[Radiosensitivity of stromal mechanocytes in human bone marrow and spleen].
The monolayer cultivation of the bone marrow and spleen from patients with Hodgkin's disease was done. The content of stromal precursor cells (CFU-F) varies significantly in the human spleen (1.2-26.4 per each 10(6) incubated in the culture of nucleated cells) and is approximately one order lower than in the bone marrow (2.1-53.8 per 10(5) myelokaryocytes). During exposure to 60Co gamma-rays the values of a mean lethal cell dose (D0) for splenic CFU-F proved to be higher (2.03 +/- 0.17 Gy) than those for CFU-F from the bone marrow (1.49 +/- 0.12 Gy).
D001853:Bone Marrow / Q000528:radiation effects*; D001854:Bone Marrow Cells; D002470:Cell Survival / Q000528:radiation effects; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D004307:Dose-Response Relationship, Radiation; D005347:Fibroblasts / Q000166:cytology / Q000528:radiation effects; D006689:Hodgkin Disease / Q000473:pathology; D006801:Humans; D011836:Radiation Tolerance; D013154:Spleen / Q000166:cytology / Q000528:radiation effects*
Radiochuvstvitel'nost' stromal'nykh mekhanotsitov kostnogo mozga i selezenki cheloveka.