title: Tc-99m glucoheptonate estimation of glomerular filtration rate. Correlation with endogenous creatinine clearance.
abstract: Estimation of GFR using radioisotope techniques has been successfully accomplished with I-125 iothalamate, Cr-51 EDTA, and Tc-99m DTPA. However, the techniques have required up to several hours to complete with blood and/or urine sampling. A method introduced by Schlegel and modified by Gates provides a simple and rapid technique of GFR quantitation that obviates the need for blood and urine sampling. In the present study an evaluation of Tc-99m GHA was undertaken to assess its ability to reflect GRF using a modification of Gates' technique. When the GFR determinations were compared with a current 24-hour CrC1, a correlation coefficient of 0.91 was obtained. Tc-99m GHA-derived GFR appears to closely correlate with endogenous CrC1 over a wide range of renal function.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D003404:Creatinine / Q000097:blood*; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011866:Radioisotope Renography / Q000379:methods; D013400:Sugar Acids; D013667:Technetium
chemical_list: D015609:Organotechnetium Compounds; D013400:Sugar Acids; D013667:Technetium; D003404:Creatinine; C100014:technetium Tc 99m gluceptate