Interactions of chlordiazepoxide and anorectic agents on rate and duration parameters of feeding in the rat.
d-Amphetamine (0.5 and 1.0 mg/kg) and dl-fenfluramine (2.0 and 4.0 mg/kg) reduced food intake in a short exposure feeding test, and their effects were counteraated by chloriazepoxide, particularly at 50 mg/kg. Chloriazepoxide reduced latency to eat, extended the durationof feeding and depressed the rate of feeding. Antagonism occurred in combination with d-amphetamine in relation to latency and duration, but in this experiment d-amphetamine did not affect feeding rate. Antagonism also occurred in combination with fenfluramine, with latency and duration measures, but only at the lower chlordiazepoxide dose. Instead, chlordiazepoxide (10.0 mg/kg) enhanced fenfluramine's effects to reduce feeding duration and feeding rate.
D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D002707:Chlordiazepoxide / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology; D004347:Drug Interactions; D005247:Feeding Behavior / Q000187:drug effects*; D005277:Fenfluramine / Q000494:pharmacology; D008297:Male; D051381:Rats; D013997:Time Factors
D001067:Appetite Depressants; D005277:Fenfluramine; D002707:Chlordiazepoxide; D003913:Dextroamphetamine