Human placental lactogen and pregnancy-specific beta 1-glycoprotein in pregnant diabetic women.
Serum placental lactogen (hPL) and pregnancy-specific beta 1-glycoprotein (SP1) concentrations were measured in 16 insulin-dependent pregnant diabetic women and in 16 non-diabetic control subjects matched for placental weight. hPL concentrations were found to be significantly higher in diabetics with placental weight greater than 90th centile compared with those in (i) non-diabetic controls with placental weight greater than 90th centile and (ii) diabetics with placental weights less than 90th centile. SP1 concentrations were higher in both diabetic groups compared with those in their respective non-diabetic controls, but no difference existed between the two diabetic groups. In the control subjects infant birthweights were lower in the women with small placentae, but no such difference was observed between the two diabetic groups.
D001724:Birth Weight; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007328:Insulin / Q000627:therapeutic use; D009929:Organ Size; D010920:Placenta / Q000473:pathology; D010928:Placental Lactogen / Q000097:blood*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000032:analysis*; D011254:Pregnancy in Diabetics / Q000097:blood* / Q000188:drug therapy / Q000473:pathology; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000032:analysis*
D007328:Insulin; D011257:Pregnancy Proteins; D011268:Pregnancy-Specific beta 1-Glycoproteins; D010928:Placental Lactogen