Treatment of blepharitis and blepharoconjunctivitis: comparison of gentamicin-betamethasone, gentamicin alone and placebo.
At two university centres 46 patients presenting with symptomatic infective blepharitis or blepharoconjunctivitis participated in a double-blind study of a new antibiotic-steroid ointment containing gentamicin and betamethasone. There was no significant difference in response to 2 weeks of therapy between the patients treated with this ointment and those treated with either an ointment containing gentamicin alone or a placebo ointment. There was also no significant correlation between the clinical response and the results of the bacterial cultures of swabs obtained at the beginning and the end of the study. However, the patients treated with the placebo had a much higher rate of recurrence of their symptoms over a 6-week follow-up period. The patients who before treatment had associated rosacea, dry eyes and a long duration of symptoms showed a poor response to therapy.
D000293:Adolescent; D000328:Adult; D001623:Betamethasone / Q000627:therapeutic use*; D001762:Blepharitis / Q000188:drug therapy* / Q000382:microbiology; D002648:Child; D002986:Clinical Trials as Topic; D003231:Conjunctivitis / Q000188:drug therapy* / Q000382:microbiology; D004311:Double-Blind Method; D004338:Drug Combinations; D005141:Eyelid Diseases / Q000188:drug therapy*; D005260:Female; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D013203:Staphylococcal Infections / Q000188:drug therapy
D004338:Drug Combinations; D005839:Gentamicins; D001623:Betamethasone