The effect of some antianginal drugs on the myocardial perfusion in patients with ischaemic heart disease.
78 patients with ischaemic heart disease were examined clinically and by exercise test. Their myocardial perfusion was investigated with the aid of perfusion scintigraphy using 201Tl. It was proved that the myocardial 201Tl-scintigraphy accurately detected the presence and localization of ischaemic areas in patients with IHD, with or without a history of myocardial infarction. A combined application of scintigraphy and ergometric exercise test detected with sufficient reliability the zones of transient ischaemia; this is of a great clinical value in patients with negative or equivocal results of the exercise test. The beneficial effects of nitroglycerin, Nitrong, and molsidomine (Corvaton) manifested themselves by reducing the heterogeneity of myocardial perfusion, the extent of the zone of impaired perfusion at rest, and preventing or reducing the ischaemic reaction during exercise.
D000328:Adult; D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000188:drug therapy*; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000000981:diagnostic imaging / Q000188:drug therapy*; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D003692:Delayed-Action Preparations; D006801:Humans; D008875:Middle Aged; D008981:Molsidomine; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005996:Nitroglycerin / Q000627:therapeutic use; D005082:Physical Exertion; D011877:Radionuclide Imaging; D013558:Sydnones / Q000627:therapeutic use
D003692:Delayed-Action Preparations; D013558:Sydnones; D008981:Molsidomine; D005996:Nitroglycerin