[Changes in rat polynuclear leukocyte chemotaxis during experimental].
Specific receptor sites for the chemotactic peptide F-Met-Leu-Phe had been demonstrated on polymorphonuclear leucocytes isolated from Rats presenting, or not, an acute inflammatory reaction. A significant decrease of the chemotactic responsiveness of inflammatory cells had been measured by two different methods of assessment performed in parallel. This phenomenon is not related to a loss of peptide binding sites but an increase of adhesiveness would be implied in this mechanism.
D000818:Animals; D002448:Cell Adhesion; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D007249:Inflammation / Q000097:blood* / Q000139:chemically induced; D009504:Neutrophils; D010455:Peptides / Q000494:pharmacology; D051381:Rats; D011955:Receptors, Drug / Q000032:analysis
D010455:Peptides; D011955:Receptors, Drug
Modification de chimiotactisme des polynucléaires de rat au cours de l'inflammation expérimentale.