Limbitrol (amitriptyline plus chlordiazepoxide) revisited.
A reanalysis of 4-week data from a recently published study (Feighner et al. 1979) clearly demonstrate that in a significant subgroup of highly depressed patients who also suffer from at least moderate anxiety, significant treatment differences in favor of Limbitrol over AT were present not only after 1 or 2 weeks, but also after 4 weeks of treatment. These differences were not present in the less sick patients, a population in which AT was slightly favored. These findings suggest that not only is Limbitrol more effective than AT alone for a heterogeneous group of depressed patients with some concomitant anxiety during the early phases of treatment, but remains more effective that AT for a significant subgroup of highly depressed patients after 4 weeks of treatment.
D000328:Adult; D000639:Amitriptyline / Q000627:therapeutic use*; D001007:Anxiety / Q000188:drug therapy / Q000209:etiology; D002707:Chlordiazepoxide / Q000627:therapeutic use*; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019964:Mood Disorders / Q000150:complications / Q000188:drug therapy; D014149:Tranquilizing Agents / Q000627:therapeutic use*
D004338:Drug Combinations; D014149:Tranquilizing Agents; C001834:amitriptyline, chlordiazepoxide drug combination; D000639:Amitriptyline; D002707:Chlordiazepoxide