Loss of nitroglycerin from solutions to intravenous plastic containers: a theoretical treatment.
The physical instability of nitroglycerin solutions in plastic containers has been reported extensively. A systematic study of potency loss in plastic infusion bags were reported recently. This paper presents a theoretical treatment of the data and a proposed model consisting of adsorption onto the surface followed by partitioning into the plastic.
D000327:Adsorption; D002626:Chemistry, Pharmaceutical; D004349:Drug Packaging; D004355:Drug Stability; D007275:Injections, Intravenous; D005996:Nitroglycerin / Q000032:analysis*; D010969:Plastics; D012996:Solutions
D010969:Plastics; D012996:Solutions; D005996:Nitroglycerin