[2,5-diaryl-substituted 1,3,4-oxadiazoles: synthesis and preliminary pharmacological investigation].
Seven 2,5-diarylalkyloxysubstituted 1,3,4-oxadiazoles were synthesized. They showed pronounced antiphlogistic action together with central activity (sedative, analgesic) that principally seems to be connected with the presence in the molecule of the 3,4-dioxymethylenephenyl radical.
D000700:Analgesics / Q000138:chemical synthesis; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D000927:Anticonvulsants / Q000138:chemical synthesis; D001463:Barbiturates / Q000494:pharmacology; D004357:Drug Synergism; D006993:Hypnotics and Sedatives / Q000138:chemical synthesis; D008297:Male; D051379:Mice; D010069:Oxadiazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000700:Analgesics; D000893:Anti-Inflammatory Agents; D000927:Anticonvulsants; D001463:Barbiturates; D006993:Hypnotics and Sedatives; D010069:Oxadiazoles
1,3,4-ossadiazoli 2,5-diarilsostituiti: sintesi e ricerca farmacologica preliminare.