Plasminogen in the chick embryo. Transport and biosynthesis.
As part of a program to define potential roles for plasminogen activation during development, we have studied the metabolism of plasminogen in the chick embryo. Here we report that: 1) plasminogen is present in significant quantities in the yolk of fertile, unincubated eggs; 2) the zymogen can be translocated intact, from the yolk to the developing embryonic circulation; and 3) de novo synthesis of plasminogen occurs during the early phases of embryonic life. The combination of a reservoir of the zymogen in the yolk and protein biosynthesis thus ensures the availability of a substrate for enzymes which may participate in morphogenetic events occurring throughout embryonic life.
D000818:Animals; D001692:Biological Transport; D002642:Chick Embryo; D004530:Egg Yolk; D004789:Enzyme Activation; D005260:Female; D005779:Immunodiffusion; D007700:Kinetics; D008970:Molecular Weight; D010958:Plasminogen / Q000096:biosynthesis / Q000302:isolation & purification / Q000378:metabolism*
D010958:Plasminogen