Mutagenicity of methylglyoxal in coffee.
Major carbonyl compounds from a extract of ground roasted coffee beans were identified as 5-hydroxymethylfurfural, acetol, glyoxal, methylglyoxal and diacetyl. Among these carbonyl compounds, methylglyoxal showed considerable mutagenic activity toward Salmonella typhimurium TA100 without S9 mix (around 100,000 revertants/mg). More than 50% of the total mutagenic activity of coffee can be accounted for by the activity of methylglyoxal.
D000447:Aldehydes / Q000633:toxicity*; D003069:Coffee / Q000032:analysis*; D009152:Mutagenicity Tests; D009153:Mutagens; D011765:Pyruvaldehyde / Q000302:isolation & purification / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects
D000447:Aldehydes; D003069:Coffee; D009153:Mutagens; D011765:Pyruvaldehyde