[Endolymphatic polychemotherapy of ovarian cancer].
The results of treatment in 118 patients with ovarian cancer are presented. The sessional doses were as follows: thioTEPA--200--300 mg or cyclophosphamide--3200--4000 mg+5-fluorouracil--2000--3000 mg. Despite the fact that 116 patients had III--IV stages of the disease, the objective effect of the treatment was observed in 95 of them. Thus, the complete disappearance of tumor was gained in 3 cases, reduction of the tumor size more than by 50%--in 68 patients, more than by 25%--in 18, an insignificant diminishing of tumor, the appearance of its mobility--in 13. Surgical intervention has been performed in 96 patients, that makes 82% of the operability. Supravaginal amputation of the uterus with adnexa and extirpation of the greater omentum have been performed in 76 cases, that yields 67% of resectability. Sole tumors have been removed in 11 patients, the intervention being confined to laparotomy in 6 (5.1%). Pronounced degenerative and necrobiotic alterations in the tumor were revealed by its histochemical assay in 22 patients 40, 50 and 60 days after endolymphatic infusion of chemotherapeutic drugs.
D000293:Adolescent; D000328:Adult; D000368:Aged; D003520:Cyclophosphamide / Q000008:administration & dosage; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D007272:Injections, Intralymphatic; D008207:Lymphatic Metastasis; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013852:Thiotepa / Q000008:administration & dosage; D013997:Time Factors
D003520:Cyclophosphamide; D013852:Thiotepa; D005472:Fluorouracil
Endolimfaticheskaia polikhimioterapiia u bol'nykh rakom iaichnikov.