IgG Fc-binding receptors on spermatozoa.
The ability of human and mouse spermatozoa to bind immunoglobulin to their surfaces was investigated by a binding assay using radioiodinated Ig. The results suggest that spermatozoa of both human and mouse origin possess Fc receptors, i.e. they have the ability to bind Fcgamma region. This association of Fc-binding receptor activity on spermatozoa surfaces is likely to raise some technical problems in certain conventional assays used to monitor the presence of membrane antigen(s) on spermatozoa.
D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G / Q000276:immunology*; D007142:Immunoglobulin gamma-Chains; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D011817:Rabbits; D011961:Receptors, Fc / Q000276:immunology*; D013094:Spermatozoa / Q000276:immunology*
D007140:Immunoglobulin Fab Fragments; D007074:Immunoglobulin G; D007142:Immunoglobulin gamma-Chains; D011961:Receptors, Fc