An improved cold stress test for aging mice.
Tolerance to cold stress is a simple and reliable test which can be used longitudinally to study age-related differences or changes in thermoregulation of C57BL/6J mice. Neither prior food deprivation nor permanently inserted thermoprobes are necessary conditions for eliciting reliable age differences. However, restraint during the test is important and does elicit reliable age differences.
D000375:Aging; D000818:Animals; D001833:Body Temperature Regulation; D003080:Cold Temperature; D051379:Mice; D008810:Mice, Inbred C57BL; D010827:Physiology / Q000379:methods*; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000503:physiopathology