title: Ectopic hamartomatous thymoma. A distinctive benign lesion of lower neck.
abstract: Five cases of a distinctive tumor located in the soft tissues of the lower neck in adults are described. The lesion is characterized microscopically by the presence of four components: cellular areas made up of spindle elements; epithelial islands composed of solid nests, trabeculae and cysts; mature adipose tissue; and lymphocytes, sometimes arranged in a Hassall's corpuscle-like fashion. Electron microscopy and immunostaining for keratin showed that the spindle cell component was of epithelial nature. These tumors were supraclavicular or suprasternal in location, and no local recurrence has developed in any case following local resection. We interpret these lesions as benign tumors arising on the basis of a developmental defect. We think that they are derived from the third branchial arch and that they are composed of abnormal thymic tissue.
mesh_terms: D000328:Adult; D005260:Female; D006222:Hamartoma / Q000145:classification / Q000196:embryology / Q000473:pathology* / Q000648:ultrastructure; D006258:Head and Neck Neoplasms / Q000145:classification / Q000196:embryology / Q000473:pathology* / Q000648:ultrastructure; D006801:Humans; D008297:Male; D008875:Middle Aged; D013945:Thymoma / Q000145:classification / Q000196:embryology / Q000473:pathology* / Q000648:ultrastructure