Liver as a tumor-cell-killing organ.
Lymphoma cells (Eb and ESb, the metastasizing variant) were injected via a mesenteric vein. 85% to 95% of these cells were trapped in the liver. Most of the Eb cells (81%) were destroyed within 18 hours, ESb cells prove to be more resistant: only 28% of these cells were destroyed within this time. 51-Chromium release assay (4 hours) revealed a similar sensitivity of these two tumor cell strains.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D005260:Female; D007694:Killer Cells, Natural / Q000276:immunology*; D008099:Liver / Q000276:immunology*; D008223:Lymphoma / Q000378:metabolism*; D051379:Mice; D008811:Mice, Inbred DBA; D009362:Neoplasm Metastasis; D051381:Rats; D011919:Rats, Inbred Strains