Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor.
The nucleotide sequence of a transforming human c-sis complementary DNA shows an open reading frame 723 base pairs in length located downstream from an in-phase terminator thymine-guanine-adenine codon. Sequences within this region were identical to those previously determined for the exons of the normal human c-sis gene. Thus, the predicted transforming product, a protein of 27,281 daltons, may be the actual precursor for normal human platelet-derived growth factor chain A.
D000818:Animals; D001483:Base Sequence; D002427:Cebidae; D002471:Cell Transformation, Neoplastic / Q000378:metabolism*; D003062:Codon; D004273:DNA, Neoplasm / Q000235:genetics; D006801:Humans; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D010982:Platelet-Derived Growth Factor / Q000235:genetics*
D003062:Codon; D004273:DNA, Neoplasm; D010982:Platelet-Derived Growth Factor