title: Further observations on spermiophagy by murine peritoneal macrophages in vitro.
abstract: Resident mouse peritoneal macrophages when maintained in cell culture phagocytosed and degraded homologous epididymal spermatozoa. The acrosome and its associated antigens were readily degraded, showing degenerative changes within minutes of spermiophagy and being completely destroyed by 1 h. Other components of the spermatozoon were more resistant and fragments of nuclear material and tail axial filaments could still be recognized within some macrophages up to 7 days after phagocytosis. The findings may be relevant to the disposal of spermatozoa in the genital tract in vivo.
mesh_terms: D000818:Animals; D001202:Ascitic Fluid; D002478:Cells, Cultured; D008264:Macrophages / Q000502:physiology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence; D010587:Phagocytosis; D013094:Spermatozoa