title: Central respiratory stimulant effect by thyrotropin in releasing hormone in the rat.
abstract: Anaesthetized male rats were injected intracerebroventricularly with the tripeptide, thyrotropin releasing hormone (TRH). Respiratory frequency (f), tidal volume (VT) and minute volume (VE) were measured in a closed whole body plethysmograph by a low pressure transducer connected to a Grass polygraph. TRH induced an approximately 50% increase in f, while VT was not altered. VE increased in the same proportion as f. Our results indicate that TRH neurons or TRH-sensitive receptors may be involved in the regulation of central respiratory activity.
mesh_terms: D000818:Animals; D002552:Cerebral Ventricles; D004305:Dose-Response Relationship, Drug; D007267:Injections; D008297:Male; D010993:Plethysmography, Whole Body; D051381:Rats; D011919:Rats, Inbred Strains; D012119:Respiration / Q000187:drug effects*; D013972:Thyrotropin / Q000494:pharmacology*; D013973:Thyrotropin-Releasing Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D013990:Tidal Volume
chemical_list: D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin