[Demonstration of a factor produced by human lymphoid cell lines capable of increasing murine autologous rosette formation].
The xenogeneic mixed lymphocyte culture between murine splenocytes and mitomycin-treated human lymphoblastoid Daudi cells has been shown to result in a ten-fold increase of the autologous rosette forming cells (AFRC). The supernatant from Daudi cultures enhances the ARFC population to a similar extent, in addition it induces a mitogenesis comparable to that of Con A or LPS. However these two lectins do not modify the ARFC number. Thus Daudi supernatant acts specifically on a particular subset of lymphocytes. The mechanism of induction of the ARFC is discussed.
D000818:Animals; D002051:Burkitt Lymphoma; D002460:Cell Line; D006801:Humans; D008214:Lymphocytes / Q000276:immunology* / Q000378:metabolism; D051379:Mice; D008808:Mice, Inbred CBA; D012397:Rosette Formation; D013154:Spleen / Q000166:cytology; D013936:Thymidine / Q000378:metabolism
D013936:Thymidine
Mise en évidence d'un facteur produit par des cellules lymphoïdes humaines en lignée capable d'augmenter l'expression de rosettes autologues murines.