Carnitine in human nutrition.
The oxidation of long-chain fatty acids is carnitine-dependent. Indeed, only when they are bound to carnitine, in the form of acyl-carnitines, do fatty acids penetrate into the mitochondria to be oxidized. To meet the need for carnitine, animals depend on both endogenous synthesis and an exogenous supply. A diet rich in meat supplies a lot of carnitine, while vegetables, fruits, and grains furnish relatively little. Although it has a low molecular weight and acts at low doses in a vital metabolic pathway, carnitine should not be considered a vitamin, but rather a nutritive substance. Indeed, it seems that the diet of the adult human need not necessarily furnish carnitine: the healthy organism, given a balanced nutrition (sufficiently rich in lysine and methionine), may well be able to meet all its needs. Furthermore, it seems that a reduction of the exogenous supply of carnitine results in a lowering of its elimination in the urine. However, dietary carnitine is more important during the neonatal period. The transition from fetal to extrauterine life is accompanied by an increased role of lipids in meeting energy needs. This change is accompanied by a rise in the body of the levels of carnitine, which is mainly supplied in the maternal milk. Finally, this review briefly surveys the illnesses in which a dietary carnitine supplement proves useful.
D000818:Animals; D001682:Biological Availability; D002331:Carnitine / Q000032:analysis / Q000378:metabolism* / Q000627:therapeutic use; D055598:Chemical Phenomena; D002621:Chemistry; D004032:Diet; D006801:Humans; D007408:Intestinal Absorption; D050356:Lipid Metabolism; D008460:Meat / Q000032:analysis; D009747:Nutritional Physiological Phenomena; D009751:Nutritional Requirements
D002331:Carnitine