Vitamin E attenuates the effects of FMLP on rabbit circulating granulocytes.
Exposure of circulating rabbit granulocytes to the chemoattractant N-formyl-methionyl-leucyl-phenylalanine (FMLP) in vivo results in transient granulocytopenia, hypotension, and cardiorespiratory distress. The effectiveness of vitamin E in attenuating these responses was tested. Vitamin E accelerated the rate of return of granulocytes to the peripheral circulation after FMLP-induced granulocytopenia and mitigated the hypotension. The reversible adherence of FMLP-stimulated granulocytes to endothelium offers a plausible mechanism to explain the transient granulocytopenia. From in vitro studies it was found that FMLP-activated granulocytes from animals treated with vitamin E showed decreased adherence to cultivated aortic endothelial monolayers when compared with FMLP-activated granulocytes from control animals.
D000380:Agranulocytosis / Q000139:chemically induced; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002448:Cell Adhesion / Q000187:drug effects; D006098:Granulocytes / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D007022:Hypotension / Q000139:chemically induced; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000037:antagonists & inhibitors* / Q000633:toxicity; D011817:Rabbits; D012119:Respiration / Q000187:drug effects; D012131:Respiratory Insufficiency / Q000139:chemically induced; D014810:Vitamin E / Q000494:pharmacology*
D014810:Vitamin E; D009240:N-Formylmethionine Leucyl-Phenylalanine