Acetaldehyde adducts of phospholipids.
Incubation of rat liver microsomes with acetaldehyde followed by reduction with borohydride of the Schiff bases formed leads to the formation of the N-ethyl derivatives of phosphatidylethanolamine and phosphatidylserine. Proof for this structure came from a comparison of these microsomal derivatives, and the nitrogenous bases derived therefrom by acid hydrolyses, with synthetic N-ethylphosphatidylethanolamine, N-ethylphosphatidylserine, N-ethylethanolamine, and N-ethylserine. Modification of membrane phospholipids by covalent binding of acetaldehyde to form Schiff bases may perturb some of the biochemical processes associated with membranes.
D000079:Acetaldehyde / Q000494:pharmacology*; D000818:Animals; D008862:Microsomes, Liver / Q000187:drug effects* / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000378:metabolism; D010718:Phosphatidylserines / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism*; D051381:Rats; D012545:Schiff Bases / Q000378:metabolism
D010714:Phosphatidylethanolamines; D010718:Phosphatidylserines; D010743:Phospholipids; D012545:Schiff Bases; D000079:Acetaldehyde