Active and inactive renins in human urine.
Urinary excretions of active and inactive renin were studied in normal subjects and in patients with hypertensive or renal disease. Excessive excretion of active and inactive renins was observed in some patients with no significant correlation to their plasma levels or the degree of proteinuria. Inactive renin excretion correlated to active renin excretion, but the clearance was lower than that of the active form. No correlation was found between the urinary kallikrein excretion and the active/inactive renin ratio in the urine or the plasma. Urinary renin activity was increased by acidification and by trypsin treatment, but not by cold exposure. Both active and inactive renins in the urine showed multiple peaks corresponding to molecular weights between 45,000 and 64,000 by gel filtration.
D003080:Cold Temperature; D004789:Enzyme Activation; D004792:Enzyme Precursors / Q000652:urine*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008970:Molecular Weight; D011507:Proteinuria; D012083:Renin / Q000097:blood / Q000652:urine*; D014357:Trypsin / Q000494:pharmacology
D004792:Enzyme Precursors; D014357:Trypsin; D012083:Renin