Proteolysis of fibrinogen in healthy volunteers following major and minor vivo plasminogen activation.
Changes in immunoreactive fibrinopeptide A, fragment B beta 1-42 and fragment E were followed after major and minor in vivo plasminogen activation, after infusion of streptokinase and acylated streptokinase-plasminogen complex respectively, in healthy male volunteers. Major activation resulted in a dramatic rise in all three peptides, fragment E persisting in the circulation longest. Fragment B beta 1-42 was also markedly increased after minor systemic plasminogen activation despite apparently adequate levels of immediate antiplasmin.
D016255:Anistreplase; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D005342:Fibrinolysis / Q000187:drug effects*; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D005344:Fibrinopeptide A / Q000032:analysis; D006801:Humans; D008297:Male; D010958:Plasminogen / Q000008:administration & dosage / Q000032:analysis; D010960:Plasminogen Activators / Q000008:administration & dosage*; D013300:Streptokinase / Q000008:administration & dosage; D000979:alpha-2-Antiplasmin / Q000032:analysis
D005338:Fibrin Fibrinogen Degradation Products; D005343:Fibrinolytic Agents; D000979:alpha-2-Antiplasmin; C018543:fibrinogen fragment E; D005344:Fibrinopeptide A; D016255:Anistreplase; D005340:Fibrinogen; D010958:Plasminogen; D013300:Streptokinase; D010960:Plasminogen Activators