Acute hepatitis non-A, non-B following administration of factor VIII concentrates.
A retrospective survey on clinical hepatitis in patients with bleeding disorders was performed. Nine episodes of hepatitis non-A, non-B occurred in 8 out of 20 patients (40%) with mild hemophilia A or von Willebrand's disease, who had been treated with commercial factor VIII concentrates. Only two episodes of hepatitis B occurred during the study period. The non-A, non-B attack rate after the first treatment was 40% with factor VIII concentrate obtained from large plasma pools (= 2,000 donors) including professional plasma donors as compared to 8% after treatment with factor VIII concentrate obtained from smaller (100-250 donors) plasma pools from Scandinavian donors.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D005169:Factor VIII / Q000009:adverse effects*; D006467:Hemophilia A / Q000628:therapy; D006526:Hepatitis C / Q000635:transmission*; D006525:Hepatitis, Viral, Human / Q000635:transmission*; D006801:Humans; D008875:Middle Aged; D014842:von Willebrand Diseases / Q000628:therapy
D005169:Factor VIII