Brain TRH levels during development of the rat, in neonatal hypothyroidism and after caloric deprivation.
The effect of neonatal hypothyroidism and neonatal caloric deprivation on brain TRH levels and serum and pituitary TSH levels has been determined in rats on the following postnatal days: 1, 5, 10, 15, 25, 40 and 60. After neonatal hypothyroidism, there was a slight reduction in brain TRH content although TRH concentration in the brain increased. Serum TSH was elevated at birth, suggesting that the feedback of thyroid hormones on the pituitary gland acts in rat fetuses. After neonatal caloric deprivation, a decrease in brain TRH content was observed along with a decrease in circulating TSH levels, however, there was no change in brain TRH concentration.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001921:Brain / Q000254:growth & development; D001923:Brain Chemistry; D003409:Congenital Hypothyroidism; D002149:Energy Intake; D007037:Hypothyroidism / Q000378:metabolism*; D009748:Nutrition Disorders / Q000378:metabolism*; D009929:Organ Size; D010902:Pituitary Gland / Q000254:growth & development; D051381:Rats; D013972:Thyrotropin / Q000032:analysis / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000032:analysis*
D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin