Nasal responsiveness to methacholine stimulation in allergic rhinitis patients.
We examined the nasal responsiveness to topical methacholine application in allergic rhinitis and non-allergic chronic rhinitis patients, and in control subjects. Methacholine responsiveness was significantly higher in allergic rhinitis patients than in non-allergic patients and control subjects. In perennial rhinitis, methacholine responsiveness correlated with the severity of daily nasal symptoms and those provoked by specific allergen challenge tests. Among nasal symptoms, hyper-rhinorrhoea was found to be closely related to methacholine responsiveness. As a result of these findings, the possibility of cholinergic hyper-reactivity in allergic rhinitis patients is discussed.
D000287:Administration, Topical; D006801:Humans; D008688:Methacholine Compounds / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D009093:Mucus / Q000187:drug effects / Q000378:metabolism; D009299:Nasal Provocation Tests; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000276:immunology; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy* / Q000276:immunology
D008688:Methacholine Compounds