Studies of foetal death and foetal weight in guinea pigs fed polychlorinated biphenyls (PCB).
Pregnant guinea pigs were fed a total dose of 100 mg of the commercial PCB preparation Clophen A50 during days 16 to 60 of gestation. This treatment caused severe foetal, but no maternal, death. Contrarily, a total dose of 25 mg or 100 mg of 2,2',4,4',5,5'-hexachlorobiphenyl (HCB) did not cause foetal death in the guinea pig. The prenatal growth rate was increased by a total dose of 25 mg, but not by 100 mg, of HCB.
D000818:Animals; D005260:Female; D005313:Fetal Death / Q000139:chemically induced*; D005333:Fetus / Q000033:anatomy & histology / Q000187:drug effects*; D006168:Guinea Pigs; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D011247:Pregnancy
D011078:Polychlorinated Biphenyls