Metrazol produces conditioned taste aversion in rats.
Employing a two bottle drinking procedure where an animal's preference is measured between plain water and a novel fluid, it was found that the convulsant drug Metrazol produced a conditioned taste aversion to saccharin. This finding is contrary to that of previous reports and highlights the sensitivity of the two bottle method in detecting a taste aversion.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003216:Conditioning, Operant / Q000187:drug effects*; D004327:Drinking Behavior / Q000187:drug effects; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D012439:Saccharin / Q000494:pharmacology; D013649:Taste / Q000187:drug effects
D012439:Saccharin; D010433:Pentylenetetrazole