[Ultrastructural investigations on the effect of cyclophosphamide on experimental Trypanosoma cruzi infections (author's transl)].
Strains of low virulent Trypanosoma cruzi are difficult to maintain in experimental hosts, but they can be activated by the immunosuppressive effects of cyclophosphamide (CY), a cancer chemotherapeutic agent. An attempt, using electron microscopy, to find out whether CY had any effect on the morphology of the bloodstream forms of the parasite failed to detect any differences when those from CY-treated hosts were compared with those from controls.
D000818:Animals; D001769:Blood / Q000469:parasitology; D014355:Chagas Disease / Q000469:parasitology*; D003520:Cyclophosphamide / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008854:Microscopy, Electron; D009940:Organoids / Q000648:ultrastructure; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000648:ultrastructure
D003520:Cyclophosphamide
Ultrastrukturelle Untersuchungen zum Einfluss von Cyclophosphamid auf experimentelle Trypanosoma cruzi-Infektionen.