Oligohydramnios and transient neonatal anuria: a possible association with the maternal use of prostaglandin synthetase inhibitors.
The chronic use of prostaglandin synthetase inhibitors is reported in a pregnant patient with severe juvenile rheumatoid arthritis. Aspirin and indomethacin, along with corticosteroids, were required to prevent significant progression of the disease. Pregnancy was complicated by oligohydramnios and intrauterine growth retardation. The infant suffered transient anuria. The effects of prostaglandin synthetase inhibitors on renal vascular function is reviewed, and a possible association between the chronic ingestion of these drugs and compromised renal function in the newborn is pointed out.
D000328:Adult; D001002:Anuria / Q000139:chemically induced*; D001171:Arthritis, Juvenile / Q000188:drug therapy; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D016861:Cyclooxygenase Inhibitors; D005260:Female; D005317:Fetal Growth Retardation / Q000139:chemically induced; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects*; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000139:chemically induced*; D008431:Maternal-Fetal Exchange; D006831:Polyhydramnios / Q000139:chemically induced*; D011247:Pregnancy
D016861:Cyclooxygenase Inhibitors; D003404:Creatinine; D007213:Indomethacin