In vitro activity of Ro 13-9904, cefuroxime, cefoxitin, and ampicillin against Neisseria gonorrhoeae.
In vitro susceptibilities of 87 isolates of non-penicillinase-producing Neisseria gonorrhoeae and 8 isolates of penicillinase-producing N. gonorrhoeae to Ro 13-9904, cefuroxime, cefoxitin, and ampicillin were determined. Ro 13-9904 was the most effective of the four drugs, inhibiting growth of both non-penicillinase-producing and penicillinase-producing N. gonorrhoeae.
D000667:Ampicillin / Q000494:pharmacology*; D002440:Cefoxitin / Q000494:pharmacology; D002443:Ceftriaxone; D002444:Cefuroxime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D006801:Humans; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000201:enzymology; D010405:Penicillinase / Q000096:biosynthesis
D002511:Cephalosporins; D002440:Cefoxitin; D002443:Ceftriaxone; D000667:Ampicillin; D010405:Penicillinase; D002444:Cefuroxime