title: Anti-neoplastic activity of C205: a new topical anti-cancer formulation.
abstract: C205, a topical ointment currently in clinical trial, was tested by a method developed to evaluate the topical activity of new drugs. Subcutaneous B-16 melanoma was used as the primary tumor model. Tumor size of treated animals as percentage of tumor size of control animals (T/C ratio) was found to be 14, with 50% of the animals tested free of viable and palpable tumor at 60 days post treatment. The anti-neoplastic activity of C205 was superior to 5-fluorouracil using the same method of evaluation. Only minimal loss of animal body weight occurred after C205. C205 also showed anti-tumor activity against subcutaneously implanted Lewis lung carcinoma.
mesh_terms: D000166:Acridines / Q000008:administration & dosage / Q000494:pharmacology*; D000287:Administration, Topical; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage; D004353:Drug Evaluation, Preclinical; D008175:Lung Neoplasms; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D012878:Skin Neoplasms / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000166:Acridines; D000970:Antineoplastic Agents; C042111:C 205