Pseudomonas aeruginosa infection and vaccination in the rat.
A large molecular-weight fraction of Pseudomonas aeruginosa culture filtrate protected rats and mice against a lethal infection with a heterologous serotype, and to some extent against Escherichia coli and Listeria monocytogenes. The active components were obtained from cultures grown for several days in a simple synthetic medium. Infection and vaccination with P. aeruginosa serotype 16 induced agglutinating and precipitating antibodies to the components of this serotype only; in rats infected or vaccinated with serotype 1, low titres of agglutinating antibody against type 16 were found. Vaccine prepared from type 1 or 16 increased, within 3 days of infection, the resistance of rats to type-16 organisms; within the same period agglutinins or precipitins were not produced. It is possible that the protection was based on opsonic and antitoxic activities.
D000373:Agglutinins; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D001428:Bacterial Vaccines / Q000276:immunology*; D004927:Escherichia coli Infections / Q000276:immunology; D005260:Female; D006968:Hypersensitivity, Delayed; D007958:Leukocyte Count; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D011234:Precipitins; D011552:Pseudomonas Infections / Q000276:immunology*; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D051381:Rats; D014611:Vaccination
D000373:Agglutinins; D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D011234:Precipitins