[Biochemical and immunochemical characteristics of a new oral, chemical cholera bivalent vaccine and results of a trial of the preparation on volunteers].
Oral cholera vaccine contains 45% of O-antigen (serovars Ogawa and Inaba in equal parts) and at least 9 serologically active proteins; of these, toxoid (about 60% of the total amount of protein) and 5 enzymes have been identified: neuraminidase, proteinase, ribonuclease, phospholipase and ATPase. The safety, absence of reactogenicity and definite immunological effectiveness of the preparation in the primary immunization of volunteers have been shown.
D000907:Antibodies, Bacterial / Q000032:analysis; D000942:Antigens, Bacterial / Q000032:analysis; D001426:Bacterial Proteins / Q000032:analysis; D001428:Bacterial Vaccines / Q000009:adverse effects / Q000032:analysis / Q000276:immunology*; D002771:Cholera / Q000517:prevention & control*; D002986:Clinical Trials as Topic; D006801:Humans; D013607:Tablets; D013997:Time Factors; D014734:Vibrio cholerae / Q000276:immunology*
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D001428:Bacterial Vaccines; D013607:Tablets
Biokhimicheskaia i immunokhimicheskaia kharakteristika novoĭ oral'noĭ kholernoĭ knimicheskoĭ bivalentnoĭ vaktsiny i rezul'taty ispytaniia preparata na dobrovol'tsakh.