[Effect of long-term exposure to thiophosphamide on the frequency of chromosome aberrations in Chinese hamster cell cultures].
The paper contains the results of the study on the frequency of chromosome aberrations in the cell culture of Chinese hamster under a prolonged action of low concentrations of thiophosphamide (Thph). The frequency of chromosome aberrations in the initial period somewhat increases and then keeps to a certain constant level independently on the duration of action of thiophosphamide. With the heightening of the concentration of the chemical, a sharp increase in the number of chromosome aberrations is observed, which leads to a mass dying of the cell culture. These results may be interpreted as the action of the selection against mutant cells.
D000818:Animals; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D004305:Dose-Response Relationship, Drug; D009153:Mutagens; D009154:Mutation; D012641:Selection, Genetic; D013852:Thiotepa / Q000009:adverse effects*; D013997:Time Factors
D009153:Mutagens; D013852:Thiotepa
Chastota khromosomnykh aberratsiĭ v kul'ture kletok kitaĭskogo khomiachka pri dlitel'nom vozdeĭstvii tiofosfamida.