Amino acid transport via the red cell anion transport system.
Evidence is presented that the red cell anion-exchange transporter (Band 3) can selectively transport small neutral amino acids, including glycine, serine and cysteine, but not alanine, proline, valine and threonine. This transport is inhibited by micromolar concentrations of SITS (4-acetamido-4'-isothiocyanostilbene-2,2'-disulphonate), and increased by raising the pH from 6.5 to 8.5.
D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid / Q000494:pharmacology; D000409:Alanine / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D002352:Carrier Proteins / Q000378:metabolism*; D003545:Cysteine / Q000378:metabolism; D003864:Depression, Chemical; D004912:Erythrocytes / Q000378:metabolism*; D005998:Glycine / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D011392:Proline / Q000378:metabolism; D012694:Serine / Q000378:metabolism; D013912:Threonine / Q000378:metabolism; D014633:Valine / Q000378:metabolism
D000596:Amino Acids; D002352:Carrier Proteins; D012856:4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic Acid; D013912:Threonine; D012694:Serine; D011392:Proline; D014633:Valine; D003545:Cysteine; D000409:Alanine; D005998:Glycine