Effect of glucagon infusion on some plasma metabolites and hormones in obese children.
The metabolic and hormonal effects of glucagon infusion (6 micrograms/kg/h) for three hours were studied in obese children. Glucagon caused a sustained hyperglycaemia and hyperinsulinaemia and a lower than normal (non-obese) growth hormone response. Plasma triglycerides, cholesterol, glycerol and the majority of the free amino acids showed a significant decrease in comparison with the controls, while free fatty acids showed a moderate decrease. Glucagon administration revealed some hormonal and metabolic abnormalities of obesity. The effect of glucagon-induced insulin secretion and the action of pharmacologic doses of glucagon have, however, to be considered in the interpretation of the metabolic effect of glucagon.
D000596:Amino Acids / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D002784:Cholesterol / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005934:Glucagon / Q000494:pharmacology*; D005990:Glycerol / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D009765:Obesity / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid; D013268:Stimulation, Chemical; D014280:Triglycerides / Q000378:metabolism
D000596:Amino Acids; D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007773:Lactates; D011773:Pyruvates; D014280:Triglycerides; D019344:Lactic Acid; D019289:Pyruvic Acid; D013006:Growth Hormone; D005934:Glucagon; D002784:Cholesterol; D005990:Glycerol