Effect of acute hypoxemia and respiratory acidosis on the fetal heart rate in monkeys.
The fetal heart rate (FHR) response to acute nonacidemic hypoxemia and to acute respiratory acidosis was studied in unanesthetized pregnant monkeys by means of chronically implanted catheters and electrodes. Average FHR and short- and long-term FHR variability were analyzed separately. The FHR response to either hypoxemia or hypercapnia consisted of slowing and increased variability. The slowing was more consistent with hypercapnia than with hypoxemia. Long-term FHR variability increased with both test stresses. The increase in short-term FHR variability was much greater in response to hypoxemia than to hypercapnia. Both the FHR slowing and the increases in variability in response to the test stresses were reduced by prior administration of atropine to the fetus.
D000142:Acidosis, Respiratory / Q000503:physiopathology*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002245:Carbon Dioxide / Q000494:pharmacology; D005260:Female; D005318:Fetal Heart / Q000187:drug effects / Q000502:physiology*; D006339:Heart Rate / Q000187:drug effects; D006935:Hypercapnia / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology*; D008253:Macaca mulatta; D011247:Pregnancy
D002245:Carbon Dioxide; D001285:Atropine