title: A model for transcriptional regulation based upon homology between introns and promoter regions and secondary structure in the promoter regions: the human globins.
abstract: Considerable homology was detected between promoter regions and introns of the same gene for each of the six genes in the human globin complex. In addition, homology between a promoter region of one gene and an intron of a second gene was observed. Each of the six genes also had extensive stem-loop structures in the promoter region. When the stretches of intron-promoter homology were compared to the regions involved in stem-loop structures, the two were found to be overlapping. It was hypothesized that the regulation of globin-switching in humans was accomplished by base pairing of intron transcripts with critical regions of the stem-loop structures. This hypothesis is consistent with all known facts regarding normal globin-switching.
mesh_terms: D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005246:Feedback; D005786:Gene Expression Regulation; D005914:Globins / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D009876:Operon; D011487:Protein Conformation; D014158:Transcription, Genetic
chemical_list: D005914:Globins; D004247:DNA