Cystine accumulation in cystinotic fibroblasts from free and protein-linked cystine but not cysteine.
The accumulation of cystine in cystinotic fibroblasts from free and protein-linked cystine has been investigated. Cystine is not accumulated from cysteine but is readily accumulated from cystine. The accumulation from free cystine does not occur as a result of pinocytosis or from the degradation of a rapidly metabolized protein pool. Further studies of the degradation of disulphide-containing proteins by these cells may aid understanding of the mechanisms of proteolysis.
D002460:Cell Line; D003545:Cysteine / Q000378:metabolism*; D003553:Cystine / Q000378:metabolism*; D003554:Cystinosis / Q000378:metabolism*; D005347:Fibroblasts / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007328:Insulin / Q000494:pharmacology; D008247:Lysosomes / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000494:pharmacology
D007328:Insulin; D011506:Proteins; D012710:Serum Albumin, Bovine; D003553:Cystine; D003545:Cysteine