Interaction between phenytoin and valproate.
Displacement of phenytoin from plasma proteins by valproate causes a reduction in total serum phenytoin levels. However, no adjustment of phenytoin dosage is warranted, unless clinically indicated, since the free phenytoin levels remain unchanged.
D001798:Blood Proteins / Q000378:metabolism; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000188:drug therapy; D006801:Humans; D010672:Phenytoin / Q000008:administration & dosage / Q000097:blood*; D011485:Protein Binding / Q000187:drug effects; D014635:Valproic Acid / Q000008:administration & dosage / Q000494:pharmacology*
D001798:Blood Proteins; D014635:Valproic Acid; D010672:Phenytoin