Immunological characterization of hemopoietic cells in the common marmoset, rhesus monkey, and man. In search of a model for human marrow transplantation.
Bone marrow, lymphoid, and peripheral blood cells from the common marmoset and rhesus monkey have been tested with a panel of heterologous and monoclonal antibodies, and their reactivity pattern has been compared with that of blood and bone marrow cells from human donors. Conventional antibodies reveal extensive cross-reactivity within the B cell, T cell, and granulocytic systems in all three species, however, some important differences have been exposed. Only the monoclonal antibodies to HLA-A,B,C and Ia-like antigens react with marmoset cells, and we have exploited this finding to show that the vast majority of colony-forming units (CFU-c) in the marmoset bone marrow (as in man) are Ia positive. The use of the common marmoset as a suitable model for human bone marrow transplantation is discussed in the light of these findings.
D000818:Animals; D000906:Antibodies / Q000276:immunology; D001402:B-Lymphocytes / Q000032:analysis; D016026:Bone Marrow Transplantation; D002143:Callitrichinae / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D008251:Macaca / Q000276:immunology*; D008253:Macaca mulatta / Q000276:immunology*; D008954:Models, Biological; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000032:analysis; D013950:Thymus Gland / Q000166:cytology
D000906:Antibodies; D007106:Immune Sera