[Current immunologic aspects of kidney transplantation].
The results of clinical kidney transplantation are mainly dependent on immunologic factors many of which are unknown or of unspecified importance. Blood transfusions have a favorable effect on graft prognosis, although our knowledge about optimal transfusion protocols and transfusion-induced mechanisms is still incomplete. The value of HLA-typing is controversial: whereas compatibility of the "classical" HLA-A,B,C antigens improves graft survival only moderately, HLA-DR typing, routinely performed for the last 3 years only, might be of greater importance. In addition, non-HLA systems, such as endothelial/monocytic antigens or the Lewis blood group system, appear to play a role in graft rejection. The individual immune reactivity a recipient to a large extent determines the fate of a graft. The multifactorial dependence of graft prognosis is discussed in this report.
D001787:Blood Group Incompatibility / Q000276:immunology; D001803:Blood Transfusion; D006084:Graft Rejection / Q000187:drug effects; D006085:Graft Survival; D006680:HLA Antigens / Q000276:immunology; D006650:Histocompatibility Testing; D006801:Humans; D007121:Immunocompetence / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007668:Kidney / Q000276:immunology; D016030:Kidney Transplantation; D014019:Tissue Donors; D014181:Transplantation Immunology / Q000187:drug effects
D006680:HLA Antigens; D007166:Immunosuppressive Agents
Aktuelle immunologische Aspekte der Nierentransplantation.