Progressive reduction in protein synthesis during involution and aging of the mouse thymus.
Total proteolytic activity and protein synthesis were measured in cell-free extracts of the thymus during its involution in 1-30-week-old C57Bl/6J mice, and in 10-, 12-, 14-, and 24-month-old adult mice of the same strain. The mean specific activity of the proteolytic enzymes exhibited no significant change during involution or throughout the mean life-span of the animals. In contrast, the rate of protein synthesis decreased rapidly during involution, and continued to decrease at a slower rate during aging of the mice.
D000135:Acid Phosphatase / Q000378:metabolism; D000375:Aging; D000818:Animals; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size; D010447:Peptide Hydrolases / Q000378:metabolism; D014176:Protein Biosynthesis; D013950:Thymus Gland / Q000033:anatomy & histology / Q000378:metabolism*
D000135:Acid Phosphatase; D010447:Peptide Hydrolases