[Long-term cross-circulation on galactosamine induced hepatic failure rats].
Cross-circulation was carried out in between galactosamine treated hepatic failure rats and normal rats and its efficacy was mainly evaluated by measuring mitochondrial respiratory function of the liver. Twenty-four hours after the injection of galactosamine, cross-circulation was performed at a blood flow rate of 1 ml/min for 8 hours. Survival rate of the rats in 48 hours and 60 hours after the injection of galactosamine was 86% and 57% in a cross-circulation group and 66% and 23% in a sham-circulation group, respectively. In a cross-circulation group, there showed significant increases of ATP synthesis per 100 gr. body weight, turnover number of phosphorylation and Cyt a (+a3) which were markedly reduced in a sham-circulation group. These appear to suggest that cross-circulation provides augmented mitochondrial energy supply in the liver and contributes higher survival rate of the rats.
D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D003427:Cross Circulation / Q000379:methods*; D005688:Galactosamine; D008107:Liver Diseases / Q000628:therapy*; D008115:Liver Regeneration; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D010227:Parabiosis / Q000379:methods*; D051381:Rats; D011919:Rats, Inbred Strains
D005688:Galactosamine