Podophyllum toxicity: a report of a fatal case and a review of the literature.
A 59-yr-old male ingested 10 g of podophyllum in a fatal suicide attempt. Previously unreported nuclear and cytoplasmic changes were observed in circulating leukocytes. Symptoms did not occur until 10 h after ingestion with loss of reflexes, coma, and a marked lactic acidosis. Despite hemoperfusion, the patient expired 39 h after ingestion. The literature on podophyllum toxicity is reviewed.
D000293:Adolescent; D000328:Adult; D002675:Child, Preschool; D005260:Female; D006464:Hemoperfusion; D006801:Humans; D008297:Male; D008875:Middle Aged; D011033:Podophyllin / Q000378:metabolism / Q000506:poisoning*; D013405:Suicide
D011033:Podophyllin