Amiodarone-induced ultrastructural changes in human eyes.
Ocular observations in a series of 100 patients treated with amiodarone, along with the pathological changes observed in the eye tissues of two patients treated with this drug, are described in this paper. In the latter two patients intracytoplasmic membrane-bound lamellar bodies similar to myelin were observed by electron microscopy not only in the corneal epithelium and fibroblasts, the conjunctiva and the lens, but also in the corneal endothelium, the iris, the ciliary body, the choroid and the retina. It is suggested that patients taking amiodarone in high dosage for long periods have their eyes and retinal function monitored.
D000638:Amiodarone / Q000009:adverse effects*; D001572:Benzofurans / Q000009:adverse effects*; D003316:Corneal Diseases / Q000139:chemically induced / Q000473:pathology; D005123:Eye / Q000473:pathology / Q000648:ultrastructure*; D005128:Eye Diseases / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D012164:Retinal Diseases / Q000139:chemically induced / Q000473:pathology
D001572:Benzofurans; D000638:Amiodarone