title: Ivermectin as an antiparasitic agent in horses.
abstract: Ivermectin, described as 22,23-dihydroavermectin B1, was the compound chosen from the avermectin group of compounds for development as an antiparasitic agent in horses. A review of the literature indicates that parenteral administration in horses at 200 microgram/kg body mass is highly effective against the strongyles Strongylus vulgaris, Strongylus edentatus and triodontophorus spp., and adult and immature cyathostomes, including strains resistant to benzimidazole anthelmintics. Other nematodes controlled in horses include Oxyuris equi, Parascaris equorum, Trichostrongylus axei, and Habronema spp. Ivermectin is also highly effective against stomach bots (Gastrophilus spp.).
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007559:Ivermectin; D007783:Lactones / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D011247:Pregnancy
chemical_list: D000871:Anthelmintics; D007783:Lactones; D007559:Ivermectin