[Histochemical demonstration of enzyme activity changes in the regio postcentralis of the mouse brain under the effect of the aging process].
The distribution of some oxidoreductases were investigated in the regio postcentralis of young, adult and senescent mice brains by means of semiquantitative histoenzymatic methods. It was possible to observe a different spread of activities of 1-malate: NAD oxidoreductase (EC 1.1.1.37) and D-glucose-6-phosphate: NADP oxidoreductase (EC 1.1.1.49) in several layers of the regio postcentralis between young and old animals. The enzyme products of 1-glutamate:NAD(P) oxidoreductase (EC 1.4.1.3), 1-alpha-glycerine-3-phosphate:NAD oxidoreductase (EC 1.1.1.8) and D-glucose-6-phosphate:NADP oxidoreductase (EC 1.1.1.49) in the whole area show a decrease after the 20th month of the life, but it exists strain differences. The investigated enzymes of citric acid cycle were not vary in the ageing process.
D000375:Aging; D000818:Animals; D002540:Cerebral Cortex / Q000201:enzymology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D005993:Glycerolphosphate Dehydrogenase / Q000378:metabolism; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008291:Malate Dehydrogenase / Q000378:metabolism; D051379:Mice; D008815:Mice, Inbred Strains; D010088:Oxidoreductases / Q000378:metabolism*; D013385:Succinate Dehydrogenase / Q000378:metabolism
D007527:Isoenzymes; D010088:Oxidoreductases; D005993:Glycerolphosphate Dehydrogenase; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D013385:Succinate Dehydrogenase; D005969:Glutamate Dehydrogenase
Histochemisch erfassbare Enzymaktivitätsveränderungen der Regio postcentralis des Mäusehirnes unter dem Einfluss des Alterungsprozesses.