[The child's intestinal ecosystem: effect of colistin (author's transl)].
A differential quantitative study of the fecal flora was used to appreciated the intestinal bacterial flora of 41 hospitalized children, with no infection and receiving no antibiotic treatment. Thus, it was possible to establish the bacterial normal profile of intestinal of hospitalized child. Because of the stability of the fecal flora in those controls, it was possible to study the effect of colistin on the intestinal ecosystem, in 21 children. Colistin per os, with intestinal nutrition and colistin IM in combination with gentamicin IM did not have any quantitative or qualitative effect on fecal flora. Colistin per os, with exclusive parenteral nutrition caused by disappearance of sensitive strains and their replacement by resistant organisms; this was followed by secondary septicaemia. This fact being a very high infectious risk, it leads us to abstain from administering colistin per os, when the intestine does not receive any food.
D000284:Administration, Oral; D003091:Colistin / Q000008:administration & dosage / Q000494:pharmacology*; D004750:Enteral Nutrition; D005243:Feces / Q000382:microbiology*; D006801:Humans; D007223:Infant; D007273:Injections, Intramuscular; D007422:Intestines / Q000382:microbiology*; D010288:Parenteral Nutrition
D003091:Colistin
Etude de l'écosystème intestinal de l'enfant. Influence de la colistine.