title: The effects of molybate, tungstate and lxd on aldehyde oxidase and xanthine dehydrogenase in Drosophila melanogaster.
abstract: The effects of dietary sodium molybdate and sodium tungstate on eye color and aldehyde oxidase and xanthine dehydrogenase activities have been determined in Drosophila melanogaster. Dietary sodium tungstate administration has been used as a screening procedure to identify two new lxd alleles. Tungstate administration results in increased frequencies of "brown-eyed" flies in lxd stocks and a coordinate decrease in AO and XDH activities in all genotypes tested. The two new lxd alleles affect AO and XDH in a qualitatively but not quantitatively similar fashion to the original lxd allele. AO and XDH activity and AO-CRM levels appear much more sensitive to mutational perturbations of this gene-enzyme than do XDH-CRM levels in the genotypes tested.
mesh_terms: D000444:Aldehyde Dehydrogenase; D000445:Aldehyde Oxidoreductases / Q000235:genetics*; D000483:Alleles; D000818:Animals; D003433:Crosses, Genetic; D004331:Drosophila melanogaster / Q000201:enzymology* / Q000235:genetics; D005260:Female; D005838:Genotype; D007658:Ketone Oxidoreductases / Q000235:genetics*; D008297:Male; D008982:Molybdenum / Q000494:pharmacology*; D009154:Mutation; D014414:Tungsten / Q000494:pharmacology*; D014968:Xanthine Dehydrogenase / Q000235:genetics*
chemical_list: D008982:Molybdenum; D014968:Xanthine Dehydrogenase; D000445:Aldehyde Oxidoreductases; D007658:Ketone Oxidoreductases; D000444:Aldehyde Dehydrogenase; D014414:Tungsten