[Comparative evaluation and analysis of the bradykinin-potentiating properties of D-penicillamine and other thiol and non-thiol kininase inhibitors].
In experiments with an isolated guinea-pig ileum D-penicillamine (3,3-dimethylcysteine) potentiated the spasmogenic effect of bradykinin and exerted no influence on the analogous effects of acetylcholine, histamine and barium chloride. These properties distinguish the drug from other thiol compounds -- unithiol and cysteine. The bradykinin-potentiating action of D-penicillamine excludes the effect on the cholinergic and histaminergic systems, while the bradykinin-potentiating effect of unithiol and cysteine is reversed by atropine and tavegil. 1, 10-Phenanthroline and 8-hydroxyquinoline do not possess the bradykinin-potentiating properties, and, when administered in high doses, reduce the spasmogenic effect of the polypeptide.
D000109:Acetylcholine / Q000008:administration & dosage; D000818:Animals; D001464:Barium / Q000008:administration & dosage; D017609:Barium Compounds; D001920:Bradykinin / Q000008:administration & dosage*; D002712:Chlorides; D003545:Cysteine / Q000008:administration & dosage; D004357:Drug Synergism; D005260:Female; D006168:Guinea Pigs; D006632:Histamine / Q000008:administration & dosage; D066298:In Vitro Techniques; D008297:Male; D015125:Oxyquinoline / Q000008:administration & dosage; D010396:Penicillamine / Q000008:administration & dosage*; D010618:Phenanthrolines / Q000008:administration & dosage; D014494:Unithiol / Q000008:administration & dosage
D017609:Barium Compounds; D002712:Chlorides; D010618:Phenanthrolines; C024986:barium chloride; D001464:Barium; D014494:Unithiol; D015125:Oxyquinoline; D006632:Histamine; D010396:Penicillamine; D003545:Cysteine; D000109:Acetylcholine; D001920:Bradykinin; C025205:1,10-phenanthroline
Sravnitel'naia otsenka i analiz bradikininpotentsiruiushchikh svoĭstv D-penitsillamina i drugikh tiolovykh i netiolovykh ingibitorov kininaz.