Action of salbutamol on carbohydrate metabolism in the rat fetus.
The metabolic action of salbutamol in fetuses was studied after acute (day 21 of pregnancy) and chronic (5 daily infusions from day 16 to day 20 of pregnancy) treatment of pregnant rats. A single injection of salbutamol on day 21 of gestation induced an increase in plasma insulin levels prior to the rise of blood glucose concentration. After the chronic treatment, fetuses from treated mothers showed a decrease in insulin-secreting ability in response to a maternal glucose injection. However, no modifications in fetal liver and placental glycogen contents or in birth weight could be demonstrated. These results suggest that a chronic treatment of pregnant rats with salbutamol could affect the fetal pancreatic responsiveness to glucose.
D000420:Albuterol / Q000494:pharmacology*; D000818:Animals; D001786:Blood Glucose / Q000032:analysis*; D050260:Carbohydrate Metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006003:Glycogen / Q000032:analysis; D007328:Insulin / Q000097:blood; D008099:Liver / Q000032:analysis; D010920:Placenta / Q000032:analysis; D011247:Pregnancy; D051381:Rats / Q000196:embryology*; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D006003:Glycogen; D000420:Albuterol