[Age-related characteristics of the effect of adrenomimetics on the noradrenaline and adrenaline content in the myocardium of the rat].
White random-bred rats aged 7-30 days and 3-5 months were given a single intraperitoneal injection of the adrenomimetics, noradrenaline (0.025 mg/kg), isadrin (0.1 mg/kg) and ephedrine (5 mg/kg). In the myocardium, the content of noradrenaline and adrenaline was measured by fluorometry. The sensitivity of catecholamines of the heart muscle to exogenous sympathomimetics was discovered to change depending on the degree of maturity of the mechanisms of sympathetic regulation and features of metabolism in an individual age period. Possible mechanisms of the action of adrenomimetics on the myocardium in early ontogenesis are discussed.
D000375:Aging / Q000187:drug effects*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000378:metabolism*; D005260:Female; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D013566:Sympathomimetics / Q000494:pharmacology*; D013997:Time Factors
D013566:Sympathomimetics; D009638:Norepinephrine; D004837:Epinephrine
Vozrastnye osobennosti vliianiia adrenomimetikov na soderzhanie noradrenalina i adrenalina v miokarde krys.