The use of directly compressible vehicles for the preparation of vitamin B1 tablets.
The classical method for the preparation of vitamin B1 tablets led to tablets of doubtful and/or shorter stability. Dipac , Emdex , Nu-Tab and Sugartab , were evaluated as direct compression vehicles for the preparation of vitamin B1 tablets. Avicel was also employed as a traditional vehicle for comparison. These vehicles were evaluated at different concentrations compared with vitamin B1 tablets available in the Egyptian market and prepared by the classical method. Generally, it was found that increasing the concentration of the vehicles in the tested vitamin B1 formulations improved the physical standards and mechanical strength of the tablets produced. Avicel was found to be the most suitable vehicle, followed by Dipac and Emdex . However, Sugartab and Nu-Tab were found to be the worst in this respect.
D004339:Drug Compounding; D006245:Hardness Tests; D014677:Pharmaceutical Vehicles; D011312:Pressure; D012995:Solubility; D013607:Tablets; D013831:Thiamine / Q000008:administration & dosage*
D014677:Pharmaceutical Vehicles; D013607:Tablets; D013831:Thiamine