[Effect of dihydroergotamine on blood circulation in man in conditions of orthostasis].
The physiological effects of zero-g were simulated by 6-hour antiorthostatic hypokinesia at -15 degrees, using eight healthy volunteers. They took part in two experimental runs at a 2 week interval. During the first study the test subjects received a placebo and during the second study they got 6 mg dihydroergotamine methane sulfonate per os. Radiometric examinations of the whole body and its compartments (head, chest, abdomen, legs) showed that the drug increased blood pooling in the upper body and decreased it in the lower body at every position of the long axis of the body relative to the gravity vector.
D000328:Adult; D001775:Blood Circulation / Q000187:drug effects*; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume / Q000187:drug effects; D004087:Dihydroergotamine / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D010953:Plasma Volume / Q000187:drug effects; D011187:Posture
D004087:Dihydroergotamine
Vliianie digidroérgotamina na gemotsirkuliatsiiu cheloveka v usloviiakh ortostaza.