Effect of model vascular trauma on the hepatic drug-metabolizing enzymes of the neonatal rat.
Abdominal aorta ligation in neonatal rats was used as a model for pediatric traumatic injury. Short-term ischemic trauma (24 h) was found to have significant effect on plasma corticosterone levels, and on the specific activity of the drug-metabolizing enzymes FAD-containing monooxygenase and glucuronyl transferase in hepatic microsomes. Ischemic injury was determined to cause a decrease in FAD-containing monooxygenase activity in pre-weaning animals. Glucuronyl transferase activity was increased by this surgical procedure in animals less than 12 days age, and after weaning; however, glucuronyl transferase activity was decreased by this model in rats between 14 days of age and weaning.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001012:Aorta, Abdominal / Q000502:physiology; D001808:Blood Vessels / Q000293:injuries*; D003345:Corticosterone / Q000097:blood; D005260:Female; D014453:Glucuronosyltransferase / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D014453:Glucuronosyltransferase; D003345:Corticosterone