Chemical protection against genetic effect of radiation in male mice.
A study was made of the protective effect of some radioprotective agents against dominant lethal mutations (DLM) in postspermatogonial stages and reciprocal translocations (RT) in spermatogonia induced by gamma-radiation. Among the radioprotective agents used, cystaphos, a combination of cystamine and 5-MOT and a mixture of 6 components proved to be most effective against DLM, and cystaphos, gammaphos and cystamine combined with 5-MOT proved effective against RT. The degree of radioprotective efficacy was relatively low. The efficacy of cystamine in protecting against RT was higher with exposure of gonocytes of 18.5-day embryos than spermatogonia of pubertal animals. The degree of the radioprotective effect varied depending on the stage of spermatogenesis, and, in all cases, it was lower than that observed in studies of protection against lethal effects of ionizing radiation.
D000818:Animals; D005260:Female; D005313:Fetal Death; D005799:Genes, Dominant / Q000187:drug effects / Q000528:radiation effects*; D005804:Genes, Lethal / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009154:Mutation; D011247:Pregnancy; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D013093:Spermatogonia / Q000187:drug effects / Q000528:radiation effects*; D013094:Spermatozoa / Q000528:radiation effects*; D014178:Translocation, Genetic / Q000187:drug effects / Q000528:radiation effects*
D011837:Radiation-Protective Agents