Diagnostic insonation of extra utero human placentas: no effect of lymphocytic sister chromatid exchange.
Freshly delivered human placentas were exposed to ultrasound for 30 min using a diagnostic linear array unit. Blood was then drawn and cultured in the presence of bromodeoxyuridine, and the frequencies of sister chromatid exchanges (SCE) in the lymphocytes determined. There was no statistically significant difference in SCE frequencies between control and exposed cells; the frequencies of SCEs per cell ranged from 4.50 to 6.02 for control and from 4.66 to 6.10 for exposed cells in five separate experiments. Positive control mitomycin C treated cells were significantly affected, with more than 50 SCEs per cell.
D003434:Crossing Over, Genetic; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000648:ultrastructure; D010920:Placenta / Q000648:ultrastructure*; D012854:Sister Chromatid Exchange; D013010:Sonication / Q000009:adverse effects*; D014465:Ultrasonics / Q000009:adverse effects*