An apparent 1,25-dihydroxyvitamin D-independent stimulation of intestinal calcium absorption in patients with Paget disease of bone during a short-term diphosphonate therapy.
Six patients with Paget disease of bone were treated with a 6-mo course of disodium-ethane-1-hydroxy-1, 1-diphosphate (EHDP) at a dosage of 5 mg/kg/day (one patient) or 20 mg/kg/day (five patients). In addition to symptomatic and biochemical improvement which persisted 3 mo after discontinuance of therapy, EHDP resulted in a significant increase in intestinal calcium absorption that was not correlated with a change in serum 1 alpha, 25-(OH)2-vitamin D concentration. EHDP appears to stimulate intestinal calcium transport by either a vitamin D independent process or by an increased intestinal mucosal cell sensitivity to vitamin D.
D000368:Aged; D000469:Alkaline Phosphatase / Q000097:blood; D002117:Calcitriol; D002118:Calcium / Q000378:metabolism*; D004100:Dihydroxycholecalciferols / Q000097:blood; D012968:Etidronic Acid / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D007408:Intestinal Absorption / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000188:drug therapy* / Q000378:metabolism; D010758:Phosphorus / Q000097:blood
D004100:Dihydroxycholecalciferols; D010758:Phosphorus; D000469:Alkaline Phosphatase; D002117:Calcitriol; D012968:Etidronic Acid; D006909:Hydroxyproline; D002118:Calcium