title: Minimum amount of penicillin prophylaxis required to control Streptococcus pyogenes epidemic in closed community.
abstract: The prophylaxis required to control an epidemic of Streptococcus pyogenes throat infection in a junior detention centre has been reported. In a further epidemic an attempt was made to determine the minimum amount of penicillin required to control the outbreak. Oral penicillin (0.5 g) given as a single daily dose for 10 days to all boys after entry proved effective. The added risk of  relatively deprived adolescent boys developing rheumatic fever is stressed.
mesh_terms: D000293:Adolescent; D004196:Disease Outbreaks / Q000517:prevention & control*; D004334:Drug Administration Schedule; D004739:England; D006801:Humans; D008297:Male; D010404:Penicillin V / Q000008:administration & dosage*; D011330:Prisons; D013290:Streptococcal Infections / Q000453:epidemiology / Q000517:prevention & control*; D013297:Streptococcus pyogenes; D014069:Tonsillitis / Q000453:epidemiology / Q000517:prevention & control*
chemical_list: D010404:Penicillin V