"On-off" syndrome treated with lithium carbonate: a case report.
The authors describe a 42-year-old man who developed "on-off" episodes and for whom lithium carbonate proved an effective treatment. They speculate that the predominant effect of lithium in the "on-off" syndrome is to prevent L-dopa desensitization of the dopamine receptor.
D000328:Adult; D001264:Athetosis / Q000139:chemically induced / Q000188:drug therapy*; D002819:Chorea / Q000139:chemically induced / Q000188:drug therapy*; D006801:Humans; D007980:Levodopa / Q000009:adverse effects; D008094:Lithium / Q000097:blood / Q000627:therapeutic use*; D016651:Lithium Carbonate; D008297:Male; D010300:Parkinson Disease / Q000188:drug therapy*; D011954:Receptors, Dopamine / Q000187:drug effects
D011954:Receptors, Dopamine; D016651:Lithium Carbonate; D007980:Levodopa; D008094:Lithium