[Calmodulin regulation of intestinal epithelium adenylate cyclase (author's transl)].
Calmodulin stimulation of intestinal adenylate cyclase was evidenced in plasma membranes from isolated Rat intestinal epithelial cells. In the presence of free calcium, 10(-7) M calmodulin significantly stimulates intestinal enzyme activity and the maximal effect is induced by 10(-5) M calmodulin. Trifluoperazine, a specific calmodulin inhibitor suppresses this effect. These results suggest that calcium, via calmodulin, plays an important role in the regulation of cyclic AMP production in intestinal epithelium.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D002135:Calcium-Binding Proteins / Q000494:pharmacology*; D002147:Calmodulin / Q000494:pharmacology*; D004848:Epithelium / Q000201:enzymology; D007421:Intestine, Small / Q000201:enzymology*; D007700:Kinetics; D051381:Rats; D014268:Trifluoperazine / Q000494:pharmacology
D002135:Calcium-Binding Proteins; D002147:Calmodulin; D014268:Trifluoperazine; D000262:Adenylyl Cyclases; D002118:Calcium
Régulation par la calmoduline de l'activité adenylate cyclasique de l'épithélium intestinal.