Ascorbic acid enhances the cytotoxic effect of 6-hydroxydopamine for human neuroblastoma cell lines.
Determination of LD50 values showed 3 human neuroblastoma cell lines to be 2-8-fold more sensitive to 6-hydroxydopamine (6-OHDA) than a mouse sarcoma cell line. Treatment of the cells with 6-OHDA and ascorbic acid decreased the cytotoxicity of 6-OHDA for the sarcoma cells and increased cytotoxicity for the 3 neuroblastoma cell lines.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D002460:Cell Line; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D006801:Humans; D006892:Hydroxydopamines / Q000494:pharmacology*; D051379:Mice; D009374:Neoplasms, Experimental; D009447:Neuroblastoma / Q000188:drug therapy* / Q000473:pathology; D016627:Oxidopamine; D012509:Sarcoma / Q000473:pathology
D006892:Hydroxydopamines; D016627:Oxidopamine; D001205:Ascorbic Acid