DNA repair in human fibroblasts treated with a combination of chemicals.
Excision repair of DNA damage was measured by the photolysis of bromodeoxy-uridine incorporated during repair in normal human and xeroderma pigmentosum group C fibroblasts (XP C) treated with a combination of the carcinogens N-acetoxy-2-acetylamino-fluorene (AAAF), and 4-nitroquinoline 1-oxide (4NQO). Repair was additive in normal and XP C cells treated with AAAF plus 4NQO, indicating that there are different rate limiting steps for removal of 4NQO and AAAF lesions.
D015073:2-Acetylaminofluorene / Q000031:analogs & derivatives*; D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology*; D000099:Acetoxyacetylaminofluorene / Q000494:pharmacology*; D004260:DNA Repair / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000502:physiology*; D006801:Humans; D009600:Nitroquinolines / Q000494:pharmacology*; D010782:Photolysis
D009600:Nitroquinolines; D015112:4-Nitroquinoline-1-oxide; D000099:Acetoxyacetylaminofluorene; D015073:2-Acetylaminofluorene