[Changes in the respiratory muscles and their microcirculatory bed during exposure of the body to chronic hypoxia and its aftereffects].
Changes of the respiratory muscles have been studied under the effect of a rarefied atmosphere when the pressure is 560 mm Hg (2,500 m), 405 mm Hg (5,000 m), 286 mm Hg (7,500 m) and during the period of their aftereffect. The experimental group consists of 260 and the control group--of 130 white rats. Adaptation of the respiratory muscles to the effect of the rarefied atmosphere at the pressure of 560 mm Hg takes place mainly at the expense of certain functional changes of the microcirculatory bed and hypertrophy of the muscle fibers. The period of aftereffect is characterized with normalization of these phenomena. Adaptation of the respiratory muscles at the pressure of 405 mm Hg takes place at the expense of hypertrophy of the muscle fibers, small destructive changes and a complex rearrangement of the microcirulatory bed. During the period of aftereffect, by the 40th day no destructive changes are noted in the muscle tissue. The capillary bed undergoes some rearrangements by the 42d -56th day with increasing quantitative indices per area unit. This results in improvement of the muscles nutrition. In the respiratory muscles at the pressure 286 mm Hg, atrophic changes in the muscle fibers take place at certain stages of the experiment. Essential destructive changes are observed, rearrangement of the microcirculatory bed with decreasing convolution of the longitudinal capillaries and a decreasing number of the transversal capillaries are noted by the end of the experiment. During the period of aftereffect, by the 56th day, the external and internal intercostal muscles completely restore their structure, and in the diaphragm the destructive changes remain. By the same time, the microcirculatory bed becomes more rare at the expense of decreasing capillarization of the muscle fibers and a decreasing number of the transversal capillaries.
D000818:Animals; D003964:Diaphragm / Q000098:blood supply / Q000473:pathology*; D006984:Hypertrophy; D000860:Hypoxia / Q000473:pathology*; D007366:Intercostal Muscles / Q000098:blood supply / Q000473:pathology*; D008297:Male; D008833:Microcirculation / Q000473:pathology; D051381:Rats
Izmenenie dykhatel'nykh myshts i ikh mikrotsirkuliatornogo rusla pri vozdeĭstvii na organizm khronicheskoĭ gipoksii i v period ee posledeĭstvii.