title: Prediction of the stability of meclofenoxate injection in parenteral admixtures.
abstract: A new method for predicting pharmaceutical stability in parenteral admixtures was studied using meclofenoxate hydrochloride injection as a model preparation. The pH and temperature of clinical parenteral admixtures are not constant, unlike experimental buffer solutions, and it is impossible to predict the accurate degradation ratio by the preceding method described by many authors. This study provides a solution to this problem making possible the accurate prediction of degradation ratios of pharmaceuticals even in such complicated systems.
mesh_terms: D004355:Drug Stability; D006016:Glycolates / Q000008:administration & dosage*; D006863:Hydrogen-Ion Concentration; D007267:Injections; D007700:Kinetics; D002504:Meclofenoxate / Q000008:administration & dosage*; D012996:Solutions; D013696:Temperature
chemical_list: D006016:Glycolates; D012996:Solutions; D002504:Meclofenoxate