Length-dependent changes of pacemaker frequency in the isolated rabbit sinoatrial node.
To correlate changes in pacemaker frequency with those of length and tension in mammalian atrial tissues, a strip of the sinoatrial (SA) nodal tissue (about 10 mm in length and 4 mm in width) isolated from the rabbit heart was subjected to constant-length and constant-load stretches, and the relation between the resulting pacemaker frequency changes and the segmental length changes of the preparation was examined by means of cinematographic recording of the preparation with carbon markers on its surface. The amount of stretch-induced length changes was larger in the perinodal tissue segments than in the SA nodal segments, indicating that the nodal area is less extensible than the perinodal area. The time course of stretch-induced length changes of one nodal segment (closer to the inferior vena cava) was found to roughly parallel that of pacemaker frequency changes, suggesting that the pacemaker frequency is primarily dependent on the length but not on the tension of the SA nodal area.
D000818:Animals; D046508:Culture Techniques; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate; D008297:Male; D011817:Rabbits; D012849:Sinoatrial Node / Q000502:physiology*