title: [Immunoprevention of hepatitis B in children].
abstract: Perinatal transmission of hepatitis B virus does not occur before the beginning of labor. Therefore, neither an embryopathy nor a fetopathy appears to be caused by an acute or chronic HBV infection during pregnancy. There is no necessity to interrupt pregnancy for the reason of a HBV infection. Transmission of HBV infection, however, may take place during delivery. By simultaneous administration of hepatitis B immunoglobulin and the HBV vaccine to the newborn infant directly after birth, perinatal infection with HBV can be prevented. This immunization procedure leads to a rapid and efficient anti-HBs response in the newborn comparable to that of adults. Protection against HBV infection by passive immunization is sufficient until active anti-HBs antibody formation is starting. The hepatitis B vaccine consists of the purified non-infectious surface of the HB virus. Due to the physical purification and chemical inactivation of the hepatitis B surface antigen (HBsAg) from human sera, the vaccine is considered to be safe. It is not harmful and exhibits an excellent compatibility in newborn infants.
mesh_terms: D002353:Carrier State / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006509:Hepatitis B / Q000276:immunology / Q000517:prevention & control*; D006514:Hepatitis B Surface Antigens / Q000276:immunology; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology; D014765:Viral Vaccines / Q000276:immunology / Q000627:therapeutic use*
chemical_list: D006514:Hepatitis B Surface Antigens; D014765:Viral Vaccines
vernacular_title: Die Immunprophylaxe der Hepatitis B beim Kind.