title: Technetium-fibrinogen lung scanning in canine lung contusion.
abstract: To detect experimentally induced acute lung contusion in anesthetized dogs, serial radionuclide images of the lung were recorded following intravenous infusion of 99mTc-labelled human fibrinogen (Tc-HF). The accumulation of Tc-HF in canine lungs was serially quantitated for up to 20 hours after lung contusion. A contusion (#1) was produced in one lung, Tc-HF was injected IV after 15 minutes, and 75 minutes later a contralateral lung contusion (#2) was produced in a series of 14 dogs. At autopsy the excised lungs were scanned, sectioned, and counted for radioactivity. Radiolabelled fibrinogen accumulated within 2-4 minutes of contusion #2 and remained stable over the next 20 hours in 14 dogs; contusion #1 was barely visible in four dogs. Lung Tc-HF activity in the central region of contusion #2 remained sixfold higher than in normal lung tissue. These data suggest that following lung contusion, fibrinogen deposition occurs rapidly and remains stable over a 20-hour interval of observation.
mesh_terms: D000818:Animals; D001769:Blood / Q000378:metabolism; D003288:Contusions / Q000150:complications / Q000000981:diagnostic imaging* / Q000503:physiopathology; D004285:Dogs; D005260:Female; D005340:Fibrinogen; D006406:Hematoma / Q000150:complications; D006470:Hemorrhage / Q000150:complications; D008168:Lung / Q000000981:diagnostic imaging* / Q000503:physiopathology; D055370:Lung Injury; D008297:Male; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D012711:Serum Albumin, Radio-Iodinated; D013667:Technetium; D013997:Time Factors
chemical_list: D015609:Organotechnetium Compounds; D012711:Serum Albumin, Radio-Iodinated; C036459:technetium Tc 99m fibrinogen; D013667:Technetium; D005340:Fibrinogen