Kinetics of 51CrEDTA in the rat.
The kinetics of 51Cr EDTA in the rat has been analysed. A single bolus injection after an equilibration period of 30 min, resulted in a steep monoexponential plasma clearance (T 1/2 = 40.8 +/- 4.3 min). To facilitate estimation of the EDTA space, renal clearance was eliminated by renal vascular ligation. The extrarenal clearance of EDTA was very slow (T 1/2 approximately 800 min) according to a linear function. The EDTA space was 25.7 +/- 1.8 ml/100 g body weight. The EDTA space is considered to measure the extracellular fluid volume.
D000818:Animals; D002860:Chromium Radioisotopes; D004492:Edetic Acid / Q000008:administration & dosage / Q000378:metabolism*; D005110:Extracellular Space / Q000378:metabolism; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism; D013997:Time Factors
D002860:Chromium Radioisotopes; D012709:Serum Albumin; D004492:Edetic Acid