title: Funnel-web spider (Atrax robustus) antivenom. 1. Preparation and laboratory testing.
abstract: An antivenom to the Sydney Funnel-web Spider, Atrax robustus, developed in rabbits, passed exhaustive quality control studies and was subsequently tested in monkeys. It was shown to reverse the syndrome that follows envenomation in both a conscious unmonitored monkey and in two anaesthetised, monitored monkeys. This paper reports the results of these experiments. An autonomic crisis appears to be the major cause of mortality and morbidity in human victims and monkeys; this aspect of the syndrome is rapidly attenuated by the antivenom. We observed no ill-effects of antivenom.
mesh_terms: D000818:Animals; D000997:Antivenins / Q000009:adverse effects / Q000592:standards*; D001180:Arthropod Venoms / Q000037:antagonists & inhibitors; D000882:Haplorhini; D006973:Hypertension / Q000628:therapy; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D011786:Quality Control; D011817:Rabbits; D001098:Spider Bites / Q000628:therapy; D013111:Spider Venoms / Q000037:antagonists & inhibitors
chemical_list: D000997:Antivenins; D001180:Arthropod Venoms; D013111:Spider Venoms