title: [Analysis of the stability and local cooperativity of DNA : elements permitting the recognition of promoters by DNA-dependent RNA polymerase].
abstract: Analysis of the local stability of promoters processed by E. Coli RNA polymerase shows that they bear a characteristic stability profile: two segments of low stability are located around --35 and --8 bases ahead of the transcription start and are generally bordered by more stable segments. This key profile may act as a recognition signal for both attracting and positioning the RNA polymerase in the promoter site.
mesh_terms: D001483:Base Sequence; D004269:DNA, Bacterial; D012321:DNA-Directed RNA Polymerases / Q000235:genetics*; D004355:Drug Stability; D004926:Escherichia coli / Q000235:genetics; D009876:Operon; D014158:Transcription, Genetic
chemical_list: D004269:DNA, Bacterial; D012321:DNA-Directed RNA Polymerases
vernacular_title: Analyse de la stabilité et de la coopérativité locale de l'ADN : éléments pouvant permettre la reconnaissance de promoteurs par l'ARN polymérase ADN dépendante.