Selective induction of glutathione S-transferase D in rat testis by phenobarbital.
Testis cytosol is shown to contain the Yb2Yb2 -homodimer glutathione S-transferase D in addition to the previously described glutathione S-transferases A ( Yb1Yb1 ) and C ( Yb1Yb2 ). Treatment of rats with phenobarbital induces the level of glutathione S-transferase D in testis with no increase in the activities of glutathione S-transferases A and C. This result indicates a specific induction of the Yb2 subunit in testis, in contrast with the situation in rat liver, where phenobarbital specifically induces the Yb1 subunit.
D000818:Animals; D002852:Chromatography, Ion Exchange; D004790:Enzyme Induction / Q000187:drug effects; D005982:Glutathione Transferase / Q000096:biosynthesis*; D007527:Isoenzymes / Q000096:biosynthesis*; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D013737:Testis / Q000187:drug effects / Q000201:enzymology*
D007527:Isoenzymes; D005982:Glutathione Transferase; D010634:Phenobarbital