Acute hepatic injury associated with minocycline.
Minocycline hydrochloride hepatotoxic effect occurred in one patient. Unlike the usual histologic features of tetracycline-induced hepatic injury, fatty metamorphosis was predominantly macrovesicular . The patient recovered when drug therapy was withdrawn. Close observation of liver function variables is recommended in patients treated with high parenteral doses of minocycline, particularly in cases of pregnancy or renal disease.
D000208:Acute Disease; D056486:Chemical and Drug Induced Liver Injury; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology; D008875:Middle Aged; D008911:Minocycline / Q000009:adverse effects*; D013754:Tetracyclines / Q000009:adverse effects*
D013754:Tetracyclines; D008911:Minocycline