Thyroliberin (thyrotropin releasing hormone): antagonism of halothane and hexobarbital narcosis in mice. Comparison with pentetrazol, caffeine, d-amphetamine and adrenaline.
The effect of L-pyroglutamyl-L-histidyl-L-prolinamide (thyroliberin, thyrotropin releasing hormone, TRH) on halothane and hexobarbital narcosis was investigated in mice and compared with pentetrazol, caffeine, d-amphetamine and adrenaline. TRH shortened dose-dependently the halothane and hexobarbital sleeping-time with ED50 values of 3.1 and 6.6 mg/kg s.c., respectively. The analeptic effect of TRH was superior to all reference compounds in terms of potency, efficacy and drug safety. Due to its ergotropic activity TRH may be a useful aid in anaesthesiology and intensive care.
D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D003913:Dextroamphetamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology*; D006221:Halothane / Q000037:antagonists & inhibitors*; D006591:Hexobarbital / Q000037:antagonists & inhibitors*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010433:Pentylenetetrazole / Q000494:pharmacology*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D002110:Caffeine; D013973:Thyrotropin-Releasing Hormone; D006591:Hexobarbital; D003913:Dextroamphetamine; D006221:Halothane; D010433:Pentylenetetrazole; D004837:Epinephrine