Renal transport of aromatic acids in patients with phenylketonuria.
Renal clearance of phenylpyruvic acid is maximal at a plasma concentration of 40-60 mumol/l. This concentration is obtained with plasma phenylalanine concentrations of 1.0-1.2 mmol/l, the threshold for separating classical phenylketonuria from phenylketonuria variants.
D002648:Child; D006801:Humans; D007668:Kidney / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D010661:Phenylketonurias / Q000378:metabolism*; D010667:Phenylpyruvic Acids / Q000097:blood / Q000652:urine*
D010667:Phenylpyruvic Acids; C031606:phenylpyruvic acid