title: [Pharmacokinetic characteristics of zixoryn used in single and multiple doses].
abstract: Nine patients with normal live and renal functions were examined for the pharmacokinetics of zixorine after a single oral administration in a dose of 300 mg. In 7 of these patients given multiple doses of zixorine, its pharmacokinetics was reinvestigated. Six of the 7 patients manifested deceleration of drug biotransformation instead of expected self-induction of biotransformation. The reasons for such a phenomenon are discussed. Four patients were examined for the time course of zixorine biotransformation.
mesh_terms: D001559:Benzhydryl Compounds / Q000008:administration & dosage / Q000097:blood*; D001711:Biotransformation; D002849:Chromatography, Gas; D004790:Enzyme Induction / Q000187:drug effects; D006801:Humans; D007700:Kinetics; D008862:Microsomes, Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000096:biosynthesis; D013997:Time Factors
chemical_list: D001559:Benzhydryl Compounds; D006899:Mixed Function Oxygenases; C016914:flumecinol
vernacular_title: Osobennosti farmakokinetiki ziksorina pri ego odnorazovom i kursovom primenenii.