Resistance to fluorouracil in Candida utilis: effects on the uptake of pyrimidines and amino acids.
5-Fluorouracil powerfully inhibits growth of Candida utilis. Isolates that are resistant to fluorouracil all have a reduced ability to transport uracil but most also have other defects. Their capacity to take up a wide range of amino acids is greatly reduced, as is their ability to alter rates of amino acid transport during nitrogen starvation. These isolates may be defective in the coupling of energy generation to transport systems.
D000596:Amino Acids / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D002175:Candida / Q000187:drug effects* / Q000378:metabolism; D004352:Drug Resistance, Microbial; D005472:Fluorouracil / Q000494:pharmacology*; D008239:Lysine / Q000378:metabolism; D009584:Nitrogen / Q000378:metabolism; D014498:Uracil / Q000378:metabolism*
D000596:Amino Acids; D014498:Uracil; D008239:Lysine; D009584:Nitrogen; D005472:Fluorouracil