title: Analytical methods for quantitative and qualitative analysis of naltrexone and metabolites in biological fluids.
abstract: Analytical procedures for the determination of naltrexone and metabolites have been presented. The basic procedure involves the use of radiolabeled drugs and thin layer chromatography. Naltrexone, 6 beta-naltrexol and 2-hydroxy-3-O-methyl-6 beta-naltrexol were found by both the TLC procedure and combined gas chromatography-mass spectrometry. The presence of 3-O-methyl-6 beta-naltrexol was indicated by the TLC method, but this metabolite could not be found by mass spectrometry.
mesh_terms: D001826:Body Fluids / Q000032:analysis; D002855:Chromatography, Thin Layer / Q000379:methods; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D009270:Naloxone / Q000031:analogs & derivatives*; D009271:Naltrexone / Q000031:analogs & derivatives / Q000032:analysis*
chemical_list: D009270:Naloxone; D009271:Naltrexone