Evidence for the role of androgens in the feedback control of gonadotrophin secretion in the human female.
The effect of androgens on the luteinizing hormone (LH) response to LH-releasing hormone (LH-RH) is fairly well documented. However, the evidence concerning the effect on follicle-stimulating hormone (FSH) is less convincing and clear-cut. We administered LH-RH to a patient with an androgen-producing adrenal tumour both before and after removal of the tumour. Before operation, testosterone levels were elevated and oestradiol levels reduced. There was no response of either LH or FSH levels to LH-RH on two separate occasions. Postoperatively LH and FSH values rose sharply, to 404% and 170% above basal levels respectively. The data suggest that androgens do play a role in the feedback control of both LH and FSH secretion.
D000310:Adrenal Gland Neoplasms / Q000378:metabolism; D000328:Adult; D002277:Carcinoma / Q000378:metabolism; D005246:Feedback; D005260:Female; D005640:Follicle Stimulating Hormone / Q000378:metabolism*; D007987:Gonadotropin-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D007986:Luteinizing Hormone / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism*
D007987:Gonadotropin-Releasing Hormone; D013739:Testosterone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone