Non-toxic inhibition of extracellular tumor enzymes--potential in cancer therapy.
Enzymes characteristically found in the extracellular fluid of tumors, or in elevated concentration in the plasma of tumor-bearing hosts--such as certain glycosidases, certain proteases, and tyrosinase--may possibly play a role in maintaining malignant transformation, promoting tumor invasion, or preventing immune rejection. Experimental data suggests that inhibition of these enzymes could have clinical value. A possible role for such inhibition in a generalized "reverse transformation" strategy is proposed.
D000818:Animals; D004791:Enzyme Inhibitors / Q000627:therapeutic use*; D005110:Extracellular Space / Q000201:enzymology*; D005959:Glucosidases / Q000037:antagonists & inhibitors; D006801:Humans; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology*; D010447:Peptide Hydrolases / Q000378:metabolism; D011480:Protease Inhibitors / Q000627:therapeutic use
D004791:Enzyme Inhibitors; D011480:Protease Inhibitors; D014442:Monophenol Monooxygenase; D005959:Glucosidases; D010447:Peptide Hydrolases