Non-steroidal anti-inflammatory drugs and blood pressure.
The effects of aspirin (1950 mg/day orally) or indomethacin (75 mg/day orally) on blood pressure were investigated in normotensive volunteers and hypertensive patients receiving antihypertensive medication. Aspirin (1950 mg/day) did not change blood pressure or body weight in normotensive or treated hypertensive subjects. No significant change in plasma renin concentration was seen with aspirin (1950 mg/day) in treated hypertensive subjects. Indomethacin (75 mg/day) significantly increased blood pressure in normotensive subjects and treated hypertensive subjects. Body weight increased significantly in the treated hypertensive subjects but not normotensive subjects. In treated hypertensive subjects indomethacin (75 mg/day) did not change plasma volume, but significantly decreased plasma renin concentration.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects*; D001795:Blood Pressure Determination; D001835:Body Weight; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007213:Indomethacin / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010953:Plasma Volume / Q000187:drug effects; D011187:Posture; D011897:Random Allocation; D012083:Renin / Q000097:blood
D000893:Anti-Inflammatory Agents; D012083:Renin; D001241:Aspirin; D007213:Indomethacin