[Bone levels of dibekacin].
Levels of an aminoglycoside, dibekacin, are studied in bone. Fifteen specimens were obtained by Tanzer trocar biopsy three hours after the ninth injection of dibekacin (1 mg/kg). Separation of cortical and spongy bone was not feasible owing to the small weight of specimens. Dibekacin concentrations were determined by microbiological assay. These concentrations were evaluated using a reference range in bone tissue determined with the same method and must be corrected according to blood levels. Dibekacin levels were 0.22 +/- 0.10 mg/l in healthy, non- contaminated specimens, and 1.70 and 1.80 mg/l in infected bone tissue.
D001424:Bacterial Infections / Q000188:drug therapy; D001847:Bone Diseases / Q000188:drug therapy; D001842:Bone and Bones / Q000378:metabolism*; D003982:Dibekacin / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007612:Kanamycin / Q000031:analogs & derivatives*; D007700:Kinetics
D003982:Dibekacin; D007612:Kanamycin
Concentration osseuse de la dibékacine.