Growth of the fetal lung.
Pulmonary hypoplasia occurs consistently when thoracic volume is reduced by any of a variety of congenital and acquired disorders and supports the hypothesis that distension of the fetal lung is necessary for normal growth. Many of these disorders also impair fetal breathing movements suggesting that growth is dependent on phasic as well as tonic forces. Results of animal experiments to test the hypothesis by obstructing or facilitating outflow of lung fluid are inconclusive but interrupting breathing movements by upper motor neurone lesions that preserve diaphragmatic tone causes hypoplasia. Episodes of breathing may distend the lungs by retaining secreted lung fluid while single breaths may redistribute fluid within the lungs.
D000818:Animals; D001826:Body Fluids / Q000502:physiology; D005333:Fetus / Q000502:physiology; D006128:Growth; D006801:Humans; D008168:Lung / Q000002:abnormalities / Q000196:embryology*; D011312:Pressure; D012137:Respiratory System / Q000196:embryology; D013909:Thorax / Q000196:embryology