Bone histomorphometry and vitamin D status after biliopancreatic bypass for obesity.
Bone histomorphometry and vitamin D status were investigated in 41 patients studied 1-5 yr after partial or total biliopancreatic bypass. Metabolic bone disease, characterized by defective mineralization, decreased bone formation rate, and increased surface extent of resorption, was present in 30 patients (73%). Nine patients (22%) were hypocalcemic, but serum 25-hydroxyvitamin D concentrations were normal in all 41 patients. We conclude that metabolic bone disease is common after biliopancreatic bypass and usually occurs in the absence of simple vitamin D deficiency. The pathogenesis of the bone disease is unclear.
D000293:Adolescent; D000328:Adult; D001659:Biliary Tract; D001835:Body Weight; D001847:Bone Diseases / Q000209:etiology; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology*; D002112:Calcifediol / Q000097:blood; D002118:Calcium / Q000097:blood; D005260:Female; D005500:Follow-Up Studies; D005743:Gastrectomy; D006801:Humans; D007082:Ileum / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009765:Obesity / Q000628:therapy*; D010179:Pancreas; D010710:Phosphates / Q000097:blood; D011183:Postoperative Complications; D012044:Regression Analysis; D014807:Vitamin D / Q000378:metabolism*
D010710:Phosphates; D014807:Vitamin D; D002112:Calcifediol; D002118:Calcium