Effect of muscimol, a central GABA receptor agonist, on the catalepsy, striatal homovanillic acid increase, and analgesia induced by pilocarpine in rats.
Muscimol, a structural analog of GABA, significantly potentiated pilocarpine-induced analgesia in rats, but failed to alter pilocarpine-induced catalepsy. It also failed to affect pilocarpine-elicited increase in homovanillic acid levels in the striatum. These findings suggest that the potentiation of pilocarpine-induced analgesia by muscimol is unrelated to an interaction of the GABAergic system with the striatal cholinergic or dopaminergic systems.
D000700:Analgesics; D000818:Animals; D002375:Catalepsy / Q000139:chemically induced*; D003342:Corpus Striatum / Q000378:metabolism*; D004347:Drug Interactions; D006719:Homovanillic Acid / Q000378:metabolism*; D006801:Humans; D008297:Male; D009118:Muscimol / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D010648:Phenylacetates / Q000378:metabolism*; D010862:Pilocarpine / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D011919:Rats, Inbred Strains
D000700:Analgesics; D010080:Oxazoles; D010648:Phenylacetates; D010862:Pilocarpine; D009118:Muscimol; D006719:Homovanillic Acid