Single extra-amniotic injection of prostaglandin E2 in Tylose gel to induce first trimester abortion in young nullipara.
A single extra-amniotic injection of 2 or 4 mg of prostaglandin E2 in Tylose gel was administered to 30 primigravidae between the ages of 14 and 20 years to induce first-trimester abortion. Twenty-three patients (76.7%) aborted, though incompletely, within 9 hours, with a mean induction-abortion interval of 6.3 hours. In the remaining 7 (23.3%) the cervical os was found to be open and no mechanical dilatation was required at the time of vacuum aspiration. The only side effect was vomiting, which occurred in 2 patients. The method was shown to be safe and effective and may be employed in young primigravidae, thus eliminating the cervical complications attending vacuum aspiration.
D000028:Abortion, Induced; D000293:Adolescent; D000328:Adult; D000650:Amnion; D002986:Clinical Trials as Topic; D015232:Dinoprostone; D005260:Female; D005782:Gels; D006801:Humans; D007267:Injections; D010298:Parity; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011458:Prostaglandins E / Q000008:administration & dosage*
D005782:Gels; D011458:Prostaglandins E; D015232:Dinoprostone