Studies on liver toxicants: influence of bromobenzene on hepatic microsomal enzymes in mice.
The effect of acute bromobenzene intoxication on drug-metabolizing liver enzymes was studied. After an oral dose of 3000 mg/kg body weight of bromobenzene, the glucuronyltransferases I and II were increased, indicating an enzyme activation by this organic solvent via membrane irritation. The mixed-function oxidases were inhibited with the exception of the ketamine N-demethylase. Microsomal lipoperoxidation was reduced whilst H2O2 formation was unchanged.
D000818:Animals; D001969:Bromobenzenes / Q000633:toxicity*; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology*; D014453:Glucuronosyltransferase / Q000378:metabolism; D006861:Hydrogen Peroxide / Q000378:metabolism; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000378:metabolism; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology*
D001969:Bromobenzenes; D008054:Lipid Peroxides; D006861:Hydrogen Peroxide; D014453:Glucuronosyltransferase