title: Use of light for footprinting DNA in vivo.
abstract: A new ' photofootprinting ' technique, which uses light to detect protein-DNA contacts as well as changes in the structure of DNA at the base pair level, has been developed and used to detect contacts between lac repressor and the lac operator in Escherichia coli cells.
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000378:metabolism*; D011564:Furocoumarins / Q000494:pharmacology; D007763:Lac Operon; D008027:Light; D009698:Nucleoproteins / Q000378:metabolism*; D010777:Photochemistry; D012097:Repressor Proteins / Q000378:metabolism*; D014157:Transcription Factors / Q000378:metabolism*
chemical_list: D011564:Furocoumarins; D009698:Nucleoproteins; D012097:Repressor Proteins; D014157:Transcription Factors; D004247:DNA