title: Organophosphate detoxification related to induced hepatic microsomal enzymes of chickens.
abstract: Detoxification of the organophosphate malathion in its activated form (malaoxon) was increased in livers of chickens given microsomal enzyme inducers (beta-naphthoflavone, 3-methylcholanthrene, butylated hydroxytoluene (BHT), or polychlorinated biphenyls). Positive correlations between inducer and microsomal enzyme activity were demonstrated for beta-naphthoflavone with demethylation of p-nitroanisole and for 3-methylcholanthrene and for BHT with cytochrome P450/448 and cytochrome b5. Malaoxon detoxification decreased in correlation with decreases in quantities of cytochrome P450/448 in birds fed a low-protein diet. Prediction of malaoxon detoxification was aided by using enzyme activities as dependent variables in the regression model, although only in birds given BHT were all of the 5 enzymes necessary for providing the best predictive model.
mesh_terms: D000818:Animals; D001140:Aroclors / Q000494:pharmacology; D001571:Benzoflavones / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002645:Chickens / Q000378:metabolism*; D020111:Chlorodiphenyl (54% Chlorine); D019388:Cytochrome P-450 CYP1A2; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D003580:Cytochromes / Q000378:metabolism; D004044:Dietary Proteins / Q000008:administration & dosage; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008658:Inactivation, Metabolic; D008099:Liver / Q000378:metabolism*; D008294:Malathion / Q000378:metabolism*; D008748:Methylcholanthrene / Q000494:pharmacology; D008862:Microsomes, Liver / Q000201:enzymology*; D019324:beta-Naphthoflavone
chemical_list: D001140:Aroclors; D001571:Benzoflavones; D003580:Cytochromes; D004044:Dietary Proteins; D020111:Chlorodiphenyl (54% Chlorine); D002084:Butylated Hydroxytoluene; D008748:Methylcholanthrene; D019324:beta-Naphthoflavone; D003577:Cytochrome P-450 Enzyme System; C017170:Cyp1a2 protein, rat; D019388:Cytochrome P-450 CYP1A2; D008294:Malathion