Bence Jones myeloma with a tetramer of kappa-type globulin in serum.
We describe a case of Bence Jones multiple myeloma involving two kappa-type monoclonal proteins. One was isolated from serum, the other from both serum and urine. After biochemical and immunochemical analyses, we concluded that one of the proteins was a tetramer, present in serum but not in urine, whereas the other was a monomer, which was excreted in large amounts in the urine during the terminal stage of the disease.
D001536:Bence Jones Protein / Q000652:urine*; D002850:Chromatography, Gel; D004588:Electrophoresis, Cellulose Acetate; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D046911:Macromolecular Substances; D008875:Middle Aged; D009101:Multiple Myeloma / Q000032:analysis* / Q000150:complications; D011507:Proteinuria / Q000209:etiology
D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D046911:Macromolecular Substances; D001536:Bence Jones Protein