Age-related decrease in apomorphine modulation of acetylcholine release from rat striatal slices.
Release of [3H]acetylcholine ( [3H]ACh) was assessed in striatal slices from mature, middle-aged and senescent Wistar rats 8, 12 and 24 months of age, respectively. There was an age-related decline in basal release of [3H]ACh as a function of age which was correlated with a decline in accumulation of [3H]ACh. However, the most striking finding was the failure of apomorphine to inhibit KCl-induced [3H]ACh release in the senescent (24 months) animals. Striatal dopaminergic receptor losses in senescence apparently produce several subsequent changes in striatal function which ultimately result in the decline of motor-behavioral function.
D000109:Acetylcholine / Q000378:metabolism*; D000375:Aging; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D008297:Male; D009474:Neurons / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D001058:Apomorphine; D000109:Acetylcholine; D004298:Dopamine