Feasibility of outpatient management after intra-articular yttrium-90: comparison of two regimens.
In a study comparing two regimens of treatment after intra-articular irradiation of the knee with yttrium-90 one group of patients was allocated to bed rest for 48 hours in hospital and the other to mobilisation at home. Initially a Robert-Jones orthopaedic bandage was applied to the knee in all patients, serving as a semi-rigid splint, but as loss of isotope from the knee was appreciable in the mobilised patients, subsequent patients were sent home with the knee in a plaster-of-Paris cylinder. No difference in extra-articular spread or chromosomal damage was found between the patients sent home with their knee in a rigid splint and those treated by bed rest. Clinical outcome at three months was satisfactory in all three groups. These results show that rigid splinting is essential in reducing extra-articular spread of the isotope but that bed rest is not necessary. Increases in intra-articular pressure associated with quadriceps muscle activity combined with flexion of the knee may be the most important factor affecting extra-articular spread of isotope.
D000553:Ambulatory Care; D001458:Bandages; D001510:Bed Rest; D002370:Casts, Surgical; D006801:Humans; D007270:Injections, Intra-Articular; D007719:Knee Joint / Q000378:metabolism; D008214:Lymphocytes / Q000528:radiation effects; D013585:Synovitis / Q000532:radiotherapy / Q000628:therapy*; D015021:Yttrium Radioisotopes / Q000008:administration & dosage / Q000378:metabolism / Q000627:therapeutic use*
D015021:Yttrium Radioisotopes