[Inhibitory action of diphosphonate on the development of pancreatic concrements (experiment with EHDP (author's transl)].
The application of the diphosphonate EHDP (ethane-I-hydroxy-I,I-diphosphonate) prior to the commencement of a calciphylactic experiment (SELYE) inhibits the interstitial calcification and fixation of apatite in the pancreas of female rats (dosage: 20 mgEHDP i. p. per 150 g body mass). Thus the inhibitory potency of EHDP on soft tissue calcification is confirmed. Previously, on the basis of experimental results, a therapeutic administration of this substance in the field of clinical pancreatology could not be derived because the most of human intraductal calculi is composed of calcium carbonate.
D000818:Animals; D002114:Calcinosis / Q000517:prevention & control; D002137:Calculi / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D012968:Etidronic Acid / Q000627:therapeutic use*; D005260:Female; D007505:Iron-Dextran Complex / Q000009:adverse effects; D010179:Pancreas / Q000473:pathology; D010182:Pancreatic Diseases / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D051381:Rats
D007505:Iron-Dextran Complex; D012968:Etidronic Acid
Diphosphonat als Inhibitor einer Konkrementbildung im Pankreas (Tierversuche mit AHDP).