Development of acute myeloid leukaemia during lithium treatment.
Development of acute myeloid leukaemia in 2 patients given long-term lithium treatment for affective illness is reported. The 1st was a 49-year-old man who was found to have acute myelomonocytic leukaemia after about 1 year of lithium treatment. He died 2 days after admission from haemorrhagic pericarditis. The 2nd patients was a 32-year-old woman given lithium for about 12 years. Thereafter she developed acute myeloid leukaemia within a few months. A remission induction regime with daunorubicin and cytosine arabinoside was successful and she is now in a full remission state.
D000328:Adult; D000928:Antidepressive Agents / Q000009:adverse effects; D003863:Depression / Q000150:complications* / Q000188:drug therapy; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000139:chemically induced*; D008094:Lithium / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged
D000928:Antidepressive Agents; D008094:Lithium