Comparison of drug sensitivities of three strains of Trypanosoma cruzi in inbred A/Jax mice.
The sensitivity to 15 drugs of the Peru, Sonya and Y strains of Trypanosoma cruzi was investigated in inbred A/Jax strain mice. Some variation was seen in the percentage of survivors and more still in the survival times of those that died. Marked variation was seen when the two sets of data were analysed together by Litchfield's rapid graphic method for evaluating  time-percent effect curves. No one strain, however, was found to be especially drug-sensitive and therefore particularly useful in primary drug screening. Furthermore, the differences in sensitivity were apparently not marked and are unlikely to have clinical significance once an effective drug with a high chemotherapeutic index is discovered for Chagas's disease.
D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy* / Q000401:mortality; D004352:Drug Resistance, Microbial; D051379:Mice; D008805:Mice, Inbred A; D008826:Microbial Sensitivity Tests; D014344:Trypanocidal Agents / Q000627:therapeutic use*; D014349:Trypanosoma cruzi / Q000187:drug effects
D014344:Trypanocidal Agents