Glutaraldehyde tanned ovine collagen compared with polytetrafluoroethylene (Gore-Tex) as a conduit for small calibre artery substitution; an experimental study in dogs.
Collagen tubes with a polyester mesh endoskeleton were grown in sheep around silastic mandrils and were then tanned in alkaline glutaraldehyde. Tanned ovine collagen conduits and polytetrafluoroethylene conduits (Gore-Tex), each 10 cm long and 6 mm wide, were deployed in parallel as aorto-iliac bypass grafts in 10 dogs. The grafts remained patent for periods up to and exceeding 23 months. No grafts showed aneurysmal dilatation. All grafts formed a neointima lined with cells. In the Gore-Tex grafts there was fibrous tissue ingrowth through the wall which resulted in progressive and irregular luminal narrowing. This was not seen in the tanned ovine collagen grafts.
D000818:Animals; D001158:Arteries / Q000601:surgery*; D001672:Biocompatible Materials; D001807:Blood Vessel Prosthesis / Q000592:standards*; D003094:Collagen / Q000627:therapeutic use; D004285:Dogs; D005976:Glutaral / Q000627:therapeutic use; D011138:Polytetrafluoroethylene / Q000627:therapeutic use
D001672:Biocompatible Materials; D011138:Polytetrafluoroethylene; D003094:Collagen; D005976:Glutaral