Vanadate: non-selective inhibition of transepithelial transport of Na+, H+ and water.
In the isolated urinary bladder of the toad, 10(-5)-10(-4)M orthovanadate produces inhibition of the active transport of Na+ and H+ ions as well as of antidiuretic hormone-mediated osmotic flow of water. Since transport of H+ ions and osmotic water flow are not inhibited when (Na+ + K+)-ATPase is inhibited by ouabain, biological actions of vanadate are not necessarily related to inhibition of (Na+ + K+)-ATPase.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001834:Body Water / Q000378:metabolism*; D002024:Bufo marinus; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D012964:Sodium / Q000378:metabolism*; D001743:Urinary Bladder / Q000378:metabolism*
D012964:Sodium