[Streptococcal A-induced polyclonal T-cell activation leads to a secondary functional activation of human B-cells].
Human lymphocytes are activated by cell walls or cytoplasma membranes of A-streptococci. Even in health human volunteers lymphocyte proliferation, lymphokine production and immunoglobulin synthesis is induced by high concentrations of streptococcal cell components following a pattern of polyclonal lymphocyte activation. We were interested in the special cellular requirements in this particular model. In cell separation and restitution experiments the observed B-cell activation was identified as the consequence of a primary monocyte-dependent polyclonal T-cell activation. Furthermore, lymphocyte proliferation and lymphokine production proved to be a monocyte- and T-cell-dependent process as well. Thus, lymphocyte activation induced by somatic streptococcal structures in humans depends upon a pattern of cell cooperation of mononuclear subpopulations well-known in a series of classical mitogen-induced lymphocyte activation.
D000942:Antigens, Bacterial / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D002999:Clone Cells / Q000276:immunology; D006462:Hemolytic Plaque Technique; D006801:Humans; D007111:Immunity, Cellular; D007961:Leukocyte Migration-Inhibitory Factors / Q000096:biosynthesis; D008213:Lymphocyte Activation; D008211:Lymphocyte Cooperation; D009000:Monocytes / Q000276:immunology; D012213:Rheumatic Fever / Q000276:immunology; D013297:Streptococcus pyogenes / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000942:Antigens, Bacterial; D007961:Leukocyte Migration-Inhibitory Factors
Die A-Streptokokken-induzierte polyklonale T-Zellaktivierung führt zu einer sekundären funktionellen Aktivierung von humanen B-Zellen.