Naloxone-induced augmentation of the photically evoked afterdischarge in conscious rats.
Naloxone, at subconvulsive dose levels, from 1 to 15 mg/kg were administered to conscious rats. Significant increases in photically evoked afterdischarge occurrence were seen at naloxone dose levels above 5 mg/kg with no clinical evidence of seizure activity being observed. Typically photically evoked afterdischarge augmentation is only observed following the administration of convulsive drugs.
D000818:Animals; D003292:Convulsants / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D013268:Stimulation, Chemical; D014793:Visual Cortex / Q000187:drug effects*
D003292:Convulsants; D009270:Naloxone