Low incidence of gross leukemia virus-induced lymphomas in spontaneously hypertensive rats with thymic dysfunction.
We compared the incidence of lymphomas induced by Gross leukemia virus (GLV) between spontaneously hypertensive rats (SHR) with a congenital T-cell depression related to thymic dysfunction and normal Wistar rats, the original strain of SHR. Of 20 SHR given neonatal injections of GLV, only 3 (15%) died with thymic lymphomas about 100 days after the virus infection. In contrast, 27 of 28 Wistar rats (96%) developed lymphomas of mostly thymic origin. The 3 lymphomas derived from the SHR bore only a Thy 1.1 antigen, whereas most of the lymphomas derived from Wistar rats carried not only a Thy 1.1 antigen but also a guinea pig red blood cell rosette receptor and a T (W3/13) antigen. Grafts of 1-week-old male Wistar thymus into the neonatal female SHR promoted a differentiation of thymocytes and markedly increased the incidence of the lymphomas which were positive for a guinea pig red blood cell rosette receptor and a T-antigen; grafts of 1-week-old SHR thymus, however, failed to do this. These results suggest that the low incidence of GLV-induced lymphomas in SHR may correlate closely with the absence or decreased numbers of the rosette-forming thymocytes which are presumably the target cells for GLV.
D000406:AKR murine leukemia virus / Q000472:pathogenicity*; D000818:Animals; D000954:Antigens, Surface / Q000032:analysis; D003602:Cytotoxicity, Immunologic; D006973:Hypertension / Q000150:complications / Q000276:immunology*; D007113:Immunity, Innate; D007942:Leukemia, Experimental / Q000150:complications / Q000276:immunology* / Q000382:microbiology; D008206:Lymphatic Diseases / Q000150:complications / Q000276:immunology*; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D011922:Rats, Mutant Strains; D013950:Thymus Gland / Q000276:immunology* / Q000637:transplantation
D000954:Antigens, Surface