[Protective effect of P40 fraction of C. granulosum against leukemia L1210 in mice].
Administration of glutaraldehyde treated L1210 leukemia cells, either alone or coupled with tetanus toxoid by means of glutaraldehyde as well as L1210 cells inactivated by mitomycin, did not induce appreciable protection against a tumorigenic dose of L1210 cells. On the other hand, injection of P40 fraction of C. granulosum induced non-specific resistance to L1210 leukemia and increased the efficiency of specific immunization by either glutaraldehyde treated L1210 cells or cells coupled with tetanus toxoid. Injection of Freund's complete adjuvant resulted in increase of rate of mortality after challenge with L1210 cells.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D003352:Corynebacterium; D004357:Drug Synergism; D005620:Freund's Adjuvant / Q000494:pharmacology; D005976:Glutaral / Q000627:therapeutic use; D007113:Immunity, Innate / Q000187:drug effects; D007939:Leukemia L1210 / Q000517:prevention & control*; D008297:Male; D051379:Mice; D008937:Mitomycins / Q000627:therapeutic use; D011424:Propionibacterium / Q000166:cytology*; D013745:Tetanus Toxoid / Q000627:therapeutic use
D000276:Adjuvants, Immunologic; D008937:Mitomycins; D013745:Tetanus Toxoid; D005620:Freund's Adjuvant; D005976:Glutaral
Effet protecteur de la fraction P40 isolée de C. granulosum dans la leucémie L1210 de la souris.