Food allergy and atopic dermatitis in children: treatment with oral sodium cromoglycate.
Thirty-five children with atopic dermatitis were proven to be allergic to various foods by dietary elimination and challenge, radio-allergosorbent test (RAST) and human basophil degranulation test (HBDT). Oral sodium cromoglycate improved skin lesions in these patients and protected them from the effects of challenge with food allergens. This protective effect of oral sodium cromoglycate may be explained by the blocking of the immune response in the gut wall and of antigen entry.
D000284:Administration, Oral; D000293:Adolescent; D001491:Basophils / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004205:Cromolyn Sodium / Q000009:adverse effects / Q000627:therapeutic use*; D003594:Cytoplasmic Granules / Q000276:immunology; D003876:Dermatitis, Atopic / Q000188:drug therapy*; D005512:Food Hypersensitivity / Q000188:drug therapy*; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D007223:Infant; D011852:Radioallergosorbent Test
D007074:Immunoglobulin G; D007073:Immunoglobulin E; D004205:Cromolyn Sodium