The accumulation of 2-deoxyglucose-6-phosphate activates glycogen synthase (and inactivates glycogen phosphorylase) in rat skeletal muscle.
In the muscle loaded with 2-dGlc "in vitro" (this sugar is accumulated as hexosephosphate) glycogen synthase I levels are changed by a mechanism which is additive to those of hormones such as insulinor epinephrine. The levels of glycogen phosphorylase are decreased only at the highest 2-dGlc-6-P concentration. The role of this effect of sugar phosphate - which has been attributed to the activation of muscle phosphatase (6) - is discussed with regard to glycogen metabolism during muscle function.
D000818:Animals; D004789:Enzyme Activation; D019298:Glucose-6-Phosphate / Q000031:analogs & derivatives*; D005958:Glucosephosphates / Q000378:metabolism*; D006006:Glycogen Synthase / Q000378:metabolism*; D009132:Muscles / Q000201:enzymology*; D006005:Phosphorylases / Q000037:antagonists & inhibitors*; D051381:Rats; D011919:Rats, Inbred Strains
D005958:Glucosephosphates; C015785:2-deoxyglucose-6-phosphate; D019298:Glucose-6-Phosphate; D006005:Phosphorylases; D006006:Glycogen Synthase