Promoting effect of testosterone propionate on experimental exocrine pancreatic tumors by 4-hydroxyaminoquinoline 1-oxide in rats.
A single intravenous injection of 4-hydroxyaminoquinoline 1-oxide in a dose of 9 mg/kg induced exocrine adenomas of the pancreas in a significantly higher rate in male than in female rats. Castration following HAQO administration diminished the incidence of the pancreatic tumors in male rats. A combined treatment with castration and weekly injections of testosterone propionate in a dose of 1 mg/rat after HAQO administration resulted in high incidence of the pancreatic tumors in both sexes. From these findings, it is concluded that testosterone can promote the induction of the pancreatic tumors in rats by HAQO.
D015108:4-Hydroxyaminoquinoline-1-oxide / Q000633:toxicity*; D000236:Adenoma / Q000139:chemically induced; D000634:Aminoquinolines / Q000633:toxicity*; D000818:Animals; D002369:Castration; D003043:Cocarcinogenesis; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010190:Pancreatic Neoplasms / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000502:physiology; D013739:Testosterone / Q000494:pharmacology*
D000634:Aminoquinolines; D013739:Testosterone; D015108:4-Hydroxyaminoquinoline-1-oxide