title: Clinical use of pressure-dimension and stress-shortening relations in systole and diastole.
abstract: The concept of time-varying elastance is an important one and has clinical relevance for both systole and diastole. The application of this concept to systole has permitted the development of end-systolic pressure-volume (dimension) and stress-shortening analysis as a method of assessing myocardial contractility in patients at risk for congestive cardiomyopathy. The application of the time-varying elastance concept to diastole is particularly relevant to new findings concerning abnormal relaxation in hypertrophic cardiomyopathy and angina pectoris.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002118:Calcium / Q000502:physiology; D002302:Cardiac Output; D002648:Child; D002675:Child, Preschool; D003971:Diastole; D004317:Doxorubicin / Q000009:adverse effects; D004548:Elasticity; D006331:Heart Diseases / Q000209:etiology / Q000503:physiopathology*; D006333:Heart Failure / Q000139:chemically induced / Q000503:physiopathology; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D009200:Myocardial Contraction; D013318:Stroke Volume; D013599:Systole; D013789:Thalassemia / Q000628:therapy; D065227:Transfusion Reaction
chemical_list: D004317:Doxorubicin; D002118:Calcium