[Hypotensive anaesthesia in the oto-rhino-laryngological surgery using nitroglycerine (author's transl)].
Of 66 patients undergoing hypotensive anaesthesia for oto-rhino-laryngological surgery, a sufficient low-pressure state was obtained in only 72% of patients when nitroglycerine was used. The cumulative nitroglycerine-consumption varied between 4.0 and 98.6 mg (0.05-1.698 mg/kg body weight). In 40 cases a normal or weak nitroglycerine-effect was accentuated by dihydralazine and the extend and time course of the interaction were investigated. The exceedingly marked additional effect of this substance indicates a mutual potentiation of both drugs. The maximum of the dihydralazine-action appeared after 25-35 minutes. In 16 further cases dihydralazine was given intravenously before the nitroglycerine infusion as a premedication, whereby always constant and satisfactory hypotension could be produced. A disadvantage of these combinations, occurring in several cases, was the decreased manoeuvrability of hypotension. The continuation of the long-term sodium nitroprusside-hypotension by using nitroglycerine was succesful. Even after nitroglycerine application longer than 3 hours (up to 6 hours) the acid-base-status remained normal.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000293:Adolescent; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004078:Dihydralazine / Q000008:administration & dosage / Q000494:pharmacology*; D004357:Drug Synergism; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006830:Hydralazine / Q000031:analogs & derivatives*; D007023:Hypotension, Controlled / Q000379:methods*; D008875:Middle Aged; D005996:Nitroglycerin / Q000008:administration & dosage / Q000494:pharmacology*; D009599:Nitroprusside / Q000008:administration & dosage / Q000494:pharmacology; D010038:Otorhinolaryngologic Diseases / Q000601:surgery*
D009599:Nitroprusside; D006830:Hydralazine; D005996:Nitroglycerin; D004078:Dihydralazine
Intraoperative Hypotension mit Nitroglycerin in der HNO-Chirurgie.