[Radiomodifying effect of serotonin on the cells of the hematopoietic system].
Mice were injected with serotonin (0.5 and 2.0 mg/mouse) 15 min before and immediately after irradiation (4.5 and 7.0 Gy). With the preparation administered prior to irradiation one could observe an increase in the quantity of CFUc survived (endo- and exo-test), acceleration of restoration of cellularity (in the bone marrow) and growth of the spleen weight. The acceleration of restoration of the bone-marrow cellularity was also noted when serotonin was administered after irradiation. The post-irradiation effect of serotonin was also detected in cells in vitro. It is concluded that the radiomodifying effect of serotonin on the haemopoietic system is due to a decrease in the number of damaged cells and increase in the rate of reproduction of intact cells.
D000818:Animals; D001921:Brain / Q000473:pathology / Q000528:radiation effects*; D002455:Cell Division; D006412:Hematopoietic Stem Cells / Q000473:pathology / Q000528:radiation effects*; D066298:In Vitro Techniques; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D051381:Rats; D012701:Serotonin / Q000494:pharmacology* / Q000627:therapeutic use
D012701:Serotonin
Issledovanie puteĭ realizatsii radiomodifitsiruiushchego deĭstviia serotonina na kletki krovetvornoĭ sistemy.