title: [14C]normacromerine fate in the rat.
abstract: The biological fate of [14C] normacromerine , a dimethoxylated phenethylamine derivative with putative hallucinogenic properties, was evaluated in male Sprague-Dawley rats at 100 mg/kg po. Urine was the primary elimination route accounting for 50% of administered carbon-14 after 24 h. Of this urine radioactivity, normacromerine comprised 30% at 8 h decreasing to nondetectable levels at 24h. Carbon-14 in feces represented less than 10% of the administered dose at 24 h, and 14CO2 expiration was not detected. Studies of normacromerine fate in comparison with previously studied phenethylamines may enhance evaluation of hallucinogenic potential of normacromerine .
mesh_terms: D000470:Alkaloids / Q000378:metabolism* / Q000652:urine; D000818:Animals; D005243:Feces / Q000032:analysis; D006213:Hallucinogens; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D000470:Alkaloids; D006213:Hallucinogens; C002751:normacromerine