Chromosomes in human large bowel tumors. A study of chromosome #1.
Chromosome studies on 49 patients with large bowel adenocarcinomas showed abnormalities of chromosome #1 in 19 cases (39%). One had monosomy, 13 showed trisomy, and 5 cases had structural abnormalities. Eighteen patients had tumors on the right side of the colon; of these, only 3 had an abnormal #1 (17%); 16 of 28 tumors (57%) located on the left side had abnormalities of #1. The regions of consistent duplication of 1q were q24----q44? The presence or absence of changes of chromosome #1 may be useful as a prognostic indicator in large bowel cancer.
D000230:Adenocarcinoma / Q000235:genetics*; D002869:Chromosome Aberrations; D002900:Chromosomes, Human, 1-3; D006801:Humans; D007414:Intestinal Neoplasms / Q000235:genetics*; D007420:Intestine, Large; D007621:Karyotyping; D014314:Trisomy