title: Behavioural and body temperature effects of meningococcal lipopolysaccharide after intraventricular injection in adult fowls Gallus domesticus.
abstract: The effects of the meningococcal lipopolysaccharide (LPS), given into the II cerebral ventricle of adult fowls, were studied on behaviour and body temperature. Immediately after the administration a marked and dose- dependent behavioural sedation or sleep lasting over 2 hours or more according to the dose was observed. The body temperature effects of LPS were biphasic, i.e. and immediate initial phase of hypothermia lasting about 100 min, followed by a longer-lasting fever response. A pretreatment with phentolamine, an antagonist at alpha-adrenoceptors prevented the hypothermic phase following the endotoxin administration. In conclusion, present experiments show that in comparison to 0-somatic antigen of Shigella dysenteriae, meningococcal endotoxin possesses more marked behavioural effects and a different profile in body temperature effects.
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007276:Injections, Intraventricular; D008070:Lipopolysaccharides / Q000633:toxicity*; D009345:Neisseria meningitidis / Q000472:pathogenicity; D010646:Phentolamine / Q000494:pharmacology; D011200:Poultry; D011458:Prostaglandins E / Q000378:metabolism
chemical_list: D008070:Lipopolysaccharides; D011458:Prostaglandins E; D010646:Phentolamine