The stimulation by ethanol of rat aorta ring prostacyclin-like synthesis is related to the age of the animal.
Rat aorta rings were incubated with Tris/HCl buffer and the release of prostacyclin-like material (PGI2-L) measured indirectly by assaying the increase in cAMP in rat platelets incubated with the aorta incubation medium. The addition of 1% ethanol to the incubation system stimulated PGI2-L formation. Aorta rings from 16 week old rats synthesised more PGI2-L material than aorta tissue removed from 6 week old animals.
D000367:Age Factors; D000818:Animals; D001011:Aorta / Q000378:metabolism*; D001095:Arachidonic Acids / Q000378:metabolism; D011464:Epoprostenol / Q000096:biosynthesis*; D000431:Ethanol / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains
D001095:Arachidonic Acids; D011453:Prostaglandins; D000431:Ethanol; D011464:Epoprostenol