title: Accuracy of the diagnosis in suspected intraepithelial neoplasia of the cervix.
abstract: 520 patients with a preoperative diagnosis of cervical intraepithelial neoplasia (CIN) were operated. The diagnoses obtained by colposcopically directed biopsy and endocervical curettage were compared with those obtained by cone biopsy or/and hysterectomy. Underdiagnosis occurred in 18.9% of the cases, if severe dysplasia and carcinoma in situ were considered to be separate conditions. When these two diagnoses were combined as CIN 3 the underdiagnosis rate declined to 11.0%. CIN 3 changed to invasive carcinoma in 1.5% and to microinvasive carcinoma in 4.4% of the cases. The preoperative diagnosis of CIN seems not to be accurate enough to make cone biopsy totally unnecessary as a complementary diagnostic step.
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001706:Biopsy; D002277:Carcinoma / Q000473:pathology* / Q000601:surgery; D002278:Carcinoma in Situ / Q000473:pathology* / Q000601:surgery; D002584:Cervix Uteri / Q000473:pathology*; D003127:Colposcopy; D003475:Curettage; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D002578:Uterine Cervical Dysplasia / Q000473:pathology* / Q000601:surgery; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000601:surgery