[Localization, in the D region of the major histocompatibility complex, of the genes controlling the level of killer T-cell mediated antiviral response through the phenomenon of restriction by H-2 antigens].
In two different murine systems it is shown that immune response genes, mapping to the D region of the major histocompatibility complex, control the level of the immune response mediated by cytolytic T lymphocytes and specific for the virus induced FMR antigens. The high responder phenotype is dominant. It is associated with the choice of certain H-2 antigens as restricting factors of the T lymphocyte activity, histocompatibility antigens behaving like Ir gene products.
D000818:Animals; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics / Q000276:immunology*; D007111:Immunity, Cellular; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D014777:Virus Diseases / Q000276:immunology
D006183:H-2 Antigens
Localisation dans la région D du complexe majeur d'histocompatibilité de gènes contrôlant le niveau de réponse T tueuse antivirale à travers le phénomène de restriction par les antigènes H-2.