[Suppression of parasitemia in rodent filariasis (Litomosoides carinii) by immunization with BCG and microfilaria. I. Intracutaneous inoculation of BCG].
After intracutaneous inoculation of BCG and challenge by subcutaneous injection of infective larvae of Litomosoides carinii, the parasitaemia of the filarial infection in cotton rats remains significantly lower when BCG and larvae are applied in the region of the same popliteal and ileal lymph nodes. However, when the infective larvae are directed to other regional lymph nodes (Ln cubitales and axillares), the depression of microfilaraemia is missed. The worm load (recovery rate) and the expulsion of microfilariae by the adult worms are not influenced by the BCG inoculation. Obviously BCG stimulates the lymphatic tissue unspecifically, and the infective larvae produce the first antigen contact, which is boostered by the microfilariae at the onset of patency. When the intracutaneous BCG inoculation is combined with specific antigen stimulation by simultaneous injection of blood microfilariae in the region of the same lymph nodes, the microfilaraemia of the challenge infection disappears completely or remains extremely low.
D000818:Animals; D003411:Arvicolinae; D001500:BCG Vaccine / Q000276:immunology*; D001769:Blood / Q000469:parasitology; D005368:Filariasis / Q000276:immunology* / Q000469:parasitology; D005370:Filarioidea / Q000276:immunology*; D007114:Immunization; D008198:Lymph Nodes / Q000276:immunology; D008842:Microfilariae / Q000276:immunology
D001500:BCG Vaccine
Unterdrückung der Parasitämie bei der Nagetierfilariose (Litomosoides carinii) durch Immunisierung mit BCG und Mikrofilarien. I. Intrakutane Applikation von BCG.