Effects of goldthioglucose on hormone secretion of pancreatic rat islets in vitro.
Goldthioglucose enhanced independently of glucose but related to dose the insulin secretion of pancreatic rat islets in vitro. The stimulatory action is additive to that of glucose, is not inhibited by mannoheptulose and not connected with an altered glucose-utilization. The gold thioglucose-induced insulin secretion is diminished in the presence of epinephrine and Mg++, respectively, and characterized by a uniphasic response peaking at 15 min. In the absence of glucose goldthioglucose did not modify the pancreatic glucagon secretion.
D000818:Animals; D006051:Aurothioglucose / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D005947:Glucose / Q000494:pharmacology; D006046:Gold / Q000494:pharmacology*; D066298:In Vitro Techniques; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008274:Magnesium / Q000494:pharmacology; D051381:Rats
D007328:Insulin; D006051:Aurothioglucose; D006046:Gold; D008274:Magnesium; D005947:Glucose; D004837:Epinephrine