Effect of protein cross-linking reagents on membrane currents of squid axon.
The effects of the protein cross-linking reagents glutaraldehyde, tannic acid, and formaldehyde were examined in voltage-clamped and internally perfused squid axons. All three reagents reduced sodium and potassium currents and reduced or abolished sodium inactivation. Glutaraldehyde and tannic acid produced an alteration of potassium current kinetics.
D000200:Action Potentials / Q000187:drug effects; D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D001369:Axons / Q000378:metabolism* / Q000502:physiology; D001693:Biological Transport, Active / Q000187:drug effects; D049832:Decapodiformes / Q000502:physiology; D005557:Formaldehyde / Q000494:pharmacology*; D005976:Glutaral / Q000494:pharmacology*; D047348:Hydrolyzable Tannins / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D011188:Potassium / Q000378:metabolism* / Q000502:physiology; D012964:Sodium / Q000378:metabolism* / Q000502:physiology; D013634:Tannins / Q000494:pharmacology*
D000447:Aldehydes; D047348:Hydrolyzable Tannins; D013634:Tannins; D005557:Formaldehyde; D012964:Sodium; D011188:Potassium; D005976:Glutaral