title: Influence of tricarboxylic acid cycle intermediates and related metabolites on the biosynthesis of aflatoxin by resting cells of Aspergillus flavus.
abstract: Resting cells of Aspergillus flavus synthesized aflatoxin from acetate as the sole carbon source after 36 h of incubation. Addition of pyruvate (5.5 mg/m) as cosubstrate to [1-14C]acetate and unlabeled acetate considerably reduced toxin production but increased the radioactivity on the tricarboxylic acid intermediates. This suggests that high tricarboxylic acid activity drastically affected toxin synthesis.
mesh_terms: D000085:Acetates / Q000378:metabolism*; D000348:Aflatoxins / Q000096:biosynthesis*; D001231:Aspergillus flavus / Q000378:metabolism*; D002952:Citric Acid Cycle; D005650:Fumarates / Q000494:pharmacology; D008293:Malates / Q000494:pharmacology; D011773:Pyruvates / Q000494:pharmacology; D019289:Pyruvic Acid
chemical_list: D000085:Acetates; D000348:Aflatoxins; D005650:Fumarates; D008293:Malates; D011773:Pyruvates; C030298:malic acid; D019289:Pyruvic Acid