[Anticentromere antibodies. Diagnostic and prognostic value].
The results of investigations for antinuclear antibodies in scleroderma and other connective diseases are reported. An indirect fluorescence method on Hep-2 cell smears was used. Antibodies directed against chromosomal centromeres were detected in 25 cases: 19 sera of patients with diffuse scleroderma, 2 cases of Raynaud's disease, 2 cases of rheumatoid arthritis and 1 case each of lupus and dermatomyositis. A significant correlation was found between the presence of anticentromere antibodies and benign forms of scleroderma, notably the CREST syndrome.
D000974:Antibodies, Antinuclear / Q000032:analysis*; D001172:Arthritis, Rheumatoid / Q000276:immunology; D002503:Centromere / Q000276:immunology*; D002875:Chromosomes / Q000276:immunology*; D002999:Clone Cells; D003095:Collagen Diseases / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D011379:Prognosis; D011928:Raynaud Disease / Q000276:immunology; D012595:Scleroderma, Systemic / Q000175:diagnosis*
D000974:Antibodies, Antinuclear
Les anticorps anticentromère. Valeur diagnostique et pronostique.