title: Analysis of antibody production induced by allogeneic tumor cells inoculated into the anterior chamber of the eye.
abstract: Humoral immune responses to alloantigens on P815 mastocytoma cells placed into the anterior chamber of murine eyes were studied. The results show that: (1) the amount of specific serum antibody produced by recipients of intracamerally injected P815 cells is directly proportional to the degree of immunogenetic disparity between the recipient and the injected cells; (2) destruction of allogeneic intraocular tumors is mediated, at least in part, by specific antibodies; and (3) retention of allogeneic tissue within the anterior chamber for 3 to 4 days after inoculation is essential to the elicitation of specific antibody formation. We conclude that alloantigens introduced into the anterior chamber are presented to the systemic immune apparatus in a very unique manner resulting in the preferential stimulation of specific antibody production without awakening specific cell-mediated immunity.
mesh_terms: D000818:Animals; D000867:Anterior Chamber; D005134:Eye Neoplasms / Q000276:immunology*; D005260:Female; D006085:Graft Survival; D006183:H-2 Antigens / Q000008:administration & dosage / Q000235:genetics / Q000276:immunology; D007275:Injections, Intravenous; D007518:Isoantibodies / Q000096:biosynthesis*; D012515:Mast-Cell Sarcoma / Q000276:immunology*; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D016038:Skin Transplantation
chemical_list: D006183:H-2 Antigens; D007518:Isoantibodies; C030036:anti-H-2 antibodies