Reduction of daunorubicin aqueous solutions by COO.- free radicals. Reactions of reduced transients with H2O2.
Daunorubicin aqueous solutions were reduced by COO- free radicals produced by gamma-radiolysis. This reaction leads to 7-deoxyaglycon daunomycinone. Added before irradiation, H2O2 oxidized hydroquinone daunorubicin giving back the drug directly and thus preventing C-O bond cleavage. The implications of this reaction on the mechanism of the reductive cleavage are discussed.
D002264:Carboxylic Acids; D003630:Daunorubicin / Q000528:radiation effects; D005561:Formates; D005609:Free Radicals; D005720:Gamma Rays; D006861:Hydrogen Peroxide; D006873:Hydroquinones; D007700:Kinetics; D010084:Oxidation-Reduction
D002264:Carboxylic Acids; D005561:Formates; D005609:Free Radicals; D006873:Hydroquinones; C030544:formic acid; D006861:Hydrogen Peroxide; D003630:Daunorubicin