Radioreceptor-assayable somatomedins during pregnancy and their relationship to fetal growth.
Seven women were studied longitudinally throughout clinically normal pregnancy. At three-week intervals, maternal plasma was collected and fetal growth was assessed by ultrasound measurements. Maternal plasma somatomedin concentration was determined by radioreceptor assay, using human fetal brain plasma membrane as matrix and insulin-like growth factor 1 as ligand. In adults this assay primarily detects insulin-like growth factors 1 and 2. Plasma radioreceptor-assayable somatomedin values increased progressively throughout pregnancy. Maternal plasma somatomedin values related to fetal biparietal diameter and showed a significant correlation to birth weight and length.
D000328:Adult; D001724:Birth Weight; D005260:Female; D005333:Fetus / Q000502:physiology*; D006128:Growth; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000097:blood; D011247:Pregnancy; D011869:Radioligand Assay; D013002:Somatomedins / Q000097:blood*
D007328:Insulin; D013002:Somatomedins