Anti-timothy IgE formation: suppression with antigen D-dGl conjugates.
Antigen D fragments (AgD1 and AgD2) and chemically synthesized quercetin-glutathione were conjugated to the synthetic polypeptide copolymer of D-glutamic acid and D-lysine (dGL). These conjugates were tested at varying epitope densities to determine their ability to suppress a secondary anti-antigen B IgE response. The data showed that all of the conjugates used with epitope densities of 5-20 groups per dGL produced significant dose-dependent suppression of a secondary IgE response. The duration of the observed suppression was short (about 30 days), but could be extended by additional treatment with the conjugate prior to the loss of unresponsiveness.
D000707:Anaphylaxis / Q000175:diagnosis; D000818:Animals; D000941:Antigens; D005971:Glutamates / Q000276:immunology; D005978:Glutathione / Q000276:immunology; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007165:Immunosuppression Therapy; D008239:Lysine / Q000276:immunology; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis; D011058:Pollen; D011794:Quercetin / Q000276:immunology; D051381:Rats
D000941:Antigens; D005971:Glutamates; D007073:Immunoglobulin E; D011794:Quercetin; D005978:Glutathione; D008239:Lysine