Identification of a plasma metabolite of 5-(2-bromo-E-ethenyl)-2'-deoxyuridine.
A prominent plasma metabolite was detected in animals and man after oral administration of 5-(2-bromo-E- ethenyl )-2'-deoxyuridine. The metabolite was isolated by solvent extraction and high-performance liquid chromatography and was identified by mass spectrometry as 5-(2-bromo-E- ethenyl )uracil.
D000284:Administration, Oral; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage*; D003857:Deoxyuridine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D004285:Dogs; D006564:Herpesviridae / Q000187:drug effects; D006801:Humans; D008253:Macaca mulatta; D013058:Mass Spectrometry; D011817:Rabbits; D051381:Rats
D000998:Antiviral Agents; C032447:5-bromoethynyl-2'-deoxyuridine; D003857:Deoxyuridine