title: N-Trifluoroacetyl derivatives as pharmacological agents. II. Trifluoroacetanilides: synthesis and antiinflammatory activity.
abstract: The analogy with the anti-inflammatory trifluoromethane-sulfonanilides prompted us to the synthesis of a series of trifluoroacetanilides which were found to maintain the pharmacological properties of the analog sulfonanilides. Many of the obtained compounds inhibited either the carrageenin-induced rat paw edema and the adjuvant-induced arthritis; some showed better anti-inflammatory properties than indomethacin and phenylbutazone. Acute toxicity and ulcerogenic effects were significantly lower than those of reference drugs.
mesh_terms: D000083:Acetanilides / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D001169:Arthritis, Experimental / Q000188:drug therapy; D004487:Edema / Q000188:drug therapy; D005260:Female; D006633:Histamine Antagonists / Q000138:chemical synthesis; D008297:Male; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013276:Stomach Ulcer / Q000139:chemically induced
chemical_list: D000083:Acetanilides; D000893:Anti-Inflammatory Agents; D006633:Histamine Antagonists