Coexistence of a circulating IgG-albumin complex and a gamma heavy chain in the same patient.
A patient with an IgG-albumin complex and a gamma heavy chain in his serum was studied by crossed immunoelectrophoresis. The IgG-albumin complex was not dissociated after incubation with 2-mercaptoethanol but it was after incubation with sodium dodecyl sulfate. Evidence was obtained that the IgG and albumin were held together by noncovalent bonds, possibly due to an antigen-antibody reaction.
D000936:Antigen-Antibody Complex; D003920:Diabetes Mellitus / Q000276:immunology*; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D007074:Immunoglobulin G / Q000378:metabolism*; D007143:Immunoglobulin Heavy Chains / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000378:metabolism*
D000936:Antigen-Antibody Complex; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D012709:Serum Albumin