Release of gastric inhibitory polypeptide and insulin in response to intrajejunal glucose in duodenal ulcer patients before and after truncal vagotomy.
Six duodenal ulcer patients were investigated before and 3 months after truncal vagotomy and pyloroplasty. Plasma concentrations of gastric inhibitory polypeptide (GIP), insulin, and glucose were measured during intrajejunal infusion of 50 g of glucose. The GIP response was significantly diminished postoperatively; insulin and glucose concentrations, however, were unchanged. The reduction of GIP release was positively correlated with the reduction of the peak acid output. The results suggest that a reduced vagal innervation of the intestine is accompanied by reduced GIP release after intrajejunal glucose, depending on the degree of completeness of vagotomy.
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D004381:Duodenal Ulcer / Q000097:blood / Q000503:physiopathology* / Q000601:surgery; D005260:Female; D005745:Gastric Acidity Determination; D005749:Gastric Inhibitory Polypeptide / Q000097:blood / Q000378:metabolism*; D005768:Gastrointestinal Hormones / Q000378:metabolism*; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007328:Insulin / Q000097:blood / Q000378:metabolism*; D000078790:Insulin Secretion; D007583:Jejunum; D008297:Male; D008875:Middle Aged; D014628:Vagotomy
D001786:Blood Glucose; D005768:Gastrointestinal Hormones; D007328:Insulin; D005749:Gastric Inhibitory Polypeptide; D005947:Glucose