Control of spontaneous and deoxycorticosterone-salt hypertension and polyuria by nitrendipine pellets.
Weekly subcutaneous implantation of 25-mg nitrendipine pellets prevented onset of both spontaneous and deoxycorticosterone-salt hypertension in rats. Discontinuance of implantation led to reappearance of hypertension after about 2 weeks in the former and led to rising though still normotensive pressures after about 3 weeks in the latter. A new implant caused blood pressures in both to drop within a day or two to normotensive levels in the case of spontaneously hypertensive rats. Nitrendipine prevented cardiac hypertrophy in steroid hypertensive rats, but not in spontaneous hypertensives. A nitrendipine pellet given 1 day before or a 30 mg/kg injection given 1 h prior to the administration of a water, Na+, and K+ load, prevented the diabetes insipidus-like syndrome resulting from deoxycorticosterone-salt treatment, and lowered sodium but not potassium excretion. Nitrendipine did not affect steroid-induced hypernatremia and hypokalemia.
D000818:Animals; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D003900:Desoxycorticosterone; D005260:Female; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy*; D009543:Nifedipine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D009568:Nitrendipine; D009929:Organ Size / Q000187:drug effects; D011141:Polyuria / Q000139:chemically induced / Q000188:drug therapy*; D011188:Potassium / Q000097:blood; D051381:Rats; D011919:Rats, Inbred Strains; D012964:Sodium / Q000097:blood; D013997:Time Factors
D000959:Antihypertensive Agents; D003900:Desoxycorticosterone; D009568:Nitrendipine; D012964:Sodium; D009543:Nifedipine; D011188:Potassium