Transition from neurogenic to myogenic receptivity for thyrotropin-releasing hormone (TRH) in the duodenum of the neonatal rat.
A tetrodotoxin- and hexamethonium-sensitive response to thyrotropin-releasing hormone (TRH), an in vitro contraction, first appeared in the duodenum of the 3 day old rat, was increased by day 16, decreased there-after and was extinguished after weaning. A tetrodotoxin-resistant response to TRH, a relaxation, appeared at day 13 and became distinct after weaning. The development of neurogenic receptivity for TRH precedes the appearance of myogenic receptivity in the rat duodenum.
D000109:Acetylcholine / Q000494:pharmacology; D000375:Aging; D000828:Animal Population Groups / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D000833:Animals, Suckling / Q000502:physiology*; D004386:Duodenum / Q000502:physiology; D005260:Female; D006584:Hexamethonium Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000502:physiology*; D051381:Rats; D012601:Scopolamine / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*; D014700:Verapamil / Q000494:pharmacology
D006584:Hexamethonium Compounds; D013779:Tetrodotoxin; D013973:Thyrotropin-Releasing Hormone; D014700:Verapamil; D012601:Scopolamine; D000109:Acetylcholine