title: [The concept of protein profile].
abstract: From their own experience of the simultaneous immunonephelometry of eight serum proteins, the authors propose a definition of protein profile from the point of view both of laboratory technique and interpretation. The assay should be performed quickly and the results expressed diagrammatically in normalised values, in such a way that the relative variation in protein levels can be easily visualised. A protein profile should thus comprise a minimum of proteins to be measured, chosen according to protein physiopathology and the type of abnormality under investigation. Interpretation is based on inter-protein correlations that may appear or disappear depending on the underlying physiopathology. This makes it possible to study inter-protein variation and thus avoid the probabilistic "interpretation" of single proteins taken in isolation. From this approach syndromes can be divided into two groups, elementary or complex. The authors provide examples of each, and propose an interpretation model based on this dichotomy.
mesh_terms: D001797:Blood Protein Electrophoresis; D001798:Blood Proteins / Q000032:analysis* / Q000502:physiology; D004588:Electrophoresis, Cellulose Acetate; D005921:Glomerulonephritis / Q000097:blood; D006461:Hemolysis; D006801:Humans; D007120:Immunochemistry; D007249:Inflammation / Q000097:blood* / Q000503:physiopathology; D000090463:Iron Deficiencies; D008107:Liver Diseases / Q000097:blood; D009391:Nephelometry and Turbidimetry / Q000379:methods
chemical_list: D001798:Blood Proteins
vernacular_title: Le concept du profil protéique.