Gonadotrophin-release upon iv-administration of a long-acting analogue of luteinizing hormone-releasing hormone in male patients with elevated serum estradiol-concentrations due to chronic liver disease.
The response of LH and FSH upon the administration of D-Ser-(TBU)6-EA10-LH-RH, an analogue of luteinizing hormone-releasing hormone (LH-RH) with prolonged action was evaluated in 6 male patients with increased serum-concentrations of estradiol (E2) due to chronic liver disease. When compared to healthy, male controls (n = 7) basal levels of LH and FSH as well as the secretory response of both gonadotrophins upon the administration of the LH-RH-analogue were larger in patients with chronic liver disease although the qualitative pattern of response was identical with that observed in healthy males. It is concluded that elevated serum-concentrations of E2 in patients with chronic liver disease do not induce qualitative changes in the secretory response of gonadotrophins following the administration of D-Ser-(TBU)6-EA-10-LH-RH.
D000328:Adult; D002064:Buserelin; D002908:Chronic Disease; D004958:Estradiol / Q000097:blood*; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007987:Gonadotropin-Releasing Hormone / Q000031:analogs & derivatives*; D006432:Hemochromatosis / Q000097:blood; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D008875:Middle Aged
D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002064:Buserelin