[Pathways of invasion of the lungs by Pseudomonas aeruginosa during burn injury].
P. aeruginosa pneumonia was induced in experiments on rats with stage III-IV thermal burns occupying 18-20% body skin surface. Electron microscopy was used to study the pathways of microorganism invasion from the lungs to the blood. The three main pathways of invasion were discovered: via the dilated intercellular gaps and degenerated basal membrane of the capillary endothelium; via the cytoplasmic channels, and via cell cytoplasm due to incomplete phagocytosis and destruction of macrophages and endotheliocytes. Endocytobiosis of P. aeruginosa in dystrophic pulmonary cells has been demonstrated as one of important factors of the pathogenesis of bacterial invasion.
D000818:Animals; D002056:Burns / Q000150:complications*; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D011552:Pseudomonas Infections / Q000635:transmission*; D051381:Rats; D018805:Sepsis / Q000209:etiology
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