Alterations in leukocyte aryl hydrocarbon hydroxylase activity associated with treatment and age in psoriasis patients and healthy individuals.
We have examined the relationship between topical psoriasis treatment and the activity of the mixed function oxidase, aryl hydrocarbon hydroxylase (AHH), in peripheral blood monocytes and lymphocytes from 20 patients with psoriasis. These data were compared to monocyte and lymphocyte AHH activity measured in 20 normal subjects. AHH activity was determined in cells induced with benzanthracene and in uninduced control cells. Monocyte and lymphocyte AHH activity in six untreated psoriasis patients was similar to that in the healthy controls. AHH activity in either uninduced or induced monocytes showed an increase with age in both the healthy and the untreated psoriatic subjects. Lymphocytes from the healthy subjects showed an age-related decline in enzyme activity. Fourteen patients with psoriasis receiving topical tar and/or topical corticosteroid therapy had significantly higher (P less than 0.05) levels of basal and induced monocyte and lymphocyte AHH activity than the healthy controls. AHH activity is age-related and appears to be controlled differently in monocytes and in lymphocytes. AHH activity in circulating monocytes and lymphocytes may be stimulated by topical tar and/or steroid therapy of psoriasis.
D000287:Administration, Topical; D000305:Adrenal Cortex Hormones / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D001189:Aryl Hydrocarbon Hydroxylases / Q000097:blood*; D003033:Coal Tar / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000188:drug therapy* / Q000201:enzymology
D000305:Adrenal Cortex Hormones; D003033:Coal Tar; D001189:Aryl Hydrocarbon Hydroxylases