[Detoxification by the rat of compounds formed during thermal polymerization of linseed oil. II. Effects of discontinuous administration of the heated oil on the urinary excretion of glucuronides, liver weight and the tissue content of cyclic monomers].
During four successive periods of 9 days each, adult rats were fed alternatively fresh or hermopolymerized linseed oil in their diet. As compared to the control animals, the rats fed with the thermopolymerized oil showed increased urinary glucuronide excretion and higher liver weight, as well as a rise in the cyclic monomer content in that organ and, to a lesser degree, in the fat tissue. When fresh oil was substituted for heated oil in the diet, these animals recovered the levels of urinary glucuronides and liver monomers observed in the control rats. On the contrary, the rise in liver weight still observed can be considered as an indication of diet toxicity.
D000818:Animals; D005965:Glucuronates / Q000652:urine*; D006358:Hot Temperature; D008658:Inactivation, Metabolic; D008043:Linseed Oil / Q000008:administration & dosage / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors
D005965:Glucuronates; D008043:Linseed Oil
Détoxification par le rat des composés formés au cours de la thermopolymérisation de l'huile de lin. II.--Effets d'une administration discontinue d'huile chauffée sur l'excrétion urinaire de glucuronides, le poids du foie et les teneurs tissulaires en monomères cycliques.