Chronic obstructive pulmonary disease (COPD): effects of bronchodilator drugs on normal and affected horses.
The effects of the bronchodilator drugs, atropine, isoprenaline and terbutaline, on normal horses and on horses affected with chronic obstructive pulmonary disease (COPD), were assessed by pulmonary function tests and clinical examination. Normal horses were not affected but COPD horses responded by a marked decrease in intrathoracic pressure, a decrease in respiratory rate, an initial decrease followed by an increase in arterial oxygen partial pressure and clinical improvement after treatment with all 3 drugs. These changes were temporary.
D000818:Animals; D001285:Atropine / Q000494:pharmacology / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D001993:Bronchodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002245:Carbon Dioxide; D006734:Horse Diseases / Q000188:drug therapy*; D006736:Horses; D007545:Isoproterenol / Q000494:pharmacology / Q000627:therapeutic use; D008173:Lung Diseases, Obstructive / Q000188:drug therapy / Q000662:veterinary*; D010100:Oxygen; D010313:Partial Pressure; D011312:Pressure; D012123:Pulmonary Ventilation / Q000187:drug effects; D013726:Terbutaline / Q000494:pharmacology / Q000627:therapeutic use
D001993:Bronchodilator Agents; D002245:Carbon Dioxide; D001285:Atropine; D007545:Isoproterenol; D013726:Terbutaline; D010100:Oxygen