[Toxicity of hydroxyquinoline derivatives].
We studied a 90 day toxicity in dogs of the compound broxyquinoline + broxaldine--5:1 (enteroquin), applied orally and daily in doses of 0.1 and 0.2/kg t/24 h. We established the toxic manifestations during the period after the 15th day of the treatment: leukopenia, neutropenia and lymphocytosis (by 0.2 kg t/24 h). After the second and fifth day we observed a decrease of appetite, depression of the CNS, paralyses, arrhythmia, progressing loss in weight, proteinorrhea (more pronounced with those receiving 0.2/kg t (24 h); lethal consequence with some part of the animals 25% (ba 0.1/kg t) and 50% (by 0.2 kg t). We found out pathohistologically necrobiotic changes in the medulla oblongata and the kidneys, toxic distrophy of the liver, blood-vessel injuries. The toxic changes observed can be interpreted in connection with the presence of a species specific reaction.
D000818:Animals; D001769:Blood / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations / Q000633:toxicity; D006912:Hydroxyquinolines / Q000633:toxicity*; D007928:Lethal Dose 50; D015125:Oxyquinoline / Q000031:analogs & derivatives / Q000633:toxicity*; D011798:Quinaldines / Q000633:toxicity*; D011804:Quinolines / Q000633:toxicity*; D013997:Time Factors
D004338:Drug Combinations; D006912:Hydroxyquinolines; D011798:Quinaldines; D011804:Quinolines; D015125:Oxyquinoline; C001454:brobenzoxaldine, broxyquinoline drug combination
Prouchvaniia vŭrkhu toksichnostta na niakoi khidroksikhinolinovi proizvodni.