Inhibitory effect of human urinary extract on the growth of DMBA-induced mammary tumors in Holtzman rat.
The effect of a crude protein fraction from human urine having gonadotropin inhibitory activity (GGIM) was observed on the growth of 7,12-dimethylbenz(a)anthracene induced mammary tumors in Holtzman rat. Results show that while in 12 out 13 tumors, tumor growth was retarded/regressed following 2--4 weeks of CGIM treatment, tumor growth in control rats was unabated. However, no positive correlation with hormone dependency and tumor regression could be established. Further, this crude anti LH material was found to be non-toxic to tumor cells in vitro.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D005260:Female; D006062:Gonadotropins / Q000037:antagonists & inhibitors*; D006801:Humans; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D010455:Peptides / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains
D006062:Gonadotropins; D010455:Peptides; D015127:9,10-Dimethyl-1,2-benzanthracene