6-hydroxydopamine in the treatment of open-angle glaucoma.
We evaluated the effectiveness of subconjunctival injections of 6-hydroxydopamine in conjunction with epinephrine in lowering ocular tension in 63 eyes of 61 patients with open-angle glaucoma. A single injection caused a peak median reduction in ocular tension of 6 mm Hg four weeks after the injection. Ten eyes (16%) showed no significant decrease in ocular tension. A single injection significantly decreased the ocular tension for 12 weeks in 40 (63%) and for 20 weeks in 21 (33%) of the eyes. The fellow control eyes showed a slight but not significant decrease in ocular tension.
D000328:Adult; D000368:Aged; D003228:Conjunctiva; D004359:Drug Therapy, Combination; D004837:Epinephrine / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D006892:Hydroxydopamines / Q000494:pharmacology / Q000627:therapeutic use*; D007267:Injections; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D016627:Oxidopamine
D006892:Hydroxydopamines; D016627:Oxidopamine; D004837:Epinephrine