Blood pressure in rats: a comparison of a multifactorial experimental design to measurements in an outbred stock.
Systolic blood pressure was measured in males of 8 inbred strains and 1 outbred stock of rats 5 times over a period of 20 min on 5 consecutive days. The strain means ranged between 107.9 mmHg and 149.3 mmHg. The estimated variance between strains (V = 248.7 mmHg) was about 5 times higher than the variance within strains (V = 54.3 mmHg). The intraindividual variance within strains was relatively constant (V = 24.0-37.6 mmHg), while the interindividual variance varied to a great extent (V = 4.5-44.5 mmHg) from strain to strain. The outbred stock showed values of blood pressure and components of variance similar to those of a single inbred strain. Thus, by investigation of a battery of 8 inbred strains in a multifactorial experimental design a greater phenotypic variability due to genetic strain differences is achieved than by measurements in a single outbred stock.
D000704:Analysis of Variance; D000818:Animals; D001794:Blood Pressure; D001835:Body Weight; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains / Q000502:physiology*; D013045:Species Specificity; D013599:Systole