Catechol derivatives of 6-aminobenzocycloheptene: assessment of dopaminergic effects.
The title compounds were prepared as congeners of the dopaminergically potent 2-amino-5,6-dihydroxytetralin series ("A-5,6-DTN"). None of the variously nitrogen-substituted benzocycloheptenes demonstrated any dopamine-like effects in a variety of assays. The primary amine had alpha 1-adrenoceptor stimulant effects. This lack of dopaminergic effect parallels the inactivity found in 6-aminobenzocycloheptenes bearing no oxygen substitutents, those bearing a single phenolic group, and those bearing a resorcinol 1,3-diphenolic substitution pattern.
D000818:Animals; D001567:Benzocycloheptenes / Q000138:chemical synthesis* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D004285:Dogs; D006339:Heart Rate / Q000187:drug effects; D007668:Kidney / Q000098:blood supply; D011954:Receptors, Dopamine / Q000378:metabolism*; D012039:Regional Blood Flow / Q000187:drug effects; D013564:Sympathetic Nervous System / Q000187:drug effects
D001567:Benzocycloheptenes; D011954:Receptors, Dopamine; C041852:1,2-dihydroxy-6,7,8,9-tetrahydro-6-aminobenzocycloheptene; C041853:1,2-dihydroxy-6-(N-(2-methylethyl)amino)-6,7,8,9-tetrahydrobenzocycloheptene; C041854:1,2-dihydroxy-6-((N-dipropyl)amino)-6,7,8,9-tetrahydrobenzocycloheptene