title: The effect of donor strain blood and ALS therapy on pancreatic islet allograft survival in the rat.
abstract: Small amounts of donor strain ACI blood injected in conjunction with minimal ALS therapy prolonged islet allograft survival in Wistar-Lewis, diabetic recipients from a mean of 8 days in nontransfused rats to a mean of more than 100 days. ACI skin grafts transplanted on long-surviving transplant-improved rats were rejected within 8 days, which suggested that "classical" tolerance was probably not the mechanism responsible for the blood-induced suppression of islet allograft rejection.
mesh_terms: D000818:Animals; D000961:Antilymphocyte Serum / Q000627:therapeutic use*; D001789:Blood Group Antigens; D001803:Blood Transfusion; D003602:Cytotoxicity, Immunologic; D006084:Graft Rejection; D007328:Insulin / Q000032:analysis; D007515:Islets of Langerhans / Q000032:analysis; D016381:Islets of Langerhans Transplantation; D008099:Liver / Q000032:analysis; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D014184:Transplantation, Homologous
chemical_list: D000961:Antilymphocyte Serum; D001789:Blood Group Antigens; D007328:Insulin