[Effect of cholesterol oxidation products, polyunsaturated fatty acids and the synthetic antioxidant ionol on experimental hypercholesterolemia in rabbits].
Oral administration to rabbits of purified commercial cholesterol entailed a substantial delay in the development of hypercholesterolemia as compared with estimates obtained in a group of animals given analogous doses of crude cholesterol. Administration of polyunsaturated fatty acids from hydrobiont lipids led to a dramatic suppression of hypercholesterolemia at the late stages of experiment (2.5 months). After administering ethyl esters of polyunsaturated fatty acids combined with the synthetic antioxidant ionol the level of blood plasma cholesterol did not differ significantly from that in intact animals. It is suggested that minor oxidation products contained by commercial cholesterol produce a hypercholesterolemic effect.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D002784:Cholesterol / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D006937:Hypercholesterolemia / Q000209:etiology* / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D011817:Rabbits
D000975:Antioxidants; D005231:Fatty Acids, Unsaturated; D002084:Butylated Hydroxytoluene; D002784:Cholesterol
Vliianie produktov okisleniia kholesterina, polinenasyschennykh zhirnykh kislot i sinteticheskogo antioksidanta ionola na éksperimental'nuiu giperkholesterinemiiu u krolikov.