Göteborg Metoprolol Trial: effects on arrhythmias.
During the initial hospitalization, ventricular fibrillation (VF) developed in 6 metoprolol-treated patients (0.9%) vs 17 placebo-treated patients (2.4%) after inclusion in the study (p = 0.035). There were 6 episodes of VF in the metoprolol group compared with 41 episodes in the placebo group (p less than 0.001). During the same period, 14 metoprolol-treated patients had treated ventricular tachycardia vs 26 placebo-treated patients (p = 0.076). Similar favorable results were found when the incidence of severe ventricular arrhythmias during the first rehospitalization within the 3-month double-blind treatment period was analyzed.
D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000188:drug therapy / Q000209:etiology*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006323:Heart Arrest / Q000209:etiology; D006760:Hospitalization; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy*; D013614:Tachycardia, Paroxysmal / Q000209:etiology; D014693:Ventricular Fibrillation / Q000209:etiology
D008012:Lidocaine; D008790:Metoprolol