[Treatment of bovine mastitis during the dry period and development of intramammary drug formulations].
Studied were the factors that govern the pharmacokinetics of the intracysternal introduction of therapeutic means into the dry udder (type of drug base, physical and chemical properties of the drugs themselves and the physiologic and functional status of the gland). It is stated that the development of intramammary drug formulas for cows in a dry period is a difficult and complex activity as it is associated with the requirement to overcome two main conditions that could hardly be combined from the standpoint of biopharmacy and pharmacology. These consist in that the need of high concentrations to produce a therapeutic effect is connected with the presence of active ingredients that can be readily released from the base, while the need of producing also of a prophylactic effect imposes the persistence of these concentrations in the glandular secretion, and this means that the active matter should be slowly released. There is no chemotherapeutic agent by now that could properly satisfy all these requirements in order to prepare intramammary drug formulations for dry cows. It is believed, therefore, that at present the need for such therapeutic means can be met through the modulation of the medicinal bases and the physical and chemical properties of the drugs themselves which are offered by the pharmaceutic industry.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000378:metabolism; D002417:Cattle; D002626:Chemistry, Pharmaceutical; D004339:Drug Compounding; D005260:Female; D007267:Injections; D007700:Kinetics; D008321:Mammary Glands, Animal / Q000378:metabolism; D008414:Mastitis, Bovine / Q000188:drug therapy* / Q000378:metabolism
D000900:Anti-Bacterial Agents
Lekuvane na mastitite po kravite prez sukhostoĭniia period i problemi pri suzdavaneto na intramamarni lekarstveni formi.