[New aspects of registration and drug influence of ureteral motility ].
A new method to determine ureteral motility by means of radioisotopes is presented. After administration of 99m-Tc-MDP or 99m-Tc-DTPA urine transport within the ureter is documented by functional way-time-matrices. The special resolution results of a series of 7 to 12 regions of interest covering the ureter out of which the information about its motility is extracted from a series of 300 to 480 single pictures. The time resolution is 1 to 2.5 seconds. The observation period varies between 5 and 20 minutes. Urine transport is outlined as an declined stripe in the matrix. Retroperistaltic waves or dyskinesies can also be detected with this method. 31 patients in whom radical surgery was performed for carcinoma of the cervix were examined by the described functional ureter test. The results show that changes in ureteral function like frequency or quality or even retroperistaltic contractions of the ureter can be observed by the urokinetogram, changes which can be traced neither by isotope renogram nor by intervenous pyelography. Similar observations could be made in 10 patients treated by radiotherapy. In 26 patients the influence of sympathico- and parasympathicomimetic agents on the ureteral motility was studied. The results show that an increase of contraction frequency can be obtained by alpha- and betamimetics and also by cholinesterase inhibitors. These results which are in consistance with the available literature will be analysed and discussed in detail. The urokinetogram opens new possibilities to get insights into the physiology of urine transport and is therefore of great interest as an addition to radiologic and urodynamic methods.
D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D005260:Female; D006801:Humans; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D010277:Parasympathomimetics / Q000494:pharmacology*; D011183:Postoperative Complications / Q000175:diagnosis; D011877:Radionuclide Imaging; D013566:Sympathomimetics / Q000494:pharmacology*; D014513:Ureter / Q000000981:diagnostic imaging / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D014563:Urodynamics; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy / Q000601:surgery
D002800:Cholinesterase Inhibitors; D010277:Parasympathomimetics; D013566:Sympathomimetics
Neue Erkenntnisse der Erfassung und medikamentösen Beeinflussung der Ureterenmotilität.