Local anti-fertility effect of inhibin-enriched preparation (IEP) in female hamsters.
An inhibin-enriched preparation (IEP) involved in the regulation of follicle stimulating hormone (FSH) is known to play an important role in the normal ovarian cycle. In utero administration of 10 micrograms of IEP on day 3 of pregnancy completely prevented implantation in hamsters. No toxic effect of IEP was observed on the blastocysts as indicated by the dye exclusion test performed with Trypan blue. Thus, the results of the present study indicate an extra-pituitary site of action for the anti-implantation effect of IEP.
D000818:Animals; D001755:Blastocyst / Q000166:cytology; D002470:Cell Survival / Q000187:drug effects; D003281:Contraceptives, Postcoital / Q000494:pharmacology*; D006224:Cricetinae; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D007265:Inhibins / Q000494:pharmacology*; D008647:Mesocricetus; D011247:Pregnancy
D003281:Contraceptives, Postcoital; D007265:Inhibins