title: Vasopressin response to hyperosmotic stimulus: blood pressure effect in normal subjects and patients with impaired sympathetic system.
abstract: We have investigated the interaction of plasma vasopressin and plasma catecholamines in quadriplegic patients (with severed sympathetic tracts) and compared them to others with intact sympathetic system following I.V. administration of a hyperosmolar radiocontrast agent during a routine diagnostic pyelography. Baseline systolic and diastolic pressure as well as plasma norepinephrine were significantly lower in the quadriplegic subjects. At 5 minutes after administration of the hyperosmolar solution, systolic and diastolic pressure as well as plasma vasopressin rose in the quadriplegic subjects but not in normal subjects despite a significant and equal rise in serum osmolality occurring in both groups. These results demonstrate that an interaction between the two systems exists in humans: an intact sympathetic nervous system attenuates the vasopressin response to hyperosmolar stimuli and in its absence vasopressin may function as a pressor agent.
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002395:Catecholamines / Q000097:blood; D003287:Contrast Media / Q000494:pharmacology; D003971:Diastole / Q000187:drug effects; D003973:Diatrizoate / Q000494:pharmacology; D003974:Diatrizoate Meglumine / Q000494:pharmacology; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D011782:Quadriplegia / Q000503:physiopathology; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000503:physiopathology*; D013599:Systole / Q000187:drug effects; D014567:Urography; D014667:Vasopressins / Q000097:blood*
chemical_list: D002395:Catecholamines; D003287:Contrast Media; D004338:Drug Combinations; D014667:Vasopressins; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; C027278:urovision