Role of lactone ring of aflatoxin B1 in toxicity and mutagenicity.
Cleavage of the lactone ring of aflatoxin B1 results in a nonfluorescent compound that has greatly reduced biological activity. Mutagenicity, as measured by the Ames test, is reduced 450-fold compared to that of B1, and toxicity, as measured by the chick embryo test, is reduced 18-fold.
D016604:Aflatoxin B1; D000348:Aflatoxins / Q000633:toxicity*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D002642:Chick Embryo; D005453:Fluorescence; D007783:Lactones; D009152:Mutagenicity Tests; D012486:Salmonella typhimurium / Q000187:drug effects; D013329:Structure-Activity Relationship
D000348:Aflatoxins; D007783:Lactones; C029227:aflatoxin D1; D016604:Aflatoxin B1