Anti-spectrin in sera containing smooth muscle autoantibodies from patients with chronic active hepatitis.
Sera from patients with chronic active hepatitis containing anti-smooth muscle autoantibodies (SMA) react against rabbit muscle actin as well as human red cell spectrin. These anti-spectrin antibodies recognize the same antigen as rabbit anti-human spectrin antibodies and are not involved in the staining pattern given by SMA-containing sera tested with smooth muscle sections. These anti-spectrin antibodies probably recognize an antigenic structure common to both spectrin and another as yet undetermined molecule (which however is not likely to be myosin).
D000199:Actins / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis*; D002908:Chronic Disease; D004591:Electrophoresis, Polyacrylamide Gel; D006505:Hepatitis / Q000276:immunology*; D006801:Humans; D005779:Immunodiffusion; D008565:Membrane Proteins / Q000276:immunology*; D009130:Muscle, Smooth / Q000276:immunology*; D013049:Spectrin / Q000276:immunology*
D000199:Actins; D001323:Autoantibodies; D008565:Membrane Proteins; D013049:Spectrin