Synthesis and biological evaluation of radiolabeled beta-ruthenocenylalanine.
Carrier-free beta-[103,106Ru] ruthenocenylalanine was prepared from 103, 106RuCl3 by utilizing ( ruthenocenylmethyl )trimethylammonium iodide as the key synthetic intermediate. The amino acid analogue was evaluated as a pancreatic imaging agent, but no selective uptake in the pancreas was observed in either rats or mice.
D000409:Alanine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D009942:Organometallic Compounds; D010179:Pancreas / Q000000981:diagnostic imaging; D011877:Radionuclide Imaging; D051381:Rats; D011916:Rats, Inbred F344; D012428:Ruthenium / Q000138:chemical synthesis* / Q000494:pharmacology
D009942:Organometallic Compounds; D012428:Ruthenium; C041497:beta-ruthenocenylalanine; D000409:Alanine