title: Pregnancy after heart valve replacement.
abstract: Thirty-two women, aged 21 to 44 years, who had undergone single (25) or multiple (7) heart valve replacement conceived 46 times and gave rise to 33 live-born infants. There were 12 abortions and one stillborn; a premature baby died 24 hr post-partum. Twenty-eight patients had mechanical prostheses and 4 had porcine xenografts, 29 patients being anticoagulated with acenocoumarol during the pregnancy. Cardiac status remained clinically satisfactory under medical treatment in all but one patient who developed heart failure. Fetal complications included cerebral hemorrhage in 1 premature infant, low birth weight in 3 newborns and 1 case of nasal hypoplasia. The incidence of abortion has decreased significantly during the latter part of our experience. It was significantly greater in patients with mitral prostheses. This review suggests that inadequate cardiac function, excessive anticoagulation and a history of primary infertility may increase the risk of abortion. Better control of anticoagulant therapy (accepting an elevation of the therapeutic limit) and improved prevention of pregnancy in high-risk patients are considered responsible for the improved results seen in recent years.
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology; D000328:Adult; D000925:Anticoagulants / Q000009:adverse effects; D002543:Cerebral Hemorrhage / Q000139:chemically induced; D005260:Female; D005313:Fetal Death; D006350:Heart Valve Prosthesis; D006801:Humans; D007231:Infant, Newborn; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular; D011250:Pregnancy Complications, Hematologic / Q000139:chemically induced
chemical_list: D000925:Anticoagulants