Recurring thrombo-embolic accidents caused by family-related deficiency of the fibrinolysis system.
Several members of the same family underwent examinations on the coagulation and fibrinolysis systems after recurring thrombo-embolic disease was observed in one of the members of the family. The results of biological examinations revealed normal coagulation factors, but a high level of plasminogen activation inhibitors accompanied by an increase in platelet aggregation was observed. These results are compared with the few similar cases reported by other authors. The exact part played in this particular case by the platelets and the inhibitor in the patient's predisposition to venous thrombosis and the spread of the disease is discussed. It would seem that the platelet abnormality merely accompanys the increase in inhibitors which is passed on by recessive autosomal transmission. The authors consider that in all cases of thrombosis, particularly recurring thrombosis, an investigation, comprising a study of the fibrinolysis factors and particularly the inhibitors, must be carried out on the patient's close family.
D000328:Adult; D000368:Aged; D001778:Blood Coagulation Disorders / Q000235:genetics*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010375:Pedigree; D010960:Plasminogen Activators / Q000037:antagonists & inhibitors*; D015849:Plasminogen Inactivators; D010974:Platelet Aggregation; D011655:Pulmonary Embolism / Q000209:etiology; D012008:Recurrence; D013923:Thromboembolism / Q000209:etiology / Q000235:genetics*
D015849:Plasminogen Inactivators; D010960:Plasminogen Activators