[Palatinite in type II diabetics. Effect on blood-glucose, serum-insulin, C-peptide and free fatty acids].
In a randomized cross-over study, 24 type II diabetics were given at first 50 g palatinite and later 50 g glucose or vice versa in the morning before food intake. After administration of glucose there was a definite rise in blood-glucose, serum-insulin and C-peptide concentrations. After palatinite the rise of blood-glucose as well as serum-insulin and C-peptide was significantly less. Subjective side-effects were noted only after a single high dose of palatinite. Nonetheless, palatinite appears to be suitable as a sugar substitute in a diabetic diet, since in comparison with glucose there are no significant changes in blood-sugar levels and no additional insulin consumption is induced. Furthermore, because of its low energetic utilization it has an advantage over other sugar substitutes.
D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis*; D002096:C-Peptide / Q000097:blood; D002986:Clinical Trials as Topic; D003920:Diabetes Mellitus / Q000097:blood* / Q000178:diet therapy; D004187:Disaccharides / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D007328:Insulin / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011897:Random Allocation; D013402:Sugar Alcohols; D013549:Sweetening Agents / Q000494:pharmacology*
D001786:Blood Glucose; D002096:C-Peptide; D004187:Disaccharides; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D013402:Sugar Alcohols; D013549:Sweetening Agents; C016640:Palatinit
Palatinit bei Type-II-Diabetikern. Wirkung auf Blutglucose, Seruminisulin, C-Peptid und freie Fettsäuren im Vergleich mit Glucose.