Effect of a new pyrimidine analog on Bacillus subtilis growth.
2-Amino-5-ethoxycarbonylpyrimidine-4(3H)-one, a pyrimidine analog, inhibited growth of Bacillus subtilis. Data were obtained which suggested that the analog interfered with the methylation process. A mutant resistant to the inhibitor was isolated, and the mutation was mapped.
D001412:Bacillus subtilis / Q000187:drug effects* / Q000254:growth & development; D002874:Chromosome Mapping; D004352:Drug Resistance, Microbial; D008715:Methionine / Q000378:metabolism; D008745:Methylation; D011743:Pyrimidines / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D011743:Pyrimidines; D008715:Methionine