title: Role of parietal pericardium in acute, severe mitral regurgitation in dogs.
abstract: Mitral regurgitation (MR) resulting from acute disruption of the mitral valve apparatus leads to serious hemodynamic sequelae. The lesion produces major elevation of left atrial (LA) and pulmonary artery pressures and decreases forward cardiac output. Clinical studies have shown hemodynamic patterns in acute MR similar to those seen in constrictive pericardial disease, suggesting that the pericardium serves to importantly limit cardiac filling in this condition. This hypothesis has not been tested in an animal model in which the intrapericardial pressure can be directly measured. In the present study intrapericardial and intracardiac pressures were measured in 8 dogs before and after the production of acute MR. After production of MR, mean LA pressure increased from 8 +/- 3 to 20 +/- 7 mm Hg (p = 0.004) and the peak LA V wave averaged 31 +/- 13 mm Hg. Mean right atrial pressure increased slightly, from 4 +/- 2 to 5 +/- 1 mm Hg (p less than 0.008). Intrapericardial pressure increased in each dog, but the increment was invariably small (1 +/- 2 to 3 +/- 2 mm Hg, p = 0.001) and there was no tendency to equalization of pressure between right- and left-sided cardiac chambers. Thus, the role of the pericardium in the immediate hemodynamic response to acute, severe MR is minor.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002302:Cardiac Output; D003251:Constriction, Pathologic; D004285:Dogs; D004562:Electrocardiography; D006439:Hemodynamics; D008944:Mitral Valve Insufficiency / Q000503:physiopathology*; D010496:Pericardium / Q000473:pathology / Q000503:physiopathology*; D011651:Pulmonary Artery / Q000503:physiopathology