Investigations on the detection of mutagenic activity of beef extract in rats after oral administration.
After oral administration of beef extract the body fluids of Aroclor-treated and untreated rats were investigated for mutagenicity using the Salmonella/microsome test. In the stomach contents, the bile and the urine of the animals, mutagenic activity was discovered after S-9 activation. Although the mutagenic substances must have been transported by the blood stream to the excreting organs no increased mutagen-induced his+ revertants were observed in venous blood. Direct-acting mutagens were not detected in the tested body fluids, either in the Aroclor-treated rats or in the untreated ones.
D000284:Administration, Oral; D000818:Animals; D001140:Aroclors / Q000633:toxicity; D001646:Bile / Q000378:metabolism; D001711:Biotransformation; D002417:Cattle; D008297:Male; D008460:Meat / Q000633:toxicity*; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000097:blood / Q000652:urine; D051381:Rats; D013997:Time Factors; D014020:Tissue Extracts / Q000633:toxicity*
D001140:Aroclors; D009153:Mutagens; D014020:Tissue Extracts