Aspirin absorption from a feeding jejunostomy.
In a 67-year-old man who had a feeding jejunostomy because of dysphagia paralytica, the absorption of aspirin was measured in terms of serum salicylate concentration. A 975-mg dose of aspirin was given as a slurry in water directly into the feeding tube. Peak serum levels of salicylate were well correlated with those in previous studies of aspirin absorption by the oral route in a geriatric population. However, unexpectedly, the half-life of the drug in this patient was twice as long (7.5 hours) as that found in six previous studies (3.7 hours) of elderly patients given similar doses.
D000368:Aged; D001241:Aspirin / Q000378:metabolism*; D004750:Enteral Nutrition; D006207:Half-Life; D006801:Humans; D007408:Intestinal Absorption; D007583:Jejunum / Q000378:metabolism*; D008297:Male; D012459:Salicylates / Q000097:blood
D012459:Salicylates; D001241:Aspirin