Sulfated glycosaminoglycans of cultured fibroblasts from guinea-pig embryo kidney.
The sulfated glycosaminoglycan content of primary cultures of fibroblasts from guinea-pig embryo kidney is reported. A hybrid chondroitin sulfate comprises approx. 90% of these glycosaminoglycans from the cell coat. Changes in the proportion of labelled heparitin sulfate were also observed after successive subcultures. We postulate a possible correlation between the pattern of glycosaminoglycans and processes of cell selection and cell dedifferentiation in these cultures.
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D002462:Cell Membrane / Q000378:metabolism; D002478:Cells, Cultured; D002809:Chondroitin Sulfates / Q000378:metabolism; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000378:metabolism*; D006025:Glycosaminoglycans / Q000378:metabolism*; D006168:Guinea Pigs; D006497:Heparan Sulfate / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*
D002809:Chondroitin Sulfates; D006025:Glycosaminoglycans; D006497:Heparan Sulfate