Leukotriene D4: a potent coronary artery vasoconstrictor associated with impaired ventricular contraction.
Leukotriene D4 (2 c 10(-9) mole), injected into the left circumflex coronary artery of anesthetized sheep, produced profound coronary vasoconstriction and impaired regional ventricular wall motion. This cardiac effect was neither inhibited by prior treatment of the sheep with a cyclooxygenase inhibitor nor associated with thromboxane B2 release into the coronary sinus. Intravenous FPL 55712 completely abolished the coronary vasoconstriction of leukotriene D4, but a significant reduction of regional wall shortening persisted.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002867:Chromones / Q000494:pharmacology; D003326:Coronary Circulation / Q000187:drug effects; D003331:Coronary Vessels / Q000187:drug effects*; D016861:Cyclooxygenase Inhibitors; D005260:Female; D006352:Heart Ventricles / Q000187:drug effects; D007052:Ibuprofen / Q000494:pharmacology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D013189:SRS-A / Q000494:pharmacology*; D012756:Sheep; D013929:Thromboxane B2 / Q000378:metabolism; D014661:Vasoconstriction / Q000187:drug effects*
D002867:Chromones; D016861:Cyclooxygenase Inhibitors; D013189:SRS-A; D013929:Thromboxane B2; C006312:FPL 55712; D007052:Ibuprofen