Inhibition by verapamil of ischemic Ca2+ uptake in the rabbit hippocampus.
In the study described here a perfusion-dialysis system was used for recording ionic changes in the hippocampus during ischemia. Local perfusion with a Ca2+ entry blocker (verapamil) inhibited the fall in extracellular Ca2+ concentration which occurs in ischemia. The data consequently suggest that intracellular Ca2+ accumulation during ischemia can be blocked. A Ca2+ antagonist such as verapamil may thus improve post-ischemic neuronal recovery via a direct effect on parenchymal cells in addition to the previously suggested vascular effects.
D000818:Animals; D001921:Brain / Q000378:metabolism; D002545:Brain Ischemia / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D008297:Male; D011817:Rabbits; D014700:Verapamil / Q000494:pharmacology*
D014700:Verapamil; D002118:Calcium