Clastogenicity and sister chromatid exchange induction by ftorafur.
The main effect of Ftorafur at the chromosomal level is the induction of chromatid and chromosome breaks, which is some pronounced in neoplastic or transformed cells than in normal cells. Different cell lines used in the study exhibited both in vitro and in vivo varying sensitivity to Ftorafur. Ftorafur does not increase the frequency of SCE.
D000818:Animals; D002051:Burkitt Lymphoma; D002460:Cell Line; D002875:Chromosomes / Q000187:drug effects*; D002877:Chromosomes, Human / Q000187:drug effects; D006224:Cricetinae; D003434:Crossing Over, Genetic; D046508:Culture Techniques; D005347:Fibroblasts; D005472:Fluorouracil / Q000031:analogs & derivatives*; D006801:Humans; D008214:Lymphocytes; D008325:Mammary Neoplasms, Experimental; D008545:Melanoma; D009153:Mutagens; D012854:Sister Chromatid Exchange; D005641:Tegafur / Q000494:pharmacology*
D009153:Mutagens; D005641:Tegafur; D005472:Fluorouracil