Comparative effects of indoprofen and indomethacin on rat hypothalamic prostaglandin-synthetase activity.
The inhibiting effects of indoprofen were compared with those of indomethacin on prostaglandin-synthetase activity in rat hypothalamus. A dose-dependent inhibition of PG-synthetase activity was obtained after intramuscular administration of both antiphlogistic agents; however, indoprofen was found more powerful. In conclusion, the present experiments provide additional evidence against the idea that pyrogen fever is due to the release of PG's of the E type within the hypothalamus since when comparing results obtained with the two antiphlogistic drugs used, no correlation exists between potency in inhibiting PG's synthesis and antipyretic activity.
D000818:Animals; D016861:Cyclooxygenase Inhibitors; D005334:Fever / Q000188:drug therapy; D007031:Hypothalamus / Q000201:enzymology*; D007213:Indomethacin / Q000494:pharmacology*; D007216:Indoprofen / Q000494:pharmacology*; D010666:Phenylpropionates / Q000494:pharmacology*; D051381:Rats
D016861:Cyclooxygenase Inhibitors; D010666:Phenylpropionates; D007216:Indoprofen; D007213:Indomethacin