UK-37, 248, a novel, selective thromboxane synthetase inhibitor with platelet anti-aggregatory and anti-thrombotic activity.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D002417:Cattle; D016861:Cyclooxygenase Inhibitors; D004285:Dogs; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008297:Male; D010088:Oxidoreductases / Q000037:antagonists & inhibitors*; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D012756:Sheep; D013923:Thromboembolism / Q000188:drug therapy*; D013929:Thromboxane B2 / Q000096:biosynthesis; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors*
D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D007093:Imidazoles; C029166:dazoxiben; D016718:Arachidonic Acid; D013929:Thromboxane B2; D010088:Oxidoreductases; D013930:Thromboxane-A Synthase; D007213:Indomethacin