title: [Characteristics of the effect of nicotine on the mother-fetus system in exposure over the course of the entire pregnancy].
abstract: Experiments on Wistar rats were made to study the effects of nicotine administered in doses of 0.4, 1.5, and 5 mg/kg (1/70, 1/20 and 1/5 of the LD50) on the functional state of the mother's body and embryogenesis under exposure throughout the entire pregnancy. The mother demonstrated abnormalities of nervous and cardiovascular functions, which were dose-dependent. Nicotine was shown to have an adverse effect on the formation of the cardiovascular system in embryos and ossification in the bone skeleton. The cardiovascular system tended towards an "organ to organ" injury within the mother-embryo system.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects / Q000196:embryology; D004305:Dose-Response Relationship, Drug; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D009538:Nicotine / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
chemical_list: D009538:Nicotine
vernacular_title: Osobennosti vliianiia nikotina na sistemu mat'-plod pri vozdeĭstvii v techenie vseĭ beremennosti.