Reversible motor paralysis in rats after repeated electroconvulsive shock.
Repeated electroconvulsive shocks (ECS) delivered at brief (10 to 15 min) intervals through earclip electrodes, induced a reversible motor paralysis in 35% of treated rats. Paralysis was characterized by loss of locomotor activity without apparent loss of sensory functions. It occurred after 10 to 13 shocks regardless of whether stimulation was of subthreshold (40 to 60 mA) or suprathreshold (65 mA) intensity. This phenomenon may provide a useful animal model for the investigation of reversible injury to the spinal cord.
D000818:Animals; D004597:Electroshock; D008297:Male; D009069:Movement Disorders / Q000209:etiology / Q000503:physiopathology*; D010243:Paralysis / Q000209:etiology / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000209:etiology / Q000503:physiopathology; D013997:Time Factors