[Effect of hydrocortisone on the acid hydrolase activity of the myocardium].
A study was made of the effect of hydrocortisone in doses of 10, 25 and 50 mg/kg on the activity of beta-glucosidase, beta-galactosidase and acid phosphatase in the rat heart 1, 3, 6, 12 and 24 hours after single administration of the drug. It was found that the hormone exhibited a stabilizing effect within the first hours of the experiments. Later on labilization of the lysosomal membranes of the myocardium could be observed. The increasing hydrocortisone concentrations induced dose-dependent changes in the activity of the test enzymes.
D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects*; D006854:Hydrocortisone / Q000494:pharmacology*; D006867:Hydrolases / Q000378:metabolism*; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D051381:Rats; D013997:Time Factors; D001616:beta-Galactosidase / Q000378:metabolism; D001617:beta-Glucosidase / Q000378:metabolism
D006867:Hydrolases; D000135:Acid Phosphatase; D001617:beta-Glucosidase; D001616:beta-Galactosidase; D006854:Hydrocortisone
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