Antigenic similarity of toxins produced by Clostridium botulinum type C and D strains.
Antisera against purified type C1 toxin of Clostridium botulinum and its heavy-chain component cross-neutralized type D toxin. Antisera against partially purified type D toxin cross-neutralized type C1 toxin. From the latter serum, a component which neutralized only type D toxin and a component which equally neutralized both C1 and D toxins were obtained. We concluded that the cross-neutralization was not due to the fact that type C and D strains produce both C1 and D toxins but rather to the fact that the toxins have an antigen(s) common to their molecules. The results of the agar gel-double-diffusion test also supported this conclusion.
D000918:Antibody Specificity; D000942:Antigens, Bacterial / Q000276:immunology; D001905:Botulinum Toxins / Q000276:immunology* / Q000302:isolation & purification; D003014:Clostridium botulinum / Q000276:immunology; D003429:Cross Reactions; D004591:Electrophoresis, Polyacrylamide Gel; D007106:Immune Sera; D005779:Immunodiffusion; D009498:Neurotoxins / Q000276:immunology / Q000302:isolation & purification; D009500:Neutralization Tests
D000942:Antigens, Bacterial; D007106:Immune Sera; D009498:Neurotoxins; D001905:Botulinum Toxins