Anti-hypoxic effect of prostacyclin.
The anti-hypoxic effect of prostacyclin (PGI2) was studied using the following methods: hypoventilation hypoxia and hypovolemic oligemia in cats and hypobaric hypoxia and complete ischemia by decapitation in mice. In experiments on cats PGI2 (250 ng/kg/min i.v.) led to an improvement of hypoxia-impaired EEG activity. In hypobaric hypoxia, PGI2 at all doses applied (50-500 micrograms/kg) led to a significant increase in the survival time (from 67.5% to 196%). In complete ischemia by decapitation, PGI2 at doses from 50 to 500 micrograms/kg significantly prolonged the gasping movements (from 7.8% to 20.6%). Different mechanisms of the anti-hypoxic effect of PGI2 are discussed. The effect observed would be potentially beneficial in hypoxic and ischemic states.
D000818:Animals; D001274:Atmospheric Pressure; D002415:Cats; D004569:Electroencephalography; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D000860:Hypoxia / Q000188:drug therapy*; D007511:Ischemia / Q000503:physiopathology; D008297:Male; D011453:Prostaglandins / Q000494:pharmacology*; D012769:Shock / Q000503:physiopathology
D011453:Prostaglandins; D011464:Epoprostenol