The morphologic effects of mitomycin C in mammalian urinary bladder.
This investigation was intended to determine the morphologic changes of mitomycin C. It is part of a series of experiments designed to evaluate the cytologic and histologic effects of topical chemotherapeutic agents using the FANFT experimental model system in mice. The results for mitomycin C are very similar to those previously reported for thio-tepa. The indicate that these chemicals produce few, if any, drug-specific light microscopic alterations. Rather, mitomycin C and thio-tepa apparently act as toxic substances, causing increased exfoliation, degeneration, and necrosis of urothelial cells. The implications of these findings and suggestions for future investigations are discussed.
D000287:Administration, Topical; D000818:Animals; D005200:FANFT; D005260:Female; D051379:Mice; D008809:Mice, Inbred C3H; D008937:Mitomycins / Q000008:administration & dosage / Q000494:pharmacology*; D009336:Necrosis; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy; D013852:Thiotepa / Q000008:administration & dosage / Q000494:pharmacology; D001743:Urinary Bladder / Q000187:drug effects*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000188:drug therapy
D008937:Mitomycins; D005200:FANFT; D013852:Thiotepa