Effects of branched-chain alpha-keto acids on plasma amino acid concentrations in carbon tetrachloride-intoxicated rats.
Plasma branched-chain amino acid levels during continuous intravenous infusion of sodium salts of branched-chain alpha-keto acid were much higher in CCl4-intoxicated rats than in control rats. However, increases after intragastric administration were diminished in both groups. Increased plasma alloisoleucine levels following administration of R,S-alpha-keto-beta-methylvaleric acid were reduced greatly by using only S-alpha-keto-beta-methylvaleric acid.
D000596:Amino Acids / Q000097:blood*; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000097:blood*; D004032:Diet; D005260:Female; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007441:Intubation, Gastrointestinal; D007532:Isoleucine / Q000097:blood; D007651:Keto Acids / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D000596:Amino Acids; D007651:Keto Acids; D007532:Isoleucine