Reversal of fungitoxicity of 8-quinolinols and their copper(II) bischelates. II. Reversal of the action of 8-quinolinol by DL-alpha-lipoic acid.
The effect of amino acids and derivatives, Krebs cycle acids and related compounds, fatty acids, and vitamins and related compounds on the toxicity of 8-quinolinol and bis(8-quinolinolato)copper(II) to Aspergillus oryzae (ATCC 1011) was studied. Only aliphatic thiol-containing compounds (cysteine, glutathione, dithioerythritol, and dithiothreitol) and DL-alpha-lipoic acid protected against 8-quinolinol but not its copper(II) bischelate. It is suggested that 8-quinolinol inhibits lipoic acid biosynthesis, and the mode of fungitoxicity of 8-quinolinol is different from that of bis(8-quinolinolato)copper(II).
D000596:Amino Acids / Q000494:pharmacology; D001230:Aspergillus / Q000187:drug effects*; D002614:Chelating Agents; D002952:Citric Acid Cycle; D003300:Copper; D003545:Cysteine / Q000494:pharmacology; D004229:Dithiothreitol / Q000494:pharmacology; D005978:Glutathione / Q000494:pharmacology; D006912:Hydroxyquinolines / Q000037:antagonists & inhibitors*; D015125:Oxyquinoline / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D008063:Thioctic Acid / Q000494:pharmacology*; D014815:Vitamins / Q000494:pharmacology
D000596:Amino Acids; D002614:Chelating Agents; D006912:Hydroxyquinolines; D014815:Vitamins; D015125:Oxyquinoline; D008063:Thioctic Acid; D003300:Copper; D005978:Glutathione; D003545:Cysteine; D004229:Dithiothreitol