[Development of bilirubin-UDP-glucuronosyltransferase (EC 2.4.1.17) and the concentration of transport proteins Y and Z of rat liver under postnatal hypoxia].
The development of bilirubin-UDP-glucuronyltransferase (bili.-UDP-GT) activity and the concentration of transport proteins Y and Z from the livers of Sprague-Dawley rats were studied in the first 20 days from birth and compared to the findings obtained on postnatally hypoxic rat newborns. The activity of bili.-UDP-GT is very low immediately after birth, and rises within the first 4 days to values distinctly exceeding adult values. Onset of hypoxia within the first 3 h of life inhibits the development of bili.-UDP-GT; later onset of hypoxia is without effect. The development of Y and Z transport proteins proceeds more slowly than that of bili.-UDP-GT. The binding properties of the Y protein in regard to substrate affinity. There is evidence in newborns for interactions in terms of cooperative binding. No influence of hypoxia on the development of Y and Z transport proteins is demonstrable.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D001663:Bilirubin / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism*; D005260:Female; D014453:Glucuronosyltransferase / Q000378:metabolism; D000860:Hypoxia / Q000378:metabolism*; D007202:Indicators and Reagents; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D012395:Rose Bengal
D002352:Carrier Proteins; D007202:Indicators and Reagents; D012395:Rose Bengal; D014453:Glucuronosyltransferase; D001663:Bilirubin
Zur Entwicklung der Aktivität der Bilirubin-UDP-Glukuronyltransferase (EC 2.4.1.17) und der Konzentration der Transportporteine Y und Z der Leber von Ratten unter postnataler Hypoxie.