Behavioural changes during withdrawal from desmethylimipramine (DMI). I. Interactions with amphetamine.
Amphetamine anorexia in rats was potentiated by acute pretreatment with the tricyclic antidepressant desmethylimipramine (DMI), but was not significantly different from controls following chronic DMI pretreatment. During withdrawal from DMI, amphetamine anorexia was attenuated after 2 weeks or 2 months pretreatment, but not after 1 week of treatment. The locomotor stimulant and stereotypy inducing effects of amphetamine were slightly enhanced during withdrawal from chronic DMI. The results are discussed in relation to known neurochemical actions of DMI.
D000818:Animals; D000855:Anorexia / Q000139:chemically induced*; D003891:Desipramine / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004347:Drug Interactions; D004435:Eating / Q000187:drug effects; D001068:Feeding and Eating Disorders / Q000139:chemically induced*; D006801:Humans; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*; D013375:Substance Withdrawal Syndrome / Q000503:physiopathology*; D013997:Time Factors
D003891:Desipramine; D003913:Dextroamphetamine; D009638:Norepinephrine