Increased resistance to effector cell blockade in antibody-producing cells of NZB mice.
Susceptibility of B lymphocytes fo 'effector cell blockade', i.e. in vitro inactivation of antibody-forming cells by specific antigen, was studied in NZB and C57BL/6 mice. Mice were immunized either with dinitrophenylated dextran (DNP-Dex) or DNP-keyhole limpet hemocyanin (DNP-KLH). It was shown that both direct and indirect anti-DNP plaque-forming cells (PFC) from older NZB mice were less affected by the preincubation with the corresponding antigen than those from age-matched C57BL/6 mice or young NZB mice. The increased resistance of B lymphocytes in aged NZB mice to the effector cell blockade may play a significant role for generation of autoantibody-forming cells in the presence of excess amounts of corresponding antigens.
D000375:Aging; D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology*; D001323:Autoantibodies / Q000096:biosynthesis; D001327:Autoimmune Diseases / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D004136:Dinitrobenzenes / Q000276:immunology; D006462:Hemolytic Plaque Technique; D007111:Immunity, Cellular; D051379:Mice; D008810:Mice, Inbred C57BL; D008814:Mice, Inbred NZB
D001323:Autoantibodies; D004136:Dinitrobenzenes