An antibody that recognizes a determinant common to S and s-bearing sialoglycoproteins.
We describe an antibody, made by an individual of the phenotype M+, N+, S+, s+, U+, that reacted only with ficin or papain-treated red blood cells, and that initially appeared to have anti-S specificity. However, further studies revealed that the antibody, which did not have anti-U specificity, recognized a determinant present on S+, s-, U+, and S-, s+, U+, but missing from S-, s-, U-, and S-, s-, U+, red blood cells. The specificity of this antibody is discussed in terms of current knowledge of the structure of the Ss sialoglycoprotein.
D000368:Aged; D001323:Autoantibodies / Q000096:biosynthesis / Q000276:immunology; D003298:Coombs Test; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D005361:Ficain / Q000494:pharmacology; D006801:Humans; D007163:Immunosorbent Techniques; D007518:Isoantibodies / Q000096:biosynthesis* / Q000276:immunology; D007626:Kell Blood-Group System / Q000276:immunology; D008951:MNSs Blood-Group System / Q000276:immunology*; D010206:Papain / Q000494:pharmacology; D012204:Rh-Hr Blood-Group System; D012795:Sialoglycoproteins / Q000276:immunology*
D001323:Autoantibodies; D007518:Isoantibodies; D007626:Kell Blood-Group System; D008951:MNSs Blood-Group System; D012204:Rh-Hr Blood-Group System; D012795:Sialoglycoproteins; D010206:Papain; D005361:Ficain