Vasodilator therapy in refractory congestive heart failure: a comparative analysis of hemodynamic and noninvasive studies.
The response to vasodilator therapy was assessed in 12 patients with chronic severe congestive heart failure refractory to conventional treatment. Cardiac output and intraarterial and pulmonary capillary wedge pressures were recorded continuously to assess the hemodynamic response to the vasodilators used. Control and post-treatment M mode echocardiograms and radionuclide angiograms were obtained to assess the change in left ventricular size and ejection fraction concurrent with the hemodynamic improvement. Despite a 33 percent decrease in pulmonary capillary wedge pressure (p less than 0.001) and a 35 percent increase in cardiac index (p less than 0.001), no significant change occurred in left ventricular end-diastolic or end-systolic chamber size on echocardiography or in ejection fraction measured with radionuclide angiography. In this study M mode echocardiography and radionuclide angiography were of no value in monitoring the actual hemodynamic response to vasodilator therapy in this group of patients with a left ventricular ejection fraction of less than 30 percent.
D000368:Aged; D002302:Cardiac Output; D004341:Drug Evaluation; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000188:drug therapy*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D006830:Hydralazine / Q000627:therapeutic use; D007548:Isosorbide Dinitrate / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D005996:Nitroglycerin / Q000627:therapeutic use; D009823:Ointment Bases; D011224:Prazosin / Q000627:therapeutic use; D011669:Pulmonary Wedge Pressure; D013318:Stroke Volume; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
D009823:Ointment Bases; D014665:Vasodilator Agents; D006830:Hydralazine; D005996:Nitroglycerin; D007548:Isosorbide Dinitrate; D011224:Prazosin