Nerve regeneration in exogenous cerebral ganglioside-treated rats.
Intraperitoneal injection of 50 mg/kg of exogenous cerebral gangliosides resulted in a statistically significant (23%) increase (compared with saline-injected controls) in the tetanic isometric tension of the rat plantaris muscle 7 days after section of the fourth lumbar root (L4). In a second experiment, intraperitoneal-injected exogenous gangliosides were found to have no effect on axonal regeneration following cryo-injury to the sciatic nerve. These results lead to the possibility of an early enhancement of muscular collateral sprouting in partially denervated muscles under an intraperitoneal-injected ganglioside mixture treatment.
D000818:Animals; D001369:Axons / Q000187:drug effects; D005677:G(M1) Ganglioside / Q000494:pharmacology; D005732:Gangliosides / Q000008:administration & dosage / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008297:Male; D009416:Nerve Regeneration / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains
D005732:Gangliosides; C021298:ganglioside, GD1a; C033851:ganglioside, GD1b; D005677:G(M1) Ganglioside