[Effect of 5-fluorouracil, ftorafur, and imidazole carboxamide on the kinetics of the primary immune response in mice].
Experiments on CBA and CBA x C57BI mice were carried out to study the effect of 5-ftoruracil, ftorafur and imidazolcarboxamide on the kinetics of the primary immune response. The drugs were administered in a single dose 48 or 72 hours after immunization of the animals with sheep red blood cells. The number of antibody-forming cells was determined every 4 hours after the injection of a cytostatic. It was shown that the kinetics of the formation of antibody producers assumes a wave-like pattern under the effect of the drugs studied. It was also demonstrated that the kinetics of immunogenesis inhibition is determined by the mechanism of the molecular cytostatic action of the drugs.
D000620:Aminoimidazole Carboxamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D003864:Depression, Chemical; D005472:Fluorouracil / Q000031:analogs & derivatives* / Q000494:pharmacology*; D006824:Hybridization, Genetic; D007093:Imidazoles / Q000494:pharmacology*; D007166:Immunosuppressive Agents; D007700:Kinetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D005641:Tegafur / Q000494:pharmacology*
D007093:Imidazoles; D007166:Immunosuppressive Agents; D005641:Tegafur; D000620:Aminoimidazole Carboxamide; C031340:imidazolecarboxamide; D005472:Fluorouracil
Vliianie 5-ftoruratsila, ftorafura i imidazolkarboksamida na kinetiku pervichnogo immunogo otveta u mysheĭ.