Effect of Escherichia coli endotoxin-mediated inflammation of one mammary quarter of the bovine udder on diapedesis into other quarters.
Implantation of 1 microgram Escherichia coli endotoxin into one papillary duct of a bovine udder frequently resulted in a mild inflammatory process in the treated quarter which was measured by use of the Wisconsin mastitis test (WMT) on quarter fore milk samples. Inflammation of a fore quarter was usually (18/24) accompanied by a transient elevation in WMT score from the homolateral hind quarter, but rarely (1/25) from the contralateral quarter. Inflammation in a hind quarter rarely (2/26) affected the homolateral fore quarter and never (0/25) the contralateral quarter. The pattern of responses suggests tha absorption and initial removal of endotoxin from the mammary gland occurs via the lymphatic rather than the blood system.
D000818:Animals; D002417:Cattle; D002465:Cell Movement; D004731:Endotoxins / Q000633:toxicity; D004926:Escherichia coli; D005260:Female; D007962:Leukocytes / Q000502:physiology; D008321:Mammary Glands, Animal / Q000503:physiopathology*; D008414:Mastitis, Bovine / Q000139:chemically induced / Q000503:physiopathology*; D008892:Milk / Q000166:cytology
D004731:Endotoxins