title: 3-(2,6-Xylyl)-5-methylhydantoin--a metabolite or a metabonate of tocainide in rats.
abstract: 1. G.1.c.-mass spectrometric analysis of urine extracts from rats dosed with tocainide (I) revealed the presence of cyclic compound identified as 3-(2,6-xylyl)-5-methylhydantoin (IV) derived from tocainide. 2. Evidence indicates that IV is derived from a conjugate of tocainide (tocainide carbonyl O-beta-D-glucuronide) (III) in humans. 3. Results of the present study indicate that in addition to being formed from a conjugate, IV is generated directly from tocainide in vivo in rats. Possible mechanisms for the formation of IV in rats in vivo are discussed.
mesh_terms: D000818:Animals; D001711:Biotransformation; D004355:Drug Stability; D006827:Hydantoins / Q000378:metabolism*; D008012:Lidocaine / Q000031:analogs & derivatives* / Q000378:metabolism; D008297:Male; D051381:Rats; D016677:Tocainide
chemical_list: D006827:Hydantoins; D016677:Tocainide; C031395:3-(2,6-xylyl)-5-methylhydantoin; D008012:Lidocaine