Primary cerebral malignant lymphoma with macroglobulinemia and carcinoma of the colon.
A case of primary cerebral malignant lymphoma, immunoblastic type was reported. The immunoelectrophoresis of the patient serum showed an abnormal bow of IgM lambda type. Autopsy revealed that the cerebral lymphoma showed no extracranial spread except for adenocarcinoma of the colon with hepatic metastasis. Ultrastracturally, some of the lymphoma cells showed plasmacytoid differentiation. Immunoperoxidase study showed intracytoplasmic polyclonal immunoglobulins in non-neoplastic plasma cells around the colonic carcinoma, in the bone marrows, and spleen. However, neither IgM nor lambda light chain was found in the cerebral lymphoma cells. The source of the macroglobulinemia in this case was discussed.
D000230:Adenocarcinoma / Q000473:pathology; D000368:Aged; D001932:Brain Neoplasms / Q000097:blood / Q000276:immunology / Q000473:pathology*; D003110:Colonic Neoplasms / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008223:Lymphoma / Q000097:blood / Q000276:immunology / Q000473:pathology*; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D008258:Waldenstrom Macroglobulinemia / Q000150:complications*