Somatic eye mutation in Drosophila melanogaster as a short-term test for mutagens and carcinogens.
Six mutagenic and/or carcinogenic agents were tested for their ability to cause somatic eye mutation (red sectors on a yellow eye) in Drosophila melanogaster. Results were analysed by the chi-squared method and by the Kolmogorov-Smirnov two-sample (non-parametric) test. Methyl methanesulphonate, cyclophosphamide, acriflavine and procarbazine were active, whereas acetamide and tetracycline failed to elicit a significant response. Thus, relative to other mutagenicity assays, this somatic system seemed to possess no special ability to correctly identify carcinogens because both acriflavine and acetamide were misidentified on a carcinogenicity basis. However, it could be a suitable alternative to the recessive lethal test for mutation, because of its technical simplicity and rapidity, subject to an increase in the size of the data base.
D000081:Acetamides / Q000494:pharmacology; D000818:Animals; D002273:Carcinogens / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000033:anatomy & histology / Q000235:genetics*; D005123:Eye / Q000033:anatomy & histology; D005260:Female; D008297:Male; D009152:Mutagenicity Tests / Q000379:methods*; D009154:Mutation; D011344:Procarbazine / Q000494:pharmacology; D012737:Sex Factors
D000081:Acetamides; D002273:Carcinogens; D011344:Procarbazine