Receptor-like activity of a monoclonal anti-idiotypic antibody against an anti-acetylcholine receptor antibody.
A monoclonal anti-idiotypic antibody against an anti-acetylcholine receptor antibody from a patient with myasthenia gravis was shown to bind the cholinergic ligand alpha-bungarotoxin. This binding could be inhibited by other cholinergic ligands, both antagonists and agonists. The anti-idiotype was also able to elicit the production of anti-receptor antibodies in mice. Thus, the anti-idiotype had functional properties similar to those of the original antigen, the acetylcholine receptor.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000008:administration & dosage / Q000502:physiology*; D000917:Antibody Formation; D001666:Binding Sites, Antibody / Q000187:drug effects; D001667:Binding, Competitive; D002038:Bungarotoxins / Q000378:metabolism; D002217:Carbachol / Q000378:metabolism; D005703:Gallamine Triethiodide / Q000378:metabolism; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011950:Receptors, Cholinergic / Q000276:immunology*; D014403:Tubocurarine / Q000378:metabolism
D000911:Antibodies, Monoclonal; D002038:Bungarotoxins; D007130:Immunoglobulin Idiotypes; D011950:Receptors, Cholinergic; D002217:Carbachol; D005703:Gallamine Triethiodide; D014403:Tubocurarine