The effect of fluid deprivation, antidiuretic hormone and forced fluid intake on 51-Cr-EDTA clearance.
The effect of fluid deprivation, antidiuretic hormone (DDAVP) and forced fluid intake on glomerular filtration rate (GFR) was studied in 41 healthy males by determining 51-Cr-EDTA clearance after a single bolus injection. GFR was the same on forced and on free fluid intake. A small, clinically insignificant decrease in GFR (-6.5%), compared to values on free fluid intake, was registered during the periods of fluid deprivation plus DDAVP. There seem to be no objections to combining a clearance study with a concentrating ability test when screening groups of subjects with normal or near normal GFR.
D000328:Adult; D002857:Chromium; D004492:Edetic Acid / Q000378:metabolism*; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D014667:Vasopressins / Q000494:pharmacology*; D014867:Water; D014868:Water Deprivation
D014867:Water; D002857:Chromium; D014667:Vasopressins; D004492:Edetic Acid