Diabetes-associated, ventromedial hypothalamic neuronal degeneration in the Chinese hamster.
The hypothalamic neurons of the diabetic Chinese hamster exhibited degradation associated with the hyperglycemic, diabetic condition as compared with matched control animals. In particular, neurons in the arcuate and ventromedial nuclei exhibited characteristic indications of neuronal death associated with diabetes. These studies indicate that hypothalamic depopulation induced by diabetes is characterized by neuronal degradation in the nuclei associated with CNS regulation of pancreatic function.
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000648:ultrastructure; D006224:Cricetinae / Q000235:genetics*; D003412:Cricetulus / Q000235:genetics*; D003920:Diabetes Mellitus / Q000235:genetics / Q000473:pathology*; D005260:Female; D007033:Hypothalamus, Middle / Q000473:pathology* / Q000648:ultrastructure; D009410:Nerve Degeneration; D009474:Neurons / Q000648:ultrastructure