Relationship between chronic PaCO2 and total body buffering capacity in patients with chronic obstructive lung disease.
17 subjects were carefully selected among 150 patients with COLD: all patients with one or more conditions or diseases that could alter the physiological response to chronic hypercapnia were eliminated. During a period of 13 to 28 days, the acid-base response to slow carbon dioxide changes was studied in the selected patients. Total body buffering capacity was expressed as dH+a/dPaCO2 and showed to be an inverse function of chronic PaCO2 (defined as the value of PaCO2 in clinical and acid-base steady status for each patient), according to the previous suggestions of Weiss and Dulfano and to the report of Ingram and co-workers during acute carbon dioxide changes in the same patients.
D000136:Acid-Base Equilibrium; D002245:Carbon Dioxide / Q000097:blood*; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000097:blood / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D013997:Time Factors
D002245:Carbon Dioxide; D010100:Oxygen