Production and biological activity of marcellomycin, an antitumor anthracycline antibiotic, and taxonomy of the producing organism.
An actinomycete, isolated from a soil sample from Ontario, Canada, was studied taxonomically and named Actinosporangium bohemicum sp. nov. strain C-36,145. This strain was found to produce a complex mixture of e-pyrromycinone glycosides having antitumor properties. Marcellomycin, a member of this complex, was selected for further study. Conditions for production of this antibiotic were developed in flask studies and scaled-up to the 3,000-liter fermentor stage.
D000192:Actinomycetales / Q000145:classification / Q000378:metabolism*; D000818:Animals; D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000627:therapeutic use; D002473:Cell Wall / Q000378:metabolism; D003470:Culture Media; D004926:Escherichia coli / Q000187:drug effects; D005285:Fermentation; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D009279:Naphthacenes / Q000096:biosynthesis / Q000627:therapeutic use
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D003470:Culture Media; D009279:Naphthacenes; C015338:marcellomycin