title: Testicular function in strains of mice selected for differences in gonadotrophin-induced ovulation.
abstract: Mice were selected on the basis of ovulatory responses to injections of pregnant mare serum gonadotrophin (PMSG) and human chorionic gonadotrophin (hCG). Various parameters of pituitary and gonadal function as well as responsiveness to exogenous gonadotrophins were examined in males from high induced-ovulation rate (HIOV) and low induced-ovulation rate (LIOV) lines. Testicular weight, seminal vesicle weight and plasma LH levels were lower in HIOV than in LIOV males, while plasma concentrations of FSH and testosterone did not differ. Binding of FSH, but not of LH, in the testes was significantly higher in HIOV mice. Twenty-four hours after administration of hCG, plasma testosterone levels were higher and testicular LH binding sites appeared more depleted in HIOV than in LIOV males. Production of testosterone by decapsulated testes in vitro was significantly higher in HIOV than in LIOV mice under basal conditions, as well as in the presence of LH, FSH, hCG or PMSG. It was concluded that selection for differences in gonadotrophin-induced ovulation rate produced correlated differences in the steroidogenic response of the testes to gonadotrophins and that these differences may be due to divergence in the number of gonadal FSH binding sites.
mesh_terms: D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood / Q000494:pharmacology; D006064:Gonadotropins, Equine / Q000494:pharmacology*; D066298:In Vitro Techniques; D007986:Luteinizing Hormone / Q000097:blood / Q000494:pharmacology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009929:Organ Size / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects*; D013737:Testis / Q000187:drug effects / Q000502:physiology*; D013739:Testosterone / Q000096:biosynthesis / Q000097:blood
chemical_list: D006063:Chorionic Gonadotropin; D006064:Gonadotropins, Equine; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone