A new antiinflammatory compound, timegadine (N-cyclohexyl-N"-4-[2-methylquinolyl]-N'-2-thiazolylguanidine), which inhibits both prostaglandin and 12-hydroxyeicosatetraenoic acid (12-HETE) formation.
D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid; D000818:Animals; D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids / Q000096:biosynthesis*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D002417:Cattle; D016861:Cyclooxygenase Inhibitors; D006146:Guanidines / Q000494:pharmacology*; D006736:Horses; D066298:In Vitro Techniques; D016859:Lipoxygenase Inhibitors; D008297:Male; D011817:Rabbits; D051381:Rats; D012669:Seminal Vesicles / Q000201:enzymology
D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D016861:Cyclooxygenase Inhibitors; D006146:Guanidines; D016859:Lipoxygenase Inhibitors; C028998:timegadine; D019377:12-Hydroxy-5,8,10,14-eicosatetraenoic Acid