title: Long-term study of large ceramic implants (porous hydroxyapatite) in dog femora.
abstract: Blocks of porous ceramic hydroxyapatite (dimensions, 2.5 X 1.25 X 0.5 cm; sintering temperature, 1300 degrees; macroporosity, 56%; average pore size 0.18 mm2) were implanted into surgically created defects in dog femora. The implants were retrieved up to 3.5 years after implantation. The implants were 3.5 years after implantation. The implants were firmly attached to the bone. Histologic evaluation suggests that optimal contact between bone and implant should be provided to accelerate bone ingrowth. Bone growth in the pores reached a maximum level after 35 weeks, at which time about one-third of the pore space was filled with bone. When measuring the relative surface areas of bone and ceramic on histologic slides, no change in ceramic mass could be detected, indicating that hydroxyapatite ceramics are not affected by biodegradation processes. The implants effectively provided a scaffold for bone growth bridging a larger bone defect.
mesh_terms: D000818:Animals; D001711:Biotransformation; D001846:Bone Development / Q000187:drug effects; D004285:Dogs; D005269:Femur / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D006882:Hydroxyapatites / Q000378:metabolism / Q000494:pharmacology*; D019736:Prostheses and Implants; D013997:Time Factors
chemical_list: D006882:Hydroxyapatites