[Characteristic rheograms of pathological bloods. Application to dynamic pharmacology (author's transl)].
The viscosity of normal and pathological blood samples is determined using a Couette viscometer (5.10-2s-1 less than or equal to shear rate less than to equal to 125 s-1). In different pathological cases, the rheograms show an abnormal behaviour. The viscosity curves exhibits a break between 0.1 and 1 s-1. This work shows the results obtained in the case of a patient suffering from Raynaud's disease. During therapy with lysine acetylsalycilate one observed the gradual shift of the breack to low shaer values, then, the return to a normal rheogram. In the same time, acroyanosis has completely disappeared, recovering normal nail growth.
D000368:Aged; D001241:Aspirin / Q000031:analogs & derivatives / Q000627:therapeutic use; D001809:Blood Viscosity; D005260:Female; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives / Q000627:therapeutic use; D010992:Plethysmography, Impedance; D011928:Raynaud Disease / Q000097:blood* / Q000188:drug therapy
D008239:Lysine; D001241:Aspirin; C010395:acetylsalicylic acid lysinate
Rhéogrammes caractéristiques de sangs pathologiques. Applications à pharmacologie dynamique.