Development of insulin-dependent diabetes mellitus during the hemolytic-uremic syndrome.
Three children developed hyperglycemia and ketoacidosis three, eight, and 60 days after the onset of hemolytic-uremic syndrome. During hyperglycemia, the two patients studied had dramatically low insulin concentrations. Circulating islet-cell and insulin antibodies were not detected. These studies suggest that pancreatic beta cell dysfunction may occur during hemolytic-uremic syndrome, and that the serum glucose concentration should be closely monitored during this disease.
D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D003920:Diabetes Mellitus / Q000209:etiology*; D016883:Diabetic Ketoacidosis / Q000209:etiology; D003981:Diazoxide / Q000627:therapeutic use; D005260:Female; D006463:Hemolytic-Uremic Syndrome / Q000097:blood / Q000150:complications* / Q000628:therapy; D006801:Humans; D006943:Hyperglycemia / Q000209:etiology; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000503:physiopathology; D010530:Peritoneal Dialysis
D001786:Blood Glucose; D007328:Insulin; D003981:Diazoxide