[Comparative bacteriostatic activity of ticarcillin, alone and combined with clavulanic acid, 5 cephalosporins and metronidazole against 100 strains of Bacteroides fragilis].
In vitro activity against 100 strains of Bacteroides fragilis of ticarcillin alone and combined with 4 or 8 mg of clavulanic acid was compared with those of cefoxitin, cefotaxime, ceftazidime, lamoxactam , ceftriaxone and metronidazole. The Cl 90 was 29.7 mg/l for ticarcillin alone, and 1.3 and 0.5 mg/l for ticarcillin combined with 4 and 8 mg of clavulanic acid respectively. Every strain was susceptible to ticarcillin combined with clavulanic acid (CMI less than or equal to 16 mg/l) and metronidazole (CMI less than or equal to 4 mg/l). Among the cephalosporins tested, lamoxactam (Cl 90 : 1 mg/l) was the most active, followed by cefotaxime (22.7 mg/l), cefoxitin (23 mg/l), ceftriaxone (51.2 mg/l) and ceftazidime (347 mg/l).
D001441:Bacteroides fragilis / Q000187:drug effects*; D002511:Cephalosporins / Q000494:pharmacology*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000494:pharmacology*; D004359:Drug Therapy, Combination; D008795:Metronidazole / Q000494:pharmacology*; D010406:Penicillins / Q000494:pharmacology*; D013982:Ticarcillin / Q000494:pharmacology*
D002511:Cephalosporins; D002969:Clavulanic Acids; D010406:Penicillins; D008795:Metronidazole; D019818:Clavulanic Acid; D013982:Ticarcillin
Activité bactériostatique comparée de la ticarcilline seule et associée à l'acide clavulanique, de cinq céphalosporines et du métronidazole vis-à-vis de cent souches de Bacteroides fragilis.