A three-step synthesis of (+/-)-beta-methyleneaspartic acid.
A simplified, three-step synthesis for (+/-)-beta- methyleneaspartic acid is described. Condensation of diethyl malonate with ethyl pyruvate gives 1,1,2- tricarbethoxyprop -1-ene, which is alpha-aminated with chloramine to give 1-amino-1,1,2- tricarbethoxyprop -2-ene. The latter is hydrolyzed in acid to give the title compound.
D001224:Aspartic Acid / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D008722:Methods
D001224:Aspartic Acid; C036683:beta-methyleneaspartate