[Are Crohn disease and ulcerative colitis the results of an immunoregulatory disturbance?].
The increasing knowledge regarding the regulation of immunological processes has stimulated different approaches to the analysis of chronic inflammatory bowel diseases. The well documented independence of the mucosa-associated immune system favours data obtained analysing immunological reactions within the mucosa. Thus lymphocytes and antibodies isolated from the mucosa are consequently used instead of those obtained from peripheral blood. Despite of an initiation by exogenic agents such as allergenic food constituents for microorganisms there is a growing body of evidence pointing to an immunoregulatory disturbance as underlying pathogenic mechanism for these diseases. This hypothesis is discussed regarding recent observations of a contrasuppressive circuit of regulatory lymphocytes in the murine intestine.
D000818:Animals; D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000276:immunology*; D003424:Crohn Disease / Q000209:etiology / Q000276:immunology*; D004927:Escherichia coli Infections / Q000150:complications; D005512:Food Hypersensitivity / Q000276:immunology; D006801:Humans; D007413:Intestinal Mucosa / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D010950:Plasma Cells / Q000276:immunology; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology; D014777:Virus Diseases / Q000150:complications
Sind Morbus Crohn und Colitis ulcerosa Folgen einer immunregulatorischen Störung?