title: [Mutagenic activity of the fungicide captan].
abstract: A complex study of mutagenic activity of captan (a fungicide) in a series of standard test-systems has shown that the preparation induces gene mutations in certain Salmonella indicator strains (without metabolic activation), increases the frequency of mitotic crossing-over and gene conversion in yeasts (Saccharomyces), possesses a weak cytogenetic action on bone marrow cells in experimental animals, manifests no cytogenetic effect in the lymphocyte culture of human peripheral blood (including a system of microsomal activation). Genetic activity of captan cannot be a limiting criterion of its harmfulness.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002215:Captan / Q000494:pharmacology*; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D051381:Rats; D012475:Salmonella / Q000187:drug effects; D015003:Yeasts / Q000187:drug effects
chemical_list: D009153:Mutagens; D002215:Captan
vernacular_title: K voporsu o mutagennoĭ aktivnosti fungitsida kaptana.