Blood-brain barrier permeability of L-dopa in man.
The permeability of L-dopa across the blood-brain barrier was studied in twelve patients by means of the indicator dilution method. The extraction of [1-14C]L-dopa and [3-14C]L-dopa was 11.7% and 10.4%, respectively. After pretreatment with carbidopa the extraction was unchanged (13.5% and 11.6%). The permeability coefficient (P) was calculated to 0.9 x 10(-5) cm s-1.
D000328:Adult; D000368:Aged; D001812:Blood-Brain Barrier; D002199:Capillary Permeability; D002230:Carbidopa / Q000494:pharmacology; D002250:Carbon Radioisotopes; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D007980:Levodopa / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011865:Radioisotope Dilution Technique
D002250:Carbon Radioisotopes; D007980:Levodopa; D002230:Carbidopa