Inhibition of human lecithin cholesterol acyltransferase by monoterpenes.
The lecithin-cholesterol acyltransferase activity of human plasma was found to be inhibited by Rowachol, a proprietary mixture of pure monoterpenes. Menthol, the major ingredient in Rowachol (32%), and a number of other monoterpenes were found to inhibit the enzyme independently. Concentrations of monoterpenes required to achieve 50% inhibition were of the same order of magnitude as the cholesterol concentration present in the reaction mixture.
D002164:Camphor / Q000494:pharmacology; D002788:Cholesterol Esters / Q000378:metabolism; D004338:Drug Combinations / Q000494:pharmacology; D006801:Humans; D008610:Menthol / Q000494:pharmacology; D039821:Monoterpenes; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*; D013729:Terpenes / Q000494:pharmacology*
D002788:Cholesterol Esters; D004338:Drug Combinations; D039821:Monoterpenes; D013729:Terpenes; D008610:Menthol; C018655:Rowachol; D002164:Camphor; D007862:Phosphatidylcholine-Sterol O-Acyltransferase