The in vitro metabolism of ethinyloestradiol, mestranol and levonorgestrel by human jejunal mucosa.
1 Ethinyloestradiol was extensively metabolised in vitro by human jejunal mucosa to form ethinyloestradiol sulphate. 2 The amount of conjugation was directly related to the weight of biopsy tissue. 3 The degree of conjugation of mestranol and levonorgestrel was much lower than for ethinyloestradiol suggesting that the 17-position of the steroid nucleus is relatively inaccessible for conjugation. 4 No Phase I metabolism of ethinyloestradiol or levonorgestrel was apparent in the conditions used in these experiments.
D000328:Adult; D004997:Ethinyl Estradiol / Q000378:metabolism*; D005260:Female; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism*; D016912:Levonorgestrel; D008297:Male; D008656:Mestranol / Q000378:metabolism*; D008875:Middle Aged; D009644:Norgestrel / Q000378:metabolism*
D009644:Norgestrel; D004997:Ethinyl Estradiol; D016912:Levonorgestrel; D008656:Mestranol