Copper-zinc and manganese superoxide dismutase activities in cardiac and skeletal muscles during aging in male rats.
The activities of total superoxide dismutase (SOD) and the manganese (Mn SOD) and copper-zinc (Cu-Zn SOD) forms were determined in the supernatant fraction of heart, liver and six skeletal muscles from rats during aging. Total SOD activity increased in most muscles between 3 and 23 months of age. There was no change in activity in liver between 3 and 19 months of age. The increase in total activity in heart was due to increased Mn SOD activity, whereas increases in skeletal muscles were due to Cu-Zn SOD or to both Cu-Zn and Mn SOD. The nutritional implications during aging are discussed.
D000375:Aging; D000818:Animals; D008099:Liver / Q000201:enzymology / Q000502:physiology; D008297:Male; D009132:Muscles / Q000201:enzymology* / Q000502:physiology; D010210:Papillary Muscles / Q000201:enzymology / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D013482:Superoxide Dismutase / Q000378:metabolism*
D013482:Superoxide Dismutase