Penicillin concentrations in blood and spinal fluid after a single intramuscular injection of penicillin G benzathine.
The concentration of penicillin in cerebrospinal fluid and blood was measured after a single i.m. injection of 1.44 g penicillin G benzathine in 18 individuals (4 with neurosyphilis and 14 with neurological symptoms but not syphilis). Only one person had a treponemicidal concentration in the cerebrospinal fluid.
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D009494:Neurosyphilis / Q000188:drug therapy; D010401:Penicillin G Benzathine / Q000008:administration & dosage / Q000378:metabolism*; D010406:Penicillins / Q000097:blood / Q000134:cerebrospinal fluid; D014208:Treponema / Q000187:drug effects
D010406:Penicillins; D010401:Penicillin G Benzathine