Reserpine prevents goldthioglucose hypothalamic lesions in mice.
In reserpinized mice the occurrence of goldthioglucose hypothalamic lesions was significantly lower than in control mice. Some protection was also conferred by serotonin-receptor blockers and by treatment with nialamide + DL-alpha-methyldopa, but the protective effect of reserpine was not reversed by serotonergic and dopaminergic agonists, alone or in combination, nor by insulin.
D000818:Animals; D006051:Aurothioglucose / Q000494:pharmacology*; D002928:Cinanserin / Q000031:analogs & derivatives / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006046:Gold / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects*; D007033:Hypothalamus, Middle / Q000187:drug effects*; D008719:Methiothepin / Q000494:pharmacology; D008750:Methyldopa / Q000494:pharmacology; D051379:Mice; D009526:Nialamide / Q000494:pharmacology; D012110:Reserpine / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology
D012702:Serotonin Antagonists; C011607:SQ 10631; D006051:Aurothioglucose; D008719:Methiothepin; D008750:Methyldopa; D006046:Gold; D012110:Reserpine; D002928:Cinanserin; D009526:Nialamide