[Differences in the elimination of intravenously administered intralipid and lipofundin S].
Intravenous infusions of fat emulsions in different doses were performed using human volunteers. With both the dosages 0.1 gm/kg b.w. h and 0.25 gm/kg b.w. h) the elimination of intralipid was less effective than that of lipofundin S. During intralipid, therefore, significantly higher blood concentrations for triglycerides were attained. It is concluded, that different guidelines for the dosage of intravenous fat should be given. The kind of the preparation, e.e. the physical status of the fat particles and not merely the chemical composition, are obviously influencing the metabolic handling of intravenous fat. A strong monitoring of the patients triglyceride concentration during intravenous fat is recommended. An steady increase in serum triglyceride concentration or a significant lipemia should be an indication for the termination of the fat infusion.
D000328:Adult; D004338:Drug Combinations / Q000008:administration & dosage / Q000378:metabolism; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D010288:Parenteral Nutrition; D010743:Phospholipids / Q000008:administration & dosage / Q000378:metabolism*; D013012:Sorbitol / Q000008:administration & dosage / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
D004338:Drug Combinations; D005217:Fat Emulsions, Intravenous; D010743:Phospholipids; D014280:Triglycerides; C008288:Lipofundin; D013012:Sorbitol
Zur Frage der unterschiedlichen Elimination von intravenös verabreichtem Intralipid und Lipofundin S.