The development of independent secondary ("mirror") discharges in the monkey: failure to replicate earlier findings.
Various factors that might influence the development of the independent secondary focus ("mirror" focus) in the monkey were investigated. Not 1 of 29 monkeys developed independent secondary discharges when we varied: area and length of boundary of the primary epileptogenic agent; ease of passage of agent through pia; nature of chemical agent; mechanical manipulation of homotopic cortex; or site of application of primary agent. The possible reasons for the discrepancy between this negative outcome and our earlier success in obtaining independent foci are discussed.
D000536:Aluminum Hydroxide / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology*; D004292:Dominance, Cerebral / Q000187:drug effects; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D000882:Haplorhini; D008253:Macaca mulatta; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*
D000536:Aluminum Hydroxide