[Action of epimestrol on pituitary thymidine kinase and gonadotropins in the rat. Comparison with clomiphene and cyclofenil (author's transl)].
The authors have evaluated the influence of epimestrol on several parameters: pituitary thymidine kinase in immature male rats, FSH and LH contents of pituitary and plasma in immature male and mature female rats, oestrous cycle of female rats. The results are compared with those obtained with clomiphene and cyclofenil. Epimestrol, as well as clomiphene, although at a lesser degree modifies gonadotropins levels; in contrast to clomiphene, in the pituitary thymidine kinase test epimestrol shows an oestrogenic potency but not an anti-oestrogenic one. More over it induces a vaginal cells cornification. These data suggest that epimestrol could be efficient in inducing pregnancy.
D000818:Animals; D002996:Clomiphene / Q000494:pharmacology; D003506:Cyclofenil / Q000494:pharmacology; D004836:Epimestrol / Q000494:pharmacology*; D004963:Estrenes / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D007986:Luteinizing Hormone / Q000378:metabolism*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D013937:Thymidine Kinase / Q000378:metabolism*
D004963:Estrenes; D002996:Clomiphene; D004836:Epimestrol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D013937:Thymidine Kinase; D003506:Cyclofenil
Action de l'épimestrol sur la thymidine kinase hypophysaire et sur les gonadotrophines du rat. Comparaison avec le clomifène et le cyclofénil.