The effects of U-40481, demethylchlordimeform, and formetanate on calcium flux in the isolated rabbit aorta.
The effects of three formamidine pesticide or pesticide metabolites on calcium flux in the rabbit aorta were examined. U-40481 reduced the rate of both 45Ca uptake and norepinephrine (NE)-stimulated 45Ca uptake into deadventitiated rabbit aorta strips and reduced NE-stimulated efflux from 45Ca-loaded, superfused aorta strips (p less than 0.1). Neither demethylchlordimeform nor formetanate altered either 45Ca-uptake or NE-enhanced 45Ca flux. The action of U-40481 on unstimulated 45Ca uptake may result from uncoupling oxidative phosphorylation, and reduction in NE-induced 45Ca-flux may result from antagonism at NE receptors.
D000578:Amidines / Q000494:pharmacology*; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D002219:Carbamates / Q000494:pharmacology*; D002742:Chlorphenamidine / Q000031:analogs & derivatives / Q000494:pharmacology*; D066298:In Vitro Techniques; D007306:Insecticides / Q000494:pharmacology*; D008353:Mannitol / Q000378:metabolism; D009638:Norepinephrine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D011817:Rabbits; D013997:Time Factors; D014018:Tissue Distribution
D000578:Amidines; D002132:Calcium Radioisotopes; D002219:Carbamates; D007306:Insecticides; C011741:demethylchlordimeform; C025699:U 40481; D008353:Mannitol; C100163:formetanate; D002742:Chlorphenamidine; D011188:Potassium; D002118:Calcium; D009638:Norepinephrine