title: [Structural and numerical chromosome abnormalities in human malignant melanoma cell lines (author's transl)].
abstract: Characteristics and cytogenetic markers of 36 human malignant cell lines were studied. Structural abnormalities of chromosomes 1, 2, 3, 6, 7, 9, 11, 12 and 22 were the most frequent. Relative polysomy for chromosome 3, 7, 16, 19, 20, 22 and monosomy for chromosome 9 were observed. Each cell line contained structural and/or numerical abnormalities of chromosome 7, but structural abnormalities of this chromosome were only observed in cell lines derived from metastases; while only polysomy of chromosome 7 was observed in cell lines derived from primaries or local recurrences.
mesh_terms: D002460:Cell Line; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D025063:Chromosome Disorders; D006801:Humans; D008545:Melanoma / Q000235:genetics*; D009362:Neoplasm Metastasis; D014178:Translocation, Genetic
vernacular_title: Anomalies chromosomiques numériques et structurales dans 36 lignées de mélanome malin humain.