[Effect of insulin therapy and hyperbaric oxygenation on the enzyme activity of tissue metabolism in diabetes mellitus].
In 120 patients with diabetes mellitus the indices of the blood and erythrocytic acid-alkali balance, glycemia level, blood lactate and pyruvate concentrations, the activity of serum malate dehydrogenase and lactate dehydrogenase, as well as of succinate dehydrogenase and alpha-glycerophosphate dehydrogenase in lymphocytic mitochondria were studied. A remarkable difference of the indices examined, depending on the disease severity, duration or compensation state of carbohydrate metabolism, was noted comparatively to those of normal. Insulin therapy and the diet No. 9, combined with hyperbaric oxygenation, was accompanied by a rapid (within 12 to 18 days) compensation of carbohydrate metabolism and good dynamics of all the tests. The results obtained are indicative of a significant improvement of the tissue metabolism both on the glycolysis level and in the cycle of tricarboxylic acids.
D000136:Acid-Base Equilibrium; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D002908:Chronic Disease; D003920:Diabetes Mellitus / Q000378:metabolism / Q000628:therapy*; D004734:Energy Metabolism; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation; D007328:Insulin / Q000627:therapeutic use*; D008214:Lymphocytes / Q000201:enzymology; D008297:Male
D001786:Blood Glucose; D007328:Insulin
Vliianie insulinoterapii i giperbaricheskoĭ oksigenatsii na aktivnost' riada fermentov tkanevogo obmena u bol'nykh sakharnym diabetom.