The effect of topical l-epinephrine on regional ocular blood flow in monkeys.
A 25 microliter volume of a 1-% l-epinephrine borate solution applied on the cornea of one eye in 12 monkeys reduced blood flow through the iris and the ciliary body by 59% and 20%, respectively, compared to the untreated control eyes. In the ciliary body the main effect was in the ciliary processes. Blood flow was determined with the labeled microsphere method 1, 4, and 6 hr after application of the drug. The average blood flow reductions were of the same order in the three groups, indicating a duration of at least 6 hr. No effect on blood flow through the retina or the choroid was observed.
D000287:Administration, Topical; D000818:Animals; D002521:Cercopithecus; D002924:Ciliary Body / Q000098:blood supply / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology*; D005260:Female; D000882:Haplorhini; D007498:Iris / Q000098:blood supply / Q000187:drug effects*; D008252:Macaca fascicularis; D008297:Male; D008863:Microspheres; D012039:Regional Blood Flow / Q000187:drug effects
D004837:Epinephrine