title: Dermal lipofuscinosis associated with amiodarone therapy. Report of a case.
abstract: Amiodarone hydrochloride is a noncompetitive adrenergic blocker used in the treatment of tachyarrhythmias. Its use in Europe and South America has been associated with cutaneous pigmentation thought to be caused by lipofuscin deposition in the dermis. We describe a similar case occurring in North America. A skin biopsy specimen from the patient was examined by light microscopy, fluorescence microscopy, and electron microscopy. From these examinations, a diagnosis of dermal lipofuscinosis was made.
mesh_terms: D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D001572:Benzofurans / Q000009:adverse effects*; D005148:Facial Dermatoses / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008062:Lipofuscin / Q000378:metabolism*; D008297:Male; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000473:pathology; D010860:Pigments, Biological / Q000378:metabolism*; D012867:Skin / Q000648:ultrastructure
chemical_list: D001572:Benzofurans; D008062:Lipofuscin; D010860:Pigments, Biological; D000638:Amiodarone