The immediate effect of sodium cromoglycate on the airway.
The authors compared the bronchodilator effect of nebulized solutions of sodium cromoglycate (SCG), salbutamol, and saline (placebo) in 10 asthmatic children, measuring peak expiratory flow (PEF), forced vital capacity (FVC), forced expiratory volume in one second (FEV1) and forced expiratory flow from 25% to 75% of the forced vital capacity (FEF25%-75%) before and every five minutes to a maximum of 20 minutes after each aerosol. SCG produced significant bronchodilation compared with saline as measured by PEF. This effect was not seen with FEV1 or FEF25%-75%. Salbutamol had a more immediate effect and produced a greater degree of bronchodilation than SCG. When an immediate bronchodilator effect is required SCG is not recommended.
D000402:Airway Obstruction / Q000188:drug therapy*; D000420:Albuterol / Q000627:therapeutic use; D001249:Asthma / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000627:therapeutic use; D002648:Child; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D012129:Respiratory Function Tests; D012965:Sodium Chloride / Q000627:therapeutic use; D013997:Time Factors
D001993:Bronchodilator Agents; D012965:Sodium Chloride; D004205:Cromolyn Sodium; D000420:Albuterol