title: Fatal hemorrhage from minor trauma following massive salicylate ingestion.
abstract: The anticoagulant property of aspirin has long been appreciated. Recently, the physiologic mechanism has been identified and documented extensively. Despite the long-lasting inhibition of platelet function and clinically significant postoperative hemorrhage following aspirin use, few serious complications or fatalities are reported in the current literature. We report a case in which fatal hemorrhage resulted from minor trauma following massive salicylate ingestion. A review of the cyclo-oxygenase mechanism is presented.
mesh_terms: D000437:Alcoholism / Q000150:complications; D001241:Aspirin / Q000009:adverse effects*; D003645:Death, Sudden / Q000209:etiology*; D006470:Hemorrhage / Q000139:chemically induced / Q000209:etiology*; D006801:Humans; D008171:Lung Diseases / Q000139:chemically induced; D008297:Male; D008477:Mediastinal Diseases / Q000139:chemically induced; D008875:Middle Aged; D011693:Purpura / Q000139:chemically induced; D012459:Salicylates / Q000009:adverse effects; D013921:Thrombocytopenia / Q000139:chemically induced; D014949:Wounds, Nonpenetrating / Q000150:complications
chemical_list: D012459:Salicylates; D001241:Aspirin