Multiple angiitis of mesenterial arteries in guinea pigs induced by intraperitoneal administration of high doses of Na2 EDTA. II. Electron microscopic study.
By application of high doses of EDTA we could induce angiitis-like lesions in the mesenterial arteries. In this paper we report the findings of electronmicroscopic investigations of these lesions. They consist of dissociation of the smooth muscle cells by scanty intermuscular spaces, probably by loosening of the basal laminae and matrix. Both endothelial cells and smooth muscle cells show minimal changes. The elastic lamellae were partially interrupted.
D000818:Animals; D004492:Edetic Acid / Q000009:adverse effects*; D006168:Guinea Pigs; D008638:Mesenteric Arteries / Q000648:ultrastructure*; D008854:Microscopy, Electron; D014657:Vasculitis / Q000139:chemically induced / Q000473:pathology*
D004492:Edetic Acid