Halothane anesthesia and aqueous humor dynamics in laboratory animals.
Halothane anesthesia decreased intraocular pressure (IOP) by approximately 4 mm Hg in both normal rabbits and monkeys. The administration of nitrous oxide or 100% oxygen had no effect on IOP. Although PO2 and PCO2 increased following halothane administration in rabbits, similar blood changes occurred without IOP reduction in control rabbits receiving 100% oxygen. Outflow facility in both species as measured by tonography remained unchanged by halothane administration. Aqueous humor flow as estimated by tonography decreased by about 39% in rabbits and 31% in monkeys. Posterior chamber aqueous humor ascorbate was significantly elevated 90 min after halothane administration in rabbits. The ratio of the aqueous humor flow coefficient to diffusion coefficient for ascorbate (kfa/kdpa) was reduced approximately 47% following the administration of halothane. Halothane did not alter the in vitro accumulation of 131I-hippuran or 86Rb by rabbit ciliary body--iris preparations.
D000769:Anesthesia, Inhalation; D000818:Animals; D001082:Aqueous Humor / Q000032:analysis / Q000187:drug effects*; D001205:Ascorbic Acid / Q000032:analysis; D001784:Blood Gas Analysis; D002924:Ciliary Body / Q000378:metabolism; D004058:Diffusion; D006221:Halothane / Q000494:pharmacology*; D000882:Haplorhini; D066298:In Vitro Techniques; D007429:Intraocular Pressure / Q000187:drug effects*; D007498:Iris / Q000378:metabolism; D008253:Macaca mulatta; D008297:Male; D011817:Rabbits; D014065:Tonometry, Ocular
D001205:Ascorbic Acid; D006221:Halothane