Chemotaxis of human neutrophils and monocytes induced by Cryptococcus neoformans.
Chemotaxis of human neutrophils and monocytes was stimulated by sera activated with greater than or equal to 1.25 x 10(6) Cryptococcus neoformans. Leukocytes from five renal transplant recipients had depressed chemotactic responses to C. neoformans-activated sera when compared with normal subjects (P less than 0.05). Concentrations of cryptococcal capsular polysaccharide less than 1 mg/ml failed to generate chemotactic factors from sera.
D002630:Chemotactic Factors / Q000502:physiology*; D002634:Chemotaxis, Leukocyte; D003454:Cryptococcus / Q000502:physiology*; D003455:Cryptococcus neoformans / Q000502:physiology*; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D007165:Immunosuppression Therapy; D016030:Kidney Transplantation; D008223:Lymphoma / Q000097:blood; D009000:Monocytes / Q000502:physiology; D009504:Neutrophils / Q000502:physiology; D011135:Polysaccharides, Bacterial / Q000502:physiology
D002630:Chemotactic Factors; D011135:Polysaccharides, Bacterial; D006854:Hydrocortisone