[Allogenic lung transplantations following pretreatment of recipients with donor-specific splenic antigens].
Lung transplantations were carried out in 20 not immunologically selected mongrel dogs which were pretreated with donor specific spleno-antigen mixture. The average survival time was double the size (12.3 days) as in a control group of untreated dogs after allogenic lung transplantation. A number of the receivers got Cyclophosphamid in addition to the spleno-antigen mixture. In this group the average survival time amounted to 17 days. A chronic course of the rejection was not to be achieved with this method. The autopsy showed thoracic infectious complications in nearly all receivers. A great number of central pulmonary vein thromboses in the transplant was discovered in this series in contrast to other lung transplantation series. Circumstances refer to a connection with hyperacute rejection courses. The receivers of this series survived the destruction of the transplant longer on an average as such in other experimental series.
D000818:Animals; D000941:Antigens / Q000008:administration & dosage*; D004285:Dogs; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D016040:Lung Transplantation; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D011184:Postoperative Period; D013154:Spleen / Q000276:immunology*; D014019:Tissue Donors
D000941:Antigens
Allogene Lungentransplantationen nach Vorbehandlung der Rezipienten mit spenderspezifischem Milzantigen.