Quantitative analysis of trimethobenzamide hydrochloride by ion-pair column chromatography and semiquantitative analysis of 3,4,5-trimethoxybenzoic acid by thin-layer chromatography.
An ion-pair column chromatographic/UV spectrophotometric method for assaying trimethobenzamide hydrochloride in capsules and injections is presented, as well as a method for the detection of 3,4,5- trimethoxybenzoic acid in trimethobenzamide hydrochloride bulk drug and dosage forms. Results obtained by the USP XX, Pharmacopeial Forum, and ion-pair column assay procedures are compared, and results of a collaborative study of the proposed assay and impurity detection methods are presented.
D001549:Benzamides / Q000032:analysis*; D002214:Capsules / Q000032:analysis; D002852:Chromatography, Ion Exchange / Q000379:methods; D002855:Chromatography, Thin Layer / Q000379:methods; D005707:Gallic Acid / Q000031:analogs & derivatives* / Q000032:analysis; D012996:Solutions / Q000032:analysis
D001549:Benzamides; D002214:Capsules; D012996:Solutions; D005707:Gallic Acid; C005854:3,4,5-trimethoxybenzoic acid; C100146:trimethobenzamide