[Inhibition of the diffusion of plasmids by a nitrofuran derivative].
Antibiotic resistance plasmids PR4, R6K, and RGN238 can transfer between Escherichia coli cells by conjugation (transfer frequency: 3 to 3.5 x 10(-4)). Nifurzide, a nitrofuran derivative, greatly depresses plasmid transfer at concentrations (59 microM) which do not affect cell viability.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D003227:Conjugation, Genetic / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects* / Q000235:genetics; D009581:Nitrofurans / Q000494:pharmacology*; D011815:R Factors / Q000187:drug effects*; D013997:Time Factors
D000900:Anti-Bacterial Agents; D009581:Nitrofurans; C029924:nifurzide
Inhibition de la diffusion de plasmides par un dérivé des nitrofuranes.