[State of cellular immunity and phagocytes in guinea pigs infected with Mycoplasma pneumoniae].
The work presents the results of the study of experimental Mycoplasma pneumoniae infection in guinea-pigs. A considerable increase in the engulfment of mycoplasmas and blood leukocytes was found to occur on days 14-28 after the infection. The correlation between the degree of the engulfment of mycoplasmas by macrophages and the activity of lymphocytes in the reaction of blast-cell transformation with phytohemagglutinin and Mycoplasma antigen was observed. The peculiarities of the course of infection in sensitized animals were revealed. Virulent Mycoplasma pneumoniae strains were found to have a toxic effect on the lymphocytes and macrophages of guinea-pigs. This effect was neutralized by specific antiserum. The importance of these facts for the pathogenesis of Mycoplasma infection is discussed.
D000818:Animals; D003168:Complement Fixation Tests; D006168:Guinea Pigs; D006386:Hemagglutination Tests; D007111:Immunity, Cellular; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D008264:Macrophages / Q000276:immunology*; D008297:Male; D009177:Mycoplasma pneumoniae / Q000276:immunology / Q000472:pathogenicity; D010587:Phagocytosis; D011019:Pneumonia, Mycoplasma / Q000276:immunology*; D013045:Species Specificity; D014774:Virulence
Sostoianie kletochnogo immuniteta i fagotsitov pri zarazhenii morskikh svinok Mycoplasma pneumoniae.