[Relation between the prolongation of the anti-inflammatory activity of liposome-encapsulated hydrocortisone and liposome composition in experimental arthritis].
Experiments on rabbits with arthritis have demonstrated the possibility of a 10-fold decrease in the dose of hydrocortisone acetate incorporated into liposomes, administered intraarticularly as compared with a commercial drug in the form of suspension. The antiinflammatory effect was found to be appreciably prolonged (up to 5-6 days) upon the use of dipalmitoylphosphatidylcholine liposomes with 20 mol% cholesterol. Hydrocortisone had a prolongation effect (about 1-2 days) in the lipid phase of multilamellar liposomes from egg lecithin, dimyristoylphosphatidylcholine and distearoylphosphatidylcholine.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D001168:Arthritis / Q000139:chemically induced / Q000188:drug therapy*; D006820:Hyaluronic Acid; D006854:Hydrocortisone / Q000627:therapeutic use*; D008081:Liposomes / Q000008:administration & dosage* / Q000032:analysis; D011107:Polylysine; D011817:Rabbits; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D008081:Liposomes; D011107:Polylysine; D006820:Hyaluronic Acid; D006854:Hydrocortisone
Zavisimost' prolongatsii protivospalitel'noĭ aktivnosti gidrokortizona, zakliuchennogo v liposomy, ot ikh lipidnogo sostava pri éksperimental'nom artrite.