[Role of hyperthyroidism and the fatty component of the diet in changes in the fatty acid composition of the liver mitochondrial lipids in rats].
The influence of hyperthyrosis and the diet fat component on the hepatic mitochondrial fatty-acidic content was studied in Wistar rats. The animals, divided into two groups, were kept within 20 days on synthetic diets enriched with proteins (18%), carbohydrates (56%), fats (26%), vitamin and salt mixtures. The first group of animals was given the butter diet ("B" group) and the second one received the sunflower-seed oil ration ("S" group). It was found that after three weeks from the beginning of the diet the content of hepatic mitochondrial fatty acids was changed according to the fatty-acidic spectrum of alimentary fats. However, the fatty acid unsaturation indices, i.e. the unsaturated fatty acid % X unsaturated bond number, were not different in both mitochondrial populations studied. Hyperthyrosis (induced by 50 micrograms of thyroxin/100 g body weight within 5 successive days intraperitoneally), simulated in the presence of the above diets, not only intensified changes, caused by the diet in the mitochondrial fatty acid content, but induced further variance in the fatty-acidic spectra, being distinctly seen in the "B" group animals. In particular, hyperthyrosis in these animals was accompanied by a fall of linoleic (25%) and arachidonic (36%) acids in the mitochondrial lipid content, being the main cause of decreasing the mitochondrial lipid unsaturation indices by 26%. The alteration of lipid parameters in mitochondria of hyperthyroid animals of the "S" group was less pronounced, being 6%, 11% and 9%, respectively.(ABSTRACT TRUNCATED AT 250 WORDS)
D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage*; D005231:Fatty Acids, Unsaturated / Q000032:analysis / Q000378:metabolism*; D006980:Hyperthyroidism / Q000139:chemically induced / Q000378:metabolism*; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis; D008930:Mitochondria, Liver / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013974:Thyroxine / Q000494:pharmacology
D004041:Dietary Fats; D005231:Fatty Acids, Unsaturated; D008055:Lipids; D013974:Thyroxine
Rol' gipertireoza i zhirovogo komponenta diety v modifikatsiiakh zhirno-kislotnogo sostava lipidov mitokhondriĭ pecheni krysy.