title: Sex-linked lethal frequencies produced by 7,12-dimethylbenz[a]anthracene in five Drosophila melanogaster wild strains.
abstract: 7,12-Dimethylbenz[a]anthracene (DMBA) was tested for the  induction of mutations in 5 strains of Drosophila melanogaster. Larvae were fed mixtures containing either 1.0 or 4.0 mM DMBA in darkness. After emergence the males were mated to Basc females to test for sex-linked lethals. Canton-S males produced the highest frequency with no significant differences in the induction of lethals by the 2 concentrations. DMBA was slightly mutagenic in Oregon-R males over controls without significant differences between the 2 concentrations. Berlin-K, Lausanne-S and Urbana-S males all produced significantly more mutations at the 4.0-mM than the 1.0-mM concentrations. DMVA produced partial sterility in Canton-S and Urbana-S males. The DMBA mutation frequencies of all 5 wild strains are interpreted as being related to the levels of activating enzymes that metabolize DMBA.
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene / Q000494:pharmacology*; D000818:Animals; D001551:Benz(a)Anthracenes / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000235:genetics; D005804:Genes, Lethal; D008040:Genetic Linkage; D009152:Mutagenicity Tests; D009153:Mutagens; D012730:Sex Chromosomes
chemical_list: D001551:Benz(a)Anthracenes; D009153:Mutagens; D015127:9,10-Dimethyl-1,2-benzanthracene