Antihypertensive (2-aminoethyl)thiourea derivatives. 2.
Starting with 2,6-dichlorophenyl isothiocyanate, 1-(2-aminoethyl)-2-cyano-3-(2,6-dichlorophenyl)guanidine (2) was prepared in three steps. In contrast to the corresponding thiourea 1, this compound was essentially inactive as an antihypertensive agent.
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D051381:Rats; D013890:Thiourea / Q000031:analogs & derivatives* / Q000494:pharmacology
D000959:Antihypertensive Agents; D013890:Thiourea