Immune complexes in Wuchereria bancrofti infection in man.
The levels of immune complexes in the sera of patients with Wuchereria bancrofti infection were determined by enzyme-linked immunosorbent assay, using a rabbit antibody to the adult Setaria digitata antigens SD2-4, and by the Clq-binding assay. Approximately 3-7% of microfilaraemic subjects and 30-40% of amicrofilaraemic symptomatic patients had levels of immune complexes that were significantly higher than the levels observed in non-filarial control subjects. The antigen in the polyethylene glycol-precipitated immune complexes was isolated. This W. bancrofti antigen was found to be similar to the S. digitata antigen SD2-4. Both antigens had the properties of an acidic glycoprotein of isoelectric point around pH 3.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000276:immunology / Q000302:isolation & purification*; D005368:Filariasis / Q000276:immunology*; D006801:Humans; D007158:Immunologic Techniques; D011817:Rabbits; D014957:Wuchereria / Q000276:immunology*; D014958:Wuchereria bancrofti / Q000276:immunology* / Q000302:isolation & purification
D000936:Antigen-Antibody Complex