Effect of PEEP on lung water content in experimental noncardiogenic pulmonary edema.
After administration of monocrotaline to dogs to produce noncardiogenic pulmonary edema, one-half of the animals (controls) were treated with intermittent positive pressure breathing (IPPV), and one-half with that ventilation plus the addition of 10 cm H2O of positive end-expiratory pressure (PEEP). After 6 h, the animals treated with PEEP demonstrated significantly better arterial oxygenation and reduced AaDO2, but lung water, quantitated either postmortem or in vivo by indicator-dilution techniques, was no less than controls. Although PEEP improves gas exchange, it fails to modify the degree of pulmonary edema represent.
D000818:Animals; D001834:Body Water / Q000032:analysis*; D004285:Dogs; D007384:Intermittent Positive-Pressure Breathing; D008168:Lung / Q000503:physiopathology*; D016686:Monocrotaline; D010100:Oxygen / Q000097:blood / Q000502:physiology; D011175:Positive-Pressure Respiration; D011654:Pulmonary Edema / Q000139:chemically induced / Q000503:physiopathology* / Q000628:therapy; D011763:Pyrrolizidine Alkaloids
D011763:Pyrrolizidine Alkaloids; D016686:Monocrotaline; D010100:Oxygen