Prevention of transfusion-induced Chagas' disease by amphotericin B.
Amphotericin B, a polyene antibiotic effective against eukaryotic cells, can eliminate the trypomastigote form of Trypanosoma cruzi from blood stored at 4 degrees C. This antitrypanosomal effect can be achieved with a concentration of 3 micrograms/ml within 48 hours. This concentration of amphotericin B does not produce hemolysis over a period of 3 weeks. Amphotericin B methyl ester and nystatin are not effective. Amphotericin B may be considered as a replacement for crystal violet in blood bank blood to prevent transfusion-induced Chagas' disease.
D000666:Amphotericin B / Q000627:therapeutic use*; D000818:Animals; D001938:Brazil; D014355:Chagas Disease / Q000517:prevention & control*; D006461:Hemolysis / Q000187:drug effects; D051379:Mice; D065227:Transfusion Reaction
D000666:Amphotericin B