Contraction of guinea pig trachea with antibodies to guinea pig IgE. An in vitro model for asthma.
Rabbit antiserum to guinea pig IgE was prepared. This antiserum absorbed IgE antibodies to dinitrophenyl determinants when examined by passive cutaneous anaphylaxis. This antiserum also provoked contraction of tracheal rings from normal guinea pigs in vitro. This system is a new model for asthma in which only IgE among immunoglobulins reacts.
D000818:Animals; D000906:Antibodies; D001249:Asthma / Q000276:immunology*; D005591:Chemical Fractionation; D004136:Dinitrobenzenes / Q000276:immunology; D004195:Disease Models, Animal; D006168:Guinea Pigs; D005779:Immunodiffusion; D007073:Immunoglobulin E / Q000276:immunology*; D009119:Muscle Contraction; D009559:Nippostrongylus / Q000276:immunology; D010047:Ovalbumin / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis; D011817:Rabbits; D014132:Trachea / Q000503:physiopathology*
D000906:Antibodies; D004136:Dinitrobenzenes; D007073:Immunoglobulin E; D010047:Ovalbumin