Translocation 1;7 in dyshematopoiesis: possibly induced with a nonrandom geographic distribution.
Eight patients with various hematologic disorders had an identical chromosomal aberration in their bone marrow or unstimulated peripheral blood, a translocation t(1;7) interpreted as t(1;7)(p11;p11). The translocation chromosome replaced one normal chromosome #7; therefore, the karyotype of the abnormal cells was trisomic for 1q and monosomic for 7q. Including four cases from the literature, a total of 12 patients (4 women, 8 men) with this translocation are known at the moment. The translocation does not seem to be associated with a specific disorder, but almost all patients had a preleukemic syndrome during some stage of their disease. It is very remarkable that 11 of the 12 patients lived in the Netherlands, and 7 patients had a history of iatrogenic exposure to alkylating agents or irradiation; one patient was a radiation worker and another one had a history of toxic exposure to chloramphenicol. It is suggested, therefore, that the t(1;7) is a possibly induced chromosomal aberration with a clearly nonrandom geographic distribution.
D000328:Adult; D000368:Aged; D000477:Alkylating Agents / Q000009:adverse effects; D002900:Chromosomes, Human, 1-3; D002906:Chromosomes, Human, 6-12 and X; D005260:Female; D006402:Hematologic Diseases / Q000453:epidemiology / Q000209:etiology / Q000235:genetics*; D006801:Humans; D007938:Leukemia / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009426:Netherlands; D010051:Ovarian Neoplasms / Q000235:genetics; D011086:Polycythemia / Q000235:genetics; D011289:Preleukemia / Q000235:genetics; D011832:Radiation Injuries / Q000150:complications; D014178:Translocation, Genetic; D014314:Trisomy
D000477:Alkylating Agents