Phorbol myristate acetate inhibits immunoglobulin synthesis by human peripheral blood lymphocytes.
Phorbol myristate acetate (PMA), a known lymphocyte mitogen, has been shown to inhibit immunoglobulin synthesis by human peripheral blood lymphocytes. This effect occurs with low concentrations of the agent and following only 12 h contact with the lymphocytes. PMA was also capable of preventing pokeweed mitogen stimulation of lymphocytes. These experiments suggest that PMA prevents the complete differentiation of B-cells into plasma cells capable of secreting immunoglobulin.
D001402:B-Lymphocytes / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D006462:Hemolytic Plaque Technique; D007136:Immunoglobulins / Q000096:biosynthesis*; D007700:Kinetics; D008214:Lymphocytes / Q000378:metabolism*; D010704:Phorbols / Q000494:pharmacology*; D011043:Pokeweed Mitogens / Q000494:pharmacology; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*; D013997:Time Factors
D007136:Immunoglobulins; D010704:Phorbols; D011043:Pokeweed Mitogens; D013755:Tetradecanoylphorbol Acetate