Combined gentamicin-tobramycin-corticosteroid treatment. II. Effect on gentamicin-resistant Pseudomonas keratitis.
In an experimental model of Pseudomonas keratitis produced by a gentamicin sulfate-resistant, tobramycin sulfate-sensitive strain of P aeruginosa, the results of two treatment regimens-(1) with gentamicin and tobramycin alone and (2) with gentamicin, tobramycin, and a steroid-were evaluated. All of the animals exhibited ultimately the same amount of corneal inflammation and corneal scarring. In the group receiving the antibiotic-steroid combination, the corneal lesions healed more slowly.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage*; D007634:Keratitis / Q000188:drug therapy* / Q000209:etiology; D008297:Male; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa; D011817:Rabbits; D013997:Time Factors; D014031:Tobramycin / Q000008:administration & dosage*; D014222:Triamcinolone Acetonide / Q000008:administration & dosage*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D014222:Triamcinolone Acetonide; D014031:Tobramycin