Altered cerebral inhibition of respiratory and cardiac responses to hypercapnia in acute stroke.
Ventilatory and heart-rate responses to hypercapnia were evaluated by a CO2 rebreathing technique in 56 patients with acute ischemic stroke and 14 normal controls. Both ventilatory and heart-rate responses were increased in patients with hemispheral lesions, but not in patients with brainstem lesions. In patients with hemispheral infarct, there was a decrease in CO2 sensitivity 1 to 3 weeks later. Acute hemisphere lesions may result in a transient decrease of cerebral inhibition of brainstem-mediated autonomic responses to a chemical stimulus.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002245:Carbon Dioxide / Q000097:blood / Q000502:physiology; D002544:Cerebral Infarction / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D006339:Heart Rate; D006801:Humans; D006935:Hypercapnia / Q000097:blood / Q000150:complications / Q000503:physiopathology*; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D012119:Respiration; D013990:Tidal Volume
D002245:Carbon Dioxide; D010100:Oxygen