Experimental retinal detachment. VI. The permeability of the blood-retinal barrier.
Fluorophotometry was used to study the permeability of the blood-retinal barrier in six monkeys with stable rhegmatogenous retinal detachments. Fluorescein transport was inhibited by probenecid. The rate of fluorescein disappearance (KvVv) was determined following intravitreal injection. In a separate experiment the equilibrium vitreous-plasma concentration ratio (Cv/Cp) was determined following intraperitoneal administration. Expressed in equivalent volumes of vitreous, the rate of fluorescein diffusion across the blood-retinal barrier (K'vVvCv/Cp) was 0.29 microL/min in control eyes and 0.73 microL/min in detached eyes. The rate of fluid movement across the blood-retinal barrier (K'vVv) [1 - (Cv/Cp)] was 2.89 microL/min in control eyes and 6.38 microL/min in detached eyes. Posterior movement of fluid contributes to retinal apposition under normal conditions and accounts for the rapid resolution of retinal detachment following closure of the retinal hole.
D000818:Animals; D000867:Anterior Chamber / Q000378:metabolism; D002199:Capillary Permeability; D005260:Female; D019793:Fluorescein; D005452:Fluoresceins / Q000097:blood / Q000378:metabolism; D007700:Kinetics; D008252:Macaca fascicularis; D008297:Male; D008954:Models, Biological; D010539:Permeability; D011339:Probenecid / Q000494:pharmacology; D012160:Retina / Q000378:metabolism*; D012163:Retinal Detachment / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D012167:Retinal Perforations / Q000150:complications; D012171:Retinal Vessels / Q000378:metabolism; D014822:Vitreous Body / Q000378:metabolism
D005452:Fluoresceins; D011339:Probenecid; D019793:Fluorescein