Long persistence of doxorubicin in human skin after extravasation.
Extravasation of doxorubicin (DXR) from a dorsal hand vein is described. At 28 days following this event, high dermal concentrations of DXR were still present, not only at the injection site (1.7 X 10(-6) M X g-1) but also at a distance of 5 cm (0.4 X 10(-6) m X g-1. This long persistence of DXR in the skin necessitates ample excision of the skin following severe extravasation of the drug.
D000328:Adult; D004317:Doxorubicin / Q000008:administration & dosage / Q000009:adverse effects* / Q000032:analysis; D005260:Female; D006801:Humans; D007275:Injections, Intravenous / Q000009:adverse effects; D009336:Necrosis / Q000139:chemically induced; D012883:Skin Ulcer / Q000139:chemically induced* / Q000378:metabolism; D013997:Time Factors
D004317:Doxorubicin