Inhibition of mutagenicity of a model nitrosation reaction by naturally occurring phenolics, coffee and tea.
Several plant phenolics, one instant coffee, one instant decaffeinated coffee, one roasted coffee, one Japanese tea, one black Indian tea, and one Chinese tea were examined for their inhibitory properties on mutagenicity resulting from the nitrosation of methylurea. Mutagenicity was estimated as the number of his+ revertants per survivor of Salmonella typhimurium TA1535 which was exposed in suspension to the nitrosation mixtures and the modulating agents for 20 min. Tannic acid, gallic acid and chlorogenic acid suppressed the mutagenicity of the model nitrosation system at concentrations similar to or even lower than ascorbic acid. The three tested coffees and three tested teas exerted an inhibitory effect on the mutagenicity of the test system at doses at which they are consumed.
D002726:Chlorogenic Acid / Q000494:pharmacology; D003069:Coffee; D005707:Gallic Acid / Q000494:pharmacology; D006639:Histidine / Q000235:genetics; D047348:Hydrolyzable Tannins / Q000494:pharmacology; D008782:Methylurea Compounds / Q000378:metabolism / Q000494:pharmacology; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000235:genetics; D013662:Tea
D003069:Coffee; D047348:Hydrolyzable Tannins; D008782:Methylurea Compounds; D009153:Mutagens; D010936:Plant Extracts; D013662:Tea; D002726:Chlorogenic Acid; D006639:Histidine; D005707:Gallic Acid; C002352:methylurea