[Morphogenesis of the embryonic head of the chicken following treatment of the isolated brain with actinomycin D and puromycin. First observations].
Isolated brains of 40 hours-old chick embryos are treated by actinomycin D or puromycin solutions at various concentrations and during a relatively short time. Actinomycin D induced ocular malformations varying from subnormal types to anophthalmy. Above a certain concentration, it inhibits lens development. Puromycin is less powerful and determines microphthalmy and synophthalmy, with lens formation in all cases. It seems that actinomycin D could diffuse from the brain to the optic vesicles and inhibit their inductive influence upon the lentogen placodes.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000196:embryology*; D002642:Chick Embryo; D003609:Dactinomycin / Q000494:pharmacology*; D005124:Eye Abnormalities; D005146:Facial Asymmetry / Q000196:embryology; D006257:Head / Q000196:embryology / Q000254:growth & development; D011691:Puromycin / Q000494:pharmacology*
D003609:Dactinomycin; D011691:Puromycin
Morphogenèse de la tête embryonnaire du poulet après traitement de l'encéphale isolé par l'actinomycine D et la puromycine. Premières observations.