[Pharmacokinetic and clinical evaluation of cefoxitin].
An investigation conducted on healthy volunteers showed that cefoxitin quickly reaches high plasma concentrations, and is almost completely excreted via the urine within 6 hours. In a series of 21 cases treated with 2 g i.v. in 100 ml of a 5% glucose solution two or three times a day, a clinical cure was achieved in 20, and marked improvement in the remaining patient.
D001412:Bacillus subtilis / Q000187:drug effects; D001991:Bronchitis / Q000188:drug therapy; D001996:Bronchopneumonia / Q000188:drug therapy; D002440:Cefoxitin / Q000378:metabolism / Q000627:therapeutic use*; D002761:Cholangitis / Q000188:drug therapy; D003556:Cystitis / Q000188:drug therapy; D004341:Drug Evaluation; D004361:Drug Tolerance; D005738:Gas Gangrene / Q000188:drug therapy; D006562:Herpes Zoster / Q000188:drug therapy; D006801:Humans; D007700:Kinetics; D010019:Osteomyelitis / Q000188:drug therapy; D018805:Sepsis / Q000188:drug therapy
D002440:Cefoxitin
Valutazione farmacocinetica e clinica della cefoxitina.