Receptor-based design of dihydrofolate reductase inhibitors: comparison of crystallographically determined enzyme binding with enzyme affinity in a series of carboxy-substituted trimethoprim analogues.
D004798:Enzymes / Q000378:metabolism; D004926:Escherichia coli / Q000201:enzymology; D005493:Folic Acid Antagonists; D008727:Methotrexate / Q000494:pharmacology; D008958:Models, Molecular; D008968:Molecular Conformation; D011955:Receptors, Drug; D014295:Trimethoprim / Q000031:analogs & derivatives* / Q000494:pharmacology; D014961:X-Ray Diffraction
D004798:Enzymes; D005493:Folic Acid Antagonists; D011955:Receptors, Drug; D014295:Trimethoprim; D008727:Methotrexate