title: Weight reduction in boys with muscular dystrophy.
abstract: Many children with muscular dystrophy are overweight, and although weight control is pursued in some centres it is unusual to encourage severe dietary restriction for fear that it might lead to accelerated loss of muscle. In this study, two overweight boys with muscular dystrophy were monitored by whole-body nitrogen balance, total body potassium, strength and functional measurements during calorie restriction. Both patients were found to have a transient loss of nitrogen on commencing the low calorie intake: thereafter, weight loss was not found to have any deleterious effect on muscle bulk or function in either patient. It is suggested that controlled weight-reduction in obese children with muscular dystrophy is a safe and practical way of losing excess fat, which can improve mobility and self-esteem, and may possibly effect longevity.
mesh_terms: D000293:Adolescent; D001823:Body Composition; D002648:Child; D003402:Creatine Kinase / Q000097:blood; D003404:Creatinine / Q000097:blood; D004038:Diet, Reducing; D002149:Energy Intake; D006801:Humans; D008297:Male; D009119:Muscle Contraction; D009124:Muscle Proteins / Q000378:metabolism; D009136:Muscular Dystrophies / Q000150:complications*; D009751:Nutritional Requirements; D009765:Obesity / Q000178:diet therapy*; D014882:Water-Electrolyte Balance
chemical_list: D009124:Muscle Proteins; D003404:Creatinine; D003402:Creatine Kinase