Regional cerebral blood flow and stroke index after left carotid artery ligation in the conscious gerbil.
We measured the regional cerebral blood flow in both hemispheres of Mongolian gerbils subjected to permanent left carotid artery ligation, using [3H]nicotine as the tracer. At 1, 3 and 6 h post-ligation, neurological signs were recorded and a stroke index score was tallied for each animal. In conscious control gerbils, mean cerebral blood flow on the left side was 1.10 +/- 0.08 (S.E.M.) ml X g-1 X min-1 at the cerebral cortex, 0.58 +/- 0.02 at the hippocampus and 0.69 +/- 0.04 at the diencephalon. Animals with a stroke index score exceeding 10 were considered symptomatic. We noted a close relationship between regional cerebral blood flow and the stroke index score. In symptomatic animals, regional cerebral blood flow in the ischemic hemisphere at 1, 3 and 6 h post-ligation was less than 0.21 ml X g-1 X min-1 at the cortex and diencephalon, and less than 0.09 ml X g-1 X min-1 at the hippocampus. We suggest that unilaterally ligated gerbils manifesting a stroke index score greater than 10 represent a good experimental model for the study of ischemia.
D000818:Animals; D002545:Brain Ischemia; D002339:Carotid Arteries; D002560:Cerebrovascular Circulation; D004195:Disease Models, Animal; D005849:Gerbillinae; D008026:Ligation; D013997:Time Factors