Studies of carbachol-induced wet-dog shake behavior in rats.
Intraventricular administration of carbachol chloride evoked wet-dog shakes (WDS) in rats in a dose-related manner. WDS induced by carbachol at the dose of 20 microgram were antagonized by scopolamine, atropine, cyproheptadine, morphine, clonidine, phentolamine, haloperidol, and L-5-hydroxytryptophan (5-HTP). Methergoline, propranolol, bicuculline, and aminooxyacetic acid had no effect on carbachol-induced shaking behavior. The present experiments show the existence of different types of shaking behavior, not exclusively related to the stimulation of central 5-HT structures.
D000818:Animals; D002217:Carbachol / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006801:Humans; D007276:Injections, Intraventricular; D008297:Male; D051381:Rats; D013239:Stereotyped Behavior / Q000187:drug effects*
D002217:Carbachol