Inhibition of polycyclic aromatic hydrocarbon-induced neoplasia by sodium cyanate.
The effects of sodium cyanate on the occurrence of 7,12-dimethylbenz(a)anthracene- and benzo(a)pyrene-induced neoplasia have been studied in rodents. Sodium cyanate added to the diet for 8 days prior to challenge with 7,12-dimethylbenz(a)anthracene inhibits 7,12-dimethylbenz(a)anthracene-induced mammary neoplasia in female Sprague-Dawley rats. Likewise, sodium cyanate in the diet inhibits the occurrence of benzo(a)pyrene-induced neoplasia of the forestomach and lung of ICR/Ha mice. Inhibition of benzo(a)pyrene-induced pulmonary neoplasia in A/J mice also is brought about by this compound. The identification of sodium cyanate as an inhibitor of chemical carcinogenesis adds a new chemical structure to those found previously to have inhibitory properties.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000037:antagonists & inhibitors*; D001580:Benzopyrenes / Q000037:antagonists & inhibitors*; D003485:Cyanates / Q000494:pharmacology*; D005260:Female; D008175:Lung Neoplasms / Q000517:prevention & control; D008325:Mammary Neoplasms, Experimental / Q000517:prevention & control; D051379:Mice; D008813:Mice, Inbred ICR; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D013274:Stomach Neoplasms / Q000517:prevention & control
D001551:Benz(a)Anthracenes; D001580:Benzopyrenes; D003485:Cyanates; D015127:9,10-Dimethyl-1,2-benzanthracene