Multiple cell origin of traumatically induced keloids.
Six keloids from five patients heterozygous for the X-linked glucose-6-phosphate dehydrogenase (G6PD) locus were studied. Both the B and A enzymes were found in the keloids in similar proportions to the normal tissues. This finding indicates that keloids have a multicellular origin and that they do not develop clonally as do most neoplasms.
D000293:Adolescent; D000328:Adult; D001773:Blood Cells / Q000201:enzymology; D002455:Cell Division; D005260:Female; D005347:Fibroblasts / Q000201:enzymology; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics*; D007627:Keloid / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D012867:Skin / Q000473:pathology
D007527:Isoenzymes; D005954:Glucosephosphate Dehydrogenase