[Pseudotumoral uterine reaction in the rat treated with a benzofuro-benzoxepin].
When orally administered, 5-(3-diméthylamino propyliden)-benzofuro [2,3-c] benzoxepin-1, which antagonizes several biogenic amines, is slightly sedative and has also endocrinological properties in the Rat, induces the appearance of localized lesions of uterine stroma in 2 to 16% of the animals. The cytological picture could suggest a tumorogenesis. In fact, these lesions represent a non-tumoral reactional hyperplasia with nuclear abnormalities due to a hormonal stimulation.
D000818:Animals; D001584:Benzoxepins / Q000494:pharmacology*; D002823:Chorion / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006965:Hyperplasia / Q000139:chemically induced; D051381:Rats; D014594:Uterine Neoplasms / Q000139:chemically induced*; D014599:Uterus / Q000187:drug effects* / Q000473:pathology
D001584:Benzoxepins; C027572:5-(3-dimethylamino propyliden)-benzofuro(2,3-c)benzoxepin-1
Réaction utérine pseudo-tumorale chez le rat soumis à l'action d'une benzofuro-benzoxepine.