Constitutional delay of growth and adolescence.
In order to evaluate possible abnormalities among males with constitutional delay of growth and adolescence, hormonal responses and interrelationships have been extensively evaluated in a young man with a documented history of this condition and compared with young men with a history of normal puberty as controls. Normal hypothalamic-pituitary sensitivity to circulating sex steroids and a normal end-organ response (nitrogen and phosphorus retention) to testosterone stimulation were found. There was, however, a decreased gonadal (testosterone) response to gonadotropin (HCG) stimulation and a decreased pituitary response to clomiphene stimulation. These decreased responses could explain the observed adolescent delay in growth and maturation observed in these individuals.
D000328:Adult; D006063:Chorionic Gonadotropin; D002996:Clomiphene / Q000031:analogs & derivatives; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006130:Growth Disorders / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D011628:Puberty, Delayed / Q000097:blood*; D013739:Testosterone / Q000097:blood*
D006063:Chorionic Gonadotropin; D002996:Clomiphene; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone