Trial of high-dose testosterone undecanoate in treatment of male infertility.
The effectiveness of high-dose testosterone undecanoate administered orally in suppressing spermatogenesis and eliciting the rebound-phenomenon was investigated in an uncontrolled clinical trial. Five men with fertility disturbances were treated for 10--12 weeks with 3 x 80 mg testosterone undecanoate daily. One patient achieved azoospermia and 2 oligospermia below 10 mill/ml, 1 suppressed to 27 mill/ml and 1 patient showed no effect. After cessation of treatment, 3 patients showed an increase in sperm concentration to greater than 50% of control values, one showed an increase of 35% and one showed a decrease in sperm count. The preliminary data suggest that although complete suppression of spermatogenesis is not uniformly achieved, a controlled study on the effects of high doses of testosterone undecanoate in male infertility may now by warranted.
D000328:Adult; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009845:Oligospermia / Q000139:chemically induced; D013073:Sperm Agglutination / Q000187:drug effects; D013076:Sperm Count; D013081:Sperm Motility; D013091:Spermatogenesis / Q000187:drug effects*; D013739:Testosterone / Q000097:blood / Q000494:pharmacology*
D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone