Monoclonal antibodies to detect human tumours: an experimental approach.
The use of monoclonal antibodies which can be raised to antigens of choice offers a selective and specific approach for the detection of tumours both in vivo and at a cellular level in biopsy specimens. We demonstrate that a monoclonal antibody raised to human teratoma will localise in a teratoma, growing as a xenograft in immune-suppressed mice.
D000818:Animals; D000906:Antibodies / Q000032:analysis*; D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm / Q000032:analysis*; D001345:Autoradiography; D006801:Humans; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology; D011863:Radioimmunoassay; D013724:Teratoma / Q000175:diagnosis* / Q000276:immunology / Q000473:pathology; D014183:Transplantation, Heterologous
D000906:Antibodies; D000911:Antibodies, Monoclonal; D000912:Antibodies, Neoplasm