Altered burst responses in hippocampal CA3 neurons injected with EGTA.
Intracellular injection of EGTA abolished the hyperpolarization seen after spontaneous and evoked bursts of action potentials in hippocampal CA3 neurons. Simultaneously recorded, orthodromically elicited IPSPs were relatively unaffected by this treatment. It is concluded that CA3 neurons generate at least two types of hyperpolarization: one resulting from a calcium-mediated potassium conductance and the other from increased conductance to chloride.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D004533:Egtazic Acid / Q000494:pharmacology*; D005026:Ethylene Glycols / Q000494:pharmacology*; D005071:Evoked Potentials / Q000187:drug effects; D006168:Guinea Pigs; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D007700:Kinetics; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D011188:Potassium / Q000378:metabolism
D005026:Ethylene Glycols; D004533:Egtazic Acid; D011188:Potassium; D002118:Calcium