Resin hemoperfusion for unconjugated bilirubin removal.
The application of an anionic macroreticular ion exchange resin, coated with a thin cross-linked albumin layer, as a hemoperfusion device for the removal of unconjugated bilirubin from the blood of hyperbilirubinemic newborn babies is reviewed. In vivo hemoperfusion runs with hyperbilirubinemic animal models - either by a choledocho-suprarenal vein shunt or by direct infusion of bilirubin into the vein - showed that a 40-ml resin column can remove some 20 mg bilirubin in 3 h. Hemoperfusion of female 8-14 kg baboons showed no significant effect of the column on blood chemistry and coagulation factors and repeated runs had no ill effects.
D000327:Adsorption; D000418:Albumins / Q000627:therapeutic use; D000818:Animals; D001663:Bilirubin / Q000097:blood*; D004285:Dogs; D005260:Female; D005976:Glutaral / Q000494:pharmacology; D006439:Hemodynamics; D006464:Hemoperfusion; D006493:Heparin / Q000627:therapeutic use; D006501:Hepatic Encephalopathy / Q000188:drug therapy*; D006863:Hydrogen-Ion Concentration; D006932:Hyperbilirubinemia / Q000188:drug therapy / Q000209:etiology; D007475:Ion Exchange Resins / Q000627:therapeutic use*; D010215:Papio
D000418:Albumins; D007475:Ion Exchange Resins; D006493:Heparin; D001663:Bilirubin; D005976:Glutaral