[Antiviral agents and corneal epithelium cicatrisation: study in rabbits (author's transl)].
Five clinically-used antiviral drugs (3% adenine arabinoside ointment; 3% acycloguanosine ointment; 0.24% idoxuridine ointment; 1% trifluorothymidine drops) were compared with a control (petrolatum base) to determine their toxic effects on rabbit corneal epithelium after injury by iodine vapors: --Only trifluorothymidine significantly retarded healing of epithelial erosions. --Histopathologic examination after seven-day treatment showed that all five drugs, except vidarabine and to a lesser degree acycloguanosine, caused toxic changes in the regenerating epithelium.
D000212:Acyclovir; D000818:Animals; D000998:Antiviral Agents / Q000633:toxicity*; D001972:Bromodeoxycytidine / Q000031:analogs & derivatives; D003315:Cornea / Q000187:drug effects* / Q000473:pathology; D003841:Deoxycytidine / Q000031:analogs & derivatives / Q000633:toxicity; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D006147:Guanine / Q000031:analogs & derivatives / Q000633:toxicity; D007065:Idoxuridine / Q000633:toxicity; D011817:Rabbits; D014271:Trifluridine / Q000633:toxicity; D014740:Vidarabine / Q000633:toxicity; D014945:Wound Healing / Q000187:drug effects
D000998:Antiviral Agents; D003841:Deoxycytidine; D001972:Bromodeoxycytidine; C011288:ibacitabine; D006147:Guanine; D014740:Vidarabine; D007065:Idoxuridine; D014271:Trifluridine; D000212:Acyclovir
Antiviraux et cicatrisation de l'épithélium cornéen. Une étude expérimentale sur le lapin.