Y-encoded, species-specific DNA in mice: evidence that the Y chromosome exists in two polymorphic forms in inbred strains.
We have investigated the structure of the murine Y chromosome by first developing a novel method for specifically cloning Y-encoded DNA and then generating a library enriched for Y-specific DNA sequences. Three randomly chosen Y DNA clones were studied and found to share several interesting properties: all three are members of small Y-specific multisequence families; all three are mouse-specific; and all three probes detect Y-encoded restriction fragments that are polymorphic. Examination of polymorphic Y chromosome restriction fragments in male DNA from nine different inbred strains suggests that only two polymorphic forms of Y chromosomal DNA exist among inbred strains of mice.
D000818:Animals; D002645:Chickens; D004247:DNA / Q000235:genetics*; D005260:Female; D006801:Humans; D008099:Liver / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D009693:Nucleic Acid Hybridization; D011110:Polymorphism, Genetic; D051381:Rats; D013045:Species Specificity; D014998:Y Chromosome / Q000502:physiology*
D004247:DNA