[Prostacyclin synthesis in human umbilical vessels].
Umbilical arteries exhibit the highest capacity to synthesize PGI2 of all human blood vessels. This capacity is not only severely suppressed in adults, but also in umbilical arteries in mothers suffering from diseases accompanied by vessel wall alterations such as diabetes mellitus, hypertension and with smoking, for example. In parallel, severe morphological changes of endothelium and smooth muscle cells of umbilical arteries can be observed. It is assumed that a decrease in PGI2 formation might cause a disturbance in local haemodynamics.
D003920:Diabetes Mellitus / Q000378:metabolism; D011464:Epoprostenol / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000378:metabolism; D007231:Infant, Newborn; D011225:Pre-Eclampsia / Q000378:metabolism; D011247:Pregnancy; D011453:Prostaglandins / Q000096:biosynthesis*; D012306:Risk; D012907:Smoking; D014469:Umbilical Arteries / Q000378:metabolism*
D011453:Prostaglandins; D011464:Epoprostenol
Prostazyklinsynthese menschlicher Nabelschnurgefässe.