Organic acid transport to the blood from the corpus striatum, the thalamus and the cerebellum of the rat.
Conscious rats were given intracerebral injections by preplaced microsyringes. The injectates were 0.3-0.5 microliters of 125I- and 131I-o-iodohippurate. One hour after injection the isotopes present in the unopened cranial cavity were measured by gamma spectrometry. Some animals received 200 mg/kg probenecid intraperitoneally and this reduced the rate of absorption from injectates into the corpus striatum to 65.7 +/- 12.6% of control; from injectates into the cerebellum to 57.1 +/- 9.8% of control. Dye injections showed that injections into the cerebellum did not remain in the parenchyma, in contrast to injections into the corpus striatum or thalamus. Probenecid was also given as 2.9% solution, pH 7, mixed with the iodohippurate in the microsyringe. It had no effect on injections into the cerebellum, reduced the rate of absorption from the corpus striatum to 80.9 +/- 3.2% of controls and that from the thalamus to 88.3 +/- 2.2%. The results indicate parenchymal probenecid-sensitive transport of iodohippurate from the corpus striatum and thalamus but failed to settle the matter for the cerebellum.
D000042:Absorption; D000818:Animals; D001692:Biological Transport; D002531:Cerebellum / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism*; D007465:Iodohippuric Acid / Q000378:metabolism*; D008297:Male; D011339:Probenecid / Q000008:administration & dosage / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013788:Thalamus / Q000378:metabolism*
D007465:Iodohippuric Acid; D011339:Probenecid