Steady-state lithium blood level fluctuations in man following administration of a lithium carbonate conventional and controlled-release dosage form.
A controlled-release lithium carbonate tablet was compared to an immediate release lithium carbonate capsule in normal volunteers. These crossover studies at steady state showed that the tablet produced a smoother serum curve than the capsule with no loss of total bioavailability. Quantitatively, the capsule produced about 1.4 times more fluctuation in serum lithium values than the tablet.
D000328:Adult; D001682:Biological Availability; D003692:Delayed-Action Preparations; D006801:Humans; D008094:Lithium / Q000008:administration & dosage* / Q000097:blood* / Q000378:metabolism; D016651:Lithium Carbonate
D003692:Delayed-Action Preparations; D016651:Lithium Carbonate; D008094:Lithium