Chronic myeloproliferative disorders: a quantitative assessment of platelet ultrastructure.
In patients with chronic myeloproliferative disorders (MPD) and impaired in vitro platelet aggregation, a quantitative assessment of platelet ultrastructure showed reduced numbers of alpha granules and excessive dilation of the open canalicular systems. After 10 days of aspirin therapy, some abnormalities were significantly reduced. The implications of this finding are discussed.
D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use; D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure*; D002908:Chronic Disease; D003594:Cytoplasmic Granules / Q000187:drug effects / Q000648:ultrastructure; D006801:Humans; D009196:Myeloproliferative Disorders / Q000097:blood* / Q000188:drug therapy; D010974:Platelet Aggregation
D001241:Aspirin