Bone mass in obese, goldthioglucose-treated, hyperglycaemic mice.
In contrast to insulin-dependent diabetics, bone mass in obese non-insulin dependent diabetics seems to be greater than in normal subjects. Hyperglycaemic, obese goldthioglucose mice were studied as a model for this last type of diabetes. A significantly greater cortical bone mass (cortical surface: 1.32 mm2 vs 1.15 mm2 for controls, p less than 0.01) with enhanced bone apposition was found together with a significantly greater trabecular bone mass (trabecular surface 0.17 mm2 vs 0.13 mm2, p = 0.05) increasing bone solidity. The pathogenesis is unclear but hyperinsulinism and overnutrition may be contributory factors.
D000818:Animals; D006051:Aurothioglucose / Q000494:pharmacology*; D001842:Bone and Bones / Q000033:anatomy & histology / Q000187:drug effects / Q000503:physiopathology*; D005260:Female; D006046:Gold / Q000494:pharmacology*; D006943:Hyperglycemia / Q000503:physiopathology*; D051379:Mice; D009765:Obesity / Q000503:physiopathology*
D006051:Aurothioglucose; D006046:Gold