title: Distribution of 35S-taurine in rat neonates and adults. A whole-body autoradiographic study.
abstract: The distribution of 35S-taurine in rat neonates and adults was investigated by wholy -body autoradiography. The neonates (4-day-old) were frozen in dry-ice hexane at 30 min, 1, 3 and 6 h after an intraperitoneal injection of 35S-taurine, whereas survival intervals for adult rats were 1 and 3 h. Whole-sagittal sections of the frozen rat, obtained by using a cryostat microtome were dried in situ and autoradiographed. In rat neonates and adults, 35S-taurine was mainly accumulated in the renal cortex, urine, feces, liver, eye (lens, vitreous fluid, retina), hypophysis, thymus, adrenal glands, nasal mucous membrane, salivary glands, gastric mucosa, small and large intestinal mucosa, choroid plexus, myocardium and sebaceous glands. In the rat neonate, such regions as the olfactory bulb, cerebrum, and cerebellum showed relatively high optical density.
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001345:Autoradiography; D005260:Female; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013462:Sulfur Radioisotopes; D013654:Taurine / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D013462:Sulfur Radioisotopes; D013654:Taurine