The acute intravenous and oral toxicity in mice, rats and guinea-pigs of 4-dimethylaminophenol (DMAP) and its effects on haematological variables.
The single dose oral toxicity of 4- dimethylaminophenol (DMAP) was examined in mice, rats and guinea-pigs and the intravenous toxicity in mice. The oral LD50 in female mice was 946 mg kg-1, in male rats, 780 mg kg-1, in female rats 689 mg kg-1 and in female guinea-pigs 1032 mg kg-1. The intravenous LD50 in female mice was 70 mg kg-1. Dosing with DMAP at the maximum tolerated dose produced Heinz body haemolytic anaemia in rats and Heinz bodies unaccompanied by anaemia in mice. Rats showed biochemical and histological evidence of renal tubular changes.
D000284:Administration, Oral; D000627:Aminophenols / Q000633:toxicity* / Q000652:urine; D000743:Anemia, Hemolytic / Q000139:chemically induced; D000818:Animals; D001773:Blood Cells / Q000187:drug effects*; D005260:Female; D006168:Guinea Pigs; D006366:Heinz Bodies / Q000187:drug effects; D007275:Injections, Intravenous; D007674:Kidney Diseases / Q000139:chemically induced; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors; D013045:Species Specificity
D000627:Aminophenols; C020292:4-dimethylaminophenol