Coated vesicles of liver Golgi apparatus increased by ascorbate.
Cultured hepatocytes and hepatoma cells when treated for 10-30 min with 30 mM ascorbate (vitamin C) responded by a 2- to 3- fold increase in the numbers of coated vesicles of the Golgi apparatus zone as determined by quantitation from electron micrographs. At a near optimal concentration of 30 mM ascorbate, the effect was reproduced under a variety of conditions of fixation and methods of specimen preparation.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D002478:Cells, Cultured; D005333:Fetus; D006056:Golgi Apparatus / Q000187:drug effects / Q000648:ultrastructure*; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure*; D008114:Liver Neoplasms, Experimental / Q000648:ultrastructure*; D051381:Rats
D001205:Ascorbic Acid