Nucleoside changes in tRNAs from Bacillus subtilus treated with 5-fluorouracil.
Extensive amounts of 5-fluorouridine and lower levels of 5-fluorocytidine are incorporated into tRNAs from Bacillus subtilus grown in the presence of 5-fluorouracil. Nucleoside analyses revealed both pseudouridine and 5-methyl-uridine levels to be reduced more extensively at low levels of analog incorporation than could be accounted for by a stoichiometric replacement, as observed earlier with Escherichia coli.
D001412:Bacillus subtilis / Q000187:drug effects / Q000378:metabolism*; D001482:Base Composition; D005472:Fluorouracil / Q000494:pharmacology*; D012343:RNA, Transfer / Q000378:metabolism*; D012263:Ribonucleosides / Q000378:metabolism*
D012263:Ribonucleosides; D012343:RNA, Transfer; D005472:Fluorouracil