Factor VII related antigen as an endothelial cell marker in benign and malignant diseases.
The presence and distribution of Factor VIII related antigen (FVIIR:Ag) in formation fixed, paraffin embedded tissue were studied in benign and malignant vascular tumors, inflammatory vascular diseases, normal tissue from various organs and a number of malignant tumors. The unlabeled peroxidase-anti-peroxidase method was utilized. Immunostaining was observed only in endothelial cells, in tumor cells of endothelial cell origin and in megakaryocytes and platelets. The staining method gave a distinct picture of the vascular pattern in all types of tissue examined. The demonstration of FVIIIR:Ag by means of the immunoperoxidase technique is considered a valuable method in diagnosing tumors of vascular origin. The method also facilitates detection of vascular invasion of malignant tumors in small caliber vessels.
D000941:Antigens / Q000032:analysis*; D001792:Blood Platelets / Q000276:immunology; D004727:Endothelium / Q000276:immunology; D005169:Factor VIII / Q000032:analysis / Q000276:immunology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008533:Megakaryocytes / Q000276:immunology; D009369:Neoplasms / Q000175:diagnosis; D014652:Vascular Diseases / Q000175:diagnosis; D014841:von Willebrand Factor
D000941:Antigens; D014841:von Willebrand Factor; D005169:Factor VIII