Antithrombotic activity of a glycosaminoglycan (sulodexide) in rats.
Glycosaminoglycans extracted from various sources are extensively utilized in the treatment of occlusive vascular disease. These products have shown to possess antithrombotic activity in some experimental thrombosis (1,2). Our purpose was to study the activity of Sulodexide, an heparin-like compound (3,4), on rat model of arterial thrombosis and to study its interaction with platelets.
D015104:3,4-Methylenedioxyamphetamine / Q000096:biosynthesis; D000818:Animals; D001241:Aspirin / Q000627:therapeutic use; D001792:Blood Platelets / Q000378:metabolism; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006025:Glycosaminoglycans / Q000627:therapeutic use*; D006493:Heparin / Q000627:therapeutic use; D000960:Hypolipidemic Agents / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013927:Thrombosis / Q000188:drug therapy
D005343:Fibrinolytic Agents; D006025:Glycosaminoglycans; D000960:Hypolipidemic Agents; D015104:3,4-Methylenedioxyamphetamine; C007858:glucuronyl glucosamine glycan sulfate; D006493:Heparin; D001241:Aspirin