Extracellular potassium accumulation in acute myocardial ischemia.
In acute reversible myocardial ischemia extracellular potassium activity rises 4 to 5 fold within 10 to 15 min after interruption of coronary perfusion. The underlying net cellular K+ loss is likely to be caused by an increased K+ efflux in the presence of maintained Na+/K+ pumping (i.e. active K+ influx). A hypothesis is discussed which relates increased K+ efflux to the formation of weak acids in the cells during anaerobic metabolism. However, the exact mechanism remains to be determined by further experimental investigations.
D000208:Acute Disease; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D003327:Coronary Disease / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism
D000255:Adenosine Triphosphate; D012964:Sodium; D011188:Potassium