Prostaglandin E1-induced glucagon secretion under propranolol treatment in a case of idiopathic hyperglucagonemia.
To see how prostaglandin E1 (PGE1) directly effects on the islet cells, PGE1 (200 ng/min) was infused into the celiac artery for 10 min in a patient with idiopathic hyperglucagonemia pretreated with propranolol (80 mg/day, for 5 days). Plasma immunoreactive glucagon (IRG), which had been suppressed to 568 pg/ml by the pretreatment, increased to 1,358 pg/ml at the end of infusion, and it remained over the basal value for 30 min. Plasma immunoreactive insulin (IRI) reached maximum at 5 min and decreased thereafter. These results suggest the possibility of the stimulatory effects of PGE1, not mediated by beta-adrenergic system, on glucagon secretion from alpha cells.
D000328:Adult; D000527:Alprostadil; D005260:Female; D005934:Glucagon / Q000097:blood*; D006801:Humans; D007261:Infusions, Intra-Arterial; D007328:Insulin / Q000097:blood; D011433:Propranolol / Q000627:therapeutic use*; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology*
D007328:Insulin; D011458:Prostaglandins E; D005934:Glucagon; D011433:Propranolol; D000527:Alprostadil