[Carcinoma of the colon associated with diffuse metastatic leptomeningeal carcinomatosis (DMLC) presenting as disturbance of consciousness--a case report].
A 58-year-old man was admitted to Saiseikai Hospital complaining of vertigo and visual acuity disturbance. His admission physical examination was unremarkable; his spinal fluid contained 69 large mononuclear cells/mm3. Cytological examination was not done. His disturbance of consciousness rapidly progressed to coma and he died on the 10 th hospital day. At autopsy, Borrmann Type II carcinoma (3 cm in diameter) was found in the cecum. Microscopical examination revealed that the tumor was a poorly differentiated adenocarcinoma. Diffuse metastasis was found in the leptomeningium , but there was no evidence of metastasis to other organ.
D000230:Adenocarcinoma / Q000150:complications / Q000473:pathology / Q000556:secondary*; D001063:Appendiceal Neoplasms / Q000473:pathology*; D001099:Arachnoid; D001932:Brain Neoplasms / Q000150:complications / Q000473:pathology / Q000556:secondary*; D003072:Cognition Disorders / Q000209:etiology*; D003244:Consciousness Disorders / Q000209:etiology*; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008577:Meningeal Neoplasms / Q000150:complications / Q000473:pathology / Q000556:secondary*; D008875:Middle Aged; D010841:Pia Mater