Tumour induction by carcinogens in iron deficient rats.
The hypothesis that the impaired delayed hypersensitivity reactions noted in humans with iron deficiency might predispose to malignant disease, has been examined in two experimental tumour situations. Dimethylbenzanthracene induced mammary tumours an methylcholanthrene induced fibrosarcomas have been studied in female Wistar rats. There is no difference between controls and animals fed on a semi-synthetic iron deficient diet when assessed by induction time, tumour size, total number of tumours, histological characteristics, or incidence of metastases. No support for the hypothesis has been found.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D005260:Female; D005354:Fibrosarcoma / Q000139:chemically induced*; D000090463:Iron Deficiencies; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D008748:Methylcholanthrene; D051381:Rats; D011919:Rats, Inbred Strains; D012513:Sarcoma, Experimental / Q000139:chemically induced
D008748:Methylcholanthrene; D015127:9,10-Dimethyl-1,2-benzanthracene