[Method of studying the pharmacodynamics of anti-angina drugs by means of repeated exercise tests].
A method for studying the effect of anti-anginal agents was elaborated. It comprises the appraisal of ST segment depression dynamics in individually dosaged physical exercise repeated in the same volume at interval of one hour after a single dose of the agent that is studied had been taken. Continuous monitoring with subsequent computer treatment was used for ECG recording and analysing. The administration of placebo in 14 patients with angina of effort had no effect on the hemodynamic parameters determining the requirements of the myocardium for oxygen or on the depth of ST segment depression during physical exercise to which the patients were repeatedly exposed for 6 hours; at the same time, a statistically significant decrease in the severity of the pain syndrome was revealed. The average deviation in the magnitude of ST segment depression during repeated exercises was 11.2%. The method may be used in approbation of drugs and selection of effective anti-anginal therapy.
D000328:Adult; D000787:Angina Pectoris / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D004562:Electrocardiography; D005080:Exercise Test; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D005996:Nitroglycerin / Q000627:therapeutic use*; D010919:Placebos
D010919:Placebos; D005996:Nitroglycerin
Metod izucheniia farmakodinamiki antianginal'nykh preparatov s pomoshch'iu povtornykh nagruzovhnykh testov.