Dose response of intravenous mannitol on the human eye.
At a dose of 1 gm/kg body weight, intravenous mannitol caused a significant reduction in both intraocular pressure and anterior chamber depth in seven sitting, normal subjects. Intraocular pressure dropped from 15.3+/-4.6 to 11+/-3.4 mm Hg and anterior chamber depth decreased from 3.18+/-.34 to 3.13+/-.34 mm Hg. Intravenous mannitol may lower intraocular pressure without reducing vitreous volume.
D000328:Adult; D000867:Anterior Chamber / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007275:Injections, Intravenous; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008353:Mannitol / Q000008:administration & dosage* / Q000494:pharmacology; D008875:Middle Aged; D014822:Vitreous Body / Q000187:drug effects
D008353:Mannitol