Monoamine oxidase inhibitors potentiate phenylethylamine effects in rhesus monkeys.
Acute pretreatment with either a Type A monoamine oxidase inhibitor (MAOI), clorgyline, or a Type B MAOI, pargyline, markedly reduced the dose of phenylethylamine (PEA) required to produce checking and a variety of other behavioral changes in rhesus monkeys. Doses of PEA (5 or 10 mg/kg) which previously were without effect, now produced significant behavioral changes in pretreatment animals.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003010:Clorgyline / Q000494:pharmacology*; D000882:Haplorhini; D006801:Humans; D008253:Macaca mulatta; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010293:Pargyline / Q000494:pharmacology*; D010627:Phenethylamines / Q000494:pharmacology*; D011292:Premedication; D011437:Propylamines / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects
D010627:Phenethylamines; D011437:Propylamines; D010293:Pargyline; D003010:Clorgyline