Ketanserin and vascular contractions in response to cooling.
Rings of tibial arteries of the rabbit were suspended for isometric tension recording in organ chambers filled with oxygenated physiological salt solution. 5-Hydroxytryptamine caused contractions which were enhanced by cooling from 37 to 29 degrees C. Both the contractions induced by 5-hydroxytryptamine and their augmentation by cooling were inhibited by similar concentrations of the serotonergic 5-HT2 antagonist ketanserin. These experiments demonstrate that cooling augments the responsiveness of peripheral arteries to 5-hydroxytryptamine and that the augmentation is mediated by 5-HT2 serotonergic receptors.
D000818:Animals; D001158:Arteries / Q000187:drug effects; D003080:Cold Temperature; D066298:In Vitro Techniques; D007650:Ketanserin; D010880:Piperidines / Q000494:pharmacology*; D011817:Rabbits; D012701:Serotonin / Q000502:physiology; D012702:Serotonin Antagonists / Q000494:pharmacology*; D014661:Vasoconstriction / Q000187:drug effects*
D010880:Piperidines; D012702:Serotonin Antagonists; D012701:Serotonin; D007650:Ketanserin