[Changes in the female gonads of the chick embryo after tamoxifen].
Tamoxifen has been given to Chick embryos between the 3rd and 7th day at doses of 0.2-2 mg/egg. It was non-toxic and strongly anti-estrogenic. The female gonads were modified in their development. The ovary showed dense medulla with numerous cords and a reduced cortex. The right gonad partially regressed and was "masculinized". Mullerian ducts normally regressed in tamoxifen-treated male embryos. These results suggest the physiological intervention of estrogen during the normal embryonic female development.
D000818:Animals; D002642:Chick Embryo; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D010053:Ovary / Q000187:drug effects* / Q000196:embryology / Q000473:pathology; D013629:Tamoxifen / Q000494:pharmacology*
D013629:Tamoxifen; D004958:Estradiol
Modifications des gonades femelles de l'embryon de poulet, après action du tamoxifène.