Variations in the intensity of BCG-potentiated alloimmune anti-tumor responses: the differential stimulation of T-cell subpopulations.
The interexperimental variation often observed following the repeated monitoring of immune phenomenon was analysed using the alloimmune cellular response that developed in the spleens of B6AF mice following a challenge with Mastocytoma P815-X2 and intervention with BCG. The response, mediated solely by T cells, could be defined in terms of the involvement of nylon-wool adherent and nonadherent T cells. The relative contribution of each cell type to the response was found to vary considerably and could be use to define the interexperimental variation. Hence when a given treatment resulted in a poor response, the major contributors were nonadherent to nylon-wool, while when the same treatment yielded a good response, adherent cells became the predominant contributors. It was concluded that the inter-experiment variations observed here were a biological event, rather than an experimental artefact, being a function of the relative contribution of different T-cell subpopulations.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D001500:BCG Vaccine / Q000494:pharmacology* / Q000627:therapeutic use; D002448:Cell Adhesion; D003602:Cytotoxicity, Immunologic; D005260:Female; D007111:Immunity, Cellular; D007519:Isoantigens / Q000276:immunology; D012515:Mast-Cell Sarcoma / Q000276:immunology* / Q000628:therapy; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D013601:T-Lymphocytes / Q000145:classification / Q000276:immunology
D000276:Adjuvants, Immunologic; D001500:BCG Vaccine; D007519:Isoantigens