Amoxapine and amitriptyline: serum levels and clinical response in patients with primary unipolar depression.
Amoxapine, a new antidepressant of the dibenzoxazepine class, was compared with amitriptyline in 80 patients with primary unipolar depressive disorders. In a four-week double-blind trial, the two medications were equally effective and had similar onsets of therapeutic action. The range of side effects was similar, although there was a trend for fewer side effects in the amoxapine group. Serum levels were not related to therapeutic response for either medication.
D000293:Adolescent; D000328:Adult; D000553:Ambulatory Care; D000639:Amitriptyline / Q000097:blood* / Q000627:therapeutic use; D000657:Amoxapine / Q000097:blood* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003866:Depressive Disorder / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D003989:Dibenzoxazepines / Q000097:blood*; D004311:Double-Blind Method; D006801:Humans; D008875:Middle Aged; D009661:Nortriptyline / Q000097:blood; D011569:Psychiatric Status Rating Scales
D003989:Dibenzoxazepines; D000639:Amitriptyline; D009661:Nortriptyline; D000657:Amoxapine