[Physico-chemical properties of the erythrocyte membranes of normotensive and spontaneously hypertensive rats].
To detect the substrate of molecular alterations in a plasma membrane, found earlier to be typical of chronic hypertension, microcalorimetric study of erythrocyte membranes of spontaneously hypertensive rats was performed. It was found that characteristics of some irreversible therminal transitions in the membranes differ from the corresponding control values. The supposed predominant role of membrane protein denaturation in these transitions is confirmed by the analysis of temperature-dependent infrared spectra, spectra of membrane protein fluorescence and circular dichroism.
D000818:Animals; D002152:Calorimetry, Differential Scanning; D002352:Carrier Proteins / Q000378:metabolism*; D002942:Circular Dichroism; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005260:Female; D006358:Hot Temperature; D006973:Hypertension / Q000097:blood*; D008565:Membrane Proteins / Q000378:metabolism*; D051381:Rats; D013055:Spectrophotometry, Infrared
D002352:Carrier Proteins; D008565:Membrane Proteins
Issledovanie fiziko-khimicheskikh svoĭstv membrany éritrotsitov normotenzivnykh i spontanno gipertenzivnykh krys.