Malaria-induced immune thrombocytopenia.
On return from Liberia, a previously healthy 36-year-old man showed signs of malaria accompanied by severe haemolysis and slight thrombocytopenia. We found evidence of a platelet-associated IgG being responsible for the thrombocytopenia, inasmuch as the direct platelet suspension immunofluorescence test was strongly positive, the indirect immunofluorescence test and tests for drug-dependent antibodies at the same time being negative. We suggest that autoimmunity may be a contributing mechanism for platelet destruction in acute malaria.
D000328:Adult; D001323:Autoantibodies; D001792:Blood Platelets / Q000276:immunology; D006461:Hemolysis; D006801:Humans; D007074:Immunoglobulin G; D008288:Malaria / Q000097:blood / Q000150:complications* / Q000276:immunology; D008297:Male; D013921:Thrombocytopenia / Q000097:blood / Q000209:etiology* / Q000276:immunology
D001323:Autoantibodies; D007074:Immunoglobulin G