[Influence of prenatal applicated centrophenoxine on the postnatal increase in weight of the Wistar rats (author's transl)].
It is found in the literature, that Centrophenoxine, an ester of Dimethylaminoethanol and p-Chlorphenoxyacetate, has a great influence on the increase in weight of embryos of Wistar-rats. In the light of the present researches on animals it is tested, if this adequate substance transformation effect of Centrophenoxine has a long lasting influence on the postnatal life, whereby the weight is considered as a parameter. Centrophenoxine was applied on the animals under test from 11-14 d post coitum that is during the time of embryogenesis. The test lasted over 5 generations. The animals were divided into 2 groups: In the first group Centrophenoxine was given to the first generation and the second to fifth generation of animals were paired each other; while in the other group each generation received this Centrophenoxine at the same time before birth. The weights of the young animals were taken at definite intervals and compared with that of the untreated control-animals as well as among themselves. The weight differences in the individual weighting times between the control and test groups were inconsiderable and were significant only in few cases. The results showed that Centrophenoxine applied prenatal has lost its weight increasing influence in the postnatal life. The reasons are discussed.
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D005260:Female; D006016:Glycolates / Q000494:pharmacology*; D002504:Meclofenoxate / Q000494:pharmacology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D011919:Rats, Inbred Strains
D006016:Glycolates; D002504:Meclofenoxate
Der Einfluss von pränatal appliziertem Centrophenoxin auf die postnatale Gewichtsentwicklung von Wistar ratten.