title: Inhibition of Leishmania amastigote growth by antipain and leupeptin.
abstract: Antipain and leupeptin were found to be potent inhibitors of the growth of Leishmania mexicana mexicana amastigotes in explanted mouse unstimulated peritoneal macrophages. Antipain at 100 mg l-1 reduced eight-fold the percentage of macrophages infected and to 5% of the control the number of amastigotes present after seven days incubation. At 1 mg l-1, antipain and leupeptin were as effective antileishmanial agents as pentamidine isethionate, all three stopping parasite multiplication over the seven-day incubation.
mesh_terms: D000818:Animals; D000976:Antipain / Q000494:pharmacology*; D000981:Antiprotozoal Agents; D007891:Leishmania / Q000187:drug effects* / Q000254:growth & development; D007976:Leupeptins / Q000494:pharmacology*; D008264:Macrophages / Q000469:parasitology; D051379:Mice; D008826:Microbial Sensitivity Tests; D009842:Oligopeptides / Q000494:pharmacology*; D010419:Pentamidine / Q000494:pharmacology
chemical_list: D000981:Antiprotozoal Agents; D007976:Leupeptins; D009842:Oligopeptides; D000976:Antipain; D010419:Pentamidine; C032854:leupeptin