4-Aminopyridine reversal of fentanyl-induced respiratory depression in normocapnic and hypercapnic patients.
Profound postoperative respiratory depression after larger doses of fentanyl was partially reversed by 4-aminopyridine. This reversal was independent of FIO2' suggesting that the response was not dependent upon peripheral chemoreceptor-mediated drive. Similar reversal of fentanyl-induced depression by 4-aminopyridine was observed before surgery in patients breathing 67% nitrous oxide in oxygen. 4-Aminopyridine had no effect on breathing when given alone in the absence of fentanyl to patients breathing 67% nitrous oxide in oxygen before surgery.
D000293:Adolescent; D000328:Adult; D000631:Aminopyridines / Q000494:pharmacology*; D000769:Anesthesia, Inhalation; D000771:Anesthesia, Intravenous; D002245:Carbon Dioxide / Q000097:blood*; D003864:Depression, Chemical; D005260:Female; D005283:Fentanyl / Q000037:antagonists & inhibitors*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide; D010100:Oxygen; D012119:Respiration / Q000187:drug effects*
D000631:Aminopyridines; D002245:Carbon Dioxide; D009609:Nitrous Oxide; D010100:Oxygen; D005283:Fentanyl