Behavioural effects of beta,beta'-iminodipropionitrile (IDPN) in the domestic fowl (Gallus domesticus).
The behavioural effects of beta,beta'-iminodipropionitrile (IDPN) were studied in chicks and adult fowls. Repeated administration of IDPN (75 mg/kg) for 5 days induced behavioural changes in chicks and adult fowls characterized by excitation, choreiform head and neck movements and circling (ECC-syndrome). Both acute and chronic administration of IDPN induced EEG desynchronization, EMG activation and enhancement of photic-evoked response (PER) in the hyperstriatum and pontine reticular formation while a decrease in PER was observed in the optic tectum. d-Amphetamine (2.5-5 mg/kg), apomorphine (0.1-0.25 mg/kg), piribedil (2.5-5 mg/kg), atropine (2.5-5 mg/kg), hyoscine (2.5-5 mg/kg) and cyproheptadine (0.5 mg/kg) potentiated the circling and choreiform head and neck movements. These activities were antagonized by pimozide (1 mg/kg), physostigmine (0.5 mg/kg) and quipazine (2.5-5 mg/kg). The results suggest that dopaminergic, serotoninergic and cholinergic mechanisms may be involved in IDPN-induced behavioural effects in chicks.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004569:Electroencephalography; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009570:Nitriles / Q000494:pharmacology*; D011200:Poultry / Q000502:physiology*; D013577:Syndrome
D009570:Nitriles; C008110:3,3'-iminodipropionitrile