Teratology study in the mouse using a prostaglandin and a prostaglandin synthetase inhibitor.
Prostaglandin F2 alpha alone and in combination with sodium salicylate, was administered i.m. to pregnant CBA mice at various times on day 9 of gestation. A high frequency of rib malformations (90%) was recorded whereas the resorption rate was moderate (18%). When combining prostaglandin treatment (25 mg/kg i.m.) with sodium salicylate (500 mg/kg i.m.), the resorption rate increased. The malformation frequency remained unchanged except for the group with combined treatment at 10 a.m. (=maximum teratogenic period for salicylate induced rib malformations). This treatment resulted in a high frequency of maternal death; the resorption frequency was 75% and the surviving foetuses were malformed.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D016861:Cyclooxygenase Inhibitors; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D011247:Pregnancy; D011453:Prostaglandins / Q000633:toxicity*; D011460:Prostaglandins F / Q000633:toxicity; D012272:Ribs / Q000002:abnormalities; D012459:Salicylates / Q000633:toxicity*
D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins; D011460:Prostaglandins F; D012459:Salicylates