Experimental choreoathetosis produced by injection of a gamma-aminobutyric acid antagonist into the lentiform nucleus in the monkey.
An experiment is reported in which injections of the gamma-aminobutyric acid antagonist bicuculline into the lentiform nucleus of the monkey gave rise to a contralateral choreoathetoid dyskinesia. Evidence was obtained of functional heterogeneity between the dorsal and ventral lentiform nucleus, in that only injections into its ventral part gave rise to dyskinesia.
D000818:Animals; D001264:Athetosis / Q000139:chemically induced*; D001640:Bicuculline / Q000633:toxicity*; D002819:Chorea / Q000139:chemically induced*; D004195:Disease Models, Animal; D008254:Macaca nemestrina; D011699:Putamen / Q000187:drug effects*
D001640:Bicuculline