Inhibition of DNA synthesis by retinyl acetate during chemically induced mammary carcinogenesis.
The effect of retinoids on DNA synthesis was studied in the female Sprague-Dawley rat. Animals were treated with either solvent, 7,12-dimethylbenz(a)anthracene, or 1-methyl-1-nitro-sourea at 50 days of age and were placed on either placebo or retinyl acetate diet at 57 days of age. [3H]Thymidine incorporation into purified DNA isolated from mammary parenchymal cells was determined. Retinyl acetate effectively inhibited mammary cell DNA synthesis in both 1-methyl-1-nitrosourea- and 7,12-dimethylbenz(a)anthracene-treated animals; however, DNA synthesis in solvent-treated animals was unaffected.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors; D000818:Animals; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D004224:Diterpenes; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D008770:Methylnitrosourea / Q000037:antagonists & inhibitors; D011230:Precancerous Conditions / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D000084562:Retinyl Esters; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000096:biosynthesis
D004273:DNA, Neoplasm; D004224:Diterpenes; D000084562:Retinyl Esters; D014801:Vitamin A; C009166:retinol acetate; D015127:9,10-Dimethyl-1,2-benzanthracene; D008770:Methylnitrosourea