Histamine H2-binding studies in the guinea-pig brain.
Using 3H-mepyramine and 3H-tiotidine to label, respectively, the histamine H1- and H2-receptors, we have assessed the distribution of these receptors in five distinct areas of guinea-pig brain. With regard to the H2-receptor, we could detect no binding in either the cerebellum or pons-medulla, whereas the distribution in the other brain areas was corpus striatum greater than cortex greater than hippocampus. This was in contrast to the distribution of the H1-receptor which was found to be in all areas studied but predominantly in the cerebellum.
D000818:Animals; D001923:Brain Chemistry; D002927:Cimetidine / Q000031:analogs & derivatives / Q000378:metabolism; D005260:Female; D006168:Guinea Pigs; D008297:Male; D011738:Pyrilamine / Q000378:metabolism; D011869:Radioligand Assay; D011968:Receptors, Histamine / Q000032:analysis*; D011970:Receptors, Histamine H2 / Q000032:analysis*; D014316:Tritium
D011968:Receptors, Histamine; D011970:Receptors, Histamine H2; D014316:Tritium; D002927:Cimetidine; C023990:tiotidine; D011738:Pyrilamine