[Substances with central nervous system activity. Derivatives of 2,3,5,9b-tetrahydro-1,3-dioxo-1H-imidazo[5,1-a]isoindole-5 -carboxylic acid].
The AA. describe the synthesis of some methyl esters of 2-alkyl or 2-aryl-2,3,5, 9b -tetrahydro-1,3-dioxo-1H-imidazo[5,1-a] isoindol -5-carboxylic acids and of the corresponding acids. From these acids some aliphatic and heterocyclic amides were synthesized. The pharmacological data of these compounds are also reported.
D000818:Animals; D002415:Cats; D002492:Central Nervous System Depressants / Q000138:chemical synthesis* / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D003216:Conditioning, Operant / Q000187:drug effects; D004285:Dogs; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007928:Lethal Dose 50; D051379:Mice; D051381:Rats; D013045:Species Specificity
D002492:Central Nervous System Depressants; D006993:Hypnotics and Sedatives; D007093:Imidazoles
Sostanze attive sul sistema nervoso centrale. Derivati degli acidi 2,3,5,9b-tetraidro-1,3-diosso-1H-imidazo [5,1-a]isoindol-5-carbossilici.