title: B lymphocyte immune response gene phenotype is genetically determined.
abstract: We examined the effects of the developmental milieu on the capacity of B cells to undergo immune response gene-controlled, T cell-dependent polyclonal proliferation. Although I-Aq poly(Glu60 Ala30 Tyr10)n (GAT)-nonresponder T cells developing in a responder environment become phenotypic GAT-responders, I-Aq B cells remain unresponsive to GAT, even after maturation in a GAT-responder animal. Conversely, (B10.A x B10.Q)F1 ([GAT responder x GAT nonresponder]F1) T cells developing in a B10.Q GAT nonresponder host fail to respond to GAT, but F1 B cells from the same F1 leads to parent chimeras make excellent proliferative responses in the presence of GAT and responder T cells. Thus, by this assay, B cell immune response gene function is genetically determined and is not affected by the developmental milieu.
mesh_terms: D000818:Animals; D000941:Antigens / Q000008:administration & dosage; D001402:B-Lymphocytes / Q000276:immunology*; D001853:Bone Marrow / Q000528:radiation effects; D005802:Genes, MHC Class II; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D010455:Peptides / Q000276:immunology; D010641:Phenotype; D011108:Polymers; D011828:Radiation Chimera; D013601:T-Lymphocytes / Q000276:immunology; D014373:Tuberculin / Q000276:immunology
chemical_list: D000941:Antigens; D010455:Peptides; D011108:Polymers; D014373:Tuberculin; C020749:GAT