Covalent hydration: a possible mechanism for aza-arene carcinogenesis.
It is hypothesized that differences in the carcinogenicity of certain aza-arenes and their carbocyclic analogs may originate from the ability of the former to form covalent hydrates. The hypothesis is primarily based on a comparison of the carcinogenicity of several aza-arenes with that of corresponding carbocyclic compounds and of aromatic amines which are structurally related to the hydrated aza-arenes. Additional evidence is provided by the regiochemistry of cytochrome P-450 catalyzed oxidation of quinoline.
D000588:Amines / Q000633:toxicity; D001372:Aza Compounds / Q000378:metabolism / Q000633:toxicity*; D001711:Biotransformation; D002273:Carcinogens; D011083:Polycyclic Compounds / Q000633:toxicity; D013329:Structure-Activity Relationship; D014867:Water
D000588:Amines; D001372:Aza Compounds; D002273:Carcinogens; D011083:Polycyclic Compounds; D014867:Water