Endocrine mechanisms in the pathogenesis of essential hypertension. II. Interference of prostaglandins with the blood pressure elevating and lowering systems.
Beside exerting an impressive variety of physiological and pharmacological actions on different systems of the organism, prostaglandins (PGs) may also be main factors in the pathogenesis of essential hypertension. Their role in this process is mostly explained by their multivalent interference with the tissue hormones which regulate the vascular tone and the water-sodium balance. In this paper a discussion regarding the results of a widespread research and the growing literature dealing with this interference is made on the basis of a personal point of view. The present paper is a continuation of a previous one on this topic.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000209:etiology*; D011453:Prostaglandins / Q000096:biosynthesis / Q000172:deficiency*; D011455:Prostaglandins A, Synthetic / Q000494:pharmacology; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology; D011465:Prostaglandins, Synthetic / Q000494:pharmacology; D014882:Water-Electrolyte Balance / Q000187:drug effects
D011453:Prostaglandins; D011455:Prostaglandins A, Synthetic; D011459:Prostaglandins E, Synthetic; D011465:Prostaglandins, Synthetic