Effects of acrylonitrile on rat liver cytochrome P-450, benzo(a)pyrene metabolism and serum hormone levels.
Intraperitoneal injections of acrylonitrile (AN), 33 mg/kg, into male rats daily for 3 consecutive days resulted in a 20% decrease in the liver microsomal content of cytochrome P-450. The in vitro formation of 9-hydroxy and 9,10-dihydrodiol metabolites of benzo(a)pyrene in liver microsomes was inhibited. Serum corticosterone levels were markedly decreased (30% of th values for control animals) demonstrating a disturbed pituitary-adrenal axis. A central effect of AN is supported by the finding that prolactin concentrations fell by approximately 60% in exposed animals. AN also induced a doubling FSH levels, whereas LH concentrations were the same as in the control animals. These results suggest an impaired spermatogenesis in the exposed animals.
D000181:Acrylonitrile / Q000633:toxicity*; D000818:Animals; D001580:Benzopyrenes / Q000378:metabolism*; D003345:Corticosterone / Q000097:blood; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006728:Hormones / Q000097:blood*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects; D009570:Nitriles / Q000633:toxicity*; D011388:Prolactin / Q000097:blood; D051381:Rats
D001580:Benzopyrenes; D006728:Hormones; D009570:Nitriles; D011388:Prolactin; D005640:Follicle Stimulating Hormone; D003577:Cytochrome P-450 Enzyme System; D000181:Acrylonitrile; D003345:Corticosterone