title: Clastogenic effects of biosynthetic human growth hormone in Snell dwarf mice and CHO cells in vitro.
abstract: Treatment of Snell dwarf mice with high concentrations of human growth hormone from pituitaries as well as of bacterial origin, significantly increased the frequencies of chromosomal aberrations in bone-marrow cells, as measured by the micronucleus test. In vitro treatment of Chinese hamster ovary (CHO) cells with the two types of hormone likewise induced structural chromosomal aberrations.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D002467:Cell Nucleus / Q000187:drug effects; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006224:Cricetinae; D013006:Growth Hormone / Q000096:biosynthesis / Q000494:pharmacology*; D051379:Mice; D008817:Mice, Mutant Strains / Q000502:physiology; D009154:Mutation / Q000187:drug effects*
chemical_list: D013006:Growth Hormone