Protective effect of metoprolol on emetine induced T wave changes in animals.
We studied the protective effect of metoprolol on emetine induced T wave changes in rabbits. None of the rabbits who were beta-blocked before administration of emetine develop the T wave changes observed consistently in the control group. These observations support our clinical impression that emetine-induced T wave changes are produced because of stimulation of peripheral sympathetic nervous system and can be effectively prevented by prior and concomitant beta-blockade.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control*; D004562:Electrocardiography; D004640:Emetine; D008790:Metoprolol / Q000494:pharmacology*; D011817:Rabbits
D008790:Metoprolol; D004640:Emetine