[Cardiac ischemia on exercise. Effect of nifedipine and acebutolol singly and in combination (author's transl)].
In a double placebo-controlled, partly single blind and partly double blind ergometric trial, the acute action of acebutolol and nifedipine singly and in combination on cardiovascular parameters and ischemic reactions was studied. Neither nifedipine nor acebutolol lowered the resting heart rate nor the resting blood pressure significantly. At the highest load the heart rate, systolic blood pressure and the pressure-frequency product were significantly reduced, the changes due to acebutolol being more marked than those of nifedipine. nifedipine alone reduced the ST segment by 1/3, acebutolol by a half. The combined administration of acebutolol and nifedipine produced without exception significant reductions of heart rate, blood pressure, pressure-frequency product, ST segment, and ischemic pain as compared with placebo.
D000070:Acebutolol / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D001794:Blood Pressure / Q000187:drug effects; D003327:Coronary Disease / Q000188:drug therapy*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D005082:Physical Exertion; D011725:Pyridines / Q000627:therapeutic use*
D011725:Pyridines; D000070:Acebutolol; D009543:Nifedipine
Belastungs-Ischämie des Herzens. Wirkung von Nifedipin und Acebutolol einzeln und in Kombination.