title: Inhibition of mRNA synthesis in rabbit bone marrow nuclei in vitro by quinone metabolites of benzene.
abstract: mRNA synthesis by rabbit bone marrow nuclei has been shown to be inhibited by the quinone metabolites of benzene, hydroquinone and p-benzoquinone, in a concentration-dependent manner with 50% inhibitory concentration (IC50[M]) for both compounds of 6 X 10(-6) M. Catechol and 1,2,4-benzenetriol also showed a concentration-dependent inhibition of synthesis, however, 50% inhibition was not reached by 10(-4) M. Phenol did not inhibit mRNA synthesis even at 10(-3) M. It is possible that myelotoxicity from benzene might result from such an inhibition of mRNA synthesis by quinone metabolites in pluripotent and/or committed bone marrow stem cells.
mesh_terms: D000818:Animals; D016227:Benzoquinones; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism*; D002396:Catechols / Q000494:pharmacology; D002467:Cell Nucleus / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006873:Hydroquinones / Q000494:pharmacology*; D008297:Male; D011809:Quinones / Q000494:pharmacology*; D012333:RNA, Messenger / Q000096:biosynthesis*; D011817:Rabbits; D014544:Uridine Triphosphate / Q000378:metabolism
chemical_list: D016227:Benzoquinones; D002396:Catechols; D006873:Hydroquinones; D011809:Quinones; D012333:RNA, Messenger; C013038:hydroxyhydroquinone; C004532:quinone; C034221:catechol; D014544:Uridine Triphosphate; C031927:hydroquinone