Physical efficiency of the organism after blockade of carotid sinuses receptors.
The investigations were undertaken for tracing changes occurring in exercise-related metabolites and pressure of respiratory blood gases, for observing in this way the development of post-exercise restitution in animals with pharmacological blockade of the carotid sinuses. The experiments were done on control and experimental rats with sinus blockade produced by means of 1.0 microliter lignocaine injected into the area of the sinuses. The animals were subjected to a workload performing a work of 188.6 J/m/sec at a power of 0.104 of W/m/sec. The measurements included the heart rate, the amplitude of respiration rates, blood levels of glucose, lactate, pyruvate and LDH activity. In the arterial blood and venous blood the values of pO2 and pCO2, H+ concentration and base reserve and the index of O2 utilization were determined. Differences were found between the control group and the group with sinus receptor blockade with an earlier return of the determined values to their initial state in the experimental group. The increase of the O2 utilization index in the experimental animals paralleled the lactate fall and LDH rise, and H+ concentration was unchanged. These changes show that carotid sinuses receptors cooperate with the mechanisms regulating postexercise restitution.
D000818:Animals; D001340:Autonomic Nerve Block; D001786:Blood Glucose / Q000032:analysis; D002245:Carbon Dioxide / Q000097:blood; D002346:Carotid Sinus / Q000294:innervation*; D004526:Efficiency; D006339:Heart Rate / Q000187:drug effects; D007770:L-Lactate Dehydrogenase / Q000097:blood; D007773:Lactates / Q000097:blood; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D010100:Oxygen / Q000097:blood; D005082:Physical Exertion; D011311:Pressoreceptors / Q000187:drug effects*; D011773:Pyruvates / Q000097:blood; D051381:Rats; D012119:Respiration / Q000187:drug effects
D001786:Blood Glucose; D007773:Lactates; D011773:Pyruvates; D002245:Carbon Dioxide; D008012:Lidocaine; D007770:L-Lactate Dehydrogenase; D010100:Oxygen