[Metabolic effects of 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) in constant infusion by osmotic minipump to hypothyroid rat (author's transl)].
Our experiments show that the T3 nonhalogenated analog 3,5-dimethyl-3'-isopropyl-L-thyronine (DIMIT) exhibits the general activities of thyroid hormones. DIMIT delivered to hypothyroid Rat by constant infusion or sc injections increases bodyweight gain, BMR before or after epinephrine and phosphorylative oxidation of liver mitochondria.
D000818:Animals; D001481:Basal Metabolism / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D007037:Hypothyroidism / Q000378:metabolism*; D007263:Infusions, Parenteral / Q000295:instrumentation; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013970:Thyronines / Q000008:administration & dosage / Q000494:pharmacology*
D013970:Thyronines; C022861:3,5-dimethyl-3'-isopropyl-L-thyronine
Effets métaboliques de l'administration par minipompe osmotique de la 3,5-diméthyl-3' isopropyl-L-thyronine au rat hypothyroïdien.