Studies on human phenylalanine Mono-oxygenase. I. Restricted expression.
Enzyme assays for phenylalanine mono-oxygenase have been performed on a variety of non-hepatic human cell types under varying conditions. The cell types studied were cultured fibroblasts, short-term lymphocyte cultures, long-term lymphoblastoid cultures, cultured amniotic fluid cells, hair roots and placental extracts. The cultured cells were assayed after growth under standard conditions and in the presence of a high concentration of substrate, a low concentration of end-product, added hydrocortisone or dexamethasone and under combinations of these conditions. In no instance was a significant enzyme activity obtained.
D000653:Amniotic Fluid / Q000201:enzymology; D000818:Animals; D002460:Cell Line; D002478:Cells, Cultured; D005260:Female; D005347:Fibroblasts / Q000201:enzymology; D006197:Hair / Q000201:enzymology; D006801:Humans; D008099:Liver / Q000201:enzymology*; D008114:Liver Neoplasms, Experimental / Q000201:enzymology*; D008214:Lymphocytes / Q000201:enzymology; D051379:Mice; D009374:Neoplasms, Experimental / Q000201:enzymology; D010651:Phenylalanine Hydroxylase / Q000378:metabolism*; D010920:Placenta / Q000201:enzymology; D010954:Plasmacytoma / Q000201:enzymology*; D011247:Pregnancy; D051381:Rats; D012867:Skin / Q000201:enzymology*
D010651:Phenylalanine Hydroxylase