The comparison of 8-hydroxyquinoline, tropolone, and acetylacetone as mediators in the labelling of polymorphonuclear leucocytes with indium-111: a functional study.
Tropolone forms a lipophilic complex with indium-111 which is capable of mediating the labelling of polymorphonuclear leucocytes (PMNs) by this isotope; labelling efficiencies are comparable with the best achieved using 8-hydroxyquinoline and acetylacetone. However, in terms of PMN chemotaxis and phagocytosis, tropolone is significantly less toxic than either of te other ligands. 8-Hydroxyquinoline was found to reduce PMN chemotaxis and phagocytosis to approximately 70% of the control values at a concentration of 20 micro M. Tropolone may prove a superior labelling reagent.
D002634:Chemotaxis, Leukocyte; D003508:Cycloheptanes; D006801:Humans; D006912:Hydroxyquinolines; D007204:Indium; D007659:Ketones; D008024:Ligands; D009504:Neutrophils; D015125:Oxyquinoline; D010422:Pentanones; D010587:Phagocytosis; D011868:Radioisotopes; D014334:Tropolone
D003508:Cycloheptanes; D006912:Hydroxyquinolines; D007659:Ketones; D008024:Ligands; D010422:Pentanones; D011868:Radioisotopes; D007204:Indium; C008790:acetylacetone; D015125:Oxyquinoline; D014334:Tropolone