Lysosomal acid hydrolases in developing human brain regions.
beta-D-Glucosidase, beta-D-glucosaminidase, acid phosphatase, and beta-D-galactosidase were monitored in the human foetal brain at different gestational periods. Glucosidase specific activity in all brain regions exhibits two peaks, at 8 g and 32 g foetal weights. Acid phosphatase exhibits very high specific activity in all brain regions at 5 g, but the cerebellar activity forms a peak at 220 g foetal weight, the midbrain at 135 g, and the spinal activity at 760 g. beta-D-Glucosaminidase has a peak at 220 g and 660 g in the midbrain, and beta-D-galactosidase specific activity is highest in the cortex and cerebellum in late gestation (neuronal differentiation phase). The midbrain medulla and the spinal cord show peak activity at 8 g and 220 g foetal weight. The results suggest an inter- and intraregional heterogeneity of acquisition for these enzymes in human brain ontogeny.
D000118:Acetylglucosaminidase / Q000378:metabolism*; D000135:Acid Phosphatase / Q000378:metabolism*; D001835:Body Weight; D001921:Brain / Q000201:enzymology*; D005260:Female; D005333:Fetus / Q000033:anatomy & histology; D005696:Galactosidases / Q000378:metabolism*; D005865:Gestational Age; D005959:Glucosidases / Q000378:metabolism*; D006596:Hexosaminidases / Q000378:metabolism*; D006801:Humans; D008247:Lysosomes / Q000201:enzymology; D011247:Pregnancy; D014018:Tissue Distribution; D001616:beta-Galactosidase / Q000378:metabolism*; D001617:beta-Glucosidase / Q000378:metabolism*
D000135:Acid Phosphatase; D005696:Galactosidases; D005959:Glucosidases; D006596:Hexosaminidases; D001617:beta-Glucosidase; D001616:beta-Galactosidase; D000118:Acetylglucosaminidase