[Increased vascular permeability during endotoxinemia in the child (author's transl)].
There is no uniform agreement about the effects of bacterial endotoxins upon vascular permeability. We presently report some clinical observations indicating an increase in vascular permeability during sepsis and shock related to Neisseria meningitidis in children. 133 children, admitted for a severe infection due to Neisseria m. were separated into three groups according to the severity of the initial clinical picture. The patients presenting with a sepsis or shock had significantly lower mean plasma protein levels on admission. This was not related to any hemodilution or caloric deficiency. Hypoproteinemia worsened during the 24 first hours of treatment, despite hemoconcentration as presented by some patients [12]. The speed of decrease in protein concentrations was inversely related to the molecular weights of the different protein fractions. These observations indicate an increase in vascular permeability with maintainance of vascular membrane selectivity to macromolecules during early meningococcic septicemia and shock.
D001798:Blood Proteins / Q000032:analysis; D002199:Capillary Permeability; D002648:Child; D004731:Endotoxins / Q000097:blood*; D006801:Humans; D009345:Neisseria meningitidis; D018805:Sepsis / Q000097:blood / Q000503:physiopathology*; D012772:Shock, Septic / Q000097:blood / Q000503:physiopathology
D001798:Blood Proteins; D004731:Endotoxins
Accroissement de la perméabilité vasculaire lors de l'endotoxinémie chez l'enfant.