title: [101/H line mice, a possible model of human chromosomal instability diseases].
abstract: Chromosome aberrations were studied in cells of embryo liver of 101/H and CBA mice following mutagenic treatment with the alkylating agent--thiophosphamide. Higher sensitivity of chromosomes to aberration induction was found in 101/H mice. After crossing thiophosphamide treated 101/H and CBA males to untreated 101/H and CBA females, the lowest output of dominant lethal mutations was found in the progeny of 101/H females. It is suggested that the 101/H mice are a possible model of inherited diseases with chromosomal instability.
mesh_terms: D000818:Animals; D002869:Chromosome Aberrations / Q000139:chemically induced / Q000235:genetics*; D025063:Chromosome Disorders; D004195:Disease Models, Animal; D005260:Female; D005313:Fetal Death / Q000139:chemically induced / Q000235:genetics; D005799:Genes, Dominant / Q000187:drug effects; D005804:Genes, Lethal / Q000187:drug effects; D006801:Humans; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains / Q000235:genetics*; D009154:Mutation; D011247:Pregnancy; D013852:Thiotepa / Q000494:pharmacology
chemical_list: D013852:Thiotepa
vernacular_title: Myshi linii 101/H--vozmozhnaia model' zabolevaniĭ cheloveka s khromosomnoĭ nestabil'nost'iu.