Intestinal and hepatic morphine glucuronidation in immature and pregnant rats.
The glucuronyl transferase activity was measured in the rat liver and intestinal microsomes during the neonatal development and pregnancy using 14C-morphine as substrate. During development the hepatic glucuronyl transferase activity increased 16-fold from day 1 after birth until a maximum of 9.97 nmol/min/mg on day 20. The enzyme activity in intestinal microsomes increased only 4-fold from day 1 to 0.19 nmol/min/mg on day 30. After the peak activities were reached, there was a continuous decrease in the glucuronyl transferase activities. During pregnancy the glucuronyl transferase activity increased significantly in the liver while no change was observed in the intestinal microsomal fraction.
D000375:Aging; D000818:Animals; D005260:Female; D005965:Glucuronates / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009020:Morphine / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D011919:Rats, Inbred Strains
D005965:Glucuronates; D009020:Morphine; D014453:Glucuronosyltransferase