Antithrombic properties of insoluble modified polystyrene: Part I.
Chlorosulfonated polystyrenes grafted with arginyl methyl ester have been synthetized and characterized by elemental analyses. When suspended in plasma or in fibrinogen solutions, these insoluble polymers cause an increase in the thrombin clotting time. Consequently the antithrombin activity observed is not dependent upon to the presence of antithrombin III. Binding between the resin and thrombin can be demonstrated. An approximative value of the affinity constant is calculated: 2.3 X 10(6) 1/M. At high ionic strength, thrombin can be desorbed and exhibits normal coagulation properties. The prolongation of the thrombin time therefore can be attributed to the thrombin-resin interaction.
D000042:Absorption; D000990:Antithrombin III / Q000378:metabolism; D001780:Blood Coagulation Tests; D006801:Humans; D009994:Osmolar Concentration; D011137:Polystyrenes / Q000627:therapeutic use*; D012117:Resins, Synthetic / Q000378:metabolism; D012995:Solubility; D013927:Thrombosis / Q000517:prevention & control*
D011137:Polystyrenes; D012117:Resins, Synthetic; D000990:Antithrombin III