Further details of a hypothesis for the initiation of genetic recombination from recognition sites.
Consideration of the initiation of genetic recombination from fixed sites recognised by an initiation complex, has provided more details of the envisaged mechanism and implications of a recent hypothesis. It has been shown that the hypothesis allows for more than one recombinogenic event to result from a single binding of the recombination initiation complex to a recognition site in a DNA duplex. This capacity can explain data from fungal systems which are apparently inconsistent with the Meselson-Radding model of genetic recombination with respect to the positional relationship between tracts of hybrid DNA and sites of crossing-over. A mechanism for conversion, involving hybrid DNA formation, but without mismatch correction has also been proposed on the basis of this capacity. It is suggested that the hypothesis may apply generally to genetic recombination, in prokaryotes as well as eukaryotes.
D003434:Crossing Over, Genetic; D004247:DNA / Q000378:metabolism; D008957:Models, Genetic; D009693:Nucleic Acid Hybridization; D011995:Recombination, Genetic
D004247:DNA