The prevention of cyclophosphamide-induced bladder swelling in the rat by I.V. administration of sodium-2-mercaptoethane sulfonate.
In a preliminary experiment the wet weight of the rat urinary bladder appeared to correlate with cyclophosphamide toxicity. The effect of a proposed antidote (SMES), given on various time schedules, was studied using the wet weight as a measure of toxicity. At a cose of 20 mg/kg/SMES it was found to neutralize the toxicity of 100 mg cytoxan only when given simultaneously. It is suggested that this model might be used in further studies.
D000818:Animals; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors*; D007275:Injections, Intravenous; D008623:Mercaptoethanol / Q000031:analogs & derivatives*; D015080:Mesna / Q000008:administration & dosage / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D001743:Urinary Bladder / Q000187:drug effects*
D008623:Mercaptoethanol; D003520:Cyclophosphamide; D015080:Mesna