The influence of some cinnamic acid derivatives on cyclo-oxygenase and lipoxidase activities.
Seven derivatives of cinnamic acid containing hydroxyl group in phenyl ring were found to stimulate cyclo-oxygenase from ram seminal vesicle microsomes and to inhibit lipoxidases from soybean and from horse blood platelets. Certain degree of negative correlation (r=-0,7) was found between the activities of both enzymes.
D000818:Animals; D002934:Cinnamates / Q000494:pharmacology*; D066298:In Vitro Techniques; D007679:Kidney Medulla / Q000201:enzymology; D008084:Lipoxygenase / Q000378:metabolism*; D008297:Male; D008861:Microsomes / Q000201:enzymology; D010101:Oxygen Consumption / Q000187:drug effects; D010974:Platelet Aggregation / Q000187:drug effects; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D012756:Sheep; D013268:Stimulation, Chemical
D002934:Cinnamates; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases