The effect of food on the oral absorption of penicillin V preparations in children.
The oral absorption of pc V in different preparations, given at various times before and after a meal, was investigated in children with upper respiratory infections. The best absorption with respect to peak concentration was observed when potassium pc V (Calciopen) was given after at least two hours of fasting with no food intake within the following hour. Shorter periods of fasting (1, 1/2, 0 hrs) before drug intake resulted in significantly lower plasma concentrations. When drug intake was followed by a meal, the absorption was also decreased to some extent. When pc V was given in an oil suspension (Fenoxypen), or in a small volume (Roscopenin) together with a meal, the peak concentration was significantly lower than when pc V was given in an aqueous solution with a larger volume (Calciopen).
D000284:Administration, Oral; D002675:Child, Preschool; D005502:Food; D006801:Humans; D007223:Infant; D007408:Intestinal Absorption; D010404:Penicillin V / Q000008:administration & dosage / Q000378:metabolism*; D012996:Solutions; D013535:Suspensions
D012996:Solutions; D013535:Suspensions; D010404:Penicillin V