Altered pharmacodynamics of 1-(2-tetrahydrofuryl)-5-fluorouracil by pretreatment of rats with phenobarbital, indomethacin, diclofenac sodium and carbon tetrachloride.
The disappearance curves of 1-(2-tetrahydrofuryl)-5-fluorouracil (FT-207) from the circulating blood were divided into three different phases, K1, K2 and K3 after its intravenous administration to rats. The relationship between the activity of liver microsomal drug-metabolizing enzymes and K3 values, which were obtained by measuring FT-207 levels between 5 and 24 h after the injection, was observed with phenobarbital, indomethacin, diclofenac sodium and carbon tetrachloride-pretreated rats. Therefore, the blood disappearance rate of K3 was suggested to be an effective parameter for estimating FT-207 metabolism in the liver.
D000818:Animals; D002251:Carbon Tetrachloride / Q000494:pharmacology*; D004008:Diclofenac / Q000494:pharmacology*; D005260:Female; D005472:Fluorouracil / Q000031:analogs & derivatives*; D007213:Indomethacin / Q000494:pharmacology*; D008862:Microsomes, Liver / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology*; D010648:Phenylacetates / Q000494:pharmacology*; D051381:Rats; D005641:Tegafur / Q000097:blood / Q000494:pharmacology*; D013997:Time Factors
D010648:Phenylacetates; D004008:Diclofenac; D005641:Tegafur; D002251:Carbon Tetrachloride; D005472:Fluorouracil; D007213:Indomethacin; D010634:Phenobarbital