[Effect of plasmid pKM101 on the mutability of salmonella strains exposed to polycyclic aromatic hydrocarbons].
The carcinogenic polycyclic aromatic hydrocarbons have been shown to induce frameshift mutations rather than base-pair substitutions in Ames test strains devoid of pKM101 plasmid. This plasmid enhances the frequency of induced frameshift mutations and mediates the induction of base-pair substitutions during the action of these carcinogens. No correlation was observed between the degree of mutagenesis induced in plasmid-containing and in plasmid-free strains by the test agents and their reported carcinogenic activity.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000633:toxicity; D000818:Animals; D001551:Benz(a)Anthracenes / Q000633:toxicity; D001580:Benzopyrenes / Q000633:toxicity; D008297:Male; D009154:Mutation; D010957:Plasmids; D011083:Polycyclic Compounds / Q000633:toxicity*; D051381:Rats; D012475:Salmonella / Q000235:genetics*
D001551:Benz(a)Anthracenes; D001580:Benzopyrenes; D011083:Polycyclic Compounds; D015127:9,10-Dimethyl-1,2-benzanthracene
Vliianie plazmidy pKM101 na mutabel'nost' shtammov sal'monell pod deĭstviem politsiklicheskikh aromaticheskikh uglevodorodov.