title: [A new synthetic antibacterial : 1-ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxo-1, 4-dihydroquinolin-3-carboxylic acid (1589 R.B.)].
abstract: The 1,4-dihydro-1-ethyl-6-fluoro-7-(4-methyl-1-piperazinyl)-4-oxoquinoline- 3-carboxylic acid (1589 R.B.) is a broad antibacterial agent active in experimental infections. The toxicological and pharmacokinetic profiles of the compound administered as methane sulfonic salt (1589 m R.B.), seem to suggest the possibility of using it in systemic infections.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D004285:Dogs; D006801:Humans; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007928:Lethal Dose 50; D051379:Mice; D015366:Pefloxacin; D011804:Quinolines / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats
chemical_list: D000900:Anti-Bacterial Agents; D011804:Quinolines; D015366:Pefloxacin
vernacular_title: Sur un nouvel antibactérien de synthèse : l'acide éthyl-1 fluoro-6 (méthyl-4 pipérazinyl-1)-7 oxo-4 dihydro-1.4 quinoléine-3 carboxylique (1589 R.B.).