title: Inhibition of secondary IgG responses by monosaccharides: evidence for I-region control.
abstract: Certain monosaccharides selectively inhibit secondary IgG responses in vitro. Genetic analyses described in this report revealed that the inhibitory sugars differed between mouse strains and these differences mapped to the I-J and I-C subregions of the murine MHC. These results imply that interaction between T and B lymphocytes can involve the recognition of I-region controlled carbohydrate structures.
mesh_terms: D000116:Acetylgalactosamine / Q000494:pharmacology; D000818:Animals; D001667:Binding, Competitive; D004136:Dinitrobenzenes / Q000276:immunology; D005260:Female; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics; D006433:Hemocyanins / Q000276:immunology; D007117:Immunization, Secondary; D007074:Immunoglobulin G / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009005:Monosaccharides / Q000494:pharmacology*; D011995:Recombination, Genetic
chemical_list: D004136:Dinitrobenzenes; D006183:H-2 Antigens; D007074:Immunoglobulin G; D009005:Monosaccharides; D006433:Hemocyanins; D000116:Acetylgalactosamine