Aldrin epoxidase and dimethylhydrazine demethylase activities in tumorous and non-tumorous tissue of the human colon and rectum.
High activities of aldrin epoxidase and dimethylhydrazine demethylase were found in human colon and rectum mucosa, the first being as high as in human liver biopsy specimens. Comparisons between tumorous (adenocarcinomas) and non-tumorous tissues of the same individuals revealed loss of activities in tumorous specimens. The presence of epoxidizing enzymes and demethylation of the organ-specific colon carcinogen dimethylhydrazine (DMH) in the intestinal muscosa of tumor-bearing patients implicate them with chemical carcinogenesis also in humans.
D000230:Adenocarcinoma / Q000201:enzymology*; D000452:Aldrin / Q000378:metabolism; D001711:Biotransformation; D003110:Colonic Neoplasms / Q000201:enzymology*; D004127:Dimethylhydrazines / Q000378:metabolism; D004851:Epoxide Hydrolases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000201:enzymology*; D008099:Liver / Q000201:enzymology; D008297:Male; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism*; D012004:Rectal Neoplasms / Q000201:enzymology*
D004127:Dimethylhydrazines; D010089:Oxidoreductases, N-Demethylating; D004851:Epoxide Hydrolases; D000452:Aldrin