title: [Antitoxic action of cobamamide in experimental hepatitis].
abstract: Antitoxic properties of cobamamide, a coenzymic form of vitamin B12, were studied in experimental toxic hepatitis induced by CCl4. The data obtained as a result of the assessment of the bromosulfalene test and activity of sorbitol dehydrogenase and alanine aminotransferase point to a demonstrable hepatoprotective action of cobamamide. Normalization of the indicators studied evidences that the drug intensifies the recovery processes occurring in the liver of rabbits with toxic hepatitis.
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D002252:Carbon Tetrachloride Poisoning / Q000188:drug therapy*; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000188:drug therapy*; D003038:Cobamides / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D007064:L-Iditol 2-Dehydrogenase / Q000097:blood; D011817:Rabbits; D013448:Sulfobromophthalein; D013997:Time Factors
chemical_list: D000931:Antidotes; D003038:Cobamides; D013448:Sulfobromophthalein; D007064:L-Iditol 2-Dehydrogenase; D000410:Alanine Transaminase; C000913:cobamamide
vernacular_title: Ob antitoksicheskom deĭstvii kobamamida pri éksperimental'nom gepatite.