[Clinico-electrophysiologic study of the anti-arrhythmic action of trimecaine].
The antiarrhythmic activity of trimecaine hydrochloride administered orally and intramuscularly was studied in 58 patients with coronary heart disease accompanied by ventricular and supraventricular rhythm disorders. In 73.9% of the cases the drug exhibited antiarrhythmic action which was reflected in a longer period of the recovery of sinus node function, inhibited conduction in the atrioventricular node and a decreased time of intraatrial conduction. Side effects were observed in 17.3% of the cases mostly with the oral drug; they tended to abate spontaneously 2-4 h after trimecaine hydrochloride withdrawal.
D000083:Acetanilides / Q000627:therapeutic use*; D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D003327:Coronary Disease / Q000150:complications; D004562:Electrocardiography; D006801:Humans; D007273:Injections, Intramuscular; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications; D014288:Trimecaine / Q000008:administration & dosage / Q000627:therapeutic use*
D000083:Acetanilides; D014288:Trimecaine
Kliniko-élektrofiziologicheskoe izuchenie antiaritmicheskogo deĭstviia trimekaina.