Arthritis and autoimmune pancytopenia.
We report a patient who developed arthritis and pancytopenia without an underlying systemic disease. Autoantibodies to all lines were demonstrated using an 125I-anti human IgG assay. Elution studies documented cross reactivity of an antibody between erythrocytes and platelets, a pathogenetic variation not previously reported.
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000150:complications*; D001323:Autoantibodies / Q000032:analysis; D001792:Blood Platelets / Q000276:immunology; D003429:Cross Reactions; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008297:Male; D009504:Neutrophils / Q000276:immunology; D010198:Pancytopenia / Q000150:complications* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use
D001323:Autoantibodies; D007074:Immunoglobulin G; D007770:L-Lactate Dehydrogenase; D011241:Prednisone