Age pigments: role of iron and copper salts in the formation of fluorescent lipid complexes.
Free radicals which abstract hydrogen atoms from unsaturated fatty acids initiate lipid autoxidation. Transition metal ions, however, usually stimulate lipid autoxidation by decomposing peroxides to release active radicals which can then initiate further autoxidation. Lipid peroxides produced in vivo, both enzymically and non-enzymically, are probably decomposed in this way resulting in the formation of fluorescent lipid complexes. The role of iron and copper salts in their formation has been studied using sequential techniques on fatty acid and phospholipid preparations.
D000818:Animals; D001921:Brain / Q000378:metabolism; D002417:Cattle; D003300:Copper / Q000378:metabolism*; D005227:Fatty Acids / Q000378:metabolism; D007501:Iron / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D010860:Pigments, Biological / Q000378:metabolism*
D005227:Fatty Acids; D008054:Lipid Peroxides; D008081:Liposomes; D010743:Phospholipids; D010860:Pigments, Biological; D003300:Copper; D007501:Iron