[Mathematical description and study of the folic acid cycle reactions].
A general description of the folic acid cycle and associate reactions of thymidilate, purines, methionine and serine biosyntheses is presented as a system of differential equations. The concrete models of this reaction complex as well as methotrexate transport into the leukemia L 1210 and Ehrlich ascite tumour cells and the dynamic inhibition of the target enzyme--dihydrofolate reductase--by methotrexate have been described and investigated. The adequacy of mathematical models to the experimental data has been demonstrated.
D000818:Animals; D001692:Biological Transport; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism; D005492:Folic Acid / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D007939:Leukemia L1210 / Q000378:metabolism; D008433:Mathematics; D008715:Methionine / Q000096:biosynthesis; D008727:Methotrexate / Q000378:metabolism; D051379:Mice; D011687:Purines / Q000096:biosynthesis; D051381:Rats; D012694:Serine / Q000096:biosynthesis; D013762:Tetrahydrofolate Dehydrogenase / Q000378:metabolism; D013938:Thymidine Monophosphate / Q000096:biosynthesis
D011687:Purines; D013938:Thymidine Monophosphate; D012694:Serine; D005492:Folic Acid; D008715:Methionine; D013762:Tetrahydrofolate Dehydrogenase; D008727:Methotrexate
O matematicheskom opisanii i issledovanii zakonomernosteĭ funktsionirovaniia tsikla folievoĭ kisloty.