Biochemical changes in neurosurgical patients under critical care treated with mannitol.
A Study was carried out on ten patients undergoing operations for brain tumors, who were treated with mannitol solutions. This caused a significant depletion of serum sodium ion and in an increase of discriminate osmolality (to 60 mosM/kg H2O). A hypothesis about the particular biochemical mechanism, involving the electrolyte and water distribution, is presented.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D001784:Blood Gas Analysis; D001932:Brain Neoplasms / Q000378:metabolism / Q000601:surgery*; D006801:Humans; D008353:Mannitol / Q000627:therapeutic use*; D009994:Osmolar Concentration; D011188:Potassium / Q000378:metabolism; D011292:Premedication; D012964:Sodium / Q000378:metabolism
D008353:Mannitol; D012964:Sodium; D011188:Potassium