Intrarenal blood coagulation induced by ischemia in rats. Heparin and thrombocytopenia does not prevent the intracortical fibrin formation.
In various human and experimental renal failures some hemostatic parameters indicate the occurrence of intrarenal blood coagulation (1, 2). However, the fact that the common anticoagulants fail to cure the acute renal failure (3) appears to suggest either that they are ineffective against the intrarenal blood coagulation or no causal relationship exists between the hemostatic disturbances and impaired renal function. Therefore this study was undertaken to investigate the relationship between coagulation and impairment of renal function after a 45-min ischemic period in untreated, heparin-treated and in heparin- plus antiplatelet serum (APS)-treated thrombocytopenic animals.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001792:Blood Platelets / Q000276:immunology; D005337:Fibrin / Q000096:biosynthesis*; D006493:Heparin / Q000627:therapeutic use*; D007106:Immune Sera / Q000494:pharmacology; D007511:Ischemia / Q000097:blood*; D007672:Kidney Cortex / Q000378:metabolism; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012079:Renal Circulation; D013921:Thrombocytopenia / Q000097:blood*
D007106:Immune Sera; D005337:Fibrin; D006493:Heparin