[Liver-protective effect of tocopherol acetate and selenium-containing preparations in tetracycline antibiotic lesions of the liver].
It was shown on 99 male albino rats that vitamin E, sodium selenite and Astragalus. L. infusion used separately lowered the toxic effect of tetracycline on the liver, while the use of vitamin E in combination with sodium selenite or Astragalus L. infusion prevented such an effect of the antibiotic. This was evident from the decreased levels of lipid peroxidation products, i.e. diene conjugates and malonic dialdehyde in the blood and liver, and a simultaneous increase in the ratio of sulfhydryl and disulfide groups in these biosubstrates. Parallelism of the changes in these indices of the blood and liver was observed. It is suggested that lipid peroxidation plays an important part in the pathogenesis of liver affection with tetracyclines. The combined use of vitamin E and selenium-containing drugs is considered advisable for the prophylaxis and treatment of such affections.
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury / Q000188:drug therapy* / Q000378:metabolism; D002751:Chlortetracycline / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D010936:Plant Extracts / Q000627:therapeutic use*; D051381:Rats; D020887:Selenious Acid; D012643:Selenium / Q000627:therapeutic use*; D013752:Tetracycline / Q000633:toxicity*; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D008054:Lipid Peroxides; D010936:Plant Extracts; D014810:Vitamin E; D020887:Selenious Acid; D013752:Tetracycline; D024502:alpha-Tocopherol; D012643:Selenium; D024505:Tocopherols; D002751:Chlortetracycline
Gepatozashchitnyĭ éffekt tokoferola atsetata i selensoderzhashchikh preparatov pri porazhenii pecheni tetratsiklinovymi antibiotikami.