Congenital combined factor VII and factor VIII deficiency.
This paper describes two family members who have a combined hereditary deficiency of factors VII and VIII. The propositus, a 16-year-old male, presented with recurrent gastrointestinal bleeding. He and his mother had moderate defects of factors VII and VIII. The propositus received factor VIII cover, during and after a laparatomy. The possible hereditary transmission pattern of the combined defect is discussed.
D000293:Adolescent; D000328:Adult; D004064:Digestive System / Q000503:physiopathology; D005168:Factor VII Deficiency / Q000150:complications* / Q000235:genetics / Q000503:physiopathology; D005260:Female; D006467:Hemophilia A / Q000150:complications* / Q000235:genetics / Q000503:physiopathology; D006801:Humans; D007813:Laparotomy; D008297:Male