[Role of the ribosomes in controlling cellular differentiation and secondary metabolism in sporulating bacteria. I. Sporogenesis, antibiotic formation and the proteolytic activity of streptomycin-resistant mutants].
A ribosomal mutant Bacillus subtilis IG1 resistant to 100 mkg/ml of streptomycin was isolated. The strA mutation is cotransduced with the cysA gene and, consequently, maps in the ribosomal cluster. The mutation does not influence cell division but does reduce a level of sporulation as well as its antibiotic and proteolytic activity. Involvement of ribosomes in the control of sporulation and secondary metabolism of spore forming bacteria is discussed.
D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001412:Bacillus subtilis / Q000235:genetics / Q000502:physiology*; D001435:Bacteriophages / Q000235:genetics; D004789:Enzyme Activation; D009154:Mutation; D010447:Peptide Hydrolases / Q000378:metabolism*; D012270:Ribosomes / Q000502:physiology*; D013171:Spores, Bacterial / Q000502:physiology; D013307:Streptomycin / Q000037:antagonists & inhibitors*; D014161:Transduction, Genetic
D000900:Anti-Bacterial Agents; D010447:Peptide Hydrolases; D013307:Streptomycin
Rol' ribosom v kontrole kletochnoĭ differentsiatsii i vtorichnogo metabolizma sporoobrazuiushchikh bakteriĭ. Soobshchenie I. Sporogenez, antibiotikoobrazovanie i proteoliticheskaia aktivnost' u streptomitsinustoĭchivykh mutantov.