The effect of multiple rising doses of Ro 11-2465 (serotonin uptake inhibitor) on serotonin content of human platelets.
Ro 11-2465, a cyanide derivative of imipramine with serotonin uptake inhibitory properties, was investigated in six healthy volunteers for its effect on serotonin concentration in blood platelets. The initial dose was 1 mg daily, the maximum dose of 3 mg being reached on day 3 and maintained for 7 days. A significant decrease in the platelet serotonin concentration was not observed until 3 days after the start of drug administration, after which depletion was rapid. After 5 days of treatment, the reduction was about 80% compared to pre-drug level. Serotonin restoration after drug withdrawal was very slow, and 5 days after discontinuation, it was still 70% below its baseline level.
D001792:Blood Platelets / Q000032:analysis* / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007099:Imipramine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D012701:Serotonin / Q000097:blood*; D012702:Serotonin Antagonists / Q000494:pharmacology*
D012702:Serotonin Antagonists; C024316:cianopramine; D012701:Serotonin; D007099:Imipramine