IgM-RF prevents complement-mediated inhibition of immune precipitation.
Rheumatoid arthritis (RA) serum inhibits complement-mediated inhibition of immune precipitation (solubilization). We have isolated inhibitory activity from RA sera and shown that it is a property of IgM-rheumatoid factor (IgM-RF) and, to a lesser extent, IgG-RF.
D000936:Antigen-Antibody Complex / Q000378:metabolism*; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D011232:Chemical Precipitation; D003165:Complement System Proteins / Q000276:immunology*; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D012217:Rheumatoid Factor / Q000276:immunology*; D012995:Solubility
D000936:Antigen-Antibody Complex; D007075:Immunoglobulin M; D003165:Complement System Proteins; D012217:Rheumatoid Factor