[Production of histamine and histamine-producing cell stimulating factor (HCSF) by leukocytes incubated with concanavalin A. Effect of presensitization by a skin allograft].
The production of histamine is increased during Con A stimulation of normal spleen cells. This phenomenon results from the action of a factor released by stimulated lymphocytes. The factor is probably HCSF (Histamine-producing Cell Stimulating Factor) that we have previously described in supernatants of mixed lymphocyte culture.
D000818:Animals; D001688:Biological Products; D003208:Concanavalin A / Q000494:pharmacology*; D006632:Histamine / Q000096:biosynthesis / Q000097:blood*; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D016038:Skin Transplantation; D013154:Spleen / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D014184:Transplantation, Homologous
D001688:Biological Products; D003208:Concanavalin A; D006632:Histamine
Production d'histamine et du facteur stimulant des cellules productrices d'histamine (HCSF) par des leucocytes incubés avec la concanavaline A. Effet d'une présensibilisation par une allogreffe de peau.