Detrimental effect of endometrial biopsies on pregnancy rate following human menopausal gonadotropin/human chorionic gonadotropin-induced ovulation.
The effect of luteal phase endometrial biopsy was studied in 33 anovulatory women treated with human menopausal gonadotropins (hMG) to induce ovulation and pregnancy. Over-all, 33 of 85 ovulatory cycles resulted in pregnancy (39%). Of 50 nonbiopsied cycles, 26 resulted in pregnancy (52%) whereas only 7 of 35 biopsied cycles resulted in pregnancy (20() (P less than 0.01). Four pregnancies terminated in spontaneous first-trimester abortions, 12% in the nonbiopsied group and 14% in the biopsied group. Luteal phase endometrial biopsy significantly lowers pregnancy rates in hMG-induced ovulatory cycles, but does not change abortion rates.
D000022:Abortion, Spontaneous / Q000209:etiology; D001707:Biopsy, Needle / Q000009:adverse effects*; D001831:Body Temperature; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D004717:Endometrium / Q000601:surgery; D005260:Female; D006801:Humans; D008183:Luteal Phase; D008596:Menotropins / Q000494:pharmacology*; D010061:Ovulation Detection / Q000379:methods; D010062:Ovulation Induction / Q000379:methods; D011247:Pregnancy
D006063:Chorionic Gonadotropin; D008596:Menotropins