title: Effects of ethacrynic acid in the newborn infant.
abstract: The effects of ethacrynic acid on electrolyte and water excretion were examined in 10 neonates with fluid overload states. Ethacrynic acid (1 mg/kg IV) produced a 10-fold increase in FENa+ and FECl - and a sixfold increase in urine volume and osmolar clearance. These effects peaked within 1 hour of ethacrynic acid administration, and progressively decreased to the baseline value by 5 hours after drug administration. The mean excretion of potassium increased by 280% in 1 hour, and returned to baseline value after 5 hours. The mean Ca++ excretion increased fourfold after 1 hour, and the effect lasted for 4 hours. Two infants developed mild hyponatremia. Our data emphasize the prolonged diuretic and saluretic effect of ethacrynic acid in neonates.
mesh_terms: D002712:Chlorides / Q000652:urine; D004231:Diuresis / Q000187:drug effects; D004976:Ethacrynic Acid / Q000494:pharmacology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D012964:Sodium / Q000652:urine; D014882:Water-Electrolyte Balance / Q000187:drug effects*
chemical_list: D002712:Chlorides; D012964:Sodium; D004976:Ethacrynic Acid