[Effect of hypokinesia on bone tumor induction].
The effects of different periods of hypokinesia on the development of 7.12-dimethyl-benzoanthracene-induced osteosarcoma of shinbone were studied in 148 rabbits. The time of induction was found to decrease considerably - from 197.6 to 113.9 days. This may be attributed to hypokinesia's constituting a stress, which involves release of adrenocortical hormones, atrophy of the thymus and reduced cellular immunological vigor.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology; D000818:Animals; D001859:Bone Neoplasms / Q000209:etiology* / Q000473:pathology; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000209:etiology / Q000473:pathology; D012516:Osteosarcoma / Q000209:etiology / Q000473:pathology; D011817:Rabbits; D012149:Restraint, Physical; D013977:Tibia / Q000187:drug effects / Q000473:pathology; D013997:Time Factors
D015127:9,10-Dimethyl-1,2-benzanthracene
Vliianie gipokinezii na induktsiiu opukholeĭ kosteĭ.