Stimulation of several functional properties of macrophages after injection of a suspension of killed Streptococci.
Mouse peritoneal macrophages elicited by injecting i.p. killed group C Streptococci were shown to exhibit several characteristics commonly found in inflammatory macrophages: they secreted high levels of plasminogen activator but had to be stimulated in vitro by LPS to elaborate significant amounts of lymphocyte activating factor (LAF); they contained increased acid hydrolase activities as compared to resident macrophages whereas ecto 5'-nucleotidase was diminished; and they released less arachidonic acid oxygenation products than resident macrophages. However, they also expressed biochemical and functional properties attributed to classically activated macrophages, harvested from immune animals: they displayed reduced levels of alkaline phosphodiesterase; when suitably triggered, they released large quantities of H2O2; and they were strongly cytostatic to syngeneic tumor cells.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D005260:Female; D006861:Hydrogen Peroxide / Q000378:metabolism; D007375:Interleukin-1 / Q000096:biosynthesis; D008264:Macrophages / Q000201:enzymology / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D010100:Oxygen / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism; D013291:Streptococcus
D001095:Arachidonic Acids; D007375:Interleukin-1; D006861:Hydrogen Peroxide; D010447:Peptide Hydrolases; D010100:Oxygen