title: Tritiation of vasopressin analogues and their metabolic fate after intravenous injection in the rat.
abstract: Tritiated vasopressin analogues (LVP, AVP, dDAVP) of high specific activity were produced. The labelled peptides were purified by RP-HPLC. The biological half-life, organ distribution and in vivo metabolism of the hormones were studied in the rat. The half-life of dDAVP was longer than that of LVP or AVP. The half-life calculated from [3H]AVP isolated from bloods was shorter than the value based on total radioactivity. The hormones were degraded in the kidney, the liver and small intestine, the main metabolic product being [3H]Tyr. Large radioactivity accumulations were detected in the neurohypophysis and the adenohypophysis.
mesh_terms: D000818:Animals; D001127:Arginine Vasopressin / Q000097:blood / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003894:Deamino Arginine Vasopressin / Q000097:blood / Q000378:metabolism*; D006207:Half-Life; D007421:Intestine, Small / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008236:Lypressin / Q000097:blood / Q000378:metabolism*; D008297:Male; D051381:Rats; D014018:Tissue Distribution; D014316:Tritium
chemical_list: D014316:Tritium; D001127:Arginine Vasopressin; D008236:Lypressin; D003894:Deamino Arginine Vasopressin