title: Studies on kidney function in subjects exposed to organic solvents. IV. Effect on 51-Cr-EDTA clearance.
abstract: Glomerular filtration rate (GFR) was studied by measuring the 51-Cr-EDTA clearance with single bolus injection technique in 107 men exposed to styrene, toluene or toluene and xylene in their professions and in 48 non-exposed male controls. The clearance values of the controls were significantly related both to body surface area (BSA) and age. These relations were used to calculate expected clearances for the exposed subjects. The clearances of the exposed subjects were on an average 3.8% higher than expected, according to BSA and age in this group. This divergence was not significant. Thus, no reduction in GFR was found in the subjects exposed to organic solvents.
mesh_terms: D000328:Adult; D000367:Age Factors; D001830:Body Surface Area; D002857:Chromium; D004492:Edetic Acid; D004781:Environmental Exposure; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012997:Solvents / Q000506:poisoning*; D013343:Styrenes / Q000506:poisoning; D014050:Toluene / Q000506:poisoning; D014992:Xylenes / Q000506:poisoning
chemical_list: D012997:Solvents; D013343:Styrenes; D014992:Xylenes; D002857:Chromium; D014050:Toluene; D004492:Edetic Acid