Detection of antigonococcal IgA in cervical secretions by indirect immunofluorescence: an evaluation as a diagnostic test.
Using an indirect immunofluorescent-antibody method, antigonococcal IgA was detected in the cervical secretions of 56 (72%) of 78 women with untreated gonorrhoea but in only 25 (5%) of 490 non-infected women. The low sensitivity--comparable to that of Gram-stain microscopy--the expense, and the laboriousness of the test militate against its use as a routine diagnostic procedure.
D000907:Antibodies, Bacterial / Q000032:analysis; D001826:Body Fluids / Q000276:immunology; D002584:Cervix Uteri / Q000276:immunology* / Q000378:metabolism; D003276:Contraceptives, Oral; D005069:Evaluation Studies as Topic; D005260:Female; D005455:Fluorescent Antibody Technique; D006069:Gonorrhea / Q000175:diagnosis*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D009344:Neisseria gonorrhoeae / Q000276:immunology
D000907:Antibodies, Bacterial; D003276:Contraceptives, Oral; D007070:Immunoglobulin A