Brain state and kindled seizures.
Interaction between "level of activation" and kindled seizures was studied in two experiments. In the first experiment rats kindled while showing locomotor activity were slower in developing kindled seizures than rats kindled while inactive. In the second experiment three groups of rats received different footshock pretreatment during the acquisition phase of kindling. Footshock 30 min before stimulation caused more intense and longer lasting seizures. Crossover of experimental treatment conditions between groups suggested a state dependency of the kindled seizures. We concluded that there are complex relationships between activation and kindled seizures.
D000818:Animals; D001143:Arousal / Q000502:physiology; D001921:Brain / Q000502:physiology*; D004597:Electroshock; D007696:Kindling, Neurologic; D008297:Male; D009043:Motor Activity / Q000502:physiology; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000503:physiopathology*