Effects of chlorfenvinphos on plasma corticosterone and aldosterone levels in rats.
Plasma corticosteroids concentrations, in rats intoxicated with chlorfenvinphos (p.o. single dose 6.15 mg/kg), were investigated. A significant increase of corticosterone was observed at 1 and 3 h and aldosterone from 1 to 6 h after treatment. Brain and blood AChE activity was diminished to about 10-30% for up to 24 h, with maximal inhibition in brain at 2 h after treatment. Maximal increase in plasma corticosteroids levels occurred within 1 h, while the brain AChE was only slightly inhibited at that time. Results suggest that changes in plasma corticosteroids are not related to the decrease of AChE activity in brain.
D000110:Acetylcholinesterase / Q000378:metabolism; D000450:Aldosterone / Q000097:blood*; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002709:Chlorfenvinphos / Q000633:toxicity*; D003345:Corticosterone / Q000097:blood*; D007306:Insecticides / Q000633:toxicity*; D007928:Lethal Dose 50; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D007306:Insecticides; D000450:Aldosterone; D000110:Acetylcholinesterase; D002709:Chlorfenvinphos; D003345:Corticosterone