Antidiuretic effect of perorally administered DDAVP in hydrated humans.
Urine volume and osmolality were measured in volunteers hydrated with drinking water (2% of body weight). During maintained water diuresis DDAVP (1-deamino-8-D-arginine vasopressin) dissolved in water was administered per os. Within 15-30 min a dose-dependent antidiuretic response occurred with a concomitant increase in urine osmolality. Administration of DDAVP through a duodenal tube caused similar antidiuretic effects indicating that the intact peptide can be absorbed from the intestinal mucosa.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001834:Body Water / Q000378:metabolism; D003894:Deamino Arginine Vasopressin / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D008297:Male; D009994:Osmolar Concentration; D014556:Urine; D014867:Water / Q000008:administration & dosage*
D014867:Water; D001127:Arginine Vasopressin; D003894:Deamino Arginine Vasopressin