Acute effects of the synthetic analogue of methionine enkephalin FK 33-824 in schizophrenic patients. A double blind trial.
16 patients with paranoid and hallucinatory symptoms, who were concurrently receiving no other medication, participated in a double blind trial. Either 3 mg FK 33-824 or 20 mg diazepam was injected i.m. over a 2-day period, with a subsequent cross-over for the second medication. Both FK 33-824 and diazepam caused a slight decrease in psychopathological symptoms as measured by the BPRS, but no differences could be observed in their effect on schizophrenic symptoms such as hallucinations and delusions.
D000328:Adult; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006212:Hallucinations / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000188:drug therapy*; D012563:Schizophrenia, Paranoid / Q000188:drug therapy; D012565:Schizophrenic Psychology
D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin