GM1 ganglioside treatment facilitates behavioral recovery from bilateral brain damage.
Adult rats with bilateral lesions of the caudate nucleus were treated with GM1 ganglioside. Although animals injected with a control solution were severely impaired in their ability to learn a complex spatial task, those treated with ganglioside were able to learn spatial reversals.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001930:Brain Injuries / Q000188:drug therapy* / Q000523:psychology; D002421:Caudate Nucleus / Q000187:drug effects / Q000293:injuries; D005677:G(M1) Ganglioside / Q000494:pharmacology / Q000627:therapeutic use*; D005732:Gangliosides / Q000627:therapeutic use*; D006801:Humans; D007858:Learning / Q000187:drug effects; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D005732:Gangliosides; D005677:G(M1) Ganglioside