[Coronary disease in homozygous twins. Respective roles of heredity and environment].
Two 44 year old female homozygote twins presented with cardiac ischaemia due to coronary atheroma, at 39 years of age and 43 years of age, respectively. The coronary risk factors (hypertension, cigarette smoking, hypercholesterolaemia, obesity, oral contraception) were comparable in both cases. Although presenting at different times, the electrocardiographic changes were in the same territory and coronary angiography showed a similar anatomical and lesional distribution. The literature is reviewed with respect to these cases to try to determine the respective roles of heredity and the environment in the initiation and progression of coronary atheroma.
D000328:Adult; D003327:Coronary Disease / Q000235:genetics*; D004200:Diseases in Twins; D004777:Environment; D005260:Female; D006720:Homozygote; D006801:Humans
Coronaropathie chez les jumeaux homozygotes. Rôles respectifs de l'hérédité et de l'environnement.