Treatment of infected urinary stones in rats by a new hydroxamic acid, "N-(pivaloyl)glycinohydroxamic acid.
The effectiveness of a new urease inhibitor, N-(pivaloyl)glycinohydroxamic acid, in the treatment of infected urinary stones was investigated. The hydroxamic acid markedly inhibited and alkalinisation of urine and stone formation when it was administered orally to rats with urinary tract infection caused by Proteus mirabilis; its inhibitory effect was potentiated by concomitant treatment with Cephalexin. This compound may become a useful medicine for the treatment of struvite stones.
D000818:Animals; D006877:Hydroxamic Acids / Q000627:therapeutic use*; D008297:Male; D011512:Proteus Infections / Q000150:complications; D011513:Proteus mirabilis; D051381:Rats; D011919:Rats, Inbred Strains; D014545:Urinary Calculi / Q000188:drug therapy* / Q000209:etiology; D014552:Urinary Tract Infections / Q000150:complications
D006877:Hydroxamic Acids; C032346:N-(pivaloyl)glycinohydroxamic acid