Synergistic effects of hypoglycaemic sulphonylureas and antibiotic ionophores upon calcium translocation.
1 Hypoglycaemic sulphonylureas, such as tolbutamide and gliclazide, provoke the translocation of calcium from an aqueous medium into or across a hydrophobic region. The combined effect of sulphonylureas and antibiotic ionophores upon such a process was investigated. 2 The magnitude of the sulphonylurea-induced translocation of calcium was more marked in the presence than in the absence of A23187. Gliclazide and tolbutamide also enhanced, although less markedly, X537A-mediated calcium translocation. The effect of the sulphonylureas was even less marked in the presence of both ionophores, which acted synergistically in causing calcium translocation. 3 A non-hypoglycaemic sulphonylurea and diazoxide failed to affect ionophore-mediated calcium translocation. Gliclazide failed to enhance X537A-mediated sodium translocation. 4 It is proposed that the primary site of action of hypoglycaemic sulphonylureas upon calcium-dependent physiological processes may correspond to a drug-induced facilitation of calcium transport across the plasma membrane, as mediated by native ionophores.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000001:Calcimycin; D002118:Calcium / Q000378:metabolism*; D002132:Calcium Radioisotopes; D055598:Chemical Phenomena; D002621:Chemistry; D004357:Drug Synergism; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D007476:Ionophores / Q000494:pharmacology*; D007832:Lasalocid; D013453:Sulfonylurea Compounds / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D002132:Calcium Radioisotopes; D007004:Hypoglycemic Agents; D007476:Ionophores; D013453:Sulfonylurea Compounds; D000001:Calcimycin; D002118:Calcium; D007832:Lasalocid