The effect of physical training in elderly subjects with special reference to energy-rich phosphagens and myoglobin in leg skeletal muscle.
Energy-rich phosphagens and myoglobin were determined in leg skeletal muscles of seven, 61- to 80-year-old, apparently healthy male subjects. The study repeated after the participants had been exercising on an ergometer bicycle twice weekly for 6 weeks. Before training, myoglobin and all intramuscular energy-rich phosphagens were within the range recorded for a larger series of subjects of similar age. When re-examined after training the myoglobin level remained the same but creatine decreased significantly and the ratio between phosphocreatine and total creatine increased. A slight but significant rise was also observed for the ATP/ADP ratio. It is concluded that age-related changes of intramuscular phosphagens in elderly subjects in part might be due to physical inactivity.
D000244:Adenosine Diphosphate / Q000032:analysis; D000255:Adenosine Triphosphate / Q000032:analysis; D000368:Aged; D000375:Aging; D001786:Blood Glucose / Q000032:analysis; D003401:Creatine / Q000032:analysis; D005080:Exercise Test; D006146:Guanidines / Q000032:analysis*; D006801:Humans; D007328:Insulin / Q000097:blood; D007866:Leg; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000032:analysis*; D009211:Myoglobin / Q000032:analysis; D010725:Phosphocreatine / Q000032:analysis; D010806:Physical Education and Training
D001786:Blood Glucose; D006146:Guanidines; D007328:Insulin; D009211:Myoglobin; D010725:Phosphocreatine; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D003401:Creatine