Indomethacin and gentamycin treatment in experimental kidney infection.
Experiences in experimental renal infection of rats treated with gentamycin, indomethacin, and by the combination of both drugs are reported. Urine osmolality of animals treated with combined therapy normalized after the first dose of indomethacin; their antibody titers against the pathogenic bacteria, as compared to the controls, decreased significantly. When drugs were administered separately the above immunologic changes could not be observed. Indomethacin did not inhibit the antibacterial effect of gentamycin and, administered alone, it increased the renal concentration ability.
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D004359:Drug Therapy, Combination; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use*; D007213:Indomethacin / Q000627:therapeutic use*; D007674:Kidney Diseases / Q000188:drug therapy* / Q000276:immunology / Q000473:pathology; D051381:Rats
D000907:Antibodies, Bacterial; D005839:Gentamicins; D007213:Indomethacin