[Immunologic deficiency linked to aging. Role of monocytes].
The capacity of mononuclear cells from individuals over 70 years of age to mount a primary in vitro antibody response is profoundly decreased. We show that the removal of a nylon-adherent cell restores this response. The suppressor cell is plastic adherent, phagocytic non-T and radio-resistant, thus probably a monocyte. Its effect is inhibited by indomethacin, which suggests that its action if mediated by prostaglandins.
D000328:Adult; D000368:Aged; D000375:Aging; D006801:Humans; D007109:Immunity; D007213:Indomethacin / Q000494:pharmacology; D009000:Monocytes / Q000276:immunology*; D011453:Prostaglandins / Q000276:immunology / Q000502:physiology
D011453:Prostaglandins; D007213:Indomethacin
Déficit immunitaire lié au vieillissement. Rôle des monocytes.