A report on the safety of an intravenous compound calcium solution and the levels of plasma total and ionized calcium following injection.
An intravenous compound 5% calcium solution was subjected to three trials in S.A. Mutton Merino X Merino ewes to establish its safety and also to resultant levels of blood total and particularly ionized calcium. In the first trial, 10 animals each received 20 ml of the compound but the administration time progressively decreased from 90 seconds in the first to only 15 seconds in the last ewe. Plasma total calcium levels more than doubled in all the animals and, except for transient disorientation in the last ewe, nothing untoward was noted. In the second trial 4 ewes again received 20 ml of the compound while in the third trial 5 ewes received the compound at the rate of 0,5 ml/kg. In both trials the administration time was about 30 seconds. Plasma total and ionized calcium levels more than doubled initially and, while there was a steady and parallel decline in both, they were still more than 60% higher than pre-injection levels after as long as 2 hours.
D000818:Animals; D002118:Calcium / Q000008:administration & dosage* / Q000097:blood*; D002986:Clinical Trials as Topic; D005260:Female; D007263:Infusions, Parenteral; D008274:Magnesium / Q000097:blood; D012756:Sheep; D013997:Time Factors
D008274:Magnesium; D002118:Calcium