Inhibitory action of gossypol on enzymes and growth of Trypanosoma cruzi.
Gossypol, a phenolic compound isolated from the cotton plant, is a powerful inhibitor of nicotinamide adenine dinucleotide-linked enzymes (alpha-hydroxyacid dehydrogenase and malate dehydrogenase) of Trypanosoma cruzi, the parasite that causes Chagas' disease. Parasites at the epimastigote stage that were incubated for 5 minutes with 100 micromolar gossypol were completely immobilized. Concentrations of gossypol as low as 0.01 micromolar markedly reduced the growth rate of T. cruzi in culture.
D000429:Alcohol Oxidoreductases / Q000378:metabolism; D006072:Gossypol / Q000494:pharmacology*; D007770:L-Lactate Dehydrogenase; D045022:Lactate Dehydrogenases; D008291:Malate Dehydrogenase / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism*; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000201:enzymology / Q000254:growth & development
D010088:Oxidoreductases; D000429:Alcohol Oxidoreductases; D045022:Lactate Dehydrogenases; D007770:L-Lactate Dehydrogenase; C071195:D-lactate dehydrogenase; D008291:Malate Dehydrogenase; C021379:D-2-hydroxyacid dehydrogenase; D006072:Gossypol