title: [Efficacy of a new antisecretory agent (40 749 RP) on human gastric secretion induced by a meal (intragastric titration)].
abstract: An antisecretory drug of a new series, 40 749 RP, without anticholinergic or H2 receptor antagonist activities, was tested on meal-induced gastric acid secretion in 6 healthy volunteers. Gastric acid secretion and emptying of liquid were measured using intragastric titration. Oral dosages tested were 1, 2 and 4 mg/kg versus placebo. Inhibitions obtained were dose-related and expressed in percentage of the placebo values: 36 +/- 10 p. 100 for 1 mg/kg; 51 +/- 13 p. 100 for 2 mg/kg and 83 +/- 5 p. 100 for 4 mg/kg. Statistically significant correlation (p less than 0.001) was observed between maximal blood concentration of 40 749 RP and the percentage of secretory inhibition during the 90 min of the test. No change in gastrin response or in gastric emptying was observed whatever the dose.
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004435:Eating; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005746:Gastric Emptying / Q000187:drug effects; D006801:Humans; D008297:Male; D013876:Thiophenes / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D013876:Thiophenes; C034498:RP 40749
vernacular_title: Efficacité d'un nouvel antisécrétoire (40 749 RP) sur la sécrétion gastrique de l'homme induite par le repas (titration intra-gastrique).