title: The problem of bacillus species infection with special emphasis on the virulence of Bacillus cereus.
abstract: Although Bacillus cereus is an uncommon ocular pathogen, infection with it usually results in loss of the eye. Although previous reports have emphasized endogenous infection, our recent experience indicates the importance of B cereus infection following trauma. Management is hampered by ineffectiveness of current empirical antibiotic regimens. This microorganism is resistant to both the penicillins and the cephalosporins. Although B cereus is susceptible to gentamicin, our studies indicate that gentamicin by itself is inadequate to eradicate the infection. B cereus, however, is susceptible to clindamycin and combined therapy with gentamicin and clindamycin appears to offer the best approach. Early diagnosis is the key to successful treatment. We believe the clinical circumstances likely to lead to B cereus infection, as well as the manifestations of the disease itself, are sufficiently distinctive to alert the ophthalmologist to the possibility of this infection. Prompt recognition of the infection should allow institution of appropriate therapy before permanent structural changes occur.
mesh_terms: D000038:Abscess / Q000209:etiology; D000818:Animals; D001409:Bacillus cereus / Q000472:pathogenicity*; D001424:Bacterial Infections / Q000188:drug therapy*; D002648:Child; D002981:Clindamycin / Q000627:therapeutic use*; D003316:Corneal Diseases / Q000209:etiology; D004359:Drug Therapy, Combination; D005131:Eye Injuries / Q000150:complications; D005839:Gentamicins / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010202:Panophthalmitis / Q000188:drug therapy* / Q000209:etiology; D011817:Rabbits; D014950:Wounds, Penetrating / Q000150:complications
chemical_list: D005839:Gentamicins; D002981:Clindamycin