Incorporation of 15N from glycine into uric acid in gout: a follow-up study.
Over-incorporation of 15N-labeled glycine into uric acid indicates over-production of uric acid by de novo purine biosynthesis. This metabolic aberration, though considered to be inborn (3), may be modified by changing of life style, aging and long-term therapy. In the patient under study, the protracted use of allopurinol seems to have played the most important role. Aging contributed to a certain extent, and changing life style was the least significant factor.
D000328:Adult; D005500:Follow-Up Studies; D005998:Glycine / Q000378:metabolism*; D006073:Gout / Q000378:metabolism*; D006801:Humans; D008297:Male; D009587:Nitrogen Isotopes; D014527:Uric Acid / Q000096:biosynthesis*
D009587:Nitrogen Isotopes; D014527:Uric Acid; D005998:Glycine