An in vitro study of lymphocyte migration in the presence of premalignant and malignant oral lesions.
The application of a continuous-time Markov chain theory to characterize and quantitate lymphocyte migratory pasths in the presence of premalignant and malignant oral lesions, has been presented. Early and premalignant lesions induce either a positive (towards the lesion), random or negative migration (away from the lesion) response in host lymphocytes. The lack of consistency most likely reflects the varying stages in host-tumor cell interaction during the early and variable phases in the tumor's natural history. Invasive cancers invariably induce a negative migration response in host lymphocytes. A possible mechanism and the implication of such a response on the efficacy of host-tumor interaction are discussed.
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000276:immunology / Q000473:pathology; D002278:Carcinoma in Situ / Q000276:immunology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000276:immunology / Q000473:pathology; D002465:Cell Movement; D005260:Female; D006801:Humans; D006965:Hyperplasia; D008214:Lymphocytes / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009055:Mouth / Q000473:pathology; D009062:Mouth Neoplasms / Q000276:immunology* / Q000473:pathology