[Sclerosing of the parotid gland using a protein solution for instillation in the excretory ducts. Long-term results of animal experiments].
The histological changes of the parotid gland after instillation of a resorbable protein solution into the excretory ducts were investigated by animal experiments. The glands of eleven rabbits were examined twelve months or more after occlusion of the duct system. Atrophy of parenchyma, fibrosis of interstitial tissue and recanalisation of the ducts was found. The epithelial lining of the excretory ducts showed metaplasia, and sometimes even dysplasia. This histological feature is also seen in "necrotizing sialometaplasia" but has no tendency to undergo malignant transformation. The aim of the method described is elimination of secretory parenchyma. It depends on three mechanisms: suppression of secretion, chemical influence of the solution on tissue, and diminution of acinar blood supply. Complications such as abscesses or fistula occurred after paraductal instillation of the solution, or when the recanalization of the ducts was disturbed. Compared to ligation of Stensen's duct this method has some advantages in the treatment of chronic recurrent parotitis, sialadenosis, salivary fistulae or sialorrhea.
D000818:Animals; D005500:Follow-Up Studies; D010305:Parotid Diseases / Q000628:therapy; D010306:Parotid Gland / Q000187:drug effects* / Q000473:pathology; D011506:Proteins / Q000008:administration & dosage; D011817:Rabbits; D012597:Sclerosing Solutions / Q000009:adverse effects*; D013997:Time Factors
D011506:Proteins; D012597:Sclerosing Solutions
Verödung der Glandula parotis durch Ausguss ihres Gangsystems mit einer Eiweisslösung. Langzeitergebnisse im Tierexperiment.