title: [Combination chemotherapy including anablastine in disseminated breast cancer].
abstract: A course of combined therapy (adriablastin, cyclophosphan, vincristine and, in some cases, 5-fluorouracil) was given to 50 breast cancer patients with metastases of different localization. Therapy was conducted in 8 day series spaced by 3--4 week intervals; a total of 135 series were administered. Responses of varying degree was registered in 62% of cases. The said combined chemotherapy is highly effective in treatment of metastatic lesions of bones Out of 19 patients, bone reparation was observed in 8 cases (42.1%) and pronounced symptomatic and subjective improvement -- in 13 cases (68.4%). The suggested schedule of therapy has a low toxic effect and may be recommended for integration with medical practice.
mesh_terms: D001943:Breast Neoplasms / Q000188:drug therapy*; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy; D013852:Thiotepa / Q000008:administration & dosage; D013997:Time Factors; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D013852:Thiotepa; D005472:Fluorouracil
vernacular_title: Kombinirovannaia khimioterapiia, vkliuchaiushchaia adriablastin, pri rasprostranennom rake molochnoĭ zhlezy.