title: Metabolism of serine, glycine and threonine in isolated cat hepatocytes Felis domestica.
abstract: 1. Hepatocytes isolated from the cat demonstrate differences with regard to amino acid metabolism as compared to rat hepatocytes. 2. [14C]serine is metabolized via transamination in isolated cat hepatocyte, whereas its major catabolic route in the rat is via serine dehydratase. 3. [14C]glycerine, a poor gluconeogenic precursor in rat hepatocytes, appears to be equal to serine as a precursor for cat hepatocytes. 4. [14C]threonine does not compete with serine for metabolism, and may be metabolized via threonine aldolase. 5. These results illustrate a protection of amino acids from oxidative metabolism, and a high priority for their metabolism towards anabolic processes.
mesh_terms: D000818:Animals; D001711:Biotransformation; D002415:Cats / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D005998:Glycine / Q000378:metabolism*; D066298:In Vitro Techniques; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D008099:Liver / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D012694:Serine / Q000378:metabolism*; D013912:Threonine / Q000378:metabolism*
chemical_list: D007773:Lactates; D013912:Threonine; D019344:Lactic Acid; D012694:Serine; D005947:Glucose; D005998:Glycine