Pharmacokinetics of mitomycin C in rabbit and human.
A sensitive and specific high-pressure liquid chromatographic assay was developed to characterize the plasma elimination and urinary excretion of mitomycin C in humans. Extraction of mitomycin C and an internal standard, porfiromycin, from plasma by chromatography over a non-ionic resin, Porapak Q, yields high recovery of both compounds and facilitates measurement of as little as 5 ng mitomycin C by reversed-phase high-pressure liquid chromatography. The assay was used to characterize the plasma elimination of mitomycin C in rabbits and was shown to be applicable to the characterization of the pharmacokinetics of mitomycin C in humans receiving as little as 8 mg/m2.
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007700:Kinetics; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage / Q000378:metabolism*; D011817:Rabbits; D013045:Species Specificity
D008937:Mitomycins; D016685:Mitomycin