Light-chain nephropathy in patient with renal carcinoma.
Paraneoplastic syndromes are often associated with renal parenchymal tumours. This report describes a case of renal-cell carcinoma with kappa-chain nephropathy. The patient, a 60-year-old man, had renal tubular dysfunction, shown by low serum concentrations of urate and phosphate. Kappa-chains were found in both serum and urine, but no lambda-chains were found. Investigations showed a clear-cell carcinoma, and the patient underwent a radical nephrectomy. Two years after operation serum phosphate and urate concentrations had returned to normal, and kappa-chains were undetectable in serum or urine. The absence of lambda-chains indicates that the light-chain proteinuria was due to overproduction of the M component, and the disappearance of kappa-chains after the operation suggests a causal relation between the renal tumour and the overproduction of the M component.
D000230:Adenocarcinoma / Q000150:complications* / Q000276:immunology; D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology*; D007147:Immunoglobulin Light Chains / Q000032:analysis; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains / Q000032:analysis / Q000652:urine; D007674:Kidney Diseases / Q000209:etiology*; D007680:Kidney Neoplasms / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged
D007147:Immunoglobulin Light Chains; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains