IgG subclasses in collagen-induced arthritis in the rat.
Using a solid-phase double-antibody radioimmunoassay IgG antibodies to native bovine type II collagen were measured as total IgG and as subclasses of IgG (IgG1, IgG2a, IgG2b, IgG2c ) in arthritic and non-arthritic Sprague-Dawley rats. Statistically significant differences were observed between arthritic and non-arthritic animals for IgG1, IgG2a, IgG2b and total IgG. The significance of these results and their possible relevance to the human disease are discussed.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D001168:Arthritis / Q000276:immunology*; D001169:Arthritis, Experimental / Q000276:immunology*; D003094:Collagen / Q000276:immunology*; D005260:Female; D007074:Immunoglobulin G / Q000145:classification / Q000276:immunology*; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains
D000906:Antibodies; D007074:Immunoglobulin G; D003094:Collagen