Inhibition of carcinogen-induced neoplasia by sodium cyanate, tert-butyl isocyanate, and benzyl isothiocyanate administered subsequent to carcinogen exposure.
The effects of sodium cyanate, tert-butyl isocyanate, and benzyl isothiocyanate on carcinogen-induced neoplasia were studied in experiments in which the test compound was fed starting 1 week following completion of carcinogen administrations. Under these conditions, all three test compounds exerted an inhibitory effect on the occurrence of 7,12-dimethylbenz(a)anthracene-induced neoplasia of the breast of Sprague-Dawley rats. In a second experiment model, sodium cyanate inhibited the occurrence of 1,2-dimethylhydrazine-induced neoplasia of the large bowel of female CF-1 mice. Thus, a new group of compounds has been identified which has inhibitory capacities against neoplasia when given subsequent to carcinogen exposure.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors*; D000230:Adenocarcinoma / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D001551:Benz(a)Anthracenes / Q000037:antagonists & inhibitors*; D003485:Cyanates / Q000494:pharmacology*; D004127:Dimethylhydrazines / Q000037:antagonists & inhibitors*; D005260:Female; D007414:Intestinal Neoplasms / Q000139:chemically induced; D017953:Isocyanates; D017879:Isothiocyanates; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced; D008763:Methylhydrazines / Q000037:antagonists & inhibitors*; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D051381:Rats; D013861:Thiocyanates / Q000494:pharmacology*; D013997:Time Factors
D001551:Benz(a)Anthracenes; D003485:Cyanates; D004127:Dimethylhydrazines; D017953:Isocyanates; D017879:Isothiocyanates; D008763:Methylhydrazines; D013861:Thiocyanates; C031402:tert-butyl isocyanate; D015127:9,10-Dimethyl-1,2-benzanthracene; C031403:benzyl isothiocyanate