Fluoro-substituted N-nitrosamines. 4. Comparative genotoxic activities of N-nitrosodibutylamine and three fluorinated analogues in two bacterial systems.
N-Nitrosodibutylamine (NDBA) and three fluorinated analogues (N-nitroso (4,4,4-trifluorobutyl-amine, F3NDBA; N-nitrosobis (4,4,4-trifluorobutyl)amine, F6NDBA; and N-nitrosobis (2,2,3,3,4,4,4-heptafluorobutyl) amine, F14NDBA were comparatively investigated for biological activity in two bacterial systems. Opposite orders of magnitude were obtained for their potency in the two tests. For inducing his+ reversion in auxotrophic strains of Salmonella typhimurium the sequence was F3NDBA greater than F6NDBA greater than NDBA and for inducing lethal DNA damage in repair deficient strains of Escherichia coli WP2 it was NDBA greater than F6NDBA. F14NDBA was not active in either test system.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004269:DNA, Bacterial / Q000378:metabolism; D004926:Escherichia coli / Q000235:genetics; D005461:Fluorine; D009152:Mutagenicity Tests; D009153:Mutagens; D009602:Nitrosamines / Q000633:toxicity*; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000235:genetics
D004269:DNA, Bacterial; D009153:Mutagens; D009602:Nitrosamines; D005461:Fluorine; C012279:dibutylnitrosamine; D003577:Cytochrome P-450 Enzyme System