Serum glycosidase activity in diabetes mellitus.
The activity of three glycosidic enzymes, B-glucuronidase, N-acetylglucosaminidase, and B-galactosidase were measured in plasma samples from 163 diabetic subjects and 72 normal controls. No age- or sex-based variation in concentration was noted in controls. Plasma activity of B-glucuronidase and N-acetylglucosaminidase in diabetics correlated directly with the overall level of glycemia as measured by HbA1c levels. B-galactosidase activity was consistently normal in diabetics. A significant age-based variation was noted in the diabetic group for B-glucuronidase and N-acetylglucosaminidase. Prior to age 12 B-glucuronidase and N-acetylglucosaminidase were normal in diabetics, but activity increased significantly after the age of 12, a change that appeared to coincide with the development of puberty.
D000118:Acetylglucosaminidase / Q000097:blood*; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D002648:Child; D003920:Diabetes Mellitus / Q000201:enzymology*; D005260:Female; D005696:Galactosidases / Q000097:blood*; D005966:Glucuronidase / Q000097:blood*; D006027:Glycosides / Q000032:analysis; D006441:Hemoglobin A / Q000031:analogs & derivatives / Q000032:analysis; D006596:Hexosaminidases / Q000097:blood*; D006801:Humans; D006943:Hyperglycemia / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D011627:Puberty; D001616:beta-Galactosidase / Q000097:blood*
D006027:Glycosides; D006441:Hemoglobin A; D005696:Galactosidases; D006596:Hexosaminidases; D001616:beta-Galactosidase; D005966:Glucuronidase; D000118:Acetylglucosaminidase