title: Experimental otitis media in chinchillas. II. Comparison of the middle ear immune responses to S pneumoniae types 3 and 23.
abstract: The present study shows that two different serotypes of Streptococus pneumoniae (type 3 and 23) when inoculated through the bulla elicit distinctly different immune responses in chinchillas. The passive hemagglutination assay shows that type 3 is a better immunogen than type 23 and that type 3 primarily elicits immune responses in the middle ear. When class-specific antibody activity was measured with the red cell linked antigen-antibody reaction test, antibody activities of serum IgG to type 3 slightly declined and of effusion IgM and IgA to type 3 increased following type 3 infection, whereas following type 23 infection antibody activities of serum IgG to type 23 increased and no antibody activities of IgA and IgM to type 23 were present in the effusions.
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000917:Antibody Formation; D002682:Chinchilla / Q000276:immunology; D004195:Disease Models, Animal; D004432:Ear, Middle / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D007136:Immunoglobulins / Q000032:analysis; D010033:Otitis Media / Q000276:immunology*; D011008:Pneumococcal Infections / Q000276:immunology*
chemical_list: D000907:Antibodies, Bacterial; D007136:Immunoglobulins