A plasma factor inhibiting prostacyclin-like activity in thrombotic thrombocytopenic purpura.
The plasma from a patient with thrombotic thrombocytopenic purpura contained a low molecular weight dialysable factor which inhibited the synthesis and release or activity of prostacyclin-like activity from vascular tissue. This factor was not an immunoglobulin or complement component. Following fresh plasma infusions the ability of the patient's plasma to stimulate the release of prostacyclin-like activity returned but no clinical improvement occurred.
D000328:Adult; D000818:Animals; D011464:Epoprostenol / Q000037:antagonists & inhibitors*; D006801:Humans; D008297:Male; D010974:Platelet Aggregation; D011448:Prostaglandin Antagonists; D011697:Purpura, Thrombotic Thrombocytopenic / Q000097:blood* / Q000378:metabolism / Q000628:therapy; D011817:Rabbits
D011448:Prostaglandin Antagonists; D011464:Epoprostenol