In vitro metabolism of putrescine by diamine oxidase in tissues of the pregnant rat.
The metabolism of 14C-putrescine by diamine oxidase was tested on the 19th day of pregnancy in different organs of rats. The highest turnover was found in maternal placenta and uterus where 94% of the reaction product was identified as delta 1-pyrroline. Considerable deamination rates were also observed in ovary, liver and fetal placenta where, however, gamma-aminobutyric acid was the predominant product. In the kidney only a small diamine oxidase activity was measured. No formation of spermidine or spermine from 14C-putrescine was detected.
D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism*; D000818:Animals; D005260:Female; D066298:In Vitro Techniques; D011247:Pregnancy; D011270:Pregnancy, Animal; D011700:Putrescine / Q000378:metabolism*; D011758:Pyrroles / Q000378:metabolism; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D011758:Pyrroles; C025565:delta(1)-pyrroline; D005680:gamma-Aminobutyric Acid; D006631:Amine Oxidase (Copper-Containing); D011700:Putrescine