Mechanisms of beat-to-beat variability in the heart rate of the neonatal lamb. II. Effects of hypoxia.
The effects of acute hypoxia on the resting arterial pressure as well as on heart rate and its beat-to-beat variability were studied in chronically instrumented, unanesthetized newborn lambs at 2 to 8 weeks of neonatal life. Lung ventilation with a gas mixture containing 10% oxygen and 3% carbon dioxide decreased arterial blood PO2 by about 50% in all animals regardless of age without significantly altering blood pH and PCO2. This degree of hypoxia produced a mild pressor response, accompanied by a significant tachycardia; the pattern of these changes, however, differed somewhat according to neonatal growth. The impact of hypoxia on beat-to-beat variability of the neonatal heart rate also varied with age. When the lambs were 2 to 3 weeks old, both the long- and short-term variabilities decreased progressively during hypoxia and the decrement reached a maximum at 10 minutes of oxygen deprivation. As the lambs became older, however, there was some initial and transient increase in the long- and short-term variabilities in the early period of hypoxia but thereafter the changes were inconsistent. The significance of these observations is discussed in terms of our knowledge of the pathophysiologic alterations in the cardiovascular system produced by acute hypoxia.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D002319:Cardiovascular System / Q000503:physiopathology; D006339:Heart Rate; D000860:Hypoxia / Q000503:physiopathology / Q000662:veterinary*; D010100:Oxygen / Q000097:blood; D012756:Sheep / Q000254:growth & development / Q000502:physiology*
D002245:Carbon Dioxide; D010100:Oxygen