[Influence of centrophenoxine on the incorporation of 32P into glycerophosphatides of neurons and gliocytes (author's transl)].
Investigations on the incorporation of intraventricularly injected 32P in neuronal and glial phosphatidylinositol, phosphatidylserine, phosphatidylcholine, phosphatidylethanolamine and ethanolamine plasmalogen at intervals ranging from 5 to 60 min showed different incorporation rates of the radioactive precursor into neuronal and glial phosphatides. The incorporation rate of 32P into the different glycerophosphatides was faster in neurons as compared to the gliocyte compartment. Phosphatidylinositol showed the fastest and ethanolamine plasmalogen the slowest incorporation of 32P in both neurons and gliocytes. Centrophenoxine (meclofenoxate, Helfergin) increased the incorporation of 32P into phosphatidylserine and ethanolamine plasmalogen of both glial and neuronal cell bodies whereas the incorporation of the radioactive precursor into phosphatidylcholine was slightly inhibited. The incorporation rate into phosphatidylinositol and phosphatidylethanolamine was not influenced by centrophenoxine. The data obtained in the present work suggest that centrophenoxine may stimulate excitatory neurons and may be involved in the process of synaptic transmission and axonal conduction.
D000818:Animals; D005260:Female; D006016:Glycolates / Q000494:pharmacology*; D008297:Male; D002504:Meclofenoxate / Q000494:pharmacology*; D009457:Neuroglia / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects*; D010712:Phosphatidic Acids / Q000096:biosynthesis*; D010713:Phosphatidylcholines / Q000096:biosynthesis; D010714:Phosphatidylethanolamines / Q000096:biosynthesis; D010716:Phosphatidylinositols / Q000096:biosynthesis; D010718:Phosphatidylserines / Q000096:biosynthesis; D010761:Phosphorus Radioisotopes / Q000378:metabolism; D010955:Plasmalogens / Q000096:biosynthesis; D051381:Rats
D006016:Glycolates; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010716:Phosphatidylinositols; D010718:Phosphatidylserines; D010761:Phosphorus Radioisotopes; D010955:Plasmalogens; D002504:Meclofenoxate
Zum Einfluss von Centrophenoxin auf den Einbau von 32P in Glycerinphosphatide der Neuronen und Gliazellen.