Noninvolvement of histamine and prostaglandins in the dermatosis of magnesium-deficient hairless rats.
Hairless rats receiving a deprived Mg2+ diet developed long-lasting inflammatory dermatosis which was not influenced by treatments with mepyramine, cimetidine, aspirin or indomethacin. Dermatosis did not appear in deprived rats treated with intraperitoneal injections of Mg2+, or with dexamethasone. Histamine and prostaglandins did not seem to be involved in this dermatosis. The possible role of leucotrienes is discussed.
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D006632:Histamine / Q000032:analysis / Q000502:physiology*; D007249:Inflammation / Q000378:metabolism; D008275:Magnesium Deficiency / Q000378:metabolism*; D011453:Prostaglandins / Q000032:analysis / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012871:Skin Diseases / Q000378:metabolism*; D014018:Tissue Distribution
D011453:Prostaglandins; D003907:Dexamethasone; D006632:Histamine