[Comparison of the bronchodilatatory efficacy of oral methylxanthines (author's transl)].
Two tablets of aminophylline (each 350 mg) or of a mixture (75 mg theophylline, 112,5 mg diprophylline, 112,5 mg proxyphylline per tablet) were given to 12 patients with reversible air-flow obstruction and their effects on lung function, blood pressure and pulse rate were surveyed for eight hours as an intra-individual randomized cross-over experiment. A three-day wash-out period was allowed between the studies on each patient. Statistical evaluation of the data shows that, on the average, the bronchodilator effects were comparable. Unwanted side-effects were seen in three patients after aminophylline. There were none after the mixture.
D000402:Airway Obstruction / Q000188:drug therapy; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004400:Dyphylline / Q000627:therapeutic use; D005029:Ethylenediamines / Q000627:therapeutic use*; D006801:Humans; D011674:Pulse / Q000187:drug effects; D013806:Theophylline / Q000627:therapeutic use*
D005029:Ethylenediamines; D004400:Dyphylline; D013806:Theophylline
Vergleich der bronchodilatatorischen Wirksamkeit oraler Methylxanthine.