title: Mastication and acid secretion.
abstract: The gastric acid response and the buffer capacity of the stomach were measured in 30 control subjects and 22 duodenal ulcer patients in response to a masticatory (solid) and a non-masticatory (homogenized) meal having the same chemical composition. The peak acid output values were equal after a masticatory and after a non-masticatory diet in control subjects (masticatory 18.1 +/- 1.2, non-masticatory 15.7 +/- 1.3 mmol/hr) as well as in duodenal ulcer patients (masticatory 35.7 +/- 1.5, non-masticatory 33.7 +/- 1.1 mmol/hr). The buffer capacity of the stomach contents 1 hr after the meal was significantly greater after a masticatory diet than a non-masticatory diet in both controls (14.6 +/- 1.4 and 9.0 +/- 1.9 mmol) and in duodenal ulcer patients (9.5 +/- 1.5 and 7.5 +/- 1.2 mmol). Duodenal ulcer patients had a significantly lower buffer capacity compared with controls. Masticatory diets may play a part in protecting individuals from developing duodenal ulcer.
mesh_terms: D000328:Adult; D002021:Buffers; D004032:Diet; D004381:Duodenal Ulcer / Q000503:physiopathology*; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000503:physiopathology; D006632:Histamine; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008409:Mastication; D012463:Saliva / Q000502:physiology
chemical_list: D002021:Buffers; D006632:Histamine