title: Vagotomy reverses apnea induced by high-frequency oscillatory ventilation.
abstract: Apnea has been observed in both animals and patients during high-frequency oscillatory ventilation. The effects of vagotomy were studied during periods of oscillator-induced apnea in 11 pentobarbital-anesthetized dogs. The animals were intubated and breathing spontaneously. An arterial cannula was inserted for monitoring blood pressure and blood gases. Intratracheal airway pressure was measured, and respiratory activity was assessed using either an intrapleural catheter or esophageal balloon. The dogs then underwent high-frequency ventilation at 15 Hz. Apnea was induced by appropriate selection of volume displacement of the piston pump and the distal airway pressure in eucapnic animals. Segments of right and left vagus nerves were exposed in the neck, bathed in local anesthetic, and transected. Spontaneous ventilation resumed immediately in nine animals and could not be suppressed at the same CO2 partial pressure despite continuation of oscillation. We conclude that the apnea observed during high-frequency ventilation is mediated by active vagal inhibition of central respiratory activity and is usually reversed by vagotomy.
mesh_terms: D000818:Animals; D001049:Apnea / Q000503:physiopathology*; D002245:Carbon Dioxide / Q000097:blood; D004285:Dogs; D004947:Esophagus / Q000502:physiology; D005740:Gases / Q000097:blood; D006863:Hydrogen-Ion Concentration; D010100:Oxygen / Q000097:blood; D012121:Respiration, Artificial; D014628:Vagotomy
chemical_list: D005740:Gases; D002245:Carbon Dioxide; D010100:Oxygen