Metabolic activation of adriamycin by NADPH-cytochrome P-450 reductase, rat liver and heart microsomes and covalent protein binding of metabolites.
D000818:Animals; D001711:Biotransformation; D004317:Doxorubicin / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology; D011485:Protein Binding; D011506:Proteins / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D014316:Tritium
D011506:Proteins; D014316:Tritium; D004317:Doxorubicin; D009251:NADPH-Ferrihemoprotein Reductase; D010634:Phenobarbital