[Hematopoietic stroma and the regulation of hematopoiesis in extramedullary bone marrow transplants in mice].
The bone marrow fragments were transplanted under the renal capsule and "stromal function" of the transplants during up to 1.5 years was estimated by the numbers of CFU-S, myelokaryocytes and the weight of newly formed bone tissue. On the basis of the published and authors' data, a conclusion was drawn that the ability of the stromal precursor cells of bone marrow to provide for the growth of hemopoietic territories is limited by the size of medullary cavity; outside its limits this ability is not only realized, but may be additionally stimulated by some distant factors (preirradiation of the recipients in the given case). The self-maintenance ability of the stromal mechanocytes from the old mice during 43 months was shown by means of retransplantation. On the basis of electron microscopy and published data, a suggestion was put forward that fibroblastic reticular cells might be ancestral elements of osteogenic differentiation.
D000818:Animals; D001345:Autoradiography; D016026:Bone Marrow Transplantation; D003114:Colony-Forming Units Assay; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008854:Microscopy, Electron; D013997:Time Factors
Krovetvornaia stroma i reguliatsiia krovetvoreniia v ékstramedulliarnykh transplantatakh kostnogo mozga u mysheĭ.