Effect of some membrane stabilizing drugs on histamine-induced contraction of guinea pig ileum.
The effect of disodium cromoglycate (DSCG), pyridoxine and procaine on histamine-induced contraction of isolated guinea pig ileum was investigated. The antiallergic drug DSCG exerted a protective action on ileum against histamine either when it was present or after it was washed out. Procaine, a local anesthetic exerted a similar pharmacological action on ileum to that of DSCG. On the other hand, pyridoxine protected guinea pig ileum against histamine only when it was present in the bath and this effect quickly disappeared after removing of pyridoxine. The mechanism of action of both DSCG and procaine is discussed in relation to their membrane stabilizing effect and inhibition of calcium transport, whereas effect of pyridoxine resembled to some extent, the action of theophylline.
D000818:Animals; D004205:Cromolyn Sodium / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008566:Membranes / Q000187:drug effects; D009119:Muscle Contraction / Q000187:drug effects*; D011343:Procaine / Q000494:pharmacology*; D011736:Pyridoxine / Q000494:pharmacology*
D011343:Procaine; D006632:Histamine; D011736:Pyridoxine; D004205:Cromolyn Sodium