A multicenter clinical study of cefoperazone.
Thirty-five adult and 11 pediatric patients in nine Philippine hospitals were treated with cefoperazone for various moderate to severe infections. Adults received 1 to 8 gm/day and children received 0.450 to 4 gm/day in two divided doses, for a mean period of eight to nine days (ranges, 5 to 11 days for children and 5 to 30 days for adults). The efficacy rate (cured and improved) was 90.90% for pediatric patients and 85.72% for adult patients. In a group of patients shifted from other antibiotic regimens, efficacy rates were 100% for pediatric patients and 85% for adult patients treated with cefoperazone. No follow-up cultures were obtained from patients from whom 26 pathogens were isolated, but correlations between the isolates and clinical efficacy showed that cefoperazone had an efficacy rate of 92.3%.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000188:drug therapy*; D002438:Cefoperazone / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D010538:Peritonitis / Q000188:drug therapy; D011014:Pneumonia / Q000188:drug therapy; D012874:Skin Diseases, Infectious / Q000188:drug therapy
D002438:Cefoperazone