Endogenous renin inhibitor in neuroblastoma cells.
Cloned neuroblastoma cells (Neuro-2a) in culture were found to contain a renin inhibitory substance. The inhibitor in the extract of cloned neuroblastoma cells was separated from renin activity by anti-renin IgG-Sepharose and selectively concentrated by adsorption to renin-agarose gel. The present study demonstrated the coexistence of renin and its inhibitor in the same cell and suggested a possible regulatory mechanism of intracellular renin activity by an endogenous renin inhibitor in neuronal cells.
D000818:Animals; D002460:Cell Line; D051379:Mice; D009374:Neoplasms, Experimental / Q000378:metabolism; D009447:Neuroblastoma / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D009842:Oligopeptides / Q000378:metabolism*; D000092502:Renin Inhibitors
D009842:Oligopeptides; D000092502:Renin Inhibitors; C027509:renin inhibitory peptide