Effects of oxygen administration on the manifestation of acetate intolerance in dialysis patients.
In a prospective double-blind study. 12 patients were dialyzed four times each with nasal oxygen (O2) and 4 times each with air throughout acetate dialysis. Fewer symptoms (p less than 0.01), improved postdialysis task performance (p less than 0.04) and a tendency for less mean blood pressure drop (p less than 0.07 two-sided) were noted on O2 dialyses than on air dialyses. The rate of acetate metabolism was increased during O2 dialyses since serum acetate levels were significantly lower at 2, 3 and 4 h. Significant hypoxemia was demonstrated in 10 of these patients on acetate dialysis without O2. These results clearly demonstrate that: (1) prevention Of hypoxemia during dialysis reduces acetate intolerance, and (2) compromised tissue O2 availability may be partly responsible for dialysis morbidity.
D000085:Acetates / Q000009:adverse effects* / Q000378:metabolism; D000328:Adult; D000368:Aged; D001682:Biological Availability; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000139:chemically induced / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism; D010102:Oxygen Inhalation Therapy; D011446:Prospective Studies; D006435:Renal Dialysis / Q000009:adverse effects*
D000085:Acetates; D010100:Oxygen