Experimental intra-arterial infusion of Microencapsulated Mitomycin C into pelvic organs.
Laboratory experience with the use of Mitomycin C encased in ethylcellulose microcapsules as an agent for transcatheter embolisation is described. Microencapsulated Mitomycin C (MMC-m.c.) was infused into the pelvic organs of dogs by arterial catheterisation and the distribution of MMC in plasma and tissue was examined. MMC levels in the circulating blood of the MMC-m.c. group were significantly lower than those of the non-encapsulated MMC group. The biological potential of MMC was retained for prolonged periods in the pelvic organs after intra-arterial infusion of MMC-m.c. On the other hand, MMC could not be detected in the tissue of the non-encapsulated MMC group 4 h after the infusion.
D000818:Animals; D002214:Capsules; D002482:Cellulose / Q000031:analogs & derivatives; D003692:Delayed-Action Preparations; D004285:Dogs; D004621:Embolization, Therapeutic; D007261:Infusions, Intra-Arterial; D016685:Mitomycin; D008937:Mitomycins / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism; D010388:Pelvis / Q000378:metabolism*
D002214:Capsules; D003692:Delayed-Action Preparations; D008937:Mitomycins; D016685:Mitomycin; C013517:ethyl cellulose; D002482:Cellulose