Bioavailability of some lysine derivatives in mice.
Growth assays using mice on synthetic amino acid diets showed that substituting epsilon-N-methyl-L-lysine, epsilon-N-dimethyl-L-lysine and epsilon-N-trimethyl-L-lysine for lysine resulted in relative replacement values about 1/12, 1/20 and 1/25, respectively, of that obtained with the standard lysine diet. Similar studies showed that the alpha-N-acetyl-L-lysine is not utilized by mice and that the relative the replacement value of epsilon-N-acetyl-L-lysine was about 3% of that of lysine. Analogous substitution of D-lysine and the lysine sulfur-containing analog, S-(2-aminoethyl)-L-cysteine, for lysine resulted in weight losses during the feeding period. The results are discussed with reference to factors that are expected to influence the biological utilization f lysine analogs and derivatives.
D000818:Animals; D001681:Biological Assay; D001682:Biological Availability; D001835:Body Weight; D003545:Cysteine / Q000031:analogs & derivatives / Q000378:metabolism; D004044:Dietary Proteins / Q000378:metabolism*; D008239:Lysine / Q000031:analogs & derivatives* / Q000378:metabolism; D051379:Mice; D013329:Structure-Activity Relationship
D004044:Dietary Proteins; C005205:epsilon-N-methyllysine; C018926:epsilon N-dimethyllysine; C000204:S-2-aminoethyl cysteine; C003712:trimethyllysine; D008239:Lysine; D003545:Cysteine