Effect of pirprofen on glibenclamide kinetics and response.
Pirprofen (a new non-steroidal anti-inflammatory agent), 200 mg 8 hourly, or placebo was administered orally to eight normal volunteers to investigate its effect on the pharmacokinetics and glucose and insulin responses after 1 mg i.v. glibenclamide. No significant changes were produced in these measures and in vitro studies showed no displacement of glibenclamide by pirprofen from plasma protein binding.
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D005905:Glyburide / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D007328:Insulin / Q000097:blood; D007700:Kinetics; D008297:Male; D010666:Phenylpropionates / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001786:Blood Glucose; D007328:Insulin; D010666:Phenylpropionates; D005905:Glyburide; C008924:pirprofen