In vitro binding of amantadine to plasma proteins.
In vitro binding of amantadine to plasma protein was assessed by ultrafiltration of plasma samples (from a blood bank) to which amantadine hydrochloride had been added. Approximately two-thirds of the amantadine was found to be protein-bound. The degree of protein binding was constant over a plasma amantadine concentration range of 100-2,000 ng/ml.
D000547:Amantadine / Q000378:metabolism*; D001798:Blood Proteins / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D011485:Protein Binding; D012709:Serum Albumin / Q000378:metabolism; D014462:Ultrafiltration
D001798:Blood Proteins; D012709:Serum Albumin; D000547:Amantadine