Increase in circulating basement membrane antigens in diabetic rats and effects of insulin treatment.
The serum concentrations of two recently discovered antigens derived from basement membranes (7-S collagen and laminin P2) were assayed in streptozotocin-diabetic rats as possible indicators of basement membrane metabolism. The concentrations of both increased significantly after 8 weeks of diabetes, and that of 7-S collagen at least remained elevated up to 24 weeks. Treatment with insulin, which did not correct the metabolic disturbances, inhibited the increase in the concentration of 7-S collagen in serum, but did not completely normalize that of laminin P2.
D000818:Animals; D000941:Antigens / Q000032:analysis*; D001485:Basement Membrane / Q000276:immunology*; D001786:Blood Glucose / Q000032:analysis; D003094:Collagen / Q000276:immunology; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy / Q000276:immunology*; D006023:Glycoproteins / Q000276:immunology; D007328:Insulin / Q000627:therapeutic use*; D007797:Laminin; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000941:Antigens; D001786:Blood Glucose; D006023:Glycoproteins; D007328:Insulin; D007797:Laminin; D003094:Collagen