title: [Characteristics of the mutagenic action of 1,4-bis-diazoacetylbutane on mature Drosophila melanogaster sperm].
abstract: The mutagenic action of 1,4-bis-diazoacetylbutane was studied. No dominant lethals induced by this mutagen were detected. Up to 3.61% recessive lethal mutations were observed by the Muller-5 test. Visible mutations were detected, the majority of them having been obtained in the second generation. Four visible mutations from 11 observed concerned the eye shape and belonged to the same locus "Lobe" and 3 mutations--to the "chocolate" one. This effect might be due to the loci-specific action of the 1,4-bis-diazoacetylbutane. Three cases of replicating instability, with the stabilization of either mutant or normal state of the gene were registered. Strong morphogenic action of this mutagen has been revealed.
mesh_terms: D000818:Animals; D003979:Diazonium Compounds / Q000494:pharmacology*; D004331:Drosophila melanogaster; D005799:Genes, Dominant / Q000187:drug effects; D005804:Genes, Lethal / Q000187:drug effects; D005808:Genes, Recessive / Q000187:drug effects; D008297:Male; D009030:Mosaicism / Q000187:drug effects; D009153:Mutagens; D010641:Phenotype; D013094:Spermatozoa / Q000187:drug effects*
chemical_list: D003979:Diazonium Compounds; D009153:Mutagens; C001588:bis(diazoacetyl)butane
vernacular_title: Kharakteristika mutagennogo deĭstviia 1,4-bis-diazoatstilbutana na zrelye spermii Drosophila melanogaster.