Clinical findings and immunochemical studies in a patient with cryoglobulinaemia.
Purpura, shallow ulcers, and livedo were noted in a patient with IgG3-kappa cryoglobulinaemia. The IgG3 cryoglobulin reacted with all IgG subclasses. No complement activation could be demonstrated in fresh normal serum, almost complete conversion of C3, but not of factor B occurred.
D000368:Aged; D003167:Complement Activation; D003165:Complement System Proteins / Q000032:analysis; D003450:Cryoglobulins / Q000302:isolation & purification*; D006801:Humans; D007074:Immunoglobulin G / Q000302:isolation & purification*; D007147:Immunoglobulin Light Chains / Q000302:isolation & purification*; D007145:Immunoglobulin kappa-Chains / Q000302:isolation & purification*; D008297:Male; D010265:Paraproteinemias / Q000276:immunology* / Q000473:pathology; D012867:Skin / Q000473:pathology
D003450:Cryoglobulins; D007074:Immunoglobulin G; D007147:Immunoglobulin Light Chains; D007145:Immunoglobulin kappa-Chains; D003165:Complement System Proteins