[Cytogenetic study of preleukemic phases and of acute leukemia secondary to chemo-and/or radiotherapy. Review of the literature (102 cases)].
A review of the literature upon 102 cases with cytogenetic study of preleukemic states (Prel.) and/or acute secondary leukemia (ASL) following chemotherapy and/or radiotherapy treatment has been made. The karyotype was almost always abnormal (91%) of cases). There was a predominance of hypodiploidy with abnormalities including chromosome number 5 (-5 ou 5q-) and/or number 7 (7- or 7q-) (chromosomes studied with banding). The abnormalities were present in preleukemia state. The pattern of the acute secondary leukemia was particularly different from that acute leukemia de novo: high frequency of preleukemia state, ANLL type of leukemia, very bad prognosis, importance of cytogenetic abnormalities. There was a great interest in the study of the karyotype for the previous detection in ASL: this allowed their discovery as soon as the preleukemia state.
D000208:Acute Disease; D002869:Chromosome Aberrations; D002875:Chromosomes; D006801:Humans; D007049:Iatrogenic Disease; D007621:Karyotyping; D007938:Leukemia / Q000139:chemically induced / Q000235:genetics*; D007953:Leukemia, Radiation-Induced / Q000235:genetics*; D011289:Preleukemia / Q000235:genetics*; D011379:Prognosis
Etude cytogénétique des états préleucémiques et des leucémies aiguës secondaires à un traitement par chimiothérapie et/ou radiothérapie. Revue de la littérature de 102 observations.