title: [New aspects in the antiemetic therapy of cytostatic drug-induced vomiting].
abstract: The present intensification of cancer chemotherapy has resulted in increased toxicity. Nausea and vomiting are often severe and prolonged, rendering a patient unfit for further treatment. This review summarizes the current understanding of the physiology of vomiting and the pharmacology and efficacy of the antiemetics in clinical use. It also discusses new approaches with agents, such as cannobinoids, high-dosage metoclopramide, and high-dosage corticosteroids. The new agents are superior to standard antiemetic drugs as demonstrated in a number of trials.
mesh_terms: D000932:Antiemetics / Q000627:therapeutic use*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002186:Cannabinoids / Q000627:therapeutic use; D002628:Chemoreceptor Cells / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008526:Medulla Oblongata / Q000187:drug effects; D008787:Metoclopramide / Q000627:therapeutic use; D009369:Neoplasms / Q000188:drug therapy*; D014839:Vomiting / Q000139:chemically induced* / Q000188:drug therapy
chemical_list: D000932:Antiemetics; D000970:Antineoplastic Agents; D002186:Cannabinoids; D008787:Metoclopramide
vernacular_title: Neue Aspekte der antiemetischen Therapie bei Zytostatika-induziertem Erbrechen.