[Labeling cerebral activity with 3H-deoxyglucose after milacemide administration in the rat].
Milacemide (2-n-pentylaminoacetamide . HCl) is an anti-epileptic which improves the mood, vigilance and sociability of treated patients. By metabolic charting with radioactive deoxyglucose it is possible to estimate local consumption of glucose in the various regions of the brain in rats treated with milacemide in comparison with rats treated with a placebo. It would seem that milacemide exerts an appreciable activating effect principally on pathways with sensory functions. The activation of the metabolism of cerebral energy in these regions may explain the behavioural improvements observed in the rat and in the first clinical trials in man.
D000081:Acetamides / Q000494:pharmacology*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001931:Brain Mapping; D002103:Cadaverine / Q000031:analogs & derivatives / Q000494:pharmacology*; D003847:Deoxyglucose / Q000378:metabolism; D003959:Diamines / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007858:Learning / Q000187:drug effects; D008297:Male; D008568:Memory / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013268:Stimulation, Chemical; D014316:Tritium
D000081:Acetamides; D000927:Anticonvulsants; D003959:Diamines; C039332:milacemide; D014316:Tritium; C025476:monoacetylcadaverine; D003847:Deoxyglucose; D005947:Glucose; D002103:Cadaverine
Marquage de l'activité cérébrale par le 3H-déoxyglucose après administration de la milacémide chez le rat.