Blood group specificity of pancreatic tumor mucin.
N-nitrosobis(2-oxopropyl)amine (BOP)-induced pancreatic adenocarcinomas in Syrian hamsters produce considerable amounts of mucin. The mucin is immunogenic in rabbits and is predominately of A blood group antigenic specificity, as determined by immunodiffusion in agar gel. Indirect immunofluorescence studies with human anti-A typing sera demonstrated bright tumor-mucin fluorescence. The mucin produced by transplantable pancreatic tumors is also of A blood group specificity. Eppley colony Syrian hamsters, randomly examined, demonstrated red cells of blood group O. They lacked the anti-A and anti-B isoagglutinins in their serum. It is emphasized that the antigenic specificity of tumor-mucin in induced pancreatic cancer might be useful for early clinical detection, and perhaps therapy, of the disease.
D000230:Adenocarcinoma / Q000097:blood* / Q000139:chemically induced / Q000378:metabolism; D000373:Agglutinins / Q000032:analysis; D000818:Animals; D001789:Blood Group Antigens / Q000276:immunology*; D006224:Cricetinae; D005455:Fluorescent Antibody Technique; D005779:Immunodiffusion; D008647:Mesocricetus; D009077:Mucins / Q000276:immunology* / Q000378:metabolism; D009602:Nitrosamines; D010190:Pancreatic Neoplasms / Q000097:blood* / Q000139:chemically induced / Q000378:metabolism; D011817:Rabbits
D000373:Agglutinins; D001789:Blood Group Antigens; D009077:Mucins; D009602:Nitrosamines; C013622:nitrosobis(2-oxopropyl)amine