Reversibility of blood-brain barrier dysfunction in acute hypertension induced by angiotensin.
The reversibility of blood-brain barrier (BBB) dysfunction was examined in rats after acute experimental hypertension. A short-lasting (less than or equal to 4 min) acute hypertension was produced by intravenous injection of 20 micrograms/kg angiotensin. Evans blue, the barrier tracer, was administered intravenously either prior to or at intervals of 3, 10, 20, 30, and 60 min after the angiotensin injection. It was observed that the BBB dysfunction showed a peak 30 min after the angiotensin injection. Three of six animals that received Evans blue 60 min after angiotensin administration showed extravasation of the tracer on gross inspection. We concluded that BBB dysfunction may remain even 60 min after an acute hypertensive episode of short duration.
D000208:Acute Disease; D000804:Angiotensin II; D000818:Animals; D001794:Blood Pressure; D001812:Blood-Brain Barrier; D005070:Evans Blue; D006973:Hypertension / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000804:Angiotensin II; D005070:Evans Blue