[Intestinal response to glucose in experimental cholera in malnourished, adult and growing rats (author's transl)]].
We examined the influence of malnutrition on intestinal response to glucose in experimental cholera. Water, electrolytes, and glucose fluxes were directly measured, in isolated ligated loops of rat jejunum. Intestinal loops were filled with Ringer added with either mannitol (30 mM), glucose (30 mM), cholera toxin (TC), or a combination of these three components. The results are as follows: 1. Malnutrition has an effect on basal absorption rate, intestinal response to TC and also to glucose. 2. The secretory effect of cholera toxin is altered by the type of malnutrition, the animal's age and the presence of cholera toxin. 3-0 methyl-glucose, a non-metabolised glucose analogue, has essentially the effect of glucose. The effects produced on water fluxes are also found for Na, K, Cl, HCO3 and glucose fluxes. The relationships between water, glucose, and Na fluxes are not influenced by the different experimental conditions. These results indicate that the intestinal response to glucose in experimental cholera is strongly dependent on the type of malnutrition, the animal's age and the presence of cholera toxin.
D000375:Aging; D000818:Animals; D002771:Cholera / Q000378:metabolism*; D004573:Electrolytes / Q000494:pharmacology; D005947:Glucose / Q000378:metabolism / Q000494:pharmacology*; D007408:Intestinal Absorption / Q000187:drug effects*; D011502:Protein-Energy Malnutrition / Q000378:metabolism*; D051381:Rats
D004573:Electrolytes; D005947:Glucose
La réponse intestinale au glucose dans le choléra expérimental du rat malnutri, adulte et en croissance.