Effect of vitamin E on IgE antibody formation in mice.
Effect of vitamin E (alpha-tocopheryl acetate and alpha-tocopheryl nicotinate) on IgE antibody formation in mice was investgiated . Female BALB/c mice were immunized with dinitrophenylated ascaris protein (DNP-As) and aluminium hydroxide gel (alum). Supplementation of vitamin E in diets or oral administration of vitamin E mixed with sesame oil resulted in a suppression of IgE antibody formation. On the contrary to IgE antibody formation, IgM or IgG (hemagglutinin; HA) formation was significantly enhanced. These results indicate that vitamin E is capable of suppressing IgE antibody formation and enhancing non-IgE antibody formation.
D000284:Administration, Oral; D000818:Animals; D001200:Ascaris / Q000276:immunology; D004032:Diet; D005260:Female; D006386:Hemagglutination Tests; D007073:Immunoglobulin E / Q000096:biosynthesis*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009539:Nicotinic Acids / Q000378:metabolism; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D009539:Nicotinic Acids; D014810:Vitamin E; D007073:Immunoglobulin E; C012581:alpha-tocopheryl nicotinate; D024502:alpha-Tocopherol; D024505:Tocopherols