Prolonged storage of aminophylline suppositories. The impact on physical parameters and bioavailability.
Prolonged storage of aminophylline/cocoa butter suppositories at 30 degrees resulted in a marked decrease in bioavailability, after administration to a panel of human volunteers. Not more than 20% of the drug content was absorbed during the first 8 hours and the maximum plasma level was obtained 5-7 hours after administration. It was concluded that storage conditions should be considered well and storage instructions should be given to the patient.
D000628:Aminophylline / Q000097:blood*; D001682:Biological Availability; D004356:Drug Storage; D006801:Humans; D008297:Male; D013488:Suppositories; D013997:Time Factors
D013488:Suppositories; D000628:Aminophylline