Immunologic dysfunction in Sickle cell anaemia.
Selected cellular immune parameters were studied in 20 patients with sickle cell anaemia (SCA). A moderate absolute lymphocytes was observed in SCA patients compared with the control group. There was no significant difference between patients and controls in the mean E-rosette percentage and absolute number. PHA transformation was decreased in 50% of SCA patients, and some of them showed cutaneous anergy. It was suggested that imparied cell-mediated immunity is another factor to be included among defective SCA host-defense mechanism.
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008218:Lymphocytosis / Q000276:immunology; D008297:Male; D012397:Rosette Formation; D012882:Skin Tests