Actions and interactions of ergotamine and dihydroergocristine in rat aortic strips.
The stimulating actions of ergotamine and serotonin were compared with that of noradrenaline on the rat isolated aorta. The results are discussed in the light of those obtained on other vascular preparations. On ergotamine or noradrenaline contracted aortic strips the antagonist activity of dihydroergocristine in comparison with that of papaverine was studied. Both agents were able to induce dose-dependent relaxations.
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D004088:Dihydroergotoxine / Q000494:pharmacology*; D004347:Drug Interactions; D004878:Ergotamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology
D004088:Dihydroergotoxine; D012701:Serotonin; D010208:Papaverine; D004878:Ergotamine; D009638:Norepinephrine