title: [Use of agar diffusion method for separate determination of concentration of streptomycin and rifampicin in the blood in the presence of isoniazid].
abstract: Conditions for determination of streptomycin and rifampicin in the blood serum on their combined use, as well as in the presence of isoniazid are described. For determination of the blood levels of streptomycin administered in combination with rifampicin it is recommended tat a variant of Bac. mycoides 537 resistant to rifampicin be used. When the rifampicin levels are determined in undiluted serum, the value obtained should be multiplied by 1.4. When a 2-fold dilution of the serum is used, the value is multiplied by 1.15. This provides an indicator maximally close to the real content of the antibiotic in the blood serum.
mesh_terms: D001407:Bacillus / Q000187:drug effects; D003470:Culture Media; D004347:Drug Interactions; D006801:Humans; D005779:Immunodiffusion / Q000379:methods; D066298:In Vitro Techniques; D007538:Isoniazid / Q000097:blood*; D007700:Kinetics; D008826:Microbial Sensitivity Tests; D012293:Rifampin / Q000097:blood*; D013307:Streptomycin / Q000097:blood*
chemical_list: D003470:Culture Media; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin
vernacular_title: Metod diffuzii v agar dlia razdel'nogo opredeleniia kontsentratsii streptomitsina i rifampitsina pri ikh sovmestnom prisutstvii s izoniazidom v syvorotke krovi.