title: Cell sensitivity to gravity.
abstract: Cultures of human lymphocytes exposed in microgravity to the mitogen concanavalin A showed less than 3 percent of the activation of ground controls. This result supports the hypothesis, based on simulations at low g and experiments at high g, that microgravity depresses whereas high gravity enhances cell proliferation rates. The effects of gravity are particularly strong in cells undergoing differentiation.
mesh_terms: D002454:Cell Differentiation; D002468:Cell Physiological Phenomena; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000502:physiology; D013026:Space Flight; D014893:Weightlessness
chemical_list: D003208:Concanavalin A