Variations of the digestive absorption kinetics of carbaryl with the nature of the vehicle.
Blood kinetics of 1-naphthyl-N-methyl[14C] carbamate were determined after intravenous injection in DMSO, and after intragastric and intraduodenal administration in DMSO, oil, gum tragacanth and milk. The acetylcholinesterase inhibition and the level of 14C-activity were both determined in the blood over various periods of time. The values of the absorption rate constants after intragastric and intraduodenal administration were found to be: 0.5 h(-1) and 7 h(-1) with DMSO, 0.6 h(-1) and 0.42 h(-1) with oil, 0.13 h(-1) and 0.22 h (-1) with gum tragacanth and 0.10 h(-1) with milk. Appearance of the toxic effect (the inhibition of the acetylcholinesterases) was closely related to the absorption rate constants which themselves depend on the administration vehicle employed.
D000818:Animals; D012721:Carbaryl / Q000008:administration & dosage / Q000378:metabolism*; D004121:Dimethyl Sulfoxide / Q000008:administration & dosage; D005260:Female; D007408:Intestinal Absorption; D007700:Kinetics; D014677:Pharmaceutical Vehicles; D051381:Rats
D014677:Pharmaceutical Vehicles; D012721:Carbaryl; D004121:Dimethyl Sulfoxide