[Changes in mitochondrial and microsomal electron transport as affected by o,p'-dichlorodiphenyldichloroethane].
The paper deals with the influence of 1-(o-chlorophenyl)-1-(p-chlorophenyl)-2.2-dichloroethane (o,p'-DDD, chloditane) on NADPH-dependent reduction of cytochrome c, ferricyanide, 2,6-dichlorophenolindophenol and neotetrazolium; 156 and 312 mumol o,p'-DDD was added to the dog adrenal mitochondrial and microsomal suspension. Ferricyanide reduction decreased and neotetrazolium reduction increased under the influence of o,p'-DDD. Reduction of cytochrome c was inhibited in microsomal fraction and activated in mitochondrial one. o,p'-DDD exerted no influence on 2,6-dichlorophenolindophenol reduction in the adrenal subcellular fractions. The possible mechanisms of o,p'-DDD action on the electron transport system were discussed.
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D004285:Dogs; D004579:Electron Transport; D007700:Kinetics; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism*; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism*; D008939:Mitotane / Q000494:pharmacology*; D009251:NADPH-Ferrihemoprotein Reductase / Q000378:metabolism; D010084:Oxidation-Reduction
D008939:Mitotane; D009251:NADPH-Ferrihemoprotein Reductase
Izmenenie élektronnogo transporta v mitokhondriiakh i mikrosomakh kory nadpochechnikov pod vliianiem o,p'-dikhlordifenildikhlorétana.