Ketamine-induced modification of photic evoked potentials in the superior colliculus of hooded rats.
The effects of ketamine on photic evoked potentials, recorded from the superior colliculus, were determined in hooded rats. Animals were given intraperitoneal injections of saline, or of 1, 10, 50 or 100 mg ketamine/kg body weight on separate days. Evoked potentials were recorded at 5, 20, 40 and 60 min following injection. Individual components in an early positive complex were augmented by the 100 mg/kg dose. Following administration of the 50 and 100 mg/kg doses, a positive spike (latency of 53 msec) emerged from the middle of a negative wave. A second positive spike (latency of 65 msec) also became prominent at these doses. Late oscillatory potentials were slightly augmented by the 100 mg/kg dose of ketamine. The relationship between these effects of ketamine on photic evoked potentials, and the postanaesthetic psychological manifestations of ketamine, is yet to be determined.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D007649:Ketamine / Q000494:pharmacology*; D008297:Male; D010775:Photic Stimulation; D051381:Rats; D013477:Superior Colliculi / Q000502:physiology*
D007649:Ketamine