[Effect of vitamin D on skin metabolism (author's transl)].
To examine for a possible local action of vitamin D on skin, its histology DNA content, melanogenetic response to UV and proliferative activity (incorporation of 3H thymidine into DNA) were studied on vitamin D deficient and vitamin D fed rats. The skin thickness DNA content and melanogenetic response to UV (assessed as the activity of skin tyrosinase) were greater in vitamin D fed than in vitamin deficient rats. In keratinocyte cell cultures vitamin D (10-9 M-10-12 M) increased DNA synthesis in suprabasal cells whereas it had no effect on DNA synthesis in basal cells. The influence of vitamin D on skin thickness and melanogenetic response to UV could provide an effective feed-back control for protection against UV penetration and vitamin D intoxication.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000378:metabolism*; D004261:DNA Replication / Q000187:drug effects; D014442:Monophenol Monooxygenase / Q000378:metabolism; D051381:Rats; D012867:Skin / Q000187:drug effects / Q000528:radiation effects; D012879:Skin Physiological Phenomena; D014466:Ultraviolet Rays; D014807:Vitamin D / Q000494:pharmacology*; D014808:Vitamin D Deficiency / Q000378:metabolism*
D014807:Vitamin D; D004247:DNA; D014442:Monophenol Monooxygenase
Etude de l'activité biologique de la vitamine D sur l'épiderme.