Antiinflammatory agents. 2. Syntheses and antiinflammatory activity of substituted 2-aminophenylacetic acid derivatives.
Several substituted 2-aminophenylacetic acid derivatives were prepared and tested for in vitro prostaglandin synthetase inhibition activity and for in vivo antiinflammatory activity. The 2-amino substituent is beneficial to potency in the inhibition of prostaglandin synthetase for the 3-phenoxy, 4-phenyl, and 3-benzoyl series, but only the 3-benzoyl series shows increased antiinflammatory potency in the in vivo assay.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D002351:Carrageenan; D002417:Cattle; D055598:Chemical Phenomena; D002621:Chemistry; D016861:Cyclooxygenase Inhibitors; D066298:In Vitro Techniques; D008297:Male; D008968:Molecular Conformation; D010648:Phenylacetates / Q000138:chemical synthesis* / Q000494:pharmacology; D010996:Pleural Effusion
D000893:Anti-Inflammatory Agents; D016861:Cyclooxygenase Inhibitors; D010648:Phenylacetates; D002351:Carrageenan