Morphine and the centrally-mediated inhibition of urinary bladder motility in the rat.
Systemic administration of morphine consistently inhibited spontaneous urinary bladder contractions in the ketamine-anesthetized rat. In addition, i.c.v. morphine and levorphanol but not dextrophan inhibited bladder function by a naloxone-sensitive mechanism. Naloxone alone increased the frequency of bladder contractions and intravesicular pressure. Systemic loperamide did not affect bladder function while N,N- diallylnormorphinium only reversed bladder inhibition by morphine when administered i.c.v. These observations suggest that morphine inhibits bladder activity by a central mechanism and that endogenous opioids are involved in the central control of bladder function.
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects*; D003864:Depression, Chemical; D004723:Endorphins / Q000502:physiology; D005260:Female; D007275:Injections, Intravenous; D007276:Injections, Intraventricular; D007279:Injections, Subcutaneous; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D001743:Urinary Bladder / Q000187:drug effects*
D004723:Endorphins; D009020:Morphine