A primate model for enteral nutrition by tube.
To establish an animal model for the controlled study of enteral nutrition by tube, five adult chair-adapted primates (Macaca fasicularis) had gastrostomy and jejunostomy tubes placed for the delivery of a modified protein isolate diet. Following 7 days of postoperative depletion with a hypocaloric infusion of dextrose (20 kcal, 0 g N/kg/day), the animals were repleted for 10 days with tube feedings (124 kcal, 0.73 g N/kg/day). There was no operative mortality or morbidity and each animal demonstrated conversion to anabolism by significant weight gain, positive nitrogen balance, and net protein synthesis as determined by [15N]glycine protein turnover rates. Significant correlation was found between caloric intake and nitrogen balance at the level of nitrogen provided in this diet (r = 0.88, p less than 0.05). This model was found to be well suited for the surgical and nutritional techniques required for the long-term study of enteral nutrition by tube.
D000818:Animals; D004044:Dietary Proteins / Q000008:administration & dosage; D004750:Enteral Nutrition; D005526:Food, Formulated; D005947:Glucose / Q000008:administration & dosage; D007441:Intubation, Gastrointestinal; D008251:Macaca; D008252:Macaca fascicularis; D008297:Male; D009584:Nitrogen / Q000378:metabolism; D009751:Nutritional Requirements
D004044:Dietary Proteins; D005947:Glucose; D009584:Nitrogen