The effects of the administration routes on the biliary excretion of antibiotics.
The effects of the administration routes on the biliary excretion of gentamicin and cefazolin were investigated in male white rabbits. The administration routes studied were intravenous, intramuscular injection and injection into portal vein. In both antibiotics, total excretion into bile was the highest when drug was administered by the injection into portal vein. In case of gentamicin, the bile level above MIC (against P.aeruginosa) could be obtained only by the administration into portal vein. These results indicate that the administration into portal vein is useful clinically, for the drug delivery to biliary tract, especially in drugs like aminoglycoside antibiotics which have an extremely low rate of transfer to the bile.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000378:metabolism*; D001646:Bile / Q000378:metabolism*; D002437:Cefazolin / Q000378:metabolism; D005839:Gentamicins / Q000378:metabolism; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D011817:Rabbits
D000900:Anti-Bacterial Agents; D005839:Gentamicins; C100093:gentamicin C; D002437:Cefazolin