Pharmacokinetics of ticarcillin in the horse after intravenous and intramuscular administration.
Serum and peritoneal fluid concentrations of ticarcillin were measured in 10 healthy adult horses from 0.5 to 8 hours after IV or IM administration of 44 mg/kg of body weight. After IV injection, the serum concentration at 30 minutes was 104.3 +/- 6.1 mg/L and the mean peak peritoneal fluid concentration (61.4 +/- 29.0 mg/L) occurred 2 hours after injection. The peak serum (28.3 +/- 5.5 mg/L) and the peak peritoneal fluid concentrations (19.2 +/- 6.0 mg/L) occurred 2 hours after the IM injection. Ticarcillin (greater than or equal to 2 mg/L) persisted in serum and peritoneal fluid for 6 hours after IV injection and 8 hours after IM injection. The half-life of ticarcillin was 0.94 hour after IV injection and the bioavailability of ticarcillin administered IM was 64.9%.
D000042:Absorption; D000818:Animals; D001202:Ascitic Fluid / Q000378:metabolism; D001682:Biological Availability; D005260:Female; D006207:Half-Life; D006736:Horses / Q000378:metabolism*; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D010406:Penicillins / Q000378:metabolism*; D013982:Ticarcillin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
D010406:Penicillins; D013982:Ticarcillin