Effects of 4-hydroxy, 4-phenyl, caproamide on pentylenetetrazol-induced amnesia.
Early reports suggest a relationship between pentylenetetrazol-induced convulsions (PTZ) and amnesia. 4,-Hydroxy,4-phenyl caproamide (YPCA) is potently anti-convulsant against PTZ-induced convulsions. The purpose of these experiments is to show the possible role of PTZ in these amnestic effects. Experiment 1 proves YPCA antagonism of PTZ-induced convulsions in mice. Experiment 2 shows how YPCA, injected before PTZ and after animal training, protects against convulsions, leaving memory storage unaffected. However, when YPCA is injected before training (10 and 5 min) and PTZ 15 min afterwards (5 and 10 min after training), a retention impairment was observed. The results are discussed in terms that emphasize the need of convulsions in retrograde amnesia. Experiment 3 shows that foot shock is necessary for passive avoidance acquisition. Experiment 4 shows that subconvulsive doses of PTZ (5,10,20, and 40 mg/kg-1) have no effect on memory.
D000577:Amides / Q000494:pharmacology; D000647:Amnesia / Q000139:chemically induced*; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D001362:Avoidance Learning / Q000187:drug effects; D006801:Humans; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole / Q000037:antagonists & inhibitors*; D010654:Phenylbutyrates / Q000494:pharmacology*
D000577:Amides; D000927:Anticonvulsants; D010654:Phenylbutyrates; C020361:gamma-hydroxy-gamma-ethyl-gamma-phenylbutyramide; D010433:Pentylenetetrazole