title: Pyochelin: novel structure of an iron-chelating growth promoter for Pseudomonas aeruginosa.
abstract: Pyochelin, an endogenous growth promoter that solubilizes ferric iron, has been isolated from Pseudomonas aeruginosa, including clinical strains. The structure of pyochelin has been assigned as 2-(2-o-hydroxyphenyl-2-thiazolin-4-yl)-3-methylthiazolidine-4-carboxylic acid and is of a different type from those previously assigned to siderophores (siderochromes) from bacteria. The assignment rests on 1H and 13C NMR data, high-resolution (including field desorption) mass spectrometry, and spectroscopic properties of synthetic model compounds. Pyochelin is presumed to be biosynthesized from salicylic acid and two moles of cysteine.
mesh_terms: D006133:Growth Substances; D007502:Iron Chelating Agents / Q000096:biosynthesis; D009682:Magnetic Resonance Spectroscopy; D010636:Phenols / Q000096:biosynthesis; D011550:Pseudomonas aeruginosa / Q000032:analysis; D013844:Thiazoles
chemical_list: D006133:Growth Substances; D007502:Iron Chelating Agents; D010636:Phenols; D013844:Thiazoles; C025316:pyochelin