Recognition of autologous and allogeneic lymphocytes and tumor cells by human natural killer cells.
The shedding of the mobile Fc receptor (FcR1) and the depletion of the immobile Fc receptor (FcR11) bearing human lymphocytes revealed that human natural killer cells belong to the FcR11-bearing population. Anti-beta-2-microglobulin treatment of the effector cells decreased natural cytotoxicity against some target cells and the detectability of HLA antigens, indicating that histocompatibility antigens or related structures may be involved in natural cytotoxicity. Using a panel of 29 autologous and allogenic PHA-stimulated target cells and peripheral lymphocytes from the same donors as the effector cells, distinct cytotoxic responses against allogeneic and autologous target cells were observed. A computer analysis of selective natural cytotoxicity distinguished seven different groups of target cells that may represent common structures for NK recognition.
D002460:Cell Line; D003602:Cytotoxicity, Immunologic; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D009369:Neoplasms / Q000276:immunology*; D011961:Receptors, Fc / Q000276:immunology; D012397:Rosette Formation; D001613:beta 2-Microglobulin / Q000276:immunology
D006680:HLA Antigens; D011961:Receptors, Fc; D001613:beta 2-Microglobulin