[Effect, on renal function, of a product rich in polyunsaturated fatty acids: results obtained in subjects with chronic renal failure caused by nephroangiosclerosis].
Subjects with renal chronic failure were studied. Four patients were treated with 2,5 mg/Kg of phosphatidylcholine, a drug with an high content of polyunsatured fatty acids. The drug's effects, studied during three successive 30 min. Clearance periods, were the same as in healthy subjects, i.e.: a statistically significant increase of: urine flow, renal blood flow, glomerular filtration rate and sodium excretion. In other 6 patients, administration of i.v. lysine acetylsalicylate (10,5 mg/Kg) caused a decrease of the parameters under study, that were increasing for a previous dose of phosphatidylcholine and made ineffective another administration of this drug. If the thesis is assumed that in normal subjects phenomena may be referred to the local synthesis of PG, then the authors believe that the potential synthesis capacity of these substances is not compromised in chronic renal failure.
D000368:Aged; D001241:Aspirin / Q000031:analogs & derivatives / Q000494:pharmacology; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use*; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000098:blood supply / Q000503:physiopathology*; D007676:Kidney Failure, Chronic / Q000188:drug therapy* / Q000209:etiology; D008239:Lysine / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D009400:Nephrosclerosis / Q000150:complications / Q000188:drug therapy*; D010713:Phosphatidylcholines / Q000627:therapeutic use*; D012039:Regional Blood Flow / Q000187:drug effects; D012964:Sodium / Q000652:urine
D005231:Fatty Acids, Unsaturated; D010713:Phosphatidylcholines; D012964:Sodium; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate
Effetti sulla funzionalita' renale di un prodotto ricco di acidi grassi polinsaturi: risultati ottenuti in soggetti con insufficienza renale cronica da nefroangiosclersoi.