Balanced bone marrow globin synthesis in mideastern alpha-thalassemia.
Hematological data and globin synthesis studies in 8 alpha-thalassemic children whose parents are from various regions in the Middle East are reported. All patients were devoid of Hb H. 5 of them had mild anemia, hypochromia and microcytosis and their blood alpha-/non-alpha-globin radioactivity ratios ranged between 0.56 and 0.75. The other 3 patients were hematologically normal with blood radioactivity ratios between 0.77 and 0.88. Bone marrow studies showed balanced globin chain synthesis for 6 of the patients and relatively more alpha-globin synthesis than in the blood for the remaining 2. The decrease in the relative synthesis of alpha-globin on erythroid cell maturation may relate to the molecular basis of alpha-thalassemia in the Middle East.
D001853:Bone Marrow / Q000378:metabolism*; D002648:Child; D002675:Child, Preschool; D046508:Culture Techniques; D004534:Egypt / Q000208:ethnology; D005914:Globins / Q000096:biosynthesis*; D006447:Hemoglobin H / Q000032:analysis; D006801:Humans; D007492:Iran / Q000208:ethnology; D007493:Iraq / Q000208:ethnology; D007557:Israel; D007585:Jews; D013789:Thalassemia / Q000097:blood / Q000378:metabolism*; D015006:Yemen / Q000208:ethnology
D005914:Globins; D006447:Hemoglobin H