Mixed micells: a new problem-free solution for omega-123I-heptadecanoic acid in comparison.
The most commonly used reagents for solubilization of 123I fatty acids have very serious drawbacks. Human serum albumin solubilizes the fatty acid only slowly and TWEEN 80 is not free of stability problems. Furthermore adverse reactions in human applications cannot be excluded. In comparison, the newly introduced mixed micells look very favourable: fast solubilization, good stability and no adverse reactions. Biodistribution experiments on rats show an adequate performance of the micells . Hitherto this solution has been applied in more than 200 patients without any complication.
D000818:Animals; D003102:Colloids; D005227:Fatty Acids / Q000378:metabolism; D007457:Iodine Radioisotopes; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008823:Micelles; D009206:Myocardium / Q000378:metabolism; D011136:Polysorbates / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012996:Solutions; D013961:Thyroid Gland / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution
D003102:Colloids; D005227:Fatty Acids; D007457:Iodine Radioisotopes; D008823:Micelles; D011136:Polysorbates; D012996:Solutions; C013102:margaric acid