Irradiation and gastro-intestinal fibrinolysis: an experimental study in the rat.
Tissue fibrinolysis in the rat stomach and transverse colon was studied after X-ray irradiation of the abdomen. Tissue biopsies were examined on unheated fibrin plates and with a histochemical technique modified from Todd. A significantly increased fibrinolytic activity was found in the mucosa of the stomach and colon 3 days after irradiation, while fibrinolysis localized to submucosal vessels was unchanged. Mucosal fibrinolysis in the stomach was significantly inhibited by intragastric administration of tranexamic acid.
D000818:Animals; D000933:Antifibrinolytic Agents; D004064:Digestive System / Q000473:pathology / Q000528:radiation effects*; D005342:Fibrinolysis / Q000528:radiation effects*; D005753:Gastric Mucosa / Q000528:radiation effects; D007413:Intestinal Mucosa / Q000528:radiation effects; D008297:Male; D051381:Rats; D014148:Tranexamic Acid / Q000494:pharmacology
D000933:Antifibrinolytic Agents; D014148:Tranexamic Acid