Alveolo-arterial gradients of O2 and CO2 in hyperlipidemic subjects.
In 20 hypertriglyceridemic normocholesterolemic patients, mean age 51 years (range 42-62), +/- 10% ideal body weight, and in 18 normolipidemic controls, mean age 49 years (range 42-63), +/- 10% ideal body weight, the following tests were performed: spirometry, flow-volume curves, arterial blood gases, alveolo-capillary transfer of CO, alveolo-arterial gradients of O2 and arterio-alveolar gradients of CO2. A significant decrease in the arterial partial pressure of O2 and in the transfer of CO, with a significant increase in the alveolo-arterial gradient of O2 were found. Hypertriglyceridemia seems to compromise the alveolo-capillary gas exchange.
D000328:Adult; D000818:Animals; D002245:Carbon Dioxide / Q000097:blood* / Q000502:physiology; D004058:Diffusion; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood* / Q000502:physiology; D011650:Pulmonary Alveoli / Q000503:physiopathology; D011663:Pulmonary Surfactants / Q000096:biosynthesis; D011817:Rabbits; D051381:Rats; D014280:Triglycerides / Q000097:blood
D011663:Pulmonary Surfactants; D014280:Triglycerides; D002245:Carbon Dioxide; D010100:Oxygen