title: Normal cellular and humoral immunologic parameters in the baboon (Papio ursinus) compared to human standards.
abstract: Normal adult Chacma baboons were investigated with reference to their basic immunological parameters, including serum immunoglobulin concentrations, proportions of T- and B-lymphocytes in the peripheral blood, and lymphocyte response to activators. As rabbit antihuman antisera to immunoglobulins were used for the serum immunoglobulin determinations, cross-reactivity between human and baboon immunoglobulins was evaluated, and it was found that human and baboon IgG and IgM were both completely cross-reactive, while IgA was partially cross-reactive. The serum immunoglobulin concentrations, proportions of T- and B-lymphocytes, and response to activators were found to be similar to those of man. These findings indicate that the Chacma baboon would be a useful and relevant model for the study of cellular and humoral immunology.
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D003429:Cross Reactions; D005260:Female; D006801:Humans; D005779:Immunodiffusion / Q000662:veterinary; D007136:Immunoglobulins / Q000032:analysis* / Q000276:immunology; D008213:Lymphocyte Activation; D008297:Male; D010215:Papio / Q000276:immunology*; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000166:cytology*
chemical_list: D007136:Immunoglobulins