Interaction of arachidonic acid and heme iron in the synthesis of prostaglandins.
The reaction of ferrous iron and oxygen to oxidize arachidonic acid has been studied to aid in understanding the mechanism of PGG2 formation. Based on these results we have presented a novel concept of heme-arachidonic acid interaction in PG synthesis.
D000818:Animals; D001095:Arachidonic Acids; D001665:Binding Sites; D001792:Blood Platelets / Q000378:metabolism; D006418:Heme; D007213:Indomethacin; D007501:Iron; D008968:Molecular Conformation; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis*
D001095:Arachidonic Acids; D011453:Prostaglandins; D006418:Heme; D007501:Iron; D011451:Prostaglandin-Endoperoxide Synthases; D007213:Indomethacin