Inheritance of maternal immunoglobulin G1 concentration by the bovine neonate.
Serum samples were collected between 24 and 48 h of age from 408 Herefored calves of a Selection Experiment and from 200 Angus, Hereford and Red Poll calves of another experimental population (Germ Plasm Utilization Project). Concentrations of immunoglobulin G1 (IgG1) were determined by single radial immunodiffusion. Breed or selection line of calf and age of dam were the most important factors influencing IgG1 concentrations (P less than .01). In the Germ Plasm Utilization (GPU) herd, Angus calves were highest, Red Polls were intermediate and Herefords were lowest in serum concentrations. Calves from Hereford lines selected for weaning weight, yearling weight or an index based on yearling weight and muscling score were lower in IgG1 concentration than calves from the randomly selected control line. In both populations immunoglobulin levels in the calf increased as age of dam increased. In Selection Experiment Herefords, increased calving difficulty was associated with a decrease in calf IgG1 levels (P less than .05). Heritabilities of calf serum IgG1 concentration, estimated from paternal half-sib analysis on a within line or breed basis, were .03 +/- .09 and .13 +/- .19 in the two populations. In the Selection Experiment Herefords, when the component of variance for selection line was added both to the numerator and denominator of heritability, the revised estimate was .09 +/- .09. Heritabilities of maternal effects on IgG1 concentration were also estimated (by nesting calves within maternal grandsires) on a within line or breed basis. These heritabilities were .23 +/- .17 and -.07 +/- .27 for the Selection Experiment and GPU populations, respectively. In the Selection Experiment population, when the variance component for selection line was added to the numerator and denominator of maternal effects heritability, the estimate was .27 +/- . .17. Those calves that died had a lower mean IgG1 concentration than the population average (P less than .01).
D000818:Animals; D000831:Animals, Newborn / Q000235:genetics* / Q000276:immunology; D001835:Body Weight; D001947:Breeding; D002417:Cattle / Q000235:genetics* / Q000276:immunology; D005260:Female; D007074:Immunoglobulin G / Q000032:analysis / Q000235:genetics*; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012641:Selection, Genetic
D007074:Immunoglobulin G