Effect of polychlorinated biphenyl, dibenzofuran and dibenzo-p-dioxin on the susceptibility of male mice to endotoxin.
The effect of polychlorinated biphenyl (PCB), dibenzofuran (CDF) and dibenzo-p-dioxin (CDD) on endotoxin sensitivity was studied in male mice. The oral administration of CDF and CDD, once a week for 4 weeks, increased endotoxin sensitivity, whereas, PCB was not affective. On the other hand, residual levels of PCB were detected in thymus but CDF and CDD were not.
D000273:Adipose Tissue / Q000032:analysis; D000818:Animals; D001284:Atrophy; D001572:Benzofurans / Q000032:analysis / Q000633:toxicity*; D004147:Dioxins / Q000633:toxicity*; D004731:Endotoxins / Q000633:toxicity*; D007165:Immunosuppression Therapy; D008099:Liver / Q000032:analysis; D008297:Male; D051379:Mice; D009929:Organ Size; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000633:toxicity*; D000072317:Polychlorinated Dibenzodioxins / Q000032:analysis / Q000633:toxicity*; D013154:Spleen / Q000032:analysis; D013950:Thymus Gland / Q000032:analysis / Q000187:drug effects / Q000473:pathology
D001572:Benzofurans; D004147:Dioxins; D004731:Endotoxins; D000072317:Polychlorinated Dibenzodioxins; C023614:dibenzofuran; D011078:Polychlorinated Biphenyls