[Classification of precipitates formed by meningococcal group antigens during counterimmunoelectrophoresis].
In counter immunoelectrophoresis (CIE) of group meningococcal polysaccharides and meningococcal diagnostic group-specific antisera the manifestation of precipitate formation depended on the concentration of the antigen: with the increase of the group polysaccharide concentration the reaction became less pronounced up to complete disappearance of the precipitate, which could be the cause of pseudonegative reaction. Precipitates formed in the CIE of group polysaccharides differed in their form and appearance. To evaluate the CIE results, the classification of the precipitates has been proposed by dividing them into 3 categories differing in their appearance. The category of the precipitate indicates the specificity of the reaction. CIE has allowed one to reveal the immunological heterogeneity of meningococcal group polysaccharides.
D000918:Antibody Specificity; D000942:Antigens, Bacterial / Q000145:classification* / Q000302:isolation & purification; D001428:Bacterial Vaccines / Q000276:immunology; D003378:Counterimmunoelectrophoresis; D005188:False Negative Reactions; D009345:Neisseria meningitidis / Q000276:immunology*; D011135:Polysaccharides, Bacterial / Q000145:classification* / Q000302:isolation & purification
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D011135:Polysaccharides, Bacterial
Klassifikatsiia pretsipitatov, obrazuemykh gruppovymi antigenami meningokokkov pri vstrechnom immunoélektroforeze.