Studies on the biochemical effects of glibenclamide on alloxan diabetic rabbits.
Treatment of alloxan diabetic rabbits with glibenclamide, the most potent of the sulfonylureas, for a period of 2 months, significantly ameliorated the diabetic condition. It produced a decrease in serum and liver lipids, amino acids, serum urea, blood sugar and urine sugar; increase in body weight, serum and liver proteins, liver glycogen, glucose tolerance and serum and liver acid labile phosphates. The possible mechanism of action of this hypoglycemic agent is discussed.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D005905:Glyburide / Q000494:pharmacology*; D006029:Glycosuria; D050356:Lipid Metabolism; D008055:Lipids / Q000097:blood; D008099:Liver / Q000378:metabolism; D008297:Male; D010710:Phosphates / Q000097:blood / Q000378:metabolism; D011817:Rabbits
D001786:Blood Glucose; D008055:Lipids; D010710:Phosphates; D005905:Glyburide