Loperamide modifies Escherichia coli, heat-stable enterotoxin-induced intestinal secretion.
We have shown previously that loperamide, an opiate analogue, inhibits cholera-toxin- and prostaglandin E2-induced secretion in the rat small intestine. In these studies loperamide modified secretion induced by partially purified Escherichia coli, heat-stable enterotoxin in infant mice. The drug was effective whether administered before or after established secretion. These experiments provide further suggestive evidence that loperamide has a broad spectrum of antisecretory activity.
D000818:Animals; D002986:Clinical Trials as Topic; D004768:Enterotoxins / Q000037:antagonists & inhibitors*; D004926:Escherichia coli / Q000187:drug effects*; D006358:Hot Temperature; D007413:Intestinal Mucosa / Q000378:metabolism*; D008139:Loperamide / Q000494:pharmacology*; D051379:Mice; D010880:Piperidines / Q000494:pharmacology*; D011897:Random Allocation; D013997:Time Factors
D004768:Enterotoxins; D010880:Piperidines; D008139:Loperamide