Platelet transfusion therapy in an alloimmunized patient. The value of crossmatch procedures for donor selection.
A 51-year-old patient with acute myelogenous leukemia, who was alloimmunized to platelets, failed to show adequate platelet increments after receiving transfusions of HLA grade A-identical platelets. Only platelets from an HLA grade B-matching donor gave high increments. Several crossmatching procedures were used to select platelet donors. A correlation was seen between in vitro tests and in vivo response. HLA typing has limitations in the selection of platelet-compatible donors.
D000328:Adult; D001782:Blood Donors; D001788:Blood Grouping and Crossmatching / Q000379:methods; D001792:Blood Platelets / Q000276:immunology; D001803:Blood Transfusion; D005260:Female; D006680:HLA Antigens / Q000276:immunology; D006801:Humans; D007124:Immunoenzyme Techniques; D007518:Isoantibodies / Q000032:analysis*; D015470:Leukemia, Myeloid, Acute / Q000628:therapy*; D010976:Platelet Count; D017713:Platelet Transfusion
D006680:HLA Antigens; D007518:Isoantibodies