[Double-blind study of lysine acetylsalicylate in the control of postoperative pain of somatic origin].
In 61 patients submitted to subdural anesthesia for orthopedic operations, postoperative somatic pain was treated by double-blind iv injection of lysine acetylsalicylate 1.8 g or placebo randomly. Patients with persistent pain received methadone 10 mg im. No placebo response was obtained; LAS had similar but shorter effects than methadone. No significant side effect was observed.
D000328:Adult; D001241:Aspirin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D001842:Bone and Bones / Q000601:surgery; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008691:Methadone / Q000627:therapeutic use*; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*
D008239:Lysine; D001241:Aspirin; D008691:Methadone; C010395:acetylsalicylic acid lysinate
Studio in doppio cieco dell'acetilsalicilato di lisina nel controllo del dolore post-operatorio di origine somatica.