[Pharmacotherapy during pregnancy. Teratological aspects (author's transl)].
Accidental pharmacotherapy in unrecognized pregnancy gives occasion for human genetic counseling to an increasing extent. In this, it must be clarified to what stage of development a drug was administered, whether a teratogenic effect is to be assumed, how long the effect lasts and whether compensation is possible for the damage which has occurred. Furthermore, genetic and non-genetic induced differences in the uptake, metabolization and excretion of drugs and the extent of the genetically induced sensitivity in special areas of the organ anlage in the embryo must be taken into account in the counseling.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D004359:Drug Therapy, Combination; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange / Q000187:drug effects; D008657:Metabolic Clearance Rate; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D012306:Risk
Pharmakotherapie in der Schwangerschaft. Teratologische Aspekte.