title: [Is myositis in chronic polyarthritis using d-penicillamine drug-induced?].
abstract: Myositis was diagnosed twenty months after starting treatment with d-penicillamine in a patient suffering from uncomplicated rheumatoid arthritis for nearly three years. The diagnosis was established by electromyographic investigation and by biopsy. In this patient d-penicillamine had been intermittently increased to a dose over 1 g per day and then reduced because of mild proteinuria. The appearance of myositis during d-penicillamine therapy, its immediate regression on discontinuing the drug, and the absence of signs of vasculitis or other extraarticular manifestations in this patient suggest that this complication may be drug-induced. The clinical course is compared with isolated cases reported in the literature. The significance of this rare side effect is discussed.
mesh_terms: D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006052:Gold Sodium Thiomalate / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009132:Muscles / Q000473:pathology; D009220:Myositis / Q000139:chemically induced* / Q000473:pathology; D010396:Penicillamine / Q000009:adverse effects / Q000627:therapeutic use; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D006052:Gold Sodium Thiomalate; D010396:Penicillamine; D011241:Prednisone
vernacular_title: Myositis bei chronischer Polyarthritis unter d-Penicillamin, medikamentös induziert?