Evidence that a 'critical period' is involved in early estrogen-induced LH- and FSH-release during the estrous cycle in the rat.
LH- and FSH-release, which occurred in the afternoon of diestrus 1 following estradiol benzoate administration in the morning of estrus, was completely prevented by pentobarbital, when injected on diestrus 1 at 13.30 h.
D000818:Animals; D002369:Castration; D004958:Estradiol / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000378:metabolism*; D010424:Pentobarbital / Q000494:pharmacology; D011247:Pregnancy; D051381:Rats; D013997:Time Factors
D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D010424:Pentobarbital