Hemodynamic effects of intravenous fat emulsions in patients with heart disease.
Two intravenous fat emulsions (Liposyn 10%, Abbott Laboratories, North Chicago, IL, and Intralipid 10%, Cutter Laboratories, Berkeley, CA) were evaluated in 13 adult patients following cardiopulmonary bypass procedures in a randomized, prospective, double-blind study to determine their overall hemodynamic effects. The fat emulsions were administered for 30 minutes, and each patient was his own control. Neither intravenous fat emulsion was observed to exert significant changes in left ventricular stroke work, left ventricular filling pressure, cardiac output, systemic vascular resistance, mean systemic arterial blood pressure, central venous pressure, or mean pulmonary artery pressure. This study confirmed that the administration of 10% fat emulsions available in the United States does not exert significant untoward hemodynamic changes, even in patients with severe cardiac impairment recovering from recent open heart surgery.
D002315:Cardiopulmonary Bypass; D004311:Double-Blind Method; D005217:Fat Emulsions, Intravenous / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006331:Heart Diseases / Q000628:therapy*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008297:Male; D010288:Parenteral Nutrition / Q000592:standards*; D010289:Parenteral Nutrition, Total / Q000592:standards*; D011446:Prospective Studies; D012450:Safflower Oil; D013025:Glycine max
D005217:Fat Emulsions, Intravenous; D012450:Safflower Oil