Factors affecting the lethality of Campylobacter fetus subspecies jejuni in mice.
Intraperitoneal injection of Campylobacter fetus ss. jejuni into HAM/1CR mice was lethal, but viable counts of bacteria from whole body homogenates, organs and blood indicated that death was not due to sustained bacterial multiplication. Heat-killed organisms (5 X 10(9) cfu) injected into 7-day-old mice caused death within 24 h and this was shown to be due to endotoxin. Both ferric iron and heterologous lipopolysaccharide enhanced virulence; the LD50 was lowered from 1.8 X 10(9) cfu to 2.7 X 10(7) cfu when both were used. Three-day-old or adult animals survived challenge with Campylobacter fetus without clinical symptoms when challenged orally or by intravenous or intraperitoneal routes.
D000375:Aging; D000818:Animals; D002169:Campylobacter Infections / Q000209:etiology / Q000276:immunology; D002168:Campylobacter fetus / Q000472:pathogenicity*; D004195:Disease Models, Animal; D004198:Disease Susceptibility; D005290:Ferric Compounds / Q000633:toxicity; D006358:Hot Temperature; D007501:Iron / Q000502:physiology; D007928:Lethal Dose 50; D008070:Lipopolysaccharides / Q000633:toxicity; D051379:Mice; D008815:Mice, Inbred Strains; D000644:Quaternary Ammonium Compounds / Q000633:toxicity
D005290:Ferric Compounds; D008070:Lipopolysaccharides; D000644:Quaternary Ammonium Compounds; D007501:Iron; C013531:ferric ammonium citrate