Differences in the susceptibility of various aldose reductases to inhibition. II.
The susceptibility of human lens aldose reductase (HLAR), human placental aldose reductase (HPAR), and rat lens aldose reductase (RLAR) to inhibition by 10 structurally diverse inhibitors is compared. Significant differences in the susceptibility of these enzymes was observed; however, no trends could be predicted. In general, HPAR appeared to be less susceptible to inhibition than either HLAR or RLAR, with the susceptibility of HLAR being more similar to RLAR than to HPAR. These findings indicate that the evaluation of aldose reductase inhibitors for potential clinical use may require the use of human aldose reductase from the appropriate target tissue.
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002386:Cataract / Q000201:enzymology; D002867:Chromones / Q000494:pharmacology; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D048289:Imidazolidines; D007546:Isoquinolines / Q000494:pharmacology; D007908:Lens, Crystalline / Q000201:enzymology* / Q000378:metabolism; D010920:Placenta / Q000201:enzymology; D011247:Pregnancy; D011794:Quercetin / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D013401:Sugar Alcohol Dehydrogenases / Q000037:antagonists & inhibitors*; D013402:Sugar Alcohols / Q000378:metabolism
D002867:Chromones; D007093:Imidazoles; D048289:Imidazolidines; D007546:Isoquinolines; D013402:Sugar Alcohols; C026489:ethyl 7-hydroxy-4-oxo-4H-chromen-2-carboxylate; C012526:quercitrin; C026488:7-hydroxy-4-oxo-4H-chromen-2-carboxylic acid; C016212:alrestatin; D011794:Quercetin; D013401:Sugar Alcohol Dehydrogenases; D000449:Aldehyde Reductase; C026411:sorbinil