Comparison of the orally administered anti-allergy agent, ketotifen with sodium cromoglycate in the prophylaxis of bronchial asthma.
Ketotifen at an oral dose of 1 mg twice daily was compared with sodium cromoglycate a dose of 20 mg four times daily by inhalation in a double-blind parallel group study lasting 12 weeks. Data relating to 60 patients were analyzed and showed that stabilised asthmatics continued to be stable during the 12-week treatment period on both drugs. There was a significant reduction within the ketotifen group in day and night scores at the end of the 12-week period and more patients on ketotifen had increased evening peak expiratory flow rate values compared with sodium cromoglycate. Ketotifen and sodium cromoglycate were equally well tolerated.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D002986:Clinical Trials as Topic; D004205:Cromolyn Sodium / Q000008:administration & dosage / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007665:Ketotifen / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged
D004205:Cromolyn Sodium; D007665:Ketotifen