Neurofibromatosis in monozygotic twins: a case report of spontaneous mutation.
We report female monozygotic twins with neurofibromatosis. The family history is unremarkable, and careful examination of other family members did not show evidence of the condition. It is concluded that the occurrence in this family is due to a spontaneous mutation arising in one of the parental gametes. This article examines the similarity and difference in manifestations of the disorder in this pair of monozygotic twins.
D003390:Cranial Nerve Neoplasms / Q000209:etiology; D004200:Diseases in Twins; D005260:Female; D005910:Glioma / Q000209:etiology; D006801:Humans; D007231:Infant, Newborn; D009154:Mutation; D009456:Neurofibromatosis 1 / Q000150:complications / Q000235:genetics*; D009901:Optic Nerve Diseases / Q000209:etiology; D011247:Pregnancy; D012880:Skin Pigmentation; D014427:Twins; D014430:Twins, Monozygotic