Hybridomas as a source of antibodies.
Hybridomas, the progeny of fusion between antibody-secreting spleen cells and myeloma cells, produce large quantities of a single species of antibody. They are an ideal source of serologic reagents since they can be grown in tissue culture, frozen, stored, and recovered when needed. Impending applications include production of monoclonal antibodies to a wide variety of serum components and pathogens.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000302:isolation & purification*; D000951:Antigens, Neoplasm / Q000276:immunology; D002459:Cell Fusion; D003001:Cloning, Molecular; D003470:Culture Media; D006131:Growth Inhibitors; D006801:Humans; D006822:Hybrid Cells / Q000276:immunology; D007114:Immunization; D051379:Mice; D009101:Multiple Myeloma / Q000276:immunology* / Q000473:pathology; D009374:Neoplasms, Experimental / Q000276:immunology*; D013154:Spleen / Q000166:cytology
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm; D003470:Culture Media; D006131:Growth Inhibitors