Amphetamine stereotypies and polyribosomal disaggregation in rats: effects of adrenergic and serotonergic blocking agents.
To find the specific chemical moiety responsible for the disaggregation of polyribosomes after induction of aberrant behavior by d-amphetamine, specific amine blockers and reserpine were utilized. It appears that dopamine is responsible for both the disaggregation of polyribosomes and stereotypic behavior while the roles of serotonin and norepinephrine are not significant in this system.
D000818:Animals; D001921:Brain / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology*; D006801:Humans; D008781:Methyltyrosines / Q000494:pharmacology; D008784:Methysergide / Q000494:pharmacology; D010868:Pimozide / Q000494:pharmacology; D011132:Polyribosomes / Q000187:drug effects*; D051381:Rats; D012110:Reserpine / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000494:pharmacology*; D013239:Stereotyped Behavior / Q000187:drug effects* / Q000502:physiology; D013565:Sympatholytics / Q000494:pharmacology*; D019805:alpha-Methyltyrosine
D008781:Methyltyrosines; D012702:Serotonin Antagonists; D013565:Sympatholytics; D010868:Pimozide; D019805:alpha-Methyltyrosine; D012110:Reserpine; D003913:Dextroamphetamine; D008784:Methysergide