[Characteristics of the role of the hydroxyl group in serotonin in the pharmacological and antiradiation effect of serotonin].
It was shown that omega-hydroxylation of O-alkyl serotonin derivatives can slightly improve the radioprotective and pharmacological properties of these substances but fails to remove completely the unfavourable action of O-alkylation of serotonin. There is a close correlation between the radioprotective effect of 5-oxyalkoxytryptamines and their action on blood supply of mouse spleen. The introduction of the alkoxy-group or the tertiary amino-group into omega-position removes the radioprotective effect of 5-alkoxytryptamines.
D000818:Animals; D005260:Female; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use; D012039:Regional Blood Flow / Q000187:drug effects; D012701:Serotonin / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D013154:Spleen / Q000098:blood supply*
D011837:Radiation-Protective Agents; D012701:Serotonin
K kharakteristike roli gidroksil'noĭ gruppy serotonina v farmakologicheskom i protivoluchevom éffekte serotonina.