Chemotherapy of Sarcosporidiosis and theileriosis in domestic animals.
In goats infected with Sarcocystis capracanis and sheep infected with S. Ovicanis prophylactical application of halofuginone prevented clinical symptoms but also prevented the development of immunity to homologous challenge. Halofuginone was most effective in the treatment of acute sarcosporidiosis at a dose of 0.67 mg/kg b. w. on two successive days in both goats and sheep. In acute bovine theileriosis (Theileria parva and T. annulata) halofuginone was effective at a single dose about of 1.2 to 2 mg/kg b.w. Cattle recovered from theileriosis through treatment were immune to homologous challenge.
D000818:Animals; D002417:Cattle; D003049:Coccidiostats / Q000627:therapeutic use*; D004338:Drug Combinations; D006041:Goats; D010118:Oxytetracycline / Q000627:therapeutic use; D010880:Piperidines / Q000627:therapeutic use; D011799:Quinazolines / Q000627:therapeutic use; D052999:Quinazolinones; D012523:Sarcocystosis / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*; D013413:Sulfadoxine / Q000627:therapeutic use; D013801:Theileriasis / Q000188:drug therapy*; D014295:Trimethoprim / Q000627:therapeutic use
D003049:Coccidiostats; D004338:Drug Combinations; D010880:Piperidines; D011799:Quinazolines; D052999:Quinazolinones; D013413:Sulfadoxine; D014295:Trimethoprim; C010176:halofuginone; D010118:Oxytetracycline