[Ambulant treatment of hypertension with cardiotensin (author's transl)].
A fixed combination preparation consisting of a betablocker and diuretics was tested in 25 outpatients suffering from essential hypertension grades I and II (WHO). The raised blood pressures of the placebo phase fell highly significantly to normal values in th course of the 8 weeks' treatment. The ergometric load testing under standardized conditions showed a significant reduction of blood pressure increase, a significant rise in load capacity, and a decrease in the pressure rate product. Apart from the increase in serum acid in one case, no clinically relevant changes in the laboratory values were observed. Tolerance was good. The side effects mentioned by 10 patients were mild and did not influence the course of treatment. Patient compliance, measured twice in th course of the trial by means of urine fluorescence, was very high (95%).
D000328:Adult; D000368:Aged; D001581:Benzothiadiazines / Q000627:therapeutic use*; D002046:Bupranolol / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010349:Patient Compliance; D005082:Physical Exertion; D011412:Propanolamines / Q000627:therapeutic use*; D014223:Triamterene / Q000627:therapeutic use*; D014527:Uric Acid / Q000097:blood
D001581:Benzothiadiazines; D004338:Drug Combinations; D011412:Propanolamines; C025276:bemetizide, bupranolol, triamterene drug combination; D014527:Uric Acid; D002046:Bupranolol; D014223:Triamterene
Ambulante behandlung der Hypertonie mit Cardiotensin.