Insulin binding to erythrocytes after acute 16-methyleneprednisolone ingestion.
The binding of [125I]insulin to erythrocytes, glucose and insulin were determined before and 1, 7 and 35 days after ingestion of 2 X 60-methyleneprednisolone. None of two groups of volunteers (7 males, 4 females showed clear alterations of the insulin binding parameters (Ka and R0), or of the fasting cortisol, glucose and insulin concentrations. These results exclude the possibility that the diabetogenic effect of glucocorticoides is accompanied by an alteration of the insulin receptor characteristics of erythrocytes.
D001786:Blood Glucose / Q000378:metabolism; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood*; D007700:Kinetics; D008297:Male; D011239:Prednisolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D011972:Receptor, Insulin / Q000378:metabolism; D012737:Sex Factors; D013997:Time Factors
D001786:Blood Glucose; D007328:Insulin; D011239:Prednisolone; D011972:Receptor, Insulin; C036266:prednylidene; D006854:Hydrocortisone