title: [Increase in DNAase activity in rat urine after intraperitoneal administration of DNAases].
abstract: After intraperitoneal administration of DNAase into rats maximal increase in the enzymatic activity was observed in urine within 3-4 hrs. This suggests the ability of DNAase to penetrate through cell barriers without a loss of its biological activity. The importance of the phenomenon is discussed considering possible use of DNAases as protector of the body against heterologous nucleic acids.
mesh_terms: D000818:Animals; D001692:Biological Transport; D003851:Deoxyribonucleases / Q000008:administration & dosage / Q000652:urine*; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D007274:Injections, Intraperitoneal; D007700:Kinetics; D008297:Male; D051381:Rats
chemical_list: D003851:Deoxyribonucleases
vernacular_title: Povyshenie DNK-aznoi aktivnosti mochi krys posle vnutribriushinnogo vvedeniia DNK-az.