TRH on rat conditioned avoidance behavior: interaction with brain catecholamines.
TRH (10 micrograms) intracerebroventricularly injected improves the acquisition of a two-day avoidance conditioning. This effect is partially antagonized by pretreatment IP with alpha-methyltyrosine (60 mg/kg) or disulfiram (300 mg/kg). L-DOPA (100 mg/kg) administered IP 2 hr after alpha-MT partially restores the facilitatory effect of the hormone. The possible roles of brain catecholamines on the behavioral effect of TRH are analysed. Other tentative mechanisms of action are also discussed.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects*; D002395:Catecholamines / Q000378:metabolism*; D004295:Dihydroxyphenylalanine / Q000494:pharmacology; D004221:Disulfiram; D007276:Injections, Intraventricular; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*
D002395:Catecholamines; D008781:Methyltyrosines; D013973:Thyrotropin-Releasing Hormone; D004295:Dihydroxyphenylalanine; D004221:Disulfiram