Bactericidal activity of serum for Klebsiella rhinoscleromatis: studies on serum from a patient with rhinoscleroma and sera deficient in antibody or complement.
The in-vitro bactericidal effect of serum for Klebsiella rhinoscleromatis was tested. Experiments with C2-deficient and hypogammaglobulinaemic human sera suggested that killing depended on activation of the classical complement pathway, although the alternative pathway probably amplified the effect. Serum from a patient with active rhinoscleroma, and another cured of the disease, showed normal killing.
D000361:Agammaglobulinemia / Q000276:immunology*; D001770:Blood Bactericidal Activity; D003175:Complement C2 / Q000172:deficiency*; D006099:Granuloma / Q000276:immunology*; D006801:Humans; D007710:Klebsiella Infections / Q000276:immunology*; D007711:Klebsiella pneumoniae / Q000276:immunology / Q000378:metabolism; D009302:Nasopharyngeal Diseases / Q000276:immunology*
D003175:Complement C2