Effect of changes in serum calcium on secretin-stimulated serum gastrin in patients with Zollinger-Ellison syndrome.
This study was undertaken to determine whether or not the serum gastrin response to secretin in patients with Zollinger-Ellison syndrome is influenced by changes in serum calcium. After infusion of 50 mg/kg disodium ethylenediaminetetraacetate over 90 min in 7 patients with Zollinger-Ellison syndrome, increases in serum gastrin following administration of 1 CU/kg (Cu-clinical unit) secretin GIH (118 +/- 46 pg/ml) were lower than the response before the infusion (755 +/- 90 pg/ml; p less than 0.01). Before infusion of disodium ethylenediaminetetraacetate all 7 patients with Zollinger-Ellison syndrome had gastrin increases after secretin administration above 100 pg/ml, while after the infusion 4 of 7 patients had secretin-stimulated increases in serum gastrin below 100 pg/ml. Subsequent normalization of serum calcium by infusion of 3 mg/kg calcium over 15 min resulted in gastrin responses to secretin of greater than 100 pg/ml. Infusion of 10 mg/kg calcium over 120 min in 4 Zollinger-Ellison syndrome patients induced significant increases in secretin-stimulated serum gastrin from 660 +/- 180 to 1339 +/- 286 pg/ml (p = 0.005). This dose of calcium did not increase the gastrin response to secretin in 5 normogastrinemic and 2 hypergastrinemic control subjects. It was concluded that serum gastrin response to secretin in patient with Zollinger-Ellison syndrome is influenced by serum calcium concentrations.
D000328:Adult; D002118:Calcium / Q000008:administration & dosage / Q000097:blood*; D004492:Edetic Acid / Q000008:administration & dosage; D005260:Female; D005755:Gastrins / Q000097:blood*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D012633:Secretin / Q000494:pharmacology*; D015043:Zollinger-Ellison Syndrome / Q000097:blood*
D005755:Gastrins; D012633:Secretin; D004492:Edetic Acid; D002118:Calcium