Increase in coagulation factor VIII activity in man following acute hypoglycaemia: mediation via an adrenergic mechanism.
Coagulation factor VIII activity has been assayed in nine normal volunteers before and after acute hypoglycaemia. In all subjects there was a rise in activity with a mean increment of 96%. Control studies using saline failed to demonstrate any change. In four subjects with pre-ganglionic sympathetctomy no increase in activity was observed. In the normal subjects the increase was blocked by propranolol but not by metoprolol, indicating mediation via beta2 receptors.
D000208:Acute Disease; D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects; D005169:Factor VIII / Q000502:physiology*; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000097:blood*; D008297:Male; D008790:Metoprolol / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D013562:Sympathectomy
D005169:Factor VIII; D011433:Propranolol; D008790:Metoprolol