Experimental transmission of Cytauxzoon felis from bobcats (Lynx rufus) to domestic cats (Felis domesticus).
Freshly collected blood and/or spleen homogenate from an experimentally infected Florida bobcat (Lynx rufus floridanus), which had died of feline cytauxzoonosis, was inoculated into domestic cats. All inoculated cats had clinical signs of feline cytauxzoonosis and died within 2 weeks after they were inoculated. Similar material collected from an eastern bobcat (Lynx rufus rufus) carrying an experimentally infected Cytauxzoon felis parasitemia was inoculated into domestic cats. All inoculated cats developed a parasitemia, but none developed clinical signs of disease and none died of the disease. Cats subinoculated with parasitemic cat blood also developed parasitemias and they too did not develop clinical signs of infection nor died. After carrying the blood phase of Cytauxzoon felis for various periods, the domestic cats were then challenge exposed with proven lethal Cytauxzoon inoculum of domestic cat origin. All cats died of cytauxzoonosis.
D000818:Animals; D016782:Apicomplexa / Q000302:isolation & purification / Q000472:pathogenicity*; D001769:Blood / Q000469:parasitology; D002335:Carnivora; D002371:Cat Diseases / Q000469:parasitology / Q000635:transmission*; D002415:Cats; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000469:parasitology; D011528:Protozoan Infections / Q000469:parasitology / Q000635:transmission; D011529:Protozoan Infections, Animal; D013154:Spleen / Q000469:parasitology; D014774:Virulence