Evidence for an H-2-linked Ir gene regulating the immune response to a TI-2 antigen, DNP-Ficoll.
Various H-2 congenic mouse pairs were immunized with 10 microgram of DNP53-Ficoll, a thymic independent (TI-2) antigen. Four-day primary splenic immune responses were measured by a DNP-reactive PFC assay. Significantly different responses were noted between partners of many congenic pairs. An H-2 linked Ir gene for DNP-Ficoll appears likely.
D000818:Animals; D000941:Antigens; D004136:Dinitrobenzenes / Q000276:immunology; D005362:Ficoll / Q000276:immunology; D005796:Genes; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics*; D006462:Hemolytic Plaque Technique; D051379:Mice; D008809:Mice, Inbred C3H / Q000276:immunology; D008810:Mice, Inbred C57BL / Q000276:immunology; D013154:Spleen / Q000276:immunology
D000941:Antigens; D004136:Dinitrobenzenes; D006183:H-2 Antigens; D005362:Ficoll