Microanalysis and X-ray fluorescence spectrometry of platelets in diseases with elevated muscle calcium.
Electron microscopic X-ray microanalysis and X-ray fluorescence spectrometry were done on platelets from patients with Duchenne muscular dystrophy and idiopathic scoliosis (both these conditions are known to be associated with increased intramyofibre calcium). A significant increase in calcium and phosphorus concentrations was found in the dense granules and whole cells of both conditions. The findings suggest that idiopathic scoliosis like Duchenne muscular dystrophy is a multisystem disease with detectable changes in platelets.
D000293:Adolescent; D001792:Blood Platelets / Q000032:analysis*; D002118:Calcium / Q000097:blood*; D004577:Electron Probe Microanalysis; D005260:Female; D006801:Humans; D008297:Male; D009136:Muscular Dystrophies / Q000097:blood*; D010758:Phosphorus / Q000097:blood; D012600:Scoliosis / Q000097:blood*; D013052:Spectrometry, X-Ray Emission
D010758:Phosphorus; D002118:Calcium