Impaired dopaminergic control of thyroid stimulating hormone secretion in chronic renal failure.
After administration of intravenous metoclopramide, a dopaminergic receptor blocking agent, no rise in thyroid stimulating hormone (TSH) could be found in patients with chronic renal failure, in contrast to non-uraemic controls. Basal TSH values were normal in the uraemic patients but the TSH response to thyrotrophin-releasing hormone (TRH) was significantly reduced. These results suggest that a discrete abnormality in the hypothalamo-pituitary axis exists in uraemia which may in part be due to interference with central dopaminergic control by a uraemic toxin.
D000328:Adult; D005260:Female; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D007676:Kidney Failure, Chronic / Q000097:blood / Q000503:physiopathology*; D008297:Male; D008787:Metoclopramide; D008875:Middle Aged; D013972:Thyrotropin / Q000097:blood / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone; D014511:Uremia / Q000097:blood / Q000503:physiopathology
D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D008787:Metoclopramide