title: Chronic lymphocytic leukaemia terminating in acute myelofibrosis.
abstract: Acute myelofibrosis developed in a patient with longstanding chronic lymphocytic leukaemia who had been treated with alkylating agents and total body irradiation. The case is discussed in the context of acute non-lymphoid leukaemias occurring in chronic lymphocytic leukaemia with special reference to megakaryoblastic variants.
mesh_terms: D000208:Acute Disease; D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000628:therapy; D008198:Lymph Nodes / Q000473:pathology; D055728:Primary Myelofibrosis / Q000150:complications* / Q000473:pathology; D013154:Spleen / Q000473:pathology