The interrelationship between paraureteric diverticula, vesicoureteric reflux and duplication of the pelvicaliceal collecting system: a family study.
The incidence of a bifid pelvicaliceal system, vesicoureteric reflux, its sequelae and paraureteric diverticulum was determined in the patients and siblings of 22 patients with a paraureteric diverticulum. The results support the hypothesis that there is a direct genetic relationship between a paraureteric diverticulum, duplication of the pelvicaliceal system and vesicoureteric reflux. This suggests that the vesicoureteric reflux associated with a parauretic diverticulum is primary and related to lateral ectopia of the ureteric orifice. This syndrome complex may be inherited by multiple genes producing a cumulative effect, thus determining the length of the intravesical ureter, or by an autosomal dominant gene of variable penetrance.
D004240:Diverticulum / Q000150:complications / Q000235:genetics*; D005260:Female; D006801:Humans; D007670:Kidney Calices / Q000002:abnormalities; D007682:Kidney Pelvis / Q000002:abnormalities*; D008297:Male; D010375:Pedigree; D014513:Ureter / Q000002:abnormalities; D014515:Ureteral Diseases / Q000150:complications / Q000235:genetics*; D014718:Vesico-Ureteral Reflux / Q000209:etiology / Q000235:genetics*