[Repair of DNA injuries induced by thiophosphamide in embryonal fibroblasts of 101/H and CBA mice].
A study was made of changes in the molecular weight of one-strand fragments of DNA after a short-term treatment with thiophosphamide given in high concentrations of 101/H and CBA mouse cells. The data obtained indicate that DNA lesions induced by thiophosphamide occur and increase with time. It is assumed that the site of lesion is inter-strand cross-links of DNA. Mouse cells were disclosed to be able to repair the thiophosphamide-induced DNA lesions. Repair of DNA cross-links proceeds more effectively in 101/H mouse cells than in those of CBA mice.
D000818:Animals; D002478:Cells, Cultured; D004260:DNA Repair; D004277:DNA, Single-Stranded / Q000032:analysis*; D004622:Embryo, Mammalian; D005347:Fibroblasts / Q000187:drug effects / Q000648:ultrastructure*; D051379:Mice; D008808:Mice, Inbred CBA; D008970:Molecular Weight; D013852:Thiotepa / Q000633:toxicity*
D004277:DNA, Single-Stranded; D013852:Thiotepa
Reparatsiia povrezhdeniĭ DNK, indutsirovannykh tiofosfamidom v émbrional'nykh fibroblastakh mysheĭ liniĭ 101/H i CBA.