Immunohistochemical demonstration of serotonin nerve fibers in the olfactory bulb of the rat, cat and monkey.
The distribution of serotonin (5-HT) positive fibers in the olfactory bulb of the rat, cat and monkey was studied using the peroxidase-anti-peroxidase (PAP) immunohistochemical method and highly specific antibodies to 5-HT. In general, 5-HT fibers were present throughout all layers in the olfactory bulb of these species except for the olfactory nerve layer and different as well as restricted laminar patterns of 5-HT distribution were observed. There were also species-related differences in the pattern of 5-HT distribution, in each layer. The most notable species difference was apparent in the glomerular layer of the main olfactory bulb. In case of the rat and cat, a very dense plexus of 5-HT fibers was observed to be diffuse in the glomerulus, while in the monkey, the distribution of 5-HT fibers was scanty and partial, as was seen in the accessory olfactory bulb of the rat.
D000818:Animals; D002415:Cats / Q000033:anatomy & histology; D007124:Immunoenzyme Techniques; D008251:Macaca / Q000033:anatomy & histology; D008297:Male; D009412:Nerve Fibers / Q000032:analysis*; D009830:Olfactory Bulb / Q000648:ultrastructure*; D051381:Rats; D011919:Rats, Inbred Strains / Q000033:anatomy & histology; D012701:Serotonin / Q000032:analysis*; D013045:Species Specificity
D012701:Serotonin