A new model for investigation of transluminal recanalization: human atherosclerotic coronary artery xenografts.
A model for testing transluminal recanalization techniques was developed. Human atherosclerotic arteries were transplanted in dogs and evaluated by angiographic and histologic study within a 12-week period. An inflammatory response was most intense within the first 2 weeks. By 12 weeks, no inflammation was noted. The model has several advantages: (1) The pathologic characteristics are those of a human coronary artery. (2) Thrombus formation is frequent, with progression to a well organized dense fibrocellular vascular occlusion within 4 to 12 weeks. (3) The arterial occlusion resembles human vascular disease. (4) The vascular occlusions are readily accessible with standard catheterization technique. (5) The model is easy to produce within a short period. This model has been used to evaluate laser recanalization of vascular obstructions.
D000792:Angiography; D000818:Animals; D001161:Arteriosclerosis / Q000473:pathology; D002404:Catheterization; D017023:Coronary Angiography; D003331:Coronary Vessels / Q000473:pathology / Q000637:transplantation*; D004285:Dogs; D005263:Femoral Artery / Q000000981:diagnostic imaging / Q000473:pathology / Q000637:transplantation; D013927:Thrombosis / Q000209:etiology