Antireproductive effects of a potent gonadotropin-releasing hormone antagonist in the male rat.
Administration of a potent antagonist of gondadotropin-releasing hormone (GnRH) antagonist [Ac-dehydro-Pro1, pCl-D-Phe2, D-Trp3,6]-N alpha-MeLeu7-GnRH to adult male rats for 2 weeks resulted in decreased testosterone production and sexual organ weights and in disrupted spermatogenesis. The results demonstrate the essential role of gonadotropin-releasing hormone in the maintenance of reproductive functions and have implications for the regulation of male fertility.
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D004347:Drug Interactions; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives*; D007248:Infertility, Male / Q000139:chemically induced*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009929:Organ Size; D010905:Pituitary Hormone Release Inhibiting Hormones / Q000494:pharmacology*; D010906:Pituitary Hormone-Releasing Hormones / Q000037:antagonists & inhibitors* / Q000502:physiology; D011467:Prostate / Q000187:drug effects; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects; D013737:Testis / Q000187:drug effects; D013739:Testosterone / Q000097:blood
D006063:Chorionic Gonadotropin; D010905:Pituitary Hormone Release Inhibiting Hormones; D010906:Pituitary Hormone-Releasing Hormones; D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; C026872:GnRH, (Ac-dehydro-Pro(1)-4-Cl-Phe(2)-Trp(3,6))-N-(alpha)-MeLeu(7)-; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone