Does incubator noise increase risks of aminoglycoside ototoxicity?
One group of newborn rats were given 50 mg/kg gentamicin for 20 days, 8 days after birth and were housed during the treatment in a regular incubator. They were compared to a similar group housed in regular cages and to two groups of unintoxicated newborn rats, one being exposed to the incubator noise and one being unexposed. Incubator noise was found to have no influence on gentamicin ototoxicity and to induce only a temporary threshold shift.
D000617:Aminoglycosides / Q000009:adverse effects; D000818:Animals; D000831:Animals, Newborn; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D001305:Auditory Fatigue / Q000187:drug effects; D001309:Auditory Threshold / Q000187:drug effects; D005839:Gentamicins / Q000009:adverse effects; D006198:Hair Cells, Auditory / Q000187:drug effects; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced*; D007186:Incubators, Infant; D009622:Noise / Q000009:adverse effects*; D009925:Organ of Corti / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012306:Risk
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins