Long-term intracervical contraception with a levonorgestrel device.
An intracervical levonorgestrel-releasing mini-T device was tried as contraceptive in 100 fertile multiparous women for 3 years. This device release about 10 micrograms/day. The results were compared with those of an intrauterine levonorgestrel device and copper-T-200 (Cu-T-200). The continuation rates of the three device did not reveal any significant differences at 1, 2 and 3 years. Incidence of unintended pregnancies and removals due to bleeding and pain was comparable to those of Cu-T-200 but higher than those of intrauterine levonorgestrel device. The number of days of bleeding and spotting for both levonorgestrel devices was significantly lower than those for Cu-T-200.
D000328:Adult; D001706:Biopsy; D002582:Cervix Mucus / Q000032:analysis; D002584:Cervix Uteri / Q000473:pathology; D003271:Contraceptive Agents, Female / Q000008:administration & dosage*; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D007434:Intrauterine Devices / Q000009:adverse effects; D007435:Intrauterine Devices, Copper / Q000009:adverse effects; D016912:Levonorgestrel; D008598:Menstruation / Q000187:drug effects; D009644:Norgestrel / Q000008:administration & dosage* / Q000009:adverse effects; D010146:Pain / Q000209:etiology; D011247:Pregnancy; D014626:Vaginal Smears
D003271:Contraceptive Agents, Female; D009644:Norgestrel; D016912:Levonorgestrel