The influence of prazosin and propranolol on serum lipids and atherosclerosis in standard fed pigs.
The influence of prazosin and propranolol on serum lipids and atherosclerosis was evaluated in standard fed pigs during a nine months experimental period. The incidence and severity of atherosclerotic lesions was very low, and no difference could be observed neither between the two drugs nor between the drug groups and the placebo group. Prazosin and propranolol induced no marked change in the serum lipid profile. The results could be explained by the very low fat content, 3.6 per cent, in the present standard diet.
D000818:Animals; D001011:Aorta / Q000473:pathology; D001161:Arteriosclerosis / Q000097:blood* / Q000209:etiology / Q000473:pathology; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL; D003331:Coronary Vessels / Q000473:pathology; D004041:Dietary Fats / Q000008:administration & dosage; D005260:Female; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D011224:Prazosin / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D011799:Quinazolines / Q000494:pharmacology*; D013552:Swine
D008076:Cholesterol, HDL; D004041:Dietary Fats; D008055:Lipids; D008075:Lipoproteins, HDL; D011799:Quinazolines; D002784:Cholesterol; D011433:Propranolol; D011224:Prazosin