[Chemotherapy of tuberculosis and the immunomechanisms of the macroorganism. I. Inhibition of migration of leucocytes and the concentration of serum-immunoglobulin A in the phase of prime therapy of tuberculosis of the respiratory system (author's transl)].
The inhibition of migration of leucocytes (stimulated by PPD) and the concentration of serum-immunoglobulin A had been controlled in 50 patients with bacteriologically verified tuberculosis of the respiratory system. All patients showed a clear hypersensitivity of delayed type with inhibition of migration of leucocytes and high concentrations of serum IgA before the therapy run. In patients with effective therapy there resulted a decline of hypersensitivity of delayed type and of the concentration of IgA. All patients, who still had mycobacterium tuberculosae in the sputa in spite of a correct therapy for 3 months no changes of controlled parameters could be recognized. These results will be interpreted that the effect of an antimycobacterial therapy is accompanied by a clear decline of hypersensitivity of delayed type and parallel decline of protective immunity at least of humoral character, likely not very favourable for the patients.
D000995:Antitubercular Agents / Q000627:therapeutic use; D002464:Cell Migration Inhibition; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000188:drug therapy; D007070:Immunoglobulin A / Q000032:analysis*; D007962:Leukocytes / Q000276:immunology; D009169:Mycobacterium tuberculosis / Q000302:isolation & purification; D013183:Sputum / Q000382:microbiology; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000276:immunology
D000995:Antitubercular Agents; D007070:Immunoglobulin A
Chemotherapie der Tuberkulose und die Immunmechanismen des Makroorganismus. I. Hemmung der Leukozytenwanderung und Konzentration des Serum-Immunglobulins A im Verlauf der Intensivphase der Erstbehandlung der Tuberkulose des Atmungssystems.