Prolonged cerebrospinal fluid acidosis in recently abstinent chronic alcoholics.
Significant cerebrospinal fluid (CSF) acidosis was evident in 80 chronic alcoholics (mean pH, 7.25 +/- 0.06) who were compared with 14 neurologic controls (mean pH, 7.31 +/- 0.02). Acidosis persisted for many weeks after the last drink, and there was no associated systemic acidosis. CSF pH correlated significantly with CSF anion gap, suggesting a primary cerebral metabolic abnormality. Even though one-quarter of the alcoholic patients had a CSF pH less than 7.21, mental impairment was less than expected for the degree of CSF acidosis noted.
D000138:Acidosis / Q000097:blood / Q000134:cerebrospinal fluid* / Q000209:etiology; D000328:Adult; D000368:Aged; D000437:Alcoholism / Q000097:blood / Q000134:cerebrospinal fluid* / Q000150:complications; D001639:Bicarbonates / Q000134:cerebrospinal fluid; D002245:Carbon Dioxide / Q000134:cerebrospinal fluid; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood / Q000134:cerebrospinal fluid; D011581:Psychological Tests
D001639:Bicarbonates; D002245:Carbon Dioxide; D010100:Oxygen