15-Hydroxy-5,8,11,13-eicosatetraenoic acid (15-HETE) formation by rabbit peritoneal tissue.
The capacity of rabbit peritoneal tissue to produce lipoxygenase metabolites from exogenous arachidonic acid has been studied. The lipoxygenase pathway of arachidonic acid in this tissue is mainly directed to 15-HETE. Preliminary experiments with peritoneal macrophages indicate that these cells, just like PMN leukocytes, may contribute to the 15-HETE formation observed in peritoneal tissue.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000096:biosynthesis* / Q000378:metabolism*; D001711:Biotransformation; D006893:Hydroxyeicosatetraenoic Acids; D066298:In Vitro Techniques; D008084:Lipoxygenase / Q000378:metabolism; D010537:Peritoneum / Q000378:metabolism*; D011817:Rabbits
D001095:Arachidonic Acids; D006893:Hydroxyeicosatetraenoic Acids; D016718:Arachidonic Acid; C025984:15-hydroxy-5,8,11,13-eicosatetraenoic acid; D008084:Lipoxygenase