Toxic effect of lead on the testes of rat.
Biochemical and histopathological studies were performed on the testes of rats after feeding lead acetate at a concentration of 0.25, 0.50 and 1.0 g/l over a period of 60 days. Testicular atrophy along with cellular degeneration was conspicuous at 1 g/l. Furthermore, high cholesterol concentration and significantly low ascorbic acid concentration were found in the testes at the same dosage. The lowest dose (0.25 g/l) did not produce any significant morphological and biochemical alteration whereas 0.5 g/l resulted in partial inhibition of spermatogenesis.
D000622:Aminolevulinic Acid / Q000652:urine; D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D007854:Lead / Q000378:metabolism / Q000633:toxicity*; D008297:Male; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology
D007854:Lead; D000622:Aminolevulinic Acid; D002784:Cholesterol; D001205:Ascorbic Acid