[Preliminary reports on homologous and heterologous intercellular adhesion in normal and neoplastic cells cultured in vitro].
In our researches on the molecular meccanisms of cellular adhesion and density dependence inhibition we observed the SGS-3A neoplastic cells show a cell-cell adhesion higher than the homogenetic fibroblasts. This adhesion increases in single cells prepared with EDTA rather than Trypsin. Specific and non specific intercellular adhesion assays demonstrate that ligand molecules of coat of neoplastic cells are strongly trypsin-sensitive; on the contrary ligand molecules of coat of fibroblasts are more trypsin-resistent.
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002452:Cell Count; D002478:Cells, Cultured; D004492:Edetic Acid / Q000494:pharmacology; D005347:Fibroblasts / Q000166:cytology; D051381:Rats; D012513:Sarcoma, Experimental / Q000473:pathology*; D014357:Trypsin / Q000494:pharmacology
D004492:Edetic Acid; D014357:Trypsin
Ricerche preliminari sull'adesione intercelluare omologa ed eterologa in cellule normali e neoplastiche coltivate "in vitro".