Effects of high dose antacids on bowel motility.
The effect of two antacid preparations containing magnesium and aluminum (Riopan, Maaloxan) on stool frequency, stool consistency, stool weight and oro-anal transit time was tested in a randomized, controlled, double-blind study in 10 healthy volunteers. Both antacids increased stool weight and stool frequency, and lowered stool consistency. The oro-anal transit time was not affected. Antacid-induced diarrhea apparently depends more on changes of transmural fluid transport than on changes of intestinal motility. Thus, secretory and osmotic diarrhea can occur without accompanying changes in gastrointestinal motility.
D000328:Adult; D000536:Aluminum Hydroxide / Q000633:toxicity; D000863:Antacids / Q000008:administration & dosage / Q000633:toxicity*; D002986:Clinical Trials as Topic; D003967:Diarrhea / Q000139:chemically induced; D004311:Double-Blind Method; D005243:Feces / Q000032:analysis; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D007421:Intestine, Small / Q000187:drug effects; D008278:Magnesium Sulfate / Q000633:toxicity; D008297:Male; D009997:Osmotic Pressure; D011897:Random Allocation; D013997:Time Factors
D000863:Antacids; D000536:Aluminum Hydroxide; D008278:Magnesium Sulfate