Multicenter trial of acyclovir and trifluorothymidine in herpetic keratitis.
Acyclovir 3 percent ophthalmic ointment was compared with trifluorothymidine 2 percent ointment in a double-blind trial of 59 herpes keratitis patients. Clinical progress was measured by direct clinical assessment and retrospective photographic evaluation. Ninety percent of acyclovir-treated patients and 75 percent of trifluorothymidine-treated patients had healed within 14 days. There was no significant difference in the rate of healing between the two treatment groups.
D000212:Acyclovir; D000998:Antiviral Agents / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D005260:Female; D006147:Guanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006801:Humans; D007635:Keratitis, Dendritic / Q000188:drug therapy*; D008297:Male; D013936:Thymidine / Q000031:analogs & derivatives*; D014271:Trifluridine / Q000627:therapeutic use*
D000998:Antiviral Agents; D006147:Guanine; D014271:Trifluridine; D013936:Thymidine; D000212:Acyclovir