The effect of 5 alpha-dihydrotestosterone and 5 beta-dihydrotestosterone on erythropoiesis of the newt, Triturus cristatus carnifex (Laur.).
The erythropoietic effects of 5 alpha-dihydrotestosterone (5 alpha-DHT) and 5 beta-dihydrotestosterone (5 beta-DHT) were compared in the newt, Triturus cristatus carnifex (Laur.). In normal animals, 5 beta-DHT was more active than 5 alpha-DHT in increasing the number of circulating erythrocytes. In animals rendered completely anemic, only 5 beta-DHT was effective. The biochemical parameters of delta-aminolevulinic acid synthase and delta-aminolevulinic acid dehydratase of new basophilic erythroblasts, and incorporation of labeled glycine into heme and globin of new polychromatic erythroblasts were enhanced by 5 beta-DHT. The results are discussed with reference to a direct erythropoietin-independent action of 5 beta-DHT on erythroid stem cells.
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism; D000818:Animals; D001491:Basophils / Q000378:metabolism; D013196:Dihydrotestosterone / Q000494:pharmacology*; D004900:Erythroblasts / Q000166:cytology; D004906:Erythrocyte Count; D004920:Erythropoiesis / Q000187:drug effects*; D005914:Globins / Q000378:metabolism; D005998:Glycine / Q000378:metabolism; D006418:Heme / Q000378:metabolism; D008297:Male; D000623:Porphobilinogen Synthase / Q000378:metabolism; D012455:Salamandridae / Q000502:physiology*
D013196:Dihydrotestosterone; D006418:Heme; D005914:Globins; D000624:5-Aminolevulinate Synthetase; D000623:Porphobilinogen Synthase; D005998:Glycine