Nonenzymatic chloramphenicol resistance determinants specified by plasmids R26 and R55-1 in Escherichia coli K-12 do not confer high-level resistance to fluorinated analogs.
Plasmids R26 (Inc P) and R55-1 (Inc C) specify inducible nonenzymatic resistance to chloramphenicol. Escherichia coli K-12 strains harboring these plasmids encoded low-level resistance to thiamphenicol analogs Sch 25298 and Sch 25393 but failed to specify resistance to the fluorinated chloramphenicol analog Sch 24893. The analogs were efficient inducers of high-level chloramphenicol resistance.
D002701:Chloramphenicol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D011815:R Factors; D013839:Thiamphenicol / Q000031:analogs & derivatives / Q000494:pharmacology
D002701:Chloramphenicol; C035533:Sch 25393; C035535:3-fluorochloramphenicol; C035534:florfenicol; D013839:Thiamphenicol