[Mechanism of the harmful action of chelating agents on pancreatic islet cells].
Injection of chelants into the body induces the development of intravital zinc histochemical reaction in the pancreatic islet cells. The relationship was noted between this reaction intensity, duration of zinc chelate sojourn in the cells and the degree of cell injury. It is concluded that basic to the mechanism of alterative action of chelants on the insulocytes is the formation in them of toxic complexes with zinc.
D000818:Animals; D002614:Chelating Agents / Q000633:toxicity*; D006651:Histocytochemistry; D007515:Islets of Langerhans / Q000187:drug effects* / Q000378:metabolism; D011804:Quinolines / Q000633:toxicity; D011817:Rabbits; D013997:Time Factors; D015032:Zinc / Q000378:metabolism
D002614:Chelating Agents; D011804:Quinolines; D015032:Zinc
Mekhanizm povrezhdaiushchego deĭstviia khelantov na kletki pankreaticheskikh ostrovkov.