title: Effects of desipramine on clinical liver function tests.
abstract: Results of liver function tests in 46 depressed patients changed little during treatment with desipramine and were uncorrelated with drug plasma levels. The findings suggest that tricyclic-associated hepatitis, rather than being dose dependent, is an uncommon, idiosyncratic phenomenon.
mesh_terms: D000328:Adult; D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D003866:Depressive Disorder / Q000188:drug therapy; D003891:Desipramine / Q000031:analogs & derivatives / Q000097:blood / Q000627:therapeutic use / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged
chemical_list: D003891:Desipramine; C028653:2-hydroxydesipramine