Inhibition of the binding of 7,12-dimethylbenz [alpha] anthracene to DNA of murine epidermal cells in culture by vitamin A and vitamin C.
The effects of various derivatives of vitamin A and vitamin C on the binding of (3H)DMBA to murine epidermal cells (MEC) DNA in culture has been investigated. All-trans-retinoic acid, retinol, and retinol acetate inhibit the binding of DMBA to DNA at the nontoxic doses while 13-cis-retinoic acid dose not significantly modulate the binding of the carcinogen to DNA. Vitamin C, as well as its salt, also significantly reduces the binding of DMBA to DNA. Thus, the antitumorigenic effect of vitamins A and C may also be related to their ability to inhibit the binding of active metabolites of carcinogen to cellular DNA.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000378:metabolism*; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001551:Benz(a)Anthracenes / Q000378:metabolism*; D002478:Cells, Cultured; D004247:DNA / Q000378:metabolism*; D004817:Epidermis / Q000187:drug effects; D051379:Mice; D014801:Vitamin A / Q000031:analogs & derivatives / Q000494:pharmacology*
D001551:Benz(a)Anthracenes; D014801:Vitamin A; D015127:9,10-Dimethyl-1,2-benzanthracene; D004247:DNA; D001205:Ascorbic Acid