CSF GABA in psychotic disorders.
CSF GABA levels were not significantly different in a group of drug-free psychotic patients compared to a group of psychotic patients at two points during haloperidol treatment or a neurological comparison group. In the untreated group, CSF GABA was significantly negatively correlated with clinical ratings of anxiety and agitation. Early in haloperidol treatment CSF GABA was significantly positively correlated with CSF HVA.
D000293:Adolescent; D000328:Adult; D005260:Female; D006220:Haloperidol / Q000627:therapeutic use; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D008297:Male; D008875:Middle Aged; D011339:Probenecid / Q000494:pharmacology; D011618:Psychotic Disorders / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D005680:gamma-Aminobutyric Acid / Q000134:cerebrospinal fluid*
D005680:gamma-Aminobutyric Acid; D006220:Haloperidol; D011339:Probenecid; D006719:Homovanillic Acid