[Role of pregnancy and related conditions on experimental arthritis of the rat (author's transl)].
Pregnancy in Rat induces, as in humans suffering from rheumatoid arthritis, a striking improvement of adjuvant arthritis. This improvement is not associated with an enhancement of corticosteronemia; it does not appear either in pseudo-pregnancy, or in experimental deciduoma. It could rather be related to an immune mechanism; an enhancement of T suppressor lymphocytes associated to a decrease of T helper lymphocyte activity in peripheral blood as suggested by a high response to ConA and low response PHA and PWM during arthritis plus pregnancy. The influence of hormonal factors on recirculation and/or activity of peripheral lymphocytes is not excluded.
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D001169:Arthritis, Experimental / Q000503:physiopathology; D005260:Female; D008213:Lymphocyte Activation; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D051381:Rats; D011917:Rats, Inbred Lew; D013997:Time Factors
Effet de la gestation et d'états apparentés sur la polyarthrite expérimentale du rat type Pearson.