title: Successive factor VIII doses for a haemophiliac undergoing major surgery calculated on a micro-computer.
abstract: Doses of factor VIII to be infused into a haemophiliac undergoing major surgery were calculated on a micro-computer. The degree to which the particular patient responded to infused factor VIII and the rate at which it decayed were estimated by two pre-operative experiments. Plasma levels of factor VIII were predicted over fourteen days during which time the patient was infused with 53,000 iu. A continuous plot of predicted values with time was displayed on a video monitor. The predicted values showed good agreement with assay results.
mesh_terms: D000328:Adult; D001780:Blood Coagulation Tests; D003201:Computers; D004305:Dose-Response Relationship, Drug; D005169:Factor VIII / Q000008:administration & dosage*; D005269:Femur / Q000601:surgery; D006207:Half-Life; D006406:Hematoma / Q000601:surgery; D006467:Hemophilia A / Q000188:drug therapy*; D006622:Hip Prosthesis; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008838:Microcomputers; D009055:Mouth / Q000601:surgery; D010027:Osteotomy; D011183:Postoperative Complications / Q000188:drug therapy; D013997:Time Factors
chemical_list: D005169:Factor VIII