Chelation in metal intoxication. VIII. Removal of chromium from organs of potassium chromate administered rats.
Some polyaminocarboxylic acids were examined for their ability to mobilize chromium from certain vital organs, their subcellular fractions, and blood cells of potassium chromate administered rats. Hexamethylene 1,6-diamino tetraacetic acid (TDTA), triethylene tetramine hexaacetic acid (TTHA), and ethylene diamine di (O-hydroxylphenyl acetic acid) (EDDHA) may be useful in preventing or reducing chromate toxicity. No definite relationship could be observed between the structure of the chelating agents and their chromium-removing capacity.
D000818:Animals; D001921:Brain / Q000378:metabolism; D002614:Chelating Agents / Q000494:pharmacology*; D002840:Chromates / Q000506:poisoning*; D002857:Chromium / Q000097:blood / Q000378:metabolism*; D004492:Edetic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D004533:Egtazic Acid / Q000494:pharmacology; D005029:Ethylenediamines / Q000494:pharmacology; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008660:Metabolism; D009206:Myocardium / Q000378:metabolism; D011192:Potassium Dichromate / Q000506:poisoning*; D051381:Rats
D002614:Chelating Agents; D002840:Chromates; D005029:Ethylenediamines; D002857:Chromium; C011813:ethylenediamine-N,N'-bis(2-hydroxyphenylacetic acid); C026061:HDTA; D004533:Egtazic Acid; C026058:EDDA; C026059:triethylenetetraminehexaacetic acid; D004492:Edetic Acid; C026060:N-(hydroxyethyl)ethylenediaminetriacetic acid; D011192:Potassium Dichromate