[Temperature-dependent spontaneous platelet aggregation in polycythemia vera and primary thrombocythemia: a diagnostic criterion].
In twenty patients suffering from myeloproliferative syndromes (nine with polycythaemia vera, 11 with primary thrombocythaemia) platelet aggregation was tested following incubation of blood samples at 4 degrees C, room temperature, 30 degrees C and 37 degrees C. A spontaneous platelet aggregation following incubation at room temperature took place in 65% of patients with primary thrombocythaemia. At the two higher temperatures, positive results were seen in 72% and 92% of cases, respectively. Seven of nine patients (78%) showed a pathological spontaneous platelet aggregation at room temperature. Pathological spontaneous platelet aggregation at 30 degrees C occurred in eight of nine (89%) cases. The spontaneous platelet aggregation test is a simple method to diagnose primary thrombocythaemia and asymptomatic polycythaemia vera, the sensitivity of which increases considerably following incubation of blood samples at two and three different temperatures.
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010974:Platelet Aggregation; D011087:Polycythemia Vera / Q000097:blood*; D013696:Temperature; D013922:Thrombocytosis / Q000097:blood*
Die temperaturabhängige Spontanaggregation der Thrombozyten bei Polycythaemia vera und primärer Thrombozythaemie: Ein diagnostisches Kriterium.