Alternating treatment of common bile duct stones with a modified glyceryl-1-monooctanoate preparation and a bile acid-EDTA solution by nasobiliary tube.
Twenty patients with bile duct stones were treated via an indwelling nasobiliary tube with a modified Capmul 8210 preparation (GMOC) and alternating with a bile salt-EDTA (BA-EDTA) solution for an average of 12 days. In vitro the dissolution capacity of GMOC and BA-EDTA for cholesterol stones was higher than that of Capmul 8210. The nasobiliary tube was tolerated well for a maximum of 84 days; this renders us independent of the T-tube. The therapeutic success rate of GMOC was 64%, even though we treated mostly old and large concrements. Side effects occurred markedly less than with Capmul 8210. In patients with acute cholecystitis or cholangitis the clinical course improved under therapy, and there was no deterioration of a chronic condition.
D000368:Aged; D002210:Caprylates; D002793:Cholic Acids / Q000008:administration & dosage*; D003135:Common Bile Duct; D003840:Deoxycholic Acid / Q000031:analogs & derivatives*; D004338:Drug Combinations; D004492:Edetic Acid / Q000008:administration & dosage*; D005260:Female; D042882:Gallstones / Q000188:drug therapy*; D005989:Glycerides / Q000008:administration & dosage*; D006801:Humans; D066298:In Vitro Techniques; D007263:Infusions, Parenteral; D007440:Intubation; D008297:Male; D008875:Middle Aged; D009666:Nose; D012996:Solutions; D012997:Solvents / Q000008:administration & dosage*; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage*
D002210:Caprylates; D002793:Cholic Acids; D004338:Drug Combinations; D005989:Glycerides; D012996:Solutions; D012997:Solvents; D003840:Deoxycholic Acid; D014580:Ursodeoxycholic Acid; D004492:Edetic Acid; C025343:monooctanoin