Influence of indomethacin and aspirin on the vesicosphincteric dynamics of prostatectomized patients.
The urodynamic and clinical effects of two known prostaglandin synthetase inhibitors--indomethacin and aspirin--were analysed using 59 prostatectomized patients as experimental subjects. We obtained clinical and urodynamic results within each group by comparing the situation before and after medication. A placebo group of 12 patients was used to get an idea of the natural evolution of the situation. A urodynamic workup was done 1 h and 30 min after the administration of the drugs and placebo and the clinical results were analysed on the 8th day of treatment, at which time a few patients were again studied urodynamically. The clinical results were again evaluated a short time after the treatment had been terminated. Marked clinical and urodynamic changes showed that bladder and urethral structures had been affected. Urodynamic modifications, were statistically analysed. We concluded that changes noted were at least partially due to prostaglandin synthesis inhibition and the resulting inhibition of prostaglandin action.
D001241:Aspirin / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011448:Prostaglandin Antagonists / Q000378:metabolism; D011451:Prostaglandin-Endoperoxide Synthases / Q000494:pharmacology; D011468:Prostatectomy; D014521:Urethra / Q000187:drug effects*; D001743:Urinary Bladder / Q000187:drug effects*; D014563:Urodynamics / Q000187:drug effects
D016861:Cyclooxygenase Inhibitors; D011448:Prostaglandin Antagonists; D011451:Prostaglandin-Endoperoxide Synthases; D001241:Aspirin; D007213:Indomethacin