Effects of enfenamic acid on renal electrolyte excretion in hypertensive patients.
Single and multiple doses of enfenamic acid were compared in hypertensive patients with those of hydrochlorothiazide using urinary output and electrolytes as parameters. With enfenamic acid, excretion of Na+, K+, and Cl- was significantly decreased in the multiple-dose study; after single doses, there was a significant decrease in the excretion of Na+ and Cl- only.
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004573:Electrolytes / Q000652:urine*; D006801:Humans; D006852:Hydrochlorothiazide / Q000494:pharmacology; D006973:Hypertension / Q000652:urine*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D004573:Electrolytes; D062367:ortho-Aminobenzoates; C019126:enfenamic acid; D006852:Hydrochlorothiazide; D012964:Sodium; D011188:Potassium