[Effect of diacarb on the carbonic anhydrase activity in the blood and gastric mucosa and pepsinogen concentration in the gastric mucosa of the rat].
It was established that the activity of blood and gastric mucosa carboanhydrase increased after the introduction of food irritant (milk) into the stomach, as well as after the subcutaneous injection of histamine. This was accompanied by the increase of pepsinogen content in the gastric mucosa. When introduced into the stomach before the food irritant or histamine, acetazolamide inhibited blood and gastric mucosa carboanhydrase and reduced the content of pepsinogen in the gastric mucosa. Oral administration of acetazolamide for 5 days resulted in a more remarkable inhibition of blood and gastric mucosa carboanhydrase and in a drastically reduced content of pepsinogen in the gastric mucosa. The rate of pepsinogen biosynthesis by the gastric mucosa seems to depend on the activity of carboanhydrase in blood and in the gastric mucosa.
D000086:Acetazolamide / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002256:Carbonic Anhydrases / Q000097:blood / Q000378:metabolism*; D004032:Diet; D005753:Gastric Mucosa / Q000378:metabolism*; D006632:Histamine / Q000008:administration & dosage; D008297:Male; D008892:Milk; D010435:Pepsinogens / Q000032:analysis*
D010435:Pepsinogens; D006632:Histamine; D002256:Carbonic Anhydrases; D000086:Acetazolamide
Vliianie diakarba na aktivnost' karbonangidrazy v krovi i slizistoĭ obolochke zheludka i na soderzhanie pepsinogena v slizistoĭ zheludka krys.