[The 5- and 10-year survival and long-term effects of radical radiotherapy in patients with stage I-III Hodgkin's disease].
Radical radiation treatment was given to 152 patients suffering from stage I-III Hodgkin's disease in 1967-1977. Exposure was limited to the lymph collectors above the diaphragm in cases of stage I tumor. Exposure was extended to para-aortal lymph nodes and spleen (or splenic base) in cases of stage II tumor. All three levels were irradiated in cases of stage III. Mean five-year survival rate in the entire group was 89% (stage I-93: IIA-92.8 and IIIA-82.3%); ten-year rate-66.6%. Recurrences were detected in 43.5%; 75% of them were identified within the first two years after radiation. Relapse was more frequent in cases of mixed cell pattern of tumor and lymphoid depletion. Radiation-induced injuries of varying degree were found in 28%, changes in the lungs and soft tissues were prevalent. A relationship between radiation injury frequency and the extent of exposure was established: radiation injury was observed in 4% of stage I cases and in 63% of patients with stage III tumor. Radiation-induced malignancies (breast cancer and fibrosarcoma of ilioinguinal soft tissues) were found in two cases out of 152 at different periods of the study.
D000293:Adolescent; D000328:Adult; D003964:Diaphragm; D005260:Female; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000401:mortality / Q000532:radiotherapy*; D006801:Humans; D008198:Lymph Nodes / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced; D010493:Pericarditis / Q000209:etiology; D011014:Pneumonia / Q000209:etiology; D011832:Radiation Injuries; D011879:Radiotherapy Dosage; D012008:Recurrence; D013997:Time Factors
Piati-, desiatiletnie rezul'taty lecheniia i otdalennye posledstviia luchevoiĭ terapii po radikal'noĭ programme bol'nykh limfogranulematozom I-III stadiĭ.