Postoperative radiotherapy in rectosigmoid cancer Dukes' B and C: interim report from a randomized multicentre study.
The design, and complications seen during the first 2 years, of a randomized trial of postoperative radiotherapy for rectosigmoid cancer Dukes' B and C are presented and discussed. It is concluded that the present complication rate-below 10% in 221 patients-permits continuation of the intake, which is planned to include 550 patients, to demonstrate a possible increase in crude 5-year survival by 15% (60-75% in Dukes' B and 25-40% in Dukes' C), on the basis of a 0·01 significance level and a probability that the experiment will be successful of 0·90.
D002986:Clinical Trials as Topic; D006801:Humans; D009364:Neoplasm Recurrence, Local; D011183:Postoperative Complications; D011184:Postoperative Period; D011897:Random Allocation; D012004:Rectal Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D012811:Sigmoid Neoplasms / Q000401:mortality / Q000532:radiotherapy*