Search for the most practical regular/NPH mixtures for type I diabetic patients.
After 2 wk of good control 9 type I diabetic patients were hospitalized and treated in a randomized fashion with different human insulin mixtures (regular: NPH), containing 10, 15, or 20% regular insulin. In the case of the 15:85% mixture, mean blood glucose was found to be in the range of 70-150 mg/dl. Significant differences occurred at certain time points between the curves obtained with the 10:90% and the 15:85% mixtures, and the 10:90% and the 20:80% preparations, respectively. Prolongation of the interval between hormone injection and start of breakfast from 30 to 45 min abolished the postprandial glucose excursion in the 15:85% and the 20:80% mixture, but not the 10:90% mixture.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D007336:Insulin, Isophane / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D004338:Drug Combinations; D007328:Insulin; D007336:Insulin, Isophane