[Alpha-N-Acetylgalactosaminyl transferase activity in mucous ovarian tumors obtained from blood group O2 patients (author's transl)].
We have demonstrated, by the transfer of (1-14C) GalN Ac from exogenous UDP[ (1-14C) GalN Ac into a glycopeptide H-acceptor, the presence of an alpha-N-acetylgalactosaminyltransferase in the wall and fluid of ovarian tumors. The transfer occurs in the absence of exogenous acceptor but to a greater degree in the tumor wall and fluid obtained from blood group O patients, thereby indicating the presence of preferential endogenous acceptor(s) in tumors of these subjects.
D000017:ABO Blood-Group System; D005260:Female; D005700:Galactosyltransferases / Q000378:metabolism*; D006020:Glycopeptides / Q000096:biosynthesis; D006801:Humans; D017350:N-Acetylgalactosaminyltransferases; D010051:Ovarian Neoplasms / Q000201:enzymology* / Q000378:metabolism; D013379:Substrate Specificity
D000017:ABO Blood-Group System; D006020:Glycopeptides; D005700:Galactosyltransferases; D017350:N-Acetylgalactosaminyltransferases; C003742:UDPgalactosamine-galactose acetylgalactosaminyltransferase
Mise en èvidence d'une activité alpha-N-acetylgalactosaminyl-transfèrase dans les tumeurs secrétantes de sujets de groupe érythrocytaire O2.