Dantrolene sodium and dystrophia myotonica.
A patient with dystrophia myotonica was given dantrolene sodium to try to provide muscle relaxation during a cholecystectomy. Dantrolene was used as it is accepted that the drug has a place in the control of spasticity and also causes muscle relaxation, whereas conventional muscle relaxants are unable to control myotonia of muscle origin. Dantrolene alone did not provide good enough intubating and operating conditions in this subject. Later studies showed that, after dantrolene, EMG recordings from the patient were not significantly altered, although an impression of a slight increase in the myotonic potentials was gained.
D000328:Adult; D000768:Anesthesia, General; D002763:Cholecystectomy; D003620:Dantrolene / Q000494:pharmacology*; D004576:Electromyography; D006801:Humans; D008297:Male; D009132:Muscles / Q000187:drug effects; D009223:Myotonic Dystrophy / Q000503:physiopathology*
D003620:Dantrolene