[Efficacy of schistosomicide derivatives, appreciation with electronic microscopy experimental model (author's transl)].
The activity of some schistosomicidal drugs have been studied by electron microscopy on the tegument of Schistosoma mansoni. Results are different and depend of the compound which is tested. Two new compounds: RO 11 3128 and RO 13 3978 are specially active and act in different ways on the tegument. On of them, a benzodiazepine, have been tested in association with an "antibenzodiazepine" compound in order to avoid the sedative action without decrease of the schistosomicidal activity.
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D005442:Flumazenil; D051379:Mice; D008854:Microscopy, Electron; D012550:Schistosoma mansoni / Q000187:drug effects* / Q000648:ultrastructure; D012556:Schistosomicides / Q000494:pharmacology*; D002998:Clonazepam / Q000031:analogs & derivatives
D001570:Benzodiazepinones; D005442:Flumazenil; D012556:Schistosomicides; C020602:meclonazepam; D002998:Clonazepam
Appréciation de l'activité de dérivés schistosomicides en microscopie électronique.