Interaction between fibroblasts, lipoproteins and three antilipoproteins IgA kappa.
Human low density lipoproteins are metabolized by cultured human fibroblasts, through a specific metabolic pathway, which entails the regulation of intracellular cholesterol synthesis. When anti-lipoprotein IgA coming from patients with myeloma, mixed hyperlipidaemia and xanthomatosis were introduced into the system, we observed a decrease of the protein degradation of the LDL molecule, and a disappearance of the regulation of intracellular cholesterol synthesis. In the same system, an anti-lipoprotein IgA from a case of myeloma with mixed hyperlipidaemia, but without xanthomatosis, or control IgG and IgA were inactive and did not modify the LDL pathway.
D000328:Adult; D002478:Cells, Cultured; D002784:Cholesterol / Q000096:biosynthesis; D005260:Female; D005347:Fibroblasts / Q000378:metabolism*; D006801:Humans; D006949:Hyperlipidemias / Q000276:immunology; D007070:Immunoglobulin A / Q000276:immunology*; D007145:Immunoglobulin kappa-Chains / Q000276:immunology; D008077:Lipoproteins, LDL / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D014973:Xanthomatosis / Q000276:immunology
D007070:Immunoglobulin A; D007145:Immunoglobulin kappa-Chains; D008077:Lipoproteins, LDL; D002784:Cholesterol