Urinary excretion of beta-hexosaminidase in different forms of proteinuria.
The urinary excretion of beta-hexosaminidase was studied in different forms of proteinuria. Patients with tubular proteinuria showed a very large increase in beta-hexosaminidase only in the acute stage of the renal disease, while patients with chronic tubular dysfunction did not show any greater degree of beta-hexosaminidase excretion. The same findings were noted in glomerular disease, in which patients with a very high degree of disease activity showed a marked increase in enzyme excretion. There was a good correlation between enzyme excretion and level of proteinuria. In Bence-Jones proteinuria it seems possible to determine the grade of renal injury caused by the light chain.
D058186:Acute Kidney Injury / Q000201:enzymology; D000293:Adolescent; D000328:Adult; D000368:Aged; D001536:Bence Jones Protein / Q000652:urine; D005260:Female; D005921:Glomerulonephritis / Q000201:enzymology; D006596:Hexosaminidases / Q000652:urine*; D006801:Humans; D007674:Kidney Diseases / Q000150:complications / Q000201:enzymology*; D007684:Kidney Tubules / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000201:enzymology; D009393:Nephritis / Q000201:enzymology; D011507:Proteinuria / Q000150:complications / Q000201:enzymology*; D008258:Waldenstrom Macroglobulinemia / Q000201:enzymology
D001536:Bence Jones Protein; D006596:Hexosaminidases