[Bactericidal activity of antibiotics as a function of pharmacokinetic constants. I. Experimental dynamic model simulating variations in the concentrations of antibiotics].
In order to study the bactericidal effect of antibiotics in a system approaching actual therapy, a dynamic model which simulates concentration variations was developed. This was done using a dialysis intermediary. Three aminoglycosides (amikacin, gentamicin, tobramycin) were taken in a system resembling the serum rates of the normal individual. The apparatus is fairly accurate, the variation coefficients being of the order of 10 to 14%. This model enables the simulation of numerous therapeutic situations. It is however limited to only dialysable antibiotics.
D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D003956:Dialysis; D007700:Kinetics; D008956:Models, Chemical
D000900:Anti-Bacterial Agents
Activité bactéricide des antibiotiques en fonction des constantes pharmacocinétiques. I.--Modèle expérimental dynamique simulant les variations des concentrations des antibiotiques.