Trazodone-digoxin interaction in an animal model.
Serum digoxin concentrations have been reported to increase in two patients taking daily doses of trazodone. However, in a canine model, no elevation in serum digoxin concentration was found with combined trazodone-digoxin administration. The authors suggest that serum digoxin concentrations should be monitored in patients receiving trazodone and digoxin concomitantly.
D000818:Animals; D004077:Digoxin / Q000097:blood*; D004285:Dogs; D004347:Drug Interactions; D010879:Piperazines / Q000494:pharmacology*; D011863:Radioimmunoassay; D013997:Time Factors; D014196:Trazodone / Q000494:pharmacology*
D010879:Piperazines; D004077:Digoxin; D014196:Trazodone