[Morphological findings in lymph nodes, spleen and liver in the rat following treatment with polyvinylpyrrolidone and trypan blue (light microscopy studies)].
Lymph nodes, spleen and liver from 36 rats were studied by light microscope following prolonged administration of PVP and TB. When PVP had been administrated, the invasion of all the organs by large foam cells of RES was apparent while the structure of the organs had been destroyed. The animals which had received PVP combined with TB had less reticuloendotheliosis of the organs while their structure was maintained to a greater extent. The latter animals also had greater cellular reaction. All the rats showed obvious cachexia which was more apparent in those having received only PVP.
D000818:Animals; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008198:Lymph Nodes / Q000187:drug effects / Q000473:pathology; D008297:Male; D009369:Neoplasms / Q000139:chemically induced; D011205:Povidone / Q000009:adverse effects; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000187:drug effects* / Q000473:pathology; D014343:Trypan Blue / Q000009:adverse effects*
D011205:Povidone; D014343:Trypan Blue
Morphologische Befunde an Lymphknoten, Milz und Leber der Ratte nach Behandlung mit Polyvinylpyrrolidon und Trypanblau (lichtmikroskopische Untersuchungen).