Effect of cortisone on permeability of the neonatal rat lung to drugs.
The effect of cortisone (5 mg/animal i.p. on day 5 after birth) on the development of adult-type permeability characteristics in the lung was investigated in rats 6-18 days of age. In both treated and control rats, the lipid-soluble drug procainamide was absorbed at similar rates in all age groups. In contrast, in cortisone-treated animals, pulmonary absorption rates for the lipid-insoluble compounds mannitol and p-aminohippuric acid declined to adult levels at the age of 6 days, which was 12 days earlier than in controls. Cortisone treatment thus accelerates development of adult permeability characteristics in the pulmonary epithelium.
D000375:Aging; D000618:Aminohippuric Acids / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000187:drug effects*; D003348:Cortisone / Q000494:pharmacology*; D005260:Female; D007700:Kinetics; D008168:Lung / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D008353:Mannitol / Q000378:metabolism*; D011342:Procainamide / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D010130:p-Aminohippuric Acid / Q000378:metabolism*
D000618:Aminohippuric Acids; D008353:Mannitol; D011342:Procainamide; D003348:Cortisone; D010130:p-Aminohippuric Acid