Facilitation of shock-induced fighting following intraventricular 5,7-dihydroxytryptamine and 6-hydroxydopa.
Using a 15-s intershock interval, an increase in shock-induced fighting was observed following intraventricular 96 microgram 5,7-dihydroxytryptamine (5,7-DHT) and 90 microgram 6-hydroxydopa (6-OHdopa). The incidence of predatory mouse killing was enhanced by 5,7-DHT, but was not affected by 6-OHdopa. Pain sensitivity was increased by 6-OHdopa, but both neurotoxins produced hyperreactivity to footshock. Specific serotonin depletion was produced by 5,7-DHT and norepinephrine depletion by 6-OHdopa. The increase in shock-induced fighting could not be predicted on the basis of monoamine depletion alone, since a long intershock interval was necessary to observe this increase.
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology*; D000374:Aggression / Q000187:drug effects*; D000700:Analgesics; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D004295:Dihydroxyphenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004102:Dihydroxytryptamines / Q000494:pharmacology*; D004597:Electroshock; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D013268:Stimulation, Chemical
D000700:Analgesics; D001679:Biogenic Amines; D004102:Dihydroxytryptamines; C001388:6-hydroxydopa; D015116:5,7-Dihydroxytryptamine; D004295:Dihydroxyphenylalanine