Characterization of an amyloid fibril protein from localized amyloidosis of the skin as lambda immunoglobulin light chains of variable subgroup I (A lambda I).
Amyloid fibrils obtained from a case (Hud) of localized, tumorous amyloidosis of the skin were investigated by immunological and biochemical methods including amino acid sequence studies. Evidence was obtained that a lambda immunoglobulin light chain protein, A lambda I, and differently sized N terminal fragments (mol. wt 14,000 and 10,000) of the same protein comprised a major component of the fibrils. The chemical nature of this protein suggested that this case of cutaneous amyloidosis belonged to the idiopathic form of amyloidosis, probably as a special type of systemic, idiopathic amyloid disease.
D000595:Amino Acid Sequence; D000682:Amyloid / Q000032:analysis / Q000276:immunology; D000686:Amyloidosis / Q000276:immunology*; D000941:Antigens / Q000032:analysis; D002850:Chromatography, Gel; D005260:Female; D006801:Humans; D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains; D008875:Middle Aged; D012871:Skin Diseases / Q000276:immunology*
D000682:Amyloid; D000941:Antigens; D007147:Immunoglobulin Light Chains; D007146:Immunoglobulin lambda-Chains