Synthesis of amidrazones from 2-ethoxycarbonyl-4H-3,1-benzoxazin-4-one.
Hydrazine, phenylhydrazine and carboxylic acid hydrazides underwent an addition reaction to the 1,2 double bond of 2-ethoxycarbonyl-4H-3, 1-benzoxazin-4-one with ring opening to give oxalamidrazone derivatives. Preliminary screening of these amidrazones showed that some of the synthesized compounds exhibited antitubercular activity.
D000995:Antitubercular Agents / Q000138:chemical synthesis*; D048588:Benzoxazines; D055598:Chemical Phenomena; D002621:Chemistry; D006835:Hydrazones / Q000138:chemical synthesis*; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D010078:Oxazines
D000995:Antitubercular Agents; D048588:Benzoxazines; D006835:Hydrazones; D010078:Oxazines; C033881:2-ethoxycarbonyl-4H-3,1-benzoxazin-4-one