Polyamine biosynthesis and skin tumor promotion: inhibition of 12-O-tetradecanoylphorbol-13-acetate-promoted mouse skin tumor formation by the irreversible inhibitor of ornithine decarboxylase alpha-difluoromethylornithine.
D012437:Adenosylmethionine Decarboxylase / Q000378:metabolism; D000818:Animals; D002262:Carboxy-Lyases / Q000037:antagonists & inhibitors*; D004336:Drug Antagonism; D000518:Eflornithine; D007700:Kinetics; D051379:Mice; D009374:Neoplasms, Experimental / Q000201:enzymology; D009952:Ornithine / Q000031:analogs & derivatives* / Q000494:pharmacology; D065108:Ornithine Decarboxylase Inhibitors; D010704:Phorbols / Q000494:pharmacology*; D011073:Polyamines / Q000096:biosynthesis*; D011700:Putrescine / Q000096:biosynthesis; D012867:Skin / Q000187:drug effects / Q000378:metabolism*; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000201:enzymology; D013095:Spermidine / Q000096:biosynthesis; D013096:Spermine / Q000096:biosynthesis; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D065108:Ornithine Decarboxylase Inhibitors; D010704:Phorbols; D011073:Polyamines; D013096:Spermine; D009952:Ornithine; D002262:Carboxy-Lyases; D012437:Adenosylmethionine Decarboxylase; D013755:Tetradecanoylphorbol Acetate; D013095:Spermidine; D011700:Putrescine; D000518:Eflornithine