Effects of aspirin treatment upon fibrinolytic activity of peripheral blood granulocytes.
The effects of in vivo acetylsalicylic acid (ASA) treatment on the fibrinolytic activity of peripheral blood granulocytes have been studied in a group of healthy volunteers. Following a 4-day treatment with aspirin at a dose of 1 g/day, both the plasminogen-dependent and the nonspecific fibrinolytic activity were significantly decreased. On the contrary, no significant change in the granulocyte fibrinolytic activity was found after treatment with 250 mg ASA/day. It is suggested that the cellular release mechanism of such lytic enzymes rather than their synthesis could have been affected by the drug.
D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006098:Granulocytes / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000494:pharmacology; D010958:Plasminogen / Q000378:metabolism
D010958:Plasminogen; D010447:Peptide Hydrolases; D001241:Aspirin