Defining tranquilizers operationally by non additive effect in experimental stress situations.
Clinically and theoretically, a tranquilizer should be more effective under stress than under non stress conditions. By transformation into a statistical non additivity equivalent, a 2 X 3 factorial design was derived with a drug factor (Cloxazolam as a tranquilizer) and a social stress factor. The results in healthy young subjects show a significant drug- x -stress interaction, indicating the non additivity of both treatments. Psychological interpretations, according to Yerkes-Dodson law, and therapeutic and experimental conclusions are added.
D000328:Adult; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008568:Memory / Q000187:drug effects; D010919:Placebos; D013315:Stress, Psychological / Q000523:psychology*; D014149:Tranquilizing Agents / Q000494:pharmacology*
D010919:Placebos; D014149:Tranquilizing Agents