Effects of thyrotrophic-releasing hormone (TRH) on thermoregulation in the rat.
At ambient temperatures (Ta) of both 8 and 22 degrees C, intraventricular administration of TRH (10-80 microgram) produced a dose-dependent hypothermia in rats. The hypothermia was due to both decreased metabolic heat production and cutaneous vasodilatation. In contrast, at 30 degrees C Ta, TRH increased metabolic heat production (due to behavioral excitation) and led to hyperthermia.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D013696:Temperature; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*
D013973:Thyrotropin-Releasing Hormone