Disposition of intravenous glycofurol: effect of hepatic cirrhosis.
The disposition of intravenous glycofurol, a solvent for some drugs, was followed in nine male patients with hepatic cirrhosis. In comparison with age-matched controls, glycofurol clearance in the patients with cirrhosis was reduced 43% and terminal t 1/2 was prolonged 103%. There was no significant difference between the cirrhotic and control groups in volume of distribution.
D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008103:Liver Cirrhosis / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D011092:Polyethylene Glycols / Q000097:blood / Q000378:metabolism*
D011092:Polyethylene Glycols; C018557:glycofurol