Fibrinogen and fibrin in strong magnetic fields. Complementary results and discussion.
When fibrin polymerizes in a strong magnetic field, it can be highly oriented. The structural diffraction study of the oriented polymer becomes thus possible. The magnetic birefringence can also be used to study the development of the polymer Fibrinogen in solution is weakly oriented in high magnetic fields. In this work we present complementary results and discussion. The validity of the comparison of the orientation parameters of fibrinogen and fibrin with those of other orientable known biological structures is discussed. The orientation of fibrin formed from fibrin monomer solution is compared to that of fibrin formed by the action of thrombin on fibrinogen. The conditions to obtain highly oriented fibrin gels suitable for three dimensional structure studies are also briefly discussed.
D000818:Animals; D001718:Birefringence; D002417:Cattle; D005337:Fibrin / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D007700:Kinetics; D046911:Macromolecular Substances; D008280:Magnetics; D011487:Protein Conformation
D046911:Macromolecular Substances; D005337:Fibrin; D005340:Fibrinogen