[Grafts of human skin containing nevi or superficial nevocarcinoma onto athymic nu/nu mice: macroscopic and microscopic studies].
17 thin grafts of corpse skin containing neavi, were grafted onto the back of athymic mice. All the grafts took. The naevi were than deeply incised on 3 occasions. No evidence of abnormal healing, of pigment release, or of malignant transformation, appeared. 10 epidermal grafts of superficial malignant melanoma, taken from 4 different patients, took successfully. In 7 of these, superficial ulcerations appeared but were definitively re-epithelialised from the adjacent Mouse skin. 5 and 7 months later, the melanoma are stable, without local extensions, infiltration or apparent metastase. Despite the absence of an inflammatory reaction, these melanoma are paradoxically quiescent in nude Mice.
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D006085:Graft Survival; D006801:Humans; D008297:Male; D008545:Melanoma / Q000473:pathology*; D051379:Mice; D008819:Mice, Nude; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D009506:Nevus / Q000473:pathology*; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000473:pathology*; D012880:Skin Pigmentation; D016038:Skin Transplantation; D014183:Transplantation, Heterologous / Q000379:methods*
Greffes chez la Souis athymique nu/nu de peaux humaines porteuses de naevi ou de naevocarcinomes superficiels : étude macroscopique et microscopique.