Mechanical hypothesis of sperm penetration.
Sperm have generally been supposed to penetrate the zona pellucida surrounding the mammalian egg with the aid of a protease, acrosin. Difficulties associated with this view are discussed and an alternative, mechanical hypothesis introduced. The calculated force exerted by individual sperm is too small to permit the rupture of any but the weakest of secondary chemical bonds. Mechanical progress through the zona must rely on stress relaxation in a viscoelastic medium. The known properties of the zona appear to be consistent with such a mechanism of penetration.
D000176:Acrosin / Q000378:metabolism; D000818:Animals; D005260:Female; D005306:Fertilization; D008297:Male; D008433:Mathematics; D008954:Models, Biological; D013084:Sperm-Ovum Interactions; D013094:Spermatozoa / Q000502:physiology; D015044:Zona Pellucida / Q000502:physiology
D000176:Acrosin