Mutagenicity of 2,4-dinitrotoluene and its metabolites in Salmonella typhimurium.
2,4-Dinitrotoluene (2,4-DNT) and its metabolites (2A4NT, 4A2NT, 2,4-DNB, 2A4NB, 4A2NB, 2,4-DAT, 2N4AAT, 2A4AAT, 2A4AABA and 2,4-DNBA), and 2,4-dinitrobenzaldehyde (2,4-DNA1), putative metabolite of 2,4-DNT, were tested for mutagenicity in Salmonella typhimurium strains TA98 and TA100. 2,4-DAT, 2N4AAT, 2A4AAT, 2A4AABA and 2,4-DNBA were inactive for strains TA98 and TA100. 2,4-DNT itself was only a weak mutagen. Two aminonitrotoluenes (2A4NT and 4A2NT), two aminonitrobenzyl alcohols (2A4NB and 4A2NB) and 2,4-dinitrobenzyl alcohol (2,4-DNB) were increasingly mutagenic in that order, in both strains, however, they were only weak or weak mutagens at mM concentrations. In contrast with these compounds, 2,4-DNA1 was mutagenic even at microM concentrations in both strains. These results suggest that a high mutagenicity of 2,4-DNA1 may be correlated to the carcinogenicity of 2,4-DNT.
D000818:Animals; D001711:Biotransformation; D004136:Dinitrobenzenes / Q000378:metabolism / Q000633:toxicity*; D009153:Mutagens; D009578:Nitrobenzenes / Q000633:toxicity*; D051381:Rats; D012486:Salmonella typhimurium / Q000235:genetics*
D004136:Dinitrobenzenes; D009153:Mutagens; D009578:Nitrobenzenes; C016403:2,4-dinitrotoluene