title: Abuse of a fire-extinguishing agent and sudden death in adolescents.
abstract: Two cases of abuse of bromochlorodifluoromethane (BCF - a fire-extinguishing agent) by inhalation are reported. In the first case, a 15-year-old youth presented in ventricular fibrillation; the second youth was dead on arrival at hospital. Port-mortem toxicological investigations confirmed BCF inhalation in the latter patient. Management of the surviving patient included cardioversion, controlled mandatory hyperventilation, intravenous infusions of mannitol, and barbiturate protection against cerebral ischaemia. He had completely recovered after eight days. Community agencies report that BCF inhalation occurs frequently on the Gold Coast, Queensland. This behaviour can be associated with sudden death from ventricular arrhythmias after cardiac sensitization to endogenous adrenaline. The "lone sniffer" is at greatest risk, and identification of such individuals may prevent a fatal outcome.
mesh_terms: D000293:Adolescent; D002545:Brain Ischemia / Q000139:chemically induced / Q000628:therapy; D064228:Bromochlorofluorocarbons; D005617:Chlorofluorocarbons, Methane / Q000506:poisoning; D003645:Death, Sudden / Q000209:etiology*; D005388:Fire Extinguishing Systems; D006801:Humans; D008297:Male; D019966:Substance-Related Disorders / Q000150:complications*; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000628:therapy
chemical_list: D064228:Bromochlorofluorocarbons; D005617:Chlorofluorocarbons, Methane; C037990:bromochlorodifluoromethane