Lack of correlation between skin reactivity and T lymphocytes and monocytes in Hodgkin's disease.
28 untreated patients with Hodgkin's disease have been studied in respect to skin reactivity to purified protein derivative and dinitrochlorobenzene and blood monocytes and T lymphocytes. Cutaneous anergy as defined by unresponsiveness to both purified protein derivative and dinitrochlorobenzene was found in 43% of patients and in 7% of the control group. Although there was a significant reduction in E-rosetting lymphocytes in Hodgkin's cases, we found no differences in the mean numbers of E-rosetting lymphocytes and monocytes between normergic and anergic patients. We, therefore, conclude that skin reactivity is not directly correlated with the total numbers of E-rosetting lymphocytes or monocytes in Hodgkin's disease.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D006689:Hodgkin Disease / Q000276:immunology*; D006801:Humans; D007958:Leukocyte Count; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology*; D012397:Rosette Formation; D012867:Skin / Q000276:immunology*; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology*