Protection against paracetamol-induced hepatotoxicity by acetylsalicylic acid in rats.
Acetylsalicylic acid (ASA) given simultaneously with paracetamol decreased paracetamol-induced hepatotoxicity (measured by plasma transaminase activities as well as histology) without any effect on glutathione depletion, indicating that ASA prevents a process (or processes) subsequent to the metabolic activation of paracetamol. Delayed treatment with ASA also reduced paracetamol-induced liver toxicity, suggesting that reduction of the absorption rate of paracetamol does not contribute essentially to the protection by ASA. Combinations of paracetamol and ASA may have potential use in the development of safer analgesic combinations containing paracetamol (or ASA).
D000082:Acetaminophen / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations; D008099:Liver / Q000187:drug effects*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D000637:Transaminases / Q000097:blood
D004338:Drug Combinations; D000082:Acetaminophen; D000637:Transaminases; D001241:Aspirin