title: The influence of nutrient density of broiler rations on the effective dose of anticoccidial drugs.
abstract: Anticoccidial drugs were added to diets formulated with a nutrient density of 1479 kcal/lb and 24% protein or with 80% of those energy and protein levels (low density) to determine whether rate of feed intake influences efficacy of drugs in broilers infected with coccidiosis. In four experiments with monensin, broilers receiving 60 or 100 ppm of monensin in the lower-density ration consumed more feed per unit of gain but gained less weight than those on the control diet. Coccidiosis (Eimeria tenella) was better controlled by 60 ppm of monensin in the low-density diet than in the high-density diet. There was some evidence of a similar efficacy-enhancing effect with nicarbazin, salinomycin, and lasalocid but not with robenidine. When drug intake was calculated as mg/kg of weight gain, there was a strikingly higher rate of intake of most drugs in the low-density diet, accounting for the apparent increase in activity. These results suggest that in countries where nutrient density of feeds varies significantly from those used in the United States, some compensation in levels of certain feed additives might be considered.
mesh_terms: D000821:Animal Feed; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002645:Chickens; D003048:Coccidiosis / Q000378:metabolism / Q000517:prevention & control / Q000662:veterinary*; D003049:Coccidiostats / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D004734:Energy Metabolism; D005503:Food Additives / Q000008:administration & dosage; D008297:Male; D008985:Monensin / Q000008:administration & dosage; D011201:Poultry Diseases / Q000517:prevention & control*; D012370:Robenidine / Q000008:administration & dosage
chemical_list: D003049:Coccidiostats; D005503:Food Additives; D012370:Robenidine; D008985:Monensin