The use of anesthetic drugs to reduce ICP changes in head-injured patients.
Chest physiotherapy causes increases in intracranial pressure (ICP) in patients with severe head injuries. In mechanically hyperventilated severe head injuries (PaCO2 3.3 - 4 kPa) 50% nitrous oxide in 50% oxygen exacerbated ICP increases associated with chest physiotherapy, while thiopentone and Althesin reduced these changes in ICP.
D000530:Alfaxalone Alfadolone Mixture / Q000627:therapeutic use*; D000777:Anesthetics / Q000627:therapeutic use; D002245:Carbon Dioxide; D006259:Craniocerebral Trauma / Q000188:drug therapy* / Q000628:therapy; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects*; D009609:Nitrous Oxide / Q000494:pharmacology; D010100:Oxygen / Q000494:pharmacology; D010313:Partial Pressure; D012121:Respiration, Artificial; D013874:Thiopental / Q000627:therapeutic use*
D000777:Anesthetics; D002245:Carbon Dioxide; D000530:Alfaxalone Alfadolone Mixture; D013874:Thiopental; D009609:Nitrous Oxide; D010100:Oxygen