A comparative study of the effect of adriamycin on the sensitivity of mice to whole-body irradiation with 6-MVp photons or fast neutrons (67 MeV p--Be).
The effect of Adriamycin (doxorubicin hydrochloride) (10 mg/kg intraperitoneally) on the response of mouse gut to irradiation with 6-MVp photons or fast neutrons (67 MeV p--Be), was assessed with the six-day death endpoint. The drug reduced the LD50/6 by the same factor (approximately 1.25) for both types of radiation. Thus, the radiobiological effectiveness (RBE) (photons/neutrons) for gut damage is unaltered by the addition of Adriamycin. The data indicated no significant effect of drug scheduling if given within 16 hours before or after irradiation.
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D004317:Doxorubicin / Q000008:administration & dosage*; D004601:Elementary Particles; D005214:Fast Neutrons; D007422:Intestines / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D051379:Mice; D011882:Radiotherapy, High-Energy; D012062:Relative Biological Effectiveness
D000970:Antineoplastic Agents; D004317:Doxorubicin