Effect of etidronate disodium on filterability of sickle cell erythrocytes.
The effect of etidronate disodium on the deformability of human sickle cell erythrocytes was determined. A filtration process that demonstrated changes in trapping of 51Cr-tagged sickle cells in the filtration apparatus was used to evaluate drug effects. Compared to the nontreated control, etidronate disodium [disodium dihydrogen (1-hydroxyethylidene)diphosphonate] reduced the trapping of sickled cells at low concentrations and increased trapping at high concentrations. These results indicate that etidronate disodium alters the deformability of sickled erythrocytes.
D000755:Anemia, Sickle Cell / Q000097:blood*; D003485:Cyanates / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000187:drug effects; D004913:Erythrocytes, Abnormal / Q000187:drug effects*; D012968:Etidronic Acid / Q000494:pharmacology*; D005374:Filtration; D006801:Humans; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology; D011453:Prostaglandins / Q000494:pharmacology
D003485:Cyanates; D011453:Prostaglandins; D007545:Isoproterenol; D012968:Etidronic Acid