Development of multiple antibodies in an apparently 'protected' Rh D negative mother.
A case is described of a group O Rh (D) negative woman who received a blood transfusion after the delivery of her first infant, blood group O Rh (D) negative. In her second pregnancy anti-S was detected, presumably due to the prior transfusion. The second infant was D+S+ and the direct antiglobulin test on this infant's cells was positive. As no anti-D antibodies were detectable in this pregnancy, the positive antiglobulin test was presumably due to the anti-S. Anti-D immunoglobulin was administered after this pregnancy, but in spite of this the mother developed a strong anti-D antibody. The significance of this 'failure of protection' is discussed in relation to the augmenting affect of antibody development during pregnancy.
D000328:Adult; D000917:Antibody Formation; D004375:Duffy Blood-Group System / Q000276:immunology; D005260:Female; D006801:Humans; D008951:MNSs Blood-Group System / Q000276:immunology; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D065227:Transfusion Reaction
D004375:Duffy Blood-Group System; D008951:MNSs Blood-Group System; D012204:Rh-Hr Blood-Group System