The anti-arthritic and immunosuppressive effects of cyclosporine on arthritis induced in the rat by type II collagen.
The influence of cyclosporine (CsA) on the induction and pathogenesis of type II collagen-induced arthritis has been investigated in inbred and outbred Wistar rats. The proportion of animals developing disease and the severity of disease they developed were both diminished by treatment with CsA. These effects were accompanied by a marked suppression of the antibody response to both the immunizing collagen and also to rat type II collagen. CsA treatment also resulted in a decreased accumulation of lymphocytes in arthritic joints. The results indicate that the anti-arthritic and immunosuppressive effects of CsA probably result from a modification of both systemic antibody-mediated and local cell-mediated immunity.
D000818:Animals; D000917:Antibody Formation; D001168:Arthritis / Q000517:prevention & control*; D001169:Arthritis, Experimental / Q000209:etiology / Q000276:immunology / Q000517:prevention & control*; D001323:Autoantibodies / Q000096:biosynthesis; D001327:Autoimmune Diseases / Q000276:immunology / Q000517:prevention & control*; D002464:Cell Migration Inhibition; D003094:Collagen / Q000276:immunology*; D003524:Cyclosporins / Q000627:therapeutic use*; D008214:Lymphocytes / Q000276:immunology; D051381:Rats; D011919:Rats, Inbred Strains
D001323:Autoantibodies; D003524:Cyclosporins; D003094:Collagen