Cholecystokinin tetrapeptide, proglumide and open-field behavior in rats.
The effect of cholecystokinin tetrapeptide (CCK-4) was studied in an open field situation. CCK-4 increased locomotion and rearing and the effect was enhanced by proglumide, a selective antagonist of CCK-8. This is in sharp contrast to our earlier findings that CCK-8 decreased the open-field behavior and that proglumide completely blocked the effect. Thus, the effects of CCK-4 and CCK-8 appear to be opposite to each other in that one is excitatory and the other inhibitory to open-field responses.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003672:Defecation; D004357:Drug Synergism; D005755:Gastrins / Q000494:pharmacology*; D005973:Glutamine / Q000031:analogs & derivatives*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D011377:Proglumide / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013758:Tetragastrin / Q000494:pharmacology*
D005755:Gastrins; D013758:Tetragastrin; D005973:Glutamine; D011377:Proglumide