[Therapeutic effect of miconazole on fungal infection in patients with hematological malignancies].
The effectiveness of miconazole was evaluated in 9 documented fungal infections, 4 of which were candidal sepsis. All patients were receiving therapy for hematological malignancies. Miconazole revealed the excellent effect in 3 patients with candidal esophagitis and 1 patient with candidal sepsis and esophagitis. Twelve patients who received miconazole for presumed or documented fungal infection were evaluated for toxicity. No particular side effects, except for only 1 case of mild hepatic dysfunction, were observed. Miconazole is apparently an effective antifungal agents for treatment of systemic fungal infection in patients with hematological malignancies.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002177:Candidiasis / Q000188:drug therapy*; D004341:Drug Evaluation; D004941:Esophagitis / Q000188:drug therapy*; D005260:Female; D006689:Hodgkin Disease / Q000150:complications; D006801:Humans; D007938:Leukemia / Q000150:complications*; D008223:Lymphoma / Q000150:complications*; D008297:Male; D008825:Miconazole / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D018805:Sepsis / Q000188:drug therapy*
D008825:Miconazole