title: ATP and the autonomy of the contractile vacuole in Amoeba proteus.
abstract: Contractile vacuole function in amoebae treated with immobilizing (5 mM) and nonimmobilizing (0.125 mM) concentrations of ATP has been studied. In ATP-immobilized amoebae, most vacuolar parameters are accelerated, especially the rate of output which passes from 30 to 70 micron3/sec. This favors the concept of an autonomous vacuole, fully functional in the absence of any bulk contribution to it from remote points of the cell. A lower concentration of ATP (0.125 mM), which does not inhibit movement, causes a still greater acceleration of vacuolar function. Work is in progress to elucidate the site and mode of action of exogenous ATP on Amoeba.
mesh_terms: D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000656:Amoeba / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D014617:Vacuoles / Q000187:drug effects
chemical_list: D000255:Adenosine Triphosphate