Influence of manganese ions on the contraction of the guinea-pig isolated vas deferens.
1. The CaCl2-induced contraction of guinea-pig isolated vas deferens, pretreated with tetrasodium edetate and then transferred to edetate-free sucrose medium, was increased in the presence of MnCl2 in extremely low concentrations (0.005-0.01 mmol/l) but was suppressed by the salt in concentrations higher than 1.0 mmol/l. 2. The KCl-induced contraction of the preparation, kept in a sucrose medium without edetate-pretreatment, was suppressed by MnCl2 (0.005-0.5 mmol/l) in a concentration-dependent manner. 3. The noradrenaline-induced contraction of the preparation kept in Locke's solution, was not influenced by MnCl2 in concentrations lower tha 0.1 mmol/l but was inhibited by higher concentrations (0.1-1.0 mmol/l).
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D004492:Edetic Acid / Q000494:pharmacology; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008297:Male; D008345:Manganese / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D014649:Vas Deferens / Q000187:drug effects
D008345:Manganese; D004492:Edetic Acid; D011188:Potassium; D002118:Calcium; D009638:Norepinephrine