Effect of neonatal injection of anti-mu antibodies on immunity to schistosomes (S. mansoni) in the rat.
The effect of neonatally initiated injections of anti-mu serum on immunity to reinfection with Schistosoma mansoni in the rat was investigated in vitro and in vivo. Anti-mu treatment resulting in a profound depression of immunoglobulin synthesis dramatically decreased immunity to reinfection assessed by worm recovery technique. Complement-dependent antibody, IgG2a antibody-eosinophil-mediated and IgE-macrophage cytotoxicity reactions were in parallel markedly reduced. These results show the prominent role played by antibody-dependent mechanisms in immunity to schistosomes in the rat.
D000818:Animals; D000831:Animals, Newborn; D000906:Antibodies / Q000008:administration & dosage*; D003602:Cytotoxicity, Immunologic; D005260:Female; D007106:Immune Sera / Q000494:pharmacology; D007072:Immunoglobulin D; D007073:Immunoglobulin E; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D007148:Immunoglobulin mu-Chains; D007274:Injections, Intraperitoneal; D008297:Male; D011817:Rabbits; D051381:Rats; D011919:Rats, Inbred Strains; D012550:Schistosoma mansoni / Q000276:immunology; D012552:Schistosomiasis / Q000517:prevention & control*
D000906:Antibodies; D007106:Immune Sera; D007072:Immunoglobulin D; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D007148:Immunoglobulin mu-Chains; D007073:Immunoglobulin E