Comparison of the segregation of sheep histocompatibility genes OLA - A1, A8, B7, B9, and OLX-5 in eighteen hamster X sheep fibroblast hybrid lines.
Four OLA factors of the ovine histocompatibility complex and the OLX -5 factor were recognized in hamster cell X sheep fibroblast hybrids, by means of absorption of OLA reagents with hybrid cells. Segregation of these factors could be studied in eighteen independent hybrids. In the case described, the four OLA factors were distributed into two haplotypes isolated in some hybrids. The heterozygous OLX-5 factor was linked to only one haplotype; nevertheless a dissociation, occurred in one hybrid (relative to five simultaneous transmissions), is in agreement with a previous genetic study showing a loose linkage between the OLA complex and the OLX locus.
D000818:Animals; D002874:Chromosome Mapping; D006224:Cricetinae; D005347:Fibroblasts; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D006822:Hybrid Cells; D066298:In Vitro Techniques; D008285:Major Histocompatibility Complex; D012756:Sheep / Q000235:genetics*