A simple preparation of N-phosphorylated lysine and arginine.
An improved specific synthesis of N-epsilon-phospholysine is described. Phosphorylation under basic conditions of the copper chelate of L-lysine with phosphorus oxychloride and subsequent removal of the copper ion affords N-epsilon-phospholysine as the sole phosphorylated product. Similar treatment of L-arginine yields N-omega-phosphoarginine as the sole product which is identical to that produced enzymatically.
D001120:Arginine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D002614:Chelating Agents; D055598:Chemical Phenomena; D002621:Chemistry; D002851:Chromatography, High Pressure Liquid; D003300:Copper; D008239:Lysine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D009943:Organophosphorus Compounds / Q000138:chemical synthesis; D010766:Phosphorylation
D002614:Chelating Agents; D009943:Organophosphorus Compounds; C015441:phospho-L-arginine; C025308:N-epsilon phospholysine; D003300:Copper; D001120:Arginine; D008239:Lysine