title: [Microsomal oxidation system in the course of development and aging].
abstract: No substantial differences in the oxidoreductase activity of the NADH-driven electron transfer chain components in the course of development and ageing of Wistar rats aged 1, 3, 12 and 24 months were found. The content or activity of separate links of the NADPH-driven chain reached their maximal values at different age periods, being decreased with ageing. The demethylase and hydroxylase activities remained unchanged upon ageing. The ratio of the NADPH-cytochrome c reductase activity to cytochrome P-450 content was decreased in 1-, 3- and 12-months-old animals.
mesh_terms: D000375:Aging; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004579:Electron Transport; D008099:Liver / Q000254:growth & development*; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009243:NAD / Q000378:metabolism*; D009249:NADP / Q000378:metabolism*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D010084:Oxidation-Reduction; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism*; D051381:Rats
chemical_list: D009243:NAD; D009249:NADP; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D010089:Oxidoreductases, N-Demethylating; D009251:NADPH-Ferrihemoprotein Reductase
vernacular_title: Sistema mikrosomal'nogo okisleniia pri razvitii i starenii organizma.