[Effect of droperidol, fentanyl and talamonal on the ischemic threshold of the myocardium].
The authors studied the effects of neuroleptoanalgetics on the myocardial ischemia threshold in conscious rabbits. Droperidol and talamonal were capable of raising the myocardial tolerance to ischemia. However, the myocardial tolerance to ischemia diminished as the drug doses were raised. The narcotic analgetic phentanyl (0.1 microgram/kg) did not change the myocardial ischemia threshold. The tendency toward the lowering of the myocardial tolerance to ischemia was noted after administration of higher doses of phentanyl.
D000818:Animals; D003327:Coronary Disease / Q000503:physiopathology*; D004329:Droperidol / Q000009:adverse effects*; D004338:Drug Combinations / Q000009:adverse effects; D005260:Female; D005283:Fentanyl / Q000009:adverse effects*; D006321:Heart / Q000187:drug effects*; D008297:Male; D009458:Neuroleptanalgesia / Q000009:adverse effects*; D011817:Rabbits
D004338:Drug Combinations; C001451:Innovar; D004329:Droperidol; D005283:Fentanyl
Vliianie droperidola, fentanila i talamonala na porog ishemii miokarda.