[Clinico-pharmacological trial of the preparation streptobicillin depot-syringae mammariae].
Streptobicillin depot-syringae mammariae contains: benzathin-penicillin--1,200,000 UI, streptomycin sulfa--1,000,000 UI, vitamin A oleosum--15,000 UI in a suitable base up to 10 ml. It is intended for the therapy and prophylaxis of inapparent mastitis of cows during the dry period. The preparation was tested in a total of 301 udder quarts of cows in terms of tolerance (general and local), depot effect, residual amounts, bactericidic effect, and therapeutic effect. The preparation was found to be well tolerated by the body and the parenchyma of the udder. The duration of its effect was 25 days. No residual amounts were found in the milk during the following lactation. The bactericidic effect in vitro reached 92.4 per cent, and in vivo--87.3 per cent of the cases. Positive therapeutic effect was found in 87.1 per cent of the cases, with subclinical mastitis it being 80.2 per cent, with latent infections--96.2 per cent, with secretion disturbances--94.3 per cent. Results revealed that the preparation was suitable to control inapparent mastitis in cows during the dry period.
D000818:Animals; D002417:Cattle; D002986:Clinical Trials as Topic / Q000662:veterinary; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations / Q000008:administration & dosage; D004361:Drug Tolerance; D005260:Female; D008414:Mastitis, Bovine / Q000188:drug therapy; D008826:Microbial Sensitivity Tests; D008892:Milk / Q000187:drug effects; D010401:Penicillin G Benzathine / Q000008:administration & dosage*; D013307:Streptomycin / Q000008:administration & dosage*; D014801:Vitamin A / Q000008:administration & dosage*
D004338:Drug Combinations; D014801:Vitamin A; C036566:streptobicillin depot; D010401:Penicillin G Benzathine; D013307:Streptomycin
Kliniko-farmakologichno izpitvane na preparata streptobicillin depot-syringae mammariae.