Alterations in gastric acid secretion following hepatic portal injections of D-glucose and its anomers.
Changes in acid outputs from the stomach were examined after portal injections of D-glucose and its optical anomers in the bilaterally adrenalectomized rats with insulin hypoglycaemia. Significant decrease in gastric acid outputs was noted after portal injections of alpha-D-glucose, optically equilibrated D-glucose (OEDG) consisting of 36% alpha-anomer and 64% beta-anomer and beta-D-glucose. The effect of beta-D-glucose was most potent in reducing the acid outputs and the inhibitory response was entirely prevented by prior vagotomy at the hepatic level. The injections of isotonic NaCl solution, however, produced no change in the acid outputs. Results suggest that changes in glucose levels in the portal vein may modulate gastric acid secretion through hepatic vagal afferents and gastric vagal efferents and suggest that activation of hepatic glucosensitive mechanisms may be dependent on the anomeric stereospecificity of D-glucose in the blood.
D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005744:Gastric Acid / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology; D008099:Liver / Q000294:innervation; D008297:Male; D011169:Portal Vein; D051381:Rats; D013237:Stereoisomerism; D013270:Stomach / Q000294:innervation; D014630:Vagus Nerve / Q000187:drug effects
D003837:Deoxy Sugars; D007328:Insulin; D003847:Deoxyglucose