Serial measurement of circulating immune complexes in healthy subjects.
Circulating immune complex (CIC) levels were serially studied in healthy subjects and in normal rats. In human 3 methods (Clq solubility, complement consumption, and granulocyte phagocytosis tests) were used for the measurement of CIC; in rats, CIC levels were determined by the modified complement consumption test. A marked fluctuation in the CIC level was observed both in healthy human subjects and in normal rats. No correlation between results of the 3 assays used for CIC detection was found indicating that not only the level but the composition of CIC changes continuously in health.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000032:analysis*; D003166:Complement Activating Enzymes / Q000378:metabolism; D015922:Complement C1q; D003165:Complement System Proteins / Q000378:metabolism; D004492:Edetic Acid / Q000494:pharmacology; D006801:Humans; D010587:Phagocytosis; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains
D000936:Antigen-Antibody Complex; D011092:Polyethylene Glycols; D015922:Complement C1q; D003165:Complement System Proteins; D004492:Edetic Acid; D003166:Complement Activating Enzymes