Effect of oral amrinone on platelet function and survival.
Amrinone is a cardiotonic agent associated with reversible thrombocytopenia in 20% to 50% of patients. The mechanism of thrombocytopenia is not known and it is not clear whether this effect represents a high-frequency idiosyncratic reaction or an overt manifestation of a toxic effect on platelet survival. We prospectively evaluated the effect of oral amrinone on platelet function and survival in seven subjects who participated in a clinical trial of chronic oral amrinone therapy. There was no consistent effect on either platelet function or platelet survival. Data suggest that amrinone does not have a uniform effect on platelet survival and that the development of thrombocytopenia may represent an idiosyncratic reaction.
D000284:Administration, Oral; D000328:Adult; D000631:Aminopyridines / Q000378:metabolism / Q000633:toxicity*; D000676:Amrinone; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D002316:Cardiotonic Agents / Q000633:toxicity*; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D013921:Thrombocytopenia / Q000139:chemically induced
D000631:Aminopyridines; D002316:Cardiotonic Agents; D000676:Amrinone