Phagocytosis and killing of cefazolin-exposed Staphylococci and Bacilli by mouse peritoneal macrophages.
The phagocytic and microbicidal capacity of proteose peptone-induced macrophages from Balb/c mice was assessed in vitro against Staphylococcus aureus and Bacillus subtilis in the presence of a subinhibitory concentration of cefazolin. Enhanced phagocytosis (50-60%) and a similar killing effect (99%) after two hours, incubation was noted towards both test organisms. Electron microscopy showed phagocytic activity on both control and antibiotic-treated strains. Since cefazolin does not penetrate macrophages, the peritoneal cell morphology and ultrastructure were unaffected by the drug.
D000818:Animals; D001412:Bacillus subtilis / Q000187:drug effects; D002437:Cefazolin / Q000494:pharmacology*; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010587:Phagocytosis / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects; D013997:Time Factors
D002437:Cefazolin