Effects of meclofenamate on the renal actions of mannitol infusion in conscious rabbits. Evidence for osmotic control of renal prostaglandin synthesis?
Experiments in conscious rabbits were designed to determine whether the effects of mannitol on renal blood flow and sodium and water excretion depend on increased renal prostaglandin synthesis. Compared to controls mannitol caused: a) increased glomerular filtration rate, naturesis, and water diuresis, that were unaffected by meclofenamate, b) increased outer cortical flow, that was prevented by meclofenamate, and c) decreased inner cortical flow, that was accentuated by meclofenamate. Thus the diuretic effect of mannitol occurred independently of increases in renal blood flow or prostaglandin synthesis. Changes in renal blood flow distribution with mannitol may be due to altered renal prostaglandin synthesis secondary to changes in tissue osmolarity.
D000818:Animals; D001769:Blood; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006400:Hematocrit; D007668:Kidney / Q000098:blood supply / Q000187:drug effects / Q000502:physiology*; D008353:Mannitol / Q000494:pharmacology*; D008469:Meclofenamic Acid / Q000494:pharmacology*; D009994:Osmolar Concentration; D011453:Prostaglandins / Q000096:biosynthesis*; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D012964:Sodium / Q000097:blood; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D011453:Prostaglandins; D062367:ortho-Aminobenzoates; D008353:Mannitol; D008469:Meclofenamic Acid; D012964:Sodium