Chemical structure--acute toxicity relation of m-substituted derivatives N,N-dimethyl-4-aminoazobenzene with hepatocarcinogen effects.
The mol LD50 values were correlated with Hammett sigma constants in terms of the Hansen empiric equation 7 for meta substituted derivatives of N,N-dimethyl-4-aminoazobenzene. Good agreement and the line slope of the correlation was achieved. Relation acute toxicity--carcinogenity was discussed in the end.
D000818:Animals; D001711:Biotransformation; D007928:Lethal Dose 50; D008113:Liver Neoplasms / Q000139:chemically induced*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats; D013329:Structure-Activity Relationship; D004124:p-Dimethylaminoazobenzene / Q000378:metabolism / Q000633:toxicity*
D004124:p-Dimethylaminoazobenzene