Reinnervation of the olfactory bulb after section of the olfactory nerve in monkey (Saimiri sciureus).
Section of the fila olfactoria in squirrel monkey, a non-human primate, induces rapid degeneration of the sensory axon terminals in the olfactory bulb glomeruli. A population of axons, from newly formed sensory neurons in the olfactory neuroepithelium, regrow, passes the lamina cribrosa and, upon reaching the olfactory bulb, reinnervates the glomeruli. A new set of synaptic contacts is reformed between the sensory terminals and the post-synaptic dendritic processes of the glomeruli. Our observations indicate that this portion of the CNS of a non-human primate can be reinnervated after deafferentiation, and that active synaptogenesis occurs.
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D002490:Central Nervous System / Q000033:anatomy & histology*; D003712:Dendrites / Q000648:ultrastructure; D003714:Denervation; D000882:Haplorhini; D008297:Male; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure; D009416:Nerve Regeneration; D009830:Olfactory Bulb / Q000033:anatomy & histology*; D009832:Olfactory Nerve / Q000033:anatomy & histology*; D009833:Olfactory Pathways / Q000033:anatomy & histology*; D012453:Saimiri; D013569:Synapses / Q000648:ultrastructure