title: Threonine as a carbon source for Escherichia coli.
abstract: Threonine can be used aerobically as the sole source of carbon and energy by mutants of Escherichia coli K-12. The pathway used involves the conversion of threonine via threonine dehydrogenase to aminoketobutyric acid, which is further metabolized by aminoketobutyric acid ligase, forming acetyl coenzyme A and glycine. A strain devoid of serine transhydroxymethylase uses this pathway and excretes glycine as a waste product. Aminoketobutyric acid ligase activity was demonstrated after passage of crude extracts through Sephadex G100.
mesh_terms: D000085:Acetates / Q000378:metabolism; D000105:Acetyl Coenzyme A / Q000378:metabolism; D000123:Acetyltransferases / Q000378:metabolism; D000332:Aerobiosis; D004926:Escherichia coli / Q000378:metabolism*; D005998:Glycine / Q000378:metabolism; D013912:Threonine / Q000378:metabolism*
chemical_list: D000085:Acetates; D013912:Threonine; D000105:Acetyl Coenzyme A; D000123:Acetyltransferases; C020679:glycine acetyltransferase; D005998:Glycine