Clinical trials of amodiaquine in onchocerciasis.
Twenty onchocerciasis patients from the rain-forest zone of Western Nigeria were treated with amodiaquine in total dosages ranging from 22 to 68 mg/kg of body weight given over 2-9 days. There was no activity against either the microfilariae or adult forms of Onchocerca volvulus. It is concluded that the drug, which was poorly tolerated by 12 patients, is ineffective against human onchocerciasis.
D000328:Adult; D000655:Amodiaquine / Q000008:administration & dosage* / Q000009:adverse effects / Q000494:pharmacology; D002986:Clinical Trials as Topic; D006801:Humans; D008297:Male; D008842:Microfilariae / Q000187:drug effects; D008875:Middle Aged; D009854:Onchocerca / Q000187:drug effects*; D009855:Onchocerciasis / Q000188:drug therapy* / Q000469:parasitology
D000655:Amodiaquine