A clinical evaluation of Suprapen (amoxicillin plus flucloxacillin) in the management of childhood thoracic empyema.
Twenty-one children, all suffering from thoracic empyema, were treated with a combination of antibiotic therapy (Suprapen) and tube thoracostomy. A satisfactory clinical response with radiological and laboratory confirmation was seen in all but one patient, thus obviating the need for major surgery. Suprapen may be considered as a first line antibiotic in such cases of pleural sepsis in the absence of bacteriological confirmation of infection.
D000658:Amoxicillin / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003023:Cloxacillin / Q000031:analogs & derivatives*; D004338:Drug Combinations / Q000627:therapeutic use; D004653:Empyema / Q000188:drug therapy*; D005260:Female; D005436:Floxacillin / Q000627:therapeutic use*; D006801:Humans; D007223:Infant; D008297:Male; D013896:Thoracic Diseases / Q000188:drug therapy*
D004338:Drug Combinations; D005436:Floxacillin; C036075:Suprapen; D000658:Amoxicillin; D003023:Cloxacillin