Phencyclidine-induced malignant hyperthermia causing submassive liver necrosis.
This report describes three male patients arrested for aggressive and combative behavior, characteristic of phencyclidine intoxication, in whom severe hyperthermia, respiratory failure, and coma developed. Two days after the malignant hyperthermic event, serum transaminase levels rose acutely to extremely high levels with concomitant elevations in bilirubin levels and a fall in prothrombin activity. Liver biopsy specimens in two patients showed marked perivenular necrosis and collapse. No specific treatment was directed at the phencyclidine intoxication. Two of the three patients survived. Submassive liver necrosis caused by malignant hyperthermia is an unusual complication of phencyclidine abuse.
D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D006501:Hepatic Encephalopathy / Q000139:chemically induced; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D008305:Malignant Hyperthermia / Q000209:etiology*; D009336:Necrosis; D010622:Phencyclidine / Q000506:poisoning*; D011605:Psychoses, Substance-Induced / Q000209:etiology; D012131:Respiratory Insufficiency / Q000139:chemically induced; D019966:Substance-Related Disorders
D010622:Phencyclidine