Cyclic neutropenia. A tale of two brothers and their family.
A family history encompassing four generations is presented. Definite cyclic neutropenia has been noted in two generations. In one member, the symptoms abated as she grew older. One 12-year-old member died of clostridial septicemia secondary to gangrene of the terminal ileum. At autopsy he was found to have amyloidosis. A trial of lithium carbonate therapy was carried out in a 7-year-old male but a positive hematologic response was not obtained.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000380:Agranulocytosis / Q000235:genetics*; D000686:Amyloidosis / Q000150:complications / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008094:Lithium / Q000627:therapeutic use; D016651:Lithium Carbonate; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D010375:Pedigree; D010507:Periodicity; D013577:Syndrome
D016651:Lithium Carbonate; D008094:Lithium