Effect of cyclo(leucyl-glycine) on [3H]spiroperidol binding in the corpus striatum and hypothalamus of spontaneously hypertensive rats.
Spontaneously hypertensive rats were found to have a greater density of specific [3H]spiroperidol binding sites in the corpus striatum and hypothalamus when compared to the normotensive Wistar-Kyoto rats. The apparent dissociation constant (Kd) for [3H]spiroperidol binding in the two groups of rats did not differ. Chronic administration of cyclo(leucyl-glycine), an analog derived from the hypothalamic peptide, melanotropin release inhibiting factor, decreased the enhanced number of [3H]spiroperidol binding sites in the striatum and hypothalamus of the hypertensive rats. These results further suggest that cyclo(leucyl-glycine) interacts with brain dopamine receptors, and that brain dopamine receptors may be involved in the etiology of hypertension.
D000818:Animals; D001665:Binding Sites / Q000187:drug effects; D002090:Butyrophenones / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D003342:Corpus Striatum / Q000378:metabolism* / Q000648:ultrastructure; D004151:Dipeptides / Q000494:pharmacology*; D006973:Hypertension / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D009479:Neuropeptides; D010456:Peptides, Cyclic; D051381:Rats; D011919:Rats, Inbred Strains; D011954:Receptors, Dopamine / Q000378:metabolism; D013134:Spiperone / Q000378:metabolism*
D002090:Butyrophenones; D004151:Dipeptides; D009479:Neuropeptides; D010456:Peptides, Cyclic; D011954:Receptors, Dopamine; D013134:Spiperone; C021166:cyclo(leucylglycine)