Comparative studies on immunological properties of antitumor polysaccharide TC-13.
The biological and immunological characteristics of TC-13, an antitumor protein-bound polysaccharide, were studied. TC-13 had no direct cytocidal effect on Ehrlich carcinoma, but it induced antitumor resistance in mice whose tumors were regressed by TC-13. TC-13 changed the electrophoretic pattern of serum proteins of mice after its ip administration, causing a slow increase of the LB component and a rapid increase of the X component. TC-13 augmented the delayed-type hypersensitivity reaction to tumor homogenate, anti-SRBC antibody formation and the cytocidal activity of macrophages in an antibody-dependent system, but it had little or no effect on blast formation of spleen lymphocytes or carbon clearance. These results and comparative studies with other immunomodulators suggest that TC-13 is a unique polysaccharide having properties intermediate between those of lentinan, a simple-structured homologous polysaccharide from basidiomycetes, and lipopolysaccharide, a cell-surface component from bacteria.
D000818:Animals; D000900:Anti-Bacterial Agents; D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects; D000970:Antineoplastic Agents / Q000276:immunology*; D001797:Blood Protein Electrophoresis; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology; D002478:Cells, Cultured; D006020:Glycopeptides; D006023:Glycoproteins / Q000276:immunology / Q000494:pharmacology; D006462:Hemolytic Plaque Technique; D006968:Hypersensitivity, Delayed / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice; D011135:Polysaccharides, Bacterial / Q000276:immunology* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D006020:Glycopeptides; D006023:Glycoproteins; D011135:Polysaccharides, Bacterial; C035790:TC 13