Chemical sclerosis of the adrenal medulla with sodium salyclate (2.5 M) - histopathologic, histoenzymatic, electron microscopic and biochemical studies.
The selective inhibitory effect of sodium salicylate (2.5 M) on the adrenal medulla was investigated histopathologically, histoenzymatically, electron microscopically and biochemically. It was proved that the different behaviour of nicotinamide-adenine dinucleotide (NAD) and nicotinamide-adenine dinucleotide phosphate (NADP) linked dehydrogenases under the action of sodium salicylate can account for the survival of cortical cells, while the medullar ones are necrosed.
D000302:Adrenal Cortex / Q000187:drug effects; D000311:Adrenal Glands / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D000313:Adrenal Medulla / Q000187:drug effects; D000429:Alcohol Oxidoreductases / Q000378:metabolism; D000818:Animals; D004285:Dogs; D006651:Histocytochemistry; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D009336:Necrosis; D051381:Rats; D012598:Sclerosis; D012980:Sodium Salicylate / Q000494:pharmacology*
D009243:NAD; D009249:NADP; D000429:Alcohol Oxidoreductases; D012980:Sodium Salicylate