Further field testing of the more heat-stable measles vaccines in Cameroon.
Two of the more heat-stable measles vaccines were field tested in Cameroon. Both maintained the minimum required infectivity titre and the ability to induce seroconversion after storage unreconstituted at 37 degrees C for 14 days. One of the vaccines, studied after reconstitution, maintained its ability to induce seroconversion after reconstitution and storage at 25 degrees C for 48 hours and at 37 degrees C for at least four hours. The increased heat stability of the studied vaccines will not eliminate the need for a well-monitored system of vaccine conservation and distribution but will ease the rigid cold-storage requirements of conventional measles vaccines.
D000914:Antibodies, Viral / Q000096:biosynthesis; D002163:Cameroon; D004355:Drug Stability; D006385:Hemagglutination Inhibition Tests; D006358:Hot Temperature; D006801:Humans; D007223:Infant; D008457:Measles / Q000276:immunology; D008458:Measles Vaccine / Q000276:immunology / Q000627:therapeutic use*; D013997:Time Factors; D014611:Vaccination
D000914:Antibodies, Viral; D008458:Measles Vaccine