Clinical biochemical aspects of glutaminase toxicity in rabbits and Rhesus monkeys.
Treatment with a chemically modified glutaminase was lethal to rabbits and Rhesus monkeys at all but the lowest doses. Changes in the serum levels of triglycerides, glucose, creatinine, urea, cholesterol and protein and in the activities of some serum enzymes were the probable result of the development of lesions in liver, kidney and intestine observed at necropsy. Treatment with unmodified glutaminase induced similar changes in rabbits but not in Rhesus monkeys.
D000596:Amino Acids / Q000097:blood; D000818:Animals; D001772:Blood Cell Count; D004798:Enzymes / Q000097:blood; D005260:Female; D005972:Glutaminase / Q000097:blood / Q000633:toxicity*; D000882:Haplorhini; D008253:Macaca mulatta; D008297:Male; D008670:Metals / Q000097:blood; D011817:Rabbits; D013997:Time Factors
D000596:Amino Acids; D004798:Enzymes; D008670:Metals; D005972:Glutaminase