Pepsinogen gastrin mesor ratio: a potential simple marker for gastric secretory function.
As compared to control subjects, patients with duodenal ulcer show decreased levels of serum G and increased levels of serum Group I pepsinogen (PGI). On the other hand, pregnant women in their third trimester show an increased level of serum G and decreased levels of serum PGI. Gastrin stimulates gastric secretion and has a trophic effect on the parietal cells. Concentrations of PGI in serum reflect the capacity of pepsin-secreting cells which are, in turn, closely related to the parietal cell mass. Pepsinogen/G ratio (PGI/G) could represent the effective acid-peptic secretory capacity. This study suggests that for screening and clinical purposes PGI/G ratio provides a good potentially discriminatory marker of gastric secreting capacity reliably correlating and improving the diagnostic significance of single G and/or PGI serum levels.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002940:Circadian Rhythm; D004381:Duodenal Ulcer / Q000378:metabolism; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010435:Pepsinogens / Q000097:blood*; D011247:Pregnancy
D005755:Gastrins; D010435:Pepsinogens