Dialysis and renal transplant in a hemophiliac.
Hemodialysis was initiated in a mild-moderate hemophiliac at 15 years of age. Hematuria had been a frequent and persisting feature from the age of five years without documented cause. Anemia and proteinuria was first detected at 13 years. A cadaver donor renal transplant was carried out after three months of hemodialysis. Massive intravesical bleeding complicated the immediate post-transplantation period. The allograft rejected after three months and the patient was maintained for eight years on home hemodialysis. A second cadaver donor allograft was carried out at 23 years of age. Again, massive intravesical hemorrhage was a problem post-transplant. The allograft is currently functioning 27 months post-transplant. Factor VIIIc activities have fluctuated between 5% and 40% in the absence of factor infusions.
D000293:Adolescent; D000328:Adult; D002648:Child; D005169:Factor VIII / Q000032:analysis; D005500:Follow-Up Studies; D006084:Graft Rejection; D006417:Hematuria / Q000209:etiology; D006467:Hemophilia A / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007676:Kidney Failure, Chronic / Q000175:diagnosis / Q000628:therapy*; D016030:Kidney Transplantation; D008297:Male; D011183:Postoperative Complications / Q000209:etiology; D006435:Renal Dialysis
D005169:Factor VIII