[DNA damage after treatment in-vivo with several aromatic amines: 2,4-diaminotoluene, 4-aminobenzene (aniline) and paradimethylaminoazobenzene (butter yellow)].
Three aromatic amines, 2,4 diaminotoluene, aminobenzene and paradimethylaminoazobenzene were examined for their capability of damaging rat liver DNA. Compounds were tested by the "in vivo"/DNA alcaline elution assay. 2,4 diaminotoluene was very positive, aminobenzene weakly positive, paradimethylaminoazobenzene probably negative. All the compounds were tested at doses already clearly toxic.
D000814:Aniline Compounds / Q000009:adverse effects*; D000818:Animals; D004247:DNA; D008099:Liver / Q000187:drug effects*; D008113:Liver Neoplasms / Q000139:chemically induced; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010655:Phenylenediamines / Q000009:adverse effects*; D051381:Rats; D004124:p-Dimethylaminoazobenzene / Q000009:adverse effects*
D000814:Aniline Compounds; D010655:Phenylenediamines; D004247:DNA; D004124:p-Dimethylaminoazobenzene; C010914:2,4-diaminotoluene; C023650:aniline
Danno al DNA, dopo tratamento "in vivo" con alcune ammine aromatiche: 2-4 diamminotoluene, 4 amminobenzene (anilina) e paradimetilamminoazobenzene (giallo burro).