Specific benzodiazepine antagonist RO15-1788 and thirst-induced drinking in the rat.
Midazolam, a new water-soluble benzodiazepine, increased the water intake of water deprived rats. The effect was abolished by concurrent treatment with the benzodiazepine antagonist, RO15-1788. The lack of effect of RO15-1788 on phenobarbitone-induced hyperdipsia confirmed the specificity of the antagonist action. Alone RO15-1788 (0.3-30 mg . kg-1) had no effect on thirst-induced drinking. Thus, it was not necessary to posit the action of an endogenous benzodiazepine ligand in thirst-induced drinking.
D000818:Animals; D001569:Benzodiazepines / Q000494:pharmacology; D001570:Benzodiazepinones / Q000494:pharmacology*; D004327:Drinking Behavior / Q000502:physiology*; D004336:Drug Antagonism; D005442:Flumazenil; D008297:Male; D008874:Midazolam; D051381:Rats; D014868:Water Deprivation / Q000502:physiology*
D001570:Benzodiazepinones; D001569:Benzodiazepines; D005442:Flumazenil; D008874:Midazolam