title: Effect of cupric chloride on oxidative metabolism in the freshwater teleost, Tilapia mossambica.
abstract: The freshwater teleost Tilapia mossambica was subjected to lethal (6.0 mg X liter-1 = LC50/48 hr) and sublethal (1.5 mg X liter-1 copper treatment for 1, 7, and 14 days. The whole animal oxygen consumption and the activity levels of succinate dehydrogenase and lactate dehydrogenase in liver and muscle were studied. The decrease in oxygen consumption and succinate dehydrogenase activity and significant increase in lactate dehydrogenase activity suggest that the stressed fish is meeting its energy requirements through anaerobic oxidation and these enzymes can be used as indicators in monitoring metal-induced toxicity in fish.
mesh_terms: D000818:Animals; D003300:Copper / Q000633:toxicity*; D005399:Fishes / Q000378:metabolism*; D005618:Fresh Water; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D007928:Lethal Dose 50; D008099:Liver / Q000201:enzymology / Q000378:metabolism; D009132:Muscles / Q000201:enzymology / Q000378:metabolism; D010084:Oxidation-Reduction; D010101:Oxygen Consumption / Q000187:drug effects*; D013385:Succinate Dehydrogenase / Q000378:metabolism
chemical_list: D003300:Copper; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; C029892:cupric chloride