Absence of transformation of beta-muricholic acid by human microflora implanted in the digestive tracts of germfree male rats.
Germfree rats biosynthetize cholic and beta-muricholic acids. The latter does not exist in humans. Germfree rats were given human fecal suspensions. These rats degraded cholic acid into deoxycholic acid but failed to metabolize beta-muricholic acid.
D000818:Animals; D001419:Bacteria / Q000378:metabolism*; D001711:Biotransformation; D019826:Cholic Acid; D002793:Cholic Acids / Q000378:metabolism*; D002849:Chromatography, Gas; D003840:Deoxycholic Acid / Q000096:biosynthesis; D004064:Digestive System / Q000378:metabolism / Q000382:microbiology*; D005243:Feces / Q000382:microbiology*; D005260:Female; D005856:Germ-Free Life; D006801:Humans; D008297:Male; D051381:Rats
D002793:Cholic Acids; D003840:Deoxycholic Acid; C004821:muricholic acid; C010471:hyodeoxycholic acid; D019826:Cholic Acid