Effects of a nonpressor analogue of vasopressin on plasma renin activity and salt and water excretion in water-loaded, anesthetized dogs.
The object of this study was to determine the importance of vasoconstrictor activity in the suppression of renin secretion by vasopressin. Arginine vasopressin (AVP) (0.05 and 0.1 ng/kg/min) and a nonpressor analogue of vasopressin, 1-deamino-[4-threonine, 8-D-arginine]-vasopressin (dTDAVP) (0.01 and 0.05 ng/kg/min), were infused intravenously in anesthetized hypophysectomized dogs. Neither dTDAVP nor AVP influenced arterial pressure or heart rate but both suppressed plasma renin activity. Infusion of dTDAVP at 0.01 and 0.05 ng/kg/min suppressed plasma renin activity to 86 +/- 4% (p less than 0.05) and 63 +/- 6% (p less than 0.01) of the control values respectively. Infusion of AVP at 0.05 and 0.1 ng/kg/min suppressed plasma renin activity to 60 +/- 8% (p less than 0.01) and 59 +/- 12% (p less than 0.05) of the control values respectively. dTDAVP and AVP both produced significant increases in sodium excretion. These data demonstrate that vasoconstrictor activity is not required for the effects of vasopressin on renin secretion and sodium excretion.
D000758:Anesthesia; D000818:Animals; D001127:Arginine Vasopressin / Q000031:analogs & derivatives* / Q000494:pharmacology; D003894:Deamino Arginine Vasopressin / Q000031:analogs & derivatives* / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005260:Female; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D009994:Osmolar Concentration; D012083:Renin / Q000097:blood*; D012964:Sodium / Q000652:urine; D014556:Urine / Q000032:analysis; D014867:Water
D014867:Water; D001127:Arginine Vasopressin; C012865:vasopressin, deamino(4-Thr-8-Arg)-; D012964:Sodium; D012083:Renin; D003894:Deamino Arginine Vasopressin