The effect of methyl-2-tetradecylglycidate (McNeil 3716) on heart mitochondrial metabolism in rats.
Methyl-2- tetradecylglycidate (MTG), one of a new class of hypoglycemic agents, given to healthy rats, prompted uncoupling of oxidative phosphorylation in heart mitochondria (measured ex vivo) without a concomitant effect on mitochondrial electron transfer reactions. At the same time heart creatinephosphate -kinase was inhibited and subsequently the semipermeability of the inner mitochondrial membrane was impaired as demonstrated by an influx of creatine. The triglyceride and total phospholipid content of heart tissue and its mitochondria showed a transient elevation. The hearts were enlarged, flabby and discoloured and had dilated ventricles. These effects could be the account of an adverse effect of MTG on the heart energy metabolism.
D000818:Animals; D003401:Creatine / Q000032:analysis; D003402:Creatine Kinase / Q000032:analysis; D004734:Energy Metabolism / Q000187:drug effects*; D004852:Epoxy Compounds / Q000494:pharmacology*; D004988:Ethers, Cyclic / Q000494:pharmacology*; D005260:Female; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D010743:Phospholipids / Q000032:analysis; D011422:Propionates / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D014280:Triglycerides / Q000032:analysis
D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D007004:Hypoglycemic Agents; D010743:Phospholipids; D011422:Propionates; D014280:Triglycerides; D003402:Creatine Kinase; D003401:Creatine; C017522:methyl 2-tetradecylglycidate