Surface immunoglobulins in human chronic leukemia cells.
By means of the cytotoxic and immunofluorescence tests, frequency of various classes of immunoglobulins (IgG, IgA, IgM, IgD, IgE) and light chains was examined in peripheral pathologic blood cells of patients with chronic granulocytic and lymphatic leukemia. The dominant immunoglobulins were of the IgD and IgE classes. Light chains of both types were present in cells of chronic granulocytic leukemia, and kappa type in chronic lymphatic leukemia. Use of the method of resynthesis of digested immunoglobulins in vitro confirmed the monoclonal origin of chronic lymphatic leukemia in humans.
D006098:Granulocytes / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000302:isolation & purification; D007072:Immunoglobulin D / Q000302:isolation & purification; D007073:Immunoglobulin E / Q000302:isolation & purification; D007074:Immunoglobulin G / Q000302:isolation & purification; D007147:Immunoglobulin Light Chains / Q000302:isolation & purification; D007075:Immunoglobulin M / Q000302:isolation & purification; D066298:In Vitro Techniques; D007945:Leukemia, Lymphoid / Q000276:immunology*; D007951:Leukemia, Myeloid / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000302:isolation & purification*
D007070:Immunoglobulin A; D007072:Immunoglobulin D; D007074:Immunoglobulin G; D007147:Immunoglobulin Light Chains; D007075:Immunoglobulin M; D011947:Receptors, Antigen, B-Cell; D007073:Immunoglobulin E