Genetic control of cross-reactive cytotoxic T-lymphocyte responses to a BALB/c tumor.
Using a segregation analysis we have determined that the cross-reactive response to the DBA/2 tumor P815 by CTL from BALB/c mice immunized with a BALB/c plasmacytoma (MOPC-167) is controlled by a single gene. The gene responsible is closely linked to the dilute coat color locus on chromosome 9. In contrast, the cross-reactive response to the DBA/2 tumor L5178Y by DBA/2 anti-MOPC-167 CTL appears to be controlled by two or more genes.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000235:genetics*; D003429:Cross Reactions; D005796:Genes; D005802:Genes, MHC Class II; D008040:Genetic Linkage; D006200:Hair Color; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics; D008811:Mice, Inbred DBA / Q000235:genetics; D009374:Neoplasms, Experimental / Q000276:immunology*; D010641:Phenotype; D010954:Plasmacytoma / Q000276:immunology*
D000912:Antibodies, Neoplasm