title: Mutagenicity of gamma-irradiated oxygenated and deoxygenated solutions of 2-deoxy-D-ribose and D-ribose in Salmonella typhimurium.
abstract: Solutions of 2-deoxy-D-ribose and D-ribose were gamma-irradiated under different experimental conditions and tested for mutagenicity, with and without preincubation, in Salmonella typhimurium. The irradiated sugar solutions were mutagenic in the tester strains TA100 and TA98. Except for malonaldehyde (MDA), which is not mutagenic in the concentrations produced radiolytically, the relative mutagenicities of the individual radiolytic products are unknown. With irradiated solutions of 2-deoxy-D-ribose, a relationship was found between the level of non-MDA aldehydes and the mutagenicity in TA100. Heating the irradiated solutions of 2-deoxy-D-ribose resulted in a temperature-dependent reduction of the mutagenicity. Autoclaved, non-irradiated solutions of 2-deoxy-D-ribose were not mutagenic in the Salmonella test.
mesh_terms: D000332:Aerobiosis; D000818:Animals; D001711:Biotransformation; D002470:Cell Survival / Q000187:drug effects; D003855:Deoxyribose / Q000494:pharmacology / Q000528:radiation effects*; D005720:Gamma Rays; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens; D009154:Mutation; D051381:Rats; D011919:Rats, Inbred Strains; D012266:Ribose / Q000494:pharmacology / Q000528:radiation effects*; D012486:Salmonella typhimurium / Q000187:drug effects*
chemical_list: D009153:Mutagens; D003855:Deoxyribose; D012266:Ribose