title: Treatment of experimental visceral leishmaniasis with lymphokine encapsulated in liposomes.
abstract: Highly susceptible mice were infected with Leishmania donovani chagasi and were treated with supernatants, free or encapsulated in liposomes, from concanavalin A-stimulated or unstimulated mouse spleen cell cultures. Treatment consisted of multiple i.v. injections beginning 2 days before to 2 days after infection. Mice treated with lymphokine-rich supernatants encapsulated in liposomes had significantly fewer liver parasites than the control groups, demonstrating in vivo activity of lymphokine against an infectious organism.
mesh_terms: D000818:Animals; D003208:Concanavalin A / Q000627:therapeutic use; D007167:Immunotherapy; D007891:Leishmania / Q000254:growth & development / Q000276:immunology; D007898:Leishmaniasis, Visceral / Q000276:immunology / Q000469:parasitology / Q000628:therapy*; D008081:Liposomes / Q000008:administration & dosage*; D008109:Liver Diseases, Parasitic / Q000628:therapy; D008222:Lymphokines / Q000627:therapeutic use*; D008264:Macrophages / Q000276:immunology / Q000469:parasitology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000276:immunology
chemical_list: D008081:Liposomes; D008222:Lymphokines; C021649:concanavalin A-induced helper factors; D003208:Concanavalin A