Comparison of the effects of two prostaglandin F2 alpha analogues-estrumate and lutalyse on the volume, activity, and proteolytic power of the abomasal juice in sheep.
The investigations were carried out on 7 wethers with cannulated fistulas of the "small" abomasum and rumen. In two series of experiments the optimal dose of one of the tested analogues of PGF 2 alpha (Estrumate 3-4 microgram/kg, Lutalyse 130-170 microgram/kg of body weight) was used. It was found the Estrumate in relation to Lutalyse caused a highly statistical significant rise (P less than 0.01) in the volume of secreted juice, free HCl, and total acidity in the same sheep. The specific activity (Anson mU/ml) increased more after Lutalyse (P less than 0.01) than after Estrumate injection. This analogue also caused significant (P less than 0.02) changes in the total activity (specific activity X juice volume of this sample). The obtained results expressed in per cent indicate that Estrumate exerts a greater effects on the parietal cells in the abomasal mucosa in sheep and Lutalyse stimulates more strongly the chief cells, as reflected in increased proteolytic power of the studied juice.
D000018:Abomasum / Q000187:drug effects / Q000378:metabolism*; D000818:Animals; D003008:Cloprostenol / Q000494:pharmacology*; D015237:Dinoprost / Q000031:analogs & derivatives*; D007700:Kinetics; D010447:Peptide Hydrolases / Q000378:metabolism; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*; D012756:Sheep; D013329:Structure-Activity Relationship
D011461:Prostaglandins F, Synthetic; D003008:Cloprostenol; D015237:Dinoprost; C010714:dinoprost tromethamine; D010447:Peptide Hydrolases