Judging models in QSAR- and LFE-like studies if there are no replications: correlation of dipeptidyl peptidase IV hydrolytic activities of L-Alanyl-L-alanine phenylamides.
Provided that the assumptions of regression analysis type I are met, an independent estimate of the standard deviation of the regressand using the method of near neighbors may be computed. The comparison of this estimate with the residual standard deviation obtained from a equation will reveal if there is some probability to get better equations not superimposed by chance correlation. A structure-activity relationship concerning the dependence of log Vmax for the hydrolytic cleavage of the substrates L-ala-L-ala-Y on physicochemical substituent constants demonstrates the usefulness of this procedure.
D002384:Catalysis; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D004151:Dipeptides / Q000378:metabolism; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases / Q000378:metabolism*; D010450:Endopeptidases / Q000378:metabolism*; D006868:Hydrolysis; D008954:Models, Biological; D013329:Structure-Activity Relationship
D004151:Dipeptides; C002956:alanylalanine; D010450:Endopeptidases; D004152:Dipeptidyl-Peptidases and Tripeptidyl-Peptidases