Iron deficiency in the rat: effects on oxidative metabolism in distinct types of skeletal muscle.
Studies performed on iron-deficient and control rats demonstrated that oxidative energy production (phosphorylation) by mitochondria from iron-deficient red and intermediate skeletal muscles was greatly reduced with pyruvate-malate, succinate, and alpha-glycerophosphate as substrates. Although phosphorylation was also decreased in iron-deficient white skeletal muscle with succinate and pyruvate-malate as substrates, no change was found with alpha-glycerophosphate as substrate.
D000747:Anemia, Hypochromic / Q000378:metabolism*; D000818:Animals; D005994:Glycerophosphates; D008293:Malates; D008297:Male; D008931:Mitochondria, Muscle / Q000201:enzymology; D009132:Muscles / Q000378:metabolism*; D010085:Oxidative Phosphorylation; D010088:Oxidoreductases / Q000378:metabolism; D011773:Pyruvates; D019289:Pyruvic Acid; D051381:Rats; D011919:Rats, Inbred Strains; D013386:Succinates
D005994:Glycerophosphates; D008293:Malates; D011773:Pyruvates; D013386:Succinates; D019289:Pyruvic Acid; C029620:alpha-glycerophosphoric acid; D010088:Oxidoreductases