title: [Antibiotic sensitivity of strains of Brucella].
abstract: The susceptibility of 31 strains of Brucella to various antibiotics was investigated by agar dilution technique. When tested with inocula ranging from 10(4) to 10(6) bacteria/ml, all strains were susceptible to tetracycline, chloramphenicol, streptomycin and gentamicin. More than 25% were resistant to the combination trimethoprim-sulfamethoxazole. With this combination, the maximal antibacterial effect was obtained at a trimethoprim/sulfamethoxazole ratio of 1:19. In 90% of the strains, stable mutants, highly resistant to rifampicin (CMI greater than or equal to 1024 micrograms/ml) were detected. The mutation rate was about 10-7.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002002:Brucella / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents
vernacular_title: Sensibilité aux antibiotiques de souches de Brucella.