title: Influence of low doses of naloxone on pituitary secretion in man.
abstract: Naloxone 0.8 mg im administered to eight healthy subjects did not affect the serum levels of GH, LH, FSH, PRL, TSH and cortisol. Pretreatment with naloxone 0.8 mg increased TRH-induced TSH and PRL release in six healthy subjects. The same pretreatment caused an enhancement of haloperidol-induced PRL secretion in further other group of six subjects.
mesh_terms: D000328:Adult; D005260:Female; D006220:Haloperidol / Q000494:pharmacology; D006801:Humans; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D010902:Pituitary Gland / Q000187:drug effects* / Q000378:metabolism; D010907:Pituitary Hormones / Q000097:blood; D011388:Prolactin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology; D013997:Time Factors
chemical_list: D010907:Pituitary Hormones; D009270:Naloxone; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D006220:Haloperidol