[Changes in the proliferative activity of human breast cancer cells cultivated in vivo in diffusion chambers in response to antineoplastic agents].
A study was made of the effect of nitrosomethylurea (NMU), thiophosphamide and diazane on proliferative activity of human breast cancer cells cultured in diffusion chambers in vivo. NMU highly suppressed the proliferation of human breast cancer cells throughout the experiment. The maximum effect of diazane and thiophosphamide became apparent after 24 hours, while almost complete renewal of the proliferation was observed by the 72nd hour of culture. Diazane and NMU hold promise for clinical trials in human breast cancer.
D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D001943:Breast Neoplasms / Q000188:drug therapy*; D002277:Carcinoma / Q000188:drug therapy; D003979:Diazonium Compounds / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006801:Humans; D008770:Methylnitrosourea / Q000627:therapeutic use*; D051379:Mice; D008808:Mice, Inbred CBA; D008940:Mitotic Index; D009368:Neoplasm Transplantation; D009607:Nitrosourea Compounds / Q000627:therapeutic use*; D013386:Succinates / Q000627:therapeutic use*; D013852:Thiotepa / Q000627:therapeutic use*; D014183:Transplantation, Heterologous
D003979:Diazonium Compounds; D009607:Nitrosourea Compounds; D013386:Succinates; C000279:diazan; D008770:Methylnitrosourea; D013852:Thiotepa
Izmenenie proliferativnoĭ aktivnosti kletok raka molochnoĭ zhelezy cheloveka, kul'tiviruemykh v diffuzionnykh kamerakh in vivo, pod deĭstviem protivoopukholevykh preparatov.