Bioavailability of cyclophosphamide from oral formulations.
Cyclophosphamide (CP) is an alkylating cytostatic compound, which is activated to its cytotoxic form in the liver [1]. Since the therapeutic range of CP in the treatment of human tumours, is small like other cytostatics, a constant high bioavailability is essential for its oral administration. Although CP has become one of the most widely used cytostatics [2], there do not appear to have been any bioavailability investigations providing the necessary information. The development of a very sensitive gas chromatographic analytical method has now permitted investigation of the pharmacokinetics of oral CP in conventional clinical doses [3, 4, 5, 6].
D001682:Biological Availability; D003520:Cyclophosphamide / Q000008:administration & dosage* / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D013607:Tablets
D013607:Tablets; D003520:Cyclophosphamide