Dopamine metabolism in human brain: effect of monoamine oxidase inhibition in vitro by (-)deprenyl and (+) and (-) tranylcypromine.
The effects of the monoamine oxidase inhibitors (-)deprenyl and (+)-and (-)tranylcypromine on dopamine oxidation in human caudate have been investigated. Oxidation of dopamine has been found to exhibit both (-)deprenyl-sensitive and -insensitive components. The tranylcypromine isomers are both more sensitive towards dopamine than 5-hydroxytryptamine oxidation, (+) isomer being the more effective of the two. These results are discussed in terms of the in vivo action of the drugs and their therapeutic value.
D000368:Aged; D001921:Brain / Q000378:metabolism*; D002421:Caudate Nucleus / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D006801:Humans; D010084:Oxidation-Reduction; D010627:Phenethylamines / Q000494:pharmacology*; D012642:Selegiline / Q000494:pharmacology*; D013237:Stereoisomerism; D014191:Tranylcypromine / Q000494:pharmacology*
D010627:Phenethylamines; D012642:Selegiline; D014191:Tranylcypromine; D004298:Dopamine