title: Radioactive chromium-ethylenediaminetetraacetic acid for determination of glomerular filtration rate in rabbits.
abstract: Simultaneous determination of the glomerular filtration rate was made by the insulin clearance technique and by analysis of the plasma disappearance curve of radioactive chromium-ethylenediaminetetraacetic acid (51Cr-EDTA) following an intravenous injection in 28 anaesthetized rabbits. In some rabbits, the renal function was reduced by previous surgery. The insulin clearances ranged from 2.7 to 17 ml/minute. By a double-exponential analysis of the plasma disappearance curve, the total plasma clearance of 51Cr-EDTA was found to exceed the inulin clearance by 12%. By the simpler slope-intercept analysis requiring only two blood samples, this value was 32%. The renal clearance of 51Cr-EDTA was 97% of inulin clearance. In nephrectomized rabbits, plasma clearance of 51Cr-EDTA was 0.7 ml/minute. At all levels of renal function, measurement of the plasma clearance rate of 51Cr-EDTA by the single injection technique allowed a fairly reliable estimate of the glomerular filtration rate.
mesh_terms: D000818:Animals; D001825:Body Fluid Compartments; D002860:Chromium Radioisotopes; D004492:Edetic Acid; D005919:Glomerular Filtration Rate / Q000662:veterinary*; D007444:Inulin; D007668:Kidney / Q000502:physiology; D008297:Male; D008954:Models, Biological; D009392:Nephrectomy; D011817:Rabbits / Q000502:physiology*
chemical_list: D002860:Chromium Radioisotopes; D007444:Inulin; D004492:Edetic Acid