Mean wall thickness and formation periods of trabecular bone packets in idiopathic osteoporosis.
The mean wall thickness (MWT) and duration of formation periods (sigma f) of trabecular bone packets have been measured in iliac crest biopsies following double tetracycline labeling from 9 women having primary osteoporosis, with vertebral crush fractures and reduced trabecular bone volume (TBV), and 9 age- and sex-matched controls. The MWT of the osteoporotic biopsies was significantly less than that of the controls and was negatively correlated with age in the latter. There was also a positive correlation between MWT and TBV in the controls but not in the osteoporotics. Sigma f, in days, showed a tendency to decline with age in the control biopsies and was further decreased in the osteoporotic patients. These results suggest that a major contribution to the negative skeletal balance existing in both primary osteoporosis and physiological osteopenia is a decrease in bone formation, caused by a reduction in the life span of the osteoblastic population at the basic multicellular unit (BMU) level.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001842:Bone and Bones / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007085:Ilium / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000378:metabolism; D010012:Osteogenesis; D010024:Osteoporosis / Q000378:metabolism / Q000473:pathology*; D013752:Tetracycline
D008903:Minerals; D013752:Tetracycline