title: Raised plasma oestrogens in infertile men with elevated levels of FSH.
abstract: In twenty oligospermic or azoospermic patients with elevated plasma FSH, the mean concentrations of plasma oestrone sulphate (843 +/- 233 pg/ml), oestrone (54 +/- 10.4 pg/ml) and oestradiol (46.6 +/- 12.6 pg/ml) were found to be significantly higher than in twenty-one normal fertile men of comparable age (593 +/- 220 pg/ml, 40.6 +/- 8.8 pg/ml and 33.1 +/- 10.9 pg/ml respectively). SHBG binding capacity was elevated in the infertile group (infertile 3.35 +/- 0.82 x 10(-8) M/l v. normal 2.76 +/- 0.89 x 10(-8) M/l) but the total plasma testosterone concentrations were comparable (infertile 5435 +/- 1578 pg/ml v. normal 5046 +/- 1102 pg/ml). Evidence was cited to support the view that Sertoli cells, in response to an unphysiological FSH stimulation, are a likely source of excessive oestrogen production. The possible significance of increased intra-testicular and circulating oestrogen in the altered state of testicular steroidogenic function in men with primary seminiferous tubular defects was discussed.
mesh_terms: D000328:Adult; D004958:Estradiol / Q000097:blood; D004967:Estrogens / Q000097:blood*; D004970:Estrone / Q000097:blood; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007248:Infertility, Male / Q000097:blood* / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D009845:Oligospermia / Q000097:blood; D012738:Sex Hormone-Binding Globulin / Q000378:metabolism
chemical_list: D004967:Estrogens; D012738:Sex Hormone-Binding Globulin; D004970:Estrone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone