title: Effect of Zajdela ascites hepatoma on the activity and synthesis of liver histidase of tumor-bearing rats.
abstract: The synthesis of histidase occurs only in free polyribosomes. The relative content of histidase synthesizing polyribosomes in rat liver, in Zajdela ascites hepatoma cells and in the liver of tumor-bearing rats is equal to 1.35%, 0.11% and 0.57%, respectively (of the total amount of free polyribosomes). It was found that hepatoma cell sap has an inhibitory effect on the synthesis of proteins in the cell-free system reconstructed from polyribosomes and cell sap of control rats.
mesh_terms: D000642:Ammonia-Lyases / Q000096:biosynthesis*; D000818:Animals; D001921:Brain / Q000378:metabolism; D002458:Cell Fractionation; D002460:Cell Line; D006638:Histidine Ammonia-Lyase / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D008099:Liver / Q000201:enzymology*; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D008297:Male; D009368:Neoplasm Transplantation; D011132:Polyribosomes / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014020:Tissue Extracts / Q000494:pharmacology*
chemical_list: D014020:Tissue Extracts; D000642:Ammonia-Lyases; D006638:Histidine Ammonia-Lyase