title: Local anesthetic effects of cocaine and several extracts of the coca leaf (E. coca).
abstract: Cocaine and a number of different fractions of a crude ethanol extract of the coca leaf (E. coca) were subjected to a local anesthetic screen using rat tail withdrawal from electric shock. Following an intradermal injection of 0.1 ml of a 2.0% (w.v) solution of cocaine HCl, an immediate response was observed. Two of the coca fractions also produced some local anesthesia. An alkaloidal fraction, containing an equivalent amount of cocaine, produced a maximum effect that was approximately 20% less than that observed with cocaine. The only other fraction producing any effect, a water soluble cocaine-free fraction, showed a maximum response that was approximately 30% of that observed with cocaine.
mesh_terms: D000779:Anesthetics, Local; D000818:Animals; D002849:Chromatography, Gas; D003041:Coca; D003042:Cocaine; D004597:Electroshock; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000779:Anesthetics, Local; D010936:Plant Extracts; D003042:Cocaine