Monoamine oxidase inhibitors and histamine metabolism.
In rat, histamine metabolism is altered by some nonspecific inhibitors of monoamine oxidase (MAO) such as iproniazid, and, to a lesser extent, tranylcypromine. Type A MAO inhibitors, such as clorgyline and MD780515, do not seem to interfere with the metabolism of histamine. Deprenyl, a type B MAO inhibitor, shows some inhibition which is, however, much lower than that observed with iproniazid. The strong effect of iproniazid is probably due to its DAO inhibiting properties.
D000818:Animals; D003010:Clorgyline / Q000494:pharmacology; D006632:Histamine / Q000378:metabolism*; D007490:Iproniazid / Q000494:pharmacology; D008297:Male; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology; D023303:Oxazolidinones; D051381:Rats; D012642:Selegiline / Q000494:pharmacology; D014191:Tranylcypromine / Q000494:pharmacology
D008996:Monoamine Oxidase Inhibitors; D010080:Oxazoles; D023303:Oxazolidinones; D012642:Selegiline; D014191:Tranylcypromine; D006632:Histamine; D007490:Iproniazid; D003010:Clorgyline; C026234:cimoxatone