Failure of mannitol to reduce electrocardiographic evidence of myocardial ischemia during upright exercise despite augmentation of cardiac output.
9 patients with clinically manifest ischemic heart disease underwent hemodynamic and electrocardiographic monitoring at rest, during several levels of submaximal and near maximal exercise on a treadmill and in recovery. The observations were repeated following infusion of mannitol. Despite augmentation of cardiac output at near maximal exercise, the electrocardiographic evidence of ischemia worsened.
D002302:Cardiac Output / Q000187:drug effects*; D003327:Coronary Disease / Q000503:physiopathology*; D004562:Electrocardiography; D005080:Exercise Test; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D008353:Mannitol / Q000494:pharmacology*; D008875:Middle Aged
D008353:Mannitol