title: Chelatable lead body burden (by calcium-disodium EDTA) and blood lead concentration in man.
abstract: The cheletable part of lead body burden was measured in 32 workers and seven office workers after an infusion test with CaNa2EDTA. The workers had been exposed to lead at a lead and zinc processing unit for one to three years (mean one year). There was good correlation (r = 0.87) between blood lead and chelatable urinary lead excretion described by the equation y = 0.07 . 10(0.46.x). From this equation it can be predicted that the generally accepted limit value for chelatable urinary lead excretion, 0.42 mumol/mmol CaNa2EDTA administered per 24 hours (3.1 mumol/24 hours or 650 micrograms/24 hours), corresponds to a blood lead concentration (PbB) of 1.7 mumol/l (or 35 micrograms/100 ml), which is lower than the commonly accepted limit value of 2.9 mumol/l (or 60 micrograms/100 ml) for occupationally lead-exposed persons. There was a better correlation between the cheletable lead excretion and the urinary ALA-excretion (r = 0.45; p less than 0.001) than between PbB and the urinary ALA-excretion (r = 0.26; p greater than 0.05).
mesh_terms: D000328:Adult; D001822:Body Burden; D002118:Calcium; D002614:Chelating Agents / Q000627:therapeutic use*; D004492:Edetic Acid / Q000627:therapeutic use*; D006801:Humans; D007854:Lead / Q000097:blood / Q000378:metabolism* / Q000652:urine; D007855:Lead Poisoning / Q000188:drug therapy; D008875:Middle Aged; D009784:Occupational Diseases / Q000188:drug therapy; D012964:Sodium
chemical_list: D002614:Chelating Agents; D007854:Lead; D004492:Edetic Acid; D012964:Sodium; D002118:Calcium