title: Carcinogenicity of petroleum lubricating oil distillates: effects of solvent refining, hydroprocessing, and blending.
abstract: Certain refining processes were investigated to determine their influence on the dermal carcinogenic activity of petroleum-derived lubricating oil distillates. Specifically, the effects of solvent refining, hydroprocessing, a combination of both processes, and the blending of oils processed using each technique were evaluated in standard mouse skin-painting bioassays. The refining process used as well as the level or severity of treatment greatly influenced the carcinogenic outcome of processed lubricating oils. Solvent refining at severities normally used appeared to eliminate carcinogenicity. In contrast, hydroprocessing alone at mild levels of treatment was successful only in reducing the carcinogenic potency; severe hydroprocessing conditions were necessary to eliminate carcinogenic activity without the use of additional refining processes. Carcinogenic activity could also be eliminated by following moderate solvent refining with mild hydroprocessing. Blending of hydroprocessed oils with solvent-refined oils resulted in a substantial reduction or even elimination of carcinogenic activity. However, the degree of protection obtained varied with the particular distillates used and appeared largely dependent on the inherent biological activity of the hydroprocessed oil.
mesh_terms: D000818:Animals; D051379:Mice; D008809:Mice, Inbred C3H; D009784:Occupational Diseases / Q000139:chemically induced*; D009821:Oils / Q000506:poisoning*; D010578:Petroleum / Q000506:poisoning*; D012878:Skin Neoplasms / Q000139:chemically induced*; D014783:Viscosity
chemical_list: D009821:Oils; D010578:Petroleum