The influence of the route of administration on the bioavailability of an endogenous macromolecule: chondroitin sulphate (CSA).
The absorption of chondroitin sulphate (CSA) has been investigated in rabbits after the oral administration of a single dose of 100 mg of CSA per kg of body weight. The oral dose was administered as a lipid suspension or in enteric capsules. No absorption of CSA could be demonstrated. Oral administration did not cause the release of a clearing factor into the bloodstream, a phenomenon that is known to occur in the presence of CSA. The concentration of this factor did not decrease after oral administration of CSA.
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D001702:Biopharmaceutics; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002807:Chondroitin / Q000031:analogs & derivatives*; D002809:Chondroitin Sulfates / Q000008:administration & dosage / Q000378:metabolism*; D007275:Injections, Intravenous; D007700:Kinetics; D011817:Rabbits
D002807:Chondroitin; D002809:Chondroitin Sulfates