title: Antibiotic production by submerged culture of Melanconis flavovirens (Otth) Wehm.
abstract: The pyrenomycete Melanconis flavovirens under submerged cultivation produced antibiotics active against both bacteria and fungi. Glucose and corn-steep liquor were the best C and N sources for the antibiotic production, respectively. Supplementation with Tween-80 and enthylene glycol stimulated both antifungal and antibacterial antibiotic production, whereas oleic acid only the antifungal one. Addition of K2HPO4 also showed a positive effect. The optimal conditions for fermentation of the antifungal component are given.
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D001203:Ascomycota / Q000378:metabolism*; D001412:Bacillus subtilis / Q000187:drug effects; D002175:Candida / Q000187:drug effects; D002244:Carbon / Q000378:metabolism; D003470:Culture Media; D009584:Nitrogen / Q000378:metabolism; D013098:Xylariales / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D003470:Culture Media; D002244:Carbon; D009584:Nitrogen