Prostaglandin synthetase activity in vascular tissue of male and female rats.
1. Isolated perfused lungs from mature male rats show greater conversion of 14C Arachidonic Acid to cyclo-oxygenase products than females. 2. Following unlabelled arachidonate infusion, the male lungs release more 6-K-PGF1 alpha and TxB2 than females. 3. Aortic rings from male rats release more PGI2-like material and 6-K-PGF1 alpha than the females. 4. These data indicate an elevated PG synthetase activity in male rats as compared with females.
D015121:6-Ketoprostaglandin F1 alpha; D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism*; D001095:Arachidonic Acids / Q000494:pharmacology; D004971:Estrus; D005260:Female; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011247:Pregnancy; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D011460:Prostaglandins F / Q000378:metabolism / Q000494:pharmacology; D011863:Radioimmunoassay; D051381:Rats; D013929:Thromboxane B2 / Q000378:metabolism
D001095:Arachidonic Acids; D011460:Prostaglandins F; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D011451:Prostaglandin-Endoperoxide Synthases