Schistosoma mansoni: relationship between turnover rates of membrane proteins and susceptibility to immune damage of schistosomula.
Both dialysed fetal calf serum (DFCS) and concanavalin A (Con A) are known to decrease the susceptibility of schistosomulum of Schistosoma mansoni to damage by antibody and complement in vitro. The effects of DFCS and Con A on the synthesis and turnover rate of individual proteins in the surface membranes have been measured. DFCS increases the synthesis and turnover rate of low molecular weight proteins while Con A decreases the synthesis and turnover rate of high molecular weight proteins. It is suggested that DFCS and Con A act by different mechanisms to alter the properties of the surface membrane and that in vivo both mechanisms operate to protect the membrane against immune damage.
D000818:Animals; D000906:Antibodies; D002462:Cell Membrane / Q000276:immunology; D003165:Complement System Proteins; D003208:Concanavalin A / Q000494:pharmacology; D008565:Membrane Proteins / Q000276:immunology / Q000378:metabolism*; D012550:Schistosoma mansoni / Q000276:immunology / Q000378:metabolism*
D000906:Antibodies; D008565:Membrane Proteins; D003208:Concanavalin A; D003165:Complement System Proteins