title: Association of metal tolerance with multiple antibiotic resistance of bacteria isolated from drinking water.
abstract: Bacterial isolates from the drinking water system of an Oregon coastal community were examined to assess the association of metal tolerance with multiple antibiotic resistance. Positive correlations between tolerance to high levels of Cu2+, Pb2+, and Zn2+ and multiple antibiotic resistance were noted among bacteria from distribution waters but not among bacteria from raw waters. Tolerances to higher levels of Al3+ and Sn2+ were demonstrated more often by raw water isolates which were not typically multiple antibiotic resistant. A similar incidence of tolerance to Cd2+ was demonstrated by isolates of both water types and was not associated with multiple antibiotic resistance. These results suggest that simultaneous selection phenomena occurred in distribution water for bacteria which exhibited unique patterns of tolerance to Cu2+, Pb2+, and Zn2+ and antibiotic resistance.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D003300:Copper / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D007854:Lead / Q000494:pharmacology; D008670:Metals / Q000494:pharmacology*; D009922:Oregon; D014871:Water Microbiology; D014881:Water Supply; D015032:Zinc / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D008670:Metals; D007854:Lead; D003300:Copper; D015032:Zinc