Gangliosides and related compounds as biological response modifiers.
Several possibilities are discussed with regard to the biological potency of gangliosides and related compounds as biological response modifier. Evidence is presented that a ganglioside, GQ1b, but not other gangliosides examined exhibits a strong biological activity at a few nanomolar concentration for the promotion of neurite outgrowth as well as cell division in two cell lines of neuroblastoma.
D000818:Animals; D000906:Antibodies; D000954:Antigens, Surface / Q000276:immunology; D002460:Cell Line; D002462:Cell Membrane / Q000737:chemistry; D005732:Gangliosides / Q000276:immunology / Q000502:physiology*; D006028:Glycosphingolipids / Q000276:immunology; D007694:Killer Cells, Natural / Q000737:chemistry; D009414:Nerve Growth Factors; D009447:Neuroblastoma / Q000503:physiopathology
D000906:Antibodies; D000954:Antigens, Surface; D005732:Gangliosides; D006028:Glycosphingolipids; D009414:Nerve Growth Factors