Synthesis of 4-(3-benzazolymethyl)aminodiphenyl ethers and other related products as potential antimicrobial agents.
4-Aminodiphenyl ethers (2) obtained by reducing the corresponding nitro analogue (1), have been incorporated into benzazoles, phthalimides and 4-quinazolone in the presence of 40% formalin to furnish a series of 4-(3-benzazolymethyl)aminodiphenyl ethers (3) under the conditions of the Mannich reaction. In an alternate procedure, 3 were obtained on refluxing the N-hydroxymethyl derivatives of benzazoles etc. with 2 in methanol. A few amine exchange reactions were also performed and the stability of a few representative compounds was studied in different acidic media. The antibacterial spectrum of all the synthesized compounds was determined against Bacillus subtilis as well as Bacillus pumilus by the agar diffusion technique.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D001407:Bacillus / Q000187:drug effects; D001412:Bacillus subtilis / Q000187:drug effects; D001419:Bacteria / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D010647:Phenyl Ethers / Q000138:chemical synthesis* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D010647:Phenyl Ethers