title: Reduction in noradrenergic perivascular nerve density in the left and right cerebral arteries of old rabbits.
abstract: With the use of fluorescence and acetylcholinesterase histochemistry, marked reductions have been shown in the noradrenergic and acetylcholinesterase-positive innervation of the right ( RMC ) and left (LMC) middle cerebral arteries of old compared with young adult rabbits. The decrease in noradrenergic nerve density tended to be greater in LMC than in RMC : Nerve density fell by approximately 45% in LMC and by approximately 30% in RMC . The reductions in acetylcholinesterase-positive nerves were similar in both LMC and RMC (29 and 33%, respectively). Vessel circumference and cross-sectional wall area appeared to increase in old age in LMC and RMC .
mesh_terms: D000110:Acetylcholinesterase; D000320:Adrenergic Fibers / Q000166:cytology*; D000818:Animals; D002536:Cerebral Arteries / Q000294:innervation*; D006651:Histocytochemistry; D008297:Male; D008856:Microscopy, Fluorescence; D009638:Norepinephrine; D011817:Rabbits
chemical_list: D000110:Acetylcholinesterase; D009638:Norepinephrine