Influence of dietary vitamin E on platelet thromboxane A2 and vascular prostacyclin I2 in rabbit.
Rabbits were maintained on vitamin E-deficient and vitamin E-supplemented diets. Thrombin- and collagen-induced thromboxane A2 production were significantly elevated in vitamin E-deficient platelets. Conversion of arachidonic acid to platelet thromboxane A2 was unchanged between the two groups of animals. Prostacyclin I2 production in the aortas from vitamin E-deficient rabbits was significantly elevated.
D015121:6-Ketoprostaglandin F1 alpha / Q000378:metabolism; D000818:Animals; D001013:Aorta, Thoracic / Q000378:metabolism; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D004032:Diet; D015232:Dinoprostone; D011464:Epoprostenol / Q000097:blood; D011458:Prostaglandins E / Q000097:blood; D011817:Rabbits; D013928:Thromboxane A2 / Q000097:blood*; D013931:Thromboxanes / Q000097:blood*; D014810:Vitamin E / Q000494:pharmacology*
D011458:Prostaglandins E; D013931:Thromboxanes; D014810:Vitamin E; D013928:Thromboxane A2; D015121:6-Ketoprostaglandin F1 alpha; D011464:Epoprostenol; D015232:Dinoprostone