Extramedullary plasmacytoma with gastric and lymph node involvement: an immunological study.
A case of gastric and lymph node extramedullary plasmacytoma is reported in a young Algerian female. Treatment with cyclophosphamide was ineffective, but rubidazone, followed by a maintenance therapy with prednisone, procarbazine, and vinblastine induced a complete remission. Immunofluorescence studies and biosynthesis experiments in vitro showed that the tumor cells produced and secreted IgA-kappa molecules, whereas no monoclonal immunoglobulin could be found in the serum and gastric juice.
D000328:Adult; D005260:Female; D005455:Fluorescent Antibody Technique; D005750:Gastric Juice / Q000276:immunology; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007136:Immunoglobulins / Q000032:analysis; D008207:Lymphatic Metastasis / Q000276:immunology*; D010954:Plasmacytoma / Q000276:immunology*; D013274:Stomach Neoplasms / Q000556:secondary*
D007070:Immunoglobulin A; D007145:Immunoglobulin kappa-Chains; D007136:Immunoglobulins