Interaction between quercetin and Ca2+-calmodulin complex: possible mechanism for anti-tumor-promoting action of the flavonoid.
Quercetin was found to have similar inhibitory effects on tumor promoter-induced phenomena to those of N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide, a calmodulin antagonist. Moreover, quercetin was shown to interact directly with the Ca2+-calmodulin complex. These results suggest that quercetin may act as a calmodulin antagonist, and that its antagonistic effect on calmodulin may be important in its anti-tumor-promoting action in vivo.
D000818:Animals; D002147:Calmodulin / Q000037:antagonists & inhibitors*; D002478:Cells, Cultured; D002642:Chick Embryo; D003847:Deoxyglucose / Q000378:metabolism; D004347:Drug Interactions; D005347:Fibroblasts / Q000378:metabolism; D005419:Flavonoids / Q000494:pharmacology*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D011794:Quercetin / Q000494:pharmacology*; D013449:Sulfonamides / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology
D002147:Calmodulin; D005419:Flavonoids; D013449:Sulfonamides; C017967:W 7; D003847:Deoxyglucose; D011794:Quercetin; D013755:Tetradecanoylphorbol Acetate