[Protective effects of muscimol on acute brain ischemia in the rat (author's transl)].
Rats given i.c.v. muscimol overcome a greater number of hypoxic episodes before dying compared with controls whereas animals that receive baclofen (another GABAergic agonist) or GABA itself tolerate fewer episodes than controls. Thus, chloride ions ionophoric site activation appears to be necessary in order to obtain any GABAergic antihypoxic protection whereas GABAergic site activated by both baclofen and GABA would induce an opposite effect.
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D002546:Ischemic Attack, Transient / Q000517:prevention & control*; D007700:Kinetics; D008297:Male; D009118:Muscimol / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D010080:Oxazoles; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D001418:Baclofen
Action protectrice du muscimol contre les effets de l'ischémie cérébrale aiguë chez le rat.