[Chemotherapeutic effectiveness of gentamycin, tobramycin and sisomycin in Pseudomonas aeruginosa pyelonephritis in rats compared with dioxidine].
The chemotherapeutic efficacy of gentamicin, tobramycin, sisomicin and dioxydin was studied and compared in rats with hematogenic obturation P. aeruginosa pyelonephritis. The drugs were injected intramuscularly in doses of 5, 8, 8 and 50 mg/kg, respectively for 7 days a day after infection. It was shown that on prolongation of the period of the treatment estimation from 24 hours to 7 days after discontinuation of the drug use a significant decrease was observed in the therapeutic efficacy of dioxydin, gentamicin and especially tobramycin. As for sisomicin, the decrease was insignificant. Dioxydin and gentamicin had a similar therapeutic effect at the early and late periods of their estimation after discontinuation of the treatment. They were inferior to tobramycin with respect to the early results and superior to it with respect to the late results. The chemotherapeutic efficacy of sisomycin in both the cases was higher than that of tobramycin, gentamicin and dioxydin.
D000818:Animals; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use*; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011704:Pyelonephritis / Q000188:drug therapy*; D011810:Quinoxalines / Q000627:therapeutic use*; D051381:Rats; D012853:Sisomicin / Q000627:therapeutic use*; D013997:Time Factors; D014031:Tobramycin / Q000627:therapeutic use*
D000890:Anti-Infective Agents; D005839:Gentamicins; D011810:Quinoxalines; C001077:dioxidine; D014031:Tobramycin; D012853:Sisomicin
Izuchenie khimioterapevticheskoĭ éffektivnosti gentamitsina, tobramitsina i sizomitsina pri sinegnoĭnom pielonefrite u krys v sravnenii s dioksidinom.