Inhibition of pituitary response to gonadotropin releasing hormone by urinary gonadotropin inhibiting substance.
The effect of the partially purified urinary gonadotropin inhibiting substance (GIS) on pituitary response to stimulation with gonadotropin releasing hormone (GnRH) was studied. The biologic control of the purified substance showed that the anti-LH and anti-FSH activity of the crude urinary substance was preserved. The experiments made on intact and castrated rats previously treated for two days with GIS and stimulated with GnRH revealed that this substance caused a significant decrease in the serum level of LH and FSH but not in their pituitary content. Furthermore it lowered serum and testicular testosterone in the intact lot as against the controls. The mechanism of action of the purified urinary substance on the pituitary-testicular axis is discussed.
D000818:Animals; D002369:Castration; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D007986:Luteinizing Hormone / Q000494:pharmacology; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D010455:Peptides / Q000494:pharmacology*; D010902:Pituitary Gland / Q000187:drug effects*; D010906:Pituitary Hormone-Releasing Hormones / Q000494:pharmacology*; D051381:Rats; D014599:Uterus / Q000187:drug effects
D006063:Chorionic Gonadotropin; D010455:Peptides; D010906:Pituitary Hormone-Releasing Hormones; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone