Lack of genotoxic activity of 2-(2',4'-diaminophenoxy)ethanol in Escherichia coli strains WP2, WP2uvrA and WP2uvrA/recA.
A new hair-dyeing ingredient, 2-(2',4'-diaminophenoxy)ethanol, was tested for its genotoxic potential with Escherichia coli WP2, WP2uvrA and WP2uvrA/recA. The tests were conducted in the presence and absence of a post-mitochondrial supernatant fraction from the livers of male rats induced with Aroclor 1254. Tests for DNA damage and repair and tests for mutagenic activity failed to demonstrate any genotoxic potential associated with the compound.
D000818:Animals; D001711:Biotransformation; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D006202:Hair Dyes / Q000494:pharmacology*; D006203:Hair Preparations / Q000494:pharmacology*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D010655:Phenylenediamines / Q000494:pharmacology*; D051381:Rats; D013045:Species Specificity
D006202:Hair Dyes; D006203:Hair Preparations; D009153:Mutagens; D010655:Phenylenediamines; C032556:2-(2',4'-diaminophenoxy)ethanol