[Effect of nonachlazine on the size of an experimental myocardial infarct].
The effect of intravenous injection of nonachlazine on the infarction size in rabbits was studied planimetrically 7 days after coronary artery occlusion. The first group rabbits received the drug 5 times every 30 minutes, beginning from the 30th minute after occlusion (the total dose 15 mg/kg). The second group rabbits were given nonachlazine 3 times a day (the total dose 12 mg/kg) during 6 days, beginning from the 2nd day after coronary artery occlusion. In both the animal groups, the drug induced respectively a 22.8 and 39.4% decrease in the necrosis size as compared to control. The effect of nonachlazine is presumably linked with stimulation of the collateral coronary circulation in the occluded zone and with the drug direct action on myocardial metabolism.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects; D008297:Male; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009336:Necrosis; D009628:Nonachlazine / Q000008:administration & dosage*; D010640:Phenothiazines / Q000008:administration & dosage*; D011817:Rabbits; D013997:Time Factors
D010640:Phenothiazines; D009628:Nonachlazine
Vliianie nonakhlazina na razmery éksperimental'nogo infarkta miokarda.