Distribution of myosin, actin and actin-binding protein in thrombasthenic platelets.
The quantity of myosin, actin, and actin-binding protein (ABP) in platelets and platelet fractions of 5 patients with Glanzmann's thrombasthenia were compared to those of normal individuals. No significant differences were observed between the average amounts of these contractile proteins in unfractionated platelets or platelet membrane obtained after osmotic shock. However, the amount of myosin was significantly decreased in the KCl extract of thrombasthenic platelets ruptured by freezing and thawing,while its specific ATPase activity was increased.
D000199:Actins / Q000097:blood*; D000293:Adolescent; D000328:Adult; D001791:Blood Platelet Disorders / Q000097:blood*; D001792:Blood Platelets; D001798:Blood Proteins; D002352:Carrier Proteins / Q000097:blood*; D002675:Child, Preschool; D003720:Densitometry; D004492:Edetic Acid; D004591:Electrophoresis, Polyacrylamide Gel; D005260:Female; D006023:Glycoproteins / Q000097:blood; D006801:Humans; D008297:Male; D009218:Myosins / Q000097:blood*; D009994:Osmolar Concentration; D009997:Osmotic Pressure
D000199:Actins; D001798:Blood Proteins; D002352:Carrier Proteins; D006023:Glycoproteins; D004492:Edetic Acid; D009218:Myosins