The effects of intraprosthetic methylprednisolone on implant capsules and surrounding soft tissue.
One of the many methods that have been suggested for the prevention of implant capsule contracture is the use of soluble steroids within the implant. In this study a range of concentrations of methylprednisolone hemisuccinate was tested in rabbits, and even the lowest concentration was found to be effective in the prevention of contracture. Higher concentrations were found to result in extremely large capsules. No atrophy of the skin over the implants was seen even with use of the highest concentrations of the steroid, but this may have been due to the short (five-month) interval between implant placement and measurement.
D000818:Animals; D002921:Cicatrix / Q000517:prevention & control*; D062109:Dermatologic Surgical Procedures; D004305:Dose-Response Relationship, Drug; D005260:Female; D008775:Methylprednisolone / Q000008:administration & dosage / Q000494:pharmacology*; D009132:Muscles / Q000033:anatomy & histology / Q000187:drug effects; D019736:Prostheses and Implants; D011817:Rabbits; D012867:Skin / Q000033:anatomy & histology / Q000187:drug effects*; D014945:Wound Healing
D008775:Methylprednisolone