Use of whole blood exchange transfusion to supply neutrophils to septic, neutropenic neonates.
When neutropenia due to exhaustion of the marrow neutrophil reserve, develops in a neonate with bacterial sepsis the likelihood of survival is very small. We report such a case who was treated with a double-volume exchange transfusion using fresh unstored whole blood. We were able to determine a net gain of 5 x 10(8) neutrophils per kg. Then, in neutropenic neonatal animals, neutrophil transfusion by double-volume exchange transfusion with unstored blood was investigated.
D000380:Agranulocytosis / Q000628:therapy*; D000818:Animals; D000831:Animals, Newborn; D004195:Disease Models, Animal; D004285:Dogs; D004927:Escherichia coli Infections / Q000150:complications*; D005078:Exchange Transfusion, Whole Blood; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000628:therapy*; D009503:Neutropenia / Q000209:etiology / Q000628:therapy*; D009504:Neutrophils