Keloids and hypertrophic scars--immunological aspects.
A significant difference between keloids and hypertrophic scars could be demonstrated by means of acid elution technique of lymphoid blood cells and immunofluorescence studies. Tests on 20 patients with keloids revealed in the eluates antinuclear antibodies belonging to one or more of the 5 main classes and directed mainly against fibroblasts. On the other hand, there were no antinuclear antibodies detectable in the eluates of the 7 patients with hypertrophic scars and in 40 healthy controls.
D000293:Adolescent; D000328:Adult; D000974:Antibodies, Antinuclear / Q000302:isolation & purification*; D002648:Child; D002921:Cicatrix / Q000276:immunology*; D005347:Fibroblasts / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D007136:Immunoglobulins / Q000302:isolation & purification; D007627:Keloid / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D008875:Middle Aged; D012867:Skin / Q000276:immunology
D000974:Antibodies, Antinuclear; D007136:Immunoglobulins