Prevention of endomyometritis using antibiotic irrigation during cesarean section.
After double-blind controlled studies demonstrated cefamandole nafate irrigation of the uterus during cesarean section to be effective in reducing the rate of endomyometritis, antibiotic irrigation was adopted as a standard procedure at Tripler Army Medical Center. The present study analyzes the outcome in patients undergoing cesarean section before (comparison group) and after (treatment group) routine use of antibiotic irrigation began. The incidence of endomyometritis in 100 patients from the comparison group was 20% and in 298 patients from the treatment group 1.7% (P less than .0001). Serum analysis for cefamandole nafate demonstrated little systemic absorption of the antibiotic. Cefamandole nafate intrauterine irrigation at cesarean section effectively prevents endomyometritis.
D000328:Adult; D002435:Cefamandole / Q000008:administration & dosage* / Q000031:analogs & derivatives / Q000097:blood; D002511:Cephalosporins / Q000008:administration & dosage*; D002585:Cesarean Section / Q000009:adverse effects*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004716:Endometritis / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D007430:Intraoperative Care; D011247:Pregnancy; D011292:Premedication; D011645:Puerperal Infection / Q000517:prevention & control*; D007507:Therapeutic Irrigation
D002511:Cephalosporins; D002435:Cefamandole; C012810:cefamandole nafate