[Biochemical diagnosis of glomerular and tubulo-interstitial impairments of kidney].
Using polyacrylamide gel disc electrophoresis in presence of sodium dodecylsulfate (SDS) urinary proteins were studied in apparently healthy persons, in patients with chronic glomerulonephritis, chronic interstitial nephritis as well as in patients with myeloma, urine of which contained monoclonic light chains of immunoglobulins. SDS polyacrylamide gel disc electrophoresis is a suitable procedure for differential diagnosis of glomerular and tubulo-interstitial impairments of kidney. In some cases the procedure enables to ascertain not only the type but also severity of the kidney impairment as well as to study dynamics of the disease without a recourse to such invasive methods as kidney biopsy.
D019411:Clinical Laboratory Techniques; D004591:Electrophoresis, Polyacrylamide Gel / Q000379:methods; D005921:Glomerulonephritis / Q000175:diagnosis*; D006801:Humans; D007147:Immunoglobulin Light Chains / Q000032:analysis; D007680:Kidney Neoplasms / Q000175:diagnosis*; D009101:Multiple Myeloma / Q000175:diagnosis*; D009393:Nephritis / Q000175:diagnosis*; D011507:Proteinuria
D007147:Immunoglobulin Light Chains
Biokhimicheskaia diagnostika glomeruliarnykh i tubulointerstitsial'nykh porazheniĭ pochek.