Radiation dose from human platelets labelled with indium 111.
The biological distribution of 111In-labelled platelets in normal subjects was determined by whole-body counting and scintillation-camera computer-assisted imaging. Using these data, organ radiation dose was quantitated. The highest radiation dose of 7.4 mGy/MBq (27.4 rad/mCi) was received by the spleen and 0.97 mGy/MBq (3.6 rad/mCi) by the liver. While body radiation dose was 0.25 mGy/MBq (0.9 rad/mCi). The gonad radiation dose of males was 0.14 mGy/MBq  (0.5 rad/mCi) and that of females 0.22 mGy/MBq (0.8 rad/mCi). These estimates indicate that radiation doses received from 8.6 MBq of 111In-labelled platelets are well within acceptable limits, and that 111In is a safe labelling agent for the study of platelet kinetics.
D000328:Adult; D001792:Blood Platelets; D001853:Bone Marrow / Q000528:radiation effects; D005260:Female; D006801:Humans; D007204:Indium; D008099:Liver / Q000528:radiation effects; D008297:Male; D010053:Ovary / Q000528:radiation effects; D011829:Radiation Dosage; D011851:Radioactivity; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013154:Spleen / Q000528:radiation effects; D013737:Testis / Q000528:radiation effects; D014018:Tissue Distribution; D014915:Whole-Body Counting
D011868:Radioisotopes; D007204:Indium