Lithium neurotoxicity in schizophrenic and schizoaffective patients. Behavioral state-related aspects of neurotoxicity.
A large variability in the rates of lithium-induced toxic-confusional states is noted in studies of lithium treatment of schizophrenic and schizoaffective patients. Treatment and subject factors which might contribute to this variability are reviewed. A greater frequency of lithium-induced toxic-confusional states is found in more acutely ill schizophrenic and schizoaffective patients. The possibility that some behavioral states may increase the risk for lithium neurotoxicity is discussed.
D000328:Adult; D003221:Confusion / Q000139:chemically induced / Q000523:psychology; D005260:Female; D006801:Humans; D008094:Lithium / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D016651:Lithium Carbonate; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000188:drug therapy*; D012306:Risk; D012559:Schizophrenia / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D019966:Substance-Related Disorders / Q000523:psychology*
D016651:Lithium Carbonate; D008094:Lithium