title: [Clonal analysis of the intercellular variability in the functioning of human chromosomal nucleolus organizer regions].
abstract: Intercellular variability of NOR activity detected with the aid of Ag-staining of human chromosomes was studied in mass and cloned fibroblast cultures obtained from 3 individuals. The intercellular variability was determined by different staining of one of 10 NORs. According to this trait the heterogeneity of the cell population was discovered in all cloned lines, with this heterogeneity being the same as in the parent cultures. That concerned the number of a variable chromosome and the percentage of the cells with Ag-stained and unstained chromosomes. It is suggested that genetic determination in the progenies of the somatic cells concerns the whole spectrum of potential variability observed in cell populations.
mesh_terms: D000328:Adult; D002871:Chromosome Banding / Q000379:methods; D002877:Chromosomes, Human / Q000648:ultrastructure*; D002999:Clone Cells / Q000648:ultrastructure; D005347:Fibroblasts / Q000648:ultrastructure; D014644:Genetic Variation; D006801:Humans; D009697:Nucleolus Organizer Region / Q000648:ultrastructure*; D012867:Skin / Q000196:embryology / Q000648:ultrastructure
vernacular_title: Klonal'nyĭ analiz mezhkletochnoĭ variabel'nosti funktsionirovaniia iadryshkoobrazuiushchikh raĭonov khromosom cheloveka.