In vivo cytogenetic effects of the cooked-food-related mutagens Trp-P-2 and IQ in mouse bone marrow.
Sister-chromatid exchange and chromosomal aberrations were measured in vivo in mouse bone marrow following intraperitoneal injection of the cooked food mutagens, Trp-P-2 and IQ. Trp-P-2 produced a significant positive dose response for both endpoints while IQ produced only a weak but significant sister-chromatid exchange response. The relative potency of these two chemicals is similar to that seen in mammalian cells in vitro but opposite to their potency in Salmonella.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects*; D002243:Carbolines / Q000633:toxicity*; D002869:Chromosome Aberrations; D003434:Crossing Over, Genetic / Q000187:drug effects*; D003520:Cyclophosphamide / Q000633:toxicity; D005502:Food; D006358:Hot Temperature; D007211:Indoles / Q000633:toxicity*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D011804:Quinolines / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D002243:Carbolines; D007211:Indoles; D009153:Mutagens; D011804:Quinolines; C029216:2-amino-3-methylimidazo(4,5-f)quinoline; C019133:3-amino-1-methyl-5H-pyrido(4,3-b)indole; D003520:Cyclophosphamide