Use of alpha-methylphenylalanine for studies of brain development in experimental phenylketonuria.
Experimental phenylketonuria was induced in newborn rats by administration of L-phenylalanine and alpha-methylphenylalanine. There was no primary disturbance of myelination, but reduced cell proliferation, early cell death and compensatory hyperplasia were evident in the cerebellum.
D000818:Animals; D001921:Brain / Q000254:growth & development*; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002531:Cerebellum / Q000166:cytology*; D004195:Disease Models, Animal; D006801:Humans; D010649:Phenylalanine / Q000031:analogs & derivatives* / Q000494:pharmacology; D010651:Phenylalanine Hydroxylase / Q000037:antagonists & inhibitors; D010661:Phenylketonurias / Q000139:chemically induced / Q000473:pathology*; D051381:Rats
C012436:alpha-methylphenylalanine; D010649:Phenylalanine; D010651:Phenylalanine Hydroxylase