New light on the mechanism of action of disodium cromoglycate.
Disodium cromoglycate (DSCG) shows a prolonged protective effect against histamine on the smooth muscle of guinea pig ileum. Preventing allergen-induced mediator release from mast cells as well as protection of smooth muscle against mediators already released can both explain a beneficial effect of DSCG in the treatment of bronchial asthma and food allergy. It is believed that disappointing clinical trials with many new anti-allergic drugs, e.g. RS 7540, can be explained by the lack of protective effect on the smooth muscle of target organs.
D000818:Animals; D004205:Cromolyn Sodium / Q000494:pharmacology*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006633:Histamine Antagonists; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*
D006633:Histamine Antagonists; D006632:Histamine; D004205:Cromolyn Sodium