Monocyte functional defects in rheumatoid arthritis.
Monocytes derived from peripheral blood of patients with rheumatoid arthritis (RA) had a marked defect in their chemotactic and phagocytic activity. The chemotactic defect resides at a cellular level, while the phagocytic defect is serum-dependent. Both defects could be of importance in the pathogenicity of RA and the susceptibility to infection such patients show. Finally, monocytes were found to have a negative influence over spontaneous cytotoxicity mediated by T lymphocytes.
D001172:Arthritis, Rheumatoid / Q000097:blood / Q000276:immunology*; D002634:Chemotaxis, Leukocyte; D003601:Cytotoxicity Tests, Immunologic; D006801:Humans; D007961:Leukocyte Migration-Inhibitory Factors / Q000097:blood; D009000:Monocytes / Q000276:immunology*; D010587:Phagocytosis; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D007961:Leukocyte Migration-Inhibitory Factors