Prophylactive treatment with flunisolide after polypectomy.
Twenty-two patients with nasal polyps completed a double-blind study with a new topical corticosteroid, flunisolide. Treatment during three months after operation gave, in comparison with placebo, a statistically significant effect on the symptom of stuffy nose, and on the sum of scores for stuffy nose, runny nose and sneezing. There was no significant effect on rhinomanometry. Side effects were negligible. Three patients in the placebo-group required a further operation within one year but none in the flunisolide group. Prophylactic treatment with flunisolide can be recommended as a complement to other treatment after surgery of nasal polyps.
D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005446:Fluocinolone Acetonide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000175:diagnosis / Q000517:prevention & control* / Q000601:surgery; D009364:Neoplasm Recurrence, Local
D000893:Anti-Inflammatory Agents; D005446:Fluocinolone Acetonide; C007734:flunisolide