Prevention of postoperative tubal adhesions. Comparative study of commonly used agents.
Tubal abrasions were surgically induced in 25 rhesus monkeys following demonstration of tubal patency. Five monkeys received dexamethasone, promethazine, and ampicillin perioperatively, five received intraperitoneal 10% dextran 40, five received intraperitoneal 32% dextran 70, and 10 received no additional therapy. Fimbrial biopsies were obtained from two additional monkeys treated with 32% dextran 70 before and postoperatively on days 2, 5, and 7. Only those treated with 32% dextran 70 retained tubal patency and avoided development of adhesions, involving fimbria, omentum, ovary, uterus, and bladder. Histologic examination of fimbrial biopsies demonstrated sufficient epithelial repair to have occurred during the 5 days 32% dextran 70 remained in the pelvin cavity to prevent adhesion formation.
D000667:Ampicillin / Q000627:therapeutic use*; D000818:Animals; D001706:Biopsy; D003907:Dexamethasone / Q000627:therapeutic use*; D003911:Dextrans / Q000627:therapeutic use*; D005184:Fallopian Tube Diseases / Q000473:pathology / Q000517:prevention & control*; D005186:Fallopian Tube Patency Tests; D005260:Female; D000882:Haplorhini; D008253:Macaca mulatta; D011183:Postoperative Complications / Q000517:prevention & control*; D011398:Promethazine / Q000627:therapeutic use*; D000267:Tissue Adhesions
D003911:Dextrans; D000667:Ampicillin; D003907:Dexamethasone; D011398:Promethazine