Effects of D-penicillamine on inflammatory and immune reactions.
The effects of D-penicillamine (D-Pen) in rheumatoid arthritis suggest that the drug may be anti-inflammatory and immunosuppressive. Paradoxically D-Pen therapy may also induce antibody formation, and autoimmune disease. D-Pen is not consistently effective in animal models of immune disease. It is weakly suppressive in cellular responses to mitogens, but has a more pronounced effect on macrophage-dependent mixed leukocyte responses. The drug has an inconsistent effect on various components of the inflammatory reaction but under certain circumstances inhibits oxygen radical generation by monocyte/macrophages.
D000917:Antibody Formation / Q000187:drug effects*; D000936:Antigen-Antibody Complex / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D010396:Penicillamine / Q000627:therapeutic use*; D012217:Rheumatoid Factor / Q000032:analysis
D000936:Antigen-Antibody Complex; D001323:Autoantibodies; D012217:Rheumatoid Factor; D010396:Penicillamine