title: Rates of exponential increase of serum estradiol concentrations in normal and human menopausal gonadotropin-induced cycles.
abstract: Serum unconjugated estradiol concentrations were measured daily in patients who ovulated spontaneously and in patients whose ovulations were induced with human menopausal gonadotropins. When the logarithm of the estradiol concentration was plotted against time (semi-log plot) for each patient, the plots were essentially linear, and the rates of estradiol production were similar during spontaneous and induced cycles. Based on two or three estradiol determinations, subsequent estradiol concentrations can be determined as long as the established rates of estradiol production falls within reasonable confidence limits. The slope of serum unconjugated estradiol concentrations of a patient known to have a multiple gestation due to multiple ovulations did not differ significantly from the slopes of estradiol concentrations with single pregnancies, suggesting that the follicular phase estradiol concentrations do not reflect number of dominant follicles.
mesh_terms: D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy; D008433:Mathematics; D008596:Menotropins / Q000627:therapeutic use; D010062:Ovulation Induction
chemical_list: D004958:Estradiol; D008596:Menotropins