[Epidemiology and clinical aspects of non-A, non-B hepatitis (author's transl)].
Among 288 patients with acute viral hepatitis investigated between 1970 and 1976 29 (10%) had non-A, non-B hepatitis. In 9 of these 29 patients posttransfusion hepatitis was proven, the remaining 20 patients had sporadic infections. The incubation period of posttransfusion hepatitis was 2--8 weeks in 7 patients and 12 and 16 weeks in the two other patients. Transaminases changed monophasically in 22 patients, bi- or multiphasic in 7. The disease took a subicteric course in a quarter of all cases. Out of the 29 patients 17 were followed up for 2 to 7 years, one or more recurrence occurred in 9 patients, usually within the first two years after onset of the disease. Five of these 9 patients had a biphasic rise of transaminases during the acute stage. The almost complete absence of autoantibodies in the course of the acute phase might be evidence of increased suppressor cell activity favouring a chronic course. Non-organ-specific autoantibodies were only rarely observed and were completely absent in patients with posttransfusion hepatitis.
D000208:Acute Disease; D000328:Adult; D001323:Autoantibodies / Q000032:analysis; D002908:Chronic Disease; D005260:Female; D005860:Germany, West; D006526:Hepatitis C / Q000201:enzymology / Q000453:epidemiology*; D006525:Hepatitis, Viral, Human / Q000453:epidemiology*; D006801:Humans; D008875:Middle Aged; D012008:Recurrence; D012189:Retrospective Studies; D013997:Time Factors; D065227:Transfusion Reaction
D001323:Autoantibodies
Epidemilogie und Klinik der Non-A-Non-B-Hepatitis. Eine retorspektive Studie aus den Jahren 1970--1976.