[Effect of ribavirin on the reproduction of influenza B virus].
The influence of ribavirin on influenza B virus reproduction was studied at different experimental levels. Ribavirin was found to reduce significantly the production of hemagglutinin and accumulation of infectious influenza B/Lee/40 virus in MDCK cell culture. Synthesis of virus-specific polypeptides of influenza B/Hong Kong/5/72 virus was markedly reduced in its presence. Ribavirin in a dose of 100 mg/kg inhibited the infectious titre of influenza B/Lee/40 virus considerably and prevented the development of inflammatory reactions in pulmonary tissue of white mice.
D000818:Animals; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006389:Hemagglutinins, Viral; D051379:Mice; D009975:Orthomyxoviridae / Q000187:drug effects* / Q000502:physiology; D010452:Peptide Biosynthesis; D012254:Ribavirin / Q000494:pharmacology*; D012263:Ribonucleosides / Q000494:pharmacology*; D014776:Virus Cultivation / Q000379:methods; D014779:Virus Replication / Q000187:drug effects*
D006389:Hemagglutinins, Viral; D012263:Ribonucleosides; D012254:Ribavirin
Vliianie ribavirna na reproduktsiiu virusa grippa B.