Enhanced chemotaxis to gentamicin-resistant strains of Pseudomonas aeruginosa.
The chemotactic response of human polymorphonuclear leukocytes (PMNLs) to gentamicin-sensitive and gentamicin-resistant strains of Pseudomonas aeruginosa was studied. Filtrates from the resistant strains markedly enhanced the chemotactic response of human PMNLs (leukotactic index [LI] = 40.4 micron), in contrast to the filtrates from the sensitive strains, which induced less migration of PMNLs (LI = 26.8 micron). This finding may explain previous observations that suggested that gentamicin-resistant strains of P. aeruginosa are less virulent than gentamicin-sensitive strains.
D002634:Chemotaxis, Leukocyte; D004352:Drug Resistance, Microbial; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D009504:Neutrophils / Q000276:immunology / Q000502:physiology*; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000276:immunology*
D005839:Gentamicins