title: The relaxant action of hymecromone and lignocaine on induced spasm of the bile duct sphincter.
abstract: The retained stone in the common bile duct remains a problem for the surgeon. Although more effective methods are available, mechanical flushing of the bile duct is, when successful, a simple solution. Pharmacological dilatation of the sphincter of Oddi is a logical adjunct to flushing. Pressure changes in the bile duct during flushing were studied in 20 postoperative patients with T-tube drains and the effectiveness of two drugs in reducing Omnopon induced spasm of the sphincter was compared. Hymecromone intravenously and lignocaine via the T-tube were equally effective, reducing sphincter activity in the majority of patients, but there was considerable individual variation.
mesh_terms: D000328:Adult; D000368:Aged; D014670:Ampulla of Vater / Q000187:drug effects*; D005260:Female; D006801:Humans; D006923:Hymecromone / Q000494:pharmacology*; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D008365:Manometry; D008875:Middle Aged; D009130:Muscle, Smooth / Q000187:drug effects; D010276:Parasympatholytics; D011312:Pressure; D011897:Random Allocation; D009803:Sphincter of Oddi / Q000187:drug effects* / Q000503:physiopathology; D014468:Umbelliferones / Q000494:pharmacology*
chemical_list: D010276:Parasympatholytics; D014468:Umbelliferones; D006923:Hymecromone; D008012:Lidocaine