title: Clinical and serological differences between systemic lupus erythematosus patients with antibodies to Ro versus patients with antibodies to Ro and La.
abstract: Among 55 systemic lupus erythematosus patients having antibodies to Ro and/or La, two major groups were distinguished by titration of sera in counterimmunoelectrophoresis. The first group (30 patients) had antibodies to Ro alone. This was associated with a high incidence of antibodies to DNA (77%) and serious renal disease (53%). The second group (23 patients) had antibodies to Ro and La, and this was associated with a lower incidence of antibodies to DNA (30%) and a very low incidence of nephritis (9%). In this group a phenomenon of linkage of anti- Ro and anti-La titers was observed. Additionally two patients with only anti-La were found. Neither had clinically apparent renal disease. Thus, systemic lupus erythematosus patients with anti-Ro fall into two subgroups that differ considerably in their prevalence of anti-DNA and serious renal disease.
mesh_terms: D000941:Antigens / Q000276:immunology*; D001323:Autoantibodies / Q000302:isolation & purification*; D001324:Autoantigens / Q000276:immunology*; D003378:Counterimmunoelectrophoresis; D004247:DNA / Q000276:immunology; D006801:Humans; D005779:Immunodiffusion; D008180:Lupus Erythematosus, Systemic / Q000145:classification / Q000150:complications / Q000276:immunology*; D009393:Nephritis / Q000150:complications
chemical_list: D000941:Antigens; D001323:Autoantibodies; D001324:Autoantigens; D004247:DNA