title: Analysis of circadian rhythms by fitting a least squares sine curve.
abstract: A method that fits a least squares sine curve to both point and averaged time series data is described. The method includes a full regression analysis and extends the current "cosinor" approach. Developments include estimation of the linear trend and fitting secondary wave forms.
mesh_terms: D000368:Aged; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D011188:Potassium / Q000652:urine; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D011188:Potassium