Effect of topical application of amino acids on gastric pepsin secretion in the rat. Part III: effect of L- and D-isomers of amino acids on gastric secretion in reperfusion system.
This study was undertaken to compare the potency of each L- and D-isomers of 5 amino acids in stimulating gastric acid and pepsin secretion by the intragastric reperfusion preparation in rats. Gastric basal and glycine-stimulated secretions in this preparation were lower than those Ghosh-Lai preparation, but not to a statistically significant extent. All D- and L-isomers of amino acids tested were found to markedly stimulate pepsin secretion, but to only slightly stimulate acid secretion. Pepsin stimulatory response to each D and L-isomer of amino acid was similar. The stimulatory effects of amino acids thus seem to be unrelated to the optical stereoisomeric configuration.
D000287:Administration, Topical; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D010434:Pepsin A / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D011919:Rats, Inbred Strains; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000596:Amino Acids; D010434:Pepsin A