Platelet adsorption-source of error in reference controls.
Preparation of platelet reference controls requires that the platelet membranes be strengthened by chemical cross-linking, usually with glutaraldehyde. The reaction produces a platelet which is strongly absorbed to plastic and glass surfaces. Tests of commercially available reference controls indicate adsorption to the counting containers. Surfactants inhibit adsorption but cause an apparent decrease in size. Polyethylene glyocol can eliminate adsorption without altering conductivity.
D000447:Aldehydes / Q000494:pharmacology*; D003432:Cross-Linking Reagents / Q000494:pharmacology; D005976:Glutaral / Q000494:pharmacology*; D010969:Plastics; D010973:Platelet Adhesiveness / Q000187:drug effects*; D010976:Platelet Count; D012015:Reference Standards; D013499:Surface Properties; D013501:Surface-Active Agents / Q000494:pharmacology
D000447:Aldehydes; D003432:Cross-Linking Reagents; D010969:Plastics; D013501:Surface-Active Agents; D005976:Glutaral