Effect of 3-(2-morpholinoethylamino)-4-methyl-6-phenyl pyridazine dihydrochloride (minaprine) on plasma cortisone levels of physostigmine treated rats.
3-(2- morpholinoethylamino )-4-methyl-6-phenyl pyridazine dihydrochloride (minaprine), has recognized clinical activity against inhibition of action. In rats, this substance antagonizes the increase of plasma corticosterone levels caused by physostigmine injection. The mechanism of this action is discussed.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood*; D008297:Male; D010830:Physostigmine / Q000494:pharmacology*; D011724:Pyridazines / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D000928:Antidepressive Agents; D011724:Pyridazines; C006149:minaprine; D010830:Physostigmine; D000109:Acetylcholine; D003345:Corticosterone