Mathematical modelling of intravascular thyroid hormone stimulation by carrier proteins.
A simple mathematical model for the thyroid hormone stimulation in plasma after intravenous administration of pharmacological doses of thyroid hormone binding carrier proteins is described. The model concept is based on the observation of the time course of both radioactive labelled and unlabelled thyroid hormones before and after protein loading in rabbits. All model parameters are derived from experimental measurements in order to guarantee the identifiability with physiological data. The presented initial study could be a theoretical basis for a more effective therapy of thyroid storm by dialysis or plasma exchange methods.
D000818:Animals; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D011817:Rabbits; D013963:Thyroid Hormones / Q000097:blood*; D013974:Thyroxine / Q000097:blood; D013975:Thyroxine-Binding Proteins / Q000378:metabolism / Q000494:pharmacology*; D014284:Triiodothyronine / Q000097:blood
D013963:Thyroid Hormones; D013975:Thyroxine-Binding Proteins; D014284:Triiodothyronine; D013974:Thyroxine