[Variability of beta-1,3/1,4-glucanglucanohydrolase-forming Streptomyces narbonensis induced by UV rays and mitomycin C].
The effect of mitomycin C and UV on spores before germination and two hours after it was investigated with Streptomyces narbonensis 2a producing beta-1,3/1,4-glucanglucan hydrolase (beta-glucanase). The lethal effect of mitomycin C on the germinating spores was considerably greater than that on the spores. The mutagenic activity of mitomycin C was closely related to the process of spore germination. The frequency of mutations was higher when mitomycin C acted on germinated spores. UV caused a lesser frequency of morphological mutations than mitomycin C did. The action of UV produced mutants which synthesized beta-glucanase of the exotype in the course of fermentation in a medium without an inductor.
D004790:Enzyme Induction / Q000187:drug effects / Q000528:radiation effects; D014644:Genetic Variation / Q000187:drug effects / Q000528:radiation effects*; D006026:Glycoside Hydrolases / Q000096:biosynthesis*; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology*; D009154:Mutation; D013171:Spores, Bacterial / Q000187:drug effects / Q000528:radiation effects; D013302:Streptomyces / Q000187:drug effects / Q000201:enzymology* / Q000528:radiation effects; D014466:Ultraviolet Rays
D008937:Mitomycins; D016685:Mitomycin; D006026:Glycoside Hydrolases; C028020:licheninase
Izmenchivost' Streptomyces narbonensis, obrazuiushchego beta-1,3/1,4-gliukangliukanogidrolazu, vyzvannaia UF-luchami i mitomitsinom C.