Control of canine renin release: macula densa requires prostaglandin synthesis.
1. The macula densa mechanism of renin release was functionally isolated in uninephrectomized, anaesthetized dogs by producing renal denervation, beta-adrenoceptor blockade, and maximum renal vasodilation with an infusion of papaverine into the renal artery. 2. A suprarenal aortic clamp was adjusted to reduce renal perfusion pressure by 50% which resulted in a 90% reduction in urinary sodium excretion and a two to threefold increase in plasma renin activity within 10 min. 3. Indomethacin (8 mg/kg) or meclofenamic acid (10 mg/kg) inhibited the rise plasma renin activity produced by the decrease in renal perfusion pressure in this model, although a comparable decrease in urinary sodium excretion was achieved. 4. We conclude that the macula densa mechanism of renin release is blocked by inhibition of prostaglandin synthesis.
D000818:Animals; D016861:Cyclooxygenase Inhibitors; D004285:Dogs; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D007684:Kidney Tubules / Q000378:metabolism*; D007686:Kidney Tubules, Distal / Q000378:metabolism*; D008297:Male; D008469:Meclofenamic Acid / Q000494:pharmacology; D009318:Natriuresis / Q000187:drug effects; D011453:Prostaglandins / Q000096:biosynthesis*; D012083:Renin / Q000097:blood*
D016861:Cyclooxygenase Inhibitors; D011453:Prostaglandins; D008469:Meclofenamic Acid; D012083:Renin; D007213:Indomethacin