[Permissive effects of human colonic cancer (HT-29 and Caco-2) on intestinal smooth muscle differentiation].
Human colonic carcinoma cells (lines HT-29 and Caco-2) were associated with 5 1/2 day-old chick embryonic intestinal mesenchyme and grafted for 11 days into 3 day-old Chick embryos. In these conditions, the cancer cells exert on the mesenchyme a supportative effect leading to its differentiation into muscular layers. The results provide additional evidence that HT-29 and Caco-2 cells exhibit common properties to fetal and normal intestinal cells.
D000818:Animals; D002454:Cell Differentiation; D002460:Cell Line; D002478:Cells, Cultured; D002642:Chick Embryo; D003110:Colonic Neoplasms / Q000503:physiopathology*; D007422:Intestines / Q000502:physiology; D009130:Muscle, Smooth / Q000166:cytology / Q000502:physiology*
Effet permissif des cellules cancéreuses coliques humaines (HT-29 et Caco-2) sur la différenciation du muscle lisse intestinal.