Hydroxyamino acid utilization and alpha-ketobutyrate toxicity in Pseudomonas cepacia.
Growth of Pseudomonas cepacia 249 on D-threonine required a mutation to permit D-hydroxyamino acid deaminase formation and L-valine to overcome alpha-ketobutyrate toxicity. Strain 249 lacked a second D-hydroxyamino acid deaminase formed by other strains.
D002087:Butyrates / Q000633:toxicity*; D007651:Keto Acids / Q000633:toxicity; D012695:L-Serine Dehydratase / Q000378:metabolism; D011549:Pseudomonas / Q000378:metabolism*; D012694:Serine / Q000378:metabolism*; D013912:Threonine / Q000378:metabolism*; D013913:Threonine Dehydratase / Q000378:metabolism; D014633:Valine / Q000378:metabolism
D002087:Butyrates; D007651:Keto Acids; D013912:Threonine; D012694:Serine; C005087:alpha-ketobutyric acid; D012695:L-Serine Dehydratase; D013913:Threonine Dehydratase; D014633:Valine