9-Hydroxyellipticine: inhibitory effect on skin carcinogenesis induced in Swiss mice by 7,12-dimethylbenz[a]anthracene.
9-Hydroxyellipticine (9-hydroxy-5,11-dimethyl-6-H-pyrido[4,3b]carbazole), a potent inhibitor of monooxygenases, strongly inhibits the initiation of skin tumors by 7,12-dimethylbenz[a]anthracene (DMBA) in male NMRI Swiss mice. 9-Hydroxyellipticine has not effect on promotion step.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors*; D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000037:antagonists & inhibitors*; D004611:Ellipticines / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D012878:Skin Neoplasms / Q000139:chemically induced*; D013997:Time Factors
D000470:Alkaloids; D001551:Benz(a)Anthracenes; D004611:Ellipticines; D015127:9,10-Dimethyl-1,2-benzanthracene; C008009:9-hydroxyellipticine