Energy metabolism of the brain in malnutrition. An experimental study in young rhesus monkeys.
An experimental model of protein-calorie malnutrition (PCM) has been successfully produced in young rhesus monkeys. The model showed close resemblance to the energy kinetics of the brain as observed in human PCM inasmuch as oxygen consumption was decreased while glucose uptake was increased. The cerebral blood flow was also diminished. The observations suggest that a significant part of glucose is perhaps diverted to long-chain fatty acids, etc.
D000818:Animals; D001835:Body Weight; D001921:Brain / Q000098:blood supply / Q000378:metabolism*; D002245:Carbon Dioxide / Q000378:metabolism; D004734:Energy Metabolism; D005947:Glucose / Q000378:metabolism; D007773:Lactates / Q000096:biosynthesis; D008253:Macaca mulatta; D010101:Oxygen Consumption; D011502:Protein-Energy Malnutrition / Q000378:metabolism*; D011773:Pyruvates / Q000096:biosynthesis; D012039:Regional Blood Flow
D007773:Lactates; D011773:Pyruvates; D002245:Carbon Dioxide; D005947:Glucose