Amphetamine with experience promotes recovery of locomotor function after unilateral frontal cortex injury in the cat.
In cats, a single dose of D-amphetamine (AMP) given at 10 days after unilateral frontal cortex ablation produced an immediate and enduring (60 day) acceleration of beam-walking ability compared to saline control animals. Four doses of AMP at 4-day intervals promoted recovery faster than a single dose of AMP. Subjects with no beam-walking experience while under AMP intoxication were not different from saline controls after two doses of AMP. However, after 4 doses these cats recovered significantly faster than saline controls and were comparable to animals that received AMP and experience under the drug.
D000818:Animals; D002395:Catecholamines / Q000378:metabolism; D002415:Cats; D003913:Dextroamphetamine / Q000494:pharmacology*; D004292:Dominance, Cerebral / Q000187:drug effects; D004334:Drug Administration Schedule; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D009044:Motor Cortex / Q000187:drug effects; D009048:Motor Skills / Q000187:drug effects*; D009416:Nerve Regeneration / Q000187:drug effects*; D013003:Somatosensory Cortex / Q000187:drug effects
D002395:Catecholamines; D003913:Dextroamphetamine