Significance of chromosome abnormalities in leukemia.
The review deals with technical considerations in relation to culturing and studying the chromosomes of leukemic cells. Specific and non-random chromosomal changes are described by the historic approach. Then follows a description of the application of chromosomal studies to diagnosis, progress and followup in the chronic and acute leukemias. A section is devoted to the application of chromosomal studies in bone-marrow transplantation. Finally, lines of research for leukemia using a genetic approach are suggested.
D016026:Bone Marrow Transplantation; D002869:Chromosome Aberrations / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D002871:Chromosome Banding / Q000379:methods; D025063:Chromosome Disorders; D002904:Chromosomes, Human, 21-22 and Y; D002906:Chromosomes, Human, 6-12 and X; D005500:Follow-Up Studies; D006801:Humans; D007621:Karyotyping; D007938:Leukemia / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D008677:Metaphase; D009196:Myeloproliferative Disorders / Q000235:genetics; D011379:Prognosis; D013997:Time Factors; D014178:Translocation, Genetic; D014314:Trisomy