Mucinous gastric hyperplasia in a colony of rhesus monkeys (Macaca mulatta) induced by polychlorinated biphenyl (Aroclor 1254).
Since 1971, 45 of 259 male rhesus monkeys housed in a primate building have died of a chronic and progressive disease characterized by diarrhea, dehydration, weakness, gingivitis, emaciation, and alopecia. The principal necropsy finding in these monkeys, and in eight others killed for experimental purposes, was hypertrophic and hyperplastic mucinous gastropathy involving both the mucosa and submucosa. The toxic agent involved was identified as the polychlorinated biphenyl (PCB), Aroclor 1254. The suspected source of the toxic agent was a concrete sealer used during building construction.
D000818:Animals; D000830:Animals, Laboratory; D001140:Aroclors / Q000506:poisoning*; D020111:Chlorodiphenyl (54% Chlorine); D003252:Construction Materials; D004781:Environmental Exposure; D006799:Housing, Animal; D006965:Hyperplasia; D008251:Macaca; D008253:Macaca mulatta; D008297:Male; D008992:Monkey Diseases / Q000139:chemically induced* / Q000473:pathology; D011078:Polychlorinated Biphenyls / Q000506:poisoning*; D013270:Stomach / Q000473:pathology*
D001140:Aroclors; D020111:Chlorodiphenyl (54% Chlorine); D011078:Polychlorinated Biphenyls