[Ultrastructural visualization of binding and internalization of cholera and tetanuts toxins].
In monolayer cultures of a liver line, a population of non-coated membrane microinvaginations is preferentially involved in both the initial binding and subsequent internalization of colloidal gold-labelled cholera and tetanus toxins. These two toxins thus appear to be internalized via another pathway than most other polypeptide ligands studied, which enter cells via coated plasma membrane invaginations.
D000818:Animals; D001665:Binding Sites; D002460:Cell Line; D002462:Cell Membrane / Q000378:metabolism / Q000648:ultrastructure*; D002772:Cholera Toxin / Q000378:metabolism*; D004848:Epithelium / Q000378:metabolism; D008099:Liver; D008854:Microscopy, Electron; D051381:Rats; D013744:Tetanus Toxin / Q000378:metabolism*
D013744:Tetanus Toxin; D002772:Cholera Toxin
Visualisation ultrastructurale de la liaison et de l'internalisation des toxines du choléra et du tétanos.