Fredericamycin A, a new antitumor antibiotic. I. Production, isolation and physicochemical properties.
A new antitumor antibiotic, fredericamycin A (FCRC-A48, NSC-305263), has been isolated from a strain of Streptomyces griseus (FCRC-48). Based on its unique ultraviolet-visible spectrum, infrared spectrum, proton and carbon-13 nuclear magnetic resonance spectra and mass spectra, it is judged to be a novel acid-base indicator type of compound. Its production, isolation and physicochemical properties are discussed. The isolation, ultraviolet-visible spectrum and some biological properties of two minor components, fredericamycin B and fredericamycin C, are also described.
D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D005285:Fermentation; D007546:Isoquinolines / Q000302:isolation & purification; D013141:Spiro Compounds / Q000302:isolation & purification; D013305:Streptomyces griseus / Q000378:metabolism
D000903:Antibiotics, Antineoplastic; D007546:Isoquinolines; D013141:Spiro Compounds; C016660:fredericamycin A