Dapsone-induced methemoglobinemia and hemolysis in the presence of familial hemoglobinopathy Hasharon and familial methemoglobin reductase deficiency.
Methemoglobinemia and hemolysis are well-known side effects after using high doses of dapsone (4,4'-diaminodiphenylsulfone). Their occurrence after low doses of the drug, and subsequent investigation, revealed the presence of hemoglobin Hasharon, and low content of NADH-dependent methemoglobin reductase in five members of an East European ashkenazic Jewish family.
D000328:Adult; D042966:Cytochrome-B(5) Reductase / Q000172:deficiency*; D003622:Dapsone / Q000009:adverse effects*; D006453:Hemoglobinopathies / Q000097:blood* / Q000201:enzymology; D006455:Hemoglobins, Abnormal; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced*; D009247:NADH, NADPH Oxidoreductases / Q000172:deficiency*
D006455:Hemoglobins, Abnormal; C029985:hemoglobin Sealy; D003622:Dapsone; D009247:NADH, NADPH Oxidoreductases; D042966:Cytochrome-B(5) Reductase