Effects of bacterial lipopolysaccharides (LPS) on leukocytes and platelets. Recent views on the pathophysiological role of LPS in the host.
Some effects of bacterial endotoxin on leukocytes and platelets are reviewed. The release of two mediators, Leukocyte Inhibiting Factor (LIF) and Tissue Factor (TF) from human mononuclear cells are described. These factors may play either beneficial effects (LIF) or noxious activities (TF liberation in certain pathological conditions). Regarding the activities of LPS on platelets the AA. report some personal data about the electrokinetic modification of platelets due to endotoxin. This LPS effect can be performed directly or via a lymphokine release, Platelet Slowing Factor (PSF). In the light of all the mentioned considerations, a scheme of interaction LPS/platelets is suggested.
D000818:Animals; D001778:Blood Coagulation Disorders / Q000209:etiology; D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D007962:Leukocytes / Q000187:drug effects* / Q000276:immunology; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008222:Lymphokines / Q000032:analysis / Q000378:metabolism; D051379:Mice; D011817:Rabbits; D051381:Rats; D013601:T-Lymphocytes / Q000276:immunology; D013925:Thromboplastin / Q000502:physiology
D008070:Lipopolysaccharides; D008222:Lymphokines; C010598:leukocyte inhibitory factor; D013925:Thromboplastin