title: The level of thyroglobulin mRNA is regulated by TSH both in vitro and in vivo.
abstract: We have studied the effect of thyrotropin on the intracellular concentration of thyroglobulin and of its mRNA both in a differentiated rat thyroid cell line and in the rat thyroid in vivo. Our data demonstrate that the absence of thyrotropin causes a two fold decrease of both thyroglobulin and of its mRNA suggesting that thyroglobulin synthesis in thyroid cells is 50% constitutive.
mesh_terms: D000818:Animals; D004247:DNA; D066298:In Vitro Techniques; D009693:Nucleic Acid Hybridization; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D013954:Thyroglobulin / Q000096:biosynthesis / Q000235:genetics*; D013961:Thyroid Gland / Q000378:metabolism*; D013972:Thyrotropin / Q000502:physiology*
chemical_list: D012333:RNA, Messenger; D013972:Thyrotropin; D004247:DNA; D013954:Thyroglobulin