Human leukocyte antigen in genodermatosis.
Tissue typing performed on the lymphocytes of 41 patients, including: 23 patients with ichthyosis (15 of autosomal dominant and 8 of the x-linked variety; 8 patients with tuberous sclerosis (epiloia); and 10 patients with acrodermatitis enteropathica (AEP). In addition, tissue typing was performed for a control group of 80 healthy unrelated subjects of the same ethnic origin as the patients. A significant increase of A2 antigen or its crossreacting antigen A28 was detected among the three diseases studied. A significant increase of HLA-A2 antigen was found in autosomal dominant ichthyosis, while the x-linked variety showed significant association with HLA-Cw2. A significant association with HLA-A28 antigen was noticed in both epiloia and AEP. The suggested mechanisms of such association may be referred to as incidental genetic linkage with mutants causing disease or deficiency.
D000169:Acrodermatitis / Q000235:genetics / Q000276:immunology; D005767:Gastrointestinal Diseases / Q000235:genetics / Q000276:immunology; D006680:HLA Antigens / Q000032:analysis / Q000235:genetics*; D006801:Humans; D007057:Ichthyosis / Q000235:genetics / Q000276:immunology; D012871:Skin Diseases / Q000235:genetics* / Q000276:immunology; D014402:Tuberous Sclerosis / Q000235:genetics / Q000276:immunology
D006680:HLA Antigens