[Changes in skin DNA in newborn rats due to betamethasone in the last phase of pregnancy (author's transl)].
In an extensive series of experimental studies the DNA content of the skin of pure Wistar inbred rats was investigated to see whether any change occurred in the skin DNA content when the dams were pretreated with 1 mg betamethasone/kg b.w. s.c. on the 18th and 19th days of pregnancy. The newborn rats (age: 1, 2, 4, 9, 12, 15 days old) were sacrificed and the dams treated between 7.30 and 8.30 a.m. in order to avoid possible variations of the results due to the diurnal cycle. During the observation period there was a linear decline of DNA content between 1-day and 15-day old rats. This true for the control group as well as the treated animals. The finding that the DNA content in this tissue dropped in the first few days of life as a result of prenatal glucocorticoid application is of great importance.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001623:Betamethasone / Q000494:pharmacology*; D004247:DNA / Q000032:analysis*; D005260:Female; D011247:Pregnancy; D051381:Rats; D012867:Skin / Q000032:analysis / Q000187:drug effects*
D004247:DNA; D001623:Betamethasone
Veränderungen des Haut-DNA-Gehaltes neugeborener Ratten durch Betamethason in der letzten Phase der Schwangerschaft.