Immunologic implications of insulin delivery and the role of immune complexes in diabetic sequelae.
Insulin has been studied as a model antigen in relation to the functions of immune sensing, modulating, and effector responses to antigens. Each of these immune responses has been associated to the major histocompatibility complex in animals and man. This report summarizes key features of established involvement of antigens in the immune response to various insulin preparations.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis / Q000502:physiology*; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000276:immunology*; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007330:Insulin Antibodies / Q000276:immunology*; D008213:Lymphocyte Activation; D051379:Mice; D013601:T-Lymphocytes / Q000187:drug effects
D000936:Antigen-Antibody Complex; D006680:HLA Antigens; D007328:Insulin; D007330:Insulin Antibodies