Red blood cells amino-acid pattern in protein energy malnutrition and the effect of oral dosing with single amino acids.
R.B.C.'s amino acid pattern was investigated in control and PEM subjects. The effect of oral dosing with cysteine, tryptophan and lysine on total amino acid nitrogen level of R.B.C.s was also studied. Results revealed that in moderate and severe kwashiorkor the total essential and non-essential R.B.C.'s amino acids were decreased. In 2nd grade marasmus the total R.B.C.'s amino acids in general showed lower values than normal. After oral administration of the tested amino acids, the transport index calculated as the level of maximum value of the total R.B.C.'s amino acids reached to the fasting level was lower in malnourished cases relative to controls except in 2nd grade marasmic cases given tryptophan or lysine. This criteria was considered to indicate lower rate of amino acid transport to R.B.C.s due to lower concentration in plasma or shift of transport mechanism from active transport to exchange diffusion.
D000596:Amino Acids / Q000097:blood*; D000601:Amino Acids, Essential / Q000097:blood; D001692:Biological Transport; D002675:Child, Preschool; D003545:Cysteine / Q000494:pharmacology*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007732:Kwashiorkor / Q000097:blood; D008239:Lysine / Q000494:pharmacology*; D011502:Protein-Energy Malnutrition / Q000097:blood* / Q000145:classification; D014364:Tryptophan / Q000494:pharmacology*
D000596:Amino Acids; D000601:Amino Acids, Essential; D014364:Tryptophan; D008239:Lysine; D003545:Cysteine