[Effect of benzodiazepine tranquilizers on the ischemic focus and redistribution of blood flow in the ischemic myocardium].
It has been shown in experiments on dogs with acute coronary insufficiency (coronary artery constriction and electrical pacing of the right atrium) that the tranquilizers diazepam (0.1 and 0.3 mg/kg) and chlordiazepoxide (1.0 mg/kg) do not change the epicardial electrogram as compared to control. The drugs increase the ratio of the retrograde coronary circulation in the ligated coronary artery to the circulation in intact areas of the myocardium, that may evidence circulatory redistribution in favour of the affected myocardial area.
D000818:Animals; D002707:Chlordiazepoxide / Q000627:therapeutic use*; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy*; D003975:Diazepam / Q000627:therapeutic use*; D004285:Dogs
D002707:Chlordiazepoxide; D003975:Diazepam
Vliianie trankvilizatorov benzodiazepinovogo riada na ochag ishemii i pereraspredelenie krovotoka v ishemizirovannom miokarde.