Antibody-mediated enhancement of rabies virus infection in a mouse macrophage cell line (P388D1).
The suggestion that antibodies might enhance rabies virus infection of macrophages through opsonization of immune complexes was tested in vitro by adaptation of the rapid fluorescent focus inhibition technique for the examination of a macrophage cell line (P388D1). Some enhancement of rabies virus infection was shown. The relationship between such enhancement with the 'early death' phenomenon and its occurrence in vivo is discussed.
D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D000920:Antibody-Dependent Cell Cytotoxicity; D000936:Antigen-Antibody Complex / Q000276:immunology; D002460:Cell Line; D007106:Immune Sera / Q000276:immunology; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D009895:Opsonin Proteins / Q000276:immunology; D011818:Rabies / Q000276:immunology*; D011820:Rabies virus / Q000276:immunology*; D014776:Virus Cultivation
D000914:Antibodies, Viral; D000936:Antigen-Antibody Complex; D007106:Immune Sera; D009895:Opsonin Proteins