Clastogenic effects of biosynthetic human growth hormone in Snell dwarf mice and CHO cells in vitro.
Treatment of Snell dwarf mice with high concentrations of human growth hormone from pituitaries as well as of bacterial origin, significantly increased the frequencies of chromosomal aberrations in bone-marrow cells, as measured by the micronucleus test. In vitro treatment of Chinese hamster ovary (CHO) cells with the two types of hormone likewise induced structural chromosomal aberrations.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D002467:Cell Nucleus / Q000187:drug effects; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006224:Cricetinae; D013006:Growth Hormone / Q000096:biosynthesis / Q000494:pharmacology*; D051379:Mice; D008817:Mice, Mutant Strains / Q000502:physiology; D009154:Mutation / Q000187:drug effects*
D013006:Growth Hormone