Nonprogressive course of non-A, non-B chronic hepatitis in multitransfused hemophiliacs.
Eleven hemophiliacs with chronic liver disease were studied prospectively for 6 yr, with liver function tests and liver biopsies carried out at intervals of 3 yr. The second series of biopsies, compared with the first series, showed continuation of chronic persistent hepatitis in four patients, change to chronic lobular hepatitis in two, and spontaneous improvement of the disease in the four cases who had had chronic active hepatitis characterized by moderate piecemeal necrosis. One patient with active cirrhosis died of liver failure during the follow-up period. Study of the serum and intrahepatic markers for hepatitis B and delta viruses suggests that chronic liver disease is nonprogressive in hemophiliacs who have no intrahepatic viral marker.
D000293:Adolescent; D000328:Adult; D001219:Aspartate Aminotransferases / Q000097:blood; D002648:Child; D002908:Chronic Disease; D005164:Factor IX / Q000009:adverse effects / Q000627:therapeutic use; D005169:Factor VIII / Q000009:adverse effects / Q000627:therapeutic use; D005500:Follow-Up Studies; D006467:Hemophilia A / Q000150:complications* / Q000628:therapy; D002836:Hemophilia B / Q000150:complications* / Q000628:therapy; D006526:Hepatitis C / Q000188:drug therapy / Q000209:etiology* / Q000276:immunology; D006525:Hepatitis, Viral, Human / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D065227:Transfusion Reaction
D005169:Factor VIII; D005164:Factor IX; D001219:Aspartate Aminotransferases; D011241:Prednisone