title: Selective blockade of the discriminative stimulus effects of pentobarbital in pigeons.
abstract: The ability of CNS stimulants to block the discriminative effects of pentobarbital was studied in pigeons trained to discriminate IM pentobarbital (5 mg/kg) from saline. Pentobarbital, when administered alone, consistently produced greater than 90% pentobarbital-appropriate responding. The concomitant administration of pentobarbital and increasing doses of bemegride or pentylenetetrazol resulted in a dose-related decrease in pentobarbital-appropriate responses. In contrast, picrotoxin, another CNS stimulant, had little or no effect on pentobarbital-appropriate responding produced by pentobarbital.
mesh_terms: D000818:Animals; D001534:Bemegride / Q000494:pharmacology; D010856:Columbidae; D004192:Discrimination, Psychological / Q000187:drug effects*; D018756:GABA Antagonists; D010424:Pentobarbital / Q000494:pharmacology*; D010433:Pentylenetetrazole / Q000494:pharmacology; D010852:Picrotoxin / Q000494:pharmacology; D013268:Stimulation, Chemical
chemical_list: D001534:Bemegride; D018756:GABA Antagonists; D010424:Pentobarbital; D010433:Pentylenetetrazole; D010852:Picrotoxin