title: Fragilitas ossium: a new autosomal recessive mutation in the mouse.
abstract: Fragilitas ossium, fro, is an often lethal recessive mutation that was discovered in a randombred stock of mice after treatment with the chemical mutagen tris(1-aziridinyl) phosphine-sulphine. The fro/fro mice have osteoporosis-bending and fracture of the long bones-that is associated with apparently normal cartilage growth. The roentgenological and pathological features are similar to those of the severe, often lethal recessive form of human osteogenesis imperfecta.
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005808:Genes, Recessive; D008297:Male; D051379:Mice; D008817:Mice, Mutant Strains / Q000235:genetics*; D009154:Mutation; D010013:Osteogenesis Imperfecta; D010024:Osteoporosis / Q000235:genetics / Q000662:veterinary*; D012376:Rodent Diseases / Q000235:genetics; D013852:Thiotepa
chemical_list: D013852:Thiotepa