Ocular penetration of cefazolin in humans and rabbits after subconjunctival injection.
We determined the clinical potential of cefazolin by assaying aqueous samples for levels of aqueous penetration of cefazolin in humans and rabbits after subconjunctival injection. Cefazolin is a broad spectrum antiotic that appears to penetrate aqueous humor in bactericidal concentrations after subconjunctival injection and may serve as a useful alternative in patients sensitive to other antibiotics.
D000818:Animals; D001082:Aqueous Humor / Q000378:metabolism*; D001412:Bacillus subtilis / Q000187:drug effects; D001681:Biological Assay; D002437:Cefazolin / Q000008:administration & dosage / Q000378:metabolism*; D003228:Conjunctiva; D006801:Humans; D007267:Injections; D011817:Rabbits; D013997:Time Factors
D002437:Cefazolin