[Reactivity of the H-2ba mutant against the products of the H-2Kb gene and its mutant alleles in the graft vs. host reaction and the linkage with the H-2 complex of the nonresponsiveness of B10.M mice against the H-2kbd antigen].
Five mutants for the H-2Kb gene within the mouse major histocompatibility complex were studied in the Simonsen spleen weight assay. It was shown that H-2Kba mutant was unable to react against only H-2Kbd recipients, while developed normal reaction against H-2Kbf, H-2Kbg2, H-2Kbh mutants. These results indicate the specific character of the nonresponsiveness. Mice of the B10.M (H-2f) strain do not complement the defect of reactivity in the H-2Kba mutant. Evidence from the study of G2 hybrids indicate that the gene for nonresponsiveness in B 10.M was linked with the H-2 complex.
D000483:Alleles; D000818:Animals; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D005838:Genotype; D006087:Graft vs Host Reaction; D006649:Histocompatibility Antigens / Q000235:genetics*; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains / Q000235:genetics*; D009154:Mutation
D006649:Histocompatibility Antigens
Reaktivnost' v "reaktsii transplantat protiv khoziaina" mutanta H-2ba protiv produktov gena H-2Kb i ego mutantnykh alleleĭ i stseplenie s kompleksom H-2 areaktivnosti mysheĭ B10.M protiv antigena H-2Kbd.