Theophylline precipitated alterations of lithium clearance.
The effect of steady state therapeutic theophylline serum levels on lithium clearance was investigated. A significant increase in lithium clearance occurred with the administration of theophylline. Despite considerable intersubject variability, a direct lithium clearance estimation method demonstrated a mean increase of 30% with the addition of theophylline. The concomitant use of lithium and theophylline potentially may alter lithium levels sufficiently to result in manic or depressive relapses in patients receiving lithium prophylactically.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007700:Kinetics; D008094:Lithium / Q000097:blood / Q000378:metabolism*; D008297:Male; D013806:Theophylline / Q000097:blood / Q000494:pharmacology*
D008094:Lithium; D013806:Theophylline