Growth, food intake, motor activity and experimental cardiac necrosis in early malnourished male rats.
Male rats with protein energy malnutrition from birth to the 49th day of life (PEM) and then receiving normal diet ad libitum had lower body weights and relatively higher food intakes (g/100 g body weight) than controls (C). Spontaneous motor activity measured in rotation wheels from the 42nd day was higher in previously malnourished animals, but less food was consumed per gram of weight increment during this period by PEM rats as compared to C rats. The cardiotoxicity of isoprenaline administered at the age of 110 days was significantly lower, i.e. the cardiac damage was smaller in previously malnourished animals (PEM). This was most apparent when they were compared with inactive controls living in standard laboratory cages.
D000375:Aging; D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced* / Q000473:pathology; D004032:Diet; D006128:Growth; D007545:Isoproterenol; D008297:Male; D009043:Motor Activity / Q000502:physiology*; D009206:Myocardium / Q000473:pathology; D009336:Necrosis; D009929:Organ Size; D011502:Protein-Energy Malnutrition / Q000473:pathology / Q000503:physiopathology*; D051381:Rats
D007545:Isoproterenol