Immunologic studies of factor VIII coagulant activity (VIII:C). 2. Factor VIII in selected vertebrates.
Cross reactive antigens to factor VIII have been measured in a range of vertebrate phyla. VIII coagulant antigen (VIII:CAg) measured using a human antibody was in general, much lower than reported values of VIII coagulant activity (VIII:C) except in simians and the guinea pig. The dose response curve for the assay was parallel in all cases. Factor VIII-related antigen (VIIIR:Ag) measured using rabbit antibody to human VIIIR:Ag was low or absent in most species except simians and the dose response curve was non-parallel to the human standard except with goat plasma. Avians lacked cross-reactive material.
D000818:Animals; D000941:Antigens; D002335:Carnivora; D002415:Cats; D002417:Cattle; D002645:Chickens; D003429:Cross Reactions; D004285:Dogs; D004306:Dose-Response Relationship, Immunologic; D005169:Factor VIII / Q000276:immunology*; D006041:Goats; D006071:Gorilla gorilla; D006168:Guinea Pigs; D006801:Humans; D008251:Macaca; D010215:Papio; D010527:Perissodactyla; D011817:Rabbits; D051381:Rats; D046048:Seals, Earless; D012756:Sheep; D013552:Swine; D014422:Turkeys; D014841:von Willebrand Factor
D000941:Antigens; D014841:von Willebrand Factor; D005169:Factor VIII