[Effect of organophosphate pesticides on oxidative metabolism against a background of a protein-balanced and -imbalanced diet].
A study was made of the effect of acute treatment of rats with intramuscular chlorophos and trichlorometaphos in a dose of 50 mg/kg on oxidation metabolism. The animals who had received low-grade gluten protein demonstrated, in the course of injections of organophosphorous pesticides, a considerable activation of glycolytic enzymes (aldolase and lactate dehydrogenase--LDH), changes in the spectra of LDH isozymes and an increase in the activity of a non-precipitated fraction of dehydrogenases belonging to the tricarboxylic acid series. This indicates the deterioration of aerobic oxidation and compensatory increase in little effective anaerobic pathway of carbohydrate transformation. In control rats, who had received casein, a full-value protein of animal origin, the administration of pesticides gave rise to insignificant changes, which points to the protective role of balanced nutrition aimed against toxic action of organophosphorous pesticides on oxidation metabolism.
D000818:Animals; D004044:Dietary Proteins / Q000008:administration & dosage*; D004789:Enzyme Activation / Q000187:drug effects; D005634:Fructose-Bisphosphate Aldolase / Q000378:metabolism; D008239:Lysine / Q000172:deficiency; D008715:Methionine / Q000172:deficiency; D009946:Organothiophosphorus Compounds / Q000494:pharmacology*; D010088:Oxidoreductases / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D013912:Threonine / Q000172:deficiency; D014236:Trichlorfon / Q000494:pharmacology*
D004044:Dietary Proteins; D009946:Organothiophosphorus Compounds; C009532:trichlorometaphos-3; D013912:Threonine; D008715:Methionine; D014236:Trichlorfon; D010088:Oxidoreductases; D005634:Fructose-Bisphosphate Aldolase; D008239:Lysine
O vliianii nekotorykh fosfororganicheskikh pestitsidov na okislitel'nyĭ metabolizm na fone sbalansirovannogo i ne sbalansirovannogo po belku ratsiona.