Waldenström-like lymphoma with monoclonal IgG1-kappa: evidence of common clonal origin.
A patient with a pleomorphic lymphoplasmacytic bone marrow infiltration, a peripheral lymphocytosis and a monoclonal IgG1-kappa gammopathy is described. An antiidiotype serum, raised against the monoclonal serum protein showed a common clonal origin of the pleomorphic cell population. In the light of recent report on B-cell neoplasms associated with M-components, a hypothetical scheme of the cellular clonal event is proposed.
D000368:Aged; D001402:B-Lymphocytes / Q000276:immunology; D001853:Bone Marrow / Q000276:immunology; D003593:Cytoplasm / Q000276:immunology; D005455:Fluorescent Antibody Technique; D006801:Humans; D006942:Hypergammaglobulinemia / Q000276:immunology*; D007106:Immune Sera; D007074:Immunoglobulin G / Q000032:analysis*; D007130:Immunoglobulin Idiotypes / Q000276:immunology; D007147:Immunoglobulin Light Chains / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008954:Models, Biological; D011947:Receptors, Antigen, B-Cell / Q000032:analysis; D008258:Waldenstrom Macroglobulinemia / Q000276:immunology*
D007106:Immune Sera; D007074:Immunoglobulin G; D007130:Immunoglobulin Idiotypes; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D007136:Immunoglobulins; D011947:Receptors, Antigen, B-Cell