Potentiating action of hexoprenaline on 14C-aminopyrine uptake by isolated rat parietal cells.
Hexoprenaline potentiated the 14C-aminopyrine uptake (a reliable index of H+ generation) of isolated rat gastric cells stimulated by 10(-6) -10(-4) mol/l carbachol, and inhibited that in response to 10(-4) mol/l histamine without and in the presence of propranolol. It is concluded that hexoprenaline acts as a partial agonist on parietal cell H2-receptors and that beta-adrenoceptor activation may functionally modulate gastric acid secretion.
D000632:Aminopyrine / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002217:Carbachol / Q000494:pharmacology; D004357:Drug Synergism; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006594:Hexoprenaline / Q000494:pharmacology*; D006632:Histamine / Q000494:pharmacology; D010627:Phenethylamines / Q000494:pharmacology*; D051381:Rats
D010627:Phenethylamines; D000632:Aminopyrine; D006632:Histamine; D002217:Carbachol; D006594:Hexoprenaline