title: Vasopressin: action on WRK-1 rat mammary tumor cells.
abstract: WRK-1, a cell line in long-term culture derived from a 7, 12-dimethylbenz[a]anthracene-induced rat mammary tumor, responds to physiologic concentrations of vasopressin with increased precursor incorporation into phospholipids and with increased protein accumulation. Because vasopressin has been reported to be a potent mitogen for Hela cells and 3T3 cells, a study was conducted to determine whether it could act as a mitogen for WRK-1 cells. Under no conditions was a clear-cut mitogen response to vasopressin demonstrated.
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D001551:Benz(a)Anthracenes; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy*; D008934:Mitogens / Q000494:pharmacology; D051381:Rats; D014667:Vasopressins / Q000494:pharmacology*
chemical_list: D001551:Benz(a)Anthracenes; D008934:Mitogens; D014667:Vasopressins; D015127:9,10-Dimethyl-1,2-benzanthracene