Effects of thioridazine and withdrawal dyskinesias on workshop performance of mentally retarded young adults.
The authors conducted a two-part study of the effects of thioridazine and withdrawal dyskinesias on the workshop performance of mentally retarded young adults. In part 1, 80 mentally retarded subjects were divided into five groups of 16 according to administration, discontinuation, or nonadministration of thioridazine. The major finding was that thioridazine can impair the workshop performance of mentally retarded individuals. In part 2, 28 subjects were divided into four matched groups of 7 subjects each whose thioridazine dose was abruptly or gradually discontinued and who did or did not have withdrawal dyskinesias. Workshop performance declined with the onset of the dyskinesias and improved as the dyskinesias subsided.
D000293:Adolescent; D000328:Adult; D004409:Dyskinesia, Drug-Induced / Q000209:etiology / Q000523:psychology*; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000188:drug therapy / Q000523:psychology / Q000534:rehabilitation*; D008297:Male; D009048:Motor Skills / Q000187:drug effects; D012050:Rehabilitation, Vocational; D013375:Substance Withdrawal Syndrome / Q000209:etiology / Q000523:psychology*; D013647:Task Performance and Analysis; D013881:Thioridazine / Q000008:administration & dosage / Q000009:adverse effects*
D013881:Thioridazine