Effects of the bicyclic GABA agonist, THIP, on myoclonic and seizure responses in mice and baboons with reflex epilepsy.
THIP, 4,5,6,7-tetra hydroisoxazolo[5,4-C]pyridine-3-ol, has been evaluated as an anticonvulsant in DBA/2 mice showing audiogenic seizures, and in baboons, Papio papio, with photosensitive epilepsy. No protection against seizures was seen after THIP, 1-4 mg/kg, intraperitoneally in mice. THIP, 8 mg/kg, reduced clonic and subsequent seizure responses at 1 h. It also reduced rectal temperature and impaired posture and spontaneous activity. In baboons THIP, 0.25-8 mg/kg, iv, failed to protect against photically induced myoclonic responses. Toxic signs after THIP, 8 mg/kg, included focal or generalised myoclonus. THIP is thus not effective against reflex epilepsy.
D000818:Animals; D000927:Anticonvulsants; D004569:Electroencephalography; D000882:Haplorhini; D007555:Isoxazoles / Q000494:pharmacology*; D051379:Mice; D008811:Mice, Inbred DBA; D009207:Myoclonus / Q000503:physiopathology*; D010080:Oxazoles / Q000494:pharmacology*; D010215:Papio; D010775:Photic Stimulation; D012640:Seizures / Q000503:physiopathology*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D000927:Anticonvulsants; D007555:Isoxazoles; D010080:Oxazoles; D005680:gamma-Aminobutyric Acid; C015542:gaboxadol