Isolation and characterization of ovine testicular and ovarian inhibin.
Low-molecular-weight (< 1500 daltons) peptides with inhibin activity have been isolated from sheep testes and ovaries by simple gel filtration. These peptides were capable of inhibiting the ovarian weight increase in hCG-primed immature female mice and also of suppressing the post-castration rise of serum FSH levels in adult male rats, suggesting similarities in their biological properties. Both testicular and ovarian inhibin were typsin sensitive and heat stable at 100 degrees C for 30 min and were shown to act by interfering with the production of a hypothetical FSH-RH.
D000818:Animals; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors* / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D006728:Hormones / Q000494:pharmacology; D007265:Inhibins; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D010053:Ovary / Q000032:analysis*; D011506:Proteins / Q000302:isolation & purification* / Q000494:pharmacology; D012756:Sheep; D013735:Testicular Hormones / Q000302:isolation & purification* / Q000494:pharmacology; D013737:Testis / Q000032:analysis*
D006728:Hormones; D011506:Proteins; D013735:Testicular Hormones; D007987:Gonadotropin-Releasing Hormone; D007265:Inhibins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone