Effect of ethanol ingestion on outcome of drug overdose.
It was traditionally assumed that ethanol, as part of an intentional drug overdose, will increase morbidity and mortality. The authors prospectively studied the effect of ethanol on the outcome of intentional drug overdose in 468 adults, 196 of whom required hospital admission. Ethanol was detected in significantly fewer patients who required admission. Ethanol ingestion was not related to coma, impaired vital signs or mortality. Indeed, the duration of coma was significantly shorter in patients in whom ethanol was detected, but this group had a lesser incidence of multiple drug and nonbarbiturate hypnotic ingestion and a greater incidence of chronic ethanol use. Thus, it seems that ethanol is not associated with a worse clinical course if the drug overdose patient reaches medical care before an irreversible event.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning; D001463:Barbiturates / Q000506:poisoning; D001569:Benzodiazepines / Q000506:poisoning; D003128:Coma / Q000139:chemically induced; D003975:Diazepam / Q000097:blood / Q000506:poisoning; D004347:Drug Interactions; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006993:Hypnotics and Sedatives / Q000506:poisoning; D008297:Male; D008875:Middle Aged; D003708:Nordazepam / Q000097:blood / Q000506:poisoning; D010640:Phenothiazines / Q000506:poisoning; D011041:Poisoning / Q000097:blood; D012459:Salicylates / Q000506:poisoning; D013406:Suicide, Attempted
D000929:Antidepressive Agents, Tricyclic; D001463:Barbiturates; D006993:Hypnotics and Sedatives; D010640:Phenothiazines; D012459:Salicylates; D001569:Benzodiazepines; D000431:Ethanol; D003708:Nordazepam; D003975:Diazepam