Gallbladder density and iodine concentration in humans during oral cholecystography. A comparison of iopanoic acid and iopronic acid.
A comparison of two oral cholecystopaques, iopanoic acid (Telepaque) and iopronic acid (Oravue), was performed using normal volunteers. Using a double-blind crossover design, comparisons were made between the degree of gallbladder opacification and the amount of iodine recovered from the gallbladder. Bile was collected via a double lumen intestinal tube before, during, and after stimulating gallbladder contraction. There were no differences between the two agents in terms of opacification or iodine concentration. Only 19% of the administered dose of either agent was recovered, and the maximum iodine concentration in bile was 10 mg I/ml. The results suggest that this technique has merit for future comparative studies of agents concentrated in the gallbladder.
D000284:Administration, Oral; D001647:Bile Acids and Salts / Q000032:analysis; D002765:Cholecystography; D002986:Clinical Trials as Topic; D003287:Contrast Media / Q000008:administration & dosage*; D004311:Double-Blind Method; D005704:Gallbladder / Q000032:analysis; D006801:Humans; D007455:Iodine / Q000032:analysis; D007462:Iodobenzenes / Q000008:administration & dosage*; D007480:Iopanoic Acid / Q000008:administration & dosage*
D001647:Bile Acids and Salts; D003287:Contrast Media; D007462:Iodobenzenes; C006754:iopronic acid; D007455:Iodine; D007480:Iopanoic Acid