title: Mineral metabolism during short-term starvation in man.
abstract: Plasma and urine electrolytes were measured in five healthy non-obese young adults before, during and after a four-day period of total starvation (distilled water only). Plasma sodium, chloride and bicarbonate concentrations decreased in all subjects by a mean value of 4 mmol/l, whereas the sum of acetoacetate and hydroxybutyrate concentrations increased by 4-6 mmol/l. These changes occurred without alterations in the state of hydration or vascular volume. Hydroxybutyrate and ammonium ions became the main urinary ions during starvation, whereas sodium and chloride, which were quantitatively the most important urinary electrolytes before starvation, decreased four-fold, and potassium two-fold. Plasma zinc concentrations rapidly increased in all subjects by a mean of 4 mumol/1 (25%) and returned to normal on refeeding. The excretion of zinc in urine trebled and continued to rise on refeeding. There were no major changes in the excretion of calcium, magnesium, phosphate or sulphate during the starvation period. From knowledge of the intracellular concentrations of various minerals and extent of breakdown of lean tissues (N excretion), it is suggested that most of the urinary calcium, magnesium and phosphate probably originates from bone, and that the amount of zinc in urine is only a small fraction of that which is likely to be released from the breakdown of lean tissues. It is also suggested that the continued excretion of zinc on refeeding is due to release of zinc from tissues which 'buffered' it during the starvation period. This study provides useful data in non-obese individuals with which to compare changes which occur in post-traumatic and post-infective starvation.
mesh_terms: D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000378:metabolism; D004573:Electrolytes / Q000097:blood / Q000378:metabolism* / Q000652:urine; D005502:Food; D006801:Humans; D007657:Ketone Bodies / Q000652:urine; D008297:Male; D008903:Minerals / Q000378:metabolism*; D009584:Nitrogen / Q000652:urine; D013217:Starvation / Q000378:metabolism*; D013997:Time Factors; D015032:Zinc / Q000097:blood
chemical_list: D001798:Blood Proteins; D004573:Electrolytes; D007657:Ketone Bodies; D008903:Minerals; D015032:Zinc; D009584:Nitrogen