Canine intervertebral disc disease: a review of etiologic and predisposing factors.
In this report the literature on etiologic and predisposing factors of disc disease in the dog is reviewed and discussed. Hypochondroplasia is considered to be important in the etiology of disc disease. After some consideration on nomenclature and morphology, the genetic background of hypochondroplasia is described. The histochemical morphological and developmental similarities and differences between and within various dog breeds are discussed. Macroscopically visible features that predispose to disc disease are outlined. The biomechanical bow-string model of the vertebral column is reviewed. In the discussion the various literature data are interrelated to show how disc disease might be reduced by breeding measures without implicating the breed characteristics. Literature recommendations to help the individual dog are included.
D000130:Achondroplasia / Q000209:etiology / Q000235:genetics / Q000662:veterinary*; D000375:Aging; D000818:Animals; D001835:Body Weight; D004283:Dog Diseases / Q000209:etiology* / Q000235:genetics; D004285:Dogs; D005260:Female; D006651:Histocytochemistry; D007403:Intervertebral Disc / Q000032:analysis / Q000254:growth & development; D008297:Male; D013045:Species Specificity; D009626:Terminology as Topic