(3H)-spiroperidol binding sites in the rabbit splenic artery.
The topographic distribution of (3H)-spiroperidol binding sites (corresponding to dopamine receptors likely) was studied in rabbit splenic artery by the use of a histoautoradiographic technique. (3H)-spiroperidol was localized preferentially at the level of smooth muscle cells of the media as well as in close relation with cellular membrane of endothelial cells. The findings of a constant distribution of (3H)-spiroperidol binding sites within the medial layer of the splenic artery led us to hypothesize that these receptors mediate the relaxation of the splenic artery determined by dopamine infusion.
D000818:Animals; D001665:Binding Sites; D002090:Butyrophenones / Q000494:pharmacology*; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000378:metabolism; D011817:Rabbits; D011954:Receptors, Dopamine / Q000378:metabolism*; D013134:Spiperone / Q000494:pharmacology*; D013157:Splenic Artery / Q000187:drug effects / Q000378:metabolism*
D002090:Butyrophenones; D011954:Receptors, Dopamine; D013134:Spiperone; D006220:Haloperidol