Murine interstitial nephritis. I. Analysis of disease susceptibility and its relationship of pleiomorphic gene products defining both immune-response genes and a restrictive requirement for cytotoxic T cells at H-2K.
Anti-tubular basement membrance (alpha TBM) disease-producing interstitial nephritis in mice is not dependent on the generation of alpha TBM antibodies. Susceptibility seems to be defined by very private specificities in H-2K. These specificities are pleiomorphic, providing both immune-response genes and identity restrictions for cytotoxic effector functions expressed by a Thy-1.2+, Lyt-2,3+ T cell. These studies establish a role for T cells in the pathogenesis in interstitial nephritis as well as providing further evidence for the role of H-2K in the expression of an autoimmune disease.
D000818:Animals; D001485:Basement Membrane / Q000276:immunology; D001666:Binding Sites, Antibody; D001806:Blood Urea Nitrogen; D003602:Cytotoxicity, Immunologic; D004198:Disease Susceptibility; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics*; D007684:Kidney Tubules / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008805:Mice, Inbred A; D008806:Mice, Inbred AKR; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D009395:Nephritis, Interstitial / Q000235:genetics* / Q000276:immunology; D014176:Protein Biosynthesis; D011817:Rabbits; D013601:T-Lymphocytes / Q000276:immunology
D006183:H-2 Antigens