Changes in mitochondrial proteins during neuroblastoma differentiation.
The evolution of three major mit-proteins was followed in neuroblastoma cells cultured in different conditions of differentiation. 1 methyl cyclohexane carboxylic acid (CCA) was found to stimulate the synthesis of the three mit-protein markers. This result, compared to the effects of oligomycin, an inhibitor of mitochondrial function, favours the hypothesis that CCA induces in vitro neurogenesis through a general metabolic alteration.
D000818:Animals; D001921:Brain / Q000196:embryology / Q000378:metabolism; D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D008715:Methionine / Q000378:metabolism; D051379:Mice; D008928:Mitochondria / Q000378:metabolism*; D009447:Neuroblastoma / Q000378:metabolism* / Q000473:pathology; D014176:Protein Biosynthesis
D003509:Cyclohexanecarboxylic Acids; C027655:1-methylcyclohexanecarboxylic acid; D008715:Methionine; D004121:Dimethyl Sulfoxide