[Suppressive effects of graft versus host reaction on humoral immunity: consequences of homograft of chicken spleen on differentiation of the bursa of Fabricius].
By engrafting the chorio-allantoïs of Chick embryos with spleen fragments from homologous adult donors, one elicits a graft-versus-host disease. When the graft is performed before the bursa of Fabricius has reached the lymphoid differentiation state, the final follicular organization is greatly reduced. It seems that this suppression effect cannot be related to a diminution of the stem cell compartment available in the anlage but is a result of a direct impact on the mesenchyme and/or the epithelium of the bursa.
D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D000917:Antibody Formation; D002060:Bursa of Fabricius / Q000276:immunology* / Q000502:physiology; D002454:Cell Differentiation; D002642:Chick Embryo; D006087:Graft vs Host Reaction; D007165:Immunosuppression Therapy; D013154:Spleen / Q000276:immunology*; D014184:Transplantation, Homologous
D000469:Alkaline Phosphatase
Effets dépresseurs de la réaction du greffon contre l'hôte sur l'immunité humorale : étude des conséquences de l'homogreffe de rate de poulet sur la différenciation de la bourse de Fabricius.