title: [Experimental use of antitumor preparations in low doses].
abstract: The susceptibility of tumor tissue to therapeutic and smaller doses of chemotherapeutic drugs was assessed on the basis of SH-group inhibition in vitro. As therapeutic dose was decreased, rhythmic changes of tumor susceptibility were observed. In the experiments on tumor-bearing rats, the small dose of chemotherapeutic agent, which in preliminary in vitro experiments proved to be as effective as therapeutic one (1/5 therapeutic dose), was found to cause the same suppression of tumor growth. However, it did not induce leukopenia, lymphopenia, thymus involution or any other manifestations of stress which followed multiple injections of therapeutic doses. The white blood cell and thymus indices in rats, which received the small dose, suggest the development of reactions of training and activation which increase the nonspecific resistance of organism.
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D002277:Carcinoma / Q000188:drug therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004351:Drug Resistance; D066298:In Vitro Techniques; D008297:Male; D008558:Melphalan / Q000008:administration & dosage; D009374:Neoplasms, Experimental / Q000188:drug therapy; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy; D013852:Thiotepa / Q000008:administration & dosage
chemical_list: D000970:Antineoplastic Agents; D003520:Cyclophosphamide; D013852:Thiotepa; D008558:Melphalan
vernacular_title: O primenenii v éksperimente protivoopukholevykh preparatov v malykh dozakh.