Aging and sister chromatid exchange. VIII. Effect of the aging environment on sister chromatid exchange induction and cell cycle kinetics in Ehrlich ascites tumor cells. A brief note.
To examine the effect of an aging environment on sister chromatid exchange (SCE) induction, Ehrlich ascites tumor (EAT) cells were introduced into young and old C57BL/6J mice. Background SCE levels were not significantly different in either EAT cell or normal bone marrow cell populations between young and old animals. Despite a decline in SCE induction in EAT cells was not significantly affected by the age of the animal. These findings suggest that the aging environment may not play a major role in the diminished SCE induction observed in old cell populations.
D000375:Aging; D000818:Animals; D001854:Bone Marrow Cells; D002286:Carcinoma, Ehrlich Tumor / Q000235:genetics; D002455:Cell Division / Q000187:drug effects; D003434:Crossing Over, Genetic / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D009368:Neoplasm Transplantation; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D008937:Mitomycins; D016685:Mitomycin