Skin lesions in Waldenström's macroglobulinaemia. Characterization of the cellular infiltrate.
A patient with Waldenström's macroglobulinaemia presenting with numerous red or brownish-red, round, papulous lesions of the skin is reported. Skin biopsy revealed a massive infiltrate of immature lymphatic cells of the dermis down to the subcutaneous fat. Approximately 80% of these cells were positive for intracellular IgM and kappa light chains as shown by the immunoperoxidase method. This finding established the skin lesions as part of Waldenström's macroglobulinaemia.
D000368:Aged; D006801:Humans; D007074:Immunoglobulin G / Q000302:isolation & purification; D007075:Immunoglobulin M / Q000302:isolation & purification; D007145:Immunoglobulin kappa-Chains / Q000302:isolation & purification; D007146:Immunoglobulin lambda-Chains / Q000302:isolation & purification; D008297:Male; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000209:etiology* / Q000276:immunology / Q000473:pathology; D008258:Waldenstrom Macroglobulinemia / Q000150:complications*
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D007146:Immunoglobulin lambda-Chains