Carprofen in osteoarthrosis.
Two randomized double-blind trials with carprofen in osteoarthrosis were performed. The first compared carprofen with ibuprofen in 2 groups of 10 patients for 8 weeks and the second compared carprofen administered in two different schedules (100 mg in the morning plus 200 mg in the evening versus 100 mg 3 times daily) for 4 weeks, also in 2 groups of 10 cases. The trials indicate that carprofen is effective and well tolerated. In the first trial efficacy shows a small trend in favour of carprofen and in the second a slight superiority of the b.i.d. schedule as compared to t.i.d.
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D011897:Random Allocation
D000893:Anti-Inflammatory Agents; D002227:Carbazoles; C007005:carprofen; D007052:Ibuprofen