The anticonvulsant effect of phencyclidine in rats.
Phencyclidine hydrochloride (PCP), injected subcutaneously into rats 30 min before exposure to the chemical convulsant flurothyl, raised seizure thresholds in a dose-related manner. The narcotic antagonist naloxone was ineffective in blocking the PCP-induced effect. This anti-convulsant property of PCP is like that previously reported for the narcotic agonist-antagonists cyclazocine and SKF 10,047 (N-allylnormetazocine), which also resemble PCP in their ability to induce psychotomimetic behavior. The data support the idea that these three drugs act on the same receptors.
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats
D000927:Anticonvulsants; D009270:Naloxone; D010622:Phencyclidine