Depletion of 9L rat brain tumor cell polyamine content by treatment with D,L-alpha-difluoromethylornithine inhibits proliferation and the G1 to S transition.
D000818:Animals; D001932:Brain Neoplasms; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D000518:Eflornithine; D007399:Interphase / Q000187:drug effects*; D009952:Ornithine / Q000031:analogs & derivatives* / Q000494:pharmacology; D011073:Polyamines / Q000378:metabolism*; D011700:Putrescine / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000378:metabolism
D011073:Polyamines; D013096:Spermine; D009952:Ornithine; D013095:Spermidine; D011700:Putrescine; D000518:Eflornithine