Dermal elastosis in hairless mice after UV-B and UV-A applied simultaneously, separately or sequentially.
The elastosis-inducing capacity of UV-A and UV-B was studied in the skin of hairless mice. After irradiation with UV-B and UV-A applied either simultaneously, separately or sequentially, the degree of elastosis in the dermis was microscopically evaluated. This semi-quantitative method showed no significant elastosis in the UV-A irradiated mice, and moderate elastosis in the UV-B irradiated mice. Heavy elastosis was observed when the mice were exposed sequentially to UV-B and a large dose of UV-A, but if a moderate dose of UV-A was given simultaneously with UV-B, the degree of elastosis was slightly reduced compared with the elastosis induced by UV-B alone.
D000818:Animals; D003240:Connective Tissue Diseases / Q000209:etiology / Q000473:pathology; D004547:Elastic Tissue / Q000473:pathology / Q000528:radiation effects*; D005260:Female; D006965:Hyperplasia / Q000209:etiology; D051379:Mice; D008812:Mice, Hairless; D011829:Radiation Dosage; D012867:Skin / Q000473:pathology / Q000528:radiation effects; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology; D012878:Skin Neoplasms / Q000209:etiology; D014466:Ultraviolet Rays / Q000009:adverse effects*