Inhibitory effect of Pseudomonas aeruginosa on phagocytosis and killing of rabbit polymorphonuclear leukocytes.
Polymorphonuclear leukocyte (PMN)-resistant strains of Pseudomonas aeruginosa had the ability to interfere with phagocytosis of Escherichia coli, whereas PMN-sensitive strains of P. aeruginosa did not. When mice were infected with an ordinarily nonpathogenic strain of E. coli, addition of a PMN-resistant strain of P. aeruginosa gave a mortality considerably higher than that obtained with P. aeruginosa alone, whereas addition of a PMN-sensitive strain of P. aeruginosa gave a mortality not different from that observed with P. aeruginosa alone. This increased mortality in mixed infection with E. coli and PMN-resistant P. aeruginosa was obtained by facilitation of tissue invasion by both bacteria from the inoculum site.
D000818:Animals; D004926:Escherichia coli / Q000472:pathogenicity; D004927:Escherichia coli Infections / Q000276:immunology / Q000382:microbiology*; D051379:Mice; D009504:Neutrophils / Q000502:physiology*; D010587:Phagocytosis; D011552:Pseudomonas Infections / Q000276:immunology / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity / Q000502:physiology*; D011817:Rabbits