Amphetamine stereotypy is not a homogeneous phenomenon: sniffing and licking show distinct profiles of sensitization and tolerance.
Sniffing and licking components of amphetamine-induced stereotypy were studied separately during chronic drug treatment. Sniffing showed a gradual increase, or sensitization, in intensity and duration. By contrast, licking developed tolerance for approximately the first 21 days, followed by a progressive increase. Stereotypy is therefore not a homogeneous phenomenon, and sniffing and licking are probably subserved by distinct neuroanatomic substrates. The sensitization of sniffing behavior may be related to the induction of amphetamine-induced paranoid psychosis in humans.
D000818:Animals; D001519:Behavior / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004361:Drug Tolerance; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*; D013997:Time Factors
D003913:Dextroamphetamine; D009638:Norepinephrine