Effects of excess vitamin E on rat teeth.
The purpose of this investigation was to determine if the feeding of excess vitamin E during tooth formation changes the mineral content of teeth. Purified diets containing 0, 250, and 2500 IU vitamin E per kg were fed to 15-day pregnant rats and continued during lactation and to the pups after weaning. Rats were killed at 2 and 4 weeks after weaning. Incisors and molars were weighed, ashed, and the percent of calcium, magnesium, and phosphorus was determined. Feeding of excess vitamin E (2500 IU/kg diet) had no deleterious effect on percent ash or mineral composition of rat teeth. In fact, molars from rats fed excess vitamin E had slightly higher calcium and phosphorus levels. Such differences were also apparent but to a lesser extent in the dentin and enamel composition.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005260:Female; D007774:Lactation; D008274:Magnesium / Q000378:metabolism; D008297:Male; D008903:Minerals / Q000378:metabolism*; D009805:Odontogenesis / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D010758:Phosphorus / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains; D014070:Tooth / Q000033:anatomy & histology / Q000378:metabolism*; D014810:Vitamin E / Q000008:administration & dosage / Q000494:pharmacology*
D008903:Minerals; D014810:Vitamin E; D010758:Phosphorus; D008274:Magnesium; D002118:Calcium