Histochemical assessment of 3 beta-hydroxysteroid dehydrogenase activity in the testes of rats following acute administration of aflatoxin B1.
Aflatoxin B1 (150 microgram) was administered i.p. to adult male rats on 3 occasions at intervals of 48 h. The testicular distribution and localisation of 3 beta-hydroxysteroid dehydrogenase (3 beta-HSD) was evaluated histochemically in rats killed 24 h after the last dose of aflatoxin, with or without human chorionic gonadotropin (HCG) stimulation. Diminished augmentation of seminal vesicle and prostate weights to HCG stimulation was recorded in male rats pretreated with aflatoxin. There were no convincing effects of aflatoxin pretreatment on the histochemical localisation and distribution of 3 beta-HSD in the testes of the rats used in this investigation.
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism*; D016604:Aflatoxin B1; D000348:Aflatoxins / Q000633:toxicity*; D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D006651:Histocytochemistry; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011467:Prostate / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012669:Seminal Vesicles / Q000187:drug effects; D013737:Testis / Q000187:drug effects / Q000201:enzymology*
D000348:Aflatoxins; D006063:Chorionic Gonadotropin; D016604:Aflatoxin B1; D015096:3-Hydroxysteroid Dehydrogenases