title: Suppression of early rhesus sensitization by passive anti-D immunoglobulin: suppression of early rhesus sensitization.
abstract: Anti-D immunoglobulin is an effective prophylactic against rhesus isoimmunization. It is generally regarded as ineffective once antibody production has developed though there have been a number of inconclusive reports suggesting it may suppress early sensitization. Anti-D (100 micrograms) was given after delivery of a rhesus (D) positive child to a rhesus (D) negative mother who was shown to have anti-D antibodies at that time by five tests on two separate specimens in two different laboratories and by a weakly positive direct anti-globulin test on the cord blood. In a further pregnancy with a rhesus (D) positive child no antibody was detected by multiple tests including enzyme technique.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007116:Immunization, Passive; D007165:Immunosuppression Therapy; D007518:Isoantibodies / Q000276:immunology*; D011247:Pregnancy; D012204:Rh-Hr Blood-Group System / Q000276:immunology*; D013997:Time Factors
chemical_list: D007518:Isoantibodies; D012204:Rh-Hr Blood-Group System