Serotonergic receptor antagonist from Nandina domestica Thunberg.
A crude methanolic extract of the fruit of Nandina domestica Thunberg strongly inhibits serotonin-induced contractions of the rabbit aorta. The extract of the fruit has been fractionated to afford nantenine (O- methyldomesticine ) as the active agent.
D000818:Animals; D001060:Aporphines / Q000302:isolation & purification* / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000302:isolation & purification*
D001060:Aporphines; D010936:Plant Extracts; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D011189:Potassium Chloride; D006632:Histamine; C041615:nantenine