Presence of a Tamm-Horsfall-like glycoprotein in the CSF of neurology patients. First results.
A protein antigenically similar to Tamm-Horsfall glycoprotein ( THLG ) was determined in CSF by affinity chromatography followed by a radioimmunological assay. THLG seems not to be a constituent of normal CSF or an autoantigen. It probably originates from nervous tissue and not from plasma proteins. Its mean is higher in the CSF of multiple sclerosis patients than in the CSF of degenerative disorders patients. THLG seems to be a chemical component of neuronal membrane and its physiological functions remain unknown.
D001812:Blood-Brain Barrier; D002493:Central Nervous System Diseases / Q000473:pathology; D003711:Demyelinating Diseases / Q000134:cerebrospinal fluid* / Q000276:immunology; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000473:pathology; D008297:Male; D009088:Mucoproteins / Q000097:blood / Q000134:cerebrospinal fluid*; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000276:immunology; D009336:Necrosis / Q000378:metabolism; D058949:Uromodulin
D009088:Mucoproteins; C548612:UMOD protein, human; D058949:Uromodulin