Characterization of a novel human pre-B leukemia cell line.
The derivation of a new human pre-B cell line from the leukocytes of a girl in the leukemic phase of lymphoblastic lymphoma is reported. Cells of this line, termed SMS-SB, synthesized mu but not light chains. These mu-chains were found only in the cytoplasm and were not secreted. SMS-SB cells bore HLA-DR determinants. They did not express the common ALL antigen or terminal deoxynucleotidyl transferase and, therefore, differed from previously described human pre-B leukemia cell lines. SMS-SB cells resembled certain Abelson leukemia virus-transformed mouse bone marrow cells. Except for the lack of formed mouse bone marrow cells. Except for the lack of mu secretion, the phenotype of SMS-SB cells was the same as the major subpopulation of marrow pre-B cells.
D000293:Adolescent; D001402:B-Lymphocytes / Q000276:immunology*; D002454:Cell Differentiation; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology; D002471:Cell Transformation, Neoplastic; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007148:Immunoglobulin mu-Chains / Q000096:biosynthesis; D007621:Karyotyping; D008223:Lymphoma / Q000276:immunology* / Q000382:microbiology; D013601:T-Lymphocytes / Q000166:cytology
D007148:Immunoglobulin mu-Chains