Plasma catecholamine concentrations. The effects of infiltration with local analgesics and vasoconstrictors during nasal operations.
Plasma catecholamine concentrations were measured in 19 patients allocated randomly to receive submucous infiltration with 4 ml of either 0.5% lignocaine with adrenaline 1:200 000 or prilocaine 0.5% with octapressin 0.03 iu per ml. Venous blood samples were obtained before and at 2, 5, and 10 minutes following infiltration. Plasma adrenaline increased from 0.35 to 1.72 p mol/ml at 2 minutes infiltration with the former solution whilst there was little change in plasma noradrenaline concentration. No similar peak in adrenaline concentration occurred after infiltration with prilocaine/ octapressin solutions but with both solutions there was a small increase in plasma noradrenaline and adrenaline concentrations 10 minutes after infiltration, at the time of surgical stimulation.
D000293:Adolescent; D000328:Adult; D000772:Anesthesia, Local; D004837:Epinephrine / Q000097:blood*; D005259:Felypressin; D005260:Female; D006801:Humans; D008012:Lidocaine; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood*; D009666:Nose / Q000601:surgery*; D011318:Prilocaine; D011897:Random Allocation; D013997:Time Factors
D011318:Prilocaine; D005259:Felypressin; D008012:Lidocaine; D009638:Norepinephrine; D004837:Epinephrine