Platelet production time, uricemia, and some hemostasis tests in pre-eclampsia.
In order to choose the best adapted test for pre-eclampsia monitoring, platelet production time (PPT) was measured simultaneously with uricemia, factor VIII complex, beta-thrombogobulin, and other tests of platelet activation including platelet volume, density and platelet very dense body content. In the pre-eclamptic group (11 patients). In the PPT was significantly reduced in comparison with normal pregnancies (6 patients). In the pre-eclamptic group, there was good and significant correlation between PPT and the VIIIrAg/VIIIc ration (r = 0.87) and between PPT and uricemia (r = 0.79). The correlations between PPT and the other tests are poor and non-significant. Thus, for clinical purposes, the VIIIrAg/VIIIc ratio and uricemia are convenient parameters, and give very reliable information on the severity of the consumption coagulopathy which characterizes pre-eclamptic pregnancies.
D000328:Adult; D000941:Antigens; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D001792:Blood Platelets / Q000502:physiology; D005169:Factor VIII; D005260:Female; D006487:Hemostasis; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010976:Platelet Count; D011225:Pre-Eclampsia / Q000097:blood* / Q000276:immunology; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D013997:Time Factors; D014527:Uric Acid / Q000097:blood*
D000941:Antigens; D014527:Uric Acid; D005169:Factor VIII