A new series of Tc-99m-labeled hepatobiliary tracers: N'-acyl- and N'-sulfonyl ethylenediamine-N,N-diacetic acids.
Various Tc-99m-labeled N'-substituted derivatives of ethylenediamine-N,N-diacetic acid (EDDA) are evaluated as hepatobiliary imaging agents. N-substituted aromatic acyl and aromatic sulfonyl derivatives of EDDA, labeled with Tc-99m, were administered to rabbits and golden hamsters, and the distribution indicated clearance by the hepatobiliary system. N'-aromatic sulfonyl EDDAs were labeled with Tc-99m by the SnCl2 method with more than 99% yield. Clearance of Tc-99m-p-toluenesulfonyl EDDA from the blood and the liver was as rapid as that of TC-99m N-(2,6-diethylphenylcarbamoylmethyl)iminodiacetic acid (Tc-99m benzenesulfonyl EDDA lowered urinary excretion. It is concluded that the sulfonyl EDDAs provide a fruitful source for Tc-99m-labeled hepatobiliary radiopharmaceuticals.
D000818:Animals; D001659:Biliary Tract / Q000000981:diagnostic imaging* / Q000378:metabolism; D006224:Cricetinae; D004492:Edetic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D005260:Female; D008099:Liver / Q000000981:diagnostic imaging* / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D051379:Mice; D015609:Organotechnetium Compounds; D011817:Rabbits; D011877:Radionuclide Imaging; D013667:Technetium / Q000378:metabolism; D014018:Tissue Distribution
D015609:Organotechnetium Compounds; C031124:technetium Tc 99m benzoylethylenediamine-N,N-diacetic acid; C031123:technetium Tc 99m ethylenediamine-N,N-diacetic acid; C031125:technetium Tc 99m tosylethylenediamine-N,N-diacetic acid; D013667:Technetium; D004492:Edetic Acid