Evaluation of age-specific vaccination strategies.
Under the assumption that maternal antibodies and vaccine immunity decay exponentially the proportions of susceptibles in the total population for given age-specific vaccination strategies and zero infection incidence are determined explicitly. The reciprocal value of such a proportion determines the maximum reproductive rate of an infection which could be eradicated by the corresponding strategy. For a single vaccination during life the optimum age is determined, for which the proportion of susceptibles reaches a minimum. The effect of one revaccination during school age is explored.
D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007113:Immunity, Innate; D007112:Immunity, Maternally-Acquired; D007115:Immunization Schedule; D007223:Infant; D008954:Models, Biological; D014611:Vaccination; D014777:Virus Diseases / Q000276:immunology