Effects of bromocriptine on pancreatic secretion in the isolated, blood-perfused pancreas of the dog.
Effects of bromocriptine on the secretion of pancreatic juice were investigated with dog isolated, blood-perfused pancreas. Bromocriptine (1-10 mg) caused dose-dependent increases in the secretion of pancreatic juice. However, bromocriptine did not affect the perfusion blood flow rate. The secretory response to bromocriptine was inhibited by pretreatment with a dopamine antagonist, sulpiride, but not by phentolamine, propranolol, atropine, metiamide, indomethacin or tetrodotoxin. Bromocriptine caused a dopamine-like secretion of the pancreatic juice containing a high concentration of bicarbonate but had little effect on protein output. These results suggest that bromocriptine increases pancreatic secretion stimulating directly on pancreatic dopamine receptors.
D000818:Animals; D001769:Blood; D001971:Bromocriptine / Q000494:pharmacology*; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010189:Pancreatic Juice / Q000378:metabolism; D010477:Perfusion; D011954:Receptors, Dopamine / Q000187:drug effects
D011954:Receptors, Dopamine; D001971:Bromocriptine; D004298:Dopamine