[Dynamics of asparaginase and adenosine deaminase activity in the liver with intraperitoneal administration of aminosol and amikin preparations of parenteral nitrogen nutrition].
In experiments with mongrel male rats the asparaginase and adenosine deaminase activities in the liver tissue and adenosine deaminase in blood serum were determined under different conditions of parenteral nutrition. The intraperitoneal administration of the preparations of parenteral nitrogen nutrition-aminosol and amikin (0.25 g of conditioned protein per 100 g of body weight) against a background of protein deficiency and exhaustion is shown to cause no changes as compared to the control of these enzymes activity in the liver tissue and blood serum. The asparaginase activity in the liver increases noticeably with the dose of aminosol and amikin up to 0.5 g of conditioned protein per 100 g of body weight and the adenosine deaminase activity undergo no essential changes. A statistically significant decrease in the adenosine deaminase activity is observed only under administration of aminosol against a background of protein deficiency. Under oral feeding of rats with amikin in the composition of protein-free (0.5 g of conditioned protein per 100 g of body weight), as distinct from its parenteral administration, the asparaginase activity in the liver is considerably lower. The adenosine deaminase activity in the liver and blood serum is not practically changed. A part of the nitrogen excreted from the organism with urea and ammonia under protein deficiency is supposed to be a product of deamination of endogenic purine and pyrimidine derivatives.
D000243:Adenosine Deaminase / Q000378:metabolism*; D000596:Amino Acids / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001215:Asparaginase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008297:Male; D009700:Nucleoside Deaminases / Q000378:metabolism*; D010288:Parenteral Nutrition; D011492:Protein Hydrolysates / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D000596:Amino Acids; D011492:Protein Hydrolysates; C018816:amikin (amino acid); C010025:aminosol; D001215:Asparaginase; D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase
Dinamika aktivnosti asparaginazy i adenozindezaminazy v pecheni pri vnutribriushinnom vvedenii preparatov parenteral'nogo azotistogo pitaniia--aminosola i amikina.