Lactic acidosis, hyperglycaemia and convulsions following nalidixic acid overdosage.
A woman survived ingestion of 32 g nalidixic acid despite developing lactic acidosis, hyperglycaemia, convulsions and abnormal behaviour. The maximum recorded plasma concentration of nalidixic acid was 185 mg/l and the elimination half-life was 3.2 h. Carboxy-nalidixic acid was demonstrated in the plasma. Previously reported cases of nalidixic acid overdosage are reviewed.
D000138:Acidosis / Q000139:chemically induced*; D000328:Adult; D001519:Behavior / Q000187:drug effects; D005260:Female; D006801:Humans; D006943:Hyperglycemia / Q000139:chemically induced*; D007773:Lactates / Q000097:blood*; D009268:Nalidixic Acid / Q000097:blood / Q000506:poisoning*; D012640:Seizures / Q000139:chemically induced*; D012646:Self Administration / Q000009:adverse effects
D007773:Lactates; D009268:Nalidixic Acid