The comparative pharmacology of benoxaprofen.
Comparative studies with nonsteroidal antiinflammatory drugs (NSAIDs) have shown benoxaprofen to be moderately active in inhibiting carrageenin-induced pleurisy in rats and cellular migration in vitro. Benoxaprofen was also moderately active in inhibiting developing adjuvant-induced arthritis; however, it exhibited a potent response in established adjuvant arthritis, and it was the only compound tested which showed marked inhibition of the directional movement of mononuclear cells. Unlike other NSAIDs, it was a weak inhibitor of prostaglandin synthetase. The data suggested that there may be mechanisms of antiinflammatory activity which do not relate to inhibition of prostaglandin synthetase.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000188:drug therapy; D001583:Benzoxazoles / Q000378:metabolism / Q000494:pharmacology*; D002351:Carrageenan / Q000037:antagonists & inhibitors; D002448:Cell Adhesion / Q000187:drug effects; D002464:Cell Migration Inhibition; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D016861:Cyclooxygenase Inhibitors; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy; D007962:Leukocytes / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D010998:Pleurisy / Q000188:drug therapy; D011422:Propionates / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats
D000893:Anti-Inflammatory Agents; D001583:Benzoxazoles; D016861:Cyclooxygenase Inhibitors; D011422:Propionates; C011677:benoxaprofen; D002351:Carrageenan