Some evidence for interaction of D-cycloserine with DNA.
D-Cycloserine showed a decreased lethality against paraquat-treated E. coli than against non-treated cells. E. coli K12 mutants which were deficient in DNA repair were more sensitive than the wild type strain to D-cycloserine. Furthermore, D-cycloserine caused PM2 DNA cleavage in the presence of Fe2+, and the cleavage was strongly inhibited by singlet oxygen scavengers. These results indicate that D-cycloserine interacts with DNA and an active oxygen species is involved in the interaction.
D003523:Cycloserine / Q000494:pharmacology*; D004260:DNA Repair; D004269:DNA, Bacterial; D004352:Drug Resistance, Microbial; D004790:Enzyme Induction; D004926:Escherichia coli / Q000187:drug effects / Q000201:enzymology; D009154:Mutation; D009691:Nucleic Acid Denaturation; D010100:Oxygen; D010269:Paraquat / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000378:metabolism
D004269:DNA, Bacterial; D003523:Cycloserine; D013482:Superoxide Dismutase; D010269:Paraquat; D010100:Oxygen