Treatment of carcinoma of the bladder by external irradiation - a clinical trial part III.
The results of a further prospective clinical trial for the treatment of carcinoma of the bladder are described. A standard four-field "brick" techinque, "whole bladder" volume was planned using 4 MeV external irradiation. The two dose regimens to be compared were: (i) 5700 rad in 19 treatments, 24 days overall, equivalent to that dose giving superior tumour control in the first trial, (ii) 4580 rad in 10 treatments, 11 days overall. These dosage schedules were theoretically equivalent as calculated from the Ellis NSD iso-effect formula. Seventy-four cases are available for preliminary review. The reactions during and immediately after therapy are noted. The incidence of tumour regression and control is compared and analysed in detail according to the influence of stage, histological type and macroscopic type.
D006801:Humans; D011446:Prospective Studies; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy; D012007:Rectum / Q000528:radiation effects; D001743:Urinary Bladder / Q000528:radiation effects; D001749:Urinary Bladder Neoplasms / Q000532:radiotherapy*