[Immunological classification of acute lymphoblastic leukemias (ALL) in childhood. Origin and clinical significance of phenotypic variability].
Leucemic cells in 54 children with ALL have been typed immunologically by conventional antisera, monoclonal antibodies and receptor tests as c-ALL (62.5%), T-ALL/NHL (18.5%), B-ALL (1.9%) and AUL (16.6%), respectively. The different subtypes showed a noteworthy heterogeneity in receptor patterns which may reflect an arrest in discrete differentiation stages within the maturation pathway of a lymphoid cell population. The characteristic set of clinical symptoms of T-cell neoplasias could once again be confirmed. Of interest is a clear trend for a less favourable outcome in AUL as compared to c-ALL and in NHL versus ALL as a whole, whereas no difference could be found between T-ALL and non T-ALL during therapy. Immunological typing of ALL is of clinical importance as entities with different biological behaviour and, correspondingly, different therapeutical requirements can be distinguished.
D000293:Adolescent; D000951:Antigens, Neoplasm / Q000235:genetics; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005455:Fluorescent Antibody Technique; D014644:Genetic Variation; D006207:Half-Life; D006801:Humans; D007223:Infant; D007945:Leukemia, Lymphoid / Q000235:genetics / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology; D008297:Male; D010641:Phenotype; D011971:Receptors, Immunologic / Q000235:genetics; D013601:T-Lymphocytes / Q000276:immunology
D000951:Antigens, Neoplasm; D011971:Receptors, Immunologic
Immunologische Klassifizierung der akuten lymphoblastischen Leukämien (ALL) des Kindesalters. Ursprung und klinische Bedeutung der phänotypischen Variabilität.