[Sulfonamide-dependent growth of a strain of Escherichia coli K12 Thy- on Mueller-Hinton medium].
The Mueller Hinton medium does not allow the growth of Escherichia coli Thy- strains. This effect is due to the presence of uridine (or a derived compound) which interferes with the function of thymidine phosphorylase. The presence of sulphonamides, in some E. coli K12 Thy- mutants, overcomes this inhibition. The same phenomenon of rescue by sulphonamides has been reproduced in a minimal medium containing thymine and uridine. The biochemical and clinical implications of this observation are discussed.
D003470:Culture Media; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology / Q000254:growth & development*; D009154:Mutation; D013449:Sulfonamides / Q000494:pharmacology*; D013940:Thymidylate Synthase; D013941:Thymine / Q000378:metabolism; D014529:Uridine / Q000378:metabolism
D003470:Culture Media; D013449:Sulfonamides; D013940:Thymidylate Synthase; D013941:Thymine; D014529:Uridine
Croissance sulfamido-dépendante d'une souche d'Escherichia coli K12 Thy- sur milieu de Mueller-Hinton.