Metabolic and physiologic effects of a hunger-inducing injection of insulin.
Rats injected subcutaneously with 5 U/kg of regular insulin increased food intake above control levels in a 2 hr test and showed a median latency to eat of 59 min. One week later, rats were injected again with saline or insulin (5 U/kg), deprived of food and killed 60 +/- 10 min later. Insulin treatment produced a marked reduction in plasma glucose, plasma ketone bodies and liver glycogen, as well as a marked acceleration of gastric emptying. The results indicate that a variety of changes in peripheral metabolism and physiology may underlie the increase in food intake observed after insulin injection and that it is premature to ascribe the hunger-inducing effect of insulin treatment solely to a decline in blood glucose.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004435:Eating / Q000187:drug effects*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005990:Glycerol / Q000097:blood; D006815:Hunger / Q000187:drug effects*; D007328:Insulin / Q000494:pharmacology*; D007657:Ketone Bodies / Q000097:blood; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D009115:Muridae; D011930:Reaction Time / Q000187:drug effects; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D007328:Insulin; D007657:Ketone Bodies; D008112:Liver Glycogen; D014280:Triglycerides; D005990:Glycerol