Dimethyl sulfoxide in experimental brain injury, with comparison to mannitol.
The effects of dimethyl sulfoxide therapy were studied in rhesus monkeys following a standardized occipitofrontal missile injury. This therapy resulted in substantially higher blood pressure, cerebral perfusion pressure, blood flow, and oxidative metabolism than those of a group of monkeys that had been treated similarly with mannitol, and than those of an untreated group.
D000818:Animals; D001930:Brain Injuries / Q000188:drug therapy*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D007427:Intracranial Pressure / Q000187:drug effects; D008253:Macaca mulatta; D008353:Mannitol / Q000494:pharmacology / Q000627:therapeutic use*; D010101:Oxygen Consumption / Q000187:drug effects; D014948:Wounds, Gunshot / Q000188:drug therapy
D008353:Mannitol; D004121:Dimethyl Sulfoxide