Effect of alpha-difluoromethyl ornithine on the transplantable rat hepatoma 5123, 1-1.
Oral treatment with alpha-difluoromethyl ornithine (2.75 g/kg rat/day) simultaneous with subscapular implantation in Buffalo rats of the 5213, 1-1 hepatoma, retarded significantly the tumor growth rate for 20 days. The regimen also decreased tumor ornithine decarboxylase activity (ODC); however, the tumors growing despite treatment, maintained their malignant characteristics and ODC activity when re-transplanted into normal animals.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001835:Body Weight / Q000187:drug effects; D000518:Eflornithine; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000201:enzymology; D009368:Neoplasm Transplantation; D009952:Ornithine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D065108:Ornithine Decarboxylase Inhibitors; D051381:Rats; D014184:Transplantation, Homologous
D000970:Antineoplastic Agents; D065108:Ornithine Decarboxylase Inhibitors; D009952:Ornithine; D000518:Eflornithine