Long-term captopril treatment in moderate to severe hypertension.
1 The long-term effects of the oral angiotensin-converting enzyme inhibitor captopril with the addition of a diuretic (chlorthalidone) were examined in 16 patients with moderate or grave hypertension. Of these, 14 had essential hypertension and two renovascular hypertension. 2 Blood pressure fell sharply in all patients and this antihypertensive effect was maintained during 2, 4, 6, 12, and 24-month follow-up periods. The efficacy of treatment was not predicted by basal values of plasma renin activity. 3 Urinary excretion of sodium and potassium increased, but the increases were never such as to modify significantly sodium and potassium serum concentration. 4 The long-term treatment was generally well tolerated.
D000328:Adult; D000368:Aged; D000450:Aldosterone / Q000097:blood; D001794:Blood Pressure / Q000187:drug effects; D002216:Captopril / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004232:Diuretics / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011187:Posture; D011392:Proline / Q000031:analogs & derivatives*; D012083:Renin / Q000097:blood
D004232:Diuretics; D000450:Aldosterone; D011392:Proline; D002216:Captopril; D012083:Renin