Prostaglandins alter the 3H-noradrenaline metabolism by the isolated rat uterus from ovariectomized animals.
The influence of prostaglandins (PGs) on the metabolism of 3H-noradrenaline in isolated uterine horns from ovariectomized rats exposed to acetylsalicylic acid was explored. PGE1 and PGE2 (10 nM) increased both the total tritium and the 3H-O-methylated deaminated metabolites from the spontaneous outflow. PGE2 augmented 3H-normetanephrine whereas PGE1 reduced the 3H-3, 4-dihydroxyphenylglycol fraction. The 3H-noradrenaline fraction from the spontaneous outflow of tritium was enhanced by PGE2 and PGI2 (10 nM). On the other hand PGF2 alpha (10 nM-1 microM) did not change the metabolism of 3H-noradrenaline. The present findings suggest a possible modulation of noradrenaline metabolism by some PGs on the isolated rat uterus from ovariectomized rats.
D000527:Alprostadil; D000818:Animals; D002369:Castration; D015232:Dinoprostone; D011464:Epoprostenol / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D008734:Methoxyhydroxyphenylglycol / Q000031:analogs & derivatives / Q000378:metabolism; D008745:Methylation; D009638:Norepinephrine / Q000378:metabolism*; D009647:Normetanephrine / Q000378:metabolism; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D011453:Prostaglandins; D011458:Prostaglandins E; D009647:Normetanephrine; D008734:Methoxyhydroxyphenylglycol; D011464:Epoprostenol; D000527:Alprostadil; D015232:Dinoprostone; C010117:3,4-dihydroxyphenylglycol; D009638:Norepinephrine