Tumor promoting activity of Euphorbia striatella (Boiss) and skin irritant activity of some Euphorbia species.
Out of seven plants selected due to their use in folk medicine, five possessing ingenol as diterpene parent, exhibited mild skin irritancy where as E. striatella latex was highly skin irritant and produced papilloma, in initiation-promotion experiment on mouse back skin. This tumor promoting activity has been demonstrated due to the presence of ingenol-3-O-decanoate.
D000818:Animals; D002273:Carcinogens / Q000302:isolation & purification*; D004224:Diterpenes / Q000302:isolation & purification*; D007509:Irritants; D051379:Mice; D008815:Mice, Inbred Strains; D010946:Plants, Medicinal / Q000032:analysis*; D012867:Skin / Q000187:drug effects
D002273:Carcinogens; D004224:Diterpenes; D007509:Irritants; C008125:ingenol