Multiple myeloma and acute myelomonocytic leukemia: simultaneous occurrence without previous chemotherapy.
A patient with acute myelomonocytic leukemia was found to have IgG paraprotein on serum electrophoresis Bence Jones K proteinuria and increased plasma cells (30%) on marrow examination. The simultaneous occurrence of the two diseases was well documented by cytochemical immunological and electron-microscopic findings. Bone marrow chromosome investigations showed an abnormal karyotype: hypodiploidy was prevalent and marker chromosomes were present. A possible relationship between acute leukemia and multiple myeloma is discussed.
D000368:Aged; D001853:Bone Marrow / Q000648:ultrastructure; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000235:genetics; D008297:Male; D009101:Multiple Myeloma / Q000150:complications* / Q000235:genetics; D009194:Myeloma Proteins / Q000032:analysis; D010950:Plasma Cells / Q000473:pathology
D009194:Myeloma Proteins