Failure of the biguanide moroxydine chloride to stimulate plasma fibrinolytic activity.
Eleven patients with recurrent venous thrombosis or thrombophlebitis and a decreased fibrinolytic activity after venous occlusion were given a phenformin-like substance, moroxydine chloride, for 6 months. No sustained increase in the fibrinolytic activity was observed after moroxydine treatment.
D000328:Adult; D000368:Aged; D001645:Biguanides; D004341:Drug Evaluation; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000494:pharmacology*; D010629:Phenformin / Q000494:pharmacology; D012008:Recurrence; D013607:Tablets; D013924:Thrombophlebitis / Q000097:blood / Q000188:drug therapy*
D001645:Biguanides; D009025:Morpholines; D013607:Tablets; D010629:Phenformin; C005267:moroxydine