title: Variation of antimetabolite sensitivity with different carbon sources in Bacillus subtilis.
abstract: The susceptibility of Bacillus subtilis to amino acid analogues was found to be markedly influenced by the carbon source used in the test media. Thialysine inhibited the bacterium with a greater number of carbon sources than the other two analogues tested. 5-Hydroxylysine was inhibitory with glycerol, lactose, D-xylose, L-arabinose and soluble starch while ethionine showed toxicity with lactose, D-xylose and L-arabinose. None of these analogues were toxic at the levels tested when D-galactose was used as carbon source. The bacterium was not susceptible to thialysine with glycerol, to 5-hydroxylysine with L-arabinose and to ethionine with lactose.
mesh_terms: D001089:Arabinose / Q000378:metabolism; D001412:Bacillus subtilis / Q000187:drug effects* / Q000378:metabolism; D050260:Carbohydrate Metabolism; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D005001:Ethionine / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D005990:Glycerol / Q000378:metabolism; D006901:Hydroxylysine / Q000494:pharmacology*; D008320:Maltose / Q000378:metabolism; D008353:Mannitol / Q000378:metabolism
chemical_list: C000204:S-2-aminoethyl cysteine; D006901:Hydroxylysine; D008353:Mannitol; D008320:Maltose; D001089:Arabinose; D005947:Glucose; D003545:Cysteine; D005990:Glycerol; D005001:Ethionine