Metabolism of 2-amino-3-phosphono[3-14C]propionic acid in cell-free preparations of Tetrahymena.
Incubation of 2-amino-3-phosphono[3-14C]propionic acid with cell-free preparations of Tetrahymena pyriformis resulted in incorporation of the radioactivity into phosphoenolpyruvate. No radioactivity was incorporated into phosphoenolpyruvate and 2-phosphonoacetate. Thus, the catabolic pathway of 2-amino-3-phosphonopropionic acid in Tetrahymena appears to be the same route as that found in rats through deamination to produce 3-phosphonopyruvate which is converted to 2-phosphonoacetaldehyde by decarboxylation, followed by both dephosphonylation and amination of the aldehyde to give acetaldehyde and 2-aminoethylphosphonic acid, respectively.
D000079:Acetaldehyde / Q000031:analogs & derivatives / Q000378:metabolism; D000409:Alanine / Q000031:analogs & derivatives* / Q000378:metabolism; D000615:Aminoethylphosphonic Acid / Q000378:metabolism; D000818:Animals; D002474:Cell-Free System; D009943:Organophosphorus Compounds / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism; D013769:Tetrahymena pyriformis / Q000378:metabolism*
C026220:3-phosphonopyruvate; D009943:Organophosphorus Compounds; D011773:Pyruvates; C000211:2-amino-3-phosphonopropionic acid; C003126:phosphonoacetaldehyde; D000615:Aminoethylphosphonic Acid; D000079:Acetaldehyde; D000409:Alanine