Studies on the release of solubilized drugs from ointment bases. Part 8: The effect of emulsifiers on pharmaceutical availability of ethanolamine, diethanolamine and morpholine from emulsive ointments.
The effect of addition of lanolin and Span 60 to white vaseline and of their concentration on the pharmaceutical availability of monoethanolamine , diethanolamine and morpholine was investigated. The emulsifier type and its concentration exercise an influence on constant release rates. The liberation of the investigated amines proceeds at almost the same speed as therapeutic substances within the limits from 10 to 30%. The release half life periods showed the same dependence in relation to the content of investigated substances in the ointment.
D001682:Biological Availability; D002626:Chemistry, Pharmaceutical; D004655:Emulsions; D019856:Ethanolamine; D004983:Ethanolamines / Q000378:metabolism*; D005079:Excipients / Q000494:pharmacology*; D007809:Lanolin / Q000494:pharmacology; D009025:Morpholines / Q000378:metabolism*; D010577:Petrolatum; D013501:Surface-Active Agents / Q000494:pharmacology
D004655:Emulsions; D004983:Ethanolamines; D005079:Excipients; D009025:Morpholines; D013501:Surface-Active Agents; D019856:Ethanolamine; D007809:Lanolin; D010577:Petrolatum; C037574:morpholine; C020283:diethanolamine