Food intake following systemic 6-hydroxydopamine injection.
Food intakes of intact and adreno-demedullated rats acclimated at 5 degree C or 23 degree C for 5 weeks were examined for a period of 7 days following i.p. treatment of 6-hydroxydopamine (6-OHDA). Controls were treated with acidified saline. All 6-OHDA rats had significant (P less than 0.01) reduction in food intake on the day following treatment. Food intake of cold-acclimated rats returned to the level of control rats on day 3 while that of non-cold-acclimated did not until day 7. A general malaise resulting from severe cardiovascular hypotension was suggested as the cause of reduction, and the requisite drive for energy sources attenuated the reduction in food intake subsequent to 6-OHDA administration.
D000064:Acclimatization; D000313:Adrenal Medulla / Q000502:physiology; D000818:Animals; D003080:Cold Temperature; D004435:Eating / Q000187:drug effects*; D006892:Hydroxydopamines / Q000494:pharmacology*; D007022:Hypotension / Q000150:complications; D007274:Injections, Intraperitoneal; D008297:Male; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013312:Stress, Physiological; D013997:Time Factors
D006892:Hydroxydopamines; D016627:Oxidopamine