title: Flunitrazepam as an induction agent in children. A clinical and pharmacokinetic study.
abstract: Flunitrazepam was studied as an induction agent in paediatric patients. The onset of action was slow and its efficacy uncertain following single doses of 0.03 mg kg-1(n = 4), or 0.04 mg kg-1 (n = 6) i.v. Long-lasting sedative effects were observed following operation. A strong anterograde but not retrograde amnesic effect was obtained, and a possible analgesic sparing property. Flunitrazepam has a faster and more extensive tissue distribution and a more rapid elimination (half-life about 12 h) in children than in adults.
mesh_terms: D000768:Anesthesia, General; D002648:Child; D002675:Child, Preschool; D005445:Flunitrazepam / Q000378:metabolism / Q000494:pharmacology; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D013997:Time Factors
chemical_list: D005445:Flunitrazepam