Determination of serum galactosyltransferase levels in ovarian cancer patients for the evaluation of the effectiveness of therapeutic programs.
The activity of galactosyltransferase using endogenous acceptor(s), (GT-En) in the sera of ovarian cancer patients was significantly higher than age and blood-group matched controls. GT-En, and galactosyltransferase activity using an exogenous acceptor (GT-Ex), were assayed in the sera of 30 patients undergoing treatment for ovarian epithelial cancer, at the start of chemotherapy, and after a suitable interval. The direction of the alterations in levels of both these enzymes correctly reflected the clinical response to chemotherapy in most of these patients. The assay of GT-En and GT-Ex in the serum may be useful for the evaluation of the effectiveness of therapeutic programs in these patients.
D005260:Female; D005700:Galactosyltransferases / Q000097:blood*; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000201:enzymology*
D006023:Glycoproteins; D005700:Galactosyltransferases