Fatal intravascular immune hemolysis induced by hydrochlorothiazide.
A patient receiving antihypertensive therapy developed acute intravascular hemolysis and died. Hemolysis was due to an immune process associated with antibody to thiazide. Only two other cases have been reported. Thiazide-induced hemolysis appears to be confined to those patients treated concommitantly with methyldopa.
D000743:Anemia, Hemolytic / Q000139:chemically induced*; D000906:Antibodies / Q000032:analysis; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage / Q000009:adverse effects* / Q000276:immunology; D006973:Hypertension / Q000188:drug therapy; D008297:Male; D008750:Methyldopa / Q000008:administration & dosage / Q000627:therapeutic use; D008875:Middle Aged
D000906:Antibodies; D006852:Hydrochlorothiazide; D008750:Methyldopa