Hydroxy- and amino-protection based on the 4-dimethylcarbamoylbenzyl group.
0-4-Dimethylcarbamoylbenzyl-L-tyrosine, N (epsilon)-4-dimethylcarbamoylbenzyloxycarbonyl-L-lysine, and simple derivatives, have been prepared. The protecting groups are markedly more stable to trifluoroacetic acid than are the unsubstituted benzylanalogues. N-t-Butoxycarbonyl-O-4-dimethylcarbamoylbenzyl-L-serine (cyclohexylammonium salt) is also described.
D001592:Benzyl Alcohols; D055598:Chemical Phenomena; D002621:Chemistry; D008239:Lysine / Q000031:analogs & derivatives; D010455:Peptides / Q000138:chemical synthesis*; D012995:Solubility; D014443:Tyrosine / Q000031:analogs & derivatives
D001592:Benzyl Alcohols; D010455:Peptides; D014443:Tyrosine; C024386:4-dimethylcarbamoylbenzyl alcohol; D008239:Lysine