title: Gentamicin and amikacin disk susceptibility tests with Pseudomonas aeruginosa: definition of minimal inhibitory concentration correlates for susceptible and resistant categories.
abstract: With currently recommended disk susceptibility tests, minimal inhibitory concentration correlates for amikacin were greater than 16 micrograms/ml for resistance and less than or equal to 12 micrograms/ml (not less than or equal to 8 micrograms/ml) for susceptibility. For gentamicin, they were greater than 8 micrograms/ml for resistance and less than or equal to 6 micrograms/ml (not less than or equal to 4 micrograms/ml) for susceptibility. Minor discrepancies between disk tests and minimal inhibitory concentration determinations will occur if only doubling dilutions of drug are used for measuring minimal inhibitory concentration values.
mesh_terms: D000583:Amikacin / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D007612:Kanamycin / Q000031:analogs & derivatives*; D008826:Microbial Sensitivity Tests / Q000379:methods; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000382:microbiology; D011550:Pseudomonas aeruginosa / Q000187:drug effects*
chemical_list: D005839:Gentamicins; D007612:Kanamycin; D000583:Amikacin