Metabolism and excretion of orally administered dimethylarsinic acid in the hamster.
We administered a single po dose of dimethylarsinic acid ( DMAA ) to hamsters by stomach tube and determined the in vivo accumulation of the arsenic and its excretion in the urine and feces. It was shown that a part of the DMAA was further methylated to a trimethylarsenic compound (TMA). During the 24 hr following the administration of DMAA , a total of 80% was excreted in the urine and feces: 45% in the urine (made up of 67.9% DMAA and 32.0% TMA), and 34.7% in the feces (almost completely made up of DMAA but no TMA). The findings show that DMAA and the TMA are rapidly excreted and do not accumulate in the body.
D000284:Administration, Oral; D000818:Animals; D001151:Arsenic / Q000378:metabolism; D001152:Arsenicals / Q000378:metabolism*; D002101:Cacodylic Acid / Q000378:metabolism*; D006224:Cricetinae; D005243:Feces / Q000032:analysis; D008297:Male; D008647:Mesocricetus
D001152:Arsenicals; D002101:Cacodylic Acid; C020300:monomethylarsonic acid; D001151:Arsenic