Degradation of steroids by microorganisms. XVIII. The reversibility of steroid-1-dehydrogenation during microbial side chain degradation of sterols by Nocardia.
The aerobic side chain degradation of sterols often leads to mixtures of 1,4-diene and 4-ene compounds. By an additional anaerobic step a practically complete reverse reaction of the steroid-1-dehydrogenation occurs yielding only the corresponding 4-ene compound.
D000332:Aerobiosis; D000693:Anaerobiosis; D000733:Androstatrienes; D000735:Androstenedione / Q000096:biosynthesis; D002783:Cholestenones / Q000096:biosynthesis; D002784:Cholesterol / Q000378:metabolism*; D005285:Fermentation; D009161:Mycobacterium / Q000378:metabolism; D009615:Nocardia / Q000378:metabolism*; D015125:Oxyquinoline / Q000494:pharmacology
D000733:Androstatrienes; D002783:Cholestenones; D000735:Androstenedione; D015125:Oxyquinoline; D002784:Cholesterol