Skin window cellularity and macrophage changes in Hodgkin's and non-Hodgkin's lymphomas.
The cutaneous inflammatory response in patients with Hodgkin's and non-Hodgkin's lymphomas was investigated by light and scanning electron microscopy and compared with that of healthy subjects at 24 and 48 h. Both groups of patients showed a reduction in overall cellularity and statistically significant differences in macrophage surface morphology. In macrophages from healthy subjects, microvilli predominated but in lymphoma patients, cells with ruffles and/or ridges (resembling blood monocytes) were more frequent. In healthy subjects, the percentage of macrophages with predominant microvilli increased between day 1 and day 2. It is suggested that both the cellular response and the maturation (or activation) of macrophages are impaired in lymphomas.
D000293:Adolescent; D000328:Adult; D000368:Aged; D006689:Hodgkin Disease / Q000473:pathology*; D006801:Humans; D008223:Lymphoma / Q000473:pathology*; D008264:Macrophages / Q000473:pathology*; D008875:Middle Aged; D012884:Skin Window Technique