[Immunomodulating action of 2-methoxyethanol and homologous derivatives in rats].
The authors have measured the effects of methoxy-2 ethanol and derivatives or analogs on adjuvant arthritis in Rat, and the activity of methoxy-2 ethanol on humoral responsiveness to antigenic stimuli in Rat. Only methoxy-2 ethanol,1,2-dimethoxyethane and 1-methoxy 2 ethoxy ethane out of 13 tested derivatives, have an inhibitory activity on adjuvant arthritis. Methoxy-2 ethanol induces a significant depression of antibody production after immune stimuli and a significant effect on rejection of the skin graft. Although these results are of interest, toxicity of methoxy-2 ethanol will be a limiting factor for therapeutic use.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D001168:Arthritis / Q000188:drug therapy*; D001169:Arthritis, Experimental / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005026:Ethylene Glycols / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D051381:Rats
D005026:Ethylene Glycols; C005219:methyl cellosolve
Action immunomodulatrice du méthoxy-2 éthanol et de dérivés homologues chez le rat.