Immunoglobulin allotypes and immune response to meningococcal polysaccharides A and C.
Serum samples were collected from 113 healthy Caucasian volunteers before and after vaccination with meningococcal polysaccharides (MPS) group A and group C. Antibodies to MPS group A and group C were measured and sera were typed for several Gm and Km(1) allotypes. A significant association was found between the Gm 1,3,17; 5,13,14,21 phenotype and low immune responsiveness to MPS group A. These results suggest the possible existence of an immunoglobulin allotype-linked immune suppression (Is) gene(s) in man.
D000328:Adult; D000907:Antibodies, Bacterial / Q000235:genetics / Q000276:immunology*; D000917:Antibody Formation; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007114:Immunization; D007126:Immunoglobulin Allotypes / Q000235:genetics / Q000276:immunology*; D007165:Immunosuppression Therapy; D009345:Neisseria meningitidis / Q000276:immunology; D011135:Polysaccharides, Bacterial / Q000276:immunology*
D000907:Antibodies, Bacterial; D007126:Immunoglobulin Allotypes; D011135:Polysaccharides, Bacterial