title: Prevention of postlaminectomy scar formation.
abstract: An animal experimental study was performed to investigate prevention of scar formation under lumbar laminectomy by using new biodegradable interposing materials-- polylactic acid (PLA) foam and membrane. The experimental animals consisted of 32 dogs, 16 control and 16 experimental. The experimental surgery consisted of L5 or L6 complete laminectomy and covering of the laminectomy defect with the experimental materials. The same procedure but without the covering of the laminectomy defect was performed on the control group animals. Animals were sacrificed at varying intervals (2-52 weeks) and the lumbar spines were evaluated with histologic preparations. The PLA membrane is found to be a promising material for prevention of scar tissue extension and adhesion after laminectomy but has a problem of marginal fitting. PLA foam is found to behave as a scaffold for scar tissue extension and adhesion onto the nerve. Other foamy materials such as gelatin foam or avitane are probably behaving similarly, causing scar tissue extension and adhesion. The new materials were found to be completely biocompatible and slowly biodegradable. A combined use of posteriorly convexed stiff PLA membrane and marginal gap filler with PLA foam may provide solutions for both prevention of scar tissue extension and adhesion and prevention of postlaminectomy spinal stenosis.
mesh_terms: D000818:Animals; D002921:Cicatrix / Q000473:pathology / Q000517:prevention & control*; D004285:Dogs; D007773:Lactates / Q000008:administration & dosage*; D019344:Lactic Acid; D007796:Laminectomy; D008159:Lumbar Vertebrae / Q000473:pathology; D011091:Polyesters; D011108:Polymers / Q000008:administration & dosage*; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control; D013126:Spinal Nerve Roots / Q000473:pathology; D000267:Tissue Adhesions; D014945:Wound Healing / Q000187:drug effects
chemical_list: D007773:Lactates; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide)