Organic nitrate therapy in glaucoma.
We determined the effect of organic nitrates on normal volunteers and patients with open-angle and narrow-angle glaucoma. Nitroglycerin lowered intraocular pressure in all patients when administered by the perfusion technique. Isosorbide dinitrate given orally (2 x 40 mg per day) has a potent decreasing effect on intraocular pressure, which cannot be explained by the influence on arterial blood pressure.
D000284:Administration, Oral; D004305:Dose-Response Relationship, Drug; D005901:Glaucoma / Q000188:drug therapy*; D006801:Humans; D007263:Infusions, Parenteral; D007429:Intraocular Pressure / Q000187:drug effects*; D007548:Isosorbide Dinitrate / Q000494:pharmacology / Q000627:therapeutic use*; D005996:Nitroglycerin / Q000494:pharmacology / Q000627:therapeutic use*
D005996:Nitroglycerin; D007548:Isosorbide Dinitrate