title: A study of the efficacy of noxytiolin instillation as adjunctive to radiotherapy in carcinoma of the bladder: a clinical trial.
abstract: A prospective study was conducted to establish efficacy or otherwise of Noxytiolin (N-hydroxymethyl-N-methylthiorea) instilled concurrently with radical radiotherapy in bladder carcinoma, a previous pilot study having indicated an improved survival rate. A total of 242 patients participated in the trial. The four-year survival figures were compared and it is concluded that there was no significant difference between the controls and those patients treated with Noxytiolin.
mesh_terms: D000328:Adult; D000368:Aged; D002986:Clinical Trials as Topic; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009677:Noxythiolin / Q000627:therapeutic use*; D011446:Prospective Studies; D013890:Thiourea / Q000031:analogs & derivatives*; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy*
chemical_list: D009677:Noxythiolin; D013890:Thiourea