[On the biological action of transition metal complexes. 2. The antiviral activity of 4-methyl-2-amino-pyridine-palladium-chloride (IV)].
4-methyl-2-amino-pyridine-palladiumchlorid (IV) showed an inactivation of cell-free enveloped DNA and RNA viruses in serum-free saline such as vaccinia, pseudorabies, herpes type 1, Newcastle disease and influenza virus A/fowl plague, human influenza type A and B and vesicular stomatitis viruses, and adenovirus, a naked DNA virus, too. Picorna viruses were not inactivated, the inactivation of other viruses failed in medium with 10% serum. However the replication of enveloped viruses as checked with vaccinia and fowl plague viruses was inhibited, also when the compound was present only for 1 h after infection. Contrary to this the multiplication of adenovirus was depressed only with 90%. For the inactivation of viruses high concentrations were necessary than for the inhibition of replication. Therefore more than one kind of mode of action have to be taken into consideration.
D000650:Amnion; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002460:Cell Line; D002642:Chick Embryo; D004285:Dogs; D006801:Humans; D007668:Kidney; D007739:L Cells; D009942:Organometallic Compounds; D010165:Palladium / Q000494:pharmacology*; D010847:Picolines / Q000494:pharmacology*; D014616:Vaccinia virus / Q000187:drug effects / Q000254:growth & development; D014779:Virus Replication / Q000187:drug effects*; D014780:Viruses / Q000187:drug effects* / Q000254:growth & development
D000998:Antiviral Agents; D009942:Organometallic Compounds; D010847:Picolines; D010165:Palladium; C032537:4-methyl-2-aminopyridine-palladium chloride
Uber biologische Wirkungen von Koordinationsverbindungen der Ubergangsmetalle. 2. Zur antiviralen Wirkung von 4-methyl-2-amino-pyridin-palladiumchlorid (IV).