Hemodialysis without anticoagulants: efficiency and hemostatic aspects.
In 29 patients with high risk of bleeding, 111 hemodialyses have been performed without heparin (WHD) or other anticoagulants. The same patients were switched to low dose heparin dialysis (LDHD) as soon as the bleeding risk had ceased. The dialyzer had to be changed in 11 and the drip chamber in 20 WHDs because of partial clotting. This phenomenon did not occur during LDHD. The comparative efficiencies of the two techniques were evaluated by measuring the urea and creatinine clearances of the dialyzers. No significant difference between LDHD and WHD clearances was observed. In 7 of 29 patients, hemostasis variables were studied before, during and after both modes of treatment. Fibrinogen, platelet count, antithrombin III and prothrombin time did not differ with the different dialysis procedures. During dialysis, platelet factor 4 (PF4) levels were significantly higher than baseline values (P less than 0.01), with no difference between WHD and LDHD. Plasma fibrinopeptide A (FPA) levels remained normal during LDHD, but significantly increased during WHD (P less than 0.001). Our data indicate that WHD is feasible, with a low risk of extravascular coagulation. The bleeding risk is not increased during or after dialysis, and the danger of intravascular coagulation is low as confirmed by the isolated elevation of FPA plasma levels, unaccompanied by changes in other variables.
D058186:Acute Kidney Injury / Q000097:blood* / Q000150:complications / Q000628:therapy; D000328:Adult; D003404:Creatinine / Q000378:metabolism; D005340:Fibrinogen / Q000032:analysis; D006470:Hemorrhage / Q000139:chemically induced / Q000517:prevention & control*; D006487:Hemostasis; D006493:Heparin / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D008875:Middle Aged; D010976:Platelet Count; D011517:Prothrombin Time; D006435:Renal Dialysis / Q000379:methods*; D012306:Risk; D014508:Urea / Q000378:metabolism
D014508:Urea; D005340:Fibrinogen; D006493:Heparin; D003404:Creatinine