title: Differential cytotoxicity of cytosine arabinoside toward murine leukemia L1210 cells and murine bone marrow progenitor cells inhibited in nucleoside transport by cimicifugoside.
abstract: Cytotoxicities of cytosine arabinoside (Ara C) and showdomycin to murine L1210 leukemia cells was prevented by a nucleoside transport inhibitor, cimicifugoside. Ara C toxicity to bone marrow progenitor cells, however, was observed even in the presence of cimicifugoside. The difference of Ara C toxicity toward L1210 cells and bone marrow cells pretreated with cimicifugoside may be originated in the different characteristics of membrane transport site of nucleosides.
mesh_terms: D000818:Animals; D001854:Bone Marrow Cells; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003561:Cytarabine / Q000633:toxicity*; D006026:Glycoside Hydrolases / Q000494:pharmacology*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D007810:Lanosterol / Q000031:analogs & derivatives* / Q000494:pharmacology; D007939:Leukemia L1210 / Q000503:physiopathology*; D051379:Mice; D009705:Nucleosides / Q000378:metabolism; D012787:Showdomycin / Q000494:pharmacology; D014995:Xylosidases / Q000494:pharmacology*
chemical_list: D009705:Nucleosides; D003561:Cytarabine; D007810:Lanosterol; C031436:cimicifugoside; D012787:Showdomycin; D006026:Glycoside Hydrolases; D014995:Xylosidases