Interference between anti-HLA antibodies and CPZ metabolites.
The interference of chlorpromazine (CPZ) and several preincubated CPZ metabolites on the lymphocyte absorption of antibodies directed against HLA-A1 and other nonrelated HLA specificities were investigated. Both CPZ and metabolites 7-OH-, Nor1-, and Nor2-CPZ were found to interfere with the specific absorption of anti-HLA-A1 antibodies. The meaning of such a result is discussed.
D000042:Absorption; D000906:Antibodies; D002746:Chlorpromazine / Q000378:metabolism*; D003429:Cross Reactions; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism
D000906:Antibodies; D006680:HLA Antigens; D002746:Chlorpromazine