title: Antituberculosis activity of 6 cyclo-octylamino-5,8-quinolinequinone (CQQ).
abstract: A new compound, 6 cyclo-octylamino-5,8-quinolinequinone (CQQ), a dual analogue of vitamin K and coenzyme Q, was effective against several drug-susceptible and drug-resistant strains of Mycobacterium tuberculosis. In vitro studies indicated the bactericidal nature of its action at 1 microgram/ml. Pulse exposure studies using M. tuberculosis H37Rv showed that a growth lag period of 96 hours resulted with exposure to 1 microgram/ml for 24 hours or longer.
mesh_terms: D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D011804:Quinolines / Q000494:pharmacology*; D015363:Quinolones
chemical_list: D011804:Quinolines; D015363:Quinolones; C031241:6-(cyclooctylamino)-5,8-quinolinequinone