Increased myofibrillar protein catabolism in duchenne muscular dystrophy measured by 3-methylhistidine excretion in the urine.
Myofibrillar protein catabolic rate was calculated in 50 young patients with Duchenne muscular dystrophy from the amount of 3-methylhistidine excreted in the urine, and was found to be about seven times that of a control series, expressed as the percentage of myofibrillar protein catabolized per day. This wastage of myofibrillar protein is a consequence of Duchenne muscular dystrophy and inhibition of protein degradation appears to be one possible approach in the treatment of this disease.
D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine; D006639:Histidine / Q000031:analogs & derivatives*; D006801:Humans; D008762:Methylhistidines / Q000652:urine*; D009124:Muscle Proteins / Q000378:metabolism*; D009136:Muscular Dystrophies / Q000652:urine*; D009210:Myofibrils / Q000378:metabolism*
D008762:Methylhistidines; D009124:Muscle Proteins; D006639:Histidine; D003404:Creatinine; C028118:3-methylhistidine