Allotypy of rabbit immunoglobulins: a fifth allele at the a locus.
Studies in wild rabbits (Oryctolagus cuniculus) allowed the detection of a fifth allele (a101) at the a locus of rabbit immunoglobulins. The structures responsible for the A101 allotypic specificity have been found on both IgG and IgM. Their location is on the Fab fragment, on the H chain. None of the rabbits possessing A101 allotypic specificity possessed two known allotypic specificities of the a series. Genetic evidence by breeding studies agree with assignment of A101 to the a series and allow to designate this allotypic specificity as a101. a101 has been found in wild rabbits in different areas in France. It has no detectable cross-reactivity with the known allotypes. The genetic polymorphism of immunoglobulins is much larger in the Oryctolagus cuniculus species than the one described in the domestic form of the species.
D000483:Alleles; D000818:Animals; D001666:Binding Sites, Antibody; D002874:Chromosome Mapping; D003429:Cross Reactions; D007106:Immune Sera / Q000494:pharmacology; D007126:Immunoglobulin Allotypes / Q000235:genetics*; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007075:Immunoglobulin M; D007137:Immunoglobulin alpha-Chains / Q000235:genetics*; D011817:Rabbits
D007106:Immune Sera; D007126:Immunoglobulin Allotypes; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D007075:Immunoglobulin M; D007137:Immunoglobulin alpha-Chains