Altered baroreceptor inputs to the supraoptic nucleus of the Brattleboro rat.
In Brattleboro rats, many more supraoptic neurones are baroresponsive than in normal rats. This may reflect the more widespread noradrenergic innervation of the supraoptic nucleus in Brattleboro rats. If so, the present data suggest that baroreceptor influences on vasopressin secretion are mediated by a noradrenergic pathway and that the altered responsiveness reflects the altered innervation.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D008297:Male; D009638:Norepinephrine / Q000502:physiology; D010656:Phenylephrine / Q000494:pharmacology; D011311:Pressoreceptors / Q000502:physiology*; D051381:Rats; D011910:Rats, Brattleboro / Q000502:physiology*; D011922:Rats, Mutant Strains / Q000502:physiology*; D013495:Supraoptic Nucleus / Q000502:physiology*; D014667:Vasopressins / Q000502:physiology
D014667:Vasopressins; D010656:Phenylephrine; D009638:Norepinephrine