[Echocardiographic study of the effects of a nitroglycerin microcapsule preparation (author's transl)].
An echocardiographic study performed on 15 patients after administration of sublingual nitroglycerin showed a significant decrease in internal diameters of the left ventricle, associated with a moderate fall in blood pressure. A significant, but smaller decrease in diameters was also found 3 to 4 hours after oral administration of a nitroglycerin microcapsule preparation. The parameters measuring cardiac performance and the quality of myocardial contraction remained unchanged. The decrease in left ventricle internal diameters may be attributed to a reduction in pre-load and intraparietal ventricular tension. In addition, these results obtained by a non-invasive technique have confirmed the prolonged activity of nitroglycerin microcapsule preparations, previously demonstrated by hemodynamic and pharmacological experiments.
D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002214:Capsules; D004452:Echocardiography; D006321:Heart / Q000187:drug effects*; D006352:Heart Ventricles / Q000033:anatomy & histology / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D009060:Mouth Floor; D005996:Nitroglycerin / Q000008:administration & dosage* / Q000494:pharmacology
D002214:Capsules; D005996:Nitroglycerin
Etude échocardiographique des effets d'une trinitrine microencapsulée.