In vivo and in vitro effects of endotoxin on prostaglandin release from rat lung.
1 The release of prostaglandins (PGE2, PGF2 alpha, PGI2) and thromboxane A2 (TxA2) from rat lung exposed to E. coli endotoxin, in vivo or in vitro has been studied. 2 Lung strips of endotoxin-treated rats demonstrated a preferential increase of TxA2 and PGF2 alpha and a decrease in the ratio PGI2/TxA2. 3 These data suggest that changes in the proportions of arachidonic acid metabolites might play a role in the pulmonary pathophysiology during endotoxin shock. 4 Incubation of lung strips with endotoxin in vitro failed to stimulate prostaglandin release; paradoxically, it suppressed both the spontaneous and the ionophore-induced prostaglandin release. 5 These findings suggest that the increase in prostaglandin release by the lung following endotoxin administration in vivo is probably mediated by factor(s) generated in endotoxaemia and is not due to a direct action of endotoxin on the lung tissue.
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D004731:Endotoxins / Q000494:pharmacology*; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D013928:Thromboxane A2 / Q000378:metabolism
D004731:Endotoxins; D011453:Prostaglandins; D000001:Calcimycin; D013928:Thromboxane A2