The effect of CO2-breathing on cochlear blood flow.
The cochlear blood flow was measured with the microsphere methods, before and during CO2-inhalation, in anesthetized rabbits. Different gas mixtures and exposure times were used. The greatest increase of cochlear blood flow was measured after 5 min inhalation of 7% CO2 in air (115%) and the least increase (44%) in animals breathing 7% CO2 in oxygen. The difference is explained as due to a vasoconstriction caused by a high oxygen tension counteracting the vasodilating effect of CO2.
D000142:Acidosis, Respiratory / Q000503:physiopathology; D000818:Animals; D002245:Carbon Dioxide / Q000494:pharmacology*; D003051:Cochlea / Q000098:blood supply*; D010100:Oxygen / Q000494:pharmacology; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D012119:Respiration
D002245:Carbon Dioxide; D010100:Oxygen