[Effect of chemical defoaming agents on the mass exchange rate in the oxytetracycline biosynthesis process].
The effect of chemical foam suppressors of various classes on the intensity of Streptomyces rimosus respiration, concentrations of dissolved oxygen and carbon dioxide and gas levels in the fermentation broth of oxytetracycline was studied. Its was shown that addition of the foam suppressors, as a rule, resulted in a decreased rate of the oxygen mass transfer due to the decreased surface of the phase contact gas-liquid. This decrease was not so significant as that in case of uninhibited intensity of the fermentation broth foaming. A different character of the effect of different foam suppressors on the biosynthetic process was noted. The effect of the foam suppressors was decreased by their regular addition in low amounts.
D000934:Antifoaming Agents / Q000494:pharmacology*; D002245:Carbon Dioxide / Q000378:metabolism; D003470:Culture Media / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D010100:Oxygen / Q000378:metabolism; D010118:Oxytetracycline / Q000096:biosynthesis*; D013302:Streptomyces / Q000187:drug effects / Q000378:metabolism; D013501:Surface-Active Agents / Q000494:pharmacology*; D013997:Time Factors
D000934:Antifoaming Agents; D003470:Culture Media; D013501:Surface-Active Agents; D002245:Carbon Dioxide; D010100:Oxygen; D010118:Oxytetracycline
Vliianie khimicheskikh penogasitelei na skorost' massobmena v protsesse biosinteza oksitetratsiklina.