[Disturbances of chemotaxis in protein-calorie malnutrition (author's transl)].
A study of specific and non-specific immune functions was performed in 14 children presenting with severe malnutrition, before and after parenteral hyperalimentation by central catheter. Anomalies of cellular functions (reduction of the percentage of E rosettes and deficient proliferation with mitogens) were rarely found. Measurements for serum immunoglobulins did not show any anomaly; however reduced percentages of EAC rosettes and important increase in "null" cells were found in about one third of the cases. The main finding was a decreased serum chemotactic activity following activation of the classic complement pathway. This was found in 12 children and returned to normal values in all cases after hyperalimentation.
D002630:Chemotactic Factors / Q000096:biosynthesis*; D002634:Chemotaxis, Leukocyte; D006098:Granulocytes; D006801:Humans; D007223:Infant; D007958:Leukocyte Count; D010289:Parenteral Nutrition, Total; D011502:Protein-Energy Malnutrition / Q000276:immunology* / Q000628:therapy; D012397:Rosette Formation
D002630:Chemotactic Factors
Les troubles du chimiotactisme dans la malnutrition protéino-énergétique.