The synergistic effect of urine concentrate on 2-aminoanthracene in the Ames test.
Benzo[a]pyrene (B[a]P) and 2-aminoanthracene (2-AA) were tested in the Ames test in the presence of varying amounts of rat liver homogenate or in the presence of a concentrate of human urine. The results indicate that the synergistic effect found by Hannan et al. (Cancer Letters, 13 (1981) 203-212) of urine concentrate from smokers on the Ames test effect of 2-AA can be attributed to effects on the metabolic conversion of this compound and that this effect is not solely linked to smoking.
D000818:Animals; D000873:Anthracenes / Q000633:toxicity*; D002273:Carcinogens / Q000378:metabolism; D006801:Humans; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects; D012907:Smoking; D014556:Urine / Q000032:analysis*
D000873:Anthracenes; D002273:Carcinogens; C006593:2-anthramine