Nitroreductase-mediated metabolic activation of 2-amino-4-(5-nitro-2-furyl)thiazole and binding to nucleic acids and proteins.
D000818:Animals; D001711:Biotransformation; D002273:Carcinogens / Q000378:metabolism*; D005200:FANFT / Q000031:analogs & derivatives / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009601:Nitroreductases; D010088:Oxidoreductases / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D012343:RNA, Transfer / Q000378:metabolism*; D051381:Rats; D012441:Saccharomyces cerevisiae; D013844:Thiazoles / Q000378:metabolism*
D002273:Carcinogens; D011506:Proteins; D013844:Thiazoles; C024885:ANFT; D005200:FANFT; D012343:RNA, Transfer; D010088:Oxidoreductases; D009601:Nitroreductases