Effects of adrenergic drugs on aqueous humour dynamics in the normal human eye. I. Salbutamol.
The immediate effects of topical salbutamol, a beta 2 adrenergic agonist, on the aqueous humour dynamics of 22 normal subjects was studied by fluorophotometry and tonography. Significant lowering of intraocular pressure was accompanied by a significant increase in both aqueous flow rate and tonographic facility of outflow. Uveoscleral outflow was calculated and found to be significantly increased by salbutamol. This appeared to be the predominant acute pressure lowering effect of beta receptor stimulation in the normal human eye.
D000420:Albuterol / Q000494:pharmacology*; D000867:Anterior Chamber / Q000187:drug effects; D001082:Aqueous Humor / Q000187:drug effects*; D004058:Diffusion; D005260:Female; D005470:Fluorometry; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D007498:Iris / Q000187:drug effects; D008297:Male; D014065:Tonometry, Ocular
D000420:Albuterol