The effect of blood transfusion, dopamine, and gamma hydroxybutyrate on posttraumatic ischemia of the spinal cord.
Posttraumatic spinal cord blood flow (SCBF) was assessed after elevating the mean systemic arterial pressure (mSAP) with a blood transfusion, or with an infusion of dopamine. The effect of the anesthetic agent, gamma hydroxybutyrate, was also assessed. Flows were measured using the 14C-antipyrine autoradiographic method. Animals were injured at T-1 by acute compression of the spinal cord with a clip exerting a pressure of 175 gm. Uninjured animals, with mSAP's of 120.0 +/- 17.0 mm Hg, had gray and white matter flows of 74.2 +/- 22.3 and 18.7 +/- 6.7 ml/100 gm/min, respectively, while injured untreated animals had mSAP's of 82.5 +/- 14.1 mm Hg and gray and white matter flows of 13.3 +/- 12.1 and 3.9 +/- 3.9 ml/100 gm/min, respectively, at the injury site. Blood transfusion raised the mSAP's to 127.5 +/- 13.7 mm Hg in the injured animals and doubled the flows in gray and white matter to 25.6 +/- 30.2 and 6.3 +/- 6.4 ml/100 gm/ml, respectively. Dopamine did not have as beneficial an effect as blood transfusion on either the mSAP (101.0 +/- 16.7 mm Hg) or the SCBF (gray and white matter flows of 18.4 +/- 12.4 and 5.8 +/- 5.9 ml/100 gm/min). Gamma hydroxybutyrate (GHB) had almost no effect on the mSAP or SCBF of normal animals, and in injured animals produced only a unilateral increase in flow on the less severely injured side, without affecting the mSAP.
D000818:Animals; D001345:Autoradiography; D001794:Blood Pressure; D001803:Blood Transfusion; D002245:Carbon Dioxide; D004298:Dopamine / Q000494:pharmacology*; D005260:Female; D006885:Hydroxybutyrates / Q000494:pharmacology*; D007511:Ischemia / Q000188:drug therapy* / Q000209:etiology; D010313:Partial Pressure; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D012978:Sodium Oxybate; D013116:Spinal Cord / Q000098:blood supply*; D013119:Spinal Cord Injuries / Q000150:complications*
D006885:Hydroxybutyrates; D002245:Carbon Dioxide; D012978:Sodium Oxybate; D004298:Dopamine