Changes in blood-brain permeability resulting from D-amphetamine, 6-hydroxydopamine and pimozide measured by a new technique.
A new technique is described for measurement of diffusion across the blood-brain barrier using intraventricularly administered 68Ga-EDTA, and determining loss from the brain with a scintillation camera. Repeated injections via permanent cannulas showed that the diffusion half-time was reduced to 50% of control values after intraventricular d-amphetamine and 6-hydroxydopamine; pimozide had no effect.
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003913:Dextroamphetamine / Q000494:pharmacology*; D004492:Edetic Acid; D005710:Gallium Radioisotopes; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D010868:Pimozide / Q000494:pharmacology*; D051381:Rats
D005710:Gallium Radioisotopes; D006892:Hydroxydopamines; D010868:Pimozide; D004492:Edetic Acid; D003913:Dextroamphetamine