[Effect of Brucella abortus on growth of ovarian granulosa cell carcinoma].
Live brucellosis vaccine Brucella abortus administered intraperitoneally, intravenously, subcutaneously or into the tumorous node inhibits the growth of granular cell ovarian carcinoma OC-1-72. The inhibitory effect depends on the B. abortus dose and tumor size. Pretreatment with B. abortus led, in some experiments, to the stimulation of tumor growth. The similar action was demonstrated by killed B. abortus vaccine administered into the tumorous node. The inhibitory effect on tumor growth can be mediated through the peritoneal exudate cells and spleen cells. Serum and an extract from spleens of mice infected with B. abortus inhibit the development of Rauscher's viral leukemia.
D000818:Animals; D002004:Brucella Vaccine / Q000008:administration & dosage / Q000627:therapeutic use*; D002003:Brucella abortus; D005260:Female; D006106:Granulosa Cell Tumor / Q000628:therapy*; D007116:Immunization, Passive; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D007942:Leukemia, Experimental / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D010051:Ovarian Neoplasms / Q000628:therapy*; D011925:Rauscher Virus; D013997:Time Factors
D002004:Brucella Vaccine
Vliianie Brucella abortus na rost granulezokletochnoĭ kartsinomy iaichnika.