title: Map position of Igh-Oxa gene within the Igh region of the DBA/2 mouse strain.
abstract: Mice of 23 BXD recombinant inbred strains derived from the cross of C57BL/6J and DBA/2J were typed for the presence of a public idiotype found in the antibodies against the hapten phenyloxazolone (phOx) produced by DBA/2 mice. The marker is under the control of an immunoglobulin heavy-chain variable region gene, Igh-Ox. Eleven out of the 23 BXK strains shared the public idiotype with the DBA/2 progenitor, while 12 other BXD strains were negative, like the C57BL/6 progenitor. The Igh-Ox marker was inherited concordantly with allotype in all BXD strains except BXD-27, which carries the Igh-1c allotype of DBA/2 but lacks the Igh-Ox idiotype. The Igh-Ox marker was inherited concordantly with 4 other Igh-V markers (Igh-Np, Igh-Nb, Igh-Bgl, and Igh-Gte) in all BXD strains except BXD-20, which has the DBA/2 alleles at Igh-1 and Igh-Ox but resembles C57BL/6 at the other 4 markers. On the basis of these results the Igh-Ox marker is tentatively placed between Igh-C and the rest of the Igh-V markers.
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology; D001666:Binding Sites, Antibody / Q000235:genetics*; D002874:Chromosome Mapping; D003434:Crossing Over, Genetic; D005260:Female; D006238:Haploidy; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010080:Oxazoles / Q000276:immunology*; D010081:Oxazolone / Q000031:analogs & derivatives / Q000235:genetics / Q000276:immunology*; D011995:Recombination, Genetic
chemical_list: D000888:Antibodies, Anti-Idiotypic; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D010080:Oxazoles; C018361:2-phenyloxazolone; D010081:Oxazolone