title: The relationship between non-invasive papillary lesions and invasive bladder carcinoma.
abstract: Ten patients with noninvasive papillary lesions who subsequently developed invasive bladder carcinoma were identified. Five of the 10 patients developed an invasive carcinoma in a location distinctly separate from any preceding papillary lesion. The remaining five patients developed an invasive carcinoma in the same general location as a preceding papillary lesion. These findings suggest that invasive bladder carcinomas, which develop in a patient with previous noninvasive papillary lesions, often arise from nonpapillary urothelium adjacent the noninvasive papillary lesion rather than directly from the preceding papillary lesion.
mesh_terms: D000368:Aged; D002291:Carcinoma, Papillary / Q000473:pathology*; D002295:Carcinoma, Transitional Cell / Q000473:pathology*; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D001743:Urinary Bladder / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000473:pathology*