Coagulation inhibitor in hypothyroidism.
A patient was referred for investigation of heavy bleeding after surgery. He showed several features of hypothyroidism but no goitre. Primary autoimmune hypothyroidism was confirmed by the finding of a low serum thyroxine concentration and a high thyrotropin concentration. Factor VIII concentration was low, and a mild coagulation inhibitor was found. The patient was treated with thyroxine and returned to normal health within a few months. The inhibitor found in this patient may have been specific for factor VIII, but the presence of coagulation inhibitors should be considered in patients with hypothyroidism.
D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D001327:Autoimmune Diseases / Q000276:immunology*; D005169:Factor VIII / Q000276:immunology*; D006801:Humans; D007037:Hypothyroidism / Q000276:immunology*; D008297:Male
D001323:Autoantibodies; D005169:Factor VIII