title: [Computerized automatic management of the therapy of arterial hypertension].
abstract: On the basis of the propositions of the theory of automatic control and regulation, the authors developed the method, algorithm, and program of automatic controlled treatment of arterial hypertension by means of computers. It was conducted in 160 patients with hypertensive disease. Treatment was accomplished with reserpine, dopegit, hemiton, combination of these agents with each other and with diuretics, and with brinerdin. The effect was good in 70.6% and satisfactory in 21.9% of cases; no effect was produced in 7.5% of cases. The studies showed that the created algorithms and program make it possible to carry out effective controlled hypotensive therapy by means of computers. With the use of the developed method it was found that the tuning coefficients, and consequently, the dosages of the drugs necessary for reducing arterial pressure and its maintenance on the desirable preset level differ with the patients and in one and the same patient on different days of the treatment. Automatic controlled hypotensive therapy employing computers may be accomplished with a single agent and, whenever necessary, with a combination of several agents.
mesh_terms: D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D002986:Clinical Trials as Topic; D003000:Clonidine / Q000008:administration & dosage; D003005:Clopamide / Q000008:administration & dosage; D003201:Computers; D004088:Dihydroergotoxine / Q000008:administration & dosage; D004338:Drug Combinations / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008433:Mathematics; D008750:Methyldopa / Q000008:administration & dosage; D008875:Middle Aged; D012110:Reserpine / Q000008:administration & dosage
chemical_list: D004338:Drug Combinations; C004503:clopamide, dihydroergotoxine, reserpine drug combination; D004088:Dihydroergotoxine; D003005:Clopamide; D008750:Methyldopa; D012110:Reserpine; D003000:Clonidine
vernacular_title: Avtomaticheskoe upravlenie lecheniem arterial'noĭ gipertonii s pomoshch'iu EVM.