title: Blood leakage and melphalan leakage from the perfusion circuit during regional hyperthermic perfusion for malignant melanoma.
abstract: In regional hyperthermic perfusion with melphalan for patients with malignant melanoma of the leg, plasma leakage between the perfusion circuit and the systemic circulation was 4-7 ml X min-1. The melphalan concentration in the perfusate was biphasic, with half-lives of 8-12 mins for the initial phase and 19-28 mins for the second phase, after the first dose. After a second dose, the corresponding values were 11-13 and 26-34 mins. The highest concentration in general circulation was 0.38 micrograms X ml-1.
mesh_terms: D010478:Chemotherapy, Cancer, Regional Perfusion / Q000009:adverse effects / Q000379:methods*; D003131:Combined Modality Therapy; D006207:Half-Life; D006801:Humans; D006979:Hyperthermia, Induced; D007457:Iodine Radioisotopes / Q000097:blood; D007866:Leg; D008545:Melanoma / Q000097:blood / Q000188:drug therapy*; D008558:Melphalan / Q000008:administration & dosage* / Q000097:blood
chemical_list: D007457:Iodine Radioisotopes; D008558:Melphalan