Effects of dietary linoleic acid on rat platelet ADP-induced aggregation and binding of 125I-fibrinogen.
Platelets from rats fed a diet high in linoleic acid (6%) bound increased amounts of fibrinogen on stimulation with ADP, compared to those from rats fed diets with low (2%) or no linoleic acid. However, this increased fibrinogen binding was associated with a decrease in platelet aggregation induced by ADP. Changes in the linoleic acid concentration in platelet membranes may cause changes in this relationship.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001792:Blood Platelets / Q000378:metabolism; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005340:Fibrinogen / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008041:Linoleic Acids / Q000494:pharmacology*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D007457:Iodine Radioisotopes; D008041:Linoleic Acids; D000244:Adenosine Diphosphate; D005340:Fibrinogen