Human cyclic neutropenia transferred by allogeneic bone marrow grafting.
Human cyclic neutropenia shows many features in common with the animal model of cyclic neutropenia in grey collie dogs. Until now, however, evidence was lacking that cyclic neutropenia in man as in the dog is caused by a defect in a transplantable hematopoietic stem cell. A patient is presented who, while undergoing bone marrow transplantation as treatment for acute lymphoblastic leukemia in relapse, acquired cyclic neutropenia from her histocompatible sibling donor.
D000380:Agranulocytosis / Q000209:etiology*; D000818:Animals; D016026:Bone Marrow Transplantation; D002675:Child, Preschool; D004285:Dogs; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications / Q000628:therapy; D009503:Neutropenia / Q000209:etiology* / Q000235:genetics; D010375:Pedigree; D010507:Periodicity; D014184:Transplantation, Homologous / Q000009:adverse effects*