Rapid synthesis of 26-hydroxycholesterol from mevalonic acid in the Syrian hamster.
Using isotope-ratio mass spectrometry, newly synthesized 26-hydroxycholesterol and its derivative, 3 beta-hydroxy-5-cholenoic acid, were detected in the liver and bile of animals within 2 h following intravenous administration of [5-13C]mevalonic acid. The findings indicate that 26-hydroxycholesterol merits further consideration as an in vivo modulator of HMG-CoA reductase activity.
D000818:Animals; D001646:Bile / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D006888:Hydroxycholesterols / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008798:Mevalonic Acid / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D006888:Hydroxycholesterols; C007042:cholest-5-ene-3 beta,26-diol; D008798:Mevalonic Acid