title: Electron microscopic cytochemistry of adenylate cyclase in the ovarian compartments of ground squirrel during the annual cycle.
abstract: The ultrastructural localization and the activity changes of adenylate cyclase (AC) were studied in the ovarian compartments of sexually mature ground squirrels (Citellus citellus L.), during the both stages of hibernation (October to December and January to February), after awakening (March) and after gonadotropin (PMSG and HCG) intraperitoneal application during the both above mentioned stages. AC activity was found to be localized on the plasma membranes of theca interna, interstitial, and granulosa cells in ground squirrel ovary. The cytochemical observations presented demonstrate significant AC activity changes in ground squirrel ovary during hibernation, after awakening gonadotrophin treatment and lend support to the concept of AC-cAMP system participation in the gonadotrophin hormone action on the ovary.
mesh_terms: D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D001143:Arousal; D002462:Cell Membrane / Q000201:enzymology / Q000648:ultrastructure; D005260:Female; D006107:Granulosa Cells / Q000201:enzymology / Q000648:ultrastructure; D006605:Hibernation; D008854:Microscopy, Electron; D010053:Ovary / Q000201:enzymology*; D012589:Sciuridae; D012741:Sexual Maturation; D013799:Theca Cells / Q000201:enzymology / Q000648:ultrastructure
chemical_list: D000262:Adenylyl Cyclases