Alterations in cerebrospinal fluid dopamine metabolites following physostigmine infusion.
The effect of IV physostigmine administration on the cerebrospinal fluid (CSF) levels of homovanillic acid (HVA) and dihydroxyphenylacetic acid (DOPAC) in normal subjects was determined. After an adjustment for differing CSF concentrations of probenecid, physostigmine was found to elevate CSF HVA and DOPAC concentrations. The authors discuss these changes in CSF HVA and DOPAC and their possible relationship to the ability of physostigmine to decrease the symptoms of some patients with tardive dyskinesia.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000134:cerebrospinal fluid; D000328:Adult; D004298:Dopamine / Q000134:cerebrospinal fluid*; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D008297:Male; D008875:Middle Aged; D010830:Physostigmine / Q000494:pharmacology*; D011339:Probenecid / Q000134:cerebrospinal fluid
D015102:3,4-Dihydroxyphenylacetic Acid; D010830:Physostigmine; D011339:Probenecid; D004298:Dopamine; D006719:Homovanillic Acid