Capsula-protected homotransplantation - a hypothesis on bypassing immunological rejection in allogeneic organ transplantation.
By influencing fetal brain development pregnancy may be prolonged beyond term for an unknown time period. In late gestation the mother animal (host) is nephrectomized. The urine of the fetus (transplant) is guided to the outside so that the fetal kidneys excrete the host's urinary secretory substances and eventually hypertrophy. The literature on hypertrophy of the (fetal) kidney, placental passage of urinary secretory substances, endocrine function of the (fetal) kidney and extrarenal tissue, prolongation of gestation, and some aspects of the immunological protection of the fetus is critically reviewed. Conclusions as to the eventual realisation of this hypothetic model of organ allotransplantation without rejection are set forth.
D000818:Animals; D005260:Female; D005333:Fetus / Q000502:physiology; D006084:Graft Rejection; D006801:Humans; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008431:Maternal-Fetal Exchange; D009392:Nephrectomy; D010063:Ovum / Q000637:transplantation; D010920:Placenta / Q000502:physiology*; D011247:Pregnancy; D014181:Transplantation Immunology; D014184:Transplantation, Homologous