Plasma levels of chlorodesmethyldiazepam in humans.
Chlorodesmethyldiazepam (I) concentrations were followed for 72 h in the plasma of four volunteers given 2 mg of the drug orally. The drug appears to be well absorbed, reaching peak plasma levels of 20--30 ng ml-1 1--2 h after administration; 72 h after administration, plasma concentrations are still measurable (5 ng ml-1). The analytical method involved a single extraction of I from the plasma into benzene followed by centrifugation, evaporation, and gas-chromatographic analysis of the samples.
D000284:Administration, Oral; D000328:Adult; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001711:Biotransformation; D003975:Diazepam / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D003708:Nordazepam / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D003708:Nordazepam; C013434:chlordesmethyldiazepam; D003975:Diazepam