title: Effects of body temperature, passive limb motion and level of anesthesia on the activity of the inspiratory muscles.
abstract: The relationships between relative tidal activity (moving average EMG) of the diaphragm (AdiT) and of the external intercostal or parasternal muscles (AicT) and between the rate of rise of these activities (Adi and Aic) were assessed during rebreathing in rabbits with various body temperatures (BT: 34-41 degrees C) before and after vagotomy (VGT), at rest and during passive limb motion (PLM), and in vagotomized rabbits with or without thoracic dorsal rhizotomy (TDR) under light (LBA) or deep barbiturate anesthesia (DBA). Both relationships had the form AicT = a AdiTb and Aic = a' Adib'. In intact normothermic animals under LBA mean values for b and b' were 1.47 and 1.37, a and a' being unity by definition. No changes in b or b' occurred even with TDR: this suggests that the relation between the central command to phrenic and to inspiratory intercostal alpha-motoneurones was the same under all conditions. Neither BT nor PLM modified a', but a changed owing to BT and PLM dependence of the relation between central inspiratory drive and off-switch threshold. Both VGT, independently of BT, and DBA decreased a and a' before but not after TDR, when a and a' reached the lowest values (0.12 and 0.22). Hence VGT and DBA, but not BT and PLM, change the relation between the central command to inspiratory intercostal alpha- and gamma-motoneurones, the multiplicative effect of alpha-gamma linkage on AicT and Aic being prevented by TDR.
mesh_terms: D000768:Anesthesia, General; D000818:Animals; D001463:Barbiturates / Q000494:pharmacology*; D001831:Body Temperature; D006614:Hindlimb; D009068:Movement; D009132:Muscles / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits; D012143:Respiratory Physiological Phenomena; D014628:Vagotomy
chemical_list: D001463:Barbiturates