[Effect of preoperative radiation on the success rate in the transplantation of human kidney cancer into thymus-aplastic nude mice].
The authors investigated the influence of a preoperative irradiation on the rate of successful implantations and the growth behavior of human hypernephromas implanted into nude mice. No successful implantation was observed in hypernephromas preirradiated with a dose of 2000 rd, which was also confirmed by histologic examinations. The rate of successful implantation of 17 non-preirradiated hypernephromas (10/17) is below that of the total group, and the rate of successful implantation in serial passage (6/17 = 35%) is markedly inferior. The clinical observation that the incidence of local recurrences is reduced by a preoperative irradiation is explained by our experimental findings.
D000230:Adenocarcinoma / Q000532:radiotherapy*; D000818:Animals; D006085:Graft Survival / Q000528:radiation effects; D006801:Humans; D007680:Kidney Neoplasms / Q000532:radiotherapy*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D014183:Transplantation, Heterologous
Einfluss der präoperativen Vorbestrahlung auf die Angangsrate menschlicher Nierenkarzinome in der thymusaplastischen Nacktmaus.