Comparison of the mutagenic potency of 2-chloroethanol, 2-bromoethanol, 1,2-epoxybutane, epichlorohydrin and glycidaldehyde in Klebsiella pneumoniae, Drosophila melanogaster and L5178Y mouse lymphoma cells.
A series of 2 haloethanols and 3 epoxides was investigated in 3 mutagenicity test systems, namely (1) the fluctuation test in Klebsiella pneumoniae, (2) the sex-linked recessive lethal test in Drosophila melanogaster, and (3) the HGPRT test with L5178Y mouse lymphoma cells. The order of mutagenic potency was, in Klebsiella: glycidaldehyde greater than 2-bromoethanol = epichlorohydrin greater than 1,2-epoxybutane greater than 2-chloroethanol; in Drosophila: glycidaldehyde = epichlorohydrin greater than 1,2-epoxybutane; in mouse lymphoma cells: epichlorohydrin greater than 1,2-epoxybutane. The haloethanols were non-mutagenic in Drosophila. 2-Chloroethanol and glycidaldehyde were negative in mouse lymphoma cells. The high mutagenic potency of epichlorohydrin as compared with 1,2-epoxybutane was consistent in all systems, and with published data.
D000447:Aldehydes / Q000494:pharmacology*; D000818:Animals; D002728:Chlorohydrins / Q000494:pharmacology*; D004331:Drosophila melanogaster / Q000187:drug effects; D004811:Epichlorohydrin / Q000494:pharmacology*; D004852:Epoxy Compounds / Q000494:pharmacology*; D000431:Ethanol / Q000031:analogs & derivatives* / Q000494:pharmacology; D004988:Ethers, Cyclic / Q000494:pharmacology*; D005023:Ethylene Chlorohydrin / Q000494:pharmacology*; D005260:Female; D007711:Klebsiella pneumoniae / Q000187:drug effects; D007940:Leukemia L5178 / Q000235:genetics; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*
D000447:Aldehydes; D002728:Chlorohydrins; D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D009153:Mutagens; D004811:Epichlorohydrin; C027488:1,2-epoxybutane; D000431:Ethanol; D005023:Ethylene Chlorohydrin; C007871:glycinaldehyde; C025475:ethylene bromohydrin