Suppression of renal sympathetic activity with potassium supplement in DOCA-salt rats.
We studied the involvement of renal sympathetic nervous system activity in the antihypertensive and natriuretic effects of potassium supplement in DOCA-salt treated rats. Systolic blood pressure of DOCA-salt rats rose substantially, reaching 181 +/- 3 mmHg after 4 weeks of DOCA-salt administration. In contrast, the supplement of 1% KCl solution attenuated the development of the hypertension until the fourth week (120 +/- 1 mmHg). After the 4-week treatments, renal norepinephrine turnover rate was calculated from the decline in specific activity after the injection of dl-3H-norepinephrine. It was markedly accelerated in DOCA-salt rats as compared to control rats. In contrast, 1% KCl supplement significantly restored to normal the increased renal norepinephrine turnover rate in DOCA-salt rats. Taken together, evidence presented suggests that the normalization of the increased renal sympathetic tone may be involved in the natriuretic and antihypertensive effects of potassium supplement in DOCA-salt hypertensive rats.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight; D003900:Desoxycorticosterone / Q000494:pharmacology*; D005470:Fluorometry; D005527:Food, Fortified; D006973:Hypertension / Q000517:prevention & control; D066298:In Vitro Techniques; D007668:Kidney / Q000294:innervation*; D008297:Male; D009318:Natriuresis / Q000187:drug effects; D009638:Norepinephrine / Q000032:analysis / Q000378:metabolism; D011188:Potassium / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013564:Sympathetic Nervous System / Q000187:drug effects*; D013997:Time Factors; D014316:Tritium
D014316:Tritium; D003900:Desoxycorticosterone; D011188:Potassium; D009638:Norepinephrine