title: [The nature of the so-called symptom-free periods of a disease].
abstract: The first structural changes in human diseases are the changes of cell membranes followed by their corresponding functional alterations (principle of the structure and function unity). In parallel with the destructive changes compensatory and adaptive processes (regenerative and hyperplastic) develop that level these changes and prevent homeostasis disorders. The higher is the host adaptive potential the longer clinical well-being can be retained in spite of the existing pathological process and the longer a patient with progressing morphological changes of a given organ is considered to be practically healthy. The first clinical symptoms of the disease appear when compensatory-adaptive reactions are not able to overmatch fully the organ destructive changes and resulting functional disorders. Therefore the preclinical period of the disease results in good compensation of morphological changes leading to the absence of the corresponding clinical symptoms.
mesh_terms: D000222:Adaptation, Physiological; D001669:Biochemical Phenomena; D001671:Biochemistry; D003289:Convalescence; D003933:Diagnosis; D004194:Disease / Q000209:etiology*; D006706:Homeostasis; D006801:Humans; D008854:Microscopy, Electron; D010336:Pathology
vernacular_title: O sushchnosti tak nazyvaemykh bessimptomnykh periodov bolezni.