Inbred mouse strain resistance to Mycobacterium lepraemurium follows the Ity/Lsh pattern.
Inbred mouse strains and their F1 hybrids infected intravenously with Mycobacterium lepraemurium showed different mean survival times (MST). BALB/c and C57BL mice were particularly susceptible, whereas C3H, CBA and DBA/2 mice were relatively resistant. Resistance as judged by MST was dominant in the F1 hybrids. A similar ranking order was obtained by comparing the doubling time of the bacillus in the bone marrow, the increase in spleen weight between 4 and 12 weeks after infection, and the pathology of the liver during infection. The general pattern suggests that mouse resistance to M. lepraemurium is, at least in part, controlled by a gene with the same strain distribution as the genes for resistance to Salmonella typhimurium (Ity') and Leishmania donovani (Lsh') and the gene controlling resistance to Mycobacterium bovis BCG (Bcg). Ity, Lsh and Bcg are all known to be on chromosome 1, suggesting a centre controlling reactions to intracellular infections.
D000818:Animals; D002455:Cell Division; D005260:Female; D005796:Genes; D007113:Immunity, Innate; D008099:Liver / Q000473:pathology; D051379:Mice; D008815:Mice, Inbred Strains; D009164:Mycobacterium Infections / Q000235:genetics / Q000276:immunology* / Q000401:mortality; D009167:Mycobacterium lepraemurium; D009929:Organ Size; D013154:Spleen / Q000473:pathology