Effect of intraperitoneally administered GABA on haloperidol-induced catalepsy in the rat.
Pretreatment with GABA (250--1,000 mg/kg IP) potentiated the cataleptogenic effect of haloperidol in a dose-dependent manner in rats. GABA (GABA, B.D.H. Ltd.) alone in a dose of 2,000 mg/kg (IP) also induced catalepsy. The results may be due to partial access of blood-borne GABA to the CNS, leading to inhibition of nigro-striatal dopaminergic neurons involved in the functioning of the corpus striatum.
D000818:Animals; D002375:Catalepsy / Q000139:chemically induced*; D004347:Drug Interactions; D006220:Haloperidol / Q000494:pharmacology*; D006801:Humans; D007274:Injections, Intraperitoneal; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000008:administration & dosage / Q000494:pharmacology*
D005680:gamma-Aminobutyric Acid; D006220:Haloperidol