The mutagenic effects of diepoxybutane in wild-type and mutagen-sensitive mutants of Drosophila melanogaster.
Genetic tests reported here demonstrate that among the DEB-induced mutants on 2 X-chromosome loci, viz. y and w, at a minimum, one-third are chromosome deletions. Among 11 MMS-sensitive mutants tested, 9 are also somatically sensitive to DEB. In addition direct genetic tests established that the capacity to repair DEB damage induced in sperm is impaired in females homozygous for 2 mutagen-sensitive mutants. By inference the same is also the case in females homozygous for 3 other mutagen-sensitive mutants.
D000818:Animals; D002872:Chromosome Deletion; D004247:DNA / Q000235:genetics; D004260:DNA Repair; D004331:Drosophila melanogaster / Q000235:genetics*; D004852:Epoxy Compounds / Q000494:pharmacology*; D004988:Ethers, Cyclic / Q000494:pharmacology*; D005260:Female; D008297:Male; D009153:Mutagens; D009154:Mutation / Q000187:drug effects*; D010641:Phenotype; D012730:Sex Chromosomes / Q000187:drug effects*; D014960:X Chromosome / Q000187:drug effects*
D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D009153:Mutagens; C007366:diepoxybutane; D004247:DNA