RNA polymerase III control regions in retrovirus LTR, Alu-type repetitive DNA, and papovavirus.
Sequences analogous to the intragenic bipartite RNA polymerase III promoter regions in tRNA genes, are described in mammalian Alu-type repetitive DNA, LTR of retroviruses and control regions of papovaviruses. The RNA polymerase III control regions in some of these DNA elements are present in enhancer sequences which are known to increase the transcription of RNA polymerase II transcribed genes. It is suggested that the host and tissue specificity of the enhancer elements may be explained by differences in the RNA polymerase III control sequences. The RNA polymerase III promoters may thus participate in regulation of cell differentiation and transcription of tissue specific genes.
D000818:Animals; D002454:Cell Differentiation; D004247:DNA; D004279:DNA, Viral; D012321:DNA-Directed RNA Polymerases / Q000235:genetics*; D006801:Humans; D009876:Operon; D027383:Papillomaviridae / Q000235:genetics*; D027382:Polyomaviridae; D012320:RNA Polymerase III / Q000235:genetics*; D012091:Repetitive Sequences, Nucleic Acid; D012190:Retroviridae / Q000235:genetics*; D014158:Transcription, Genetic
D004279:DNA, Viral; D004247:DNA; D012321:DNA-Directed RNA Polymerases; D012320:RNA Polymerase III