Hormonal and metabolic effects of intravenous infusion of prostacyclin in healthy women.
To study the hormonal and metabolic effects of prostacyclin (PGI2), 6 healthy women were infused iv with PGI2 (1, 2, 4, and 8 ng/kg/min. each for 20 min) dissolved in glycine buffer, or with glycine buffer only. Serial blood samples collected before, during and after the infusion were assayed for FSH, LH, prolactin, growth hormone, thyrotrophin, oestradiol, progesterone, testosterone, cortisol, thyroxine, triiodothyronine, renin, aldosterone, glucose, insulin, glucagon, cholesterol, high density lipoprotein-cholesterol, triglycerides, alkaline phosphatase, alanine and aspartate aminotransferases, bilirubin, sodium, potassium, chloride, calcium, inorganic phosphorous, creatinine and uric acid. PGI2 infusions were accompanied by increased levels of prolactin, growth hormone and cortisol, probably due to the stressful side-effects during PGI2 infusion. In addition, plasma renin activity, glucagon and blood glucose increased, whereas the other variables measured did not change. These PGI2-effects should be kept in mind, when PGI2 is used in clinical practice.
D000293:Adolescent; D000328:Adult; D011464:Epoprostenol / Q000494:pharmacology*; D005260:Female; D005934:Glucagon / Q000097:blood; D004763:Glucagon-Like Peptides / Q000097:blood; D012739:Gonadal Steroid Hormones / Q000097:blood*; D006801:Humans; D007263:Infusions, Parenteral; D007328:Insulin / Q000097:blood; D010907:Pituitary Hormones / Q000097:blood*; D011453:Prostaglandins / Q000494:pharmacology*; D012083:Renin / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood*
D012739:Gonadal Steroid Hormones; D007328:Insulin; D010907:Pituitary Hormones; D011453:Prostaglandins; D013963:Thyroid Hormones; D004763:Glucagon-Like Peptides; D005934:Glucagon; D011464:Epoprostenol; D012083:Renin