[Protective effect of ketotifen and disodium cromoglycate in bronchial challenge tests with allergens (author's transl)].
The protective effect of ketotifen and disodium cromoglycate (DSCG) was evaluated by a randomised double blind cross-over study in 15 children with allergic bronchial asthma. 13 children were allergic to house dust mite (Dermatophagoides pteronyssinus), two to grass pollen. After a positive bronchial challenge test ketotifen or DSCG was given for 4 days followed by bronchial challenge with increasing allergen concentrations. Seven patients showed better allergen tolerance after ketotifen, 5 after DSCG. Protective action against late reactions was found only in 2 children after ketotifen and one child after DSCG.
D000293:Adolescent; D001249:Asthma / Q000188:drug therapy*; D002648:Child; D002986:Clinical Trials as Topic; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D004311:Double-Blind Method; D004391:Dust; D005260:Female; D006801:Humans; D007665:Ketotifen; D008297:Male; D008925:Mites; D010880:Piperidines / Q000627:therapeutic use*; D011058:Pollen; D013876:Thiophenes / Q000627:therapeutic use*
D004391:Dust; D010880:Piperidines; D013876:Thiophenes; D004205:Cromolyn Sodium; D007665:Ketotifen
Schutzwirkung von Ketotifen und Dinatrium cromoglicicum auf die inhalativ provozierte allergogene Bronchialobstruktion.