[Recirculation in the acute period of cerebral infarction: experimental research--brain swelling and its suppression using mannitol and glycerol (author's transl)].
Using our previously published "incomplete cerebral hemispheric infarction model in dogs" (produced by simultaneous, ipsilateral occlusion of the anterior cerebral artery at the branching of the ethmoidal artery from its A1 portion, the A2 portion, the internal carotid artery, the posterior communicating artery, the posterior cerebral artery and the anterior cerebellar artery), 2-, 4-, and 6-hour occlusion of blood flow were undertaken. Observations were then made on the degree of suppression of brain swelling following recirculation due to administration of various mannitol and glycerol solutions. Furthermore, the leakage of Evans Blue was investigated to determine the damage of blood brain barrier. 1. In the animals administered mannitol and glycerol, brain swelling was suppressed following 2-hour occlusion. In the animals administered only mannitol, however, brain swelling was not suppressed after 4- or 6-hour occlusion. 2. After 2-hour occlusion in the animals administered mannitol, leakage of Evans Blue was slight compared with control group. In the 6-hour occlusion animals, severe leakage of Evans Blue was seen. After 2-hour occlusion in the animals administered glycerol, in 1 out of 5, 1 g/kg administered group and 2 out of 5, 2 g/kg administered group, severe leakage of Evans Blue was seen even when there was little brain swelling.
D000818:Animals; D001929:Brain Edema / Q000517:prevention & control*; D002544:Cerebral Infarction / Q000209:etiology / Q000473:pathology*; D002560:Cerebrovascular Circulation; D004285:Dogs; D005990:Glycerol / Q000494:pharmacology*; D008353:Mannitol / Q000494:pharmacology*
D008353:Mannitol; D005990:Glycerol