title: Site of action of a ribosomal RNA methylase conferring resistance to thiostrepton.
abstract: A methylase enzyme, responsible for autoimmunity in the thiostrepton producer Streptomyces azureus, renders ribosomes completely resistant to thiostrepton. This RNA-pentose methylase modifies adenosine-1067 of Escherichia coli 23 S rRNA.
mesh_terms: D000241:Adenosine; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001483:Base Sequence; D004352:Drug Resistance, Microbial; D008780:Methyltransferases / Q000378:metabolism*; D009690:Nucleic Acid Conformation; D012335:RNA, Ribosomal; D006163:Ribonuclease T1; D012270:Ribosomes / Q000201:enzymology*; D013302:Streptomyces / Q000201:enzymology*; D013379:Substrate Specificity; D013883:Thiostrepton / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D012335:RNA, Ribosomal; D008780:Methyltransferases; C035181:rRNA (adenosine-O-2'-)methyltransferase; D006163:Ribonuclease T1; D013883:Thiostrepton; D000241:Adenosine