title: Immunocytochemical localization of immunoglobulins in the inflammatory lesions of polymyositis.
abstract: Biopsy material from the muscles of 40 patients with either polymyositis or dermatomyositis was examined with the immunoperoxidase method to compare the distribution of immunoglobulin (Ig)-containing cells in the inflammatory infiltrates and elsewhere in the muscle tissue. Large numbers of IgG-positive and occasional IgM-positive cells were found in the infiltrates in 23 of these biopsies in contrast to the rather sparse representation of plasma cells. It is suggested that the Ig-containing cells may either represent local B-cell differentiation and proliferation or that the cells are involved in antibody-dependent cell-mediated tissue damage.
mesh_terms: D000328:Adult; D000368:Aged; D002675:Child, Preschool; D003176:Complement C3 / Q000276:immunology; D003882:Dermatomyositis / Q000276:immunology; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D007074:Immunoglobulin G / Q000276:immunology; D007143:Immunoglobulin Heavy Chains / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D007136:Immunoglobulins / Q000032:analysis*; D008214:Lymphocytes / Q000276:immunology; D009132:Muscles / Q000276:immunology; D009220:Myositis / Q000276:immunology*; D010950:Plasma Cells / Q000276:immunology
chemical_list: D003176:Complement C3; D007141:Immunoglobulin Fc Fragments; D007074:Immunoglobulin G; D007143:Immunoglobulin Heavy Chains; D007075:Immunoglobulin M; D007136:Immunoglobulins