Vascular lesions and angiotensin in malignant hypertension in the absence of vasopressin.
1. Vasopressin deficient homozygous Brattleboro rats develop malignant renal hypertension following complete aortic-ligature between the renal arteries. 2. This form of hypertension is associated with high plasma renin activity (PRA) and plasma angiotensin II (AII) levels and a high incidence of the specific vascular lesions of fibrinoid necrosis in both Brattleboro and Long-Evans rats. 3. The levels of PRA and AII in the malignant hypertensive Brattleboro rats were not different from those in Long-Evans rats with malignant hypertension. 4. No compensation by the renin-angiotensin system therefore could be demonstrated for the lack of vasopressin in malignant hypertensive Brattleboro rats. 5. Vasopressin does not appear to be essential as a pressor hormone in the development of malignant renal hypertension and fibrinoid can occur in the absence of vasopressin.
D000804:Angiotensin II / Q000097:blood; D000809:Angiotensins / Q000502:physiology*; D000818:Animals; D001127:Arginine Vasopressin / Q000172:deficiency*; D001808:Blood Vessels / Q000473:pathology*; D006974:Hypertension, Malignant / Q000097:blood / Q000473:pathology* / Q000503:physiopathology; D009336:Necrosis; D051381:Rats; D011910:Rats, Brattleboro; D011919:Rats, Inbred Strains; D012083:Renin / Q000097:blood
D000809:Angiotensins; D000804:Angiotensin II; D001127:Arginine Vasopressin; D012083:Renin