Xylazine hydrochloride-induced hyperglycemia and hypoinsulinemia in thoroughbred horses.
The effects of intravenous xylazine (1.1 mg/kg) were studied in six thoroughbred horses (five mares and a stallion). Plasma glucose concentration increased to 168% of control at 45 min and decreased to 112% of control at 180 min. Insulin had decreased to 31% of control at 15 min. Thereafter, insulin concentration increased, reaching its highest concentration at 150 min. The mechanism for these changes is not fully understood and further investigation is indicated.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D006736:Horses / Q000097:blood*; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous / Q000662:veterinary; D007328:Insulin / Q000097:blood*; D008297:Male; D013843:Thiazines / Q000494:pharmacology*; D014991:Xylazine / Q000008:administration & dosage / Q000494:pharmacology*
D001786:Blood Glucose; D006993:Hypnotics and Sedatives; D007328:Insulin; D013843:Thiazines; D014991:Xylazine