The analgesic effect of intravenous indoprofen and lysine acetylsalicylate in patients with postoperative pain.
Indoprofen, as isoindolinyl derivative, was evaluated as a postoperative analgesic in a randomized double-blind, between-patients study on 40 men with postgastrectomy pain. Single intravenous doses of 100 and 300 mg indoprofen and 0.5 and 1.5 Gm lysine acetylsalicylate (ASA) were compared in a four-point assay. The method of evaluation relied on subjective appraisal of pain relief by the patient for 6 hours after medication. The results demonstrate the analgesic efficacy of indoprofen in patients with severe postoperative pain, a dose-dependent effect, and a 13-to-16 potency ratio to ASA as judged from total pain relief.
D000328:Adult; D000704:Analysis of Variance; D001241:Aspirin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005743:Gastrectomy; D006801:Humans; D007216:Indoprofen / Q000627:therapeutic use*; D007275:Injections, Intravenous; D008239:Lysine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D010666:Phenylpropionates / Q000627:therapeutic use*
D010666:Phenylpropionates; D007216:Indoprofen; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate