Cyclosporin A as a tool for experimental and clinical transplantation.
Cyclosporin A is a new agent that is immunosuppressive, lacks myelotoxicity and seems capable of inducing specific transplantation tolerance. It prevents the development of cytotoxic effector T-cells by interfering with the complex interleukin-2 system yet permits the establishment of suppressor T-cells in antigen driven proliferation systems in vitro, thus possibly inducing operational tolerance. Although preclinical transplant studies as well as non-controlled clinical transplant studies have shown impressive results, controlled clinical studies could only in a few situations demonstrate the superiority of Cyclosporin A over conventional immunosuppressive regimens. Further studies are needed to establish the role of this new drug in experimental and clinical transplantation.
D000818:Animals; D016026:Bone Marrow Transplantation; D003524:Cyclosporins / Q000494:pharmacology*; D006087:Graft vs Host Reaction / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents; D014180:Transplantation / Q000379:methods*; D014184:Transplantation, Homologous
D003524:Cyclosporins; D007166:Immunosuppressive Agents