Cytogenetic analysis of lymphocytes from rats following formaldehyde inhalation.
Male and female Fischer-344 rats were exposed to target concentrations of 0.5, 6, or 15 ppm formaldehyde by inhalation for 6 h/day for 5 days. Blood was removed by cardiac puncture within 1 h following termination of exposures and cultured in the presence of 5-bromodeoxyuridine (BrdU) (4 microM) for analyses of sister-chromatid exchange (SCE) and chromosome breakage. Formaldehyde did not cause a statistically significant increase in either SCE frequency or in the number of metaphases displaying chromosome aberrations.
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects*; D005260:Female; D005557:Formaldehyde / Q000097:blood / Q000633:toxicity*; D005740:Gases; D008214:Lymphocytes / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D012854:Sister Chromatid Exchange / Q000187:drug effects
D005740:Gases; D005557:Formaldehyde