The effects of naloxone on methylphenidate-induced mood and behavioral changes: a negative study.
The effects of naloxone on IV methylphenidate-induced mood, behavior, and neurohumoral changes were assessed in eight psychiatric inpatients. While methylphenidate alone produced anticipated changes, the indications for significant naloxone-methylphenidate interactions were minimal. It is speculated that larger doses of naloxone might be required to produce modification of the psychostimulant effects.
D001519:Behavior / Q000187:drug effects*; D004347:Drug Interactions; D004644:Emotions / Q000187:drug effects*; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D001523:Mental Disorders / Q000523:psychology; D008774:Methylphenidate / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood; D011569:Psychiatric Status Rating Scales; D013997:Time Factors
D008774:Methylphenidate; D009270:Naloxone; D011388:Prolactin; D013006:Growth Hormone