[Effect of preimmunization with its carrier on the cellular secretion of IgM anti-TNP antibodies].
The secretion rate of anti-TNP IgM antibodies has been assessed on spleen cells from unprimed or HRBC-primed mice following immunization with TNP-HRBC. Measurement of the antibodies secretion rate was performed by the hemolytic plaque inhibition assay. HRBC-priming induced greater numbers of anti-TNP PFC/spleen but had no effect on the antibody secretion rate and on its heterogeneity. It is noteworthy that both secretion rate and its heterogeneity were found to oscillate with time after immunization.
D000818:Animals; D000917:Antibody Formation; D006241:Haptens / Q000276:immunology*; D006462:Hemolytic Plaque Technique; D007114:Immunization; D007075:Immunoglobulin M / Q000276:immunology; D008297:Male; D051379:Mice; D009578:Nitrobenzenes / Q000276:immunology*; D013154:Spleen / Q000276:immunology; D013997:Time Factors; D014301:Trinitrobenzenes / Q000276:immunology*
D006241:Haptens; D007075:Immunoglobulin M; D009578:Nitrobenzenes; D014301:Trinitrobenzenes
Effetto della preimmunizzazione con il carrier sulla secrezione cellulare di anticorpi IgM anti TNP.