A gene of the immunoglobulin H-chain cluster controls the murine antibody response to pneumococcal polysaccharide type 14.
Mice of various strains were immunized with pneumococcal polysaccharide type 14 (pneumo-14), and their anti-pneumo-14 antibodies were measured by the Farr test. Mice of strains BALB/c, ST/b, NZB and CBA (Ig allotypes a, e or j) had 300-1700 ng of antibody nitrogen per millilitre of serum on day 7. The corresponding values for C57BL/Ka, RF or AKR mice (allotypes b, c or d) were 40-300 ng/ml. Two families of congenic strains were tested, one with the C57BL and the other with the BALB/c background genome. Their response was either high or low depending on the VH genes, and other gene loci had little effect on the concentration of anti-pneumo-14 antibodies.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis / Q000235:genetics*; D000917:Antibody Formation; D002874:Chromosome Mapping; D005260:Female; D005796:Genes; D007126:Immunoglobulin Allotypes / Q000235:genetics; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology*
D000907:Antibodies, Bacterial; D007126:Immunoglobulin Allotypes; D007143:Immunoglobulin Heavy Chains; D011135:Polysaccharides, Bacterial