Effects of mazindol on lipid metabolism of human adipose tissue in vitro.
The interaction of mazindol with catecholamine in regulating peripheral lipid metabolism was studied in vitro. Noradrenaline-induced and adrenaline-induced glycerol release was augmented by addition of 50 ng mazindol. On the other hand, isoproterenol-induced glycerol release was suppressed by addition of 50 ng mazindol. Basal and dopamine-induced glycerol release was not altered by addition of 50 ng mazindol. These results suggest that mazindol may interact with alpha 2-adrenergic receptors in adipose tissue.
D000273:Adipose Tissue / Q000187:drug effects*; D000328:Adult; D000368:Aged; D002395:Catecholamines / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005990:Glycerol / Q000378:metabolism; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D050356:Lipid Metabolism; D008053:Lipid Mobilization / Q000187:drug effects; D008297:Male; D008454:Mazindol / Q000494:pharmacology*; D008875:Middle Aged
D002395:Catecholamines; D007211:Indoles; D008454:Mazindol; D005990:Glycerol