[Effect of vitamin E and ubiquinone-9 on activity of ubiquinone-dependent enzymic systems of rat liver mitochondria].
It is shown that the activity of succinate- and NADH-ubiquinone-reductase systems as well as the ubiquinone content in the liver mitochondria of E-hypovitaminotic rats decrease as compared to their level in the liver mitochondria of healthy animals. Under conditions of E-hypovitaminosis alpha-tocopheronolactone and ubiquinone-9 3 h after intravenous injection to rats produce a pronounced normalizing effect on the ubiquinone content and on the activity of ubiquinone-dependent enzymic systems. It is assumed that a positive effect of vitamin E and its metabolite on the activity of these enzymic systems is to a considerable extent connected with an increase in the ubiquinone content in the rat liver mitochondria.
D000818:Animals; D042963:Electron Transport Complex II; D005260:Female; D007700:Kinetics; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology*; D016660:NAD(P)H Dehydrogenase (Quinone); D010088:Oxidoreductases / Q000378:metabolism; D011808:Quinone Reductases / Q000378:metabolism; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013386:Succinates / Q000378:metabolism; D014451:Ubiquinone / Q000378:metabolism*; D014810:Vitamin E / Q000494:pharmacology*; D014811:Vitamin E Deficiency / Q000201:enzymology*
D013386:Succinates; D014451:Ubiquinone; D014810:Vitamin E; D010088:Oxidoreductases; D042963:Electron Transport Complex II; D013385:Succinate Dehydrogenase; D016660:NAD(P)H Dehydrogenase (Quinone); D011808:Quinone Reductases
Deĭstvie vitamina E i ubikhinona-9 na aktivnost' ubikhinon-zavisimykh fermentnykh sistem mitokhondriĭ pecheni krys.