title: Blood and tissue distribution of cyclosporin A after a single oral dose in the rat.
abstract: After a single oral dose of cyclosporin A (82 mg/kg) in rats, tissue (kidneys liver and brain) and blood levels reached maximum values (approximately 80 micrograms/g and 3.5 micrograms/ml) between 3 and 7 h after drug administration. Drug elimination continued for at least 5 days. The 24-h urine and bile elimination was 2% for each.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001646:Bile / Q000378:metabolism; D003524:Cyclosporins / Q000008:administration & dosage / Q000378:metabolism*; D005260:Female; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D003524:Cyclosporins