Essential fatty acid deficiency during total parenteral nutrition.
Essential fatty acid (EFA) deficiency has become a clinical problem since the advent of fat-free total parenteral nutrition (TPN). The following study was done to determine the minimum fat requirements for patients receiving continuous TPN solution. Seventy-seven patients who had 97 courses of TPN of at least 14 days duration were prospectively studied. The following fat supplementation was given: a) none, b) 10% soybean oil emulsion intravenously at fixed dosage, c) fat from an oral diet, or d) intravenous and oral fat. No patient was EFA deficient before the onset of TPN. EFA deficiency was prevented when at least 3.2% of total calories were given as intravenous fat or at least 15% as oral fat. Lesser amounts of fat decreased the rate of EFA deficiency development but did not prevent it from occurring. The 7.7 g/day of linoleic acid provided in 1000 ml per week of 10% soybean oil emulsion provides adequate fat to prevent EFA deficiency.
D015126:8,11,14-Eicosatrienoic Acid / Q000097:blood / Q000031:analogs & derivatives; D000293:Adolescent; D000328:Adult; D000368:Aged; D001095:Arachidonic Acids / Q000097:blood; D002648:Child; D004041:Dietary Fats / Q000008:administration & dosage; D002149:Energy Intake; D005217:Fat Emulsions, Intravenous / Q000627:therapeutic use; D005228:Fatty Acids, Essential / Q000172:deficiency*; D006801:Humans; D008875:Middle Aged; D009751:Nutritional Requirements; D010288:Parenteral Nutrition / Q000009:adverse effects*; D010289:Parenteral Nutrition, Total / Q000009:adverse effects* / Q000379:methods; D011446:Prospective Studies
D001095:Arachidonic Acids; D004041:Dietary Fats; D005217:Fat Emulsions, Intravenous; D005228:Fatty Acids, Essential; D015126:8,11,14-Eicosatrienoic Acid; C010944:mead acid