[Clinical experience with fosfomycin in urinary tract infections (author's transl)].
Fosfomycin, an antibiotic from a new class of substances, has a bactericidal action against a broad spectrum of gram-positive and gram-negative organisms. The efficacy of fosfomycin in urinary tract infections was investigated with a dose of 15 g/day. 52 urological patients with obstructive and non-obstructive infections of the urinary tract were accepted for the study. The therapeutic success was convincing: 91% of the pathogens were eliminated from the urine, the urine was free from organisms in 84% of the patients after the treatment. 93% were clinically symptomless. The effects against Pseudomonas was very good: 8 of 9 strains present were eliminated. Unpleasant gastrointestinal side effects occurred which were dependent on the rate of infusion and usually became tolerable at a slower rate.
D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D001437:Bacteriuria / Q000188:drug therapy; D004352:Drug Resistance, Microbial; D005578:Fosfomycin / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008826:Microbial Sensitivity Tests; D014552:Urinary Tract Infections / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D005578:Fosfomycin
Klinische Erfahrungen mit Fosfomycin bei Harnwegsinfektionen.