Anticonvulsant activity of Althesin on experimental epilepsy.
Anaesthetic doses of Althesin were tested in rabbits using two experimental models of epilepsy: generalized (OHP; oxygen at high pressure-induced seizure) and partial (penicillin cortical-induced seizure). Althesin in both models always produced anticonvulsant activity which was more powerful in generalized convulsions. This agent was successful in preventing and treating OHP seizures. The authors conclude that a clinical history of convulsions must not be considered a contraindication to the use of this anaesthetic which has particularly useful properties for neurosurgery.
D000530:Alfaxalone Alfadolone Mixture / Q000627:therapeutic use*; D000818:Animals; D004195:Disease Models, Animal; D004569:Electroencephalography; D004828:Epilepsies, Partial / Q000188:drug therapy; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D008297:Male; D011817:Rabbits
D000530:Alfaxalone Alfadolone Mixture