The effect of alpha 2HS glycoprotein on lymphocyte reactivity to phytohemagglutinin.
The effect of alpha 2HS glycoprotein on lymphocyte reactivity to phytohemagglutinin (PHA) was investigated. The results show that alpha 2HS glycoprotein, rather than enhancing lymphocyte reactivity to PHA as suggested by earlier correlation studies, inhibits such reactivity. Experiments suggest that this inhibition is unlikely to be the result of alpha 2HS glycoprotein binding either PHA or 3H-thymidine but is more likely to act at the cellular level.
D001798:Blood Proteins / Q000494:pharmacology*; D003208:Concanavalin A / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects; D010835:Phytohemagglutinins / Q000037:antagonists & inhibitors; D012709:Serum Albumin / Q000494:pharmacology; D060749:alpha-2-HS-Glycoprotein
C556354:AHSG protein, human; D001798:Blood Proteins; D010835:Phytohemagglutinins; D012709:Serum Albumin; D060749:alpha-2-HS-Glycoprotein; D003208:Concanavalin A