Relationships between Ascaris infection and growth of malnourished preschool children in Kenya.
A longitudinal study in Ascaris-infected and noninfected children was conducted in two Kenyan villages. Anthropometric, clinical, and stool exams were performed three times at 14-week intervals. All children received an anthelmintic drug (levamisole) at the second examination. In the 14 weeks before deworming, children with Ascaris (n = 61) did not differ from controls (n = 125) in percentage expected weight gain. In the 14 weeks after deworming, previously infected children showed higher percentage expected weight gain than controls. Before deworming, there was a statistically significant (P less than 0.0005) decrease in triceps skinfold thickness in Ascaris-infected children versus controls. After deworming, skinfold increased significantly (P less than 0.0005) in previously infected children versus controls. Multiple regression analysis showed that Ascaris infection was by far the most important variable of those studied explaining decrease in skinfold thickness before and increase after deworming. It appears that even light Ascaris infections might adversely influence nutritional status, and deworming might enhance growth.
D000886:Anthropometry; D001196:Ascariasis / Q000150:complications* / Q000188:drug therapy; D001827:Body Height; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D006128:Growth; D006801:Humans; D007223:Infant; D007630:Kenya; D007978:Levamisole / Q000627:therapeutic use; D008954:Models, Biological; D010270:Parasite Egg Count; D011502:Protein-Energy Malnutrition / Q000150:complications*; D012885:Skinfold Thickness
D007978:Levamisole