[Ultrastructure of female rat FSH gonadotrophs following two LH-RH stimulations (author's transl)].
In FSH-cells of female rats increased granule extrusion and increased granule synthesis was observed using electron-microscopy 60 min and 60--120 min, respectively, after a single 250 microgram LH-RH injection. Granule content was distinct higher 120 min after LH-RH when compared with NaCl treated animals. These "excessively" synthesized granules were subsequently removed by increased cytolysosomal degradation. When a second LH-RH injection of the same dose was given 120 min. after the first, a distinct augmentation of granule extrusion, -synthesis and -degradation was observed indeed in the same time-sequence as observed after the first LH-RH stimulation. As reported previously for LH, also FSH is secreted from FSH gonadotrophs by in toto granule extrusion. Subsequently the granule content was immediately restored by intracellular regulatory processes.
D000818:Animals; D003594:Cytoplasmic Granules / Q000187:drug effects* / Q000648:ultrastructure; D005260:Female; D005640:Follicle Stimulating Hormone / Q000096:biosynthesis / Q000378:metabolism; D007987:Gonadotropin-Releasing Hormone; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism / Q000648:ultrastructure; D051381:Rats; D013997:Time Factors
D007987:Gonadotropin-Releasing Hormone; D005640:Follicle Stimulating Hormone
Ultrastruktur der FSH-Zelle der weiblichen Ratte nach zweimaliger LH-RH-Stimulation.