[Penicillin resistance due to the production of a beta-lactamase in Clostridium butyricum].
Eight strains of clostridia of the butyricum group, resistant to penicillins were isolated from perinatal infections. MIC's of these strains vary from 1,000 to 3,000 micrograms/ml for benzyl-penicillin, and from 5 to 10 micrograms/ml for cefoxitin. The substrate profile of the enzymes is that of a penicillinase.
D003013:Clostridium / Q000187:drug effects / Q000201:enzymology*; D006801:Humans; D007231:Infant, Newborn; D010403:Penicillin Resistance; D010405:Penicillinase / Q000096:biosynthesis*; D001618:beta-Lactamases / Q000096:biosynthesis*
D010405:Penicillinase; D001618:beta-Lactamases
Résistance aux pénicillines due à la production d'une béta-lactamase chez les Clostridium du groupe butyricum.