[Adenosine and its derivatives released by neocortex synaptosomes of the guinea pig].
Nerve endings (synaptosomes) prepared from guinea-pig neocortex were loaded with [14C] adenosine at 37 degrees C during a 30 min incubation. After the removal of the extracellular adenosine, the preparations were superfused and adenosine derivatives were analyzed in the superfusion fluid. The measurement of the amounts of [14C] nucleotides released in the presence or absence of metabolic inhibitor allowed us to conclude that adenosine and to a smaller extent inosine, are the molecules released from the synaptosomes during superfusion.
D000225:Adenine / Q000378:metabolism; D000227:Adenine Nucleotides / Q000378:metabolism; D000241:Adenosine / Q000031:analogs & derivatives* / Q000378:metabolism*; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D006168:Guinea Pigs; D007042:Hypoxanthines / Q000378:metabolism; D066298:In Vitro Techniques; D007288:Inosine / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism*
D000227:Adenine Nucleotides; D007042:Hypoxanthines; D007288:Inosine; D000225:Adenine; D000241:Adenosine
Adénosine et ses dérivés libérés par les synaptosomes du néocortex de Cobaye.