Efficacy of absorption of sublingual and intravenous Cardio-Green.
To simulate the effect of sublingual injections on pediatric patients, open-chested kid goats were injected sublingually or peripherally with Cardio-Green while being supported by internal cardiac massage. Our study demonstrates that there is statistically a ten-fold lower central blood level after sublingual injection compared to that after use of the peripheral intravenous route. Our experiment casts doubt on whether absorption through the sublingual route is adequate, and shows that if a peripheral intravenous line cannot be started, vigorous attempts should be made to obtain a central line rather than taking valuable time to inject sublingual drugs. Further studies must be done before these results can be applied to clinical situations.
D000042:Absorption; D000818:Animals; D006041:Goats; D006336:Heart Massage; D007208:Indocyanine Green / Q000008:administration & dosage* / Q000097:blood; D007267:Injections; D007275:Injections, Intravenous; D008954:Models, Biological; D009060:Mouth Floor
D007208:Indocyanine Green