Unique [3H]tryptamine binding sites in rat brain: distribution and pharmacology.
[3H]Tryptamine binding in rat brain is widely distributed with highest densities in the cortex, striatum and hippocampus. This binding is stereospecific and is potently displaced by tryptamine analogues and beta-carbolines. Phenethylamines also possess a weaker activity in displacing [3H]tryptamine. The strict structural requirements for binding to this site substantiate its unique character and suggest that it may represent a tryptamine receptor in the CNS.
D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism*; D002243:Carbolines / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D010627:Phenethylamines / Q000494:pharmacology; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects / Q000378:metabolism*
D002243:Carbolines; D010627:Phenethylamines; D011985:Receptors, Serotonin