Batch-swirl method for detoxification of isopropyl myristate used for sterility testing of oils and ointments: membrane selection.
A 1-hr batch-swirl method was developed for the preparation of isopropyl myristate to be used in the sterility testing of oils and ointments. The method is simpler and faster than that in USP XX. Flow rates of various membrane filters were tested. Cellulose acetate filters increased the filtration rate of oils and ointments and, thus, reduced the exposure time of possible microbial contaminants to the toxicity of isopropyl myristate.
D004340:Drug Contamination; D006863:Hydrogen-Ion Concentration; D008567:Membranes, Artificial; D009226:Myristates / Q000494:pharmacology; D009227:Myristic Acids / Q000494:pharmacology; D009821:Oils / Q000592:standards; D009824:Ointments / Q000592:standards; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013242:Sterilization; D014462:Ultrafiltration
D008567:Membranes, Artificial; D009226:Myristates; D009227:Myristic Acids; D009821:Oils; D009824:Ointments; C008205:isopropyl myristate