title: Neurologic deficit and cerebral ATP depletion after temporary focal ischemia in cats.
abstract: Focal ischemia was induced in 23 cats by occluding the left middle cerebral artery for 2 h. The animals were then divided into groups for unforced reperfusion of variable duration ranging from 2 to 48 h. Neurological ratings were obtained during both ischemia and reperfusion. Following planned sacrifice the regional ATP content was assessed by means of a bioluminescence method showing spatial distribution and degree of ATP depletion. All the animals developed a neurologic deficit, with a median of 6 points on a disability scale of 0-10. After reopening of the middle cerebral artery, neurologic recovery was quite variable depending on the initial neurologic deficit (partial phi = 0.67, p1 less than 0.05): Animals with mild initial functional impairment improved and those with severe neurologic disturbances either died early or developed a more severe neurologic deficit, irrespective of the duration of reperfusion. The degree of ATP depletion and the amount of brain tissue involved exhibited a significant correlation with the neurological outcome (tau = 0.50, p1 less than 0.05), but they were even more closely related to the initial neurologic deficit (partial phi = 1.00, p1 less than 0.001), suggesting an early definitive manifestation of deficiencies in regional energy metabolism.
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism*; D000818:Animals; D002545:Brain Ischemia / Q000378:metabolism* / Q000503:physiopathology; D002415:Cats; D002536:Cerebral Arteries / Q000378:metabolism / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D005260:Female; D008297:Male
chemical_list: D000255:Adenosine Triphosphate