title: Exercise-induced asthma. Physiologic and clinical considerations.
abstract: This article discusses the physiologic and clinical aspects of exercise-induced asthma. Alterations in heat and water exchange in the respiratory tract appear to be important in initiating exercise-induced asthma, which can be reproduced by isocapneic hyperventilation with cold dry air. These pulmonary responses are also closely related to the level of non-specific airways hyperreactivity. Proposed mechanisms by which airways cooling and drying produce bronchospasm are reviewed and therapeutic approaches are discussed.
mesh_terms: D000707:Anaphylaxis / Q000209:etiology; D001249:Asthma / Q000503:physiopathology*; D001250:Asthma, Exercise-Induced / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D001833:Body Temperature Regulation; D001980:Bronchi / Q000294:innervation; D001985:Bronchial Provocation Tests; D001986:Bronchial Spasm / Q000503:physiopathology; D003080:Cold Temperature; D005080:Exercise Test; D006801:Humans; D006985:Hyperventilation / Q000503:physiopathology; D009420:Nervous System / Q000503:physiopathology; D005082:Physical Exertion; D012129:Respiratory Function Tests