[Inhibition of the process of 4-nitroquinoline-1-oxide-induced DNA break repair in chronically virus-infected human cells].
Inhibition of DNA resynthesis after treatment of cell culture with 4-nitroquinoline-1-oxide was found to be due not to the induction of virus mutants repressing this system but to the selection in the cell population of cells predominantly with partially or completely defective system of reparation, or to the development of cellular reparative system because of the presence of viruses in the cell. In chronic infection of HEp-2 cells with tick-borne encephalitis, rubella, and rabies viruses the same phenomenon was observed, namely, inhibition of different stages of the reparation process, i.e. the mechanism of reparation is universal.
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology*; D002294:Carcinoma, Squamous Cell; D002460:Cell Line; D004260:DNA Repair; D006801:Humans; D007822:Laryngeal Neoplasms; D009153:Mutagens / Q000494:pharmacology*; D009600:Nitroquinolines / Q000494:pharmacology*; D011820:Rabies virus; D012412:Rubella virus
D009153:Mutagens; D009600:Nitroquinolines; D015112:4-Nitroquinoline-1-oxide
Ingibirovanie protsessa vossoedineniia razryvov DNK, indutsirovannykh 4-nitrokhinolin-1-oksidom v kletkakh cheloveka, khronicheski indutsirovannykh virusami.