[Build up of a given concentration of tobramycin and sisomycin in the blood of young children by the intravenous infusion of the antibiotics according to a calculated regimen].
Three regimens for intravenous infusion of tobramycin and sisomicin in doses of 1.33 and 1 mg/kg, respectively were analysed theoretically with the use of the constants of a two-compartmental model characterizing the tobramycin pharmacokinetics in adults. The regimen implied administration of the antibiotics by means of a 12-hour infusion. The second regimen consisted of a jet injection of the initial dose simultaneously with the beginning of the maintenance infusion. The third regimen consisted of a rapid initial infusion followed by a slow maintenance infusion. It was shown that maintenance of the drug concentration at the required levels, i.e. 2-8 microgram/ml for tobramycin and 2-61 microgram/ml for sisomicin was most safely provided by the regimen of the subsequent infusions. This regimen was tried clinically in the treatment of 17 children aged 2 months to 2.5 years with severe forms of acute pneumonia. The rate of the 25-minute initial infusion of tobramycin was 22.2 microgram/kg . min and that of the subsequent 2.7-hour maintenance infusion was 4.85 microgram/kg . min, the total dose being 1.33 mg/kg. The rate of the 20-minute initial infusion of sisomicin was 21.7 microgram/kg . min and that of the subsequent 2.4-hour maintenance infusion was 3.88 microgram/kg . min, the total dose being 1 mg/kg. It was shown that the levels of both the antibiotics in the blood serum of the patients were within the required ranges.
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D002675:Child, Preschool; D002986:Clinical Trials as Topic; D005839:Gentamicins / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D007263:Infusions, Parenteral / Q000379:methods; D007700:Kinetics; D008433:Mathematics; D012853:Sisomicin / Q000008:administration & dosage* / Q000097:blood; D013997:Time Factors; D014031:Tobramycin / Q000008:administration & dosage* / Q000097:blood
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D014031:Tobramycin; D012853:Sisomicin
Sozdanie zadannoĭ kontsentratsii tobramitsina i sizomitsina v krovi deteĭ rannego vozrasta putem vnutrivennoĭ infuzii antibiotikov v raschetnom rezhime.