Transient seizure activity induced by acetylcarnitine.
Intracerebral injection of L-acetylcarnitine in rats induced interictal and ictal epileptic phenomena with immediate onset, lasting up to 4 h. Pretreatment with systemic atropine prevents all epileptiform phenomena. Local injection of muscimol and THIP abolish ictal events, but not single spikes. L-carnitine induced only ictal discharges with a latency of 40-90 min. Acetylcarnitine epileptogenic properties are probably related to muscarinic agonism. The transition from interictal to ictal events may involve failure of GABAergic mechanisms.
D000108:Acetylcarnitine / Q000494:pharmacology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002331:Carnitine / Q000031:analogs & derivatives*; D002540:Cerebral Cortex; D004569:Electroencephalography; D008032:Limbic System; D008297:Male; D010275:Parasympathetic Nervous System / Q000502:physiology*; D051381:Rats; D012640:Seizures / Q000139:chemically induced*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D005680:gamma-Aminobutyric Acid; D000108:Acetylcarnitine; D001285:Atropine; D002331:Carnitine