Fertility after discontinuation of oral contraceptives.
Concern has been expressed regarding fertility following oral contraceptive (Pill) use. A review of the literature indicates that there is a slight delay in the return of fertility in Pill users but no permanent impairment results. A small proportion of women experience a prolonged period of amenorrhoea following cessation of combined oral contraception, but whether the Pill plays an aetiological role is doubtful since there appear to be no differences in endocrine profiles amongst women with amenorrhoea following Pill use and those with secondary amenorrhoea who have never used oral contraceptives. Factors which may predispose to amenorrhoea following Pill use are: late onset of menarche, previous oligomenorrhoea and low body weight. Following adequate investigation and treatment, fertility rates in women with the so-called post-Pill amenorrhoea syndrome return to normal. There is no evidence of any delay in the return of fertility in women who use the progestogen-only Pill.
D000027:Abortion, Incomplete / Q000139:chemically induced; D000328:Adult; D000568:Amenorrhea / Q000139:chemically induced / Q000503:physiopathology; D001835:Body Weight; D002869:Chromosome Aberrations / Q000139:chemically induced; D025063:Chromosome Disorders; D003274:Contraceptive Devices, Female; D003276:Contraceptives, Oral / Q000008:administration & dosage* / Q000009:adverse effects; D036861:Delivery, Obstetric; D005260:Female; D005298:Fertility / Q000187:drug effects*; D006801:Humans; D007231:Infant, Newborn; D010060:Ovulation / Q000187:drug effects*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000139:chemically induced; D045167:Progesterone Congeners / Q000008:administration & dosage; D011388:Prolactin / Q000097:blood; D013577:Syndrome; D013997:Time Factors
D003276:Contraceptives, Oral; D045167:Progesterone Congeners; D011388:Prolactin