A possible role for lipoxygenase products as regulators of airway smooth muscle reactivity.
The size of guinea-pig isolated tracheal contractions induced by histamine was substantially augmented by pretreatment with the cyclo-oxygenase inhibitor, indomethacin. However, compounds which inhibit both the cyclo-oxygenase and lipoxygenase pathways of arachidonic acid metabolism not only did not augment histamine-induced contractions of the guinea-pig trachea, but also completely reversed the increased reactivity to histamine produced by indomethacin. The SRS-A (slow reacting substance of anaphylaxis) antagonist, FPL55712, and the anti-allergic drug, cromoglycate, had no effect on the augmentation of histamine-induced contractions by indomethacin.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology*; D008084:Lipoxygenase / Q000502:physiology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D010105:Oxygenases / Q000037:antagonists & inhibitors; D013189:SRS-A / Q000502:physiology; D014132:Trachea / Q000187:drug effects* / Q000502:physiology
D001095:Arachidonic Acids; D013189:SRS-A; D006632:Histamine; D010105:Oxygenases; D008084:Lipoxygenase; D007213:Indomethacin