Theory of ligand-receptor interactions--evidence for more than one site.
Receptor binding studies usually show heterogenic characteristics of the binding isotherm. Scatchard transformation for graphical linearization of the data presentation affects the data inhomogeneously with respect to the experimental error. Thus a non-linear fitting procedure should be preferred for data analysis. Furthermore this approach allows for reliable weighting of the measurements according to the experimental error.
D000818:Animals; D001665:Binding Sites; D002462:Cell Membrane / Q000378:metabolism; D007700:Kinetics; D008024:Ligands / Q000378:metabolism*; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism; D019832:N-Methylscopolamine; D010042:Ouabain / Q000378:metabolism*; D010306:Parotid Gland / Q000378:metabolism; D051381:Rats; D011955:Receptors, Drug / Q000378:metabolism*; D012602:Scopolamine Derivatives / Q000378:metabolism; D000254:Sodium-Potassium-Exchanging ATPase
D008024:Ligands; D011955:Receptors, Drug; D012602:Scopolamine Derivatives; C028996:cardiac glycoside receptors; D010042:Ouabain; D000254:Sodium-Potassium-Exchanging ATPase; D019832:N-Methylscopolamine