Endocrine function of the heterotopic pancreatic allotransplant in dogs. II. Immediate post-transplant period.
Pancreatic endocrine function was investigated in dogs after heterotopic pancreatic allotransplantation. A marked hyperinsulinemia was found in peripheral venous blood within the first 60 min postoperatively. This was associated with hypoglycemia and hypokalemia occurring within the next 2 to 3 hr resulting eventually in death. The hypoglycemia could be corrected by parenteral dextrose and potassium given during the first 2 hr postoperatively or prevented by parenteral hydrocortisone given at the time of transplantation.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004285:Dogs; D005260:Female; D007328:Insulin / Q000097:blood*; D007515:Islets of Langerhans / Q000502:physiology; D016381:Islets of Langerhans Transplantation; D008297:Male; D011188:Potassium / Q000097:blood*; D013997:Time Factors; D014184:Transplantation, Homologous
D001786:Blood Glucose; D007328:Insulin; D011188:Potassium