Physicochemical and metabolic properties of modified metallothioneins.
Attempts to crosslink metallothionein through lysine residues have resulted in trapping of octameric structures. Two such polymers have been characterized. They are of a critical size for glomerular filtration, and unique tissue distributions of cadmium arise when they are injected into rats.
D000818:Animals; D002104:Cadmium / Q000378:metabolism; D008297:Male; D008668:Metallothionein / Q000378:metabolism*; D008970:Molecular Weight; D011108:Polymers / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D011108:Polymers; D002104:Cadmium; D008668:Metallothionein