The effects of diphenylhydantoin on rat behavior.
Animals were administered increasing doses of diphenylhydantoin (DPH) for 20 days. During withdrawal they were observed in an open field. The results suggest that chronic DPH administration leads to a central supersensitivity phenomenon. Possible interference of DPH with dopaminergic systems was discussed.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D010672:Phenytoin / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013375:Substance Withdrawal Syndrome
D010672:Phenytoin