Glucose promotes intracellular sequestration of manganese in pancreatic beta-cells.
D-glucose reduces the outflow of manganese from pancreatic beta-cells in analogy to what has previously been reported for 45Ca. The decrease can be accounted for by an enhanced intracellular sequestration. The effect of D-glucose on manganese fluxes seems to be restricted to inhibition of the efflux; no stimulation of the influx being noted. The glucose-dependence of manganese uptake is hyperbolic with half maximal stimulation between 5 and 6 mM D-glucose.
D002118:Calcium / Q000378:metabolism; D005947:Glucose / Q000494:pharmacology*; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D008345:Manganese / Q000378:metabolism*
D008345:Manganese; D005947:Glucose; D002118:Calcium