Penicillamine metal chelates and their possible importance in rheumatoid arthritis--a brief review.
Complexes formed between penicillamine and metal ions have in vitro effects that may have implications regarding the therapeutic action of D-penicillamine in rheumatoid arthritis. Penicillamine-copper (I) complexes suppress arthritis in animal models and suppress or inhibit mediators of inflammation such as lysosomal enzymes, prostaglandins and the oxidative metabolites of the respiratory burst; whether the inhibition of certain in vitro immunologic responses by the same complexes has any in vivo significance remains to be determined.
D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy*; D002614:Chelating Agents / Q000627:therapeutic use*; D003300:Copper / Q000097:blood / Q000627:therapeutic use*; D006046:Gold / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D008657:Metabolic Clearance Rate; D010396:Penicillamine / Q000097:blood / Q000627:therapeutic use*
D002614:Chelating Agents; D006046:Gold; D003300:Copper; D010396:Penicillamine