Naloxone antagonism of stress-induced augmentation of frontal cortex dopamine metabolism.
Foot shock stress selectively elevates dopamine metabolism in the medial frontal cortex but not nucleus accumbens or caudate nucleus. Pretreatment with a low dose of naloxone, an opiate antagonist, reversed the elevation in medial frontal cortex dopamine metabolism observed after foot shock. These data support the hypothesis that the stress-induced release of endogenous opioids cause an excitation of mesocortical dopamine neurons.
D000818:Animals; D003864:Depression, Chemical; D004298:Dopamine / Q000378:metabolism*; D004597:Electroshock; D005625:Frontal Lobe / Q000378:metabolism*; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological / Q000378:metabolism*
D009270:Naloxone; D004298:Dopamine