Colchicine in generalized pustular psoriasis: clinical response and antibody-dependent cytotoxicity by monocytes and neutrophils.
Four patients with generalized pustular psoriasis were treated with oral colchicine in an open study. Three of the four patients went into total remission within two weeks while receiving colchicine. The monocyte- and neutrophil function was assessed by studying antibody-dependent cytotoxicity. Increased values observed before treatment decreased during treatment. The patient who responded poorest clinically also showed less changes in monocyte- and neutrophil antibody-dependent cytotoxicity.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D000920:Antibody-Dependent Cell Cytotoxicity; D002648:Child; D002986:Clinical Trials as Topic; D003078:Colchicine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D011565:Psoriasis / Q000188:drug therapy* / Q000276:immunology
D003078:Colchicine