Disoprofol and fentanyl for total intravenous anaesthesia.
Ninety patients undergoing a variety of surgical procedures were anaesthetised with a disoprofol infusion and increments of fentanyl. The first 40 patients constituted a preliminary dose finding study and the subsequent 50 patients a dose comparison study. The second 50 patients were alternately allocated to receive a maintenance infusion of disoprofol 150 or 200 micrograms/kg/minute. Fentanyl (1 microgram/kg) at induction was followed by further small increments when indicated. Maintenance dosage of 200 micrograms/kg/minute provided good operating conditions and rapid uncomplicated recovery in spontaneously breathing patients, while 150 micrograms/kg/minute proved inadequate to prevent patient movement.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000771:Anesthesia, Intravenous; D000777:Anesthetics / Q000008:administration & dosage; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D004334:Drug Administration Schedule; D005260:Female; D005283:Fentanyl; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D010313:Partial Pressure; D010636:Phenols / Q000008:administration & dosage; D015742:Propofol; D013997:Time Factors
D000777:Anesthetics; D010636:Phenols; D002245:Carbon Dioxide; D005283:Fentanyl; D015742:Propofol