Lack of effect of domperidone on gastrin release: evidence for a peripheral activity of the drug.
The effect of intravenous administration of domperidone, a dopamine receptor antagonist with peripheral activity, on basal and submaximal pentagastrin-stimulated gastric acid secretion and gastrin release has been evaluated in healthy volunteers. No significant changes were observed in the parameters studied. The lack of effect on gastrin release appears to confirm that domperidone is unable to penetrate the blood brain barrier in appreciable amounts in adults.
D000328:Adult; D001812:Blood-Brain Barrier / Q000187:drug effects*; D004294:Domperidone / Q000494:pharmacology*; D018492:Dopamine Antagonists; D005260:Female; D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011954:Receptors, Dopamine / Q000187:drug effects
D018492:Dopamine Antagonists; D005755:Gastrins; D011954:Receptors, Dopamine; D004294:Domperidone