Amikacin levels in the human biliary tract.
The concentrations of amikacin in serum, gallbladder, and common duct bile, and gallbladder tissue in patients undergoing surgery of the biliary tract were investigated. Patients received 500 mg amikacin intravenously or intramuscularly from 1 to 11 hours before surgery. Another group had T-tubes inserted and blood and bile levels were studied serially postoperatively. One half hour after 500 mg amikacin, serum levels were high and bile levels were 30 per cent of the serum levels, with tissue levels less than 19 per cent of the serum levels. At 6 hours, serum levels were 37 per cent of the 1-hour levels; however, bile levels were 34 per cent of the simultaneous serum levels. At 11 hours, both postdose serum and bile amikacin levels were low. However, simultaneous bile levels were higher than serum levels. No patient suffered from any side effects from amikacin.
D000328:Adult; D000368:Aged; D000583:Amikacin / Q000008:administration & dosage / Q000378:metabolism*; D001646:Bile / Q000378:metabolism / Q000382:microbiology; D001659:Biliary Tract / Q000378:metabolism*; D001826:Body Fluids / Q000378:metabolism; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007273:Injections, Intramuscular; D007612:Kanamycin / Q000031:analogs & derivatives*; D007700:Kinetics; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged
D007612:Kanamycin; D000583:Amikacin