[Comparison of the effects of concanavalin A on cell growth and the transport of 3-O-methylglucose in chick embryo fibroblasts].
The proliferative capacity of Chick embryo fibroblasts was modified by Con A treatment. Con A decreased the growth of fibroblasts from young embryos (8 days), whereas the lectin stimulated the growth of fibroblasts from older embryos (16 days). This differential effect of Con A did not result from changes in cellular permeability to thymidine, but rather from Con A induced modifications of hexose transport. Changes in hexose transport would cause, as a response, parallel modifications in glycolysis and hence energy charge, which would alter proliferative capacity.
D019325:3-O-Methylglucose; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002642:Chick Embryo; D003208:Concanavalin A / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D007700:Kinetics; D037102:Lectins / Q000378:metabolism; D008757:Methylglucosides / Q000378:metabolism*; D008759:Methylglycosides / Q000378:metabolism*; D013997:Time Factors
D037102:Lectins; D008757:Methylglucosides; D008759:Methylglycosides; D003208:Concanavalin A; D019325:3-O-Methylglucose
Comparaison de l'effet de la Concanavaline A sur la croissance cellulaire et le transport de 3-O-méthylglucose dans les fibroblastes d'embryon de Poulet.