[Synthesis of polyamine hydrochlorides and their oxidative deamination by diamine oxidase from rapidly growing tissues].
A simple, highly effective and economical method is developed for conversion of polyamines/putrescine, spermidine and spermine into their chlorhyndrates with a yield about 100%. The melting points of the preparations obtained and those available from "Serva" /FRG/ were identical; all the preparations were oxidized by diamine oxidase from rat liver tissue at the same rate. Tissues of transplanted hepatomas and malignant liver exhibited an absolute inability to oxidative deamination. The diamine oxidase activity in regenerating liver tissue was similar to the rate of deamination, estimated in liver tissue of sham-operated animals.
D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism*; D000818:Animals; D003641:Deamination; D004052:Diethylnitrosamine / Q000506:poisoning*; D006851:Hydrochloric Acid / Q000138:chemical synthesis / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D008115:Liver Regeneration; D051379:Mice; D009602:Nitrosamines / Q000506:poisoning*; D010084:Oxidation-Reduction; D011073:Polyamines / Q000138:chemical synthesis / Q000378:metabolism*; D011700:Putrescine / Q000378:metabolism; D051381:Rats; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000378:metabolism
D009602:Nitrosamines; D011073:Polyamines; D013096:Spermine; D004052:Diethylnitrosamine; D006631:Amine Oxidase (Copper-Containing); D006851:Hydrochloric Acid; D013095:Spermidine; D011700:Putrescine
Sintez khlorgidratov poliaminov i ikh okislitel'noe dezaminirovanie diaminoksidazoĭ iz bystrorastushchikh tkaneĭ.