[Postradiation disorders in the adenine-phosphoribosyltransferase pathway of AMP biosynthesis].
A study was made of the activity of adenine-phosphoribosyltransferase (EC 2.4.2.7), which catalizes the biosynthesis of AMP from adenine and 5-phospho-alpha-D-riboso-1-diphosphate, in extracts from thymus and liver during 24 h following irradiation of mice in a dose of 245.1 mC/kg (dose-rate of 9.16 X 10(-4)-9.0 X 10(-4) A/kg). Adenine-phosphoribosyltransferase activity of liver remains normal during the entire period of observation. In thymus extracts, the activity of the enzyme decreases down to 70-80% of the control level 3 h after irradiation, it is normalized after 6 h and increases up to 150-160% of the control level by the end of the first day of radiation sickness.
D000228:Adenine Phosphoribosyltransferase / Q000378:metabolism*; D000818:Animals; D003037:Cobalt Radioisotopes; D005720:Gamma Rays; D008099:Liver / Q000201:enzymology*; D008297:Male; D051379:Mice; D010430:Pentosyltransferases / Q000378:metabolism*; D011833:Radiation Injuries, Experimental / Q000201:enzymology*; D013950:Thymus Gland / Q000201:enzymology*
D003037:Cobalt Radioisotopes; D010430:Pentosyltransferases; D000228:Adenine Phosphoribosyltransferase
Postradiatsionnye narusheniia adenin-fosforiboziltransferaznogo puti biosinteza AMF.