title: Retardation of endochondral ossification at the distal ulnar growth plate in dogs.
abstract: Bilateral forelimb deformities associated with retained cartilage cores in the distal ulna were diagnosed in 8 immature giant breed dogs. Five of the dogs were autopsied. Histopathological examination of the distal ulnar growth plate revealed a localised central thickening due to the accumulation of hypertrophic chondrocytes which had failed to undergo the usual development to degeneration. Also the intercellular matrix septa of this cartilage were not calcified. Projections of the abnormal cartilage even persisted into the primary spongiosa. These abnormalities in the process of endochondral ossification of the growth plate produced the lesion of retained cartilage core which was responsible for the development of forelimb deformity.
mesh_terms: D000818:Animals; D001848:Bone Diseases, Developmental / Q000000981:diagnostic imaging / Q000473:pathology / Q000662:veterinary*; D002356:Cartilage / Q000473:pathology*; D002357:Cartilage Diseases / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000000981:diagnostic imaging / Q000473:pathology*; D004285:Dogs; D005260:Female; D005552:Forelimb / Q000002:abnormalities / Q000000981:diagnostic imaging / Q000473:pathology; D006984:Hypertrophy; D008297:Male; D009999:Ossification, Heterotopic / Q000662:veterinary*; D011859:Radiography; D014457:Ulna / Q000000981:diagnostic imaging / Q000473:pathology*