Mutagenic activity of 3 diazoacetylglycine derivatives on V79 Chinese hamster cells.
3 diazoacetylglycine derivatives, diazoacetylglycine amide (DGA), diazoacetylglycine ethyl ester (DGE) and diazoacetylglycine hydrazide (DGH), known as antitumour agents, and shown to be mutagenic in bacteria, were studied for their mutagenic activity in the HGPRT system of V79 Chinese hamster cells in culture (V79/HGPRT system). All 3 drugs were highly effective in inducing 6-thioguanine-resistant mutants at concentrations that were not significantly cytotoxic.
D000818:Animals; D001391:Azo Compounds / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival; D006224:Cricetinae; D003412:Cricetulus; D004351:Drug Resistance; D005347:Fibroblasts / Q000187:drug effects; D005998:Glycine / Q000031:analogs & derivatives / Q000494:pharmacology*; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D009152:Mutagenicity Tests; D009153:Mutagens; D013866:Thioguanine
D001391:Azo Compounds; D009153:Mutagens; C000908:N-diazoacetylglycine hydrazide; C026767:ethyl diazoacetylglycinate; D007041:Hypoxanthine Phosphoribosyltransferase; D013866:Thioguanine; D005998:Glycine