Cholestasis in infancy and childhood.
Many disorders are capable of producing cholestasis in infancy. Primary hepatobiliary diseases and systemic infectious, toxic, and metabolic insults may present clinically as conjugated hyperbilirubinemia. A careful, organized diagnostic evaluation allows early identification of potentially treatable lesions. Recent success in the surgical management of biliary atresia, previously a uniformly fatal disorder, has emphasized the need for early diagnosis. Medical management of the complications of chronic cholestasis remains a major challenge. Liver transplantation currently offers the only chance for long-term survival for infants with progressive cirrhosis.
D001646:Bile / Q000378:metabolism; D001652:Bile Ducts / Q000002:abnormalities / Q000601:surgery; D001660:Biliary Tract Diseases / Q000175:diagnosis; D002648:Child; D002675:Child, Preschool; D002779:Cholestasis / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016031:Liver Transplantation; D008297:Male; D008722:Methods