Activation of pharmacologic agents to radical intermediates. Implications for the role of free radicals in drug action and toxicity.
D000818:Animals; D002468:Cell Physiological Phenomena; D002477:Cells / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D004358:Drug Therapy; D004798:Enzymes / Q000378:metabolism; D005609:Free Radicals; D006801:Humans; D007111:Immunity, Cellular; D008054:Lipid Peroxides / Q000378:metabolism; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy; D010084:Oxidation-Reduction; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010600:Pharmacology; D014116:Toxicology
D004798:Enzymes; D005609:Free Radicals; D008054:Lipid Peroxides; D004364:Pharmaceutical Preparations