Flare-up reactions and desensitization from oral dosing in chromate-sensitive guinea pigs.
Flare-up reactions were induced in potassium dichromate hypersensitive guinea pigs by a single oral dose of 55 mg/kg. This dose is systemically toxic and higher than the dose required to induce the same reactions in humans. A total oral dose of potassium dichromate of 90-115 mg/kg induced immunological unresponsiveness for at least 6 weeks. With limitations, the guinea pig model may be helpful in screening the hyposensitization capacity of different haptens dosed orally.
D000284:Administration, Oral; D000818:Animals; D002840:Chromates / Q000008:administration & dosage; D003888:Desensitization, Immunologic; D004195:Disease Models, Animal; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000276:immunology; D006168:Guinea Pigs; D010328:Patch Tests; D011192:Potassium Dichromate / Q000008:administration & dosage; D013997:Time Factors
D002840:Chromates; D011192:Potassium Dichromate