title: Plasma concentration, mammary excretion and side-effects of phenylbutazone after repeated oral administration in healthy cows.
abstract: Seven clinically healthy dairy cows were each given 2.5 g phenylbutazone (approximately 5 mg/kg body weight) by oral administration twice daily for 8 days. The concentrations of phenylbutazone in plasma and milk and several blood parameters were studied. The minimum plasma concentration during steady state was 100.4 +/- 7.3 micrograms/ml. During the same period the milk concentration never exceeded 1% of the plasma concentration. The elimination half-life in plasma was 38.6 +/- 3.7 h. Five days after administration had been discontinued, the milk concentration was 0.05 +/- 0.01 microgram/ml. All seven cows were clinically healthy throughout the experiment. The most pronounced side-effect of the blood parameters studied was a decreased concentration of leucocytes to about two-thirds of the control value. This might have a pronounced influence on the effectiveness of the immune system. There was also a significant decrease in total bilirubin indicating a decrease in the breakdown of erythrocytes.
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D002417:Cattle; D005260:Female; D006207:Half-Life; D007700:Kinetics; D007774:Lactation / Q000187:drug effects; D008892:Milk / Q000378:metabolism*; D010653:Phenylbutazone / Q000009:adverse effects / Q000097:blood / Q000378:metabolism*; D011247:Pregnancy; D011485:Protein Binding
chemical_list: D001798:Blood Proteins; D010653:Phenylbutazone