Comparative enzyme-inducing effects of chlorpromazine and fluphenazine therapies in psychotic patients.
Antipyrine elimination kinetics were measured in psychotic patients receiving either long-term chlorpromazine or fluphenazine decanoate therapy and in non-medicated control subjects. Patients receiving chlorpromazine metabolised antipyrine faster than the controls while, in patients receiving fluphenazine decanoate, there was not change. The results suggest that long-term chlorpromazine therapy induced the activity of drug-metabolising enzymes, whereas fluphenazine decanoate therapy had no effect.
D000328:Adult; D000368:Aged; D000983:Antipyrine / Q000378:metabolism; D002746:Chlorpromazine / Q000494:pharmacology* / Q000627:therapeutic use; D004790:Enzyme Induction / Q000187:drug effects*; D005260:Female; D005476:Fluphenazine / Q000494:pharmacology* / Q000627:therapeutic use; D006207:Half-Life; D006801:Humans; D008099:Liver / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000188:drug therapy / Q000201:enzymology*
D005476:Fluphenazine; D000983:Antipyrine; D002746:Chlorpromazine