[Combination of beta-receptor blocking agents and saluretica in outpatient treatment of hypertension. Results of a comparative study (author's transl)].
In a randomized single-blind study a comparison was made between the blood pressure lowering effect and the tolerance of two different combinations of beta-blockers and diuretic agents, one of the combinations being given in a sustained-release form. The study was made in 60 out-patients suffering from hypertension of the severity degrees I and II (WHO). The blood pressure reduction achieved as well as the diminution of the increase in heart rate and blood pressure under ergometric load proved to be almost equal in both groups. The number of patients whose blood pressure was normalized by the end of the study was larger in the group treated with Cardiotensin. The influence on laboratory parameters was only minimal and without clinical relevance. Both preparations have generally been well tolerated and exhibited an equal duration of effect.
D001581:Benzothiadiazines / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002046:Bupranolol / Q000627:therapeutic use*; D003692:Delayed-Action Preparations / Q000627:therapeutic use; D004338:Drug Combinations / Q000627:therapeutic use; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D005082:Physical Exertion; D011412:Propanolamines / Q000627:therapeutic use*; D014223:Triamterene / Q000627:therapeutic use*
D001581:Benzothiadiazines; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D011412:Propanolamines; C025276:bemetizide, bupranolol, triamterene drug combination; D002046:Bupranolol; D014223:Triamterene
Beta-Rezeptorenblocker-Saluretika-Kombination in der ambulanten Hochdrucktherapie. Resultate einer Vergleichsstudie.