Studies of mutagenicity on quiescent and proliferating hamster cell populations.
A few known mutagens were tested on proliferating hamster cells and on cells made quiescent by L-histidinol block. No differences were found in the effectiveness of two alkylating agents and a base analogue; whereas the carcinogen 4-nitroquinoline-1-oxide was more effective on quiescent than on proliferating cells. The implications of these data on the mechanism of action of mutagens are discussed.
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D006224:Cricetinae; D005020:Ethyl Methanesulfonate / Q000494:pharmacology; D006641:Histidinol / Q000494:pharmacology; D007399:Interphase / Q000187:drug effects; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D009153:Mutagens; D013997:Time Factors
D009153:Mutagens; D008769:Methylnitronitrosoguanidine; D006641:Histidinol; D015112:4-Nitroquinoline-1-oxide; D005020:Ethyl Methanesulfonate; D001973:Bromodeoxyuridine