Thyrotropin-releasing hormone improves cardiovascular function in experimental endotoxic and hemorrhagic shock.
Thyrotropin-releasing hormone significantly improved cardiovascular function when it was injected intravenously into conscious rats subjected to experimental endotoxic or hemorrhagic shock. Because thyrotropin-releasing hormone appears to be a "physiologic: opiate antagonist without effects on pain responsiveness, it may provide therapeutic benefits in the treatment of shock or acute hypotension.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004195:Disease Models, Animal; D004731:Endotoxins; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D051381:Rats; D012771:Shock, Hemorrhagic / Q000503:physiopathology*; D012772:Shock, Septic / Q000503:physiopathology*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D004731:Endotoxins; D013973:Thyrotropin-Releasing Hormone