title: Measurement of 24-hour whole-body retention of Tc-99m HEDP by a gamma camera.
abstract: Measurement of 24-hr whole-body retention of Tc-99m HEDP, using a shadow-shield, whole-body monitor, has been shown to be a sensitive measure of skeletal metabolism and of value in the diagnosis of metabolic bone disease. A new method of measuring the retention using a gamma camera, with a scanning (fishtail) collimator and patient placed at 2.,3 m distance, has been evaluated in 18 patients undergoing routine bone scans. The patients also had whole-body monitor (WBM), and the two methods correlated well, yielding a regression line GC% = -0.82 + 0.98 WBM%, r = 0.975, p less than 0.001. The limitations to, and repeatability of, the gamma-camera measurements are discussed. This work shows that measurements of whole-body retention can be obtained in any nuclear medicine department possessing a gamma camera with a suitable collimator.
mesh_terms: D001822:Body Burden; D001851:Bone Diseases, Metabolic / Q000000981:diagnostic imaging / Q000378:metabolism*; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism; D012968:Etidronic Acid / Q000378:metabolism*; D005069:Evaluation Studies as Topic; D006801:Humans; D015609:Organotechnetium Compounds; D010781:Photography / Q000295:instrumentation; D011877:Radionuclide Imaging / Q000295:instrumentation* / Q000379:methods; D012044:Regression Analysis; D013667:Technetium / Q000378:metabolism*; D013997:Time Factors; D014915:Whole-Body Counting / Q000295:instrumentation
chemical_list: D015609:Organotechnetium Compounds; C019561:technetium Tc 99m etidronate; D013667:Technetium; D012968:Etidronic Acid