Prolongation of islet xenograft survival without continuous immunosuppression.
The survival of isolated rat islets transplanted into diabetic mice was prolonged markedly by maintaining the rat islets in vitro at 24 degrees C for 7 days before transplantation and administering to the recipients a single injection of antiserum to mouse and rat lymphocytes shortly before transplantation.
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002470:Cell Survival; D002478:Cells, Cultured; D003921:Diabetes Mellitus, Experimental / Q000628:therapy*; D007165:Immunosuppression Therapy; D016381:Islets of Langerhans Transplantation; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D051381:Rats; D014183:Transplantation, Heterologous; D014185:Transplantation, Isogeneic
D001786:Blood Glucose