A sensitive human thyroglobulin RIA to define clearly the presence or absence of functioning thyroid tissue.
This paper describes a practical procedure to establish a sensitive radioimmunoassay for the measurement of human thyroglobulin (HTg) in serum. The assay enables a clear distinction to be made between levels of HTg indicating the presence or absence of functioning thyroid tissue. It compares the use of HTg serum levels with the conventional I-131 scintigram as a marker for recurrent thyroid cancer. In addition, a simple and sensitive radioimmunologic assay is described for the determination of serum antithyroglobulin autoantibodies, the presence of which may give falsely elevated HTg levels.
D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D011877:Radionuclide Imaging; D012016:Reference Values; D013954:Thyroglobulin / Q000097:blood* / Q000276:immunology; D013964:Thyroid Neoplasms / Q000097:blood* / Q000000981:diagnostic imaging / Q000601:surgery; D013965:Thyroidectomy
D001323:Autoantibodies; D007457:Iodine Radioisotopes; D013954:Thyroglobulin