Thromboplastin (factor III) activity in human monocytes induced by immune complexes.
Immune complexes induced the synthesis of apoprotein III, the protein component of tissue thromboplastin (tissue factor), in human monocytes cultured in vitro. The response was maximal (11.1 +/- 1.7 fold increase (mean +/- SEM) when immune complexes were formed at antigen/antibody equivalence. Immune complexes formed with the antigen-binding fragments (F(ab')2) of immunoglobulins induced a 4.7 +/- 1.4 fold activity increase, suggesting that another signal mechanism in addition to the Fc-receptor may be involved.
D000818:Animals; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D003165:Complement System Proteins / Q000378:metabolism; D004306:Dose-Response Relationship, Immunologic; D006168:Guinea Pigs; D006801:Humans; D007700:Kinetics; D009000:Monocytes / Q000378:metabolism*; D011817:Rabbits; D011961:Receptors, Fc / Q000378:metabolism; D012709:Serum Albumin / Q000276:immunology; D013925:Thromboplastin / Q000096:biosynthesis*; D014168:Transferrin / Q000276:immunology
D000936:Antigen-Antibody Complex; D011961:Receptors, Fc; D012709:Serum Albumin; D014168:Transferrin; D003165:Complement System Proteins; D013925:Thromboplastin