Ethanol induces hyper and hypoglycemia in both fasted and nonfasted rats dependent on the ambient temperature.
An experiment was undertaken to characterize the influence of ambient temperature on ethanol-induced glycemic alterations in rats. Animals under two different feeding conditions (nonfasted or 48-hr fasted) were IP injected with 4.0 g/kg of ethanol. Blood glucose and body temperature were measured before, 90 and 180 min after drug administration. The rats were tested under ambient temperatures of 16, 21 and 32 degrees C. Fed animals with a mean pre-drug glycemia of near 105 mg/100 ml presented a variation of blood glucose ranging from 50 mg/100 ml at 16 degrees C to 140 mg/100 ml at 32 degrees C. The glycemia from fasted rats, with a starting value of 70 mg/100 ml ranged from 20 to 115 mg/100 ml at 16 and 32 degrees C, respectively. It was concluded that the administration of ethanol can render nonfasted as well as fasted rats hypo or hyperglycemic, depending upon the environmental temperature.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001831:Body Temperature; D000431:Ethanol / Q000494:pharmacology*; D005215:Fasting; D006943:Hyperglycemia / Q000503:physiopathology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012149:Restraint, Physical; D013696:Temperature
D001786:Blood Glucose; D000431:Ethanol