Extracellular ascorbic acid increases in striatum following systemic amphetamine.
Push-pull perfusion of the anterior striatum was performed in freely moving rats which were administered 4 mg/kg d-amphetamine sulfate. Ascorbic acid was measured in the perfusate using high performance liquid chromatography with electrochemical detection. Increased extracellular ascorbic acid resulted from the amphetamine, lasting over a period of two hours. The time course of the increase corresponded to the increased oxidation current measured by intrastriatal chonoamperometry under equivalent conditions.
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003342:Corpus Striatum / Q000378:metabolism*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004563:Electrochemistry; D005110:Extracellular Space / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D051381:Rats
D001205:Ascorbic Acid; D003913:Dextroamphetamine