Structural similarities among concanavalin A, haptoglobin, and trypsin.
Comparison of the primary structure of concanavalin A with those of trypsin and beta (heavy) chain of haptoglobin revealed a significant degree of chemical similarity. The amino acid sequence of concanavalin A was found to be 53.6% related to trypsin and haptoglobin. Certain analogy in the tertiary structure was shown by the use of thionine binding to the specific active site, characteristic for serine proteases.
D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D003208:Concanavalin A; D006242:Haptoglobins; D006801:Humans; D013045:Species Specificity; D013053:Spectrophotometry; D013329:Structure-Activity Relationship; D014357:Trypsin
D006242:Haptoglobins; D003208:Concanavalin A; D014357:Trypsin