title: Generalized staphylococcal scalded skin syndrome in an anephric boy undergoing hemodialysis.
abstract: Generalized staphylococcal scalded skin syndrome (SSSS) is a toxin-related epidermolytic disease that predominantly affects previously healthy infants and children younger than 5 years. In contrast, the majority of the reported adult cases have been associated with underlying diseases, suggesting that immunosuppression and renal insufficiency are important predisposing conditions for this age group. We report herein a case of adult-type SSSS in an anephric 10-year-old boy. Patients undergoing hemodialysis who have chronic renal failure may be uniquely predisposed to the SSSS by virtue of their decreased glomerular filtration rate, associated uremic immunodeficiency, and a high incidence of Staphylococcus aureus bacteremia.
mesh_terms: D000818:Animals; D002648:Child; D006801:Humans; D007165:Immunosuppression Therapy; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000473:pathology / Q000628:therapy; D008297:Male; D051379:Mice; D006435:Renal Dialysis; D018805:Sepsis / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D012867:Skin / Q000473:pathology; D012874:Skin Diseases, Infectious / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D013203:Staphylococcal Infections / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D013211:Staphylococcus aureus; D013577:Syndrome