[Use of polyacrylate dispersions for spray coating phenobarbital. 1: Production and in vitro study of microcapsules].
The production of microcapsules (model drug: phenobarbital) using aqueous polyacrylate dispersions by means of spray drying is described. The influence of the following factors on formation and quality of the microcapsules is discussed: particle size of the drug, composition of the polyacrylate, viscosity of the spray material and quantitative relation between the drug and the coating material. The morphology of the microcapsules is investigated by means of light and screen electronic microscopy. The liberation of the drug is evaluated. Mainly dry spheric microcapsules arise in a one-working step. Their properties are influenced by variation of the polyacrylate composition. The liberation of the drug decreases with decreasing drug concentration (80-20%) and in dependence of the polyacrylate dispersion for spray coating and the resulting film.
D000180:Acrylic Resins; D002214:Capsules; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D008855:Microscopy, Electron, Scanning; D010634:Phenobarbital / Q000008:administration & dosage*; D012995:Solubility; D013499:Surface Properties; D014783:Viscosity
D000180:Acrylic Resins; D002214:Capsules; C006903:carbopol 940; D010634:Phenobarbital
Uber den Einsatz von Polyacrylatdispersionen zur Sprühverkapselung von Phenobarbital. 1. Mitteilung: Zur Herstellung und in-vitro-Untersuchung der Mikrokapseln.