Urinary granulopoietic activity in chronic myelogenous leukemia: follow-up and correlation with various phases of the disease.
Daily urinary colony-stimulating factor (CSF) output was tested in 16 patients with chronic myeloid leukemia, 12 of which were in stable phase and 4 in blast crisis of the disease. The CSF of stable-phase patients varied within normal range, while all patients in blast crisis had values lower than normal. Also the number of CFUC ranged within normal values in stable-phase patients, while no colony growth was detectable in blast-crisis patients. Sequential studies (28 or 11 months) of 2 patients revealed an inverse relation between daily urinary CSF and presence of peripheral immature or blast cells in the patient in stable or blast phase, respectively.
D000328:Adult; D001853:Bone Marrow; D003114:Colony-Forming Units Assay; D003115:Colony-Stimulating Factors / Q000097:blood / Q000652:urine*; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood / Q000188:drug therapy / Q000652:urine*; D008875:Middle Aged
D003115:Colony-Stimulating Factors