[Effect of the intravenous administration of homologous albumin on the lipolytic enzyme activity of rabbit blood plasma].
Activity of main lipolytic enzymes of rabbit blood plasma, lipoprotein lipase (LPL) and liver tissue triglyceride lipase (L-TGL) as well as intensity of lipoprotein lipolysis in vivo, which was estimated by an increase of unesterified fatty acids in blood plasma, studied after intravenous administration of homologous albumin at a dose of 200 mg/kg of body mass. The data obtained suggest that albumin is involved in regulation of lipoprotein lipolysis due to activation of LPL, caused by asseption of unesterified fatty acids, which are liberated after hydrolysis of triglycerides. This effect was exhibited by albumin only under conditions of active stimulation of lipolytic reactions, it occurs after intravenous administration of heparin (100 IU/kg of body mass). Albumin did not activate lipoprotein lipolysis and lipolytic enzymes in intact animals. Activity of L-TGL in blood plasma was less distinctly subjected to the regulatory effect of albumin.
D000418:Albumins / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002784:Cholesterol / Q000097:blood; D004338:Drug Combinations; D004591:Electrophoresis, Polyacrylamide Gel; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D006493:Heparin / Q000008:administration & dosage / Q000494:pharmacology; D007275:Injections, Intravenous; D008049:Lipase / Q000097:blood*; D008071:Lipoprotein Lipase / Q000097:blood*; D008079:Lipoproteins, VLDL / Q000097:blood; D008099:Liver / Q000201:enzymology; D008297:Male; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
D000418:Albumins; D004338:Drug Combinations; D005230:Fatty Acids, Nonesterified; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D006493:Heparin; D002784:Cholesterol; D008049:Lipase; D008071:Lipoprotein Lipase
Vliianie vnutrivennogo vvedeniia gomologichnogo al'bumina na aktivnost' lipoliticheskikh fermentov plazmy krovi krolika.