[Biomembrane permeability and lipid peroxidation upon exposure of the body to a shearing force].
Transversal overloading /3.5 and 6 un/ distinctly altered penetration of 14C-nicotinate and 35S-lipoate into cells and mitochondria. Increased secretion of proteins from cells, mitochondria and lysosomes was observed under these experimental conditions, especially in presence of Triton X-100 and in hypotonic media. Within the first 30 sec of overloading an increase in lipid peroxidation was found. Pretreatment with vitamin E decreased the effect of overloading on lipid peroxidation and on the membrane permeability.
D000818:Animals; D001921:Brain / Q000378:metabolism; D002463:Cell Membrane Permeability; D010856:Columbidae / Q000378:metabolism; D004910:Erythrocyte Membrane / Q000378:metabolism; D006112:Gravitation; D007425:Intracellular Membranes / Q000378:metabolism*; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism; D008247:Lysosomes / Q000201:enzymology; D051379:Mice; D008928:Mitochondria / Q000378:metabolism; D008930:Mitochondria, Liver / Q000378:metabolism; D009539:Nicotinic Acids / Q000378:metabolism; D010447:Peptide Hydrolases / Q000378:metabolism; D051381:Rats; D013045:Species Specificity; D008063:Thioctic Acid / Q000378:metabolism; D014810:Vitamin E / Q000494:pharmacology
D008054:Lipid Peroxides; D009539:Nicotinic Acids; D014810:Vitamin E; D008063:Thioctic Acid; D010447:Peptide Hydrolases
Pronitsaemost' biomembran i perekisnoe okislenie lipidov pri deĭstvii na organizm poperechnoĭ peregruzki.