Allogeneic marrow transplantation for chronic granulocytic leukemia.
Six patients with Philadelphia-chromosome (Ph' +)-positive chronic granulocytic leukemia were transplanted from their HLA-identical siblings after conditioning with cyclophosphamide and 1'000 rad total body irradiation. All received cyclosporin-A for prophylaxis of Graft-versus-Host disease. All patients showed prompt engraftment and all are cytogenetically and clinically in complete remission. Two patients had transient mild signs of Graft-versus-Host-disease and one patient had unilateral facial nerve paresis of unknown origin. All are ambulatory and well 6-18 months (median 10 months) after transplantation.
D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation; D002904:Chromosomes, Human, 21-22 and Y; D003520:Cyclophosphamide / Q000627:therapeutic use; D003524:Cyclosporins / Q000627:therapeutic use; D005260:Female; D006087:Graft vs Host Reaction; D006680:HLA Antigens / Q000032:analysis; D006801:Humans; D007951:Leukemia, Myeloid / Q000628:therapy*; D008297:Male; D014184:Transplantation, Homologous; D014916:Whole-Body Irradiation
D003524:Cyclosporins; D006680:HLA Antigens; D003520:Cyclophosphamide