[Influence of age, season and hypophysectomy on lipogenesis of adipocyte from rabbit. Insulin effects].
We studied lipogenesis, either from glucose or from acetate, spontaneous or stimulated by insulin, at the level of the isolated adipocyte of the rabbit's perirenal adipose tissue related to growth, season and hormonal troubles induced by hypophysectomy. 1. For the adipocyte, acetate instead of glucose is the major precursor for fatty acid synthesis. 2. Adipocyte lipogenesis of the immature rabbit of two months is higher than that which is observed in the mature rabbit of six months. 3. Adipocyte lipogenesis is strikingly more important in autumn than in spring, both in the young rabbit and the mature one. 4. After hypophysectomy, fatty acid synthesis from acetate is greatly increased at the level of the adipocyte and, in this case, insulin stimulates efficiently lipogenesis from acetate as well as from glucose.
D000085:Acetates / Q000378:metabolism; D000273:Adipose Tissue / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D000375:Aging; D000818:Animals; D005947:Glucose / Q000378:metabolism; D007016:Hypophysectomy; D007328:Insulin / Q000494:pharmacology*; D050356:Lipid Metabolism; D011817:Rabbits; D012621:Seasons; D013997:Time Factors
D000085:Acetates; D007328:Insulin; D005947:Glucose
Influences de l'âge, de la saison et de l'hypophysectomie sur la lipogenèse de l'adipocyte chez le lapin; effects de l'insuline.