Developmental changes in the fatty acids of synaptic membrane phospholipids: effect of protein malnutrition.
The acyl-linked fatty acid composition of the major phospholipid species in rat cortical synaptic membranes was determined at various stages of development. For most species there was a decrease during development in the short chain saturated fatty acids, 14:0 and 16:0, an increase in 18:0 and 22:6 (n-3) and an increase in ratio of 22:6 (n-3)/22:5 (n-6). Pups were protein deprived by feeding the dams a 12% casein diet as compared to the 24% casein control diet. Protein malnutrition markedly affected the composition of acyl-linked fatty acids in the synaptic membranes. The increases in the ratio of 22:6 (n-3)/22:5 (n-6) fatty acids were especially compromised.
D000375:Aging; D000818:Animals; D002540:Cerebral Cortex / Q000254:growth & development*; D005227:Fatty Acids / Q000378:metabolism*; D008563:Membrane Lipids / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D011502:Protein-Energy Malnutrition / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D013570:Synaptic Membranes / Q000378:metabolism*
D005227:Fatty Acids; D008563:Membrane Lipids; D010743:Phospholipids