Urea for long-term treatment of syndrome of inappropriate secretion of antidiuretic hormone.
The efficacy of oral urea in producing a sufficiently high osmotic diuresis was tested in seven patients with the syndrome of inappropriate secretion of antidiuretic hormone. In all patients urea corrected the hyponatraemia despite a normal fluid intake. Five patients were controlled (serum sodium concentration greater than 128 mmol(mEq)/1) with a dose of 30 g urea daily, and two with 60 g daily. The patients who needed 30 g drank 1-2 1 of fluid daily, while those who needed 60 g drank up to 3.1 per day. No major side effects were noted, even after treatment periods of up to 270 days. These findings suggest that urea is a safe and efficacious treatment of the syndrome of inappropriate secretion of antidiuretic hormone.
D004341:Drug Evaluation; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000097:blood / Q000188:drug therapy* / Q000652:urine; D009994:Osmolar Concentration; D012964:Sodium / Q000097:blood; D014508:Urea / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*
D014508:Urea; D012964:Sodium