[Electrophysiology of anterior pituitary cells (author's transl)].
Anterior pituitary cells in culture are excitable. As neurons or neuroendocrine cells they display action potentials either spontaneously or when depolarized. However, the ionic requirements for action potentials in endocrine cells appear to be different to those for neurons and even between the various types of endocrine cells. In anterior pituitary cells action potentials are largely calcium (Ca2+ -dependent. The involvement of Ca2+ ions in the spiking activity of anterior pituitary cells may be a determinant factor in the mechanism of secretion.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002460:Cell Line; D003035:Cobalt / Q000494:pharmacology; D007700:Kinetics; D009532:Nickel / Q000494:pharmacology; D010903:Pituitary Gland, Anterior / Q000187:drug effects / Q000502:physiology*; D010911:Pituitary Neoplasms / Q000503:physiopathology*; D011388:Prolactin / Q000378:metabolism; D051381:Rats; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D003035:Cobalt; D013973:Thyrotropin-Releasing Hormone; D009532:Nickel; D011388:Prolactin; D002118:Calcium
Mécanismes cellulaires de la sécrétion des hormones protéiques.