[Value of polychemotherapy in the treatment of children with neuroblastoma].
The authors present a group of 10 children with neuroblastoma treated with multidrug chemotherapy. 5 children were treated according to VCAD protocol and 5 children according to COMP protocol. The VCAD protocol seems to be useful in less advanced stages of neuroblastoma (stage I and II after incomplete excision) as a prophylactic chemotherapy and in stage III with parallel irradiation of tumoral mass. Chemotherapy with COMP protocol can provoke palliation and prolongation of survival time, and sometimes significant remission. Having support of the treatment with adequate irradiation it is possible to restrict tumoral mass and consolidate the result od chemotherapy.
D000310:Adrenal Gland Neoplasms / Q000188:drug therapy*; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002648:Child; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008479:Mediastinal Neoplasms / Q000188:drug therapy*; D008727:Methotrexate / Q000008:administration & dosage; D009447:Neuroblastoma / Q000188:drug therapy*; D011239:Prednisolone / Q000008:administration & dosage; D012186:Retroperitoneal Neoplasms / Q000188:drug therapy*; D014750:Vincristine / Q000008:administration & dosage
D000970:Antineoplastic Agents; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone; D008727:Methotrexate
Ocena wielolekowej chemioteraph w leczeniu neuroblastoma u dzieci.