Formation of GABA via oxidative deamination of putrescine in ovaries of immature rats after gonadotrophin stimulation.
The diamine oxidase catalyzed metabolism of 14C-putrescine was studied in the ovaries of immature rats with and without stimulation by gonadotrophin. This stimulation resulted in a statistically significant increase in the deamination rate of putrescine with a very predominant production of gamma-aminobutyric acid. No formation of polyamines was observed which indicated an importance of putrescine or of products of its oxidative deamination during this cellular activity.
D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D005260:Female; D006064:Gonadotropins, Equine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008996:Monoamine Oxidase Inhibitors / Q000494:pharmacology; D010053:Ovary / Q000201:enzymology*; D011700:Putrescine / Q000378:metabolism*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D006064:Gonadotropins, Equine; D008996:Monoamine Oxidase Inhibitors; D005680:gamma-Aminobutyric Acid; D006631:Amine Oxidase (Copper-Containing); D011700:Putrescine