The frequency and distribution of apoptosis induced by three non-carcinogenic agents in mouse colonic crypts.
The appearance of apoptotic cells has been used as an index of carcinogen-induced damage inflicted on the colonic epithelium. We report here that 3 potent biological toxins, colchicine, puromycin and diphtheria toxin which have not been shown to be carcinogenic cause a dose-related increase in apoptotic cells in the colonic epithelium of the mouse. The distribution of apoptosis along the crypt length is characteristic for each of the agents studied.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity; D002467:Cell Nucleus / Q000187:drug effects* / Q000473:pathology; D002470:Cell Survival / Q000187:drug effects*; D003078:Colchicine / Q000633:toxicity; D003106:Colon / Q000187:drug effects / Q000648:ultrastructure; D004167:Diphtheria Toxin / Q000633:toxicity; D004848:Epithelium / Q000187:drug effects / Q000648:ultrastructure; D005260:Female; D007413:Intestinal Mucosa / Q000187:drug effects / Q000648:ultrastructure; D051379:Mice; D008810:Mice, Inbred C57BL; D011691:Puromycin / Q000633:toxicity
D002273:Carcinogens; D004167:Diphtheria Toxin; D011691:Puromycin; D003078:Colchicine