title: Prophage-mediated production of a bacteriocinlike substance by SP beta lysogens of Bacillus subtilis.
abstract: Cultures of Bacillus subtilis lysogenic for the temperature bacteriophage SP beta release "betacin", a bacteriocinlike substance that inhibits B. subtilis strains which do not carry this phage. Production of betacin is blocked by mutations in the bet gene on the prophage and a second phage gene, tol, is apparently involved in making the lysogen itself tolerant to betacin. Mutations in a bacterial gene betR, located on the B. subtilis chromosome between metC and pyrD, render nonlysogens tolerant to betacin.
mesh_terms: D000942:Antigens, Bacterial / Q000032:analysis; D001412:Bacillus subtilis / Q000276:immunology / Q000378:metabolism*; D001430:Bacteriocins / Q000096:biosynthesis*; D001435:Bacteriophages / Q000378:metabolism*; D004352:Drug Resistance, Microbial; D008242:Lysogeny
chemical_list: D000942:Antigens, Bacterial; D001430:Bacteriocins; C029378:betacin, Bacillus subtilis