Augmentin: laboratory studies.
Clavulanic acid is a beta-lactam antibiotic which, although it has little intrinsic activity, is a potent inhibitor of bacterial beta-lactamases. When combined with amoxycillin its range of activity includes penicillinase-producing strains of Staphylococcus aureus and many of the beta-lactamase-producing strains of Gram-negative bacilli. Bacteria sensitive to augmentin include amoxycillin-resistant strains of Haemophilus influenzae and Escherichia coli, in addition strains of Klebsiella aerogenes, Proteus mirabilis, Proteus vulgaris and Bacteroides fragilis are usually sensitive. The beta-lactamases produced by Enterobacter spp, Proteus morgani, Serratia marcescens and Pseudomonas aeruginosa are less susceptible to clavulanic acid and these bacteria are usually resistant to augmentin (1).
D000658:Amoxicillin / Q000494:pharmacology*; D019980:Amoxicillin-Potassium Clavulanate Combination; D000667:Ampicillin / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001424:Bacterial Infections / Q000382:microbiology; D004338:Drug Combinations / Q000494:pharmacology; D004926:Escherichia coli / Q000187:drug effects; D006801:Humans
D004338:Drug Combinations; D019980:Amoxicillin-Potassium Clavulanate Combination; D000667:Ampicillin; D000658:Amoxicillin