Effect of lipid peroxidation on microtubular protein.
CCl4 and ADP-Fe3+ determine an increased microsomal lipid peroxidation in liver tissue which is related to an impairment of the tubulin molecule in the case of CCl4 while no alteration is evident with ADP-Fe3+. Such difference could be explained in terms of different intermediate or end products towards which the tubulin molecule shows a different susceptibility.
D000244:Adenosine Diphosphate / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology; D003078:Colchicine / Q000378:metabolism; D005609:Free Radicals; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D014404:Tubulin / Q000378:metabolism*
D005609:Free Radicals; D008054:Lipid Peroxides; D014404:Tubulin; C029936:adenosine diphosphate-ferric chelate; D000244:Adenosine Diphosphate; D002251:Carbon Tetrachloride; D003078:Colchicine