Inability of the mutagen-blocking agent oleic acid to protect against colon carcinogenesis in the rat.
Oleic acid has been found in cooked beef and human feces. It has also been found to protect against mutagenesis as measured by the Salmonella microsomal assay test. Addition of oleic acid to the diet of rats treated with 1,2-dimethylhydrazine, a colon carcinogen, failed to protect the rats against the induction of colon cancer.
D019813:1,2-Dimethylhydrazine; D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D003110:Colonic Neoplasms / Q000139:chemically induced* / Q000517:prevention & control; D004127:Dimethylhydrazines / Q000633:toxicity; D008297:Male; D019301:Oleic Acid; D009829:Oleic Acids / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; D004127:Dimethylhydrazines; D009829:Oleic Acids; D019301:Oleic Acid; D019813:1,2-Dimethylhydrazine