Assessment of synthetic steroid (Org OD 14): effect on skeletal metabolism by 24-h whole-body retention of diphosphonate.
Using a 24-h whole-body retention (WBR) of Tc99m hydroxyethylidene diphosphonate (HEDP), a sensitive measure of skeletal metabolism, 24 women receiving the synthetic steroid hormone Org OD 14 were studied. OD 14 was found to have a powerful suppressive effect on skeletal metabolism in both oophorectomized and non-oophorectomized women when compared with control subjects (P less than 0.001 and P less than 0.01, respectively). The degree of suppression was similar to that found with oestrogen therapy. While it has previously been shown that OD 14 prevents bone mineral loss (as measured by photon-absorptiometry), the present study provides further evidence as to the efficacy of this compound in suppressing skeletal metabolism.
D000469:Alkaline Phosphatase / Q000097:blood; D045930:Anabolic Agents / Q000494:pharmacology*; D001842:Bone and Bones / Q000187:drug effects / Q000378:metabolism*; D002118:Calcium / Q000097:blood; D002369:Castration; D012968:Etidronic Acid; D005260:Female; D006728:Hormones / Q000494:pharmacology*; D006801:Humans; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism; D009652:Norpregnenes / Q000494:pharmacology*; D015609:Organotechnetium Compounds; D010281:Parathyroid Hormone / Q000097:blood; D013667:Technetium; D014915:Whole-Body Counting
D045930:Anabolic Agents; D006728:Hormones; D008903:Minerals; D009652:Norpregnenes; D015609:Organotechnetium Compounds; D010281:Parathyroid Hormone; C019561:technetium Tc 99m etidronate; D013667:Technetium; D000469:Alkaline Phosphatase; C027385:tibolone; D012968:Etidronic Acid; D002118:Calcium