Nodular lymphoma eventuating into lymphoplasmocytic lymphoma with monoclonal IgM/lambda cold agglutinin and Bence-Jones proteinuria.
A case of nodular lymphocytic (centroblastic/centrocytic) lymphoma that developed within 5 months after the initial diagnosis of lymphoplasmocytic lymphoma is described. The change in the histopathological picture, consisting of the development of a functionally more differentiated B cell neoplasm, occurred in the abdominal lymph nodes while the original pattern persisted in the bone marrow, liver and spleen. The patient was also found to have a serum IgM/lambda monoclonal immunoglobulin exhibiting cold agglutinin activity with specificity for the 'non-I' erythrocyte antigens.
D000373:Agglutinins; D001323:Autoantibodies; D001536:Bence Jones Protein / Q000652:urine; D002999:Clone Cells / Q000276:immunology; D003080:Cold Temperature; D006801:Humans; D007075:Immunoglobulin M; D008198:Lymph Nodes / Q000473:pathology; D008224:Lymphoma, Follicular / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D010954:Plasmacytoma / Q000175:diagnosis*
D000373:Agglutinins; D001323:Autoantibodies; D007075:Immunoglobulin M; D001536:Bence Jones Protein