Alkylation of urinary guanine in mice by the organophosphorus insecticide tetrachlorvinphos.
The methylating capability of tetrachlorvinphos on urinary guanine in mice has been investigated using an insecticide labeled at both O-CH3 groups. Following intraperitoneal administration of the 14C-labeled insecticide to mice, about 0.57% of the radioactivity in the O- to 24-hr samples was associated with the purine fraction. The amount of [7-14C]methylguanine in 0- to 48-hr urine samples, estimated as fraction of applied dose, was 26-31 X 10(-5). The results obtained indicate possible chemical alkylation of urinary guanine. On the other hand, a considerable portion of radioactivity is probably incorporated via the C-1 pool.
D000478:Alkylation; D000818:Animals; D006147:Guanine / Q000378:metabolism / Q000652:urine*; D008297:Male; D051379:Mice; D013751:Tetrachlorvinphos / Q000494:pharmacology* / Q000652:urine
D006147:Guanine; D013751:Tetrachlorvinphos