title: Gangliosides and related compounds as biological response modifiers.
abstract: Several possibilities are discussed with regard to the biological potency of gangliosides and related compounds as biological response modifier. Evidence is presented that a ganglioside, GQ1b, but not other gangliosides examined exhibits a strong biological activity at a few nanomolar concentration for the promotion of neurite outgrowth as well as cell division in two cell lines of neuroblastoma.
mesh_terms: D000818:Animals; D000906:Antibodies; D000954:Antigens, Surface / Q000276:immunology; D002460:Cell Line; D002462:Cell Membrane / Q000737:chemistry; D005732:Gangliosides / Q000276:immunology / Q000502:physiology*; D006028:Glycosphingolipids / Q000276:immunology; D007694:Killer Cells, Natural / Q000737:chemistry; D009414:Nerve Growth Factors; D009447:Neuroblastoma / Q000503:physiopathology
chemical_list: D000906:Antibodies; D000954:Antigens, Surface; D005732:Gangliosides; D006028:Glycosphingolipids; D009414:Nerve Growth Factors