The alloantibody response in the allogeneically pregnant rat. I. The primary and secondary responses and detection of Ir gene control.
We compared the primary pregnancy-induced alloantibody responses with secondary pregnancy-induced responses and with conventional immunologic responses and found there are profound differences. Conventional and secondary responses produce strong lytic sera and readily detectable immunologic memory. The primary pregnancy-induced responses lack memory and produce alloantisera or widely variable titer. Such sera were rarely directly lytic. Pregnancy-induced primary responses detect MHC Ir gene control, even when the allogeneic difference is a complete HMC haplotype. The kinetics of the primary and secondary pregnancy-induced alloantibody responses against DA were different. We conclude that the primary pregnancy-induced alloantibody response is very different immunologically from conventional and secondary pregnancy-induced alloimmunizations.
D000818:Animals; D005260:Female; D005802:Genes, MHC Class II; D006461:Hemolysis; D007106:Immune Sera / Q000494:pharmacology; D007114:Immunization; D007117:Immunization, Secondary; D007156:Immunologic Memory; D007518:Isoantibodies / Q000096:biosynthesis* / Q000235:genetics; D008297:Male; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew; D013045:Species Specificity
D007106:Immune Sera; D007518:Isoantibodies