The effect of premature and delayed birth on the development of UDP-glucuronosyltransferase activities towards bilirubin, morphine and testosterone in the rat.
In the rat, UDP-glucuronosyltransferase activities towards bilirubin, morphine and testosterone increase markedly after normal or premature birth. This rapid development is superimposed upon a much slower maturation of activity which occurs in utero during the last 2 days of normal gestation and gestation when birth is delayed. Development of all three activities is similar under these different conditions, suggesting a common developmenpal regulatory mechanism.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001663:Bilirubin / Q000494:pharmacology*; D005260:Female; D005865:Gestational Age; D014453:Glucuronosyltransferase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000196:embryology / Q000201:enzymology*; D009020:Morphine / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D013739:Testosterone / Q000494:pharmacology*
D013739:Testosterone; D009020:Morphine; D014453:Glucuronosyltransferase; D001663:Bilirubin