Putrescine catabolism in rats given heparin or aminoguanidine.
Rats treated acutely with aminoguanidine, a potent inhibitor of diamine oxidase, or with heparin display reduced ability to metabolize 14C-putrescine to radioactive carbon dioxide. After either drug rats recover 50% of the ability to catabolize putrescine in 15--18 h. This is in close agreement with the half-time for recovery of diamine exidase activity, and indicates that putrecine-catabolizing ability of the rat reflects in a physiologically significant way the function of diamine oxidase in vivo.
D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006146:Guanidines / Q000378:metabolism / Q000494:pharmacology*; D006493:Heparin / Q000494:pharmacology*; D007421:Intestine, Small / Q000201:enzymology; D008297:Male; D011700:Putrescine / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D006146:Guanidines; D006493:Heparin; D006631:Amine Oxidase (Copper-Containing); C004479:pimagedine; D011700:Putrescine