Ventilatory response to hypercapnia in normal subjects after propranolol, metoprolol and oxprenolol.
Steady state ventilatory response curves to CO2 were taken in 8 normal subjects in control situations and taking clinical doses of propranolol, oxprenolol and metoprolol in a double-blind crossover design. Furthermore, the expiratory peak flow was measured. No effect was found of any of the beta-blockers on the resting ventilatory parameters, the sensitivity to CO2 or the peak flow values.
D000328:Adult; D002245:Carbon Dioxide / Q000097:blood; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology*; D008297:Male; D008448:Maximal Expiratory Flow Rate; D008790:Metoprolol / Q000494:pharmacology*; D010096:Oxprenolol / Q000494:pharmacology*; D011412:Propanolamines / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects*
D011412:Propanolamines; D002245:Carbon Dioxide; D010096:Oxprenolol; D011433:Propranolol; D008790:Metoprolol