Acute exposure of rhesus monkeys to DDT: effect on carbohydrate metabolism.
The administration of a single oral dose of DDT (150 mg/kg body wt.) to rhesus monkey elevated the hepatic glycogen and glycogen synthase activity but depressed the glycogen phosphorylase activity. A decrease in adenylate cyclase, both basal as well as fluoride and norepinephrine stimulated activity, was observed in liver of DDT-treated animals as compared to controls. Gluconeogenic enzymes did not record any significant change in the liver.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D050260:Carbohydrate Metabolism; D003634:DDT / Q000494:pharmacology*; D000882:Haplorhini; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008112:Liver Glycogen / Q000378:metabolism; D008253:Macaca mulatta; D008297:Male
D008112:Liver Glycogen; D003634:DDT; D000262:Adenylyl Cyclases