Oral and inhaled sodium cromoglycate in challenge test with food allergens or acetylsalicylic acid.
The prophylactic effect of oral and inhaled sodium cromoglycate (SCG) in challenge tests of patients with IgE-mediated food allergy or sensitivity towards acetylsalicylic acid (ASA) was investigated. In food allergic patients SCG administered orally protected against an asthmatic reaction whereas inhaled SCG was without effect. In ASA sensitivity neither oral nor inhaled SCG protected the patients against bronchospasms. SCG seems to act on mucosal surfaces and may inhibit uptake of macromolecular antigens but not affect the absorption of ASA.
D000284:Administration, Oral; D000328:Adult; D000336:Aerosols; D001241:Aspirin / Q000009:adverse effects; D001249:Asthma / Q000188:drug therapy* / Q000209:etiology; D001985:Bronchial Provocation Tests; D004205:Cromolyn Sodium / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005512:Food Hypersensitivity / Q000188:drug therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate
D000336:Aerosols; D004205:Cromolyn Sodium; D001241:Aspirin