Increased activity of a phospholipid base-exchange system by the differentiation of neoplastic cells from the nervous system.
The activity of a base-exchange enzyme system, specific for the polar head-groups of brain phospholipids, was measured in both C 1300 mouse neuroblastoma (clone 41A3) and human glioma 138 MG cell lines. This base-exchange is thought to occur between free nitrogenous bases and membrane-bound phospholipids. The incorporation of free 14C-labeled ethanolamine and L-serine was determined in undifferentiated and morphologically differentiated cells. Both cell lines showed a significant increase in ethanolamine and L-serine incorporation upon differentiation.
D000818:Animals; D002460:Cell Line; D002999:Clone Cells; D004983:Ethanolamines / Q000378:metabolism; D005910:Glioma / Q000201:enzymology*; D006801:Humans; D008563:Membrane Lipids / Q000378:metabolism*; D051379:Mice; D009447:Neuroblastoma / Q000201:enzymology*; D010743:Phospholipids / Q000378:metabolism*; D012694:Serine / Q000378:metabolism
D004983:Ethanolamines; D008563:Membrane Lipids; D010743:Phospholipids; D012694:Serine