Propafenone disposition kinetics in cardiac arrhythmia.
Propafenone disposition kinetics were studied after intravenous and oral doses in patients with ventricular arrhythmias. Plasma concentration-time data were fit to a two-compartment model for all but one patient, whose data required fitting to a three-compartment model. The model-independent calculated values of clearance, steady-state volume of distribution, and terminal t1/2 were 11.2 +/- 4.8 ml/min/kg, 3.6 +/- 2.1 l/kg, and 5.0 +/- 3.6 hr. After 5 days on oral propafenone, elimination t1/2 was 6.2 +/- 3.3 hr. The longer t1/2s and the estimates of steady-state bioavailability above 100% suggests that clearance decreases during chronic oral dosing. Considerable intersubject variability was noted in all disposition parameters.
D000328:Adult; D000368:Aged; D000889:Anti-Arrhythmia Agents / Q000378:metabolism*; D001145:Arrhythmias, Cardiac / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D011405:Propafenone; D011427:Propiophenones / Q000378:metabolism*
D000889:Anti-Arrhythmia Agents; D011427:Propiophenones; D011405:Propafenone