[Do prostaglandins protect other cells besides those of the gastrointestinal epithelium?].
Prostaglandins in very low concentrations, which do not inhibit acid secretion, do protect the mucosa of the gastrointestinal tract against a great number of noxious agents. Similar effects could be shown recently in hepatic, pancreatic, renal, and myocardial tissue. The mechanism of cytoprotective action remains unclear. Since cytoprotection is quite ubiquitous, a common mechanism as for instance stabilisation of membranes seems to be effective. It remains to be seen, if this protective action of prostaglandins can be used in therapy.
D000208:Acute Disease; D000818:Animals; D002415:Cats; D003327:Coronary Disease / Q000188:drug therapy; D015232:Dinoprostone; D011464:Epoprostenol / Q000494:pharmacology* / Q000627:therapeutic use; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000166:cytology / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000188:drug therapy; D051379:Mice; D010195:Pancreatitis / Q000188:drug therapy / Q000209:etiology; D011453:Prostaglandins / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats
D011453:Prostaglandins; D011458:Prostaglandins E; D011464:Epoprostenol; D015232:Dinoprostone
Wirken Prostaglandine auch ausserhalb des Magen-Darm-Epithels zytoprotektiv?