Prehepatic hyperalimentation.
A technique for prehepatic infusion of parenteral nutrients is described. Portal vein hyperalimentation allows hepatic modification and control of the infused nutrients before delivery of these substances into the general circulation and theoretically should reduce the incidence of metabolic complications of hyperalimentation. The clinical experience with prehepatic infusions is reported and the metabolic investigations are described. Transumbilical catheters provided prehepatic delivery of parenteral nutrients for 1 month after esophagogastrectomy for esophageal malignancy without serious infection or portal vein thrombosis. Close surveillance of blood glucose and serum osmolarity demonstrated metabolic stability during the infusion period. Nitrogen balance studies showed better nitrogen economy than is achieved by infusion of similar solutions into the central systemic circulation. Indirect calorimetry indicated that the nitrogen used for production of energy was less than the amount supplied by prehepatic infusions. The same basic liver function abnormalities encountered with systemic infusion of hyperalimentation solutions were noted. The patients gained weight after esophagogastrectomy and did not experience the attrition from malnutrition which usually occurs in the first several months after esophageal resection.
D000596:Amino Acids / Q000008:administration & dosage / Q000378:metabolism; D001786:Blood Glucose / Q000032:analysis; D002153:Calorimetry, Indirect; D002277:Carcinoma / Q000628:therapy; D002404:Catheterization / Q000009:adverse effects; D004938:Esophageal Neoplasms / Q000628:therapy; D005947:Glucose / Q000008:administration & dosage; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000502:physiology; D009584:Nitrogen / Q000378:metabolism; D010288:Parenteral Nutrition / Q000379:methods*; D010289:Parenteral Nutrition, Total / Q000379:methods*; D011169:Portal Vein; D014471:Umbilical Veins
D000596:Amino Acids; D001786:Blood Glucose; D005947:Glucose; D009584:Nitrogen