title: Microbial transformations of 7,2-dimethylbenz[a]anthracene.
abstract: Microbial transformations of 7,12-dimethylbenz[a]anthracene, a carcinogenic polycyclic aromatic hydrocarbon, in cultures of Pseudomonas aeruginosa and Penicillium notatum were studied by high performance liquid chromatographic separation of metabolic fractions followed by gas chromatographic-mass spectrometric analysis of the metabolites. Two methyl-hydroxylated metabolites were identified in each of the incubations. The metabolic activation of the polycyclic aromatic hydrocarbon suggests a possible involvement of microorganisms in environmental carcinogenesis.
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000378:metabolism*; D001551:Benz(a)Anthracenes / Q000378:metabolism*; D001711:Biotransformation; D010407:Penicillium / Q000378:metabolism*; D011550:Pseudomonas aeruginosa / Q000378:metabolism*
chemical_list: D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene