Human and murine tumours: changes in cell surface structures coded by the major histocompatibility complex region.
Serological and structural changes of surface markers involved in immune reactions may occur in human and murine tumour systems. Thus nine out of twenty-one human tumour cell lines and SV40-transformed fibroblasts differed from autologous lymphoblastoid cells or fibroblasts in their reactivity with HLA alloantisera. H-2 antigens isolated from the murine tumour cells 6C3HED and TP1422, undergo structural changes. An alien HLA-B7 was detected in sera from two melanoma patients. The serologic activity of H-2 antigens was significantly increased in the serum and ascites fluid of tumour bearing mice. Additionally, human SV40-transformed fibroblasts acquire receptors for monkey red blood cells and the murine lymphosarcoma cells 6C3HED express receptors for sheep red blood cells.
D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology; D005347:Fibroblasts / Q000276:immunology; D005815:Genetic Code; D006183:H-2 Antigens; D000882:Haplorhini; D006801:Humans; D008223:Lymphoma / Q000276:immunology; D008285:Major Histocompatibility Complex; D008545:Melanoma / Q000276:immunology; D051379:Mice; D012397:Rosette Formation; D013205:Staphylococcal Protein A / Q000276:immunology; D000338:beta-Aminoethyl Isothiourea / Q000494:pharmacology
D006183:H-2 Antigens; D013205:Staphylococcal Protein A; D000338:beta-Aminoethyl Isothiourea