title: Neuroleptic malignant syndrome complicated by disseminated intravascular coagulation.
abstract: The neuroleptic malignant syndrome (NMS), clinically manifested by hyperpyrexia, mental status changes, muscular rigidity, and autonomic dysfunction, is an idiosyncratic reaction to major neuroleptic pharmacologic agents. The reported causes of morbidity and mortality include respiratory insufficiency, cardiovascular collapse, arrhythmias, and renal failure. Coagulopathy does not seem to be a prominent component of the syndrome. We observed a case of NMS in which disseminated intravascular coagulation was a prominent feature.
mesh_terms: D000328:Adult; D001342:Autonomic Nervous System Diseases / Q000139:chemically induced*; D001480:Basal Ganglia Diseases / Q000139:chemically induced*; D004211:Disseminated Intravascular Coagulation / Q000139:chemically induced*; D006220:Haloperidol / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009127:Muscle Rigidity / Q000139:chemically induced; D012128:Respiratory Distress Syndrome / Q000139:chemically induced; D013577:Syndrome
chemical_list: D006220:Haloperidol