Calcium source for excitation-contraction coupling in myocardium of nonhibernating and hibernating chipmunks.
The amplitude of the early plateau phase of the action potential and the slow action potential of cardiac muscle were much lower in hibernating chipmunks than in nonhibernating chipmunks. The frequency-dependent contraction was decreased in hibernating animals but increased in nonhibernating animals. Caffeine caused a negative inotropic effect in hibernating animals but a positive inotropic effect in nonhibernating animals. Ryanodine caused greater inhibition in hibernating animals than in nonhibernating animals. These results suggest that the respective roles of the sources of calcium for cardiac excitation-contraction coupling are changed during hibernation.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism / Q000502:physiology*; D002462:Cell Membrane / Q000378:metabolism; D005260:Female; D006321:Heart / Q000187:drug effects; D006605:Hibernation; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D012589:Sciuridae / Q000378:metabolism / Q000502:physiology*
D002110:Caffeine; D002118:Calcium