Nasal polyposis in a chimpanzee.
A 15-year-old female chimpanzee with nasal polyposis sustained respiratory compromise when she was sedated and expired despite resuscitative efforts. Postmortem examination revealed very large fibromyxomatous nasal polyps completely obstructing the upper airway. Gross examination and histopathologic findings were indistinguishable from those of human polyps. The chimpanzee is a potential animal model for nasal polyposis that could provide basic information concerning the relationship of polyps to type I hypersensitivity and to three severe respiratory tract disorders in humans: cystic fibrosis, bronchial asthma, and the immotile cilia syndrome.
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D009058:Mouth Breathing; D009298:Nasal Polyps / Q000473:pathology / Q000662:veterinary*; D002679:Pan troglodytes; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000401:mortality