[Radiosensitive mutants of yeast-Saccharomyces with disruptions in the cell division cycle. Cell inactivation by restrictive temperature, ultra-violet and ionizing radiation in relation to the passage of the generated cycle].
Three thermo- and radiosensitive mutants of yeast-Saccharomyces were used to study cell inactivation under the effect of elevated temperature, UV-light, and ionizing radiation. The forms of cell inactivation were shown to be identical with all the factors under study and to resemble lethal "terminal phenotypes" of Hartwell cds mutants. It is suggested that the cell division cycle is blocked due to the disorders in the system of gene product synthesis and not to defects in the enzymes themselves.
D002455:Cell Division / Q000528:radiation effects*; D005720:Gamma Rays; D009154:Mutation; D011836:Radiation Tolerance; D011839:Radiation, Ionizing; D012440:Saccharomyces / Q000528:radiation effects*; D013696:Temperature; D014466:Ultraviolet Rays
Radiochuvstvitel'nye mutanty drozhzheĭ-Sakharomitsetov s narusheniiami tsikla kletochnogo deleniia. Inaktivatsiia kletok restriktivnoĭ i ioniziruiushcheĭ radiatsieĭ v zavisimosti ot prokhozhdeniia generatsionnogo tsikla.