Repression of cytidine triphosphate synthetase in Salmonella typhimurium by pyrimidines during uridine nucleotide depletion.
Regulation of the synthesis of cytidine triphosphate (CTP) synthetase (EC 6.3.4.2) was investigated in Salmonella typhimurium. CTP synthetase appeared to be repressed only when intracellular concentrations of uridine nucleotides were significantly lowered. Under such nucleotide pool conditions, a cytidine compound and, to a lesser degree, a thymidine compound appeared as putative repressing metabolites of enzyme synthesis.
D019731:Carbon-Nitrogen Ligases; D003562:Cytidine / Q000494:pharmacology; D003570:Cytidine Triphosphate / Q000494:pharmacology; D004794:Enzyme Repression / Q000187:drug effects; D008025:Ligases / Q000096:biosynthesis*; D012486:Salmonella typhimurium / Q000201:enzymology*; D013936:Thymidine / Q000494:pharmacology; D014498:Uracil / Q000494:pharmacology
D014498:Uracil; D003562:Cytidine; D003570:Cytidine Triphosphate; D008025:Ligases; D019731:Carbon-Nitrogen Ligases; C019951:CTP synthetase; D013936:Thymidine