Changes in colloid osmotic pressure with plasma albumin concentration associated with extracorporeal circulation.
Colloid pressure (COP), plasma albumin concentration, haematocrit, and blood-gas tensions were measured in 16 patients undergoing open-heart surgery with cardiopulmonary bypass. The use of crystalloid priming and cardioplegia solutions resulted in a 60% decrease in COP, a 48% decrease in plasma albumin concentration and a 35% decrease in haematocrit. These measurements had returned to pre-perfusion values 6 h after the end of surgery. The alveolar-arterial PO2 difference increased significantly after by-pass and returned to pre-perfusion values within the same time scale. Right-to-left shunt increased from 7.9 to 10.3% 30 min after the end of by-pass. It is concluded that, in the absence of an increase in left atrial pressure, marked decreases in COP can be tolerated without the occurrence of pulmonary oedema.
D000328:Adult; D002245:Carbon Dioxide / Q000097:blood; D002315:Cardiopulmonary Bypass; D003102:Colloids; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009997:Osmotic Pressure; D010100:Oxygen / Q000097:blood; D010313:Partial Pressure; D012709:Serum Albumin / Q000378:metabolism*
D003102:Colloids; D006454:Hemoglobins; D012709:Serum Albumin; D002245:Carbon Dioxide; D010100:Oxygen