Opposite effects of extracellular sodium removal on the uptake of tryptophan into rat cortical slices and synaptosomes.
The removal of extracellular sodium decreased L-tryptophan (L-TRP) uptake into brain slices but increased uptake into synaptosomes. The uptake of 5-hydroxytryptamine (5-HT) was inhibited in both preparations under these conditions. It is suggested that the different effects on L-TRP uptake may be due to differences in cellular composition between the two preparations rather than to any differences in sample handling.
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000378:metabolism; D012964:Sodium / Q000378:metabolism*; D013574:Synaptosomes / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism*
D012701:Serotonin; D014364:Tryptophan; D012964:Sodium