title: [Effect of the neuroleptic fluphenazine dihydrochloride on the cardiovascular system of polytraumatized patients with an alcoholic anamnesis].
abstract: Haemodynamic effects in 10 multi-injured patients were registered after a bolus injection of 20 mg fluphenazin-dihydrochloride (Dapotum acutum; Fa. Heyden). Favourable results were seen in pre- and afterload. Parameters such as TTI, TTIB, CE and TI, characterising myocardial oxygen consumption, were also influenced positively. A reduction of mean arterial pressure can be avoided by administering slowly increasing volume and, occasionally, catecholamines. By use of modern monitoring in ICV, thus drug seems to be free from risk.
mesh_terms: D000328:Adult; D000430:Alcohol Withdrawal Delirium / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D005476:Fluphenazine / Q000009:adverse effects / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D010146:Pain / Q000188:drug therapy; D011604:Psychoses, Alcoholic / Q000188:drug therapy*; D014655:Vascular Resistance / Q000187:drug effects; D014947:Wounds and Injuries / Q000188:drug therapy*
chemical_list: D005476:Fluphenazine
vernacular_title: Die Wirkung des Neuroleptikums Fluphenazin-dihydrochlorid auf das Herz-Kreislaufsystem Polytraumatisierter mit Alkoholanamnese.