Hodgkin's disease and subacute cerebellar degeneration. A case report and review of the literature.
Case history of a 20-year old man with Hodgkin's disease, clinical stage I, lymphocytic predominance, complicated by a subacute cerebellar degeneration, which was diagnosed by computed tomography scan. Following local radiotherapy, cerebellar and brain stem symptoms and signs had a complete regression. Two months later, a recurrence of the neurological picture was recorded: polychemotherapy (MOPP) was then administered and after 5 courses the symptoms improved considerably. The association of subacute cerebellar degeneration with Hodgkin's disease is rare: only 10 cases have previously been described. Pathogenesis of cerebellar atrophy complicating tumors is undetermined.
D000328:Adult; D002526:Cerebellar Diseases / Q000150:complications* / Q000000981:diagnostic imaging; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D008297:Male; D014057:Tomography, X-Ray Computed