A serum inhibitor of neutrophil chemotaxis associated with hyperglobulinaemia E in a patient with lymphoma, and recurrent skin infection.
A patient with a strong serum inhibitor of neutrophil chemotaxis, a possible chemotactic factor inactivator and hyperimmunoglobulinaemia E is described. The patient had a persistent chronic dermatitis which appeared to develop following radiation of the central nervous system for an unclassified lymphoma. Other abnormalities included a general increase of serum immunoglobulins, impaired lymphocyte response to mitogens, and a high Epstein-Barr antibody titre. This case illustrates that an increased IgE level, previously reported in association with a cellular chemotactic defect, may coexist with serum inhibitors of neutrophil chemotaxis.
D000328:Adult; D002634:Chemotaxis, Leukocyte; D003872:Dermatitis / Q000209:etiology / Q000276:immunology*; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology*; D007073:Immunoglobulin E; D008222:Lymphokines / Q000097:blood*; D008223:Lymphoma / Q000532:radiotherapy; D009504:Neutrophils / Q000276:immunology; D011878:Radiotherapy / Q000009:adverse effects; D012008:Recurrence
D008222:Lymphokines; C034397:chemotactic inhibitory factor; D007073:Immunoglobulin E