Effect of indomethacin upon angiotensin-induced changes in blood pressure and plasma aldosterone in normal man.
The effect of indomethacin (75 mg/day for 3 days) on the response to i.v. angiotensin II was investigated in eight healthy, sodium-repleted, male subjects. Indomethacin reduced the release of aldosterone during the i.v. administration of angiotensin II (5, 10 and 20 ng kg-1 min-1), whereas the pressor response to angiotensin II and to succinamyl1-val5-phenylglycineacetate8-angiotensin II, an agonistic angiotensin II-analogue, was increased. Plasma renin concentration was reduced following treatment with indomethacin. These data confirm the modulatory influence of endogenous prostaglandins upon the vasoconstrictor effect of angiotensin II and could suggest a direct interference of prostaglandins with the secretion of aldosterone.
D000328:Adult; D000450:Aldosterone / Q000097:blood*; D000804:Angiotensin II / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D004347:Drug Interactions; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D013997:Time Factors
D000804:Angiotensin II; D000450:Aldosterone; D012964:Sodium; D011188:Potassium; D007213:Indomethacin