Differential inhibition of LTD4-mediated bronchopulmonary effects by salbutamol.
The effects of systemically administered salbutamol on LTD4-induced changes in pulmonary mechanics and tracheal microvascular permeability in the anesthetized guinea pig were compared. Salbutamol (50 micrograms/kg i.v.) virtually abolished the decreases in Cdyn and Gaw produced by i.v. LTD4, but did not alter the LTD4-induced increase in tracheal microvascular permeability. Thus, it appears that although the spasmolytic properties of salbutamol may profoundly inhibit LTD4-mediated bronchoconstriction, salbutamol might only be of limited value in reducing the airway inflammatory effects of LTD4.
D000403:Airway Resistance / Q000187:drug effects; D000420:Albuterol / Q000494:pharmacology*; D000818:Animals; D001980:Bronchi / Q000187:drug effects*; D002199:Capillary Permeability / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D008170:Lung Compliance / Q000187:drug effects; D008297:Male; D013189:SRS-A / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D013189:SRS-A; D000420:Albuterol