[Comparative study of the distribution of 7,12-dimethylbenz(a)anthracene in the organs of pregnant rats and their fetuses].
On the 21st day of pregnancy rats were injected intravenously with 7,12-dimethylbenz(a)anthracene (DMBA) in a dose of 15 mg/kg. After 30, 60 and 180 min the content of the preparation was determined by the fluorescent-spectral method in the organs of females (liver, kidneys, lungs, brain, spleen and placenta) and in their fetuses (liver, kidneys, lungs, brain, intestine, "carcasses" and intact fetus). In the course of all experimental periods the female rats showed the highest concentration of DMBA in the lungs. The concentration of DMBA in all organs of pregnant rats diminished while in the brain it increased with time elapsed after injection. The fetuses showed uneven distribution of the carcinogen in the organs only 60 min after DMBA injection, the highest content being recorded in the liver. The maximum content of the carcinogen was detected in all organs of the fetus by the 60th minute. DMBA accumulation in fetal organs did not correlate with the evidence on predominant occurrence of tumours in the kidneys and the nervous system of the progeny in transplacental effect of DMBA administered in the same dose.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000378:metabolism*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene
Sravnitel'noe izuchenie raspredeleniia 7,12-dimetilbenz(a)antratsena v organakh beremennykh krys i ikh plodov.