[A precursor of phospholipids in the treatment of severe traumatic comas].
CDP Choline, a metabolic precursor of phospholipids, has been tested against placebo in a controlled randomized double blind study concerning 60 cases of severe head injuries (wide-spread cerebral contusions and/or severe concussion). In the treated group, a shortening of the comatose period and an acceleration of neurological deficits recovery have been observed. These results are tentatively attributed to an effect of the drug against brain edema, already documented on experimental models.
D000328:Adult; D000368:Aged; D001930:Brain Injuries / Q000150:complications*; D002794:Choline / Q000031:analogs & derivatives*; D002986:Clinical Trials as Topic; D003128:Coma / Q000188:drug therapy* / Q000209:etiology; D003566:Cytidine Diphosphate Choline / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013997:Time Factors
D003566:Cytidine Diphosphate Choline; D002794:Choline
Etude d'un précurseur des phospholipides dans le traitement des comas traumatiques graves.