Denitrosation of carcinostatic nitrosoureas by purified NADPH cytochrome P-450 reductase and rat liver microsomes to yield nitric oxide under anaerobic conditions.
D000693:Anaerobiosis; D000818:Animals; D001711:Biotransformation; D002330:Carmustine / Q000378:metabolism*; D007700:Kinetics; D008130:Lomustine / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism*; D009249:NADP / Q000378:metabolism; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D009607:Nitrosourea Compounds / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D011919:Rats, Inbred Strains; D013053:Spectrophotometry
D009607:Nitrosourea Compounds; D009569:Nitric Oxide; D009249:NADP; D008130:Lomustine; D009251:NADPH-Ferrihemoprotein Reductase; D002330:Carmustine