Intracerebral 6-hydroxydopamine produces extensive damage to the blood-brain barrier in rats.
Extensive extravasation of intravenously administered horseradish peroxidase (HRP) was observed in rat brains infused intranigrally with 8 microgram/4 microliter or 4 microgram/2 microliter 6-hydroxydopamine (6-OHDA), suggesting that the cytotoxin produced widespread alterations in the integrity of the blood-brain barrier. Such damage was dose-dependent and occurred in the mesencephalon around the cannula tip, along the cannula tract, and in the cerebral cortex. The extent of HRP extravasation diminished as a function of increasing time after 6-OHDA administration. These findings indicate that alterations in blood-brain barrier permeability may contribute to the constellation of dysfunctions and possible recovery of function following intranigral infusions of the cytotoxin.
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006624:Hippocampus / Q000187:drug effects; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D008636:Mesencephalon / Q000187:drug effects; D016627:Oxidopamine; D051381:Rats; D011919:Rats, Inbred Strains; D013378:Substantia Nigra / Q000187:drug effects; D013788:Thalamus / Q000187:drug effects
D006892:Hydroxydopamines; D016627:Oxidopamine