title: Correlative changes in the response to castration and the onset of refractoriness in male golden hamsters.
abstract: This investigation was designed to determine if a correlation exists between a change in the response of the hypothalamo-hypophysial axis to castration and the onset of refractoriness in male hamsters exposed to short days (in this case LD 6:18). The castration response, here defined as a significant increase in serum gonadotropins over levels in intact males, in males exposed to short days for 2 weeks was no different from that observed in long day males. On weeks 4 and 6 the response was greatly attenuated, and on weeks 8 and 10 no castration response was observed. Refractoriness was first observed in a few animals exposed to LD 6:18 for 8 weeks, and in increasing numbers of animals on weeks 10, 12, 13 and 14 of short-day treatment. Thus, short day exposure results in a simultaneous loss of response of the hypothalamo-hypophysial axis to castration and initiation of refractoriness.
mesh_terms: D000818:Animals; D002369:Castration; D006224:Cricetinae; D005640:Follicle Stimulating Hormone / Q000097:blood; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008647:Mesocricetus; D009929:Organ Size; D010775:Photic Stimulation; D012621:Seasons; D013737:Testis / Q000502:physiology*
chemical_list: D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone