Microplate leukocyte adherence inhibition assay in pancreatic cancer. Effect of chemotherapy on the specific antitumor response.
This study evaluated the effect of adriamycin and 5-fluorouracil (5-FU) on the host's tumor specific immune response monitored by a microplate leukocyte adherence inhibition assay (LAI) in patients with pancreatic ductal adenocarcinoma. Sixteen previously LAI positive patients were treated with adriamycin. The previously positive LAI responses were abrogated in 11 of the 16 patients. This effect of adriamycin on the hosts' tumor specific immune response lasted for a period of 4 weeks following therapy. Seventeen LAI reactive patients were treated with 5-FU. In contrast to the effect of adriamycin, 13 of these 17 patients remained LAI reactive following administration of 5-FU.
D004317:Doxorubicin / Q000494:pharmacology*; D005472:Fluorouracil / Q000494:pharmacology*; D006801:Humans; D007113:Immunity, Innate / Q000187:drug effects; D007158:Immunologic Techniques; D007957:Leukocyte Adherence Inhibition Test; D010190:Pancreatic Neoplasms / Q000188:drug therapy / Q000276:immunology*
D004317:Doxorubicin; D005472:Fluorouracil