title: [Delta-antigen in hepatitis B].
abstract: Among 571 liver biopsies delta-Ag was found in 10 of 365 HBsAg positive patients (9 with CAH, 1 with CPH). Delta-Ag was demonstrated in nuclei and cytoplasm of liver cells in both cryostat and paraffin sections. Follow-up studies revealed persistence of delta-Ag for as long as 6 years and temporary appearance or loss of Dane particle-associated parameters without a change in the concomitant inflammation. These findings are compatible with the hypothesis that delta-Ag represents a defective viral agent which modulates, by superinfection, the typical viral expression patterns of HBV infection.
mesh_terms: D006509:Hepatitis B / Q000276:immunology*; D006511:Hepatitis B Antigens / Q000032:analysis*; D006515:Hepatitis B virus / Q000302:isolation & purification; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000032:analysis*; D007138:Immunoglobulin delta-Chains / Q000032:analysis*; D008099:Liver / Q000276:immunology
chemical_list: D006511:Hepatitis B Antigens; D007143:Immunoglobulin Heavy Chains; D007138:Immunoglobulin delta-Chains
vernacular_title: Delta-Antigen bei Hepatitis B.