Repair of DNA damage after exposure to 4-nitroquinoline-1-oxide in heterokaryons derived from xeroderma pigmentosum cells.
Xeroderma pigmentosum (XP) cells are deficient in the repair of damage induced by ultraviolet irradiation. Excision-repair-deficient XP cell strains have been classified into 7 distinct complementation groups, according to results of studies on cell fusion and UV irradiation. XP cells are not only abnormally sensitive to UV, but also to a variety of chemical carcinogens, including 4-nitro-quinoline-1-oxide (4NQO). Complementation analysis with XP strains from 4 different complementation groups with respect to the repair of 4NQO-induced DNA damage revealed that the classification of the strains into complementation groups with respect to 4NQO-induced repair coincides with the classification based on the repair of UV damage.
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology*; D002459:Cell Fusion; D002460:Cell Line; D002467:Cell Nucleus; D004247:DNA / Q000378:metabolism*; D004260:DNA Repair; D005816:Genetic Complementation Test; D006579:Heterozygote; D006801:Humans; D009153:Mutagens; D009600:Nitroquinolines / Q000494:pharmacology*; D012867:Skin; D014983:Xeroderma Pigmentosum / Q000235:genetics* / Q000473:pathology
D009153:Mutagens; D009600:Nitroquinolines; D015112:4-Nitroquinoline-1-oxide; D004247:DNA