The inhibition of PGI2 synthetase within the arterial wall by 15-hydroperoxyarachidonic acid enhances local white platelet thrombosis.
Prostaglandins play an important role in platelet-vessel wall interaction. The inhibition of PGI2 synthetase by 15-hydroxyarachidonic acid (15-HPAA) results in an enhancement of local thrombus formation.
D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D001158:Arteries / Q000201:enzymology*; D001792:Blood Platelets / Q000187:drug effects*; D016861:Cyclooxygenase Inhibitors; D011464:Epoprostenol / Q000096:biosynthesis*; D066298:In Vitro Techniques; D015289:Leukotrienes; D008054:Lipid Peroxides; D008297:Male; D010545:Peroxides / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D013927:Thrombosis / Q000139:chemically induced*
D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D015289:Leukotrienes; D008054:Lipid Peroxides; D010545:Peroxides; D011453:Prostaglandins; C025086:15-hydroperoxy-5,8,11,13-eicosatetraenoic acid; D011464:Epoprostenol