Adenine metabolism in rat skeletal muscle.
Electrical stimulation, as anticipated brought about a fall in total ATP. Despite this there was little extra utilization of [8-14C]adenine to replace the ATP lost. The results suggest that allopurinol increased [8-14C]adenine utilization in both resting and stimulated muscle and, in particular, increased incorporation into ATP. After 30 minutes recovery total ATP levels had not returned to control resting values. [8-14C]adenine utilization, however, was markedly increased with most of the label incorporated into ATP. The results again suggest that addition of allopurinol to the medium increased [8-14C] adenine utilization of the label by recovering muscle.
D000225:Adenine / Q000378:metabolism*; D000255:Adenosine Triphosphate / Q000378:metabolism; D000493:Allopurinol / Q000494:pharmacology; D000818:Animals; D004558:Electric Stimulation; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000378:metabolism; D009119:Muscle Contraction; D009132:Muscles / Q000187:drug effects / Q000378:metabolism*; D051381:Rats
D007042:Hypoxanthines; D019271:Hypoxanthine; D000493:Allopurinol; D000255:Adenosine Triphosphate; D000225:Adenine