Prophylaxis of Candida albicans infection in neutropenic mice with liposome-encapsulated amphotericin B.
The efficacy of liposome-encapsulated amphotericin B in the prophylaxis of disseminated Candida albicans infections in neutropenic mice was studied. The administration of liposome-encapsulated amphotericin B was associated with protection against infection with C. albicans when used at doses of greater than or equal to 2 mg of amphotericin B per kg of body weight. Neither empty liposomes nor free amphotericin B showed prophylactic efficacy.
D000380:Agranulocytosis / Q000150:complications*; D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D002177:Candidiasis / Q000517:prevention & control*; D003520:Cyclophosphamide / Q000494:pharmacology; D007275:Injections, Intravenous; D008081:Liposomes; D051379:Mice; D009503:Neutropenia / Q000150:complications*
D008081:Liposomes; D000666:Amphotericin B; D003520:Cyclophosphamide