[Activation of the antihemophilic globulin A (factor VIII). 2. Effect of ampholine on the course of blood coagulation and the molecular conformation of factor VIII].
Ampholine leads to an increase of activity of factor VIII and in vitro at the same time inhibits the activation of factor XII. The influence on factor XII takes place via influence on the contact surface. All the other coagulation factors remain uninfluenced. There are no differences between normal plasma and plasma of haemophilia with regard to the influence by ampholine. The molecular weight of factor VIII remains uninfluenced by ampholine. The activity of the various molecular forms of factor VIII is increased at the same level by ampholine.
D000665:Ampholyte Mixtures / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D002021:Buffers / Q000494:pharmacology*; D005169:Factor VIII; D005174:Factor XII; D006467:Hemophilia A / Q000097:blood*; D006801:Humans; D008970:Molecular Weight; D011487:Protein Conformation / Q000187:drug effects
D000665:Ampholyte Mixtures; D002021:Buffers; D005169:Factor VIII; D005174:Factor XII
Aktivierung des Antihämophilen Globulin A (Faktor VIII). 2. Einfluss von Ampholine auf den Gesamtablauf der Blutgerinnung und den molekularen Zustand des Faktor VIII.