[Radioprotective effectiveness of gas hypoxic mixture GHM-10 in experiments on dogs].
In experiments on 128 dogs (males and females) weighing 7-24 kg it was demonstrated that inhalation of gas hypoxic mixture containing O2 (10%) and N2 (90%) decreased significantly the level of PO2 in radiosensitive tissues and exerted a radioprotective effect on the exposed animals (60Co, doses of 2.8, 3.5-3.8 and 4.2 Gy, DMF = 1.3). At a dose of 8 Gy the average life of animals increased from 6.2 +/- 0.8 days (control) up to 9.3 +/- 1.1 days after the application of GHM -10.
D000818:Animals; D003037:Cobalt Radioisotopes / Q000008:administration & dosage; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D005260:Female; D008297:Male; D009584:Nitrogen / Q000494:pharmacology*; D010100:Oxygen / Q000032:analysis / Q000494:pharmacology*; D010313:Partial Pressure; D010758:Phosphorus / Q000032:analysis; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D011837:Radiation-Protective Agents
D003037:Cobalt Radioisotopes; D011837:Radiation-Protective Agents; D010758:Phosphorus; C041364:nitrox; D009584:Nitrogen; D010100:Oxygen
Radiozashchitnaia éffektivnost' gazovoĭ gipoksichesko smesi GGS-10 v opytakh na sobakakh.