title: The photodynamic effect of chlorpromazine, promazine, and hematoporphyrin on lens protein.
abstract: Calf lens protein was irradiated with near ultraviolet (UV) light in the presence of the drugs chlorpromazine, promazine, and hematoporphyrin. It then was analyzed by SDS-polyacrylamide gel electrophoresis and amino acid analysis. Marked increases in protein photopolymerization (other than S-S bond formation) and histidine destruction were noted in the presence of these drugs. In all cases, these effects were reduced in the presence of a singlet oxygen quencher, thus suggesting that these photodynamic effects are due, at least in part, to a Type II mechanism.
mesh_terms: D002746:Chlorpromazine / Q000494:pharmacology*; D003459:Crystallins / Q000032:analysis*; D006415:Hematoporphyrins / Q000494:pharmacology*; D008027:Light; D010782:Photolysis; D011395:Promazine / Q000494:pharmacology*
chemical_list: D003459:Crystallins; D006415:Hematoporphyrins; D011395:Promazine; D002746:Chlorpromazine