Increased deposition of 111Indium labelled platelets in chronically rejected kidney transplants.
Increased deposition of 111In-oxine labelled autologous platelets in chronically rejected kidney transplants was demonstrated using a gamma-camera and by measurement of a platelet uptake index (PUI). In this group of patients the PUI correlated indirectly with the platelet half-life and was statistically different from the PUI found in stable transplant patients who acted as controls. It is therefore suggested that platelets may play a key role in chronic rejection by the release of a mitogenic factor which promotes the development of obliterative arterial lesions in the transplant.
D000328:Adult; D001792:Blood Platelets / Q000000981:diagnostic imaging / Q000502:physiology*; D005260:Female; D005921:Glomerulonephritis / Q000628:therapy; D006084:Graft Rejection; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging / Q000502:physiology; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging