Inhibition of 5-hydroxytryptophan nephrotoxicity by alpha-difluoromethyl-dopa, an inhibitor or L-amino acid decarboxylase.
Oral and intraperitoneal treatment of rats with L-5-hydroxytryptophan (5-HTP) caused dose-dependent kidney damage characterized by increase in kidney weight, functional disturbances and focal tubular necrosis. Alpha-Difluoromethyl-DOPA (DFMD), a drug that inhibits the conversion of 5-HTP to L-5-hydroxytryptamine (5-HT) abolished the nephrotoxicity of 5-HTP.
D006916:5-Hydroxytryptophan / Q000633:toxicity*; D000818:Animals; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D051381:Rats; D012701:Serotonin / Q000378:metabolism
D012701:Serotonin; C028477:alpha-difluoromethyl-DOPA; D004295:Dihydroxyphenylalanine; D006916:5-Hydroxytryptophan