Mutagenicity evaluation of KB-944, a new calcium antagonist, in the Ames bacterial system.
Evaluation of the mutagenic activity of diethyl 4-(benzothiazol-2-yl) benzylphosphonate (KB-944) was performed using bacteria. The method consisted of mutagens or KB-944 with and without metabolic activation, and two bacteria; Salmonella typhimurium 5 test strains, TA 1535, TA 100, TA 1537, TA 1538 and TA 98, and Escherichia coli WP 2 uvr A. Results indicated that KB-944 had no mutagenic activity against S. typhimurium and E. coli.
D052160:Benzothiazoles; D002121:Calcium Channel Blockers / Q000633:toxicity*; D004926:Escherichia coli / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D012486:Salmonella typhimurium / Q000235:genetics; D013844:Thiazoles / Q000494:pharmacology*; D014364:Tryptophan / Q000378:metabolism
D052160:Benzothiazoles; D002121:Calcium Channel Blockers; D009153:Mutagens; D013844:Thiazoles; D014364:Tryptophan; C035950:fosfedil