Increase in the LHRH content of the organum vasculosum of the lamina terminalis and the medio-basal hypothalamus six hours after injection of kainic acid into the rat medial preoptic area.
The luteinizing hormone-releasing hormone (LHRH) content of the organum vasculosum of the lamina terminalis (OVLT) and that of the medio-basal hypothalamus (MBH) was studied 6 h after the injection of 1 microgram of kainic acid into the medial preoptic area (MPOA) at the day of diestrus. The injection resulted in a highly elevated LHRH content in the OVLT which exceeded that of the controls observed on the afternoon of proestrus. LHRH content in the MBH increased significantly, however, it did not reach the peak value of proestrus. No change occurred in luteinizing hormone (LH) and prolactin (PRL) levels, while serum follicle-stimulating hormone (FSH) values decreased significantly. The increased LHRH content of the OVLT and of the MBH might be due to an enhanced LHRH synthesis and/or to the stimulation of neurons which inhibit LHRH release.
D000818:Animals; D004971:Estrus / Q000187:drug effects; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects*; D007033:Hypothalamus, Middle / Q000187:drug effects*; D007608:Kainic Acid / Q000633:toxicity*; D009115:Muridae; D011247:Pregnancy; D011301:Preoptic Area / Q000187:drug effects*; D011759:Pyrrolidines / Q000633:toxicity*
D011759:Pyrrolidines; D007987:Gonadotropin-Releasing Hormone; D007608:Kainic Acid