Furosemide chronopharmacology.
Twelve healthy males participated in a trial to determine whether furosemide diuresis and its effects on electrolyte excretion patterns, aldosterone concentrations and renin activity are subject to diurnal variations. Six treatments were give: placebo at 07h00, 13h00 and 19h00 and furosemide 40 mg at 07h00, 13h00 and 19h00. Each subject participated in six phases. It was found that the time of administration of furosemide does not affect the effect of the drug on sodium and potassium excretion and diuresis. There is a tendency for furosemide to elevate serum aldosterone levels and renin activity regardless of the time of administration.
D000328:Adult; D000450:Aldosterone / Q000097:blood; D002940:Circadian Rhythm; D002986:Clinical Trials as Topic; D005665:Furosemide / Q000494:pharmacology*; D006801:Humans; D008297:Male; D011188:Potassium / Q000652:urine; D012083:Renin / Q000097:blood; D012964:Sodium / Q000652:urine; D013997:Time Factors; D014556:Urine / Q000187:drug effects
D000450:Aldosterone; D005665:Furosemide; D012964:Sodium; D012083:Renin; D011188:Potassium