The metabolic fate of [14C] benzoic acid in protein-energy deficient rats.
The metabolic fate of [14C] benzoic acid administered i.p. to marasmic-kwashiorkor rats has been investigated. Rats fed a normal diet with benzoic acid administered i.p. at 200 mg/kg, excreted the benzoic acid mainly as hippuric acid (99% of 24 h excretion), while marasmic-kwashiorkor rats excreted 62--85% as hippuric acid and 14--37% as the glucuronide conjugate. 2 weeks after repletion metabolism of benzoic acid by the marasmic-kwashiorkor rats on the stock diet had returned to normal; most of the benzoate was excreted as hippuric acid.
D000818:Animals; D001565:Benzoates / Q000378:metabolism* / Q000652:urine; D002854:Chromatography, Paper; D005965:Glucuronates / Q000652:urine; D006626:Hippurates / Q000652:urine; D007732:Kwashiorkor / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D011502:Protein-Energy Malnutrition / Q000378:metabolism*; D051381:Rats
D001565:Benzoates; D005965:Glucuronates; D006626:Hippurates