Mutagenicity of N-acylglycinohydroxamic acids and related compounds.
The mutagenic activity of twenty-nine new N-acylglycinohydroxamic acids and related compounds was tested on Bacillus subtilis (Rec(+), Rec(-)) and Salmonella typhimurium (TA 98, TA 100). All the N-(substituted-benzoyl)glycinohydroxamic acids, except 3-acetylaminobenzoyl-derivative, were shown to be mutagenic to both test bacteria, whereas most of the N-aliphatic acylglycinohydroxamic acids were found to be non-mutagenic. In the present study, we discussed out observations focussing on the structure-activity correlation between their chemical structures and mutagenic activities.
D001412:Bacillus subtilis / Q000235:genetics; D006877:Hydroxamic Acids / Q000633:toxicity*; D009153:Mutagens; D011995:Recombination, Genetic / Q000187:drug effects; D012486:Salmonella typhimurium / Q000235:genetics
D006877:Hydroxamic Acids; D009153:Mutagens