Parenteral nutrition and repeated hemodialysis of bilaterally nephrectomized conscious dogs. II. Metabolic studies.
To realize equilibrated metabolic conditions after bilateral Nx, three male mongrel dogs were exclusively fed by parenteral infusions with a dog-specific compound of EAA, glutamate, and/or glucose (0.19 g nitrogen and/or 52-70 kcal per kg and day). Daily dialyses required by infusion volumes up to 65 ml/kg/day were performed by means of a closed batch hemodialysis system (Rhodial 75) and highly permeable membranes (RP 6), which allowed a precise ultrafiltration control and direct dialysate analysis. Comparing the urea nitrogen production in a pre- and post-nephrectomy period with a 4 successive days' schedule of only glucose, followed by amino acid administration, a marked decrease of net urea nitrogen excretion was noted after nephrectomy, when EAA were supplied.
D000601:Amino Acids, Essential / Q000378:metabolism; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004044:Dietary Proteins / Q000378:metabolism; D004285:Dogs; D004734:Energy Metabolism; D008297:Male; D009392:Nephrectomy; D010288:Parenteral Nutrition; D010289:Parenteral Nutrition, Total; D006435:Renal Dialysis; D014511:Uremia / Q000378:metabolism
D000601:Amino Acids, Essential; D001786:Blood Glucose; D004044:Dietary Proteins; D003404:Creatinine