[Peripheral circulatory effects of sodium nitroprussate. Evaluation by plethysmography and capillaroscopy].
Circulatory effects of intravenous injection of sodium nitroprusside are appreciated in 6 patients by monitoring systemic pressure, heart rate, digital systolic pressure, pulse plethysmography and nail-fold capillaroscopy. Low doses of nitroprusside (1.5 microg./kg/mn) enhance digital blood flow (+ 78.9%) and maximum height of the plethysmographic curve (+ 71.6%), without any significant modification of the systemic blood pressure (- 0.6%), heart rate (+ 6.3%) and digital pressure (- 1.15%). The peripheral resistances are strongly reduced. Nail fold capillaroscopy is unchanged. Higher doses, even with an adequate vascular filling, are potentially harmful for microcirculation.
D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002196:Capillaries / Q000187:drug effects; D005292:Ferricyanides / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D009599:Nitroprusside / Q000494:pharmacology*; D010991:Plethysmography; D011674:Pulse / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects*; D013524:Surgical Flaps
D005292:Ferricyanides; D009599:Nitroprusside
Effets circulatoires périphériques du nitroprussiate de sodium. Appréciation par pléthysmographie et capillaroscopie.