title: Immunoreactive parathyroid hormone, calcium, and magnesium in human cerebrospinal fluid.
abstract: Parathyroid hormone (PTH) was measured radioimmunologically in simultaneous plasma and cerebrospinal fluid (CSF) samples obtained from 72 patients aged 20 to 80 years without endocrine or psychiatric diseases and from 2 patients aged 40 and 70 years with secondary hyperparathyroidism due to renal insufficiency. They underwent routine diagnostic lumbar puncture because of suspected prolapse of a disc. Total calcium (Ca) and magnesium (Mg) were also determined in these samples by complexometry . The following findings were obtained (ng/ml, median, range in brackets): Plasma PTH 1.7 (0.7-6.6); CSF PTH 0.8 (0.5-2.3), respectively. No correlation was found between PTH concentrations in plasma and CSF in all 74 samples. The Ca concentrations in plasma, with a median of 2.3 mmol/l (2.1-2.6) were significantly higher than the Ca concentrations in CSF (median 1.1 mmol/l, range 0.4-1.3). The correlation between PTH and calcium levels in CSF was only weak (r = 0.284 P less than 0.05). The Mg levels in CSF (median 1.1 mmol/l, range 0.7-1.6) were higher than Mg concentrations in plasma (median 0.9 mmol/l, range 0.6-1.1). No correlation was found between PTH and Mg in CSF. Our study demonstrated that in man PTH is a normal constituent of CSF.
mesh_terms: D000328:Adult; D000368:Aged; D002118:Calcium / Q000097:blood / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D006961:Hyperparathyroidism / Q000378:metabolism; D007405:Intervertebral Disc Displacement / Q000378:metabolism; D007525:Isoelectric Focusing; D008159:Lumbar Vertebrae; D008274:Magnesium / Q000097:blood / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood / Q000134:cerebrospinal fluid*; D011863:Radioimmunoassay
chemical_list: D010281:Parathyroid Hormone; D008274:Magnesium; D002118:Calcium