Attenuated response to insulin in very low birthweight infants.
Four hyperglycemia very low birthweight (VLBW) infants were given a constant infusion of insulin with parenteral alimentation in order to improve glucose tolerance. After an initial 45% decrease in serum glucose, intolerance recurred within hours to days despite delivery of as much as 16 units/kg/hour or regular insulin. Resulting serum insulin levels were as high as 72,000 microU/ml. It is suggested that insulin "resistance", instead of insulin deficiency, may be responsible for glucose intolerance in some infants.
D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D006943:Hyperglycemia / Q000188:drug therapy*; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy*; D007328:Insulin / Q000627:therapeutic use*; D010288:Parenteral Nutrition
D007328:Insulin; D005947:Glucose