[Acute experimental pyelonephritis. Treatment with tobramycin. Influence of the rhythm of administration on efficacy and renal tolerability].
Acute experimental pyelonephritis was produced in rabbits by injecting E. coli (tobramycin MIC 1 mg/l) into the left kidney and temporarily obstructing the ureter. Animals were given 10 mg/kg tobramycin intramuscularly 48 h after surgery and subsequently every day for 7, 10 or 15 days, either in a single daily dose or in three divided doses at 8 h intervals. Animals were killed 24 h after the last injection. Comparison of results shows that kidneys were sterilized by a single daily dose but not by three divided daily doses. In rabbits given the single daily dose regimen, kidneys recovered a normal macroscopical and histological aspect, serum anti-E. coli antibodies rose more slowly and less significantly, serum creatinine increased less, and renal enzymatic activities were restored (alanine aminopeptidase and N-acetyl-beta-D-glucosaminidase). These findings suggest better efficacy and renal tolerance of the single daily dose regimen as compared to the three daily divided dose regimen in the treatment of acute experimental pyelonephritis.
D000818:Animals; D004334:Drug Administration Schedule; D007273:Injections, Intramuscular; D007674:Kidney Diseases / Q000139:chemically induced / Q000473:pathology; D008297:Male; D011704:Pyelonephritis / Q000188:drug therapy*; D011817:Rabbits; D014031:Tobramycin / Q000008:administration & dosage* / Q000627:therapeutic use / Q000633:toxicity
D014031:Tobramycin
Pyélonéphrite aiguë expérimentale. Traitement par tobramycine. Influence du rythme d'administration sur l'efficacité et la tolérance rénale.