Behavioral mutants of Drosophila melanogaster. III. Isolation and mapping of mutations by direct visual observations of behavioral phenotypes.
Sex-linked behavioral mutants were induced in Drosophila melanogaster with ethyl methanesulfonate (EMS) and isolated by direct visual observation of abnormal phenotypes. The four behavioral phenotypes used were flight-reduction, hyperactivity, hypoactivity and stress-sensitivity, and are easily discernable in either single or small populations of mutant flies. In one screen, forty-two behavioral mutants were recovered from strains derived from 800 mutagen-treated X chromosomes  In a second screen, 139 behavioral mutants were obtained from 2369 X chromosomes. The high rate at which behavioral mutants were recovered in the second screen, when compared to new visibles (28) and new temperature-sensitive lethals (124), suggests that the isolation of behavioral mutations on the autosomes of Drosophila and in the genomes of larger insects should be practical.
D000818:Animals; D001522:Behavior, Animal; D004331:Drosophila melanogaster / Q000235:genetics*; D005020:Ethyl Methanesulfonate / Q000494:pharmacology; D005260:Female; D005787:Gene Frequency; D005796:Genes; D008040:Genetic Linkage; D008297:Male; D009153:Mutagens; D009154:Mutation; D010641:Phenotype; D012730:Sex Chromosomes / Q000187:drug effects*; D014960:X Chromosome / Q000187:drug effects*
D009153:Mutagens; D005020:Ethyl Methanesulfonate