title: [Drug-induced disturbances of the coagulation system (author's transl)].
abstract: Side-effects of longterm therapy on the coagulation system become manifest either as hemorrhages or as an increased risk of thromboembolism. The most frequent drug-induced coagulation defect is thrombopathia. The most important drug-induced plasmatic coagulation disorders are caused by anti-coagulants and therefore predictable. In patients exposed to hemorrhage risk, non-steroidal antiphlogistics are not contraindicated since they entail inhibition of platelet aggregation and prolonged hemorrhage time. High doses of penicillin G and the semisynthetic penicillins can lead to hemorrhage in patients with renal insufficiency. Corticosteroids and contraceptives however tend to induce hypercoagulability.
mesh_terms: D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000925:Anticoagulants / Q000009:adverse effects; D001241:Aspirin / Q000009:adverse effects; D001777:Blood Coagulation / Q000187:drug effects*; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects; D064420:Drug-Related Side Effects and Adverse Reactions; D006474:Hemorrhagic Disorders / Q000139:chemically induced; D006801:Humans; D010406:Penicillins / Q000009:adverse effects; D013923:Thromboembolism / Q000139:chemically induced
chemical_list: D000305:Adrenal Cortex Hormones; D000925:Anticoagulants; D003278:Contraceptives, Oral, Hormonal; D010406:Penicillins; D001241:Aspirin
vernacular_title: Medikamentös bedingte Störungen des Gerinnungssystems.