Neuropathic vesicourethral dysfunction in children. A trial comparing clean intermittent catheterisation with manual expression combined with drug treatment.
Forty-three children with overt neurological disease and neuropathic vesicourethral dysfunction were entered into a trial comparing clean intermittent catheterisation (CIC) with manual expression combined with drug treatment (non-CIC). The 22 children in the CIC group showed a significantly greater improvement in continence than the 21 children in the non-CIC group (P less than 0.001) without a significant increase in the incidence of urinary tract infections. Neither form of treatment is effective in reducing the risk of deterioration of renal function due to the combination of detrusor-sphincter dyssynergia and vesicoureteric reflux. Neither form of treatment improves continence in the presence of gross sphincter weakness or gross impairment of bladder compliance.
D001626:Bethanechol Compounds / Q000627:therapeutic use; D002648:Child; D002986:Clinical Trials as Topic; D004809:Ephedrine / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D010643:Phenoxybenzamine / Q000627:therapeutic use; D011413:Propantheline / Q000627:therapeutic use; D014522:Urethral Diseases / Q000188:drug therapy / Q000628:therapy*; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy / Q000628:therapy*; D014546:Urinary Catheterization; D014549:Urinary Incontinence / Q000628:therapy; D014718:Vesico-Ureteral Reflux / Q000628:therapy
D001626:Bethanechol Compounds; D010643:Phenoxybenzamine; D011413:Propantheline; D004809:Ephedrine