title: [Penicillin formation by biochemical mutants of Penicillium chrysogenum and their spontaneous revertants].
abstract: The capacity for the antibiotic production in the auxotrophs of Penicillium chrysogenum with various deficiency and their revertants was studied. It was found that the capacity for penicillin synthesis was impaired to various degrees in the majority of the auxotrophs. Variants with the penicillin production levels by 13--20 per cent higher than those in the initial prototrophic strain were isolated for the first time in selection of the eukaryotes with the method of obtaining highly active revertants from auxotrophs according to the scheme "prototroph-auxotroph-prototroph".
mesh_terms: D001737:Biuret / Q000031:analogs & derivatives / Q000494:pharmacology; D009154:Mutation; D009602:Nitrosamines / Q000494:pharmacology; D010406:Penicillins / Q000096:biosynthesis*; D010407:Penicillium / Q000378:metabolism*; D010408:Penicillium chrysogenum / Q000187:drug effects / Q000378:metabolism* / Q000528:radiation effects; D014466:Ultraviolet Rays
chemical_list: D009602:Nitrosamines; D010406:Penicillins; C008654:N-nitroso-N-methylbiuret; D001737:Biuret
vernacular_title: Obazovanie penitsillina biokhimicheskimi mutantami Penicillium chrysogenum i ikh spontannymi revertantami.