Immunotherapy of the guinea pig line 10 hepatocarcinoma with a variety of nonviable bacteria.
A variety of heat-killed bacteria were tested for their capacity to induce regressions of established line 10 hepatocarcinomas in syngeneic guinea pigs. Multiple intralesional injections of heat-killed Escherichia coli, Streptococcus mutans, Listeria monocytogenes, and Propionibacterium acnes resulted in complete regression of the tumor in a majority of guinea pigs. Repeated injections of heat-killed Mycobacterium bovis strain Bacillus Calmette-Guérin caused no regressions. Surviving animals were immune to subsequent challenge with line 10 cells but not L2C cells, another syngeneic tumor.
D000818:Animals; D001428:Bacterial Vaccines / Q000627:therapeutic use*; D002460:Cell Line; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D006168:Guinea Pigs; D007114:Immunization; D007271:Injections, Intradermal; D008089:Listeria monocytogenes / Q000276:immunology; D008114:Liver Neoplasms, Experimental / Q000276:immunology / Q000628:therapy*; D008297:Male; D009368:Neoplasm Transplantation; D011425:Propionibacterium acnes / Q000276:immunology; D013295:Streptococcus mutans / Q000276:immunology; D014185:Transplantation, Isogeneic
D001428:Bacterial Vaccines