title: Adenosine and adenosine analogues increase blood flow in oral mucosa.
abstract: The effect of adenosine and some related compound was studied on blood flow in feline oral mucosa. Changes in the rate of disappearance of 125Iodine (k-value) from a local depot in the oral mucosa was used to determine changes in the mucosal blood flow. Infusion of adenosine caused a dose-dependent increase of blood flow. Two stable adenosine analogues, adenosine 5'- ethylcarboxamide ( NECA ) and L-phenylisopropyl-adenosine (L-PIA), were 20 and 10 times more potent than the parent compound. Dipyridamole (2 mg/kg), which blocks adenosine uptake, significantly enhanced the potency of adenosine. Theophylline (10 mg/kg) inhibited the vasodilatory effect of adenosine and of the adenosine analogues. The result suggest that adenosine may be involved in the regulation of blood flow in the oral mucosa.
mesh_terms: D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology*; D019830:Adenosine-5'-(N-ethylcarboxamide); D000818:Animals; D002415:Cats; D004176:Dipyridamole / Q000494:pharmacology; D009061:Mouth Mucosa / Q000098:blood supply*; D010660:Phenylisopropyladenosine / Q000494:pharmacology; D011687:Purines / Q000097:blood; D012039:Regional Blood Flow / Q000187:drug effects; D013806:Theophylline / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D011687:Purines; D010660:Phenylisopropyladenosine; D019830:Adenosine-5'-(N-ethylcarboxamide); D004176:Dipyridamole; D013806:Theophylline; D000241:Adenosine