title: Evidence for a spinal afferent innervation of the guinea pig lower respiratory tract as studied by the horseradish peroxidase technique.
abstract: The afferent innervation of the guinea pig lower respiratory tract was studied using a retrograde axonal transport technique with application of horseradish peroxidase (HRP) onto the lining respiratory epithelium. HRP-labeled cells were observed not only in the nodose ganglia but also in the jugular and upper thoracic dorsal root ganglia (mainly at the T2-T3 levels). Thus, both vagal parasympathetic and spinal sympathetic afferents seem to have peripheral branches close to or within the respiratory epithelium suggesting a dual sensory control of the airways.
mesh_terms: D000344:Afferent Pathways / Q000033:anatomy & histology; D000818:Animals; D001980:Bronchi / Q000294:innervation; D004848:Epithelium / Q000033:anatomy & histology; D005727:Ganglia, Spinal / Q000033:anatomy & histology; D005728:Ganglia, Sympathetic / Q000033:anatomy & histology; D006168:Guinea Pigs; D006735:Horseradish Peroxidase; D008168:Lung / Q000294:innervation*; D008297:Male; D009620:Nodose Ganglion / Q000033:anatomy & histology; D013116:Spinal Cord / Q000033:anatomy & histology*; D013564:Sympathetic Nervous System / Q000033:anatomy & histology; D014630:Vagus Nerve / Q000033:anatomy & histology
chemical_list: D006735:Horseradish Peroxidase