[Effect of protein synthesis inhibitors on the vicasol-induced change in the content of the thermostable antifactor Xa in the blood serum].
Content of a thermostable inhibitor of thrombinogenesis (antifactor Xa) was decreased in blood serum after administration of pellentan. Subsequent treatment with vicasol normalized at the accelerated rate the antifactor Xa content in blood serum. Administration of the inhibitors of protein synthesis (vincrystine, actinomycin D, toyomycin, tetracycline--inhibitors of RNA polymerase, elongation, posttranscriptional conversions of mRNA and of translation processes, respectively (did not alter distinctly the vicasol effect--decrease in antifactor Xa content of blood serum. Vitamin K appears to participate in formation of the active molecule of the inhibitor of thrombinogenesis at the postribosomal step as shown in study of several other blood plasma procoagulants.
D000818:Animals; D000991:Antithrombins / Q000032:analysis*; D014128:Chromomycin A3 / Q000494:pharmacology; D003609:Dactinomycin / Q000494:pharmacology; D004355:Drug Stability; D005017:Ethyl Biscoumacetate / Q000008:administration & dosage; D005170:Factor X / Q000032:analysis / Q000037:antagonists & inhibitors*; D015951:Factor Xa; D051381:Rats; D013696:Temperature; D013752:Tetracycline / Q000494:pharmacology; D013997:Time Factors; D014750:Vincristine / Q000494:pharmacology; D014812:Vitamin K / Q000031:analogs & derivatives* / Q000494:pharmacology; D024483:Vitamin K 3
D000991:Antithrombins; D005017:Ethyl Biscoumacetate; D014812:Vitamin K; D003609:Dactinomycin; D014750:Vincristine; D024483:Vitamin K 3; D005170:Factor X; D014128:Chromomycin A3; D015951:Factor Xa; D013752:Tetracycline
Vliianie ingibitorov sinteza belkov na vyzyvaemoe vikasolom izmenenie soderzhaniia termostabil'nogo antifaktora Xa v syvorotke krovi.