Effects of adjuvants on the immunogenicity of Habu-venom toxoid in the monkey and the guinea pig.
Incorporation of aluminum adjuvant as large an amount as 1 mg/ml (as Al) in immunization was required to produce high antibody titers against Habu-venom toxoid. The adjuvanticity of aluminum hydroxide was superior to that of aluminum phosphate. When used in combination with poly-L-lysine, a smaller amount of aluminum was needed to produce the same level of antibody titer as that produced with aluminum alone.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000535:Aluminum / Q000494:pharmacology; D000818:Animals; D003435:Crotalid Venoms / Q000276:immunology*; D006168:Guinea Pigs; D000882:Haplorhini; D011107:Polylysine / Q000494:pharmacology; D014121:Toxoids / Q000276:immunology*
D000276:Adjuvants, Immunologic; D003435:Crotalid Venoms; D014121:Toxoids; D011107:Polylysine; D000535:Aluminum