[Synthetic polymers as stimulators and prolonging agents of the immune action of the brucellosis protective antigen].
Among a number of synthetic polymers under study polyvinylpyrrolidone was found to be most active in stimulating the immunogenic action of brucellosis protective antigen. It was also found that the polymer with a molecular weight of 490,000 had a longer stimulating effect on the protective properties of brucellosis protective antigen than the polymer with a molecular weight of 40,000. The intramuscular injection of brucellosis protective antigen had no sensitizing effect on the body and produced no pronounced local and systemic reaction.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000942:Antigens, Bacterial / Q000276:immunology*; D002003:Brucella abortus / Q000276:immunology*; D002006:Brucellosis / Q000276:immunology; D003692:Delayed-Action Preparations; D004306:Dose-Response Relationship, Immunologic; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D011145:Polyvinyls / Q000276:immunology*; D011205:Povidone / Q000276:immunology*; D011725:Pyridines / Q000276:immunology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D003692:Delayed-Action Preparations; D011145:Polyvinyls; D011725:Pyridines; C019535:poly(4-vinylpyridine); D011205:Povidone
Izuchenie sinteticheskikh polimerov v kachestve stimuliatorov i prolongatorov immunogo deĭstviia brutselleznogo protektivnogo antigena.