[Differentiation of stem cells from different parts of the hematopoietic system of adult thymectomized CBA mice stimulated with thymarin or cortexine].
Essential differences were detected in differentiation of GFUs from bone marrow and peripheral blood. It was shown that as a result of thymectomy of adult animals the ability of bone marrow CFUs to form granulocytic colonies decreased and that of splenic CFUs to form erythroid colonies increased. The immunostimulating low-molecular-weight polypeptides, thymarin and cortexine , normalized the differentiation of CFUs from bone marrow and spleen but interfered with the formation of erythroid colonies from CFUs of peripheral blood of thymectomized mice.
D000818:Animals; D001773:Blood Cells / Q000502:physiology; D001853:Bone Marrow / Q000502:physiology; D002454:Cell Differentiation; D002540:Cerebral Cortex; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010455:Peptides / Q000494:pharmacology*; D013154:Spleen / Q000502:physiology; D013934:Thymectomy; D013950:Thymus Gland / Q000502:physiology; D013951:Thymus Hormones / Q000494:pharmacology*
D010455:Peptides; D013951:Thymus Hormones; C017757:thymarin
Differentsirovka stvolovykh krovetvornykh kletok iz razlichnykh otdelov krovetvornoĭ sistemy vzroslykh timéktomirovannykh mysheĭ CBA, stimulirovannykh timarinom ili korteksinom.