Solubility of carbon dioxide in lipid bilayer membranes and organic solvents.
Partition coefficients of carbon dioxide into lipid bilayers (liposomes) and organic solvents were measured as a function of temperature. The molar partition coefficient of CO2 into liposomes of egg lecithin at 25 degrees C was 0.95 (ml CO2/ml lipid)/(ml CO2/ml saline). The addition of an equimolar amount of cholesterol to the egg lecithin decreased the partition coefficient by about 25%. The partition coefficients for CO2 into liposomes at 25 degrees C were lower than the partition coefficients into octanol (1.3), hexadecane (1.5) and olive oil (1.7). The results are discussed in terms of the solubility-diffusion model of non-electrolyte transport through lipid bilayer membranes.
D002245:Carbon Dioxide; D002784:Cholesterol; D008051:Lipid Bilayers; D008081:Liposomes; D010539:Permeability; D010713:Phosphatidylcholines; D012995:Solubility; D012997:Solvents; D013696:Temperature
D008051:Lipid Bilayers; D008081:Liposomes; D010713:Phosphatidylcholines; D012997:Solvents; D002245:Carbon Dioxide; D002784:Cholesterol