Recurrent Salmonella meningitis in a compromised host.
A 26-year-old woman with Hodgkin's disease had recurrent episodes of meningitis caused by Salmonella enteritidis serotype poona, which responded well to antimicrobial therapy. An extensive investigation failed to reveal a focus of infection. A defective cellular immune response and the intracellular location of these microorganisms probably accounted for the pattern of infection seen in this patient. The need for long-term therapy in compromised patients with this type of infection is stressed.
D000328:Adult; D001853:Bone Marrow / Q000276:immunology; D002701:Chloramphenicol / Q000627:therapeutic use; D005260:Female; D006689:Hodgkin Disease / Q000150:complications* / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D008581:Meningitis / Q000150:complications* / Q000188:drug therapy; D012008:Recurrence; D012480:Salmonella Infections / Q000150:complications* / Q000188:drug therapy; D012477:Salmonella enteritidis; D013997:Time Factors
D002701:Chloramphenicol