[Effect of the administration of nucleotide coenzymes on the lipogenic enzyme changes caused by chronic alcohol intoxication].
Lipogenic enzymes glucose-6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, isocitrate dehydrogenase NADP+ soluble and malic enzyme have been determined in the hepatic soluble fraction of rats chronically treated with ethanol and a lipid rich diet. The treatment based on protectives and lipotropic substances administered as nucleotides: UDP-glucose, CDP-choline, S-adenosyl methionine and Coenzyme A, elicits a significant restoration on the activities of G6PDH, 6PGDH and ICDH. These results show that the treatment, on promoting lipid mobilization, could increase the rate of hepatic lipogenesis. The malic enzyme enhanced activities, when ethanol and lipid diet were simultaneously administered, may be interpreted as a requirement for NADPH by the microsomic drug oxidation system.
D000429:Alcohol Oxidoreductases / Q000378:metabolism*; D000437:Alcoholism / Q000201:enzymology*; D000818:Animals; D002794:Choline / Q000031:analogs & derivatives*; D003065:Coenzyme A / Q000494:pharmacology*; D003566:Cytidine Diphosphate Choline / Q000494:pharmacology*; D004041:Dietary Fats / Q000008:administration & dosage; D006801:Humans; D050356:Lipid Metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012436:S-Adenosylmethionine / Q000494:pharmacology*; D014532:Uridine Diphosphate Glucose / Q000494:pharmacology*; D014539:Uridine Diphosphate Sugars / Q000494:pharmacology*
D004041:Dietary Fats; D014539:Uridine Diphosphate Sugars; D003566:Cytidine Diphosphate Choline; D012436:S-Adenosylmethionine; D000429:Alcohol Oxidoreductases; D002794:Choline; D003065:Coenzyme A; D014532:Uridine Diphosphate Glucose
Efecto de la administración de coenzimas nucleotídicos sobre las variaciones de enzimas lipogénicos orginadas por intoxicación etílica crónica.