Function of thyroid and hypotalamic-pituitary-thyroid axis in radioiodine treated thyrotoxic patients.
We examined 431 thyrotoxic patients at varying intervals after therapy with radioactive iodine--131I. Recidives of thyrotoxicosis were noted in 30 patients (7%), hypothyroidism in 63 patients (14.4%) and the remaining 338 were euthyroid. A peculiar clinical picture of postradiation hyperthyroidism was ascertained. The euthyroid patients had a lower protein bound iodine (PBI) concentration than normal individuals (4.9 +/- 1.7, resp., 6.0 +/- 1.64 mg/100 ml) and a negative thyroid response after the thyrotrophin-releasing hormone (TRH) stimulation in 87 per cent.
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy* / Q000503:physiopathology; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007037:Hypothyroidism / Q000139:chemically induced; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D013961:Thyroid Gland / Q000503:physiopathology*; D013973:Thyrotropin-Releasing Hormone
D007457:Iodine Radioisotopes; D013973:Thyrotropin-Releasing Hormone