[Analysis of the mechanisms of the anti-arrhythmic action of marcaine and lidocaine].
It has been demonstrated in experiments on anesthetized cats with heart rhythm abnormalities induced by the creation of an "ectopic focus" by high-frequency electric stimulation of the ventricles that lidocaine in a dose of 5.8 mg/kg is inferior to marcaine in a dose of 1.3 mg/kg as regards the ability to inhibit the sympathetic tone. Lidocaine and marcaine have been discovered to produce different effects: lidocaine produced a dose-dependent selective inhibition of C-components of reflex discharges, whereas marcaine a more prolonged and uniform suppression of both A- and C-components of evoked responses, inhibiting both excitatory and inhibitory components of reflex responses.
D000779:Anesthetics, Local / Q000627:therapeutic use*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D002045:Bupivacaine / Q000627:therapeutic use*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects / Q000294:innervation; D008012:Lidocaine / Q000627:therapeutic use*; D013564:Sympathetic Nervous System / Q000187:drug effects; D014693:Ventricular Fibrillation / Q000188:drug therapy
D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D008012:Lidocaine; D002045:Bupivacaine
K analizu mekhanizmov protivoaritmicheskogo deĭstviiia markaina i lidokaina.