Autoimmune haemolytic anaemia with monoclonal IgM (kappa) anti-P cold autohaemolysins.
A patient is described with immunoblastic non-Hodgkin's lymphoma and autoimmune haemolytic anaemia of the cold autoantibody type. The autoantibodies were monoclonal IgM-kappa cold haemagglutinins/haemolysins with blood-group specificity, anti-P. Red-cell autoantibodies directed against blood-group-P antigen have until now only been detected, as polyclonal IgG antibodies, in paroxysmal nocturnal haemoglobinuria.
D000373:Agglutinins / Q000032:analysis*; D000744:Anemia, Hemolytic, Autoimmune / Q000150:complications / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis; D001789:Blood Group Antigens / Q000276:immunology*; D003450:Cryoglobulins; D006460:Hemolysin Proteins / Q000032:analysis*; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D008223:Lymphoma / Q000150:complications; D008297:Male; D008875:Middle Aged; D010127:P Blood-Group System / Q000276:immunology*
D000373:Agglutinins; D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D001789:Blood Group Antigens; D003450:Cryoglobulins; D006460:Hemolysin Proteins; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D010127:P Blood-Group System; C029443:cold agglutinins