[Local anesthetic properties of a polymeric compound of trimecaine].
Original techniques were used in experiments on rabbits and rats to explore the activity and duration of a local anesthetic action of a new trimecaine polymer as compared with trimecaine hydrochloride. The polymer effect was found to be 1.5-2 times longer as compared to that of its low-molecular analog, which was discovered in experimental terminal, conduction and infiltration anesthesia in particular. According to the data obtained, the prolongation of the effect of the new drug is determined by slow separation of trimecain from the polymer.
D000083:Acetanilides; D000779:Anesthetics, Local; D000818:Animals; D011108:Polymers; D011817:Rabbits; D051381:Rats; D013997:Time Factors; D014288:Trimecaine
D000083:Acetanilides; D000779:Anesthetics, Local; D011108:Polymers; D014288:Trimecaine
Mestoanesteziruiushchie svoĭstva polimernogo soedineniia trimekaina.