Serotonin involvement in the inhibition of luteinizing hormone (LH) release during immobilization in castrated male rats.
The involvement of serotonin in mediating the inhibitory effect of immobilization stress on LH secretion in castrated male rats was examined by employing p-chlorophenylalanine (PCPA, 320 mg/kg, ip), an inhibitor of serotonin synthesis, and 5,6-dihydroxytryptamine (5,6-DHT, 50 micrograms, icv), a drug toxic to the indoleaminergic system. Immobilization stress suppressed pulsatile LH release and decreased mean plasma LH levels. Pretreatment with PCPA or 5,6-DHT apparently eliminated the inhibitory effect of immobilization stress on LH release. These results suggest the possible involvement of a serotoninergic mechanism in mediating the suppression of LH release induced by immobilization stress in castrated male rats.
D000818:Animals; D002369:Castration; D006801:Humans; D007103:Immobilization; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology*; D013997:Time Factors
D012701:Serotonin; D007986:Luteinizing Hormone