Aciclovir and trifluorothymidine in herpetic keratitis. Preliminary report of a multicentered trial.
The efficacy of Aciclovir and Trifluorothymidine (TFT) treatment was tested in a double blind trial of thirty-eight patients with dendritic keratitis. All twenty patients treated with Aciclovir healed within 10 days with an average healing time of 5.0 days. Two of the eighteen patients treated with TFT failed to heal within 22 days, the others healed within ten days, the average healing was 6.6 days. Punctate keratopathy was seen in 70% of both groups. Intense conjunctival hyperaemia developed in two TFT patients.
D000212:Acyclovir; D000818:Animals; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D006147:Guanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D011817:Rabbits; D013936:Thymidine / Q000031:analogs & derivatives*; D014271:Trifluridine / Q000627:therapeutic use*
D006147:Guanine; D014271:Trifluridine; D013936:Thymidine; D000212:Acyclovir