Effects of ethyl ester derivatives of valproic acid metabolites on pentylenetetrazol seizures in mice.
The anticonvulsant activity of the ethyl esters of the major valproic acid metabolites was assessed against minimal pentylenetetrazol seizures in adult male ICR mice. The ethyl ester 3-hydroxy-propylpentanoic acid was found to possess significant anticonvulsant activity.
D000818:Animals; D004334:Drug Administration Schedule; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010433:Pentylenetetrazole; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*; D014635:Valproic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
C032264:valproic acid ethyl ester; D014635:Valproic Acid; C032265:3-ketovalproic acid ethyl ester; C032266:3-hydroxypropylpentanoic acid ethyl ester; D010433:Pentylenetetrazole