Alterations in the lipid and lipoprotein composition of prairie dogs fed a high cholesterol diet.
Cholesterol feeding induced a marked hypercholesterolemia with a significant change in the chemical composition of different lipid and lipoprotein fractions. The change of lipoprotein composition in the prairie dog resembles that of human hyper-beta-lipoproteinemia. It is assumed that the mechanism of gallstone formation in humans is not identical to that of the prairie dog. The absolute increase in the hepatic free cholesterol in the prairie dog is due to the dietary cholesterol while the relative increase in free cholesterol in humans is due to a high FC/EC which is probably due to a defect in cholesterol esterification or cholesterol ester hydrolyzing activity.
D000818:Animals; D002791:Cholesterol, Dietary / Q000378:metabolism*; D004036:Diet, Atherogenic; D004195:Disease Models, Animal; D005227:Fatty Acids / Q000097:blood; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008297:Male; D012589:Sciuridae / Q000097:blood*; D002785:Sterol O-Acyltransferase / Q000378:metabolism
D002791:Cholesterol, Dietary; D005227:Fatty Acids; D008055:Lipids; D008074:Lipoproteins; D002785:Sterol O-Acyltransferase