[Copper II complexes of N-heterocyclic formylisothiosemicarbazones with antimicrobial and beta-lactamase inhibitory activity].
The synthesis of copper(III)-complexes from quinoline-2- or quinoxaline-2-aldehyde-isothiosemicarbazones in pyridine and the elucidation of their structure are described. Some of the new substances exhibit an inhibitory action on growth of gram-positive bacteria, especially Bacillus subtilis (ATCC 6633), furthermore in vitro the beta-lactamase I action is inhibited. Using penicillin-resistant Staphylococci as test strains a strong penicillin-synergistic action was discovered.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis; D001412:Bacillus subtilis / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003300:Copper; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D011804:Quinolines; D011810:Quinoxalines; D013211:Staphylococcus aureus / Q000201:enzymology; D013882:Thiosemicarbazones; D065093:beta-Lactamase Inhibitors
D000900:Anti-Bacterial Agents; D009942:Organometallic Compounds; D011804:Quinolines; D011810:Quinoxalines; D013882:Thiosemicarbazones; D065093:beta-Lactamase Inhibitors; D003300:Copper
Kupfer-II-komplexe N-heterocyclischer Formylisothiosemicarbazone mit antimikrobieller und beta-Lactamasen inhibierender Wirkung.