Jaundice associated with nonhepatic Staphylococcus aureus infection. Does teichoic acid have a role in pathogenesis?
A previously healthy young man developed jaundice early in the course of a febrile illness caused by an unrecognized deep-seated Staphylococcus aureus abscess. The serum bilirubin level peaked 11 days before the abscess was discovered and drained. During this time the bilirubin level returned to normal, circulating immune complexes were detected, and the serum free teichoic acid antibody titer was elevated. Indirect immunofluorescent staining of liver tissue for teichoic acid revealed 2+ nuclear fluorescence of the hepatocytes. These findings suggested that circulating free teichoic acid was deposited in the liver and may have had an endotoxin-like effect in the hepatocytes. With the appearance of specific antibody in the serum, circulating teichoic acid was neutralized and further hepatic injury ceased.
D000328:Adult; D001427:Bacterial Toxins / Q000009:adverse effects; D005455:Fluorescent Antibody Technique; D006801:Humans; D007565:Jaundice / Q000209:etiology* / Q000276:immunology / Q000378:metabolism; D008099:Liver / Q000032:analysis / Q000166:cytology; D008297:Male; D013203:Staphylococcal Infections / Q000150:complications* / Q000276:immunology; D013211:Staphylococcus aureus; D013682:Teichoic Acids / Q000009:adverse effects* / Q000032:analysis
D001427:Bacterial Toxins; D013682:Teichoic Acids