Preparation and preliminary biodistribution of "no carrier added" fluorine1-8 fluoroethanol.
No-carrier-added [18F] fluoroethanol has been prepared by two routes. The first involves fluoride-ion displacement on alpha-p-toluene sulfonyl ethyl glycolate followed by reduction of the alpha-fluoroethyl acetate. The second involves a ring-opening reaction on glycol sulfite to give an alpha-fluorosulfinic acid derivative that is hydrolyzed to fluoroethanol. The specific activity was measured as 10(5) Ci/millimole, and the stable fluorine-19 was traced to the cesium hydroxide used to trap the H18F. Following intracarotid injection, the labeled fluoroethanol was not trapped in the brain, and thus is not a microsphere analog as has been suggested. Tomographic images of the myocardium were obtained using the fluoroethanol as a tracer.
D000818:Animals; D001921:Brain / Q000378:metabolism; D004285:Dogs; D000431:Ethanol / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism; D005461:Fluorine; D000882:Haplorhini; D007553:Isotope Labeling; D009206:Myocardium / Q000378:metabolism; D011868:Radioisotopes; D014055:Tomography, Emission-Computed
D011868:Radioisotopes; D005461:Fluorine; D000431:Ethanol; C001236:2-fluoroethanol