[State of circulation and the body's oxygen supply following total blood replacement with perfluorotributylamine emulsion].
A possibility of oxygen transfer by perftorbutylamine emulsion was shown in preliminary experiments on an isolated rabbit heart. 12% perftorbutylamine emulsion was obtained with the aid of the Soviet emulsifier-7% copolymerr of hydroxyethylene and hydroxypropylene. It was supplemented with electrolytes and rheopolyglucin solution at a ratio of 1:4. The parameters of hemodynamics and oxygen body supply were studied in cat experiments involving complete blood replacement by the emulsion (Hct 3%). The life-span of the animals was 3-5 hours. The death was chiefly caused by distrubed circulation consequent on hypovolemia. The fact of excluding red cells that remained in the blood flow bed from the active gas exchange was also ascertained and attributed to PO2 increase in mixed venous blood up to 160mm Hg.
D000818:Animals; D001794:Blood Pressure; D001810:Blood Volume; D002082:Butylamines; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output; D002415:Cats; D002496:Central Venous Pressure; D004655:Emulsions; D005466:Fluorocarbons; D006400:Hematocrit; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D010108:Oxyhemoglobins; D010952:Plasma Substitutes
D002082:Butylamines; D004655:Emulsions; D005466:Fluorocarbons; D010108:Oxyhemoglobins; D010952:Plasma Substitutes; D002245:Carbon Dioxide; C008807:perfluorotributylamine; D010100:Oxygen
Sostoianie krovoobrashcheniia i kislorodnogo snabzheniia organizma pri polnoĭ zamene krovi émul'sieĭ perftortributilamina.