Erythrocyte deformability in dialysed and non-dialysed uraemic patients.
In thirty-one uraemic patients, fourteen on conservative treatment and seventeen on long-term haemodialysis, erythrocyte deformability, measured as filtration half-time in a paper filtration experiment, was studied. The two groups were comparable concerning age, sex and kidney disease. Although the mean filtration half-time for erythrocyte suspensions was normal in non-dialysed patients there was a positive linear correlation (P less than 0.01) between serum creatinine and filtration half-time in this group. Filtration half-time was increased in dialysed patients, indicating impaired deformability in the latter (P less than 0.001). Filtration half-time showed a good inverse correlation with the packed red cell volume in the non-dialysed (P less than 0.001) and in the dialysed group (P less than 0.01). As pre- and post-dialysis filtration half-times were the same, it appeared that the more severe uraemic state of dialysed patients was responsible for the impairment of erythrocyte deformability and not the dialysis procedure itself.
D000328:Adult; D000368:Aged; D001772:Blood Cell Count; D004909:Erythrocyte Indices; D004913:Erythrocytes, Abnormal / Q000166:cytology*; D005260:Female; D005374:Filtration; D006400:Hematocrit; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012156:Reticulocytes; D013997:Time Factors; D014508:Urea / Q000097:blood; D014511:Uremia / Q000097:blood* / Q000628:therapy
D014508:Urea