Haemoglobin synthesis in bone marrow of patients with beta O and beta +-thalassaemia.
Haemoglobin synthesis was studied in bone marrow erythroblasts and in reticulocytes of 4 children with beta O-thalassaemia major and of 7 children with beta +-thalassaemia major. In patients with beta O-thalassaemia the gamma/a ratio was found to be lower in bone marrow than in peripheral blood. On the contrary, in patients with beta + thalassaemia the beta + gamma/a ratio was more balanced in bone marrow, where the beta-chain synthesis was higher, than in reticulocytes. This last result could be explained by the presence of an abnormal m-RNA for beta-chains in beta +-thalassaemia.
D001853:Bone Marrow / Q000378:metabolism*; D001854:Bone Marrow Cells; D002648:Child; D002675:Child, Preschool; D004900:Erythroblasts / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D006454:Hemoglobins / Q000096:biosynthesis*; D006801:Humans; D007223:Infant; D012156:Reticulocytes / Q000378:metabolism; D013789:Thalassemia / Q000097:blood / Q000145:classification / Q000378:metabolism*
D006454:Hemoglobins