Combination effect with some aminoglycoside antibiotics.
Strains of resistant species -- Staphylococcus aureus and Streptococcus faecalis -- isolated from material of nosocomial infections in the surgical department of a Prague hospital were tested for combined effect with further chemotherapeutics. The same concerned Ps, aeruginosa noted, at present, by a high degree of resistance. In Ps. aeruginosa it was the combination sisomicin-carfecillin that proved a success in 50 p. c. of cases as well as that of sisomicin-doxycyclin. At the same time the authors draw attention to the possibility of antagonistic action of the combination sisomicin-chloramphenicol in a third part of the strains tested. Potentiation of the effect in Staphylococcus aureus strains was observed also in the combination sisomicin-carfecillin in more than one half of the strains tested and in case of sisomicin-doxycyclin in one third of the strains. In Streptococcus faecalis strains sisomicin was combined with amoxycillin, carbenicillin, carfecillin and doxycyclin; synergistic action being observed with all those combinations in more than one half of strains tested. No antagonism was registered in those cases. (Ta.).
D000617:Aminoglycosides / Q000494:pharmacology*; D002323:Carfecillin / Q000494:pharmacology; D002701:Chloramphenicol / Q000494:pharmacology; D004318:Doxycycline / Q000494:pharmacology; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D013293:Enterococcus faecalis / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012853:Sisomicin / Q000494:pharmacology; D013211:Staphylococcus aureus / Q000187:drug effects*
D000617:Aminoglycosides; D002701:Chloramphenicol; D002323:Carfecillin; D004318:Doxycycline; D012853:Sisomicin