Serum potassium and aldosterone levels in gossypol-treated rats.
Male rats fed with 30 mg/kg gossypol for 2 or 4 weeks exhibited a decrease in growth but showed no change from control in serum potassium levels. Serum aldosterone levels remained unchanged, but serum testosterone levels were significantly reduced after 4 weeks of treatment. Serum T3 was significantly increased after 2 or 4 weeks of treatment, while serum T4 was not different from control. It is concluded that gossypol at a dose that is sufficient to produce sterility in rats did not change serum potassium and aldosterone levels.
D000450:Aldosterone / Q000097:blood*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D006072:Gossypol / Q000494:pharmacology*; D008297:Male; D011188:Potassium / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains; D013739:Testosterone / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
D014284:Triiodothyronine; D013739:Testosterone; D000450:Aldosterone; D006072:Gossypol; D013974:Thyroxine; D011188:Potassium