DNA damage induced with near-ultraviolet light irradiation in the presence of quinoxaline-1,4-dioxide.
When Bacillus subtilis transforming DNA was irradiated with near-ultraviolet light in the presence of quinoxaline-1,4-dioxide, the activity of DNA decreased rapidly. This loss of activity was ascribed to damages on DNA that lead to chain cleavages of the molecule. A feature of this phototoxic action of the reagent is that it takes place in nitrogen atmosphere and is inhibited by oxygen.
D001412:Bacillus subtilis / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D004269:DNA, Bacterial / Q000528:radiation effects*; D009153:Mutagens / Q000494:pharmacology*; D011810:Quinoxalines / Q000494:pharmacology*; D014466:Ultraviolet Rays
D004269:DNA, Bacterial; D009153:Mutagens; D011810:Quinoxalines; C003282:quindoxin