title: Parenteral nutrition and repeated hemodialysis of bilaterally nephrectomized conscious dogs. II. Metabolic studies.
abstract: To realize equilibrated metabolic conditions after bilateral Nx, three male mongrel dogs were exclusively fed by parenteral infusions with a dog-specific compound of EAA, glutamate, and/or glucose (0.19 g nitrogen and/or 52-70 kcal per kg and day). Daily dialyses required by infusion volumes up to 65 ml/kg/day were performed by means of a closed batch hemodialysis system (Rhodial 75) and highly permeable membranes (RP 6), which allowed a precise ultrafiltration control and direct dialysate analysis. Comparing the urea nitrogen production in a pre- and post-nephrectomy period with a 4 successive days' schedule of only glucose, followed by amino acid administration, a marked decrease of net urea nitrogen excretion was noted after nephrectomy, when EAA were supplied.
mesh_terms: D000601:Amino Acids, Essential / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004044:Dietary Proteins / Q000378:metabolism; D004285:Dogs; D004734:Energy Metabolism; D008297:Male; D009392:Nephrectomy; D010288:Parenteral Nutrition; D010289:Parenteral Nutrition, Total; D006435:Renal Dialysis; D014511:Uremia / Q000378:metabolism
chemical_list: D000601:Amino Acids, Essential; D001786:Blood Glucose; D004044:Dietary Proteins; D003404:Creatinine