Relative efficacy of the topical use of amikacin, gentamicin and tobramycin in experimental Pseudomonas keratitis.
In a quantitative model of experimental Pseudomonas aeruginosa keratitis in guinea pigs, topical solutions of amikacin, gentamicin and tobramycin were equally effective. Solutions of 20 mg/ml were more effective than solutions of 3 mg/ml.
D000583:Amikacin / Q000627:therapeutic use; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005839:Gentamicins / Q000627:therapeutic use; D006168:Guinea Pigs; D007634:Keratitis / Q000188:drug therapy*; D011552:Pseudomonas Infections / Q000188:drug therapy*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D014031:Tobramycin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D000583:Amikacin; D014031:Tobramycin