Contralateral renal function following unilateral renal artery constriction.
The acute (0.5-3.0 h) response of the contralateral kidney to unilateral renal artery constriction was studied in 7 pentobarbital-anesthetized dogs. Within 30 min after unilateral renal artery constriction to a pressure of about 60 mm Hg, contralateral vascular resistance, sodium excretion and filtration fraction increased significantly while glomerular filtration rate, blood flow and plasma flow did not change. Renin secretion decreased dramatically within 30 min, demonstrating a negative venous minus arterial plasma renin activity in some dogs. Unilateral renal artery constriction did not change the rate of angiotensin II extraction across the contralateral kidney or the urinary renin activity (measured in 4 dogs). These results indicate that the acute response of the contralateral kidney to unilateral renal artery constriction is somewhat different from that seen in the chronic state.
D000804:Angiotensin II / Q000097:blood; D000818:Animals; D001158:Arteries; D001794:Blood Pressure; D003251:Constriction, Pathologic; D004285:Dogs; D005260:Female; D007668:Kidney / Q000503:physiopathology*; D008297:Male; D012077:Renal Artery; D012083:Renin / Q000097:blood / Q000378:metabolism; D014652:Vascular Diseases / Q000503:physiopathology*
D000804:Angiotensin II; D012083:Renin