Synthesis and evaluation of N-alkanoyl-S-benzyl-L-cysteinylglutamic acid esters as glyoxalase I inhibitors and anticancer agents.
Esters of several glutathione analogues have been synthesized in which the glycine moiety was replaced by straight-chain fatty acids and the mercapto group was benzylated . Two of the derivatives (sufficiently water-soluble for the assay) were found to inhibit glyoxalase I to a greater extent than did S-methylglutathione. The two glyoxalase I inhibitors did not inhibit P388 lymphocytic leukemia in mice, however.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D005978:Glutathione / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D007791:Lactoylglutathione Lyase / Q000037:antagonists & inhibitors*; D007941:Leukemia P388 / Q000188:drug therapy; D008190:Lyases / Q000037:antagonists & inhibitors*; D051379:Mice
D000970:Antineoplastic Agents; D008190:Lyases; D007791:Lactoylglutathione Lyase; D005978:Glutathione