title: Androgen receptor in the human thymus.
abstract: An androgen binding species has been identified in partially purified cytosol from human thymic tissue, resolved from sex steroid binding globulin by gel chromatography. This putative 5 alpha-dihydrotestosterone receptor was characterised by high affinity (Kd 6.7 X 10(-10) M) and low capacity (9 fmol/mg of cytosol protein). High affinity binding was confirmed with methyltrienolone (R1881). Competition studies were carried out with a number of androgenic compounds and 5 alpha-19 nordihydrotestosterone was shown to possess the highest affinity for the androgen receptor.
mesh_terms: D000328:Adult; D000728:Androgens / Q000378:metabolism; D003600:Cytosol / Q000032:analysis; D013196:Dihydrotestosterone / Q000378:metabolism; D006801:Humans; D011944:Receptors, Androgen / Q000032:analysis* / Q000378:metabolism; D011987:Receptors, Steroid / Q000032:analysis*; D013950:Thymus Gland / Q000032:analysis*
chemical_list: D000728:Androgens; D011944:Receptors, Androgen; D011987:Receptors, Steroid; D013196:Dihydrotestosterone