N-Nitroso(2-hydroxyethyl)glycine, a urinary metabolite of N,N-dinitrosopiperazine with potential utility as a monitor for its formation in vivo from piperazine.
Urinary metabolites in the rat of the carcinogen N,N-dinitrosopiperazine were identified as N-nitroso(2-hydroxyethyl)-glycine (22% of the dose), N-nitrosodiethanolamine (3%), 3-hydroxy-N-nitrosopyrrolidine (3%), and unchanged N,N-dinitrosopiperazine (18%). N-Nitroso(2-hydroxyethyl)glycine (1.6 mumol) was detected by gas chromatography-nitrosamine specific detection in the urine of rats treated by gavage with 19 mumol of piperazine and 191 mumol of sodium nitrite. Since sensitive methods are available to quantify N-nitroso(2-hydroxyethyl)glycine in rat urine and human urine, it has potential utility as a monitor for in vivo formation of N,N-dinitrosopiperazine.
D000818:Animals; D002273:Carcinogens / Q000378:metabolism*; D002849:Chromatography, Gas; D008297:Male; D009602:Nitrosamines / Q000378:metabolism*; D009603:Nitroso Compounds / Q000652:urine*; D010879:Piperazines / Q000378:metabolism*; D051381:Rats
D002273:Carcinogens; D009602:Nitrosamines; D009603:Nitroso Compounds; D010879:Piperazines; C038290:N-(2-hydroxyethyl)-N-carboxymethylnitrosamine; C026156:N,N'-dinitrosopiperazine