Interaction of Solanum tuberosum agglutinin with human platelets.
Solanum tuberosum agglutinin (STA) binds to the surface of human platelets and leads to their agglutination. Lectin staining shows that 125I-STA most intensely labels a major platelet membrane glycoprotein identified as GPIIIa followed by GPIV . STA does not induce release reaction, TXB2 formation or platelet protein phosphorylation. Since STA-induced agglutination is independent of intracellular metabolism of platelets, STA may prove to be a useful tool to explore the clinical condition in which the composition of platelet membrane protein is altered.
D001792:Blood Platelets / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D003594:Cytoplasmic Granules / Q000187:drug effects; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D037102:Lectins / Q000494:pharmacology*; D008565:Membrane Proteins / Q000097:blood; D010750:Phosphoproteins / Q000097:blood; D037121:Plant Lectins; D010974:Platelet Aggregation / Q000187:drug effects*; D010976:Platelet Count; D013929:Thromboxane B2 / Q000096:biosynthesis
D001798:Blood Proteins; D006023:Glycoproteins; D037102:Lectins; D008565:Membrane Proteins; D010750:Phosphoproteins; D037121:Plant Lectins; C041202:potato lectin; D013929:Thromboxane B2