Influence of exogenous estrogen on oocytic depletion induced by 7,12-dimethylbenz[alpha]anthracene in mice.
The influence of exogenous estrogen on the action of 7,12-dimethylbenz[alpha]anthracene (DMBA) on ovaries of Swiss albino mouse has been studied. DMBA elicits the depletion of oocytes; but concomitant administration of estrogen with DMBA reduces this loss of oocytic population significantly.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D004958:Estradiol / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D051379:Mice; D009865:Oocytes / Q000187:drug effects*; D010053:Ovary / Q000187:drug effects; D010063:Ovum / Q000187:drug effects*
D001551:Benz(a)Anthracenes; D004958:Estradiol; D015127:9,10-Dimethyl-1,2-benzanthracene