title: [Frequent occurrence of contrast medium reactions in urograms following accidents in childhood].
abstract: Between 30.8.1973 and 30.11.1982 3.200 intravenous urograms were performed with Urografin 76% in patients aged from 0 to 16 years. With regard to the incidence of contrast medium reactions, there was a distinct difference between children who had suffered accidents previously and those who had not: among the former it was 4.24%, in the latter 13.51%. The number of cases appears large enough to rule out randomness. Lalli 's neurodysregulation theory offers the best basis for explaining this highly significant difference: the increased permeability of the blood-brain barrier as a result of microlesions in secondary brain trauma and the increased response of the autonomic nervous system to contrast media which occurs as a result could be a significant factor. However, it does not fully explain the incidents observed. It would be desirable to carry out checks at other clinics and in adults.
mesh_terms: D000293:Adolescent; D001812:Blood-Brain Barrier; D002648:Child; D002675:Child, Preschool; D003287:Contrast Media / Q000009:adverse effects*; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D014567:Urography; D014947:Wounds and Injuries / Q000150:complications*
chemical_list: D003287:Contrast Media; D003973:Diatrizoate; D003974:Diatrizoate Meglumine
vernacular_title: Gehäuftes Auftreten von Kontrastmittelreaktionen bei Urogrammen nach Unfällen im Kindesalter.