Complete parenteral nutrition in the surgery of the newborn infant.
A regimen of complete parenteral nutrition (CPN), including glucose, amino acids, fat, water- and fat-soluble vitamins and minerals, was used in 10 newborn infants operated on for gastrointestinal malformations. By giving more than 90 kcal/kg/day (376 kJ) and approximately 2.1 g amino acids/kg/day, normal weight gain and nitrogen retention were obtained. 3-Methylhistidine excretion was measured in 4 infants and a correlation to the nitrogen retention was found. Normal fat clearance rates, triglyceride and cholesterol concentrations in serum were measured in all infants except in one pre-term. One preterm infant had very low levels of zinc in serum and red cells and had clinical signs of zinc deficiency. The regimen seemed to suit full-term infants very well but it is possible that even more energy should be supplied to pre-term infants and perhaps also different amounts of trace elements.
D000136:Acid-Base Equilibrium; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002784:Cholesterol / Q000097:blood; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000378:metabolism / Q000601:surgery* / Q000628:therapy; D008099:Liver / Q000201:enzymology; D008762:Methylhistidines / Q000652:urine; D009584:Nitrogen / Q000378:metabolism; D010288:Parenteral Nutrition; D010289:Parenteral Nutrition, Total; D010976:Platelet Count; D014280:Triglycerides / Q000097:blood
D008762:Methylhistidines; D014280:Triglycerides; D002784:Cholesterol; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D005947:Glucose; D009584:Nitrogen; D001663:Bilirubin