Abnormal lactate dehydrogenase isoenzyme pattern in a critically ill patient.
We have described a patient who had an abnormal isoenzyme of lactate dehydrogenase in both serum and tissue. The presence of LD6 is indicative of a poor prognosis. Some of the biochemical characteristics of the isoenzyme are (1) LD6 is not an artifact, (2) it contains an M subunit but not an H subunit, and (3) it is not an immunoglobulin complex. We believe LD6 may arise during episodes of severe shock as lysosomes rupture and is either a previously sequestered lysosomal LD or is a lysosomal modification of LD5.
D000138:Acidosis / Q000201:enzymology; D004587:Electrophoresis, Agar Gel; D006801:Humans; D007239:Infections / Q000201:enzymology; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000032:analysis*; D008099:Liver / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000201:enzymology; D011379:Prognosis; D012769:Shock / Q000201:enzymology*
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase