Synthesis and antiinflammatory activity of some 2-(substituted-pyridinyl)benzimidazoles.
A series of 2-(2-pyridinyl)benzimidazoles was synthesized and evaluated for antiinflammatory activity by the carrageenan-induced rat paw edema assay. Among several active derivatives, 2-(5-ethylpyridin-2-yl)benzimidazole (6) was selected for further study. A comparison of compound 6 with phenylbutazone and tiaramide revealed that 6 possesses stronger activity in acute inflammatory models possibly with slightly less gastrointestinal irritation than both phenylbutazone and tiaramide.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis; D001562:Benzimidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors; D004487:Edema / Q000188:drug therapy; D051379:Mice; D051381:Rats; D012995:Solubility; D013276:Stomach Ulcer / Q000139:chemically induced; D013329:Structure-Activity Relationship
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001562:Benzimidazoles; D016861:Cyclooxygenase Inhibitors