Vascular pathology in phenylbutazone intoxicated horses.
Three mature Thoroughbred geldings were given 13.63 mg phenylbutazone/Kg bodyweight intravenously for 3 days and repeated in one horse 4 days later. After 4, 7 and 10 days (double treatment), degeneration of the wall of small veins occurred in all horses. The veins were dilated and/or showed hyalin degeneration. The phlebopathy was interpreted to be paramount in phenylbutazone intoxication. All other manifestations, including erythro- and leukodiapedesis, submucosal edema and ulceration of the gastrointestinal mucosa, phlebothrombosis and significant changes in the hemogram and serum chemistry, were considered secondary to the vein lesions.
D000818:Animals; D006734:Horse Diseases / Q000139:chemically induced* / Q000473:pathology; D006736:Horses; D008297:Male; D010653:Phenylbutazone / Q000506:poisoning*; D014652:Vascular Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary*; D014680:Veins / Q000187:drug effects / Q000473:pathology
D010653:Phenylbutazone