Comparison of TRH and anorexigenic peptide on food intake and gastrointestinal secretions.
Thyrotropin releasing hormone (TRH), distributed throughout the gastrointestinal tract, and anorexigenic peptide (AP), isolated recently from the urine of females with "hypothalamic" anorexia nervosa, have been shown to affect food intake but no study has been performed to compare their action on gastrointestinal secretions. This report shows that both TRH and AP reduce dose-dependently the food intake during sham-feeding and inhibit gastric and pancreatic secretions in response to various exogenous and endogenous stimulants in conscious dogs. The results indicate that TRH and AP have similar inhibitory action on feeding and gastrointestinal secretory activity and that they may be involved in peptidergic mediation of satiety and gastrointestinal secretion.
D000818:Animals; D000856:Anorexia Nervosa / Q000652:urine; D001067:Appetite Depressants; D001639:Bicarbonates / Q000097:blood; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D006801:Humans; D007328:Insulin / Q000097:blood; D009842:Oligopeptides / Q000494:pharmacology*; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010434:Pepsin A / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D001067:Appetite Depressants; D001639:Bicarbonates; D005755:Gastrins; D007328:Insulin; D009842:Oligopeptides; D011506:Proteins; D013973:Thyrotropin-Releasing Hormone; D010434:Pepsin A