Estrogens induce lipoxygenase derivative formation in rabbit lens.
The effect of estrogens on arachidonic acid metabolism was studied in lenses from normal and sex hormone-treated female rabbits. Analysis of the metabolites derived from incubation of these lenses with (1-14C) arachidonic acid provides the first evidence that estradiol activates the lipoxygenase pathway, as indicated by 5-S-hydroxy-6,8,11,14-eicosatetraenoic acid--like product formation, an effect that can be prevented by progestin treatment. Prostaglandin synthesis was not demonstrated by the control or estrogen-treated rabbit lenses, suggesting that lipoxygenase is the major arachidonic acid pathway in the lens.
D015117:5,8,11,14-Eicosatetraynoic Acid / Q000494:pharmacology; D000818:Animals; D016718:Arachidonic Acid; D001095:Arachidonic Acids / Q000096:biosynthesis / Q000378:metabolism*; D002396:Catechols / Q000494:pharmacology; D016861:Cyclooxygenase Inhibitors; D004790:Enzyme Induction / Q000187:drug effects; D004967:Estrogens / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology; D006893:Hydroxyeicosatetraenoic Acids; D007213:Indomethacin / Q000494:pharmacology; D007908:Lens, Crystalline / Q000201:enzymology*; D008084:Lipoxygenase / Q000096:biosynthesis*; D016859:Lipoxygenase Inhibitors; D009637:Masoprocol; D009640:Norethindrone / Q000494:pharmacology; D011817:Rabbits
D001095:Arachidonic Acids; D002396:Catechols; D016861:Cyclooxygenase Inhibitors; D004967:Estrogens; D006893:Hydroxyeicosatetraenoic Acids; D016859:Lipoxygenase Inhibitors; D015117:5,8,11,14-Eicosatetraynoic Acid; D016718:Arachidonic Acid; D004997:Ethinyl Estradiol; C022022:5-hydroxy-6,8,11,14-eicosatetraenoic acid; D009637:Masoprocol; D008084:Lipoxygenase; D009640:Norethindrone; D007213:Indomethacin