title: A preliminary double-blind study on the efficacy of carbamazepine in prophylaxis of manic-depressive illness.
abstract: A preliminary double-blind controlled study on the prophylactic effect of carbamazepine on recurrent manic-depressive psychotics was conducted with 22 patients using an inert placebo in ten subjects as a control drug. Carbamazepine in the dosage of 200-600 mg was administered for 1 year. Among the 22 carbamazepine subjects, carbamazepine was found to be effective in 60% of the cases and inert placebo in 22.2% (U-test, P less than 0.10). It is suggested that carbamazepine is a useful drug for the prophylaxis of manic-depressive illness.
mesh_terms: D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000517:prevention & control*; D002220:Carbamazepine / Q000627:therapeutic use*; D004311:Double-Blind Method; D004341:Drug Evaluation; D006801:Humans; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
chemical_list: D002220:Carbamazepine