The Shwartzman phenomenon in equine species.
The occurrence of the Local Shwartzman Reaction (LSR) in equine species has not previously been reported. The molecular mechanism appears identical to that reported for the rabbit and other species. The immunopathologic and histopathologic similarities of the experimentally induced LSR in horses and ponies to that of the hoof-laminae (an extension of the skin) lesion in naturally-occurring and/or carbohydrate induced laminitis may offer insight into the pathogenesis of this complex disease.
D000818:Animals; D001792:Blood Platelets / Q000473:pathology; D004731:Endotoxins / Q000008:administration & dosage; D005260:Female; D005337:Fibrin / Q000032:analysis; D005455:Fluorescent Antibody Technique; D006736:Horses / Q000097:blood*; D007249:Inflammation / Q000473:pathology; D008297:Male; D009336:Necrosis; D009504:Neutrophils / Q000473:pathology; D012790:Shwartzman Phenomenon / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D012867:Skin / Q000473:pathology
D004731:Endotoxins; D005337:Fibrin