[Effect of a single administration of hydrocortisone within various periods of a day on the incorporation of the labeled precursor into nuclear proteins of intact rat liver].
A single administration of hydrocortisone within various periods of a day led to distinct and dissimilar alterations in distribution of 14C-lysine in erythrocytes, blood plasma and in liver tissue homogenates. The hydrocortisone injection also changed the synthesis of nuclear proteins, especially during the day time. The ability of cell-targets to accept the hormonal signal depended on the functional state of cell chromatin, which is responsible for realization of the signal effect.
D000818:Animals; D002250:Carbon Radioisotopes; D002843:Chromatin / Q000378:metabolism; D002940:Circadian Rhythm; D004912:Erythrocytes / Q000378:metabolism; D006854:Hydrocortisone / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008239:Lysine / Q000378:metabolism; D008297:Male; D009698:Nucleoproteins / Q000096:biosynthesis*; D051381:Rats
D002250:Carbon Radioisotopes; D002843:Chromatin; D009698:Nucleoproteins; D008239:Lysine; D006854:Hydrocortisone
Vliianie gidrokortizona pri ego odnokratnom vvedenii v raznoe vremia sutok na vkliuchenie mechanogo predshestvennika v iadernye belki intaktnoi pecheni krys.