Cure of Trypanosoma musculi infection by heat-labile activity in immune plasma.
Passive transfer of plasma from a mouse cured of parasitemia to a Trypanosoma musculi-infected host rapidly eliminates parasitemia; this curative activity, presumably mediated by an immunoglobulin, is sensitive to heat treatment (56 degrees C, 30 min). In addition, pretreatment with immune plasma, even after heat treatment, prevents the development of a patent parasitemia in a naive host (protective activity).
D000818:Animals; D006358:Hot Temperature; D007106:Immune Sera; D007116:Immunization, Passive; D007167:Immunotherapy; D051379:Mice; D008810:Mice, Inbred C57BL; D014352:Trypanosomiasis / Q000628:therapy*
D007106:Immune Sera