[Fatty acid oxidation inhibitors--a new class of antidiabetic drugs. I. Experimental study of hypoglycemic effect of bromstearic acid in comparison with daonil].
Intraperitoneal injection of bromstearate inhibited the oxidation of fatty acids and glyconeogenesis and enhanced the glucose oxidation in intact animals and in rats with diabetes. Bromstearate induced marked hypoglycemia in intact animals, normalized hyperglycemia in rats with alloxan diabetes for 24 hours after the administration. In intact rats daonyl failed to influence fatty acid and glucose oxidation, but induced moderate hypoglycemia. In rats with alloxan diabetes daonyl inhibited oxidation of glucose and, to a lesser extent, of fatty acids, without any changes of hyperglycemia. Inhibitors of fatty acids oxidation are suggested for the pathogenetic therapy of diabetes.
D000496:Alloxan; D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D005905:Glyburide / Q000627:therapeutic use*; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D008297:Male; D009829:Oleic Acids / Q000378:metabolism*; D010084:Oxidation-Reduction / Q000187:drug effects; D013229:Stearic Acids / Q000627:therapeutic use*
D000975:Antioxidants; D007004:Hypoglycemic Agents; D009829:Oleic Acids; D013229:Stearic Acids; D000496:Alloxan; D005905:Glyburide
Ingibitory okisleniia zhirnykh kislot--novyĭ klass protivodiabeticheskikh sredstv. I. Eksperimental'noe issledovanie gipoglikemicheskogo deĭstviia bromstearinovoĭ kisloty v sravnenii s daonilom.