title: Repair of O6-methylguanine in rat liver DNA is enhanced by pretreatment with single or multiple doses of aflatoxin B1.
abstract: Pretreatment of rats by the repeated administration of certain alkylating carcinogens has been shown to stimulate the removal of O6-alkylguanine from hepatic DNA. Prolonged feeding with the aromatic amide 2-acetylaminofluorene has a similar effect. In this report, aflatoxin B1, an agent from another chemically distinct class of carcinogen, is shown to be capable of stimulating the repair of O6-methylguanine in hepatic DNA. The sensitivity of this system is shown by the fact that this repair response can be fully stimulated as early as 1 day after treatment with a single dose.
mesh_terms: D000225:Adenine / Q000031:analogs & derivatives / Q000096:biosynthesis; D016604:Aflatoxin B1; D000348:Aflatoxins / Q000494:pharmacology*; D000818:Animals; D004260:DNA Repair / Q000187:drug effects*; D004128:Dimethylnitrosamine / Q000494:pharmacology; D006147:Guanine / Q000031:analogs & derivatives* / Q000096:biosynthesis; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical
chemical_list: D000348:Aflatoxins; C025946:3-methyladenine; D006147:Guanine; C008449:O-(6)-methylguanine; D016604:Aflatoxin B1; D000225:Adenine; D004128:Dimethylnitrosamine