Genetic control of contact hypersensitivity. I. I-A subregion as well as non-H-2 loci codes for the gene of 2,4-dinitro-1-fluorobenzene antigen.
As a first step in determining the genetic control of contact hypersensitivity in mice, 2,4-dinitro-1-fluorobenzene (DNFB) was applied to induce ear swellings. Studies with congenic and recombinant inbred strains of mice revealed that the DNFB contact hypersensitivity is controlled by the I-A subregion, as well as non-H-2 regions. The results presented suggest that the major histocompatibility complex-linked immune response genes seem to be playing an important role in the contact hypersensitivity to the DNFB antigen.
D000818:Animals; D002874:Chromosome Mapping; D003877:Dermatitis, Contact / Q000235:genetics* / Q000276:immunology; D004139:Dinitrofluorobenzene / Q000276:immunology / Q000494:pharmacology*; D005802:Genes, MHC Class II; D005815:Genetic Code; D006183:H-2 Antigens / Q000235:genetics* / Q000276:immunology; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008811:Mice, Inbred DBA; D009578:Nitrobenzenes / Q000494:pharmacology*; D013997:Time Factors
D006183:H-2 Antigens; D009578:Nitrobenzenes; D004139:Dinitrofluorobenzene