title: Intestinal and hepatic morphine glucuronidation in immature and pregnant rats.
abstract: The glucuronyl transferase activity was measured in the rat liver and intestinal microsomes during the neonatal development and pregnancy using 14C-morphine as substrate. During development the hepatic glucuronyl transferase activity increased 16-fold from day 1 after birth until a maximum of 9.97 nmol/min/mg on day 20. The enzyme activity in intestinal microsomes increased only 4-fold from day 1 to 0.19 nmol/min/mg on day 30. After the peak activities were reached, there was a continuous decrease in the glucuronyl transferase activities. During pregnancy the glucuronyl transferase activity increased significantly in the liver while no change was observed in the intestinal microsomal fraction.
mesh_terms: D000375:Aging; D000818:Animals; D005260:Female; D005965:Glucuronates / Q000378:metabolism; D014453:Glucuronosyltransferase / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism; D009020:Morphine / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D005965:Glucuronates; D009020:Morphine; D014453:Glucuronosyltransferase