Increase of collagen synthesis in pulmonary arteries of monocrotaline-treated rats.
Collagen synthesis in the pulmonary artery in animals with pulmonary hypertension was studied using monocrotaline-treated rats as a model. Incorporation of 14C-lateled proline into collagenase-digestible protein in the pulmonary artery was found to be 4-5 times higher in monocrotaline-treated rats than in control rats.
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D003094:Collagen / Q000096:biosynthesis*; D008297:Male; D016686:Monocrotaline; D011651:Pulmonary Artery / Q000187:drug effects / Q000378:metabolism*; D011763:Pyrrolizidine Alkaloids / Q000494:pharmacology*; D051381:Rats
D011763:Pyrrolizidine Alkaloids; D016686:Monocrotaline; D003094:Collagen