Potentiation of the biological activities of daunomycin and adriamycin by ascorbic acid and dimethylsulfoxide.
L-Ascorbic acid (0.57 mM) and dimethylsulfoxide (14.1 mM) were found to potentiate four times the antibacterial activities of daunomycin and adriamycin in the Staphylococcus aureus test. This effect, however, could not be demonstrated against eukaryotic cells and leukemia P 388 in mice.
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D003630:Daunorubicin / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice; D012441:Saccharomyces cerevisiae / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013769:Tetrahymena pyriformis / Q000187:drug effects
D004317:Doxorubicin; D001205:Ascorbic Acid; D004121:Dimethyl Sulfoxide; D003630:Daunorubicin