Lack of susceptibility of congenitally athymic nude mice to human non-A, non-B hepatitis.
Nude mice were inoculated intravenously with chimpanzee serum containing a human non-A, non-b hepatitis agent. Control groups of nude mice were inoculated with normal saline or normal chimpanzee serum. During 77 days of observation, evidence of non-A, non-B hepatitis was not detected. Serum alanine aminotransferase levels remained within normal limits, and normal liver histology was seen in serially killed mice.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D005260:Female; D006526:Hepatitis C / Q000276:immunology*; D006525:Hepatitis, Viral, Human / Q000276:immunology*; D008099:Liver / Q000473:pathology; D051379:Mice; D008819:Mice, Nude / Q000276:immunology*
D000410:Alanine Transaminase