[Comparative study of the mutagenic activity of organophosphate insecticides on bacteria].
Mutagenic activity of the organo-phosphorus insecticides, metaphos, phosphamide and carbophos, on indicator Salmonella typhimurium TA-1535 strain is shown which is determined without metabolic activation. It is established that all the three preparations induce direct mutations in Pseudomonas aeruginosa. The quantity of visible mutations increases with the prolongation of exposure time and the insecticide concentration. Metaphos and phosphamide induced auxotrophic mutations. Phosphamide has the highest mutagenic activity in the assays with bacterial systems.
D001419:Bacteria / Q000187:drug effects*; D007306:Insecticides / Q000494:pharmacology*; D009153:Mutagens; D009154:Mutation; D009943:Organophosphorus Compounds; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D012486:Salmonella typhimurium / Q000187:drug effects
D007306:Insecticides; D009153:Mutagens; D009943:Organophosphorus Compounds
Sravnitel'noe izuchenie mutagennoĭ aktivnosti nekotorykh fosfororganicheskikh insektitsidov na bakteriiakh.