[Clinical studies using a photometric method for determining serum lipase activity].
Results of measurement of serum lipase activity as determined by a UV-test described by Myrick and a titrimetric assay as described by Rick were compared as far as sensitivity and specificity in diagnosis of pancreatitis is concerned. Sensitivity of the UV assay is low (45% falsely normal values), and specificity as well (falsely pathological values in 55.5% of patients with liver disease and 9% of normal persons). In the UV assay lipoproteinlipases are measured as well as hepatic esterases: in 17 samples from persons having received heparin lipase activity was increased 3-8 fold. In a total of 99 samples no correlation was found between the results of the 2 assays. As a consequence it can be stated that the UV-test as described by Myrick has no relevance in diagnosis of pancreatitis; the commercially available assay kit is withdrawn in the meantime.
D006801:Humans; D008049:Lipase / Q000097:blood*; D008107:Liver Diseases / Q000201:enzymology; D010182:Pancreatic Diseases / Q000201:enzymology; D010783:Photometry
D008049:Lipase
Klinische Untersuchungen mit einem photometrischen Verfahren zur Bestimmung der Serum-Lipaseaktivität.