Dose-dependent pharmacokinetics of PMM in the rat.
Concentrations of pentamethylmelamine (PMM) and some metabolites were determined in plasma of rats treated with 10 and 50 mg PMM/kg IV. The areas under the plasma levels curve after these doses were 241 and 1,827 mu g/ml X min; plasma clearances were 0.042 and 0.027 l . kg(-1) . min(-1), respectively. These data suggest that PMM pharmacokinetics is dose-dependent in the rat. The N-demethylated metabolite levels were not proportional to the administered dose.
D006585:Altretamine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D007700:Kinetics; D008297:Male; D051381:Rats; D014227:Triazines / Q000378:metabolism*
D014227:Triazines; D006585:Altretamine; C022048:pentamethylmelamine