Delayed hemolytic transfusion reaction caused by a primary immune response.
Delayed hemolytic transfusion reactions usually occur as a result of a secondary immune response with maximal hemolysis occurring seven days posttransfusion. We report a delayed hemolytic transfusion reaction in which hemoglobinuria, anemia, and reticulocytosis developed four weeks after transfusion. The incriminated antibody, anti-C, was first detected eight weeks posttransfusion using enzyme-treated red blood cells. We conclude, that in all likelihood, this hemolytic transfusion reaction was due to a primary immune response, this case illustrates the importance of sequential testing in cases of suspected transfusion reactions.
D000328:Adult; D000743:Anemia, Hemolytic / Q000209:etiology* / Q000276:immunology; D000915:Antibody Affinity; D000917:Antibody Formation; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007983:Lewis Blood Group Antigens / Q000276:immunology; D008297:Male; D012204:Rh-Hr Blood-Group System / Q000276:immunology; D013997:Time Factors; D065227:Transfusion Reaction
D007983:Lewis Blood Group Antigens; D012204:Rh-Hr Blood-Group System