Transcapillary exchange and retention of fluoride, strontium, EDTA, sucrose, and antipyrine in bone.
The extractions of 85Sr2+, 18F-, sucrose-14C, EDTA-51Cr, and antipyrine-14C in bone were determined by the multiple indicator-dilution method. Fluoride and strontium extractions were 18 to 70% during a single transcapillary passage, and those of EDTA and sucrose were from 11 to 59%, whereas extraction of antipyrine was 87%. Injections of 85Sr2+ and 18F- made when perfusion was done alternately with blood and plasma resulted in similar fractional extractions. When flow and extraction were measured simultaneously, extraction was related inversely to flow.
D000818:Animals; D000983:Antipyrine / Q000008:administration & dosage / Q000378:metabolism*; D001842:Bone and Bones / Q000378:metabolism*; D002199:Capillary Permeability; D004285:Dogs; D004492:Edetic Acid / Q000008:administration & dosage / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism; D005459:Fluorides / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D013324:Strontium / Q000008:administration & dosage / Q000378:metabolism*; D013395:Sucrose / Q000008:administration & dosage / Q000378:metabolism*
D013395:Sucrose; D004492:Edetic Acid; D005459:Fluorides; D000983:Antipyrine; D013324:Strontium