Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy.
Intrahepatic cholestasis and cutaneous bullae associated with glibenclamide therapy are described in a 61-year-old diabetic patient who presented wit hypoglycaemic coma. These features have not previously been reported as side effects of glibenclamide therapy, but intrahepatic cholestasis may occur with chlorpropamide, a similar sulphonylurea agent. The mechanism of this cholestasis is not clear at present.
D001768:Blister / Q000139:chemically induced*; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced*; D003920:Diabetes Mellitus / Q000188:drug therapy; D005905:Glyburide / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged
D005905:Glyburide