title: Effects of duodenal perfusion with sodium taurocholate on biliary and pancreatic secretion in man.
abstract: The effects of intraluminal sodium taurocholate (STC) on biliary and pancreatic secretion were studied in man using a duodenal perfusion technique and indocyanine green (ICG) as an exogenous biliary marker. Duodenal perfusion with 15 or 30 mmol/l STC in healthy subjects markedly suppressed caerulein and secretin stimulated biliary indocyanine green (ICG) excretion in a dose responsive manner, i.e. to 40% (17-95%, +/- 2 SD, n = 5) (P less than 0.025) and 32% (26-38%, +/- 2 SD, n = 3) (P less than 0.003) of i.v. ICG infusion, respectively, with a maximum suppression to 26% and 10%, respectively. In cholecystectomized subjects (n = 5), significant changes in ICG excretion were not observed during STC (15 mmol/l) perfusion. There were no suppressive effects on pancreatic enzyme or bicarbonate secretion in any of the subjects. Our observations suggest that the bile salts STC in the duodenum in man activated a mechanism which selectively suppressed biliary excretion. This is probably due to relaxation of the gallbladder and an increase in gallbladder storage of bile.
mesh_terms: D000328:Adult; D001639:Bicarbonates / Q000378:metabolism; D001646:Bile / Q000378:metabolism*; D002108:Ceruletide / Q000378:metabolism; D002763:Cholecystectomy; D004386:Duodenum / Q000502:physiology* / Q000503:physiopathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007208:Indocyanine Green / Q000494:pharmacology; D008875:Middle Aged; D010179:Pancreas / Q000378:metabolism*; D010477:Perfusion; D012633:Secretin / Q000378:metabolism; D013656:Taurocholic Acid / Q000494:pharmacology; D014357:Trypsin / Q000378:metabolism
chemical_list: D001639:Bicarbonates; D012633:Secretin; D013656:Taurocholic Acid; D002108:Ceruletide; D014357:Trypsin; D007208:Indocyanine Green