Effect of a protein-free haemodialysate on tissue respiration and healing of burns.
Investigations were carried out in three groups of rats (10 rats per group) sustaining partial skin thickness burns covering 2.2 per cent of body surface area. Thirty minutes after burning animals received: Group I, 1 ml Solcoseryl, IP; Group II, 1 ml normal saline, IP; Group III, no treatment (controls). Two hours after burning tissue respiration and the tissue concentrations of potassium, magnesium, calcium and sodium ions were measured in biopsies from the burn wounds. It was found that early post-burn administration of Solcoseryl significantly inhibited the secondary destructive processes and accelerated the regeneration of damaged tissue.
D000183:Actihaemyl / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D002056:Burns / Q000378:metabolism / Q000473:pathology / Q000628:therapy*; D004573:Electrolytes / Q000378:metabolism; D005260:Female; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012867:Skin / Q000378:metabolism / Q000473:pathology; D014020:Tissue Extracts / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
D004573:Electrolytes; D014020:Tissue Extracts; D000183:Actihaemyl