The effect of metrizamide on regional brain glucose metabolism in the rat.
The X-ray contrast material metrizamide is structurally related to 2-deoxyglucose and inhibits brain glucose phosphorylation in vitro. In vivo, the present autoradiographic study with labeled 2-deoxyglucose revealed a global reduction of brain glucose phosphorylation after metrizamide administration in the cisterna magna of rats. The reduction averaged 18% of all regions.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002946:Cisterna Magna; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D008297:Male; D008793:Metrizamide / Q000008:administration & dosage / Q000494:pharmacology*; D010085:Oxidative Phosphorylation / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D003837:Deoxy Sugars; D003847:Deoxyglucose; D008793:Metrizamide