title: Preparation of 11 alpha-hemisuccinyl-progesterone for immunological purposes and structural determination of the hapten.
abstract: Progress in reproductive endocrinology to some extent is due to the application of immunogens produced from synthetic haptens. In this preliminary study the synthesis of the hapten 11 alpha-hemisuccinyl-progesterone (11 alpha-hemisuccinyl-pregn-4-ene-3,20-dione) from 11 alpha-hydroxy-progesterone and its complete structure elucidation by u.v./VIS, i.r., [1H]NMR-spectroscopy and E.I.-mass-spectrometry is described. Estimates of sample purity are given.
mesh_terms: D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D006241:Haptens; D006908:Hydroxyprogesterones / Q000138:chemical synthesis*; D007202:Indicators and Reagents; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D013053:Spectrophotometry
chemical_list: D006241:Haptens; D006908:Hydroxyprogesterones; D007202:Indicators and Reagents; C030250:progesterone 11-hemisuccinate