On suppression of ejaculation by Alpha-methyldopa.
Alpha-methyldopa caused inhibition of ejaculation. The cerebral mechanism which induced the inhibition was pursued by determining changes of brain monoamines in dogs. As a result, suppression of the dopaminergic system in the brain by alpha-methyldopa is found to be the origin of the inhibition of ejaculation. This inhibition was recovered by L-dopa with pretreatment with a peripheral decarboxylase inhibitor.
D000818:Animals; D001679:Biogenic Amines / Q000032:analysis*; D001923:Brain Chemistry / Q000187:drug effects*; D003864:Depression, Chemical; D004285:Dogs; D004298:Dopamine / Q000032:analysis; D004542:Ejaculation / Q000187:drug effects*; D006624:Hippocampus / Q000032:analysis; D007032:Hypothalamus, Anterior / Q000032:analysis; D008297:Male; D008750:Methyldopa / Q000494:pharmacology*; D009638:Norepinephrine / Q000032:analysis; D012701:Serotonin / Q000032:analysis
D001679:Biogenic Amines; D012701:Serotonin; D008750:Methyldopa; D004298:Dopamine; D009638:Norepinephrine