title: [Effects of phosphatidylserine in an experimental model of generalized epilepsy].
abstract: The possible antiepileptic activity of PS has been tested in a model of generalized epilepsy induced by penicillin in the cat. In acute experiments, topical application to the cortex of PS (from 20 mg/ml to 50 mg/ml) produced a reverse in the polarity of the spike and wave complex and, sometimes, a decrease in the voltage as well as a morphological deformation of s-w bursts. Chronic intraperitoneal administration of PS induced a decrease of the epileptic burst frequency. The effect was already apparent after 14 days and of greater extent after 21 days. Finally the antiepileptic effect of 0,2-0,5 mg/Kg diazepam, given in a single dose during the maximal epileptic activity resulted markedly reinforced in animals chronically treated with PS.
mesh_terms: D000818:Animals; D002415:Cats; D004569:Electroencephalography; D004827:Epilepsy / Q000139:chemically induced*; D010406:Penicillins; D010718:Phosphatidylserines / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D010406:Penicillins; D010718:Phosphatidylserines
vernacular_title: Effetti della fosfatidilserina in un modello sperimentale di epilessia generalizzata.