Stereologic studies on mitochondrial configuration in mitochondria of immobilized mice muscle.
The effect of long-term (3 weeks) immobilization on mice skeletal (m. gastrocnemius) and heart muscles was investigated. Morphometric determinations were carried out for analysis surface and volume parameters in mitochondria. The ultrastructural visual evaluation of mitochondria showed that there are no difference between control and experimental groups. Morphometric data obtained from stereological analysis were shown that mitochondria in immobilized skeletal and heart muscles represent tendency of transformation to low-energy states (condensed state). Based upon data obtained in this study we recommend that these changes in mitochondria there are reversible.
D000818:Animals; D004734:Energy Metabolism; D007103:Immobilization; D051379:Mice; D008854:Microscopy, Electron; D008929:Mitochondria, Heart / Q000648:ultrastructure; D008931:Mitochondria, Muscle / Q000378:metabolism / Q000648:ultrastructure*; D009133:Muscular Atrophy / Q000473:pathology