title: A biphasic serum glucose response in mice to inoculation with pertussis vaccine.
abstract: The effect of B. pertussis vaccine on the serum glucose level of mice was investigated. The results show that at least two components in the vaccine interfere with glucose metabolism. A heat-stable component which is assumed to be LPS induced hypoglycemia 3-5.5 h after inoculation, especially in LPS-sensitized mice. A heat-labile component which is possibly equivalent with the LPF/HSF/IAP complex, is responsible for persistence of the hypoglycaemia for at least 6 days. If hypoglycaemia contributes to the neurological side effects after pertussis vaccination both components have to be considered as being responsible for these effects.
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000494:pharmacology; D001786:Blood Glucose / Q000032:analysis / Q000378:metabolism*; D022121:Cholera Vaccines / Q000494:pharmacology; D007003:Hypoglycemia / Q000097:blood / Q000209:etiology; D051379:Mice; D010567:Pertussis Vaccine / Q000494:pharmacology*; D013997:Time Factors; D014436:Typhoid-Paratyphoid Vaccines / Q000494:pharmacology; D014613:Vaccines, Attenuated / Q000494:pharmacology
chemical_list: D001500:BCG Vaccine; D001786:Blood Glucose; D022121:Cholera Vaccines; D010567:Pertussis Vaccine; D014436:Typhoid-Paratyphoid Vaccines; D014613:Vaccines, Attenuated