2-4-Dichloro-phenoxy-acetic acid interactions with the detoxification hepatic systems.
The present work has as aim to establish the interaction of 2-4-dichloro-phenoxy-acetic acid with the detoxification hepatic systems. The activation of the mixed function oxidase-system (MFOS) which converts the compound to a powerful arylating agent detoxified by glutathione-S-transferase was observed. The dose used do not overpass the cell adaptive capacity, tested by the serum enzymes activities, tissue lipid peroxides and glutathione concentration.
D015084:2,4-Dichlorophenoxyacetic Acid / Q000494:pharmacology*; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D005982:Glutathione Transferase / Q000378:metabolism; D008658:Inactivation, Metabolic; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D006899:Mixed Function Oxygenases / Q000378:metabolism; D051381:Rats
D008054:Lipid Peroxides; D015084:2,4-Dichlorophenoxyacetic Acid; D006899:Mixed Function Oxygenases; D005982:Glutathione Transferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase