Inhibin in the human prostate.
"Inhibin"-like protein, partially purified from the human prostate, was similar to that obtained from human seminal plasma under identical conditions. Concentration of inhibin in human prostate was tenfold higher as compared to human testis and was active biologically and immunologically. The presence of a high amount of inhibin in prostate seems to be unique in humans. Further inhibin concentration in benign prostatic hypertrophy tissue increased by tenfold in comparison to normal or cancerous tissue. Hence determination of serum level of inhibin may be used as a therapeutic tool to monitor prostate diseases.
D000818:Animals; D002369:Castration; D002850:Chromatography, Gel; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000037:antagonists & inhibitors; D006801:Humans; D007265:Inhibins; D008297:Male; D011467:Prostate / Q000032:analysis*; D011471:Prostatic Neoplasms / Q000032:analysis*; D011506:Proteins / Q000032:analysis*; D011863:Radioimmunoassay; D051381:Rats; D012661:Semen / Q000032:analysis; D013735:Testicular Hormones / Q000032:analysis*
D011506:Proteins; D013735:Testicular Hormones; D007987:Gonadotropin-Releasing Hormone; D007265:Inhibins; D005640:Follicle Stimulating Hormone