Reversible inhibition of spermatogenesis by danazol with combination of testosterone enanthate in rabbit.
Danazol (15 mg/kg b.w./day; oral) with combination of testosterone enanthate (5 mg/kg b.w./15 days; S.C.) was tested in male rabbits for reversible suppression of spermatogenesis. Semen analyses for efficacy and reversibility were performed biweekly. The regimen resulted in complete azoospermia or severe oligozoospermia in all the animals within 75 days of treatment accompanied with decreased motility, vitality and increased sperm abnormalities. Semen volume and pH did not alter significantly. Libido was unaffected. All seminal characteristics were within normal range after 115 days of recovery. In conclusion, the drug combination in given dose regimen resulted in reversible inhibition of spermatogenesis in rabbits.
D000818:Animals; D003272:Contraceptive Agents, Male / Q000494:pharmacology*; D003613:Danazol / Q000494:pharmacology*; D004338:Drug Combinations; D008297:Male; D011245:Pregnadienes / Q000494:pharmacology*; D011817:Rabbits; D012661:Semen / Q000032:analysis; D013091:Spermatogenesis / Q000187:drug effects*; D013739:Testosterone / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors
D003272:Contraceptive Agents, Male; D004338:Drug Combinations; D011245:Pregnadienes; D013739:Testosterone; C004648:testosterone enanthate; D003613:Danazol