title: [Decreased binding by isolated rat hepatocytes of asialo-haptoglobin after combination with hemoglobin].
abstract: The desialilation of 125I-labelled haptoglobin unmasks non-reducing galactose which has become terminal and permits its recognition and binding by isolated hepatocytes. However, the prior formation of an asialohaptoglobin-haemoglobin complex diminishes this property considerably. The explanation suggested is that there could either be a structural rearrangement of the complexed asialo-haptoglobin or steiric hindrance due to a masking of the galactose by the haemoglobin.
mesh_terms: D000818:Animals; D001212:Asialoglycoproteins; D006242:Haptoglobins / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008297:Male; D051381:Rats
chemical_list: D001212:Asialoglycoproteins; D006242:Haptoglobins; D006454:Hemoglobins; C031636:asialohaptoglobin
vernacular_title: Diminution de la captation par l'hépatocyte isolé de rat, de l'asialo-haptoglobine après combinasion avec l'hémoglobine.