Quinazoline CB 3717 and CB 3703 inhibition of folate retention and metabolism in Ehrlich ascites carcinoma cells and some organs of the host-mouse.
Disturbances in folate metabolism in Ehrlich ascites carcinoma-bearing mice caused by 2 quinazoline-antifolates are described. They are manifested by diminished retention in tumour cells and the host-liver of injected radioactive folate and by a decreased extent of its conversion to coenzymatic, polyglutamate forms. Kidney retention of folate was also affected by either quinazoline, showing a severalfold decrease in mice treated with CB 3703, and a 2-fold increase in those treated with CB 3717. Kidney folylpolyglutamate content was also greatly reduced.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D005260:Female; D005492:Folic Acid / Q000378:metabolism* / Q000031:analogs & derivatives; D005493:Folic Acid Antagonists / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D011799:Quinazolines / Q000494:pharmacology*
D005493:Folic Acid Antagonists; D011799:Quinazolines; C025927:CB 3703; C031662:CB 3717; D005492:Folic Acid