Immunoperoxidase characterization of pharyngeal plasmacytoma.
Extramedullary plasmacytomas (EMPs) are plasma cell neoplasms that most frequently arise along the upper airways and often do not secrete detectable amounts of M protein at the time of diagnosis. The present report describes the immunohistochemical characterization of an EMP in a young woman. The unlabeled peroxidase-antiperoxidase method was employed to demonstrate cytoplasmic immunoglobulin determinants in routinely processed, paraffin-embedded tissue. Only kappa light chain and lambda heavy chain determinants were found in the cytoplasm of the neoplastic plasma cells; essentially identical results were found in both initial and recurrent lesions separated by a 16-month interval. This exclusive staining of one light chain type associated with only one heavy chain represents a monoclonal staining pattern that is typical of B-cell neoplasms. Such characterization of EMPs on the basis of cytoplasmic immunoglobulin class and type may provide prognostic information analogous to the classification of multiple myeloma by immunoelectrophoresis.
D000234:Adenoids / Q000276:immunology; D000328:Adult; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007145:Immunoglobulin kappa-Chains / Q000032:analysis; D007146:Immunoglobulin lambda-Chains / Q000032:analysis; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000276:immunology; D010610:Pharyngeal Neoplasms / Q000276:immunology*; D010954:Plasmacytoma / Q000276:immunology*; D011379:Prognosis; D014067:Tonsillar Neoplasms / Q000276:immunology
D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains