Poly (ADP-ribosylation) in N, N-diethylnitrosamine-treated mice.
1. Liver nuclei isolated from male mice treated with the carcinogen N, N-diethylnitrosamine were examined for the homopolymer poly(adenosine diphosphate ribose) and for the activity of the conjugate polymerase. 2. At all levels of the carcinogen tested, a concomitant increase in both poly(adenosine diphosphate ribose) content and activity of the enzyme were found. 3. Both responses were transitory and dose dependent.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D004052:Diethylnitrosamine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009602:Nitrosamines / Q000494:pharmacology*; D009702:Nucleoside Diphosphate Sugars / Q000378:metabolism*; D011064:Poly Adenosine Diphosphate Ribose / Q000378:metabolism*; D011065:Poly(ADP-ribose) Polymerases / Q000378:metabolism
D009602:Nitrosamines; D009702:Nucleoside Diphosphate Sugars; D011064:Poly Adenosine Diphosphate Ribose; D004052:Diethylnitrosamine; D011065:Poly(ADP-ribose) Polymerases