Controlled therapeutic trials in motor neuron disease: methodologic considerations.
Many of the difficulties inherent in the design and implementation of controlled therapeutic trials have been discussed. Future studies must carefully address these issues. Perhaps the most practical advice on how these investigations should be carried out was offered by Cornfield, when he warned: "Be careful." (13)
D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006801:Humans; D009046:Motor Neurons / Q000187:drug effects; D009468:Neuromuscular Diseases / Q000188:drug therapy*; D010043:Outcome and Process Assessment, Health Care; D011897:Random Allocation