title: Methylation of the O6 position of guanine in DNA is the most likely initiating event in carcinogenesis by methylating agents.
mesh_terms: D000477:Alkylating Agents / Q000633:toxicity*; D000818:Animals; D002273:Carcinogens; D002471:Cell Transformation, Neoplastic; D004247:DNA / Q000378:metabolism*; D006147:Guanine / Q000031:analogs & derivatives* / Q000032:analysis; D006801:Humans; D008099:Liver / Q000378:metabolism; D008745:Methylation; D008780:Methyltransferases / Q000378:metabolism; D009369:Neoplasms / Q000139:chemically induced*; D019853:O(6)-Methylguanine-DNA Methyltransferase; D011743:Pyrimidines / Q000032:analysis; D013329:Structure-Activity Relationship
chemical_list: D000477:Alkylating Agents; D002273:Carcinogens; D011743:Pyrimidines; D006147:Guanine; D004247:DNA; C008449:O-(6)-methylguanine; D008780:Methyltransferases; D019853:O(6)-Methylguanine-DNA Methyltransferase