Occupational asthma due to inhalation of chloramine-T. I. Clinical observations and inhalation-provocation studies.
Respiratory symptoms developed in 5 patients who were exposed to chloramine-T, a potent disinfectant used in cleaning butcheries, kitchens, and operating theaters. Skin tests, performed in 4 patients, showed an immediate type of wheal and flare reaction followed by a late-type infiltrative reaction. In 3 patients, inhalation tests with chloramine-T were done. 1 patient showed asthmatic bronchial obstruction, immediately after inhalation, followed by a late-type asthmatic reaction after some hours. 2 patients only exhibited late-type reactions, 4-8 h after challenge. The late bronchial response lasted for several hours or even days and was accompanied by leukocytosis in all 3 patients and a slight fever in 1 patient. No evidence of alveolar involvement appeared. Pre-challenge inhalation of cromoglycate in 1 patient ameliorated the late response considerably.
D000281:Administration, Intranasal; D000328:Adult; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D001985:Bronchial Provocation Tests; D002700:Chloramines / Q000009:adverse effects*; D004205:Cromolyn Sodium / Q000627:therapeutic use; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D009784:Occupational Diseases / Q000175:diagnosis / Q000209:etiology*; D013902:Radiography, Thoracic; D012129:Respiratory Function Tests; D012882:Skin Tests; D013997:Time Factors; D014105:Tosyl Compounds
D002700:Chloramines; D014105:Tosyl Compounds; C016300:chloramine-T; D004205:Cromolyn Sodium