N-nitrosomethylurea-induced rat mammary tumours as models of human breast cancer.
A histopathological study is reported of the autopsy finding in two strains of rats treated with N-methyl-N-nitrosourea (MNU). The induced mammary tumours were histologically indistinguishable from those produced by dimethylbenz(a)anthracene (DMBA). A number of other primary tumours were found and there was no evidence of metastases.
D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D008770:Methylnitrosourea; D009607:Nitrosourea Compounds; D051381:Rats; D011916:Rats, Inbred F344; D011920:Rats, Inbred WF
D009607:Nitrosourea Compounds; D015127:9,10-Dimethyl-1,2-benzanthracene; D008770:Methylnitrosourea