[Effect of a synthetic analog of enkephalin on the choreic syndrome].
A cross-over, double-blind intravenous administration of a single dose of FK 33-824, a rigid analog of enkephalin, was performed in 12 choreic patients (0,5 mg in 6 patients, 2 mg in 6 patients). The number of abnormal involuntary movements per minute and their amplitude was not altered after FK 33-824 when compared to placebo administration. This result however does not exclude the possibility of a functional interaction between Met-enkephalinergic and dopaminergic systems in the human brain.
D000328:Adult; D000368:Aged; D002819:Chorea / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin; D004311:Double-Blind Method; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged
D004744:Enkephalin, Methionine; D005405:D-Ala(2),MePhe(4),Met(0)-ol-enkephalin
Effet d'un analogue synthétique de l'enképhaline dans le syndrome choréïque.