Flurazepam effects on methylphenidate-induced stereotyped behavior.
The effects of flurazepam (0.0, 0.5, and 3.0 mg/kg) on methylphenidate-induced increases in stereotypy, gnawing, sniffing, and locomotion were evaluated in Swiss-Webster mice in daytime and nighttime experiments. Methylphenidate (50 mg/kg) increased overall stereotypy and stereotyped gnawing behavior; two doses of methylphenidate (25 mg/kg and 50 mg/kg) increased locomotion and sniffing behavior. Flurazepam 3.0 mg/kg augmented methylphenidate-induced stereotyped gnawing behavior and stereotypy. Flurazepam significantly decreased locomotion and sniffing, but did not interact with methylphenidate's effects on locomotion and sniffing.
D000818:Animals; D004357:Drug Synergism; D005479:Flurazepam / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D013239:Stereotyped Behavior / Q000187:drug effects*
D008774:Methylphenidate; D005479:Flurazepam