Conversion of dihomo-gamma-linolenic acid to an isomer of leukotriene C3, oxygenated at C-8.
Mouse mastocytoma cells stimulated with ionophore A23187 and dihomo-gamma-linolenic acid produced a novel leukotriene which was characterized as 8-hydroxy-9-S-glutathionyl-10,12,14-eicosatrienoic acid (8,9-leukotriene C3).
D015126:8,11,14-Eicosatrienoic Acid / Q000031:analogs & derivatives / Q000378:metabolism*; D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D005231:Fatty Acids, Unsaturated / Q000378:metabolism*; D013058:Mass Spectrometry; D012515:Mast-Cell Sarcoma; D051379:Mice; D013189:SRS-A / Q000096:biosynthesis*; D013056:Spectrophotometry, Ultraviolet
D005231:Fatty Acids, Unsaturated; D013189:SRS-A; D000001:Calcimycin; D015126:8,11,14-Eicosatrienoic Acid