In vitro stability of sodium nitroprusside solutions for intravenous administration.
A sensitive high-performance liquid chromatographic assay for nitroprusside using an ion-exchange column and UV detection was developed to evaluate the stability of aqueous solutions of sodium nitroprusside in light-protected glass and plastic containers and during simulated infusions. The results showed that sodium nitroprusside is stable in 5% dextrose, normal saline, and lactated Ringer's solutions in light-protected glass or plastic containers. In addition, there was no decrease in the delivered potency of sodium nitroprusside solutions during simulated infusions lasting up to 24 h.
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004349:Drug Packaging; D004355:Drug Stability; D005292:Ferricyanides / Q000032:analysis*; D007263:Infusions, Parenteral; D009599:Nitroprusside / Q000032:analysis*; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet / Q000379:methods; D013997:Time Factors
D005292:Ferricyanides; D012996:Solutions; D009599:Nitroprusside