[Clinical, cardio- and hemodynamic effects of long- and short-acting beta-adrenergic blockers in the treatment of patients with stable stenocardia].
Sixty-nine coronary heart disease patients with stable angina of effort of Classes II-IV of functional activity were studied for the effect of three nonselective beta-adrenergic blockers on the incidence and intensity of angina attacks, on the tolerance to exercise on the bicycle ergometer, as well as on the heart rate, arterial pressure, cardiac volumes and intracardiac hemodynamics using a complex of clinical and instrumental methods. It was proved that nadolol, pindolol and propranolol hydrochloride possessed similar anti-anginal effects but nadolol exerted the greatest negative chronotropic action while propranolol hydrochloride exerted a negative inotropic action. As regards the degree of the effect on cardiac volumes, corgard (nadolol) occupied an intermediate position between anaprilin (propranolol hydrochloride) and visken (pindolol).
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy* / Q000503:physiopathology; D005080:Exercise Test; D005260:Female; D006439:Hemodynamics; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction; D009248:Nadolol; D010869:Pindolol / Q000627:therapeutic use*; D011412:Propanolamines / Q000009:adverse effects / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use*
D011412:Propanolamines; D009248:Nadolol; D011433:Propranolol; D010869:Pindolol
Klinicheskie, kardio- i gemodinamicheskie éffekty neselektivnykh beta-adrenergicheskikh blokatorov prolongirovannogo i korotkogo deĭstviia pri lechenii bol'nykh stabil'noĭ stenokardieĭ.