Acute and chronic ethanol administration on specific 3H-GABA binding in different rat brain areas.
Acute ethanol treatment produces a significant decrease of specific 3H-GABA binding in cerebellum while no changes were detectable in other brain areas. Scatchard analysis shows a decrease in receptor affinity but not in the number of GABA binding sites. On the other hand, chronic administration of ethanol selectively increases specific 3H-GABA binding in the striatum. Kinetic analysis of these data shows that ethanol chronic administration produces a significant increase in the number of GABA binding sites. These data may be useful for the understanding of clinical pictures following acute and chronic ethanol intoxication.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D051381:Rats; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000431:Ethanol; D005680:gamma-Aminobutyric Acid