Multiple angiitis of mesenterial arteries in guinea pigs induced by intraperitoneal administration high doses of Na2EDTA. I. Light microscopic study.
In this experiment multiple angiitis in various phases was demonstrated after intraperitoneal administration of high doses of Na2EDTA. These vascular manifestations induced by hyperexudation may probably be provoked by the loosening of the vascular wall which was caused by the releasing of calcium ions from its structure. In addition to its functional importance, such as muscular contraction, nerve transmission and the cell junction, the calcium ion is more important for the alteration of the molecular structure of acid mucopolysaccharides. Intraperitoneal administration of high doses of Na2 EDTA resulted in dissociation of hte intermuscular spaces with endothelial cell reaction. The metamorphosis of the vascular muscle cells into spindle shaped one could also be demonstrated. The hyperexudation caused by the above procedures induced angiitis-like lesions with round cell infiltration.
D000818:Animals; D004492:Edetic Acid / Q000009:adverse effects*; D005260:Female; D006168:Guinea Pigs; D007274:Injections, Intraperitoneal; D008297:Male; D008638:Mesenteric Arteries / Q000473:pathology*; D014657:Vasculitis / Q000139:chemically induced / Q000473:pathology*
D004492:Edetic Acid