title: Permselectivity: relation between foot process simplification and macromolecular configuration.
abstract: The simplification of the foot processes of the glomerular epithelial cells is the structural hallmark of proteinuria in nephrotic man and animals. The increased shear force in a filtrate funnelled within the lamina densa to simplified slit pores may decrease the friction of macromolecules which are prolate ellipsoids (cigar-shaped). The permeability of rigid long narrow proteins such as albumin, transferrin and immunoglobulin G may selectively increase when the slit pore is converted from a wide serpentine to a straight narrow space.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002199:Capillary Permeability; D002648:Child; D005260:Female; D006801:Humans; D007678:Kidney Glomerulus / Q000378:metabolism*; D008297:Male; D008433:Mathematics; D008875:Middle Aged; D008954:Models, Biological; D008970:Molecular Weight; D009402:Nephrosis, Lipoid / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*
chemical_list: D011506:Proteins