Aspects of the neuroendocrine bases of the diurnal metabolic cycle in rats.
The difference between nocturnal and diurnal glucose disappearance rate, glucose stimulated insulin release and insulin sensitivity has been studied in normal adult female rats. The glucose clearance rate measured after an IV injection of glucose (1 g/kg) was found to be slower during the day than at night. However, due to the non-physiological level of hyperglycemia induced, the insulinogenic index failed to reveal a difference in glucose stimulated insulin release. On the contrary, the hypoglycemic response to an IV injection of 0.5 IU/kg of insulin indicated a higher insulin sensitivity and tissue glucose uptake at night compared to the day. The results are discussed with respect to the role of the neuroendocrine diurnal pattern underlying the diurnal periodicity of feeding.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002940:Circadian Rhythm; D005247:Feeding Behavior / Q000502:physiology; D005260:Female; D005947:Glucose / Q000494:pharmacology; D007328:Insulin / Q000097:blood*; D051381:Rats; D011919:Rats, Inbred Strains
D001786:Blood Glucose; D007328:Insulin; D005947:Glucose