with end-stage renal disease were given prednisolone, 0.7-1.0 mg/kg/b.wt. parenterally. Prednisolone kinetics were investigated during dialysis, in 3 patients on hemodialysis and in 3 on continuous peritoneal dialysis, and also on days without dialysis. Mean plasma half-life was 250 min in five patients and 690 min in one patient who also suffered from intermittent porphyria. No change was found in prednisolone kinetics when the dialysis-free period was compared to the dialysis periods.
D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D010530:Peritoneal Dialysis; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011239:Prednisolone / Q000008:administration & dosage / Q000097:blood*; D006435:Renal Dialysis
D011239:Prednisolone