[Relationship between the presence of plasmid pKM101 and the frequency of spontaneous and induced mutations of different kinds].
Ames tester strains of Salmonella typhimurium containing plasmid pKM101 have been shown to be very sensitive to UV-induced base substitutions and frameshift mutations. Plasmid pKM101 mediates the ability for base substitutions through frameshift inducing mutagens and slightly enhances frameshift mutagenesis. For the agents mainly inducing base-pair substitutions, plasmid pKM101 is found to enhance slightly the rate of base-pair substitutions but not the rate of frameshift mutations.
D015112:4-Nitroquinoline-1-oxide / Q000633:toxicity; D005020:Ethyl Methanesulfonate / Q000633:toxicity; D008769:Methylnitronitrosoguanidine / Q000633:toxicity; D009153:Mutagens / Q000633:toxicity; D009154:Mutation; D009930:Organic Chemicals; D010957:Plasmids; D012486:Salmonella typhimurium / Q000235:genetics* / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects
D009153:Mutagens; D009930:Organic Chemicals; D008769:Methylnitronitrosoguanidine; D015112:4-Nitroquinoline-1-oxide; C025749:preparation No. 012074; D005020:Ethyl Methanesulfonate
Zavisimost' chastoty spontannykh i indutsirovannykh mutatsiĭ razlichnoĭ prirody ot nalichiia plazmidy pKM101.