title: Effects of ethyl ester derivatives of valproic acid metabolites on pentylenetetrazol seizures in mice.
abstract: The anticonvulsant activity of the ethyl esters of the major valproic acid metabolites was assessed against minimal pentylenetetrazol seizures in adult male ICR mice. The ethyl ester 3-hydroxy-propylpentanoic acid was found to possess significant anticonvulsant activity.
mesh_terms: D000818:Animals; D004334:Drug Administration Schedule; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D014635:Valproic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: C032264:valproic acid ethyl ester; D014635:Valproic Acid; C032265:3-ketovalproic acid ethyl ester; C032266:3-hydroxypropylpentanoic acid ethyl ester; D010433:Pentylenetetrazole