Hallucinogenic agents as discriminative stimuli: a correlation with serotonin receptor affinities.
A choice between two levers in an operant chamber was used to train 24 rats, under a variable-interval 15 s schedule of sweetened milk reinforcement, to discriminate a hallucinogenic (psychotomimetic) agent, 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT), from saline administration. The 5-OMe DMT stimulus generalized in a dose-related manner to each of 14 tryptamine related analogs. With the exception of one compound, the effective dose for the 5-OMe DMT response correlated highly (r = -0.86) with 5-HT receptor affinity (as determined using an isolated rat fundus preparation).
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006213:Hallucinogens / Q000494:pharmacology*; D008732:Methoxydimethyltryptamines / Q000494:pharmacology; D011287:Prejudice / Q000187:drug effects*; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects*; D014363:Tryptamines / Q000494:pharmacology
D006213:Hallucinogens; D008732:Methoxydimethyltryptamines; D011985:Receptors, Serotonin; D014363:Tryptamines