Piroxicam, a structurally novel anti-inflammatory compound. Mode of prostaglandin synthesis inhibition.
Piroxicam is a potent inhibitor of prostaglandin biosynthesis. Experiments utilizing cell culture and microsomes derived from various sources have demonstrated that piroxicam is a selective inhibitor of the cyclooxygenase step of arachidonic acid metabolism. Little blocking activity is observed at the phospholipase, thromboxane or prostacyclin synthetase, and arachidonic acid lipoxygenase steps.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001095:Arachidonic Acids / Q000378:metabolism; D002460:Cell Line; D016861:Cyclooxygenase Inhibitors; D011464:Epoprostenol / Q000096:biosynthesis; D006801:Humans; D066298:In Vitro Techniques; D016859:Lipoxygenase Inhibitors; D051379:Mice; D008861:Microsomes / Q000378:metabolism; D010894:Piroxicam; D011453:Prostaglandins / Q000096:biosynthesis*; D011458:Prostaglandins E / Q000096:biosynthesis; D011460:Prostaglandins F / Q000096:biosynthesis; D011725:Pyridines / Q000494:pharmacology*; D013843:Thiazines / Q000494:pharmacology*; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors
D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D011725:Pyridines; D013843:Thiazines; D010894:Piroxicam; D011464:Epoprostenol; D013930:Thromboxane-A Synthase