[Indices for assessing genetic damage induced by chemical compounds. Assessment of the induction of sister chromatid exchange by chemical compounds].
Some preferences of using the new index "number of chromosomes involved in the exchange" in comparison with the standard index "number of SCE per cell" are discussed. The mean probability of the induced involving a chromosome into the exchange is estimated as (formula: see book) where pt and pc are the mean number of chromosomes involved in the exchange divided to the total number of chromosomes in the test and control groups, respectively.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001388:Aziridines / Q000494:pharmacology; D003434:Crossing Over, Genetic / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005821:Genetic Techniques; D009153:Mutagens / Q000494:pharmacology*; D011687:Purines; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D000970:Antineoplastic Agents; D001388:Aziridines; D009153:Mutagens; D011687:Purines; C007779:fotrin; C015893:pumitepa
Pokazateli otsenki geneticheskikh povrezhdeniĭ, indutsirovannykh khimicheskimi soedineniiami. Otsenka induktsii khimicheskimi soedineniiami sestrinskikh khromatidnykh obmenov.