title: The biosynthetic pathway of the asparagine-linked oligosaccharides of glycoproteins.
abstract: This review deals with the structure and addition of the different types of oligosaccharides to asparagine residues in proteins. This process occurs in several steps, first an oligosaccharide which contains N-acetylglucosamine mannose and glucose is built up joined to dolichyl diphosphate. The oligosaccharide is then transferred to a polypeptide chain, loses its glucose, and is modified by removal of some monosaccharides and addition of others giving rise to a variety of saccharides.
mesh_terms: D000117:Acetylglucosamine / Q000378:metabolism; D000118:Acetylglucosaminidase / Q000378:metabolism; D000818:Animals; D001216:Asparagine / Q000378:metabolism; D002478:Cells, Cultured; D004288:Dolichol Phosphates / Q000378:metabolism*; D004286:Dolichols / Q000378:metabolism; D005658:Fungi / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006023:Glycoproteins / Q000096:biosynthesis*; D006801:Humans; D007313:Insecta / Q000378:metabolism; D008358:Mannose / Q000378:metabolism; D017038:Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; D008954:Models, Biological; D009844:Oligosaccharides / Q000096:biosynthesis*; D010455:Peptides / Q000378:metabolism*; D010944:Plants / Q000378:metabolism; D011106:Polyisoprenyl Phosphates / Q000378:metabolism*; D014780:Viruses / Q000378:metabolism
chemical_list: D004288:Dolichol Phosphates; D004286:Dolichols; D006023:Glycoproteins; D009844:Oligosaccharides; D010455:Peptides; D011106:Polyisoprenyl Phosphates; C028306:dolichol monophosphate; C026406:dolichol pyrophosphate; D001216:Asparagine; D000118:Acetylglucosaminidase; D017038:Mannosyl-Glycoprotein Endo-beta-N-Acetylglucosaminidase; D005947:Glucose; D008358:Mannose; D000117:Acetylglucosamine