Regulation of serum potassium during insulin-induced hypoglycemia.
Counterregulatory secretion of epinephrine occurs during severe insulin-induced hypoglycemia. Under these conditions (minimal plasma glucose 27.4 +/- 1 mg/dl) the decrease of serum potassium concentration (0.9 mVal/L) is mediated by two mechanisms: insulin-induced (0.48 mVal/L) and epinephrine-induced (0.42 mVal/L) cellular uptake of potassium. Epinephrine-induced serum potassium uptake appears to be more sensitive to beta-adrenoceptor blockade than glucose production. The intensification of insulin-induced hypokalemia by epinephrine is of clinical significance.
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D004311:Double-Blind Method; D004837:Epinephrine / Q000378:metabolism; D006801:Humans; D007003:Hypoglycemia / Q000097:blood* / Q000139:chemically induced; D007328:Insulin / Q000097:blood; D008297:Male; D011188:Potassium / Q000097:blood*; D011433:Propranolol / Q000494:pharmacology
D001786:Blood Glucose; D007328:Insulin; D011433:Propranolol; D011188:Potassium; D004837:Epinephrine