IGA in human bile and liver.
Hepatic bile IgA from 6 patients was measured by radioimmunoassay and characterized immunochemically. The concentration of IgA was 0.14 to 0.88 mg/ml. IgA associated with secretory component (SC) as well as unassociated with SC was demonstrated in all 6 samples; The proportion associated with SC (secretory IgA) was 72% to 95%. IgA and SC were localized immunocytochemically in liver and bile duct tissues by the peroxidase-labeled antibody method. Evidence favoring endocytic, SC-mediated transfer of IgA by intrahepatic and extrahepatic biliary epithelium, but not by hepatocytes, was found.
D001646:Bile / Q000276:immunology*; D001653:Bile Ducts, Intrahepatic / Q000276:immunology; D004848:Epithelium / Q000276:immunology; D006651:Histocytochemistry; D006801:Humans; D005779:Immunodiffusion; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008099:Liver / Q000276:immunology* / Q000648:ultrastructure; D012635:Secretory Component
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012635:Secretory Component