[Bioactive "enteroglucagon" (oxyntomodulin): evidence for a C-terminal extension of the glucagon molecule].
The bioactive fraction of "enteroglucagon" has been isolated from the porcine jejuno-ileum on the basis of its glucagon-like action in liver. High performance liquid chromatography analysis followed by Dansylation of peptide fragments obtained after enzymatic digestion of both this peptide and glucagon suggests that the bioactive "enteroglucagon" contains the glucagon molecule plus a C-terminal extension under the from of the octapeptide. Lys-Arg-Asn-Lys-Asn-Asn-Ile-Ala-COOH. The presence in the native molecular of a structural difference of modification as compared to glucagon in the 1-11 fragment is possible.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000032:analysis; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005768:Gastrointestinal Hormones / Q000032:analysis*; D005934:Glucagon / Q000032:analysis; D004763:Glucagon-Like Peptides / Q000032:analysis*; D006639:Histidine; D007082:Ileum / Q000032:analysis; D007583:Jejunum / Q000032:analysis; D053772:Oxyntomodulin; D010446:Peptide Fragments / Q000032:analysis; D013552:Swine
D000596:Amino Acids; D005768:Gastrointestinal Hormones; D053772:Oxyntomodulin; D010446:Peptide Fragments; D006639:Histidine; D004763:Glucagon-Like Peptides; D005934:Glucagon
"Entéroglucagon" bioactif (oxyntomoduline) : évidence pour une extension C-terminale de la molécule de glucagon.