Protein binding of valproic acid in uremic patients.
Protein binding of valproic acid was studied in four uremic patients on long-term hemodialysis. Before dialysis, the free fraction was 0.31 +/- 0.11 (SD); this was larger than in nonuremic subjects. During hemodialysis, the free fraction increased significantly (p less than 0.01) in three patients (mean, 0.64 +/- 0.32 SD).
D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood; D011485:Protein Binding; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood*; D014635:Valproic Acid / Q000097:blood*
D014635:Valproic Acid