The action of 7-N-(p-hydroxyphenyl)mitomycin C [M-83] in suppressing murine immune response.
The immuno-suppressive activities of 7-N-(p-hydroxyphenyl)mitomycin C [M-83], a derivative of mitomycin C (MMC), which has better antitumor activity against murine tumors, was investigated in mice. A single injection of M-83 induced an apparent but relatively transient reduction in both plaque-forming cell production and delayed type hypersensitivity reaction to sheep red blood cells. The suppressive effect of M-83 was significantly milder than that of MMC at the same effective and molar equivalent doses. Moreover, the recovery from immunosuppression induced by M-83 was also relatively rapid as compared with MMC. The inhibiting activity of M-83 against the blastogenic response of spleen cells was milder in vivo, but was more significantly cytotoxic in vitro than that of MMC.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D006462:Hemolytic Plaque Technique; D006968:Hypersensitivity, Delayed / Q000517:prevention & control; D007166:Immunosuppressive Agents; D007941:Leukemia P388 / Q000188:drug therapy; D008213:Lymphocyte Activation / Q000187:drug effects; D051379:Mice; D008815:Mice, Inbred Strains; D016685:Mitomycin; D008937:Mitomycins / Q000378:metabolism / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D007166:Immunosuppressive Agents; D008937:Mitomycins; D016685:Mitomycin; C027281:7-N-(4-hydroxyphenyl)mitomycin C