Inhibition of thymidylate synthetase by the new quinazoline antifolate, CB 3717; enzyme purification and kinetics.
D000818:Animals; D005492:Folic Acid / Q000031:analogs & derivatives*; D005493:Folic Acid Antagonists / Q000494:pharmacology*; D007700:Kinetics; D007939:Leukemia L1210 / Q000201:enzymology*; D008780:Methyltransferases / Q000037:antagonists & inhibitors*; D051379:Mice; D011799:Quinazolines / Q000494:pharmacology*; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors* / Q000302:isolation & purification
D005493:Folic Acid Antagonists; D011799:Quinazolines; C031662:CB 3717; D005492:Folic Acid; D008780:Methyltransferases; D013940:Thymidylate Synthase