Non-mutagenicity of 2-methyl-2,3-epoxybutane and factors influencing the mutagenicity of 2,3-epoxybutane.
The compound 2,3-epoxybutane (2,3-EB) is a direct mutagen for the base-pair-substitution-sensitive strains TA 1530, TA 1535 and TA 100, in the absence and in the presence of metabolic activation by liver S9-mix. Under the same experimental conditions, the 2-methyl derivative of 2,3-EB was not mutagenic, up to 10 mg per plate. The parent compound (2,3-EB) was more active on strain TA 1530 in the presence of liver S9-mix. This was observed at every epoxide concentration tested. The increase of mutagenicity depended on the S9 concentration, the mix composition and to a small extent on the method utilized.
D000818:Animals; D001711:Biotransformation; D004852:Epoxy Compounds / Q000633:toxicity*; D004988:Ethers, Cyclic / Q000633:toxicity*; D008099:Liver / Q000378:metabolism; D008297:Male; D009153:Mutagens / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains; D012486:Salmonella typhimurium / Q000187:drug effects
D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D009153:Mutagens; C038843:2,3-epoxybutane