Human in vivo antigenic modulation induced by the anti-T cell OKT3 monoclonal antibody.
The anti-pan T cell monoclonal antibody OKT3 was administered daily for 2 weeks in four human renal allograft recipients. The antibody induced a dramatic and immediate depletion of peripheral T cells followed by an in vivo antigenic modulation of the OKT3-defined membrane antigen: after three injections, OKT3-treated patients showed a limited but significant number of OKT3- cells of T cell nature (as defined by OKT4 and OKT8) which recovered the OKT3 receptor after an overnight in vitro incubation in the absence of the monoclonal antibody.
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface / Q000032:analysis; D006801:Humans; D007108:Immune Tolerance; D007165:Immunosuppression Therapy; D007518:Isoantibodies; D016030:Kidney Transplantation; D007700:Kinetics; D008565:Membrane Proteins / Q000276:immunology / Q000378:metabolism; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface; D007518:Isoantibodies; D008565:Membrane Proteins