Antigonadotropic activity of two fractions of melatonin-free pineal extract separated by ultrafiltration.
Using the mouse uterus weight test and the rat ventral prostate weight test in basal conditions and under exogenous stimulation, the activity of 2 fractions of molecular weight above and under 10,000 daltons obtained by ultrafiltration of a melatonin-free pineal extract was tested against a total pineal extract and the same extract subjected to dialysis. The results showed that the larger fraction is predominantly anti-LH whereas the smaller fraction is anti-FSH. The antigonadotropic activity of the total and partially purified pineal extract against the effects of pineal melatonin and arginine-vasotocin is discussed.
D000818:Animals; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D005260:Female; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D008297:Male; D051379:Mice; D008970:Molecular Weight; D009929:Organ Size / Q000187:drug effects; D010870:Pineal Gland / Q000502:physiology*; D011467:Prostate / Q000187:drug effects*; D051381:Rats; D013739:Testosterone / Q000494:pharmacology; D014020:Tissue Extracts / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects*
D006063:Chorionic Gonadotropin; D014020:Tissue Extracts; D013739:Testosterone; D005640:Follicle Stimulating Hormone