The developing placenta in selecting potential radiopharmaceuticals for tumour-localizing properties: a simple in vivo pre-screening model.
The tissue distribution of various radiopharmaceuticals was investigated in rhabdomyosarcoma-bearing and in pregnant rats during the period of rapid foetal and placental growth (days 17-19 of pregnancy). The preliminary results indicate that with the radiopharmaceuticals tested the uptake in placental tissue followed closely the data obtained with tumour tissue in rhabdomyosarcoma-bearing rats.
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008297:Male; D010920:Placenta / Q000528:radiation effects*; D011247:Pregnancy; D011868:Radioisotopes; D011877:Radionuclide Imaging; D051381:Rats; D012208:Rhabdomyosarcoma / Q000000981:diagnostic imaging* / Q000378:metabolism; D014018:Tissue Distribution
D011868:Radioisotopes