Lung cell reactions after inhalation of bacterial lipopolysaccharides.
Cells in airway lavage fluid were studied in guinea pigs exposed to an aerosol of bacterial lipopolysaccharide (LPS). The major response after a single exposure was a large increase in the number of macrophages and neutrophils. The neutrophil response decreased markedly after repeated exposure. De-complementation of the animals did not affect the response to a single exposure, nor did exposure to zymosan produce a neutrophil increase. It is suggested that other factors than serum complement activation initiate the neutrophil increase after LPS inhalation. One conceivable mechanism is the activation of pulmonary macrophages.
D000336:Aerosols; D000818:Animals; D004926:Escherichia coli; D005260:Female; D006168:Guinea Pigs; D007709:Klebsiella; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008168:Lung / Q000166:cytology / Q000187:drug effects*; D008297:Male; D013997:Time Factors; D015054:Zymosan / Q000494:pharmacology
D000336:Aerosols; D008070:Lipopolysaccharides; D015054:Zymosan