Presence of a paradoxical sleep (PS) factor in the cerebrospinal fluid of PS-deprived rats.
The lack of paradoxical sleep (PS) observed in rats after pharmacological blockade of the noradrenergic beta-receptors was reversed by intraventricular infusion of cerebrospinal fluid (CSF) from PS-deprived donor rats. The PS restoration in recipient animals was proportional to the duration of the deprivation in donors. It is concluded that some PS-inducing factor progressively accumulates in the CSF during deprivation. This factor acts beyond the noradrenergic step in the regulation of PS.
D000818:Animals; D002555:Cerebrospinal Fluid / Q000502:physiology*; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D012892:Sleep Deprivation / Q000502:physiology*; D012895:Sleep, REM / Q000187:drug effects / Q000502:physiology*
D011433:Propranolol