Influence of dianhydrogalactitol on some platelet functions in vitro.
Platelet-rich plasma was incubated with dianhydrogalactitol (DAG) in vitro. This moderately diminished platelet aggregation induced by adrenaline and to a smaller degree by adenosine diphosphate /ADP) or collagen. The availability of platelet factor 3 induced by ADP, adrenaline or collagen was decreased irrespective of the inducer. The release of platelet factor 4 was unaffected. Reptilase clot retraction induced by ADP or collagen was slightly inhibited. Uptake of 14C-serotonin was slightly decreased. Uptake of 14C-adenine was normal. Platelet adhesion onto glass was not depressed. DAG did not release lactic dehydrogenase from the cytoplasm of the platelets. Coagulation factors were not affected.
D001792:Blood Platelets / Q000187:drug effects* / Q000502:physiology; D003961:Dianhydrogalactitol / Q000494:pharmacology*; D006801:Humans; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D010977:Platelet Factor 3 / Q000378:metabolism; D010978:Platelet Factor 4 / Q000378:metabolism; D013402:Sugar Alcohols / Q000494:pharmacology*; D013918:Thrombin Time
D013402:Sugar Alcohols; D010977:Platelet Factor 3; D010978:Platelet Factor 4; D003961:Dianhydrogalactitol