title: Antitumor activity of Lactobacillus casei in mice.
abstract: The effect of Lactobacillus casei YIT 9018 (LC 9018) on the growth of transplantable allogeneic and syngeneic mouse tumors was studied. Intraperitoneal treatment of LC 9018 caused a significant prolongation of the life span of ICR mice inoculated with sarcoma-180 intraperitoneally and BDF1 mice inoculated with L1210 leukemia intraperitoneally. Intravenous injection of LC 9018 markedly inhibited the growth of subcutaneously inoculated sarcoma-180. This organism was also effective against methylcholanthrene-induced syngeneic MCA K-1 tumor in BALB/c mice. The antitumor activity of LC 9018 was reduced by treatment with carrageenan, an anti-macrophage agent, and was also observed in T-cell deficient athymic nude mice. These results suggested that the antitumor activity of LC 9018 may be macrophage-dependent.
mesh_terms: D000818:Animals; D002351:Carrageenan / Q000627:therapeutic use; D002460:Cell Line; D004336:Drug Antagonism; D007780:Lacticaseibacillus casei; D007939:Leukemia L1210 / Q000628:therapy*; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000139:chemically induced; D012510:Sarcoma 180 / Q000628:therapy*; D013601:T-Lymphocytes / Q000276:immunology
chemical_list: D008748:Methylcholanthrene; D002351:Carrageenan