Hyperplasia of antral G cells in uraemic patients.
In this study we have performed a quantitative analysis of antral gastrin cells in 9 uraemic patients under dialytic treatment compared to a group of 10 chronic gastritis patients with a similar histological degree of gastritis. Immunocytochemistry was carried out on endoscopic biopsies of both groups. Using a computerised image analysing system we showed a significant increase of G-cell density (number of cells/mm2) in uraemic patients compared to non-uraemics (p less than 0.001). These findings provide a further morphological basis for the elevation of gastrin levels in chronic uraemic patients, suggesting the existence of a specific factor inducing G-cell proliferation in these patients.
D000328:Adult; D002452:Cell Count; D002838:Chromaffin System / Q000473:pathology*; D004759:Enterochromaffin Cells / Q000473:pathology*; D005260:Female; D005757:Gastritis, Atrophic / Q000150:complications / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D011706:Pyloric Antrum / Q000473:pathology*; D006435:Renal Dialysis; D014511:Uremia / Q000150:complications*