A study of ultrastructural alterations in experimental non-A, non-B hepatitis by electron-beam analysis.
An electron-beam X-ray microanalysis was carried out on sections of liver biopsy specimens obtained from chimpanzees infected with non-A, non-B hepatitis. The microanalysis was concentrated over areas where typical derangement of the endoplasmic reticulum, with the formation of tubular forms possessing walls with electron-dense central membrane, was visualized. These tubular structures are regarded as the most notable pathological alteration in affected hepatocytes. However, the electron-probe microanalysis showed no deviation of the energy spectrum when compared with the background or control analysis.
D000818:Animals; D004577:Electron Probe Microanalysis; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006526:Hepatitis C / Q000473:pathology*; D006525:Hepatitis, Viral, Human / Q000473:pathology*; D008099:Liver / Q000648:ultrastructure*; D008854:Microscopy, Electron; D002679:Pan troglodytes