[Increased efficacy of allogenic bone marrow transplantation].
Experiments made in vivo and vitro have demonstrated that conservation of allogeneic hemopoietic tissue with glycerin brings about a decrease in transplatation, homologous activity of T lymphocytes. Allogeneic bone marrow conserved with glycerin compares very favourably with freshly prepared allogeneic bone marrow since the transplant-versus-host reaction is attenuated under the effect of glycerin. Moreover, it shows a higher proliferative activity. The glycerin-induced reduction of the inactivating effect of lymphocytes against non-syngeneic colony-forming units enables the conserved bone marrow to be transplanted from several donors.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000276:immunology; D016026:Bone Marrow Transplantation; D003114:Colony-Forming Units Assay; D005990:Glycerol / Q000276:immunology; D006087:Graft vs Host Reaction / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D014021:Tissue Preservation; D014181:Transplantation Immunology / Q000187:drug effects; D014184:Transplantation, Homologous
D005990:Glycerol
Povyshenie éffektivnosti transplantatsii allogennogo kostnogo mozga.