Enhancement of antigen-induced tracheal contraction by cyclooxygenase inhibition.
Enhancement of allergic tracheal constriction and contraction of the trachea by AA in the presence of cyclooxygenase inhibitors may reflect diversion of AA metabolism from the cyclooxygenase pathway.
D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D016861:Cyclooxygenase Inhibitors; D006168:Guinea Pigs; D006967:Hypersensitivity / Q000503:physiopathology*; D007213:Indomethacin / Q000494:pharmacology*; D016859:Lipoxygenase Inhibitors; D008297:Male; D008469:Meclofenamic Acid / Q000494:pharmacology*; D010047:Ovalbumin / Q000276:immunology; D011458:Prostaglandins E / Q000378:metabolism; D011720:Pyrazoles / Q000494:pharmacology; D014132:Trachea / Q000503:physiopathology; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D016861:Cyclooxygenase Inhibitors; D016859:Lipoxygenase Inhibitors; D011458:Prostaglandins E; D011720:Pyrazoles; D062367:ortho-Aminobenzoates; D008469:Meclofenamic Acid; D010047:Ovalbumin; C015429:phenidone; D007213:Indomethacin