title: Chemical impurity produces extra compound eyes and heads in crickets.
abstract: A chemical impurity isolated from commercially purchased acridine causes cricket embryos to develop extra compound eyes, branched antennae, extra antennae, and extra heads. Purified acridine does not produce similar duplications of cricket heads or head structures nor do the substituted acridines proflavine, acriflavine, or acridine orange. A dose-response relation exists such that the number and severity of abnormalities increase with increasing concentration of the teratogen.
mesh_terms: D000015:Abnormalities, Multiple / Q000139:chemically induced; D000166:Acridines / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004340:Drug Contamination; D004625:Embryo, Nonmammalian / Q000187:drug effects; D005124:Eye Abnormalities; D006257:Head / Q000002:abnormalities; D009987:Orthoptera / Q000187:drug effects*; D013723:Teratogens
chemical_list: D000166:Acridines; D013723:Teratogens