Synthesis of imidazo [4,5-b] pyridine-7-carboxylic acid and some of its derivatives with expected antituberculous activity.
The title acid 2 and its methyl ester 3, hydrazide 4, hydrazone 5, amide 6, nitrile 7, amidoxime 8 and thioamide 9 have been obtained. As a result of methylation of 2 with diazomethane N-CH3 derivatives of these compounds 10-17 were obtained and their structure was preliminary established as 3-CH3 compounds. Some of the obtained compounds were investigated for their tuberculostatic activity.
D000995:Antitubercular Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis*; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011725:Pyridines / Q000138:chemical synthesis*
D000995:Antitubercular Agents; D007093:Imidazoles; D011725:Pyridines