[Neuroendocrine effect of thyroliberin and its analogs].
In experiments on rats, thyroliberin (TRH) and its analogue pyroglutamyl-histidyl-prolinamide stimulating effects on the CNS were shown. They produced a decrease in some phases of the sleep duration (particularly, in the deep one) and augmented the awakening period. At the same time, the antagonistic effect of these compounds with respect to nembutal anaesthesia was seen. On the contrary, TRH analogue pyroglutamyl-seryl-glycinamide decreased the awakening time and prolonged some phases of the sleep, not exerting antagonistic action on nembutal toxic effect. Both TRH analogues did not influence TTH secretion.
D000818:Animals; D006728:Hormones / Q000494:pharmacology; D008297:Male; D009842:Oligopeptides / Q000494:pharmacology; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D012890:Sleep / Q000187:drug effects*; D013972:Thyrotropin / Q000378:metabolism; D013973:Thyrotropin-Releasing Hormone / Q000031:analogs & derivatives / Q000494:pharmacology*
D006728:Hormones; D009842:Oligopeptides; C019070:pyroglutamyl-seryl-glycinamide; D013973:Thyrotropin-Releasing Hormone; C024667:pyroglutaminyl-seryl-leucinamide; D013972:Thyrotropin; D011761:Pyrrolidonecarboxylic Acid
Neĭroendocrine éffect tiroliberina i ego analogov.