[Results of a serological examination of amyotrophic lateral sclerosis patients].
Examinations of specimens from 12 patients with amyotrophic lateral sclerosis (ALS) by means of enzyme-labeled immunosorbent assay (ELISA) and solid-phase radioimmunoassay ( SPIRA ) demonstrated antibody to lymphocytic choriomeningitis virus (LCM) in the blood sera of 3 patients and antigens of LCM virus in sera of 2 other patients. LCM virus antigen was also found in organs of a patient who died of ALS. LCM virus was isolated from the serum of one patient positive for LCM antigen by inoculation of newborn white mice. The new isolate (the Kanta -220 strain) examined by electron microscope was shown to have some morphological differences from the museum strain CA-1371 of LCM virus available in the laboratory.
D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis* / Q000209:etiology / Q000382:microbiology; D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000032:analysis; D000956:Antigens, Viral / Q000032:analysis; D001921:Brain / Q000276:immunology / Q000382:microbiology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008217:Lymphocytic choriomeningitis virus / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity; D008297:Male; D051379:Mice; D008854:Microscopy, Electron; D008875:Middle Aged
D000914:Antibodies, Viral; D000956:Antigens, Viral
Rezul'taty serologicheskogo oblsedovaniia bol'nykh bokovym amiotroficheskim sklerozom.