Effect of antacids on the dissolution of minocycline and demethylchlortetracycline from capsules.
The effect of certain antacids on the dissolution of minocycline and demethylchlortetracycline from capsules was studied. It was found that antacids such as aluminium silicate and magnesium trisilicate decreased the dissolution of minocycline and demethyl-chlortetracycline.
D000327:Adsorption; D000863:Antacids; D001682:Biological Availability; D002214:Capsules; D002626:Chemistry, Pharmaceutical; D003707:Demeclocycline / Q000008:administration & dosage; D006851:Hydrochloric Acid; D008911:Minocycline / Q000008:administration & dosage; D012995:Solubility; D013754:Tetracyclines / Q000008:administration & dosage; D013997:Time Factors
D000863:Antacids; D002214:Capsules; D013754:Tetracyclines; D003707:Demeclocycline; D008911:Minocycline; D006851:Hydrochloric Acid