Colonization of the oropharynx with Gram-negative bacilli in children with severe protein-calorie malnutrition.
Oral pharyngeal isolation of Gram-negative bacteria was compared in four groups of Bengali children; acutely ill, severely malnourished outpatients swabbed on hospital admission; ill but less severely malnourished outpatients from the same area as the malnourished children; orphans also less severely malnourished but not acutely ill; and well controls drawn from a priviledged socioeconomic group. The expected weight for height percentage (National Center Health Statistics/Center for Disease Control median) of the four groups was respectively 67, 91, 97, and 97%. Isolation of Gram-negative bacteria from 74 of 87 (85%) severely malnourished children was significantly greater (p less than 0.01) compared to 43 of 113 (38%) outpatients, to 20 of 93 (22%) orphans, and to five of 51 (10%) controls. A total of 71 malnourished children under 5 yr of age (90%) had higher rates of Gram-negative throat colonization than did 16 older children (63%) (p less than 0.01). Thus there was an increased rate of Gram-negative colonization in severely malnourished children especially among the younger age group. In the subset of ill children, Gram-negative pharyngeal colonization was significantly associated inversely with nutritional indices and age. The high rate of such carriage may be partly responsible for the increased susceptibility of Gram-negative infection demonstrated in these children.
D001827:Body Height; D001835:Body Weight; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility; D005260:Female; D006088:Gram-Negative Aerobic Bacteria / Q000032:analysis*; D006089:Gram-Negative Anaerobic Bacteria / Q000032:analysis*; D006400:Hematocrit; D006801:Humans; D007223:Infant; D008297:Male; D009960:Oropharynx / Q000382:microbiology*; D011502:Protein-Energy Malnutrition / Q000382:microbiology*