title: [Functional state of the myocardium during stenocardia induced by isoproterenol].
abstract: Hemodynamic changes in healthy subjects versus patients with chronic coronary heart disease are compared. In cases of isoproterenol caused tachycardia, the patients developing angina showed a less prominent beneficial inotropic effect as compared with healthy subjects and angina-free patients. The initiation of drug infusion led to a marked increase in the rheographic index of myocardial contractility; however, already in the initial stages of ST segment depression, this parameter was characterized by a reversed time-course which progressed with the increasing electrocardiographic signs of myocardial ischemia. The degree of the observed impairments of the patients' inotropic response correlated with the severity of myocardial ischemia and the nature of the disease course.
mesh_terms: D000328:Adult; D000787:Angina Pectoris / Q000503:physiopathology*; D002302:Cardiac Output; D003327:Coronary Disease / Q000503:physiopathology*; D004562:Electrocardiography; D005080:Exercise Test; D006321:Heart / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D007545:Isoproterenol; D008297:Male; D008875:Middle Aged
chemical_list: D007545:Isoproterenol
vernacular_title: Funktsional'noe sostoianie miokarda vo vremia stenokardii, vyzvannoĭ izoproterenolom.