[Inhibition of the lymphocyte response by metabolites released by the lipoxygenase of mouse macrophages].
Arachidonic acid can be transformed into a series of metabolites by the lipoxygenase enzyme activity of Mouse peritoneal macrophages. The resulting metabolites inhibit tritiated thymidine uptake by Mouse splenocytes stimulated by ConA or PHA. They suppress the development of killer cells. When mice are injected with 15-hydroperoxide, their splenocytes show a decreased H3-thymidine uptake after lectin stimulation.
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology; D003864:Depression, Chemical; D005227:Fatty Acids / Q000378:metabolism / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000187:drug effects; D008084:Lipoxygenase / Q000378:metabolism*; D008214:Lymphocytes / Q000187:drug effects*; D008264:Macrophages / Q000201:enzymology*; D051379:Mice; D010835:Phytohemagglutinins / Q000494:pharmacology
D005227:Fatty Acids; D010835:Phytohemagglutinins; D003208:Concanavalin A; D008084:Lipoxygenase
Inhibition de la réponse lymphocytaire par les métabolites libérés par la lipoxygénase des macrophages chez la souris.