HLA typing in non-Hodgkin's lymphomas. Comparative study in Caucasoids, Mexican-Americans and Negroids.
Over 200 cases of non-Hodgkin's lymphoma were typed for HLA-A, B, C and DR antigens, and typing was correlated with the morphologic diagnosis according to the Lukes-Collins classification system of non-Hodgkin's lymphomas. Three major racial groups were represented: Caucasoids, Mexican-Americans and Negroids. Significant associations were observed between HLA-AW33 and Caucasoid B-cell lymphomas, and for HLA AW24, HLA-B37 and HLA-B40 and B cell lymphomas in Negroids. No significant correlations were found within the Mexican-American patient population. The number of T cell lymphomas was insufficient to draw any conclusions. The DR antigens were not significantly associated with any of the diagnostic subgroups.
D001402:B-Lymphocytes / Q000276:immunology; D044383:Black People; D003601:Cytotoxicity Tests, Immunologic; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics / Q000276:immunology; D015235:HLA-B Antigens; D006630:Hispanic or Latino; D006801:Humans; D008223:Lymphoma / Q000145:classification / Q000276:immunology*; D008224:Lymphoma, Follicular / Q000276:immunology; D008800:Mexico / Q000208:ethnology; D044465:White People
D006680:HLA Antigens; D015235:HLA-B Antigens