title: Glycolysis in rat neostriatal slices following kainic acid injections.
abstract: In in vitro incubations, kainic acid-lesioned neostriatal slices from rat brain showed decreases in oxygen consumption (50%) and in the conversion of both [1-14C]glucose (43%) and [6-14C]glucose (69%) to 14CO2 as compared to controls. The elevation in the C1/C6 14CO2 ratio suggested the pentose phosphate pathway was less affected than the Embden-Meyerhof path in kainic acid-injected gliotic tissue. Increasing the potassium concentration from 6 to 50 mM caused increases in oxygen consumption and glucose utilization in both control and kainic acid-lesioned neostriatal slices; this is consistent with, but not conclusive of, a potassium-stimulating effect on glial as well as neuronal metabolism.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002245:Carbon Dioxide / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects*; D006019:Glycolysis / Q000187:drug effects*; D007608:Kainic Acid / Q000633:toxicity*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects; D011759:Pyrrolidines / Q000633:toxicity*; D051381:Rats
chemical_list: D011759:Pyrrolidines; D002245:Carbon Dioxide; D007608:Kainic Acid