Parenteral formulation of hexamethylmelamine potentially suitable for use in man.
We have developed a preparation of hexamethylmelamine (HMM), dissolved in a fat emulsion Intralipid 20%, that is potentially satisfactory for parenteral administration to man. Solid HMM can be dissolved in Intralipid 20% up to 5 mg/ml, with extensive agitation. Solubilization of HMM is facilitated first by dissolving the drug in ethanol or in dimethylacetamide and then by adding the solution to Intralipid 20%. The disposition of HMM in rabbits after iv administration of HMM dissolved in Intralipid 20% was similar to the disposition of the drug following iv administration of HMM dissolved in 0.1 N HCl.
D006585:Altretamine / Q000008:administration & dosage*; D000818:Animals; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage; D007263:Infusions, Parenteral; D007700:Kinetics; D011817:Rabbits; D012995:Solubility; D014227:Triazines / Q000008:administration & dosage*
D005217:Fat Emulsions, Intravenous; D014227:Triazines; D006585:Altretamine