Increased concentrations of immunoreactive leukotrienes in cutaneous lesions of eosinophilic cellulitis.
A case of eosinophilic cellulitis is described. Tests of eosinophil function were normal. Radioimmunoassay identification of inflammatory mediators showed greatly increased concentrations of leukotrienes LTC4/D4 (components of slow-reacting substance of anaphylaxis) in the affected skin. These mediators may play a causal role in the inflammation seen with eosinophilic cellulitis.
D000328:Adult; D002481:Cellulitis / Q000378:metabolism*; D004802:Eosinophilia / Q000378:metabolism*; D005122:Exudates and Transudates / Q000032:analysis; D006801:Humans; D008297:Male; D011863:Radioimmunoassay; D013189:SRS-A / Q000032:analysis*; D012867:Skin / Q000032:analysis*
D013189:SRS-A