Clinical and pharmacological considerations in elimination of tricyclic antidepressants and metabolites after overdose.
Elimination of amitriptyline and/or metabolite after overdoses may be delayed because of impaired metabolism. A case is described where this was possibly related to hepatotoxicity. Metabolite concentrations, including 10-OH-derivatives, were highly elevated. The biological properties and clinical significance of these metabolites merit further study.
D000328:Adult; D000639:Amitriptyline / Q000378:metabolism / Q000506:poisoning; D000929:Antidepressive Agents, Tricyclic / Q000378:metabolism / Q000506:poisoning*; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology; D005260:Female; D006801:Humans; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D008111:Liver Function Tests; D013997:Time Factors
D000929:Antidepressive Agents, Tricyclic; D000639:Amitriptyline