title: Glycosaminoglycan content and cell density of rabbit articular cartilage in experimental lipoarthrosis.
abstract: Glycosaminoglycan content and cell density of articular cartilage have been studied quantitatively in the adult rabbit in experimental lipoarthrosis. On the fourth day after injection of non-radioactive or tritium-labelled glyceryl trioleate into the synovial cavity of the knee joint, femoral condylar cartilage shows no change in cellularity. There is a 35% loss of chondroitin sulphate from the matrix, but little change in keratansulphate. The results are not affected by the presence or absence of radioactive isotope in the lipid: possible mechanisms accounting for glycosaminoglycan loss are discussed.
mesh_terms: D000818:Animals; D001168:Arthritis / Q000139:chemically induced / Q000473:pathology; D002358:Cartilage, Articular / Q000378:metabolism* / Q000473:pathology; D002452:Cell Count; D002809:Chondroitin Sulfates / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism*; D007592:Joint Diseases / Q000378:metabolism*; D007632:Keratan Sulfate / Q000378:metabolism; D011817:Rabbits
chemical_list: D006025:Glycosaminoglycans; D002809:Chondroitin Sulfates; D007632:Keratan Sulfate