title: Validation of the dual radiotracer method for quantitative In-111 platelet scintigraphy.
abstract: We have developed a simple in vivo scintigraphic technique that permits accurate quantitative comparison of intravascular platelet deposition in blood vessels of similar size. Regional count information from scintigraphic images of In-111 platelets and Tc-99m red blood cells is used to determine the ratio of radioactivity in the thrombus relative to that in the blood. Multiplication of this ratio by the percent injected dose (%ID) of In-111 per ml of blood yields a quantity (%ID index) that is directly proportional to the %ID of In-111 platelets in the thrombus as measured in vitro (r = .879, p less than 0.005). This technique is well suited for quantitative studies of scintigraphically detectable platelet deposition in both animals and in man.
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000000981:diagnostic imaging*; D004195:Disease Models, Animal; D007204:Indium; D010976:Platelet Count / Q000379:methods; D011817:Rabbits; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013927:Thrombosis / Q000000981:diagnostic imaging; D013997:Time Factors
chemical_list: D011868:Radioisotopes; D007204:Indium