Intrapartum stress lowers the concentration of high density lipoprotein cholesterol in cord plasma.
The concentration of cord plasma triglycerides, total cholesterol, high density lipoprotein (HDL) cholesterol, and apoprotein AI and AII has been measured in acidotic and non-acidotic full-term neonates without chronic maternal-fetal problems. The level of cord plasma triglycerides was significantly increased (P less than 0.05) and that of HDL cholesterol significantly decreased (P less than 0.001) in the newborns belonging to the quintile class with the lowest blood pH (less than or equal to 7.20). No differences were present between the acidotic and non-acidotic neonates in the plasma concentrations of total cholesterol or of apoprotein AI and AII. The concentration of triglycerides was increased (P less than 0.05) and that of HDL cholesterol was decreased (P less than 0.05) in the infants with the longest duration of labour. No correlation was observed between the concentration of glycerol and lipids or lipoproteins in cord plasma. The results suggest that intrapartum stress raises plasma triglycerides and induces qualitative and quantitative changes in the plasma high density lipoprotein fraction in the newborn.
D002784:Cholesterol / Q000097:blood*; D005260:Female; D005312:Fetal Blood / Q000032:analysis*; D005311:Fetal Hypoxia / Q000097:blood*; D006801:Humans; D007231:Infant, Newborn; D008071:Lipoprotein Lipase / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D011247:Pregnancy; D014280:Triglycerides / Q000097:blood
D008075:Lipoproteins, HDL; D014280:Triglycerides; D002784:Cholesterol; D008071:Lipoprotein Lipase