Pharmacokinetics of chlorthalidone. Dependence of biological half life on blood carbonic anhydrase levels.
The relationship between the whole blood concentration of carbonic anhydrase and the biological half life of chlorthalidone has been investigated in six volunteers. A linear relationship was observed and on the basis of this, a pharmacokinetic model to explain the long and variable biological half life of chlorthalidone is proposed and discussed.
D002256:Carbonic Anhydrases / Q000097:blood*; D002752:Chlorthalidone / Q000097:blood / Q000378:metabolism*; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D011485:Protein Binding
D002256:Carbonic Anhydrases; D002752:Chlorthalidone