Inhibition by PGI-2 of myometrial activity in vivo in non-pregnant ovariectomized sheep.
The effects of PGI-salt and PGI-2 methyl ester on intrauterine pressure (IUP) and uterine electromyographic activity (EMG) were examined in vivo in non-pregnant ovariectomized sheep. PGI-2 salt and PGI-2 methyl ester (50--200 micrograms) reduced significantly the frequency and amplitude of IUP cycles and also inhibited the associated uterine EMG activity. Injections of oxytocin (50 mU) or PGF-2 alpha (2 micrograms) partly overcame the inhibiton of IUP induced by the PGI-2 methyl ester. These results suggest that endogenous PGI-2 may be involved in the regulation of uterine activity in sheep.
D000818:Animals; D002369:Castration; D015237:Dinoprost; D004576:Electromyography; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D009215:Myometrium / Q000187:drug effects / Q000502:physiology*; D010121:Oxytocin / Q000494:pharmacology; D011312:Pressure; D011453:Prostaglandins / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology; D012756:Sheep; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000502:physiology*
D011453:Prostaglandins; D011460:Prostaglandins F; D010121:Oxytocin; D015237:Dinoprost; D011464:Epoprostenol