[Aldose-reductase inhibitors and cataract formation (author's transl)].
Flavonoids are known as potent inhibitors of aldose reductase, an enzyme that may initiate cataract formation in diabetes. We have tested the inhibitory activity of new flavone derivatives on a homogenate of lens epithelium. Compounds which inhibited the enzyme activity by more than 50 percent at 10(-60) M were then tested on rat lenses perfused in a 0.027 M glucose solution. Our preliminary studies indicate that these new flavone derivatives can prevent or delay the formation of cataract in an in-vitro model.
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002386:Cataract / Q000209:etiology / Q000517:prevention & control*; D048909:Diabetes Complications; D005419:Flavonoids / Q000494:pharmacology*; D007908:Lens, Crystalline / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*
D005419:Flavonoids; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase
Inhibiteurs d'aldose-réductase et cataracte.