The burned hemophiliac.
Major surgical procedures are now performed with acceptable risk on patients with hemophilia A with pre- and postoperative anti-hemopilic Factor (AHF) infusions. However, there is almost no literature on care of the burned hemophiliac. We recently treated a patient with Factor VIII levels of less than 2% of normal and 45% TBSA burns. A forearm escharotomy was done with hemostatic protection by AHF infusion, but burn therapy, which included operative debridement and successful split-thickness skin grafting, was accomplished without the use of AHF. It is concluded that after early loading with cryoprecipitate, burned hemophiliacs do not require continued AHF, because repair and restoration of vascular integrity in small vessels may occur due to platelet plugging and vessel retraction. Tissue thromboplastin may also contribute to clotting in burned hemophiliacs.
D000328:Adult; D001777:Blood Coagulation; D002056:Burns / Q000150:complications / Q000601:surgery*; D003450:Cryoglobulins / Q000627:therapeutic use; D003646:Debridement; D005169:Factor VIII / Q000627:therapeutic use; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000503:physiopathology; D012306:Risk; D016038:Skin Transplantation; D013925:Thromboplastin / Q000502:physiology; D014182:Transplantation, Autologous
D003450:Cryoglobulins; D005169:Factor VIII; D013925:Thromboplastin