title: Regional hyperthermia in the treatment of clinically advanced, deep seated malignancy: results of a pilot study employing an annular array applicator.
abstract: From October 1980 through December 1982, 46 patients were entered into a pilot study at the University of Utah Medical Center to assess the feasibility and safety of heating deep-seated, advanced, pelvic and abdominal malignancies with an annular array of electromagnetic wave (EMW) applicators. The patients, most of whom were heavily pretreated, were treated on a protocol in which most of the patients received combined hyperthermia and low dose X ray therapy. Discomforting local symptoms were the predominant treatment related acute side effects in 28 patients with pelvic disease, while systemic hyperthermia and associated symptoms were the predominant side effects in 18 patients with abdominal disease. Minor subacute toxicity was minimal and no serious treatment related, chronic toxicity was observed. The treatments of 22 patients with sufficiently detailed thermometry were analyzed at arbitrary index temperatures of 41 degrees C and 43 degrees C. Objective response rates in 22 evaluable patients were 67% and 9% for pelvic and abdominal sites respectively.
mesh_terms: D000008:Abdominal Neoplasms / Q000532:radiotherapy / Q000628:therapy*; D000368:Aged; D001831:Body Temperature; D002056:Burns / Q000209:etiology; D003131:Combined Modality Therapy; D005260:Female; D005334:Fever / Q000209:etiology; D006801:Humans; D006979:Hyperthermia, Induced / Q000009:adverse effects / Q000295:instrumentation*; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D010386:Pelvic Neoplasms / Q000532:radiotherapy / Q000628:therapy*; D010865:Pilot Projects; D011879:Radiotherapy Dosage; D013610:Tachycardia / Q000209:etiology