Delivery of the topical antimicrobial agents silver sulfadiazine, gentamicin and nystatin to infected burn wounds in rats from preloaded synthetic dressings.
1. A synthetic burn dressing made from polyethylene glycol - 400 (PEG) and poly-2-hydroxyethyl methacrylate (PHEMA) can be prepared to contain topical antimicrobial agents. 2. Sheets of these antimicrobial loaded dressings may be applied to the wounds or alternatively, the synthetic dressing incorporating the active drugs may be formed directly on the burn wound from the PEG-PHEMA drug mixture. 3. The antimicrobials (silver sulfadiazine, gentamicin and nystatin) are continuously and effectively released from the solid dressing over 2-11 days.
D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D001458:Bandages; D002056:Burns / Q000188:drug therapy*; D002176:Candida albicans / Q000187:drug effects; D003692:Delayed-Action Preparations; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use; D009761:Nystatin / Q000008:administration & dosage / Q000627:therapeutic use; D011092:Polyethylene Glycols; D011102:Polyhydroxyethyl Methacrylate; D011109:Polymethacrylic Acids; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D051381:Rats; D013411:Sulfadiazine / Q000008:administration & dosage / Q000627:therapeutic use; D014946:Wound Infection / Q000188:drug therapy*
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D003692:Delayed-Action Preparations; D005839:Gentamicins; D011109:Polymethacrylic Acids; D013411:Sulfadiazine; D009761:Nystatin; D011102:Polyhydroxyethyl Methacrylate; D011092:Polyethylene Glycols