Antifertility effects of clonidine in laying hens.
Clonidine was anovulatory and markedly antigonadal in laying hens when infused for 1 week from minipump implants at daily rates of 1.08 mg per hen or greater. The ovaries of hens treated with clonidine responded to FSH injections which suggests that the antigonadal effect of clonidine resulted from a reduction in the output of gonadotropin by the pituitary. These data suggest that alpha 2 receptors may be important in regulating avian fertility.
D000818:Animals; D002645:Chickens / Q000502:physiology*; D003000:Clonidine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004343:Drug Implants; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005640:Follicle Stimulating Hormone / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000033:anatomy & histology; D010057:Oviducts / Q000033:anatomy & histology
D004343:Drug Implants; D005640:Follicle Stimulating Hormone; D003000:Clonidine