title: Indirect androgenic control of citrate accumulation in rat ventral prostate.
abstract: Androgenic control of citrate metabolism was studied by measuring the conversion of (2-14C)acetate or (6-14C)glucose to (14C)citrate and 14CO2 in the ventral prostate of the rat. The decarboxylation of (2-14C)acetate showed that androgen preferentially increased (14C)citrate oxidation, probably to meet the increased energy demands of cellular synthetic reactions. This led to the decreased accumulation of (14C)citrate from (2-14C)acetate. On the other hand, both the production of (14C)citrate and the formation of 14CO2 from (6-14C)glucose were decreased by castration and increased by testosterone, this being mainly due to the androgenic control of pyruvate dehydrogenase. These changes were more marked and rapid than those in oxygen consumption, in (2-14C)acetate oxidation, or in the total content of prostatic citrate that was maintained by testosterone. Glucose as the main source of citrate in testosterone-treated rats can thus be replaced by alternative substrates in castrated rats. The rate of citrate accumulation could be more dependent on the number of secretory cells than their hormonal activation.
mesh_terms: D000085:Acetates / Q000378:metabolism; D000728:Androgens / Q000502:physiology*; D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D002951:Citrates / Q000378:metabolism*; D019343:Citric Acid; D005947:Glucose / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D010101:Oxygen Consumption; D011467:Prostate / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D000085:Acetates; D000728:Androgens; D002951:Citrates; D002245:Carbon Dioxide; D019343:Citric Acid; D005947:Glucose