A marmoset T lymphoma which functions as a human amplifier T cell.
A long-term in vitro grown T cell line derived from a cotton-topped marmoset (Saguinus oedipus) infected with Herpesvirus saimiri was fond to share surface antigens with human amplifier T cells and to augment the capacity of human B cells to secrete immunoglobulin. This is the first demonstration of T/B collaboration across such a large phylogenetic barrier and might have interesting implications for understanding the nature of molecular interactions mediating cell/cell cooperation.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology; D000954:Antigens, Surface / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D002143:Callitrichinae / Q000276:immunology*; D002460:Cell Line; D006801:Humans; D008211:Lymphocyte Cooperation; D008223:Lymphoma / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000276:immunology; D013045:Species Specificity; D013601:T-Lymphocytes / Q000276:immunology*
D000951:Antigens, Neoplasm; D000954:Antigens, Surface