3-Alkyl(aryl)-piperazinoalkyl derivatives of 5,5-diphenylhydantoin.
The new obtained N3-alkyl- or arylpiperazinoalkyl substituted derivatives of 5,5-diphenylhydantoin weakly affect the spontaneous motility and the hypermotility induced by amphetamine. They did not show the anticonvulsive activity. Compounds containing the methyl (or phenyl)-piperazine moiety connected by the three-carbon chain with the N3 atom of the hydantoin ring show the strongest activity in the potentiation of the central effect of DOPA.
D002492:Central Nervous System Depressants / Q000138:chemical synthesis*; D004295:Dihydroxyphenylalanine / Q000494:pharmacology; D004357:Drug Synergism; D010672:Phenytoin / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D010879:Piperazines / Q000138:chemical synthesis; D013329:Structure-Activity Relationship
D002492:Central Nervous System Depressants; D010879:Piperazines; D010672:Phenytoin; D004295:Dihydroxyphenylalanine