title: Plasma bupivacaine concentrations during combined regional and general anaesthesia for resection and reconstruction of head and neck carcinomata.
abstract: Venous plasma bupivacaine concentrations were measured in patients undergoing resection and reconstruction surgery for intra-oral malignancy. Vth cranial nerve and cervical plexus blocks were performed using 0.5% bupivacaine. Total dosage was higher than recommended by U.K. manufacturers. Mean peak venous plasma concentrations were higher than previously recorded. A significant different was found in the peak concentrations when adrenaline was included. The significance of these results in relation to systemic toxicity and recommended dosage is discussed.
mesh_terms: D000368:Aged; D000765:Anesthesia, Conduction; D000768:Anesthesia, General; D002045:Bupivacaine / Q000097:blood*; D002572:Cervical Plexus; D004837:Epinephrine; D005260:Female; D006258:Head and Neck Neoplasms / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009407:Nerve Block; D013518:Surgery, Plastic; D013997:Time Factors
chemical_list: D002045:Bupivacaine; D004837:Epinephrine