Effect of methylprednisolone on experimental noncardiogenic pulmonary edema.
Methylprednisolone, 30 mg/kg body weight, was given to dogs 30 min and 4 h after injection of monocrotaline to produce noncardiogenic pulmonary edema. Control animals received monocrotaline but not corticosteroids. After 6 h the steroid-treated animals demonstrated significantly butter gas exchange and significantly less pulmonary edema. A possible mechanism of this beneficial effect of steroids is inhibition of complement-leukocyte interactions which may mediate pulmonary microvascular injury. The results lend some support to the clinical practice of short-term pharmacologic doses of steroids in noncardiogenic pulmonary edema.
D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D006439:Hemodynamics; D008775:Methylprednisolone / Q000627:therapeutic use*; D016686:Monocrotaline; D010947:Plants, Toxic; D011652:Pulmonary Circulation / Q000187:drug effects; D011654:Pulmonary Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D011763:Pyrrolizidine Alkaloids; D012674:Senecio
D011763:Pyrrolizidine Alkaloids; D016686:Monocrotaline; D008775:Methylprednisolone