Pharmacokinetics of tetracycline encapsulated in bovine carrier erythrocytes.
Tetracycline was encapsulated in erythrocytes with a dialysis technique. The effect of drug concentration (0.2 mg/ml of erythrocytes) on encapsulation of [14C]sucrose and [3H]tetracycline was reduction of the tetracycline encapsulation, but not [14C]sucrose. Carrier erythrocytes containing tetracycline reinjected in calves were studied for their pharmacokinetic constants. The drug half-life was 6.7 hours, with an overall elimination constant of 0.104 hour-1.
D000818:Animals; D002417:Cattle / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D006207:Half-Life; D007700:Kinetics; D008297:Male; D013395:Sucrose / Q000378:metabolism; D013752:Tetracycline / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
D013395:Sucrose; D013752:Tetracycline