[Use of an osmotic minipump for the study of thyroxine deiodination in the rat].
Thyroidectomized Rats were implanted with an osmotic minipump delivering a continuous but small amount of T4 (2 microgram/100 g/day), mimicking therefore thyroid secretion. This experimental procedure allows a normal serum T3 level to be maintained by peripheral deiodination of T4.
D000818:Animals; D001711:Biotransformation; D004343:Drug Implants; D008297:Male; D051381:Rats; D013965:Thyroidectomy; D013974:Thyroxine / Q000097:blood / Q000378:metabolism*; D014284:Triiodothyronine / Q000097:blood / Q000378:metabolism
D004343:Drug Implants; D014284:Triiodothyronine; D013974:Thyroxine
Utilisation d'une minipompe osmotique pour l'étude de la désiodation de la thyroxine chez le Rat.