Small intestinal dipeptidases and disaccharidases in experimental uremia in rats.
Rats were made severely uremic with partial nephrectomy (24-hour creatinine clearance 10% of normal). Jejunal dipeptidase activities (substrates: glycyl-L-leucine, L-alanyl-L-proline, and L-methionyl-L-methionine), disaccharidase activities (maltase, sucrase, trehalase, and lactase) and morphology were studied. A highly significant increase in glycyl-L-leucine and L-methionyl-L-methionine dipeptidases was found in uremic rats compared with controls. Proline dipeptidase activities were unaltered. Disaccharidase activities showed a slight increase in sucrase in uremic rats; otherwise no change was found.
D000818:Animals; D004150:Dipeptidases / Q000378:metabolism*; D004186:Disaccharidases / Q000378:metabolism*; D005998:Glycine / Q000031:analogs & derivatives / Q000378:metabolism; D007413:Intestinal Mucosa / Q000473:pathology; D007421:Intestine, Small / Q000201:enzymology*; D007583:Jejunum / Q000201:enzymology; D007676:Kidney Failure, Chronic / Q000201:enzymology; D008297:Male; D009392:Nephrectomy; D011392:Proline / Q000378:metabolism; D051381:Rats; D013393:Sucrase / Q000378:metabolism; D014198:Trehalase / Q000378:metabolism; D014511:Uremia / Q000201:enzymology*; D000520:alpha-Glucosidases / Q000378:metabolism; D001616:beta-Galactosidase / Q000378:metabolism
D011392:Proline; D004186:Disaccharidases; D000520:alpha-Glucosidases; D001616:beta-Galactosidase; D014198:Trehalase; D013393:Sucrase; D004150:Dipeptidases; C026838:methionyl-L-methionine dipeptidase; C020825:cytosol non-specific dipeptidase; C022449:proline dipeptidase; D005998:Glycine