title: [Treatment of bone infections with gentamicin-containing acrylic cement beads. Prognostic value of the study of the suction drainage fluid].
abstract: Treatment of bone infections with gentamicin-PMMA beads is an adjunct to conventional surgery. Early failures occurred in a number of cases, due to technical problems, such as incomplete debridement, residual alloplastic material, or gentamicin-resistant pathogens. To evaluate short term results of the method, clinical and bacteriological pre-therapy data were compared with results obtained two and six weeks after surgery, in 25 patients. Gentamicin concentrations, gentamicin levels/MBC for gentamicin, and bactericidal activity in secretions collected from suction drainage were not correlated with outcome. Cultures from the drains were the best parameters: cultures remained positive throughout follow-up in patient with poor clinical results.
mesh_terms: D000328:Adult; D000368:Aged; D004343:Drug Implants; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008768:Methylmethacrylates; D008875:Middle Aged; D009985:Orthopedics; D010000:Osteitis / Q000188:drug therapy*; D011379:Prognosis; D013997:Time Factors
chemical_list: D004343:Drug Implants; D005839:Gentamicins; D008768:Methylmethacrylates
vernacular_title: Le traitement des infections osseuses par les billes de ciment acrylique à la gentamicine. Valeur pronostique de l'étude des liquides des drains de redon.