[Surgical reduction of the kidney for inducing chronic kidney insufficiency].
By operative reduction of the renal tissue on 1/5 of both kidneys there are to be produced a chronic renal insufficiency in 21 black mini-pigs. The operative procedure was carried out at one time (nephrectomy and resection of the residual kidney) or at two times (in one group of it at first the nephrectomy and in the other group at first the resection of the kidney). Only 50% of the animals died with the symptom uremia in renal insufficiency. The nephrectomy--with a temporarily shifted resection of the residual kidney--effects the desired changes most approximately with very different reaction. This procedure appears as an animal model for the chronic renal insufficiency altogether not suitable.
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007668:Kidney / Q000601:surgery*; D007676:Kidney Failure, Chronic / Q000209:etiology*; D008297:Male; D009392:Nephrectomy; D013552:Swine; D013556:Swine, Miniature
Operative Nierenverkleinerung zur Erzeugung einer chronischen Niereninsuffizienz.