Induction of ovulation in a true hermaphrodite with male phenotype.
Ovulation was induced in a 16-yr-old 46 XX/47 XXY true hermaphrodite with a male phenotype. The presence of testicular tissue was assessed by a normal androgen response to hCG. Administration of FSH and LH for 8 consecutive days, followed by a single dose of hCG, induced a biphasic serum profile of 17 beta-estradiol and progesterone similar to that observed in normal menstrual cycles. In addition, a significant rise in serum testosterone was noticed during the luteal phase. Laparotomy revealed the presence of a uterus, with evidence of endometrial bleeding and absence of a vagina. These results demonstrated that gonadotropins were able to induce follicular maturation, ovulation, and endometrial bleeding in a true hermaphrodite resembling a normal ovulatory cycle. Gonadotropin administration can be used as a diagnostic tool for establishing the presence of ovarian tissue in this gonadal development abnormality.
D000293:Adolescent; D006063:Chorionic Gonadotropin; D013196:Dihydrotestosterone / Q000097:blood; D012734:Disorders of Sex Development / Q000235:genetics / Q000503:physiopathology*; D004958:Estradiol / Q000097:blood; D005640:Follicle Stimulating Hormone; D006801:Humans; D007621:Karyotyping; D007986:Luteinizing Hormone; D008297:Male; D010062:Ovulation Induction; D010641:Phenotype; D011374:Progesterone / Q000097:blood; D013739:Testosterone / Q000097:blood
D006063:Chorionic Gonadotropin; D013196:Dihydrotestosterone; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone