Chemotherapy of autochthonous leukemias induced by 7,12-dimethylbenz(a)anthracene in Long Evans rats.
A total of 111 autochthonous (primary) acute rat leukemias of the diffuse-hepatic type which had been induced by 7.12-dimethylbenz(a)anthracene were treated with mono- and combination chemotherapy. The survival time of treated rats increased significantly compared to untreated controls. A combination of vincristine (VCR), adriamycin (ADR), and cytosine arabinoside (Ara-C) was superior to a combination of VCR and ADR as well as to a monotherapy with Cyclophosphamide, BCNU, VCR, ADR, and Ara-C.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001551:Benz(a)Anthracenes; D004359:Drug Therapy, Combination; D005260:Female; D007942:Leukemia, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D051381:Rats
D000970:Antineoplastic Agents; D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene