[Sperm analysis of patients after long term use of hydantoin].
Sperm investigations of 35 epileptics being treated with hydantoin for a period of more than three years have shown that by a large dispersion of evaluations only 52% of the sperm cells were intact (teratozoospermia; compared with a normal limit of 60% p = 5%, of 70% p = 1%). The mobility of the sperm cells was 49% (asthenozoospermia; compared with a normal limit of 60% p = 5%). It is supposed to be a toxical damage caused by hydantoin as the gonadotropins and testosterone were mainly normal with a representative group of 8 persons.
D000293:Adolescent; D000328:Adult; D004827:Epilepsy / Q000188:drug therapy*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D006827:Hydantoins / Q000009:adverse effects* / Q000627:therapeutic use; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D012661:Semen / Q000187:drug effects; D013076:Sperm Count / Q000187:drug effects; D013094:Spermatozoa / Q000473:pathology*; D013739:Testosterone / Q000097:blood
D006827:Hydantoins; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Spermiogrammuntersuchungen bei Patienten unter Langzeitthydantoinbehandlung.