Lowering of blood pressure in chronic aortic coarctate hypertensive rats with anti-digoxin antiserum.
A marked lowering of arterial blood pressure was observed in chronic aortic coarctate (CAC) hypertensive rats after intravenous administration of anti-digoxin antiserum. The hypotensive effect lasted for about 30 min after dosing. In contrast to the pronounced changes observed following treatment with anti-digoxin antiserum in CAC rats, only a transient pressor effect was observed in both water- and saline-drinking CAC rats following injection of normal goat serum. In addition, a transient depressor effect was observed in normotensive rats after injection of anti-digoxin antiserum. The results of this study provide additional evidence indicating that an endogenous digoxin-like substance may play an important role in the maintenance of chronic low-renin hypertension induced by aortic coarctation.
D000818:Animals; D001794:Blood Pressure; D004077:Digoxin / Q000276:immunology*; D004285:Dogs; D006041:Goats / Q000276:immunology; D006801:Humans; D006973:Hypertension / Q000628:therapy*; D007106:Immune Sera / Q000276:immunology; D007116:Immunization, Passive; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D007106:Immune Sera; D004077:Digoxin