title: Tetrahymena. Adaptation to high iron.
abstract: Fe-starved ciliates Tetrahymena thermophila cease to multiply at Fe(III) concentrations above 10 microM in a synthetic nutrient medium lacking a good iron chelator such as citrate. If, however, the Fe(III) concentration is gradually increased over a series of subcultivations the cells will tolerate up to 300 microM Fe(III). Our experiments rule out the possibility of genetic selection of Fe-tolerant clones and suggest a physiological type of adaptation.
mesh_terms: D000064:Acclimatization; D000818:Animals; D002712:Chlorides; D003470:Culture Media; D005290:Ferric Compounds / Q000633:toxicity*; D007501:Iron / Q000633:toxicity*; D007700:Kinetics; D013768:Tetrahymena / Q000187:drug effects / Q000254:growth & development*
chemical_list: D002712:Chlorides; D003470:Culture Media; D005290:Ferric Compounds; D007501:Iron; C024555:ferric chloride