[Effect of tribenol on the activity of certain redox enzymes in inflamed venous walls].
A study was made on the mechanism of action of the antivaricose agent tribenol (ethyl-3,5,6-tri-O-benzyl-D-glucofuranozide; glivenol) on the activity of hydroxyreductase on the Krebs cycle and glycolysis during occlusion of the femoral vein and its inflammation in rats. It was shown histochemically that on the 5th day of traumatic phlebitis after ligation of the vein, its wall shows a substantial rise in the activity of succinate- and malate dehydrogenase (SDH and MDH), a slight increase in the activity of lactate dehydrogenase (LDH) and a pronounced lowering of the activity of alpha-glycerophosphate dehydrogenase (alpha-GPDH). The treatment with tribenol in a dose of 25 mg/kg for 5 days makes the activity of SDH and alpha-GPDH return to normal, drastically increases the activity of LDH and produces no significant effect on MDH. In a dose of 250 mg/kg tribenol makes the activity of all hydroxyreductases studied return to normal or reduces it.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use*; D005260:Female; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D006027:Glycosides / Q000627:therapeutic use*; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism*; D010689:Phlebitis / Q000188:drug therapy* / Q000201:enzymology; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014680:Veins / Q000201:enzymology*
D000893:Anti-Inflammatory Agents; D006027:Glycosides; D010088:Oxidoreductases; D005993:Glycerolphosphate Dehydrogenase; D007770:L-Lactate Dehydrogenase; D013385:Succinate Dehydrogenase; C100302:tribenoside
Vliianie tribenola n aktivnost' nekotorykh okislitel'no-vosstanovitel'nykh fermentov v venoznoĭ stenke pri ee vospalenii.