Peculiarities of the composition and functional state of lymphocytes in patients with impaired bone tissue regeneration.
In patients with delayed bone tissue regeneration, changes in the indices of cellular immunity were revealed, consisting in a decreased number, both absolute and relative, of T lymphocytes, and in their reduced ability to respond to PHA stimulation by the reaction of blastic transformation. Autoimmunization to bone tissue antigen was observed in the same patients. This was confirmed by the reactions of blastic transformation and cytotoxicity of lymphocytes as well as by the reaction of leukocyte migration inhibition in the presence of bone antigen. It is recommended to take into account the indices of cellular immunity in treating patients with poorly healing bone fractures.
D000328:Adult; D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005260:Female; D050723:Fractures, Bone; D006801:Humans; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D013601:T-Lymphocytes / Q000276:immunology*; D014945:Wound Healing
D007961:Leukocyte Migration-Inhibitory Factors