Effects of Lilly 110140 (flouxetine) on self-stimulation behavior in the dorsal and ventral regions of the lateral hypothalamus in the mouse.
The effects of Lilly 110141 (fluoxetine) injected IP on self-stimulation behavior triggered in the dorsal and ventral regions of the lateral hypothalamus were studied in C57BL/6 mice strain. Lilly 110140 inhibits serotonin reuptake. It depresses dorsal self-stimulation at a low dose (5 mg/kg) and improves ventral sel-stimulation at a high dose (20 mg/kg). The changes brought about by the injection of the 5 mg/kg dose support the proposed inhibitory role of serotonin on self-stimulation and also suggest that the fibers communicating with certain serotonergic neurons are localized primarily in the dorsal region of the lateral hypothalamus.
D000818:Animals; D005473:Fluoxetine / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D011437:Propylamines / Q000494:pharmacology*; D012653:Self Stimulation / Q000187:drug effects*
D011437:Propylamines; D005473:Fluoxetine