Gastric pepsin secretion after prolonged use of cimetidine.
Eleven patients with proven duodenal ulcer disease but no crater endoscopically were placed on a double-blind, 12-month study of cimetidine vs. placebo b.i.d. There was no evidence of either pepsin or acid rebound hypersecretion at the end of the 12-month study and no obvious differences in this small number of patients between placebo and cimetidine treatment.
D002927:Cimetidine / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000188:drug therapy*; D004384:Duodenoscopy; D005260:Female; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D010434:Pepsin A / Q000378:metabolism*; D010919:Placebos
D006146:Guanidines; D010919:Placebos; D002927:Cimetidine; D010434:Pepsin A