title: A study of growth hormone release in man after oral administration of amino acids.
abstract: A study was carried out in 15 male volunteers to evaluate qualitatively the secretion of growth factors following stimulation by oral amino acids. The results showed that oral administration of a combination of two amino acids (1200 mg 1-lysine plus 1200 mg 1-arginine) provoked a release of pituitary somatotropin and insulin. This phenomenon was reproducible and the growth hormone secreted in response to this stimulation had biological activity (as demonstrated by a radioreceptor assay and somatomedin induction). The effect appeared to be specific to the combination of the two amino acids; neither of the amino acids demonstrated appreciable stimulating activity when administered alone, even at the same doses.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001120:Arginine / Q000494:pharmacology*; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood*; D008239:Lysine / Q000494:pharmacology*; D008297:Male; D011863:Radioimmunoassay; D011869:Radioligand Assay; D013997:Time Factors
chemical_list: D007328:Insulin; D013006:Growth Hormone; D001120:Arginine; D008239:Lysine