A histological, enzymatic and water-electrolyte study of the action of smectite, a mucoprotective clay, on experimental infectious diarrhoea in the rabbit.
The histological, enzymatic and water-electrolyte modifications induced by the administration of smectite, a type of clay reputed to be mucoprotective, have been studied in the rabbit ileal mucosa during infection by saprophytic bacteria and toxigenic E. coli 0128B12. Smectite diminished the bacterial mucolysis and the destruction of the luminal surface membranes of the intestinal epithelium by pathogenic bacteria, as evidenced by the elevation of the disaccharidase and alkaline phosphatase levels. As a result of these effects, the net ion fluxes and net fluid changes favour absorption. These results could account for the mechanism of action of smectite in infectious human diarrhoea.
D000818:Animals; D001826:Body Fluids / Q000502:physiology; D003967:Diarrhea / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D004927:Escherichia coli Infections / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D005765:Gastrointestinal Agents / Q000627:therapeutic use*; D007413:Intestinal Mucosa / Q000187:drug effects* / Q000473:pathology; D008297:Male; D011817:Rabbits; D017640:Silicates; D014882:Water-Electrolyte Balance / Q000187:drug effects
D005765:Gastrointestinal Agents; D017640:Silicates; C033214:Smectite