Management of Hodgkin's disease in a patient with sickle cell anemia.
A right periauricular swelling developed in a 21-year-old woman with sickle cell anemia. The mass was removed and revealed Hodgkin's disease of the lymphocyte predominance type. While preparing the patient for a staging laparotomy, an allo-anti-Kell and an allo-antic-C were identified in the patient's sera. The patient's direct antiglobulin test was positive and an auto-anti-e was eluted from the patient's erythrocytes. The patient was treated with nine courses of MOPP therapy given over a nine-month period. The clinical and therapeutic implications for the management of patients with sickle cell anemia and lymphoproliferative disorders are discussed.
D000328:Adult; D000755:Anemia, Sickle Cell / Q000097:blood / Q000150:complications*; D000970:Antineoplastic Agents / Q000008:administration & dosage; D001787:Blood Group Incompatibility / Q000150:complications; D001803:Blood Transfusion; D004359:Drug Therapy, Combination; D017707:Erythrocyte Transfusion; D005260:Female; D006689:Hodgkin Disease / Q000097:blood / Q000150:complications* / Q000628:therapy; D006801:Humans; D007626:Kell Blood-Group System; D012204:Rh-Hr Blood-Group System
D000970:Antineoplastic Agents; D007626:Kell Blood-Group System; D012204:Rh-Hr Blood-Group System