title: Effects of aspirin treatment upon fibrinolytic activity of peripheral blood granulocytes.
abstract: The effects of in vivo acetylsalicylic acid (ASA) treatment on the fibrinolytic activity of peripheral blood granulocytes have been studied in a group of healthy volunteers. Following a 4-day treatment with aspirin at a dose of 1 g/day, both the plasminogen-dependent and the nonspecific fibrinolytic activity were significantly decreased. On the contrary, no significant change in the granulocyte fibrinolytic activity was found after treatment with 250 mg ASA/day. It is suggested that the cellular release mechanism of such lytic enzymes rather than their synthesis could have been affected by the drug.
mesh_terms: D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D006098:Granulocytes / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000494:pharmacology; D010958:Plasminogen / Q000378:metabolism
chemical_list: D010958:Plasminogen; D010447:Peptide Hydrolases; D001241:Aspirin