Decrease in saturation density of mammalian carcinoma cell culture during exposure to bestatin, a clinically applicable agent.
Bestatin, one of the small molecular products of Streptomyces olivoreticuli , and a potential immunostimulator, was shown to decrease the saturation density of murine carcinoma cell culture. The finding may indicate a possibility of direct action of bestatin upon cancer cells presumably resulting in cancer cell redifferention .
D000230:Adenocarcinoma / Q000473:pathology*; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D007930:Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008325:Mammary Neoplasms, Experimental / Q000473:pathology*; D051379:Mice; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D007930:Leucine; C012211:ubenimex