Possible bioactive conformations of alpha-melanotropin.
By comparing the results of energy calculation for alpha-MSH and its semirigid analogues Ac-[ Cys4 , Cys10 ]-alpha- MSH4 -10-NH2, Ac-[ Cys4 , Cys10 ]-alpha- MSH4 -13-NH2, and [ Cys4 - Cys10 ]-alpha-MSH, a detailed description of two possible bioactive conformations for the 'specific' central site of alpha- MSH6 -9 is proposed representing variants of chain-reversal structure. A possible explanation of the rise in melanotropic activity of the latter two semirigid analogues is presented.
D009074:Melanocyte-Stimulating Hormones / Q000031:analogs & derivatives; D008968:Molecular Conformation; D013329:Structure-Activity Relationship; D013816:Thermodynamics
D009074:Melanocyte-Stimulating Hormones