[Evaluation of activity and the electron microscope picture in Paget's disease].
Thirteen patients with Paget's disease followed-up for prolonged periods of time were subjected to a series of biological tests and to studies of radionuclides incorporation into skeletal tissues. Bone alkaline phosphatase showed an osteoblastic activity, and tartarate -resistant acid phosphatases an osteoclastic function. Hydroxyproline in urine corresponded to the osteoclastic destruction. The X-ray pattern did not agree necessarily with the local metabolic bone activity of phosphates ( 99mTechnetium pyrophosphate), or of glycoproteins (85Sr). The use of scanning was recommended for studies of local activity and to correlate the results obtained with the clinical and biochemical syndromology . The electronoptic pattern was similar to that observed in inclusions of the paramyxovirus or papova virus. The problems associated with the differential diagnosis were discussed.
D000328:Adult; D000368:Aged; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D010001:Osteitis Deformans / Q000378:metabolism / Q000473:pathology*; D010006:Osteoblasts / Q000648:ultrastructure; D010010:Osteoclasts / Q000648:ultrastructure
Beitrag zur Aktivitätsbeurteilung und zum elektronenoptischen Bild der Pagetschen Krankheit.