Are HLA antigens important in the development of alcohol-induced liver disease?
The prevalences of 10 HLA-A and 16 HLA-B antigens were determined in 50 patients with alcoholic cirrhosis and 120 alcoholic patients without cirrhosis and compared with those in a control group of 550 healthy subjects from the same geographical area. B40 was absent in the patients with cirrhosis but was found in 18 (15%) of the patients without cirrhosis (p = 0.0087). No other association was noted. It is concluded that there is no good evidence to date of an association between HLA antigen state and susceptibility to alcohol-induced cirrhosis.
D000017:ABO Blood-Group System; D000368:Aged; D000437:Alcoholism / Q000276:immunology; D005260:Female; D006680:HLA Antigens / Q000032:analysis*; D006512:Hepatitis B Core Antigens / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000276:immunology; D008108:Liver Diseases, Alcoholic / Q000276:immunology*; D008297:Male; D008875:Middle Aged
D000017:ABO Blood-Group System; D006680:HLA Antigens; D006512:Hepatitis B Core Antigens; D006514:Hepatitis B Surface Antigens