Biochemical changes associated with severe trauma.
The effects of different intravenous nutritional regimens on a number of biochemical indices of nutritional status were studied during the 8-day period following severe trauma. The inclusion of large amounts of amino acids (high nitrogen (N) was shown to greatly improve N balance over an isocaloric regimen containing no amino acids (O g N). The concentration of serum albumin, transferrin, prealbumin, and retinol-binding protein all fell during the study period in both patient groups, whereas the serum concentrations of acute phase reactants and of ribonuclease increased in the two groups. The sum of plasma levels of branched-chain amino acids and the essential amino acids was increased to a greater extent in the high N group. These amino acid totals and the ratio of glycine/valine showed a significant correlation with N balance in this group. Despite the marked difference in N balance, 3-methylhistidine excretion was increased but equal in the two nutritional groups, suggesting an increased rate of muscle protein breakdown in both groups, which appears not to be influenced by amino acid nutrition. It is concluded that N balance can be significantly improved in the immediate posttrauma period by provision of amino acids together with energy substrates. None of the biochemical variables measured, with the exception of plasma levels of essential amino acids, reflected these marked differences in N balance.
D000328:Adult; D000596:Amino Acids / Q000494:pharmacology*; D000597:Amino Acids, Branched-Chain / Q000097:blood; D000601:Amino Acids, Essential / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism; D002056:Burns / Q000378:metabolism; D003401:Creatine / Q000652:urine; D050723:Fractures, Bone / Q000378:metabolism; D006801:Humans; D008762:Methylhistidines / Q000652:urine; D008875:Middle Aged; D009584:Nitrogen / Q000378:metabolism*; D010288:Parenteral Nutrition / Q000592:standards*; D014947:Wounds and Injuries / Q000378:metabolism*
D000596:Amino Acids; D000597:Amino Acids, Branched-Chain; D000601:Amino Acids, Essential; D001798:Blood Proteins; D008762:Methylhistidines; D003401:Creatine; D009584:Nitrogen