title: Influence of omega-aminoacids on the activation of the first component of complement at low ionic strength.
abstract: Cl, is the first component of human complement, was activated to Cls by diluting human plasma in a solution of low ionic strength. The addition of lysine and its related aminoacids to plasma resulted in inhibition of Cl activation, alpha, omega-diaminoacids such as lysine and ornithine were most effective and omega-aminoacids such as 6 aminohexanoic acid were far less effective. Tranexamic acid which is most potent in inhibition of fibrinolysis among those aminoacids was least effective in the inhibition of Cl activation. omega-aminoacids or their analogues hardly inhibited Cls which had already been activated.
mesh_terms: D000596:Amino Acids / Q000494:pharmacology*; D015119:Aminocaproic Acid / Q000494:pharmacology; D001120:Arginine / Q000494:pharmacology; D003167:Complement Activation / Q000187:drug effects*; D003172:Complement C1 / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008239:Lysine / Q000494:pharmacology; D009952:Ornithine / Q000494:pharmacology
chemical_list: D000596:Amino Acids; D003172:Complement C1; D001120:Arginine; D009952:Ornithine; D008239:Lysine; D015119:Aminocaproic Acid