[Role of the locus coeruleus in the development of cerebrovascular disorders in acute myocardial ischemia].
Experiments on rats were made to examine the total cerebral blood flow during locus coeruleus (LC) stimulation, acute myocardial ischemia and in the presence of acute myocardial ischemia after LC precoagulation . LC electric stimulation caused a decrease in the cerebral blood flow. The most profound cerebrovascular disorders were observed in animals with acute myocardial ischemia without LC precoagulation and were followed by cardiac arrhythmias. Cerebrovascular hemodynamic disorders occurring in acute myocardial ischemia were prevented by LC coagulation. It is suggested that the cerebrovascular disorders are consequent on the formation in the LC of the hyperactive determinant structure and play a role of a secondary pathogenetic factor in heart regulation disorders.
D000208:Acute Disease; D000818:Animals; D002561:Cerebrovascular Disorders / Q000209:etiology*; D003327:Coronary Disease / Q000150:complications*; D008125:Locus Coeruleus / Q000502:physiology*; D008297:Male; D051381:Rats
Rol' "golubogo piatna" v razvitii tsebrovaskuliarnykh narusheniĭ pri ostroĭ ishemii miokarda.