Effect of thyrotropin-releasing hormone on 22Na uptake by the pond snail Helisoma carabaceum.
The effect of thyrotropin-releasing hormone, added to the external environment, on in vivo Na+ uptake by Helisoma carabaceum was assessed. It was found that 10(-5) M TRH significantly decreased unidirectional sodium flux. The Na+ concentration in the tissues and hemolymph was not affected by the hormone. Histidyl-proline-diketopiperazine, a TRH-metabolite, had no effect on Na+ uptake in vivo.
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D006458:Hemolymph / Q000378:metabolism; D007700:Kinetics; D012908:Snails / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D013973:Thyrotropin-Releasing Hormone; D012964:Sodium