[Effect of diuretics on electrolyte and non-electrolyte penetration of intercellular spaces].
The effect of novurit, mannitol and furosemide on permeability of the intercellular interstice of the frog urinary bladder by inulin, saccharose, iodide, lithium cation and fluorescein moving against a concentration gradient was examined. Novurit (0.5--6 mM/l) raised permeability of the intercellular interstice by all test substances and ions. Mannitol (210 mM/l) increased permeability of the intercellular interstice by lithium cation and fluorescein, while furosemide failed to exert any effect on permeability. The character of asymmetrical ionic flows moving in opposite directions across the wall of the frog urinary bladder is discussed.
D000479:Alkylmercury Compounds / Q000494:pharmacology; D000818:Animals; D004232:Diuretics / Q000494:pharmacology*; D004338:Drug Combinations / Q000494:pharmacology; D005110:Extracellular Space / Q000378:metabolism*; D005665:Furosemide / Q000494:pharmacology; D007684:Kidney Tubules / Q000187:drug effects*; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D008954:Models, Biological; D009941:Organomercury Compounds / Q000494:pharmacology; D010539:Permeability; D011896:Rana temporaria; D013806:Theophylline / Q000494:pharmacology; D001743:Urinary Bladder / Q000187:drug effects* / Q000378:metabolism
D000479:Alkylmercury Compounds; D004232:Diuretics; D004338:Drug Combinations; D009941:Organomercury Compounds; C021054:mercurophylline; D008353:Mannitol; D005665:Furosemide; D013806:Theophylline
Vliianie diuretikov na pronitsaemost' mezhkletochnykh promezhutkov dlia neélektrolitov i élektrolitov.