Ceruletide-assisted examination of the small bowel.
Ceruletide, a decapeptide similar in action to cholecystokinin, was studied in a randomized fashion in 48 patients undergoing routine small bowel examination. Parenteral administration of Ceruletide demonstrated a significantly decreased small bowel transit time (28.8 min) when compared with placebo (67 min) (P less than 0.005). However, this was offset by a diminution in anatomic quality particularly in the distal ileum. A hypotonic action on the duodenual bulb and sweep was observed in 77% of patients after the administration of Ceruletide. This hypotonic effect may prove to be a useful adjunct in the performance of an upper gastrointestinal series.
D000328:Adult; D000368:Aged; D002108:Ceruletide; D055598:Chemical Phenomena; D002621:Chemistry; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D007421:Intestine, Small / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000008:administration & dosage; D010919:Placebos; D011859:Radiography; D013997:Time Factors
D010455:Peptides; D010919:Placebos; D002108:Ceruletide