Hb Okazaki [beta 93(F8) Cys----Arg], a new hemoglobin variant with increased oxygen affinity and instability.
A new abnormal hemoglobin, Hb Okazaki [beta 93(F9) Cys----Arg], with an amino acid substitution at the tyrosine pocket of the beta chain as well as at the alpha 2 beta 1 contact of the quaternary structure of molecule, was discovered in a Japanese man. This hemoglobin showed increased oxygen affinity and molecular instability.
D000595:Amino Acid Sequence; D006455:Hemoglobins, Abnormal / Q000378:metabolism*; D006801:Humans; D007526:Isoelectric Point; D010108:Oxyhemoglobins; D010446:Peptide Fragments / Q000032:analysis; D013329:Structure-Activity Relationship
D006455:Hemoglobins, Abnormal; D010108:Oxyhemoglobins; D010446:Peptide Fragments