Coagulation inhibitors.
A number of types of coagulation inhibitors can be seen in autoimmune states. These inhibitors can produce hypocoagulability by at least three mechanisms: by acting as a circulating anticoagulant; by the production of a functionally abnormal procoagulant; or, by the occurrence of an isolated reduction in the plasma level of a coagulation factor. The most common is the circulating anticoagulant which acts by either neutralizing a specific blood coagulation factor or by interfering in some fashion with coagulation factor interactions. The different types of coagulation inhibitors, their laboratory, and clinical manifestations are discussed.
D001327:Autoimmune Diseases / Q000097:blood* / Q000276:immunology; D001777:Blood Coagulation; D001779:Blood Coagulation Factors / Q000276:immunology; D005164:Factor IX / Q000037:antagonists & inhibitors; D005165:Factor V / Q000037:antagonists & inhibitors; D005169:Factor VIII / Q000037:antagonists & inhibitors; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000097:blood; D010314:Partial Thromboplastin Time
D001779:Blood Coagulation Factors; D005165:Factor V; D005169:Factor VIII; D005164:Factor IX