Hypothalamic amenorrhea in runners of normal body composition.
Three amenorrheic runners of normal body weight, in whom organic disease had been excluded, were found to exhibit: (1) normal body composition, (2) low baseline concentrations of serum LH and normal concentrations of FSH, (3) normal to hyper-responsiveness of LH and FSH to GnRH testing, and (4) normal and possibly increased frequency of LH pulsations. In one of the 3 runners, the administration of naloxone was followed by a pronounced increase in the amplitude of the LH pulsations.
D000293:Adolescent; D000328:Adult; D000568:Amenorrhea / Q000150:complications / Q000209:etiology*; D001823:Body Composition; D004700:Endocrine System Diseases / Q000150:complications; D004958:Estradiol / Q000097:blood; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007031:Hypothalamus; D007986:Luteinizing Hormone / Q000097:blood; D009270:Naloxone / Q000494:pharmacology; D010906:Pituitary Hormone-Releasing Hormones / Q000097:blood; D012420:Running; D013178:Sports Medicine
D010906:Pituitary Hormone-Releasing Hormones; D009270:Naloxone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone