[Plasmodium berghei: antibody response and protective immunity induced by vaccination].
The authors have studied the behaviour of Swiss mice and of 5 inbred strains of mice in order to investigate: the protective effect, in the homologous infection test, of six vaccine inoculations of irradiated parasites belonging to two strains of Plasmodium berghei: ISTISAN and K173; the capacity to produce humoral antibodies after vaccine treatments and during infection; the probable correlation between the high antibody titre and the protection against infection. The results of the present study show that the antibody response plays a precise role in the immunity induced by vaccination. There is a certain degree of correlation, which is more evident for K173 vaccine, between the level of antibody response during infection and the protective efficacy of vaccination.
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D000917:Antibody Formation; D005455:Fluorescent Antibody Technique; D008288:Malaria / Q000276:immunology / Q000517:prevention & control*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D010962:Plasmodium berghei / Q000276:immunology*; D014611:Vaccination; D014612:Vaccines
D000906:Antibodies; D014612:Vaccines
Plasmodium berghei: risposta anticorpale e immunità protettiva indotta da vaccinazioni.