Use of single-agent antimicrobial therapy in the treatment of polymicrobial female pelvic infections.
One hundred twenty patients with either postpartum endomyometritis or postgynecologic surgical infections were treated either with ticarcillin, clindamycin, or chloramphenicol. One hundred nine (91%) responded successfully to single-agent antimicrobial therapy. Most of the infections were polymicrobial, involving both aerobic and anaerobic bacteria. Forty patients were treated with ticarcillin, with 90% responding successfully; 48 were treated with chloramphenicol, with 94% responding successfully; and 32 were treated with clindamycin, with 88% responding successfully. Single-agent antimicrobial therapy appears to be appropriate for treating polymicrobial obstetric and gynecologic soft tissue infections.
D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001419:Bacteria / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy*; D002585:Cesarean Section; D002701:Chloramphenicol / Q000627:therapeutic use; D002981:Clindamycin / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004716:Endometritis / Q000188:drug therapy; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy*; D006801:Humans; D010388:Pelvis / Q000382:microbiology; D011183:Postoperative Complications / Q000188:drug therapy; D011247:Pregnancy; D011644:Puerperal Disorders / Q000188:drug therapy; D011897:Random Allocation; D013982:Ticarcillin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D002981:Clindamycin; D002701:Chloramphenicol; D013982:Ticarcillin