The carcinogenic effect of 1,1-diethyl-3-methyl-3-nitrosourea in Syrian golden hamsters.
1,1-Diethyl-3-methyl-3-nitrosourea (Et2MNU) was subcutaneously injected in Syrian golden hamsters once weekly for 52 weeks. The animals developed mainly papillomas and squamous cell carcinomas of the nasal cavity and forestomach and hemangioendotheliomas of the spleen. Although survival time and tumour latency showed dose-dependency, tumour incidence did not.
D000284:Administration, Oral; D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D006224:Cricetinae; D004938:Esophageal Neoplasms / Q000139:chemically induced; D005260:Female; D006390:Hemangioendothelioma / Q000139:chemically induced; D007279:Injections, Subcutaneous; D007928:Lethal Dose 50; D008113:Liver Neoplasms / Q000139:chemically induced; D008297:Male; D008647:Mesocricetus; D009369:Neoplasms / Q000139:chemically induced*; D009607:Nitrosourea Compounds / Q000633:toxicity*; D009669:Nose Neoplasms / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced; D013160:Splenic Neoplasms / Q000139:chemically induced; D013274:Stomach Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D009607:Nitrosourea Compounds; C026466:diethylmethylnitrosourea