Effects of furosemide on cardiovascular function and performance when given prior to simulated races: a double-blind study.
In a double-blind study under simulated racing conditions, six Standardbred horses, which had been trained for 12 weeks, were given 1 mg of furosemide/kg of body weight or saline solution IV 15 minutes before the first of two warm-up workouts (1.6 km at 60-minute intervals). Sixty minutes later, 135 minutes after drug or placebo injection, these horses were driven 1.6 km at maximum speed. Heart rate, respiratory rate, cardiac output, pulmonary trunk pressure, body temperature, PCV, arterial oxygen, and plasma lactic acid were recorded during and after the first warm-up workout and after a simulated race (1.6 km). Values increased compared with values determined at rest whether saline solution or furosemide was given. There were decreases in arterial CO2 and pH. When furosemide was given, the pulmonary trunk pressure was significantly lower (P < 0.05) during the first warm-up workout (1.6 km). There were no significant differences in the other values. The average times of the simulated races were not significantly (P < 0.05) different after the use of furosemide compared with average times after use of saline solution.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002245:Carbon Dioxide / Q000097:blood; D002302:Cardiac Output / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D004311:Double-Blind Method; D005665:Furosemide / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006736:Horses / Q000502:physiology*; D010100:Oxygen / Q000097:blood; D005082:Physical Exertion; D011651:Pulmonary Artery / Q000187:drug effects; D012119:Respiration / Q000187:drug effects
D002245:Carbon Dioxide; D005665:Furosemide; D010100:Oxygen