Clozapine: plasma levels and prolactin response.
Serial plasma clozapine levels and serum prolactin levels were determined in two schizophrenic patients receiving clozapine, a novel antipsychotic drug. Despite marked therapeutic response and substantial clozapine blood levels, prolactin levels obtained 11--12 h after the last oral dose were unaffected or only minimally elevated. This confirms previous evidence of clozapine's unusual characteristics.
D000328:Adult; D003024:Clozapine / Q000097:blood* / Q000494:pharmacology; D003984:Dibenzazepines / Q000097:blood*; D006801:Humans; D008297:Male; D011388:Prolactin / Q000097:blood*; D011954:Receptors, Dopamine / Q000187:drug effects; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy
D003984:Dibenzazepines; D011954:Receptors, Dopamine; D011388:Prolactin; D003024:Clozapine