The action of sodium cromoglycate on 'C' fibre endings in the dog lung.
The effect has been studied of sodium cromoglycate (SCG) on the activity of 'C' fibre sensory nerve endings in the canine lung. Pretreatment with SCG (100 microgram/kg i.v.) reduced the excitation of these endings by capsaicin (10 microgram/kg i.v.) for approximately 45 min. This property of SCG may explain its ability to suppress certain types of bronchoconstrictor responses in man.
D000403:Airway Resistance / Q000187:drug effects; D000758:Anesthesia; D000818:Animals; D002211:Capsaicin / Q000494:pharmacology; D004205:Cromolyn Sodium / Q000494:pharmacology*; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects; D008168:Lung / Q000294:innervation*; D008170:Lung Compliance / Q000187:drug effects; D009411:Nerve Endings / Q000187:drug effects*
D004205:Cromolyn Sodium; D002211:Capsaicin