Anatomical bases of peritoneal permeability: a reappraisal. Anatomy of peritoneum.
The peritoneal membrane consists of flat mesothelial cells linked together with digitations and containing vesiculae with pinocytic capacity, of endothelial cells (containing Weibel-Palade's bodies and vesiculae) and of an interstitial tissue consisting of a network of watery channels. The cellular structures of mesothelium and endothelium are characterized by tight and gap junctions or perhaps by macular junctions. The visceral peritoneum shows a prevalence of gap junctions, the pericysic veins contain only tight junctions while both types can be found in the arterioles. Two different ways for solute transport are theoretically possible: the vesicles of plasmalemma (via pinocytosis) and the junctions (via size-sieving effect). Studies with tracers did not furnish unequivocal data on this problem and did not clarify if these structures could be the equivalent of the pores of the Landis-Pappenheimer's theory. The studies of Karnowsky and Simionescu, using tracers, have in fact given opposite results.
D000818:Animals; D004727:Endothelium / Q000166:cytology / Q000502:physiology; D006801:Humans; D008854:Microscopy, Electron; D008858:Microscopy, Phase-Contrast; D010537:Peritoneum / Q000033:anatomy & histology / Q000166:cytology* / Q000502:physiology; D010539:Permeability