Age dependent changes on jejunal sugar absorption by rat in vivo.
Jejunal absorption of D-Glucose, D-Galactose and L-Arabinose was studied in 21-23 day, 2-3 month and 18 month-old rats for 5 minute periods using a perfusion technique. Sugar concentrations were: 2.5, 5, 10, 20 and 40 mM at each age. In some experiments phlorizin was used to determine the diffusional component of absorption. The saturation for D-Glucose was at 10 mM and 5 mM for D-Galactose. A reduction in the rate of total sugar absorption was observed with aging. Moreover, the active transport/simple diffusion ratio also decreases with age, specially at low substrate concentrations.
D000375:Aging; D000818:Animals; D001089:Arabinose / Q000378:metabolism; D050260:Carbohydrate Metabolism; D005260:Female; D005690:Galactose / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects; D007583:Jejunum / Q000378:metabolism*; D008297:Male; D010695:Phlorhizin / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D001089:Arabinose; D010695:Phlorhizin; D005947:Glucose; D005690:Galactose