Cadmium and the kidney.
The paper is a review of certain aspects of importance of cadmium and the kidney regarding the assessment of risks and understanding of mechanisms of action. The review discusses the following topics: history and etiology of cadmium-induced kidney dysfunction and related disorders; cadmium metabolism, metallothionein and kidney dysfunction; cadmium in urine as indicator of body burden, exposure and kidney dysfunction; cadmium levels in kidney and liver as indicators of kidney dysfunction; characteristics of early kidney dysfunction; the critical concentration concept; critical concentrations of cadmium in kidney cortex; and prognosis.
D000818:Animals; D001822:Body Burden; D002104:Cadmium / Q000032:analysis / Q000378:metabolism / Q000633:toxicity*; D006801:Humans; D007668:Kidney / Q000032:analysis / Q000187:drug effects*; D007674:Kidney Diseases / Q000139:chemically induced; D008099:Liver / Q000032:analysis; D008668:Metallothionein / Q000378:metabolism; D011379:Prognosis
D002104:Cadmium; D008668:Metallothionein