Further investigation of the discriminative stimulus properties of MDA.
Rats trained to discriminate either (+)-amphetamine or (+/-)-MDA from saline in a two-lever drug discrimination task, were used to study the stimulus effects of MDA and its two optical isomers. Amphetamine-stimulus generalization occurred to S(+)-MDA, but not to its enantiomer R(-)-MDA. This, coupled with our earlier finding of DOM-stimulus generalization to R(-)-MDA but not to S(+)-MDA, suggests that the stimulus effects of S(+)-MDA are predominantly amphetamine-like while those of R(-)-MDA are more DOM-like. Thus, animals trained to discriminate racemic MDA from saline can apparently recognize members of both classes of agents.
D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine / Q000494:pharmacology; D015104:3,4-Methylenedioxyamphetamine / Q000494:pharmacology*; D000661:Amphetamine / Q000494:pharmacology; D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D003913:Dextroamphetamine / Q000494:pharmacology; D004193:Discrimination Learning / Q000187:drug effects*; D007536:Isomerism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000662:Amphetamines; D004290:DOM 2,5-Dimethoxy-4-Methylamphetamine; D015104:3,4-Methylenedioxyamphetamine; D000661:Amphetamine; D003913:Dextroamphetamine