[Effects of diacetoxyscirpenol on experimental candidiasis of mice].
A single injection of 4.5 mg/kg of diacetoxyscirpenol (a toxin synthesized by Fusarium) into Mice challenged by C. albicans, increases significantly the development of an experimental candidiasis. Suspensions of homogenized kidneys was spread on Sabouraud dextrose agar plates and the colonies of C. albicans were counted after 24 hrs incubation. The mean values were determined. Comparison of mean values calculated for kidneys from the Mice challenged with C. albicans and those challenged with C. albicans plus toxin gave highly significant results.
D000818:Animals; D002177:Candidiasis / Q000209:etiology* / Q000276:immunology; D007166:Immunosuppressive Agents; D007668:Kidney / Q000382:microbiology; D008297:Male; D051379:Mice; D012717:Sesquiterpenes / Q000494:pharmacology*; D014255:Trichothecenes / Q000494:pharmacology*
D007166:Immunosuppressive Agents; D012717:Sesquiterpenes; D014255:Trichothecenes; C001809:diacetoxyscirpenol
Action du diacetoxyscirpénol sur la candidose expérimentale de la Souris.