title: Psychomotor performance and real driving performance of outpatients receiving diazepam.
abstract: The primary aim of this study was to compare task performance in a laboratory test and real driving performance of outpatients receiving diazepam medication with those of control subjects. Plasma and saliva samples were taken to investigate a level-response relationship. Real driving performance was measured by trained observers. The design of the laboratory test was based on a vigilance task (high attention) directly followed by a simple eye-hand coordination tasks (low attention). Twenty-two males participated in the study. Diazepam was given orally by prescription, mostly as a maintenance dose of 5 mg three times a day. Patients receiving diazepam showed impaired performance in the driving test and the low-attention task. Furthermore, the results indicate no relationship between plasma or saliva levels of diazepam and/or its metabolite N-desmethyldiazepam and real driving performance and/or laboratory task performance.
mesh_terms: D000328:Adult; D001288:Attention / Q000187:drug effects*; D001334:Automobile Driving; D003975:Diazepam / Q000009:adverse effects* / Q000032:analysis / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008875:Middle Aged; D010045:Outpatients; D012463:Saliva / Q000032:analysis; D014796:Visual Perception / Q000187:drug effects
chemical_list: D003975:Diazepam