title: [Treatment of postoperative pain with non-narcotic drugs; evaluation of lysine acetylsalicylate in high doses. Double-blind controlled study].
abstract: Further work on the treatment of postoperative pain with non-narcotic analgesics involving an investigation of the effect of twice the customary dose of lysine acetylsalicylate in a double-blind trial versus meperidine is reported. In addition to subjective and objective pain, the parameters included blood pressure, pulse rate, breathing rate, sweating, pupil diameter, nausea, vomiting, somnolence, hiccuping feeling of cold, erythema, dizziness, and nasograstric sound intolerance. Application of Wilcoxon's non-parametric tests and the chi-square test showed that the drug was as good as or better than meperidine with regard to pain, and performed very well overall with respect to the other parameters. The conclusion is drawn that its administration in high doses is justified in many patients subjected to general surgery.
mesh_terms: D000005:Abdomen / Q000601:surgery; D001241:Aspirin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008239:Lysine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008614:Meperidine / Q000008:administration & dosage / Q000627:therapeutic use*; D010149:Postoperative Pain / Q000188:drug therapy*
chemical_list: D008614:Meperidine; D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate
vernacular_title: Trattamento del dolore post-operatorio con farmaci non narcotici: valutazione dell'acetilsalicilato di lisina ad alto dosaggio. Studio controllato a doppio cieco.