A preliminary study of the mechanism of the hypoglycemic effect of polymeric prostaglandin PGBx in hereditary diabetic mice. Insulin response curves.
Polymeric prostaglandin PGBx normalizes the high blood sugar seen in hereditary diabetic mice. PGBx does not enhance the sensitivity of these mice to the hypoglycemic effect of insulin. It is therefore proposed that the hypoglycemic effect of PGBx may be an indirect consequence of induction of increased consumption by genetically defective mitochondria of two and three carbon fragments produced at the bottom of the glycolysis chain.
D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005260:Female; D007328:Insulin / Q000627:therapeutic use; D051379:Mice; D008817:Mice, Mutant Strains; D008928:Mitochondria / Q000187:drug effects; D011108:Polymers; D011453:Prostaglandins / Q000627:therapeutic use*; D011456:Prostaglandins B / Q000627:therapeutic use*
D007328:Insulin; D011108:Polymers; D011453:Prostaglandins; D011456:Prostaglandins B