Hallucinogens as discriminative stimuli: a comparison of 4-OMe DMT and 5-OMe DMT with their methythio counterparts.
Rats, trained to discriminate 1.5 mg/kg of the hallucinogenic agent 5-methoxy-N,N-dimethyltryptamine (5-OMe DMT) from saline in a two-lever drug discrimination task, were challenged with various doses of the 4-methoxy, 4-methylthio and 5-methylthio derivatives of DMT. The 5-OMe DMT cue was found to generalize to all three of these agents; the order of potency is 5-OMe greater than 5-SMe greater than 4-OMe greater than 4-SMe DMT.
D000818:Animals; D004192:Discrimination, Psychological / Q000187:drug effects*; D005795:Generalization, Stimulus; D006213:Hallucinogens / Q000494:pharmacology*; D007536:Isomerism; D008297:Male; D008732:Methoxydimethyltryptamines / Q000494:pharmacology*; D004130:N,N-Dimethyltryptamine / Q000031:analogs & derivatives / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000031:analogs & derivatives*; D013329:Structure-Activity Relationship
D006213:Hallucinogens; D008732:Methoxydimethyltryptamines; C033933:4-methylthiodimethyltryptamine; D012701:Serotonin; C033934:5-methylthiodimethyltryptamine; D004130:N,N-Dimethyltryptamine