Age-related DNA fragmentation in two varieties of Drosophila melanogaster, Phaseolus (cotyledons), and three tissues of the mouse.
Agarose gel electrophoresis showed that no age-related DNA fragmentation occurred in wild-type or vestigial wing Drosophila, or in DNA from mouse brain and heart. DNA from mouse liver possessed a large fragment, estimated at 24 megadaltons, in all ages tested. Phaseolus cotyledon DNA possessed a fragment of approximately 3.5 megadaltons in both imbibed seeds and 12-day-old cotyledons. Thus, there appeared to be no age-related increase in the break-down of DNA into large fragments.
D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism; D004247:DNA / Q000302:isolation & purification / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000378:metabolism*; D004587:Electrophoresis, Agar Gel; D005260:Female; D008099:Liver / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D009206:Myocardium / Q000378:metabolism; D010944:Plants / Q000378:metabolism*
D004247:DNA