Microsomal activation of selected polycyclic aromatic hydrocarbons and aromatic amines in Drosophila melanogaster.
Benzo[a]pyrene, 7,12-dimethylbenz[a]anthracene, 2-acetylaminofluorene, 2-aminoanthracene, and 1-aminopyrene, when fed to adult Drosophila melanogaster males, gave a negative mutagenic response in the X-linked recessive lethal assay. Benzo[a]pyrene was also ineffective in inducing "Minutes". Aflatoxin B1, EMS and DMN gave a positive response which was dependent on the concentration of mutagen fed. Whole fly homogenates prepared from adult Drosophila were assayed for mixed-function oxidase activity in the Salmonella/microsome test. Crude Drosophila microsomes activated 2-acetylaminofluorene, 2-aminofluorene, 2,7-diaminofluorene, 2-aminoanthracene, 1-aminopyrene, and aflatoxin B1. Tests with benzo[a]pyrene, pyrene, 1,2,3,4-dibenz[a]anthracene, and 7-12-dimethylbenz[a]anthracene were negative.
D000818:Animals; D001711:Biotransformation; D004331:Drosophila melanogaster / Q000235:genetics; D008861:Microsomes / Q000378:metabolism*; D009152:Mutagenicity Tests; D009153:Mutagens; D011083:Polycyclic Compounds / Q000378:metabolism* / Q000494:pharmacology
D009153:Mutagens; D011083:Polycyclic Compounds