An improved method for the preparation of intermediate-purity antihemophilic factor concentrate for therapeutic usage.
An improved method involving pH changes in the process for the preparation of intermediate-purity antihemophilic concentrate offers several advantages over the standard method. Antihemophilic concentrates thus prepared are more soluble, more purified and more stable than the standard antihemophilic concentrates. High-potency antihemophilic concentrates with good solubility may be obtained by concentrating the [in-process] solution before lyophilization.
D005169:Factor VIII / Q000302:isolation & purification*; D005615:Freezing; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008722:Methods; D012586:Science
D005169:Factor VIII