Effects of repeated administration of potassium canrenoate (SC-14266) on serum gonadotrophin, prolactin, testosterone and progesterone in male rats.
Chronic administration of potassium canrenoate (SC-14266), a water-soluble anti-aldosterone agent, increased serum LH levels in male rats without altering serum levels of FSH, prolactin, testosterone and progesterone. The increase in serum LH may be due to the anti-androgenic effect of potassium canrenoate.
D000726:Androgen Antagonists; D000818:Animals; D002191:Canrenoic Acid / Q000494:pharmacology*; D005640:Follicle Stimulating Hormone / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D011245:Pregnadienes / Q000494:pharmacology*; D011374:Progesterone / Q000097:blood*; D011388:Prolactin / Q000097:blood*; D051381:Rats; D013148:Spironolactone / Q000494:pharmacology; D013739:Testosterone / Q000097:blood*
D000726:Androgen Antagonists; D006065:Gonadotropins, Pituitary; D011245:Pregnadienes; D013148:Spironolactone; D013739:Testosterone; D011374:Progesterone; D002191:Canrenoic Acid; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone