Thrombolytic therapy for venous thrombosis in patients with gastro-intestinal diseases.
Venous thrombosis in 2 patients with gastro-intestinal diseases (chronic liver disease and ulcerative colitis) is reported. A good clinical improvement was obtained after thrombolytic (urokinase) therapy without any haemorrhagic side-effect. A decrease in the plasma of the fast-acting antiplasmin has been correlated with urokinase thrombolytic effect in vivo. These preliminary reports suggest that thrombolytic drugs are a safe tool for the treatment also of thromboembolic complications in patients with potential haemorrhagic diathesis.
D000368:Aged; D010450:Endopeptidases / Q000627:therapeutic use*; D005260:Female; D005767:Gastrointestinal Diseases / Q000150:complications*; D006801:Humans; D008108:Liver Diseases, Alcoholic / Q000150:complications; D008297:Male; D008875:Middle Aged; D013924:Thrombophlebitis / Q000188:drug therapy* / Q000209:etiology; D013997:Time Factors; D014568:Urokinase-Type Plasminogen Activator / Q000097:blood / Q000627:therapeutic use*
D010450:Endopeptidases; D014568:Urokinase-Type Plasminogen Activator