The influence of ovariectomy on the sex-dependent effects of the anticholinesterase diisopropyl fluorophosphate.
Temperature and water uptake were reduced to a greater degree in ovariectomized female and normal male rats than in sham-operated female rats following an acute administration of 1 mg/kg of the anticholinesterase diisopropyl fluorophosphate (DFP). Ovariectomy also led to a significant reduction in the level of serum cholinesterase activity. These findings add further support for the hypothesis that the sex-dependent effects of DFP are due, at least in part, to sex differences in serum cholinesterase activity.
D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D002369:Castration; D002802:Cholinesterases / Q000097:blood; D004326:Drinking / Q000187:drug effects*; D005260:Female; D007531:Isoflurophate / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012737:Sex Factors
D007531:Isoflurophate; D002802:Cholinesterases