Effect of haemo- and peritoneal dialysis on the cell-mediated immune response in chronic uraemia.
Lymphocytopenia, decreased spontaneous rosette formation, and a decreased T lymphocyte count have been found in patients with non-uraemic glomerulonephritis (71 cases) and in different stages of uraemia (68 cases). In chronic glomerulonephritis and in the early stage of uraemia, cell-mediated hypersensitivity (lymphocyte migration inhibition) to glomerular basement membrane (GBM) characteristic of glomerulonephritis could be demonstrated. Hypersensitivity disappeared in the terminal stage of uraemia indicating endogenous immunosuppression.
D000328:Adult; D001485:Basement Membrane / Q000276:immunology; D002908:Chronic Disease; D005260:Female; D005921:Glomerulonephritis / Q000209:etiology / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D007165:Immunosuppression Therapy; D007958:Leukocyte Count; D007961:Leukocyte Migration-Inhibitory Factors / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008231:Lymphopenia / Q000150:complications / Q000276:immunology; D008297:Male; D010530:Peritoneal Dialysis / Q000009:adverse effects*; D006435:Renal Dialysis / Q000009:adverse effects*; D012397:Rosette Formation; D014511:Uremia / Q000209:etiology / Q000276:immunology*
D007961:Leukocyte Migration-Inhibitory Factors