Potentiation of chromosome loss induced in the paternal genome by methyl methanesulfonate and procarbazine following matings with repair deficient mei-9a females of Drosophila.
Drosophila melanogaster males carrying a ring-X (Xc2) and a doubly-marked Y chromosome (BSYy+) were treated with methylmethane sulfonate (MMS) and procarbazine, and mated with repair-deficient mei-9a females or ordinary repair-proficient females. Observed (recovered) chromosome loss were scored and nonrecovered inferred. Ring-X loss based on shifts in sex ratio were noted. Results indicate that the mei-9a female is strong potentiator of chromosome loss induced by MMS and procarbazine in line with the effect recently shown for dimethylnitrosamine (DMN)-induced chromosome lesions (Zimmering, et al 1980).
D000818:Animals; D002875:Chromosomes / Q000187:drug effects; D004260:DNA Repair; D004261:DNA Replication / Q000187:drug effects; D004331:Drosophila melanogaster / Q000235:genetics; D005260:Female; D005796:Genes / Q000187:drug effects*; D008297:Male; D008741:Methyl Methanesulfonate / Q000494:pharmacology*; D009154:Mutation; D011344:Procarbazine / Q000494:pharmacology*
D011344:Procarbazine; D008741:Methyl Methanesulfonate