[Effect, on renal function, of a product rich in polyunsaturated fatty acids: results obtained in healthy subjects].
In 7 healthy subjects a 2,5 mg/Kg dose of i.v. phosphatidylcholine a drug with an high content of polyunsaturated fatty acids, caused variations in renal functionality as follows: a statistically significant increase of: urine flow, renal blood flow, glomerular filtration rate and sodium excretion. The above phenomena which resulted in a hypertonic poliuria, were detected during three 30 mins clearance periods. In other 5 subjects, a dose of lysine acetylsalicylate (10,5 mg/Kg) either suppressed the phenomena induced by the previous administration of phosphatidylcholine or prevented them to appear when the drug was given successively. Authors suggest that the data obtained may be ascribed to stimulation of local PG synthesis.
D001241:Aspirin / Q000031:analogs & derivatives / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000187:drug effects*; D008239:Lysine / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D010713:Phosphatidylcholines / Q000494:pharmacology; D012039:Regional Blood Flow / Q000187:drug effects; D012964:Sodium / Q000652:urine
D005231:Fatty Acids, Unsaturated; D010713:Phosphatidylcholines; D012964:Sodium; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate
Effetti sulla funzionalita renale di un prodotto ricco di acidi grassi polinsaturi: risultati ottenuti in soggetti sani.