title: [Prophylaxis of recurrent urinary infections in children. Long-term use of a weak dose of trimethoprim-sulfamethoxazole].
abstract: The efficacy of a long-term prophylaxis with Co-trimoxazole was studied in 18 girls with recurrent urinary tract infections. SEven patients had neither anatomical nor functional anomalies of the urinary tract. Eight patients had a vesico-ureteral reflux, and three patients a complex urinary problem. The following therapeutic plan was applied: administration of a low dose of Co-trimoxazole (TMP: 0,6-1 mg/kg) given as a single evening dose during 3 months followed by a 3-month period without treatment. The children were followed in this way during 2 years. Seven children had no reinfection from the start of the prophylaxis during the 2 years of observation. Nine children had a significant decrease of the number of reinfections during the Co-trimoxazole treatment periods. Two children without anatomical anomaly had early reinfections with Co-trimoxazole resistant germs. No side effects related to Co-trimoxazole have been observed, and the tolerance of treatment was excellent. Co-trimoxazole administered as a single evening low dose efficiently prevented the recurrence of urinary tract infections.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008134:Long-Term Care; D012008:Recurrence; D013411:Sulfadiazine / Q000627:therapeutic use*; D014295:Trimethoprim / Q000627:therapeutic use*; D014552:Urinary Tract Infections / Q000188:drug therapy*; D000096926:Benzenesulfonamides
chemical_list: D004338:Drug Combinations; D013411:Sulfadiazine; D014295:Trimethoprim; C024873:sulfadiazine, trimethoprim drug combination; D000096926:Benzenesulfonamides
vernacular_title: Prophylaxie des infections urinaires récidivantes de l'enfant. Emploi à long terme d'une faible dose de Trimethoprim-Sulfamethoxazole.