[Localization of apoprotein B in human dermis. A study using optical and electronic immunoprocedures].
The structural localization of apo B, the major protidic constitute of low density plasma lipoproteins, was investigated in human dermis using an immunofluorescence procedure and an immunoperoxidase technique. Apo B was found attached to plasmic fibroblast membranes and along collagen fibers. Dermal areas containing apo B were more numerous in patients with coronary disease than in subjects of the same age with healthy coronary vessels. These results are consistent with those of biochemical determinations: concentrations of apo B in the aorta and skin are parallel and vary according to the severity of atheromatous lesions.
D001053:Apolipoproteins / Q000032:analysis*; D001055:Apolipoproteins B; D002462:Cell Membrane / Q000032:analysis; D003327:Coronary Disease / Q000473:pathology; D005347:Fibroblasts / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008854:Microscopy, Electron; D008875:Middle Aged; D012867:Skin / Q000032:analysis* / Q000648:ultrastructure
D001053:Apolipoproteins; D001055:Apolipoproteins B
Localisation de l'apoprotéine B dans le derme humain. Etude par immunomarquages optique et électronique.