[Effect of a fibrin-antibiotic compound in bone and soft tissue infections].
It is reported on experimental experiences in the use of a biological adhesive system--highly concentrated native fibrinogen, thrombin and clotting factor XIII--in conjunction with local antibiotics. The results in animals are: Antibiotics in conjunction with the mentioned adhesive system give a high local concentration for a short time. The activity of the antibiotics decreases quickly within some activity of the antibiotics decreases quickly within some hours, there is no more antibiotic effect after 36 hours.
D000818:Animals; D004338:Drug Combinations; D005169:Factor VIII / Q000627:therapeutic use*; D005340:Fibrinogen / Q000627:therapeutic use*; D005839:Gentamicins / Q000627:therapeutic use*; D006168:Guinea Pigs; D010019:Osteomyelitis / Q000188:drug therapy*; D013917:Thrombin / Q000627:therapeutic use*; D014014:Tissue Adhesives; D014945:Wound Healing / Q000187:drug effects; D014946:Wound Infection / Q000188:drug therapy*
D004338:Drug Combinations; D005839:Gentamicins; D014014:Tissue Adhesives; D005169:Factor VIII; D005340:Fibrinogen; D013917:Thrombin
Zur Wirkung eines Fibrin-Antibiotikum-Verbundes bei Knochen- und Weichteil-Infektionen.