title: Serial study of C reactive protein in neonatal septicaemia.
abstract: Serial C reactive protein concentrations were assayed by electroimmunoassay in 41 infants. Values in most of the non-infected infants were below 0.3 mg/dl, the lower limit of detection of C reactive protein by electroimmunoassay. Eleven of 12 infants with proved sepsis (positive blood cultures) had significantly raised concentrations and one infant with recurrent pseudomonas chest infection had a raised C reactive protein concentration. High C reactive protein concentrations were also found in infants with suspected infection. Successful treatment was followed by a decrease in the C reactive protein concentration. Total white blood cell count was not as appropriate as C reactive protein determination in the early identification of bacterial infection in the newborn.
mesh_terms: D002097:C-Reactive Protein / Q000378:metabolism*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000378:metabolism; D008297:Male; D011446:Prospective Studies; D011552:Pseudomonas Infections / Q000378:metabolism; D012008:Recurrence; D018805:Sepsis / Q000097:blood* / Q000175:diagnosis; D013997:Time Factors
chemical_list: D002097:C-Reactive Protein