Prolidase deficiency with iminodipeptiduria: biochemical investigations and first results of attempted therapy.
A 33-year-old female patient with chronic recurrent leg ulcerations was shown to present a massive iminodipeptiduria which seemed to be attributable to disturbance of collagen metabolism. Biochemical investigations confirmed an hereditary prolidase deficiency. A treatment was tried for the first time and showed a good biochemical result and a clinical improvement.
D000328:Adult; D000592:Amino Acid Metabolism, Inborn Errors / Q000188:drug therapy*; D001205:Ascorbic Acid / Q000627:therapeutic use; D004150:Dipeptidases / Q000097:blood / Q000172:deficiency*; D004151:Dipeptides / Q000652:urine*; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000031:analogs & derivatives / Q000627:therapeutic use / Q000652:urine; D008345:Manganese / Q000627:therapeutic use; D010672:Phenytoin / Q000627:therapeutic use; D011392:Proline / Q000097:blood / Q000172:deficiency / Q000652:urine
D004151:Dipeptides; D008345:Manganese; D010672:Phenytoin; C015248:glycylproline; D011392:Proline; D004150:Dipeptidases; C022449:proline dipeptidase; D001205:Ascorbic Acid; C012393:oxaceprol; D006909:Hydroxyproline