Developmental change and hormonal control of beta-glucosidase activity in rat kidney.
beta-Glucosidase activity in rat kidney increased progressively with age, from 4 weeks after birth up to 52 weeks. A marked sexual difference in enzyme activity was found in the adult kidney. The activity in adult males was 1.4--2.1 times higher than in adult females. Castration of males decreased the beta-glucosidase activity to an about normal female level and the decreased activity returned to a normal male level following injeciton of testosterone. Ovariectomy did not affect enzyme activity. Adrenalectomy decreased enzyme activity to about 50% of the normal level in both males and females and the decreased activity returned to a normal level following injection of hydrocortisone.
D000315:Adrenalectomy; D000818:Animals; D002369:Castration; D005260:Female; D005959:Glucosidases / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology*; D007525:Isoelectric Focusing; D007668:Kidney / Q000201:enzymology* / Q000254:growth & development; D008297:Male; D011506:Proteins / Q000032:analysis; D051381:Rats; D001617:beta-Glucosidase / Q000378:metabolism*
D011506:Proteins; D005959:Glucosidases; D001617:beta-Glucosidase; D006854:Hydrocortisone