The pharmacokinetics of cefadroxil associated with probenecid.
The effects of probenecid on the pharmacokinetic parameters of cefadroxil administered in a single dose of 500 mg are studied. The serum and urine levels of the antibiotic were determined by a microbiologic plate diffusion method. The antibiotic follows a single-compartment model. The half-life of cefadroxil in serum has an average value of 1.13 h, rising to 1.63 h when the antibiotic is associated with probenecid. The apparent distribution volume remains unmodified with a value close to 23 liters. The lag time is 0.25 h in the absence of probenecid, rising to 1.029 h in the presence of the uricosuric agent.
D000328:Adult; D001412:Bacillus subtilis / Q000187:drug effects; D001681:Biological Assay; D002434:Cefadroxil; D002506:Cephalexin / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism; D004347:Drug Interactions; D006801:Humans; D007700:Kinetics; D011339:Probenecid / Q000494:pharmacology*
D002434:Cefadroxil; D002506:Cephalexin; D011339:Probenecid