Effect of organic thio-compounds on detoxication of glucuronyltransferase and beta-glucuronidase in the rat liver.
In this study, an effect of single administration of organic thio-compounds on the combined use with uridine diphosphate glucuronic acid was investigated. In the single administration of organic thio-compounds to Wistar strain rats, the synthesis of glucuronide was slightly accelerated by glutathione or methionine, but it was not so much as in the single administration of UDPGA. The glucuronyltransferase activity was accelerated, when either taurine or methionine was administered in combination with UDPGA. None of these organic thio-compounds used in this study showed more significant inhibitory action of beta-glucuronidase activity than UDPGA in the single administration. It was perceived, however that the inhibitory action of beta-glucuronidase activity was much accelerated, when UDPGA was administered in combination either with taurine or methionine. In the administration of organic thio-compounds to Gunn strain rats, cysteine was detected to be the compound which accelerated the synthesis of glucuronide. It was also noted that no organic thio-compounds used in this study affected as influence on beta-glucuronidase activity.
D000818:Animals; D005966:Glucuronidase / Q000378:metabolism*; D014453:Glucuronosyltransferase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D013438:Sulfhydryl Compounds / Q000494:pharmacology*
D013438:Sulfhydryl Compounds; D014453:Glucuronosyltransferase; D005966:Glucuronidase