Brief social isolation, pain responsiveness, and morphine analgesia in young rats.
Vocalizations induced by brief tail-shock were measured in young rats that were either socially or individually housed. A single day of isolation increased tail-shock-induced vocalizations, and in animals isolated 3--4 days, morphine (4 mg/kg) was less effective in reducing vocalizations than in socially housed animals. The data suggest that social contact can sustain endogenous analgesic processes in the body.
D000698:Analgesia; D000818:Animals; D004597:Electroshock; D005260:Female; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009619:Nociceptors / Q000187:drug effects; D010146:Pain / Q000523:psychology; D051381:Rats; D012934:Social Isolation; D013623:Tail; D014828:Vocalization, Animal / Q000187:drug effects
D009020:Morphine