[Histophysiologic characteristics of the subcommissural organ during isolated suppression of the functional activity of the zona glomerulosa of the adrenal gland].
The effect of prolonged administration of heparin on the histophysiological characteristics of the subcomissural organ (SCO) of the brain and adrenal glomerular zone (AGZ) was studied in 30 male rats. It was established that heparin inhibits the functional activity of AGZ adrenocorticocytes. This is associated with the lowered content of 3-beta-ol-steroid dehydrogenase, RNA, total protein, and a decrease in the zone width (by 50%). Ependimocytes of brain SCO show an abruptly reduced activity of glutamate dehydrogenase, NAD-dependent alpha-glycerophosphate dehydrogenase, lactate dehydrogenase acid phosphatase, which is evidence of their secretory function inhibition. The changes indicate the presence of the functional relationship between the ependimocytes of brain SCO and AGZ adrenocorticocytes as well as to the participation of brain SCO in AGZ function control.
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D000302:Adrenal Cortex / Q000201:enzymology / Q000502:physiology*; D000818:Animals; D001931:Brain Mapping; D008058:Dihydrolipoamide Dehydrogenase / Q000378:metabolism; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D006493:Heparin / Q000494:pharmacology*; D006651:Histocytochemistry; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D009490:Neurosecretory Systems / Q000502:physiology*; D051381:Rats; D013351:Subcommissural Organ / Q000201:enzymology / Q000502:physiology*; D013385:Succinate Dehydrogenase / Q000378:metabolism
D006493:Heparin; D015096:3-Hydroxysteroid Dehydrogenases; D005993:Glycerolphosphate Dehydrogenase; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; D005969:Glutamate Dehydrogenase; D008058:Dihydrolipoamide Dehydrogenase
Gistofiziologicheskaia kharakteristika subkommural'nogo organa mozga v usloviiakh izolirovannogo podavleniia funktsional'noĭ aktivnosti klubochkovoĭ zony nadpochechnika.