Antimutagenic effects on male germ cells of mice.
The alkylating agent cyclophosphamide (CPA) and the antioxidant ethoxyquin (EQ) were administered perorally to NMRI mice. The strong clastogenic action of CPA on spermatogonia was diminished by simultaneous doses of EQ. Higher doses of the antioxidant produced greater anticlastogenic action. Furthermore, the action of the mutagen and the antioxidant on the late spermatids and the spermatozoa was observed using the dominant lethal test. The antioxidant had only a weak influence on these postmeiotic stages.
D000284:Administration, Oral; D000818:Animals; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005015:Ethoxyquin / Q000008:administration & dosage / Q000494:pharmacology*; D005799:Genes, Dominant / Q000187:drug effects; D005804:Genes, Lethal / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D011804:Quinolines / Q000494:pharmacology*; D013093:Spermatogonia / Q000187:drug effects* / Q000502:physiology; D013094:Spermatozoa / Q000187:drug effects*
D009153:Mutagens; D011804:Quinolines; D003520:Cyclophosphamide; D005015:Ethoxyquin