Baculovirus induction of a DNA polymerase.
The baculovirus, Autographa california nuclear polyhedrosis virus, induced a new aphidicolin-sensitive, alpha-like, DNA polymerase upon infection of the lepidopteran noctuid, Trichoplusia ni. The new virus-induced DNA polymerase could be separated from the host alpha-like polymerase by phosphocellulose chromatography. The two polymerases differed in their sensitivities to heat inactivation, high salt concentrations, and 0.1 M phosphate buffer.
D000818:Animals; D016590:Aphidicolin; D002021:Buffers; D004259:DNA-Directed DNA Polymerase / Q000096:biosynthesis* / Q000378:metabolism; D004224:Diterpenes / Q000494:pharmacology; D004790:Enzyme Induction; D006358:Hot Temperature; D007304:Insect Viruses / Q000201:enzymology*; D007915:Lepidoptera / Q000382:microbiology; D019384:Nucleic Acid Synthesis Inhibitors
D002021:Buffers; D004224:Diterpenes; D019384:Nucleic Acid Synthesis Inhibitors; D016590:Aphidicolin; D004259:DNA-Directed DNA Polymerase