Studies of the influence of nitroglycerin on the synthesis of prostaglandins and thromboxane A2 and on platelet aggregation.
Nitroglycerin (NG) did not influence the synthesis of prostaglandins and thromboxanes in organs and microsomal fractions of various animal species (rat, pig, rabbit). NG is an inhibitor of platelet aggregation in vitro dependent on NG dose and platelet activator. NG is able to disaggregate ADP-induced platelet aggregation. An increased antiaggregatory effect was observed when a low concentration of PGI2 was combined with NG.
D000818:Animals; D011464:Epoprostenol / Q000378:metabolism; D008315:Malondialdehyde / Q000378:metabolism; D005996:Nitroglycerin / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D011453:Prostaglandins / Q000096:biosynthesis*; D011463:Prostaglandins H / Q000378:metabolism; D011817:Rabbits; D051381:Rats; D013552:Swine; D013928:Thromboxane A2 / Q000096:biosynthesis*; D013929:Thromboxane B2 / Q000378:metabolism; D013931:Thromboxanes / Q000096:biosynthesis*
D011453:Prostaglandins; D011463:Prostaglandins H; D013931:Thromboxanes; D008315:Malondialdehyde; D013929:Thromboxane B2; D013928:Thromboxane A2; D011464:Epoprostenol; D005996:Nitroglycerin