[Sugar transport regulation in vitro by new calcium ionophores].
The influence of calcium ionophores--tenoyltrifluoroacetate (TTFA) and divaleryldibenzo-18-crown-6(divaleryl) on the glucose consumption, D-xylose transport and glycogen content in rat diaphragm was studied. TTFA caused a clear dose-dependent inhibition of carbohydrate transport and glycogenolysis stimulation. Divaleryl, on the other hand, raised glucose consumption, D-xylose transport without influencing glycogen content. Exclusion of Ca++ from incubation medium increased the TTFA inhibiting effect on glucose consumption, decreased its glycogenolytic effect and removed divaleryl induced stimulation of glucose transport. Mechanisms of calcium ionophore action and a possible role of intracellular Ca2+ in carbohydrate transport are discussed.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002118:Calcium / Q000378:metabolism*; D050260:Carbohydrate Metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D043844:Crown Ethers; D003964:Diaphragm / Q000187:drug effects / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism; D004988:Ethers, Cyclic / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007476:Ionophores / Q000494:pharmacology*; D008297:Male; D051381:Rats; D013804:Thenoyltrifluoroacetone / Q000494:pharmacology*; D013876:Thiophenes / Q000494:pharmacology*; D014994:Xylose / Q000378:metabolism
D043844:Crown Ethers; D004988:Ethers, Cyclic; D007476:Ionophores; D013876:Thiophenes; D013804:Thenoyltrifluoroacetone; C041761:2,13-divaleryldibenzo-18-crown-6; D014994:Xylose; D005947:Glucose; D002118:Calcium
Reguliatsiia transporta sakharov in vitro novymi kal'tsievymi ionoforami.