Aminoglycoside ototoxicity in the neonatal period: possible etiologic factor delayed postural control.
Forty-three infants, treated with aminoglycosides during the neonatal period, were tested repeatedly over a period of two to five years for neurovestibular responses. Results of testing were compared with those obtained from a group of 276 healthy newborns followed simultaneously. No abnormalities were found in the untreated group. Among the treated infants, three had a sensorineural hearing loss and eight had laboratory evidence of vestibular dysfunction and delay of head and postural control.
D000617:Aminoglycosides / Q000009:adverse effects* / Q000627:therapeutic use; D002675:Child, Preschool; D003051:Cochlea / Q000187:drug effects*; D005500:Follow-Up Studies; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000188:drug therapy*; D011187:Posture; D018805:Sepsis / Q000188:drug therapy*; D014724:Vestibular Function Tests; D014722:Vestibule, Labyrinth / Q000187:drug effects*
D000617:Aminoglycosides