Effect of ethyl alcohol on maternal and fetal acid-base balance and cardiovascular status in chronic sheep preparations.
Thirteen chronically catheterized pregnant sheep were given intravenous infusions of 10 per cent ethyl alcohol in 5 per cent dextrose solution (15 mg/kg over two hours). Samples of blood from maternal femoral artery, uterine vein, and fetal brachiocephalic artery were drawn at hourly intervals before, during and after the infusions. Plasma was analyzed for alcohol concentration, protein concentration, haematocrit, PCO2 and pH. Maternal and fetal arterial blood pressures were monitored continuously. There were no significant differences between maternal and fetal arterial blood alcohol levels at any sampling interval nor was there any difference in elimination constants. Alcohol infusion did not produce any significant change in plasma protein concentration, haematocrit, PCO2 and pH, and mean arterial blood pressure in either mother or fetus. However, both maternal and fetal heart rate increased significantly following alcohol infusion.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001798:Blood Proteins / Q000032:analysis; D002245:Carbon Dioxide / Q000097:blood; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D005318:Fetal Heart / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006400:Hematocrit; D006439:Hemodynamics / Q000187:drug effects*; D006863:Hydrogen-Ion Concentration; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D012756:Sheep
D001798:Blood Proteins; D002245:Carbon Dioxide; D000431:Ethanol