Pharmacokinetics of gold following administration of auranofin (SK+FD-39162) and myochrysine to rats.
Auranofin orally administered to rats resulted in delayed and protracted peak blood and serum gold levels occurring 24 to 48 h post administration. During this period, the gold concentration in blood was higher than in serum indicating that a major portion of gold was associated with the cellular components. During 1st order elimination (greater than 48 h), the blood/serum gold ratio decreased which suggested dissociation of cellular gold. Biliary cannulation experiments demonstrated that the protracted gold levels (24 to 48 h) could not be due to hepatic recirculation. In contrast to auranofin, gold sodium thiomalate produced blood gold levels which peaked within 3 h, rapidly declined and were consistently lower than serum gold levels.
D000818:Animals; D001310:Auranofin; D006051:Aurothioglucose / Q000008:administration & dosage / Q000031:analogs & derivatives*; D001659:Biliary Tract / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006046:Gold / Q000031:analogs & derivatives* / Q000378:metabolism*; D006052:Gold Sodium Thiomalate / Q000008:administration & dosage*; D007700:Kinetics; D010720:Phosphines / Q000008:administration & dosage; D051381:Rats
D010720:Phosphines; D006052:Gold Sodium Thiomalate; D006051:Aurothioglucose; D001310:Auranofin; D006046:Gold