title: [Combined use of a specific vaccine and interferon inducers for preventing and treating experimental tick-borne encephalitis].
abstract: A comparative study of prophylactic and therapeutic activity of 6 Soviet interferon inducers in tick-borne encephalitis was carried out. Such inducers as double-stranded RNA, poly(G) . poly(C), and tyloron were most active prophylactically. A therapeutic effect was observed after combined use of specific vaccine and interferon inducers: double-stranded RNA and poly(G) . poly(C) which underwent clinical trials. When these inducers were administered 3 hours after infection the protective effect was 56.7% and 46%, respectively.
mesh_terms: D000818:Animals; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D004669:Encephalitis Viruses, Tick-Borne / Q000276:immunology*; D004675:Encephalitis, Tick-Borne / Q000517:prevention & control* / Q000628:therapy; D007369:Interferon Inducers / Q000008:administration & dosage*; D051379:Mice; D013997:Time Factors; D014765:Viral Vaccines / Q000008:administration & dosage*
chemical_list: D007369:Interferon Inducers; D014765:Viral Vaccines
vernacular_title: Sochetannoe primenenie spetsificheskoĭ vaktsiny i induktorov interferona dlia profilaktiki i lecheniia éksperimental'nogo kleshchevogo éntsefalita.