Blood flow and reactivity to noradrenaline in DMBA-induced rat mammary neoplasia.
Blood flow during "resting condition' and during noradrenaline infusion were studied by microsphere tracer technique in DMBA-induced mammary tumors, hindpaw, muscle and liver in rats. During "resting condition' the mean tumor blood flow was relatively high and in the same range as that of the hindpaw representing mainly skinflow, but during noradrenaline infusion there was a marked decrease in tumor blood flow as was the case for hindpaw, while cardiac output, muscle flow and arterial liver flow remained essentially unaltered. There was an inverse relation between tumor size and blood flow.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001551:Benz(a)Anthracenes; D001775:Blood Circulation / Q000187:drug effects*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D008102:Liver Circulation / Q000187:drug effects; D008325:Mammary Neoplasms, Experimental / Q000098:blood supply* / Q000139:chemically induced; D009132:Muscles / Q000098:blood supply; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D012867:Skin / Q000098:blood supply
D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene; D009638:Norepinephrine