title: Activated alpha-alkyl-alpha-arylacetic acid enantiomers for stereoselective thin-layer chromatographic and high-performance liquid chromatographic determination of chiral amines.
abstract: The separation of racemic benoxaprofen into the two benoxaprofen enantiomers by preparative high-performance liquid chromatography and the application of the activated enantiomers as derivatization reagents for the simultaneous stereoselective determination of chiral amines in biological material is described. Activated (+)- and (-)-benoxaprofen are both shown to be very sensitive and stable chiral fluorescence markers, applicable to thin-layer chromatography as well as to high-performance liquid chromatography.
mesh_terms: D000588:Amines / Q000097:blood*; D000661:Amphetamine / Q000097:blood; D001596:Benzylamines / Q000097:blood; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006868:Hydrolysis; D008694:Methamphetamine / Q000032:analysis; D011422:Propionates / Q000032:analysis; D013237:Stereoisomerism; D014191:Tranylcypromine / Q000097:blood
chemical_list: D000588:Amines; D001596:Benzylamines; D011422:Propionates; C029991:N-methylbenzylamine; C011677:benoxaprofen; D014191:Tranylcypromine; D008694:Methamphetamine; D000661:Amphetamine