[Use of liposomes as a nonspecific detoxifier in the crush syndrome].
The possibility of parenteral detoxification was studied in dogs with the experimental crush syndrome. Infusion of lecithin liposomes (25 and 50 mg/kg) prevented the development of postcompression toxemia and hemodynamic disorders characteristic for endogenous intoxication. The use of the nonspecific parenteral sorbent lecithin liposomes permitted the maintenance of an adequate function of the animals' cardiovascular system for 5 hours after decompression.
D000818:Animals; D003444:Crush Syndrome / Q000188:drug therapy*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D008081:Liposomes / Q000008:administration & dosage*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D010743:Phospholipids / Q000627:therapeutic use*; D012772:Shock, Septic / Q000188:drug therapy; D012774:Shock, Traumatic / Q000188:drug therapy*; D013997:Time Factors; D014115:Toxemia / Q000188:drug therapy
D008081:Liposomes; D010743:Phospholipids
Ispol'zovanie liposom v kachestve nespetsificheskogo detoksikatora pri sindrome dlitel'nogo razdavlivaniia.