Histopathological modifications following immunotherapy with P 40 in rats bearing DMBA-induced mammary carcinoma.
Female Sprague-Dawley rats bearing primarily-induced mammary carcinomas were treated with a new immunostimulating agent (P 40). The histopathological modifications encountered in tumors, lymph nodes, liver and spleen are described. Intratumoral injections provoke a more widespread response of the RES, and particularly a more intense reaction in the draining lymph nodes, than systemic treatment.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D003352:Corynebacterium; D005260:Female; D007167:Immunotherapy; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D051381:Rats
D000276:Adjuvants, Immunologic; D015127:9,10-Dimethyl-1,2-benzanthracene