[Effect of certain GABA-ergic substances on dopamine metabolism in the rat brain].
Effect of the GABA-ergic drugs, sodium hydroxybutyrate, n-dipropylacetate (n-DPA) and piracetam, has been studied on the level of homovanillic acid (HVA) and activity of GABA-transaminase in the striate body of the rat brain. It has been established that piracetam in doses of 500 and 400 mg/kg, n-DPA in a dose of 200 mg/kg and sodium hydroxybutyrate in a dose of 500 mg/kg do not affect the HVA level or activity of GABA-transaminase. The data obtained are likely to support a suggestion about a possible relationship between the GABA-ergic and dopaminergic mediator system.
D000612:4-Aminobutyrate Transaminase / Q000378:metabolism; D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D006719:Homovanillic Acid / Q000032:analysis; D006885:Hydroxybutyrates / Q000494:pharmacology*; D008297:Male; D010889:Piracetam / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology*; D051381:Rats; D012978:Sodium Oxybate / Q000494:pharmacology*; D014635:Valproic Acid / Q000494:pharmacology*
D006885:Hydroxybutyrates; D011760:Pyrrolidinones; D014635:Valproic Acid; D012978:Sodium Oxybate; D000612:4-Aminobutyrate Transaminase; D004298:Dopamine; D006719:Homovanillic Acid; D010889:Piracetam
Vliianie nekotorykh GAMK-ergicheskikh veshchestv na metabolizm dofamina v mozge krysy.