Promotion of benign hyperplastic lesions in hamster cheek pouch by membrane labilizing agents and calcium ion: evidence that intracellular calcium-induced release from growth control is an obligatory preliminary stage of tumor promotion.
Ca ion, ionophore 23187 and the membrane labilizing agents triton X-100, trypsin and phospholipase C promoted benign hyperplastic lesions (BHLs) but only rarely advanced tumors in hamster cheek pouch mucosa, which had been initiated with 7,12 dimethylbenz (a) anthracene. Retinyl acetate (RA) and croton oil markedly promoted both BHLs and advanced tumors. These results suggest that pathways modulated by intracellular Ca cause initiation-stabilized release from growth control, thus the promotion of BHLs, whereas additional mechanisms are required for the progression of BHLs to more advanced tumors. Some Ca-modulated systems which could be involved in promotion of BHLs are discussed in the light of published literature.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology; D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology*; D002610:Cheek / Q000473:pathology; D006224:Cricetinae; D005260:Female; D006965:Hyperplasia / Q000139:chemically induced*; D008566:Membranes / Q000187:drug effects*; D008647:Mesocricetus; D009369:Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism / Q000648:ultrastructure
D000001:Calcimycin; D015127:9,10-Dimethyl-1,2-benzanthracene; D002118:Calcium