Serum erythromycin concentration in sheep fed two diets.
Serum erythromycin concentrations following a single IV injection (12.5 mg/kg) were compared in 6 sheep during feeding of a grass hay diet and a concentrate diet. The concentrate diet resulted in a mean decrease of at least 1 pH unit in forestomach fluid, but did not significantly alter either the serum drug concentrations or half-life. Variable antibacterial activity was present in forestomach fluid as early as 1 or 2 hours after injection. This study indicates that ion-trapping in forestomach fluid as a result of normal dietary changes does not require therapeutic dosage adjustment.
D000821:Animal Feed; D000818:Animals; D004917:Erythromycin / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D006207:Half-Life; D006863:Hydrogen-Ion Concentration; D008297:Male; D012756:Sheep / Q000097:blood*; D013279:Stomach, Ruminant / Q000378:metabolism
D004917:Erythromycin