title: Synthesis of [N-methyl-3H]-7-chloro-1,3-dihydro-5-(2-fluorophenyl)-1-methyl-2 H-1,4-benzodiazepin-2- one (3H-fludiazepam) by phase transfer catalysis.
abstract: [N-methyl-3H]-7-Chloro-1,3-dihydro-5-(2-fluorophenyl)-1-methyl-2H-1,4- benzodiazepin-2- one ( [3H]fludiazepam) was prepared by phase transfer catalytic N-methylation of the corresponding nor-derivative with [3H]methyl iodide [407 GBq/mmol (11 Ci/mmol)] in a radiochemical yield of 34%. The specific activity was 271.6 GBq/mmol (7.34 Ci/mmol).
mesh_terms: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D002384:Catalysis; D003975:Diazepam / Q000031:analogs & derivatives*; D006847:Hydrocarbons, Iodinated; D007553:Isotope Labeling / Q000379:methods*; D008745:Methylation; D014316:Tritium
chemical_list: D014151:Anti-Anxiety Agents; D006847:Hydrocarbons, Iodinated; D014316:Tritium; D001569:Benzodiazepines; C006107:fludiazepam; C014055:methyl iodide; D003975:Diazepam