title: Red cell response to A23187 and valinomycine in Duchenne muscular dystrophy.
abstract: Treatment of red cells from Duchenne muscular dystrophy (DMD) patients with A23187 induced identical responses with those in controls in terms of Ca++ flux, shrinkage, ATP depletion, hypotonic lysis protection, and glycolysis stimulation. The level of RC-free calcium seemed not to be altered in DMD. Valinomycine-induced shrinkage was enhanced significantly in DMD red blood cells.
mesh_terms: D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000001:Calcimycin / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D004912:Erythrocytes / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D066298:In Vitro Techniques; D009136:Muscular Dystrophies / Q000503:physiopathology*; D011188:Potassium / Q000097:blood; D014634:Valinomycin / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D014634:Valinomycin; D000001:Calcimycin; D011188:Potassium; D002118:Calcium