Methylphenidate increases heart rate, blood pressure and plasma epinephrine in normal subjects.
Following an intravenous infusion of methylphenidate (0.3 mg/kg) there were significant increases in plasma epinephrine, heart rate, systolic and diastolic pressure, but there was no change in plasma norepinephrine. This pattern of response differs from that seen with D-amphetamine or caffeine.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects*; D004837:Epinephrine / Q000097:blood*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology*; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood; D013997:Time Factors
D008774:Methylphenidate; D009638:Norepinephrine; D004837:Epinephrine