Age differences in the oxidation of and neural response to ethanol in mice.
Male mice (C57BL/6J) from three age groups, 4, 14, and 26 months, were tested to determine their oxidation rate of intragastrically infused ethanol and the response of the centrally mediated jaw-jerk reflex to ethanol challenge. There were no age-related differences in the rate of oxidation of ethanol. However, age differences in ethanol-induced decrement of the jaw-jerk amplitude were significant. The 26 month animals were the most affected, followed by the 4 month group. The middle aged mice (14 month) showed the greatest resistance to the depression induced by ethanol. The results were evaluated with regard to the current hypotheses.
D000367:Age Factors; D000818:Animals; D003864:Depression, Chemical; D000431:Ethanol / Q000378:metabolism* / Q000494:pharmacology; D008297:Male; D008636:Mesencephalon / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D010084:Oxidation-Reduction; D012018:Reflex / Q000187:drug effects*; D014276:Trigeminal Nerve / Q000187:drug effects
D000431:Ethanol