[There is no relationship between endogenous insulin release, release during OGTT and androgenic function in patients suffering from psychogenic impotence (author's transl)].
We have studied androgenic function (basal testosterone, DHT, E2, androsterone, etiocholanolone, and dynamic response to TRH (hPr) and LRH (LH, FSH) and insulin induced release during O.G.T.T. in 35 patients suffering from "psychogenic impotence" and glucose intolerance. We found no correlation between androgenic parameters and insulin release thus affirming the hypothesis of an antagonism between the two systems as postulated previously by others. However we found a positive significant correlation between basal prolactin level and the testosterone/dihydrotestosterone ratio together with a slight increase of basal prolactin and E2 and a decrease of DHT in the patients group compared to non impotent non glucose intolerant group. Our results suggest that a moderate hyperprolactinemia, whose origin is discussed, could participate in the pathogenesis of sexual disturbances in some patients with glucose tolerance.
D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase / Q000502:physiology; D000328:Adult; D000738:Androsterone / Q000097:blood; D007172:Erectile Dysfunction / Q000503:physiopathology*; D005043:Etiocholanolone / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood; D005947:Glucose / Q000502:physiology; D005951:Glucose Tolerance Test; D006801:Humans; D007328:Insulin / Q000502:physiology*; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000097:blood; D013739:Testosterone / Q000097:blood
D007328:Insulin; D013739:Testosterone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D005043:Etiocholanolone; D000738:Androsterone; D013741:3-Oxo-5-alpha-Steroid 4-Dehydrogenase; D005947:Glucose
Il n'existe pas de relation entre la libération insulinique lors de l'HGPO et différents paramètres androgéniques chez des patients souffrant d'impuissance sexuelle érective.