Effects of angiotensins of the motility of human sperm.
The effects of angiotensins on the motility of highly washed human sperm were examined by multiple exposure photography system. The addition of low doses (0.1-10 ng/ml) of angiotensin II (AT II) stimulated the forward velocity of sperm without increasing the percentage of motility. On the contrary, high concentration (1.0 micrograms/ml) of AT II suppressed the motility. The direct effect of angiotensin I (AT I) on the motility was observed under the presence of SQ 14225, a specific inhibitor of angiotensin I converting enzyme (ACE). At I (0.1-100 ng/ml) gave no influence on the motility, whereas that of high dose (1.0 ug/ml) suppressed the motility in the same manner as the corresponding dose of AT II. The action of AT II on the motility was completely suppressed under the coexistence of saralasin, a specific antagonist against AT II. This fact indicated that the action of AT II on the sperm appeared through the specific receptor on sperm.
D000803:Angiotensin I / Q000494:pharmacology*; D000804:Angiotensin II / Q000494:pharmacology*; D000809:Angiotensins / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D012504:Saralasin / Q000494:pharmacology; D013081:Sperm Motility / Q000187:drug effects*
D000809:Angiotensins; D000804:Angiotensin II; D000803:Angiotensin I; D012504:Saralasin