title: Pleiotropic overdominance and the maintenance of genetic variation in polygenic characters.
abstract: A model of selection is described in which optimizing phenotypic selection is combined with pleiotropic overdominance. Thus, the role that mutation commonly plays in models of phenotypic evolution is replaced by balancing selection. Expressions are provided for the equilibrium genetic variance in phenotype and for the heterozygosity. An approximate analysis of the transient properties of the model shows that, in certain circumstances, the behavior is quite similar to that of models based on the interaction of mutation and selection.
mesh_terms: D005799:Genes, Dominant; D014644:Genetic Variation; D008433:Mathematics; D008957:Models, Genetic; D010641:Phenotype; D012641:Selection, Genetic