The ocular hypotensive action of SK&F 86466 in the conscious rabbit.
SK&F 86466, 6-chloro-3-methyl-2, 3, 4, 5-tetrahydro-1H-3-benzazepine, a potent and selective competitive antagonist of the alpha 2-adrenoceptor is of interest as a potential antiglaucoma agent. Following instillation into the rabbit eye, SK&F 86466 produced concentration (0.25 to 10%) dependent reductions in intraocular pressure (IOP). The ocular hypotensive effect of SK&F 86466 was maximal 30-60 minutes post treatment and persisted for at least 90 minutes. The IOP of the contralateral (untreated) eye was significantly decreased only at the 10% concentration. A 10% solution of SK&F 86466 had no significant effect on mean arterial blood pressure (MAP) of rabbits during the time of maximal bilateral ocular hypotensive activity. These results suggest: (1) a selective alpha 2-adrenoceptor antagonist can reduce IOP when applied topically to rabbit eyes and (2) the ocular hypotensive effect of SK&F 86466 is not secondary to a reduction in systemic blood pressure.
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001552:Benzazepines / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D005902:Glaucoma, Open-Angle / Q000188:drug therapy; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D011817:Rabbits
D000959:Antihypertensive Agents; D001552:Benzazepines; C039139:benalfocin