Subacute oral toxicity of tri-n-butyl phosphate in the Sprague-Dawley rat.
Tri-n-butyl phosphate was administered by gavage to male and female Sprague-Dawley rats for 14 consecutive days (low dose: 0.14 ml kg-1; high dose: 0.42 ml kg-1). Effects of this chemical were investigated at the end of the feeding period. Histopathological examination of the testes (high-dose group) showed the presence of microscopic degenerative changes in the seminiferous tubules. No other abnormal microscopic changes were observed.
D000284:Administration, Oral; D000818:Animals; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010755:Organophosphates / Q000008:administration & dosage / Q000633:toxicity*; D009943:Organophosphorus Compounds / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013737:Testis / Q000187:drug effects* / Q000473:pathology
D010755:Organophosphates; D009943:Organophosphorus Compounds; C009524:tributyl phosphate