[Incompatible SLA bone marrow graft in swine after fractional irradiation and administration of cyclosporin A].
A series of fractionated partial irradiations which consisted of either 3 gray x 6 times or 3 gray x 4 times, combined with pharmacological immunosuppression (Cyclosporin A: Cs-A) ensure a SLA semidifferent bone marrow graft in the pig. Bone marrow and peripheral blood lymphocytes chimerism was readily detectable. No graft versus host disease (GVHD) symptoms were noticed as long as Cs-A was given at a sufficient dose. However when Cs-A treatment was stopped GVHD or rejection of the graft developed rapidly.
D000818:Animals; D016026:Bone Marrow Transplantation; D006649:Histocompatibility Antigens; D007165:Immunosuppression Therapy; D008214:Lymphocytes / Q000276:immunology / Q000528:radiation effects; D011828:Radiation Chimera; D013552:Swine
D006649:Histocompatibility Antigens
Prise de moelle SLA incompatible chez le Porc après irradiations fractionées et administration de cyclosporine A.