title: Negative dose-response study for carcinogenicity of orally administered rutin sulfate in Sprague-Dawley rats.
abstract: Rutin is a ubiquitous naturally occurring flavonoid, which is used in a number of drugs. It was tested for carcinogenicity in Sprague--Dawley rats as a water-soluble mixture of sodium salts of sulfuric acid esters. Over 2 years, doses ranging from 10 to 500 mg/kg body wt of rutin sulfate (expanding factor 2.66) were administered by gavage 3 times a week to 4 groups of rats comprising 12 males and 12 females each. A control group was treated with tap water. Age-adjusted analysis of tumor rates did not provide any evidence for rutin sulfate to be carcinogenic under the conditions of this bioassay.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002273:Carcinogens; D005260:Female; D008297:Male; D009369:Neoplasms / Q000139:chemically induced*; D051381:Rats; D011919:Rats, Inbred Strains; D012431:Rutin / Q000633:toxicity*
chemical_list: D002273:Carcinogens; D012431:Rutin