title: A possible method for improving the efficacy of dapsone.
abstract: The antileprosy drug dapsone is unable to penetrate intact Mycobacterium leprae in vitro, as determined by its effect on o-diphenoloxidase in the bacilli. When combined with the peptide polylysine, the sulfone drug passes through the bacterial cell membranes, and penetrates the enzyme protein, resulting in a 100% inhibition of its activity.
mesh_terms: D004156:Catechol Oxidase / Q000037:antagonists & inhibitors*; D002463:Cell Membrane Permeability / Q000187:drug effects; D003622:Dapsone / Q000008:administration & dosage* / Q000494:pharmacology; D004338:Drug Combinations; D006863:Hydrogen-Ion Concentration; D009166:Mycobacterium leprae / Q000201:enzymology*; D010455:Peptides / Q000627:therapeutic use*; D011107:Polylysine / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D010455:Peptides; D011107:Polylysine; D003622:Dapsone; D004156:Catechol Oxidase