title: Organic acid transport to the blood from the corpus striatum, the thalamus and the cerebellum of the rat.
abstract: Conscious rats were given intracerebral injections by preplaced microsyringes. The injectates were 0.3-0.5 microliters of 125I- and 131I-o-iodohippurate. One hour after injection the isotopes present in the unopened cranial cavity were measured by gamma spectrometry. Some animals received 200 mg/kg probenecid intraperitoneally and this reduced the rate of absorption from injectates into the corpus striatum to 65.7 +/- 12.6% of control; from injectates into the cerebellum to 57.1 +/- 9.8% of control. Dye injections showed that injections into the cerebellum did not remain in the parenchyma, in contrast to injections into the corpus striatum or thalamus. Probenecid was also given as 2.9% solution, pH 7, mixed with the iodohippurate in the microsyringe. It had no effect on injections into the cerebellum, reduced the rate of absorption from the corpus striatum to 80.9 +/- 3.2% of controls and that from the thalamus to 88.3 +/- 2.2%. The results indicate parenchymal probenecid-sensitive transport of iodohippurate from the corpus striatum and thalamus but failed to settle the matter for the cerebellum.
mesh_terms: D000042:Absorption; D000818:Animals; D001692:Biological Transport; D002531:Cerebellum / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism*; D007465:Iodohippuric Acid / Q000378:metabolism*; D008297:Male; D011339:Probenecid / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013788:Thalamus / Q000378:metabolism*
chemical_list: D007465:Iodohippuric Acid; D011339:Probenecid