title: Changes in phosphorus distribution during total parenteral nutrition.
abstract: To investigate the mechanism of hypophosphatemia during total parenteral nutrition (TPN), changes in phosphate (P) contents in the liver and muscle of rats supported by TPN for 2 days at 270 cal/g were studied in 39 Sprague Dawley rats (200 g body weight), divided into 5 groups as follows: G-I: starved for 24 hr (n = 7); G-II: TPN (5 mEq P/1000 cal) after 24 hr starvation (n = 7); G-III: starved for 4 days (n = 7); G-IV: TPN (5 mEq P/1000 cal) after 4 days starvation (n = 9); G-V: TPN (35 mEq P/1000 cal) after 4 days starvation (n = 9). P contents of the tissues were measured colorimetrically. Results indicated that muscle P content decreased in the depleted rat supported by TPN with low P intake, while an increase in P content in the liver was a constant finding in each TPN group. Increase in P intake tended to preserve the P content in the muscle. These findings suggest that the changes in P distribution in major body tissues must be considered in addition to the changes in the serum inorganic P levels to evaluate an adequate P requirement for TPN.
mesh_terms: D000818:Animals; D001835:Body Weight; D008099:Liver / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism*; D009751:Nutritional Requirements; D010288:Parenteral Nutrition; D010289:Parenteral Nutrition, Total; D010710:Phosphates / Q000097:blood*; D010758:Phosphorus / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D013217:Starvation / Q000378:metabolism; D013997:Time Factors
chemical_list: D010710:Phosphates; D010758:Phosphorus