Effects of Syphacia muris and the anthelmintic fenbendazole on the microsomal monooxygenase system in mouse liver.
Mice given food containing fenbendazole to prevent a reinfection with Syphacia muris were treated with inducers of the hepatic microsomal monooxygenase system. Specific induction values and factors were the same as found previously in similar mice infected with Syphacia muris. There was a decrease in the total hepatic monooxygenase system by 20-40%, associated with a similar decrease in the total microsomal protein. As this was found in both experimental and control mice, the induction factors of the total values remained also unaltered. Thus infection by Syphacia muris not only retarded the growth of young mice but also accelerated the development of their hepatic monooxygenase system.
D000818:Animals; D000830:Animals, Laboratory; D001562:Benzimidazoles / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004032:Diet; D005260:Female; D005273:Fenbendazole / Q000494:pharmacology* / Q000627:therapeutic use; D005503:Food Additives; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D010123:Oxyuriasis / Q000517:prevention & control; D010124:Oxyuroidea / Q000187:drug effects* / Q000254:growth & development; D014468:Umbelliferones / Q000378:metabolism
D001562:Benzimidazoles; D005503:Food Additives; D014468:Umbelliferones; D005273:Fenbendazole; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; C020131:ethylumbelliferone dealkylase; D009251:NADPH-Ferrihemoprotein Reductase