[Possibility of using antioxidants in the combined chemotherapy of tumors].
Based on studies of the antioxidative activity of lipids (aoa) of the organs and tissues of tumor-bearing animals during tumor growth, it is suggested to use the following schedule of combined chemotherapy of tumors: at early terms of tumor progression, when the level of aoa in the organs of a tumor-bearing animal is maximum, to inject alkylating agents which sharply reduce the aoa level, when their level in tissue is low to inject synthetic antioxidants which raise it.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D002084:Butylated Hydroxytoluene / Q000008:administration & dosage; D004353:Drug Evaluation, Preclinical; D004359:Drug Therapy, Combination; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000401:mortality; D051379:Mice; D009368:Neoplasm Transplantation; D013852:Thiotepa / Q000008:administration & dosage; D013997:Time Factors
D000975:Antioxidants; D002084:Butylated Hydroxytoluene; D013852:Thiotepa
O vozmozhnosti ispol'zovaniia antioksidantov v kombinirovannoĭ khimioterapii opukholeĭ.