Uptake of lysosomal enzymes by human fibroblasts: lack of uptake of fungal or plant glycosidases in comparison with a mammalian enzyme.
alpha-Galactosidase from human placenta was actively taken up by cultured fibroblasts from patients with Fabry's disease whereas the enzyme from the fig was not absorbed. alpha-Glucosidase from two microbiological sources. A. fumigatus and A. niger, was not taken up by cultured fibroblasts from patients with Pompe's disease.
D001230:Aspergillus / Q000201:enzymology*; D000795:Fabry Disease / Q000201:enzymology; D005347:Fibroblasts / Q000201:enzymology*; D005696:Galactosidases / Q000378:metabolism*; D005959:Glucosidases / Q000378:metabolism*; D006009:Glycogen Storage Disease Type II / Q000201:enzymology; D006801:Humans; D010920:Placenta / Q000201:enzymology*; D012867:Skin / Q000201:enzymology
D005696:Galactosidases; D005959:Glucosidases