Fluosol-DA, a perfluorochemical oxygen-transport fluid for the management of a trochanteric pressure sore in a Jehovah's Witness.
A 54-year-old paraplegic with a right trochanteric pressure sore was refused reconstructive surgery because of his hemoglobin count of 6 gm/dl and his refusal to accept blood transfusions because of religious beliefs. Utilization of Fluosol-DA, a perfluorochemical oxygen-transport fluid that has recently become available to us for clinical trial, enabled us to deal successfully with this man's problem despite the profound anemia, since tissue oxygen delivery was provided with arterial oxygen partial pressures as high as 500 torr after infusion. Patients previously denied operations on the basis of their blood counts and their refusal to receive blood transfusions may in the future be offered the option of an oxygen-carrying fluid such as Fluosol to allow them to safely undergo reconstructive procedures.
D002835:Christianity; D004338:Drug Combinations / Q000494:pharmacology / Q000627:therapeutic use; D005269:Femur; D005466:Fluorocarbons / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D003668:Pressure Ulcer / Q000601:surgery*
D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination; D010100:Oxygen