Quintuplet pregnancies.
Five quintuplet pregnancies, following induction of ovulation with clomiphene and HMG-HCG, are the subject of this communication. In 3 women, pregnancy was associated with ovarian overstimulation, and two patients required emergency surgery because of torsion of an ovarian cyst. Two women aborted in mid-trimester, while the other 3 delivered by cesarean section at 33-35 wk gestation. 15 babies were born, weighing 700-2200 g. 8 infants suffered from respiratory distress syndrome and 5 babies were born with correctable malformations. 13 newborns survived, and all are mentally and physically well-developed. Four of the 5 women conceived again. The management of the patients during multiple gestation and the outcome of pregnancy are discussed.
D002996:Clomiphene / Q000009:adverse effects / Q000627:therapeutic use; D005260:Female; D006065:Gonadotropins, Pituitary / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000209:etiology; D008596:Menotropins / Q000009:adverse effects / Q000627:therapeutic use; D010060:Ovulation / Q000187:drug effects; D010062:Ovulation Induction; D011247:Pregnancy; D011255:Pregnancy Maintenance; D011272:Pregnancy, Multiple; D011811:Quintuplets; D012744:Sex Ratio
D006065:Gonadotropins, Pituitary; D002996:Clomiphene; D008596:Menotropins