Genotoxicity of flavoring agents.
The genotoxicity of 9 flavoring agents widely used in everyday foods was studied by a bacterial mutation test in the Salmonella/microsome system and by a chromosome test in Chinese hamster (CH) cells. In the mutation test none of the flavorings exhibited significant induction of his+ revertants in Salmonella typhimurium TA98 or TA100, either with or without rat-liver microsome as the metabolic activation system. On the other hand, in the chromosome test most of the agents induced severe chromosome aberration in the treated CH cells, suggesting a potential genotoxicity.
D000818:Animals; D001711:Biotransformation; D002460:Cell Line; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D005421:Flavoring Agents / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship
D005421:Flavoring Agents; D009153:Mutagens