Nephrotoxicity of mild analgesics in the Gunn strain of rat.
1 Homozygous members of the Gunn strain of rat, mutant Wistars jaundiced from lack of the enzyme uridine diphosphate glucuronyl transferase, are highly susceptible to analgesic-induced renal papillary necrosis. 2 A single oral dose of aspirin, phenacetin or paracetamol will produce the lesion, a circumstance which does not occur in other strains. 3 The reasons for this susceptibility have not been determined, but the experimental model should prove useful in further studies of the nephrotoxicity of analgesic drugs.
D000082:Acetaminophen / Q000633:toxicity; D000700:Analgesics / Q000633:toxicity*; D000818:Animals; D001241:Aspirin / Q000633:toxicity; D014453:Glucuronosyltransferase / Q000172:deficiency; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D007679:Kidney Medulla / Q000473:pathology; D009154:Mutation; D010615:Phenacetin / Q000633:toxicity; D051381:Rats
D000700:Analgesics; D000082:Acetaminophen; D014453:Glucuronosyltransferase; D010615:Phenacetin; D001241:Aspirin