Carcinogenicity of N-nitroso compounds. Species and route differences in regard to organotropism.
N-nitroso compounds were found to be carcinogenic in 22 animals species. The organotropism of the carcinogenic action may be related to a variety of organs and organ systems. It does not only depend on the chemical structure of the molecules but also on the daily dose. It is highly probable that N-nitroso compounds also act carcinogenically in human beings. Predictions as to the organotropism of the carcinogenic action in man cannot be made. N-nitroso compounds have to be regarded as 'multipotent'.
D000818:Animals; D001001:Anura; D002273:Carcinogens; D002415:Cats; D002645:Chickens; D006224:Cricetinae; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D005399:Fishes; D005849:Gerbillinae; D006168:Guinea Pigs; D000882:Haplorhini; D006364:Hedgehogs; D007928:Lethal Dose 50; D008431:Maternal-Fetal Exchange; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009603:Nitroso Compounds / Q000008:administration & dosage / Q000633:toxicity*; D009928:Organ Specificity; D010240:Parakeets; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013329:Structure-Activity Relationship
D002273:Carcinogens; D009603:Nitroso Compounds