Comparative toxicity of chemotherapy following partial hepatectomy.
Recent reports document an improved survival in children treated with chemotherapy following hepatic resection for malignant liver tumors. This report compares the effect of commonly employed chemotherapeutic agents on the regenerating liver.
D000818:Animals; D002245:Carbon Dioxide / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D003609:Dactinomycin / Q000009:adverse effects*; D004317:Doxorubicin / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D006498:Hepatectomy / Q000379:methods; D008113:Liver Neoplasms / Q000628:therapy*; D008115:Liver Regeneration / Q000187:drug effects*; D009929:Organ Size; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D014750:Vincristine / Q000009:adverse effects*
D002245:Carbon Dioxide; D003609:Dactinomycin; D014750:Vincristine; D004317:Doxorubicin; D004247:DNA; D013936:Thymidine