Obesity: can some fat cells enlarge while others are shrinking?
CBA mice were made obese by injection with gold thioglucose (GTG). After receiving transplants of "lean" and "GTG-obese" fat under separate kidney capsules, the host mice were fed a restricted diet for three weeks. Over this period, the fat cells in the lean grafts enlarged whereas the fat cells in the GTG-obese grafts shrank. Concurrent fat loss and fat gain can therefore take place.
D000273:Adipose Tissue / Q000473:pathology* / Q000637:transplantation; D000818:Animals; D006051:Aurothioglucose; D004032:Diet; D005260:Female; D007668:Kidney; D051379:Mice; D008808:Mice, Inbred CBA; D009765:Obesity / Q000139:chemically induced / Q000473:pathology*; D014184:Transplantation, Homologous
D006051:Aurothioglucose