[Demonstration of a central hypotensive action of lysine vasopressin in the dog].
In chloralose-anaesthetized dogs intravenous infection of lysine-vasopressin (0.01 to 100 mU/kg) induced a dose-dependent increase in blood pressure and a decrease in heart rate. The same dosis injected by central (intracisternal) route induced a constant decrease in blood pressure. These results suggest the involvement of vasopressin in central cardiovascular control and in pathogenesis of some varieties of arterial hypertension.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000187:drug effects; D002946:Cisterna Magna; D003864:Depression, Chemical; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007267:Injections; D007275:Injections, Intravenous; D008236:Lypressin / Q000008:administration & dosage / Q000494:pharmacology*
D008236:Lypressin
Mise en évidence d'une action hypotensive centrale de la lysine vasopressine chez le chien.