title: Intracytoplasmic collagen fibers observed in cartilage of the pathological conditions.
abstract: The young male rabbit ear cartilage after intravenous injection of chymopapain was studied by electron microscope. Fibrous long spacing (FLS)-like fibers were observed in the cytoplasm of the cartilage cells. These fibers were then compared with segment long spacing (SLS) fibers within the golgi vacuoles in the secondary well differentiated chondrosarcoma cells. These collagen fiber formation do not represent a normal collagen fiber formation, but it may be possible that the tropocollagen molecules are aggregated in the golgi vacuoles in a manner characteristic to FLS or SLS fiber by the close relationship with lysosome.
mesh_terms: D000818:Animals; D001859:Bone Neoplasms / Q000378:metabolism; D002356:Cartilage / Q000378:metabolism*; D002813:Chondrosarcoma / Q000378:metabolism; D002917:Chymopapain; D003094:Collagen / Q000378:metabolism*; D003095:Collagen Diseases / Q000139:chemically induced / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D011347:Procollagen / Q000378:metabolism; D011817:Rabbits
chemical_list: D011347:Procollagen; D003094:Collagen; D002917:Chymopapain