title: Natural tolerance: a model for Ir gene effects in the cytotoxic T cell response to H-Y.
abstract: It is proposed that T cell nonresponsiveness to H-Y is attributable to natural tolerance, maintained in the periphery by an anti-idiotype suppressor mechanism. Induction of such a suppressor mechanism occurs when H-Y plus certain K or D antigens mimic other self-alleles of K or D antigens either alone or in conjunction with minor histocompatibility antigens. The application of the model to other systems, as well as predictions made from it are discussed.
mesh_terms: D000818:Animals; D003602:Cytotoxicity, Immunologic; D005802:Genes, MHC Class II; D006182:H-Y Antigen / Q000235:genetics / Q000276:immunology*; D007108:Immune Tolerance; D051379:Mice; D008954:Models, Biological; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D006182:H-Y Antigen