Selective uptake of alloxan by pancreatic B-cells.
Alloxan rapidly binds to or accumulates in pancreatic B-cells as distinct from non-B-cells. The selective uptake of this cytotoxic agent by the insulin-producing B-cells might account for its well-known diabetogenic effect.
D000496:Alloxan / Q000378:metabolism*; D000818:Animals; D002469:Cell Separation; D066298:In Vitro Techniques; D007515:Islets of Langerhans / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D000496:Alloxan