Anti-C4 in the serum of a transfused C4-deficient patient with systemic lupus erythematosus.
A C4-deficient patient with systemic lupus erythematosus had been transfused on several occasions. His red cells reacted with a proportion of anti-Rg (Rodgers) and anti-Ch (Chido) reagents, but this was due to a separable antibody that did not have anti-Rg or anti-Ch specificity. Eluates of anti-Rg and anti-Ch indicate his red cell phenotype to be Rg-Ch-. Anti-C4 has been identified in his serum that exhibits neither anti-Rg nor anti-Ch specificity, but has similar serological characteristics in reacting with C4- and C4d-coated red cells.
D000328:Adult; D000918:Antibody Specificity; D001789:Blood Group Antigens / Q000276:immunology; D001803:Blood Transfusion; D003181:Complement C4 / Q000172:deficiency* / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007518:Isoantibodies; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000276:immunology*; D008297:Male
D001789:Blood Group Antigens; D003181:Complement C4; D007518:Isoantibodies