Infusion of vincristine-loaded platelets in acute ITP refractory to steroids: an alternative to splenectomy.
Three infusions of vincristine-loaded platelets were carried out in a young man with acute idiopathic thrombocytopenic purpura (ITP) refractory to steroids. This procedure, used until now only for chronic refractory ITP, insured a remission without side effects. After 2 years of follow-up the patient has not had relapse. A potentially dangerous splenectomy was thus avoided in a phase of the disease in which a spontaneous remission was still very probable.
D000208:Acute Disease; D000328:Adult; D001803:Blood Transfusion; D006801:Humans; D008297:Male; D010976:Platelet Count; D017713:Platelet Transfusion; D011696:Purpura, Thrombocytopenic / Q000628:therapy*; D013156:Splenectomy; D014750:Vincristine / Q000008:administration & dosage* / Q000627:therapeutic use
D014750:Vincristine