Evidence that type I diabetes and thyrogastric autoimmunity have different genetic determinants.
The prevalences of autoimmune endocrine disease and relevant organ-specific autoantibodies were determined in 141 patients with type I (insulin-dependent) diabetes and their families. All available members of the families were genotyped for HLA. Islet-cell antibody was found in 10 (4%) out of 248 unaffected siblings, all of whom were genetically potential cases of diabetes. One developed classical symptoms six months later. In contrast, thyroid and gastric parietal-cell antibodies occurred independent of the HLA-linked susceptibility to diabetes. These results suggest that different genes control the production of these autoantibodies and the susceptibility to type I diabetes.
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D003920:Diabetes Mellitus / Q000235:genetics / Q000276:immunology*; D005260:Female; D005802:Genes, MHC Class II; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007223:Infant; D007515:Islets of Langerhans / Q000276:immunology; D008297:Male; D013270:Stomach / Q000276:immunology*; D013961:Thyroid Gland / Q000276:immunology*
D001323:Autoantibodies; D006680:HLA Antigens