title: Midline malignant reticulosis.
abstract: A combined histological, ultrastructural and cytological study was performed on biopsy materials from nasal lesions of 2 patients with midline granuloma. The histological and ultrastructural features of the tissues were necrosis, inflammation and infiltration of atypical histiocytic cells. The DNA-content of these histiocytes exceeded the limits of the 5c Exceeding-Rate and the 2c Deviation Index. The morphological characteristics and the results of the DNA-cytophotometry classify the midline granuloma as a local malignant histiocytosis. Clinical follow-up of the cases suggests that radiation therapy offers a good prospect of treatment success.
mesh_terms: D000328:Adult; D001706:Biopsy; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D005434:Flow Cytometry; D006103:Granuloma, Lethal Midline / Q000473:pathology* / Q000532:radiotherapy; D006644:Histiocytes / Q000648:ultrastructure*; D006801:Humans; D008206:Lymphatic Diseases; D008875:Middle Aged; D009666:Nose / Q000473:pathology* / Q000648:ultrastructure; D009669:Nose Neoplasms / Q000473:pathology
chemical_list: D003037:Cobalt Radioisotopes