Immunosuppressive drugs in the treatment of immunologic iridocyclitis in the rabbit.
The efficacy of the selected immunosuppressive drugs was studied on the model of iridocyclitis in the rabbit. Intensity of the inflammatory process was evaluated on the basis of biochemical parameters -- protein level and acute phase factors (seromucoid and sialic acid). All preparations used in the experiments indicated a decreasing exacerbation of inflammation as evaluated biochemically. Imuran showed the strongest effect while methotrexate, thiotepa and myleran were less effective.
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism; D001379:Azathioprine / Q000627:therapeutic use; D002066:Busulfan / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D006969:Hypersensitivity, Immediate / Q000188:drug therapy*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D009961:Orosomucoid / Q000378:metabolism; D011817:Rabbits; D012794:Sialic Acids / Q000378:metabolism; D013852:Thiotepa / Q000627:therapeutic use; D014606:Uveitis, Anterior / Q000188:drug therapy*
D007166:Immunosuppressive Agents; D009961:Orosomucoid; D012794:Sialic Acids; D013852:Thiotepa; D002066:Busulfan; D001379:Azathioprine; D008727:Methotrexate