Effect of co-trimoxazole on the glomerular filtration rate of healthy adults.
The administration of co-trimoxazole to 10 healthy adult volunteers was associated with a significant rise in their mean plasma creatinine (by 17.6%: p less than 0.01) and decrease in their mean creatinine clearance (by 26.3%: p less than 0.01). However, glomerular filtration rate (calculated from 51Cr-EDTA clearance) did not show any significant change. It is concluded that the changes in plasma creatinine and creatinine clearance during co-trimoxazole administration are not due to a decrease in glomerular filtration rate.
D000328:Adult; D003404:Creatinine / Q000378:metabolism; D004338:Drug Combinations / Q000009:adverse effects; D004492:Edetic Acid / Q000378:metabolism; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D013420:Sulfamethoxazole / Q000009:adverse effects*; D014295:Trimethoprim / Q000009:adverse effects*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination
D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D004492:Edetic Acid; D014295:Trimethoprim; D003404:Creatinine; D013420:Sulfamethoxazole