Inability of styrene to induce nondisjunction in Drosophila or a positive micronucleus test in the Chinese hamster.
Styrene produced no effect on induction of sex-chromosome nondisjunction in Drosophila melanogaster fed on 500 ppm styrene for 24 h. No increase in the frequency of micronuclei from chromosome fragments or from nondisjunction of whole chromosomes was seen in the bone marrow of Chinese hamsters (Cricetulus griseus) injected (i.p.) with a single dose of 1.0 g/kg b.wt. styrene or with 250 mg/kg b.wt. of the primary metabolite, styrene oxide.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D004331:Drosophila melanogaster; D005260:Female; D008297:Male; D009153:Mutagens; D012730:Sex Chromosomes / Q000187:drug effects*; D013343:Styrenes / Q000378:metabolism / Q000633:toxicity*
D009153:Mutagens; D013343:Styrenes