Androgenic control of acetate incorporation into phospholipids and triacylglycerols in rat ventral prostate.
To obtain information about androgenic hormone actions on the synthesis of lipids from [1-14C]acetate in rat ventral prostate, in vitro and in vivo experiments have been carried out. The time course of incorporation of labelled acetate was studied. Also different solubilization media of androgenic hormones was investigated. We have selected Tween-80. Results for in vitro experiments, show that increasing concentrations of testosterone and dihydro-testosterone correspond to an increase in the incorporation of labelled acetate into phospholipids and a decrease in the incorporation into triacylglycerols. In vivo experiments of incorporation of [1-14C]acetate have also been carried out and show a similar pattern to the situation found in our in vitro experiments.
D000085:Acetates / Q000378:metabolism*; D019342:Acetic Acid; D000818:Animals; D002250:Carbon Radioisotopes; D013196:Dihydrotestosterone / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D010743:Phospholipids / Q000096:biosynthesis*; D011467:Prostate / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000494:pharmacology*; D014280:Triglycerides / Q000096:biosynthesis*
D000085:Acetates; D002250:Carbon Radioisotopes; D010743:Phospholipids; D014280:Triglycerides; D013196:Dihydrotestosterone; D013739:Testosterone; D019342:Acetic Acid