[Role of GABA-ergic and dopaminergic mechanisms in the withdrawal syndrome after discontinuation of long-term phenazepam administration].
It has been shown that depakin, a GABA-ergic agonist, and alpha-methyl-DOPA that inhibits catecholamine synthesis are capable of removing the withdrawal syndrome (disturbed pavlovian behavior pattern and aggressiveness) occurring after discontinuance of long-term administration (30 days) of phenazepam to rats in a dose of 2 mg/kg. In contrast, bicucullin, a blocker of GABA-ergic receptors, thiosemicarbazide that inhibits GABA synthesis by the brain, disulfiram and 3,4-dioxyphenylalanine that increase dopamine and noradrenaline content in the barain aggravate the withdrawal syndrome after phenazepam is discontinued. The data obtained suggest a role of GABA-ergic and dopaminergic mechanisms in the emergence of the withdrawal syndrome after discontinuance of long-term administration of benzdiazepins.
D006916:5-Hydroxytryptophan / Q000627:therapeutic use; D000818:Animals; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000009:adverse effects*; D001921:Brain / Q000503:physiopathology*; D004295:Dihydroxyphenylalanine / Q000627:therapeutic use; D004221:Disulfiram / Q000627:therapeutic use; D004298:Dopamine / Q000502:physiology*; D006801:Humans; D008297:Male; D008750:Methyldopa / Q000627:therapeutic use; D051381:Rats; D012663:Semicarbazides / Q000627:therapeutic use; D013375:Substance Withdrawal Syndrome / Q000188:drug therapy / Q000503:physiopathology*; D014635:Valproic Acid / Q000627:therapeutic use; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D012663:Semicarbazides; D001569:Benzodiazepines; C017928:phenazepam; D005680:gamma-Aminobutyric Acid; D008750:Methyldopa; C005151:thiosemicarbazide; D014635:Valproic Acid; D004295:Dihydroxyphenylalanine; D006916:5-Hydroxytryptophan; D004221:Disulfiram; D004298:Dopamine
Rol' GAMK-ergicheskikh i dofaminergicheskikh mekhanizmov razvitii sindroma "otdachi" posle prekrashcheniia dlitel'nogo vvedeniia fenazepama.