title: Assessment of optimal L-thyroxine replacement dose by the TRH test.
abstract: Two hundred patients taking varying L-thyroxine replacement doses were studied using a normal TRH test as the index of optimal replacement dose. The mean optimal dose was 141 microgram/day. Normal serum T3 and FT3I were found in most patients, whatever the TRH response, and they are probably too unspecific. Serum T4 and FT4I were elevated in many patients with a normal TRH response. A higher range for FT4I of 102-166, although only 66.5% accurate, gave the best index of optimal L-thyroxine replacement of the single in-vitro tests.
mesh_terms: D000918:Antibody Specificity; D006801:Humans; D007037:Hypothyroidism / Q000188:drug therapy; D011863:Radioimmunoassay; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000008:administration & dosage* / Q000627:therapeutic use; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine