Influence of anxiolytic drugs (Prazepam and Diazepam) on respiratory center output and CO2 chemosensitivity in patients with lung diseases.
Occlusion pressure at 0.1 s (P0.1) and its evolution during progressive hyperoxic hypercapnia (CO2 chemosensitivity) were measured in 40 patients. Most of them (26) were affected by asthma and /or chronic bronchitis and had mild obstruction and hypoxemia. Measurements were made after 2 days of oral prazepam, diazepam or a placebo (single-blind study). Diazepam induced a significant decrease in P0.1 without affecting CO2 chemosensitivity. In contrast, prazepam did not significantly modify P0.1 or CO2 chemosensitivity. However, P0.1 decreased in 5/18 individual cases. 1 week of treatment by prazepam has advantages over diazepam by not depressing respiratory center output.
D001249:Asthma / Q000503:physiopathology; D001991:Bronchitis / Q000503:physiopathology; D002245:Carbon Dioxide / Q000502:physiology; D003975:Diazepam / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006935:Hypercapnia / Q000503:physiopathology; D008171:Lung Diseases / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011222:Prazepam / Q000494:pharmacology*; D012119:Respiration; D012125:Respiratory Center / Q000503:physiopathology*
D002245:Carbon Dioxide; D011222:Prazepam; D003975:Diazepam