An unusual morphologic evolution of Paget's disease of bone.
A patient with early Paget's disease of bone was treated for 12 months with calcitonin and 10 months with etidronate. During this time the cortex of each diseased bone showed a progressive 2- to 3-fold increase in thickness. Lytic areas regressed and the new bone appeared radiographically very compact. No bowing deformity developed in 3 years of observation. This form of morphologic evolution differs markedly from those previously reported during treatment. For this patient, treatment was instituted very early during the course of the disease and moderately high doses of vitamin D were given during part of the treatment course. Observation of a larger number of patients will be needed to determine whether these factors actually modified the treatment outcome.
D002116:Calcitonin / Q000627:therapeutic use; D012968:Etidronic Acid / Q000627:therapeutic use; D005269:Femur / Q000000981:diagnostic imaging; D006801:Humans; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000473:pathology*; D010388:Pelvis / Q000000981:diagnostic imaging; D011859:Radiography
D002116:Calcitonin; D012968:Etidronic Acid