Hepatitis in a dog given sulfadiazine-trimethoprim and cyclophosphamide.
Vomiting, diarrhea, icterus and elevated serum alkaline phosphatase, SGPT and serum bilirubin levels occurred in a 12-year-old Basenji on sulfadiazine-trimethoprim and cyclophosphamide therapy. After use of the antibacterial drug was discontinued, the dog returned to normal with no further evidence of hepatocellular damage.
D000818:Animals; D000892:Anti-Infective Agents, Urinary / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000662:veterinary*; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004283:Dog Diseases / Q000139:chemically induced* / Q000188:drug therapy; D004285:Dogs; D004338:Drug Combinations / Q000009:adverse effects; D004359:Drug Therapy, Combination; D005260:Female; D008297:Male; D013411:Sulfadiazine / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects*; D000096926:Benzenesulfonamides
D000892:Anti-Infective Agents, Urinary; D003520:Cyclophosphamide; D004338:Drug Combinations; D013411:Sulfadiazine; D014295:Trimethoprim; C024873:sulfadiazine, trimethoprim drug combination; D000096926:Benzenesulfonamides