Effect of DDT on cell population growth, cell division, and DNA synthesis in Stylonychia notophora (Stokes).
The effect of DDT on growth and DNA synthesis in Stylonychia notophora was investigated. DDT at a concentration of one ppm did not alter the cell population growth and the morphology of the organisms. However, 50 and 100 ppm DDT inhibited growth and cell division. Continuous treatment of the organisms with 100 ppm DDT produced several nuclear abnormalities. Cells treated with 100 ppm DDT in G1 did not enter S-phase while DNA synthesis was blocked in those cells treated in S-phase.
D002455:Cell Division / Q000187:drug effects; D016798:Ciliophora / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism / Q000648:ultrastructure; D003634:DDT / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis*; D003864:Depression, Chemical; D006801:Humans; D013769:Tetrahymena pyriformis / Q000378:metabolism; D013997:Time Factors
D004247:DNA; D003634:DDT