Resistance to the mitotic inhibitor NY 3170 in Chinese hamster ovary cells.
Mutant CHO cells have been isolated which are resistant to NY 3170, a member of the metahalone group of antimitotic drugs. One NY 3170 resistant mutant is hypersensitive to the microtubule-stabilising drug, taxol, but there is not a reciprocal relationship between levels of resistance to these drugs in CHO cells, since it was found that sixteen other mutants isolated on the basis of taxol resistance had wild type levels of NY 3170 resistance. Our NY 3170 resistant mutants are cross-resistant to vincristine and other mutants, selected on the basis of vincristine resistance, are cross-resistant to NY 3170.
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D004351:Drug Resistance; D005260:Female; D007700:Kinetics; D008938:Mitosis / Q000187:drug effects*; D009154:Mutation; D010053:Ovary; D011744:Pyrimidinones / Q000633:toxicity*; D013329:Structure-Activity Relationship
D011744:Pyrimidinones; C021131:1-propargyl-5-chloropyrimidin-2-one