Urinary tract infection after injection of pseudomonas into bladder.
Pseudomonas urinary tract infection was studied in female mice. The bladder was exposed by a lower midline incision and an overnight washed culture of Pseudomonas (0.05 ml.) was injected into the bladder. This resulted in infection of the kidneys in more than 50 per cent of mice at one week. At four hours, the microulceration of the bladder was observed with many Pseudomonas int the base of the ulcer. The presence of acute inflammation on the serosal surface of the bladder, the frequent death of the mice, the presence of cortical foci of polymorphonuclear leukocytes in the kidneys, and bacteremia suggested that bacteremia may play a significant role in the development of the renal infection in this model of urinary tract infection. Bacteria injected through the bladder wall of mice cannot be assumed to produce ascending infection of the kidney.
D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D007674:Kidney Diseases / Q000382:microbiology / Q000473:pathology; D051379:Mice; D011552:Pseudomonas Infections / Q000382:microbiology; D011550:Pseudomonas aeruginosa; D018805:Sepsis / Q000382:microbiology; D001745:Urinary Bladder Diseases / Q000382:microbiology / Q000473:pathology; D014552:Urinary Tract Infections / Q000382:microbiology* / Q000473:pathology