Prenatal identification of a deleted Y chromosome by cytogenetics and a Y-specific repetitive DNA probe.
A very small sex chromosome was identified prenatally as a Y chromosome by using molecular hybridization in conjunction with conventional cytogenetics techniques. The combination of R-banding, Q-banding, distamycin-DAPI staining suggested that the chromosome might be a de novo deletion of the Y chromosome as the father's Y chromosome was normal. Restriction enzyme analysis of amniotic fluid cell DNA using a Y chromosome repetitive probe confirmed the origin of this chromosome.
D000328:Adult; D000653:Amniotic Fluid / Q000032:analysis; D002871:Chromosome Banding; D002872:Chromosome Deletion; D004247:DNA / Q000032:analysis*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D011247:Pregnancy; D011296:Prenatal Diagnosis; D012729:Sex Chromosome Aberrations / Q000175:diagnosis*; D014998:Y Chromosome
D004247:DNA