title: Rejection of allogeneic tumor cells growing in mouse cerebrospinal fluid. Functional analysis of the inflammatory process.
abstract: Mice injected intracerebrally (i.c.) with mastocytoma cells reject the tumor, which grows rapidly in cerebrospinal fluid (CSF), within 7 or 8 days. The characteristics of the inflammatory exudate have been examined by several different, functional criteria. Potent cytotoxic T-lymphocyte populations are readily demonstrated in CSF, and both phagocytic and non-phagocytic cells capable of mediating antibody-dependent cell-mediated cytotoxicity are also present. However, no tumor-specific antibody was detected in CSF of mice that had recently rejected the tumor, using sensitive complement-dependent and lymphocyte-dependent cytotoxic assay systems. The process of cell-mediated tumor rejection does not obviously compromise the blood-CSF barrier to immunoglobulins.
mesh_terms: D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D002555:Cerebrospinal Fluid / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D006084:Graft Rejection; D007249:Inflammation / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D012515:Mast-Cell Sarcoma / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000276:immunology*; D014184:Transplantation, Homologous