Multiple biologic activities of a cloned inducer T-cell population.
The mouse T-cell clone Ly1+2(-)/9, belonging to the Ly1 set, displays the following functions in vitro: (i) augmentation of immunoglobulin output by B cells; (ii) stimulation of bone marrow cells to produce colonies composed of granulocytes, macrophages, or both; and (iii) proliferative stimulation of T-cell clones belonging to other Ly sets. These functions are induced by Ly1+2(-)/9 cells themselves and by supernatants of Ly1+2(-)/9 cultures and are not evinced by tested clones belonging to other Ly sets. The agent or agents responsible for colony formation and for B-cell stimulation had an apparent molecular weight of 45,000-50,000 and could not be physically separated. The T-cell stimulating agent(s) had an apparent molecular weight of 30,000 and could be separated from the agent(s) that acts upon colony formation and B cells. Thus, clone LY1+2(-)/9 produces at least two soluble products that induce or augment activities of at least three other differently programmed cell sets.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002478:Cells, Cultured; D002999:Clone Cells; D006098:Granulocytes / Q000276:immunology; D007136:Immunoglobulins / Q000096:biosynthesis; D007375:Interleukin-1; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D011506:Proteins / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D007136:Immunoglobulins; D007375:Interleukin-1; D011506:Proteins