Plasma amino acids in 3/sec spike-wave epilepsy.
Plasma levels of 14 amino acids were determined in 44 probands with 3/sec spike-wave epilepsy, 27 of their first-degree relatives, and 22 controls. Six ratios of metabolically related amino acids were also calculated. Statistically significant differences were found for 7/20 variables when the experimental and control probands were compared, and for 6/20 variables when the relatives were compared with controls. Tau, Asp, and Tau/Glu were decreased and Glu was was increased in both the experimental probands and their first degree relatives. When discriminant analysis was used, age- and sex-matched epileptic probands could be distinguished from the age- and sex-matched control probands with 100% accuracy employing only 3 amino acids (Asp, Glu, Val) and one ratio (Thr/Ser).
D000293:Adolescent; D000328:Adult; D000409:Alanine / Q000097:blood; D000596:Amino Acids / Q000097:blood*; D001224:Aspartic Acid / Q000097:blood; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000097:blood* / Q000235:genetics; D005260:Female; D005971:Glutamates / Q000097:blood; D005973:Glutamine / Q000097:blood; D005998:Glycine / Q000097:blood; D006801:Humans; D007532:Isoleucine / Q000097:blood; D007930:Leucine / Q000097:blood; D008297:Male; D008715:Methionine / Q000097:blood; D008875:Middle Aged; D010649:Phenylalanine / Q000097:blood; D012694:Serine / Q000097:blood; D013654:Taurine / Q000097:blood; D013912:Threonine / Q000097:blood; D014443:Tyrosine / Q000097:blood; D014633:Valine / Q000097:blood
D000596:Amino Acids; D005971:Glutamates; D007532:Isoleucine; D005973:Glutamine; D013654:Taurine; D013912:Threonine; D001224:Aspartic Acid; D014443:Tyrosine; D012694:Serine; D010649:Phenylalanine; D008715:Methionine; D007930:Leucine; D014633:Valine; D000409:Alanine; D005998:Glycine