Urinary excretion of N-nitrosodimethylamine in rats after Thalamonal narcosis.
Urinary excretion of N-nitrosodimethylamine (NDMA) in Sprague--Dawley rats was investigated after oral administration and inhalation of NDMA and concomitant narcosis by Thalamonal and diethyl ether. While ether anesthesia induced a 4-fold increase in the excretion rate, there was a drastic reduction (about 20-fold) in the amount of NDMA excreted after narcosis by Thalamonal.
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D004128:Dimethylnitrosamine / Q000652:urine*; D004329:Droperidol / Q000494:pharmacology*; D004338:Drug Combinations / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D005283:Fentanyl / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000777:Anesthetics; D004338:Drug Combinations; C001451:Innovar; D004128:Dimethylnitrosamine; D004329:Droperidol; D005283:Fentanyl