[Antitumor action of thiophosphamide against a background of glucose modification of the tumor cell mitotic cycle and a decrease in intratumor pH].
The scheme of thiophosphamide injections on the background of glucose infusion intravenously has been employed. It was shown that thiophosphamide injections at the moment of the increased quantity of tumor cells in G2-phase, in the transition G1 leads to S of the cell cycle ad hyperacidity of tumor tissue enhanced significantly the therapeutic effects. The complete tumor regression was noted in 60% of cases.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005947:Glucose / Q000627:therapeutic use*; D006863:Hydrogen-Ion Concentration; D007399:Interphase / Q000187:drug effects; D008938:Mitosis / Q000187:drug effects*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy*; D051381:Rats; D013852:Thiotepa / Q000627:therapeutic use*
D013852:Thiotepa; D005947:Glucose
Protivoopukholevoe deĭstvie tiofosfamida na fone modifikatsii gliukozoĭ mitoticheskogo tsikla opukholevykh kletok i snizheniia vnutriopukholevogo pH.