title: Arachidonic acid metabolism by cultured mesothelial cells. Different transformations of exogenously added and endogenously.
abstract: The capacity of cultured mesothelial cells to produce prostaglandins from both exogenous an endogenous arachidonic acid has been investigated. Incubations with labelled [1-14C]arachidonic acid and [1-14C]prostaglandin endoperoxide H2 indicated the formation of prostacyclin and prostaglandin E2. Evaluation of the transformation of endogenously released arachidonic acid, however, could only confirm the production of prostacyclin.
mesh_terms: D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000378:metabolism*; D002478:Cells, Cultured; D015232:Dinoprostone; D011464:Epoprostenol / Q000096:biosynthesis*; D005978:Glutathione / Q000494:pharmacology; D013058:Mass Spectrometry; D009852:Omentum / Q000378:metabolism*; D011450:Prostaglandin Endoperoxides, Synthetic / Q000378:metabolism; D044262:Prostaglandin H2; D011453:Prostaglandins / Q000096:biosynthesis*; D011458:Prostaglandins E / Q000096:biosynthesis*; D011463:Prostaglandins H / Q000378:metabolism; D011817:Rabbits
chemical_list: D001095:Arachidonic Acids; D011450:Prostaglandin Endoperoxides, Synthetic; D011453:Prostaglandins; D011458:Prostaglandins E; D011463:Prostaglandins H; D016718:Arachidonic Acid; D044262:Prostaglandin H2; D011464:Epoprostenol; D005978:Glutathione; D015232:Dinoprostone