Growth hormone in the regulation of hyperlipidemia.
Plasma concentrations of triglyceride, cholesterol, and apolipoproteins A-I and B in young growth hormone deficient subjects were measured at intervals during the five weeks after initial hormone-replacement therapy. The mean concentrations of cholesterol, apolipoproteins A-I and B decreased significantly during that period: the decreases were progressive and in similar proportion to each other. Also, the amount by which apolipoprotein A-I concentration decreased was correlated with its plasmas concentration before treatment. The data suggests that growth hormone may play a role in the regulation of these three major plasma lipoprotein components and tend to suppress the development of hypercholesterolemia which has been observed in some adult growth hormone deficient subjects.
D000293:Adolescent; D000328:Adult; D016632:Apolipoprotein A-I; D001053:Apolipoproteins / Q000097:blood; D001055:Apolipoproteins B; D002648:Child; D002784:Cholesterol / Q000097:blood; D005260:Female; D013006:Growth Hormone / Q000172:deficiency / Q000627:therapeutic use*; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000150:complications*; D008297:Male; D014280:Triglycerides / Q000097:blood
D016632:Apolipoprotein A-I; D001053:Apolipoproteins; D001055:Apolipoproteins B; D014280:Triglycerides; D013006:Growth Hormone; D002784:Cholesterol