title: Thymus-independent crypt hyperplasia and villous atrophy in the small intestine of mice infected with the trematode Echinostoma revolutum.
abstract: Conventional mice and congenitally athymic, nude mice were infected with 20 metacercariae of the intestinal trematode Echinostoma revolutum. The sequential events in the pathological changes in the intestine were studied at different intervals post-infection. By day 11 onwards the conventional mice displayed dilatation of the region of the intestine which harboured the parasites. The mucosa in the dilated region showed marked crypt hyperplasia, villous atrophy and subepithelial fibrosis as the most conspicuous features which, together with a hypertrophy of the muscular layers, made the wall of the gut in the dilated region thicker than normal. The changes were thymus-independent as they were found to be as severe in the athymic, nude mice as in the conventional mice. The main histological features observed in the mice are discussed in relation to other conditions with similar changes, such as coeliac disease, nippostrongyliasis and trichinellosis. It is concluded that the present results support the view that there may be more than one effector mechanism of the change.
mesh_terms: D000818:Animals; D001284:Atrophy / Q000473:pathology; D004451:Echinostomiasis / Q000473:pathology*; D005260:Female; D006965:Hyperplasia / Q000473:pathology; D007413:Intestinal Mucosa / Q000473:pathology*; D007421:Intestine, Small / Q000473:pathology*; D051379:Mice; D008819:Mice, Nude; D013950:Thymus Gland / Q000502:physiology*; D013997:Time Factors; D014201:Trematode Infections / Q000473:pathology*