title: Wall shear stress during pulsatile flow distal to a normal porcine aortic valve.
abstract: The shear stress at the wall has been of interest as one of the possible fluid dynamic factors that may be damaging in the region of prosthetic valves. The purpose of this study was to measure the axial wall shear stresses in the region of a 29 mm tissue annulus diameter porcine stent mounted prosthetic aortic valve (Hancock, Model 242). Studies were performed in an in vitro pulse duplicating system. The axial wall shear stress was calculated from velocities obtained near the wall with a laser Doppler anemometer. The largest axial wall shear stress was 29 dyn cm-2 and it occurred at the highest stroke volume used (80 ml). At a stroke volume of 50 ml, the largest axial wall shear stress was 17 dyn cm-2 and at a stroke volume of 35 ml, it was 15 dyn cm-2. Stresses of these magnitudes are far below those reported to be damaging to the endothelial surface. These stresses may be high enough, however, to affect platelet function.
mesh_terms: D001021:Aortic Valve / Q000503:physiopathology*; D001705:Bioprosthesis; D006350:Heart Valve Prosthesis; D006439:Hemodynamics; D006801:Humans; D008953:Models, Anatomic; D012212:Rheology