title: Deoxyribonucleic acid methylation in mycobacteria.
abstract: Deoxyribonucleic acid modification in six strains of mycobacteria was investigated. The presence of 5-methylcytosine in the virulent strain Mycobacterium tuberculosis H37Rv and its absence in the avirulent strain M. tuberculosis H37Ra and other saprophytic, fast-growing mycobacteria appear to be the salient features. However, deoxyribonucleic acid from M. smegmatis SN2 lysogenized with the temperature phage I3 showed the presence of 5-methylcytosine. All of the strains had N6-methyladenine.
mesh_terms: D044503:5-Methylcytosine; D000225:Adenine / Q000031:analogs & derivatives* / Q000032:analysis; D001482:Base Composition; D003596:Cytosine / Q000031:analogs & derivatives* / Q000032:analysis; D004269:DNA, Bacterial / Q000032:analysis*; D008745:Methylation; D009161:Mycobacterium / Q000032:analysis*; D009168:Mycobacterium phlei / Q000032:analysis; D009169:Mycobacterium tuberculosis / Q000032:analysis* / Q000472:pathogenicity
chemical_list: D044503:5-Methylcytosine; D000225:Adenine; D003596:Cytosine; D004269:DNA, Bacterial; C000730567:6-methyladenine