Effect of aromatic carcinogens and noncarcinogenic analogs on the induction of murine alpha/beta interferon.
The effects of several aromatic carcinogens and their noncarcinogenic analogs on the production of alpha/beta interferon by mouse embryo fibroblasts were determined. The carcinogens 2-naphthylamine and 9,10-dimethylanthracene significantly depressed alpha/beta interferon production, while their poorly or noncarcinogenic analogs, 1-naphthylamine and anthracene, respectively, had no significant effect. Neither the carcinogen benzidine nor its poorly carcinogenic analog 3,3',5,5'-tetramethylbenzidine had any effect on alpha/beta interferon production. These data, taken together with previous findings, suggest the possibility of drawing a high correlation between the carcinogenic potential of a chemical and its effect on interferon production.
D000818:Animals; D002273:Carcinogens; D004622:Embryo, Mammalian / Q000187:drug effects*; D005347:Fibroblasts / Q000187:drug effects; D007370:Interferon Type I / Q000096:biosynthesis*; D051379:Mice; D008809:Mice, Inbred C3H; D011083:Polycyclic Compounds / Q000494:pharmacology*
D002273:Carcinogens; D007370:Interferon Type I; D011083:Polycyclic Compounds