Dichloromethane and carbon monoxide inhalation: carboxyhemoglobin addition, and drug metabolizing enzymes in rat.
Male Wistar rats were exposed for 3 h to 100 ppm Co, 1,000 ppm dichloromethane, or to their combination. Exposure to dichloromethane alone or in combination with CO double the ethoxycoumarin O-deethylase activity in the kidney microsomes but not in the liver. An additive effect on blood COHb concentration by simultaneous exposure to CO and dichloromethane was observed. The mechanism of the additive effect is discussed.
D015660:7-Alkoxycoumarin O-Dealkylase; D000818:Animals; D002248:Carbon Monoxide / Q000494:pharmacology*; D002263:Carboxyhemoglobin / Q000032:analysis*; D019363:Cytochrome P-450 CYP1A1; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006454:Hemoglobins / Q000032:analysis*; D006843:Hydrocarbons, Chlorinated / Q000494:pharmacology*; D007668:Kidney / Q000201:enzymology; D008297:Male; D008752:Methylene Chloride / Q000494:pharmacology*; D008861:Microsomes / Q000201:enzymology*; D008862:Microsomes, Liver / Q000201:enzymology; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D010088:Oxidoreductases / Q000378:metabolism; D010105:Oxygenases / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D006454:Hemoglobins; D006843:Hydrocarbons, Chlorinated; D008752:Methylene Chloride; D002248:Carbon Monoxide; D003577:Cytochrome P-450 Enzyme System; D002263:Carboxyhemoglobin; D010088:Oxidoreductases; D010105:Oxygenases; D015660:7-Alkoxycoumarin O-Dealkylase; D019363:Cytochrome P-450 CYP1A1; D009251:NADPH-Ferrihemoprotein Reductase