Cardioselectivity of atenolol and metoprolol. A study in asthmatic patients.
Eight asthmatic patients were investigated in a double-blind cross-over study after oral administration of 100 mg atenolol, 10 mg metoprolol and placebo. Four increasing doses of terbutaline (0.036-1.23 micrograms kg-1 min-1) were thereafter administered by intravenous infusion, starting 120 min after the tablet intake. The infusions were given for 6 min on each dose level with 30-min intervals. The study was finished by inhalation of six terbutaline puffs (1.5 mg). Both atenolol and metoprolol lowered resting heart rate and FEV1 significantly and produced a down- and rightward shift of the dose-response curves to infused terbutaline. No differences between effects of the two beta-blockers were shown in reduction of heart rate and FEV1, before and during the terbutaline treatments. Differences in cardioselectivity between atenolol and metoprolol could thus not be shown.
D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy* / Q000503:physiopathology; D001262:Atenolol / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D005541:Forced Expiratory Volume; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000627:therapeutic use*; D008875:Middle Aged; D009119:Muscle Contraction / Q000187:drug effects; D005082:Physical Exertion; D011412:Propanolamines / Q000627:therapeutic use*; D013726:Terbutaline / Q000627:therapeutic use; D014797:Vital Capacity
D011412:Propanolamines; D001262:Atenolol; D008790:Metoprolol; D013726:Terbutaline