The effect of chlorpromazine on transformation in Bacillus subtilis.
In the presence of the widely used tranquilizer, chlorpromazine, transforming DNA of Bacillus subtilis is photoinactivated by long-wave ultraviolet light. The loss of biological activity is predominantly caused by lack of binding of the DNA to recipient cells and the introduction of single-strand breaks in the treated DNA.
D001412:Bacillus subtilis / Q000235:genetics*; D002499:Centrifugation, Density Gradient; D002746:Chlorpromazine / Q000494:pharmacology*; D004269:DNA, Bacterial / Q000528:radiation effects; D004587:Electrophoresis, Agar Gel; D008970:Molecular Weight; D013997:Time Factors; D014170:Transformation, Genetic / Q000187:drug effects; D014466:Ultraviolet Rays
D004269:DNA, Bacterial; D002746:Chlorpromazine