[Alternative treatment with carmustine, vindesine and tamoxifen in previously cytostaticly (VAC, FMC) treated patients with metastatic breast cancer].
Looking for an alternative treatment for patients with advanced breast carcinoma resistant to the common treatment regimens, vindesine, carmustine (BCNU) and tamoxifen were used for further treatment. 27 patients were admitted to a two-step-treatment-schedule including a step I with tamoxifen alone and a step II with vindesine, carmustine and tamoxifen. Within the step I with tamoxifen 7 of 14 patients (50%) and within the consecutive step II with vindesine, carmustine and tamoxifen 4 of 20 patients (20%) responded to this regimen. The mean duration of the response was + 7.4 and + 9.0 months, respectively. The results suggest that effective palliation is still possible in some patients suffering from progressive disease after therapy with vincristine + adriamycin + cyclophosphamide and 5-fluorouracil + methotrexate + cyclophosphamide.
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy*; D002330:Carmustine / Q000008:administration & dosage / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D013629:Tamoxifen / Q000008:administration & dosage / Q000627:therapeutic use; D014747:Vinblastine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D014751:Vindesine
D000970:Antineoplastic Agents; D013629:Tamoxifen; D014747:Vinblastine; D014751:Vindesine; D002330:Carmustine
Alternativbehandlung mit Carmustin, Vindesin und Tamoxifen bei zytostatisch (VAC, FMC) ausbehandelten Patientinnen mit metastasiertem Mammakarzinom.