Reduction of venous thrombosis complicating phlebography.
Patients who underwent radiographic phlebography were studied to determine the frequency of postphlebographic venous thrombosis. In a group of 23 patients who had negative phlebograms performed with standard contrast agent (60% sodium methylglucamine diatrizoate), nine had positive 125I-fibrinogen leg scans. On repeat phlebography, three had confirmed deep vein thrombosis, six overall developed deep or superficial thrombosis, and three had positive scans without demonstrable thrombi. In a second group of 34 patients studied with the contrast material diluted to 45%, only three developed positive scans, one due to deep venous thrombosis and two to superficial thrombosis. There was also a reduction in the incidence of postphlebographic symptoms of pain, tenderness, and erythema, but no apparent sacrifice in diagnostic accuracy.
D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000008:administration & dosage* / Q000009:adverse effects; D006801:Humans; D007866:Leg / Q000098:blood supply*; D010690:Phlebography / Q000009:adverse effects*; D011152:Popliteal Vein; D012501:Saphenous Vein; D013927:Thrombosis / Q000139:chemically induced / Q000453:epidemiology / Q000517:prevention & control*
D003973:Diatrizoate; D003974:Diatrizoate Meglumine