[Effect of steroid hormones on the secretion of prostaglandins by human thymic epithelial cells in culture].
Increasing evidence suggests a role of prostaglandins in the immune response. As steroids have been shown recently to modulate prostaglandin secretion, we have studied the secretion of prostaglandin and the effect of various steroids in cultures of human thymus epithelial cells. Using thin layer chromatography and radioimmunoassays, we have shown that these cells produce substantial amounts of PGE2 and PGF2 alpha and that this secretion is modulated by steroid hormones. We therefore suggest that prostaglandin could represent one of the factors of the thymic environment involved in lymphocyte maturation, which respond to steroid hormones.
D002478:Cells, Cultured; D004847:Epithelial Cells; D004848:Epithelium / Q000378:metabolism; D006728:Hormones / Q000494:pharmacology*; D006801:Humans; D011453:Prostaglandins / Q000378:metabolism*; D011458:Prostaglandins E / Q000378:metabolism; D011460:Prostaglandins F / Q000378:metabolism; D013256:Steroids / Q000494:pharmacology*; D013950:Thymus Gland / Q000166:cytology / Q000378:metabolism*
D006728:Hormones; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D013256:Steroids
Effet des hormones stéroides sur la secrétion de prostaglandines par des cellules épithéliales thymiques humaines en culture.