Relationship between cerebral blood volume and CSF pressure during anesthesia with isoflurane or fentanyl in dogs.
Cerebral blood volume (CBV) and intracranial (ICP) were examined in dogs during 3.5 h anesthesia with isoflurane (1.4% expired) or fentanyl (continuous intravenous infusion), and after decreasing the concentration of isoflurane to less than 0.15% expired or discontinuing administration of fentanyl. Isoflurane (1.4%) increased CBV 9-11% for greater than 3 h but increased ICP for only the first 21.7 +/- 1.4 min (mean +/- SEM). Fentanyl decreased CBV 7-10% for greater than 3 h but decreased ICP for only the first 20.3 +/- 2.7 min. Because both halothane or enflurane increase ICP for greater than 3 h in this model, both isoflurane or fentanyl may be preferred to halothane or enflurane for patients at risk for increased ICP.
D000758:Anesthesia; D000818:Animals; D001784:Blood Gas Analysis; D001921:Brain / Q000098:blood supply* / Q000187:drug effects; D004285:Dogs; D005283:Fentanyl / Q000494:pharmacology*; D007427:Intracranial Pressure / Q000187:drug effects*; D007530:Isoflurane / Q000494:pharmacology*; D008738:Methyl Ethers / Q000494:pharmacology*
D008738:Methyl Ethers; D007530:Isoflurane; D005283:Fentanyl