Effects of 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeO-THbetaC) on audiogenic seizures in DBA/2J mice.
It was found previously that 6-methoxy-1,2,3,4-tetrahydro-beta-carboline (6-MeO-THbetaC) increased brain concentration of the neurotransmitter serotonin (5-HT) and decreased the concentration of its metabolite 5-hydroxyindole acetic acid (5-HIAA) at the same time the compound attenuated audiogenic seizures (AGS) in DBA/2J mice. In the present study we determined the time-course and dose-response effects of 6-MeO-THbetaC for blockade of AGS. Drugs sharing common effects with 6-MeO-THbetaC were also tested. At a dose of 100 mg/kg, 6-MeO-THbetaC blocked AGS between 10 min and 12 hr after injection, with maximal inhibition at 1 hr at which time a dose-related decrease in AGS was also demonstrated. All of the drugs tested which blocked AGS, including 6-MeO-THbetaC, THbetaC, 5-Hydroxytryptophan, chlorimipramine and pargyline, have biochemical similarities suggesting that facilitating serotonin function may be responsible for seizure-attenuating effects.
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000161:Acoustic Stimulation; D000818:Animals; D001572:Benzofurans / Q000494:pharmacology; D002243:Carbolines / Q000494:pharmacology*; D015283:Citalopram; D002997:Clomipramine / Q000494:pharmacology; D003010:Clorgyline / Q000494:pharmacology; D005473:Fluoxetine / Q000494:pharmacology; D006247:Harmine / Q000031:analogs & derivatives / Q000494:pharmacology; D007211:Indoles / Q000494:pharmacology*; D008732:Methoxydimethyltryptamines / Q000494:pharmacology; D051379:Mice; D008811:Mice, Inbred DBA; D004130:N,N-Dimethyltryptamine / Q000494:pharmacology; D010293:Pargyline / Q000494:pharmacology; D011437:Propylamines / Q000494:pharmacology; D011814:Quipazine / Q000494:pharmacology; D012640:Seizures / Q000517:prevention & control*; D012642:Selegiline / Q000494:pharmacology
D001572:Benzofurans; D002243:Carbolines; D007211:Indoles; D008732:Methoxydimethyltryptamines; D011437:Propylamines; D005473:Fluoxetine; D015283:Citalopram; C002272:6-methoxytryptoline; D012642:Selegiline; D006247:Harmine; D011814:Quipazine; D010293:Pargyline; D006916:5-Hydroxytryptophan; D003010:Clorgyline; D002997:Clomipramine; D004130:N,N-Dimethyltryptamine