A bizarre manifestation of polyostotic fibrous dysplasia of the facial bones.
A 35-year-old white female is presented for case review. According to H. M. Worth, the classification polyostotic fibrous dysplasia, leontiasis ossea type, would be appropriate. Bone lesions are present in the skull, all facial bones, ribs, pelvic girdle and extremities. The patient's oral/maxillofacial appearance is characterized by massive bony protuberances, hypertelorism and malocclusion, resulting in a grossly distorted leonine mask-like facies. Serum alkaline phosphatase levels are high and, in spite of five facial operations, the patient's disease process continues.
D000328:Adult; D005147:Facial Bones / Q000473:pathology*; D005260:Female; D005357:Fibrous Dysplasia of Bone / Q000473:pathology*; D005359:Fibrous Dysplasia, Polyostotic / Q000473:pathology*; D006801:Humans; D008336:Mandibular Diseases / Q000473:pathology; D008439:Maxillary Diseases / Q000473:pathology; D013518:Surgery, Plastic