title: [Serological heterogeneity of the immune response to the administration of a multicomponent meningococcal vaccine].
abstract: The characteristic feature of meningococcal polycomponent vaccine is the serological heterogeneity of immune response to the injection of this vaccine, which is due to the fact that the vaccine contains antigens to antibodies detected in meningococcal antisera of all known serogroups: A, B, C, D, X, Y, Z, 29-E and W-135. The hyperimmunization of rabbits with meningococcal polycomponent vaccine results in the formation of antibodies to more than 20 different meningococcal cell-wall antigens occurring in different combinations in 23 strains isolated from patients and in museum strains of every known meningococcal serogroup, as well as antibodies to serogroup A meningococcal lipopolysaccharide. The above-mentioned heterogeneity of immune response to the injection of meningococcal vaccine is observed in the hyperimmunization of rabbits, in the vaccination of humans in a single injection and can be detected in immune sera by the precipitation test, by counter and two-dimensional electrophoresis and by the passive hemagglutination test with erythrocytes sensitized with group-specific polysaccharides.
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000942:Antigens, Bacterial / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology*; D006801:Humans; D007106:Immune Sera / Q000302:isolation & purification; D007114:Immunization; D009345:Neisseria meningitidis / Q000276:immunology*; D011817:Rabbits; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D007106:Immune Sera
vernacular_title: Serologicheskaia geterogennost' immunogo otveta na vvedenie meningokokkovoĭ polikomponentnoĭ vaktsiny.