title: [Hypothesis of the pathogenesis of renoparenchymal hypertension in chronic kidney failure patients before starting treatment with periodic hemodialysis].
abstract: After a brief presentation of the pathogenetic scheme of renoparenchymal hypertension (RPH) in acute glomerulonephritis, of the pathogenesis of not controlled by dialysis and renin-dependent RPH, as well as of the more important causes for origination of arterial hypertension in patients with transplanted kidney, the author suggests the hypothesis, that the RPH in patients with ChRI , prior to the inclusion of the chroniodialysis treatment, originates, is maintained and becomes more frequent and graver , very likely, due to the gradual and progressive accumulation of factors within the patient's organism, elevating the arterial pressure, either by their reduced excretion through the affected kidneys or due to their increased production. In the development of the hypothesis, the author is based on some well known facts from literature and on his own studies, as elevated level of catecholamines in myocardium of patients that died with uremia, decreased elimination of catecholamines in patients with ChRI , elevated level of plasma cortisol in patients with chronic glomerular nephritis and ChRI , elevated levels of somatotropic and of thyreotropic hormone in patients with ChRI , elevated levels of angiotension 2 and of plasma aldosterone in some of the patients with RPH and ChRI , enhanced tendency to sodium and water retention in patients with ChRI , a tendency to increased volume of circulating plasma, increased stroke volume, increased general peripheral resistance, tendency to acidosis and to elevation of the serum level of potassium in advanced ChRI .
mesh_terms: D006801:Humans; D006977:Hypertension, Renal / Q000209:etiology* / Q000503:physiopathology / Q000628:therapy; D007668:Kidney / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D006435:Renal Dialysis; D014511:Uremia / Q000503:physiopathology
vernacular_title: Khipoteza za patogenezata na renoparenkhimnata khipertoniia pri bolni s khronichna bŭbrechna nedostatŭchnost predi zapochvane na lechenieto s periodichna khemodializa.