Beclomethasone nasal spray in the treatment of middle-ear effusion - a double-blind study.
The effect of a beclomethasone dipropionate nasal spray on middle ear effusion was tested in a double-blind study of drug vs placebo (vehicle). Seventy children, aged 4-14 years, sprayed each nostril twice daily for one month. Among them 35 received a daily dose of 400 micrograms of the beclomethasone. The results of tympanometry, audiometry and otomicroscopy were compared in the two groups, and the statistical analysis revealed P-values around 0.5. The conclusion is that the active drug had no effect on middle ear effusion in the population investigated.
D000158:Acoustic Impedance Tests; D000281:Administration, Intranasal; D000293:Adolescent; D001301:Audiometry, Pure-Tone; D001507:Beclomethasone / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010033:Otitis Media / Q000188:drug therapy*
D001507:Beclomethasone