Oxidative deamination of 14C putrescine in mouse tissues in vivo.
Oxidative deamination of 14C putrescine was examined in vivo in mice. Exogenous putrescine is catabolized rapidly; 2.5 min after i.v. putrescine infection, its main oxidative metabolites, namely GABA and an unidentified compound were detected in all tissues tested; inhibition of DAO activity by aminoguanidine strongly suppressed formation of both products.
D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism; D000818:Animals; D002250:Carbon Radioisotopes; D003641:Deamination; D005260:Female; D051379:Mice; D010084:Oxidation-Reduction; D011700:Putrescine / Q000378:metabolism*; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D002250:Carbon Radioisotopes; D005680:gamma-Aminobutyric Acid; D006631:Amine Oxidase (Copper-Containing); D011700:Putrescine