Sex differences in sensitization to cocaine-induced rotation.
Sensitization to cocaine- and d-amphetamine-induced rotation was studied in male and female rats. A single injection of cocaine (20 mg/kg) sensitized female rats to a subsequent dose administered 1 or 7 days later; sensitivity returned to normal within 14 days. Sensitization to cocaine did not occur in male rats nor to d-amphetamine in either sex.
D000818:Animals; D003042:Cocaine / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology; D004361:Drug Tolerance; D005260:Female; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D003042:Cocaine; D003913:Dextroamphetamine