Inhibition of CFUE and BFUE by mononuclear peripheral blood cells during chronic benzene treatment in rabbits.
Peripheral blood cells from untransfused rabbits that were treated with a moderate dose of benzene during 2 months were cocultivated with autologous and normal bone marrow. In a significant number of experiments, CFUE and BFUE growth of both autologous and normal bone marrow was suppressed. Further experiments showed that this inhibition was associated with adherent mononuclear peripheral blood cells. It is concluded that benzene, an established myelotoxic agent, also induces CFUE and BFUE inhibiting activity in adherent peripheral blood cells.
D000818:Animals; D001554:Benzene / Q000494:pharmacology*; D001773:Blood Cells / Q000187:drug effects*; D001853:Bone Marrow / Q000187:drug effects*; D002417:Cattle; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D011817:Rabbits
D001554:Benzene