Pancreatic tumors induced by a single intraperitoneal injection of azaserine in partial pancreatectomized rats.
Pancreatic tumorigenesis of azaserine by a single intraperitoneal (i.p.) injection after partial pancreatectomy in male Wistar rats was studied. Pancreatic lesions developed in all rats 52 weeks after the administration of azaserine at doses of 50 mg (Group 1) or 100 mg/kg body wt (Group 2). Histologically, there were hyperplastic nodules in 4 of 12 rats and 4 of 7 rats, in Groups 1 and 2, respectively, adenomas 100% in both groups, and adenocarcinomas 2 of 7 rats of Group 2. It appears that pancreatic regeneration induced by partial pancreatectomy enhances the azaserine tumorigenesis.
D015108:4-Hydroxyaminoquinoline-1-oxide / Q000633:toxicity; D000230:Adenocarcinoma / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D001377:Azaserine / Q000633:toxicity*; D002273:Carcinogens; D006965:Hyperplasia / Q000139:chemically induced; D007274:Injections, Intraperitoneal; D008297:Male; D010179:Pancreas / Q000473:pathology; D010180:Pancreatectomy; D010190:Pancreatic Neoplasms / Q000139:chemically induced*; D051381:Rats; D012038:Regeneration / Q000187:drug effects; D013997:Time Factors
D002273:Carcinogens; D015108:4-Hydroxyaminoquinoline-1-oxide; D001377:Azaserine