title: A new combination of drugs intended to be used as a preventive measure for the postextraction complications. A preliminary report.
abstract: Fifteen extraction sockets packed with a new drug combination, including a local anesthetic (cincain chloride), a local antiseptic (tri-iodomethane) and two drugs with a potent antifibrinolytic activity (tranexamic acid and propyl-hydroxybenzoic acid) in Gelfoam as a vehicle, were assessed clinically with special reference to the development of the postextraction symptoms, dry socket included. As a control series, 15 extraction sockets allowed to undergo a spontaneous healing were similarly evaluated. All the sockets in both series were found to heal according to the normal sequence. There were, however, statistically highly significant differences between the two series with regard to the clotting time, postextraction pain and the need for adjunct analgesics, in favor of the sockets packed with the compound in test. The observed beneficial effects of the test compound are discussed in the light of the recently elucidated etiologic and pathogenetic mechanisms leading to the development of dry socket, and a conclusion is drawn that the present results, although preliminary due to the limited number of patients, advocate further evaluation of the new drug combination and its applicability in the prevention of the troublesome postextraction complications, including dry socket.
mesh_terms: D000293:Adolescent; D000328:Adult; D003509:Cyclohexanecarboxylic Acids / Q000627:therapeutic use*; D003992:Dibucaine / Q000627:therapeutic use*; D004338:Drug Combinations; D004368:Dry Socket / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D006847:Hydrocarbons, Iodinated / Q000627:therapeutic use*; D008875:Middle Aged; D010226:Parabens / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control; D014081:Tooth Extraction / Q000009:adverse effects*; D014148:Tranexamic Acid / Q000627:therapeutic use*; D014945:Wound Healing
chemical_list: D003509:Cyclohexanecarboxylic Acids; D004338:Drug Combinations; D006847:Hydrocarbons, Iodinated; D010226:Parabens; D014148:Tranexamic Acid; C010473:iodoform; D003992:Dibucaine; C006068:propylparaben