Hypercalcemia influences TRH-stimulated TSH and T3 response.
The influence of acute hypercalcemia induced by i.v. infusion of calcium gluconate on basal TSH and T3 levels in plasma and on their response to TRH stimulation (TRH test) was investigated in 10 healthy subjects. TRH test under normal conditions without hypercalcemia was carried out in the same subjects. Under acute hypercalcemia the basal T3 levels were evaluated markedly up to levels occurring after TRH stimulation. However, the relative increase of T3 following TRH challenge was of the same degree as in normocalcemia. Basal TSH levels did not differ from those found under normocalcemia, but the response to TRH was decreased. The results suggest that hypercalcemia affects the mechanisms regulating the levels of the thyroid hormones and TSH.
D000328:Adult; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000097:blood*; D008875:Middle Aged; D013972:Thyrotropin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone; D014284:Triiodothyronine / Q000097:blood*
D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D002118:Calcium