External irradiation for malignant thyroid tumors.
Thirty-eight patients with residual or recurrent primary thyroid cancers which did not take up 1-131 were treated with external beam irradiation. Excluding 5 patients with malignant lymphoma, there were 23 patients with local disease and 10 with distant metastases. Doses ranged from 3,500 to 7,000 rads (35-70 Gy) among the 23 with local disease; local tumor control was achieved in 8. Six are alive and well 2-11 years later. External beam irradiation should be considered in locally advanced, incompletely resected, recurrent and metastatic thyroid malignancies of all histological types without 1-131 uptake. Reviewed are the age and sex distribution, histology, stage, extent of surgery, and dose and radiotherapy technique as they affect survival and patterns of failure.
D000230:Adenocarcinoma / Q000532:radiotherapy*; D000293:Adolescent; D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000532:radiotherapy / Q000556:secondary; D002277:Carcinoma / Q000532:radiotherapy*; D002291:Carcinoma, Papillary / Q000532:radiotherapy*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy / Q000556:secondary; D008297:Male; D008479:Mediastinal Neoplasms / Q000532:radiotherapy / Q000556:secondary; D008875:Middle Aged; D010315:Particle Accelerators; D011867:Radioisotope Teletherapy; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy; D013117:Spinal Cord Compression / Q000532:radiotherapy; D013964:Thyroid Neoplasms / Q000532:radiotherapy*
D003037:Cobalt Radioisotopes