Postcoital contraception with an injectable estrogen preparation (Org 369 - 2).
In one-hundred women age 15 to 45, postcoital contraception was attempted with a "morning-after" injection consisting of 12.5 mg estradiol-benzoate and 10 mg of estradiol-phenylpropionate. Plasma estradiol-178, progesterone, LH, FSH and Prl were measured by specific radioimmunoassays and BBT was recorded. In 97.8% the injection was given within 48 hours after unprotected coitus. The medication induced minimal cycle and bleeding pattern changes. The rate of side effects was low. The incidence of pregnancies due to medication failure was 3%. The plasma hormone patterns before and under therapy are demonstrated and drug-induced changes discussed.
D000293:Adolescent; D000328:Adult; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage / Q000009:adverse effects; D003281:Contraceptives, Postcoital / Q000009:adverse effects; D003692:Delayed-Action Preparations; D004958:Estradiol / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008875:Middle Aged; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood
D003277:Contraceptives, Oral, Combined; D003281:Contraceptives, Postcoital; D003692:Delayed-Action Preparations; D011374:Progesterone; D004958:Estradiol; C028177:Org 369-2; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone