title: Activity of creatine kinase in sera from healthy women, carriers of Duchenne muscular dystrophy and cord blood, determined by the "European" recommended method with NAC-EDTA activation.
abstract: Creatine kinase activity has been measured at 37 degrees C in sera from healthy women, carriers of Duchenne muscular dystrophy and cord blood, with activation by N-acetyl cysteine (NAC) and EDTA as recommended by several European committees on standardisation. The upper limit of the reference range for healty women was found to be 170 U/l. The distributions of creatine kinase activities in healthy and carrier women have been used to calculate probability of carrier status as a function of creatine kinase activity. Although the range of creatine kinase activities in normal cord blood is wide, the data provide a basis for interpretation when Duchenne muscular dystrophy is suspected.
mesh_terms: D000111:Acetylcysteine / Q000494:pharmacology*; D000293:Adolescent; D000328:Adult; D003402:Creatine Kinase / Q000097:blood* / Q000235:genetics; D004492:Edetic Acid / Q000494:pharmacology*; D005260:Female; D005312:Fetal Blood / Q000201:enzymology*; D006580:Genetic Carrier Screening; D006801:Humans; D007700:Kinetics; D008875:Middle Aged; D009136:Muscular Dystrophies / Q000201:enzymology* / Q000235:genetics; D011247:Pregnancy; D012016:Reference Values
chemical_list: D004492:Edetic Acid; D003402:Creatine Kinase; D000111:Acetylcysteine