Blockade of the inflammatory effects of platelet-activating factor by cyclo-oxygenase inhibitors.
1. The edematogenic and hyperalgesic effects of synthetic Platelet-Activating Factor (PAF-acether) on the rat paw were investigated. 2. PAF-acether induced a dose-dependent oedema and hyperalgesia. 3. These effects were partially reduced by non-steroidal anti-inflammatory agents. 4. It is suggested that the oedema and hyperalgesia in response to PAF-acether are due at least in part to the release of a cyclo-oxygenase metabolite, probably prostacyclin.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D002351:Carrageenan / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors; D004487:Edema / Q000139:chemically induced; D006930:Hyperalgesia / Q000139:chemically induced; D007213:Indomethacin / Q000494:pharmacology; D008244:Lysophosphatidylcholines / Q000009:adverse effects / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D010972:Platelet Activating Factor; D051381:Rats
D016861:Cyclooxygenase Inhibitors; D008244:Lysophosphatidylcholines; D010972:Platelet Activating Factor; D002351:Carrageenan; D001241:Aspirin; D007213:Indomethacin