Parenteral immunization with live respiratory syncytial virus is blocked in seropositive cotton rats.
Seropositive cotton rats cannot be immunized by intramuscular inoculation of live respiratory syncytial virus. Passively administered antiserum was shown to effect the immunosuppression. By contrast, the presence of serum antibody did not block immunization by the intranasal route.
D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000276:immunology*; D003411:Arvicolinae; D007108:Immune Tolerance; D007116:Immunization, Passive; D008168:Lung / Q000382:microbiology; D009666:Nose / Q000382:microbiology; D012136:Respiratory Syncytial Viruses / Q000254:growth & development / Q000276:immunology*; D010253:Respirovirus Infections / Q000276:immunology*; D014611:Vaccination; D014765:Viral Vaccines / Q000276:immunology
D000914:Antibodies, Viral; D014765:Viral Vaccines