Local anaesthetic effect of antiarrhythmic drugs and human sperm immobilization: mechanism and application of the interrelationship.
Sperm immobilizing activity of three class I antiarrhythmic drugs, quinidine, procainamide, mexiletine, one adrenoceptor blocking drug, labetalol and one calcium channel blocking drug, diltiazem was measured with a trans-membrane migration method. All these drugs immobilized human sperm. Local anaesthetic effect is the underlying mechanism for these drugs to inhibit sperm motility. Sperm immobilization could be a screening test for the local anaesthetic effect of antiarrhythmic drugs.
D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology*; D004110:Diltiazem / Q000494:pharmacology; D006801:Humans; D007741:Labetalol / Q000494:pharmacology; D008297:Male; D008801:Mexiletine / Q000494:pharmacology; D011342:Procainamide / Q000494:pharmacology; D011802:Quinidine / Q000494:pharmacology; D013078:Sperm Immobilizing Agents
D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D013078:Sperm Immobilizing Agents; D008801:Mexiletine; D004110:Diltiazem; D011802:Quinidine; D011342:Procainamide; D007741:Labetalol