title: Changes i superoxide dismutase activity and copper during development and ageing in the fruit fly Drosophila Melanogaster.
abstract: Total superoxide dismutase activity was found to increase during development of the fruit (Drosophila melanogaster) with an increase of 346% occurring between the larval and the one-day adult stage. During the adult stage total superoxide dismutase activity did not vary with age. Throughout the period of rapid increase in total superoxide dismutase there was a correspondingly rapid increase in total copper content. A continued increase in copper content during the adult stage suggested, however, that copper levels were not determining total superoxide dismutase activity during adult ageing. The cyanide-insensitive or mitochondrial superoxide dismutase reached a maximum at 8 days of age and decline by 21% between 8 and 58 days of age.
mesh_terms: D000375:Aging; D000818:Animals; D003300:Copper / Q000032:analysis / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000201:enzymology / Q000378:metabolism; D007814:Larva; D008297:Male; D013482:Superoxide Dismutase / Q000032:analysis / Q000378:metabolism*
chemical_list: D003300:Copper; D013482:Superoxide Dismutase