Phenytoin-isoniazid interaction: a kinetic approach to management.
A case of phenytoin-isoniazid drug interaction is reported. Pharmacokinetic evaluation was performed on the basis of two different phenytoin serum concentrations obtained on two different dosage regimens. Whereas Vmax was found to be in the normal range, the patient's Km was increased five-fold. The literature regarding this interaction is reviewed. This case illustrates the usefulness of pharmacokinetic methods in the management of phenytoin-isoniazid interaction.
D000368:Aged; D004347:Drug Interactions; D006801:Humans; D007538:Isoniazid / Q000009:adverse effects*; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D010672:Phenytoin / Q000097:blood*; D013997:Time Factors
D010672:Phenytoin; D007538:Isoniazid