Is the induction of neuroblastoma differentiation by CCA mediated by its effects on the electrochemical gradient?
Various mitochondrial inhibitors are tested in neuroblastoma cells. Their effects on the mit-proteins and some cytoskeletal proteins are compared to those of CCA, a differentiation inducer. This comparison favours the hypothesis that the primary effect of CCA induction is an alteration of the electrochemical gradient.
D000199:Actins / Q000096:biosynthesis; D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects*; D002478:Cells, Cultured; D003509:Cyclohexanecarboxylic Acids / Q000494:pharmacology*; D007381:Intermediate Filament Proteins / Q000096:biosynthesis; D008564:Membrane Potentials / Q000187:drug effects; D051379:Mice; D008928:Mitochondria / Q000187:drug effects*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D009447:Neuroblastoma / Q000473:pathology; D014404:Tubulin / Q000096:biosynthesis; D014746:Vimentin
D000199:Actins; D003509:Cyclohexanecarboxylic Acids; D007381:Intermediate Filament Proteins; D009419:Nerve Tissue Proteins; D014404:Tubulin; D014746:Vimentin; C027655:1-methylcyclohexanecarboxylic acid