Demethylchlortetracycline and griseofulvin as examples of specific treatment for mycosis fungoides.
Long-term control of mycosis fungoides in the tumour stage was achieved in one patient by daily demethylchlortetracycline therapy. On two occasions widespread nodules and tumours completely involuted within 1 month of initiating this therapy. A second patient showed complete resolution of his plaque stage mycosis fungoides after the institution of oral griseofulvin therapy for a chronic fungus infection. The disease reappeared upon stopping the griseofulvin and involuted upon its resumption. The observations are interpreted as evidence that reduction or eradication of a persistent bacterial or fungal antigen may have a remarkable ameliorative effect in selected mycosis fungoides patients.
D003707:Demeclocycline / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006118:Griseofulvin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009182:Mycosis Fungoides / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy*
D006118:Griseofulvin; D003707:Demeclocycline