title: Metabolism of bis(2-chloroethyl)ether and bis(2-chloroisopropyl)ether in the rat.
abstract: Male rats were given single peroral doses of bis(1-14C-2-chloroethyl)ether ([1-14C]BCEE) (40 mg/kg) and of bis(1-14C-2-chloroisopropyl)ether ([1-14C]BCIE) (90 mg/kg). Excretion of 14CO2 and urinary 14C was followed for 48 hr. The time required to eliminate one half of the dose was 12 hr for [1-14C]BCEE and 19 hr for [1-14C]BCIE. In the case of [1-14C]BCEE, expired 14CO2 accounted for 11.5 +/- 5.6(SD)% of the dose, urinary 14C accounted for 64.7 +/- 14.8%, and 2.4 +/- 1.3% was found in the feces. The figures for [1-14C]BCIE were 20.3 +/- 9.4% expired as 14CO2, 47.5 +/- 8.1% as urinary 14C, and 3.8 +/- 0.3% as fecal 14C. Thiodiglycolic acid (TDGA) accounted for roughly 75% of the total urinary 14C collected after the [1-14C]BCEE dose. Lesser metabolites of BCEE were 2-chloroethoxyacetic acid (CEAA) (5%), and N-acetyl-S-[2-(2-chloroethoxy)ethyl]-L-cysteine (ACEEC) (7%). Metabolites of [1-14C]BCIE identified in rat urine were 2-(2-chloro-1-methylethoxy)propanoic acid (CMEPA), roughly 36% of the total urinary 14C, and N-acetyl-S-(2-hydroxypropyl)-L-cysteine (AHPC) at 19%.
mesh_terms: D000818:Animals; D001711:Biotransformation; D002245:Carbon Dioxide / Q000378:metabolism; D004986:Ether / Q000031:analogs & derivatives / Q000378:metabolism*; D004987:Ethers / Q000378:metabolism*; D005019:Ethyl Ethers / Q000378:metabolism*; D005243:Feces / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D051381:Rats; D011919:Rats, Inbred Strains; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D004987:Ethers; D005019:Ethyl Ethers; D004986:Ether; D002245:Carbon Dioxide; C017830:bis(2-chloroisopropyl)ether; C006767:bis(2-chloroethyl)ether