Cancer treatment by methotrexate: rational use following pharmacokinetic study.
We used the test-dose method to calculate the dose of methotrexate to administer to the patients to reach the therapeutic but non-toxic blood concentration of 10(-5) mol/L. Methotrexate was tested with a radioimmunoassay technique and in 19 out of 20 patients we obtained the desired plateau during 24-h infusion.
D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D008727:Methotrexate / Q000008:administration & dosage* / Q000097:blood; D009369:Neoplasms / Q000188:drug therapy*; D011863:Radioimmunoassay
D008727:Methotrexate