Infectivity dissociated from transforming activity in a human retrovirus, adult T-cell leukemia virus.
Adult T-cell leukemia virus (ATLV)-associated antigen was induced in normal human peripheral or cord lymphocytes by inoculation of cell-free ATLV from a producer line, MT-2. Induction of the antigen was much more efficient, when the cells were treated with phytohemagglutinin before infection. Most ATLV-specific antigen (ATLA)-positive cells induced by ATLV in peripheral lymphocytes formed rosettes with sheep erythrocytes, but 20 to 40% of those induced in cord lymphocytes were not rosette-forming cells. Continuous proliferation of ATLA-positive cells was not observed.
D000328:Adult; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000956:Antigens, Viral; D002472:Cell Transformation, Viral; D005312:Fetal Blood / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007938:Leukemia / Q000209:etiology*; D009858:Oncogenic Viruses / Q000276:immunology; D010835:Phytohemagglutinins / Q000494:pharmacology; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*; D014412:Tumor Virus Infections / Q000209:etiology*
D000911:Antibodies, Monoclonal; D000956:Antigens, Viral; D010835:Phytohemagglutinins