Caffeine discrimination in the rat.
Rats were trained to discriminate 32 mg/kg caffeine from saline in a two-lever appetitive task. Across a range of caffeine test doses (1-32 mg/kg) rats showed a dose related generalization to the training cue. At intermediate caffeine dose levels, caffeine appeared to produce a more potent cue on tests following saline-training days than after drug-training days. Several psychomotor stimulants (d-amphetamine, methylphenidate, nicotine and TRH) failed to generalize to the caffeine cue. In contrast, theophylline did generalize to caffeine at a dose roughly twice that of the caffeine training dose.
D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology; D005795:Generalization, Stimulus / Q000187:drug effects; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology; D009043:Motor Activity / Q000187:drug effects; D009538:Nicotine / Q000494:pharmacology; D011287:Prejudice / Q000187:drug effects*; D051381:Rats; D013806:Theophylline / Q000494:pharmacology; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology
D008774:Methylphenidate; D002110:Caffeine; D013973:Thyrotropin-Releasing Hormone; D009538:Nicotine; D013806:Theophylline; D003913:Dextroamphetamine