Comparison of the activity of some fasciolicides against immature liver fluke in calves.
The anthelmintic activities of nitroxynil, closantel and rafoxanide were tested in cattle against six- and eight-week-old infections of Fasciola hepatica. Administered by subcutaneous injection, nitroxynil and rafoxanide at dose rates of 10 and 3 mg/kg bodyweight respectively were 88.5 and 36.1 per cent effective in eliminating a six-week-old infection of F hepatica and 85.8 and 60.4 per cent effective against an eight-week-old infection. Closantel administered by intramuscular injection at a dose rate of 2.5 mg/kg bodyweight was 60.0 per cent effective against an eight-week-old F hepatica infection.
D000818:Animals; D000871:Anthelmintics / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases / Q000188:drug therapy* / Q000469:parasitology; D002986:Clinical Trials as Topic / Q000662:veterinary; D005210:Fasciola hepatica; D005211:Fascioliasis / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D008099:Liver / Q000469:parasitology; D009611:Nitroxinil / Q000627:therapeutic use; D011888:Rafoxanide / Q000627:therapeutic use; D012458:Salicylanilides / Q000627:therapeutic use
D000871:Anthelmintics; D012458:Salicylanilides; D011888:Rafoxanide; D009611:Nitroxinil; C023342:closantel