Sodium N-methyl-D-glucamine dithiocarbamate and cadmium intoxication.
The sodium and ammonium salts of N-methyl-D-glucamine dithiocarbamate were prepared and their usefulness as antidotes for cadmium intoxication investigated. This chelating agent was found to be effective in both acute and repeated exposure cadmium poisoning. A single intraperitoneal injection of sodium N-methyl-D-glucamine dithiocarbamate (NaNMG-DTC), administered at a level greater than 1.1 mmol/kg body weight, protects against a normally lethal (greater than 95%) dose of cadmium chloride (10 mg CdCl2/kg body weight) and results in a subsequent dose-dependent decrease in the liver and kidney burdens of cadmium ion. In repeated exposure cadmium intoxication, repeated administration of NaNMG-DTC can result in substantial reductions in both the kidney (71%) and the liver (40%) levels of cadmium. The LD50 of the compound was not determined, but single injections of 26.6 mmol/kg body weight (injectate volume 1.0 ml) are well tolerated in mice.
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D002104:Cadmium / Q000378:metabolism; D002105:Cadmium Poisoning / Q000188:drug therapy*; D002219:Carbamates / Q000627:therapeutic use* / Q000633:toxicity; D002614:Chelating Agents / Q000627:therapeutic use*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013012:Sorbitol / Q000031:analogs & derivatives*; D013113:Spin Labels; D013737:Testis / Q000187:drug effects; D013859:Thiocarbamates
D000931:Antidotes; D002219:Carbamates; D002614:Chelating Agents; D013113:Spin Labels; D013859:Thiocarbamates; D002104:Cadmium; D013012:Sorbitol; C041262:N-methyl-D-glucamine dithiocarbamate