Cortisol and dexamethasone elimination during treatment with cimetidine.
In a randomised cross-over study of treatment for 7 days with cimetidine 600 mg twice daily and placebo, cimetidine had no effect on the pharmacokinetics of a single intravenous dose of dexamethasone sodium phosphate. Likewise the elimination characteristics of endogenous cortisol in the dexamethasone suppressed state were not affected by cimetidine.
D000328:Adult; D002927:Cimetidine / Q000494:pharmacology*; D003907:Dexamethasone / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007700:Kinetics; D008297:Male; D011897:Random Allocation
D003907:Dexamethasone; D002927:Cimetidine; D006854:Hydrocortisone