[Comparative desaturation of linoleic and dihomo-gamma-linolenic acids by homogenates of human liver in vitro].
Human liver homogenates were incubated with either [1-14C] linoleic or [2-14C] dihomo-gamma-linolenic acid comparatively. It appeared that only dihomo-gamma-linolenic acid could be desaturated in our experimental conditions. However, the desaturating activity was lower than that in Rat liver homogenates. These results are discussed here, and compared to those obtained in other laboratories.
D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D002648:Child; D044943:Fatty Acid Desaturases / Q000378:metabolism; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008041:Linoleic Acids / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D013347:Subcellular Fractions / Q000378:metabolism
D005231:Fatty Acids, Unsaturated; D008041:Linoleic Acids; D044943:Fatty Acid Desaturases; D015126:8,11,14-Eicosatrienoic Acid
Désaturation comparée des acides linoléique et dihomo-gamma-linolénique par des homogénats de foie humain in vitro.