Cell-substrate interaction. A method for evaluating the possible correlation between metastatic phenotype and cell surface energy.
The interfacial energy of the non-attached to substrate cell surface was analysed in tumor cell variants of the K-1735 melanoma and UV-2237 fibrosarcoma series, which exhibit distinct metastatic phenotypes. The highly metastatic cell variants exhibited a two-fold increase in the ability to form rapid cell substrate interactions, as compared with their low-metastatic counterparts. These results further highlight the possible role of cell adhesiveness in the process of metastasis.
D000818:Animals; D002448:Cell Adhesion; D002460:Cell Line; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology; D008545:Melanoma / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D009362:Neoplasm Metastasis; D013499:Surface Properties