Genetic microcephaly in a pair of monozygous twins.
A pair of monozygotic female twins with true primary microcephaly is described. The autosomal-recessive nature of the disease is supported by the following: the twins are concordant for the disease; the parents, themselves normal, are related; the reduced skull dimensions were noted at birth; neurologic problems are absent; the karyotype is normal; the gestation and delivery were normal, without any history of influences capable of inducing microcephaly. A detailed dermatoglyphic study is given.
D003241:Consanguinity; D003878:Dermatoglyphics; D004200:Diseases in Twins; D005260:Female; D005808:Genes, Recessive; D006801:Humans; D007231:Infant, Newborn; D008831:Microcephaly / Q000235:genetics* / Q000473:pathology; D010375:Pedigree