Platelet function and fibrinolytic activity after a single dose of diflunisal (Donobid).
ADP and collagen-induced platelet aggregation and parameters related to the fibrinolytic system were studied in groups of healthy persons who had ingested 500 mg of diflunisal. A single dose of diflunisal resulted in a depression of platelet function in most cases. However, the effect was limited and only of clinical relevance in patients with a defective platelet function. A frequent finding was an enhanced fibrinolytic activity in plasma and saliva 2 h after ingestion of diflunisal. In approximately one-third of the cases studied, the fibrinolytic activity in saliva rose to levels that induced clot lysis within a few minutes. This could explain the clinical observation that administration of diflunisal prior to dental surgery is followed by dry socket symptoms in one-third of the patients.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D003094:Collagen / Q000494:pharmacology; D004061:Diflunisal / Q000494:pharmacology*; D005342:Fibrinolysis / Q000187:drug effects*; D006801:Humans; D010958:Plasminogen / Q000502:physiology; D010974:Platelet Aggregation / Q000187:drug effects*; D010979:Platelet Function Tests; D012459:Salicylates / Q000494:pharmacology*; D012463:Saliva / Q000502:physiology
D012459:Salicylates; D000244:Adenosine Diphosphate; D004061:Diflunisal; D010958:Plasminogen; D003094:Collagen