title: Influence of ingested lead on the distribution of lead, iron, zinc, copper and manganese in bovine tissues.
abstract: Five groups of cattle were dosed daily with either 0, 6.3, 7.8, 9.8 and 12.2 mg of lead/kg of body weight for 118 days or for as long as they lived, and tissue concentrations of lead, iron, zinc, copper and manganese were determined post-mortem. Mean intakes of lead for the five groups were 0, 34, 165, 55 and 57 g respectively. Lead accumulated in all tissues of treated animals and was greatest in kidneys and liver. The accumulation of lead and iron in livers of the treated animals appeared to be related to lead intake. The zinc and iron concentrations in liver were significantly increased by the ingestion of lead whereas the copper concentrations in liver and heart and the manganese concentration in kidney were significantly decreased by the ingestion of the lead.
mesh_terms: D000818:Animals; D002417:Cattle / Q000378:metabolism*; D003300:Copper / Q000378:metabolism; D004032:Diet; D005260:Female; D007501:Iron / Q000378:metabolism; D007854:Lead / Q000378:metabolism / Q000494:pharmacology*; D008297:Male; D008345:Manganese / Q000378:metabolism; D008670:Metals / Q000378:metabolism*; D014018:Tissue Distribution; D014131:Trace Elements / Q000032:analysis; D014881:Water Supply / Q000032:analysis; D015032:Zinc / Q000378:metabolism
chemical_list: D008670:Metals; D014131:Trace Elements; D007854:Lead; D008345:Manganese; D003300:Copper; D007501:Iron; D015032:Zinc