Clinical trials: some reflections.
The principles and historical development of clinical trials are outlined briefly. Some issues that extend the basic philosophy first put forward by Sir Austin Bradford Hill 40 years ago and that will need consideration in the future application of clinical trials are discussed.
D002986:Clinical Trials as Topic; D004739:England; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D012107:Research Design; D013223:Statistics as Topic