[Comparative study of fungicidal activity in vitro of various quaternary ammonium compounds used in ophthalmology].
A study was conducted to evaluate the antifungal activity in vitro of 5 quaternary ammonium compounds. N cetylpyridinium was found to be particularly active against Candida albicans and Aspergillus fumigatus. The association of N cetylpyridinium and of neosynephrine, found in various eye drop compositions, resulted in potentation of the antifungal activity of this quaternary ammonium.
D000935:Antifungal Agents; D001232:Aspergillus fumigatus / Q000187:drug effects; D001548:Benzalkonium Compounds / Q000031:analogs & derivatives / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects; D000077286:Cetrimonium; D002593:Cetrimonium Compounds / Q000494:pharmacology; D002594:Cetylpyridinium / Q000494:pharmacology; D004357:Drug Synergism; D006801:Humans; D008826:Microbial Sensitivity Tests; D009883:Ophthalmic Solutions; D010656:Phenylephrine / Q000494:pharmacology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*
D000935:Antifungal Agents; D001548:Benzalkonium Compounds; D002593:Cetrimonium Compounds; D009883:Ophthalmic Solutions; D000644:Quaternary Ammonium Compounds; C013871:cethexonium; D010656:Phenylephrine; D002594:Cetylpyridinium; C015163:dimethyldodecylbenzylammonium; D000077286:Cetrimonium
Etude comparée de l'activité antifongique in vitro de quelques ammoniums quaternaires utilisés en ophtalmologie.