Quantitative predictivity of carcinogenicity for four short-term parameters, evaluated in rat liver: alkaline DNA fragmentation, autoradiographic repair, DNA adducts, preneoplastic nodules.
The possibility of the study of a quantitative correlation between short-term tests and carcinogenicity, instead of a qualitative one, is discussed. Four tests related to the target organ, rat liver, were considered: alkaline DNA fragmentation, DNA repair, DNA adducts and the formation of preneoplastic nodules. All the four tests showed a similar level of correlation with carcinogenic potency (r approximately equal to 0.4). With this level of correlation, the dispersion of the data appeared too large to offer a meaningful degree of quantitative predictivity of carcinogenicity, in reference to a single test. It appeared however, that the use of a battery of two or three independent short-term tests, with the above level of simple correlation, could generate a multiple correlation high enough to be potentially useful for some degree of quantitative predictivity of carcinogenic potency.
D000588:Amines / Q000633:toxicity; D000818:Animals; D001391:Azo Compounds / Q000633:toxicity; D002273:Carcinogens / Q000378:metabolism / Q000633:toxicity*; D004247:DNA / Q000378:metabolism*; D004260:DNA Repair; D006834:Hydrazines / Q000633:toxicity; D006846:Hydrocarbons, Halogenated / Q000633:toxicity; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008113:Liver Neoplasms / Q000473:pathology; D009183:Mycotoxins / Q000633:toxicity; D009602:Nitrosamines / Q000633:toxicity; D011083:Polycyclic Compounds / Q000633:toxicity; D051381:Rats
D000588:Amines; D001391:Azo Compounds; D002273:Carcinogens; D006834:Hydrazines; D006846:Hydrocarbons, Halogenated; D009183:Mycotoxins; D009602:Nitrosamines; D011083:Polycyclic Compounds; D004247:DNA