Interaction between reserpine and non-steroidal anti-inflammatory agents in producing gastric ulcers in rats.
The interaction between reserpine and nonsteroidal anti-inflammatory agents ( NSAIA ) in producing experimental gastric ulcers was studied in rats. The ulcerating effects of reserpine, indomethacin, ketoprofen and phenylbutazone were found to be dose-dependent. The area of gastric mucosal lesions was highly significantly increased if NSAIA were injected intraperitoneally 3 min after reserpine. Reserpine and NSAIA in doses which by themselves did not produce gastric mucosal damage, induced gastric ulcers in all experimental animals when injected simultaneously.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D007213:Indomethacin / Q000633:toxicity; D007660:Ketoprofen / Q000633:toxicity; D010653:Phenylbutazone / Q000633:toxicity; D051381:Rats; D012110:Reserpine / Q000633:toxicity*; D013276:Stomach Ulcer / Q000139:chemically induced*
D000893:Anti-Inflammatory Agents; D012110:Reserpine; D007660:Ketoprofen; D010653:Phenylbutazone; D007213:Indomethacin