[Ultrastructure of terminal myocardial arteries in chronic ischemic heart disease].
The ultrastructure of the terminal arteries and arterioles was studied on biopsy samples obtained during aortocoronary bypass surgery in ten patients with stenosing atherosclerosis of the major coronary arteries and a history of chronic CHD. A complex of morphofunctional shifts was identified affecting all layers of the vessel wall and leading to readjustment of every coat. The major cellular populations directly involved included endotheliocytes, smooth muscle cells and stromal cells. Fibroblastic elements, penetrating by their processes up to the subendothelial zone stimulated total fibrosis of the vessel wall. The changes detected are indicative of the impaired patency and alterations in the responsiveness of resistant vessels which can considerably affect the microcirculation and trophicity of tissue.
D000328:Adult; D001158:Arteries / Q000648:ultrastructure; D001160:Arterioles / Q000648:ultrastructure; D003327:Coronary Disease / Q000378:metabolism / Q000473:pathology*; D003331:Coronary Vessels / Q000378:metabolism / Q000648:ultrastructure*; D004727:Endothelium / Q000648:ultrastructure; D006025:Glycosaminoglycans / Q000378:metabolism; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000648:ultrastructure; D009940:Organoids / Q000648:ultrastructure
D006025:Glycosaminoglycans
Ul'trastruktura terminal'nykh arteriĭ miokarda pri khronicheskoĭ ishemicheskoĭ bolezni serdtsa.