Amelioration by muramyl dipeptide of the effect of induced hyperferremia upon Klebsiella infection in mice.
Induced hyperferremia enhanced local Klebsiella infection, with and without a surgical suture as a test foreign body. Both bacterial proliferation and death occurred often in mice treated with ferric ammonium citrate. Muramyl dipeptide significantly protected animals from local bacterial growth, death, and, to some extent, bacteremia.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000494:pharmacology*; D000818:Animals; D007501:Iron / Q000097:blood*; D007710:Klebsiella Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000254:growth & development; D008297:Male; D051379:Mice; D009132:Muscles / Q000382:microbiology; D018805:Sepsis / Q000517:prevention & control
D000119:Acetylmuramyl-Alanyl-Isoglutamine; D007501:Iron