Inhibitory and excitatory effects of dopamine on carotid chemoreceptors.
The effect of intravenous dopamine on carotid body chemoreceptor activity was investigated in 6 anesthetized cats which were paralyzed and artificially ventilated. Studies were performed at 4 steady-state PaO2 levels at a constant PaCO2 and at 4 levels of PaCO2 during hyperoxia. Dopamine inhibited carotid chemoreceptors before and excited them after haloperidol. Moderate stimulation of the receptors by hypoxia and hypercapnia augmented dopamine's effects. These results indicate that both inhibitory and excitatory dopamine receptors are present in the carotid body.
D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D002344:Carotid Body / Q000032:analysis / Q000187:drug effects*; D002415:Cats; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D006220:Haloperidol / Q000008:administration & dosage; D011954:Receptors, Dopamine / Q000032:analysis*
D011954:Receptors, Dopamine; D002245:Carbon Dioxide; D006220:Haloperidol; D004298:Dopamine