[Recent data on the metabolism of drugs by UDP-glucuronosyltransferases and sulfotransferases (author's transl)].
The authors review recent work on UDP-glucuronosyltransferases and sulfotransferases. UDP-glucuronosyltransferases are membrane enzymes which are strongly dependent on the lipid environment ; this is why they have only recently been isolated and purified. It seems at present, that at least two enzyme forms exist. The sulfotransferases are cytosol enzymes, more easily isolated. Their importance in the metabolism of drugs appears owing to an equilibrium with UDP-glucuronosyltransferases.
D000818:Animals; D005260:Female; D014453:Glucuronosyltransferase / Q000302:isolation & purification / Q000378:metabolism*; D007425:Intracellular Membranes / Q000201:enzymology; D007527:Isoenzymes / Q000378:metabolism; D008297:Male; D008563:Membrane Lipids / Q000502:physiology; D009747:Nutritional Physiological Phenomena; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010740:Phospholipases; D013466:Sulfurtransferases / Q000302:isolation & purification / Q000378:metabolism*
D007527:Isoenzymes; D008563:Membrane Lipids; D004364:Pharmaceutical Preparations; D014453:Glucuronosyltransferase; D013466:Sulfurtransferases; D010740:Phospholipases
Données récentes sur le métabolisme des médicaments par les UDP-glucuronosyltransférases et les sulfotransférases.