Hypertension after clonidine overdose. A case report.
A hypertensive reaction is described in a 28-year-old woman with renal failure who took 30-70 clonidine tablets (150 micrograms each) with suicidal intent. She became increasingly drowsy. Her blood pressure on admission was 210/150 mmHg and gradually fell to 140/100 mmHg during the next 16 hours, at which time her plasma clonidine concentration was 4.7 ng/ml. This interesting hypertensive reaction was probably due to excessive stimulation of peripheral postsynaptic alpha-adrenoceptors.
D000328:Adult; D003000:Clonidine / Q000097:blood / Q000506:poisoning*; D005260:Female; D005921:Glomerulonephritis / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D013406:Suicide, Attempted
D003000:Clonidine