title: The alcohol facilitation effect on memory: a dose-response study.
abstract: Sixteen normal male subjects participated in four sessions where they studied a set of pictures followed by either placebo, 0.025, 0.50, or 1.0 ml/kg alcohol. Later, when sober, recognition memory was tested. These doses resulted in peak blood alcohol concentrations (BAC) of 0.00, 0.018, 0.034, and 0.067 g/100 ml, respectively. The 1.0 and 0.50 ml/kg doses significantly improved memory for pictures studied before drinking. Alcohol appears to enhance memory directly rather than indirectly via a reduction in interference. It is suggested that a particular phase of the rising blood alcohol curve (0.02-0.03 g/100 ml) facilitates trace consolidation. The facilitating and possibly excitatory effects of alcohol may be important for understanding the rewarding aspects of drinking.
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D008568:Memory / Q000187:drug effects*
chemical_list: D000431:Ethanol