title: Chemical phlebothrombosis of large veins. A not uncommon complication of total parenteral nutrition.
abstract: Thrombosis of large veins during total parenteral nutrition (TPN) is considered uncommon. Recently, clinical and phlebographic evidence of large-vein thrombosis were encountered in five patients among 200 consecutive patients receiving TPN. The symptoms, signs, and phlebographic findings occurred within one to two days, sometimes as early as a few hours after cannulation. It is suggested that thrombosis of large veins during TPN is not uncommon and is the result of chemical phlebothrombosis due to a hypersensitivity reaction of the venous wall to the polyvinyl catheter material. Early removal of the offending catheter is advocated.
mesh_terms: D000293:Adolescent; D000328:Adult; D002404:Catheterization / Q000009:adverse effects*; D002648:Child; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D010288:Parenteral Nutrition; D010289:Parenteral Nutrition, Total; D011145:Polyvinyls / Q000009:adverse effects*; D011859:Radiography; D013350:Subclavian Vein; D013924:Thrombophlebitis / Q000139:chemically induced* / Q000000981:diagnostic imaging
chemical_list: D011145:Polyvinyls