Mobilization of canine hemopoietic stem cells by pyran copolymer (NSC 46015).
Pyran copolymer (NSC 46015), a divinyl ether maleic anhydride of broad spectrum molecular weight, was infused into six normal mongrel dogs. The effect on canine blood and bone marrow colony forming units in culture (CFU-C) was followed over an 11-day period. Significant elevation of circulating CFU-c was noted 2 days after pyran infusion; normalization occurred by day 7 postinfusion. Bone marrow CFU-C were decreased 2 days and 5 days after pyran administration. A further increase in circulating CFU-C was noted when pyran was administered twice, 5 days apart. The mobilizing effect of pyran copolymer appears promising enough to warrant further exploration of blood as a source of hemopoietic stem cells for transplantation purposes.
D000818:Animals; D004285:Dogs; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000378:metabolism; D010477:Perfusion; D011108:Polymers / Q000494:pharmacology*; D011713:Pyran Copolymer / Q000008:administration & dosage / Q000494:pharmacology*; D013997:Time Factors
D011108:Polymers; D011713:Pyran Copolymer