Haemoglobin D Los Angeles, D-beta +-thalassaemia, and D-beta o-thalassaemia. A report of two Canadian families.
The first 2 Canadian cases of combinations of Hb D Los Angeles and beta-thalassaemia were found in an Italian family and an East Indian family in Hamilton, Ont. The structure of the Hb D variant was identified by radioimmunoassay. The beta +-thalassaemia trait in the Italian family and the beta o-thalassaemia trait in the East Indian family were confirmed by studies of globin chain synthesis. Previous cases of Hb D-beta-thalassaemia were summarized and family studies of the 2 new cases were presented.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D006455:Hemoglobins, Abnormal / Q000032:analysis* / Q000096:biosynthesis / Q000235:genetics; D006579:Heterozygote; D006801:Humans; D007194:India; D007223:Infant; D007558:Italy; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D013789:Thalassemia / Q000097:blood / Q000235:genetics*
D006455:Hemoglobins, Abnormal