Effect of chain length of short-chain fatty acids on their effect on intracranial pressure in rabbits.
The short-chain fatty acids propionic, butyric, valeric, isovaleric and octanoic produced elevations in intracranial pressure during intravenous infusion in rabbits. Serum concentrations of these compounds are elevated in patients with Reye's syndrome, and may contribute to the intracranial pressure elevations found in these patients.
D000818:Animals; D002245:Carbon Dioxide / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005232:Fatty Acids, Volatile / Q000097:blood / Q000494:pharmacology*; D007263:Infusions, Parenteral; D007427:Intracranial Pressure / Q000187:drug effects*; D008297:Male; D010100:Oxygen / Q000097:blood; D011817:Rabbits
D005232:Fatty Acids, Volatile; D002245:Carbon Dioxide; D010100:Oxygen