Urinary colony-stimulating factor in acute leukemia follow-up and correlation with various phases of the disease.
Urinary colony-stimulating factor (CSF) was assayed in 19 patients with various leukemias and was monitored in various phases of acute leukemia in 3 patients. Significantly higher CSF levels were found at the onset of leukemia with a monoblastic component. Continuous monitoring of CSF in a patient with acute myelomonocytic leukemia revealed a decrease in CSF level during the remission phase, followed by a rebound to high levels preceding the clinical and hematological relapse. Concomitantly, a colony-inhibitory factor (CIF) was detected. Both CSF and CIF of this patient were isolated and partially characterized.
D000208:Acute Disease; D000328:Adult; D000368:Aged; D003115:Colony-Stimulating Factors / Q000652:urine*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007938:Leukemia / Q000097:blood*; D007948:Leukemia, Monocytic, Acute / Q000097:blood; D015470:Leukemia, Myeloid, Acute / Q000097:blood; D008074:Lipoproteins / Q000652:urine; D011506:Proteins; D013997:Time Factors
D003115:Colony-Stimulating Factors; D008074:Lipoproteins; D011506:Proteins; C016313:colony inhibiting factor