Adaptation to hyperosmolality in the rat.
Hyperosmolality induced in rats results in a progressive increase in brain glutamine levels with out a change in ammonia. This suggests an adaptation in the compartmental nature of the glutamate-ammonia-glutamine metabolic system to provide more brain osmoles without excess ammonia. The brain: blood glucose ratio rose suggesting brain energy use rate reductions previously reported may be due to altered glucose transport or phosphorylation.
D000064:Acclimatization; D000137:Acid-Base Imbalance / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001639:Bicarbonates / Q000097:blood; D001769:Blood; D001921:Brain / Q000378:metabolism*; D002245:Carbon Dioxide / Q000097:blood; D005947:Glucose / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008297:Male; D009994:Osmolar Concentration; D051381:Rats
D000596:Amino Acids; D001639:Bicarbonates; D005973:Glutamine; D002245:Carbon Dioxide; D005947:Glucose