title: Role of right atrial receptors in the control of drinking in the rat.
abstract: Balloons were implanted at the junction of the superior vena cava and right atrium of the rat. Inflation of the balloon stretched the vein-atrial junction but did not cause a change in either arterial or central venous blood pressure. Inflating the balloon attenuated spontaneous night-time water intake and the drinking responses to 24 h water deprivation and subcutaneous (s.c.) isoprenaline (10 micrograms/kg body wt.). Water intake after I.P. hyperoncotic colloid (polyethylene glycol 20 M) was virtually abolished when the balloon was inflated immediately before giving access to water (4 h after injection). Inflating the balloon had no effect on drinking following I.V. hypertonic saline (5 ml 2M-NaCl/kg body wt.). These results support the hypothesis that volume receptors on the right side of the heart are involved in controlling water intake.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D003102:Colloids; D004326:Drinking / Q000187:drug effects; D006321:Heart / Q000294:innervation*; D006325:Heart Atria / Q000294:innervation; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D011092:Polyethylene Glycols / Q000494:pharmacology; D011311:Pressoreceptors / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012462:Saline Solution, Hypertonic / Q000494:pharmacology; D014683:Vena Cava, Superior / Q000294:innervation; D014868:Water Deprivation
chemical_list: D003102:Colloids; D012462:Saline Solution, Hypertonic; D011092:Polyethylene Glycols; D007545:Isoproterenol