Antihypertensive effect of plasma volume expansion in pregnancy-associated hypertension.
Plasma and total extracellular fluid volume expansion was confirmed in normal pregnant women in the third trimester of pregnancy. The plasma volume contraction of pregnancy-associated hypertension (pre-eclampsia) was found to be associated with an increase in the interstitial compartment of extracellular fluid volume. The infusion of a plasma volume expander produced significant amelioration of hypertension for 48 h associated with partial reversal of the disturbance of fluid distribution. This finding confirms the central place of volume contraction in maintenance of elevated blood pressure in pregnancy-associated hypertension.
D000328:Adult; D005110:Extracellular Space / Q000032:analysis; D005260:Female; D006801:Humans; D006973:Hypertension / Q000628:therapy*; D008353:Mannitol / Q000097:blood; D008433:Mathematics; D010952:Plasma Substitutes / Q000627:therapeutic use*; D010953:Plasma Volume; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000628:therapy*
D010952:Plasma Substitutes; D008353:Mannitol