Lack of mature B cells in nude mice with X-linked immune deficiency.
Mice were bred that simultaneously expressed the mutations nude and x-linked immune deficiency (xid). These doubly deficient animals had less than 10% of normal serum immunoglobulin levels. Their spleen cells did not respond to thymus-independent antigens in vitro nor did they respond to lipopolysaccharide. There was a virtual absence of cells with surface mu, kappa, or lambda 1, as detected by fluorescence. Sections of lymphoid organs revealed an absence of primary B cell follicles. Taken together, these results indicate a lack of mature B cells in nude xid mice. The possibility is considered that mature B cells belong to two subpopulations representing two lineages, one controlled by alleles at the xid locus and the other by alleles at the nude locus.
D000361:Agammaglobulinemia / Q000235:genetics / Q000276:immunology*; D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology* / Q000276:immunology; D002454:Cell Differentiation; D005260:Female; D007145:Immunoglobulin kappa-Chains / Q000032:analysis / Q000096:biosynthesis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis / Q000096:biosynthesis; D007958:Leukocyte Count; D008198:Lymph Nodes / Q000473:pathology; D008213:Lymphocyte Activation; D008214:Lymphocytes; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008819:Mice, Nude / Q000235:genetics*; D008934:Mitogens / Q000494:pharmacology; D011947:Receptors, Antigen, B-Cell / Q000032:analysis / Q000096:biosynthesis
D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D008934:Mitogens; D011947:Receptors, Antigen, B-Cell