Putrescine has analgesic activity, in rats.
Putrescine, intraperitoneally injected into rats at doses of 200, 300 and 400 mg/Kg, had a dose-dependent analgesic effect (hot plate, 55.5 degrees C), which was not antagonized by naloxone. Analgesia was also obtained by intracerebroventricular injection (1,000 nmoles/rat). Chronic administration (300 mg/Kg/day i.p. for 8 consecutive days) resulted in the development of tolerance. In our experimental conditions, no obvious toxicity was observed. These results may suggest for polyamines a role in nociception, and may disclose a new class of analgesic drugs.
D000700:Analgesics; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D005260:Female; D007274:Injections, Intraperitoneal; D007276:Injections, Intraventricular; D009270:Naloxone / Q000494:pharmacology; D011700:Putrescine / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D011930:Reaction Time / Q000187:drug effects; D012684:Sensory Thresholds / Q000187:drug effects
D000700:Analgesics; D009270:Naloxone; D011700:Putrescine