Arachidonic acid metabolism by cultured mesothelial cells. Different transformations of exogenously added and endogenously.
The capacity of cultured mesothelial cells to produce prostaglandins from both exogenous an endogenous arachidonic acid has been investigated. Incubations with labelled [1-14C]arachidonic acid and [1-14C]prostaglandin endoperoxide H2 indicated the formation of prostacyclin and prostaglandin E2. Evaluation of the transformation of endogenously released arachidonic acid, however, could only confirm the production of prostacyclin.
D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D002478:Cells, Cultured; D015232:Dinoprostone; D011464:Epoprostenol / Q000096:biosynthesis*; D005978:Glutathione / Q000494:pharmacology; D013058:Mass Spectrometry; D009852:Omentum / Q000378:metabolism*; D011450:Prostaglandin Endoperoxides, Synthetic / Q000378:metabolism; D044262:Prostaglandin H2; D011453:Prostaglandins / Q000096:biosynthesis*; D011458:Prostaglandins E / Q000096:biosynthesis*; D011463:Prostaglandins H / Q000378:metabolism; D011817:Rabbits
D001095:Arachidonic Acids; D011450:Prostaglandin Endoperoxides, Synthetic; D011453:Prostaglandins; D011458:Prostaglandins E; D011463:Prostaglandins H; D016718:Arachidonic Acid; D044262:Prostaglandin H2; D011464:Epoprostenol; D005978:Glutathione; D015232:Dinoprostone