Effects of drug and chemical pretreatments on biliary excretion of phenylcyclohexene in the rat.
The biliary excretion of 14C-phenylcyclohexene and its metabolites were studied in rats pretreated with an inducer or inhibitor of mixed-function oxidases or with an agent known to deplete liver glutathione. Pretreatment of rats with 3-methylcholanthrene or phenobarbital enhanced the biliary excretion of 14C-phenylcyclohexene and/or its metabolites. Conversely, pretreatment of rats with SKF-525A or piperonyl butoxide decreased the biliary excretion of 14C-phenylcyclohexene and/or its metabolites. In contrast, pretreatment of rats with diethylmaleate did not alter significantly the rate of biliary excretion of radioactivity.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D003510:Cyclohexanes / Q000378:metabolism*; D004790:Enzyme Induction / Q000187:drug effects; D005978:Glutathione / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008298:Maleates / Q000494:pharmacology; D008748:Methylcholanthrene / Q000494:pharmacology; D006899:Mixed Function Oxygenases / Q000378:metabolism; D010634:Phenobarbital / Q000494:pharmacology; D010882:Piperonyl Butoxide / Q000494:pharmacology; D011335:Proadifen / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D003510:Cyclohexanes; D008298:Maleates; D008748:Methylcholanthrene; C034672:1-phenylcyclohex-1-ene; D011335:Proadifen; D006899:Mixed Function Oxygenases; C014476:diethyl maleate; D005978:Glutathione; D010882:Piperonyl Butoxide; D010634:Phenobarbital