Isoproterenol-induced intramembrane particle aggregation and water flux in toad epidermis.
Stimulation of toad skin with isproterenol resulted in a dramatic increase in water flow, and in the appearance of aggregates of intramembrane particles in the apical membrane of granular cells of the replacement layer, just beneath the stratum corneum. This membrane structural modification appears to be a general prerequisite for the change in water permeability of vasopressin-sensitive epithelia.
D000818:Animals; D002024:Bufo marinus; D002462:Cell Membrane / Q000648:ultrastructure; D002463:Cell Membrane Permeability; D004817:Epidermis / Q000187:drug effects / Q000378:metabolism*; D007545:Isoproterenol / Q000494:pharmacology; D014867:Water / Q000378:metabolism*
D014867:Water; D007545:Isoproterenol