Excess dietary lysine induces hypercholesterolemia in chickens.
Lysine and arginine supplements were fed to 5-day-old chicks to test whether they would develop hypercholesterolemia in response to excess lysine in a fashion similar to mammals. Chicks developed hypercholesterolemia with a 4-5% lysine but not with arginine supplementation. These results indicate the lysine induced hypercholesterolemia is not due to anaplerotic interactions of arginine and lysine with the urea cycle.
D000818:Animals; D001120:Arginine / Q000008:administration & dosage; D001835:Body Weight / Q000187:drug effects; D002645:Chickens / Q000097:blood*; D002784:Cholesterol / Q000097:blood*; D005260:Female; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008239:Lysine / Q000008:administration & dosage*; D014508:Urea / Q000378:metabolism
D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014508:Urea; D001120:Arginine; D002784:Cholesterol; D008239:Lysine