The alpha-form of S-adenosylmethionine synthetase isozymes from liver is principally functional.
Treatment of rats with an ethionine plus adenine or a methionine diet leads not only to a marked increase of the alpha-form isozyme of S-adenosylmethionine synthetase in liver, but also to the accumulation of comparable amounts of S-adenosylethionine and S-adenosylmethionine in liver. Transplantation of ascites tumor cells into mice leads to a marked increase only of the beta-form isozyme in the host liver, but the levels of S-adenosylmethionine do not significantly change in liver.
D000225:Adenine / Q000494:pharmacology; D000818:Animals; D004032:Diet; D005001:Ethionine / Q000494:pharmacology; D005260:Female; D007527:Isoenzymes / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008715:Methionine / Q000494:pharmacology; D008716:Methionine Adenosyltransferase / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014166:Transferases / Q000378:metabolism*
D007527:Isoenzymes; D008715:Methionine; D014166:Transferases; D008716:Methionine Adenosyltransferase; D000225:Adenine; D005001:Ethionine