title: The role of monovalent cations in the interaction between the cytotoxic T lymphocyte and its target.
abstract: Evidence is provided for the participation of monovalent cations in both the binding and lytic phases of the lytic cycle. There appears to be one sodium requirement in the cytotoxic T lymphocyte-target binding event (effective dose 50 approximately 35 mM) and possibly another sodium requirement in the delivery of the lethal hit (ED50 less than 7 mM). Potassium can replace sodium in the binding event but antagonizes the lethal hit phase (inhibitory dose 50 approximately 110 mM). Lithium antagonizes the binding event (ID50 approximately 15 mM).
mesh_terms: D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D002414:Cations, Monovalent; D002450:Cell Communication; D003602:Cytotoxicity, Immunologic; D004533:Egtazic Acid / Q000494:pharmacology; D008094:Lithium / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000494:pharmacology; D013395:Sucrose / Q000494:pharmacology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D002414:Cations, Monovalent; D004533:Egtazic Acid; D013395:Sucrose; D008094:Lithium; D012964:Sodium; D011188:Potassium