title: Combined factor V-VIII deficiency: a case report with studies of factor V and VIII activation by thrombin.
abstract: A new case of combined factor V-VIII deficiency is reported with in vitro studies of factors V and VIII activation by thrombin. The normal activation of factors V and VIII demonstrated in the patient's plasma and the equivalent levels of factor VIII coagulant activity and coagulant antigen support the hypothesis that a quantitative rather than qualitative defect in factors V and VIII is present in this disorder.
mesh_terms: D000328:Adult; D000941:Antigens / Q000378:metabolism; D005165:Factor V / Q000378:metabolism*; D005166:Factor V Deficiency / Q000150:complications*; D005169:Factor VIII / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D013917:Thrombin / Q000494:pharmacology; D013918:Thrombin Time
chemical_list: D000941:Antigens; D005165:Factor V; D005169:Factor VIII; D013917:Thrombin