[Effect of isopropylnoradrenaline included in liposomes on cardiac hemodynamics during the adrenoreceptor blockade].
Isopropylnoradrenaline (INA) included in liposomes caused positive inotropic and system depression effects in cats. Duration of the reaction increased by 3.5 times compared with the response to a free form of beta-adrenomimetic. It was shown that the liposome beta-adrenomimetic induced a cardiostimulating effect under blockade of adrenergic receptors and increased the arterial blood pressure in this condition. Administration of INA after liposomes increased the arterial blood pressure as well. The data obtained suggest that the specific character of adrenergic receptors can be altered with exogenous phospholipids.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002316:Cardiotonic Agents; D002415:Cats; D004338:Drug Combinations; D006439:Hemodynamics / Q000187:drug effects*; D007545:Isoproterenol / Q000008:administration & dosage* / Q000494:pharmacology; D008081:Liposomes / Q000008:administration & dosage*; D009200:Myocardial Contraction / Q000187:drug effects*; D010646:Phentolamine / Q000008:administration & dosage*; D011433:Propranolol / Q000008:administration & dosage*; D013268:Stimulation, Chemical; D014655:Vascular Resistance / Q000187:drug effects
D002316:Cardiotonic Agents; D004338:Drug Combinations; D008081:Liposomes; D011433:Propranolol; D007545:Isoproterenol; D010646:Phentolamine
Vliianie zakliuchennogo v liposomy izopropilnoradrenalina na kardiogemodinamiku v usloviiakh blokady adrenoretseptorov.