Antibodies to native type I and II collagens detected by an enzyme linked immunosorbent assay (ELISA) in rheumatoid arthritis and systemic lupus erythematosus.
Anti-native type I and/or type II collagen antibodies measured by an immunoenzymatic immunosorbent assay were found to be present in 22.2% of the rheumatoid arthritis cases studied, 27.5% of systematic lupus erythematosus patients and 28.6% of patients with Overlap Syndrome. These antibodies were not associated with any particular clinical or radiological form of rheumatoid arthritis. Nevertheless, antibodies to native type I and/or type II collagens were associated with seropositive rheumatoid arthritis and antibodies to native type II collagen with rheumatoid arthritis which have antinuclear antibodies. In addition antibodies to native type I collagen were especially present in rheumatoid arthritis with extra-articular symptoms. Antibodies to native collagens disappear or are diminished after corticosteroid treatment. Unlike gold, D-penicillamine or non-steroid anti-inflammatory drugs have no effect on levels of antibodies to native type I and II collagens.
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000818:Animals; D000906:Antibodies / Q000032:analysis*; D000974:Antibodies, Antinuclear / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D002358:Cartilage, Articular; D002417:Cattle; D003094:Collagen / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D006801:Humans; D007124:Immunoenzyme Techniques; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D012867:Skin
D000305:Adrenal Cortex Hormones; D000906:Antibodies; D000974:Antibodies, Antinuclear; D003094:Collagen