Ir gene testing in H-2 mutants.
Four different C57BL/6 mutants, each with a mutation presumably in the H-2Kb locus, were studied to determine whether the mutations had affected Ir gene function. When tested with the antigens, (TG)-A-L, ovalbumin (OA), and lactic dehydrogenase (LDHB), there was no difference in the antibody response of the mutants when compared to the parental C57BL/6 strain and there was also no difference in the response to the histocompatibility H-Y antigen. The responses to these antigens have been mapped, wholly or partially in the K-IA, IA or IB subregions and therefore the identical response of parent and mutants may provisionally exclude H-2Kb as a site of Ir gene function for the four antigens tested. In addition, the BALB/c-dm2 mutant, a mutation in the H-2Ld locus, gave identical responses to the parental BALB/cKh strain.
D000818:Animals; D000937:Antigen-Antibody Reactions; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics*; D006182:H-Y Antigen / Q000276:immunology; D007770:L-Lactate Dehydrogenase / Q000276:immunology; D051379:Mice; D009154:Mutation; D010047:Ovalbumin / Q000276:immunology
D006183:H-2 Antigens; D006182:H-Y Antigen; D010047:Ovalbumin; D007770:L-Lactate Dehydrogenase