title: Effects of reinnervation upon electrical membrane properties of normal and paralyzed muscles.
abstract: Resting membrane potentials (RMP) and resistance to tetrodotoxin (TTX) have been compared in denervated rat soleus muscles and muscles reinnervated with tetrodotoxin-inactive nerves for periods of 15-18 days. RMP's of the two muscle groups exhibited the same low values typical of denervated muscles. Similarly, comparable values of TTX-resistance were found in the two muscle groups, although exceptions with slightly lower values in the innervated-paralyzed muscles were noted. It is concluded that muscle reinnervation restores to normal the membrane properties altered by denervation essentially through the return of muscle activity.
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D008297:Male; D008564:Membrane Potentials; D009121:Muscle Denervation; D009132:Muscles / Q000294:innervation* / Q000503:physiopathology; D010243:Paralysis / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D013779:Tetrodotoxin / Q000494:pharmacology
chemical_list: D013779:Tetrodotoxin