title: The gastric mucosal barrier: structure of intercellular junctions in the dog.
abstract: The canine gastric mucosa consists of two regions, the surface mucous cells and gland area cells including parietal, chief, and mucous-containing cells. We have used quantitative freeze-fracture methods in conjunction with thin-section extracellular tracers to document and correlate tight junction morphology with epithelial permeability. The number of strands in the tight junction complexes of the surface cells and gland cells is the same, but differences in strand arrangement exist. The surface cells have an interwoven tight junction configuration which is impermeable to extracellular tracers. The gland cell junctions are regularly arranged and often permeable to extracellular lanthanum. The possibility that the observed difference in permeability between the tight junctions of the surface mucous cells and those of the gland cells is related to their structural configuration is discussed.
mesh_terms: D000818:Animals; D002463:Cell Membrane Permeability; D004285:Dogs; D005260:Female; D005614:Freeze Fracturing; D005753:Gastric Mucosa / Q000648:ultrastructure*; D006735:Horseradish Peroxidase; D007365:Intercellular Junctions / Q000648:ultrastructure*; D007811:Lanthanum; D008297:Male
chemical_list: D007811:Lanthanum; D006735:Horseradish Peroxidase