title: Effect of premedication on the induction dose of thiopentone in children.
abstract: The effective dose of thiopentone in 90% ( ED90 ) of unpremedicated children is 10.5 mg/kg. This is significantly greater (p less than 0.01) than in premedicated children. The ED90 in children premedicated with TDP (a mixture of trimeprazine , droperidol and physeptone with atropine) is 4.2 mg/kg which is significantly less (p less than 0.05) than with trimeprazine and atropine ( ED90 5.2 mg/kg) or papaveretum and hyoscine ( ED90 5.0 mg/kg).
mesh_terms: D000771:Anesthesia, Intravenous; D001285:Atropine; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004329:Droperidol; D004338:Drug Combinations; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008691:Methadone; D009892:Opium; D011229:Preanesthetic Medication; D012601:Scopolamine; D013874:Thiopental / Q000008:administration & dosage*; D014291:Trimeprazine
chemical_list: D004338:Drug Combinations; D014291:Trimeprazine; D001285:Atropine; D009892:Opium; D012601:Scopolamine; D013874:Thiopental; D004329:Droperidol; D008691:Methadone