[Effect of synthetic polyelectrolytes on T- and B-cell cooperation after immunization of different genotype mice with artificial antigen (T, G)-A-L].
Interstrain differences in the primary immune response to the synthetic polypeptide (T,G)-A-L were disclosed at the level of IgM plaque-forming cells in the adoptive transfer system. Immunization of low responder mice with poly-4-vinylpyridine or polyacrylic acid in conjunction with bone marrow and thymus cells enhanced the immune response up the level of high responders, manifesting in anti-(T,G)-A-L immune response phenotypic correction. These data obtained for the first time denote the possibility of a specific Ir-gene-controlled immune response to be corrected by synthetic polyelectrolytes.
D000180:Acrylic Resins / Q000494:pharmacology*; D000818:Animals; D005802:Genes, MHC Class II; D006824:Hybridization, Genetic; D008211:Lymphocyte Cooperation / Q000187:drug effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010455:Peptides / Q000276:immunology*; D011145:Polyvinyls / Q000494:pharmacology*; D011725:Pyridines / Q000494:pharmacology*
D000180:Acrylic Resins; D010455:Peptides; D011145:Polyvinyls; D011725:Pyridines; C018606:2-methyl-5-vinylpyridine polymer; C021759:(T,G)-A-L; C006903:carbopol 940
Vliianie sinteticheskikh poliélektrolitov na kooperatsiiu T- i B-kletok pri immunizatsii mysheĭ raznykh genotipov iskusstvennym antigenom (T, G)-A-L.