Platelet monoamine oxidase activity and plasma levels of non-catecholic phenylethylamines in insulin-dependent diabetic subjects.
The activity of blood platelets monoamine oxidase (MAO) was significantly reduced in a group of insulin-dependent diabetics when compared to sex- and age-matched controls. This enzymatic change was accompanied by a dramatic increase in the plasma levels of phenylethylamine, whereas no significant changes were observed for the concentration of either p-tyramine or phenylethanolamine. Levels of the o- and m-isomers of tyramine were below detectable limits (less than 0.050 ng/ml). A possible role of the MAO/monoamine system in the pathophysiology of diabetes is discussed.
D001792:Blood Platelets / Q000201:enzymology*; D003920:Diabetes Mellitus / Q000097:blood* / Q000188:drug therapy; D004983:Ethanolamines / Q000097:blood; D006801:Humans; D007328:Insulin / Q000627:therapeutic use*; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood*; D010627:Phenethylamines / Q000097:blood*; D014439:Tyramine / Q000097:blood
D004983:Ethanolamines; D007328:Insulin; D010627:Phenethylamines; C005332:N-phenylethanolamine; D008995:Monoamine Oxidase; D014439:Tyramine