Glycoprotein metabolism in the guinea-pig gastric mucosa in chronic metribuzin poisoning.
Forty male guinea pigs weighting 400--600 g, 8 months old, were given metribuzin directly into the gastric lumen over a period of 30 days (20 animals) or 90 days (20 animals), 6 times a week. The intoxicated animals showed in the gastric mucosa a significant decrease in glucosamine isomerase activity and a significant increased in beta-glucosidase and beta-galactosidase activity. The results suggest that the biosynthesis of the sugar moiety of glycoproteins is depressed, the degradation of glycoproteins is stimulated by metribuzin.
D000818:Animals; D002238:Carbohydrate Epimerases / Q000378:metabolism*; D005696:Galactosidases / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000201:enzymology*; D005959:Glucosidases / Q000378:metabolism*; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing) / Q000378:metabolism*; D006023:Glycoproteins / Q000378:metabolism; D006168:Guinea Pigs; D006540:Herbicides / Q000633:toxicity; D007700:Kinetics; D008297:Male; D014227:Triazines / Q000008:administration & dosage / Q000633:toxicity*; D001616:beta-Galactosidase / Q000378:metabolism*; D001617:beta-Glucosidase / Q000378:metabolism*
D006023:Glycoproteins; D006540:Herbicides; D014227:Triazines; D005945:Glutamine-Fructose-6-Phosphate Transaminase (Isomerizing); D005696:Galactosidases; D005959:Glucosidases; D001617:beta-Glucosidase; D001616:beta-Galactosidase; D002238:Carbohydrate Epimerases; C009235:metribuzin