[Effect of T-activin and hydrocortisone on transplantation immunity].
The response of thymectomized and lethally irradiated adult CBA mice to C57Bl/6 mouse skin grafts was studied after recipient protection by syngeneic bone marrow treated in vitro with T-activin, an active factor of the calf thymus with a molecular weight from 1500 to 6000 dalton, and with hydrocortisone for 30 min at 37 degrees C. Bone marrow cells treated with T-activin coupled with hydrocortisone or with T-activin alone induced the development of transplantation immunity in 85 and 80% of the recipients, respectively. Syngeneic bone marrow cells from hydrocortisone-treated donors recovered transplantation immunity in all the donors.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D016026:Bone Marrow Transplantation; D006854:Hydrocortisone / Q000276:immunology*; D066298:In Vitro Techniques; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D016038:Skin Transplantation; D013934:Thymectomy; D014181:Transplantation Immunology / Q000187:drug effects* / Q000528:radiation effects
D006854:Hydrocortisone
Vliianie T-aktivina i gidrokortizona na transplantatsionnyĭ imunitet.