Hypotensive actions of some analogues of platelet-activating factor (PAF) with higher potencies than natural PAF.
Substituents on the nitrogen atom of the phosphorylcholine moiety of natural C16 platelet-activating factor (PAF) were modified or replaced by more bulky groups, and their hypotensive activities were examined with rats. As a result, it was found that N-methylpiperidine and N-methylpyrrolidine analogues were 3-10 times more potent than natural C16-PAF.
D000818:Animals; D000959:Antihypertensive Agents; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D008297:Male; D010713:Phosphatidylcholines / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000959:Antihypertensive Agents; D010713:Phosphatidylcholines; D010972:Platelet Activating Factor