Partition coefficients of some aromatic alcohols in an n-heptane/water system and their relationship to minimum inhibitory concentration against Pseudomonas aeruginosa and Staphylococcus aureus.
The partition coefficients of the homologous series of aromatic alcohols were determined in an n-heptane/water system. The minimum inhibitory concentrations of benzyl alcohol, 2-phenylethanol, 3-phenylpropanol, 4-phenylbutanol and 5-phenylpentanol were elucidated against Pseudomonas aeruginosa and Staphylococcus aureus. The linear relationship log1/C = a log P + b postulated by Hansch was found to apply.
D000438:Alcohols / Q000494:pharmacology*; D006536:Heptanes; D008826:Microbial Sensitivity Tests; D011550:Pseudomonas aeruginosa / Q000187:drug effects*; D012995:Solubility; D013211:Staphylococcus aureus / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014867:Water
D000438:Alcohols; D006536:Heptanes; D014867:Water; C028618:n-heptane