[Evaluation of the toxicity of meningococcal antigens by the development of paw edema in white mice].
The comparative evaluation of group A meningococcal antigens of different chemical nature (protein, polysaccharide, lipopolysaccharide and complex fraction) was made by the method of paw edema. The preparations were introduced in a dose of 100 micrograms/0.05 ml. The dynamics of the development of edema was observed. The chemical nature of the injected antigen was found to be related to changes in the character of edema in time: edema reached its maximum 3 hours after the injection of protein and 48 hour after the injection of lipopolysaccharide. The animals showed practically no reaction to polysaccharide.
D000818:Animals; D000942:Antigens, Bacterial / Q000633:toxicity*; D001426:Bacterial Proteins / Q000633:toxicity; D001427:Bacterial Toxins; D002463:Cell Membrane Permeability; D004487:Edema / Q000139:chemically induced*; D051379:Mice; D009345:Neisseria meningitidis / Q000032:analysis / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000633:toxicity
D000942:Antigens, Bacterial; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D011135:Polysaccharides, Bacterial
Otsenka toksichnosti meningokokkovykh antigenov po razvitiiu oteka lap belykh mysheĭ.