title: In vitro activity of 2-alkyl-3-hydroxy-1,4-naphthoquinones against Theileria parva.
abstract: A variety of naphthoquinones have veen prepared and evaluated in vitro against the causative agent of the cattle disease East Coast Fever-Theileria parva infection. It is concluded from structure-activity studies that a 2-hydroxyl moiety es essential for high activity. The most active compounds tested were 2-hydroxy-3-alkyl-1,4-naphthoquinones in which the alkyl moiety was cyclohexyl, cyclohexylcyclohexyl, tridecyl, or tetradecyl.
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D016782:Apicomplexa / Q000187:drug effects*; D002417:Cattle; D009285:Naphthoquinones / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship; D013801:Theileriasis / Q000469:parasitology*
chemical_list: D000981:Antiprotozoal Agents; D009285:Naphthoquinones