The inhibitory effect of D-glucosamine on thymidine kinase in chick embryo retinas and HeLa cells.
D-Glucosamine markedly inhibits thymidine incorporation into the TCA-insoluble fraction and thymidine kinase activity in HeLa cells. Both the inhibitory effects are also observed in isolated retinas of chick embryos. In this case the inhibitory effects are age-dependent and the magnitude of the responses decreases with embryonic development. In addition the time of exposure to D-glucosamine which is necessary to reveal the inhibitory effect on thymidine kinase increases with the age of the embryos.
D000367:Age Factors; D000818:Animals; D002642:Chick Embryo; D004247:DNA / Q000096:biosynthesis; D005260:Female; D005944:Glucosamine / Q000494:pharmacology*; D006367:HeLa Cells; D006801:Humans; D012160:Retina / Q000187:drug effects / Q000196:embryology*; D013936:Thymidine / Q000378:metabolism*; D013937:Thymidine Kinase / Q000037:antagonists & inhibitors*
D004247:DNA; D013937:Thymidine Kinase; D005944:Glucosamine; D013936:Thymidine