title: [Changes in the content of the thiol form of the acetylation coenzyme in the liver during administration of vitamin B3-active compounds to intact and locally irradiated animals].
abstract: A local exposure of mouse head to gamma-rays caused phase changes in CoASH content of the liver. The administration of D-pantothenate-Ca and D-pantethine increased the level of CoASH in the liver of exposed animals; calcium D-homopantothenate did not influence the co-enzyme content. It is suggested that pantothenate and pantethine act like vitamins while the influence of homopantothenate is associated with the effects of calcium ions.
mesh_terms: D000818:Animals; D003065:Coenzyme A / Q000378:metabolism*; D005260:Female; D008099:Liver / Q000187:drug effects / Q000201:enzymology* / Q000528:radiation effects; D051379:Mice; D010204:Pantetheine / Q000031:analogs & derivatives / Q000494:pharmacology*; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*; D013438:Sulfhydryl Compounds / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D013438:Sulfhydryl Compounds; C016030:pantogab; D010205:Pantothenic Acid; D010204:Pantetheine; D005680:gamma-Aminobutyric Acid; C005425:pantethine; D003065:Coenzyme A
vernacular_title: Izmeneniia soderzhaniia tiolovoĭ formy koénzima atsilirovaniia v pecheni pri vvedenii B3-vitaminoaktivnykh soedineniĭ intaktnym i lokal'no obluchennym zhivotnym.