Cortical spike wave discharges during audiogenic convulsions in rats.
Audiogenic seizure-susceptible rats show high-amplitude spikes and waves in the electrocorticogram during the tonic phase of a maximal audiogenic convulsion. This observation establishes the validity of this seizure type as an animal model for human generalized epilepsy.
D000161:Acoustic Stimulation; D000818:Animals; D002540:Cerebral Cortex / Q000503:physiopathology*; D004553:Electric Conductivity; D004569:Electroencephalography; D005260:Female; D008297:Male; D051381:Rats; D012640:Seizures / Q000503:physiopathology*