title: [Sinus histiocytosis with massive lymphadenopathy--a virus-associated disease?].
abstract: Clinical course and laboratory data of three patients with sinus histiocytosis and massive lymphadenopathy ( SHML ) are described. In 80% of the cases a massive and painless bilateral enlargement of the cervical lymphnodes is the presenting feature; 25% show extranodal involvement. The etiology of SHML is as yet unknown. In two patients with a high rubella antibody titer we were able to demonstrate rubella antigen in the involved lymphnodes thus supporting an infectious etiology of SHML . A virus isolation was not possible, so that the definite proof of a viral infection of SHML could not be demonstrated. As a rule therapy is not necessary. The exceptions are outlined. The prognosis is good.
mesh_terms: D000293:Adolescent; D000956:Antigens, Viral / Q000032:analysis; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006644:Histiocytes / Q000648:ultrastructure*; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008206:Lymphatic Diseases / Q000276:immunology / Q000473:pathology*; D008297:Male; D012409:Rubella / Q000276:immunology; D014777:Virus Diseases / Q000276:immunology / Q000473:pathology*
chemical_list: D000956:Antigens, Viral
vernacular_title: Sinushistiozytose mit massiver Lymphadenopathie--eine virusassoziierte Erkrankung?