[Potentiation of the antimicrobial action of antibiotics in combination with oxytocin].
The antimicrobial effect of oxytocin in combination with 39 antibacterial drugs was studied in vitro with the use of 30 strains of different test cultures. It was shown that oxytocin had a capacity for potentiating the antibiotic effect on many microbial species. The potentiation ratio depended on the antibiotic and microbial species used and ranged from 2 to 24 times. The combined therapy with oxytocin and antibiotics was tested on animals with experimental staphylococcal sepsis. The survival rate of more than 50 per cent was observed only in the group of animals treated with the combinations of antibiotics and oxytocin, while in the other groups the death rate amounted to 100 per cent. The most favourable combinations of oxytocin and antibiotics were used in the treatment of 260 patients with pyoinflammatory affections of the soft tissues (mastitis, postinfection suppuration, paraproctitis, etc). In the majority of cases, the surgical treatment was replaced by the paracentetic treatment with local application of the combinations of oxytocin and antibiotics. This markedly decreased (by 3-4 times) the periods of temporary disability, provided better cosmetic results of the treatment and lowered consumption of the dressing material.
D000038:Abscess / Q000188:drug therapy; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001419:Bacteria / Q000187:drug effects*; D001424:Bacterial Infections / Q000188:drug therapy*; D002481:Cellulitis / Q000188:drug therapy; D004357:Drug Synergism; D005260:Female; D006801:Humans; D051379:Mice; D010121:Oxytocin / Q000008:administration & dosage*; D013045:Species Specificity; D013203:Staphylococcal Infections / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D010121:Oxytocin
Usilenie antimikrobnogo deĭstviia antibiotikov v kombinatsii s oksitotsinom.