Sex-linked lethal mutations induced in Drosophila melanogaster by 7,12-dimethylbenz[a]anthracene.
One of the most potent carcinogens, 7,12-dimethylbenz[a]anthracene (DMBA), was tested for the induction of mutations in 2 strains of Drosophila melanogaster. Larvae were fed mixtures containing DMBA, peanut oil and solubilizing agents in darkness. After emergence the males were mated with Basc or FM7a females to test for sex-linked lethals. For Canton-S males, all DMBA treatments produced highly significant increases in mutation frequencies over controls. DMBA was slightly mutagenic for Oregon-R males.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000187:drug effects*; D005799:Genes, Dominant / Q000187:drug effects; D005804:Genes, Lethal / Q000187:drug effects; D014644:Genetic Variation; D007814:Larva / Q000187:drug effects; D008297:Male; D009152:Mutagenicity Tests; D009154:Mutation; D012730:Sex Chromosomes / Q000187:drug effects*
D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene