Design of cancer chemotherapy: tailored sensitivity assays.
The action of some anti-tumour drugs on normal organ and body growth was studied in rats. The obtained results point to some correlation between the spectrum of the anti-tumour activity of the drugs and the spectrum of their organotoxicity. In some cases, the inhibition of normal growth was also influenced by the loss of appetite and the decrease of food utilization caused by the drugs.
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002699:Chlorambucil / Q000633:toxicity; D008558:Melphalan / Q000633:toxicity; D009588:Nitrogen Mustard Compounds / Q000633:toxicity; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013852:Thiotepa / Q000633:toxicity; D014499:Uracil Mustard / Q000633:toxicity
D000970:Antineoplastic Agents; D009588:Nitrogen Mustard Compounds; D002699:Chlorambucil; D013852:Thiotepa; D008558:Melphalan; D014499:Uracil Mustard