Estimation of lobar minute volume in the rat.
In inhalation toxicology, the knowledge of minute volume is essential for the determination of the inhaled dose. We were unable to find in the literature any information on the minute volume of the various lobes of the rat. Utilizing available information on the deposition of 0.5 micron unit density spheres, we were able to show that lobar minute volume can be estimated from lobar burden. Equations are suggested for estimation of lobar minute volume from animal body weight.
D000336:Aerosols; D000818:Animals; D001822:Body Burden; D001835:Body Weight; D008168:Lung / Q000033:anatomy & histology / Q000502:physiology*; D008176:Lung Volume Measurements; D008863:Microspheres; D009929:Organ Size; D051381:Rats / Q000033:anatomy & histology / Q000502:physiology*
D000336:Aerosols