Synergistic effect of nitrilotriacetate on iron mobilization by desferrioxamine in vivo.
Removal of iron from biologically important ligands by desferrioxamine (DF), in vitro, is exceedingly slow because of a kinetic barrier. This kinetic barrier can be overcome by a variety of a small molecular weight anions, of which nitrilotriacetate (NTA) is a prototype. We explored the effect of NTA on DF iron mobilization in vivo. Iron mobilization was increased and the effect was synergistic.
D000085:Acetates / Q000494:pharmacology*; D000818:Animals; D001665:Binding Sites; D003676:Deferoxamine / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D007501:Iron / Q000097:blood / Q000378:metabolism* / Q000652:urine; D008353:Mannitol / Q000008:administration & dosage; D009571:Nitrilotriacetic Acid / Q000494:pharmacology*; D051381:Rats
D000085:Acetates; D008353:Mannitol; D007501:Iron; D003676:Deferoxamine; D009571:Nitrilotriacetic Acid