[Dexamethasone regulation of the prolactin release induced by vasoactive intestinal peptide (VIP)].
The regulation of prolactin (PRL) secretion induced by the vasoactive intestinal peptide (VIP) has been studied on purified male Rat Pituitary PRL cells obtained by means of velocity sedimentation at unit gravity. Dexamethasone (10(-9) M) in the incubation medium inhibits the stimulatory effect of VIP (10(-7) M) on PRL release. This result suggests that glucocorticoids play an important role in the regulation of VIP effects at the effects at the pituitary level.
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology*; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism*; D051381:Rats; D014660:Vasoactive Intestinal Peptide / Q000037:antagonists & inhibitors / Q000494:pharmacology*
D005768:Gastrointestinal Hormones; D014660:Vasoactive Intestinal Peptide; D003907:Dexamethasone; D011388:Prolactin
Régulation par la dexaméthasone de la libération de prolactine induite par le peptide vasoactif intestinal (VIP).