[Comparative study of the DNA content and cross-sectional area of the interphase nuclei of epithelial cells in stomach polyps and cancer (based on gastric biopsy data)].
Cytospectrophotometric measurement of DNA level of interphase nuclei versus their cross-reaction area was carried out in mucosal cells of the stomach. The material included gastric bioptates from healthy subjects and patients with single and multiple adenomatous polyps of the stomach as well as gastric cancer. Tumor cells, and to a lesser degree, those of multiple polyps exhibited certain changes in DNA content: histograms showed several peaks and variations in DNA level increased, the latter being unmatched by a rise in DNA content per nucleus. A correlation was established between DNA content and cross-reaction area of interphase nuclei. Therefore, both parameters may serve for diagnosis.
D000328:Adult; D000368:Aged; D001706:Biopsy; D002467:Cell Nucleus / Q000032:analysis / Q000648:ultrastructure*; D004273:DNA, Neoplasm / Q000032:analysis*; D004848:Epithelium / Q000032:analysis / Q000648:ultrastructure; D005260:Female; D005753:Gastric Mucosa / Q000032:analysis / Q000648:ultrastructure; D006651:Histocytochemistry; D006801:Humans; D007399:Interphase; D008297:Male; D008875:Middle Aged; D011127:Polyps / Q000032:analysis* / Q000648:ultrastructure; D013274:Stomach Neoplasms / Q000032:analysis* / Q000648:ultrastructure
D004273:DNA, Neoplasm
Sravnitel'noe izuchenie soderzhaniia DNK i ploshchadi secheniia interfaznykh iader épitelial'nykh kletok polipov i raka zheludka (po dannym gastrobiopsiĭ).