Gold does not alter the arthritic, humoral, or cellular responses in rats with type II collagen-induced arthritis.
We assessed the effects of administration of gold sodium thiomalate on the clinical and immunologic manifestations of type II collagen-induced arthritis in rats. Injections of varying doses of gold did not alter these parameters significantly. Thus, there was no evidence in this animal model that gold possesses either antiinflammatory or immunosuppressive properties.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001168:Arthritis / Q000139:chemically induced* / Q000175:diagnosis; D003094:Collagen; D005260:Female; D006046:Gold / Q000097:blood; D006052:Gold Sodium Thiomalate / Q000494:pharmacology*; D006388:Hemagglutinins; D006968:Hypersensitivity, Delayed / Q000175:diagnosis; D007111:Immunity, Cellular / Q000187:drug effects*; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis; D051381:Rats
D006388:Hemagglutinins; D007961:Leukocyte Migration-Inhibitory Factors; D006052:Gold Sodium Thiomalate; D006046:Gold; D003094:Collagen