[Changes in tryptophan pyrrolase activity in the rat liver after a single injection of the hepatocarcinogen 4-dimethylaminoazobenzene and its noncarcinogenic analog].
A single injection of hepatocarcinogen 4-dimethylaminoazobenzene in rats results in considerable changes of tryptophanpyrrolase of the liver. A non-carcinogenic analog 4-diethylaminoazobenzene causes similar, although a milder shift. The observed injury of definitive hepatocytes and proliferation of oval and transition cells, due to the toxic effect of both the agents, may be one of the causes of changes in tryptophan pyrrolase activity.
D000818:Animals; D001391:Azo Compounds / Q000494:pharmacology*; D007274:Injections, Intraperitoneal; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D013997:Time Factors; D014366:Tryptophan Oxygenase / Q000378:metabolism*; D010128:p-Aminoazobenzene / Q000031:analogs & derivatives / Q000494:pharmacology*; D004124:p-Dimethylaminoazobenzene / Q000494:pharmacology*
D001391:Azo Compounds; C007368:C.I. Solvent Yellow 56; D010128:p-Aminoazobenzene; D004124:p-Dimethylaminoazobenzene; D014366:Tryptophan Oxygenase
Izmenenie aktivnosti triptofanpirrolazy v pecheni krys posle odnokratnoi in"ektsii gepatokantserogena 4-dimetilaminoazobenzola i ego nekantserogennogo analoga.