title: Hemoperfusion in diabetic coma.
abstract: Hemoperfusion on ionic exchange resins in the therapy of diabetic keto-acidosis (DKA) coma is proposed. Resins used are strong anionic resins in mixed form able to release bicarbonates and to trap ketoanions and organic anions in a stoichiometric manner. A series of trials in open circuit are performed in order to search for a suitable mixture of resins and to establish the amounts of HCO3- and ketoanions respectively released or entrapped. Therefore, ten simulated hemoperfusions in closed circuit systems were performed, utilizing cartridges containing 1,700 g of mixed resin (9% HCO3- form and 91% Cl- form). The results indicate that all side effects of bicarbonate i.v. therapy of DKA coma are avoided because of the smooth HCO3- administration to the patient. Furthermore, a good removal of ketoanions and organic acids is obtained without changing the blood osmolality.
mesh_terms: D001639:Bicarbonates / Q000378:metabolism; D016883:Diabetic Ketoacidosis / Q000188:drug therapy*; D006464:Hemoperfusion / Q000295:instrumentation*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007475:Ion Exchange Resins / Q000627:therapeutic use; D009994:Osmolar Concentration
chemical_list: D001639:Bicarbonates; D007475:Ion Exchange Resins