Double-blind comparative clinical trial of carprofen versus diclofenac-Na in patients with coxarthrosis.
A randomized double-blind trial was performed in 50 patients with moderate to severe coxarthrosis, 25 receiving 300 mg carprofen and 25 150 mg diclofenac-Na daily in 3 doses. The patients were treated for 21 days. With regard to clinical effect (anti-inflammatory and analgesic), both carprofen and diclofenac-Na exhibited good efficacy; statistical evaluation failed to reveal a significant difference between the therapy groups for the parameters considered (Fisher's exact test, Mann-Whitney U-test). Few adverse reactions were registered; they were severe enough to justify interruption of treatment in 1 patient receiving carprofen and 3 receiving diclofenac-Na.
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002227:Carbazoles / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004008:Diclofenac / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006621:Hip Joint; D006801:Humans; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D010648:Phenylacetates / Q000627:therapeutic use*; D011897:Random Allocation
D000894:Anti-Inflammatory Agents, Non-Steroidal; D002227:Carbazoles; D010648:Phenylacetates; D004008:Diclofenac; C007005:carprofen