The carotid bodies of spontaneously hypertensive rats (SHR): a functional and morphologic study.
The parameters of the acid-base-state of the arterial blood were measured in spontaneously hypertensive rats of the Okamoto-strain (SHR) and in normotensive Wistar rats (NWR) of a random-bred strain. The animals were anaesthetized with chloralose-urethane and breathed normal air under sea-level conditions. Structure and size of their carotid bodies were studied by light-microscopic methods. When compared with the NWR, the SHR showed a respiratory alkalosis and enlarged carotid bodies. In the SHR, never in the NWR, the lumen of the branches of the glomic arteries was narrowed by pad-like structures. The data suggest that systemic hypertension leads to morphologically and functionally detectable alterations of both carotid body structure and function. The interdependence of arterial chemoreceptor activity, sodium household, and the adjustment of systemic arterial blood pressure is briefly discussed.
D000818:Animals; D001158:Arteries / Q000473:pathology; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D002344:Carotid Body / Q000098:blood supply / Q000473:pathology / Q000503:physiopathology*; D006973:Hypertension / Q000097:blood / Q000473:pathology / Q000503:physiopathology*; D051381:Rats; D011919:Rats, Inbred Strains
D002245:Carbon Dioxide