title: [The effect of the infective inoculum on the development of pathological changes in the skin of chickens with Marek's disease].
abstract: Three groups of straight-run chickens were infected. The first group was infected with the homogenate of the skin of conditionally edible broilers, the second group was infected aerogenically by dust from halls with permanently high occurrence of Marek's disease, and the third with feather homogenate from experimental chickens with positive Marek's disease tests. All the chickens were killed in weekly intervals up to the age of eight weeks. The dynamics of the development of pathological changes was studied in the skin, ischiadic nerves, central lymphatic organs, and spleen in order to see whether different inocula or changes in central lymphatic organs would influence the occurrence of cutaneous and visceral lesions. The results indicate that the kind of infective inoculum does not influence the rise of cutaneous changes and that the central lymphatic organs have no substantial effect on the occurrence of the cutaneous form of Marek's disease; they are involved more significantly in the rise of changes in visceral organs. An exceptional finding was a neoplasm under the skin of the neck, histologically consisting of neoplastically proliferating lymphoid, reticular, fibrocytic and myxoid elements. The study also indicates that changes in the skin, nerves and in some cases also in bursa Fabricii are important for diagnostic practice particularly in dubious cases of Marek's disease.
mesh_terms: D000818:Animals; D002060:Bursa of Fabricius / Q000473:pathology; D002645:Chickens; D008380:Marek Disease / Q000473:pathology* / Q000635:transmission; D010525:Peripheral Nerves / Q000473:pathology; D012867:Skin / Q000473:pathology*; D013154:Spleen / Q000473:pathology; D013950:Thymus Gland / Q000473:pathology
vernacular_title: Vliv infekcního inokula na rozvoj patologichých zmén v küźi kurat pri Markovĕ chorobĕ.