title: Pyrithione: plasma metabolite in man.
abstract: 2-Methylsulfonylpyridine (2-MSP) has been identified as the terminal plasma pyrithione metabolite in rats, rabbits, dogs, and monkeys (W. B. Gibson, A. R. Jeffcoat, P. D. Rodriguez, T. S. Turan, P. F. Hughes, and M. E. Twine, Toxicol. Appl. Pharmacol. 62, 237-250 (1982); C. Mitoma, T. Steeger, J. Rogers, D. Thomas, and J. H. Wedig, Fundam. Appl. Toxicol. 3, 256-263 (1983]. This metabolite was detected in the systemic circulation of humans involved in the chemical manufacturing process. This confirms that the terminal pyrithione metabolite in plasma is identical among rat, rabbit, dog, monkey, and man.
mesh_terms: D000328:Adult; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D004781:Environmental Exposure; D006207:Half-Life; D006801:Humans; D008297:Male; D011725:Pyridines / Q000097:blood*; D013871:Thiones
chemical_list: D011725:Pyridines; D013871:Thiones; C008704:pyrithione