[Toxicity of single and multiple administrations of phosphorus-containing isothiuronim derivatives possessing radioprotective properties].
Acute toxicity of ethylphosphate, diethylphosphate and metaphosphate of S-ethylisothiuronium does not differ significantly when the drugs are administered to albino female mice intraperitoneally, intramuscularly or subcutaneously. However, this toxicity diminishes 4--5-fold during intragastric administration. The substances are approximately 100 mg/kg more toxic for Wistar rats as compared to mice. The radioprotective doses of the compounds administered intramuscularly ten times exert no effect on the rat behaviour, weight, peripheral blood composition, weight coefficients or histological structure of the internal organs.
D000818:Animals; D001769:Blood / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D005260:Female; D007550:Isothiuronium / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D007928:Lethal Dose 50; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D011837:Radiation-Protective Agents; D051381:Rats; D013890:Thiourea / Q000031:analogs & derivatives*; D013997:Time Factors
D011837:Radiation-Protective Agents; D007550:Isothiuronium; D013890:Thiourea
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