Failure of tetracaine to reverse spinal cord injury in the cat.
Beginning 30 minutes after acute spinal cord injury, cats were treated by the administration of continuous spinal anesthesia for 8 hours. This was achieved by the intermittent injection of hyperbaric tetracaine into the subarachnoid space at the site of injury via an indwelling catheter. There were no significant differences in functional recovery or histologically assessed tissue preservation between treated cats and concurrently managed control animals. The indwelling subarachnoid catheter used for drug administration was found to have no significant effect on the spinal cord injury.
D000287:Administration, Topical; D000818:Animals; D002415:Cats; D004353:Drug Evaluation, Preclinical; D008297:Male; D013119:Spinal Cord Injuries / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D013748:Tetracaine / Q000627:therapeutic use*
D013748:Tetracaine