Minimal within-day variation of high density lipoprotein cholesterol and apolipoprotein A-I levels in normal subjects.
Blood was drawn from twenty normal hospital employees after a 12-14 hr fast (9:30 AM), and at 4 hr (1:30 PM) and 7 hr (4:30 PM) thereafter while test subjects consumed their habitual diet. Absorptive chylomicronemia was reflected in average triglyceride increases of 30% and 53% at 4 hr and 7 hr, respectively. No significant changes in total (< 1%) and high density lipoprotein (< 0.1%) cholesterol concentrations were observed. Moreover, levels of the major high density lipoprotein apolipoprotein, apoA-I, varied by less than 3%. Blood samples, randomly obtained during standard working hours, appear adequate for quantitation of high density lipoprotein cholesterol and apolipoprotein A-I levels.
D016632:Apolipoprotein A-I; D001053:Apolipoproteins / Q000097:blood*; D002784:Cholesterol / Q000097:blood*; D002914:Chylomicrons / Q000097:blood; D002940:Circadian Rhythm; D006801:Humans; D008075:Lipoproteins, HDL / Q000097:blood; D014280:Triglycerides / Q000097:blood
D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D002914:Chylomicrons; D008075:Lipoproteins, HDL; D014280:Triglycerides; D002784:Cholesterol