Transient IgA-lambda paraproteinemia during treatment of acute myelomonoblastic leukemia.
Monoclonal plasma cell proliferation with secretion of IgA-lambda and free lambda light chains during a phase of bone marrow aplasia following intensive chemotherapy was observed in a patient suffering from acute myelomonoblastic leukemia. The clonal expansion and regression was investigated at the cellular level by immunofluorescence using an antiserum against the idiotype of the paraportein. Although a large panel of common antigens was used for testing, no antibody activity of the paraprotein could be demonstrated.
D000368:Aged; D000818:Animals; D002999:Clone Cells / Q000276:immunology; D003001:Cloning, Molecular; D005260:Female; D005455:Fluorescent Antibody Technique; D006168:Guinea Pigs; D006801:Humans; D007070:Immunoglobulin A; D007130:Immunoglobulin Idiotypes; D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains / Q000652:urine; D007948:Leukemia, Monocytic, Acute / Q000150:complications / Q000188:drug therapy*; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000188:drug therapy*; D010265:Paraproteinemias / Q000139:chemically induced*; D010950:Plasma Cells / Q000276:immunology
D007070:Immunoglobulin A; D007130:Immunoglobulin Idiotypes; D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains