Mutagenicity of diisopropylamine dichloroacetate, the "active constituent" of vitamin B15 (pangamic acid).
Diisopropylamine dichloroacetate, the active component of many formulations of pangamic acid (trade-named "vitamin B15"), and diisopropylamine, a component of diisopropylamine dichloroacetate, both demonstrate mutagenicity in the Ames Salmonella/mammalian microsome mutagenicity test. Ninety percent of such agents prove carcinogenic, and this long-term possibility must be considered in any proposed use of pangamic acid containing diisopropylamine or diisopropylamine dichloroacetate.
D002125:Calcium Gluconate; D004305:Dose-Response Relationship, Drug; D009152:Mutagenicity Tests; D009153:Mutagens; D034442:N-substituted Glycines; D011437:Propylamines / Q000008:administration & dosage / Q000009:adverse effects*; D000644:Quaternary Ammonium Compounds / Q000008:administration & dosage / Q000009:adverse effects*; D012486:Salmonella typhimurium / Q000187:drug effects; D014803:Vitamin B Complex / Q000009:adverse effects
D009153:Mutagens; D034442:N-substituted Glycines; D011437:Propylamines; D000644:Quaternary Ammonium Compounds; D014803:Vitamin B Complex; C001002:diisopropylamine dichloroacetate; C007442:diisopropylamine; C105565:pangamic acid; D002125:Calcium Gluconate