title: Conditioning of an interoceptive drug stimulus to different exteroceptive contexts.
abstract: Two experiments are described showing that a pentobarbital versus saline discrimination can be differentially conditioned to different external contexts. In experiment 1, rats differentiated two T-shaped mazes (one water maze and one electrified maze). In experiment 2, the external stimuli were the presence and absence of light during training in the electrified T-maze. These experiments constitute the first examples where a single drug versus nondrug discrimination has been conditioned to different external contexts requiring an opposite response pattern by the same animal. The data are in accordance with a stimulus interpretation of drug discrimination learning.
mesh_terms: D000818:Animals; D003213:Conditioning, Psychological / Q000502:physiology*; D003463:Cues; D004193:Discrimination Learning / Q000187:drug effects*; D004597:Electroshock; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats
chemical_list: D010424:Pentobarbital