Ultrastructural morphology of granule release from juxtaglomerular myoepithelioid and peripolar cells.
The morphology of granule release from juxtaglomerular myoepithelioid and peripolar cells has been examined. Renin release occurs from myoepithelioid granules by an unusual form of exocytosis via deep channel-like invaginations of the plasma membrane. Such release occurs towards the juxtaglomerular interstitium as well as towards the arteriolar lumen. Peripolar cell granule exocytosis occurs directly into the urinary space in sodium-depleted sheep, tentatively supporting the speculation that it may be the source of an intrarenal sodium-retaining hormone.
D000818:Animals; D003594:Cytoplasmic Granules / Q000648:ultrastructure*; D004285:Dogs; D007606:Juxtaglomerular Apparatus / Q000201:enzymology / Q000648:ultrastructure*; D051379:Mice; D051381:Rats; D012083:Renin / Q000378:metabolism
D012083:Renin