[Role of female genotype in manifestation of dominant lethal mutations induced by thiophosphamide in the spermatids of male rats].
Hybrid male mice FICD2 were injected intraperitoneally with thioTEPA at a dose of 1.5 mg/kg or 2.0 mg/kg. During the second week after the treatment males were mated with females of 101/HY, C57BL/6JY and CBA/LacY strains, and embryoic mortality was studied on 3.5 day of pregnancy cytologically and on 15-17 days -- by the dominant lethal method. ThioTEPA did not affect the rate of fertilization. The dominant lethals frequencies differed significantly in females 101 (67%), B6 (59%) and CBA (43%). It is suggested that the differences observed are due to different activity of repair systems in oocytes of females of these strains.
D000818:Animals; D005260:Female; D005306:Fertilization / Q000187:drug effects; D005313:Fetal Death; D005799:Genes, Dominant; D005804:Genes, Lethal; D005838:Genotype; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D009154:Mutation; D011247:Pregnancy; D012737:Sex Factors; D013045:Species Specificity; D013087:Spermatids / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*; D013852:Thiotepa / Q000494:pharmacology*
D013852:Thiotepa
Rol' genotipa samok v proiavlenii dominantnykh letal'nykh mutatsiĭ, indutsirovannykh tiofosfamidom v spermatidakh samtsov mysheĭ.