Differential effects of surgical suture materials in 1,2-dimethylhydrazine-induced rat intestinal neoplasia.
The incidence, distribution, size, and histopathology of rat small and large bowel tumors induced by sequential administration of 1,2-dimethylhydrazine followed by cecal placement of one of six differing types of suture materials were systematically examined. In addition, measurements of beta-glucuronidase activities in large bowel contents followed by fecal trace metal determinations were done. The results indicate that specific slowly absorbed and nonabsorbable suture materials in the absence of a surgical anastomosis promote tumor induction locally in the rat cecum. In addition, cecal suture material composed of multifilament stainless steel wire enhanced tumor development at a "downstream" site in the distal colon, paralleling increased fecal beta-glucuronidase activities at this site and implicating a possible luminally mediated mechanism for colon tumor development in this animal model.
D000818:Animals; D002430:Cecal Neoplasms / Q000473:pathology / Q000503:physiopathology*; D002432:Cecum / Q000187:drug effects / Q000201:enzymology; D002857:Chromium / Q000032:analysis; D003106:Colon / Q000187:drug effects / Q000201:enzymology; D003110:Colonic Neoplasms / Q000473:pathology / Q000503:physiopathology*; D004127:Dimethylhydrazines; D005243:Feces / Q000032:analysis; D005966:Glucuronidase / Q000378:metabolism; D007501:Iron / Q000032:analysis; D008297:Male; D011108:Polymers / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013537:Sutures
D004127:Dimethylhydrazines; D011108:Polymers; D002857:Chromium; D007501:Iron; D005966:Glucuronidase