Vincristine inhibits the synthesis of malondialdehyde by human platelets in vitro.
When platelet-rich plasma was preincubated with vincristine, a depression in malondialdehyde production was seen when compared with saline controls. Colchicine caused an increase in malondialdehyde production. If prostaglandins are important in tumor-cell metabolism, then vincristine might exert some of its cytotoxic effect by depressing prostaglandin production.
D000328:Adult; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D003078:Colchicine / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008314:Malonates / Q000096:biosynthesis*; D008315:Malondialdehyde / Q000032:analysis / Q000096:biosynthesis*; D010974:Platelet Aggregation / Q000187:drug effects; D011460:Prostaglandins F / Q000032:analysis / Q000096:biosynthesis; D013917:Thrombin / Q000494:pharmacology; D014750:Vincristine / Q000494:pharmacology*
D001095:Arachidonic Acids; D008314:Malonates; D011460:Prostaglandins F; D016718:Arachidonic Acid; D008315:Malondialdehyde; D014750:Vincristine; D013917:Thrombin; D003078:Colchicine