Non-specific precipitin reactions of IgG at low ionic strength.
Precipitin reactions apparently not involving specific antibodies were obtained in immunodiffusion experiments performed at low salt concentration between IgG and the muscle proteins, actin and tropomyosin. The precipitates, which dissolved at physiologic ionic strength, may result from electrostatic interaction of molecules of different net charge and different distribution and number of charged groups.
D000199:Actins / Q000276:immunology; D000818:Animals; D001323:Autoantibodies / Q000032:analysis; D002908:Chronic Disease; D006525:Hepatitis, Viral, Human / Q000276:immunology; D006801:Humans; D005779:Immunodiffusion; D007074:Immunoglobulin G / Q000032:analysis*; D009994:Osmolar Concentration; D011234:Precipitins / Q000032:analysis*; D011817:Rabbits; D014335:Tropomyosin / Q000276:immunology
D000199:Actins; D001323:Autoantibodies; D007074:Immunoglobulin G; D011234:Precipitins; D014335:Tropomyosin