[Induction of mutations in mammalian cells by the action of live vaccinal strains of poliomyelitis virus].
The attenuated strains' poliomyelitis virus induces mutagenesis in human and Chinese hamster cultured cells. The mutagenic action of the poliovirus is detected at chromosome and gene levels and directly depends on the multiplicity of cell infection. Possibilities for developing nonmutagenic antivirus vaccines are discussed.
D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D005796:Genes / Q000187:drug effects; D006801:Humans; D008677:Metaphase / Q000187:drug effects; D009154:Mutation; D011054:Poliovirus Vaccine, Inactivated / Q000494:pharmacology; D011055:Poliovirus Vaccine, Oral / Q000494:pharmacology*; D013997:Time Factors
D011054:Poliovirus Vaccine, Inactivated; D011055:Poliovirus Vaccine, Oral
Induktsiia mutatsiĭ v kletkakh mlekopitaiushchikh pod deĭstviem zhivykh vaktsinal'nykh shtammov virusa poliomielita.