Effects of cyclic 12-, 8-, and 6-carbon compounds on glutathione S-transferase activity.
The effects of feeding ICR/Ha mice cyclic 12-, 8-, and 6-carbon compounds on glutathione S-transferase (GST) activity in the liver, intestinal mucosa, and the forestomach were determined. The compounds used for this study were 1,5,9-trans,trans,cis- cyclododecatriene , 1,2-trans-5,6-trans-9,10-cis- cyclododecatriene -1,2-oxide, cyclododecanol , cyclododecene oxide, cyclododecane , 1,5- cyclooctadiene , cyclooctene oxide, cyclohexene, and cyclohexene oxide. The unsaturated cyclic 12-carbon compounds elicited the greatest increase in GST activity. Thus, feeding 1,5,9-trans,trans,cis- cyclododecatriene increased this activity almost 4-fold in the livers and the intestinal mucosa of experimental animals. Cyclic 8-carbon compounds were less effective and feeding the cyclic 6-carbon compounds did not result in any significant increase in GST activity. None of the compounds elicited increased GST activity in the fore-stomach. Previous studies have shown that compounds inducing increased GST activity can protect against chemical carcinogens. It remains to be determined whether the compounds identified in the present investigation as inducers of this enzyme system will have such protective capacities.
D000818:Animals; D003510:Cyclohexanes / Q000494:pharmacology; D003516:Cycloparaffins / Q000494:pharmacology*; D005260:Female; D005982:Glutathione Transferase / Q000378:metabolism*; D006838:Hydrocarbons / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000201:enzymology; D008099:Liver / Q000201:enzymology; D051379:Mice; D008813:Mice, Inbred ICR; D013270:Stomach / Q000201:enzymology; D013329:Structure-Activity Relationship
D003510:Cyclohexanes; D003516:Cycloparaffins; D006838:Hydrocarbons; D005982:Glutathione Transferase