title: [Absorption of isosorbide dinitrate in guinea-pig intestine and in the colon of sheep (author's transl)].
abstract: Segments of the intestine of anaesthetized guinea-pigs and the colon of conscious sheep were perfused with saline containing 0.1--25 mg/l 1,4:3,6-dianhydrosorbitol-2,5-dinitrate (isosorbide dinitrate, ISDN). The increase in ISDN uptake was linearly related to its concentration. Absorption was rapid. In the jejunum and the ileum of guinea-pig, 7% of perfused ISDN was absorbed per 10 cm of intestine in the proximal and 15% in the distal colon, respectively. In the total colon of sheep, 83% disappeared during the perfusion. Per unit of length, surface or dry weight of mucosa the net flux of ISDN in the small intestine was only half that in the colon. Absorption from the colon per unit of wet weight of the gut was only slightly higher compared to the small intestine. 1 h after the infusion of 14C-labelled ISDN into the large intestine of sheep filled with normal contents 14C-activity was detected in the plasma, a maximum was reached after 4 h. Renal excretion of ISDN or its 14C-labelled metabolites was parallel to the ISDN concentration in blood. Microbial degradation of ISDN to CO2 in colon contents was insignificant.
mesh_terms: D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D003106:Colon / Q000378:metabolism; D006168:Guinea Pigs; D007082:Ileum / Q000378:metabolism; D066298:In Vitro Techniques; D007408:Intestinal Absorption; D007422:Intestines / Q000382:microbiology; D007548:Isosorbide Dinitrate / Q000378:metabolism*; D007583:Jejunum / Q000378:metabolism; D007700:Kinetics; D008297:Male; D012756:Sheep
chemical_list: D002245:Carbon Dioxide; D007548:Isosorbide Dinitrate
vernacular_title: Resorption von Isosorbiddinitrat im Colon und Dünndarm von Meerschweinchen und im Colon von Schafen.