Untoward effects following combined neuroleptic-lithium therapy. Cardiac arrhythmias and seizure.
This case study deals with a cardiac and respiratory arrest suffered by a manic patient on maintenance lithium therapy who was treated with chlorpromazine and haloperidol. A brief discussion is presented of the possible relationship of these arrests with the drug therapy and some suggestions are presented to avoid these complications.
D000328:Adult; D001145:Arrhythmias, Cardiac / Q000139:chemically induced*; D001714:Bipolar Disorder / Q000628:therapy*; D002746:Chlorpromazine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D004830:Epilepsy, Tonic-Clonic / Q000139:chemically induced*; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage*; D006323:Heart Arrest / Q000139:chemically induced; D006801:Humans; D008094:Lithium / Q000008:administration & dosage*; D012131:Respiratory Insufficiency / Q000139:chemically induced
D008094:Lithium; D006220:Haloperidol; D002746:Chlorpromazine