Plasma vasopressin levels after I.C.V. infusion of histamine agonists in the conscious goat.
Histamine H1-agonists 2-pyridylethylamine (2-PEA) and 2-methylhistamine and H2-agonists 4-methylhistamine, dimaprit and impromidine were given i.c.v. to conscious goats and the release of arginine vasopressin (AVP) was measured. 2-PEA at very low doses (9 and 27 mumoles/animal, equivalent to H1-activity of about 0.5 and 1.5 mumoles histamine, resp.) significantly increased plasma AVP. The H2-agonists did not cause consistent changes in AVP even if their relative doses were higher. It is concluded that the vasopressin releasing effect of histamine is due to H1-receptor activation.
D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006041:Goats; D008761:Methylhistamines / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*; D011968:Receptors, Histamine / Q000187:drug effects*; D011969:Receptors, Histamine H1 / Q000187:drug effects*; D011970:Receptors, Histamine H2 / Q000187:drug effects*; D014667:Vasopressins / Q000097:blood*
D008761:Methylhistamines; D011725:Pyridines; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D011970:Receptors, Histamine H2; D014667:Vasopressins; D001127:Arginine Vasopressin; C006183:2-(2-aminoethyl)pyridine