Influence of 2 mg estradiol-17 beta on circulating FSH, LH, total and unconjugated estradiol levels in post-menopausal women.
The 24-hour variation in total and unconjugated serum estradiol-17 beta as well as the daily variation in one-hour serum concentration values of FSH and LH have been examined in 9 post-menopausal women given 2 mg tablets of estradiol-17 beta daily for 14 days. The tablets were manufactured according to a new dispersion method aiming at producing essentially smaller crystals, thereby enhancing the bioavailability of the estradiol-17 beta. In comparison with other preparations, this one provides a more rapid absorption, reaching peak effect after only 1 or 2 hours and presenting a higher peak than has been found with any of the others. The elimination from serum combines a rapid initial phase followed by a very slow one. Thus serum levels of estradiol-17 beta 24 hours after administration are significantly higher than the levels measured before administration of the first tablet. A rather small but significant reduction in serum LH and FSH was observed on the third and subsequent treatment days.
D000368:Aged; D004958:Estradiol / Q000097:blood / Q000494:pharmacology*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood*; D008593:Menopause; D008875:Middle Aged; D013607:Tablets
D013607:Tablets; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone