Inhibition of human platelet cyclooxygenase by alpha-tocopherol.
Alpha-tocopherol, an inhibitor of platelet aggregation, was evaluated for its effects on the synthesis of thromboxane and prostaglandins. A dose-dependent reduction in thromboxane B2 and prostaglandin D2 synthesis was observed with approximately 60% inhibition at 5.0 IU or alpha-tocopherol. Alpha-tocopherol produced a time-dependent, irreversible inhibition.
D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology*; D016861:Cyclooxygenase Inhibitors; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007700:Kinetics; D011451:Prostaglandin-Endoperoxide Synthases / Q000097:blood; D011457:Prostaglandins D / Q000096:biosynthesis; D013929:Thromboxane B2 / Q000096:biosynthesis; D014810:Vitamin E / Q000494:pharmacology*
D016861:Cyclooxygenase Inhibitors; D011457:Prostaglandins D; D014810:Vitamin E; D013929:Thromboxane B2; D011451:Prostaglandin-Endoperoxide Synthases