Immunological blockade of endogenous thyrotropin-releasing hormone produces hypothermia in rats.
Administration of anti-serum to thyrotropin-releasing hormone (TRH) into the lateral cerebral ventricle of rats produces a dose-dependent hypothermia. Neutralization of anti-TRH serum with excess TRH abolishes this hypothermic effect. These results suggest a thermoregulatory role for endogenous TRH in the rat central nervous system.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D007106:Immune Sera / Q000008:administration & dosage; D008297:Male; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000276:immunology / Q000502:physiology*
D007106:Immune Sera; D013973:Thyrotropin-Releasing Hormone