[Non-tropical sprue discrepancy between clinical and biopsy findings. Five years' observation of a case (author's transl)].
After doagnosis and establishment of an appropriate diet a 51-year-old female patient with coeliac disease, who was critically ill in the beginning, became symptomless; nevertheless, a five year follow-up study with mucosa biopsies reveals a persisting villous atrophy with hyperplastic crypts ("flat mucosa"). This discrepancy between clinical and histological findings is discussed and it is emphasized that for coeliac patients a strict adherence to a gluten-free diet and bioptic supervision of therapy are essential. Treatment aimed solely at abolishing the clinical symptoms obviously bears the risk of a persisting symptomless illness and the danger of late complications.
D001706:Biopsy; D002446:Celiac Disease / Q000175:diagnosis / Q000178:diet therapy / Q000473:pathology*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D007583:Jejunum / Q000473:pathology; D008875:Middle Aged
Einheimische Sprue-Diskrepanz von klinischem und bioptischem Befund. Eine Verlaufsbeobachtung über fünf Jahre.