[Intracellular hormonal function of acetylcholine and noradrenaline: the regulation of the catalase level in liver cells].
The injection of acetylcholine (15 to 150 micrograms/100 g) to rats or preincubation in the hepatic homogenate with acetylcholine (10(-6) to 10(-3) M) induces a decrease in the catalase activity, mainly in its bound form. Acetylcholine effect does not manifest in the presence of actinomycine D and puromycine. Noradrenaline injection to animals (1.5 to 15 micrograms/100 g) or preincubation of the hepatic homogenate with noradrenaline (10(-6) to 10(-3) M) produces a rise of the catalase activity (mainly of its bound form), being blocked by actinomycine D and non-blocked by propranolol. Acetylcholine- and noradrenaline action on the catalase level is not mediated by cyclic nucleotides and may be considered as intracellular hormonal effect.
D000109:Acetylcholine / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D002374:Catalase / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D005609:Free Radicals; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D009638:Norepinephrine / Q000494:pharmacology / Q000502:physiology*; D051381:Rats; D013347:Subcellular Fractions / Q000187:drug effects / Q000201:enzymology
D005609:Free Radicals; D002374:Catalase; D000109:Acetylcholine; D009638:Norepinephrine
K vnutrikletochnoĭ gormonal'noĭ funktsii atsetilkholina i noradrenalina: reguliatsiia urovnia katalazy v kletkakh pecheni.