[Inhibitory effects of tamoxifen on the normal differentiation of the female gonads of the quail embryo].
Early treatment of Quail eggs by tamoxifen produces a striking inhibition on normal differentiation of the female gonads. This anti-estrogen restricts cortical proliferation in the ovary while it favours the development of the medulla of both gonads. As a result their morphology and organization diverge toward a more neutral or even testicular pattern. Since tamoxifen is able to compete with the endogenous estrogens, these results underline their role in female differentiation of the Quail gonads.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D004625:Embryo, Nonmammalian / Q000187:drug effects; D005260:Female; D010053:Ovary / Q000166:cytology / Q000187:drug effects / Q000196:embryology*; D011784:Quail; D013629:Tamoxifen / Q000494:pharmacology*
D013629:Tamoxifen
Action antagoniste du tamoxifene sur la differenciation normale des gonades femelles de l'embryon de Caille.