Narcotic-reinforced responding: a rapid evaluation procedure.
Rhesus monkeys were conditioned to lever press for intravenous injections of codeine. The self-injection behavior was brought under the control of a schedule of drug delivery and access to the codeine schedule was made available twice each day. Subsequently, a variety of doses of codeine and saline were compared to the dose used to condition and maintain self-injection responding. Each change in drug condition was maintained for only a single experimental session. The procedure is recommended for rapid evaluation of drugs for their capacity to reinforce self-injection behavior.
D000818:Animals; D003061:Codeine / Q000008:administration & dosage / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D004341:Drug Evaluation; D005260:Female; D000882:Haplorhini; D008253:Macaca mulatta; D008297:Male; D012055:Reinforcement Schedule
D003061:Codeine