Anti-inflammatory effects of praseodymium, gadolinium and ytterbium chlorides.
Anti-inflammatory effects of chloride salts of praseodymium, gadolinium and ytterbium were investigated, using various experimental inflammatory models in rats. The lanthanide salts administered by oral route showed no significant effect, but when injected intraperitoneally they significantly inhibited the carrageenin-induced oedema, proportional to their doses ranging from 15 to 75 mg/kg. They also reduced nystatin-induced oedema and vascular permeability response to histamine and serotonin. Pronounced inhibitory effect of lanthanide salts at the dose of 50 mg/kg, i.p., was observed in histamine- and serotonin-induced changes in vascular permeability. Repeated administration of lanthanide salts in the dose of 20 mg/kg for 13 d significantly inhibited arthritis development. The same dose of these salts for a 6-d period similarly reduced granuloma formation. However, praseodymium, gadolinium and ytterbium chlorides showed no significant difference among themselves and their anti-inflammatory effects were smaller than those from phenylbutazone.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001168:Arthritis / Q000188:drug therapy; D002199:Capillary Permeability / Q000187:drug effects; D002712:Chlorides / Q000494:pharmacology / Q000627:therapeutic use; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy* / Q000503:physiopathology; D005682:Gadolinium / Q000494:pharmacology / Q000627:therapeutic use*; D006099:Granuloma / Q000188:drug therapy; D006632:Histamine / Q000494:pharmacology; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology / Q000627:therapeutic use; D011221:Praseodymium / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000494:pharmacology; D015018:Ytterbium / Q000494:pharmacology / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D002712:Chlorides; D012701:Serotonin; D006632:Histamine; D005682:Gadolinium; D010653:Phenylbutazone; D015018:Ytterbium; D011221:Praseodymium; C038958:gadolinium chloride