[Fluorine uptake by calcified tissues in the guinea pig after 18 months exposure to an atmosphere containing 100 to 150 mcg hydrofluoric acid per cubic meter].
In the conditions described, inhaled HF is uptaken progressively by bones and teeth. Metabolic processes involved in calcification are disturbed and serum alkaline phosphatase activity is increased. The transfer of fluoride ion through placenta is revealed by an increase of bone fluorine in newborne Guinea Pigs issued from intoxicated mothers.
D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D000831:Animals, Newborn; D001842:Bone and Bones / Q000378:metabolism*; D005260:Female; D005461:Fluorine / Q000378:metabolism*; D006168:Guinea Pigs; D006858:Hydrofluoric Acid / Q000378:metabolism*; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012119:Respiration; D014070:Tooth / Q000378:metabolism*
D005461:Fluorine; D000469:Alkaline Phosphatase; D006858:Hydrofluoric Acid
Etude de la fixation du fluor au niveau des tissus calcifiés chez le Cobaye après 18 mois d'exposition à une atmosphère renfermant 100 à 150 microgram d'acide fluorhydrique par mètre cube.