[Longterm effect and maintenance therapy with cutaneous isosorbide dinitrate in patients with coronary heart disease (author's transl)].
The aim of this study was to examine the duration of action of a single cutaneous application of a 10% isosorbide dinitrate ointment (ISDN-S) and also to ascertain the possible appearance of nitrate tolerance after 6--8 months' maintenance therapy with ISDN-S. After a single application of the ointment an effect lasting more than 7 hours was confirmed by bicycle ergometry. After longterm therapy an acute test with rapidly acting sublingual ISDN produced an undiminished response thus showing lack of nitrate tolerance.
D003327:Coronary Disease / Q000188:drug therapy*; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D006801:Humans; D007548:Isosorbide Dinitrate / Q000627:therapeutic use*; D009824:Ointments
D009824:Ointments; D007548:Isosorbide Dinitrate
Langzeitwirkung und Dauertherapie mit kutan appliziertem Isosorbiddinitrat bei Patienten mit koronarer Herzkrankheit.