[Use of multicellular spheroids in studies based on the NSD (nominal standard dose) concept].
The authors discuss the possibility of application of multicellular spheroids as a model system in studies based on NSD conception. The death rate of spheroids from cells of Chinese hamster V79-4 was shown to depend upon cumulative dose of gamma- and neutron (0.7 MeV)-radiation (the number of fractions was 1, 5 and 10). With fractionated irradiation, the reoxygenation effect was observed. A good coincidence was obtained between the dependence of the cumulative dose upon the number of fractions for multicellular spheroids and clinical data.
D000818:Animals; D002470:Cell Survival / Q000528:radiation effects*; D006224:Cricetinae; D003412:Cricetulus; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D009369:Neoplasms / Q000532:radiotherapy*; D010100:Oxygen / Q000528:radiation effects; D010101:Oxygen Consumption; D011879:Radiotherapy Dosage
D010100:Oxygen
Ispol'zovanie mnogokletochnykh sferoidov v issledovaniiakh po kontseptsii NSD.