Mutational events in mouse myeloma cells.
Cultured mouse myeloma cells frequently generate variants in immunoglobulin expression and structure. In this paper the authors will review the phenotypes of the variants which have been identified and discuss the mechanisms which may be responsible for the somatic instability of the immunoglobulin genes in mouse myeloma cells.
D000596:Amino Acids / Q000235:genetics; D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D002241:Carbohydrates / Q000235:genetics; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D002872:Chromosome Deletion; D005787:Gene Frequency; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000096:biosynthesis / Q000145:classification / Q000235:genetics; D007147:Immunoglobulin Light Chains / Q000096:biosynthesis / Q000235:genetics; D007136:Immunoglobulins / Q000096:biosynthesis / Q000145:classification / Q000235:genetics*; D046911:Macromolecular Substances; D051379:Mice; D008807:Mice, Inbred BALB C; D009154:Mutation; D009194:Myeloma Proteins / Q000235:genetics*; D010641:Phenotype; D010954:Plasmacytoma / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D051381:Rats
D000596:Amino Acids; D002241:Carbohydrates; D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D007136:Immunoglobulins; D046911:Macromolecular Substances; D009194:Myeloma Proteins