Adsorption, distribution and elimination of chloroquine in the presence of aspirin when administered into rabbits.
The absorption, distribution and elimination of chloroquine were studied in rabbits upon oral administration of chloroquine with aspirin. The time-lag, half-life of absorption and absorption rate constant obtained in both cases were significantly different (P less than 0.01) whereas the half-life of elimination and the elimination rate constant were not significantly different (P greater than 0.01). The results showed that absorption was delayed when aspirin was simultaneously administered with chloroquine but the distribution and elimination of chloroquine were not affected by the presence of aspirin.
D000284:Administration, Oral; D000327:Adsorption; D000818:Animals; D001241:Aspirin / Q000008:administration & dosage / Q000494:pharmacology*; D002738:Chloroquine / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D006207:Half-Life; D007700:Kinetics; D008297:Male; D011817:Rabbits
D002738:Chloroquine; D001241:Aspirin