[Methodologic approach to individual evaluation of the pharmacodynamic effects of single doses of hydralazine, endralazine, prazosine and propranolol in hypertension patients].
The possibility to apply impedance cardiography technique and individual statistical analysis based on Dixon's criterion to pharmacodynamic studies of single hydralazine ( apressine ), prazosine ( pratsiol ), endralazine ( mirethilan ), propranolol (obsidan) doses is discussed. 12 patients with essential hypertension, stage II were examined. Blood pressure was measured by the method of Korotkov , heart volume and total peripheral vascular resistance were determined by impedance cardiography. Apressin , mirethilan , pratsiol and obsidan doses were 50-100 mg, 5-15 mg, 2-5 mg and 80-120 mg, respectively. The drug effect was compared with that of placebo. Impedance cardiography in combination with the method of Korotkov were shown to be appropriate for recording qualitative alterations of hemodynamic parameters during pharmacodynamic studies of single apressine , mirethilan , pratsiol an obsidan doses. The data obtained allow objective individual assessment of single dose efficacy based on Dixon's criterion.
D000328:Adult; D000959:Antihypertensive Agents / Q000008:administration & dosage*; D002302:Cardiac Output; D002307:Cardiography, Impedance; D006801:Humans; D006830:Hydralazine / Q000008:administration & dosage; D006973:Hypertension / Q000188:drug therapy*; D007700:Kinetics; D008875:Middle Aged; D011224:Prazosin / Q000008:administration & dosage; D011433:Propranolol / Q000008:administration & dosage; D011724:Pyridazines / Q000008:administration & dosage; D014655:Vascular Resistance
D000959:Antihypertensive Agents; D011724:Pyridazines; D006830:Hydralazine; C014926:BQ 22-708; D011433:Propranolol; D011224:Prazosin
Metodicheskiĭ podkhod k individual'noĭ otsenke farmakodinamicheskogo éffekta odnokratnykh doz gidralazina, endralazina, prazozina, propranolola u bol'nykh gipertonicheskoĭ bolezn'iu.