[In vitro modification of the morphology and the growth of cells infected with scrapie (author's transl)].
Seven cell lines originated either in brains or in neuroblastomas of Mice, were infected with Scrapie. After 12 to 16 in vitro passages, 6 lines out of 7 showed changes of their morphology, and of their growth, resembling those occurring in the course of a malignant transformation. The Scrapie infected cells acquired the capacity to form 2 to 4 times more colonies in liquid medium than the controls, and to develop large tridimensional colonies in semisolid medium. The role of Scrapie in these changes is discussed.
D000818:Animals; D001921:Brain / Q000382:microbiology*; D001932:Brain Neoplasms / Q000382:microbiology* / Q000473:pathology; D002460:Cell Line; D002471:Cell Transformation, Neoplastic; D002472:Cell Transformation, Viral; D051379:Mice; D009374:Neoplasms, Experimental / Q000382:microbiology / Q000473:pathology; D009447:Neuroblastoma / Q000382:microbiology* / Q000473:pathology; D011328:Prions / Q000235:genetics*
D011328:Prions
Modifications in vitro de la morphologie et de la croissance de cellules infectées par l'agent scrapie.