Bile acids inhibit pepsin activity against a refined substrate.
Studies using a refined substrate, n-acetyl-L-phenylalanyl-L-diiodotyrosine [n-APDT], demonstrate that bile salts inhibit pepsin activity in vitro by a noncompetitive effect on the enzyme.
D001647:Bile Acids and Salts / Q000494:pharmacology*; D004151:Dipeptides; D005999:Glycochenodeoxycholic Acid / Q000494:pharmacology; D006000:Glycocholic Acid / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D010434:Pepsin A / Q000037:antagonists & inhibitors*; D013379:Substrate Specificity; D013655:Taurochenodeoxycholic Acid / Q000494:pharmacology; D013656:Taurocholic Acid / Q000494:pharmacology
D001647:Bile Acids and Salts; D004151:Dipeptides; D013655:Taurochenodeoxycholic Acid; D013656:Taurocholic Acid; D005999:Glycochenodeoxycholic Acid; D010434:Pepsin A; D006000:Glycocholic Acid