On some similarity between membrane antigens of the cell of Zajdela hepatoma and liver of rats subjected to a single 4-dimethylaminoazobenzene injection.
Zajdela ascitic hepatoma cells were tested with the organ specific immune serum against kidney cell ghosts in the reaction of immunofluorescence. On the surface of the hepatoma cells occurred heteroorganic antigens characteristic of the membranes of intact rat kidney but never observed in their liver. Similar antigens were found in the liver of rats 1-18 days following a single injection of a hepato-carcinogen--4-dimethylaminoazobenzene but not after 4-diethylaminoazobenzene, which is a noncarcinogenic structural analogue of 4-dimethylaminoazobenzene. Noteworthy is the transient nature of this alteration in antigenic structure, since from day 21 after carcinogen application it was no longer found.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D007668:Kidney / Q000276:immunology; D008099:Liver / Q000187:drug effects / Q000276:immunology*; D008113:Liver Neoplasms / Q000139:chemically induced / Q000276:immunology; D008114:Liver Neoplasms, Experimental / Q000276:immunology*; D008297:Male; D051381:Rats; D004124:p-Dimethylaminoazobenzene
D000951:Antigens, Neoplasm; D000954:Antigens, Surface; D004124:p-Dimethylaminoazobenzene