[The dynamics of the drug release from ointment bases. Part 3: The effects of some emulsifiers on the liberation of nitroglycerin (author's transl)].
The main objective of the present investigation was the pharmaceutical evaluation of the dynamics of the liberation of nitroglycerin from polyethylene bases in comparison to the lanolin-containing commercial preparation Nitrocard. By dialysis through a semipermeable membrane, using the apparatus of Elszewski and Kubis, it was found that the liberation rate from the polyethylene ointments is greater than that from the lanolin ointment, the release being dependent upon the molecular mass of the polyethylene mixtures. Cetyl alcohol and Span emulsifiers increase the liberation; white wax exerts a delaying effect. A composition is proposed which corresponds, in respect of the release of nitroglycerin, to the commercial preparation.
D004655:Emulsions; D005079:Excipients; D005996:Nitroglycerin / Q000008:administration & dosage*; D009823:Ointment Bases; D011092:Polyethylene Glycols
D004655:Emulsions; D005079:Excipients; D009823:Ointment Bases; D011092:Polyethylene Glycols; D005996:Nitroglycerin
Dynamik der Arzneimittelabgabe aus Salbengrundlagen. 3. Mitteilung: Einfluss einiger Emulgatoren auf die Liberation von Nitroglycerol.