Role of fetal insulin in glycogen metabolism in the liver of the rat fetus.
In the near-term rat fetus liver, insulin decreased phosphorylase a activity, slightly increased synthase a activity and increased both glycogen content and 14C-glucose incorporation into glycogen; anti-insulin serum increased phosphorylase a activity and decreased glucose incorporation but did not modify synthase a activity. When pregnant rats were previously rendered hypoglycemia, insulin injection to the fetus enhanced glycogen accumulation. It is concluded that insulin is a regulatory factor of secondary importance for liver glycogen storage through its action on phosphorylase activity.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006006:Glycogen Synthase / Q000378:metabolism; D007328:Insulin / Q000494:pharmacology / Q000502:physiology*; D007330:Insulin Antibodies; D008099:Liver / Q000187:drug effects / Q000196:embryology* / Q000201:enzymology; D008112:Liver Glycogen / Q000096:biosynthesis*; D006005:Phosphorylases / Q000378:metabolism; D011247:Pregnancy; D051381:Rats
D001786:Blood Glucose; D007328:Insulin; D007330:Insulin Antibodies; D008112:Liver Glycogen; D006005:Phosphorylases; D006006:Glycogen Synthase; D005947:Glucose