[Molecular mechanisms of homeostasis in human and animal tissues with disturbance of acid-base balance].
The paper deals with generalization of data from literature and results of own studies concerned with peculiarities in the course of main metabolic processes in people and animals under conditions of acidoses and alcaloses of an organism as compared to the normal level. Certain detected peculiarities of the metabolism the author considers as molecular homeostatic mechanisms of a cell which prevent to a considerable extent a sharp shift in pH of biological fluids. Attention is concentrated on the important independent regulatory significance of the HCO3- and CO2 concentrations in the cell for metabolism (independently of the pH value of tissue fluids). Possible applied importance of the detected metabolic peculiarities with the disturbance of acid-base balance in the human and animal organism is under discussion.
D000136:Acid-Base Equilibrium; D000137:Acid-Base Imbalance / Q000503:physiopathology*; D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D002245:Carbon Dioxide / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D006863:Hydrogen-Ion Concentration
D001639:Bicarbonates; D002245:Carbon Dioxide
Molekyuliarnye mekhanizmy gomeostaza v tkaniakh cheloveka i zhivotnykh pri narushenii kislotho-shchelochnogo ravnovesiia.