Lack of effect of the peptide pyro-Glu-His-Gly-OH on food consumption in mice and rats.
1. Single subcutaneous injections (0.5-10 mg/kg) or repeated oral administration (5 mg/kg, twice daily for 3 or 5 days) of the proposed anorexigenic peptide pyro-GLU-HIS-GLY-OH did not affect food intake in the mouse. 2. Single intravenous injections (0.05-1 mg/kg) or daily intravenous injections (0.3-10 mg/kg, for 5 days) of pyro-GLU-HIS-GLY-OH did not affect food intake in the rat. 3. These results, together with results obtained recently by other workers, indicate that pyro-GLU-HIS-GLY-OH does not have anorexigenic properties in rodents.
D000818:Animals; D001067:Appetite Depressants; D003913:Dextroamphetamine / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects; D008297:Male; D051379:Mice; D009842:Oligopeptides / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D011919:Rats, Inbred Strains; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D001067:Appetite Depressants; D009842:Oligopeptides; D013973:Thyrotropin-Releasing Hormone; C023866:pyroglutamyl-histidyl-glycine; D011761:Pyrrolidonecarboxylic Acid; D003913:Dextroamphetamine