Calcium and renin release: inhibition of low sodium-induced renin secretion by high calcium concentration in rat kidney perfusion.
The effects of changes in calcium on renin secretion have been studied in the isolated perfused rat kidney. Perfusion with free calcium buffer significantly decreases renin secretion as compared with control experiments (Ca++: 2.5 mM/l). Other calcium concentrations (1.25 mM/l) and 5 mM/l) do not affect basal renin secretion. When the renin release is previously increased by low sodium concentration (Na+: 110 mM/l) however, perfusion with high calcium buffer (Ca++: 5 mM/l) significantly inhibits this stimulation.
D000818:Animals; D002118:Calcium / Q000494:pharmacology / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D007606:Juxtaglomerular Apparatus / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D012083:Renin / Q000378:metabolism*; D012964:Sodium / Q000037:antagonists & inhibitors
D012964:Sodium; D012083:Renin; D002118:Calcium