[Influence of clonazepam on interictal penicillin-spikes (author's transl)].
This paper deals with the action of Clonazepam on Penicillin induced interictal discharges. In 7 rabbits Penicillin was applied epicortically in a concentration of 25,000 or 50,000 I.U. The intracortical recordings were made with an 8 fold electrode, made by thin-film technology. Clonazepam (0.5 or 1.0 mg/kg) was given intravenously 30 to 45 min after the Penicillin application. Under Clonazepam the occurrence of double-und multiple interictal discharge is abolished. Single spikes become shorter and are significantly reduced in amplitude. Current Source-Density analysis showed that the configuration of sources and sinks is not altered under the action of this drug. However the spatio-temporal distribution is reduced drastically. If the shape of interictal spikes is compared by means of averaging technique before and after the application of Clonazepam, one observes a significant decrease in the standard deviation. These results indicate that excitatory processes are reduced by an enhancement of inhibitory phenomena within the cerebral cortex.
D000818:Animals; D001570:Benzodiazepinones / Q000627:therapeutic use*; D002540:Cerebral Cortex / Q000187:drug effects; D002998:Clonazepam / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D010400:Penicillin G / Q000633:toxicity*; D011817:Rabbits; D012640:Seizures / Q000139:chemically induced*
D001570:Benzodiazepinones; D002998:Clonazepam; D010400:Penicillin G
Die Beeinflussung von interiktalen Penicillin-spitzen durch Clonazepam.