Effects of L-deprenyl on human growth hormone secretion.
The effects of L-deprenyl on L-dopa-, apomorphine- and L-tryptophan-induced growth hormone (GH) secretion were studied in thirteen healthy male volunteers. An acute 10 mg dose of L-deprenyl did not stimulate the basal GH secretion. Short-term L-deprenyl premedication significantly enhanced the L-dopa-stimulated GH release. In contrast, L-deprenyl premedication did not change the GH response to apomorphine or L-tryptophan. Potentiation of L-dopa-induced GH release by L-deprenyl indicates an increased availability of dopamine at the receptor level without a direct agonistic effect by the drug. Furthermore, L-deprenyl does not change the function of postsynaptic dopamine receptors involved in human GH release.
D000328:Adult; D001058:Apomorphine / Q000494:pharmacology; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D010627:Phenethylamines / Q000494:pharmacology*; D012642:Selegiline / Q000494:pharmacology*; D014364:Tryptophan / Q000494:pharmacology
D010627:Phenethylamines; D012642:Selegiline; D007980:Levodopa; D014364:Tryptophan; D013006:Growth Hormone; D001058:Apomorphine