CNS, anthelmintic and antiinflammatory activities of some 1-[2/3-(2-phenyl benzimidazole)]2-methyl/phenyl-4-(3,4-disubstituted benzylidene)5-oxo-imidazoles.
Twelve title compounds were synthesised by condensing 2-(2/3 amino phenyl)benzimidazoles with appropriate 2-methyl/phenyl 4(3,4-disubstituted benzylidene)oxazolin 5-ones in dry pyridine and screened for toxicity gross CNS, anthelmintic and anti-inflammatory activities. In their lethal test, all the compounds were found to be non-toxic, and CNS depressants and hypothermic in their neuropharmacological testings. They showed valuable results against N. brasiliensis, whereas, were inactive against H. nana in their in vivo anthelmintic screening. Most of them showed remarkable anti-inflammatory activity against carrageenin induced oedema.
D000818:Animals; D000871:Anthelmintics / Q000138:chemical synthesis*; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D001522:Behavior, Animal / Q000187:drug effects; D001597:Benzylidene Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D002492:Central Nervous System Depressants / Q000138:chemical synthesis*; D005260:Female; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D008297:Male; D051379:Mice; D051381:Rats; D013329:Structure-Activity Relationship
D000871:Anthelmintics; D000893:Anti-Inflammatory Agents; D001597:Benzylidene Compounds; D002492:Central Nervous System Depressants; D007093:Imidazoles