Pulmonary hemorrhage and acute renal failure in a patient with mixed connective tissue disease.
Mixed connective tissue disease (MCTD) is considered to have a benign clinical course. Recently, renal disease has been recognized as a frequent complication (20%). This report describes a patient with MCTD who developed pulmonary hemorrhage and acute renal failure. The renal biopsy, in addition to a long-standing membranous nephropathy, revealed a tubulointerstitial nephritis. Immunofluorescent and electron microscopy showed immune complex deposition along the tubular basement membrane. Life-threatening, immune complex-mediated events can occur in the course of MCTD, manifested as pulmonary hemorrhage and tubulointerstitial nephritis.
D058186:Acute Kidney Injury / Q000209:etiology* / Q000473:pathology; D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis; D005260:Female; D006470:Hemorrhage / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008171:Lung Diseases / Q000209:etiology* / Q000473:pathology; D008947:Mixed Connective Tissue Disease / Q000150:complications* / Q000473:pathology; D009395:Nephritis, Interstitial / Q000209:etiology
D000936:Antigen-Antibody Complex