[Effect of bombesin, its various fragments and their analogs on thermoregulation in rabbits].
Out of synthetic tetradecapeptide bombesin, its fragments C-terminal nonapeptide and N-terminal pentapeptide and their analogues ( Val7 , D- Ala11 ), ( Ala7 , D- Ala11 ), (Leu7, D- Ala11 ) and ( Pro6 , Gly7 , D- Ala11 ), the first two, being injected into the lateral ventricle of the brain in rabbits, affected the body temperature in cold environment (+ 10 degrees C). The analogues exerted a lesser effect on the body temperature. N-terminal pentapeptide was ineffective both in cold (+ 10 degrees C) and warm (+ 30 degrees C) environment.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D001839:Bombesin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology*; D007035:Hypothermia / Q000139:chemically induced; D007276:Injections, Intraventricular; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D010455:Peptides / Q000494:pharmacology*; D011817:Rabbits
D010446:Peptide Fragments; D010455:Peptides; C030475:bombesin nonapeptide; D001839:Bombesin
Vliianie bombezina, nekotorykh ego fragmentov i ikh analogov na termoreguliatsiiu krolika.