[In vitro and in vivo antimicrobial activities of cefmetazole against Bacteroides fragilis].
Cefmetazole was investigated on stability to beta-lactamases produced by Bacteroides fragilis and on therapeutic effects in mice infected with B. fragilis. 1. Cefmetazole, like other cephamycins, was found extremely stable to beta-lactamases obtained from B. fragilis. 2. Cefmetazole showed good antimicrobial activities to 50 strains of B. fragilis and extremely high stability to their beta-lactamases. 3. Cefmetazole showed an excellent protecting effect to infections due to beta-lactamase producing B. fragilis. 4. Cefmetazole exhibited an excellent chemotherapeutic effect against polymicrobial infections in mice due to E. coli (beta-lactamase -)and B. fragilis (beta-lactamase +).
D000818:Animals; D001442:Bacteroides Infections / Q000188:drug therapy* / Q000517:prevention & control; D001441:Bacteroides fragilis / Q000187:drug effects* / Q000201:enzymology; D015311:Cefmetazole; D002511:Cephalosporins / Q000494:pharmacology*; D002513:Cephamycins / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004352:Drug Resistance, Microbial; D004355:Drug Stability; D004927:Escherichia coli Infections / Q000188:drug therapy; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D001618:beta-Lactamases / Q000096:biosynthesis
D002511:Cephalosporins; D002513:Cephamycins; D015311:Cefmetazole; D001618:beta-Lactamases