Use of secondary alpha-hydrogen isotope effects in reactions of pyrimidine nucleoside/nucleotide metabolism: thymidylate synthetase.
D002250:Carbon Radioisotopes; D004352:Drug Resistance, Microbial; D005468:Fluorodeoxyuridylate; D007553:Isotope Labeling / Q000379:methods*; D007700:Kinetics; D007780:Lacticaseibacillus casei / Q000187:drug effects / Q000201:enzymology; D008727:Methotrexate / Q000494:pharmacology; D008780:Methyltransferases / Q000378:metabolism*; D013329:Structure-Activity Relationship; D013940:Thymidylate Synthase / Q000378:metabolism*; D014316:Tritium
D002250:Carbon Radioisotopes; D014316:Tritium; D005468:Fluorodeoxyuridylate; D008780:Methyltransferases; D013940:Thymidylate Synthase; D008727:Methotrexate