In utero alcohol exposure and developmental delay of response inhibition.
Offspring of rats fed liquid alcohol diet during pregnancy exhibited age-related increased activity and deficits in passive avoidance learning and response perseveration which were not age-related. Alcohol-exposed offspring also elicited less maternal responsiveness from nontreated dams than did pair-fed controls. The results suggest that in utero alcohol exposure produces a developmental delay in ontogeny of response inhibition mechanisms underlying activity, but not passive avoidance learning or spontaneous alternation.
D000428:Alcohol Drinking; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004193:Discrimination Learning / Q000187:drug effects; D000431:Ethanol / Q000097:blood; D005260:Female; D008431:Maternal-Fetal Exchange / Q000187:drug effects*; D011939:Mental Recall / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects; D009115:Muridae; D011247:Pregnancy
D000431:Ethanol