title: Cytophotometric and cytogenetic characteristics of primary hepatomas induced in Wistar rats by aflatoxin B1.
abstract: Karyograms of the primary hepatomas induced in Wistar rats by aflatoxin b1 exhibited hypodiploid chromosome sets, and destruction of the chromosomes. Cytophotometric investigations showed a decrease of DNA content in the neoplastic cells, even to about 40% of DNA content in the normal hepatocytes in rats. In the neoplastic destruction of the chromatin material in these hepatomas breaks and deletion of the chromatids predominate.
mesh_terms: D016604:Aflatoxin B1; D000818:Animals; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000032:analysis; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000235:genetics* / Q000473:pathology; D051381:Rats; D000096702:Aflatoxin Poisoning
chemical_list: D016604:Aflatoxin B1; D004273:DNA, Neoplasm