Ocular delivery of pilocarpine from erodible matrices.
The present study examined the feasibility of sustaining the release of a water-soluble drug, pilocarpine, to the tear film. Both gels and dried films were utilized as drug delivery systems. In vitro studies demonstrated significant prolongation of drug release from these systems as compared with simple aqueous or viscous solutions. The in vitro results were supported by in vivo miosis studies in albino rabbits.
D000818:Animals; D005782:Gels; D008297:Male; D008540:Meiosis / Q000187:drug effects; D009883:Ophthalmic Solutions; D010862:Pilocarpine / Q000008:administration & dosage* / Q000494:pharmacology; D011108:Polymers; D011142:Polyvinyl Alcohol; D011817:Rabbits; D012995:Solubility
D005782:Gels; D009883:Ophthalmic Solutions; D011108:Polymers; D010862:Pilocarpine; D011142:Polyvinyl Alcohol