[Interstrain differences in the sensitivity of male sex cells to induction of dominant lethals by thiophosphamide].
Male mice of strains 101/HY, C57BL/6JY, CBA/LacY were injected intraperitoneally with 2.5 mg/kg dose of thioTEPA. The males were mated with tetrahybrid CBWA females during 5 weeks after the treatment. The same frequencies of dominant lethals were revealed in postmeiotic germ cells of the males of chosen strains. The strong influence of genotype on mutagenic effect in spermatocytes was found. The frequencies of dominant lethals in spermatocytes of 101, B6 and CBA males came to 42.7, 22.8 and 11.9% respectively. The differences in sensitivity of spermatocytes to dominant lethal induction correlated with variations in activity of genetic reparation in oocytes of these mouse strains females. The differences of translocations induced in spermatocytes were not found, that was due to low rate of these mutations (< 1%).
D000818:Animals; D005799:Genes, Dominant; D005804:Genes, Lethal; D005838:Genotype; D006824:Hybridization, Genetic; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D013045:Species Specificity; D013090:Spermatocytes / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*; D013852:Thiotepa / Q000633:toxicity*; D014178:Translocation, Genetic / Q000187:drug effects
D013852:Thiotepa
Mezhlineĭnye razlichiia v chuvstvitel'nosti muzhskikh polovykh kletok u mysheĭ k induktsii dominantnykh letaleĭ tiofosfamidom.