Survival from DIC following amniotic fluid embolism. Successful treatment with a serine proteinase inhibitor; FOY.
A 30-year-old multigravida of 38 weeks gestation bled profusely at delivery. Coagulation studies revealed disseminated intravascular coagulation and a diagnosis of amniotic fluid embolism was made. Treatment consisted of transfusion of whole blood and administration of a synthetic serine proteinase inhibitor, FOY. Approximately two hours after administration of the latter, bleeding began to cease and vital signs became stable. The patient survived without sequelae.
D000328:Adult; D001803:Blood Transfusion; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy* / Q000209:etiology; D004619:Embolism, Amniotic Fluid / Q000150:complications*; D005260:Female; D016670:Gabexate; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D007744:Obstetric Labor Complications / Q000188:drug therapy*; D011247:Pregnancy; D011480:Protease Inhibitors / Q000627:therapeutic use*
D006146:Guanidines; D011480:Protease Inhibitors; D016670:Gabexate