Error propagation in Escherichia coli and its relation to cellular ageing.
The mistranslation of alkaline phosphatase may not provide a definitive measure of errors in Escherichia coli protein synthesis. beta-Galactosidase which, unlike alkaline phosphatase, is an intracellular enzyme exhibits different mistranslation kinetics. Previous conclusions based on alkaline phosphatase data and showing no relation between error propagation and ageing may require re-evaluation.
D000469:Alkaline Phosphatase / Q000096:biosynthesis*; D002455:Cell Division; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics*; D005696:Galactosidases / Q000096:biosynthesis*; D007700:Kinetics; D014176:Protein Biosynthesis / Q000187:drug effects; D013307:Streptomycin / Q000494:pharmacology; D001616:beta-Galactosidase / Q000096:biosynthesis*
D000469:Alkaline Phosphatase; D005696:Galactosidases; D001616:beta-Galactosidase; D013307:Streptomycin