Effects of ouabain and furosemide on saliva secretion induced by sympathomimetic agents in isolated, perfused rat submandibular glands.
The presence of 10(-3) M ouabain or furosemide in the perfusate inhibited saliva secretion induced by either isoproterenol (10(-5) M) or phenylephrine (10(-5) M) from isolated rat submandibular glands and caused characteristic alterations in the electrolyte composition of saliva.
D000818:Animals; D005665:Furosemide / Q000494:pharmacology*; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D010042:Ouabain / Q000494:pharmacology*; D010656:Phenylephrine / Q000494:pharmacology; D011188:Potassium / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012463:Saliva / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism; D013363:Submandibular Gland / Q000378:metabolism*; D013566:Sympathomimetics / Q000494:pharmacology*
D013566:Sympathomimetics; D010656:Phenylephrine; D010042:Ouabain; D005665:Furosemide; D012964:Sodium; D007545:Isoproterenol; D011188:Potassium