The individual variation in pharmacokinetics and pharmacodynamics of furosemide in young normal male subjects.
Following a 24 h control period in the ward 80 mg furosemide was injected intravenously to ten young healthy, male volunteers. The serum clearance of furosemide (Cls) was between 140 and 201 ml min-1 and on the average the renal clearance was 60% of Cls. During the initial 30 min period a maximum additional excretion rate of sodium of 3.3 mmol min-1 was reached at an excretion rate of 0.8 mg furosemide min-1. A marked initial drop in creatinine clearance (Clcr) was noted and Clcr(24 h) showed an average decrease of 12% after the drug administration. The serum concentration of potassium was decreased at 1 and 2 h after the injection and of sodium from 2 h and on. The concentration of albumin in serum increased by 3% (P less than 0.05) already after 5 min. After 2 h a maximum increase of 14% was reached. After 8 min diastolic blood pressure was increased by 13% (P less than 0.05), whereas systolic blood pressure reached a significant decrease gradually (7% after 3 h).
D000328:Adult; D000419:Albuminuria; D001794:Blood Pressure / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D005665:Furosemide / Q000097:blood* / Q000494:pharmacology* / Q000652:urine; D006801:Humans; D007677:Kidney Function Tests; D007700:Kinetics; D008297:Male; D011188:Potassium / Q000097:blood / Q000652:urine; D011485:Protein Binding / Q000187:drug effects; D012709:Serum Albumin / Q000378:metabolism; D012964:Sodium / Q000097:blood / Q000652:urine
D012709:Serum Albumin; D005665:Furosemide; D012964:Sodium; D003404:Creatinine; D011188:Potassium