title: Alanine turnover in the postabsorptive state and during parenteral hyperalimentation before and after surgery.
abstract: Influence of total parenteral nutrition and operation on alanine turnover and venous alanine concentration was determined in 5 patients with stomach carcinoma using single technique of U-14C alanine. Every patient served at his own control. In the postabsorptive state alanine turnover was 1.63 +/- 0.31 mgatC . min-1, not different from a control group (1.84 +/- 0.60 mgatC . min-1); during total parenteral nutrition alanine turnover increased to 3.21 +/- 0.5g mgatC . min-1 with a rise in alanine concentration from 0.96 +/- 0.17 mgatC . L-1 + 0.69 +/- 0.22 mgatC . L-1. After surgery during the same total parenteral nutrition alanine turnover increased further to 3.78 +/- 0.17 mgatC . min-1 with a lowering of alanine concentration to 1.44 +/- 0.22 mgatC . L-1. The present results show the distinct influence of TPH on alanine kinetics. The present data indicate that alanine turnover cannot be deduced from blood alanine concentration.
mesh_terms: D000042:Absorption; D000328:Adult; D000409:Alanine / Q000097:blood*; D005215:Fasting; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D010288:Parenteral Nutrition; D010289:Parenteral Nutrition, Total; D011184:Postoperative Period; D013274:Stomach Neoplasms / Q000601:surgery*
chemical_list: D000409:Alanine