Requirement of macrophage metabolic activity for T-lymphocyte activation.
It has been recently demonstrated that macrophages are necessary accessory cells for T-lymphocyte activation by antigens, mitogens and allogenic cells. This paper shows the function of metabolically inactive macrophages in the activation of T-lymphocytes by phytohemagglutinin (PHA). Macrophages inactivated by mitomycin C are unable to collaborate with T-lymphocytes in the development of the proliferative response to PHA indicating that the role of the macrophage in T-lymphocyte activation by mitogens goes beyond insolubilizing it or rendering it more stimulatory by another passive mechanism.
D000818:Animals; D002478:Cells, Cultured; D008213:Lymphocyte Activation / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects / Q000502:physiology*; D051379:Mice; D008808:Mice, Inbred CBA; D016685:Mitomycin; D008937:Mitomycins / Q000494:pharmacology; D010835:Phytohemagglutinins / Q000494:pharmacology; D013601:T-Lymphocytes / Q000378:metabolism / Q000502:physiology*; D014529:Uridine / Q000378:metabolism
D008937:Mitomycins; D010835:Phytohemagglutinins; D016685:Mitomycin; D014529:Uridine