Activation of Ftorafue [R,S-1-(tetrahydro-2-furanyl)-5-fluorouracil] to 5-fluorouracil and gamma-butyrolactone.
D015107:4-Butyrolactone / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D002474:Cell-Free System; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000378:metabolism*; D005663:Furans / Q000378:metabolism*; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D051379:Mice; D008862:Microsomes, Liver / Q000378:metabolism; D011817:Rabbits; D005641:Tegafur / Q000378:metabolism*
D005663:Furans; D005641:Tegafur; D003577:Cytochrome P-450 Enzyme System; D015107:4-Butyrolactone; D005472:Fluorouracil