Beta-tricalcium phosphate delivery system for bone morphogenetic protein.
An aggregate of biodegradable beta-tricalcium phosphate and bone morphogenetic protein (BMP/TCP) induces the differentiation of cartilage within eight days, cartilage and woven bone within 12 days, and lamellar bone, including bone marrow, within 21 days. The yield of new bone from a 1-mg dose was more than 12 times greater from the TCP/BMP than from the BMP alone. Whether TCP acts as a slow-release delivery system, potentiates the activity of BMP, or serves to distribute BMP in a favorable three-dimensional pattern requires further investigation.
D000818:Animals; D001672:Biocompatible Materials / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects; D019485:Bone Morphogenetic Proteins; D002130:Calcium Phosphates / Q000494:pharmacology*; D002356:Cartilage / Q000187:drug effects; D002417:Cattle; D002454:Cell Differentiation / Q000187:drug effects; D004338:Drug Combinations; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D051379:Mice; D008815:Mice, Inbred Strains; D010012:Osteogenesis / Q000187:drug effects; D011506:Proteins / Q000494:pharmacology*; D013997:Time Factors
D001672:Biocompatible Materials; D019485:Bone Morphogenetic Proteins; D002130:Calcium Phosphates; D004338:Drug Combinations; D006133:Growth Substances; D011506:Proteins; C485817:beta-tricalcium phosphate; C018392:tricalcium phosphate