Effect of essential fatty acid deficiency on myelin proteins.
The effect of essential fatty acid (EFA) deficiency on rat-brain myelin proteins was studied. Rats were maintained on a lipid-free diet and compared with control rats fed the same diet supplemented with 3% corn oil. At 17 days of age, each pup was injected with [3H]leucine and rats from each group were killed over a period of 163 days. Although a large decrease occurred in the total amount of myelin protein per brain, the proportions of constituent myelin proteins remained relatively unchanged. Metabolic studies showed a decrease in the net turnover of myelin proteins analogous to that previously demonstrated for myelin phospholipid (PL).
D000818:Animals; D001835:Body Weight; D001921:Brain / Q000378:metabolism; D005228:Fatty Acids, Essential / Q000172:deficiency*; D009185:Myelin Proteins / Q000378:metabolism*; D009929:Organ Size; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D005228:Fatty Acids, Essential; D009185:Myelin Proteins