[The hypothalamo-hypophyseo-ovarian systems in rats after deafferentiation of the mediobasal hypothalamus].
Complete surgical deafferentation of the medio-basal hypothalamus (MBH) in rats entails suppression of the oestrus cycle as well as a decrease of luteinizing hormone, estrogens and progesterone release into the blood due to a sharp fall of the luliberine content in the median eminence and arquate nuclei. No connection was revealed between the character of oestrus disturbances and the extent of damage or isolation of the arquate, ventromedial, supraoptic and paraventricular nuclei and the amount of Homori-positive neurosecreted in the MBH. In development of permanent diestrus the MBH isolation was more complete than in the preservation of irregular cycle. The luliberine seems to be produced mainly in the anterior hypothalamus of rats whereas the MBH alone fails to maintain even its tonic secretion. Even in complete surgical isolation of the MBH, separate fibers of the luliberinergic cells penetrate into the MBH maintaining there a certain amount of luliberin and preserving synthesis of the luteinizing hormone in the hypophysis with its decreased release into the blood.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000344:Afferent Pathways / Q000293:injuries; D000818:Animals; D001923:Brain Chemistry; D003714:Denervation; D004971:Estrus; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D007028:Hypothalamic Hormones / Q000032:analysis / Q000378:metabolism; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology*; D007031:Hypothalamus / Q000032:analysis; D007033:Hypothalamus, Middle / Q000502:physiology*; D007986:Luteinizing Hormone / Q000032:analysis / Q000097:blood; D009489:Neurosecretion; D010053:Ovary / Q000502:physiology*; D010902:Pituitary Gland / Q000032:analysis; D011247:Pregnancy; D051381:Rats
D007028:Hypothalamic Hormones; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D006916:5-Hydroxytryptophan
Gipotalamo-gipofizarno-ovarial'naia sistema u krys posle deafferentatsii medio-bazal'nogo gipotalamusa.