The kinetics of haemopoietic differentiation assessed by in vitro bone marrow culture in endotoxin-treated and in anaemic calves.
Marrow aspirates from calves injected with Pseudomonas aeruginosa endotoxin showed an increased number of granulocyte/macrophage progenitor cells, and a reduced number of erythroid progenitor cells. On the other hand, marrow aspirates from calves made anaemic by repeated phlebotomy showed an increased number of erythroid progenitor cells, and a reduced number of granulocyte/macrophage progenitor cells. These observations were interpreted as evidence of stem cell erythroid-granuloid directional competition occurring in response to the need for a particular cell type.
D000740:Anemia / Q000097:blood / Q000662:veterinary*; D000818:Animals; D001854:Bone Marrow Cells; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood*; D003114:Colony-Forming Units Assay; D004731:Endotoxins / Q000633:toxicity*; D006400:Hematocrit; D006410:Hematopoiesis; D006454:Hemoglobins / Q000032:analysis; D011550:Pseudomonas aeruginosa
D004731:Endotoxins; D006454:Hemoglobins