[Amyloidosis in a mixed pattern. Sensitivity to colchicine and melphalan].
The Authors describe a case of systemic amyloidosis with hepatic renal, intestinal and presumably cardiac involvement in the course of multiple myeloma (light K chain type). Notwithstanding the presumptions of the pathogenesis of amyloidosis and the capacity of colchicine to inhibit amyloid synthesis in rats treated with casein, the form in question derived little benefit from the association of colchicine (0.5 mg t.i.d.) and Melphalan (cycles of 4 days every 6 weeks - 0.25 mg/Kg/die).
D000686:Amyloidosis / Q000188:drug therapy* / Q000209:etiology; D003078:Colchicine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007145:Immunoglobulin kappa-Chains; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008558:Melphalan / Q000627:therapeutic use*; D008875:Middle Aged; D009101:Multiple Myeloma / Q000150:complications*; D012007:Rectum / Q000473:pathology
D007145:Immunoglobulin kappa-Chains; D008558:Melphalan; D003078:Colchicine
Amiloidosi a pattern misto. Sensibilità a colchicina + melphalan.