title: Disinfecting endoscopes: how not to transmit Mycobacterium tuberculosis by bronchoscopy.
abstract: Mycobacterium tuberculosis was cultured from the bronchial washings of two patients who underwent bronchoscopy consecutively with the same bronchoscope. Active pulmonary tuberculosis was later confirmed in the first patient, whereas the second patient had clinical and serologic evidence of infection with respiratory syncytial virus. The bronchoscope had been cleaned with an iodophor disinfectant, which had not destroyed the tubercle bacilli. The agent recommended for chemical disinfection of fibreoptic bronchoscopes is 2% glutaraldehyde solution; the instrument should be immersed in it for 10 to 30 minutes. Five hours' exposure to ethylene oxide is recommended for sterilization of instruments. These procedures must be preceded by adequate mechanical cleaning. Then transmission of pathogenic organisms during endoscopy, which can result in nosocomial disease, misdiagnosis or inappropriate treatment, will be avoided.
mesh_terms: D000328:Adult; D001999:Bronchoscopy / Q000009:adverse effects*; D004203:Disinfection / Q000379:methods*; D005027:Ethylene Oxide / Q000494:pharmacology; D005069:Evaluation Studies as Topic; D005260:Female; D005336:Fiber Optic Technology; D005976:Glutaral / Q000494:pharmacology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013242:Sterilization / Q000379:methods*; D013525:Surgical Instruments; D014397:Tuberculosis, Pulmonary / Q000635:transmission*
chemical_list: D005027:Ethylene Oxide; D005976:Glutaral