Assessment of some genetic non-MHC differences with GVHR-induced anti-listeria activity of macrophages.
Parental cells A injected into (A X B)F1 heterozygotes induce a graft-versus-host reaction (GVHR) which induces systemic activation of anti-Listeria-bactericidal capacity of host macrophages. When donor lymphocytes differ from parent A with respect to various non-H-2 genetic markers, they may or may not be able to induce a GVHR. Some, but not all, known and some unknown non-H-2 differences can be assessed by this method within nine to 12 days. The method is described and some of the following non-H-2 differences are shown to influence GVHR-induced macrophage activation: male H-Y antigen, H-3 or H-4 (but not H-1 or H-9), and as yet underlined differences that apparently exist between mouse substrains of the same or similar designation, but obtained from different breeding establishments.
D000818:Animals; D005260:Female; D006087:Graft vs Host Reaction; D006182:H-Y Antigen / Q000235:genetics; D008088:Listeriosis / Q000235:genetics / Q000276:immunology*; D008262:Macrophage Activation; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008912:Minor Histocompatibility Loci; D016038:Skin Transplantation; D013045:Species Specificity
D006182:H-Y Antigen