Cholinergic denervation of the hippocampal formation does not produce long-term changes in glucose metabolism.
Decreased glucose metabolism is found in Alzheimer's disease associated with a loss of cholinergic neurons. The relationship between the chronic cholinergic denervation produced by medial septal lesions and glucose metabolism was studied using 2-deoxy-D-[3H]glucose in the rat hippocampal formation. Hippocampal glucose metabolism was increased 1 week after medial septal lesions. Three weeks after lesions, glucose metabolism was profoundly suppressed in all regions. By 3 months, intraregional hippocampal glucose metabolism had returned to control values. Our results demonstrate that chronic cholinergic denervation of the hippocampal formation does not result in permanent alterations of metabolic activity.
D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D001345:Autoradiography; D002540:Cerebral Cortex / Q000378:metabolism; D003714:Denervation; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D009928:Organ Specificity; D051381:Rats; D014316:Tritium
D003837:Deoxy Sugars; D014316:Tritium; D003847:Deoxyglucose; D000109:Acetylcholine