title: Pulmonary hypertension, pulmonary edema, and decreased pulmonary compliance produced by increased ICP in cats.
abstract: Cats, anesthetized with sodium pentobarbital, were cannulated to measure pulmonary, systemic, and left atrial pressures and pulmonary ventilation, compliance, and resistance. Intracranial pressure was elevated to 30 mm Hg by injecting silicone oil into the extradural space. After an average time of 56 minutes, pulmonary systolic and diastolic pressures more than doubled, systemic systolic pressure sometimes rose and sometimes fell, and diastolic pressure rose 5%. Left atrial pressure never exceeded 8 cm of saline. Pulmonary compliance decreased by one-half, but airway resistance was unchanged. Pulmonary edema was estimated from histological sections. The pulmonary hypertension may be the result of a sympathetic discharge confined to the lung, since no remarkable changes in heart rate or systemic blood pressure occurred. The decrease in pulmonary compliance followed the rise in pulmonary arterial pressure, and is interpreted as the result of interstitial edema. There was no evidence that left heart failure or elevated left atrial pressure caused the pulmonary edema.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002302:Cardiac Output; D002415:Cats; D002540:Cerebral Cortex / Q000473:pathology; D006339:Heart Rate; D006976:Hypertension, Pulmonary / Q000503:physiopathology*; D007427:Intracranial Pressure; D008170:Lung Compliance; D011654:Pulmonary Edema / Q000503:physiopathology*; D014655:Vascular Resistance