Gas--liquid chromatographic assay of aminoglutethimide and a high-performance liquid chromatographic assay for its acetyl metabolite in biological fluids.
A rapid, sensitive and selective gas--liquid chromatographic assay for aminoglutethimide is described. The same extraction procedure may be employed prior to a high-performance liquid chromatographic assay for acetamidoglutethimide which is also detailed. Both assays are suitable for the study of the pharmacokinetics of aminoglutethimide and acetamidoglutethimide in biological fluids in man.
D000616:Aminoglutethimide / Q000031:analogs & derivatives / Q000032:analysis* / Q000097:blood / Q000652:urine; D001826:Body Fluids / Q000032:analysis*; D002849:Chromatography, Gas / Q000379:methods; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007700:Kinetics; D012463:Saliva / Q000032:analysis
D000616:Aminoglutethimide; C036163:N-acetylaminoglutethimide