[Suppression of infarctic changes with mannitol and fluorochemicals--an experimental study].
We have developed and previously reported a canine model for diffuse, incomplete cerebral hemisphere infarction produced by simultaneously occluding the following 5 arteries unilaterally at the base of the brain: the A2 portion of the anterior cerebral artery, the A1 portion of the anterior cerebral artery at the bifurcation of the ethmoidal artery, the internal carotid artery, the posterior cerebral artery at the bifurcation of the posterior communicating artery and the anterior cerebellar artery. After 6 hours of occlusion, recirculation was allowed, and sequential observation was made on the degree of brain swelling. Investigation was made on whether or not administration of 20% mannitol or fluorocarbon emulsion (20% fluosol DA) following vascular occlusion is effective in suppressing such swelling. It was found that brain swelling could be prevented using by mannitol and fluorocarbon emulsion together, but not mannitol and fluorocarbon emulsion alone. Based on these results, we found that mannitol administered together with fluorocarbon emulsion has a protective effect for cerebral infarction following 6 hours vascular occlusion.
D000818:Animals; D001921:Brain / Q000378:metabolism; D002544:Cerebral Infarction / Q000188:drug therapy / Q000473:pathology*; D004285:Dogs; D004338:Drug Combinations / Q000008:administration & dosage / Q000494:pharmacology; D004359:Drug Therapy, Combination; D005466:Fluorocarbons / Q000008:administration & dosage* / Q000494:pharmacology; D006895:Hydroxyethyl Starch Derivatives; D008353:Mannitol / Q000008:administration & dosage* / Q000494:pharmacology; D010101:Oxygen Consumption
D004338:Drug Combinations; D005466:Fluorocarbons; D006895:Hydroxyethyl Starch Derivatives; D008353:Mannitol; C017323:glucose, glycerol, hydroxyethyl starch, perfluorodecalin, perfluorotripropylamine, pluronic F-68, salts, yolk phospholipids drug combination