title: Critical test evaluations of oxfendazole and trichlorfon: effectiveness of a paste formulation in the horse.
abstract: Critical tests were performed on 6 horses to evaluate the antiparasitic effectiveness of oxfendazole given in combination with trichlorfon in a paste formulation. Treatments were given orally as a single dose. The rates of active ingredient administration were 2.5 and 40 mg/kg of body weight for oxfendazole and trichlorfon, respectively. The combined activities of the 2 antiparasitic compounds proved 100% efficacious in the removal of adult Strongylus vulgaris, S edentatus, Oxyuris equi, and Parascaris equorum. Fourth stage O equi, and 2nd and 3rd instars of Gasterophilus nasalis also were completely removed. Second and 3rd stage instars of G intestinalis were removed at the rates of 98.1% and 98.8%, respectively. Nematodes of the "small strongyle" category were removed at the combined rate of 97.0%. Pronounced larvicidal effects of the test formulation were demonstrated via culturing fecal nematode eggs during the trial. Untoward effects of treatment were not seen in any of the trial animals.
mesh_terms: D000818:Animals; D001196:Ascariasis / Q000188:drug therapy / Q000662:veterinary; D001562:Benzimidazoles / Q000008:administration & dosage / Q000627:therapeutic use*; D004175:Diptera; D004338:Drug Combinations; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D010123:Oxyuriasis / Q000188:drug therapy / Q000662:veterinary; D010270:Parasite Egg Count; D010272:Parasitic Diseases / Q000188:drug therapy; D010273:Parasitic Diseases, Animal; D013319:Strongyle Infections, Equine / Q000188:drug therapy; D014236:Trichlorfon / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D001562:Benzimidazoles; D004338:Drug Combinations; D014236:Trichlorfon; C011030:oxfendazole