Conserved linkage within a 4-cM region of mouse chromosome 9 and human chromosome 11.
A six-point cross was carried out to determine the gene order and distances among loci on mouse chromosome 9. Our results are consistent with the following arrangement: centromere - Lap-1 - (1.2 +/- 0.8) - Es-17 - (3.0 +/- 1.0) - Ups - (1.3 +/- 0.7) - Alp-1 - (23.1 +/- 3.4) - Mod-1 - (10.9 +/- 2.6) - Acy-1. This study provides the first estimate of the distances between Es-17, Ups and Alp-1. Exceptions to the preferred association of alleles of Es-17 and Ups have been found in three feral populations and one inbred strain. Evidence is presented for the homology of this chromosome region with the ESA4 - UPS - APO-AI region on the long arm of human chromosome 11.
D000115:Acetylesterase / Q000235:genetics; D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes; D002906:Chromosomes, Human, 6-12 and X; D004586:Electrophoresis; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D011163:Hydroxymethylbilane Synthase / Q000235:genetics; D007525:Isoelectric Focusing; D051379:Mice; D008815:Mice, Inbred Strains; D010641:Phenotype
D011163:Hydroxymethylbilane Synthase; D000115:Acetylesterase