Stimulation of human pancreatic polypeptide secretion by hypoglycemia is independent of adrenergic mechanisms.
Human pancreatic polypeptide (HPP) increases after insulin-induced hypoglycemia. To determine whether adrenergic mechanisms contribute to this increase in normal man, six subjects were studied on two occasions: once after insulin alone and once after insulin plus simultaneous alpha (phentolamine)- and beta (propranolol)-adrenergic blockade. Despite comparable hypoglycemia (51 +/- 4 vs. 49 +/- 4 mg/dl), the increase in HPP did not differ in the presence or absence of adrenergic blockade (721 +/- 215 vs. 736 +/- 193 pg/ml, respectively). These findings suggest that HPP secretion during hypoglycemia is not dependent on adrenergic mechanisms.
D000328:Adult; D005260:Female; D006801:Humans; D007003:Hypoglycemia / Q000097:blood* / Q000139:chemically induced / Q000503:physiopathology; D007328:Insulin / Q000494:pharmacology; D008297:Male; D010191:Pancreatic Polypeptide / Q000097:blood / Q000378:metabolism*; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D007328:Insulin; D010191:Pancreatic Polypeptide; D011433:Propranolol; D010646:Phentolamine