Inhibition of autophagy by benzyl alcohol.
Benzyl alcohol caused a rather complete and selective inhibition of the methylamine sensitive (i.e., the putative lysosomal) pathway of protein degradation in isolated rat hepatocytes. The effect was found to be entirely reversible within 30 min of removing the agent. A morphometric examination of electron micrographs revealed that the inhibition of lysosomal protein degradation coincided with a block in the formation of autophagic vacuoles. The number of acidic vacuoles (i.e., vacuoles induced to swell by adding methylamine) was not drastically reduced.
D000818:Animals; D001343:Autophagy / Q000187:drug effects*; D019905:Benzyl Alcohol; D001592:Benzyl Alcohols / Q000494:pharmacology*; D001593:Benzyl Compounds / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure; D008247:Lysosomes / Q000378:metabolism; D008297:Male; D008744:Methylamines / Q000494:pharmacology; D008854:Microscopy, Electron; D010587:Phagocytosis / Q000187:drug effects*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014633:Valine / Q000378:metabolism
D001592:Benzyl Alcohols; D001593:Benzyl Compounds; D008744:Methylamines; D011506:Proteins; C027451:methylamine; D014633:Valine; D019905:Benzyl Alcohol