The application of stable isotopes in biomedical research.
Many of the ways in which isotopes are used in biomedical research are reviewed. The use of stable isotopes in stable isotope dilution assays, for metabolite identification and in pharmacokinetic studies, is discussed and relevant examples are given to illustrate the various points made. Isotope effects and their implications for future drug design are considered. Some of the toxicity problems associated with the use of stable isotopes are also considered. Finally, a brief subjective view of possible future advances is made.
D000818:Animals; D001682:Biological Availability; D002247:Carbon Isotopes / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D003903:Deuterium; D006801:Humans; D007201:Indicator Dilution Techniques; D007553:Isotope Labeling; D007554:Isotopes / Q000378:metabolism / Q000633:toxicity; D007700:Kinetics; D009587:Nitrogen Isotopes / Q000378:metabolism; D010103:Oxygen Isotopes / Q000378:metabolism
D002247:Carbon Isotopes; D007554:Isotopes; D009587:Nitrogen Isotopes; D010103:Oxygen Isotopes; D003903:Deuterium