title: Carcinogenesis by nitrosomorpholines, nitrosooxazolidines and nitrosoazetidine given by gavage to Syrian golden hamsters.
abstract: Five cyclic nitrosamines, four containing oxygen in the ring, were administered by gavage to groups of 20 male Syrian golden hamsters. After administration of very similar doses, nitrosomorpholine, nitroso-2-methylmorpholine and nitroso-5-methyl-1,3-oxazolidine caused the animals to die with tumors after similar times, but nitrosomorpholine induced mainly tumors of the nasal cavity (and a few of the trachea), whereas the 2-methyl derivative induced tumors of the nasal cavity and liver. While nitroso-1,3-oxazolidine and its 5-methyl derivative both induced liver tumors (but no tumors in the nasal cavity) those induced by the former compound took much longer to kill the animals. Nitrosoazetidine, a liver carcinogen in rats, but which had been reported to be inactive in hamsters, did induce tumors of the liver in 30% of hamsters after a much larger dose than the other cyclic nitrosamines.
mesh_terms: D000818:Animals; D002273:Carcinogens; D006224:Cricetinae; D008113:Liver Neoplasms / Q000139:chemically induced; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009602:Nitrosamines / Q000633:toxicity*; D009603:Nitroso Compounds / Q000633:toxicity*; D009669:Nose Neoplasms / Q000473:pathology; D013329:Structure-Activity Relationship; D014134:Tracheal Neoplasms / Q000473:pathology
chemical_list: D002273:Carcinogens; D009602:Nitrosamines; D009603:Nitroso Compounds; C005145:nitrosoazetidine; C027753:N-nitroso-5-methyl-1,3-oxazolidine; C035920:N-nitroso-1,3-oxazolidine; C002741:N-nitrosomorpholine