Effects of perhexiline on contractile response of rabbit aorta to norepinephrine and potassium.
Perhexiline (3.2 X 10(-7)-6.4 X 10(-6) M) and verapamil (2 X 10(-8)-2 X 10(-7) M) inhibited the contraction of rabbit aorta induced with 40 mM K+ and with low concentrations (5.9 X 10(-9)-5.9 X 10(-8) M) of norepinephrine more effectively than the contraction induced by higher concentrations of norepinephrine. The tension induced by 1.2 X 10(-6) M norepinephrine was augmented with the above concentrations of perhexiline and verapamil. Higher concentrations (3.2 X 10(-5)-6.4 X 10(-5) M) of perhexiline significantly reduced the peak tension induced by norepinephrine. The results suggest that perhexiline is a Ca2+ antagonist and also has an unspecific spasmolytic action.
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D004347:Drug Interactions; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D005996:Nitroglycerin / Q000494:pharmacology; D009638:Norepinephrine / Q000502:physiology*; D010480:Perhexiline / Q000494:pharmacology*; D010880:Piperidines / Q000494:pharmacology*; D011188:Potassium / Q000502:physiology*; D011817:Rabbits; D014700:Verapamil / Q000494:pharmacology
D010880:Piperidines; D014700:Verapamil; D005996:Nitroglycerin; D010480:Perhexiline; D011188:Potassium; D009638:Norepinephrine