Preliminary investigation on the central action of prostacyclin (PGI2) in rats.
Prostacyclin (PGI2) injected ivc in doses of 25 and 100 micrograms/rat increased body temperature, decreased spontaneous locomotor activity and amphetamine-induced locomotor hyperactivity in Wistar rats, in a dose of 100 micrograms inhibited apomorphine-induced stereotypy and potentiated haloperidol-induced catalepsy. PGI2 in both doses decreased noradrenaline level, in a dose of 100 micrograms it increased the cerebral level of dopamine but did not influence the utilization of these amines in the rat brain. PGI2 in a dose of 100 micrograms also increased the concentration of serotonin, but did not change the cerebral 5-hydroxyindoloacetic acid concentration.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D001921:Brain / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D011464:Epoprostenol / Q000494:pharmacology*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011453:Prostaglandins / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011453:Prostaglandins; D011464:Epoprostenol