Effect of intravenous adrenalin infusion and corticosteroid treatment in patients with von Willebrand's disease.
Intravenous adrenalin infusion (5 micrograms/kg, at most 160 micrograms in 10 min) normalized partial thromboplastin time (PTT) and ristocetin induced platelet aggregation (RIPA) in 4 of the 14 patients with von Willebrand's disease (VWD) in a short period of time. Although mean factor VIII (F-VIII) procoagulant activity was almost doubled 5 min following infusion, this was mainly observed in patients with relatively high baseline (> 2%) AHF activity. Mean F-VIII procoagulant activity rose by more than 100% following 10 days of corticosteroid treatment (deltacortil 2 mg/kg/day, at most 60 mg/day). PTT became normal in 6 of the 11 patients, but RIPA normalized only in 2. The improvement of RIPFA did not correspond to bleeding time in every patient. These results may suggest that if the baseline AHF activity is relatively high (greater than or equal to 9.5%), corticosteroid could be tried before schedule surgical intervention in patients with VWD.
D000293:Adolescent; D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D004837:Epinephrine / Q000627:therapeutic use*; D005169:Factor VIII / Q000378:metabolism; D005260:Female; D006801:Humans; D008297:Male; D010314:Partial Thromboplastin Time; D010974:Platelet Aggregation / Q000187:drug effects; D011241:Prednisone / Q000627:therapeutic use*; D014842:von Willebrand Diseases / Q000188:drug therapy* / Q000503:physiopathology
D005169:Factor VIII; D011241:Prednisone; D004837:Epinephrine