Red-cell auto-antibodies mimicking anti-Fyb specificity.
An antibody is described, produced by an Fy(a+b-) woman that at first reacted with her own cells, preferentially with Fy(b+) cells but not with Fy(a-b-) cells. Later, pure anti-Fyb specificity occurred. Elution and absorption studies revealed that the antibody recognized a determinant absent from Fy(a-b-) cells but present on Fy(a+b-) and Fy(a-b+) cells, much more strongly, however, on the latter, and that it was an autoantibody.
D000744:Anemia, Hemolytic, Autoimmune / Q000209:etiology; D000918:Antibody Specificity; D001323:Autoantibodies / Q000276:immunology*; D001789:Blood Group Antigens / Q000276:immunology*; D001788:Blood Grouping and Crossmatching; D003298:Coombs Test; D004375:Duffy Blood-Group System / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D065227:Transfusion Reaction
D001323:Autoantibodies; D001789:Blood Group Antigens; D004375:Duffy Blood-Group System