Motility of the distal portion of the jejunum and pelvic flexure in ponies: effects of six drugs.
Bipolar stainless steel electrodes were surgically implanted in 4 ponies to record myoelectrical and mechanical activity of the distal portion of the jejunum and pelvic flexure. After determining normal activity, the effects of neostigmine, xylazine, flunixin meglumine, dipyrone, panthenol, and atropine sulfate were determined. Flunixin meglumine, dipyrone, and panthenol had no effect on the motility of the jejunum or pelvic flexure. Xylazine and atropine sulfate decreased motility of the distal portion of the jejunum and pelvic flexure, with atropine sulfate having a greater effect and lasting longer. Neostigmine stimulated propulsive motility in the pelvic flexure only.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D001285:Atropine / Q000494:pharmacology; D003002:Clonixin / Q000031:analogs & derivatives / Q000494:pharmacology; D003106:Colon / Q000502:physiology*; D004177:Dipyrone / Q000494:pharmacology; D004576:Electromyography / Q000662:veterinary; D004594:Electrophysiology; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006736:Horses / Q000502:physiology*; D007583:Jejunum / Q000187:drug effects / Q000502:physiology*; D009388:Neostigmine / Q000494:pharmacology; D010205:Pantothenic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology; D014991:Xylazine / Q000494:pharmacology
D000893:Anti-Inflammatory Agents; D010276:Parasympatholytics; D010205:Pantothenic Acid; C007288:dexpanthenol; D014991:Xylazine; D009388:Neostigmine; D004177:Dipyrone; D001285:Atropine; C014558:flunixin meglumine; D003002:Clonixin