Cell-mediated anti-tumor response in the RLmale 1 system. II. Control of the T killer cells by an H-2-linked Ir gene interfering with non-H-2 factors.
The generation of cytolytic T lymphocytes (CTL) during the immune response directed against the syngeneic X-ray-induced BALB/c RLmale 1 leukemia has been described previously: T killer cells react with a tumor antigen of RLmale 1 cells, and the H-2Dd molecules of the target cells play some role in the interaction. The study of anti-RLmale 1 responses of [(C57BL/6 x BALB/c) x BALB/c] mice shows that the major histocompatibility complex controls the anti-RLmale 1 CTL reaction at a second level, through an Ir gene, with dominant responsiveness, probably mapping to the right of I-B and controlling the high or low-CTL responder phenotype. Another non-H-2 associated gene interferes with the H-2 linked Ir gene, a responder allele at the non-H-2 locus, being necessary for the expression of the high-responder phenotype at the Ir gene locus.
D000818:Animals; D003433:Crosses, Genetic; D003602:Cytotoxicity, Immunologic; D005260:Female; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D006183:H-2 Antigens; D006824:Hybridization, Genetic; D007111:Immunity, Cellular; D007942:Leukemia, Experimental / Q000276:immunology*; D008297:Male; D051379:Mice; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000276:immunology*
D006183:H-2 Antigens