Islet transplantation in experimental diabetes of the rat. VII. Cryopreservation of rat and human islets. Preliminary results.
Islet transplantation in human diabetes at present is confronted with two major obstacles: isolation of a sufficient number of islets and islet graft rejection. "Tissue banking" would enable islet pooling from various donors and offers furthermore the advantage of in vitro manipulations in order to reduce islet immunogenicity. Recently we have reported successful cryopreservation and subsequent transplantation of porcine islets (Bretzel, Beule, Schäfer, Schneider, Pfeiffer and Federlin 1979). These preliminary data deal with cryopreservation and transplantation of isolated rat islets and cryopreservation of isolated human islets.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000628:therapy*; D005615:Freezing; D006029:Glycosuria; D006801:Humans; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000648:ultrastructure; D016381:Islets of Langerhans Transplantation; D051381:Rats; D014021:Tissue Preservation; D014184:Transplantation, Homologous
D001786:Blood Glucose; D007328:Insulin