title: Dopaminergic efferent inhibition of carotid body chemoreceptors in chronically hypoxic cats.
abstract: The observations that the dopamine concentration of the carotid body and efferent inhibition of carotid chemoreceptors are increased during chronic hypoxia led to the hypothesis that the inhibition was due to the effect of an increased dopamine release by the activity of carotid sinus nerve (CSN) efferents. The hypothesis was tested by measuring the effect of dopamine receptor blockade on efferent inhibition of carotid chemosensory responses to graded levels of arterial O2 partial pressure in chronically hypoxic and normoxic cats. Chronically hypoxic cats were prepared by exposing the cats to 10% O2 at sea level for 30-34 days. Carotid chemosensory activity was first measured from a slip of an otherwise intact CSN. The measurements were then repeated after sectioning the remaining nerve trunk. The effect of sectioning the CSN provided the measure of efferent inhibition. In each group of cats the effects of sectioning the CSN with and without dopamine receptor blockade by haloperidol were also studied. CSN section augmented the chemosensory responses in the chronically hypoxic cats. Haloperidol, a dopamine antagonist, augmented the responses further, indicating that a part of the endogenous dopamine effect was independent of the CSN efferents. After haloperidol treatment CSN section did not influence the chemosensory responses. This study confirmed that the efferent inhibition significantly increased in the chronically hypoxic cats and demonstrated that haloperidol blocked the efferent inhibition, suggesting that the mechanism of the augmented inhibition is dopaminergic.
mesh_terms: D000818:Animals; D002344:Carotid Body / Q000187:drug effects / Q000502:physiology*; D002346:Carotid Sinus / Q000294:innervation*; D002415:Cats; D004525:Efferent Pathways / Q000187:drug effects / Q000502:physiology*; D005246:Feedback; D006220:Haloperidol / Q000494:pharmacology; D000860:Hypoxia / Q000503:physiopathology*; D010100:Oxygen / Q000502:physiology; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*
chemical_list: D011954:Receptors, Dopamine; D006220:Haloperidol; D010100:Oxygen