Baroreceptor-mediated inhibition of A5 noradrenergic neurons.
Spinally-projecting A5 noradrenergic neurons were recorded in urethane-anesthetized rats. All A5 neurons sampled were inhibited by raising the mean arterial blood pressure (mBP) in the 110-160 mm Hg range. Similar elevations of mBP in baroreceptor-denervated rats were without effect. Clonidine inhibited A5 neurons and enhanced the inhibitory effect of increasing peripheral blood pressure.
D000818:Animals; D001794:Blood Pressure; D001931:Brain Mapping; D003000:Clonidine / Q000494:pharmacology; D008297:Male; D009433:Neural Inhibition; D009638:Norepinephrine / Q000502:physiology*; D011149:Pons / Q000187:drug effects / Q000502:physiology*; D011311:Pressoreceptors / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012154:Reticular Formation / Q000187:drug effects / Q000502:physiology*; D014666:Vasomotor System / Q000502:physiology
D003000:Clonidine; D009638:Norepinephrine