Conservative management of low grade neoplasms of the male urethra: a preliminary report.
Between 1965 and 1977, 8 men with low grade urethral neoplasms were treated with local excision or a combination of local excision and local chemotherapeutic agents. The tumors were in the anterior urethra in 5 cases and the posterior urethra in 3. Histology included 2 transitional cell papillomas, 3 squamous cell carcinomas, 1 transitional cell carcinoma, 1 mesonephric carcinoma and 1 intraductal transitional cell carcinoma in situ. All neoplasms were controlled by local measures for 1 to 13 years. This experience suggests that local treatment may be an acceptable alternative to a radical operation in certain well localized low grade urethral neoplasms in men.
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000628:therapy; D002295:Carcinoma, Transitional Cell / Q000628:therapy; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010212:Papilloma / Q000628:therapy; D013852:Thiotepa / Q000008:administration & dosage; D014521:Urethra / Q000601:surgery; D014523:Urethral Neoplasms / Q000601:surgery / Q000628:therapy*
D013852:Thiotepa; D005472:Fluorouracil