Systemic antibiotics and gentamicin-containing bone cement in the prophylaxis of postoperative infections in total hip arthroplasty.
In a prospective controlled multicenter study, the prophylactic effect of gentamicin-containing bone cement on postoperative infections in total hip arthroplasties was compared with that of systemically given antibiotics; 812 arthroplasties were randomly assigned to an antibiotic and 821 to a gentamicin-cement group. When the patients had been followed for a period of one to two years, 13 deep infections were diagnosed in the antibiotic group and three in the gentamicin-cement group. The difference was statistically significant.
D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D001843:Bone Cements; D002986:Clinical Trials as Topic; D005500:Follow-Up Studies; D005839:Gentamicins / Q000008:administration & dosage*; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D017053:Infection Control; D007239:Infections / Q000209:etiology; D011336:Probability; D011897:Random Allocation
D000900:Anti-Bacterial Agents; D001843:Bone Cements; D005839:Gentamicins