title: Sensitivity of gonococci to rosoxacin compared with that of penicillin, cefuroxime and tetracycline.
abstract: The in vitro activity of rosoxacin, a pyridyl quinolone derivative against Neisseria gonorrhoeae is compared with that of penicillin, cefuroxime and tetracycline. Three groups of gonococci comprising of beta-lactamase-positive and negative strains and gonococci with high penicillin MICs are studied. Rosoxacin was the most active against the entire spectrum of gonococci tested in vitro and its activity is not affected by the production of beta-lactamase by some gonococci.
mesh_terms: D042462:4-Quinolones; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D002444:Cefuroxime / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009344:Neisseria gonorrhoeae / Q000187:drug effects* / Q000201:enzymology; D010400:Penicillin G / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology*; D015363:Quinolones; D013752:Tetracycline / Q000494:pharmacology; D001618:beta-Lactamases / Q000378:metabolism
chemical_list: D042462:4-Quinolones; D000900:Anti-Bacterial Agents; D011804:Quinolines; D015363:Quinolones; C021083:rosoxacin; D001618:beta-Lactamases; D013752:Tetracycline; D002444:Cefuroxime; D010400:Penicillin G