Anticonvulsant-induced status epilepticus in Lennox-Gastaut syndrome.
A 22-year-old woman with the Lennox-Gastaut syndrome developed serial apnoeic-tonic seizures with concomitant bursts of repetitive spikes at 16-20/sec, after receiving therapeutic doses of chlormethiazole, clonazepam, and diazepam for the treatment of serial tonic-clonic generalized seizures. There was a direct relationship between dose of chlormethiazole and frequency of apnoeic-tonic seizures. Since these tonic seizures have been noted during natural sleep and after sleep induced by various sedative drugs in patients with slow spike-wave in EEG, it is likely that the reduction in level of consciousness induced by sedative drugs is the causative factor.
D000293:Adolescent; D000328:Adult; D001570:Benzodiazepinones / Q000009:adverse effects*; D002220:Carbamazepine / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002719:Chlormethiazole / Q000009:adverse effects*; D002998:Clonazepam / Q000009:adverse effects*; D003975:Diazepam / Q000009:adverse effects*; D004338:Drug Combinations; D004569:Electroencephalography; D004832:Epilepsy, Absence / Q000188:drug therapy*; D005260:Female; D006801:Humans; D010672:Phenytoin / Q000627:therapeutic use; D011324:Primidone / Q000627:therapeutic use; D013226:Status Epilepticus / Q000139:chemically induced* / Q000503:physiopathology
D001570:Benzodiazepinones; D004338:Drug Combinations; D002719:Chlormethiazole; D011324:Primidone; D002220:Carbamazepine; D002998:Clonazepam; D010672:Phenytoin; D003975:Diazepam