Clinical comparison of alclometasone dipropionate and desonide ointments (0.05%) in the management of psoriasis.
This was a double-blind, randomized, parallel-groups comparison of alclometasone dipropionate and desonide ointments (0.05%) applied twice daily without occlusion for 3 weeks by patients with moderate to severe psoriasis. Data from thirty-three patients in each group showed that both treatments produced rapid amelioration of erythema, induration, and, especially, scaling; substantial improvement was evident after 1 week and continued thereafter. Differences between the groups were not statistically significant, but trends consistently favoured alclometasone. No adverse drug reaction occurred.
D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D003898:Desonide / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D009824:Ointments; D011246:Pregnadienetriols / Q000627:therapeutic use*; D011565:Psoriasis / Q000188:drug therapy*
D009824:Ointments; D011246:Pregnadienetriols; D003898:Desonide; C021137:alclometasone dipropionate; D008775:Methylprednisolone