Spontaneous lesions of the mouse biliary tract.
During the routine histological examination of 2400 aged mice from lifespan carcinogenicity studies a low prevalence of glandular metaplasia of the gall bladder and of the intra-hepatic bile ducts (all associated with cholelithiasis), cholecystitis, cholangitis, papillomatous hyperplasia, papilloma, intra-mural cysts, and focal epithelial ulceration was found. The lesions were found predominantly in female mice and were not treatment related.
D000818:Animals; D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D001660:Biliary Tract Diseases / Q000662:veterinary*; D002761:Cholangitis / Q000473:pathology; D002764:Cholecystitis / Q000473:pathology; D003560:Cysts / Q000473:pathology; D005260:Female; D005704:Gallbladder / Q000473:pathology; D005705:Gallbladder Diseases / Q000473:pathology; D005706:Gallbladder Neoplasms / Q000473:pathology; D006965:Hyperplasia; D008297:Male; D008679:Metaplasia; D051379:Mice; D008815:Mice, Inbred Strains; D010212:Papilloma / Q000473:pathology; D012376:Rodent Diseases / Q000473:pathology*; D014456:Ulcer / Q000473:pathology