Demeclocycline in the prophylaxis of self-induced water intoxication.
Demeclocycline, a competitive inhibitor of antidiuretic hormone at renal tubules, was studied in a patient with the syndrome of psychosis, psychogenic polydipsia, and episodic water intoxication. Under double-blind, placebo-controlled conditions, demeclocycline substantially reduced the severity and frequency of hyponatremic episodes.
D000328:Adult; D003707:Demeclocycline / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007010:Hyponatremia / Q000517:prevention & control / Q000523:psychology; D007177:Inappropriate ADH Syndrome / Q000188:drug therapy; D012559:Schizophrenia / Q000150:complications*; D012565:Schizophrenic Psychology; D014869:Water Intoxication / Q000517:prevention & control* / Q000523:psychology
D003707:Demeclocycline