Ethamsylate in the treatment of climacteric flushing.
Ethamsylate, a non-hormonal agent acting at the capillary level, was compared with a placebo in a double-blind trial of 12 wk duration in 20 post-menopausal patients with hot flushes. Both ethamsylate and placebo patients showed fluctuations in the frequency of flushes during the trial, but there was a significant downward trend in the ethamsylate group. Capillary strength was measured but was not found to be low or to alter during the trial except in 1 patient in the placebo group. No side-effects attributable to trial medication were reported. Other symptoms recorded during the trial were probably climacteric and occurred more frequently during placebo treatment than during treatment with ethamsylate.
D000328:Adult; D001557:Benzenesulfonates / Q000627:therapeutic use*; D002979:Climacteric / Q000187:drug effects*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004967:Estrogens / Q000097:blood; D004979:Ethamsylate / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006801:Humans; D007494:Ireland; D008875:Middle Aged; D010865:Pilot Projects; D011863:Radioimmunoassay
D001557:Benzenesulfonates; D004967:Estrogens; D004979:Ethamsylate; D005640:Follicle Stimulating Hormone