AD 6, a coronary dilating agent, stimulates PGI2 production in rat aorta ex vivo and in human endothelial cells in culture.
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects / Q000378:metabolism*; D002478:Cells, Cultured; D002866:Chromonar / Q000031:analogs & derivatives*; D003374:Coumarins / Q000494:pharmacology*; D004727:Endothelium / Q000187:drug effects / Q000378:metabolism; D011464:Epoprostenol / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D011247:Pregnancy; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D014471:Umbilical Veins / Q000187:drug effects / Q000378:metabolism; D014664:Vasodilation / Q000187:drug effects
D003374:Coumarins; D011453:Prostaglandins; C025945:cloricromen; D011464:Epoprostenol; D002866:Chromonar