The effect of prednisone on platelet function tests.
Ivy bleeding time, capillary fragility, threshold ADP concentration for secondary platelet aggregation and platelet adhesiveness were found to be unchanged by 2 d and 6 weeks of treatment with prednisone in 22 consecutive patients with collagen or haematological diseases. Initial high platelet counts were unchanged after 2 d of treatment, but after 6 weeks of treatment the increase was significant. It is concluded that in patients of this category a 6-week treatment with commonly used doses of prednisone does not significantly affect platelet function.
D000941:Antigens / Q000032:analysis; D001792:Blood Platelets / Q000187:drug effects*; D002198:Capillary Fragility; D005169:Factor VIII / Q000032:analysis / Q000276:immunology; D006801:Humans; D010973:Platelet Adhesiveness / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count; D010979:Platelet Function Tests; D011241:Prednisone / Q000627:therapeutic use*; D013997:Time Factors; D014841:von Willebrand Factor
D000941:Antigens; D014841:von Willebrand Factor; D005169:Factor VIII; D011241:Prednisone