[Effect of glibenclamide on the ultrastructure of the islands of Langerhans and their insulin content].
The ultrastructure of the pancreatic islets and insulin content in the beta-cells, revealed by histochemical technique after glybenclamide loading, was investigated in rats. Glybenclamide administration led to the loss in beta-cells of a greater portion of their hormone depot. Ultrastructurally, a significant development in all the organellae of the protein synthesizing apparatus was demonstrated, this testifying to a sharp rise of the hormone production. At the same time insulin released from the cells was accelerated, although no final and complete formation of beta-granules occurred, alpha-insulocytes appeared to be intact.
D000818:Animals; D005905:Glyburide / Q000494:pharmacology*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000378:metabolism / Q000648:ultrastructure*; D008854:Microscopy, Electron; D011817:Rabbits; D013268:Stimulation, Chemical
D007328:Insulin; D005905:Glyburide
Vliianie glibenklamida na ul'trastrukturu pankreaticheskikh ostrovkov i soderzhanie v nikh insulina.