A role of the rostral hypothalamus in the regulation of LHRH release in baboons.
In the intact control baboons the plasma level of LH was elevated and reached a peak within 15 minutes after administration of 100 microgram synthetic LHRH. In addition, a second peak in plasma LH appeared within 90 minutes after LHRH injection. Supplementing these results, plasma level of estrogen was elevated within 30 minutes after LHRH injection. Subsequently, frontal deafferentation of the hypothalamus was performed in these baboons. After administration of 100 microgram synthetic LHRH in these frontally deafferented baboons the plasma level of LH was elevated and reached a peak within 15 minutes, as in the intact control baboons. However, there was no second LH peak within 90 minutes after LHRH injection, even though plasma estrogen was elevated within 30 minutes, as in the intact control baboons. It was found that the rostral hypothalamus in baboons is involved in the regulation of LHRH release which promotes to release LH within 90 minutes after LHRH injection.
D000818:Animals; D004967:Estrogens / Q000097:blood; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D000882:Haplorhini; D007031:Hypothalamus / Q000502:physiology*; D007032:Hypothalamus, Anterior / Q000187:drug effects / Q000502:physiology*; D007700:Kinetics; D007986:Luteinizing Hormone / Q000097:blood*; D010215:Papio / Q000502:physiology*
D004967:Estrogens; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone