Distribution of conduritol B epoxide in the animal model for Gaucher's disease (Gaucher mouse).
The time course of the distribution of the beta-glucosidase inhibitor [3H]conduritol B epoxide was determined in various organs of mice, which had received a single interperitoneal dose of the inhibitor. The epoxide is rapidly distributed over all tissues except brain where its concentration is only one-tenth of the average. This is considered an indication that the epoxide can pass the blood/brain barrier only with difficulty. A 4-fold enrichment is seen in the kidney. The inhibitor is excreted with a half-life of about 7 h; it is not metabolized. A parallel determination of beta-glucosidase activity in the tissues showed greater than 90% inhibition within 1 and 2 h and a beginning recovery between 4 and 12 h. The only exception was brain, where no effects could be seen after 1 h and where a subsequent decrease to 37% of normal was observed after 12 h.
D000818:Animals; D001812:Blood-Brain Barrier; D004195:Disease Models, Animal; D005776:Gaucher Disease / Q000139:chemically induced*; D005959:Glucosidases / Q000037:antagonists & inhibitors*; D006801:Humans; D007294:Inositol / Q000031:analogs & derivatives* / Q000378:metabolism; D051379:Mice; D014018:Tissue Distribution; D001617:beta-Glucosidase / Q000037:antagonists & inhibitors*
D007294:Inositol; D005959:Glucosidases; D001617:beta-Glucosidase; C011423:conduritol epoxide