[Chlorpromazine effect on plasma concentration of corticosterone, gonadotropins and prolactin in the pregnant rat (author's transl)].
Plasma corticosterone, gonadotropins and prolactin are measured from day 1 (G1) to day 4 (G4) of gestation in normal or chlorpromazine injected rats. Chlorpromazine induces a modification of plasma corticosterone, gonadotropins and prolactin (increase in corticosterone and prolactin at G1, p less than 0,001 or P less than 0,01; decrease in LH at G2, p less than 0,01; no modification of FSH). Differed implantations by chlorpromazine seems to be due to an increase in plasma corticosterone and prolactin at G1 and a decrease in plasma LH at G2.
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D011388:Prolactin / Q000097:blood*; D051381:Rats
D006062:Gonadotropins; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D002746:Chlorpromazine; D003345:Corticosterone
Action de la chlorpromazine sur la concentration plasmatique en corticostérone, en gonadotrophines et en prolactine de la ratte gestante.