Restricted expression of a human T cell lineage membrane antigen.
An antiserum raised against human fetal and childhood thymocytes (anti-Thy) and absorbed with peripheral lymphocytes (tonsil) detected an antigen(s) shared by thymocytes, T cell-acute leukemias, activated peripheral T cells and a subset of peripheral T cells. The antigen was expressed by the negative circulating T cell subset after mitogen activation of that separated population. The antigen was shown to be separate from the E rosette receptor, another anti-T cell serum detected antigen, and beta 2-microglobulin; its expression was not related to a particular phase of the cell cycle. The results suggest that the antigen is expressed by T cells only under certain maturational and proliferative conditions.
D000042:Absorption; D000818:Animals; D000954:Antigens, Surface; D000961:Antilymphocyte Serum / Q000494:pharmacology; D002453:Cell Cycle; D002454:Cell Differentiation; D002460:Cell Line; D002648:Child; D005260:Female; D005333:Fetus / Q000276:immunology; D000882:Haplorhini; D006412:Hematopoietic Stem Cells / Q000276:immunology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology; D007951:Leukemia, Myeloid / Q000276:immunology; D015470:Leukemia, Myeloid, Acute / Q000276:immunology; D014066:Palatine Tonsil / Q000276:immunology; D010587:Phagocytosis; D011247:Pregnancy; D011817:Rabbits; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000145:classification / Q000166:cytology* / Q000276:immunology
D000954:Antigens, Surface; D000961:Antilymphocyte Serum