[Dantrolen solution of high active substance concentration. Preliminary communication (author's transl)].
The effectivity of treatment of a dramatically progressing malignant hyperthermia with Dantrolen depends, inter alia, on the easy production and applicability of the preparation. The modification described in this article, of an intravenously injectable Dantrolen solution which contains 10.0 mg active substance in 1.0 ml of a mixture of ethanol, glycerin and water, seems to meet these conditions, as established by experimental investigation.
D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D003620:Dantrolene / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D007263:Infusions, Parenteral; D008305:Malignant Hyperthermia / Q000188:drug therapy*; D013552:Swine
D002245:Carbon Dioxide; D003620:Dantrolene
Eine Dantrolenlösung mit hoher Wirkstoffkonzentration. (Vorläufige Mitteilung).