Preoperative dilatation of the first-trimester cervix: a comparison between Lamicel and 16,16-dimethyl-trans delta 2 prostaglandin E1 methyl ester pessaries.
Both Lamicel and 16,16-dimethyl-trans delta 2 prostaglandin (PG) E1 methyl ester pessaries have recently been shown to be effective for cervical dilatation prior to first-trimester abortion. In the study described, the force required to dilate the cervix prior to vaginal termination of pregnancy was measured in three groups of patients--a control group, a group which received Lamicel , and a group which received 16,16-dimethyl-trans delta 2 PGE1 methyl ester pessaries. The total force required to dilate the cervix to 10 mm was significantly reduced in the treated groups, but there was no significant difference between the two treatment regimens. The use of Lamicel is associated with fewer side effects.
D015064:16,16-Dimethylprostaglandin E2 / Q000009:adverse effects / Q000494:pharmacology*; D000022:Abortion, Spontaneous; D000293:Adolescent; D000328:Adult; D002584:Cervix Uteri / Q000187:drug effects*; D004106:Dilatation; D005260:Female; D006801:Humans; D008278:Magnesium Sulfate / Q000009:adverse effects / Q000494:pharmacology*; D010570:Pessaries; D011142:Polyvinyl Alcohol / Q000009:adverse effects / Q000494:pharmacology*; D011247:Pregnancy; D011292:Premedication; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*
C034860:Lamicel; D011459:Prostaglandins E, Synthetic; D008278:Magnesium Sulfate; D011142:Polyvinyl Alcohol; D015064:16,16-Dimethylprostaglandin E2