[Role of pH in the mechanism of action of CO2 on the smooth musculature of cerebral arteries].
It has been discovered on isolated strips of the internal carotid artery of man that changes in extracellular pH influence the effects of hypercapnia that manifest in relaxation of smooth muscles. However, under conditions of pH stabilization within the range of 7.3--7.4 the direct action of hypercapnia was unchanged. Acetazolamide, the blocker of the intracellular carboanhydrase activity, inhibited the effects of hypercapnia. It is inferred that changes in the intracellular H+ are of the greatest importance in the action mode of CO2 on smooth muscles of the vessels, whereas changes in the extracellular pH have but a modulating effect.
D000086:Acetazolamide / Q000494:pharmacology; D000818:Animals; D002245:Carbon Dioxide / Q000494:pharmacology*; D002339:Carotid Arteries / Q000187:drug effects*; D002343:Carotid Artery, Internal; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*
D002245:Carbon Dioxide; D000086:Acetazolamide
Rol' pH v mekhanizme deĭstviia CO2 in gladkuiu muskulaturu arteriĭ golovnogo mozga.