Stimulation of resistance of immunocompromised mice by a muramyl dipeptide analog.
L18-MDP(Ala), a synthetic derivative of muramyl dipeptide, enhanced resistance against Escherichia coli and Candida albicans infections in aged mice and younger adult mice whose defense mechanism(s) had been depressed by X-ray irradiation or by treatment with cyclophosphamide.
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000375:Aging; D000818:Animals; D002177:Candidiasis / Q000276:immunology*; D004927:Escherichia coli Infections / Q000276:immunology*; D007113:Immunity, Innate; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice
D000276:Adjuvants, Immunologic; D000119:Acetylmuramyl-Alanyl-Isoglutamine; C035295:6-O-stearoyl-N-acetylmuramyl-alanylisoglutamine