A new model of glucocorticoid-induced metanephric maldevelopment.
A new experimental model of glucocorticoid-induced tubular cyst formation has been developed in metanephric organ culture. The addition of cortisol (1.4 X 10(-5) M) to chemically defined serum-free culture medium produces cystic changes during in vitro nephrogenesis . The model isolates the role of glucocorticoids in experimental cyst formation.
D000818:Animals; D005938:Glucocorticoids / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000196:embryology* / Q000473:pathology; D052177:Kidney Diseases, Cystic / Q000139:chemically induced*; D051379:Mice; D009924:Organ Culture Techniques
D005938:Glucocorticoids