[Effect of somatotropin on cathepsin D in the liver of hypo- and hyperthyroid rats].
In experiments on albino male rats the dependence of the cathepsin D activity on the thyroid hormone- and somatotropin levels in the organism was studied. It was demonstrated that the total cathepsin D activity in the liver of hypothyroid rats is lowered by 37% and that of hyperthyroid animals is augmented by 63%. Somatotropin injected to intact rats within 10 days in doses of 0.5 mg/100 g body weight enhanced the total enzyme activity by 19%. Hormone injection to hypothyroid animals returns to the normal cathepsin D activity, whereas in hyperthyroid rats the enzyme effect is significantly lowered under hormone action. Protein content in the nucleus-free homogenate of the hypothyroid rat liver does not differ from that of intact rats and is increased by 27% in hyperthyroid animals. Exogenous somatotropin returns to normal protein content in hyperthyroid rats.
D000818:Animals; D002402:Cathepsin D; D002403:Cathepsins / Q000378:metabolism*; D004353:Drug Evaluation, Preclinical; D013006:Growth Hormone / Q000627:therapeutic use*; D007037:Hypothyroidism / Q000188:drug therapy* / Q000201:enzymology; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013965:Thyroidectomy; D013997:Time Factors
D013006:Growth Hormone; D002403:Cathepsins; D002402:Cathepsin D
Vliianie somatotropina na aktivnost' katepsina D, v pecheni gipo- i gipertireoidnykh krys.