Indicators of developmental toxicity following prenatal administration of hormonally active compounds in the rat. II. Pattern of maternal weight gain.
Chronic prenatal exposure of rats to diethylstilbestrol, zeranol, or 3,4,3',4'-tetrachlorobiphenyl produced quantitative and qualitative differences in the cumulative pattern of weight gain during pregnancy. Each of the three compounds, however, exhibited unique characteristics with respect to the effect of increased dose on this response, as well as in the relationship of reduced weight gain to perinatal mortality. The weight deficit after diethylstilbestrol treatment was found to reside in the dam herself, not in any compartment of the gravid uterus. The pattern of maternal weight gain is a useful indicator of developmental toxicity permitting discrimination among structurally diverse chemical agents.
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004054:Diethylstilbestrol / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005313:Fetal Death / Q000139:chemically induced; D005333:Fetus / Q000033:anatomy & histology; D009929:Organ Size / Q000187:drug effects; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D011919:Rats, Inbred Strains; D012118:Resorcinols / Q000633:toxicity*; D014599:Uterus / Q000033:anatomy & histology; D015029:Zeranol / Q000633:toxicity*
D012118:Resorcinols; D004054:Diethylstilbestrol; D015029:Zeranol; D011078:Polychlorinated Biphenyls; C028451:3,4,3',4'-tetrachlorobiphenyl