Mitogenic action of prolactin on the pancreatic islet cells in the chick.
A histological investigation was made to elucidate whether mammalian (ovine) prolactin can induce mitotic activity in pancreatic islet cell (in splenic lobe) of chicks. Prolactin treatment in different dosages (total dosage: 15, 50 and 100 IU per bird in 10 days) increased the mitotic frequency and also caused hypertrophy in the AF-positive cells of the B-islets in the splenic lobe. The increase in mitotic frequency was uniform for all doses applied. It is suggested that prolactin has a mitogenic action on the pancreatic islet cells of male chicks and that action is possibly not dose-dependent.
D000818:Animals; D002645:Chickens; D007515:Islets of Langerhans / Q000166:cytology / Q000187:drug effects*; D008934:Mitogens / Q000494:pharmacology*; D008938:Mitosis / Q000187:drug effects; D011388:Prolactin / Q000494:pharmacology*
D008934:Mitogens; D011388:Prolactin