[Pharmacokinetics of insulin and glucose during insulin infusions to diabetes patients. I. Basal regimen].
The model of the vascular bed is presented. With this model, pharmacokinetics of insulin and glucose in diabetics is studied while insulin is infused through a dispenser. Calculations have shown the simulation of prostatic activity function by the insulin dispenser leads to hypoinsulinism in the hepatic vascular bed and to hyperinsulinism in the remaining vascular bed. Insulin supply through the dispenser to any part of the vascular bed, in order to provide normal insulin concentration, is followed by changing in insulin concentration in the another areas of the vascular bed as well as fluctuating of the blood sugar level. So far, to normalize the blood sugar level by means of the current therapeutic methods with the insulin infuser is impossible because the sites of its administration does not topographically fit to normal insulin delivery into the vascular bed.
D001481:Basal Metabolism; D001786:Blood Glucose / Q000378:metabolism*; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy; D006801:Humans; D007328:Insulin / Q000097:blood*; D007332:Insulin Infusion Systems; D007700:Kinetics; D008954:Models, Biological
D001786:Blood Glucose; D007328:Insulin
Farmakokinetika insulina i gliukozy pri infuzionnom vvedenii insulina bol'nym diabetom. I. Bazal'nyĭ rezhim.