Induction of rat hepatic UDP-glucuronosyltransferases by dietary ethoxyquin.
Dietary administration of 0.5% ethoxyquin markedly enhanced rat hepatic UDP-glucuronosyltransferase activities. Both 3-methylcholanthrene- and phenobarbital-inducible glucuronidation reactions were stimulated by the antioxidant. In contrast, phenobarbital-inducible bilirubin glucuronidation was not affected by ethoxyquin.
D000818:Animals; D001663:Bilirubin / Q000378:metabolism; D004032:Diet; D004790:Enzyme Induction / Q000187:drug effects; D005015:Ethoxyquin / Q000494:pharmacology*; D014453:Glucuronosyltransferase / Q000096:biosynthesis*; D008099:Liver / Q000201:enzymology*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D010634:Phenobarbital / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats
D011804:Quinolines; D008748:Methylcholanthrene; D005015:Ethoxyquin; D014453:Glucuronosyltransferase; D001663:Bilirubin; D010634:Phenobarbital