[Cytogenetic analysis of thioTEPA-induced translocations in the spermatids of male mice].
Spermatocytes of 36 reciprocal translocation heterozygotes at diakinesis-MI stage were studied cytogenetically. There were 38.8 % cells with rings and 32.8 % - with chains and univalents among 3666 cells. It is concluded that intensive mutational process producing 30 % of translocation heterozygotes is characterized by random breakage along the chromosomes.
D000818:Animals; D003433:Crosses, Genetic; D006579:Heterozygote; D007248:Infertility, Male / Q000235:genetics; D008297:Male; D008540:Meiosis / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D013087:Spermatids / Q000187:drug effects* / Q000648:ultrastructure; D013094:Spermatozoa / Q000187:drug effects*; D013852:Thiotepa / Q000494:pharmacology*; D014178:Translocation, Genetic / Q000187:drug effects*
D013852:Thiotepa
Tsitogeneticheskiĭ analiz translokatsiĭ, indutsirovannykh tioTEF v spermatidakh samtsov mysheĭ.