Effect of coal tar on cutaneous aryl hydrocarbon hydroxylase induction and anthralin irritancy.
The inflammatory dose-response to topical anthralin and whole skin aryl hydrocarbon hydroxylase (AHH) activity were measured before and 24 h after application of a coal tar solution to the uninvolved skin of patients with psoriasis. The inflammatory response to anthralin decreased and total AHH activity increased after the tar treatment. A possible explanation is that anthralin or an irritant product is metabolized by AHH activity in the skin. Induction of AHH by coal tar increases its removal and reduces anthralin irritancy.
D000328:Adult; D000873:Anthracenes / Q000009:adverse effects*; D000875:Anthralin / Q000009:adverse effects*; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis*; D003033:Coal Tar / Q000494:pharmacology*; D003877:Dermatitis, Contact / Q000201:enzymology* / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity / Q000201:enzymology* / Q000517:prevention & control; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D006801:Humans; D007509:Irritants; D008297:Male; D011565:Psoriasis / Q000188:drug therapy / Q000201:enzymology; D012867:Skin / Q000187:drug effects / Q000201:enzymology*
D000873:Anthracenes; D007509:Irritants; D003033:Coal Tar; D001189:Aryl Hydrocarbon Hydroxylases; D000875:Anthralin