The increase of a normally occurring K cell population during progressive tumor growth in mice.
K cell activity of the spleen cells from normal and tumor-bearing mice was compared using an antibody-dependent cellular cytotoxicity assay. The K cell activity increased with progressive tumor growth (syngeneic) compared to the K cell activity of normal mice. The increase in K cell activity most likely reflected an increase in the numbers of K cells normally present in nontumor-bearing mice rather than the emergence of a distinct population of K cells induced by the growing tumor.
D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D000936:Antigen-Antibody Complex; D002454:Cell Differentiation; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D002645:Chickens; D005260:Female; D005354:Fibrosarcoma / Q000276:immunology* / Q000473:pathology; D007694:Killer Cells, Natural / Q000166:cytology* / Q000276:immunology / Q000473:pathology; D008297:Male; D012515:Mast-Cell Sarcoma / Q000276:immunology; D051379:Mice; D008811:Mice, Inbred DBA; D011817:Rabbits; D011961:Receptors, Fc; D012397:Rosette Formation
D000936:Antigen-Antibody Complex; D011961:Receptors, Fc