Drinking in goats as effect of simultaneous intravenous infusions of angiotensin (I or II) and hypertonic NaCl or mannitol.
Drinking during the simultaneous intravenous infusion of angiotensin I (AI) or II (AII) and hypertonic NaCl or mannitol was studied in the goat, and was compared to the dipsogenic responses to the separate infusion of each of these four factors. Approximately the same amount of water was drunk during the infusion of AI/NaCl, AI/mannitol and AII/NaCl. The amount was roughly equal to the sum of the amounts taken when each of two paired stimuli was infused separately. Significantly less water was drunk in response to AII/mannitol. Somewhat more water was drunk during the separate AI than during the separate AII infusion. Administration of an AI converting enzyme inhibitor completely abolished the AI contribution to drinking during the AI/NaCl infusion but did not reduce AII/NaCl drinking, indicating that the response to AI was entirely due to its conversion into AII. The possibility is discussed that the considerable difference between AI/mannitol and AII/mannitol drinking might have been the result of choroidal and/or ependymal AI converting enzyme activity.
D000803:Angiotensin I / Q000494:pharmacology*; D000804:Angiotensin II / Q000494:pharmacology*; D000809:Angiotensins / Q000494:pharmacology*; D000818:Animals; D002216:Captopril / Q000494:pharmacology; D004326:Drinking / Q000187:drug effects*; D005260:Female; D006041:Goats / Q000502:physiology*; D007263:Infusions, Parenteral; D008297:Male; D008353:Mannitol / Q000494:pharmacology*; D012462:Saline Solution, Hypertonic / Q000494:pharmacology*; D012965:Sodium Chloride / Q000494:pharmacology*
D000809:Angiotensins; D012462:Saline Solution, Hypertonic; D000804:Angiotensin II; D008353:Mannitol; D012965:Sodium Chloride; D000803:Angiotensin I; D002216:Captopril