[Influence of domperidone and metoclopramide on serum gastrin levels and gastric acid secretion (author's transl)].
The influence of Domperidone and Metoclopramide on the Serum Gastrin Level and Gastric Acid Secretion was investigated in a crossed, randomized double blind study in 12 male subjects aged 29 years on the average and presenting a healthy stomach. Neither after Domperidone nor after Metoclopramide could a significant change in Gastrin Level and Acid Secretion be observed. Since both Domperidone and Metoclopramide exert a motility promoting but not secretagogue effect on the upper gastrointestinal tract, both drugs are suitable for the treatment of disordered motility and evacuation related to ulcer disease, as well as for the treatment of postoperative gastroatonia.
D000328:Adult; D000932:Antiemetics / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000627:therapeutic use*; D004294:Domperidone; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood*; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000188:drug therapy; D013276:Stomach Ulcer / Q000188:drug therapy
D000932:Antiemetics; D001562:Benzimidazoles; D005755:Gastrins; D010880:Piperidines; D004294:Domperidone; D008787:Metoclopramide
Einfluss von Domperidon und Metoclopramid auf Serumgastrinspiegel und Magensäuresekretion.