Anti-A haemagglutinins in factor VIII concentrates.
Experimental evidence has been obtained that cryoprecipitation concentrates anti-A in mixtures of group O and group A plasma by a mechanism that does not operate in group O plasma alone. It has been concluded that the anti-A/A polysaccharide complex is less soluble during cryoprecipitation than anti-A immunoglobulin, and this complex dissociates to give free anti-A when the cryoprecipitate is redissolved. From a practical point of view, factor VIII concentrates prepared from cryoprecipitate obtained from single donations of plasma unselected for ABO group contain significantly less anti-A than those prepared from mixing pools of plasma in which partial neutralisation of anti-A has occurred before cryoprecipitation.
D000017:ABO Blood-Group System / Q000276:immunology*; D001793:Blood Preservation / Q000379:methods; D011232:Chemical Precipitation; D005169:Factor VIII / Q000276:immunology*; D005615:Freezing; D006388:Hemagglutinins / Q000032:analysis*; D006801:Humans; D007518:Isoantibodies / Q000032:analysis*
D000017:ABO Blood-Group System; D006388:Hemagglutinins; D007518:Isoantibodies; D005169:Factor VIII