title: Fluoride-stimulated adenylate cyclase activity in rat brain following chronic treatment with psychotropic drugs.
abstract: Chronic treatment with imipramine and reserpine increased fluoride-stimulated activity of adenylate cyclase in homogenates of cerebral cortex and "limbic" forebrain of the rat. Concomitant treatment with lithium counteracted this effect, while lithium alone had no effect on the activity of adenylate cyclase.
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002540:Cerebral Cortex / Q000201:enzymology; D004347:Drug Interactions; D004789:Enzyme Activation / Q000187:drug effects; D005459:Fluorides / Q000494:pharmacology*; D007099:Imipramine / Q000494:pharmacology; D008032:Limbic System / Q000201:enzymology; D008094:Lithium / Q000494:pharmacology; D008297:Male; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012110:Reserpine / Q000494:pharmacology
chemical_list: D011619:Psychotropic Drugs; D012110:Reserpine; D008094:Lithium; D000262:Adenylyl Cyclases; D007099:Imipramine; D005459:Fluorides