Alterations in levels of apolipoprotein C-III and C-II/C-III ratios in patients with liver disease.
Apolipoprotein (apo) C-III levels and relative proportions of apo C-II and apo C-III were determined in patients with liver disease in attempts to show the relationship between abnormalities in lipoprotein metabolism and liver function. The levels of apo C-III decreased in most patients with liver disease except cases with fatty liver or cholestasis. The levels of apo C-III correlated with some liver function parameters such as albumin but not with triglyceride concentrations. The C-II/C-III ratios were higher in patients with liver disease, a decrease in apo C-III-1 being most prominent. Estimation of the levels of apo C-II suggested that the C-II levels would not be impaired in most of patients with liver disease, despite a decrease in apo C-III levels.
D000328:Adult; D053304:Apolipoprotein C-II; D053305:Apolipoprotein C-III; D001053:Apolipoproteins / Q000097:blood*; D001056:Apolipoproteins C; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007122:Immunoelectrophoresis; D008075:Lipoproteins, HDL / Q000097:blood; D008099:Liver / Q000378:metabolism; D008107:Liver Diseases / Q000097:blood* / Q000378:metabolism; D008875:Middle Aged; D012709:Serum Albumin / Q000032:analysis; D014280:Triglycerides / Q000097:blood
D053304:Apolipoprotein C-II; D053305:Apolipoprotein C-III; D001053:Apolipoproteins; D001056:Apolipoproteins C; D008076:Cholesterol, HDL; D008075:Lipoproteins, HDL; D012709:Serum Albumin; D014280:Triglycerides; D002784:Cholesterol