title: [Effect of diets containing plant protein on liver mono-oxygenase activity in rats].
abstract: Male Wistar rats kept for 30 days on the diet containing vegetative (wheat) protein demonstrate an increase in cytochrome P-450 concentration in liver microsomes and an increase in the rate of amidopyrine N-demethylation and aniline p-hydroxylation. Administration of phenobarbital leads to cytochrome P-450 induction and activation of monooxygenase of rat liver microsomes, the quality of food protein not affecting cytochrome induction. It is assumed that high content of cytochrome P-450 is linked with prolongation of the time of cytochrome P-450 renewal at the expense of the decreased constant of its protein part degradation or with activation of cytochrome synthesis de novo (based on the preliminary data).
mesh_terms: D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis; D004044:Dietary Proteins / Q000008:administration & dosage*; D004789:Enzyme Activation; D004790:Enzyme Induction; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D008995:Monoamine Oxidase / Q000378:metabolism*; D010940:Plant Proteins / Q000008:administration & dosage*; D051381:Rats; D011919:Rats, Inbred Strains; D014908:Triticum
chemical_list: D004044:Dietary Proteins; D010940:Plant Proteins; D003577:Cytochrome P-450 Enzyme System; D000815:Aniline Hydroxylase; D008995:Monoamine Oxidase; D000633:Aminopyrine N-Demethylase; C019666:amidopyrine N-demethylase
vernacular_title: Vliianie ratsionov s rastitel'nym belkom na aktivnost' monooksigenaznoĭ sistemy pecheni krys.