Differential influence of lipoproteins isolated from women and men on the activity of the PGI2 synthetase activity.
We have found a correlation between the activity of the PGI2 synthetase in the microsomal fraction of pig aorta and the amount of high density lipoprotein (HDL) cholesterol in the incubation fluid. The reverse was true for low density lipoprotein (LDL) cholesterol. These correlations exist independently of whether the lipoproteins were isolated from men than from women as it is for HDL isolated from women than from men. This result may give an explanation for the differential risk against the incidence of cardiovascular disease between women and men at the same concentration of the individual lipoproteins in their blood.
D000818:Animals; D001011:Aorta / Q000201:enzymology; D002784:Cholesterol / Q000494:pharmacology*; D011464:Epoprostenol; D005260:Female; D006801:Humans; D008075:Lipoproteins, HDL / Q000494:pharmacology*; D008077:Lipoproteins, LDL / Q000494:pharmacology; D008297:Male; D008861:Microsomes / Q000201:enzymology; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D012737:Sex Factors; D013552:Swine / Q000378:metabolism
D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D002784:Cholesterol; D011464:Epoprostenol; D011451:Prostaglandin-Endoperoxide Synthases