Removal of specific antibody in vivo by whole blood immunoadsorption: preliminary results in dogs.
Effective immunoadsorption for removal of anti-red cell antibodies from plasma using affinity columns has been demonstrated. However, the requirement of a continuous-flow centrifuge to separate plasma increases the cost and complexity of the procedure. We have adapted red cell antigen immunoadsorption columns for use with whole blood. Effective and specific removal of anti-red cell antibodies was achieved in actively immunized dogs.
D000017:ABO Blood-Group System / Q000276:immunology*; D000818:Animals; D001781:Blood Component Removal; D003165:Complement System Proteins / Q000032:analysis; D004285:Dogs; D007114:Immunization; D007163:Immunosorbent Techniques; D007518:Isoantibodies / Q000032:analysis*; D007958:Leukocyte Count; D013997:Time Factors
D000017:ABO Blood-Group System; D007518:Isoantibodies; D003165:Complement System Proteins