[Polyamine content of liver, kidneys and tumors of rats during breast carcinogenesis induced by 7,12-dimethylbenz(a)anthracene].
The content of polyamines was determined in tissues of the liver, kidneys and tumours in the process of breast carcinogenesis induced by 7,12-dimethylbenz(a)anthracene. A decrease in the amount of spermidine is found in the liver of animals in the pretumour period and a rise in the contents of spermidine and spermine in the liver and kidneys of animals with tumour both per 1 g of wet tissue and 1 mg of RNA. In the tissue of breast carcinoma induced by 7,12-dimethylbenz(a)anthracene the content of spermidine increases as compared to its amount in the liver of normal rats and tumour-carrying animals.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D005260:Female; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism*; D011073:Polyamines / Q000378:metabolism*; D051381:Rats; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000378:metabolism
D011073:Polyamines; D013096:Spermine; D015127:9,10-Dimethyl-1,2-benzanthracene; D013095:Spermidine
Soderzhanie poliaminov v pecheni, pochkakh i v opukholiakh krys pri kantserogeneze molochnykh zhelez, indutsirovannom 7,12-dimetilbenz(a)antratsenom.