Mutagenicity and toxicity of aflatoxin precursors.
The Salmonella/microsome test and the chick embryo test were used to determine the mutagenicity and toxicity of five aflatoxin B1 precursors. A definite pattern emerges: the nearer the B1 an intermediate appears in the biosynthetic pathway, the more potent is its mutagenicity and toxicity.
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000096:biosynthesis / Q000633:toxicity*; D000818:Animals; D001230:Aspergillus / Q000378:metabolism; D002642:Chick Embryo; D009153:Mutagens; D012486:Salmonella typhimurium / Q000235:genetics
D000348:Aflatoxins; D009153:Mutagens; D016604:Aflatoxin B1