Cerebral oedema and blood-brain and blood-CSF barriers in experimental brain trauma: effect of indomethacin-A prostaglandin synthetase inhibitor.
Cerebral oedema often occurs following trauma to the brain. Recently several biogenic amines have been suggested for their possible mediation in the pathophysiology of traumatic brain oedema. The present investigation indirectly indicates that prostaglandins of E series are also involved in the etiology of cerebral oedema, since administration of a potent PG synthetase inhibitor, indomethacin significantly diminished oedematous swelling of traumatised rat brain.
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D001929:Brain Edema / Q000188:drug therapy* / Q000209:etiology; D001930:Brain Injuries / Q000150:complications* / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000187:drug effects; D002540:Cerebral Cortex / Q000293:injuries; D002555:Cerebrospinal Fluid / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors; D005260:Female; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D009929:Organ Size; D011453:Prostaglandins / Q000378:metabolism; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats
D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins; D011458:Prostaglandins E; D007213:Indomethacin