Hamster tongue carcinogenesis. I. Characteristics of the experimental model.
Thrice weekly applications of DMBA to hamster ventral lingual mucosa, preceded by scratching with a barbed broach, led to tumor development in over 75% of the animals by 28 weeks. Macroscopic ulceration did not appear to be a necessary precursor of epithelial malignancy in this model. Tumors were preceded by a phase resembling human leukoplakia. In addition to developing tumors in the treated area, 60% of the hamsters developed tumors in the floor of the mouth or the area of mucosa on either side of the median lingual frenum.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000473:pathology; D006224:Cricetinae; D004195:Disease Models, Animal; D008297:Male; D008647:Mesocricetus; D009374:Neoplasms, Experimental / Q000209:etiology / Q000473:pathology; D010212:Papilloma / Q000473:pathology; D014059:Tongue / Q000293:injuries*; D014062:Tongue Neoplasms / Q000209:etiology* / Q000473:pathology
D015127:9,10-Dimethyl-1,2-benzanthracene