title: Distribution of protein I, a synapse-specific phosphoprotein, and adenylate cyclase in the rat spinal cord.
abstract: The longitudinal and transverse distributions of the synapse-specific phosphoprotein Protein I and adenylate cyclase in the rat spinal cord were studied. Protein I was found to be enriched in all cervical and midlumbar (L3-L5) segments, and sparse in midthoracic and sacral segments. Adenylate cyclase activity was high in all cervical and lumbosacral segments, and low in mid-thoracic segments. Cross sectionally, both Protein I and adenylate cyclase were more enriched in the dorsal half than in the ventral half in the various segments studied. The similar topographical distributions of Protein I and adenylate cyclase in the spinal cord support the idea that adenylate cyclase may be intimately associated with Protein I in the nervous system, and could thereby regulate the state of in vivo phosphorylation of Protein I through formation of cyclic AMP.
mesh_terms: D000262:Adenylyl Cyclases / Q000032:analysis*; D000818:Animals; D009419:Nerve Tissue Proteins / Q000032:analysis*; D010750:Phosphoproteins / Q000032:analysis*; D051381:Rats; D013116:Spinal Cord / Q000032:analysis*; D013127:Spinal Nerves; D013569:Synapses / Q000378:metabolism; D016704:Synapsins
chemical_list: D009419:Nerve Tissue Proteins; D010750:Phosphoproteins; D016704:Synapsins; D000262:Adenylyl Cyclases