Pulmonary extraction of biogenic amines during septic shock.
The effect of live Escherichia coli on the pulmonary extraction of the biogenic amines 14C 5-hydroxytryptamine, (5-HT) and 3H-epinephrine was investigated. The labeled isotopes were injected into a central venous catheter and collected from an aortic catheter. One hundred per cent of the labeled epinephrine was recovered in the control and septic state. Only 32.8 +/- 3.6% SEM of the 5-hydroxytryptamine was recovered before sepsis and 42.5 +/- 4.9% SEM after sepsis. During sepsis, mean arterial pressure fell to 58 mm Hg from 121 mm Hg. Pulmonary shunt increased from .7 +/- .05 SEM to .33 +/- .09 SEM.
D000818:Animals; D001794:Blood Pressure; D002250:Carbon Radioisotopes; D004837:Epinephrine / Q000378:metabolism* / Q000502:physiology; D004926:Escherichia coli / Q000502:physiology; D004927:Escherichia coli Infections / Q000503:physiopathology; D008168:Lung / Q000378:metabolism* / Q000503:physiopathology; D008297:Male; D008657:Metabolic Clearance Rate; D012701:Serotonin / Q000378:metabolism* / Q000502:physiology; D012772:Shock, Septic / Q000378:metabolism* / Q000503:physiopathology; D014316:Tritium
D002250:Carbon Radioisotopes; D014316:Tritium; D012701:Serotonin; D004837:Epinephrine