Genetic control of the immune response to haemoglobin. IV. Ly-1+ T-cells and appropriate non-H-2 genes are required for in vitro responses to alpha- and beta-subunits of human adult haemoglobin.
Experiments were conducted to determine if non-H2 gene effects could be demonstrated in mice which had been primed to either the alpha-subunit or beta-subunit of human haemoglobin. It was found that C3H.SW (H-2b) and Balb/c (H-2d) mice are low responder mice to alpha-chain of a haemoglobin when compared to H-2 identical B10 (H-2b) and B10.D2(H-2d) mice. B120.S and A.SW (both H-2s) are responsive to beta-chain challenge while Balb/c mice are low responders in contrast to high responder B10.D2 mice. Ly-1+ cells were demonstrated to be required (by cell depletion experiments) for an in vitro T-cell proliferative response to either subunit. In these experiments, Ly-2+ cells were not of crucial importance.
D000818:Animals; D000950:Antigens, Ly / Q000235:genetics*; D005802:Genes, MHC Class II; D006183:H-2 Antigens / Q000235:genetics; D006441:Hemoglobin A / Q000235:genetics / Q000276:immunology; D006454:Hemoglobins / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology*
D000950:Antigens, Ly; D006183:H-2 Antigens; D006454:Hemoglobins; D006441:Hemoglobin A