[Genetic control of antibiotic resistance and the R plasmid properties of clinical E. coli strains].
The electrophoretic analysis of the plasmid DNA of multiresistant clinical E. coli strains revealed the presence of extrachromosomal DNA in 97% of the strains. The plasmid nature of resistance was established in 88-100% of E. coli strains resistant to chloramphenicol, ampicillin, streptomycin or kanamycin and in 67% of the strains resistant to tetracyclin. 24 out of 40 strains contained conjugative R-plasmids in which the determinants of resistance to kanamycin, ampicillin and chloramphenicol were transferred most frequently (82-93%), while the determinants of resistance to tetracyclin and streptomycin were transferred less frequently (45% and 35%, respectively). Nonconjugative R-plasmids were detected in 15 out of 40 antibiotic-resistant strains; in these plasmids the determinants of resistance to streptomycin (65%) and tetracyclin (22%) were transferred most frequently.
D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors*; D002876:Chromosomes, Bacterial / Q000187:drug effects; D003227:Conjugation, Genetic; D004352:Drug Resistance, Microbial; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D005798:Genes, Bacterial / Q000187:drug effects; D010957:Plasmids / Q000187:drug effects*; D011815:R Factors / Q000187:drug effects*; D014169:Transformation, Bacterial / Q000187:drug effects
D000900:Anti-Bacterial Agents
Geneticheskiĭ kontrol' antibiotikorezistentnosti i svoĭstva R-plazmid klinicheskikh shtammov E. coli.