The first cases of Fitzgerald factor deficiency in the Orient: three cases in one family.
Asymptomatic, female, 56-year-old identical Japanese twins were found to have a severe abnormality in the surface-mediated intrinsic coagulation, fibrinolysis and esterolytic activity. These defects were thought to be due to the lack of Fitzgerald factor, because of the prolongations of kaolin-activated partial thromboplastin time and kaolin-activated euglobulin lysis time that were not corrected by the addition of Fitzgerald trait-plasma but were corrected to normal levels by the addition of isolated bovine high-molecular-weight kininogen, Fletcher trait-plasma or Hageman trait-plasma.
D000818:Animals; D001778:Blood Coagulation Disorders / Q000188:drug therapy / Q000453:epidemiology*; D001780:Blood Coagulation Tests; D002417:Cattle; D005173:Factor XI Deficiency / Q000097:blood; D005175:Factor XII Deficiency / Q000097:blood; D005260:Female; D006801:Humans; D007564:Japan; D007704:Kininogens / Q000627:therapeutic use; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D010375:Pedigree; D011288:Prekallikrein / Q000378:metabolism
D007704:Kininogens; D011288:Prekallikrein