title: Post-transplantation development of malignant lymphoma, an experimental model: syngeneic lymph node transplants.
abstract: Previously, malignant lymphomas in mice have been found to be the late sequelae of the autologous transplantation of skin grafts pretreated with CO(2); these did not occur with grafts cultured in air alone. The clinical result in this autologous system reflects environmental differences in vitro (Goldsmith & Narvaez 1975). In the present study the syngeneic transplantation in BALB/c mice of lymph node tissue resulted in the late appearance of malignant lymphomas (48-69%), irrespective of the pretransplantation treatment of the grafts. Lymph node grafts were exposed to three different environments before transplantation into syngeneic hosts: (1) to culture in air (24 hours); (2) to culture in an atmosphere of 45% CO(2) in air (24 hours); (3) direct transplantation without in vitro exposure. Transplantation of these three groups of differently treated grafts was followed by the same clinical results in their recipients. These were: (1) The development of lymphoma whereas the spontaneous incidence was zero. (2) The proliferation of T-lymphocytes in the spleen; the incidence of this abnormality correlates with the lymphoma incidence. (3) A higher than normal occurence of immune-associated lesions (amyloidosis, interstitial nephritis and myocarditis). Both syngeneic and autologous transplantations may serve as animal models for the study of clinical malignant lymphoma.
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000009:adverse effects; D002471:Cell Transformation, Neoplastic; D046508:Culture Techniques; D005260:Female; D008198:Lymph Nodes / Q000637:transplantation*; D008214:Lymphocytes / Q000473:pathology; D008223:Lymphoma / Q000209:etiology* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000209:etiology; D010100:Oxygen / Q000009:adverse effects; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen