Potential risk of prolonged administration of stimulant medication for hyperactive children.
A battery of clinical laboratory evaluations was obtained biannually in hyperactive boys treated continuously with methylphenidate hydrochloride for 1 to 4 years. Blood pressure and heart rate were evaluated annually. Pretreatment baseline studies did not implicate low blood glucose or calcium levels, or anemia, as factors contributing to hyperactivity. Prolonged administration of methylphenidate hydrochloride was not associated with disturbances in the hemopoietic, endocrine, hepatic or cardiovascular functions analyzed.
D001289:Attention Deficit Disorder with Hyperactivity / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D002648:Child; D004802:Eosinophilia / Q000150:complications; D006400:Hematocrit; D006801:Humans; D008134:Long-Term Care; D008137:Longitudinal Studies; D008297:Male; D008774:Methylphenidate / Q000009:adverse effects* / Q000627:therapeutic use; D010088:Oxidoreductases / Q000032:analysis; D012306:Risk; D000637:Transaminases / Q000032:analysis
D008774:Methylphenidate; D010088:Oxidoreductases; D000637:Transaminases