[Protein metabolism by rat brain synaptosomes during learning].
The synthesis and degradation of rat brain synaptosomal proteins were studied in three groups of animals: trained the behaviour pattern in the maze, "pseudo-trained" and control. These processes were assessed from protein specific radioactivity after 1, 3 days and after 1, 3, 6 and 9 weeks following intraventricular injection of 14C-lysine. The experiments showed three fractions differing in overall values of half-life (T50). An increase in specific radioactivity of brain proteins of trained animals was revealed as compared to that in "pseudo-trained" and control rats. T50 was recorded to rise for slow-metabolizing fractions of synaptosomal proteins of trained rats. Participation of synaptosomal proteins in the mechanisms of long-term memory is discussed.
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism* / Q000648:ultrastructure; D007858:Learning / Q000502:physiology*; D008239:Lysine / Q000378:metabolism; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D051381:Rats; D013574:Synaptosomes / Q000378:metabolism; D013997:Time Factors
D009419:Nerve Tissue Proteins; D008239:Lysine
Izuchenie obmena belkov sinaptosom golovnogo mozga krys pri obuchenii.