[Concentration of piperacillin in bone].
Eighteen patients received 2.0 grams of piperacillin sodium (PIPC) intravenously. The concentrations of PIPC in serum, cancellous bone, and cortical bone were measured approximately 30 minutes after injection. Serum concentrations ranged from 9.10 to 167.0 micrograms/ml (mean 95.61 +/- 10.03 micrograms/ml). Cortical bone concentrations varied between 0 and 17.5 micrograms/g (mean 4.58 +/- 1.03 micrograms/g). The levels measured in cancellous bone ranged from 0.62-13.1 micrograms/g (mean 8.07 +/- 1.43 micrograms/g). PIPC achieved high concentrations in bone.
D000368:Aged; D001842:Bone and Bones / Q000378:metabolism*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D010878:Piperacillin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
D010878:Piperacillin