[Retroaldol cleavage of the glyopeptide antibiotic ristomycin A during alkaline inactivation].
The chemical and physicochemical characteristics of one of the two inactive components, i.e. the reduced product of alkaline inactivation (PAH-II) of ristomycin. A were studied. The components formed on the antibiotic incubation in mild alkaline media: 0.05 M NaOH, 37 degrees C, 1.5-2 hours. It was shown that the retroaldol cleavage of the C alpha-C beta bond of the phenol serine fragment of the trinuclear dideschlorvancomycinic acid G at the aglycone N-end was one of the causes of ristomycin A rapid inactivation under such conditions.
D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004590:Electrophoresis, Paper; D006863:Hydrogen-Ion Concentration; D012310:Ristocetin / Q000032:analysis / Q000037:antagonists & inhibitors*; D012972:Sodium Hydroxide / Q000494:pharmacology; D012996:Solutions; D013056:Spectrophotometry, Ultraviolet; D013997:Time Factors
D012996:Solutions; D012310:Ristocetin; C016719:ristocetin A; D012972:Sodium Hydroxide
O retroal'dol'nom rasshcheplenii antibiotika-glikopeptida ristomitsina A v khode shchelochnoĭ inaktivatsii.