[Haemagglutinins and adhesins of Escherichia coli strains isolated from urine: inhibitory effect of sub-inhibitory concentrations of tetracycline, doxycycline and minocycline. Preliminary results ].
The present work concerned the study of the sub-minimal inhibitory doses of tetracyclin, doxycyclin and minocyclin on both hemagglutinating activity and adhesion capacity demonstrated in three E. coli strains isolated from urine. Two different types of hemagglutinins, mannose-resistant (HAMR) and mannose-sensitive (HAMS), were associated in two strains; HAMR was present in the third strain. Adhesion capacity was detected, in vitro, with uroepithelial cells spontaneously eliminated in urine. Whatever the antibiotic used, HAMR titers clearly decreased. In contrast, the effect of these antibiotics on the HAMS titers was inconstant, according to the bacterial strain or the antibiotic used. Adhesion capacity was inhibited particularly in the presence of tetracyclin and doxycyclin. Minocyclin was not a very good inhibitor molecule. The analysis of coefficient of correlation showed that the ability of adhering to uroepithelial cells was related to the HA titers. But it is impossible to say if the same bacterial structure migt be considered as mediator for both HA and adhesion capacity.
D000268:Adhesiveness; D004318:Doxycycline / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects* / Q000276:immunology / Q000302:isolation & purification; D006388:Hemagglutinins / Q000032:analysis*; D006801:Humans; D008911:Minocycline / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology; D013754:Tetracyclines / Q000494:pharmacology*; D014551:Urinary Tract / Q000166:cytology; D014552:Urinary Tract Infections / Q000382:microbiology
D006388:Hemagglutinins; D013754:Tetracyclines; D013752:Tetracycline; D008911:Minocycline; D004318:Doxycycline
Hémagglutinines et adhésines des Escherichia coli isolés des urines. Effet inhibiteur du chlorhydrate de tétracycline, de doxycycline et de minocycline à concentrations sub-inhibitrices. Résultats préliminaires.