Evidence that the repair deficient mei-9a female in Drosophila melanogaster is a strong potentiator of chromosome loss induced in the paternal genome by dimethylnitrosamine.
From mating of Xc2/BsYy+ males treated or not with 2.5 mM DMN (dimethylnitrosamine) with repair-deficient mei-9a females or with ordinary females, induced frequencies of observed (recovered) chromosome loss were 3.69% and 0.65% and inferred (non-recovered) ring-X loss based on shifts in sex ratio (male male/female female) was 47.9% and 9.4%, respectively. Results indicate that the mei-9a female is a strong potentiator of DMN-induced chromosome damage in sperm and suggest that DMN-induced chromosome lesions are produced in substantially higher frequency in treated sperm than deducible after crosses with repair-efficient females.
D000818:Animals; D004260:DNA Repair; D004128:Dimethylnitrosamine / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D008297:Male; D009154:Mutation / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects
D004128:Dimethylnitrosamine