title: Thromboplastin (factor III) activity in human monocytes induced by immune complexes.
abstract: Immune complexes induced the synthesis of apoprotein III, the protein component of tissue thromboplastin (tissue factor), in human monocytes cultured in vitro. The response was maximal (11.1 +/- 1.7 fold increase (mean +/- SEM) when immune complexes were formed at antigen/antibody equivalence. Immune complexes formed with the antigen-binding fragments (F(ab')2) of immunoglobulins induced a 4.7 +/- 1.4 fold activity increase, suggesting that another signal mechanism in addition to the Fc-receptor may be involved.
mesh_terms: D000818:Animals; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D003165:Complement System Proteins / Q000378:metabolism; D004306:Dose-Response Relationship, Immunologic; D006168:Guinea Pigs; D006801:Humans; D007700:Kinetics; D009000:Monocytes / Q000378:metabolism*; D011817:Rabbits; D011961:Receptors, Fc / Q000378:metabolism; D012709:Serum Albumin / Q000276:immunology; D013925:Thromboplastin / Q000096:biosynthesis*; D014168:Transferrin / Q000276:immunology
chemical_list: D000936:Antigen-Antibody Complex; D011961:Receptors, Fc; D012709:Serum Albumin; D014168:Transferrin; D003165:Complement System Proteins; D013925:Thromboplastin