The proliferative activity of antibody forming cells in the mouse bone marrow.
The proliferative activity of antibody-forming cells was studied in the bone marrow of mice immunized with either sheep erythrocytes (SRBC), TNP-LPS or DNP-Ficoll. Peak proliferative activity was found during the first few days of the response. Elimination of the proliferating cells in this period caused a profound and longlasting suppression of the antibody formation in the marrow.
D000818:Animals; D000921:Antibody-Producing Cells / Q000166:cytology / Q000276:immunology*; D000941:Antigens / Q000008:administration & dosage; D001853:Bone Marrow / Q000187:drug effects / Q000276:immunology; D001854:Bone Marrow Cells; D004136:Dinitrobenzenes / Q000276:immunology; D005260:Female; D005362:Ficoll / Q000276:immunology; D006462:Hemolytic Plaque Technique; D006918:Hydroxyurea / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000276:immunology; D008213:Lymphocyte Activation; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D012756:Sheep; D014301:Trinitrobenzenes / Q000276:immunology
D000941:Antigens; D004136:Dinitrobenzenes; D008070:Lipopolysaccharides; D014301:Trinitrobenzenes; D005362:Ficoll; D006918:Hydroxyurea