[Whole-skin electron therapy: a therapeutic concept for mycosis fungoides and Sézary syndrome. 2: Therapy].
The alterations of mycosis fungoides of a malignant T-cell lymphoma are extremely radiosensitive. In the treatment of the cutaneous manifestation of mycosis fungoides, the whole-skin electron therapy is superior to the superficial application of mechlorethamine (NH2), to photochemotherapy with psoralen and ultraviolet radiation as well as to chemotherapy as monotherapy and combined therapy. Complete remissions are to be expected in 93% of all cases after application of a high total dose of more than 30 Gy. After less than 10 Gy, this rate is 18%. A combination of whole-skin electron therapy (30 Gy) with chemotherapy or with a total lymphoid irradiation with 30 Gy represents a new approach for the treatment of advanced tumor stages.
D000328:Adult; D000367:Age Factors; D004583:Electrons; D006801:Humans; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000401:mortality / Q000532:radiotherapy*; D009367:Neoplasm Staging; D011836:Radiation Tolerance; D011879:Radiotherapy Dosage; D012751:Sezary Syndrome / Q000532:radiotherapy*; D012867:Skin / Q000528:radiation effects
Ganzhaut-Elektronentherapie: ein Therapiekonzept bei Mycosis fungoides und Sézary-Syndrom. 2. Teil: Therapie.