title: The Cd technique identifies a specific structure related to centromeric function.
abstract: The evidence that the Cd technique identifies the kinetochore was based on the finding that inactive centromeres are C-positive but Cd-negative. The identity between Cd-positivity and centromere function is now confirmed by the reverse procedure: a stable abnormal chromosome is consistently C-negative but Cd-positive at its single centromeric constriction. This demonstrates that the Cd dots are not a relic of C-banding but identify the active centromere.
mesh_terms: D002503:Centromere; D002675:Child, Preschool; D002871:Chromosome Banding; D002875:Chromosomes; D002900:Chromosomes, Human, 1-3 / Q000648:ultrastructure*; D002902:Chromosomes, Human, 16-18 / Q000648:ultrastructure*; D005260:Female; D006801:Humans