Regulation of testosterone production in fetal testicular cells: effect of androgens.
Pre-incubation of dispersed testicular cells from 18-day-old mouse fetuses in presence of testosterone or dihydrotestosterone resulted in a significant decrease of the hCG-stimulated testosterone production. These results suggest that during late fetal life testosterone production may be inhibited by an ultra-short loop feedback of androgens.
D000818:Animals; D002478:Cells, Cultured; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D013196:Dihydrotestosterone / Q000494:pharmacology; D008297:Male; D051379:Mice; D013737:Testis / Q000196:embryology* / Q000378:metabolism; D013739:Testosterone / Q000096:biosynthesis* / Q000494:pharmacology
D006063:Chorionic Gonadotropin; D013196:Dihydrotestosterone; D013739:Testosterone