Effects of thyrotropin-releasing hormone and metoclopramide in patients with phenothiazine-induced hyperprolactinemia.
TRH and metoclopramide tests were performed in 10 female patients with presumed phenothiazine-induced hyperprolactinemia to define the serum PRL response to these agents. Our results show that the serum PRL response to metoclopramide is blunted in most patients with phenothiazine-induced hyperprolactinemia, and the serum PRL response to TRH is exaggerated in most patients during and 3 weeks after stopping phenothiazines.
D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008787:Metoclopramide; D010640:Phenothiazines / Q000009:adverse effects*; D010911:Pituitary Neoplasms / Q000097:blood / Q000175:diagnosis; D011388:Prolactin / Q000097:blood*; D013973:Thyrotropin-Releasing Hormone
D010640:Phenothiazines; D013973:Thyrotropin-Releasing Hormone; D011388:Prolactin; D008787:Metoclopramide