Prevention of allograft rejection by immunization with donor blood depleted of Ia-bearing cells.
Strain-specific unresponsiveness was induced in adult mice by immunizing them with donor blood treated with antiserum to Ia (I region-associated antigens) prior to the transplantation of islets of Langerhans. This regimen alone produced greater than 100-day survival of islet allografts transplanted across a major histocompatibility barrier.
D000818:Animals; D003165:Complement System Proteins; D003921:Diabetes Mellitus, Experimental / Q000276:immunology; D004912:Erythrocytes / Q000276:immunology; D006085:Graft Survival; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D007106:Immune Sera; D007114:Immunization; D007165:Immunosuppression Therapy; D016381:Islets of Langerhans Transplantation; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D014184:Transplantation, Homologous
D000949:Histocompatibility Antigens Class II; D007106:Immune Sera; D003165:Complement System Proteins