In vitro responses of proliferating and non-proliferating cells to high doses of 17 beta-estradiol: cytochemical study.
The authors studied the effect of 17 beta-estradiol on the proliferation in vitro of chick embryo fibroblasts and human macrophages by microdensitometry, cytofluorometry, and autoradiography. For fibroblasts 17 beta-estradiol shortens the duration of the preparing period to mitosis, particularly of the synthetic phase (S) and has no effect on the duration of mitosis. For macrophages, which have temporarily lost their mitotic capacity, 17 beta-estradiol cannot induce mitotic division.
D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology*; D005347:Fibroblasts / Q000166:cytology* / Q000187:drug effects; D006801:Humans; D007399:Interphase / Q000187:drug effects*; D007700:Kinetics; D008264:Macrophages / Q000166:cytology* / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects*
D004958:Estradiol