A study of fluctuations in Escherichia coli sensitivity patterns from pigs fed a halquinol supplemented diet.
Escherichia coli isolated from pigs fed on a medicated diet containing 120 p.p.m. halquinol did not develop any resistance to this addition over a 6-week period. Sensitivity patterns of the E. coli isolates to eight antimicrobial substances, although fluctuating slightly during the test period (but no more than a control group), did not significantly alter. However, the patterns did change significantly when for 17 days after the completion of the halquinol trial the pigs were fed a normal commercial ration medicated with a commonly used feed additive containing chlortetracycline hydrochloride, procaine penicillin and sulphadimidine.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002739:Chloroquinolinols / Q000494:pharmacology*; D004032:Diet; D004926:Escherichia coli / Q000187:drug effects*; D005503:Food Additives / Q000494:pharmacology*; D006912:Hydroxyquinolines / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D012007:Rectum / Q000382:microbiology; D013552:Swine / Q000382:microbiology*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D002739:Chloroquinolinols; D005503:Food Additives; D006912:Hydroxyquinolines; C011838:halquinol