[Effects of lesions of the anterior raphe nuclei on the self-administration of d-amphetamine in the rat : considerable increase of desire for the poison].
The acquisition of the intravenous self-administration of d-amphetamine was studied after separate lesions of anterior raphe nuclei (dorsal or median). Every lever-press delivered 2.5 microliter of a d-amphetamine solution dosed at 7.5 microgram/kg. Lesion of anterior raphe nuclei produced an hyper-sensitivity to d-amphetamine as indicated by a dramatic increase in self-administration by experimental Rats compared to the controls. Moreover this enhanced self-administration behavior is observed with a low blood concentration of d-amphetamine. The greater increase was obtained for median raphe lesioned Rats. These effects are interpreted in terms of 5HT-DA balance and could provide an experimental model for neurobiological bases of drug addiction studies.
D000818:Animals; D001933:Brain Stem / Q000502:physiology*; D003913:Dextroamphetamine / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D011903:Raphe Nuclei / Q000502:physiology*; D051381:Rats; D012646:Self Administration; D019966:Substance-Related Disorders / Q000209:etiology
D003913:Dextroamphetamine
Effets de la lésion des noyaux du raphé sur l'autoadministration de d-amphétamine chez le rat : augmentation considérable de l'appétence au toxique.