UDP-glucuronyltransferase activities of rabbit liver microsomes for cannabinoids.
UDP-glucuronyltransferase activities for delta 8-tetrahydrocannabinol, 11-hydroxy-delta 8-tetrahydrocannabinol, cannabidiol and cannabinol were examined using liver microsomes of rabbits. The activities for cannabidiol and cannabinol were 2.5 and 19 times higher, respectively, than those for delta 8-tetrahydrocannabinol and 11-hydroxy-delta 8-tetrahydrocannabinol. Thus, the present study supports the view that glucuronide formation plays an important role in the metabolism of cannabinol, but does only a minor role in that of delta 8-tetrahydrocannabinol and 11-hydroxy-delta 8-tetrahydrocannabinol.
D000818:Animals; D002186:Cannabinoids / Q000378:metabolism*; D005965:Glucuronates / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism*; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000201:enzymology*; D011817:Rabbits
D002186:Cannabinoids; D005965:Glucuronates; D014453:Glucuronosyltransferase