Ocular manifestations of the fetal hydantoin syndrome.
Eleven per cent of infants exposed to hydantoins in utero have a recognizable pattern of abnormalities with serious clinical consequences. This report of a child born to a mother taking diphenylhydantoin emphasized the ocular findings. At birth and subsequent 8-month exam, a girl was noted to have microphthalmus, prominent iris vessels, and an inferior iris and choroidal colobma. Relation of these anomalies to teratogenic properties of diphenylhydantoin is discussed.
D003103:Coloboma / Q000139:chemically induced; D005123:Eye / Q000187:drug effects* / Q000196:embryology; D005124:Eye Abnormalities; D005260:Female; D005315:Fetal Diseases / Q000139:chemically induced*; D006801:Humans; D007223:Infant; D008850:Microphthalmos / Q000139:chemically induced; D010672:Phenytoin / Q000009:adverse effects*; D011247:Pregnancy
D010672:Phenytoin