The postexcitatory effects of acidic amino acids on spinal neurones.
The excitation of some neurones in the spinal cord of rats by L-glutamate and L-aspartate is followed by a period of reduced excitability. This effect is not observed after excitation by D-glutamate nor, in the case of Renshaw cells, by acetylcholine. The depressions following L-glutamate were reduced by bicuculline and those after aspartate by strychnine, suggesting that they may have been caused through decarboxylation of the excitatory amino acids to yield the inhibitory compounds gamma-aminobutyric acid and beta-alanine, respectively.
D000200:Action Potentials / Q000187:drug effects; D000596:Amino Acids / Q000378:metabolism / Q000494:pharmacology*; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects* / Q000502:physiology; D015091:beta-Alanine / Q000096:biosynthesis; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis
D000596:Amino Acids; D005971:Glutamates; D015091:beta-Alanine; D001224:Aspartic Acid; D005680:gamma-Aminobutyric Acid