Sodium cromoglycate and provocation tests in chronic urticaria.
Twenty patients with chronic urticaria exacerbated by aspirin or tartrazine were challenged with the offending substance after pre-treatment with either oral sodium cromoglycate or placebo in a double-blind, crossover study. The sequential vascular response test (SVR) described by Fisherman and Cohen 1-4 was used to assess response to challenge. Eighteen patients were protected by oral sodium cromoglycate and one by placebo, taking as a positive response an increase in the bleeding time of 100% or more over control values.
D000328:Adult; D001241:Aspirin / Q000009:adverse effects; D001760:Bleeding Time; D002908:Chronic Disease; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013645:Tartrazine / Q000009:adverse effects; D014581:Urticaria / Q000139:chemically induced / Q000188:drug therapy*
D013645:Tartrazine; D004205:Cromolyn Sodium; D001241:Aspirin