Regulation of the production of murine IgG2a by an H-2-linked gene and other unlinked genes.
Alleles of at least two loci (rig-1 and Rig-2) regulate the levels of serum immunoglobulin of the Igh-1b class and allotype in BALB/c Igb (BAB/14) and (BALB/c x BAB/14)F1 mice. The combined effect of the BALB/c alleles at these two loci is to lower Igh-1b levels significantly below those observed in other strains and below their own levels of Igh-1a in allotype heterozygous mice. The rig-1 locus is closely linked to or within the H-2 complex. Two alleles have been defined: rig-1d and rig-1b in H-2d and H-2b haplotypes, respectively. Homozygous rig-1d animals heterozygous for the BALB/c Rig-2 allele(s) have very low levels of Igh-1b. The designation of Rig-2 is provisional since it has not been mapped or defined as a single locus.
D000818:Animals; D005796:Genes; D005799:Genes, Dominant; D005802:Genes, MHC Class II; D005808:Genes, Recessive; D005809:Genes, Regulator; D006183:H-2 Antigens / Q000235:genetics*; D007126:Immunoglobulin Allotypes / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis*; D008285:Major Histocompatibility Complex; D051379:Mice
D006183:H-2 Antigens; D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G