title: [The effect of alcohol on DMNA synthesis from its precursors in vivo and in vitro].
abstract: The study was concerned with a comparison of the effects of ethanol on N-nitrosodimethylamine (NDMA) synthesis from amidopyrine and sodium nitrite in rat stomach and on the same synthesis from dimethylamine (DMA) and sodium nitrite involving a 30-min incubation of their mixture at 37 degrees C in acid medium. Alcohol was found to inhibit DMA nitrosation thus lowering the yield of NDMA both in rat stomach and in a medium containing human gastric juice or glycine-hydrochloride buffer (pH = 3.4).
mesh_terms: D000818:Animals; D001711:Biotransformation; D055598:Chemical Phenomena; D002621:Chemistry; D003864:Depression, Chemical; D004123:Dimethylamines; D004128:Dimethylnitrosamine / Q000138:chemical synthesis / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D005750:Gastric Juice / Q000378:metabolism; D007408:Intestinal Absorption; D051379:Mice; D012977:Sodium Nitrite; D014018:Tissue Distribution
chemical_list: D004123:Dimethylamines; D000431:Ethanol; C034516:dimethylamine; D012977:Sodium Nitrite; D004128:Dimethylnitrosamine
vernacular_title: Vliianie alkogolia na sintez NDMA iz ego predshestvennikov v opytakh in vivo i in vitro.