[Comparative study of pirprofen and ketoprofen in the treatment of osteoarthritis of the hip and of the knee].
One hundred and eighty three patients suffering from osteoarthritis of either the hip or the knee were treated during two successive two-week periods by 800 mg/day of pirprofen and 300 mg/day of ketoprofen (two dosages). The order of the treatments was determined randomly. This cross-over was conducted in double blind in 9 rheumatological centers. The efficacy and tolerance of the treatments were evaluated after the first two weeks and at the end of the trial. Pirprofen and ketoprofen showed a definite and comparable efficacy in 70% of patients. The tolerance was acceptable in 86% of patients in the pirprofen groupe and 87% for ketoprofen. Side effects, primarily digestive, were noted with equal frequency (32%). The findings of our study are that a daily dose of 800 mg of pirprofen in the treatment of osteoarthritis of the knee and hip provides an efficacy identical to that of 300 mg/day of ketoprofen with an equally good tolerance.
D000328:Adult; D000368:Aged; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006621:Hip Joint; D006801:Humans; D007660:Ketoprofen / Q000009:adverse effects / Q000627:therapeutic use*; D007719:Knee Joint; D008297:Male; D008875:Middle Aged; D010003:Osteoarthritis / Q000188:drug therapy*; D010666:Phenylpropionates / Q000009:adverse effects / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D010666:Phenylpropionates; D007660:Ketoprofen; C008924:pirprofen
Etude comparative du pirprofène et du kétoprofène dans le traitement de la coxarthrose et de la gonarthrose.