The role of mucosal carbonic anhydrase in the protection of gastric mucosa against luminal H+.
Carbonic anhydrase is exceptionally abundantly present in the gastric mucosa, including the epithelia surface cells. Inhibition of carbonic anhydrase activity with acetazolamide enhances the susceptibility to ulceration in rabbit antrum. It also abolishes the protection against ulceration afforded by intravenous HCO3- in rats. Acetazolamide likewise abolishes the protection against ulceration afforded by the presence of HCO3- in the incubation medium for isolated frog gastric sacs. These findings suggest a protective function for carbonic anhydrase in gastric mucosa.
D000086:Acetazolamide / Q000494:pharmacology; D000818:Animals; D002256:Carbonic Anhydrases / Q000502:physiology*; D005744:Gastric Acid / Q000502:physiology*; D005753:Gastric Mucosa / Q000201:enzymology*; D011817:Rabbits; D011892:Rana catesbeiana; D051381:Rats; D013276:Stomach Ulcer / Q000209:etiology
D002256:Carbonic Anhydrases; D000086:Acetazolamide