title: [Noxytioline in the local treatment of empyema (author's transl)].
abstract: The importance assumed by local treatment in non-tuberculous purulent pleurisy has suggested that intrapleural applications of a broad spectrum antiseptic could be as useful as in peritonitis. Fifteen adult patients with empyema secondary, in most cases, to local, usually Gram-negative, infections were treated with combined antibiotic therapy and locally administered noxytioline. The patients underwent 3 to 30 intrapleural lavages (average 9) via a pleurotomy drainage tube (11 cases) or after pleural puncture (4 cases). Results were very satisfactory in 12 out of 15 cases, with mild pleural sequelae in 8 cases. No local or systemic reactions were observed. This treatment proved particularly effective in 5 difficult cases.
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009677:Noxythiolin / Q000378:metabolism / Q000627:therapeutic use*; D010998:Pleurisy / Q000188:drug therapy*; D013492:Suppuration; D013890:Thiourea / Q000031:analogs & derivatives*
chemical_list: D009677:Noxythiolin; D013890:Thiourea
vernacular_title: La noxytioline dans le traitement local des épanchements pleuraux purulents.