title: [Effect of perocin (zineb) on the quality of ovine seminal fluid].
abstract: The fungicide perocin , an analogue of the preparation Zineb ( ditiocarbamate ) was applied orally with the feed to 11 rams divided into two test groups of three animals each and one control group of five rams. The preparation was administered at the rate of 1/50 and 1/100 of DL50 per kg body mass to the first and second test group, respectively, in the course of 4 months. During both the preparatory and the experimental period semen was sampled twice a week with the use of an artificial vagina, and investigations were carried out to evaluate the qualitative properties of the semen, the level of Na ions, the redoxi -potential and the activity of the alkaline phosphatase (APh). Apparently, the preparation triggered a trend toward increasing the number of pathologic spermatozoa (20-30 per cent) and decreasing to a lower extent the concentration of the sodium ions and the values of the redoxi -potential. The motility of spermatozoa was lowered by 4.3 per cent for the animals that were treated with 1/50 DL50 per kg body mass, and by 2.1 per cent for those that were offered 1/100 DL50 per kg body mass. There were certain differences between the values obtained although these were statistically insignificant so far as the alkaline phosphatase was concerned. They pointed to the fact that perocin contributed to the increase in the value relationships of some of the forms of this enzyme. The same applied also to the APh1 which is believed to have certain bearing upon preserving the activity of spermatozoa.
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D004305:Dose-Response Relationship, Drug; D008297:Male; D010084:Oxidation-Reduction / Q000187:drug effects; D012661:Semen / Q000187:drug effects* / Q000201:enzymology; D012756:Sheep; D013094:Spermatozoa / Q000187:drug effects; D013859:Thiocarbamates / Q000494:pharmacology*; D013997:Time Factors; D015038:Zineb / Q000031:analogs & derivatives / Q000494:pharmacology*
chemical_list: D013859:Thiocarbamates; D000469:Alkaline Phosphatase; D015038:Zineb
vernacular_title: Vliianie na perotsina (tsineb) vurkhu kachestvata na ovcha semenna technost.