[Experimental assessment of some pharmacodynamic features of ketoprofen lysine. Pain relief activity, antipyretic effects, anti-inflammatory activity, anti-platelet aggregation activity and interference with the biosynthesis of prostaglandins].
An experimental assessment was made of the analgesic, anti-inflammatory and platelet anticlumping activity of ketoprophene lysine, and its effect on body temperature and prostaglandin synthesis. The drug's pharmacodynamics was very similar to that of ketoprophene and its gastric tolerance was better. It was also well tolerated by the dog joint surfaces and cardiovascular apparatus when given i.m. or i.v., even at doses higher than those advised for man, or when infiltrated in ketoreceptor areas.
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001831:Body Temperature / Q000187:drug effects; D004285:Dogs; D005260:Female; D007660:Ketoprofen / Q000031:analogs & derivatives / Q000494:pharmacology*; D008239:Lysine / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D010666:Phenylpropionates / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D011453:Prostaglandins / Q000096:biosynthesis*; D011817:Rabbits; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010666:Phenylpropionates; D011453:Prostaglandins; D008315:Malondialdehyde; C029946:ketoprofen lysine; D007660:Ketoprofen; D008239:Lysine
Analisi sperimentale di alcuni aspetti farmacodinamici del ketoprofene lisina. Attività antidolorifica, effetti antipiretici, attività anti-infiammatoria, attività antiaggregante piastrinica ed interferenze con la biosintesi delle prostaglandine.