T cell and monocyte requirements for erythropoiesis.
Progenitor cell fractions from normal human marrow have been prepared by a method that enables low numbers of cells to be cultured and results in very little T cell or monocyte contamination. The enrichment of 14- and 21-day BFU-E was similar to that for CFU-GM and the readdition of sheep red blood rosette-forming cells had no effect on BFU-E growth. The significance of the discrepancy in cellular requirements for the growth of blood and bone marrow BFU-E is discussed.
D000818:Animals; D001853:Bone Marrow / Q000254:growth & development; D002417:Cattle; D002478:Cells, Cultured; D003114:Colony-Forming Units Assay; D004920:Erythropoiesis; D006412:Hematopoietic Stem Cells / Q000502:physiology; D006801:Humans; D009000:Monocytes / Q000502:physiology*; D012756:Sheep; D013601:T-Lymphocytes / Q000502:physiology*