The plasma membrane and cellular handling of proteins.
The present study has shown that molecular conformation and charge determine how proteins are handled in the renal proximal tubule and the efficiency with which they are reabsorbed by the proximal tubule cells. Furthermore it is shown that in that in these cells there is a very extensive recycling of membranes directly from endocytic vacuoles and back to the luminal cell membrane.
D000818:Animals; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism* / Q000648:ultrastructure; D004705:Endocytosis; D005293:Ferritins / Q000378:metabolism; D005934:Glucagon / Q000378:metabolism; D007328:Insulin / Q000031:analogs & derivatives / Q000378:metabolism; D007687:Kidney Tubules, Proximal / Q000378:metabolism* / Q000648:ultrastructure; D008247:Lysosomes / Q000378:metabolism; D008854:Microscopy, Electron; D008871:Microvilli / Q000378:metabolism / Q000648:ultrastructure; D011506:Proteins / Q000378:metabolism*; D051381:Rats
D007328:Insulin; D011506:Proteins; C008147:insulin, iodo-; D005293:Ferritins; D005934:Glucagon