[Activity of amoxicillin and ampicillin against infection with Salmonella typhimurium in mice ].
Experimental mouse intraperitoneal or intragastric infection due to Salmonella typhimurium C5 was treated with subcutaneous amoxicillin or ampicillin. The minimum inhibitory concentrations (MIC) and the minimum bactericidal concentrations (MBC) of the two penicillins were similar. Amoxicillin was significantly more effective than ampicillin in protecting the animals from the lethal effects of the infection. The enumeration of bacteria from spleen and Peyer's patches of the small intestine showed that amoxicillin killed S. typhimurium faster than ampicillin.
D000658:Amoxicillin / Q000627:therapeutic use*; D000667:Ampicillin / Q000627:therapeutic use*; D000818:Animals; D001433:Bacteriolysis; D005260:Female; D051379:Mice; D010581:Peyer's Patches / Q000382:microbiology; D012481:Salmonella Infections, Animal / Q000188:drug therapy*; D012486:Salmonella typhimurium / Q000302:isolation & purification; D013154:Spleen / Q000382:microbiology
D000667:Ampicillin; D000658:Amoxicillin
Comparaison de l'ampicilline et de l'amoxicilline comme traitement de l'infection expérimentale de la souris par Salmonella typhimurium.