Treatment of experimental cutaneous leishmaniasis with liposome-intercalated amphotericin B.
The therapeutic efficacy of a liposomal preparation of amphotericin B was evaluated in two murine models of cutaneous leishmaniasis. No significant decrease in tissue parasite density was observed in C57BL/6 mice after systemic treatment instituted seven days after footpad inoculation with Leishmania tropica; in contrast, BALB/c mice showed a modest response.
D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D005260:Female; D007891:Leishmania / Q000187:drug effects; D007896:Leishmaniasis / Q000188:drug therapy* / Q000469:parasitology; D008081:Liposomes / Q000008:administration & dosage*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL
D008081:Liposomes; D000666:Amphotericin B