[Assessment of biological and hormonal diagnostic criteria in acromegaly (author's transl)].
A review of 30 cases of acromegaly has confirmed the limited diagnostic interest of serum phosphorus determination as it was elevated in 40% of cases only; urine hydroxyproline excretion was more useful, since it was high in 80% cases. As for the baseline plasma concentration of somatotropin, it was at or above 10 ng/ml in 80% cases. Among dynamic tests meant to evaluate the responsiveness of the growth hormone-secreting adenoma, inhibition after L-Dopa ingestion and/or stimulation after T.R.H. injection occurred in 2/3 cases. Lack of inhinition after a glucose load was noted in half of the cases only. An abnormal (yet typical for acromegaly) response can be obtained for anyone of these tests, which points at the variable degree of (de) differenciation of the adenoma cells from one case to the other.
D000172:Acromegaly / Q000097:blood* / Q000175:diagnosis; D005260:Female; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007980:Levodopa; D008297:Male; D013973:Thyrotropin-Releasing Hormone
D007980:Levodopa; D013973:Thyrotropin-Releasing Hormone; D013006:Growth Hormone
Validité des données biologiques, hormonales ou autres, pour le diagnostic de l'acromégalie.