[Studies on the mechanism of defective natural killer cytotoxicity in patients with multiple myeloma].
Multiple myeloma patients in the advanced or remission stage exhibit significantly lower natural killer (NK) activity than normal subjects. Single-cell assay showed that the number of active NK cells was the same for all patients. The maximum killing potential (Vmax) in advanced patients was lower than in normal subjects. These results suggest that defective NK activity in advanced patients is due to a reduced recycling capacity.
D000328:Adult; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D009101:Multiple Myeloma / Q000276:immunology*