Disturbance of recent memory function in parkinsonian patients on anticholinergic therapy.
Disruption of cholinergic neurotransmission may result in memory impairment. In this study the anticholinergic drug, trihexyphenidyl, at low doses when administered chronically for one month to Parkinson disease patients caused a decrease in performance on recent but not immediate memory tests. Awareness of possible deterioration of memory function of parkinsonian patients on anticholinergic medication is necessary.
D000368:Aged; D006801:Humans; D008568:Memory / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects*; D010153:Paired-Associate Learning / Q000187:drug effects; D010300:Parkinson Disease / Q000188:drug therapy*; D014282:Trihexyphenidyl / Q000009:adverse effects* / Q000627:therapeutic use; D014706:Verbal Learning / Q000187:drug effects
D014282:Trihexyphenidyl