The oncostatic effect of methyl-CCNU on various experimental lymphoreticular neoplasms.
Studies on the chemotherapeutic potential of methyl-CCNU on experimental leukemias were undertaken. A number of murine transplantable in vivo lines (chemical carcinogen-induced T and B leukemias; radiation- and viral-induced T leukemias of C57BL/6, C3H/eb and SJL/J origin; radiation-induced myeloid leukemias and spontaneous reticulum cell neoplasms of SJL/J mine) were used in these studies. The optimal dose of methyl-CCNU and optimal timing of administration were extensively investigated on two sample lines of T cell leukemias of C57BL/6 mice. Leukemic cell eradication could be achieved in almost all of the different leukemias treated, irrespective of whether induction was brought about by chemical or physical means or due to a viral leukemogenic agent. Studies undertaken to elucidate the effect of methyl-CCNU on the establishment of preleukemic cells following induction of leukemia by the radiation leukemia virus (RadLV) or by total body irradiation, indicated the oncostatic effect of methyl-CCNU on early preleukemic cells.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001772:Blood Cell Count; D001835:Body Weight; D004334:Drug Administration Schedule; D004353:Drug Evaluation, Preclinical; D005260:Female; D006400:Hematocrit; D007942:Leukemia, Experimental / Q000188:drug therapy* / Q000209:etiology; D007953:Leukemia, Radiation-Induced / Q000188:drug therapy; D051379:Mice; D008815:Mice, Inbred Strains; D009607:Nitrosourea Compounds / Q000627:therapeutic use*; D011230:Precancerous Conditions / Q000188:drug therapy* / Q000209:etiology; D012190:Retroviridae; D012673:Semustine / Q000627:therapeutic use*
D009607:Nitrosourea Compounds; D012673:Semustine; D015127:9,10-Dimethyl-1,2-benzanthracene