Induction of group-1 and group-2 UDP-glucuronosyltransferase in microsomes from the livers of C57 Bl/6 mice.
In a study of multiple forms of liver microsomal UDPglucuronosyltransferase (EC 2.4.1.17) with different substrate specificities, enzyme induction was examined in inducible C57 Bl/6 mice pretreated with phenobarbital, 3-methylcholanthrene, Aroclor 1254, safrole, beta-naphthoflavone, and pregnenolone-16-alpha-carbonitrile. Phenobarbital and 3-methylcholanthrene were much more potent inducers than the other four compounds. 3-methylcholanthrene stimulated the glucuronidation of 4-nitrophenol, 4-bromophenol, and 4-chlorophenol ("group-1' substrates) more than phenobarbital, whereas phenobarbital stimulated the glucuronidation of 4-hydroxyphenobarbital, menthol, eugenol, 4-hydroxybiphenyl, morphine, 1-borneol, 4-hydroxyphenytoin, and 1,2,3,4-tetrahydro-1-naphthol ("group-2' substrates). This pattern is analogous to that previously observed in rat-liver microsomes.
D000818:Animals; D001140:Aroclors / Q000494:pharmacology; D001571:Benzoflavones / Q000494:pharmacology; D020111:Chlorodiphenyl (54% Chlorine); D004790:Enzyme Induction / Q000187:drug effects*; D014453:Glucuronosyltransferase / Q000096:biosynthesis*; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D008862:Microsomes, Liver / Q000201:enzymology*; D010634:Phenobarbital / Q000494:pharmacology; D011285:Pregnenolone Carbonitrile / Q000494:pharmacology; D012451:Safrole / Q000494:pharmacology; D013379:Substrate Specificity; D019324:beta-Naphthoflavone
D001140:Aroclors; D001571:Benzoflavones; D020111:Chlorodiphenyl (54% Chlorine); D011285:Pregnenolone Carbonitrile; D008748:Methylcholanthrene; D019324:beta-Naphthoflavone; D014453:Glucuronosyltransferase; D012451:Safrole; D010634:Phenobarbital