Prevention of kainic acid-induced seizure-like activity by antiepileptic drugs.
Intracerebroventricular kainic acid (KA) injections produced a seizure-like activity syndrome in mice. It was shown that some antiepileptic drugs (lefadol, depakine, phenobarbital) inhibited this syndrome, diazepam being the most effective in this respect. However, acetazolamide and diphenylhydantoin exerted a rather weak or negligible effect even when given in high doses. Present results may suggest that the effects of intracerebroventicular injections of KA may be employed to test antiepileptic properties of drugs.
D000086:Acetazolamide / Q000627:therapeutic use; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D003975:Diazepam / Q000627:therapeutic use; D005260:Female; D007276:Injections, Intraventricular; D007608:Kainic Acid / Q000008:administration & dosage; D008297:Male; D051379:Mice; D010634:Phenobarbital / Q000627:therapeutic use; D010672:Phenytoin / Q000627:therapeutic use; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D013388:Succinimides / Q000627:therapeutic use; D014635:Valproic Acid / Q000627:therapeutic use
D000927:Anticonvulsants; D013388:Succinimides; C002318:3-bromophenylsuccinimide; D014635:Valproic Acid; D010672:Phenytoin; D000086:Acetazolamide; D003975:Diazepam; D007608:Kainic Acid; D010634:Phenobarbital