Effect of quinidine on the intestinal secretion of digoxin in guinea pigs.
Following i.v. injection of digoxin (10 micrograms kg-1) the ratio between digoxin concentrations in the lumen of jejunal loops perfused in situ and in plasma (L/P) of guinea pigs increased linearly with time. After 3 h, L/P was 8.7, indicating net secretion of digoxin against a concentration gradient. In quinidine treated animals (100 mg kg-1 p.o., 2 h before experiment) both the L/P ratio (5.7; p less than 0.01) and the digoxin content of jejunal tissue (-32 per cent; p less than 0.01) were markedly reduced. It is suggested that quinidine reduces the extrarenal clearance of digoxin at least in part by inhibiting the intestinal secretion of this glycoside.
D000818:Animals; D004077:Digoxin / Q000378:metabolism*; D004347:Drug Interactions; D006168:Guinea Pigs; D007419:Intestinal Secretions / Q000187:drug effects* / Q000378:metabolism; D007583:Jejunum / Q000378:metabolism*; D007700:Kinetics; D011802:Quinidine / Q000494:pharmacology*
D004077:Digoxin; D011802:Quinidine