The influence of blood transfusion on cellular immunity.
To evaluate the effect of transfusion on immunity, we studied some immunological parameters in 14 uremic patients treated with 3 blood transfusions (5 with HLA-compatible and 9 with random transfusions). Before transfusions 8/14 patients were DNCB-negative; both spontaneous and active E-rosettes were below normal range. The parameters of humoral immunity (S-Ig, C3, C4, IC, CRP) were normal. After both the first and second transfusions an increase in T- and B-lymphocytes was found. The third transfusion led to a more pronounced and prolonged immunosuppression in patients treated with compatible transfusions than in those treated with random transfusions. Our findings suggest that blood transfusion--HLA-compatible transfusion in particular--results in an impairment of the lymphocyte role.
D000328:Adult; D000917:Antibody Formation; D001402:B-Lymphocytes / Q000276:immunology; D001803:Blood Transfusion; D005260:Female; D005455:Fluorescent Antibody Technique; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis; D007111:Immunity, Cellular; D008297:Male; D008875:Middle Aged; D012397:Rosette Formation; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology; D014511:Uremia / Q000276:immunology / Q000628:therapy*
D006680:HLA Antigens