[Cardiotoxicity of strophanthin for rats and its correction with anaprilin in coronary-related and non-coronary-related damage to the myocardium and acute cardiac insufficiency].
It has been shown in rat experiments that non-coronarogenic injury to the myocardium induced by isadrin reduces the tolerance to the cardiotoxic action of strophanthine more powerfully than coronary artery occlusion. The physical overloading until complete exhaustion induced by swimming raises the cardiotoxicity of strophanthine to the same degree as non-coronarogenic injury to the myocardium. Hypersensitivity to strophanthine is successfully corrected by the beta-adrenoblocker anaprilin.
D000818:Animals; D009202:Cardiomyopathies / Q000503:physiopathology*; D003327:Coronary Disease / Q000503:physiopathology*; D004361:Drug Tolerance; D005260:Female; D006321:Heart / Q000187:drug effects; D006333:Heart Failure / Q000503:physiopathology*; D005082:Physical Exertion; D051381:Rats; D011919:Rats, Inbred Strains; D013328:Strophanthins / Q000037:antagonists & inhibitors / Q000633:toxicity*
D013328:Strophanthins
Kardiotoksichnost' strofantina dlia krys i ee korrektsiia anaprilinom pri koronarogennom i nekoronarogennom porazhenii miokarda i ostroĭ serdechnoĭ nedostatochnosti.