title: [Antisecretory and antiulcer activities of N-methyl-2-(2-pyridyl)-2,3,4,5,-tetrahydro-2-thiophene-carbothioamide (R.P. .40, 749) (author's transl)].
abstract: The antisecretory and antiulcerogenic effects of R.P. 40,749 were estimated in Shay Rats; for comparison, the cimetidine effects were simultaneously studied. Results demonstrated that R.P. 40,749 had potent antisecretory and antiulcerogenic effects which were, at least, 10 times more pronounced than those of cimetidine. The mechanism of action of R.P. 40,749 has not yet been determined but it seems that an anticholinergic or an H2 receptor antagonist effect should be excluded.
mesh_terms: D000818:Animals; D000897:Anti-Ulcer Agents; D002927:Cimetidine / Q000494:pharmacology; D005260:Female; D005750:Gastric Juice / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy*; D013876:Thiophenes / Q000494:pharmacology*
chemical_list: D000897:Anti-Ulcer Agents; D013876:Thiophenes; C034498:RP 40749; D002927:Cimetidine
vernacular_title: Activités antésécrétoire et anti-ulcères de N-méthyl(pyridyl-2)-2 tétrahydrothiophènecarbothioamide-2 (40 749 R.P.) chez le rat préparé selon la méthode de Shay.