Sinus histiocytosis with massive lymphadenopathy: response to cyclophosphamide therapy.
A patient with sinus histiocytosis with massive lymphadenopathy is described. After attempts to control lymph node size and constitutional symptoms with corticosteroids were unsuccessful with radiation therapy and nonsteroidal anti-inflammatory drugs, the patient was treated with two courses of low doses of oral cyclophosphamide therapy. He remains in complete remission 15 months after therapy was discontinued.
D000328:Adult; D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology; D003520:Cyclophosphamide / Q000627:therapeutic use*; D006801:Humans; D008198:Lymph Nodes / Q000187:drug effects / Q000473:pathology; D008206:Lymphatic Diseases / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009333:Neck
D003520:Cyclophosphamide