title: Transfer of tetracycline or clindamycin resistance among strains of Bacteroides fragilis in experimental abscesses.
abstract: The ability of strains of Bacteroides fragilis resistant to clindamycin and/or tetracycline to transfer resistance to a susceptible recipient strain in experimental subcutaneous abscesses in mice was investigated. The results indicated that such transfer took place at a frequency similar to that observed in vitro. Transfer of resistance determinants at infected sites may play a role in the epidemiology of disseminated resistance to antimicrobial agents.
mesh_terms: D000038:Abscess / Q000382:microbiology*; D000667:Ampicillin / Q000494:pharmacology; D000818:Animals; D001442:Bacteroides Infections / Q000382:microbiology*; D001441:Bacteroides fragilis / Q000187:drug effects* / Q000235:genetics; D002981:Clindamycin / Q000494:pharmacology*; D003227:Conjugation, Genetic; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011815:R Factors; D013752:Tetracycline / Q000494:pharmacology*
chemical_list: D002981:Clindamycin; D000667:Ampicillin; D013752:Tetracycline