The source of follicular androgens in the hamster follicle.
The comparative ability of granulosa cells and theca of the hamster preovulatory follicle to produce androgens in vitro from endogenous and exogenous substrates was assessed. The results indicate that theca are the major source of follicular androstenedione, but that the granulosa cells may be the major source of follicular testosterone. Theca and granulosa cells accumulate comparable amounts of dihydrotestosterone from exogenous androstenedione and testosterone and both may be a significant source of follicular DHT. LH stimulates the conversion of progesterone and 17 alpha-OH progesterone to androstenedione, testosterone and DHT in theca. LH does not stimulate the conversion of androstenedione to testosterone or DHT, and that of testosterone to DHT in either granulosa cells or theca. FSH, in granulosa cells but not in theca, stimulates the conversion of adrostenedione to testosterone but it has no effect in DHT accumulation from exogenous testosterone.
D000728:Androgens / Q000096:biosynthesis*; D000735:Androstenedione / Q000378:metabolism; D000818:Animals; D006224:Cricetinae; D013196:Dihydrotestosterone / Q000096:biosynthesis; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D006107:Granulosa Cells / Q000187:drug effects / Q000378:metabolism; D006908:Hydroxyprogesterones / Q000378:metabolism; D007986:Luteinizing Hormone / Q000494:pharmacology; D008647:Mesocricetus; D006080:Ovarian Follicle / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D011359:Proestrus; D011374:Progesterone / Q000378:metabolism
D000728:Androgens; D006908:Hydroxyprogesterones; D013196:Dihydrotestosterone; D000735:Androstenedione; D011374:Progesterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone