Proteinuria in rheumatoid arthritis--drug-induced or amyloid?
Over a 5-year period 325 patients with rheumatoid arthritis received treatment with gold (162) or D-penicillamine (163). Thirty-eight (11.7%) developed proteinuria, which persisted in 10 patients; renal biopsies in these 10 patients revealed 6 cases of amyloid disease. These 6 cases illustrate the importance of investigation of rheumatoid patients developing proteinuria even when they are receiving potentially nephrotoxic drugs.
D000328:Adult; D000368:Aged; D000686:Amyloidosis / Q000209:etiology*; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000188:drug therapy; D006052:Gold Sodium Thiomalate / Q000009:adverse effects; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology / Q000473:pathology; D007678:Kidney Glomerulus / Q000648:ultrastructure; D008854:Microscopy, Electron; D008875:Middle Aged; D010396:Penicillamine / Q000009:adverse effects; D011507:Proteinuria / Q000139:chemically induced / Q000209:etiology*; D012189:Retrospective Studies
D006052:Gold Sodium Thiomalate; D010396:Penicillamine