title: [Distribution of rabies antigen in the central nervous system of rats and mice experimentally infected with rabies strains isolated from hamsters (Cricetus cricetus)].
abstract: The comparative experiments were carried out to study the distribution of the rabies antigen in the central nervous system (CNS) of sewer-rats and mice experimentally infected with three "hamster" strains (for comparison also with "fox" strain 1151); it was found out that with microscopical observation of preparations stained by the method of direct immunofluorescence the "hamster" strains produced a blended picture of fluorescing particles characteristic of strains with a reduced virulence and virulent strains. As for mice infected with strains 3 O and 7 E the rabies antigen was detected in all parts of CNS as early as 24 hours after infection. In this period the rabies antigen strain 9 E was not detected in lumbar spinal cord and that with strain 1151 was detected only in the Ammonian horns. After 48 hours the rabies antigen in mice was detected in all parts of CNS with all four strains used. In sewer-rats, with regard to their lower susceptibility to the rabies virus, the first detection of rabies antigen in CNS was recorded on the 6th day after infection with strains 3 O, 7 E and 1151, whereas with strain 9 E as late as the 9th day in lumbar spinal cord and not in all animals.
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis*; D002490:Central Nervous System / Q000276:immunology*; D006224:Cricetinae / Q000382:microbiology; D051379:Mice; D011818:Rabies / Q000276:immunology / Q000662:veterinary*; D011820:Rabies virus / Q000276:immunology* / Q000302:isolation & purification; D051381:Rats; D012376:Rodent Diseases / Q000276:immunology*
chemical_list: D000956:Antigens, Viral
vernacular_title: Distribúcia rabického antigénu v CNS potkanov a mysí experimentálne infikovaných kmenmi vírusu besnoty izolovanými z chrckov rol'ných (Cricetus cricetus).