[In vitro and in vivo effect of cadmium microparticles on antibody receptors of alveolar macrophage membranes].
Microparticles of cadmium oxide inhibited antibody-mediated rosette formation by Rat alveolar macrophages. After 4 h of contact in vitro, the 50% inhibiting amount of the pollutant, expressed as metal-Cd, was about 6,000 ng per million cells. 48 h after exposure via the respiratory route, 3,000 hg of Cd per gram of rat fresh lung lowered the percentage of rosette-forming macrophages by about 25%.
D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D019187:Cadmium Compounds; D002462:Cell Membrane / Q000276:immunology; D066298:In Vitro Techniques; D007700:Kinetics; D008264:Macrophages / Q000276:immunology*; D008297:Male; D010087:Oxides; D010587:Phagocytosis; D051381:Rats; D011919:Rats, Inbred Strains; D011971:Receptors, Immunologic / Q000187:drug effects / Q000378:metabolism*; D012397:Rosette Formation
D019187:Cadmium Compounds; D010087:Oxides; D011971:Receptors, Immunologic; D002104:Cadmium; C029663:cadmium oxide
Effet du cadmium microparticulaire, in vitro et in vivo, sur les récepteurs membranaires d'anticorps des macrophages alvéolaires.