Effect of manganese treatment on the levels of neurotransmitters, hormones, and neuropeptides: modulation by stress.
Six weeks of daily intraperitoneal injection with manganese chloride (15 mg/kg body wt) reduced the normal weight gain of male Fischer-344 rats. This treatment depressed plasma testosterone and corticosterone levels, but prolactin levels were unaffected. The only significant changes in the levels of a variety of neuropeptides assayed in several regions were increases in the levels of hypothalamic substance P and pituitary neurotensin. Striatal serotonin, dopamine, and their metabolites were unchanged in manganese-exposed rats relative to saline-injected controls. However, the stress of injection combined with the effect of manganese appeared to significantly increase concentrations of striatal monoamines relative to uninjected controls.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003345:Corticosterone / Q000097:blood; D007274:Injections, Intraperitoneal; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008345:Manganese / Q000494:pharmacology*; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D011388:Prolactin / Q000097:blood; D011863:Radioimmunoassay; D051381:Rats; D011916:Rats, Inbred F344; D013312:Stress, Physiological; D013739:Testosterone / Q000097:blood
D009419:Nerve Tissue Proteins; D013739:Testosterone; D008345:Manganese; D011388:Prolactin; D007986:Luteinizing Hormone; D003345:Corticosterone