[Comparative study of the gas transport characteristics of models of an extraerythrocyte oxygen carrier].
It was shown that coupling of the 2,3-DPH functional analog, pyridoxal-5'-phosphate (PP) to hemoglobin (Hb) and its polymer (HbP) enables one to obtain an artificial oxygen carrier with gas transport characteristics similar to those of freshly prepared donor's blood. Coupling of PP to HB and HbP also intensifies their interaction with other physiologically important ligands (H+ and CO2) and changes the pattern of the relationship of P50 to the hemoprotein concentration in a solution.
D001692:Biological Transport; D001802:Blood Substitutes / Q000378:metabolism*; D002245:Carbon Dioxide / Q000097:blood; D004163:Diphosphoglyceric Acids / Q000097:blood; D006454:Hemoglobins / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D008954:Models, Biological; D010100:Oxygen / Q000097:blood*; D011485:Protein Binding / Q000187:drug effects; D011732:Pyridoxal Phosphate / Q000097:blood
D001802:Blood Substitutes; D004163:Diphosphoglyceric Acids; D006454:Hemoglobins; D002245:Carbon Dioxide; D011732:Pyridoxal Phosphate; D010100:Oxygen
Sravnitel'noe izuchenie gazotransportnykh kharakteristik modeleĭ vneéritrotsitarnogo perenoschika kisloroda.