title: Autosomal dominant ophthalmologic disorders and linkage.
abstract: A consideration of the currently established autosomal dominant linkage relationships to ophthalmologic disorders was utilized to review the principles of linkage. If cross-over does not occur, as few as 6 informative matings can be utilized to identify probable linkage, and as few as 11 informative matings can be utilized to establish linkage. The potential implications of linkage in diagnosis, prevention, and treatment of heritable disorders was discussed.
mesh_terms: D000135:Acid Phosphatase / Q000235:genetics; D002386:Cataract / Q000235:genetics; D004375:Duffy Blood-Group System / Q000235:genetics; D005128:Eye Diseases / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D006242:Haptoglobins / Q000235:genetics; D006801:Humans; D007498:Iris / Q000002:abnormalities; D008126:Lod Score; D008951:MNSs Blood-Group System / Q000235:genetics; D008297:Male; D010375:Pedigree; D012174:Retinitis Pigmentosa / Q000235:genetics; D012204:Rh-Hr Blood-Group System / Q000235:genetics
chemical_list: D004375:Duffy Blood-Group System; D006242:Haptoglobins; D008951:MNSs Blood-Group System; D012204:Rh-Hr Blood-Group System; D000135:Acid Phosphatase