[Effect of (+)-catechin on protein and basal membrane collagen synthesis in isolated glomeruli of diabetic and nondiabetic rats].
At low concentrations, (+)-catechin leads to an increase and at higher concentrations to an inhibition of protein and basal membrane synthesis in isolated kidney glomeruli of diabetic and non-diabetic rats. The effect shows gradual differences between diabetic and non-diabetic glomeruli. This could be due to the different basal synthetic capacity observed in diabetic and non-diabetic glomeruli.
D000818:Animals; D001485:Basement Membrane / Q000378:metabolism; D001578:Benzopyrans / Q000494:pharmacology*; D002392:Catechin / Q000494:pharmacology*; D003094:Collagen / Q000096:biosynthesis*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D006801:Humans; D006901:Hydroxylysine / Q000378:metabolism; D007678:Kidney Glomerulus / Q000187:drug effects / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism; D008297:Male; D014176:Protein Biosynthesis; D051381:Rats
D001578:Benzopyrans; D006901:Hydroxylysine; D002392:Catechin; D003094:Collagen; D008239:Lysine
Einfluss von (+)-Catechin auf die Protein- und Basalmembrancollagensynthese in isolierten Glomerula diabetischer und nichtdiabetischer Ratten.