Effects of glyceryl trinitrate and SIN-1A on musculature and vasculature of the dog trachea in situ.
In dog trachea in situ, perfused arterially with blood, isoprenaline, glyceryl trinitrate and N-nitroso-N-morpholinoamino-acetonitrile (SIN-1A) given intra-arterially, decreased tracheal tone which had been elevated by neostigmine and increased tracheal blood flow. Glyceryl trinitrate and SIN-1A were more effective on the tracheal musculature than on the tracheal vasculature whereas isoprenaline was equally effective on both.
D000607:Aminoacetonitrile / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D004285:Dogs; D005260:Female; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009025:Morpholines / Q000494:pharmacology; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D005996:Nitroglycerin / Q000494:pharmacology*; D009602:Nitrosamines / Q000494:pharmacology*; D014132:Trachea / Q000098:blood supply / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
D009025:Morpholines; D009602:Nitrosamines; D014665:Vasodilator Agents; C006006:N-nitrosomorpholinoaminoacetonitrile; D000607:Aminoacetonitrile; D005996:Nitroglycerin; D007545:Isoproterenol