The experimental induction of ultrastructural damage in cardiac muscle.
Experimentally-induced rises in intracellular calcium ([Ca2+]i) promote rapid myofilament degradation in amphibian and mammalian cardiac muscle strips. The relevance of these studies to the subcellular injury produced by ischaemia, the possible involvement of lysosomal enzymes and similarities with skeletal muscle are discussed.
D000818:Animals; D000001:Calcimycin / Q000633:toxicity; D002118:Calcium / Q000502:physiology; D003327:Coronary Disease / Q000473:pathology; D004140:Dinitrophenols / Q000633:toxicity; D006321:Heart / Q000187:drug effects; D066298:In Vitro Techniques; D051379:Mice; D009132:Muscles / Q000187:drug effects; D009206:Myocardium / Q000648:ultrastructure*; D011896:Rana temporaria
D004140:Dinitrophenols; D000001:Calcimycin; D002118:Calcium