title: Lichenoid lesions of the oral mucosa in rheumatoid arthritis patients treated with penicillamine.
abstract: Seven of 56 consecutive patients taking penicillamine for rheumatoid arthritis developed oral lesions that clinically and histologically resembled lichen planus. All 7 patients had rashes with prior gold therapy and 4 had rashes with penicillamine therapy. Lesions appeared between 3 and 12 months of therapy at an average dose of 400 mg/day and disappeared within 3 months of stopping the medication. Discontinuation of the drug for oral lichenoid lesions is not necessary. Topical steroids can be used for symptomatic relief.
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001623:Betamethasone / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008010:Lichen Planus / Q000139:chemically induced* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D001623:Betamethasone; D010396:Penicillamine