Possible influence of gonadotrophins on formation in vivo of pyridoxal phosphate.
FSH administered to normal rats increased the activity of pyridoxine phosphate oxidase of both liver and kidney and, consequently, pyridoxal phosphate levels in these tissues were elevated. LH administration, on the other hand, decreased the activity of pyridoxine phosphate oxidase, resulting in diminished pyridoxal phosphate level in the tissues. The stimulatory effect of FSH on the activity of liver and kidney pyridoxine phosphate oxidase was not observed in castrated-adrenalectomised rats unless supplemented with cortisone and testosterone, respectively. Puromycin treatment prevented the FSH-induced rise in the activity of liver and kidney pyridoxine phosphate oxidases. It is suggested that FSH stimulates the activity of liver and kidney pyridoxine phosphate oxidase by increasing the synthesis of apoproteins of the enzyme, and the effect of FSH on liver is dependent on the presence of adrenal corticoids while the presence of testosterone is a prerequisite for the FSH to have its effect on kidney pyridoxine phosphate oxidase.
D000315:Adrenalectomy; D000818:Animals; D002369:Castration; D005640:Follicle Stimulating Hormone / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D007986:Luteinizing Hormone / Q000494:pharmacology*; D008297:Male; D011732:Pyridoxal Phosphate / Q000378:metabolism*; D011734:Pyridoxaminephosphate Oxidase / Q000378:metabolism; D051381:Rats
D011732:Pyridoxal Phosphate; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D011734:Pyridoxaminephosphate Oxidase