RNA splicing generates a variant light chain from an aberrantly rearranged kappa gene.
Both C kappa regions in MPC 11 cells are rearranged into active transcripion units, one producing a normal kappa chain and the other an internally deleted kappa fragment lacking a V region. The gene coding for the kappa fragment mRNA is aberrantly rearranged and lacks a site for V leads to C kappa splicing. An alternative splicing event which deletes the V region from the nuclear RNA precursor generates the kappa fragment mRNA.
D000818:Animals; D001483:Base Sequence; D005796:Genes; D007127:Immunoglobulin Constant Regions / Q000235:genetics; D007147:Immunoglobulin Light Chains / Q000235:genetics*; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D051379:Mice; D008970:Molecular Weight; D009194:Myeloma Proteins / Q000235:genetics*; D009694:Nucleic Acid Precursors / Q000235:genetics*; D011061:Poly A / Q000378:metabolism; D012332:RNA, Heterogeneous Nuclear / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics*; D014158:Transcription, Genetic
D007127:Immunoglobulin Constant Regions; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D009194:Myeloma Proteins; D009694:Nucleic Acid Precursors; D012332:RNA, Heterogeneous Nuclear; D012333:RNA, Messenger; D011061:Poly A