[Glucose-1-phosphate associated with total parenteral feeding. Study of various metabolic effects and leukocyte functions].
The effects of glucose-1-phosphate (250-500 ml given by i.v. infusion over a period of 3-4 h for 3-5 days) on the quantity of exogenous insulin administered and on leukocyte adhesion and chemotaxis were studied in 4 groups of post-operative patients submitted to TPN (total parenteral nutrition), TPN + glucose-1-phosphate, standard infusion therapy and standard infusion therapy + glucose-1-phosphate respectively. With the use of glucose-1-phosphate the quantity of insulin administered could be significantly reduced (P less than 0.01) thereby an increased utilization of glucose, induced by the phosphorylated saccharide, was confirmed. Moreover, glucose-1-phosphate, through its action on intracellular sugar metabolism, increased leukocyte adhesion during TPN. This phenomenon might have a favourable effect on some of the functions carried out by these cells on the inflammatory response.
D001786:Blood Glucose / Q000378:metabolism*; D002448:Cell Adhesion / Q000187:drug effects*; D002633:Chemotaxis / Q000187:drug effects; D005260:Female; D005958:Glucosephosphates / Q000378:metabolism* / Q000494:pharmacology; D006801:Humans; D007328:Insulin / Q000627:therapeutic use; D007962:Leukocytes / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010289:Parenteral Nutrition, Total
D001786:Blood Glucose; D005958:Glucosephosphates; D007328:Insulin
Il glucosio-1-fosfato in associazione alla nutrizione parenterale totale. Studio di alcuni effetti metabolici e di alcune funzioni leucocitarie.