title: Amplification of the tetracycline resistance determinant of plasmid pAM alpha 1 in Streptococcus faecalis: dependence on host recombination machinery.
abstract: The plasmid pAM alpha 1 in Streptococcus faecalis was found to be severely impaired in its ability to exhibit amplification (generation of tandem repeats of the tetracycline resistance determinant during extended growth in the presence of tetracycline) when harbored by the recombination-deficient host cell UV202.
mesh_terms: D013293:Enterococcus faecalis / Q000187:drug effects / Q000235:genetics*; D005784:Gene Amplification; D011815:R Factors; D011995:Recombination, Genetic; D013752:Tetracycline
chemical_list: D013752:Tetracycline