Comparative pharmacokinetic studies on dogs following systemic and intraportal gentamycin infusion.
Our results, which confirmed on the basis of our experiment that Gentamycin in the bile is extracted by the liver only after prolonged systemic infusion and only in low concentration, contrasted with intraportal infusion of the drug resulting in doses above MIC level after 30 minutes and the difference is highly significant after 60 minutes.
D000818:Animals; D001412:Bacillus subtilis / Q000187:drug effects; D001646:Bile / Q000378:metabolism*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000378:metabolism*; D007263:Infusions, Parenteral; D008099:Liver / Q000378:metabolism; D008297:Male; D008826:Microbial Sensitivity Tests; D011169:Portal Vein
D005839:Gentamicins