Lipid peroxidation in iron-overloaded spleens.
1. Iron-overloaded spleens from thalassaemic subjects showed a greatly increased susceptibility to free-radical oxidation (peroxidation) in vitro. 2. Iron content was the main but not the only variable governing susceptibility. Added ascorbate had a dose-dependent action either as an antioxidant or as a pro-oxidant, the direction of its effect depending mainly on the degree of iron overload. This has therapeutic implications.
D000293:Adolescent; D001205:Ascorbic Acid / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D004492:Edetic Acid / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007501:Iron / Q000378:metabolism*; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D013154:Spleen / Q000378:metabolism*; D013789:Thalassemia / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism
D008054:Lipid Peroxides; D014810:Vitamin E; D004492:Edetic Acid; D007501:Iron; D001205:Ascorbic Acid