Recirculation in the acute period of cerebral infarction: brain swelling and its suppression using mannitol.
Using the incomplete cerebral hemisphere infarction model in dogs, observations were made on the effect of 20% mannitol on brain swelling in groups of experimental animals following recirculation. In dogs undergoing 2-hour occlusion, mannitol clearly suppresses subsequent swelling; but after 6-hour occlusion, it was found that mannitol alone had little positive effect.
D000208:Acute Disease; D000818:Animals; D001812:Blood-Brain Barrier; D001929:Brain Edema / Q000517:prevention & control*; D002544:Cerebral Infarction / Q000188:drug therapy* / Q000503:physiopathology; D004285:Dogs; D005070:Evans Blue; D008353:Mannitol / Q000627:therapeutic use*; D013997:Time Factors
D008353:Mannitol; D005070:Evans Blue