title: Mast cells and eosinophils in the jejunal mucosa of patients with intestinal cow's milk allergy and celiac disease of childhood.
abstract: We counted the number of granulated mast cells with high iron diamine staining, and the number of eosinophils with hematoxyline-eosin staining, in the lamina propria of the jejunum in 12 untreated patients with intestinal cow's milk allergy (CMA), 47 with celiac disease (CD), and 14 controls. A decreased number of mast cells and an increased number of eosinophils were found in 58% of patients with CMA, and in 60% of those with CD. The number of mast cells showed a significant positive correlation with the villous height, and the number of eosinophils a negative correlation with both the villous height, and the number of mast cells. Appropriate dietary treatment resulted in a rise in the number of granulated mast cells and a decrease in the number of eosinophils in both patient groups.
mesh_terms: D000293:Adolescent; D001706:Biopsy; D002446:Celiac Disease / Q000178:diet therapy / Q000473:pathology*; D002452:Cell Count; D002648:Child; D002675:Child, Preschool; D004804:Eosinophils / Q000473:pathology*; D006801:Humans; D007223:Infant; D007413:Intestinal Mucosa / Q000473:pathology*; D007583:Jejunum / Q000473:pathology*; D007787:Lactose Intolerance / Q000178:diet therapy / Q000473:pathology*; D008286:Malabsorption Syndromes / Q000178:diet therapy / Q000473:pathology; D008407:Mast Cells / Q000473:pathology*