Ovum transport in the rhesus monkey following postovulatory intravaginal 15(S)-15-methyl prostaglandin F2 alpha-methyl ester administration.
The effects of postovulatory intravaginal 15(S)-15-methyl prostaglandin F2 alpha-methyl ester (Me PGF2 alpha) on ovum transport was assessed in the spontaneously ovulatory rhesus monkey. A single suppository containing 3.0 mg of Me PGF2 alpha in lipid base was inserted intravaginally in adult female monkeys 14 to 36 hours following laparoscopically timed ovulation. The reproductive tract was flushed 2, 4, or 24 hours later to recover ova. Four of five ova were recovered at 2 hours, one of five at 4 hours, and none of five at 24 hours after insertion. All ova recovered were in the oviduct. Since ova are normally found in the oviduct until 72 hours after ovulation, these results are interpreted to indicate acceleration and expulsion of ova from the tract following exposure to intravaginal Me PGF2 alpha in excess of 4 hours.
D000818:Animals; D002260:Carboprost / Q000008:administration & dosage* / Q000494:pharmacology; D003271:Contraceptive Agents, Female / Q000494:pharmacology; D005260:Female; D000882:Haplorhini; D008253:Macaca mulatta; D010066:Ovum Transport / Q000187:drug effects*; D011460:Prostaglandins F / Q000097:blood; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage*; D014590:Uterine Contraction / Q000187:drug effects; D014621:Vagina
D003271:Contraceptive Agents, Female; D011460:Prostaglandins F; D011461:Prostaglandins F, Synthetic; D002260:Carboprost