title: Brain glycosidases in Creutzfeldt-Jakob disease.
abstract: Several glycosidase activities were measured in frontal gray matter of 4 brains from subjects affected by Creutzfeldt-Jakob disease. The changes of N-acetyl-beta-glucosaminidase, N-acetyl-beta-galactosaminidase, beta-glucosidase, alpha-fucosidase and alpha-mannosidase were not statistically significant but significant increases of beta-glucuronidase and beta-galactosidase activities were found. These results are in accordance with several reports on brain glycosidases in scrapie and Semliki Forest virus-infected brain and could explain some changes in brain glycoconjugate content previously observed in human and experimental Creutzfeldt-Jakob disease.
mesh_terms: D000118:Acetylglucosaminidase / Q000378:metabolism; D001921:Brain / Q000201:enzymology*; D007562:Creutzfeldt-Jakob Syndrome / Q000201:enzymology*; D005966:Glucuronidase / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000378:metabolism*; D006596:Hexosaminidases / Q000378:metabolism; D006801:Humans; D008361:Mannosidases / Q000378:metabolism; D005644:alpha-L-Fucosidase / Q000378:metabolism; D001616:beta-Galactosidase / Q000378:metabolism; D001617:beta-Glucosidase / Q000378:metabolism; D048828:beta-N-Acetyl-Galactosaminidase
chemical_list: D006026:Glycoside Hydrolases; D006596:Hexosaminidases; D008361:Mannosidases; D001617:beta-Glucosidase; D001616:beta-Galactosidase; D005966:Glucuronidase; D005644:alpha-L-Fucosidase; D000118:Acetylglucosaminidase; D048828:beta-N-Acetyl-Galactosaminidase