Lithium kinetics in single daily dosing.
The feasibility of single daily dosing of lithium carbonate was tested in eight recurrent manic-depressives being treated with lithium prophylaxis. The patients received their entire 24-h maintenance dose at 8:00 p.m. for 12 consecutive days. The suitability of single daily dosing was determined by comparing 1) lithium through levels; 2) lithium kinetic parameters of half-life, clearance, and volume of distribution; and 3) renal function parameters of serum creatinine, creatinine clearance, and mean 24-h urine output during the initial divided daily dosage trial and the subsequent single daily dosage trial. The observation of no significant changes in either serum half-lives or renal lithium clearance levels supports the conclusion that the average steady-state lithium serum concentration (Cpss) is unchanged by conversion to single daily doses. No significant changes were observed in either serum creatinine or creatinine clearance. However, a significant decrease in the 24-h urine output was noted on the single daily dose.
D000328:Adult; D001714:Bipolar Disorder / Q000097:blood / Q000517:prevention & control*; D003404:Creatinine / Q000097:blood; D004334:Drug Administration Schedule; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008094:Lithium / Q000097:blood* / Q000627:therapeutic use; D016651:Lithium Carbonate; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged
D016651:Lithium Carbonate; D008094:Lithium; D003404:Creatinine