Analgesic activities of amphetamine isomers.
The analgesic activity of single doses of d- and l-amphetamine was tested in mice using four systems: 65 degrees C hot plate, 55 degrees C hot plate, tail flick, and acetic acid-induced writhing. Although both isomers had some activity, the l-isomer was generally more potent and had a greater duration of activity.
D000661:Amphetamine / Q000494:pharmacology*; D000700:Analgesics; D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects; D013237:Stereoisomerism; D013997:Time Factors
D000700:Analgesics; D000661:Amphetamine; D003913:Dextroamphetamine