Effects of DL-allylglycine, alone or in combination with morphine, on passive avoidance behaviour in C57BL/6 mice.
In a first set of experiments the posttrial intraperitoneal acute administration of the GAD-inhibitor DL-allylglycine impaired the memory processes of C57BL/6 (C57) mice tested in a passive avoidance apparatus. Memory improvements were, on the contrary, observed following morphine treatment. These effects were dose- and time-dependent. They were, in particular, evident if mice were injected immediately, or 30 min, but not 60 min, after training in the apparatus, and were absent in the no-footshock groups, suggesting lack of proactive effects of the drugs on performance. In a second set of experiments, the posttraining administration of allylglycine, at a per se ineffective dose (5 mg/kg), antagonized the memory improvement exerted by the administration of morphine (0.5 or 1.0 mg/kg). The results support the hypothesis of an involvement of GABAergic mechanisms in the memory consolidation processes, and suggest the possibility that GABAergic systems play a role in the effects of morphine on memory in C57BL/6 mice.
D000501:Allylglycine / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005998:Glycine / Q000031:analogs & derivatives*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009020:Morphine / Q000494:pharmacology*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D000501:Allylglycine; D005680:gamma-Aminobutyric Acid; D009020:Morphine; D005998:Glycine