title: Simple models of pharmacological protection against induced bronchial obstruction.
abstract: The authors assessed the action of drugs against bronchial obstruction induced by inhalation of pollen allergen in 54 patients during the symptom-free period of bronchial asthma. Protection against pollen allergen was provided by disodium cromoglycate (Intal-nasal)--20 mg--in 96% of patients (P less than 0.001), by beclomethasone dipropionate (Becotide)--400 microgram--only in 17% of the investigated subjects (effect is not statistically significant) and by the antihistamine preparation Dithiaden administered by the i. v. route, 1 mg, in 46% of the patients (P less than 0.01). The authors made a detailed statistical analysis and discuss the causes of different results as regards the protective action of the investigated drugs.
mesh_terms: D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000209:etiology / Q000503:physiopathology* / Q000517:prevention & control; D001507:Beclomethasone / Q000494:pharmacology*; D001582:Benzothiepins / Q000494:pharmacology*; D001980:Bronchi / Q000187:drug effects*; D004205:Cromolyn Sodium / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008297:Male; D008450:Maximal Midexpiratory Flow Rate; D008875:Middle Aged; D012130:Respiratory Hypersensitivity / Q000150:complications; D014797:Vital Capacity
chemical_list: D001582:Benzothiepins; D001507:Beclomethasone; D004205:Cromolyn Sodium