[Level of polysomes in cells of Escherichia coli treated with sublethal doses of aminoglycosides].
Polysome level was measured in Escherichia coli cells grown in the presence of sublethal doses of four different aminoglycosides which all induce mistranslation: streptomycin, neomycin, kanamycin and gentamycin. No significant variation was noticed as referred to the level of polysomes in normally growing cells. This observation indicates that the erroneous incorporation of amino acids into polypeptide chains does not necessarily result in the release of ribosomes from messenger RNA molecules.
D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D004926:Escherichia coli / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D011132:Polyribosomes / Q000187:drug effects / Q000378:metabolism*; D014176:Protein Biosynthesis / Q000187:drug effects
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents
Etude du niveau des polysomes dans les cellules d'Escherichia coli traitées par des doses sublétales d'aminoglycosides.