title: Ventilatory responses to hypocapnic vertebral artery perfusion in intact and carotid body denervated dogs.
abstract: The ventilatory responses to step changes in vertebral artery PCO2 were investigated in intact and carotid body denervated dogs. The steady-state ventilatory responses of the denervated dogs were less than those of intact dogs. However, when expressed as a ratio to the control ventilation there was no difference between the two groups. While the arterial PCO2 was held at 56 mm Hg by adding CO2 to the inspired air the perfusion of the vertebral arteries was switched from the dog's own arterial supply to hypocapnic blood. The ventilation of the denervated dogs decreased at a faster rate (half time = 130 +/- 9 sec) to a level less than the room air control ventilation. The ventilation in the intact dogs decreased at a slower rate (half time = 184 +/- 23 sec) and was maintained above the room air control level after ten minutes of hypocapnic perfusion. Increasing the medullary blood flow, as measured with radiolabeled microspheres, augmented the rate of decline of ventilation in intact dogs. We conclude, (1) the influence of the peripheral chemoreceptors appears to increase as central drive is decreasing, and (2) the remaining time course of the decrease in ventilation is related to the rate of brain stem perfusion.
mesh_terms: D000818:Animals; D001921:Brain / Q000098:blood supply; D002245:Carbon Dioxide / Q000008:administration & dosage / Q000097:blood*; D002344:Carotid Body / Q000502:physiology*; D004285:Dogs; D007269:Injections, Intra-Arterial; D012039:Regional Blood Flow; D012119:Respiration; D013997:Time Factors; D014711:Vertebral Artery
chemical_list: D002245:Carbon Dioxide