title: Pancreatic polypeptide and vagal stimulation of gastric and pancreatic secretion in dogs.
abstract: In four dogs provided with pancreatic, gastric, and esophageal fistulae, the effects of bovine pancreatic polypeptide (BPP) infused at a physiological dose level (240 pmol per kg/hr) on gastric and pancreatic responses to sham-feeding were studied. The maximal gastric and pancreatic secretion was produced by pentagastrin and secretin, and OP-CCK infusion, respectively, with or without additions of BBP. Exogenous BPP did not change gastric acid and pepsin outputs stimulated by pentagastrin or sham-feeding, but significantly inhibited basal and maximally stimulated pancreatic protein secretion. The peak pancreatic protein, but not bicarbonate response to sham-feeding was reduced by about 31% by BPP. This reduction by BPP amounted to about 57% when the pancreas was stimulated maximally by OP-CCK. It is concluded the PP released by cephalic-vagal excitation does not affect gastric secretion, but inhibits pancreatic protein secretion, and thus might contribute to the lower pancreatic response to sham-feeding as compared with that produced by exogenous stimulants such as secretin and OP-CCK.
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D004285:Dogs; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D010179:Pancreas / Q000378:metabolism; D010189:Pancreatic Juice / Q000378:metabolism*; D010191:Pancreatic Polypeptide / Q000502:physiology*; D010434:Pepsin A / Q000378:metabolism; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D001639:Bicarbonates; D005755:Gastrins; D010191:Pancreatic Polypeptide; D010434:Pepsin A