Comparative unsupervised clinical trial on caries inhibition effect of monofluorophosphate and amine fluoride dentifrices after 3 years in Strasbourg, France.
A randomized, double blind clinical trial of the caries inhibition effects of dentifrices containing respectively monofluorophosphate and amine fluoride was performed. A third control group used a toothpaste without fluoride. A total number of 2008 schoolchildren ranging in age from 6 to 8 years and living in Strasbourg (France) participated in this study. After a baseline examination three groups were constructed with the block randomization technic. The caries inhibition effects of the three dental pastes were compared after 3 years of unsupervised use. The monofluorophosphate dentifrice showed a reduction of 7.02% for DMFT, 5.17% for DMFS and 25.26% for the df rate. The reduction of amine fluoride dentifrice caries was respectively 21.62% for DMFT, 20.94% for DMFS and 48.66% for the df rate.
D000588:Amines / Q000008:administration & dosage*; D000605:Amino Alcohols; D002648:Child; D002986:Clinical Trials as Topic; D004245:DMF Index; D003731:Dental Caries / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D005459:Fluorides / Q000008:administration & dosage*; D005602:France; D006801:Humans; D008297:Male; D010710:Phosphates / Q000008:administration & dosage*; D011897:Random Allocation; D014100:Toothpastes
D000588:Amines; D000605:Amino Alcohols; D010710:Phosphates; D014100:Toothpastes; C012980:fluorophosphate; C036238:amine fluoride 297; D005459:Fluorides