[Characteristics of the course of alloxan diabetes in rats with various methods of isografting the islands of Langerhans].
The course of alloxan diabetes in rats in different methods of isotransplantation of the islets of Langerhans isolated by means of trypsin, versen, and collagenase was studied. The transplanted islets can compensate insulin deficiency in rats with experimental diabetes. The period of normoglycemia depended on the number of the transplanted islets and the sites of their introduction. In intraperitoneal and intramuscular (m. rectus abdominis) methods of the islet tissue implantation normoglycemia was observed from 1.5 to 3.5 months, and in intrahepatic method it persisted from 4 to 10 months. The advantage of intrahepatic transplantation of the islets of Langerhans was shown.
D000818:Animals; D000831:Animals, Newborn; D001786:Blood Glucose / Q000032:analysis; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology / Q000601:surgery*; D016381:Islets of Langerhans Transplantation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014185:Transplantation, Isogeneic
D001786:Blood Glucose
Osobennosti techeniia alloksanovogo diabeta u krys pri razlichnykh sposobakh izotransplantatsii ostrovkov Langergansa.