Renal excretion of chromium-51 chloride in the dog.
To examine the renal handling of the trace element chromium, clearance studies were performed in pentobarbital sodium-anesthetized mongrel dogs following either gavage or intravenous administration of chromium-51(III) chloride. Ultrafilterable plasma chromium-51 comprised as much as 9-19% of the total plasma chromium-51 when the isotope was given by gavage but only 2-3% when given by intravenous infusion. The mean ratio of the clearance of ultrafilterable plasma chromium-51 to that of endogenous creatinine was approximately unity in all dogs [0.97 +/- 0.11 to 1.14 +/- 0.10 by gavage (n = 5); 0.84 +/- 0.05 to 0.97 +/- 0.05 intravenously (n = 4)]. Regardless of the route of administration, ultrafilterable plasma chromium-51 concentration and glomerular filtration rate appeared to be the primary determinants of renal chromium-51 excretion.
D000818:Animals; D002712:Chlorides; D002857:Chromium / Q000097:blood / Q000652:urine*; D017608:Chromium Compounds; D002860:Chromium Radioisotopes; D004285:Dogs; D005260:Female; D007668:Kidney / Q000502:physiology*; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D013696:Temperature; D014462:Ultrafiltration
D002712:Chlorides; D017608:Chromium Compounds; D002860:Chromium Radioisotopes; D002857:Chromium; C017133:chromous chloride