Correlation of isotopic cisternographic patterns in multiple sclerosis with CSF IgG values.
Thirty-eight patients with multiple sclerosis (MS) were examined with isotopic cisternography (IC) in order to study cerebrospinal fluid (CSF) dynamics. Cisternography was also performed in 15 patients with amyotrophic lateral sclerosis and in 14 with senile dementia of the Alzheimer type as controls. IC pattern of "mixed" type was found in 18 MS patients and all those with Alzheimer senile dementia examined, while the IC examination did not show abnormality in any of 15 patients with amyotrophic lateral sclerosis. In MS patients, the abnormal IC picture proved to be significantly correlated with the CSF IgG values as calculated by Link's and Tourtelotte's formulas. The abnormal IC in MS may be due to altered CSF reabsorption or increased transependymal flow, or it may be related to the abnormal concentration of IgG.
D000328:Adult; D000544:Alzheimer Disease / Q000000981:diagnostic imaging; D000690:Amyotrophic Lateral Sclerosis / Q000000981:diagnostic imaging; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid*; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000000981:diagnostic imaging*; D009192:Myelography / Q000379:methods*; D004369:Pentetic Acid; D011877:Radionuclide Imaging; D013667:Technetium; D016284:Technetium Tc 99m Pentetate; D014057:Tomography, X-Ray Computed
D007074:Immunoglobulin G; D013667:Technetium; D004369:Pentetic Acid; D016284:Technetium Tc 99m Pentetate