Effect of three different dihydroxy bile acids on intestinal cholesterol absorption in normal volunteers.
Measurements of cholesterol absorption were performed by an intestinal perfusion technique before and after 4 wk of administration of three different dihydroxy bile acids [ursodeoxycholic acid (1 g/day), chenodeoxycholic acid (1 g/day), and deoxycholic acid (0.4 g/day)] in 6 normal volunteers. Mean hourly absorption of cholesterol declined from 41 mumol/h in the control period to 31 mumol/h (-22%) during feeding of chenodeoxycholic acid (NS). During deoxycholic acid administration, mean cholesterol absorption decreased from 46 to 28 mumol/h (-28%; p less than 0.05). Ursodeoxycholic acid feeding was associated with a reduction of cholesterol absorption from 38 to 13 mumol/h (-70%; p less than 0.05), even though the input of cholesterol from bile was reduced significantly (from 123 to 86 mumol/h). The results suggest that the hydroxy groups at different positions on the bile acid nucleus of these three dihydroxy bile acids differ in their potential for cholesterol absorption.
D000328:Adult; D002635:Chenodeoxycholic Acid / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism*; D003840:Deoxycholic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006801:Humans; D007408:Intestinal Absorption; D007413:Intestinal Mucosa / Q000378:metabolism*; D008875:Middle Aged; D013997:Time Factors; D014580:Ursodeoxycholic Acid / Q000494:pharmacology*
D003840:Deoxycholic Acid; D002635:Chenodeoxycholic Acid; D014580:Ursodeoxycholic Acid; D002784:Cholesterol