[Effect of diuretics on the distribution and renal excretion of lithium in rats of different ages].
The postnatal development of the renal lithium elimination is maturated earlier than that of renal sodium excretion. The filtered lithium is reabsorbed to a great amount in the kidney (70-80%). 90% of the administered lithium is eliminated by the kidney. Acetazolamide stimulates the renal lithium excretion in young and adult rats. Other diuretics with different sites of attack are not able to influence the elimination of lithium. Also, a forced diuresis does not change the elimination rate of lithium. The well-known interactions between sodium and ithium must have their cause in extrarenal processes.
D000375:Aging; D000818:Animals; D004232:Diuretics / Q000494:pharmacology*; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D007700:Kinetics; D008094:Lithium / Q000378:metabolism*; D016651:Lithium Carbonate; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D004232:Diuretics; D016651:Lithium Carbonate; D008094:Lithium
Der Einfluss von Diuretika auf die Verteilung und renale Ausscheidung von Lithium bei Ratten verschiedenen Alters.