Skeletal blood flow in Paget's disease of bone.
Using a modified plasma clearance technique, with 18F as a tracer, it is possible to measure blood flow to bone in man. In the normal adult skeleton, blood flow amounts to about 300 ml/min. In untreated Paget's disease of bone there is a striking increase, which is proportional to the biochemical severity of the disease : total blood flow to the skeleton is approximately doubled at an alkaline phosphatase of 50 KAu/dl (i.e. about four times the normal upper limit). Treatment with calcitonin brings a rapid return to normal, possibly before there is a detectable biochemical response. This may explain the rapid pain relief often reported on starting treatment with calcitonin.
D000328:Adult; D001842:Bone and Bones / Q000098:blood supply* / Q000000981:diagnostic imaging; D002116:Calcitonin / Q000627:therapeutic use; D002118:Calcium / Q000378:metabolism; D005461:Fluorine; D006801:Humans; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D010146:Pain / Q000188:drug therapy; D011868:Radioisotopes; D011877:Radionuclide Imaging; D012039:Regional Blood Flow
D011868:Radioisotopes; D005461:Fluorine; D002116:Calcitonin; D002118:Calcium