title: A comparison of the effect of tiamulin hydrogen fumarate and tylosin tartrate on mycoplasmas of ruminants and some animal ureaplasmas.
abstract: The in vitro efficacy of tiamulin was compared to that of tylosin against 7 bovine, 7 ovine and 3 caprine mycoplasma strains isolated from various organs and belonging to different species, as well as 7 ureaplasma strains cultured from cattle, sheep, swine, chickens and turkeys. The minimal mycoplasmacidal concentrations of tiamulin varied between 0.01 and 10.0 micrograms ml-1, while tylosin proved to be active in concentrations of 0.5 and 100.0 micrograms ml-1. Five of 17 mycoplasma strains showed identical sensitivities to both antibiotics while all other strains, including the ureaplasmas, were sensitive to tiamulin at concentrations 5-5000-times lower than tylosin.
mesh_terms: D000818:Animals; D000829:Animals, Domestic / Q000382:microbiology*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002417:Cattle; D002645:Chickens; D004224:Diterpenes / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D005260:Female; D006041:Goats; D007933:Leucomycins / Q000494:pharmacology*; D008297:Male; D009174:Mycoplasma / Q000187:drug effects*; D012756:Sheep; D013045:Species Specificity; D013552:Swine; D014422:Turkeys; D015645:Tylosin; D014509:Ureaplasma / Q000187:drug effects*
chemical_list: D000900:Anti-Bacterial Agents; D004224:Diterpenes; D007933:Leucomycins; C014224:tiamulin; D015645:Tylosin