Renal side effects of lithium: the importance of the serum lithium level.
Patients given long-term treatment with lithium often develop an impairment of renal water reabsorption which may lead to clinically significant adverse reactions. A convenient measure of this impairment may be obtained using the ratio of urine volume (V) divided by lithium clearance (CLi). When data from a large group of patients were recalculated, this ratio showed a statistically significant correlation with the serum lithium level. This finding supports the suggestion that patients might advantageously be maintained at lower serum levels than those commonly employed.
D000042:Absorption; D001834:Body Water / Q000378:metabolism; D003894:Deamino Arginine Vasopressin / Q000494:pharmacology; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced*; D008094:Lithium / Q000009:adverse effects* / Q000097:blood; D009994:Osmolar Concentration
D008094:Lithium; D003894:Deamino Arginine Vasopressin