title: Gastric secretory and plasma hormonal responses to sham-feeding of varying duration in patients with duodenal ulcer.
abstract: Gastric acid and serum gastrin, pancreatic polypeptide, and insulin responses to cephalic vagal stimulation were studied in eight patients with duodenal ulcer using modified sham-feeding for periods varying from four to 30 minutes. In addition, the maximal acid response to sham-feeding was compared with that induced by pentagastrin in 10 healthy subjects and 14 patients with duodenal ulcer. It was found that the gastric acid response to modified sham-feeding reached the maximal value after 15 minutes of sham-feeding and amounted to about 68% of the pentagastrin maximum. The serum pancreatic polypeptide response was also increased after modified sham-feeding and depended on the duration of this procedure, whereas gastrin and insulin responses were not significantly affected by modified sham-feeding. When the peak acid output induced by modified sham-feeding was normalised as percentage of the peak response to pentagastrin, it was similar in healthy subjects and in patients with duodenal ulcer; this indicates that the increased peak acid response to modified sham-feeding observed in patients with duodenal ulcer corresponded with their greater parietal cell mass rather than with increased vagal tone.
mesh_terms: D000328:Adult; D004381:Duodenal Ulcer / Q000097:blood / Q000503:physiopathology*; D004435:Eating; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D006728:Hormones / Q000097:blood*; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D010191:Pancreatic Polypeptide / Q000097:blood; D010418:Pentagastrin; D010434:Pepsin A / Q000378:metabolism*; D013997:Time Factors
chemical_list: D005755:Gastrins; D006728:Hormones; D007328:Insulin; D010191:Pancreatic Polypeptide; D010434:Pepsin A; D010418:Pentagastrin