title: The effect of age on the nerve fiber population of the human optic nerve.
abstract: Nerve fiber counts of 16 normal human optic nerves from subjects aged 3.5 to 82 years showed a significant effect of age (P = .0207). The delay between death or enucleation and fixation also significantly affected the result (P = .0078). The mean (+/- S.E.M.) count for the 16 nerves was 1,244,005 +/- 20,033 fibers, giving a 99% confidence level between 1,192,400 and 1,295,610 fibers.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D001369:Axons; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D005902:Glaucoma, Open-Angle / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D009412:Nerve Fibers; D009900:Optic Nerve / Q000473:pathology / Q000502:physiology*