Effect of .OH scavengers on radiation damage to the erythrocyte membrane.
Thiourea, and .OH scavenger, reduced the gamma-radiation-induced changes in the rigidity of erythrocyte membrane lipids, the state of membrane proteins, and lipid peroxidation. Several .OH scavengers, but not superoxide dismutase, also inhibited the radiation-induced acceleration of the transport of a hydrophilic non-electrolyte spin label TEMPOL across the erythrocyte membrane. The effects of scavengers were usually biphasic with a maximum of the protective effect. Higher concentrations of the scavengers were less effective, as in the case of radioprotection of erythrocytes to haemolysis studied previously.
D000818:Animals; D002417:Cattle; D003037:Cobalt Radioisotopes; D004305:Dose-Response Relationship, Drug; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000528:radiation effects*; D004912:Erythrocytes / Q000528:radiation effects*; D000431:Ethanol / Q000494:pharmacology; D005561:Formates / Q000494:pharmacology; D005720:Gamma Rays; D066298:In Vitro Techniques; D008054:Lipid Peroxides / Q000378:metabolism; D008563:Membrane Lipids / Q000528:radiation effects; D008565:Membrane Proteins / Q000528:radiation effects; D011487:Protein Conformation / Q000187:drug effects / Q000528:radiation effects; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013113:Spin Labels; D013482:Superoxide Dismutase / Q000494:pharmacology; D013890:Thiourea / Q000494:pharmacology
D003037:Cobalt Radioisotopes; D005561:Formates; D008054:Lipid Peroxides; D008563:Membrane Lipids; D008565:Membrane Proteins; D011837:Radiation-Protective Agents; D013113:Spin Labels; D000431:Ethanol; D013482:Superoxide Dismutase; D013890:Thiourea