[Role of grafted Schwann cells in the regeneration of intraspinal nerve fibers when peripheral nerve, skeletal muscle or submandibular gland fragments are transplanted into the spinal cord of the mouse].
Small pieces of peripheral nerve, skeletal muscle or submandibular gland, taken from young or new-born mice, were grafted into the non-transected spinal cord of young albino mice, at the thoracic level, through a punctiform meningeal opening. Neighbouring intraspinal nerve fibres, severed during the grafting process, regenerate into and eventually throughout the transplants. In this regenerative process, sedentary or migrating Schwann cells of the transplants probably have a prominent influence in guiding the growth of the axonal sprouts they ensheathe and eventually myelinate.
D000818:Animals; D000831:Animals, Newborn; D051379:Mice; D009132:Muscles / Q000502:physiology / Q000637:transplantation*; D009416:Nerve Regeneration; D009474:Neurons / Q000502:physiology*; D010525:Peripheral Nerves / Q000502:physiology / Q000637:transplantation*; D012583:Schwann Cells / Q000502:physiology / Q000637:transplantation*; D013116:Spinal Cord / Q000502:physiology*; D013363:Submandibular Gland / Q000502:physiology / Q000637:transplantation*; D014184:Transplantation, Homologous
Influence des cellules de Schwann greffées sur la régénération des fibres nerveuses intraspinales lors de la transplantation de fragments de nerf périphérique, de muscle squelettique et de glande sous-maxillaire dans la moelle épinière de la souris.