Functional consequences of inhibiting serotonin uptake with fluoxetine in rats.
Fluoxetine alone enhances central serotonin function as measured by a variety of test systems and potentiates the effects of serotonin precursors. Table 1 lists various effects of tryptophan or 5HTP that have been potentiated by fluoxetine. This potentiation or synergistic interactions between fluoxetine and L-5HTP constitute excellent evidence that any given effect is influenced by a serotonin synaptic connection.
D000700:Analgesics; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001792:Blood Platelets / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects; D005473:Fluoxetine / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects; D009474:Neurons / Q000378:metabolism; D011437:Propylamines / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D012702:Serotonin Antagonists; D012890:Sleep / Q000187:drug effects
D000700:Analgesics; D011437:Propylamines; D012702:Serotonin Antagonists; D005473:Fluoxetine; D012701:Serotonin