title: Mutants partially defective in excision repair at five autosomal loci in Drosophila melanogaster.
abstract: Primary cell cultures derived from mutants in seventeen different genes were analyzed for their ability to excise pyrimidine dimers from DNA. Five of these mutagen-sensitive mutants [mus(2)205A1, mus(3)302D1, mus(3)304D3, mus(3)306D1, mus(3)308D2] display a significantly reduced excision capacity relative to control cultured. In addition, two of the five [mus(3)306D2, mus(3)308D2] are defective in the accumulation of single-strand breaks normally seen after ultraviolet irradiation. This study, therefore, brings the total number of Drosophila mutants known to be defective in excision repair to seven. The results are discussed relative to other genetic and biochemical properties of these mutants.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D004260:DNA Repair; D004331:Drosophila melanogaster / Q000235:genetics*; D005796:Genes; D009154:Mutation; D011740:Pyrimidine Dimers / Q000378:metabolism*
chemical_list: D011740:Pyrimidine Dimers