Pharmacokinetic study of digoxin-benzamide interaction in the rat.
Simultaneous oral administration of digoxin and three benzamides (Metoclopramide, Alizapride, Bromopride) to the rat, modify digoxin's pharmacokinetic parameters: peak plasma concentration, elimination phase half life and bioavailability (Bromopride, Alizapride in function with dose-level). Our conclusion, is that drug-monitoring is necessary for this drug association.
D000284:Administration, Oral; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D004077:Digoxin / Q000008:administration & dosage* / Q000097:blood; D004347:Drug Interactions; D007700:Kinetics; D008787:Metoclopramide / Q000008:administration & dosage* / Q000031:analogs & derivatives; D011759:Pyrrolidines / Q000008:administration & dosage*; D011863:Radioimmunoassay; D051381:Rats
D000889:Anti-Arrhythmia Agents; D011759:Pyrrolidines; D004077:Digoxin; C013855:bromopride; D008787:Metoclopramide; C033968:alizapride