[Blood pressure and renin under treatment of hypertension with guanfacine (author's transl)].
The effect of treatment with guanfacine for 12 weeks on blood pressure and plasma renin activity was investigated in 24 hypertensive patients (WHO I--III). After 4 weeks of treatment with varying doses, the blood pressure decreased to 157/91/118 mmHg, and after 12 weeks of treatment it leveled off at 147/83/109 mmHg. Heart rate remained essentially unchanged throughout the observation period. Renin values decreased under therapy from 3.3 to 2.3 ng/ml/h, but at no time during treatment did this decrease correlate with that of blood pressure. Guanfacine treatment is accompanied by relatively few and slight side-effects.
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D016316:Guanfacine; D006146:Guanidines / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010648:Phenylacetates / Q000627:therapeutic use*; D012083:Renin / Q000097:blood*
D000959:Antihypertensive Agents; D006146:Guanidines; D010648:Phenylacetates; D016316:Guanfacine; D012083:Renin
Blutdruck und Renin unter Behandlung mit Guanfacin bei Hochdruck.