title: [Prenatal action of tetracycline hydrochloride on lymph node development in the rat].
abstract: Histological and morphological methods were used to study the ante- and postnatal development of tracheobronchial and mesenterial nodes of white rats exposed to tetracycline in the preimplantation period (days 1-6 of the embryogenesis), during placentation and early organogenesis (days 8-13), and in the late organogenesis (days 14-19). Administration of tetracycline on days 1-6 and 8-13 of the embryogenesis disturbs the formation of the morphofunctional structures of the node, inhibits the lympho- and plasmocytopoiesis associated with a dramatic increase in the number of granulocytes and mast cells. Exposure to the antibiotic on days 14-19 of the embryo-genesis does not impair the formation of the lymph nodes but leads to an increase in them of the number of lymphocytes, plasmocytes, macrophages, eosinophilic granulocytes and mast cells.
mesh_terms: D000818:Animals; D001980:Bronchi; D005260:Female; D008198:Lymph Nodes / Q000187:drug effects* / Q000196:embryology / Q000254:growth & development; D008643:Mesentery; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains; D013752:Tetracycline / Q000633:toxicity*; D013997:Time Factors; D014132:Trachea; D014436:Typhoid-Paratyphoid Vaccines / Q000276:immunology
chemical_list: D014436:Typhoid-Paratyphoid Vaccines; D013752:Tetracycline
vernacular_title: Prenatal'noe deĭstvie tetratsiklina gidrokhlorida na razvitie limfaticheskikh uzlov u krys.