Cimetidine prophylaxis after renal transplantation.
Over an 18 month period 66 consecutive kidney transplant patients at risk of gastrointestinal bleeding were treated prophylactically with the histamine H2-blocker cimetidine, without antacids. The incidence of gastrointestinal bleeding, the number of rejection episodes, and graft survival were compared with those of 66 patients, who had received a transplant in the period immediately preceding the start of the study, and who had never received cimetidine. The incidence of gastrointestinal hemorrhage was significantly reduced in the cimetidine-treated patients (P less than 0.05). In addition, cimetidine treatment neither increased the total number of rejection episodes nor did it impair long-term graft survival.
D000328:Adult; D002927:Cimetidine / Q000627:therapeutic use*; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000517:prevention & control*; D006084:Graft Rejection / Q000187:drug effects; D006085:Graft Survival / Q000187:drug effects; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D016030:Kidney Transplantation; D008297:Male; D012189:Retrospective Studies
D006146:Guanidines; D002927:Cimetidine