Dipyridamole: a potent stimulator of prostacyclin (PGI2) biosynthesis.
1 Dipyridamole (0.01 to 0.75 mM) increased prostacyclin (PGI2) biosynthesis from tritiated arachidonic acid in rat stomach fundus homogenates by 21 to 350%. The transformation of prostaglandin H2 (PGH2) to PGI2 by a microsomal fraction of pig aorta was stimulated by dipyridamole at 0.1 M by 63%. 2 In the isolated perfused heart of the rabbit dipyridamole at 1 and 5 micrograms/ml increased PGI2 release by 70% and 146% respectively. 3 Our results show a stimulation of the second step in PGI2 biosynthesis (from endoperoxides) by dipyridamole. This effect should be considered in relation to the therapeutic usage of the drug in myocardial infarction.
D000818:Animals; D001711:Biotransformation; D003326:Coronary Circulation; D004176:Dipyridamole / Q000494:pharmacology*; D011464:Epoprostenol / Q000096:biosynthesis*; D066298:In Vitro Techniques; D009206:Myocardium / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis*; D011463:Prostaglandins H / Q000378:metabolism; D051381:Rats; D013268:Stimulation, Chemical; D013552:Swine
D011453:Prostaglandins; D011463:Prostaglandins H; D004176:Dipyridamole; D011464:Epoprostenol; D011451:Prostaglandin-Endoperoxide Synthases