title: Chromosome fragility in Bloom's syndrome cell line GM 1492.
abstract: Chromosomal aberrations in skin fibroblasts from Bloom's syndrome cell line GM 1492 are described. As expected, the sister chromatid exchange (SCE) frequency was high. Four very common chromosomal rearrangements included dup( 6q ), t(13;15), dic(16), and del(11q). The nucleolar organizer regions (NOR) in the dicentric t(13;15) were active. The increased incidence of chromosomal markers suggests an evolution of clones in the cell line.
mesh_terms: D001816:Bloom Syndrome / Q000235:genetics*; D002460:Cell Line; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D006801:Humans; D007621:Karyotyping; D008297:Male; D012854:Sister Chromatid Exchange