Biochemical studies of bone from diabetic rats and rats bearing transplanted pancreatic islets.
A comparison of lysozymal enzymes involved in glycosaminoglycan metabolism in cortical bone found significantly increased activity in the presence of streptozotocin-induced diabetes. The presence of transplanted pancreatic islets and restitution of the normal systemic insulin and glucose values did not alter these changes. The enzyme activity of cancellous bone appeared to be even less responsive to diabetic pathology with changes developing only with advancing age.
D000375:Aging; D000818:Animals; D001842:Bone and Bones / Q000201:enzymology*; D003921:Diabetes Mellitus, Experimental / Q000201:enzymology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005966:Glucuronidase / Q000378:metabolism; D006025:Glycosaminoglycans / Q000378:metabolism*; D006596:Hexosaminidases / Q000378:metabolism; D016381:Islets of Langerhans Transplantation; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D014184:Transplantation, Homologous; D014533:Uridine Diphosphate Glucose Dehydrogenase / Q000378:metabolism; D001616:beta-Galactosidase / Q000378:metabolism; D048828:beta-N-Acetyl-Galactosaminidase
D006025:Glycosaminoglycans; D014533:Uridine Diphosphate Glucose Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D006596:Hexosaminidases; D001616:beta-Galactosidase; D005966:Glucuronidase; D048828:beta-N-Acetyl-Galactosaminidase