Differentiation in dystrophic muscle cultures from mice of different ages.
Muscle from dystrophic (129 ReJ dy/dy) mice, aged 1, 2, 3, 4, and 6 months, was cocultured with normal embryonic mouse spinal cord. Cultures were scored for regeneration (myotubes) and differentiation (cross-striated or contracting fibers) over a 28-day period. Although muscle from dystrophic mice of all ages was able to regenerate, the ability to differentiate decreased with the increasing age of the mouse. Muscle from litter-mate control mice of different ages regenerated and differentiated equally well.
D000367:Age Factors; D000818:Animals; D002478:Cells, Cultured; D051379:Mice; D009132:Muscles / Q000166:cytology / Q000473:pathology*; D009137:Muscular Dystrophy, Animal / Q000473:pathology*; D012038:Regeneration