Parotid gland atrophy induced by occlusion of the ductal system with a protein solution.
Nonneoplastic disorders of the parotid gland, such as chronic recurrent parotitis, asymptomatic gland enlargement, or salivary fistulae, are therapeutic problems. Surgical removal of the gland is often difficult, since scar tissue may be present in these benign diseases. Therefore, alternative treatment methods, such as ligation of Stensen's duct, irradiation, or tympanic neurectomy, have been used to induce atrophy of gland parenchyma. This goal can also be attained by intraluminal duct occlusion, which involves instillation of a resorbable protein solution into the duct system, a procedure similar to sialographic injection. Intraluminal duct occlusion is a simple technique with rapid onset of atrophy and low morbidity, and with its use options remain open for other treatment modalities. The authors have used this method in the treatment of various diseases in 26 parotid glands and one submandibular gland. Their experience, which includes three-year patient follow-up data, suggests that this technique may be a useful alternative to salivary gland resection in certain nonneoplastic diseases.
D000328:Adult; D001284:Atrophy; D002908:Chronic Disease; D005260:Female; D006801:Humans; D010305:Parotid Diseases / Q000473:pathology / Q000628:therapy*; D010306:Parotid Gland / Q000187:drug effects / Q000473:pathology*; D010309:Parotitis / Q000473:pathology; D011506:Proteins / Q000494:pharmacology / Q000627:therapeutic use*; D012793:Sialadenitis / Q000628:therapy; D012996:Solutions
D011506:Proteins; D012996:Solutions