A dual mechanism regulates the insulin stimulation of hepatic malic enzyme.
The activity of malic enzyme, an important hepatic lipogenic enzyme, is stimulated in diabetic rats by insulin administration. This process was shown to involve increases in both enzyme quantity and the specific activity (units activity/nmol enzyme) of the enzyme. Therefore, the coupling of these two regulatory mechanisms was responsible for the insulin-mediated increase in malic enzyme activity.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D005260:Female; D007328:Insulin / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008291:Malate Dehydrogenase / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains
D007328:Insulin; D008291:Malate Dehydrogenase