title: [Ultrastructural study of the local changes induced in the white rat by the venom of Bothrops picadoi of Costa Rica].
abstract: The pathogenesis of local lesions induced by Bothrops picadoi venom was studied at the electron microscopic level. White mice were injected i.m. with 100 micrograms of venom. A strong hemorrhagic action was the earliest and most prominent local effect observed in this study. In skeletal muscle fibers, rupture of the sarcolemma was observed and myofibril structure was drastically affected, showing amorphous masses of myofilaments. Myelin layers in many axons were disorganized.
mesh_terms: D000818:Animals; D001369:Axons / Q000648:ultrastructure; D003435:Crotalid Venoms / Q000633:toxicity*; D006470:Hemorrhage / Q000473:pathology; D009474:Neurons / Q000648:ultrastructure; D051381:Rats; D012867:Skin / Q000473:pathology; D012909:Snake Bites / Q000473:pathology*
chemical_list: D003435:Crotalid Venoms
vernacular_title: Estudio ultraestructural de las alteraciones locales inducidas en ration blanco por el veneno de Bothrops picadoi de Costa Rica.