title: Glycosphingolipids of chicken skeletal muscle in early development and genetic dystrophy.
abstract: The acidic and neutral GSL of chicken pectoral muscle and the activities of relevant sialyltransferase and glycosidases have been examined during embryonic and early post-hatching development. At this stage of myogenesis, a prominent shift to the neutral GSL of longer oligosaccharide length involving Forssman glycolipid most prominently and also globoside and GbOse3Cer occurred but the distribution of muscle-type gangliosides was not obviously affected. The glycosidase and sialyltransferase activities decreased dramatically just prior to or at hatching. The fusion-linked change in GSL suggests a role for terminal galactosamine and/or galactose residues in myoblast aggregation. A parallel developmental study of genetic muscular dystrophy revealed similar GSL levels and enzyme activities. A larger proportion of lactosylceramide in dystrophic muscle throughout development suggests a developmental lag in the mutant.
mesh_terms: D000375:Aging; D000818:Animals; D002642:Chick Embryo; D002645:Chickens; D006026:Glycoside Hydrolases / Q000378:metabolism; D006028:Glycosphingolipids / Q000378:metabolism*; D024510:Muscle Development; D009132:Muscles / Q000196:embryology / Q000201:enzymology; D009137:Muscular Dystrophy, Animal / Q000201:enzymology*; D012799:Sialyltransferases / Q000378:metabolism
chemical_list: D006028:Glycosphingolipids; D012799:Sialyltransferases; D006026:Glycoside Hydrolases