3-Hydrazinopyridazine derivatives as inhibitors of pyridoxal-phosphate dependent enzymes.
A series 3-hydrazinopyridazine derivatives with anti-hypertensive properties was studied as inhibitors of pyridoxal-phosphate dependent enzymes. All the compounds with a free hydrazino group were found to be strong inhibitors in vitro. In vivo inactive compounds became active at doses which exert a hypotensive action. The significance of this inhibition is discussed.
D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors; D000818:Animals; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D001219:Aspartate Aminotransferases / Q000037:antagonists & inhibitors; D001794:Blood Pressure / Q000187:drug effects; D004791:Enzyme Inhibitors; D005260:Female; D006834:Hydrazines / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D011724:Pyridazines / Q000494:pharmacology*; D011732:Pyridoxal Phosphate / Q000378:metabolism*; D051381:Rats
D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D004791:Enzyme Inhibitors; D006834:Hydrazines; D011724:Pyridazines; D011732:Pyridoxal Phosphate; D006631:Amine Oxidase (Copper-Containing); D001219:Aspartate Aminotransferases