Intravenous nitroglycerin for the treatment of chronic cerebral vasoconstriction in the primate.
A primate model of chronic cerebral vasoconstriction is presented which closely approximates the human experience following subarachnoid hemorrhage. Treatment of the vasoconstriction with intravenous nitroglycerin produces a modest, but statistically significant, increase in the size of the most constricted vessels (11%, p less than 0.02) when compared with a control infusion of normal saline. The significance of these experiments is discussed.
D000818:Animals; D001921:Brain / Q000098:blood supply*; D005260:Female; D007275:Injections, Intravenous; D008253:Macaca mulatta / Q000502:physiology; D008254:Macaca nemestrina / Q000502:physiology; D008297:Male; D005996:Nitroglycerin / Q000008:administration & dosage / Q000627:therapeutic use*; D011323:Primates / Q000502:physiology*; D013345:Subarachnoid Hemorrhage / Q000150:complications; D013997:Time Factors; D014661:Vasoconstriction / Q000187:drug effects*
D005996:Nitroglycerin