A radiopharmacological study without human radiation exposure.
The development, study and control of new drugs today is hardly conceivable without nuclear medicine studies. Nuclear physicians on ethical commissions bear great responsibility in the planning and execution of such studies. In order to protect subjects and patients those nuclear techniques are therefore to be welcome which do not include exposure to radiation. Nuclear techniques used in in-vitro diagnostics (RIA) and the determination of naturally occurring nuclides incorporated in the human body belong to this category. With the aid of a clinico-pharmacological study of a new combination of diuretics it is shown that both methods supply valuable pharmacodynamic evidence.
D000284:Administration, Oral; D000328:Adult; D000450:Aldosterone / Q000097:blood; D004307:Dose-Response Relationship, Radiation; D004359:Drug Therapy, Combination; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011188:Potassium / Q000097:blood; D011835:Radiation Protection; D011863:Radioimmunoassay; D012084:Renin-Angiotensin System / Q000187:drug effects; D013054:Spectrophotometry, Atomic; D014223:Triamterene / Q000494:pharmacology*
D000450:Aldosterone; D005665:Furosemide; D011188:Potassium; D014223:Triamterene