title: Thyrotrophin-producing pituitary adenomas.
abstract: Hyperthyroidism due to thyrotrophin (TSH)-secreting pituitary tumors is rare. Four cases are described, with the features that allow preoperative diagnosis. In all the patients, thyroid hormone production was consistently elevated despite antithyroid therapy, and TSH levels were inappropriately elevated. All patients were treated with both surgery and irradiation. Each patient had recurrent tumor with suprasellar, intrasphenoidal, or intraorbital spread. The combination of a recurrent, aggressive tumor complicated by thyrotoxicosis makes this a complex and difficult surgical problem.
mesh_terms: D000236:Adenoma / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000601:surgery; D000293:Adolescent; D000328:Adult; D005094:Exophthalmos / Q000209:etiology; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000209:etiology; D008875:Middle Aged; D010911:Pituitary Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000601:surgery; D013972:Thyrotropin / Q000097:blood / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000502:physiology; D014057:Tomography, X-Ray Computed
chemical_list: D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin