Studies on new vasodilators, WS-1228 A and B. I. Discovery, taxonomy, isolation and characterization.
New vasodilators, designated WS-1228 A and B have been discovered in the culture filtrate of a strain of Streptomyces aureofaciens. The active compounds were purified by column chromatography with Diaion HP-20 and silica gel, and finally separated from each other by high performance liquid chromatography. They were obtained as pale yellow crystals and their molecular formulae were both C11H17N3O.
D000818:Animals; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D013302:Streptomyces / Q000145:classification; D013304:Streptomyces aureofaciens / Q000378:metabolism*; D014226:Triazenes / Q000138:chemical synthesis*; D014665:Vasodilator Agents / Q000302:isolation & purification* / Q000494:pharmacology
D014226:Triazenes; D014665:Vasodilator Agents; C034613:triacsin C; C034614:triacsin D