title: Takaokamycin, a new peptide antibiotic produced by Streptomyces sp.
abstract: A new peptide antibiotic named takaokamycin was isolated from a fermentation broth of Streptomyces sp. AC-1978, a soil isolate. It exhibits antibacterial activity against some Gram-positive bacteria. The molecular weight was found to be 1,130 on the basis of elemental analysis, FD-mass spectrum and 1H and 13C NMR. Acid hydrolysate of takaokamycin contains isoleucine, threonine and unidentified amino acids.
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification*; D023181:Antimicrobial Cationic Peptides; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008837:Micrococcus / Q000187:drug effects; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000032:analysis
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D010455:Peptides; C042540:takaokamycin