title: Effects of angiotensins of the motility of human sperm.
abstract: The effects of angiotensins on the motility of highly washed human sperm were examined by multiple exposure photography system. The addition of low doses (0.1-10 ng/ml) of angiotensin II (AT II) stimulated the forward velocity of sperm without increasing the percentage of motility. On the contrary, high concentration (1.0 micrograms/ml) of AT II suppressed the motility. The direct effect of angiotensin I (AT I) on the motility was observed under the presence of SQ 14225, a specific inhibitor of angiotensin I converting enzyme (ACE). At I (0.1-100 ng/ml) gave no influence on the motility, whereas that of high dose (1.0 ug/ml) suppressed the motility in the same manner as the corresponding dose of AT II. The action of AT II on the motility was completely suppressed under the coexistence of saralasin, a specific antagonist against AT II. This fact indicated that the action of AT II on the sperm appeared through the specific receptor on sperm.
mesh_terms: D000803:Angiotensin I / Q000494:pharmacology*; D000804:Angiotensin II / Q000494:pharmacology*; D000809:Angiotensins / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D012504:Saralasin / Q000494:pharmacology; D013081:Sperm Motility / Q000187:drug effects*
chemical_list: D000809:Angiotensins; D000804:Angiotensin II; D000803:Angiotensin I; D012504:Saralasin