Synthesis of phenylphenoxyacetamide derivatives with potential antiinflammatory activity.
Twenty four derivatives of N-(phenoxyacetyl)-p-aminophenoxyacetic acid have been obtained. The tests of the in vitro inhibition of prostaglandin synthetase revealed that compounds 19 and 24 have the activity similar to that of Naproxen.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D002417:Cattle; D002626:Chemistry, Pharmaceutical / Q000379:methods; D016861:Cyclooxygenase Inhibitors; D004353:Drug Evaluation, Preclinical; D006016:Glycolates / Q000138:chemical synthesis*; D008297:Male; D008861:Microsomes / Q000201:enzymology; D010642:Phenoxyacetates / Q000138:chemical synthesis*; D012669:Seminal Vesicles / Q000648:ultrastructure
D000893:Anti-Inflammatory Agents; D016861:Cyclooxygenase Inhibitors; D006016:Glycolates; D010642:Phenoxyacetates; C030293:N-(phenoxyacetyl)-4-aminophenoxyacetic acid