Suppression of calcium-induced removal of the Z-line by a thiol-protease inhibitor, E-64-c.
A new thiol-protease inhibitor, E-64-c (N-[N-(L-3-carboxyoxirane-2-carbonyl)-L-leucyl]-isoamylamine), specifically suppressed the disappearance of the Z-line terminal by calcium in rat soleus muscle. This results suggests that calcium-activated neutral protease (CANP) may be involved in such calcium-mediated degeneration of myofilaments.
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology*; D007930:Leucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009132:Muscles / Q000187:drug effects / Q000502:physiology*; D009210:Myofibrils / Q000187:drug effects / Q000502:physiology; D051381:Rats
D000001:Calcimycin; C032425:N-(N-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine; D007930:Leucine; D002118:Calcium