[Inhibition of the growth of 7,12-dimethylbenz(a)anthracene- and N-nitrosomethylurea-induced mammary gland neoplasms by methionine in rats].
The diets supplemented with 0.5% methionine inhibited the development of mammary adenocarcinomas induced in female rats with 7,12-dimethylbenz(a)anthracene and N-nitrosomethylurea by 3.8 and 2.3 times, respectively. Methionine produced no effect on the incidence of other new-growths. It is suggested that the mechanism by which methionine exerts an antineoplastic effect on mammary carcinomas is a consequence of its hypolipidemic and neurotropic activity.
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors*; D000230:Adenocarcinoma / Q000517:prevention & control; D000232:Adenofibroma / Q000517:prevention & control; D000818:Animals; D000970:Antineoplastic Agents; D001551:Benz(a)Anthracenes / Q000037:antagonists & inhibitors*; D005260:Female; D007680:Kidney Neoplasms / Q000517:prevention & control; D007942:Leukemia, Experimental / Q000517:prevention & control; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000517:prevention & control*; D008715:Methionine / Q000627:therapeutic use*; D008770:Methylnitrosourea / Q000037:antagonists & inhibitors*; D009607:Nitrosourea Compounds / Q000037:antagonists & inhibitors*; D051381:Rats; D012626:Sebaceous Gland Neoplasms / Q000517:prevention & control
D000970:Antineoplastic Agents; D001551:Benz(a)Anthracenes; D009607:Nitrosourea Compounds; D015127:9,10-Dimethyl-1,2-benzanthracene; D008770:Methylnitrosourea; D008715:Methionine
Tormozhenie metioninom razvitiia raka molochnoĭ zhelezy, indutsirovannogo 7,12-dimetilbenz(a)antratsenom i N-nitrozometilmochevinoĭ u krys.