Rapid onset of an increase in caffeine residence time in young women due to oral contraceptive steroids.
Oral contraceptive steroids increased the residence time of caffeine in 9 young women by a factor of 2. The effect was already manifested during the first cycle 2 weeks after starting oral contraceptive steroids (OCS) and was slightly increased in the second cycle, after 6 weeks on OCS. Toxic effects attributed to oral contraceptive steroids may in part be indirect and due to prolonged retention of absorbed toxic agents to which women are exposed.
D000293:Adolescent; D000328:Adult; D002110:Caffeine / Q000097:blood*; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics
D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D002110:Caffeine