Inhibition of secondary IgG responses by monosaccharides: evidence for I-region control.
Certain monosaccharides selectively inhibit secondary IgG responses in vitro. Genetic analyses described in this report revealed that the inhibitory sugars differed between mouse strains and these differences mapped to the I-J and I-C subregions of the murine MHC. These results imply that interaction between T and B lymphocytes can involve the recognition of I-region controlled carbohydrate structures.
D000116:Acetylgalactosamine / Q000494:pharmacology; D000818:Animals; D001667:Binding, Competitive; D004136:Dinitrobenzenes / Q000276:immunology; D005260:Female; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics; D006433:Hemocyanins / Q000276:immunology; D007117:Immunization, Secondary; D007074:Immunoglobulin G / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009005:Monosaccharides / Q000494:pharmacology*; D011995:Recombination, Genetic
D004136:Dinitrobenzenes; D006183:H-2 Antigens; D007074:Immunoglobulin G; D009005:Monosaccharides; D006433:Hemocyanins; D000116:Acetylgalactosamine