[Pharmacodynamic study of nitroglycerin preparations by methods of tetrapolar rheoplethysmography of the finger and impedance cardiography in ischemic heart disease].
A method of tetrapolar impedance plethysmography of the finger (TIPF) is suggested for the evaluation of the peripheral hemodynamic effect of drugs containing nitroglycerin. The method is based on the changes in the beta wave amplitude in TIPF as compared to the initial level. The central hemodynamics was studied by means of impedance cardiography (by the cardiac index) simultaneously with TIPF. The results are presented of the comparative pharmacodynamics of 6.4 mg sustac and 6.5 mg nitrong. The hemodynamic effect of sustac was higher that that of nitrong but its duration was 1--1 1/2 h shorter. Extreme variants have been demonstrated of the individual sensitivity of patients to the long-acting nitroglycerin agents.
D002307:Cardiography, Impedance / Q000379:methods*; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D003692:Delayed-Action Preparations; D005385:Fingers / Q000098:blood supply*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D005996:Nitroglycerin / Q000627:therapeutic use*; D010992:Plethysmography, Impedance / Q000379:methods*; D011674:Pulse / Q000187:drug effects
D003692:Delayed-Action Preparations; D005996:Nitroglycerin
Izuchenie farmakodinamiki preparatov nitroglitserina metodami tetrapoliarnoĭ reopletizmografii pal'tsa i impedans-kardiografii u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.