Rapid induction of carcinoma in situ in dog urinary bladder by sequential treatment with N-methyl-N'-nitrosourea and N-butyl-N-(4-hydroxybutyl)-nitrosamine.
A highly atypical intraepithelial proliferation, which was interpreted as carcinoma in situ, developed in the urinary bladder of 2 beagle dogs after repeated intravesical instillations of N-methyl-N'-nitrosourea followed by oral administration of N-butyl-N-(4-hydroxybutyl)nitrosamine. The latent period was 37 weeks. The technique may provide a useful model to study the natural history of bladder cancer, particularly carcinoma in situ.
D000818:Animals; D002085:Butylhydroxybutylnitrosamine / Q000008:administration & dosage*; D002278:Carcinoma in Situ / Q000139:chemically induced*; D004285:Dogs; D004334:Drug Administration Schedule; D005260:Female; D008770:Methylnitrosourea / Q000008:administration & dosage*; D009602:Nitrosamines / Q000008:administration & dosage*; D009607:Nitrosourea Compounds / Q000008:administration & dosage*; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000473:pathology
D009602:Nitrosamines; D009607:Nitrosourea Compounds; D002085:Butylhydroxybutylnitrosamine; D008770:Methylnitrosourea