[Trials of the use of live vaccines against brucellosis and listeriosis in farm animals].
A lyophilised live vaccine, developed on the basis of Listeria strain AUF (Serotype I), proved to provide adequate protection against all serotypes of listeriosis. The live vaccine was tested in field experiments over several years. Mortality among cattle, sheep, swine, and rabbit was considerably reduced in all immunisation areas, following several years of use in prophylaxis and after-care. Spectacular success was obtained from swine, with lethality having been lowered by the factor of 35. A live vaccine against brucellosis was developed on the basis of strain Brucella abortus 82. The properties of the strain are described. Its markedly pronounced immunogenicity is demonstrated in greater detail. Data are given on the use of the commercially available lyophilised vaccine which gave rates of success up to 100 per cent in certain contaminated areas. Work now is in progress on further optimisation of the vaccine and its large-scale manufacture at industrial level.
D000818:Animals; D000829:Animals, Domestic; D001428:Bacterial Vaccines / Q000276:immunology; D002004:Brucella Vaccine / Q000276:immunology; D002003:Brucella abortus / Q000276:immunology*; D002006:Brucellosis / Q000517:prevention & control / Q000662:veterinary*; D005612:Freeze Drying; D008087:Listeria / Q000276:immunology*; D008088:Listeriosis / Q000517:prevention & control / Q000662:veterinary*; D013045:Species Specificity
D001428:Bacterial Vaccines; D002004:Brucella Vaccine
Versuche zur Anwendung von Lebendimpfstoffen gegen Brucellose und Listeriose landwirtschaftlicher Nutztiere.