Prevention by progesterone of cervicovaginal lesions in neonatally estrogenized BALB/c mice.
Instillation of progesterone into the vaginal lumen of BALB/c mice treated neonatally with 25 micrograms 17 beta-estradiol resulted in a significant decrease in vaginal concretions (P less than 0.025), vaginal cornification (P less than 0.025) and vaginal lesions (P less than 0.05).
D000818:Animals; D000831:Animals, Newborn; D002114:Calcinosis / Q000139:chemically induced / Q000517:prevention & control; D002584:Cervix Uteri / Q000187:drug effects* / Q000473:pathology; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D004958:Estradiol / Q000633:toxicity*; D005260:Female; D007642:Keratosis / Q000139:chemically induced / Q000517:prevention & control; D051379:Mice; D008807:Mice, Inbred BALB C; D011374:Progesterone / Q000008:administration & dosage* / Q000627:therapeutic use; D014621:Vagina / Q000187:drug effects* / Q000473:pathology; D014623:Vaginal Diseases / Q000139:chemically induced / Q000517:prevention & control
D011374:Progesterone; D004958:Estradiol