Serum inhibitor in systemic lupus erythematosus associated with aplastic anemia.
Hematologic complications of systemic lupus erythematosus (SLE) usually involve peripheral destruction of blood elements. We report a case of SLE-associated aplastic anemia in which an IgG complement-dependent antibody, obtained from the patient's disease-phase serum but not remission-phase serum, suppressed growth of granulocyte-macrophage progenitor cells from bone marrow of normal donors in vitro. Therapy with plasmapheresis and immunosuppression resulted in lasting remission.
D000293:Adolescent; D000741:Anemia, Aplastic / Q000097:blood / Q000209:etiology* / Q000276:immunology; D000961:Antilymphocyte Serum; D003114:Colony-Forming Units Assay; D003165:Complement System Proteins / Q000378:metabolism; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis / Q000276:immunology*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications* / Q000276:immunology
D000961:Antilymphocyte Serum; D007074:Immunoglobulin G; D003165:Complement System Proteins