[The effect of Chinese drug therapy on the patients with male infertility. 1. Concomitant administration of ninjinto and hachimijiogan on patients with male infertility].
Ten patients (age range, 28 to 36 years with a mean of 32.3 years) with male infertility were orally given Ninjinto and Hachimijiogan concomitantly at a daily dose of 7.5 g each for 96 to 182 days (mean 116.8 days). Ten percent of these patients showed remarkable improvement in their volume of semen, 10% showed improvement and 80.0% showed no improvement. Thirty percent of these patients showed remarkable improvement in the number of sperm, 10.0% showed improvement, and 60.0% showed no improvement. Twenty percent of these patients showed remarkable improvement in their sperm mobility, 30.0% showed improvement and 50.0% showed no improvement. The fertility index was improved markedly in 60.0%, improved in 20.0% and not improved in 20.0%. The spouses of 2 patients became pregnant. Side effects were seen in only 30.0% (epigastralgia) of these patients. Laboratory examination of these patients revealed no significant change. These results suggested that concomitant administration of Ninjinto and Hachimijiogan is effective on patients with male infertility.
D000328:Adult; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005298:Fertility; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008516:Medicine, Chinese Traditional; D008518:Medicine, East Asian Traditional; D010946:Plants, Medicinal; D013076:Sperm Count; D013081:Sperm Motility