Butyl hydroxy toluene antagonizes the gastric toxicity but not the pharmacological activity of acetylsalicylic acid in rats.
Butyl hydroxy toluene reduced gastric erosion due to acetylsalicylic acid in the rat, but not the antiinflammatory, anti-pyretic and analgesic activity. By itself, BHT exhibited activity only in the test on analgesia.
D000698:Analgesia; D000818:Animals; D001241:Aspirin / Q000037:antagonists & inhibitors* / Q000627:therapeutic use / Q000633:toxicity; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D002351:Carrageenan; D004487:Edema / Q000188:drug therapy; D005334:Fever / Q000188:drug therapy; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013270:Stomach / Q000187:drug effects*
D002084:Butylated Hydroxytoluene; D002351:Carrageenan; D001241:Aspirin