Human chorionic gonadotropin-secreting pure dysgerminoma.
A young woman with a preoperative diagnosis of molar pregnancy was found to have a pure dysgerminoma in the right ovary. Immunohistochemical study of formalin-fixed tissue revealed human chorionic gonadotropin-secreting small stromal cells. This is in contradistinction to previous reports of functioning dysgerminomas, in which the secretory activity was associated with the presence of syncytiotrophoblasts and chorionic tissue. Reports of ultrastructural and biochemical analyses of pure dysgerminomas confirming this observation are discussed.
D000328:Adult; D006063:Chorionic Gonadotropin / Q000378:metabolism*; D004407:Dysgerminoma / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology
D006063:Chorionic Gonadotropin