Clinical efficacy of torasemide, a new diuretic agent, in patients with acute heart failure: a double blind comparison with furosemide.
Torasemide 60 mg and furosemide 120 mg were administered intravenously in a randomized double blind study in twelve patients with acute heart failure. The action of both drugs on urinary electrolyte and water excretion was very similar. The administration of torasemide but not of furosemide resulted in a significant reduction of systolic and diastolic blood pressure. No side effects occurred with either of the drugs in this elderly patient group.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004232:Diuretics / Q000627:therapeutic use*; D004311:Double-Blind Method; D004573:Electrolytes / Q000378:metabolism; D005260:Female; D005665:Furosemide / Q000627:therapeutic use*; D006333:Heart Failure / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013449:Sulfonamides / Q000494:pharmacology / Q000627:therapeutic use*; D000077786:Torsemide
D004232:Diuretics; D004573:Electrolytes; D013449:Sulfonamides; D005665:Furosemide; D000077786:Torsemide