Evidence for the role of noradrenaline in some effects of quipazine.
In mice, quipazine has shown several behavioral effects: It antagonizes hypothermia induced by a high dose of apomorphine without altering climbing or stereotyped behavior; it antagonizes oxotremorine-induced hypothermia without altering tremors or peripheral signs; and it increases the toxicity of yohimbine. These three responses are considered to be predictive of an antidepressive action; in these three tests the effects of quipazine are inhibited by D,L-propranolol but not by D-propranolol or methysergide. Quipazine, in mice pretreated with pargyline, induced head twitches which were inhibited by methysergide but not by D,L-propranolol. Quipazine, in addition to its well-known serotonergic effects, seems to have beta-adrenergic properties which should be kept in mind when this drug is used as a pharmacological tool and which suggest that the beta-adrenergic system is implied in depression.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D006801:Humans; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D051379:Mice; D009638:Norepinephrine / Q000502:physiology*; D011433:Propranolol / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology*; D011814:Quipazine / Q000494:pharmacology*; D012110:Reserpine / Q000494:pharmacology; D013239:Stereotyped Behavior / Q000187:drug effects; D015016:Yohimbine / Q000494:pharmacology
D011804:Quinolines; D015016:Yohimbine; D011814:Quipazine; D012110:Reserpine; D011433:Propranolol; D001058:Apomorphine; D009638:Norepinephrine; D008784:Methysergide