Effects of gamma-butyrolactone, amphetamine, and haloperidol in mice differing in sensitivity to alcohol.
Gamma-butyrolactone (GBL) induced longer loss of righting reflex in mice (LS-line) selectively bred for greater sensitivity to ethanol than in less sensitive SS-line mice. GBL also induced a three-fold greater increase of brain dopamine levels in LS than in SS mice. Among three inbred strains, GBL-induced loss of righting reflex was greater in BALB/c, and greater in DBA/2 than in C57BL/6 mice. A low dose of GBL produced biphasic effects on locomotor activity. Both an initial depressant action and a later increase in activity were greater in LS than in SS mice. These GBL effects on activity were modified in a genotype-dependent fashion by amphetamine. Results of these experiments as well as greater catalepsy-inducing properties of haloperidol in SS mice suggest that genotypic influences on motor reactivity to ethanol may be modeled by GBL effects on brain dopamine systems.
D015107:4-Butyrolactone / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D000431:Ethanol / Q000494:pharmacology*; D005663:Furans / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains; D009638:Norepinephrine / Q000378:metabolism; D012737:Sex Factors; D013045:Species Specificity
D005663:Furans; D000431:Ethanol; D006220:Haloperidol; D015107:4-Butyrolactone; D003913:Dextroamphetamine; D004298:Dopamine; D009638:Norepinephrine