title: Distribution of phenobarbital in serum, brain and other organs from pediatric patients.
abstract: The present study was performed to determine whether serum levels of phenobarbital were representative of their concentrations in the brains obtained from 11 autopsied patients, including premature and full-term babies, infants and children. Estimation of phenobarbital concentrations in plasma and organs was performed by high-pressure liquid chromatography. Brain phenobarbital concentrations correlated well with serum levels (r = 0.82, p less than 0.01, n = 11), giving a regression line with a slope of 0.75. It can be concluded that estimating the serum phenobarbital concentration during clinical pediatric practice gives a good indication of the brain concentration.
mesh_terms: D001826:Body Fluids / Q000032:analysis; D001921:Brain / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010634:Phenobarbital / Q000097:blood / Q000378:metabolism* / Q000627:therapeutic use; D012640:Seizures / Q000188:drug therapy; D014018:Tissue Distribution
chemical_list: D010634:Phenobarbital