Therapeutic effect of aspirin in sickle cell anaemia.
This work was carried out to demonstrate the possibility of beneficial therapeutic effects of aspirin in sickle cell anaemia patients. Two groups of 50 patients each, with haemoglobin genotype SS were studied, one group receiving soluble aspirin daily for 6 weeks, while the other was used as a control. There was evidence of increase in oxygen affinity, in haemoglobin levels, and in the life span of RBC, probably due to acetylation of HbS.
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000188:drug therapy*; D001241:Aspirin / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004905:Erythrocyte Aging / Q000187:drug effects; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D008297:Male; D009549:Nigeria; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure
D006454:Hemoglobins; D001241:Aspirin; D010100:Oxygen