Sex hormone changes in male epileptics.
Mean plasma levels of LH, FSH, PRL, and sex-hormone binding globulin (SHBG) were raised in twenty-seven epileptics on anticonvulsants compared with age matched controls. Sexual activity appeared to be reduced. Anticonvulsant therapy results in raised SHBG levels which may be associated with a lowered free testosterone level as indicated by raised LH levels and lowered sexual activity.
D000328:Adult; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D005640:Follicle Stimulating Hormone / Q000097:blood; D006065:Gonadotropins, Pituitary / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010672:Phenytoin / Q000627:therapeutic use; D011388:Prolactin / Q000097:blood; D011627:Puberty; D012738:Sex Hormone-Binding Globulin / Q000097:blood*; D012725:Sexual Behavior / Q000187:drug effects; D013739:Testosterone / Q000097:blood*
D006065:Gonadotropins, Pituitary; D012738:Sex Hormone-Binding Globulin; D013739:Testosterone; D010672:Phenytoin; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone