[Logical use of prophylactic antibacterial agents in infectious post-appendectomy complications. A controlled clinical trial].
A prospective clinical trial is carried out in 88 patients undergoing surgery for removal of the appendix. Authors show the efficacy of the association of pre and postoperative gentamycin plus clindamycin or lincomycin in prevention of postoperative infections, which, in the cases with non-ruptured appendix was 0%, and in gangrenous or perforated cases was 8.6%, with a global infection rate of 6% in this prophylactic subgroup I. However, when the same antibiotics are administered only postoperatively (subgroup II), global infection rate is of 34.2% similar to data in the literature in which no antibiotics were given. There have been no complications derived from this antibiotic prophylaxis.
D001062:Appendectomy; D001064:Appendicitis / Q000473:pathology / Q000601:surgery; D001424:Bacterial Infections / Q000517:prevention & control*; D002648:Child; D002981:Clindamycin / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D005734:Gangrene; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D008034:Lincomycin / Q000627:therapeutic use*; D008297:Male; D011183:Postoperative Complications / Q000517:prevention & control*; D012422:Rupture, Spontaneous
D005839:Gentamicins; D002981:Clindamycin; D008034:Lincomycin
Uso lógico de antimicrobianos profilácticos en las complicaciones infecciosas post-apendicectomía. Estudio clínico controlado.