[Metabolic interactions of promethazine (author's transl)].
Owing to enzyme induction, the pretreatment of female Wistar rats with promethazine (Prothazin, Atosil) produces a shortening of the hexobarbital sleeping time, a slight increase in the relative liver weight, an increase in the N-demethylation of aminophenazone, the O-demethylation of codeine phosphate, the O-demethylation of p-nitroanisol, the glucuronidation of p-nitrophenol and the NADPH-cytochrome c reductase activity in the 9.000 g supernatant of liver homogenates. Particularly striking are the strong stimulation of the N-demethylation and the also potentiated [in contrast to the findings obtained with dioxopromethazine (Prothanon)] UDP-glucuronyltransferase activity, whereas the cytochrome P-450 concentration shows a slight trend toward increase, but this is not statistically significant. The findings obtained justify the expectation of drug interactions in case of repeated application of promethazine in the framework of a combined therapy.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005260:Female; D014453:Glucuronosyltransferase / Q000378:metabolism; D006591:Hexobarbital / Q000494:pharmacology; D008099:Liver / Q000187:drug effects; D008660:Metabolism / Q000187:drug effects*; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009251:NADPH-Ferrihemoprotein Reductase; D009929:Organ Size / Q000187:drug effects; D011398:Promethazine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D003577:Cytochrome P-450 Enzyme System; D006591:Hexobarbital; D006899:Mixed Function Oxygenases; D009251:NADPH-Ferrihemoprotein Reductase; D014453:Glucuronosyltransferase; D011398:Promethazine
Metabolische Wechselwirkungen von Promethazin 1,2.