title: Corticoliberin and somatoliberin activity in the pituitary stalk median eminence of rats after neonatal treatment with monosodium glutamate.
abstract: Neurotoxic lesions of the arcuate nucleus by neonatal treatment monosodium glutamate (MSG) resulted in a decrease of plasma GH levels without affecting plasma corticosterone concentration. The corticoliberin activity of the pituitary stalk median eminence (SME) in MSG-treated animals was similar to that of litter-mate controls. Growth hormone releasing (somatoliberin) activity of the SME, tested after placing an anterolateral cut around the medial basal hypothalamus, was significantly lower in MSG- treated than in control animals. It was concluded that the substantial proportion of the somatoliberin neurones are found in the arcuate nucleus.
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D003345:Corticosterone / Q000097:blood; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D005260:Female; D005971:Glutamates / Q000494:pharmacology*; D013006:Growth Hormone / Q000097:blood; D013007:Growth Hormone-Releasing Hormone / Q000378:metabolism*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects*; D008297:Male; D008473:Median Eminence / Q000187:drug effects* / Q000378:metabolism; D008526:Medulla Oblongata / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D012970:Sodium Glutamate / Q000494:pharmacology*
chemical_list: D005971:Glutamates; D013006:Growth Hormone; D003346:Corticotropin-Releasing Hormone; D013007:Growth Hormone-Releasing Hormone; D012970:Sodium Glutamate; D003345:Corticosterone