[Reactive changes in the capillaries of the mammillary bodies of the brains of aging animals].
As electron microscopic investigation of the capillary wall in the mammillary bodies has demonstrated, in old animals the number of organells in the endothelial cells decreases; discomplexion and reduction of mitochondrial crists occur, their matrix becomes cleared; myelin-like structures are formed. In pericytes pigment inclusions are accumulating. Noncellular component of the basal layer loses its regular structure and foci of hydratation appear in it. When pharmacological loadings (adrenaline, aminazine) are applied to old animals, distrophic processes in the vascular wall increase; that results in disturbance of permeability, sharp hydratation of the basal layer, edema of the tissue elements around the brain and, hence, in a more prolonged restorative period.
D000375:Aging; D000818:Animals; D002196:Capillaries / Q000648:ultrastructure; D002199:Capillary Permeability / Q000187:drug effects; D002746:Chlorpromazine / Q000494:pharmacology; D004727:Endothelium / Q000648:ultrastructure; D004837:Epinephrine / Q000494:pharmacology; D008297:Male; D008326:Mammillary Bodies / Q000098:blood supply*; D008854:Microscopy, Electron; D051381:Rats
D002746:Chlorpromazine; D004837:Epinephrine
Reaktivnye izmeneniia kapilliarov sostsevidnykh tel mozga starykh zhivotnykh.