Serum albumin beads: an injectable, biodegradable system for the sustained release of drugs.
Biologically active compounds were entrapped in cross-linked serum albumin microbeads. Injection of these drug-impregnated beads into rabbits produced no adverse immunological reactions. Sustained release (20 days) of progesterone was demonstrated in vivo.
D000818:Animals; D003692:Delayed-Action Preparations; D005976:Glutaral; D007273:Injections, Intramuscular; D007279:Injections, Subcutaneous; D007700:Kinetics; D008297:Male; D008855:Microscopy, Electron, Scanning; D009644:Norgestrel / Q000008:administration & dosage; D011374:Progesterone / Q000008:administration & dosage* / Q000097:blood; D011817:Rabbits; D012710:Serum Albumin, Bovine / Q000008:administration & dosage*
D003692:Delayed-Action Preparations; D012710:Serum Albumin, Bovine; D009644:Norgestrel; D011374:Progesterone; D005976:Glutaral