title: [Acquired Willebrand factor deficiency associated with monoclonal IgG kappa gammapathy. Presence of an inhibitor of ristocetin co-factor (author's transl)].
abstract: An 85-year-old woman without personal history of haemorrhages was found to have qualitative and quantitative deficiency of Factor VIII persisting at least 6 months. Asymptomatic monoclonal IgG kappa gammopathy was also discovered in the same patient, together with a circulating inhibitor of ristocetin co-factor. The fact that the inhibitory effect was reduced after the patient's serum IgG's were bound to staphylococcal protein A suggests that the inhibitor belonged to that category of immunoglobulins, although the authors were unable to detect it after elution.
mesh_terms: D000368:Aged; D001779:Blood Coagulation Factors / Q000037:antagonists & inhibitors*; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000097:blood / Q000150:complications*; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D014842:von Willebrand Diseases / Q000097:blood / Q000150:complications*; D014841:von Willebrand Factor / Q000037:antagonists & inhibitors*
chemical_list: D001779:Blood Coagulation Factors; D007074:Immunoglobulin G; D007145:Immunoglobulin kappa-Chains; D014841:von Willebrand Factor
vernacular_title: Déficit acquis en facteur Willebrand associé à une gammapathie monoclonale IgG kappa. Présence d'un inhibiteur dirigé contre le cofacteur de la ristocétine.