Effect of ketanserin, a new inhibitor of 5-HT2 receptors, on plasma renin activity and aldosterone levels in normal subject.
The effect of intravenous administration (10 mg) of ketanserin, a pure, specific and selective blocking agent of 5-HT2 receptors (R 41 468: 3-[2-[4-(4-fluorobenzoyl)-1-piperidinyl]ethyl]-2,4(1H,3H)-quinazolinedione) on the renin-angiotensin-aldosterone system and blood pressure in 5 normal male volunteers was compared to the effect of saline alone. Ketanserin induced a small increase in plasma levels of both renin activity and aldosterone, which was not significantly different from that observed during control test. There was no significant effect on systolic and diastolic blood pressure. These preliminary data suggest that 5-HT2 receptors are probably not involved in the physiological control of basal renin secretion. However, further investigations are needed to elucidate the effects of ketanserin on the renin secretion and blood pressure.
D000328:Adult; D000450:Aldosterone / Q000097:blood*; D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D007650:Ketanserin; D008297:Male; D010880:Piperidines / Q000494:pharmacology*; D011985:Receptors, Serotonin / Q000187:drug effects*; D012083:Renin / Q000097:blood*
D010880:Piperidines; D011985:Receptors, Serotonin; D000450:Aldosterone; D007650:Ketanserin; D012083:Renin