Is N-acetylglutamate a short-term regulator of urea synthesis?
A method is described for determining N-acetylglutamate as glutamate. N-Acetylglutamate content of hepatocytes from 48 h-starved rats is high. It shows no parallelism with rates of urea synthesis from glutamine. We question its accepted function as a short-term regulator of urea synthesis.
D000818:Animals; D005260:Female; D005971:Glutamates / Q000032:analysis / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism; D066298:In Vitro Techniques; D008099:Liver / Q000032:analysis / Q000166:cytology / Q000378:metabolism*; D008722:Methods; D051381:Rats; D011919:Rats, Inbred Strains; D014508:Urea / Q000096:biosynthesis*
D005971:Glutamates; D005973:Glutamine; D014508:Urea; C016195:N-acetylglutamic acid