Oligoelements in dog's chronic hepatitis and liver cirrhosis through dimethylnitrosamine.
By the emission spectrographic analysis, we have searched the following oligoelements: Mn, Cd, Cu, Be, Cr, Ge, Nb, Ga, Zr, W, Pb, Sn, As, Zn, Ag, Sb, Ni, Bi, Co, Mo, and V, in the aortic arterial blood, in the caval, portal and suprahepatic vein blood, in ascite and in the bile, in control and in intoxicated dogs with dimethylnitrosamine (DMNA). Be, Ge, Nb, Ga, W, As, Sb were never found. Increased values of Cu, Mn, Pb, Zn, Ni, Co, Mo and V were noticed. The differences between the values obtained at intoxicated dogs against the control dogs were sometimes clear; at other times they were equal. This is the case of Ag in the aortic and suprahepatic vein blood and in the bile. In the portal vein blood Zn exceeds almost two times the values obtained in the intoxicated dogs. Also in the portal vein blood, Mo is almost three times more in the control dogs than in the intoxicated ones. But, generally, the values of the controls are below those found by the intoxicated dogs.
D000818:Animals; D001646:Bile / Q000032:analysis; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D002908:Chronic Disease; D004128:Dimethylnitrosamine; D004195:Disease Models, Animal; D004285:Dogs; D006505:Hepatitis / Q000503:physiopathology*; D008099:Liver / Q000032:analysis*; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000503:physiopathology*; D008670:Metals / Q000032:analysis* / Q000097:blood
D008670:Metals; D004128:Dimethylnitrosamine