The effect of calcium dobesilate on albumin leakage of the conjunctival vessels.
Calcium dobesilate significantly reduced the leakage of serum albumin in the tear fluid in patients with chronic inflammatory reactions of the conjunctiva. In the majority of cases reduction of serum albumin concentration in the tear-fluid was treatment related. The marked increase in tear albumin concentration after treatment, found in two cases, was caused by a sharp increase in the inflammatory reaction due to an exacerbation of the underlying disease during the trial period. No relation was found between improvement of symptoms as reported by the patients and alterations in serum albumin concentrations.
D001557:Benzenesulfonates / Q000627:therapeutic use*; D002123:Calcium Dobesilate / Q000494:pharmacology / Q000627:therapeutic use*; D002199:Capillary Permeability / Q000187:drug effects; D003228:Conjunctiva / Q000098:blood supply; D003231:Conjunctivitis / Q000188:drug therapy; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D005779:Immunodiffusion; D007637:Keratoconjunctivitis / Q000188:drug therapy*; D012709:Serum Albumin / Q000032:analysis; D013666:Tears / Q000032:analysis / Q000187:drug effects*
D001557:Benzenesulfonates; D012709:Serum Albumin; D002123:Calcium Dobesilate