Chemoprevention of mammary tumorigenesis by a combined regimen of selenium and vitamin A.
Mammary tumorigenesis induced in rats by 7,12-dimethylbenz[a]anthracene was markedly suppressed by combined dietary supplementation with sodium selenite and retinyl acetate; final tumor yield was reduced to 8% of control as compared with 51% and 36%, respectively, for selenium and retinyl acetate alone. A continuous intake of both agents was necessary to sustain the chemopreventive effect.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D004032:Diet; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D051381:Rats; D011919:Rats, Inbred Strains; D012306:Risk; D012643:Selenium / Q000627:therapeutic use*; D013997:Time Factors; D014801:Vitamin A / Q000627:therapeutic use*
D014801:Vitamin A; D015127:9,10-Dimethyl-1,2-benzanthracene; D012643:Selenium