[Role of prolactin in the development of mammary gland tumors induced by dimethylbenzanthracene].
The action of high prolactin content on dimethylbenzanthracene-induced mammary carcinoma was studied in rats with varying bodily content of estrogens. It was found that the high content of endogenous prolactin in rats provoked by ligation of the hypophyseal peduncle or aminazin injection stimulates the development of dimethylbenzanthracene-induced carcinoma even in the presence of the lowered estrogenic content. Ovarectomy dramatically reduced the effect of hypophyseal peduncle ligation. Combined action of estrogens and prolactin is conducive to the development of hormone dependent mammary carcinoma. The role of hormones in the pathogenesis of mammary carcinoma and approaches to its prevention and choice of an adequate treatment are discussed.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002369:Castration; D002746:Chlorpromazine; D003043:Cocarcinogenesis; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000209:etiology*; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism*; D051381:Rats
D015127:9,10-Dimethyl-1,2-benzanthracene; D011388:Prolactin; D002746:Chlorpromazine
Rol' prolaktina v razvitii opukholeĭ molochnoĭ zhelezy, indutsirovannykh dimetilbenzantratsenom.