Lithium in combination with haloperidol or thyrotropin-releasing hormone induces jumping in mice.
Lithium (250 mg/kg IP) administered in combination with haloperidol (2-5 mg/kg IP) or thyrotropin-releasing hormone (TRH) (10 or 20 mg/kg, IP) evoked jumping in mice. Jumping elicited by lithium (250 mg/kg) plus haloperidol (4 mg/kg) or TRH (20 mg/kg) was decreased by physostigmine (0.2 mg/kg IP) and phentolamine (10 mg/kg IP), but was increased by atropine (5 mg/kg IP) and clonidine (0.5 mg/kg IP). While the jumping was not affected by either methylatropine (5 mg/kg IP) or propranolol (10 mg/kg IP). Jumping was also induced by haloperidol (4 mg/kg IP), but not by lithium (250 mg/kg IP), administered after atropine (5 mg/kg IP) or clonidine (0.5 mg/kg IP). The results indicate that lithium plus haloperidol or TRH produces jumping in which dopaminergic and cholinergic inhibition as well as noradrenergic activation may be involved.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006220:Haloperidol / Q000494:pharmacology*; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009043:Motor Activity / Q000187:drug effects*; D011954:Receptors, Dopamine / Q000187:drug effects; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D011954:Receptors, Dopamine; D013973:Thyrotropin-Releasing Hormone; D001285:Atropine; D008094:Lithium; D006220:Haloperidol