The stratum granulosum: a contractile system.
Sheets of stratum granulosum of glycerinated cow hoof epidermis showed immediate contraction on exposure to ATP in the presence of calcium. Other layers of the epidermis were unresponsive. Contraction of the stratum granulosum could be induced also by dopamine, but not by a variety of other pharmacological agents. It could be blocked by EGTA, lidocaine, or high concentrations of potassium. It is postulated that the keratohyalin granule is a contractile protein uniquely responsible for the changes observed.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002417:Cattle; D003285:Contractile Proteins / Q000502:physiology*; D004298:Dopamine / Q000494:pharmacology; D004533:Egtazic Acid / Q000494:pharmacology; D004817:Epidermis / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D008012:Lidocaine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology
D003285:Contractile Proteins; D004533:Egtazic Acid; D000255:Adenosine Triphosphate; D008012:Lidocaine; D011188:Potassium; D002118:Calcium; D004298:Dopamine