A human cell-surface antigen defined by a monoclonal antibody and controlled by a gene on chromosome 12.
A murine monoclonal antibody 602-29, subclass IgG1, that recognizes an antigenic determinant expressed by most human cells is described. Immunoprecipitation and sodium dodecyl sulfate-gel electrophoresis analysis indicate that the antigenic determinant is carried by a protein with an apparent molecular weight of 21,000. The antigen is expressed by human-mouse somatic cell hybrids, and analysis of segregants that have lost human chromosomes indicates that the gene controlling expression of the 602-29 antigen is on chromosome 12.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000954:Antigens, Surface / Q000235:genetics* / Q000276:immunology; D002460:Cell Line; D002906:Chromosomes, Human, 6-12 and X / Q000648:ultrastructure*; D005354:Fibrosarcoma / Q000276:immunology*; D008040:Genetic Linkage; D006801:Humans; D005779:Immunodiffusion; D007163:Immunosorbent Techniques; D051379:Mice; D013724:Teratoma / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000954:Antigens, Surface