Antagonism by classical antiepileptics and sodium valproate of cefazolin in induced experimental epilepsy in rats.
The effects of cefazolin, a semisynthetic cephalosporin, on rat behavior, electrocortical activity and on electrocortical spectrum power were evaluated. In addition, the possible antagonism by some antiepileptic agents was studied. Cegazolin, given intravenously in rats, produced generalized convulsions, electrocortical high-voltage spikes and other electrocortical abnormalities similar to those described to occur in human epilepsy. Power spectrum analysis of the electrocortical activity revealed a significant increase in total voltage output during electrocortical epileptogenic discharges. In addition high-voltage spikes induced by cefazolin were easily counted and lasted approximately 90 min. Classical antiepileptic drugs (diphenylhydantoin, phenobarbital and clonazepam as well as sodium valproate were able to counteract electroclinical disorders induced by cefazolin.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001522:Behavior, Animal / Q000187:drug effects; D002437:Cefazolin / Q000037:antagonists & inhibitors*; D004569:Electroencephalography; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D014635:Valproic Acid / Q000494:pharmacology*
D000927:Anticonvulsants; D014635:Valproic Acid; D002437:Cefazolin