Tick-borne fever: leucocyte migration inhibition.
When sheep were infected with Cytoecetes phagocytophila the in vitro migration of peripheral leucocytes was reduced even when antigen was not added. The inhibition of migration coincided with parasitaemia and was due to soluble factors which inhibited the migration of leucocytes from normal sheep. After the cessation of parasitaemia addition of antigen was necessary for migration inhibition to occur.
D000818:Animals; D000942:Antigens, Bacterial; D002464:Cell Migration Inhibition; D005260:Female; D007961:Leukocyte Migration-Inhibitory Factors / Q000502:physiology*; D007962:Leukocytes / Q000276:immunology*; D008222:Lymphokines / Q000502:physiology*; D008297:Male; D012287:Rickettsiaceae / Q000276:immunology; D012288:Rickettsiaceae Infections / Q000276:immunology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology*
D000942:Antigens, Bacterial; D007961:Leukocyte Migration-Inhibitory Factors; D008222:Lymphokines