Mutants of Corynebacterium diphtheriae PW8 that produce toxin in medium with excess iron.
Two mutants that produce toxin in medium with excess iron were isolated from the PW8 strain of Corynebacterium diphtheriae. These mutants produced as much toxin in medium containing excess iron (3 mug of Fe2+ per ml) as did the parent PW8 strain in iron-depleted medium, and they will be very useful for easy production of toxin.
D003353:Corynebacterium diphtheriae / Q000235:genetics / Q000254:growth & development; D003470:Culture Media; D004167:Diphtheria Toxin / Q000096:biosynthesis*; D005290:Ferric Compounds / Q000494:pharmacology*; D007501:Iron / Q000494:pharmacology*; D009154:Mutation
D003470:Culture Media; D004167:Diphtheria Toxin; D005290:Ferric Compounds; D007501:Iron