[Effects of cis-platin on the contractile system of polymorphonuclear leukocytes].
The effects of cis-Platinum, a new antitumor drug, on guinea pig polymorphonuclear functions related to subplasmalemmal fibrillar structures, were investigated. The compound markedly decreased chemotaxis. Zymosan particles engulfment and degranulation. The depression of these leucocyte activities adds to the already known drug induced myelotoxicity .
D000818:Animals; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D002945:Cisplatin / Q000494:pharmacology*; D004926:Escherichia coli; D005966:Glucuronidase / Q000097:blood; D006168:Guinea Pigs; D008070:Lipopolysaccharides / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects*; D015054:Zymosan / Q000097:blood
D008070:Lipopolysaccharides; D015054:Zymosan; D005966:Glucuronidase; D002945:Cisplatin
Effetti del cis-platino sul sistema contrattile di leucociti polimorfonucleati.