title: Maternal serum diamine oxidase in fetal death and low-birth-weight infants.
abstract: Serum diamine oxidase was measured at different gestational ages in 681 pregnancies resulting in live births and 102 pregnancies resulting in fetal deaths. Statistical analysis revealed that gestational age-adjusted diamine oxidase levels in the fetal-death group were significantly lower (P less than 0.001) than those in the live-birth group. Moreover, the relative risk associated with a low diamine oxidase level, compared with a normal level, increased from 3.7 at 8 weeks to 16.6 at 12 weeks. Pregnancies resulting in low-birth-weight infants exhibited normal serum diamine oxidase levels. The association between low diamine oxidase and subsequent fetal death is discussed in view of the hypothesis that polyamines and polyamine-degrading enzymes interact to protect the fetoplacental unit from immune rejection.
mesh_terms: D006631:Amine Oxidase (Copper-Containing) / Q000097:blood*; D004796:Clinical Enzyme Tests; D005260:Female; D005313:Fetal Death / Q000175:diagnosis / Q000201:enzymology*; D006801:Humans; D007231:Infant, Newborn; D007236:Infant, Small for Gestational Age; D011247:Pregnancy; D011296:Prenatal Diagnosis
chemical_list: D006631:Amine Oxidase (Copper-Containing)