Aberrant rearrangements contribute significantly to the allelic exclusion of immunoglobulin gene expression.
A study of the organization of light- and heavy-chain immunoglobulin genes in mouse splenic B cells, spleen-derived hybridomas and plasmacytomas has unequivocally demonstrated that aberrant rearrangements are common during normal B-cell development. The results support a probabilistic model for allelic exclusion of immunoglobulin gene expression.
D000483:Alleles; D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D002872:Chromosome Deletion; D005786:Gene Expression Regulation; D007128:Immunoglobulin Fragments / Q000235:genetics; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007145:Immunoglobulin kappa-Chains / Q000235:genetics; D007146:Immunoglobulin lambda-Chains / Q000235:genetics; D007136:Immunoglobulins / Q000235:genetics*; D007942:Leukemia, Experimental / Q000276:immunology; D051379:Mice; D010954:Plasmacytoma / Q000276:immunology; D011995:Recombination, Genetic
D007128:Immunoglobulin Fragments; D007143:Immunoglobulin Heavy Chains; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains; D007136:Immunoglobulins