Physical training in juvenile diabetes.
In normal man, physical training increase insulin binding to receptors and body sensitivity to insulin in vivo. In addition, serum lipid and lipoprotein profile changes which may decrease the risk for coronary heart disease. In juvenile onset diabetics, insulin requirements fall during physical training, the mechanism of this decline being yet unknown. There are no prospective studies regarding the prognostic effects of physical training in juvenile diabetes. However, if physical training can improve metabolic control and enhance body sensitivity to insulin resulting in lowered levels of plasma insulin, this may reduce the risk for both micro- and macrovascular complications. The possible adverse effects of exercise, hypoglycemia and excessive rise in counterregulatory hormones can be largely avoided by adequate insulin therapy.
D000328:Adult; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002395:Catecholamines / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000378:metabolism / Q000628:therapy*; D005934:Glucagon / Q000097:blood; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007273:Injections, Intramuscular; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use; D010806:Physical Education and Training; D051381:Rats
D001786:Blood Glucose; D002395:Catecholamines; D007328:Insulin; D013006:Growth Hormone; D005934:Glucagon