[Ratio of the mutation spectrum to the physiological state of the Penicillium chrysogenum cell. Auxotrophic mutations induced by N-nitroso-N-methylbiuret in exposure at different stages of DNA replication].
The effect of UV light on activated conidia of Penicillium chrysogenum, strain 39 was studied. It was found that the spectrum of the auxotrophic mutations induced by UV light during replication of DNA changed with the dose of the mutagen and was specific to every dose. The schemes of predominating mutation induction during DNA replication under the effect of 2 doses of UV light were developed.
D001737:Biuret / Q000031:analogs & derivatives* / Q000494:pharmacology; D004261:DNA Replication / Q000187:drug effects*; D004271:DNA, Fungal / Q000096:biosynthesis*; D009153:Mutagens / Q000494:pharmacology*; D009154:Mutation; D009602:Nitrosamines / Q000494:pharmacology*; D010407:Penicillium / Q000187:drug effects*; D010408:Penicillium chrysogenum / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors; D014508:Urea / Q000031:analogs & derivatives*
D004271:DNA, Fungal; D009153:Mutagens; D009602:Nitrosamines; C008654:N-nitroso-N-methylbiuret; D001737:Biuret; D014508:Urea
Zavisimost' spektra mutatsiĭ ot fiziologicheskogo sostoianiia kletki Penicillium chrysogenum. Auksotrofnye mutatsii, indutsirovannye N-nitrozo-N-metilbiuretom pri vozdeĭstvii na raznye stadii replikatsii DNK.