Efficacy of fenbendazole against migrating Ascaris suum larvae in pigs.
Twenty-four weanling crossbred pigs were inoculated with 10,000 embryonated Ascaris suum eggs. The infection was aborted in 1 group (n = 8 pigs) with fenbendazole (3 mg/kg of body weight) given on postinfection days 2, 3, and 4 and in a 2nd group (n = 8 pigs) given fenbendazole at the same rate on postinfection days 6, 7, and 8; a 3rd group (n = 8 pigs) was not treated with fenbendazole. All pigs were necropsied at 24 days after they were inoculated. Fenbendazole was 99% effective against A suum larvae in the 2 treated groups. Early treated pigs had significantly higher daily weight gains (P less than 0.05) and were 22% more efficient in feed conversion than were nontreated pigs. Lung weights increased linearly with length of exposure to migrating A suum larvae (P less than 0.10). Liver weights were greater in treated pigs than in non-treated pigs (P less than 0.01). A negative correlation existed between number of liver lesions and liver weights of all pigs (P less than 0.05).
D000818:Animals; D001196:Ascariasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D001200:Ascaris / Q000187:drug effects*; D001562:Benzimidazoles / Q000627:therapeutic use*; D005273:Fenbendazole / Q000494:pharmacology / Q000627:therapeutic use*; D007814:Larva / Q000187:drug effects; D008099:Liver / Q000469:parasitology; D008168:Lung / Q000469:parasitology; D013552:Swine; D013553:Swine Diseases / Q000188:drug therapy* / Q000469:parasitology
D001562:Benzimidazoles; D005273:Fenbendazole