On immunosurveillance in human cancer.
The extraordinarily high incidence of cancers of many different varieties--carcinomas and lymphomas--in organ-transplant patients being maintained for long periods of time with immunosuppressive drugs is briefly reviewed. The role of immunosurveillance as a primary defense mechanism against cancer in human beings is consistent with these observations and is in need of further investigation. Conceivably, this mechanism may play a somewhat different role in humans from what has been observed in most experimental animal models.
D000818:Animals; D002471:Cell Transformation, Neoplastic; D003524:Cyclosporins / Q000627:therapeutic use; D005796:Genes; D016027:Heart Transplantation; D006801:Humans; D007111:Immunity, Cellular; D007113:Immunity, Innate; D007157:Immunologic Surveillance; D007166:Immunosuppressive Agents / Q000009:adverse effects; D016030:Kidney Transplantation; D009365:Neoplasm Regression, Spontaneous; D009369:Neoplasms / Q000209:etiology / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D003524:Cyclosporins; D007166:Immunosuppressive Agents