title: [The effect of the non-antibiotic growth stimulators, Carbadox and Cyadox, on reproduction in laboratory animals].
abstract: The effect of growth stimulators Carbadox and Cyadox was studied in laboratory rats and mice as exerted on their fertility, gravidity, embryo ontogenesis, and genetic efficacy of these drugs was also tested. In all tests one dose approaching the dose used in practice and multiple doses were administered. No antifertility effects were observed in either sex of rats, slight reduction in fertility was found in treated male mice. No teratogenic effect was observed, but both stimulators acted highly embryotoxically. Irrespective of the dose, genetic hazard occurred, influencing the first stages of spermatogenesis (spermatogony), and increasing the incidence ob abnormalities of spermatozoon heads after Carbadox treatment. In all tests Cyadox was less harmful than Carbadox. The results show that it is somewhat hazardous to use both growth stimulators in the period of animal reproduction.
mesh_terms: D000818:Animals; D002218:Carbadox / Q000494:pharmacology*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005313:Fetal Death / Q000139:chemically induced; D005333:Fetus / Q000187:drug effects; D006133:Growth Substances / Q000009:adverse effects / Q000494:pharmacology*; D008297:Male; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011810:Quinoxalines / Q000009:adverse effects / Q000494:pharmacology*; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects
chemical_list: D006133:Growth Substances; D011810:Quinoxalines; C020728:cyadox; D002218:Carbadox
vernacular_title: Ucinky neantibiotických stimulátorů růstu Karbadox a Cyadox na reprodukci laboratorních zvírat.