title: Poor evidence for insulin/insulin-like immunoreactivity in the CNS of lower vertebrates.
abstract: The localization of insulin/insulin-like immunoreactivity was studied in the brain and the pancreas of an amphibian (clawed frog [Xenopus laevis Daudin]) and in the CNS of two teleost fishes (bream [Abramis brama L.] and rudd [Scardinius erythrophthalmus L.] using the indirect immunofluorescence technique. With exception of cerebellar Purkinje cells no neuronal elements were found to contain insulin-like material. The frog pancreas was characterized by a strong immunofluorescence in cells producing the polypeptide.
mesh_terms: D000818:Animals; D001923:Brain Chemistry; D005399:Fishes / Q000378:metabolism*; D005455:Fluorescent Antibody Technique; D007328:Insulin / Q000032:analysis*; D008297:Male; D010179:Pancreas / Q000032:analysis; D014982:Xenopus laevis / Q000378:metabolism*
chemical_list: D007328:Insulin