[Effect of exogenous insulin on the proliferative activity of polypotent hematopoietic stem cells in mice].
The effect of insulin on the process of endogenous and exogenous spleen colony-formation in mice of Swiss strain was studied. In mice that received insulin the endogenous colony-formation was depressed for a short time, this process being glucose dependent. The number of spleen exogenous CFU decreased when the donors of bone marrow received insulin. A modulate influence of the hormone on the stem cell cycle has been shown.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D003114:Colony-Forming Units Assay; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D007328:Insulin / Q000494:pharmacology*; D051379:Mice; D008815:Mice, Inbred Strains
D007328:Insulin
Vliianie ékzogennogo insulina na proliferativnuiu aktivnost' polipotentnykh stvolovykh krovetvornykh kletok u mysheĭ.