Concentration of phenoximethylpenicillin, clindamycin and tinidazole in dental cysts.
In the treatment of bacterial infections, adequate antibiotic concentrations must be realised at the site of infection. Levels of 3 antibiotics--phenoximethylpenicillin, clindamycin and tinidazole - were measured in serum and fluid of periapical odontogenic cysts in 30 patients undergoing enucleation of periapical cysts. After a single dose of 500 mg tinidazole, the concentration of tinidazole in the cystic fluid was 4.3 micrograms/ml, which was about 1/3 of the concentration in the serum. No measurable levels were achieved in the cystic fluid with phenoximethylpenicillin or clindamycin.
D000328:Adult; D000368:Aged; D002981:Clindamycin / Q000008:administration & dosage / Q000032:analysis*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009593:Nitroimidazoles / Q000032:analysis*; D010404:Penicillin V / Q000008:administration & dosage / Q000032:analysis*; D011842:Radicular Cyst / Q000032:analysis* / Q000188:drug therapy; D013997:Time Factors; D014011:Tinidazole / Q000008:administration & dosage / Q000032:analysis*
D009593:Nitroimidazoles; D014011:Tinidazole; D002981:Clindamycin; D010404:Penicillin V