title: Experimental augmentation of cerebral blood flow by mannitol in epidural intracranial masses.
abstract: Substantial morbidity and mortality from epidural hematomas continue to be seen in major centers. In spite of great improvement in the rapidity of diagnosis, preoperative treatment and surgical techniques are relatively unchanged. Nineteen anesthetized cats were monitored before and after creation of an epidural mass. Hydrogen clearance technique was used to calculate regional cerebral blood flow (rCBF) both ipsilateral and contralateral to the mass. The control group received no other treatment and showed a decrease in rCBF to as low as 56.8% of prior flow. The experimental group received 1 gm/kg/hr of mannitol and showed augmentation of rCBF to as high as 154.9% of prior flow (p less than 0.001). The effect was seen without increase in perfusion pressure or tissue edema. This study was designed to examine the parameters of rCBF after formation of an experimental epidural mass, and shows that rCBF can be increased as part of the preoperative resuscitation of such patients.
mesh_terms: D000818:Animals; D001783:Blood Flow Velocity; D002415:Cats; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005625:Frontal Lobe / Q000293:injuries; D006407:Hematoma, Epidural, Cranial / Q000188:drug therapy* / Q000503:physiopathology; D008353:Mannitol / Q000627:therapeutic use*; D013997:Time Factors; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D008353:Mannitol