A mutant immunoglobulin light chain is formed by aberrant DNA- and RNA-splicing events.
A mutant immunoglobulin gene has been formed by an abnormal (non V/J) recombination event such that abnormal RNA splicing is required to form a mutant light chain. The structure of the gene suggests that the small palindrome thought to be involved in V/J joining also provides the basis for this abnormal DNA recombination and that the absence of a J segment and RNA splice signal allows an abnormal RNA splicing reaction to occur.
D000483:Alleles; D000818:Animals; D001483:Base Sequence; D004247:DNA / Q000235:genetics; D005796:Genes; D007127:Immunoglobulin Constant Regions / Q000235:genetics; D007147:Immunoglobulin Light Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics; D007145:Immunoglobulin kappa-Chains / Q000235:genetics*; D051379:Mice; D009194:Myeloma Proteins / Q000235:genetics*; D009694:Nucleic Acid Precursors / Q000235:genetics*; D012332:RNA, Heterogeneous Nuclear / Q000235:genetics; D011995:Recombination, Genetic; D014158:Transcription, Genetic
D007127:Immunoglobulin Constant Regions; D007147:Immunoglobulin Light Chains; D007135:Immunoglobulin Variable Region; D007145:Immunoglobulin kappa-Chains; D009194:Myeloma Proteins; D009694:Nucleic Acid Precursors; D012332:RNA, Heterogeneous Nuclear; D004247:DNA