Direct ADCC lysis of O,Rh-positive (R1R2) erythrocytes by lymphocytes of individuals sensitized against antigen D.
Non-T-cells from individuals sensitized against antigen D were found to lyze O,Rh-positive erythrocytes. The lytic effect was abolished by incubation of the effector cells at 37 degrees C for 30 min, and was reconstituted by addition of anti-D antibodies. These results suggested that sensitized donors have lymphocytes armed with specific antibodies in vivo.
D000017:ABO Blood-Group System / Q000276:immunology*; D000920:Antibody-Dependent Cell Cytotoxicity; D006801:Humans; D007114:Immunization; D007518:Isoantibodies / Q000096:biosynthesis*; D007694:Killer Cells, Natural / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D012397:Rosette Formation
D000017:ABO Blood-Group System; D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System