Acute dieldrin toxicity: effect on the uptake of glucose and leucine and on brush border enzymes in monkey intestine.
Administration of a single oral dose of dieldrin (20 mg/kg body wt.) to rhesus monkeys considerably elevated the uptake of glucose and the activities of brush border sucrase, lactase, maltase and alkaline phosphatase in intestine compared to control animals. Leucine uptake and leucine amino peptidase activity was significantly depressed in pesticide-treated animals. Kinetic studies with brush border sucrase revealed that augmentation of enzyme activity in pesticide-fed animals was due to an increase in the disaccharidase content.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology*; D004026:Dieldrin / Q000633:toxicity*; D005947:Glucose / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism*; D007931:Leucyl Aminopeptidase / Q000378:metabolism; D008253:Macaca mulatta; D008871:Microvilli / Q000201:enzymology*; D013393:Sucrase / Q000378:metabolism; D000520:alpha-Glucosidases / Q000378:metabolism; D001616:beta-Galactosidase / Q000378:metabolism
D000469:Alkaline Phosphatase; D000520:alpha-Glucosidases; D001616:beta-Galactosidase; D013393:Sucrase; D007931:Leucyl Aminopeptidase; D007930:Leucine; D004026:Dieldrin; D005947:Glucose