Suppression of GVH reaction in F1 hybrid mice by foetal liver cells.
The effect of foetal liver cells on GVH reaction with the parental lymphocytes in F1 hybrid mice was studied. The GVH reaction was induced in newborn (CBA X C3H)F1 and in 10-day-old (CBA X C57BL/6)F1 hybrid mice. Foetal liver cells did not induce a GVH reaction. The GVH reaction of CBA spleen cells in (CBA X C3H)F1 hybrid mice was demonstrable, although weak. Foetal liver cells suppressed the GVH reaction, in dependence on cell concentration, in (CBA x C3H)F1 but not in (CBA X C57BL/6)F1 hybrid mice. The possibility to induce transplantation tolerance with foetal liver cells is discussed.
D000818:Animals; D000831:Animals, Newborn; D003433:Crosses, Genetic; D005260:Female; D005333:Fetus; D006087:Graft vs Host Reaction; D007165:Immunosuppression Therapy; D008099:Liver / Q000196:embryology; D016031:Liver Transplantation; D017710:Lymphocyte Transfusion; D051379:Mice; D008815:Mice, Inbred Strains; D011247:Pregnancy; D013154:Spleen / Q000276:immunology