Jejunal water and electrolyte secretion induced by L-arginine in man.
In this study a perfusion technique has been used to investigate jejunal secretion in response to the dibasic amino acid L-arginine. L-arginine at 5, 15, and 40 mmol/l in isotonic saline solutions induced net intestinal secretion of water and Na+. The structurally similar dibasic amino acid L-lysine caused net absorption at 5 and 15 mmol/l, and only modest net secretion of water and Na+ at 40 mmol/l, although absorption rates of the two amino acids were similar. D-arginine (15 mmol/l) was without effect on net water and Na+ absorption. L-arginine 15 mmol/l inhibited glucose-stimulated water and Na+ absorption when perfused in the same intestinal segment, but was without effect when perfused in separate jejunal or ileal segments. Parenteral chlorpromazine inhibited L-arginine induced jejunal water and Na+ secretion. Jejunal secretion induced by L-arginine thus appears not to be due to passive osmotic water flow, nor to release of circulating secretagogues. Stimulation of a mucosal secretory process is most likely to be the mechanism.
D000328:Adult; D001120:Arginine / Q000494:pharmacology*; D001834:Body Water / Q000378:metabolism*; D002712:Chlorides / Q000378:metabolism; D002746:Chlorpromazine / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects; D007419:Intestinal Secretions / Q000187:drug effects*; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism; D008239:Lysine / Q000494:pharmacology; D008875:Middle Aged; D010477:Perfusion; D012964:Sodium / Q000378:metabolism*
D002712:Chlorides; D001120:Arginine; D012964:Sodium; D005947:Glucose; D008239:Lysine; D002746:Chlorpromazine