The effect of phenobarbital and 3'-methyl-N,N-dimethyl-4-aminoazobenzene administration on catalytic, binding and immunological properties of ligandin subunits in rat liver.
Following administration of phenobarbital to rats, liver ligandin content, bilirubin binding, glutathione-S-transferase and steroid isomerase activities increased by 150% and the 22000-dalton subunit was selectively increased. Following administration of 3'-methyl-N,N-dimethyl-4-aminoazobenzene, rat liver ligandin content and steroid isomerase decreased by 65%, glutathione-S-transferase increased by 100%, bilirubin binding was abolished, and the relative proportion of the 22000- and 25000-dalton subunits remained unchanged.
D000818:Animals; D001663:Bilirubin / Q000378:metabolism; D002942:Circular Dichroism; D003600:Cytosol / Q000201:enzymology; D004591:Electrophoresis, Polyacrylamide Gel; D005982:Glutathione Transferase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology*; D008297:Male; D008749:Methyldimethylaminoazobenzene / Q000494:pharmacology*; D008970:Molecular Weight; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D013251:Steroid Isomerases / Q000378:metabolism; D004124:p-Dimethylaminoazobenzene / Q000031:analogs & derivatives*
D008749:Methyldimethylaminoazobenzene; D004124:p-Dimethylaminoazobenzene; D005982:Glutathione Transferase; D013251:Steroid Isomerases; D001663:Bilirubin; D010634:Phenobarbital