[Effect of inhibitors of prostaglandin biosynthesis on mouse resistance to cooling: fact and hypothesis].
Prostaglandin (PG) biosynthesis inhibitors increase the resistance of mice to cold in acute experiments when administered 30-90 min before cooling in the doses that are sufficient for the attainment of PG synthesis inhibition. It is suggested that the so-called "permissive" effect on the catecholaminergic mechanisms of cold defence underlies the protective effect of PG synthesis inhibitors. The effect under consideration is similar to the known "permissive" effect of corticosteroids, the mechanism of which may be therefore identified presumably as the blockade of PG biosynthesis or action.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D003080:Cold Temperature; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013696:Temperature; D013997:Time Factors
D011448:Prostaglandin Antagonists
Vliianie ingibitorov biosinteza prostaglandinov na ustoĭchivost' mysheĭ k okhlazhdeniiu: fakt i gipoteza.