Advantages of adding a course of tetracycline to single dose ampicillin and probenecid in the treatment of gonorrhoea.
Chlamydia trachomatis was reisolated from 11 of 12 men with gonorrhoea who had initially yielded chlamydiae and who had been treated with ampicillin and probenecid (AMP) only, but from none of five such men treated with ampicillin and probenecid followed by tetracycline (AMPT). These results correlated with the absence of postgonococcal urethritis (PGU) in the group treated with AMPT. C trachomatis was isolated or reisolated from 20 of 25 women after treatment with AMP, compared with none of 14 women treated with AMPT. We recommend the addition of a course of tetracycline to the routine single dose treatment for gonorrhoea in men and women.
D000667:Ampicillin / Q000627:therapeutic use*; D002690:Chlamydia Infections / Q000188:drug therapy; D002692:Chlamydia trachomatis; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D010118:Oxytetracycline / Q000627:therapeutic use*; D011339:Probenecid / Q000627:therapeutic use*; D014526:Urethritis / Q000517:prevention & control
D004338:Drug Combinations; D000667:Ampicillin; D011339:Probenecid; D010118:Oxytetracycline