[Cleavage of the side chain of sitosterol by R, S and M mycobacteria variants].
The purpose of this work was to study the capability of the R, S and M variants of 12 strains belonging to 5 mycobacterial species to decompose sitosterol and to transform it, in the presence of 8-hydroxyquinoline, yielding pregnenecarboxylic acid, androst-1,4-diene-3,17-dione, androst-4-ene-3,17-dione and sitostenone. All of the cultures decompose sitosterol, the cells of the M variant being most active and the cells of the R variant having the lowest activity. Differences in the products of transformation were observed not only among species, but also, to a strong degree, among variants of one and the same mycobacterial species.
D001711:Biotransformation; D014644:Genetic Variation; D009161:Mycobacterium / Q000378:metabolism*; D015125:Oxyquinoline / Q000378:metabolism; D012855:Sitosterols / Q000378:metabolism*; D013997:Time Factors
D012855:Sitosterols; D015125:Oxyquinoline
Otshcheplenie bokovoĭ tsepi sitosterina R-, S- i M-variantami mikobakteriĭ.