Prediction of the outcome of rhesus haemolytic disease of the newborn: additional information using an ADCC assay.
An in vitro test system is described which measures the ability of anti-D sera to lyse Rh(D)-positive red cells. This test was applied to anti-D sera from 11 cases of HDN selected in Glasgow and tested 'blind' in Edinburgh. Evidence is presented to support the view that the ADCC (antibody-dependent cell-mediated cytotoxicity ) assay can correctly identify those cases where there is a satisfactory clinical outcome despite a high level of anti-D suggesting otherwise. Amniocentesis might therefore be avoided in this group.
D000649:Amniocentesis; D000920:Antibody-Dependent Cell Cytotoxicity; D003601:Cytotoxicity Tests, Immunologic; D003951:Diagnostic Errors; D004899:Erythroblastosis, Fetal / Q000175:diagnosis* / Q000276:immunology; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000032:analysis; D011247:Pregnancy; D011296:Prenatal Diagnosis
D007518:Isoantibodies; C033242:RH-antibodies