title: Testicular leydig cell hyperplasia as a cause of familial sexual precocity.
abstract: Testicular Leydig cell hyperplasia was observed in two brothers presenting with progressive sexual precocity at 2 yr of age. Virilization was shown to result from increased secretion rather than decreased clearance of gonadal testosterone. Testosterone hypersecretion appeared to be gonadotropin independent, as basal and gonadotropin-releasing hormone-induced serum LH concentrations were low by both RIA and bioassay. Adrenal steroidogenesis was demonstrated to be normal by ACTH stimulation, dexamethasone suppression, and split adrenal venous function tests. Testicular histology revealed immature reproductive structures in the 2 yr old, but advanced spermatogenesis in the 3 yr-old brother. The etiology of both Leydig cell hyperplasia and reproductive testicular maturation in the absence of significant gonadotropin secretion remains to be established.
mesh_terms: D002675:Child, Preschool; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D006801:Humans; D006965:Hyperplasia / Q000150:complications; D007985:Leydig Cells / Q000473:pathology*; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D011629:Puberty, Precocious / Q000209:etiology / Q000235:genetics* / Q000378:metabolism; D013737:Testis / Q000473:pathology; D013739:Testosterone / Q000378:metabolism
chemical_list: D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone