Two blind randomized cross-over trials in the treatment of primary open angle glaucoma.
We present the results of two blind randomized trials comparing both guanethidine 3 per cent and adrenaline 0.5 per cent (Ganda 3.0/0.5) and guanethidine 1 per cent and adrenaline 0.2 per cent (Ganda 1.0/0.2) in single drop form with Timolol (Timoptol) 0.25 per cent. Results of 48-hour phasing at the end of one month's treatment demonstrated a significantly greater fall in intraocular pressure with Ganda 3.0/0.5 (9.8 mm Hg) than with Timolol 0.25 per cent (7.67 mm Hg) P less than 0.001. There was no significant difference in the fall in intraocular pressure between Ganda 1.0/0.2 (8.87 mm Hg) and Timolol 0.25 per cent (8.24 mm Hg).
D000368:Aged; D002986:Clinical Trials as Topic; D004338:Drug Combinations; D004359:Drug Therapy, Combination; D004837:Epinephrine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy* / Q000503:physiopathology; D006145:Guanethidine / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011412:Propanolamines / Q000627:therapeutic use*; D011897:Random Allocation; D013999:Timolol / Q000009:adverse effects / Q000627:therapeutic use*
D004338:Drug Combinations; D011412:Propanolamines; D013999:Timolol; D004837:Epinephrine; D006145:Guanethidine