Preparation of 11 alpha-hemisuccinyl-progesterone for immunological purposes and structural determination of the hapten.
Progress in reproductive endocrinology to some extent is due to the application of immunogens produced from synthetic haptens. In this preliminary study the synthesis of the hapten 11 alpha-hemisuccinyl-progesterone (11 alpha-hemisuccinyl-pregn-4-ene-3,20-dione) from 11 alpha-hydroxy-progesterone and its complete structure elucidation by u.v./VIS, i.r., [1H]NMR-spectroscopy and E.I.-mass-spectrometry is described. Estimates of sample purity are given.
D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006241:Haptens; D006908:Hydroxyprogesterones / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013053:Spectrophotometry
D006241:Haptens; D006908:Hydroxyprogesterones; D007202:Indicators and Reagents; C030250:progesterone 11-hemisuccinate