Biological and biochemical properties of a human uveal melanocyte-derived cell line.
A human uveal melanocyte-derived cell line (U1I) is described. The cell line has a doubling time of 27.2 hr, a plating efficiency on plastic surfaces of 10%, and a cloning efficiency in soft agar of < 0.1%. U1I displays marked chromosomal aneuploidy and sensitivity to ultraviolet light. Biochemical studies indicate the presence of tyrosinase, which is stimulated by several compounds, including theophylline, progesterone, and nerve growth factor.
D000293:Adolescent; D002455:Cell Division; D002460:Cell Line; D006728:Hormones / Q000494:pharmacology; D006801:Humans; D007621:Karyotyping; D008297:Male; D008543:Melanins / Q000032:analysis; D008544:Melanocytes; D014442:Monophenol Monooxygenase / Q000378:metabolism; D014466:Ultraviolet Rays; D014602:Uvea; D014780:Viruses / Q000254:growth & development
D006728:Hormones; D008543:Melanins; D014442:Monophenol Monooxygenase