Effect of Pseudomonas aeruginosa lipopolysaccharide on phytohaemagglutinin induced lymphocyte transformation.
Examination of the mitogenic response of lymphocytes in 50 blood samples from 17 patients suffering from Pseudomonas aeruginosa infection and on 5 occasions from 5 healthy persons revealed that a Pseudomonas lipopolysaccharide unfamiliar to the lymphocytes decreased, whereas the purified O-antigen of the infection causing Pseudomonas serogroup increased the effect of phytohaemagglutinin on parallel lymphocyte cultures prepared from the same blood samples during the whole infectious process. After complete recovery, however, the lipopolysaccharide of the infection causing P. aeruginosa strain inhibited again the phytohaemagglutinin response as if the lymphocytes had never met it. The model seems to offer a possibility to follow up in vivo the signs of the changes in the cellular background during the reaction given on Pseudomonas lipopolysaccharides.
D000942:Antigens, Bacterial; D006801:Humans; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008213:Lymphocyte Activation; D010835:Phytohemagglutinins; D011552:Pseudomonas Infections / Q000276:immunology*; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D013997:Time Factors
D000942:Antigens, Bacterial; D008070:Lipopolysaccharides; D010835:Phytohemagglutinins