Interspecific co-transfer of antibiotic resistance plasmids in staphylococci in vivo.
The co-transfer of plasmid-borne genes governing resistance to gentamicin, tetracycline, erythromycin and chloramphenicol has been demonstrated on human and mouse skin. Two different gentamicin resistance plasmids have been studied in detail; both appear to have the ability to mobilize in vivo otherwise non-transferable resistance plasmids from coagulase-negative to coagulase-positive staphylococci. This emphasis the role of the skin in maintaining a pool of resistance genes available to pathogenic staphylococci.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002701:Chloramphenicol / Q000494:pharmacology; D003227:Conjugation, Genetic; D004917:Erythromycin / Q000494:pharmacology; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D051379:Mice; D009355:Neomycin / Q000494:pharmacology; D011815:R Factors; D012867:Skin / Q000382:microbiology*; D013210:Staphylococcus / Q000187:drug effects / Q000235:genetics*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000235:genetics; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000235:genetics; D013752:Tetracycline / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D004917:Erythromycin; D002701:Chloramphenicol; D013752:Tetracycline; D009355:Neomycin