Retreatment of recurrent nasopharyngeal carcinoma.
Thirty patients with recurrent primary nasopharyngeal carcinoma were reirradiated between 1949 and 1976. Twenty eventually demonstrated recurrence at or near the primary site, involving the nasopharynx in 4 and the central nervous system in 16. Long-term palliation was often achieved, and there were no severe complications except for one patient who died of necrosis of the base of the skull. The most frequent problems were hearing loss and trismus; necrosis of the nasopharynx was seen in only 2 patients. With therapy in the range of 18-25 MeV, significant palliation and an occasional cure can be achieved without excessive risk. Recurrent disease involving the skull may be controlled for several years using current techniques.
D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy / Q000556:secondary; D002493:Central Nervous System Diseases / Q000532:radiotherapy; D006311:Hearing Disorders / Q000209:etiology; D006801:Humans; D009303:Nasopharyngeal Neoplasms / Q000532:radiotherapy*; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy*; D011379:Prognosis; D011882:Radiotherapy, High-Energy / Q000009:adverse effects; D014313:Trismus / Q000209:etiology