Tissue reaction to and fate of parenterally administered titanium dioxide. I. The intraperitoneal site in male Marsh-Buffalo mice.
In 32 male Marsh-Buffalo mice each receiving a saline suspension of 25 mg TiO2 intraperitoneally, four neoplasms appeared over the 18-month experimental period. During this time, four neoplasms appeared in 30 control mice receiving isotonic saline by the same injection route. A nonsignificant association of tumorigenesis with experimental treatment indicated a lack of carcinogenic potential for TiO2 and is discussed in terms of the local tissue reaction in the mice that received the TiO2. Focal deposits of dose material rather than a diffuse distribution were found on the intraperitoneal wall and muscles as well as the gut. In some instances, TiO2 had migrated from the initial injection site. For the most part, no foreign-body reaction to TiO2 involving the presence of macrophages or characteristic capsular connective tissue formation was demonstrated, although a dose deposit attached to the peritoneum by a transparent membrane was observed. In one mouse, chronic myositis developed in muscle tissue containing a large amount of dose material.
D000818:Animals; D005549:Foreign-Body Reaction; D006099:Granuloma / Q000209:etiology; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D013627:Talc / Q000009:adverse effects; D014025:Titanium / Q000378:metabolism / Q000633:toxicity*
D013627:Talc; C009495:titanium dioxide; D014025:Titanium