Expression of Lyt-1 antigen on certain murine B cell lymphomas.
Although the Lyt-1 antigen has previously been considered a T cell-specific marker, recent evidence suggests that a population of Thy-1-, Lyt-1+ cells exists in normal lymphoid tissues. In this study, we have observed that the WEHI-55, WEHI-259, and CH5 B cell lymphomas express high levels of the Lyt-1 antigen, as detected by monoclonal antibodies using the fluorescence activated cell sorter. Three other B cell lymphomas of the 11 examined also gave weak but detectable reactions with the anti Lyt-1 monoclonal antibody. Except for the expression of the Lyt-1 antigen, these lymphomas are typical of cells in the B cell lineage with respect to surface phenotype. The Lyt-1 glycoprotein immunoprecipitated from metabolically labeled WEHI-55 cells is similar in structure to the Lyt-1 glycoprotein on thymocytes. These findings are similar to recent reports that B-type human lymphocytic leukemia cells express the putative human homologue of Lyt-1, the Leu-1 antigen.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002478:Cells, Cultured; D011232:Chemical Precipitation; D005455:Fluorescent Antibody Technique; D007106:Immune Sera / Q000494:pharmacology; D007138:Immunoglobulin delta-Chains; D007148:Immunoglobulin mu-Chains; D007519:Isoantigens; D008223:Lymphoma / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008814:Mice, Inbred NZB; D011817:Rabbits; D051381:Rats; D014357:Trypsin / Q000494:pharmacology
D007106:Immune Sera; D007138:Immunoglobulin delta-Chains; D007148:Immunoglobulin mu-Chains; D007519:Isoantigens; D014357:Trypsin