A system for the continuous collection of 14CO2 from patas monkeys: the metabolism of [14C]cloguanamile.
1. An apparatus is described that allows CO2 expired by monkeys to be trapped and measured and urine and faeces to be separated and collected. 2. When [14C]cloguanamile was administered to rats and to patas monkeys, a marked species difference was seen in the proportion of 14CO2 expired. 3. Suppression of the gut flora by neomycin revealed that this difference was due to enterofloral metabolism.
D000818:Animals; D002245:Carbon Dioxide / Q000032:analysis*; D002250:Carbon Radioisotopes; D004901:Erythrocebus patas; D007422:Intestines / Q000382:microbiology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009355:Neomycin / Q000494:pharmacology; D010671:Phenylurea Compounds / Q000378:metabolism*; D011865:Radioisotope Dilution Technique / Q000295:instrumentation; D051381:Rats
D002250:Carbon Radioisotopes; D010671:Phenylurea Compounds; D002245:Carbon Dioxide; C010089:cloguanamil; D009355:Neomycin