Effect of Aroclor 1254 on leukocyte glucose uptake.
Uptake of glucose in human leukocytes was estimated by measuring incorporation of 14C-labeled 2-deoxyglucose (2-DG) into the cells. Exposure of lymphocytes and monocytes, but not neutrophils, to Aroclor 1254 (10 microM) caused a decreased 2-DG uptake. This method of measuring glucose uptake may be useful for detecting potential polychlorinated biphenyl (PCB) target cells.
D005947:Glucose / Q000378:metabolism*; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D011078:Polychlorinated Biphenyls / Q000494:pharmacology*
D011078:Polychlorinated Biphenyls; D005947:Glucose