Incidence of radiation lymphomas in C57BL/6 mice is not promoted after intraperitoneal treatment with the phorbol ester tetradecanoylphorbol acetate.
Female C57BL/6 mice, given 4 X-ray irradiations each with 1.7 Gy, according to H.S. Kaplan and M.S. Brown (J. Natl. Cancer Inst., 13 (1952) 185-192) developed lethal lymphomas in more than 90%, 270 days after irradiation. Intraperitoneal application of tetradecanoylphorbol acetate (TPA), 30 ng/g, twice weekly for 240 days had no influence on survival of the animals and incidence of the malignant lymphomas.
D000818:Animals; D001344:Autopsy; D003043:Cocarcinogenesis; D005260:Female; D007274:Injections, Intraperitoneal; D008223:Lymphoma / Q000209:etiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D010704:Phorbols / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D010704:Phorbols; D013755:Tetradecanoylphorbol Acetate