Long-term management of rheumatoid arthritis with disalcid.
Disalcid, a salicylic acid pro-drug, was administered for 3 months to eighteen rheumatoid arthritis patients, with monitoring of clinical response, side-effects and laboratory changes. The drug produced a satisfactory to excellent response in fourteen patients and was unsatisfactory in four. Gastric side-effects occurred in three patients and allergic reaction in one. Serum salicylic acid concentrations were adequately maintained between 15 to 25 mg/100 ml. Funduscopic monitoring revealed one retinal defect in a patient with hypertension. Laboratory examinations, blood chemistry and urine analyses remained within normal limits during the 12-week trial.
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000097:blood / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D012459:Salicylates / Q000009:adverse effects / Q000627:therapeutic use*
D012459:Salicylates; C014182:salicylsalicylic acid