title: Metabolic and immune effects of arginine in postinjury hyperalimentation.
abstract: Nitrogen balance and thymic immune function studies were carried out in rats subjected to anesthesia, jugular vein catheterization, and bilateral femoral fractures, who were then given for 5 days: A) D5W; B) D20 FreAmine II (total arginine 1.55 gm/L); or C) D20 FreAmine III (4.05 gm of arginine/L). Administration of hypercaloric amino acid mixtures had strong positive effects on nitrogen retention and thymic function when compared to isotonic dextrose infusion. The administration of solution C had the most positive effect on nitrogen balance and on thymic immune function. The data suggest that increased arginine administration may prove beneficial to injured patients.
mesh_terms: D000596:Amino Acids; D000818:Animals; D001120:Arginine / Q000494:pharmacology*; D001769:Blood; D005260:Female; D009584:Nitrogen / Q000378:metabolism; D009929:Organ Size; D010288:Parenteral Nutrition; D010289:Parenteral Nutrition, Total; D051381:Rats; D011919:Rats, Inbred Strains; D013950:Thymus Gland / Q000276:immunology; D014947:Wounds and Injuries / Q000276:immunology / Q000378:metabolism / Q000628:therapy*
chemical_list: D000596:Amino Acids; D001120:Arginine; D009584:Nitrogen