title: Estimating the recombination frequency for the PTC-Kell linkage.
abstract: Two data sets are analyzed for linkage between the PTC and Kell blood group loci. The original report of close linkage for these loci was that of Conneally et al. (1976), where the maximum likelihood estimate of theta was 0.05. These two new data sets give a combined maximum likelihood estimate of theta m = f = 0.28. Estimating the recombination frequency for the sexes separately gave theta m = 0.29, theta f = 0.23. The combined maximum likelihood estimate over all published data sets including this report is theta m = f = 0.14, Zmax = 8.94. There is statistically significant evidence of heterogeneity among the published studies.
mesh_terms: D001789:Blood Group Antigens / Q000235:genetics*; D002874:Chromosome Mapping; D005260:Female; D006801:Humans; D007626:Kell Blood-Group System / Q000235:genetics*; D008126:Lod Score; D008297:Male; D010127:P Blood-Group System / Q000235:genetics; D011336:Probability; D011995:Recombination, Genetic
chemical_list: D001789:Blood Group Antigens; D007626:Kell Blood-Group System; D010127:P Blood-Group System