Interaction of organic dyes with hepatic microsomal drug-metabolizing monoöxygenases in vitro.
Organic dyes such as malachite green, methylene blue, fuchsin, safranine T, neutral red, phenazine methosulphate, riboflavin, dichlorophenolindophenol, phenolphthalein, and fluorescein, inhibit hepatic microsomal mixed-function oxidases and, partly, enhance, partly, inhibit hepatic microsomal NADPH-dependent cytochrome c and neotetrazolium reductases, in contrast to other inhibitors of drug metabolism which do not affect cytochrome c reductase but only interact with cytochrome P-450.
D000818:Animals; D004396:Coloring Agents / Q000494:pharmacology*; D003579:Cytochrome Reductases / Q000037:antagonists & inhibitors*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors; D009245:NADH Dehydrogenase / Q000037:antagonists & inhibitors*; D009251:NADPH-Ferrihemoprotein Reductase / Q000037:antagonists & inhibitors*; D010089:Oxidoreductases, N-Demethylating / Q000037:antagonists & inhibitors; D010090:Oxidoreductases, O-Demethylating / Q000037:antagonists & inhibitors; D051381:Rats
D004396:Coloring Agents; D006899:Mixed Function Oxygenases; D010090:Oxidoreductases, O-Demethylating; D010089:Oxidoreductases, N-Demethylating; D003579:Cytochrome Reductases; C021848:NADPH-tetrazolium reductase; D009251:NADPH-Ferrihemoprotein Reductase; D009245:NADH Dehydrogenase