Antimutagenic effect of selenium on acridine orange and 7,12-dimethylbenz[alpha]anthracene in the Ames Salmonella/microsomal system.
The antimutagenic effects of selenium as sodium selenite were investigated using the Ames Salmonella/microsome mutagenicity test. The compounds examined were acridine orange and 7,12-dimethylbenz[alpha]anthracene. Selenium (22 ppm) reduced the number of histidine revertants caused by 20 microgram acridine orange and 20 microgram 7,12-dimethylbenz[alpha]anthracene by 52 and 74%, respectively. Increasing the quantity of selenium added to the plates further suppressed the mutagenicity of the test compounds. The antimutagenic effects of selenium cannot be explained by lethality of Salmonella typhimurium.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors*; D000165:Acridine Orange / Q000037:antagonists & inhibitors*; D001551:Benz(a)Anthracenes / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D009152:Mutagenicity Tests; D009154:Mutation / Q000187:drug effects*; D012486:Salmonella typhimurium / Q000235:genetics; D012643:Selenium / Q000494:pharmacology*
D001551:Benz(a)Anthracenes; D015127:9,10-Dimethyl-1,2-benzanthracene; D000165:Acridine Orange; D012643:Selenium