Beyond the therapeutic window: a case presentation.
The relationship of haloperidol dose and plasma concentration to psychotic symptoms of schizophrenia is described. The authors present evidence supporting a therapeutic window hypothesis, in which an individual patient's course follows an inverted U curve. The clinical implications for dosage strategies are discussed.
D000328:Adult; D000553:Ambulatory Care; D004334:Drug Administration Schedule; D006220:Haloperidol / Q000008:administration & dosage* / Q000097:blood; D006760:Hospitalization; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D012565:Schizophrenic Psychology
D006220:Haloperidol