title: Mutagenicity study of Remsen-Fahlberg saccharin and contaminants.
abstract: Saccharin and contaminants of commercial Remsen-Fahlberg saccharin were studied for mutagenic potential with the use of the Salmonella/microsome test, Basc-test in Drosophila melanogaster and micronucleus test in mice. In none of these tests were mutagenic effects of saccharin observed. Likewise, the ortho- and para-sulfamoylbenzoic acids (OSBA and PSBA) were ineffective. Para-toluenesulfonamide (PTS) and the major contaminant ortho-toluene-sulfonamide (OTS) exhibited weak mutagenic effects in a modified Salmonella/microsome test and in Drosophila. These results do not indicate mutagenic and therewith correlated carcinogenic potential of saccharin, but they emphasize the possible activity of contaminants.
mesh_terms: D000818:Animals; D001565:Benzoates / Q000633:toxicity; D004331:Drosophila melanogaster; D004340:Drug Contamination; D005260:Female; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D012439:Saccharin / Q000633:toxicity*; D013449:Sulfonamides / Q000633:toxicity; D014050:Toluene / Q000031:analogs & derivatives*; D014105:Tosyl Compounds / Q000633:toxicity; D000096926:Benzenesulfonamides
chemical_list: D001565:Benzoates; D009153:Mutagens; D012439:Saccharin; D013449:Sulfonamides; D014050:Toluene; D014105:Tosyl Compounds; C001910:carzenide; C025417:4-toluenesulfonamide; D000096926:Benzenesulfonamides; C013307:2-toluenesulfonamide