Recovery of the in vivo cytotoxic T-cell response in cyclophosphamide-treated mice by injection of mixed-lymphocyte-culture supernatants.
Mice given injections of high antileukemic doses of cyclophosphamide lost the capacity to generate cytotoxic T-cells in vivo to allogeneic tumor cells. These low responses were not due to the elimination of cytotoxic T-lymphocyte precursors because normal cytotoxic responses were obtained in vivo after cyclophosphamide treatment by injection of helper factor derived from mixed-lymphocyte-culture supernatants.
D000818:Animals; D002460:Cell Line; D003520:Cyclophosphamide / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D007375:Interleukin-1; D007939:Leukemia L1210 / Q000276:immunology*; D008214:Lymphocytes / Q000187:drug effects* / Q000276:immunology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D011506:Proteins / Q000008:administration & dosage* / Q000276:immunology; D013997:Time Factors; D014185:Transplantation, Isogeneic
D007375:Interleukin-1; D011506:Proteins; D003520:Cyclophosphamide