Induction of delayed-type hypersensitivity to azobenzenearsonate by a monoclonal anti-idiotype antibody.
Azobenzenearsonate (ABA)-specific sensitivity was induced in A/J mice by injecting a monoclonal anti-idiotype reagent, 14A, directed against a determinant present on a minor subpopulation of immunoglobulin molecules within the anti-ABA antibodies of A/J mice. Sensitivity was transferrable by purified T cells and this was abrogated by treating the cells with 14A, rabbit anti-mouse immunoglobulin and complement, not by treatment with only the last two reagents. The transfer was restricted by the K-end of the major histocompatibility complex.
D000818:Animals; D000906:Antibodies / Q000494:pharmacology*; D000911:Antibodies, Monoclonal; D001391:Azo Compounds / Q000276:immunology*; D002417:Cattle; D003165:Complement System Proteins; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007116:Immunization, Passive; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D008285:Major Histocompatibility Complex; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D011863:Radioimmunoassay; D013601:T-Lymphocytes / Q000276:immunology; D010132:p-Azobenzenearsonate / Q000276:immunology*
D000906:Antibodies; D000911:Antibodies, Monoclonal; D001391:Azo Compounds; D007130:Immunoglobulin Idiotypes; D010132:p-Azobenzenearsonate; D003165:Complement System Proteins