title: Serotonin involvement in the inhibition of luteinizing hormone (LH) release during immobilization in castrated male rats.
abstract: The involvement of serotonin in mediating the inhibitory effect of immobilization stress on LH secretion in castrated male rats was examined by employing p-chlorophenylalanine (PCPA, 320 mg/kg, ip), an inhibitor of serotonin synthesis, and 5,6-dihydroxytryptamine (5,6-DHT, 50 micrograms, icv), a drug toxic to the indoleaminergic system. Immobilization stress suppressed pulsatile LH release and decreased mean plasma LH levels. Pretreatment with PCPA or 5,6-DHT apparently eliminated the inhibitory effect of immobilization stress on LH release. These results suggest the possible involvement of a serotoninergic mechanism in mediating the suppression of LH release induced by immobilization stress in castrated male rats.
mesh_terms: D000818:Animals; D002369:Castration; D006801:Humans; D007103:Immobilization; D007986:Luteinizing Hormone / Q000097:blood / Q000378:metabolism*; D008297:Male; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D012701:Serotonin / Q000502:physiology*; D013315:Stress, Psychological / Q000503:physiopathology*; D013997:Time Factors
chemical_list: D012701:Serotonin; D007986:Luteinizing Hormone