Opioid peptide identity and localization in hippocampus.
The hippocampus contains three times as much dynorphin-17 immunoreactivity (ir) as enkephalin-ir. Hippocampal mossy fibers exhibit weak enkephalin and strong dynorphin immunostaining. Intrahippocampal colchicine injections, which selectively destroy dentate granule cells, reduce enkephalin-ir and dynorphin-ir in mossy fibers. Intraventricular kainic acid, which causes degeneration of CA3-4 pyramidal cells, results in increased enkephalin immunostaining in mossy fibers. The enkephalin-ir cells and fibers of the entorhinal cortex which innervate the hippocampus and dentate gyrus do not contain dynorphin-ir.
D000818:Animals; D003429:Cross Reactions; D004723:Endorphins / Q000032:analysis*; D004745:Enkephalins / Q000032:analysis; D006624:Hippocampus / Q000032:analysis*; D006651:Histocytochemistry; D007158:Immunologic Techniques; D011863:Radioimmunoassay; D051381:Rats; D011919:Rats, Inbred Strains; D014018:Tissue Distribution
D004723:Endorphins; D004745:Enkephalins