[Efficacy of polymeric 239Pu removal by liposome-encapsulated pentacin].
Liposome-incapsulated pentacine (DTPA) removes intracellular polimeric 239Pu and colloidal hydroxide of polymeric 239Pu from a rat body in the amounts 2- and 4 times, respectively, exceeding those eliminated by free DTPA. However the amount of 239Pu removed decreases sharply with increasing 239Pu hydrolysation and polymerization. It is concluded that the effectiveness of 239Pu removal depends on the physico-chemical status of the radionuclide and its interaction with the biosubstrate rather than on the amount of DTPA entering the cells.
D000818:Animals; D003666:Decontamination / Q000379:methods*; D008081:Liposomes / Q000008:administration & dosage*; D008297:Male; D004369:Pentetic Acid / Q000627:therapeutic use*; D011005:Plutonium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D008081:Liposomes; D011005:Plutonium; D004369:Pentetic Acid
Effektivnost' vyvedeniia polimernogo 239Pu pentatsinom, inkapsulirovannym v liposomakh.