A stochastic approach to tracer kinetics.
The single compartment well-mixed model ( SCWMM ) which has been used in almost all dynamic studies in nuclear medicine is, in fact , strictly accurate only in the case of a steady state obtained by means of constant administration of long-lived isotopes. That is the reason why SCWMM is not a good predictor of the behaviour of short-lived isotopes and why the distribution and transport of short- and long-lived isotopes in various situations has not yet been discussed in general terms. The aim of this paper is to do that by means of a more general stochastic approach. This more general approach takes into account the distribution and transport of tracer in the system, not requiring a hypothesis of good mixing and providing a possibility of making corrections due to decay in the case of short-lived isotopes studies.
D006207:Half-Life; D006801:Humans; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007700:Kinetics; D008433:Mathematics; D011849:Radioactive Tracers; D011868:Radioisotopes
D011849:Radioactive Tracers; D011868:Radioisotopes