[Decrease in the rats of intraliposomal proteolysis and labilization of rat liver lysosomes following suramin administration].
Suramin treatment (250 mg/kg bw) 24 and 48 h after administration is followed by the decreased rate of intralysosomal digestion of 14C-bovine albumin. Inhibition of proteolysis and lysosomal overloading with suramin cause the solubilization of acid hydrolases--beta-galactosidase, acid RNase, cathepsin D. There was a significant inhibition of acid phosphatase activity in the rat liver homogenate, suggesting that suramin might be used as a tool to study some features of lysosomal storage disease. Potential mechanisms of the decreased catabolic function of liver ribosomes during administration of lysosomal trophic drugs are discussed.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D002403:Cathepsins / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008247:Lysosomes / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D012260:Ribonucleases / Q000378:metabolism; D012710:Serum Albumin, Bovine / Q000378:metabolism*; D013498:Suramin / Q000494:pharmacology*; D001616:beta-Galactosidase / Q000378:metabolism
D012710:Serum Albumin, Bovine; D013498:Suramin; D012260:Ribonucleases; D000135:Acid Phosphatase; D001616:beta-Galactosidase; D002403:Cathepsins
Snizhenie skorosti vnutrilizosomnogo proteoliza i labilizatsii lizosom pecheni krys pri vvedenii suramina.