[Metabolic interaction of valproic acid (author's transl)].
Valproic acid produces a marked competitive inhibition of the aminophenazone N-demethylation and the codeine phosphate O-demethylation by 9000 g-supernatant of rat liver homogenates, but it exerts virtually no effect on the aniline hydroxylation and the p-nitrophenol glucuronidation which are slightly inhibited only if its tenfold amount is allowed to react on the substrate.
D000632:Aminopyrine / Q000378:metabolism*; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D001667:Binding, Competitive; D003061:Codeine / Q000378:metabolism*; D003640:Dealkylation; D014453:Glucuronosyltransferase / Q000378:metabolism; D006900:Hydroxylation; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D014635:Valproic Acid / Q000494:pharmacology*
D000814:Aniline Compounds; D000632:Aminopyrine; D014635:Valproic Acid; D014453:Glucuronosyltransferase; D003061:Codeine
Metabolische Wechselwirkungen von Valproinsäure.