[Characteristics of the effect of nitroglycerin on hemodynamics].
An examination was conducted of 45 healthy individuals 23 to 28 years of age who received nitroglycerine sublingually in a dose of 0.5 mg (15 persons) and by intravenous drip for one hour in doses of 3, 10, and 20 mg (groups of ten persons). It was shown that the drug had no essential effect on the rate of cardiac contractions and the diastolic arterial pressure. The systolic arterial pressure decreased with the increase of the nitroglycerine dose. The trend and the severity of changes in central hemodynamics were, in most cases, inversely dependent on the volume of cardiac ejection and did not depend on the dose and route of administration of the drug. With a cardiac index of 3 to 5.5 1/min/m2, this index in 71% of individuals reduced by 26% on the average. With an initial cardiac index of 2 to 2.9 1/min/m2, in 63% of individuals this index increased by 27% on the average. The authors distinguish three types of the reaction of hemodynamics to the administration of nitroglycerine: hypo-, hyper-,  and eucardiac.
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004341:Drug Evaluation; D004562:Electrocardiography; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D005996:Nitroglycerin / Q000627:therapeutic use*; D013997:Time Factors
D005996:Nitroglycerin
Nekotorye osobennosti vliianiia nitroglitserina na gemodinamiku.