Amino acids: modifiers of xanthine oxidase activity.
L-Glutamic acid has been found to be a positive and L-lysine a negative modifier of the xanthine oxidase activity at the optimum pH (7.4) of the enzyme. Increase in pH was observed to be associated with a progressive decrease in the inhibition produced by L-lysine.
D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D005971:Glutamates / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008239:Lysine / Q000494:pharmacology; D008892:Milk / Q000201:enzymology; D014969:Xanthine Oxidase / Q000037:antagonists & inhibitors*
D000596:Amino Acids; D005971:Glutamates; D014969:Xanthine Oxidase; D008239:Lysine