title: Rapid cyclic fluctuations of blood pressure associated with an adrenal pheochromocytoma.
abstract: We present a patient with an adrenal pheochromocytoma with an unusual pattern of periodic alternating hypertension and hypotension. Alpha-adrenergic blockade alone failed to affect this pattern, which was abolished only after fluid repletion. The efficacy of volume expansion in ultimately correcting the wide fluctuations of blood pressure implicates a possible reflex neurogenic mechanism for the cyclic changes in blood pressure attributable to intravascular volume contraction.
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000503:physiopathology; D000368:Aged; D001794:Blood Pressure; D005440:Fluid Therapy; D006801:Humans; D006973:Hypertension / Q000209:etiology* / Q000628:therapy; D007022:Hypotension / Q000209:etiology* / Q000628:therapy; D008297:Male; D010507:Periodicity; D010646:Phentolamine / Q000627:therapeutic use; D010673:Pheochromocytoma / Q000150:complications* / Q000503:physiopathology
chemical_list: D010646:Phentolamine