Inhibition of diamine oxidase by antimalarial drugs.
The antimalarial drugs amodiaquine, quinacrine and chloroquine inhibit the catabolism of putrescine by the rat. Amodiaquine, the most potent of the three, does so in a dose-dependent fashion. This is attributed to the action in vivo of the drugs on diamine oxidase, an enzyme that is inhibited by them in vitro.
D006631:Amine Oxidase (Copper-Containing) / Q000037:antagonists & inhibitors*; D000655:Amodiaquine / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002738:Chloroquine / Q000494:pharmacology; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000201:enzymology; D008297:Male; D011700:Putrescine / Q000378:metabolism; D011796:Quinacrine / Q000494:pharmacology; D051381:Rats
D000962:Antimalarials; D000655:Amodiaquine; D002738:Chloroquine; D006631:Amine Oxidase (Copper-Containing); D011796:Quinacrine; D011700:Putrescine