Treatment of advanced gastric cancer with 5-fluorouracil versus mitomycin C.
Thirty-eight patients of advanced adenocarcinoma of the stomach were randomly administered intensive courses of either 5-FU or mitomycin C by intravenous route, The 5-FU administration resulted in a slightly better response than mitomycin C, although the toxic effects of the two drugs were more or less the same. The selection of drug regime in the present study has been based on cost, availability, potential toxicity, and minimal alteration of the patients' life style.
D000230:Adenocarcinoma / Q000188:drug therapy*; D000328:Adult; D002986:Clinical Trials as Topic; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008937:Mitomycins / Q000009:adverse effects / Q000627:therapeutic use*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000188:drug therapy*
D008937:Mitomycins; D005472:Fluorouracil