H-Y antigen and sex determination in animals.
In all instances described, H-Y antigen was found when testes were present. Extragonadal tissues in androgen-insensitive individuals with TFS were typed H-Y+, indicating that this cell surface component is hormone-independent. Thus, association of H-Y antigen and primary sex determination is reinforced. But variation in the degree of masculinization observed in certain mammalian intersexes (e.g., polled goats) is not explained by simple H-Y antigen dosage effects. Additional genetic and/or intrauterine modifiers may influence both gonadal and somatic tissue target cell sensitivity to hormones.
D013734:Androgen-Insensitivity Syndrome / Q000235:genetics; D000818:Animals; D002369:Castration; D012734:Disorders of Sex Development / Q000235:genetics / Q000662:veterinary*; D004283:Dog Diseases / Q000235:genetics; D004285:Dogs; D005260:Female; D006041:Goats; D006084:Graft Rejection; D006182:H-Y Antigen; D006801:Humans; D008297:Male; D051379:Mice; D051381:Rats; D012376:Rodent Diseases / Q000235:genetics; D012733:Sex Differentiation; D016038:Skin Transplantation; D013552:Swine; D013553:Swine Diseases / Q000235:genetics
D006182:H-Y Antigen