Effects of phenoxymethylpenicillin, clindamycin and tinidazole on the anaerobic oral, throat and colon flora in man.
Capsules of phenoxymethylpenicillin were given orally to ten subjects in doses of 800 mg twice daily for 7 days. Saliva, throat and faecal specimens were taken over a 29-day period and bacterial cultivations were carried out. No changes in the normal flora of the saliva, throat or faeces were noted during this period. Clindamycin was given orally to ten other subjects in doses of 150 mg, four times per day for 7 days. No changes in the aerobic flora of the saliva and throat were observed while a significant decrease in the number of anaerobic bacteria occurred. Overgrowth of clostridia was seen in two cases. Pronounced changes in the faecal flora occurred. Among the aerobic bacteria, enterococci proliferated, and among the anaerobic bacteria significant decreases in the numbers of cocci and gram-negative rods were seen. In four subjects the number of clostridia increased significantly. Tinidazole was given orally to ten other subjects in doses of 150 mg every 12 hours for 7 days. Slight changes were noted in the anaerobic flora of the saliva while no differences were seen for the faecal flora.
D000328:Adult; D001419:Bacteria / Q000187:drug effects* / Q000254:growth & development; D002981:Clindamycin / Q000494:pharmacology*; D005232:Fatty Acids, Volatile / Q000378:metabolism; D005243:Feces / Q000382:microbiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009593:Nitroimidazoles / Q000494:pharmacology*; D010404:Penicillin V / Q000494:pharmacology*; D010614:Pharynx / Q000382:microbiology; D012463:Saliva / Q000382:microbiology; D013045:Species Specificity; D014011:Tinidazole / Q000494:pharmacology*
D005232:Fatty Acids, Volatile; D009593:Nitroimidazoles; D014011:Tinidazole; D002981:Clindamycin; D010404:Penicillin V