title: Microbial biodegradation of 4-chlorobiphenyl, a model compound of chlorinated biphenyls.
abstract: The biodegradation products of 4-chlorobiphenyl were analyzed in an Achromobacter sp. strain and a Bacillus brevis strain. Both strains generated the same metabolites, with 4-chlorobenzoic acid as the major metabolic product. Our results corroborate previous observations whereby most bacterial strains degrade the chlorobiphenyls via a major pathway which proceeds by an hydroxylation in position 2,3 and a meta-1,2 fission. However, we also detected several metabolites whose structure suggests the existence of other routes for the degradation of chlorinated biphenyls.
mesh_terms: D000421:Alcaligenes / Q000235:genetics / Q000378:metabolism*; D001407:Bacillus / Q000235:genetics / Q000378:metabolism*; D001673:Biodegradation, Environmental; D001713:Biphenyl Compounds / Q000378:metabolism*; D002723:Chlorobenzoates / Q000378:metabolism*; D004269:DNA, Bacterial / Q000032:analysis; D004591:Electrophoresis, Polyacrylamide Gel; D008401:Gas Chromatography-Mass Spectrometry; D006900:Hydroxylation; D008954:Models, Biological; D010957:Plasmids
chemical_list: D001713:Biphenyl Compounds; D002723:Chlorobenzoates; D004269:DNA, Bacterial; C040768:4-chlorobenzoic acid; C006983:4-chlorobiphenyl