Allogeneic H-2 dose not cross-react, at the helper T-cell level, with Hapten-modified Self.
Helper T cells raised in CBA mice and enriched in vitro with specificity for trinitrophenylmodified syngeneic spleen cells can activate hapten-modified B cells bearing Ik. These helper cells fail to activate B cells expressing any of six independent I-region haplotypes, indicating lack of cross-reactivity between hapten-self and allogeneic I-region products. Furthermore, hapten-derivatized allogeneic B cells are also not activated, demonstrating that the elements restricting T-cell function are poorly, if at all, cross-reactive.
D000818:Animals; D002478:Cells, Cultured; D003429:Cross Reactions; D005260:Female; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000276:immunology*; D006238:Haploidy; D006241:Haptens / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013154:Spleen / Q000166:cytology; D013601:T-Lymphocytes / Q000276:immunology*; D014301:Trinitrobenzenes / Q000494:pharmacology
D006183:H-2 Antigens; D006241:Haptens; D014301:Trinitrobenzenes