The short-term effects of reducing elevated blood pressure in elderly patients with propranolol and dyazide.
Propranolol and Dyazide (25 mg hydrochlorothiazide and 50 mg triamterene) were used singly to reduce the elevated blood pressure (systolic ranging from 170 to 271 mmHg and diastolic ranging from 100 to 141 mmHg) of 38 elderly hypertensive patients whose ages ranged from 69 to 91 years. Each compound was administered for a period of four weeks with a wash-out period of four weeks in between. The following parameters were assessed before and after each treatment period: cerebral blood flow (CBF), mental functions, cardiac output (CO), electrocardiogram, glomerular filtration rate (GFR) and serum biochemistry. Both systolic and diastolic blood pressure were significantly reduced following the administration of either compound. No significant change in CBF and CO could be observed after reducing the blood pressure whether Propranolol or Dyazide was used. The GFR was, however, significantly reduced and the plasma creatinine significantly increased following Dyazide but not Propranolol administration. As expected the administration of the latter compound was associated with a significant bradycardia. No significant change could be observed in the other parameters studied.
D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects*; D002302:Cardiac Output / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects; D003071:Cognition / Q000187:drug effects; D004338:Drug Combinations / Q000627:therapeutic use; D004562:Electrocardiography; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D011433:Propranolol / Q000627:therapeutic use*; D014223:Triamterene / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D004338:Drug Combinations; D006852:Hydrochlorothiazide; C020743:hydrochlorothiazide-triamterene; D011433:Propranolol; D014223:Triamterene