Short oligodeoxynucleotides with d(G-C)n sequence do not assume left-handed conformation in high salt conditions.
d(G-C)n oligodeoxynucleotides (with n varying from 3 to 7) were studied by the circular dichroism technique in 5 M-NaCl. Contrary to what was previously found with the d(C-G)n series in the same solvent, the left-handed double-stranded Z-conformation appears less stable than the B-form for low n values. The influence of base sequence on the relative stability of B- and Z-conformations for the two series is discussed.
D001483:Base Sequence; D002942:Circular Dichroism; D003596:Cytosine; D006147:Guanine; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D009994:Osmolar Concentration
D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D006147:Guanine; D003596:Cytosine