Chromium genotoxicity as influenced by complexation and rate effects.
Conclusions as to the mutagenicity and carcinogenicity of metal salts can be ambiguous and misleading, especially for metal ions having a high charge/radius ratio, hence a strong tendency to hydrolyze. Using the rec-assay, we determined whether the mutagenicity of chromium salts was reduced by complexation, as in the case of Cr(VI), or induced in the case of Cr(III). We find that several chelants, in proportion to concentration, reduce or eliminate the mutagenicity of Cr2O32-. These include EDTA, salicylate (SA), and Tiron (disodium 1,2-dihydroxylbenzene-3,5-disulfonate). Cr(III) was rendered slightly mutagenic by salicylate and citrate. None of the chelating agents or their combinations were mutagenic.
D001412:Bacillus subtilis / Q000235:genetics; D002273:Carcinogens; D002614:Chelating Agents / Q000494:pharmacology; D002857:Chromium / Q000633:toxicity*; D009153:Mutagens; D011995:Recombination, Genetic / Q000187:drug effects; D012486:Salmonella typhimurium / Q000235:genetics; D013997:Time Factors
D002273:Carcinogens; D002614:Chelating Agents; D009153:Mutagens; D002857:Chromium