title: The effects of acetylcholine on bulbar respiratory related neurones. Consequences of anaesthesia by pentobarbital.
abstract: The effects of cholinergic agonists and antagonists applied by microiontophoresis to bulbar respiratory neurones were determined in different preparations: cats anaesthetized by pentobarbital and immobilized by gallamine triethiodide, intercollicular decerebrate cats either not immobilized or immobilized by gallamine triethiodide. Respiratory neurones located at the bulbar level exhibited a muscarinic cholinergic sensitivity in all preparations. Muscarinic responses were either excitatory or inhibitory. The number of neurones showing excitatory responses was lower under pentobarbital anaesthesia than in decerebrate cats.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000771:Anesthesia, Intravenous; D000818:Animals; D002415:Cats; D003655:Decerebrate State; D005703:Gallamine Triethiodide / Q000494:pharmacology; D007103:Immobilization; D007478:Iontophoresis; D008526:Medulla Oblongata / Q000187:drug effects / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010276:Parasympatholytics / Q000494:pharmacology; D010277:Parasympathomimetics / Q000494:pharmacology; D010424:Pentobarbital / Q000494:pharmacology*; D010791:Phrenic Nerve / Q000502:physiology; D012125:Respiratory Center / Q000187:drug effects* / Q000502:physiology
chemical_list: D010276:Parasympatholytics; D010277:Parasympathomimetics; D010424:Pentobarbital; D000109:Acetylcholine; D005703:Gallamine Triethiodide