[Effect of pyrazidole and deprenyl on monoamine oxidase in the rat intestine].
Pyrazidol (1,10-trimethylene-3-methyl-1,2,3,4-tetrahydropyrazino(1,2-a)indole hydrochloride) in low concentrations (0.005 mM) completely blocks the deamination of serotonin, partially that of tyramine, and does not virtually affect the deamination of 2-phenylethylamine by the mitochondria of intestinal cells. There is evidence for the presence of types A and B monoamine oxidases in the rat intestine. Pyrazidol appears to be a selective inhibitor of type A monoamine oxidase of the rat intestine.
D000818:Animals; D002227:Carbazoles / Q000494:pharmacology*; D066298:In Vitro Techniques; D007422:Intestines / Q000201:enzymology*; D007527:Isoenzymes / Q000037:antagonists & inhibitors*; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines / Q000494:pharmacology*; D051381:Rats; D012642:Selegiline / Q000494:pharmacology*
D002227:Carbazoles; D007527:Isoenzymes; D008996:Monoamine Oxidase Inhibitors; D010627:Phenethylamines; D012642:Selegiline; C009830:pirlindole
Vliianie pirazidola i depranila na monoaminoksidazu kishechnika krysy.