title: Invasion of bone into porous fiber metal implants in cats.
abstract: Bone ingrowth in porous Ti-6Al-4V implants in feline femurs was assessed for the amount and composition 4, 12 and 26 weeks after implantation. During the first 12 weeks there was a rapid ingrowth that levelled out during the ensuing weeks. Bone had penetrated the implants to an average depth of 0.5 mm over their entire surface at 26 weeks. The ingrown bone was deficiently mineralized at 4 and 12 weeks, but reached full mineralization at 26 weeks. A low calcium to phosphorus ratio persisted at all observation times. The ingrown tissue was compared to bone filling drill holes that had been made in the trochanters contralaterally to the implants. By means of radioactive strontium, the mineral deposits in the holes and implants could be compared. The overall results indicate that bone ingrowth in a porous implant and bone healing are similar processes both qualitatively and quantitatively.
mesh_terms: D000497:Alloys; D000818:Animals; D001861:Bone Regeneration; D001842:Bone and Bones / Q000032:analysis / Q000502:physiology*; D002118:Calcium / Q000032:analysis; D002415:Cats; D005269:Femur / Q000502:physiology; D006909:Hydroxyproline / Q000032:analysis; D008297:Male; D019736:Prostheses and Implants; D013997:Time Factors; D014025:Titanium; D014945:Wound Healing
chemical_list: D000497:Alloys; C031462:titanium alloy (TiAl6V4); D014025:Titanium; D006909:Hydroxyproline; D002118:Calcium