title: The frequency of serological anti-zona pellucida activity in males, females and children.
abstract: 945 human sera from children, fertile and infertile females, pregnant women and fertile and infertile males were tested for antibodies to porcine zona pellucida by immunofluorescence and the pronase-induced zona-lysis inhibition test. Positive sera were found in each of the groups examined, with a higher percentage of anti-zona activity in infertile, pregnant and menopausal women. There was no correlation between anti-sperm antibody titer and the incidence of anti-zona activity in either female or male human sera, nor did the occurrence of anti-zona activity correlate with a particular blood group type.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D007223:Infant; D007247:Infertility, Female / Q000276:immunology; D007248:Infertility, Male / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010063:Ovum / Q000276:immunology*; D011247:Pregnancy; D013094:Spermatozoa / Q000276:immunology; D013552:Swine; D015044:Zona Pellucida / Q000276:immunology*
chemical_list: D001323:Autoantibodies