A new synergized glutaraldehyde-phenate sterilizing solution and concentrated disinfectant.
Research leading to the development of Sporicidin, a new (synergized glutaraldehyde-phenate) sterilant and concentrated disinfectant, is reported. Microbial evaluation and shelf life testing of the new formulation was done using AOAC tests--Use-Dilution, Sporicidal, Tuberculocidal--and the E.P.A. Virucidal Test. Full-strength Sporicidin sterilizes (is sporicidal) in 6 3/4 hours at both 20C and 25C, and disinfects in 1-2 minutes. When diluted with 15 parts of tap water, Sporicidin is tuberculocidal, virucidal, and germicidal in 10 minutes, qualifying as a hospital disinfectant that will not "yellow" the hands or skin. The shelf life of activated Sporidicin, full strength or diluted 1 in 16, is 30 days. According to the data presented, which were the basis of E.P.A. registrations, Sporicidin is: (a) the fastest glutaraldehyde sterilant at room temperature, and (b) the only glutaraldehyde product that can be diluted below 2% and still qualify as a hospital disinfectant.
D000447:Aldehydes / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D004202:Disinfectants / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005976:Glutaral / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D010636:Phenols / Q000494:pharmacology*; D013171:Spores, Bacterial / Q000187:drug effects; D013242:Sterilization; D013997:Time Factors
D000447:Aldehydes; D004202:Disinfectants; D010636:Phenols; D005976:Glutaral