[Comparative study of the neurotropic and hormonal activity of thyrotropin releasing hormone and its analogs].
Comparative study of hormonal and antihypnotic activity of thyrotropine releasing hormone (TRH) and of its two analogues: pyroglutamine-serine-leucine amide (A-1) and pyroglutamine-serine-glycine amide (A-2) was carried out on male rats. Along with hormonal activity, TRH possessed distinct antagonistic action against nembutal, diminishing its toxicity. In the group of control animals given nembutal and physiological saline the LD50 for nembutal constituted 5.75 mg/100 g. Administration of TRH in a dose of 0.5 mg/kg increased this index to 8.0 mg/100 g, and in a dose of 1 mg/kg--to 11 mg/100 g. The analogues under study failed to influence the TRH secretion of the hypophysis, but differed in respect to their action on nembutal: A-1 decreased nembutal toxicity more intensively than TRH, whereas A-2 was ineffective. The problem of the neutropic action of TRH and A-1 is discussed.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D004336:Drug Antagonism; D006728:Hormones / Q000494:pharmacology; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology*; D010424:Pentobarbital / Q000037:antagonists & inhibitors / Q000494:pharmacology / Q000633:toxicity; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D013268:Stimulation, Chemical; D013972:Thyrotropin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D006728:Hormones; D009842:Oligopeptides; C019070:pyroglutamyl-seryl-glycinamide; D013973:Thyrotropin-Releasing Hormone; C024667:pyroglutaminyl-seryl-leucinamide; D013972:Thyrotropin; D010424:Pentobarbital; D011761:Pyrrolidonecarboxylic Acid
Sravnitel'noe issledovanie neĭrotropnoĭ i gormonal'noĭ aktivnosti tereotropin-rilizing-gormona i ego analogov.