Linkage of genes for human esterase D and hereditary retinoblastoma.
Determinations of esterase D isoenzymes in the members of a family with hereditary retinoblastoma gave results consistent with linkage between the loci for esterase D and retinoblastoma. This gene linkage allows the detection of gene carrier states in certain kindreds. We used this technique to predict that a 6-month-old boy carries the tumor-predisposing retinoblastoma gene.
D000328:Adult; D000483:Alleles; D043182:Carboxylesterase; D002265:Carboxylic Ester Hydrolases / Q000235:genetics*; D002874:Chromosome Mapping; D005134:Eye Neoplasms / Q000235:genetics*; D005260:Female; D006580:Genetic Carrier Screening; D008040:Genetic Linkage; D006801:Humans; D007223:Infant; D007527:Isoenzymes / Q000235:genetics*; D008297:Male; D010375:Pedigree; D011995:Recombination, Genetic; D012175:Retinoblastoma / Q000235:genetics*
D007527:Isoenzymes; D002265:Carboxylic Ester Hydrolases; D043182:Carboxylesterase; C020118:ESD protein, human