Detection of genetic variation with radioactive ligands. IV. X-linked, polymorphic genetic variation of thyroxin-binding globulin (TBG).
A genetically determined, polymorphic electrophoretic variant of thyroxin-binding alpha-globulin (TBG) is found in sera from populations of African and Oceania origin, although not in Caucasians nor Orientals. The TBG polymorphism is inherited in X-linked fashion, based on data from American blacks, and thus provides an X-chromosome marker with a relatively high gene frequency in this ethnic group (frequency of the slow allele, TBGs, is 11%). This slow variant should prove valuable in expanding the map of the X chromosome and in linkage studies. An additional family exhibiting X-linked TBG deficiency is also described.
D002874:Chromosome Mapping; D005006:Ethnicity; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers; D014644:Genetic Variation; D006801:Humans; D011110:Polymorphism, Genetic; D011869:Radioligand Assay; D012730:Sex Chromosomes; D013975:Thyroxine-Binding Proteins / Q000235:genetics*; D014960:X Chromosome
D005819:Genetic Markers; D013975:Thyroxine-Binding Proteins