title: [Augmentation of NK activity in peripheral blood lymphocytes of cancer patients by intermittent GE-132 administration].
abstract: The natural killer (NK) activity of peripheral blood lymphocytes from 18 cancer patients was studied prior to and after multiple administration of organo-germanium compound (Ge-132). In successive oral administration of Ge-132 at a dose of 1000 mg/day for 10 days, NK-activity of patients was augmented at 3 days, but by 10 days, depression of NK activity was observed in all cases. In intermittent oral administration of Ge-132, however, more than half of the patients with augmented NK activity at day 3 maintained the high activity level at day 10. This result suggests the superiority of intermittent administration of Ge-132 for clinical use.
mesh_terms: D003110:Colonic Neoplasms / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D005857:Germanium / Q000494:pharmacology*; D006801:Humans; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology; D008175:Lung Neoplasms / Q000276:immunology*; D009942:Organometallic Compounds / Q000494:pharmacology*; D011422:Propionates; D013274:Stomach Neoplasms / Q000276:immunology*
chemical_list: D009942:Organometallic Compounds; D011422:Propionates; D005857:Germanium; C066750:propagermanium