The anti-chlamydial effect of experimental Mycoplasma pulmonis infection in the murine genital tract.
Experimental Chlamydia trachomatis infection of the genital tract of female CBA and TO mice was greatly curtailed by a concurrent genital infection with Mycoplasma pulmonis. TO mice in which chlamydial infection had been suppressed by the mycoplasma infection were treated with the anti-mycoplasma agent, gentamicin. This did not cause a reappearance of the chlamydiae, suggesting that these organisms had been eliminated completely. The M. pulmonis infection stimulated a striking and persistent polymorphonuclear leukocyte response, which may have been the cause of the curtailment of the chlamydial infection.
D000818:Animals; D002460:Cell Line; D002690:Chlamydia Infections / Q000150:complications* / Q000382:microbiology; D002692:Chlamydia trachomatis / Q000302:isolation & purification / Q000502:physiology; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use; D051379:Mice; D008808:Mice, Inbred CBA; D009174:Mycoplasma / Q000302:isolation & purification / Q000502:physiology; D009175:Mycoplasma Infections / Q000150:complications* / Q000382:microbiology; D009504:Neutrophils; D014621:Vagina / Q000382:microbiology / Q000473:pathology
D005839:Gentamicins