The xid gene controls Ia.W39-associated immune response gene function.
Immune response (Ir) genes are encoded for by the I region of the major histocompatibility complex (MHC). A class of serologically defined specificities, Ia antigens, is also encoded for by genes within this region. A new Ia specificity, Ia.W39, has recently been defined. It is private for I-Ab and its expression is controlled by a gene on the X-chromosome. Using different approaches, the role of Ia.W39 in the immune response of H-2b mice to beef insulin was examined in a macrophage-dependent T cell proliferation assay. It was found that beef insulin-related Ir gene function was associated with the expression of Ia.W39 by antigen-presenting macrophages and that control of this Ir gene function was X-linked (xid gene).
D000818:Animals; D002417:Cattle; D002455:Cell Division; D005260:Female; D005802:Genes, MHC Class II; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D007328:Insulin / Q000494:pharmacology; D008297:Male; D051379:Mice; D012730:Sex Chromosomes; D013601:T-Lymphocytes / Q000166:cytology; D014960:X Chromosome
D000949:Histocompatibility Antigens Class II; D007328:Insulin