A method to potentiate enteral absorption of interferon and selective delivery into lymphatics.
The potentiated absorption of human fibroblast interferon (HuIFN-beta) with the aid of lipid-surfactant mixed micelles from the rat large intestine and lymphatic delivery were studied. The administration of HuIFN-beta with saline solution alone into the lumen of the large intestine indicated no detectable HuIFN-beta in the serum or the lymph for 5 h. Neither lipid (linoleic acid) nor surfactant ( HCO60 , polyoxyethylene hardened castor oil derivative) could promote the absorption of HuIFN-beta. However, the administration with linoleic acid- HCO60 mixed micelles enabled the great absorption of HuIFN-beta from the large intestine, and HuIFN-beta was delivered into the lymphatics with an extremely high selectivity.
D000818:Animals; D004357:Drug Synergism; D006801:Humans; D007370:Interferon Type I / Q000378:metabolism*; D007408:Intestinal Absorption; D007420:Intestine, Large / Q000378:metabolism; D008208:Lymphatic System / Q000378:metabolism*; D008297:Male; D008722:Methods; D008823:Micelles; D051381:Rats; D011916:Rats, Inbred F344
D007370:Interferon Type I; D008823:Micelles