title: Inhibition of diamine oxidase by antimalarial drugs.
abstract: The antimalarial drugs amodiaquine, quinacrine and chloroquine inhibit the catabolism of putrescine by the rat. Amodiaquine, the most potent of the three, does so in a dose-dependent fashion. This is attributed to the action in vivo of the drugs on diamine oxidase, an enzyme that is inhibited by them in vitro.
mesh_terms: D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors*; D000655:Amodiaquine / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000201:enzymology; D008297:Male; D011700:Putrescine / Q000378:metabolism; D011796:Quinacrine / Q000494:pharmacology; D051381:Rats
chemical_list: D000962:Antimalarials; D000655:Amodiaquine; D002738:Chloroquine; D006631:Amine Oxidase (Copper-Containing); D011796:Quinacrine; D011700:Putrescine