title: Effects of methamphetamine on novelty-seeking behaviour by mice.
abstract: The effects of several doses from 0.125-3 mg/kg of methamphetamine on the novelty-seeking behaviour of male Swiss albino mice were studied. Methamphetamine induced a dose-dependent inhibition of novelty preference. Furthermore, a dose of methamphetamine (1 mg/kg) which strongly decreased novelty preference in naive mice induced a significantly lower decrease in exploration of subjects previously exposed to novelty. These data provide some support for Berlyne's (1967) suggestion that amphetamine has a disruptive effect on exploration by producing over-arousal.
mesh_terms: D000818:Animals; D001143:Arousal / Q000187:drug effects; D005106:Exploratory Behavior / Q000187:drug effects*; D008124:Locomotion / Q000187:drug effects; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice
chemical_list: D008694:Methamphetamine