A model for the synthesis of chemical compounds in red blood cells, with an application to diabetes.
The amount of a substance produced and stored in red blood cells is modelled as the solution to a first-order differential equation involving the stochastic rate of production of the substance within each cell, the lifespans of the cells, and the birth and death rates of the cells. Estimation of the parameters of the model is outlined for a special case, and the model is fitted to a set of real data taken from clinically diabetic dogs.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000097:blood* / Q000378:metabolism; D004285:Dogs; D004905:Erythrocyte Aging; D004912:Erythrocytes / Q000378:metabolism*; D006442:Glycated Hemoglobin / Q000031:analogs & derivatives / Q000096:biosynthesis; D008954:Models, Biological
D006442:Glycated Hemoglobin; C025617:glucosylated hemoglobin A