A new unified theory: C-C-2W is the chemical cause of all so-called cholesterol and cholestanol lipidoses.
The water-insoluble cholesterol-cholestanol-water adduct C-C-2W, chemical and physical cause of atherosclerosis and gallstones, has now been found in tendinous xanthoma as well; C-C-2W, and not cholestanol, is the initial compound deposited in hereditary CTX (cerebrotendinous xanthomatosis). From these and other findings it is theorized that what have been termed cholesterol or cholestanol lipidoses should instead be characterized as C-C-2W lipidoses. More than 1 mg of cholestanol . H2O present in the body causes crystallizaion of C-C-2W . This happens when the steroid meets cholesterol . H2O in sufficient concentration to reach a solubility product of 10(-7) mg/ml. In this light the literature can be interpreted to indicate that C-C-2W exerts negative effects on liver, intima tissue, eyes, lungs, and other parts of the body. Those effects include inflammation, cell necrosis, destruction of cell membranes, abnormal growth and, perhaps, neoplastic activity. Up to 200 g of C-C-2W in the body may be tolerated if evenly spread but not if localized in one or two areas only; e.g., the brain or the cardiovascular system. It is estimated that about 1000 g of C-C-2W, even if spread, are beyond the limit of human tolerance.
D004083:Cholestanol / Q000378:metabolism* / Q000494:pharmacology*; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000494:pharmacology*; D004338:Drug Combinations / Q000494:pharmacology; D006801:Humans; D008064:Lipidoses / Q000209:etiology*; D012995:Solubility; D014018:Tissue Distribution; D014973:Xanthomatosis / Q000378:metabolism*
D004338:Drug Combinations; C027453:cholesterol-cholestanol-water adduct; D004083:Cholestanol; D002784:Cholesterol