Mutagenic effects of fluphenazine hydrochloride in Drosophila melanogaster.
The mutagenic potential of fluphenazine hydrochloride was tested on male germ cells of Drosophila melanogaster. The criterion used was sex-linked recessive lethal mutations. Oregon-K males of D. melanogaster, reared on a medium containing 0.01, 0.02 and 0.03 mg/ml of the drug, were screened for sex-linked recessive lethal mutations. The incidence of sex-linked lethals was significant. The results clearly demonstrate that fluphenazine is capable of inducing recessive lethal mutations in Drosophila especially in pre-meiotic stages of spermatogenesis.
D000818:Animals; D004331:Drosophila melanogaster; D005260:Female; D005476:Fluphenazine / Q000633:toxicity*; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*
D009153:Mutagens; D005476:Fluphenazine