Decreased LH response to the second of consecutive day luteinizing hormone releasing hormone (LHRH) in fusions among patients with constitutional delay of puberty: a phenomenon of pubertal maturation?
Consecutive day LHRH stimulation by continuous infusion has been used to evaluate pituitary reserve. Different responses on the 2 days were not present among non-pubertal hypopituitary patients, pubertal growth hormone deficient patients or adult males. However, patients with constitutionally delayed puberty demonstrated a greater serum LH response on day 1 than day 2. Urinary LH responses suggest a similar but not statistically significant pattern. This response may be a normal phenomenon of puberty or may represent part of the reason for constitutionally delayed puberty.
D000293:Adolescent; D003864:Depression, Chemical; D005640:Follicle Stimulating Hormone / Q000652:urine; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D013006:Growth Hormone / Q000172:deficiency; D006801:Humans; D007018:Hypopituitarism / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism* / Q000652:urine; D008297:Male; D010902:Pituitary Gland / Q000187:drug effects*; D011628:Puberty, Delayed / Q000097:blood* / Q000652:urine
D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone